<?xml version="1.0" encoding="UTF-8"?>
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<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q436</accession>
    <name>A0A3D8Q436_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Deoxyhypusine synthase</fullName>
            <ecNumber evidence="6">2.5.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_13064</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine</text>
            <dbReference type="Rhea" id="RHEA:33299"/>
            <dbReference type="Rhea" id="RHEA-COMP:10143"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57484"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="EC" id="2.5.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="6"/>
    <dbReference type="EMBL" id="PDLN01000025">
        <property type="protein sequence ID" value="RDW56599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q436"/>
    <dbReference type="OrthoDB" id="294378at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.910.10:FF:000003">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00321">
        <property type="entry name" value="dhys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703:SF0">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00020607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW56599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="359" mass="39044" checksum="EB1D864EB6B0A639" modified="2019-01-16" version="1">MTLESENSAAPPSSVTAAVLVPSNEMPEGSQKVEELDFNAFAGRPITVDDLVSGMNHMGFQASSIGEAIRIINEMRAWRDPETGDGTTIFLGYTSNLISSGLRGTFRYLVEHKHVSAIVSTAGGIEEDFIKCLGDTYMGSFSTPGAGLRAKGLNRIGNLIVPNQNYCAFEDWIVPILDKMLEEQEASKGTENEINWTPSKVIHRLGKEINDERSVYYWAYKNDIPVFCPGLTDGSLGDMLYFHTFKASPLQLKIDIVEDIRKMNTIAVRAKRAGMVILGGGIVKHHIANACLMRNGAESAVYINTAQEFDGSDAGARPDEAVSWGKIKVGADSVKVYVEATACFPLIVAATFAKERPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q5X9</accession>
    <name>A0A3D8Q5X9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dipeptidase</fullName>
            <ecNumber evidence="2">3.4.13.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_12705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q5X9"/>
    <dbReference type="OrthoDB" id="445695at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF12">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017497195" description="Dipeptidase" evidence="2">
        <location>
            <begin position="21"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW57255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="434" mass="47780" checksum="17950D55B98BBF9E" modified="2019-01-16" version="1">MQLLLTSLLALPWFVPSVMGQQEPLGEQDPFYVQALEIMEKSPLIDTHVDLPQIIRSLGRRPLEIIPQLAGNLPGHVDIPRMRKGRLGGAFWTVWAPCHGIGGEDPGEDFNNPTNALRDSLEMLDLIQNMIKQHPDHLEYAHSSTDVQRAFQNGKIASLIGMEGTHLLGNSLGAMRIFAQMGVRYITLTHMCHSAFASANGLGGVENAPPVHPGNGLTDLGRDLIRELNRLGVLIDLSHTSDNTSRQALELSTAPVIWTHAGSRAIWDHQRNIPDDILHMIGDGPGKNKGLVHSIFYPAFLGPSESANVSTVANHIEHIASIVGRKHVGIGSDFDGIPYSVKGLDDVSQYPNLVAEFLARGWNESEVQDLMGGNLLRVMDEVDAVRDQSAHLLPSAEIWDLRKDLPAEWGGANDFFYPVDVRDLKNNVLRHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q662</accession>
    <name>A0A3D8Q662_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NB-ARC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_12763</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q662"/>
    <dbReference type="OrthoDB" id="3522280at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056681">
        <property type="entry name" value="DUF7779"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040586">
        <property type="entry name" value="FxSxx_TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25000">
        <property type="entry name" value="DUF7779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NB-ARC" evidence="2">
        <location>
            <begin position="373"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7779" evidence="3">
        <location>
            <begin position="657"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1208"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW57313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1245" mass="138091" checksum="3D5E9C2E09397883" modified="2019-01-16" version="1">MSNTVVGPQLSILDLIRDPAISYLKTVVQPPTPNIDIVAVHGLNIPFHGKPGKGESFGINTWVAGESDKPGHAKFKKLWLKDFLPDRFPRARVMIFGYNSNVGLNTSTAGVAGAADDLLAKLTHKRRDIEDRPILFAVCKARSNPQYKVLYPHIRSIAFFATPHRGGLHAELGQAAAGGLRRLTGNVRSSVMESLRPDSFTAPEIHRSFRDCLSDNNIRVCSFYEARPMRPLVHLIVDQNSAVLGLEFPREVQYLVPESTHSSICKFESKTENYEVIIDHLADLVDYSLGNNIYESRSLTDSTLSLSRSRASSLNLKYTSDEFEEVRRTSDYFGVELDLHRSSSPFGYRGQKRDTGPWFVLPNIEIPGFVGRESLFETIQAALIHETPSQTRIALHGLGGVGKTQLALKVIEWYRSSFPQESIFWLRASNITVFSQSLEDVAAQCNIVSLERNPRKVLHSVQQHLLDARNGRWLIIADNADNYDSLENPSRFSLQTSSQSTSKFRRIPMATMIPRCAHGRILFTTNSKVIANQLVAPGGEAIEVALMSQQESKLLLQRQLDGTSRSSTSPPSYEQSLPSNEDLENLATHLGNLPLAIAQAAAYMRQQSLTAATYLKLILVSDSSLSDLIDHDFQGYGIEDEFSKAIATTWNAAFDSIERDCPSAYDMLSFMAFLEPQSIPRSLLKELQPDERQLTAISLGTLQAYALISFEPCTGNCSLHRLVQLAIRKRLEVKEAAAKTSTTALRILATCFPDKEERGLNLAKGSELLPHALKVLSSQFTESDVTNIQASTLCSNISHYYTYQGDYNEAIRQSRTADVYLAKVIQPHRRLTLSNQATQVWALREAGKTEETLELAKTVWLGNKKEYGPSADTTIRSHLVLGLLYQDLGRYKECLSIAKHCVKSLQKTNKEHGLPLLHAKSRLGRSHYFLGNYTESENILREVLTHATQELGPEHAETLRIRHRYAFAVLALGRAAECNKLCSENWAVQNAALGEQHPDVLKTLNLKAMALQELGDYEAAVRYHRRIYRKATELAGPDHHHTLKAADCLADALSAWSASENAASSGEILKEAQDLYNQNLQNAKRKAHPDTLRMQSSLANILRLRGRVSEAKTLQSEACDKLQSALGKQHPLTLDASENLARCLKDLGKEKEAVKLAKAVLERREKALGWEHYATVRTAKLVLELEPHGKKNGKLRARVAGVEPEVDARLARAGSTGSGGSGVGRSSLDPSGKLQSAGLYPSSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q809</accession>
    <name>A0A3D8Q809_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ASST-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12601</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q809"/>
    <dbReference type="OrthoDB" id="5427350at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF5">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017537110" description="ASST-domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW57800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="595" mass="66692" checksum="316A621158BCF312" modified="2019-01-16" version="1">MRASAFFLLGLVSAVVADNFPYFQSVEFDQGKFGPYPNRSYVATPQLIAPTLNFLQSSPQCDNGTYTMVCLRGDRIPTTAKSPMILDDKGQLVWMNASYGETFALGVQKYNGSDYLTFWKGNPAVGGHGEGYYYMLDHEYKERYRISAGNGIPGDLHEFRITPEGTALVTLYPAKQATMSWRVRGGKNGFPNRKGWIFDSTVREIDIATDKVIFEWNASDHYEPTESQMPAGMAGARKNDGYDFFHINSIDKDYRGNYLVSARYMHGLTYINGTDGSIIWILGGKRNSFTDLSNGTATSFAYQHDGRWNPEHTGVNIFDNGEHFGTPSAYEGSRAVEILLDEEKMTAQLKRSFVNPRKIRSGSQGNMQVLPNGNVLVGYGLNAAWTEYAADGNVLCDVHIGAESDFNTIAVETYRVNKFPWVGRPTTPPDIAFKDGHVYVSWNGATEVKKWVLQASKGAGRNLKVIQQAEKDGFETAIPVNNTNWCFVKAVALDSKSRKLGVSKLIETGCVLDEVEEQPEDNELPEELPAEEVEIDNDVLDMSYWMNDRILFSLSLWKTLELLGIVGASIGMWELRHSRVLRKMYYVSVRKMWGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q9F3</accession>
    <name>A0A3D8Q9F3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Luciferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_12359</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q9F3"/>
    <dbReference type="OrthoDB" id="5561043at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF30">
        <property type="entry name" value="XENOBIOTIC COMPOUND MONOOXYGENASE, DSZA FAMILY (AFU_ORTHOLOGUE AFUA_6G01920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="2">
        <location>
            <begin position="31"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW58429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="522" mass="57230" checksum="F26BED8FF816E194" modified="2019-01-16" version="1">MAKKLMQLNFFENTSCGNASCQGQWKNPLDKASTKDRAQYYINLAKLAEKGKITCVFFTDSYGSHEVYEKSIAATLAGGGHVGHLDPVVYIAPMALATESVGFAVTATSSYLNPYTMARTWSSLDHVTDGRIGWNVVTSFSDSGAKAMGLDKIIPHDERYEKADEFMDVLYDLWEGSWEDGAQVFDVENEIAYDPKKIRKIEHKGKYYQMSAYHPTHPSPQRTPVIFQAGASKAGMAFAGKHAEALFVAGPTPAAVKKQVQTVREEANKLGRDGSAIKFFHGILPIIGRTVEEAQAKYELAKSLAHSEGGMARFSGFTNLDLSQYPPDEPFEFKGEQSEASIHGVIAMCKEIAGTQEDDGPWTPRKLGNMMALGGTGAVPVGTPEMVADEMERWMAEADIDGFNVMQVTSPTSYEDVVELLVPELQRRGVYWMDYPVPGGSLRENIHGIKGQKLVKEDHPAYPFKWNVRKENGISAWDARQNGLEIAKAAAAAKSAGEPESTAEKVPEVIAIREAAGEEIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q9N1</accession>
    <name>A0A3D8Q9N1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NmrA family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_12439</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q9N1"/>
    <dbReference type="OrthoDB" id="3358371at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF14">
        <property type="entry name" value="SNOAL-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="3"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW58509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="350" mass="38603" checksum="444D8F60FEDD3663" modified="2019-01-16" version="1">MTSKRILVIGGTGAQGFAVVKALLEAEEPYSIRVLSRNPDSELVRRTFKSYPQVEFAKGSFMDFASVEKALDDCYGVYVNTDGFTVNEPDELWAGVRIFEVANTIPTLRHFVYSSIDYYLQLTNFNHKYAAHHTNGKGRVHTYLQGMSSPAHPSSQLAWTVLVTGAYDEDLIGGPLVPHIAADGTRVFRLPLADGHLPLMTLKDCGAFALAIFQDRDAWSGKTLNAVSHFATGHEIADTLSRVSGVRARYESIPTEEWVNTLPYGGVPVASMYPDGITAGQNFSMWWPGFQDSVLLKLGTRDLAELKRIHPDLQSLEDWMVETGWDGSAKPVLKGFIDGGITAESQQLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QB75</accession>
    <name>A0A3D8QB75_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_11945</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QB75"/>
    <dbReference type="OrthoDB" id="3353407at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021822">
        <property type="entry name" value="DUF3405"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205">
        <property type="entry name" value="CHROMOSOME 19, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36205:SF2">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11885">
        <property type="entry name" value="DUF3405"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017569995" evidence="2">
        <location>
            <begin position="25"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="609"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="655"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW59021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="676" mass="76993" checksum="7FD4263F35A6F1BE" modified="2019-01-16" version="1">MLRLRTSIVLATLLIATYISFSRSSIRSNVQLFQGNSGSANLDWALDLGHRKSTGPPEQRPIEEQQPENQYKTYEEEHEALKSKTGAGSIFGNTLNNLVDTDEQLVSSATLRPTGHRFENATLYEFNPYPEYNSDAWKTQNQGKYVECDGPAGRIPDMLVFSGHSKALEDPPMGSNQDLDINSNLCFERKTRLGPYGYVGEEGDTFMKEVKGISTNVNWDKVNWGKLQKQCIEKNAGRYSEAGKLQTPGWDSIFYLRHPSARRQKTKTRPLGADKSKGGARKQQKPKRGTRTALLLRGYTGMVITDDEKQTIRTLVTELSLKSGGEYEVFLLVQQKDDSFKIENNQTAYQEALQKHIPQEFWDISVLWTDSEMQNLYPTIPGEFQNVHRSQWFSVQKFAQDYPHFDFYWNWELDSRYTGHHYDFLEKLARFGTKQPRKGLWERSNRYYIPKVHGAYDTYFRKQVEKIYGRVAVWGAVAVRKITPKGPSPPTWYQSSDDYSWGVGDDADYITVAPIYNPQTSGWIDRDAMTGYEGAAKTPRRATIGTQSRCSRKLLQIMHEENQRGNHVSSEMTPQTVALHHGLKAVYAPIPMWFDVEWDPRSLDKWFNPGKDRDSGGGGDASPFSWGGEGWEDTAVGGSEWEKTHGRTCLPPMLLHPIKDVEKPPPNFVSTSPLPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QBV8</accession>
    <name>A0A3D8QBV8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane protein 14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_12054</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QBV8"/>
    <dbReference type="OrthoDB" id="5620at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1740">
        <property type="entry name" value="Transmembrane protein 14-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005349">
        <property type="entry name" value="TMEM14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044890">
        <property type="entry name" value="TMEM14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668:SF53">
        <property type="entry name" value="TMEM14 PROTEIN HOMOLOG YJR085C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12668">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 14, 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03647">
        <property type="entry name" value="Tmemb_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="30"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW59130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="11348" checksum="65D9EFEC3B4FD065" modified="2019-01-16" version="1">MAHHPSFTLAGLMAVGGTAGYLRTRSTPSLVAGLGLGVSYAYAGYLIKENKDYGTELALGNSAVLLASAVPRVIKTRARAPVPLALGAVGGLATFYYQKKVREFRYGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QBW4</accession>
    <name>A0A3D8QBW4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6590 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_12121</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QBW4"/>
    <dbReference type="OrthoDB" id="3541266at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046497">
        <property type="entry name" value="DUF6590"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20233">
        <property type="entry name" value="DUF6590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6590" evidence="2">
        <location>
            <begin position="63"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW59197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="277" mass="31203" checksum="05F24737F7211F2A" modified="2019-01-16" version="1">MGKTKPEKAAAGGEKKPDPLGRNKANDIQKGKAKAPQAPQAPRPHRGPRVPTLGGKESAHRASTYTEGDIIHAVSIEMNVDQDTAKTLDENRIMVTFQKKPFFLYAKYRRFVILAKWERHCTVLPIYSYDGQGLINKMASLRREHMTVYFTPSDQSGTYQPESATNKTPGSYGCAYATTLKQFNNIKHVQPSYIHVTEPEVFLYSQKSTIFAKMDEKSQEVLQEFFINTFDTIHRFQLRVDATKTEETNETEKMEETQGLEDDGFTFVGPSGKPKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QE61</accession>
    <name>A0A3D8QE61_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease Z</fullName>
            <ecNumber evidence="4">3.1.26.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_11623</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QE61"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07718">
        <property type="entry name" value="RNaseZ_ELAC1_ELAC2-C-term-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047151">
        <property type="entry name" value="RNZ2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027794">
        <property type="entry name" value="tRNase_Z_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553:SF49">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13691">
        <property type="entry name" value="Lactamase_B_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNase Z endonuclease" evidence="13">
        <location>
            <begin position="111"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="12">
        <location>
            <begin position="675"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="279"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW60017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="934" mass="104237" checksum="FCFD0F9AB2898681" modified="2019-01-16" version="1">MHQLVPKIIKSPGSRNPASTLPRILRYSPPVKNTDNRQSILYLQNIQKQIRRLKNSENLSFDRVHPGPKLEFDREDYWIVFDKRRKDNVSSVPPKILPDPSSSIKMRSWASIITTPTADTPGTAILLHFDNKRYLFGNIGEGTQRACIQRKIGLRNVEDLFLTGTTSWDSTGGLLGMILTLADQTSTARESIEKTRQERLAKKGIVEVAQEAKKAFLNIHGAKNLTHLLCTARRFIFRKGMPVNTNEIRPGRDGKQQDWEPTWSDLNIRVWAMAIEPEATASRSRKRSHEEMSDPESEYALSKPREEQEDEEDRNDQMRKSILSSMFNSTWRLDNLTSTKLSAVKLPAAIFIRNGTGKIEKYNGPPWDPILKNVPDVDVLVRNPWPGASIESLPPTTPSKSSISYIIKNHTQRGKFNPKEAARLGVPPGPAFGKLSNGESVTAKDGSIVTPEMVMGTSREGAGFAVIEIPDVSYIAPTLAREEWSAPELMDGFTSIIWILAPGVLEDSRLQKFMQDHPKWKHVVSSSDCCSNYLALESAATAAIRLHLLDSERFPIPKHINDVTLSEAQKVAKFDRARPGKILLLEPNFEVNDSGIVPYLDTTKVVNEASAEVAALAAVARKQVTSPEYQKKLDEQQADIPCRDAEIITLGTGSALPSKYRNVSATLLRVPGYGNYLFDCGENTLGQLKRVFGNELPSILSDLKVLWISHLHADHHLGTAAVVKAWNQATKHESSKKLMVSSDGHMLSWLREYSEVEDFGFERLELAGLGRLNNKFVYELSETQTTSFGLTSIAATSVIHCAGALACVLRFPNGFSVAYSGDCRPSKSFEEIGYGATLLIHEATFDDELQGDAMAKKHSTTSEALEVGKNMNARRIMLTHFSQRYQKIPVMNTDGNKDQIAIVAFDYMRVKLADFAKIEAYRTALLKLYENEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QEF8</accession>
    <name>A0A3D8QEF8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADH:flavin oxidoreductase oxidase family protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_11805</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QEF8"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000138">
        <property type="entry name" value="NADPH dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF91">
        <property type="entry name" value="NADPH DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW60199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="370" mass="40459" checksum="65F724253D837881" modified="2019-01-16" version="1">MSSKLFQPLQIGQCTLKNRVVMAPLTRFRANDTHAPLPMVAEYYAQRASVPGTLLISEATFIAPQAGGYDNAPGIYSQEQIAAWKKVTDAVHAKGSFIYLQLWALGRAADPSALAKDGFKVKSSSDVAFEGGAKPEPLTEAEIQEYIGLYAQAAKNSIAAGFDGVEIHGANGYLIDQFTQDTANKRTDAWGGSIEKRARFGLEVAKAVVEAVGADKTGIRLSPFSSFQGMKMADPVPQFTYFVNELKKLNLAYLHLVESRINGNADTEATEKVDPLIEAWGKTSPVLLAGGFKPDSAKRAVDEEYKDKDIAIVFGRLFISNPDIVFRVQHGIELTPYDRNLFYNKGEAHGYTTWPFSKEFEAAQEVMTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QEL8</accession>
    <name>A0A3D8QEL8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_11859</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QEL8"/>
    <dbReference type="OrthoDB" id="2590011at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.100">
        <property type="entry name" value="YAP1 redox domain. Chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023167">
        <property type="entry name" value="Yap1_redox_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF6">
        <property type="entry name" value="AP-1-LIKE TRANSCRIPTION FACTOR YAP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111430">
        <property type="entry name" value="YAP1 redox domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="5">
        <location>
            <begin position="102"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="92"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW60253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="393" mass="43341" checksum="B8807F4ACB83C1D0" modified="2019-01-16" version="1">MMDMANAEMSEHYYSSPSHTDLSAASSPHRAAMASLSPTEHYTNKSGSGYGSGQSDHDASKSPLSMSLGFLKNLTEKKTTRVDGQPPKRRGPKPDSKPALTRRQELNRQAQRTHRERKELYIKALEQEVLRLKENFSNVTRDKDSLAEENRQLKALLAQHGIPWTGSGGVDELAISGSNGYTSSGSISGSYGPGSAGFTPPPQSQGQFLGPPASNGRSIVQQQVQRGVDYDQAGIDFVLTLERPCMDHMQFLVERASEPEGEPCGHALMATCPPDPYMENHPEIPFGQSLHQSQHHGAVGSGKTWDISKPDLANLLDLSKRLNLDGEITPVMAWGMILGHERFAELRLEDFEKICDDLKGKVRCYGFGAVLEEFEVRDAIESVFFTKQEYLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QF95</accession>
    <name>A0A3D8QF95_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_11926</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QF95"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056599">
        <property type="entry name" value="AAA_lid_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23232">
        <property type="entry name" value="AAA_lid_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="549"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="827"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="827"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="867"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="878"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="921"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="947"/>
            <end position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW60320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="957" mass="109678" checksum="90EDEFAB8749B033" modified="2019-01-16" version="1">MDNVAKAESHNGTDELEHRRRLPEMGQIRFIPEVRKCNFEHFKNRFNAAKEGIYAVDVLESDASLEQEIAEELKLRQILPMQTTNNKGRLPEPTSTRNVRVGQSSTKVITRVRIQSPSLLLVLSRVMEEDWESRPRTFLSPFRPLIAYHAQICQVLSDLEIKLGQQADTPVTAHTPASRGETSDQEDDDEVRSWDDGTAVLAELRSYVEFMSREIIPIYHRFEALDETSDARVRFEDLWCLFRVGETIIRPCGVGADKDIDNLVLGNRYWRVYALRPAWPKYRVAAPDPRRYISADDEMASFGVQCYYIDYTGDEFCAVSATFEIQPYDGERPIKSLKVFPQRFLPNHEAKLTASIEVSKLFLRNIEMRHTSYNWWTLTLDPLGEPTTDSEGNILRRPEYVDSEVIVDFVEAFQACPSWKPVPSVLKPMEQTKSTTIDDFYICWWLDSNRTKLLAETSEILVLEAGVAIWERNRNLSEDKFLTSVRENDRNNTLTTAEYLLDRDLPLLPLRQFAYVLRDRKFAQVAAPRLTPKDGVDHLSLDWIKGKGKALFILLHGVPGVGKTATAEAVAQASGKPLFTITCGDLGLTPIEVEAALQRIFRLANTWSCVLLLDEVDTFFSQRSKGDTNLTKNALVSVFLRVLEYYDGLLFLTTNRPGALDEAFRSRIHLTLYYPPLDYQQTMEIWKLNIDRLRQVEKDRAEAVSHEPLQINEKGILRFAKEKFHQDHNRNRWNGRQIRNAFQIASSLANFDARKDGIQPRLSVEHFKMIHTVTDDFDKYIKEAKGKSDGELAFDRGDRADHWDIDEGKIGNSPYEHTSAMRGQRFAGGVGLGQRGPFGSMINSQSLQPPSPRPFEPRPNLVRPPSITFNHGSQASLRDWKRSPRRGSKEHGSEPVYNEPSDEYISSDRNNEDDMSSGRSEGPKRGREWCDPETRGWRKRMRTTENNQEDDSISSYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QIC7</accession>
    <name>A0A3D8QIC7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">alpha-D-xyloside xylohydrolase</fullName>
            <ecNumber evidence="5">3.2.1.177</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_11437</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>Hydrolysis of terminal, non-reducing alpha-D-xylose residues with release of alpha-D-xylose.</text>
            <dbReference type="EC" id="3.2.1.177"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.177" evidence="5"/>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QIC7"/>
    <dbReference type="OrthoDB" id="1334205at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061634">
        <property type="term" value="F:alpha-D-xyloside xylohydrolase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06593">
        <property type="entry name" value="GH31_xylosidase_YicI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000053">
        <property type="entry name" value="Alpha-xylosidase YicI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1760:FF:000009">
        <property type="entry name" value="Sugar hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050985">
        <property type="entry name" value="Alpha-glycosidase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007940">
        <property type="entry name" value="PRK10658.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053">
        <property type="entry name" value="GLYCOSIDASE FAMILY 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43053:SF4">
        <property type="entry name" value="MYOGENESIS-REGULATING GLYCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="8">
        <location>
            <begin position="57"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="7">
        <location>
            <begin position="283"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="9">
        <location>
            <begin position="618"/>
            <end position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00052064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00066962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW61545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="767" mass="86015" checksum="56064120ECB9159A" modified="2019-01-16" version="1">MRFRDGMWLVAEGVRAEYAEEVYSFTKNEDGKGLSLLCPTRQIRSRGDVLNLSTLSVDIEAVFDGVLSVETTHWQGARRLGPNFELFPDGKPAASNASITSNEKATTISSGSISASISSKAHSFDIRFHATDGSKELTSLLSRSVGLAYTPGPSNPLQTGDMRNMQHYIFTQTTLSVGESVHGLGERFGAFNKVGQTVTLWNADGGTSSDQAYKNIPFWISSRGYGVFIDTPERVELEIGSERSCRVQTSIEGQRLKWYIIHGPSPKEILNKYTILTGKPGKVPSWSYGLWLSTSFTTNYDEATVNSFLEGMQARDIPVEVFHYDCFWMKAFHWCDFVFDAEKFPDPKAQIARLKSAGLVKKVCVWINPYLGQASSVFKYAAEQGFLVKRKNGDIFQWDLWQTGMGLVDFTNPDAVKWYVSCLEGLFDTGVDAIKTDFGERIPTLDIEWFDKSVDPKRMHNYYAFIYNKVVYEALQARYGKDEAVLFARAATTGTQRFPLQWGGDCESTPEAMAESVRGGLSLGLGGFSFWSVDIGGFEGSPPPWIYKRWVAFGLLCSHSRLHGSNSFRVPWTVDNDDKTEQGCSAVLSKWTALKARLMPYIYAQAQESIKLGIPLSLRAMCLEFPEDPTSWFLDRQFMFGDSLLVAPIFEESGTVEFYLPKGKWTNFFTKEVKAGPGWFTEEHKFDTLPLYVRENTVLVLGKQGETRTVYDYTEDVEVCTYQVGELARTTLVDSTGKEMAKLEFGSKADKKSLDALKCKWNVVQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QIT6</accession>
    <name>A0A3D8QIT6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_11523</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QIT6"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001113">
        <property type="entry name" value="RNP domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="51"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="240"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="329"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="140"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW61631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="361" mass="38069" checksum="38F3A0F96459196D" modified="2019-01-16" version="1">MSAIVEKVTDAVNDVTASLGNTSLSDKPADTTAGDKAAHNEAVLASAAEGRRLYIGNLAYATTEGELTAFFNGYLVESTSIPKNPRTDRPVGYAFVDLSTPSEAERAIAELSGKEILERKVSVQLARKPEPAGEKTENGASGGEGSGVEGGRRRASGRGRGRGRGRGGRTGAAARAARGSKGEEGAEAPVTGEGLPLTDTTNTANSTEEKPKTEKKPREPRAPREPRERGPPADGIPSKNKVMVANLPYDLSEEKLKELFAAYEPSSAKIALRPIPRFMVKKLQARNEPRKGRGFGFVTLASEEQQQKAVSEMNGKEIEGREIAVKVAIDSPDKTDEDANAPAAEAATEPTNGTAEATTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLG4</accession>
    <name>A0A3D8QLG4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BP5796_10965</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLG4"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14079">
        <property type="entry name" value="STKc_AMPK_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14334">
        <property type="entry name" value="UBA_SNF1_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000544">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000069">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000236">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032270">
        <property type="entry name" value="AMPK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013896">
        <property type="entry name" value="SNF1_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16579">
        <property type="entry name" value="AdenylateSensor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08587">
        <property type="entry name" value="UBA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="61"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="428"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="504"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="698"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="464"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="519"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="718"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDW62663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="812" mass="89930" checksum="39A627B196255CBE" modified="2019-01-16" version="1">MIPHGAYEDGELEISLAPSANRRASSGKAPEPSNIHDEKNSKRTATQAAPLKKAEQRIGAYHIIKTLGEGSFGKVKLATHRTTNQQVALKIIARKKLISRDMAGRVEREIEYLQLLRHPHIIKLYTVIKTPSEIIMVLEYAGGELFDYIVQNGKMREEEARRFFQQIICAVEYCHRHKIVHRDLKPENLLLDENLNVKIADFGLSNIMTDGNFLRTSCGSPNYAAPEVINGKLYAGPEVDVWSCGVILYVLIVGRLPFDDEHIPSLFAKIAKGSYIVPNYMSSGASALIKKMLAVNPVHRATIDDIRQDPWFMKNLPAYLQPPVEEFIDTGVDPAKAINPKSIAPNAPAAVQHKLHEQVTEKISKTMGYNVKDVQEALAANEPSAIKDAYLIVRENKLMQANPNLADERGQLMFQAPSPPAWNEAILKLDSGSAPPSPLSKTVKDETKLPPPGRSSVADAVSPRSISSIDTNRSQQSRPYVSKIGILPSSLPTYHRDFMEARKAGRSLDEQPSSLSATHAEDREPHPQTEAEKLETARRLNPHSRSQLKLDEASKRPAGMTPVPQKKTKPVKWQFGIRSRNQPLEAIGCIYRALQKLGAEWVTEDSDWEAPQDMADNDRYDLVDSFTHSLTMKIRTDGSFVSNRNGSGASLHHAESLADTRSGDSSIQFQRVDTNNSAYKLPQDPWVLRVRWRKDGMYPPGTIPPGSTHSSSIDLRRPSVTSLSSTGGSVPSQEVSSPPKAAANHNPQPNNGVIMHLDIQLYEMEAGVYLVDFKCAGYETPEGALLEEKDVTSPFPFLDLASKLIIQLAEAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLP3</accession>
    <name>A0A3D8QLP3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_11011</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLP3"/>
    <dbReference type="OrthoDB" id="445341at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032854">
        <property type="entry name" value="ALKBH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057088">
        <property type="entry name" value="GLRG_09195_Thiored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31212:SF5">
        <property type="entry name" value="ISOCHORISMATASE FAMILY PROTEIN FAMILY (AFU_ORTHOLOGUE AFUA_3G14500)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24470">
        <property type="entry name" value="Thiored_Isochorism"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="625"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="406"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="438"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW62709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1028" mass="114331" checksum="FF75781B415A2A01" modified="2019-01-16" version="1">MSFPRRKITVVSTVTDGSHNRPPMFEIAEGDLPFVRTRSALLALDLQIDFIGKDCLLPVSNPANFVENISNLVPRFRTSGDVIWFRSQFEKSRVINCNTNPESESVITDNEVSAEALEQEARQASLAASTISQNNHNAPARSAGAKSLQVDKDYELKPDEDVAELTETFLTIQPGQQPLIGLQQSPTSNLARSIVEKFDSLRDLIFQKSHYSAFKDGKLVQTLRGRFVTEIYICGTLTNISVFATAMDAARHGYSITLIEDCCGYRSKARHDEALRRLTEFTGCDVISSAELVQDLQEREWARAKAQARKAAPRAEASRRPQPRSTSTSLEDVMKRLQLSGASSTGTDNDNPTMPRTSASSTILARSKSRIKMGGLSLLPDEVPRDSKSESMTQSLPDIDGAPKRERVRAKVKTRRRPSNPPKVSQNDLEAKTPQLEKVSKPEHKSQSTDAALLASQVALENMTISDQKEPALEAETAPTATSGSPVTKHDSADTAFKISVKCKKSDTDYDGSAIIVPRECNPPKITPDLGPIAICEGDTTIINKLLDGKTAEGVFENVRDEVLWQRMSHQGGEVPRLVSVQGDIAADGSFPIYRHPSDESPPLSQFTPMVSKIRKQVEEKLGHEVNHVLIQYYRDGTDYISEHSDKTLDVVPKTFIANVSLGAQRTMVFRTKRKAHCTDEAAESTARKTCRAPLPHNSLCKMGLNTNMRWLHGIRQDKRMKGEKGPEELAYDGGRISLTFRKIGTFLDKDQQKIWGQGAIAKTKETSRPVVNGRTPEAENMLLAFGKENQSSDFDWASTYGKGFDVLHLSNDRKLFLSGDFITDTRVKFILAELNLDWVEGSLSPAFSWKDGQNQTDAPEVPAALPIRFVDNDLSRSTVQGDLAILMYLHTAYGPSEPLSQANLARICTRVFSINNLLEKWRAKPFLAKPFRRELLTWDSWTTEGKYIAGDRISIVDYALWPLLDEICREWGNCDGLGNISAYYKRMKRLESLMKALDGRADLGPLADPKLPRSEWDFKKAADPNHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QM29</accession>
    <name>A0A3D8QM29_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_11129</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QM29"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF83">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="424"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="62"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW62827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="553" mass="61663" checksum="E6ECE5CD06C376C1" modified="2019-01-16" version="1">MATTVPDKSAETAHQLETVPATTLDEKLRGNVLDEYAQDGVKNEHDMTPLEAIKSHPMAVFWCLMVSMCVVMEGYDTILIGNFYAYPAFARNYGVYVPTTQNYQITAEWQSALGNSGGIGAFFGALLNGYLVSMFGQKRVLLGALIVLTAFIFMTVFAQNLVVLLVGEIMCGLPWGIFATTAPAYASEVLPLPLRVYLTSYTNMCFIMGQLIAAGVLSAFVDKKTWQWAYRIPFAIQWAWPLVLFPILLFSPESPWHLVRKGRLEEAEKSIRRLQRSSAGLDPKQALALIVHTNNIEQELTAGTSYLDCFRGVERRRTEISCMCFAGQVFVGSLFAYNSTYFFQQIGFDSTQTYRLNVGSTGMALFGTLCNWFILLPRFGRRKIYLIGTATMTTFLFIIGFLQIGANAHGGKPGPLLHAQGAFTMLWTFCFQLSVGQLGWALPAEVGSTRLRQKTVVLARNAYYLASVIARTLEPYFLNPLKWNIKGFTGFVWGSTGLLTFIWAYFRLPETKDRTFDEIDILFAKGVKARHFAETNVNTFDEGEPVVAAAKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQL1</accession>
    <name>A0A3D8QQL1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Amino acid transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_10587</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQL1"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF6">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="239"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="483"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="48"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW64085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="561" mass="62501" checksum="04FD2904458E9A08" modified="2019-01-16" version="1">MDDIKHPGKVEYGSDEKDAVPVYDSGHATEGIIENVDDLKRRLSGRQIQMITIGGSIGTALFVSIGSGLTAGGPGSLLIAFMMYCVWLAAVNNCIAEMCVFMPVSGSFIRMGSKWVDEAFGFMLGWNFFLYEAILIPWEMTALNLVLTFWRDDIPIAAVCAGCIVLYGIINLFAVKWYGESEFWLSSGKLILIFIVFGFTFVTMVGGNPKHDAYGFRYWKTPGAFAEYVTTGNLGRFEGFLAALWEAAFTIVGPEYVAMMSGEASHPRKNLKRAFKTIYWRFGIFFIGGALACGIVIPYNDTTLINVLSGSSAGGGTAASSPYVIAMHNMGIGVLPHITNALLVTSIFSAGNSYVYAASRTLYSLSLDGHAPQFLRKCTKKGVPIYCFCIVMLFPCLSFLAISSSAGQVITWLANLTEAAQIIDYICMCITYIFFYRAMKAQGFDRKDLPYIGWYQPYCAWFGLGTMTFTVIMYGYSTFLPGWWNVGTFFSYYTMCFVCPILYVFWKVLKKTKVVKPEEADLVWERPVIDAYEAENVEKHIPFWDEVKIMMGFKKAAVDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQQ1</accession>
    <name>A0A3D8QQQ1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_10645</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQQ1"/>
    <dbReference type="OrthoDB" id="10256055at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41677:SF1">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41677">
        <property type="entry name" value="YALI0B19030P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW64143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="386" mass="42411" checksum="39C3B418800E6518" modified="2019-01-16" version="1">MAMSDVLAAPGSPSVFHAMNSPRLAPSTKNVQDGLKRSFAKYLAADHAWDADGLENGKLFSPNKHIVYNEPTNVLTMEDIGYTASNGVSPVAVSDPFPLFSEEAIDIMRNEILDPEVIDNYSYTSDIAPKQVRGYAPKHGKFIFEAWKSPAVLSIISKIAGVDLVPVMDYEIGHVNLSVPAPKKFNEDGSEVAPKEDDDAIVGWHRDSYPFVCVLMMSDTTGMIGGETALKTADGVVKKVRGPTKGCAVVLQGRYIDHQALRAYGGQERITMVTSFRPRSPRVRDDTVLNTVRPISNLSDLYGQTVEYQLENAETRIRRMLKTVRDSMKAGATDVAAIKAFLDFEITAMSHLNKEIVPENMVKMGSVAEICEDERLEAAAKRAKLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QR62</accession>
    <name>A0A3D8QR62_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_10486</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW63984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QR62"/>
    <dbReference type="OrthoDB" id="10052040at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000044">
        <property type="entry name" value="alpha-1,2-Mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF103">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSIDASE MNL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="38"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="445"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="746"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="38"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="492"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="507"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="787"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="567"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="684"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="887"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="973"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="641"/>
            <end position="670"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW63984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="985" mass="109047" checksum="EB9F966FDCA76BD7" modified="2019-01-16" version="1">MLRIPIRLRRYRVFLICAAIVIVALVRFSRTDAWEYSSDGRFDSGDHQATKEQIDRQNPPERQKDNLAEKPNSPKDGDGRPSAVTPGAISSNVVVKTTTSDSFPTLPAVQPTPTLDNTVPRVIIPDRKPQAQVGLYEDEPEEQILYPVNPPGRQEHPVFSQVPTTIRWEKQTEHYPVPTGEIIQLPTGKPLAIPRIQHVFNDETPDAKYNREKRQTKVREEFKRAWNGYRKNAWLHDELSPVSGNFRDPFCGWAATLVDTLDTLWIMGLRDEFEEAAKAVDLIDFTTSPRNDIPLFETTIRYLGGLLAAYDVSEGKYQNLLTKAVELADVLMGAFDTPNRMPVLYYHWKPAFASQPHRASTRANLAELGSLSMEFTRLAQITKEAKYYDAVARITDALSEWQDRGTKLGGVFPDNVDASGCNRTSTVTLPISLDANGHEYHYSHPGKPVGFTPDVPGAVPEPVPKKKATQQQDIAVQIIPGEPSKARIAGWDNEKNSQNSKRDLDSSVPSNDTVAPNQSLPSREAPVSQVGFGNRFQQEAEHCEPQGLISSGTGFGSDTFSMGGGQDSTYEYFTKQHLLLGGLEEKYPKMYKKTANAIRKWMLYRPMLPDNRDVLFSGKVTTRGQPTEDLRLSADVTHLTCFIGGMMGMSAKVFGIDADLEIAKKLTDGCVWAYEATKSGIMPEGAKTVACESTVSCPWNQTIYYLAIDPSGDQRDYVLAEYDKAKAQAVIDDAAKVAAAKAVAASQTSNAADSPGDAAAGNNEQGASSPPILSPIQKRQLGPGGSNAASSVSSQDLSKTTPSESKGKLYDEMSKNTETELDAAPVGFENNVPPTKTIPNESELQVPLEDPFRPLSHQEFVEARIKQLDLPAGFVSVDSAKYILRPEAIESVWYMYRITGEQVWADKGWKMFESIINATSTTLGHSAIYDVLATTPQLRDEMESFWLAETLKYFYLLYSPPDLISLDDWVLNTEAHPFKRPKTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QRG1</accession>
    <name>A0A3D8QRG1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter-38</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_10760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QRG1"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF40">
        <property type="entry name" value="TETRACYCLINE-EFFLUX TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="479"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="513"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="543"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW64258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="600" mass="65342" checksum="D897DBF245B170D5" modified="2019-01-16" version="1">MAHNQSREANNLTRERSSSQQSDGSWGARASLLKNAKSDTSLHSENSPLLGESSSAGPELGRSDTVETWPGQLDFEGLPWWNKPSIYWLLPPFFLFALAFGGIIVPKLNLILSLVCRQYLAEKSANDPSFIFAPVNFGGDNPQCRQPEIQALATKFTLYTTIIAGVLSAIMSPKLGAWSDRYGRINFLIVTSAGGFLTEIITILAAKYPDHVDYTWLLLGSVFEGLCGSFTAGMALTHAYASDCTPPPKRAVAFGYFHACLFSGIALGPFIAAFTFKLTNSLLTMFYAALVIHACFVLFIWLFVPESLSRKRQTSAQEAYVAEEAIRDAQNSSWVSTVQQGNVLAPLKILWPTGHGSAHIRANLVLLSMVDTIIFGTAMGAMTVVVYYSGFQFGWGTYETNLFVSAANTARVSSLILILPLLNYLFRTRRRNKQRRESGFAVPEPNSGCDNFELYLIRSAIFFEILGFGGYALSRQGGLFALSGIFASFGGIGSPTLQSALTKHVPHDKVGQLLGATGLLHALARIVCPTIFNLIYAGTVGSFPQAVFVVLTCCFVLAFSVSWFIKPHVYVEESETNPLGGNSAAQQSAEEIIDEEIVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QTM0</accession>
    <name>A0A3D8QTM0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_09865</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QTM0"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="3"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW65173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="416" mass="47830" checksum="0D8EFBEE778621DA" modified="2019-01-16" version="1">MGLSARFSKDPEIRSQGPLYAVEAKKLLKDDLEHICVENIQACILIGNICLGDSDPDAESLYFVLANRMAQILTLGVVNPADDGVTRETKTRVWWTCFIIDTWASGGSNLSRQFKFELKQPRVPMDETVFFHMKQGDPDVSIAEWKPGLWGHMVKLVEIYVQIQDLNKHLVETAEWDEDSIEDAVRDLAVALVAFEQNLEPEIRYSEVNLARHVSKGLGRTFMAFHLGYHHYCTLLFYQYLDHNRPFTINGKAYADRCKLHATIFCDILKASREQKGAEALYNIVGHITVVSSSVLLHTYLFGEAHELPDSRRRLESNLESLVQLRSYWSSVELMIKRLVIFQNNCMRSLSRNTHRFDRWMVKFLSEHALALDEKTDELPNPWLATGLETMAESTRLERSRVTQSIITNMQNLEYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QU19</accession>
    <name>A0A3D8QU19_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter-16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_09873</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QU19"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF193">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G00940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW65181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="522" mass="54881" checksum="6296606AE8860F0E" modified="2019-01-16" version="1">MDDSRGTTSSSSLDDEKTGAVEQSPRLNSLQDSKDINPVEKSTADPDPPQTTEYLSGYPLYTVVSAICLAGFIYSLDVTIIVTATFFVFVVLFEVGSLICGAAPSSTAFIIGRAVAGIGGSGLFVGALTIVASATPAERRPQTMSMVYAISMLGMVTGPIIGGALTQKASWRWCFYINLPAGAVTLLAVAFVRIPDSKSKSESRLSLFEMISRLDPVGFMLFAPTCIMVLLALEWGGTTYPWNSSIIIGLFVGFFATAVTFVIWEYHQGDTAMVPLHILRQRVVYSSCLSMVAQFGSVQAFSYFLPVWFQTILGVSPILSGLYFLATAGPLVAMTIISGILVSKIGNPAIFAIVGNAIAAIGCGLLSTLSPSSSKAAYICFQLLTGFGRGISLQQPVNAIQKSLQPSMISVGSSMVLFAQFFGGAIFLALAETDFTTSLSAALGKFAPGVNAALVFEAGATGVRNVVTSGQLPGVLIAYNQAIMNAFYLAAAAAAFASCAGWGMGITQNMRKKKPESSTGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QV30</accession>
    <name>A0A3D8QV30_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_10233</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QV30"/>
    <dbReference type="OrthoDB" id="3836772at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005199">
        <property type="term" value="F:structural constituent of cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038843">
        <property type="entry name" value="Sed1/Spi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35523">
        <property type="entry name" value="CELL WALL PROTEIN SED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35523:SF1">
        <property type="entry name" value="CELL WALL PROTEIN SED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017557487" evidence="1">
        <location>
            <begin position="18"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW65541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="221" mass="22364" checksum="2CA0A75CA208CCDA" modified="2019-01-16" version="1">MQYSTLVLGLMATAATATPTLFERQMDCNDQANACRTAPEANQAFCSAQYAACLGYNPYVGAAVTGPVAPIYTGSPFNGSSNATVPCYYATEVVTAITTYCPSATIFTYNNGTPATYTATGPGTVTITNCPCTVTTSYTTKPTNIPVGPTTYPPGASSPPTVVYPSTGGASPPPAGTATSVYTPPVVTSTQACPSCTPFPGAANVQKPALGLLALGVLALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QVC1</accession>
    <name>A0A3D8QVC1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Thiamine phosphate synthase/TenI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BP5796_10146</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2-(2-carboxy-4-methylthiazol-5-yl)ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = thiamine phosphate + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:47848"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62890"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + 2 H(+) = thiamine phosphate + CO2 + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:47844"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:62899"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>4-methyl-5-(2-phosphooxyethyl)-thiazole + 4-amino-2-methyl-5-(diphosphooxymethyl)pyrimidine + H(+) = thiamine phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22328"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37575"/>
            <dbReference type="ChEBI" id="CHEBI:57841"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="EC" id="2.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphooxyethyl)-thiazole + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24212"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17957"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58296"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.50"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-methyl-5-(2-phosphoethyl)-thiazole from 5-(2-hydroxyethyl)-4-methylthiazole: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; thiamine diphosphate biosynthesis; thiamine phosphate from 4-amino-2-methyl-5-diphosphomethylpyrimidine and 4-methyl-5-(2-phosphoethyl)-thiazole: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the C-terminal section; belongs to the Thz kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">In the N-terminal section; belongs to the thiamine-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QVC1"/>
    <dbReference type="OrthoDB" id="4994at2759"/>
    <dbReference type="UniPathway" id="UPA00060">
        <property type="reaction ID" value="UER00139"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004417">
        <property type="term" value="F:hydroxyethylthiazole kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004789">
        <property type="term" value="F:thiamine-phosphate diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009229">
        <property type="term" value="P:thiamine diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01170">
        <property type="entry name" value="THZ_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00564">
        <property type="entry name" value="TMP_TenI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000042">
        <property type="entry name" value="Probable thiamine biosynthetic bifunctional enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000104">
        <property type="entry name" value="Thiamine biosynthetic bifunctional enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00228">
        <property type="entry name" value="Thz_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00097">
        <property type="entry name" value="TMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000417">
        <property type="entry name" value="Hyethyz_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036206">
        <property type="entry name" value="ThiamineP_synth_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022998">
        <property type="entry name" value="ThiamineP_synth_TenI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034291">
        <property type="entry name" value="TMP_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006830">
        <property type="entry name" value="PRK09355.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00693">
        <property type="entry name" value="thiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00694">
        <property type="entry name" value="thiM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20857:SF23">
        <property type="entry name" value="THIAMINE BIOSYNTHETIC BIFUNCTIONAL ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20857">
        <property type="entry name" value="THIAMINE-PHOSPHATE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02110">
        <property type="entry name" value="HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02581">
        <property type="entry name" value="TMP-TENI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01099">
        <property type="entry name" value="HYETHTZKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51391">
        <property type="entry name" value="Thiamin phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0784">Thiamine biosynthesis</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thiamine phosphate synthase/TenI" evidence="18">
        <location>
            <begin position="10"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00061283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RDW65454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="526" mass="54933" checksum="35CC286806BFC4FE" modified="2019-01-16" version="1">MAPSNVDYSLYLVTDSTPAILGDKDLVQVVEAALQGGVTIVQYRDKVSDTGALVSTARKLHEVTKRHNVPLLINDRVDVALAVGCEGVHIGQDDLDLKSARELLGKNAIIGVTVASIEEAETACRDGANYLGIGTMFATATKTNTKDIIGTAGTKQILRAIESIGKDVQTVSIGGINASTVQRVLYQASDSKKKLDGVAVVSAIIAAKDPKQAASELLKLVQNPPPFAAASLANNEKAHDVKTLISEVPSVIKSVGQKTPLSHNMTNLVVQNFAANVALAIGASPIMANNGDEGADLAKLGGALVVNMGTTTGEGLSNFLKSLKAYNLEGGPAVFDPVGAGATTIRRAAVKTLMAGGYFDLIKGNEGEIKTVFGQVVQQRGVDSGVSVSSSLEKATLVRDLAMRERNVVLMTGATDFVSDGVRTFAVSNGNELLGRITGSGCVLGTTISAMLAVHREDKLLAAVAGLLHYEIAAEIAAAREDVKGPGTFVPALIDELYNIQKATQEGDLKWLEKAKVEAVALQPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QXQ8</accession>
    <name>A0A3D8QXQ8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mannitol 2-dehydrogenase</fullName>
            <ecNumber evidence="4">1.1.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_09362</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>D-mannitol + NAD(+) = D-fructose + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12084"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16899"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.67"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the mannitol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.67" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QXQ8"/>
    <dbReference type="OrthoDB" id="418169at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050086">
        <property type="term" value="F:mannitol 2-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046029">
        <property type="term" value="F:mannitol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000129">
        <property type="entry name" value="D-mannonate oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000669">
        <property type="entry name" value="Mannitol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050988">
        <property type="entry name" value="Mannitol_DH/Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013118">
        <property type="entry name" value="Mannitol_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013131">
        <property type="entry name" value="Mannitol_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43362:SF1">
        <property type="entry name" value="MANNITOL DEHYDROGENASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43362">
        <property type="entry name" value="MANNITOL DEHYDROGENASE DSF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01232">
        <property type="entry name" value="Mannitol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08125">
        <property type="entry name" value="Mannitol_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00084">
        <property type="entry name" value="MTLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mannitol dehydrogenase N-terminal" evidence="7">
        <location>
            <begin position="40"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Mannitol dehydrogenase C-terminal" evidence="8">
        <location>
            <begin position="302"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW66613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="506" mass="56650" checksum="481A2D3A4DAE6BFF" modified="2019-01-16" version="1">MAPSTAVKLNNQNIALLRKAEQSQNAVKIPSFDRNGVKEGIVHVGVGGFHRAHLAVYVDELMGQYGLRDWAICGVGLQPFDAGMRDALVPQDCLYTVIERAATGSSARVIGSINSFLYALDNPEAVVAKMAHPDTHIVSMTITESGYYYNENTHELELEHPDIVADLASDLAKPRTTFGYLFAALARRHEAGLRPFTVLSCDNMQKNGTITRDMLLTFARHRDPKIADWIEKLGGFPNSMVDRITPRTGEIDKTNLAETFGIQDAWPVVTEPFMQWVVEDRFADGRPPFEKVGVQVVSDVSDVEKFECHKLRLLNASHTAMSYAAFLGGFEYVHQVLENPLFHNYIYNMMHKEVKPLLPAIPGVDIDEYCNTLLERFANPTIMDQITRLTLNGSGKLPQFIMPSIAEQIMQGDRNFRRLTFCVASWFRYLNGVDEQGKPFFIDDPMAEDLKARAIKGGEKPFPLLDVKSLFGDDLRGDKIFVDELTNAMESLHRDGALATLAKYVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QXW9</accession>
    <name>A0A3D8QXW9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_09385</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QXW9"/>
    <dbReference type="OrthoDB" id="4454541at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF20">
        <property type="entry name" value="AAT FAMILY AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="119"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="10">
        <location>
            <begin position="870"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="572"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="620"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="694"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="581"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="644"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="656"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW66636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1254" mass="136942" checksum="7FD19EC071E577F1" modified="2019-01-16" version="1">MSIEEKGKADAQDISDVAIGNCTVDGEDALLAVNNNGLHRDLKPRHLQMIAIGGVIGTGLFLGTASDLQHGGPAGLLIGYCVMASLLYSVMVALGEMVSQFPMAGGQFALAGRFVAPELGFAMGVLYWYNYIIVLPAELSAAAVLISYWTPAGQTDSTCTAGICNSAMWVGLMLIVVWAINFGGTRVFGEMEFWFCSIKVLTIIGLILVGIIITAGGGPNHQTIGFRFWNETGGFVQYDGIPGAKGRFLGFFSVLINAAFAFIGTEITAIAAAETANPRRTVPRAIKSVWIRLVLFYLCSAFLIGMLVSPSDPSLDLSSTAAKSPFVIAIKNAGITVLPSIINAALLTSAWSAGCADLFVSSRTLHGLSARGHAPKFLGRTRKDGLPWICVLICGAFSLLSFMAASQHGKAGTVFGYFSNMTAICGMISWSGILWTSIRWHKGLKAQGIDRSTLPYRAPFQPYLSYYGLSICILVLIFGGFTSFMKKFDVSSFITTYFPIPFFAVLFFGYKFWHRSKIIDYADLDFVTGASSDIPHQIRQNKEFPSRYLAFQNPHERILHTVAAAQTLPLSSQLGMDKRPPPSPPIPGPDVAPSPSRMAQIVVDLQKRLGQHEARIAELEERQTRLPQSTPAQPLSPPSRLEPQDVETGNDDSDNSHSMNNSYSNDPVSQSPGFSMDSIDLGPPIATLRSLGALSKESAPPSDSHLNGLHSRATLNKNSRSTSYDPISRGILSSHDAQKAINIFFDHCHPHAPLLSEKLRQSCLDWRASSPTLFLAICSVGARFWGNDMSRSNSNQGLHPRFFDLTALLDTAVSRLLLQPTPLDVTLDSIRVLLLYAQWMPCSHEDEHRDSLRPPNTHPRYKSRYNDISAWAVLGLAVRYAVILGLDRAAIAPFQENDESISEEDMSRLRVWHNLVTCDCNLMLASGLPASLDPAPAASVARVFGTHSNAQQPADLRVTALVELVVIAHRATRSSSDFSGRHLDTFSLRKANTELDEWERSWVVRLRHTESQHNQLPFTSVRWYRLAFNSASLGPILSSVNRSEPQPLQISLLQSLETSLTAASQMLLSLSSHGAKYVWQLESQDTSSFPEGRFSVEAAALKRLKYAVDSTWISHTFAVTFLVLCYVRGTIDDNLRICGLSTPASSQTCTAPVPPQSTSIITRLVRLALEIFDGVCQSPAFHPARDFQAIVHNASRLILSPENTESHNQHEIDNSAMQSLLDLIDDSGLEWPGNLLDTGADFTTGWGVDGMLGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R2L2</accession>
    <name>A0A3D8R2L2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_08847</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R2L2"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF30">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04702)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="372"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="443"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW68190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="557" mass="61505" checksum="DB154A1CA1BF17A4" modified="2019-01-16" version="1">MANSLTTVVVPGTVHLVDLNEELHTGHLSSNKEIILIPRPSSDPEDPLNWSRQRKHIAVGCAYLHIFGIGIASAVQYSILDNISADTGITLAELNTGTGLMFLFLGWSCLFWQPIALVYGRRGVYVLSCFLCIIPMVWSAYSKTKAEWYAHRILFGLFGSSVESLPEVTVPDLFFAHERGTYMGIYAFLLFGSNFLAPFFAGFINDGVGWRWVMHFGSITLAVTGILLFFFMEDTIYFRSTFEGLDDDPRTSITQHSTVGNGIEVMEKTTSKPQAPVPGKNVSGVLNYSPVSEHTFPPPKTYIQKLALFVKLDGRLTKKQLFTMMYRPLLIFYHFPITTWCGFLYGTNLSWYNVMNGTTSLILGGAPYNFQAKYVGCAYLSPFIGAAVASVWSGQIADKLTLRLARKNGGVREPEQRLWSMLLPAIIGPAGLILWGVGADHGIHFMGLIIGLGMLVFGLICASSISLSYDVDCFKDLAGETMIAVIIFRNTLGFGFSYAITPWINAQGLTKTFVAVGMISLVCTSSFLAMIKFGKALRRFSTTKYWEYVATSAVAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R2W8</accession>
    <name>A0A3D8R2W8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Transport protein USO1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_09050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5423371at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044986">
        <property type="entry name" value="KIF15/KIN-12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37739:SF16">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37739">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIN-12D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5" id="KW-0505">Motor protein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="316"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1832"/>
            <end position="1923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1935"/>
            <end position="2028"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1042"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1230"/>
            <end position="1294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1747"/>
            <end position="1816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="88"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="122"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="536"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1835"/>
            <end position="1854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1855"/>
            <end position="1896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="1939"/>
            <end position="1952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1960"/>
            <end position="1973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1980"/>
            <end position="2006"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW68393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2028" mass="224375" checksum="FF3017901DFD08E1" modified="2019-01-16" version="1">MSSIERSDSRDSERQLKHQYSTSSDYGKAIVPMWDSSDPERAPPPLPMNPSSPVVTSRPNTSSAIQSAHAALTEKARENSYTSNALTKRLEPSPDRAAMKSATHKRMQSLQGGTVRDLSNMIEGSNALTSPTKSPEKMARRPSTPHANKDFVLEKAPEKEERSTTPTSNRDVPKLRPSLRKPERHQSILGENTPPQSATMLALQNMACKDIDSPLLNITNGSTALVRTPQTFDAISNQILSLTSIATSLQREMSNLTRRSKDNATDLVSLKEATNARDEDIRKSLRELVININEGNHRPSNNYLPSTTGGLYLDNKPHNGSPGSRSVKQFTLPRFPSPNSFESSLDRESMSTPDSTASIALLEKILRDMGTREGQDLLVSRLTEVANRLAEDGMSTAKKLEDLVLFIKENTESQALVAHNLGGDGMGRSRGFSFDEPPRLELDFDKPKSGLMTQRVEALLGSNANKENRRDSVAARNTDVLNDDVLNIIRTVKDSVAQGGGLTAEVKALVRELRGEVLGMGRELGRKLEQSSNKSMAKDSKAEKERVTRVVEDGLEDLKQHMDSVLREHRRQSASSLAKSNAVDYQEIYNAVRAAVNEKTQASRQPSLAKEDVIEAVKEAWENYKPDIELQHFGLEREELLATLKEGMQEYAPQDTSRDIGGATREEVFEAVVEGLKHFSPPRIEAEASLSRDEILDAVRECLEEFEFPAAPAPPPREDDITKDVQDAVRSCLEEFEFPAAPMQDEVTTRLIVLDAVKEGLHEFPAPQDEAITRGVVLDAVKEGLNEFELPPQDEATTRGIVLDAVKESLHDFEFPQPQGEATTRVIVLDAIKEGLQEFDFAAVNSTAVVPRDIGSSLTREDLFDAVKAGLEDAPAGMSPYGEQQVLGRLQDIIELLRNEFQAVSEEAKQNVAAHGRDTEQLLDATKDGFDRLRGDIETYVDRAAGVDIKDDILEDMHESFSTLRAELETLLSKDSSSSLEAVQGELEHLRETMATSLVRGGGSDKDEILDALREGLDDLRANMDRPRDSNESVLSGTGEILDALHDGLENLRAEVEKLASKPVEPVDMTVNYEILDTLKAGLESVRAEIDSLKENAHNDRAVAAITDGAVVAANVASAPDSLKRNDIENLEVLITQLRIKVEALESMPPPFTPPPQAVPGTVLKEDLAVVEEMIRNVHESVNGINNTERSVDEDGIKREDVEAIETLLRNTKAKIDDMDPEQLVKRDHLDIVEALVRETQDNINEFANNMEDVSKKEDVNIVESLVRDVINGLAEMKERAIKESEDLEKVTKTDVEAVEAVCLDVKTAIEQMVLSDIAGLAAKEDVKNLGEMVKEFKDRIETHADSNAKAFEERQAETVGVGERVSEIRIFLDEFRDAMKEQLDAGYTSVEDVAKFLESLGETINKNATVTDDLKDISELMKDEFEKSNAGVVGAKLESDEKFQQTWDKLDNKFDEKFNELISKYDDAQITADARAKEGEEKNADTQEALLGTKAVAEELRSLIDTLGTTLTESVEKMDEAGKTVFNRVDETFTRVEETHADAKAEHQLTREQVFKAIGAIEGVQDKVVEYHPQMLDSIKEILLIVGQHYEHSKTASTNLETKIAEIPPPPAPIEMPLLPPVEKYDDGQVHEKLDRMVEDGGQVHEKLNKIVDHDAQVHEKLEKLADQDGQVQEKLEKLVEHMNDAGKSFAQLDMLDKIHQQVMQTAAEVSDFVSAQTQRIANDHEDKERAVEEASIALEKRLAQKEHVEATVVGLREEEERLRESISILKAEQEDLAHQKMRLSADVSSLETALHIRREELHAMESRAEGLERRILEGVIDHSRALLMSKSTKGKDMMSRKRVSTDSPDRTNSRASNTTHSAVNMAMNGNRSQARPSSTSRRILSLSQITNNVPTGGFKRSHSVKTPSGALRKSSWGGSISQKYGELNKENLALKESEEDQESEEPEDDAETMRRSSHGTTILTGTGVTDSTIDESTEWTGSEVTGSEITGSEMTGSEMTGSDYDSSEAPTEVGGHIVLYDEGEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R3E6</accession>
    <name>A0A3D8R3E6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3'-5' exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_09088</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R3E6"/>
    <dbReference type="OrthoDB" id="1920326at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06141">
        <property type="entry name" value="WRN_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000100">
        <property type="entry name" value="3'-5' exonuclease/helicase (Wrn), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051132">
        <property type="entry name" value="3-5_Exonuclease_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620">
        <property type="entry name" value="3-5 EXONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13620:SF104">
        <property type="entry name" value="EXONUCLEASE 3'-5' DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3'-5' exonuclease" evidence="4">
        <location>
            <begin position="211"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="130"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="425"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="463"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="595"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="96"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="469"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00474"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW68431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="616" mass="68873" checksum="A84A0A1F1387469C" modified="2019-01-16" version="1">MTSFGGSSALAWDALRSTLEALRLRRPLSTDARLQTATPRERLWNPKHGIVFLQNPVSAPRTLSTAATSDVEQEALLHSLAGDVYDLAKTSETCASEGTVKGSTTATEEGVPQDNHATENKSFEVLAGGGVSQQHSEPSIETRSEARSQVVSELPSPEDDAQREVPLSDLRFKISEDRFRKAKDAEYGTSDSYWSYAHYRGPEGEQQKVTVHYCRTKHTTERCLRYFADQKLIGFDIEWKPEASRAQGPKKSVSLIQIASEERIALFHIALFAKDEVDDLVAPTLKKIMEDPAITKVGVAIKADCTRLRKFLNIEAQGIFELSHLYKLIKYSESKRYNLINKRLVSLAQQVQEHLHLPMFKGEVRSSDWSQVLAMDQIVYAASDSYAGLQLYSTMNLKRLALDPTPPLPHHAERNLPIQLADGVTLDTDTNPDELEPEDATTPSARLSSKYLATAVETLELDPDFDINTPSTPTTRKAKPSTSSSKTARSPIVLAATALAEEYRSTHPKCRAQPSSLRAYYIWHEHAHLSIDEIAALLREVPLQRSTVINYVLDTIKLEKLPFHTQRLREVLNFIPKDVAVSRYKTLMKALQAREKAEETAEVNRDLEARPGEGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7F2</accession>
    <name>A0A3D8R7F2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SGNH hydrolase-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_08366</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDSL' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW69969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7F2"/>
    <dbReference type="OrthoDB" id="2141316at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037459">
        <property type="entry name" value="RhgT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G17250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43695:SF1">
        <property type="entry name" value="RHAMNOGALACTURONAN ACETYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017785081" evidence="3">
        <location>
            <begin position="19"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW69969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="328" mass="32611" checksum="6C9E1DC6561C117A" modified="2019-01-16" version="1">MKSFFSLSLAALAAVAAAVPVEHGPGRVGPHGGPGSSKYSSSAVAASTTAAAATSSAVVAASSSVAVSSVAVSSVAVSSATAVAAVASSSSTPTVYLAGDSTMAKGGGGTGTEGWGVFLPYSLTGVKVVNDAKAGTSARSYTNESRFQDIADVVTSGDWVIIEFGHNDGGSLSTTDNLRTDCYGAGSETCTSVNGDIVQTYPTYITAAAKLMTAKGAQVIISPPTPDNPCETGTCSYTAPRFTAYANSSAAAVGSMATFIDHGQHVANAFEALGPTTVDAFYPNDHTHPSPTGSTIVAAQFVLALLCSKNPLAAHVVNTTSSITGSCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8A4</accession>
    <name>A0A3D8R8A4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Core Histone H2A/H2B/H3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_08603</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NFYC/HAP5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8A4"/>
    <dbReference type="OrthoDB" id="1272441at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22908">
        <property type="entry name" value="HFD_NFYC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000017">
        <property type="entry name" value="Ccaat-binding factor complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF8">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="9">
        <location>
            <begin position="83"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="171"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="274"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="177"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="274"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW70206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="316" mass="34635" checksum="3F84ABBFB49EE49E" modified="2019-01-16" version="1">MDSQNPPSSSHGQQQQRQVPAYDTNHGGHYGASAALSAQGYAPVAEFYTGAWANVNQGLHGTYKDILTTYWQQIINHLESDTHDYKLHQLPLARIKKVMKADPEVKMISAEAPILFAKGCDIFITELTMRAWIHAEENKRRTLQRSDIASALAKSDMFDFLIDIVPREEAASHAKRATGPGAPAAQPAAGSTQIPAQHPTMPQQAGHTAQQHAMPPPDYSLGHSLAPEDYRQQPNMYSAQVQPGPGPAYGAPPQQMYGEIEGMYGYPPMQAQQQMYHVPQRTQDPSVGQDAGHNYPRHDGGEGDADAEGERDYEVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8K6</accession>
    <name>A0A3D8R8K6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08784</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8K6"/>
    <dbReference type="OrthoDB" id="10351339at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW70387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="218" mass="24614" checksum="7FAF2386ADD5AE96" modified="2019-01-16" version="1">MQFSIARDLQKTKQRDEMQTLPETTTTSLFGSSKSSQNDIFARQSPAPTIDSSLQPLPNPGQFFPAPPSKDAQSGKHDPLSQLKRKYAIIFLSKLKSIQHLHHVLLETPDDGTTTLKDPQEAILESPWFSAALERESETLETFEYYLRHPRCCLFHASIPSLVPAGYGAGCCVGYVQELRSEMLCEMEDIHKGIMEQLEDVLEKLRIFGKITFDGQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCK6</accession>
    <name>A0A3D8RCK6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">UbiA prenyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_07744</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RCK6"/>
    <dbReference type="OrthoDB" id="434972at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13965">
        <property type="entry name" value="PT_UbiA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050475">
        <property type="entry name" value="Prenyltransferase_related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000537">
        <property type="entry name" value="UbiA_prenyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42723:SF1">
        <property type="entry name" value="CHLOROPHYLL SYNTHASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01040">
        <property type="entry name" value="UbiA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="244"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW71710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="317" mass="35348" checksum="3D4A47D4260E246E" modified="2019-01-16" version="1">MEKIYIEESTLAKESLRSSILYHMKTAYIVTKSDIKTTVLPATTFALVNTISGPLLTTAPTPSPIDILLRLPKAILWAWMNLWLFNLANQRLPDSILEDSINKPWRAIPSGRLTATQARHLLLISIPIVLAASWLLGGRDECIAIMVLTWIYNDLGAGDENFLVRHFLNALGFAAFGAGATQVACGFPNYTLNSTAYQWLGIVVLAITCTIQFQDMEDQPGDRLRGRKTLPIIFGEERTRWWNAFSILGISLVACLFWQVASIGCLVPCALSMVIAGRTLMLHGVGPDRQTFKLWCLWLITLYLLPLAKCHEMSPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RD50</accession>
    <name>A0A3D8RD50_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH La-type RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_08013</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RD50"/>
    <dbReference type="OrthoDB" id="340227at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048255">
        <property type="term" value="P:mRNA stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07323">
        <property type="entry name" value="LAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006607">
        <property type="entry name" value="DM15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792:SF132">
        <property type="entry name" value="LA-RELATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21071">
        <property type="entry name" value="LARP1_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00684">
        <property type="entry name" value="DM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="4">
        <location>
            <begin position="682"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="217"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="851"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="890"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="54"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="77"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="94"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="442"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="452"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="506"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="530"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="553"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="859"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="903"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW71979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1124" mass="121633" checksum="F42D7BC3CDAF6BA5" modified="2019-01-16" version="1">MAANTSASSATATPNPPTFSYAQAAKGRTTATVNSVINSSPGISGVNTPVREATSASNTPSTSVNGAPGSDAGDRSVNGSFNSSGKSDALVSSGLESTSKSTTLVDSNSTPSSPSFGTASTSALPKDDEITLANTSQSGTAWRGERRSQPTGGDKASEYHEPKKGRNSKGGRKKEKAEAAEKEKAEATEKEVAKPEIPLIAAPLPTVNPWMVRMQTQVPKAKVASQDISDNASAHDVSHPVKSDEKKRGKGSVVDSTEKSDGVTINGTVKEPVTASKGVKKGLEGRDDLSVKRVAPRGSRVSEKDEKSILSQLPPPVEDAISWPTPETALEEEKRKAKVYIQEKSEKEEKEDTTTNKPRQKKEWVPVPYTPSVTFNTPIPQRGGRGRGGGRGGREVTGRGNHGPNGSINGEKALASSTVLPGSTDVRDSGKENASAGRASSLPPNSNSNKRTSIDDSQLTRDTRKSAAASEKNKSGVSSAKVDSGNTTDIRTLTSNQTSSTFENGHAARNEKPAADHVASAEASSNPRVGGERKSEPNIRATDHGANFSRDNQQSRDRGEGRVDRGRGGYRGRGGYNNIPNGQQHPHAFTNGHGPAQPNGFPVRPNGPYSPPPQQQPFGNQYGQPSARGRGGVRSQSIPNNAMYGGRFANGNGTQMPPLQTASGIFDYQSMPPMSAMPYNPYVDQFSVVNMVTMQLEYYFSIDNLCKDVFLRKHMDSQGFVFLAFIAGFKRITALSQDIDVLRYACQESEVIEIVKGEDGVDRIRRREGWEQWVLPLAERDESARSEGPQNFVRLGRSQHMMMPGAHSMPLPAFSPNGGDVGFSQYKAGLVTGVQLNGNGHFQSETPLSAAVPDFAPSFPSSNGSSDPLDSETIFTDEEVHKLILVACSPSKGSEKSESSKPFHNTSSRTFSNGSIDEKTLEDLNQDQGLSNGVHATENSPSSTRRSRSPNGSVSSFESHTVMWKKGLKAQVPVAEDANEEPYELVRGRALANRAMAPAVIGETQKDMKLLYDFWAHFLCRNFNAQMYREFRQYAIEDATQRKAMNGVNNLISYYDETLKSRKKVIPETLARHYVELVLNEDLDFEHRGLVKLRAAWRNGALDMKSRKRIDNLLDAKLREELER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RI18</accession>
    <name>A0A3D8RI18_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_07134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RI18"/>
    <dbReference type="OrthoDB" id="10371161at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW73692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="308" mass="34134" checksum="1FE9A16F3141BD13" modified="2019-01-16" version="1">MSKEHLIYGSSAFCSSSTDLTSCSTSTPSSASSSSSSSSSSSFASDQFHRAGPANHSATRSENMDSHPDTCPVRVPNSESTASSLSITSYSSYLLIHDAATGPYVTTTKCPGSDWHIAESKYPSLVRMGGKESRLETIEEETDEEMGIFERLSRTSESDLDPDSDSDPDSDSEYVPDPDDKYEFAAVADLPQWDLRLLEPSTAIGNSHHQERFVGRHPIHTDEARFSAIDAVVDSNPAYLENVARNFTHVVGVVYQEEKERHTRMTSWDVETALLKGIGRARNAQLERDYEKREEYRTSCKLWDMDCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RI53</accession>
    <name>A0A3D8RI53_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_07165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RI53"/>
    <dbReference type="OrthoDB" id="10401478at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="322"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="516"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="379"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="517"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW73723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="540" mass="61260" checksum="DF26A21882C9F6A0" modified="2019-01-16" version="1">MEQSRNTQLRQMMRDPQEGQPGDSTKTAEPEDQLQGLQAENPQVLTQEYLEEPKSMREERDETPASLEVACRSLSQDPQHDNHIAERDESRDQTKEITAEHDKDASKCNESMEESDLLSRENHLYIEDTAHLRSELDQARQMHDRESPYSWMARYEVLVREYEKIRQRDRGLSNNMGMFLQRLDDIEVRLAGIVQNPSALEELLGRASQAGDHDASPSTSEAYRLASEDFGPALTSMQRILPIKLNRISKILGLDEQYGTLDVGDDDANLDTVNGPPLPNTPAPVPSLPKAGLLAPGSQGPLATLPAFEGPKTTLLYASDEADEEPPQIMEQLESPPPPSPREDPPRPETCNEKCVRFEAQLDRVLRQRNYLYTQLIHLIDVENLAADLETRMMQLEANDAYRQQLIDEYEEDLDNVTRDLIVARQTTGVLEQERNNLRSQLHQVTGDHGDSQQDPTQTQTEATGAFYDSEHVRDGWFYAERSRHELELLEGQVQELMVDNENMTDEIERLQNALDAYKRGDGQKTDDNQGDHDEDGGCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIA1</accession>
    <name>A0A3D8RIA1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_07100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIA1"/>
    <dbReference type="OrthoDB" id="10057496at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW73658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="204" mass="23154" checksum="01CF0BEF455EFE47" modified="2019-01-16" version="1">MAYRGWNSRSGFDLGSPPPGTPGFYQTVTHPQYHGWPSYYGATASYGWGQYPQQWQWPNMNPPSGGSIPGMNFHNDLGGVGIPYGYSYIFPEEHCKVHVLKTPTPPWERTINTQDPTSHEKCMVPINVTVQELMQQLGCNNKDPKKNKLYEVTRASNGAWKKGLVMSGDDKTRMKTKITDWGWDKTRTGKPGERSVVWLWLTKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIB8</accession>
    <name>A0A3D8RIB8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_07033</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIB8"/>
    <dbReference type="OrthoDB" id="5130013at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF39">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW73591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="49757" checksum="4D24CDE3B088D4A7" modified="2019-01-16" version="1">MWIYTERYQQIYKFKKTQYIGTYVLPSTLSLSIYPRLEGSETELIPYFFSVVLPSLPAFGIDFENLRGVIIRLAMSDDSAPSQAVRNSLLALAALYMLGSMQKASRFIAAALNSLRASAQKGIGLQQGMQHIIAGMLLCSFEVSSHTLTEVIARSLIVKKIHTFSQSSSIWLVYLSGTKAVMNRFHQHGSYANGDQSLLFQWVFYYDTLARLGIKHWRGYRSLQTQLAKDLGFGKGDSMFTDDEITRFGRSSHRALEILSELCTGVLSPDDPRYRSTVYISWLDQIENQLASIRQELEHNVSLPDIGYQSESVAVKELFVLAALLYMERKAKQLVGTSSKTDKWIEDAFLILSKIDHCNKPFPLFIFGFDARTDLRRRVILEVIDRTIKKANARGLVSLRFLLLRLWIQDDLNAEGNLDLESNSCFFLSKCNFVPCLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RII6</accession>
    <name>A0A3D8RII6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_07208</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RII6"/>
    <dbReference type="OrthoDB" id="4314040at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF13">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="77"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW73766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="624" mass="69109" checksum="07E8F655CA4AEC26" modified="2019-01-16" version="1">MVYCGKPSRGCQMCRTRRIKCDETKPTCLQCQKSRRQCPGYKDDFDLVFRNETQATERRARKSNNAKKINTQLVQRKDAAQRSFSISSNSSEDANDDRSLITPTSATSTGSTSATYAALQGDLQVPVEQQALCYFLANFVYLPQHSNSKGFFDFLLPMMKAEQPDSQLSTAIQAVAMASLANRPNSRGSPLMVQAVAHYAKALKATNIALQSPAQQKSDQTLASILLLGFFETITLEQTNVLAWGAHIDGAVQLVRMRGKKQLRTRVGSALFLVVRTQMIICCLTASKPPVLGTEWWIADAIKDENAQFVAKLCLRVAEMRAELNTTLATSPRTPENFEKVLALMRRAQEMEHDYLAWEEQVPDLWRVKTVAWVDNVPDGDFAKADVCPGKVDMYDDIFVASCWNLARVSRLFISGIVIRCAAWVCAPVDYRTTPEYATAARLGVDMICDIVASIPYHLGWRTDENGALTAGDLTGFACGADNITNPKALGGFFVLYPLFSASCSDFATDSQRKWMKGRLSYISDTMGMNQARTLGSFELRLPSMIIKRDSMGHAVPTIKSYLAARGMDPSSGSTPGNPVQASMQERDAIMRDAWEKNRKELLMKASNAQGESSERILANYLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIP8</accession>
    <name>A0A3D8RIP8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_07163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIP8"/>
    <dbReference type="OrthoDB" id="311506at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW73721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="331" mass="33999" checksum="A6890C1BEA40B1AE" modified="2019-01-16" version="1">MIVGAVLEVVEFKNTVGAELEVSGTDVLGAVVGALVVELLNGVTVLLGILVVVFKNGVEVGTSVLEVLSSTALEVVVFRNGVEVGTDVVFKNGVEVGTDVVFKKGVEVGTVVVFKNGVDVGTSVLEVLSSTALEVVVFKKGVDVGTDVVFKNGVVVGTDVVFKNGVEMGVEVLSNTALEVVVFKNGVDVGTVVVLKNPYVIDMDVVFVGTAVEFKNGVVVGMAVIFVGTVVEFKNGVDVGTAVVFENGVVIVVLSVTLVVEFKNGADVGTAVVFKNGVVLEVLSVALVVEFKKGVGVGVKRLDVGEVVLAKGPVGDIDDDGPPELVVEAAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIV6</accession>
    <name>A0A3D8RIV6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ML-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_07421</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIV6"/>
    <dbReference type="OrthoDB" id="5312224at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF6">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="414"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="492"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="570"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="602"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="633"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="9">
        <location>
            <begin position="90"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="805"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="946"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="868"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1030"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1091"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1165"/>
            <end position="1178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW73979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1189" mass="129458" checksum="AEF3D17E2CE349CB" modified="2019-01-16" version="1">MAKHLTAAHQPRHDRRATLSSTMMTGEPGSADRMAYPRRNFEEPVDSAVTRNEGKLGRTKGRFARWLPGRQVETMGYVLVLIATLWIHPTSAVLIEFQNCLSQSWQHNTPYLLQFDPKYVDAVFNTTDPSHNLKVTVWGNVTGSLPLVNLPSSNDTEYWQNANETAGKIADIPDPSGANKYTTLYNKVNVLTYEPWSQTLDWCNQLQNATCPLAPSFNANASDPYSLPSFSMTNNFYSSYAFTSLTATLIIKNGDTAASVIGCISGNITPDLGSTLSSVIKYIPAVILIIVGIATAFAGVFSPWGSTDTFRWTTNYGRDADLLRLVTPGFGDCLQYIQFVALTGGLTLNYPGFYQPIVSKVSWSALMFNESFVHNKTGTVSLVDGIYVTTGEFGLDNLRQLVGLGNVDDVWTGMVIWLLVILAAVLAFIQIGFAGRWFYRQLMNTQEEDLRAKNMPFSVGNMIRIVFNYFLLPIVALSMFQLVEAGKSPTFTVALAVVMVVLIVGFAVWLLYLIATTRPRSFLFDDLPTVLLYGSLYNTYSDNAAPFALVPVLLTFVRGIAIGAVQPSGIAQLVLLAICEVITILTLHAFRPFHSATSNNLYHTLFAAARFTSVLLMIAFAPSLGVTDGPKGWIGYAILLLHALVLIFLFLLNAIQTIVEVAARMAGAGGDDVGAATRGGLGRVFGMRQLSRRLPRRDAGSRASQLSNAAMLDADRNEYATNANRMRAESAGSNAILLNRQSTGFDSLNVDAVGAAQHPGSSTYTPTTPGEVSTFSFFPSTAAPAGQNRIRGSILGLAAAEASDPYYRPPRFRRPTVESYSPGGRRRGSWASGDWVRRDSEPMDNVEQPEGPSISGRVTPVPQAAVDSEPHEARRSQADYATREVDFYYGVRGPALNANIPSRRIKTGPADPTGIPASAAGWFNKLFKGKTKEKGKGFEVVRSSRMPPNMARNAPGVETPPEGIPVAMGGIRHGPIDSDDEDDVQARSHAKQSPSKRPDTADDDGNLVSPLQSDDEDDGKREVSAFTKVSDLPPSLPGLEPSEDIELPSRYSSKTSSKHQQRIPQFSDVPLVPSVPRKSSRRKSLSVDLTAGQSQHKANSSLDSRLPFERSGSKKRHSAVSSASSMGPVDGQDHSRRASSVLGSFPKHTENDRPTSMGYVHQHNIRTVNPSENPNYIGSSAEVVNERLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJ84</accession>
    <name>A0A3D8RJ84_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alcohol dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="9">1.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_07551</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15938"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:15939"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.2" evidence="9"/>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJ84"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000158">
        <property type="entry name" value="Zinc-binding alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="18"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW74109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="360" mass="38873" checksum="004B6B8667530B45" modified="2019-01-16" version="1">MAETDYTFEGWMGLDNNAANGKMVWQEFEPKTWEETDIDIKITHCGICGSDLHVMRAGWFPTPYPCCVGHEIVGIALQVGLEVTGDIKVGDRVGVGAQADACLQRNGKKCDECGEGKEQYCVDRFVNTYGDFHFNGSKSYGGYALYNRTPSHFVVKIPDGIESSFAAPMLCAGITTYSPLKHHACGPGKKVGVVGLGGLGHFAVLWAKALGADKVVAISRKKSKEADALKLGADVYIATDEDSDWVQHHGRSLDLIISTVSSSKMPMGDYLSLLRTDGTLIQVGNPEDGVLSISAPSLILRRVKLGGSCIGGPNEIREMLQLAAEKKVTPWVQEVPMKDANQAVLGMAAGKAQYRYVLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJB6</accession>
    <name>A0A3D8RJB6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Molybdopterin synthase sulfur carrier subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Common component for nitrate reductase and xanthine dehydrogenase protein G</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Molybdenum cofactor synthesis protein 2 small subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Molybdenum cofactor synthesis protein 2A</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Sulfur carrier protein MOCS2A</fullName>
            <shortName evidence="5">MOCS2A</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">cnxG</name>
        <name evidence="6" type="ORF">BP5796_07426</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by UBA4. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin.</text>
    </comment>
    <comment type="pathway">
        <text evidence="5">Cofactor biosynthesis; molybdopterin biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="5">C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of UBA4, then thiocarboxylated (-COSH) via the rhodanese domain of UBA4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MoaD family. MOCS2A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJB6"/>
    <dbReference type="OrthoDB" id="5595860at2759"/>
    <dbReference type="UniPathway" id="UPA00344"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990133">
        <property type="term" value="C:molybdopterin adenylyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990140">
        <property type="term" value="C:molybdopterin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030366">
        <property type="term" value="F:molybdopterin synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006777">
        <property type="term" value="P:Mo-molybdopterin cofactor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00754">
        <property type="entry name" value="Ubl_MoaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03051">
        <property type="entry name" value="MOCS2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044672">
        <property type="entry name" value="MOCS2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028887">
        <property type="entry name" value="MOCS2A_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003749">
        <property type="entry name" value="ThiS/MoaD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33359">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE SULFUR CARRIER SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33359:SF1">
        <property type="entry name" value="MOLYBDOPTERIN SYNTHASE SULFUR CARRIER SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02597">
        <property type="entry name" value="ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="MoaD/ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0501">Molybdenum cofactor biosynthesis</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="modified residue" description="1-thioglycine; alternate" evidence="5">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <feature type="modified residue" description="Glycyl adenylate; alternate" evidence="5">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW73984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="96" mass="10372" checksum="1491D230EB322C45" modified="2019-01-16" version="1">MSSSTKAPAGHFTILYFASASSHTSKSSEFFAAPLPISKLFPKLEDQYQGFKAKVLDSSLVTVNLEYVDIPDTPAEDEFMIKEGDEVAIIPPVSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RNF2</accession>
    <name>A0A3D8RNF2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ras GEF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_06418</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RNF2"/>
    <dbReference type="OrthoDB" id="28357at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00882">
        <property type="entry name" value="Ras_like_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF348">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR RASGEF, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="493"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="737"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="123"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="347"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="636"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="25"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="391"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="685"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW75597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="991" mass="109843" checksum="E96F1B4366B3CB2A" modified="2019-01-16" version="1">MDDVILRNKSKPTRNSIAIPETRASRSSSTLSSFFSPPSSPNTPTSTTTASPSFFPRPRPRDSRPSPSRVISAPQLPASATTVVSPQGLIDGYDPRESIVSIEDDPFFRNYNYQPIDELGSATYSGRLDEGRSTEPPSSSSRSLSVKETKHITLPTRNAMADINIAVIGSGGVGKSTLIQRALGLRAIPANFVSSQRMPVEGVVYMVNLIELDLESFDIDPDRRFQWPKQIGGHAVPRIDGALLLYDVMNRESIAELPQTLNALVNSSMPTILVSCKCDNPESSRQIDVESMESACLSSVEAVKTAANVPETARNCLSTMLKAIMVSRNTSGGSVSKPVGARRRAISSANLEKPLDPAIARPLSQQSKHSRASSEFSMVKGLPSPPLPSPRGQTPRHQAGRTNLHQFTIPDPHDAPPLSAHPAFRQDNFQDSSESSASSIFPQTSSPAIPSPGYGKTLEDSLVESEATDGDSPYRYSDDVPILQRGEDGFFDKPAKVAGVTFDELVERLLSQNMTRADRNFSDIFLCLYRKFAAPGELFAAILLRLEHIADDKNIHYLTRTATQLRIIAVVAKWVSNYPGDFASPTTSRNLNAFINHLSCEPVFAAAAQEMRIQLQSRVVVDDDTGWARTDADVENEMNSAAESSPSSPPPPKASILSGLDNDIGNLDLNEESTEEEIARKESTTESASSARAASPTYSITPSFHTVEDYEKEAATMVPRKTLPLTKFRYHIFMDTPEDDVADEMTRIDWVMFSSIRLRDLVRHVSLPLEIKEKSKNLANVNRMINHFNHVAKWVANMILMRDKAKHRAQMLEKFMTIALKLRQLNNYNSLAAVLAGINGSAIYRLNQTRALVPAEVHKRFYRLVMLMSPQKSHFSYRLAWENSSLPRIPFIPLTRRDLVSAEEGSRTFVGVTGDRINWKKFEVLSEVILPIMKSQVVPYPNLQKHDIARELILDCRMPTDDEEIYQRSVQLESSSGSVEPGKKKFPWFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RP00</accession>
    <name>A0A3D8RP00_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BP5796_06556</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Cell cortex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
            <location evidence="1">Centriole</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynactin 150 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000132">
        <property type="term" value="P:establishment of mitotic spindle orientation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000743">
        <property type="term" value="P:nuclear migration involved in conjugation with cellular fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022157">
        <property type="entry name" value="Dynactin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916">
        <property type="entry name" value="DYNACTIN 1-RELATED MICROTUBULE-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18916:SF6">
        <property type="entry name" value="DYNACTIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12455">
        <property type="entry name" value="Dynactin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00845">
        <property type="entry name" value="CAP_GLY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-0132">Cell division</keyword>
    <keyword evidence="10 13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-0243">Dynein</keyword>
    <keyword evidence="7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="15">
        <location>
            <begin position="25"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="76"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="1051"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="134"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="258"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDW75735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1323" mass="148043" checksum="BDD29A4F29F4FDCF" modified="2019-01-16" version="1">MSDYAVGQTVRLSDGRVGVIRYIGQPQGIPPGGWLGIELEDYSGKNDGSIHGESYFECEPAKGMFVRPASATIIAQPSPVKPANGVAKKPARPASTTSAGLGRRTNSITDSATGKRASMNAASPSPATRRPSSMLRSPTKSPTKQLASAATSGTSSPRTGTPSRTPSITTTRPRPTVGTRSSMGPPAKPTTGRRESLVGSTGVGNRLGTPNRTTSASSRTTLAPKSALRPGVARLTSAGSQPSTSAASEGSGQDTQDEDRSLSSSKSDRDDTLSPKAVSPGMARAAAPVKNAASPARTAGTTTAASREIEDLKTKLRLMEKKRMEDRDKLKALEKVQAERDKFESIIQKLQTKYQPQQQEITDLRKQIKESEARFEEIENIQAEHDLVVEMATLDREMAEETAEVLKGELEALKQKTEELELEVEILREENTELSSGMSPEEKTSQGWLQMERNNERLRDALLRLRDMTQQTEAELRDDIKSLEEDTRELATVKEHYETVKEKLAQSEAGIEDLRQQLDNALGAEDMIEELTERNMSMSEQIEELQVTIEDLESLKELNDELEINHVETEKEMQEDIDFKDSIINEQIRRAVQQEEALDDMEYTLSRFRELVTNLQTDLEDMRASHAVTETESEQLNSRSRAMMDLNMKLQVSAAKTQVKTIDLELRRLDAQEASEHLSIVQLFLPEAFHTDRDSVLALLRFKRVAFKANLLHGFVKERVSGQVSRGHEDDIFAGCDALDKLTWVSAMCDRFVNAISHCSTDEFAKFEGALYELEPVERALNNWIDGLRRDELQEKQCATELQRTIALMSHLAEVHISSGLGSYADDIHMRTIIMQSHLENAATALASAKTMVQAIIPSQGDEDELAQHFANKTDAIISQTRNAKVIVGKAVRSLEDLKSRSLSLMPDTLQSFEQCETWTEELASFTRHMGDDLFTLLHEEGRAEPYNFLEVQSTIHRTTSAVFSSSESDLFSTYSNKLRTLNTSLVDLAAMASDLEMTQEFERAPAPWVLRSQELKSSKTVSIDAEEEMRRLKDDNHERARLIAMRDQTLEESSVKIELLESRMRDAAKKNERINELEKKIEDAQKREAELAESVETQNKELAAMEADREKWKKIAGDTKTIEVTAGSKAGQERAVATAREMEALKTEISSLQAAVRYLREDSRRARLLEPQTLDWLEAPLTTPVSKEEQRKALVLSEGQEVLNELLNLTTNTKIYDLSAMPKNRLAWRPAKSTPQYHVAKQRENYESWSSWRDAVVKKGQVLAERDNNILMNAEKRKRGHMAAKVKLRLPDWEEKGAGRGREVYIVDPNGFEEFQEKLGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RP63</accession>
    <name>A0A3D8RP63_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Allantoate permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_06616</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RP63"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF10">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW75795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="471" mass="51557" checksum="093B2DF74DDE97BA" modified="2019-01-16" version="1">MDSNCSETEPLLFETRTESVRTFAAEDPKLNVATPIHTDGREDLAEAAVAKKVLRKIDWRLLPILFISSNFNFIDKSILSSASVFGLSADIHLHGKQYSWVSSMFYFGYFFWEYPTTVLIQKLPIGTYVAGDIIIWGAIVAATAACNSFGGLITARFFTGVVEATISPAFLYITAMWYTRDEMPSRMAMWYAGNSFGGAIFGVATSVWGIIVLLLLPDTIATAKFLTEDERKYAEERIAKKGAGVTMSIKNEWKFEQMPNGGTQSFANLVLKGFGFTSLQSTLVGLPASAISFSCILLTGWLATKYRDITTILISVMILPPVVGAALMNWGGHNGVKLLGYYLLGFAHGAIPLTMSLIGSNTKGITKKMTMTAIMFIAFCAGNIAGPQLFISSEAPHYPTAFKSILICYALASLASLGLRFHLTWLNKRRDVTEGVDVTNTVAAPFPGAAVADVDYEDITDYNTIGFRYRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RP82</accession>
    <name>A0A3D8RP82_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_06636</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RP82"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="97"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="13">
        <location>
            <begin position="133"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="215"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="237"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW75815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="463" mass="52528" checksum="56A6D3DFD4EFE04B" modified="2019-01-16" version="1">MPLIWLFGTRNNVLLWITGWDFATYNNFHRWVARVSTVQAVVHSMAYTISIFRDGGWLYFMKFLSKRYFLNGEFATVAMVAICCFSVYGLRRSYYEIFLFLHIILSIVVLITMWYHVEIFDGEYDGFIWPCVYMWLFDRMLRVLRILSFNIKFWSTEAIATYDSDCNIVRLAVPYTKSLLEPQPGAFYYVYVLNSRKFWESHPFTLAYATKDEDSAEESRAPSPSLGTITPPHRVSTPASEPESSVSTPVASGEMSTLLGQSKASAPYSMTFIIRPYDGFTRRLKESAQQTVAKSRVLIEGPYGHTLPLHKYQNVLFIAGGTGIAMPLSYITSLLLPTSSTISSLHIVWAVREHEFLDQVIKTDFRGSLDDERLILSAYITRPREVDKSDEEIPAYPKALSVFHGRPNVRKEVEDMSRDARGEGLAVVACGPGMMADDARAAVVGVLGTGKVGVDYFEESFNW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPH4</accession>
    <name>A0A3D8RPH4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_06813</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPH4"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13395">
        <property type="entry name" value="ASKHA_NBD_Arp4_ACTL6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000375">
        <property type="entry name" value="Actin-related protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW75992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="466" mass="50805" checksum="E61FAF13022AD851" modified="2019-01-16" version="1">MASQTMNSSMQPTDVYGGDEVSAIVLDPGYTSVRAGFAGEEVPKSFVSAHYGQIGDQLIFGDNEIHNYKPGMEIRNPMGKDGVVEDWDVATKLFEYSITSRLTRFPQSDPRSNGLNDDPKDADVEMDAVEEQEKTLEEHPLLMTETAWSTTKSREKSIEIAMENWGCPAFWLARNSVLAAFASGKATALVVDVGASNVSVISIHDGLILKKSIQKSPLAGNWLSSQLRSLFGSVEPKVDLVPHFMVRSKTPVDAGAPAQAIYREFKIPPTASFRALEEDRVLTEFKESVIQVWPGPGRLSSGTGPGSTNEDVARSQPGRVFEMPDGANQMWGLERFKVGEGMWDEKAALPVAGEIPPTKAQTIPEMIKASLGGVDMDLRPTLLQNVVVTGGTSLISGFNDRLNAELTVLYPGARIKIQAAGLTSERRFGSWIGGSILGSLGTFHQMWISKKEYDEFGANVVEKRCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPJ2</accession>
    <name>A0A3D8RPJ2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_06625</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPJ2"/>
    <dbReference type="OrthoDB" id="4657524at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054508">
        <property type="entry name" value="PIR1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018620">
        <property type="entry name" value="Ubiquitin3-bd_protein_But2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39613">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39613:SF1">
        <property type="entry name" value="ANCHORED CELL WALL PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09792">
        <property type="entry name" value="But2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22799">
        <property type="entry name" value="PIR1-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017758594" evidence="2">
        <location>
            <begin position="16"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Cell wall mannoprotein PIR1-like C-terminal" evidence="4">
        <location>
            <begin position="61"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin 3 binding protein But2 C-terminal" evidence="3">
        <location>
            <begin position="392"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW75804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="544" mass="54807" checksum="2060BC9B57F9A701" modified="2019-01-16" version="1">MYSLVISSLVLGASALSVPRSSCSFGLTASGGQSGTIGQLSDGQNRIGGGLDAATFTISNGGITDAAGRGCILTPSVEQFQCDQGVGPTYGFSIANNGSLISPVSGSTFYACPASDTEWNLYTTPVTGQLKCVEISLTASDCGSSAASSAAAIQTVTVTVQGDCGASASSPAFVSASVQSGFPATSSPEAASSAQAVTTQSTEFSAVPSTSVPAQYSSPAVGPVPAQSASSEVVSSIPVDTATSVEASTAPVQATSPTEVSTAVVTSSAVTESSVTSYPTPSAETSSYEATTPAVTPTSLSSSALVETSSYAVTTPVVSETSAAPTTSVTSTTTYSIANSTSIWTTYVTSTAPLSSYSPSVSPSSVESSSVASASSCAATTLTGTYTNGNYQYPHLIIPVSSETPDTAAGTQYFGTISSNTSTIFNFDIPSSYAGQTCNLIFLLPLQSQLETSSYTFSGTGSIDFSQLSSAASSATTFDNAPSVESDLGTFTLIEGSSTLIKSFSCDAFAGTTATYEMSAVGDTYLYYFQDWNPSPLGIYITVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPL3</accession>
    <name>A0A3D8RPL3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glycoside hydrolase-5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_06719</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>alpha-D-galactosyl-(1-&gt;3)-1D-myo-inositol + sucrose = raffinose + myo-inositol</text>
            <dbReference type="Rhea" id="RHEA:20161"/>
            <dbReference type="ChEBI" id="CHEBI:16634"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
            <dbReference type="ChEBI" id="CHEBI:17505"/>
            <dbReference type="ChEBI" id="CHEBI:17992"/>
            <dbReference type="EC" id="2.4.1.82"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolases 36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPL3"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047274">
        <property type="term" value="F:galactinol-sucrose galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000222">
        <property type="entry name" value="Raffinose synthase Sip1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008811">
        <property type="entry name" value="Glycosyl_hydrolases_36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31268">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31268:SF32">
        <property type="entry name" value="GALACTINOL--SUCROSE GALACTOSYLTRANSFERASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05691">
        <property type="entry name" value="Raffinose_syn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW75898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="902" mass="100552" checksum="F3D5C67550431720" modified="2019-01-16" version="1">MAEDSFITSDGMDVFQAKYIPKQKSHSSDHTAAMKAYISTYPSMGRITQIGKSTTSFTALLEVDESRASDPWEVSIWHSDGSDWKESPMVPLEAALHPFSLGSPSTKGLTRLYFSTPLAIRLPTTFTIKFRQGPAQSWKWLRDHQGTQDGIALLQTVTSQDTFSSTLADYVENLNPELDSKNFRSQSPGTTLWSVEARIDAANGEESMIKDIRFGLPWGKGKFLRWFALVRIWSPWLAPRQGKNHFQLDKEGILCSFVSSEGKHLVMLAISGVDNVMTLFTSDSDGNVVLKVRNDGEDAAVARVLVAVGDDFESANAAVMYHARGIVATAEELSGEASKEMEALKDGVRPEWLENWYDGLTYCTWNALGQQLTEEKVIKAVDTLAEHQINITNLIIDDNWQDIDYRGHGQFQHGWNGFEAEPVTFPNGLKHTVSRIRDKHHSIQHVAVWHAILGYWGGISPDGKIAKNYKTVQVVREDAERRNLPLGGKLTVVAAEDVPRFYDDFYRFLSSCGIDSVKTDAQFMLDTIVSAKARRELIPAYLDAWNISTLRHFSVKAISCMSQTPQILFHSQLPQNKPPVMVRNSDDFFPEIPASHPWHIFCNAHNSLFSQHLNIIPDWDMFQTVHDYSGFHAAARCVSGGPIYITDIPGQHNIDLIKQMTGPTTRGKTVIFRPSVIGKSLDQYNGYDDDNLLLIGTYHGPAITGAGMIGVFNISQRPLTELISLSRFPGVVDSQYYVIRAHTSGKVSQPLQVNDPSALMHVSLDIRGYDILSSYPLRGFVDSKRDETYWIANLGLIGKMAAPATIVDTTMTMQDTGRISISTNLKALGVLGLYISSLPSLTIDNNFMVTILDKVIPVHTVSISKADPYVLEIDAETAWHELKLGSRWSNELEVKVTVIPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RQB6</accession>
    <name>A0A3D8RQB6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative fatty-acid amide hydrolase 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_06957</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RQB6"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF3">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="5">
        <location>
            <begin position="81"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="134"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="3">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="230"/>
            <end position="233"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW76136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="543" mass="58893" checksum="273CE073EA3E8226" modified="2019-01-16" version="1">MSESKKDYRSIAAGKKLQQNGKIPKDWLLSLKEYECSSNFIGVPTTCGILTDVECKITSEYDGTALLEKLKAGDLSAEQTTVAFCKRAAIAHQLCNCLTEIFFDEATERACQLDQERKSGKALRPLHGLPISLKDSFQVKGYDTSTGLGCFVNEPAEENSSLAALLLDLGAILYCKTNLPQSIMTGDSDNNVFGRTLNPRNTFLTAGGSTGGEGALIALRGSILGVGTDIGGSIRVPSLCNGIYGFRASVGLVPHGGVRDLSVPGTDGVRSSAGPLATSLRDCALFLKTIMQTETWRYDSTVFSVPWTDLPSKKRLRIGLVRDDGIYTPTPPIRRGLETAADLLQKSGDVEVIPLTLPNTVGVYMDFIQYMALLGSDHYLELFARTEEPVIPSLAVTPLLTLKGTDLRGFFDLNVRRAAAAKSYLKLFLDNNIDAILMPVAPHTAVPFDSWSGISYTSLWNALDFPAVVLPVGKVQDSDLPDDISNATYGPQDTEVYSLYTGPERYKDAPIAIQLVGYRHRDEALTNTATIVDGIINDKKARN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVV6</accession>
    <name>A0A3D8RVV6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_06049</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVV6"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF147">
        <property type="entry name" value="CHOLINE DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="279"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="527"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW78197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="591" mass="64701" checksum="33D1B965CF108898" modified="2019-01-16" version="1">MEYPKLGDFKGKDFDYIIVGGGISGCVLANKLVLAGSSVLIAERGPRGEIKGQDVPGNFLKMLDSELNWRYQTTPQIGLNNRVLDGYRGTGIGGGSRLNYMSWVRGPKADFDDWAKLVGDESWCWDNVLPHFKELETLEEYVAEELREYVQYDRVNHGYDGPISVGTGKEALPGARDFIKACMQAGIPLNKDHNSGNPIGVSVAQLNCPNAVRISSARAYLSEEFQKQHASQLSILCQAMCSRVLFEANKAIGVEILDVQNPDEKISVLARQEIILTAGTYGSPHILLLSGVGGRAQLEEFGIPVVADVPGVGQGLQDHAIFSCEYLQDSAIPSYNHFLQDPKMMQPAVDEYESKKTGPLVKYGGAASIACPILDRLFTSDEYLALPTDVQEFLKAPRRPSTEYWVMSGPLYYKGGDLKSTDSVIAHEVLLQNCQSKGSVRLASANPAIPPLIDPNYLGHPYDVRMAIEVLRQLLKIAQTDVYQRVLRDTLVGPWPDIGNLQEIDADSLPEQILEEFARSTICQGLHAVSTCSMTVADNALGVVDVDFKVRGVEGLRVADISVCPVLTSNHTQVNAYLTGLKCSVKMLSCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RX14</accession>
    <name>A0A3D8RX14_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_06203</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RX14"/>
    <dbReference type="OrthoDB" id="10581317at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW78351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="174" mass="16764" checksum="B4C9A059454EF218" modified="2019-01-16" version="1">MYALTVAKMVVGGLVIGQGVLAYAGPTIEITLEEYAELKALAKRDACTPATVTLCDTSVPTPTSVPSTVVPASSAPAATTPSPAATTPAGVPATTPATTPTTAPIVVASSSVSTTVVASSTSTSTVASSAPPTTASTSAVASATPSTTPSSSGAARKVVPATMALVLMAAIAFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RX63</accession>
    <name>A0A3D8RX63_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_06276</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RX63"/>
    <dbReference type="OrthoDB" id="2126185at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW78424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="524" mass="57256" checksum="C3BB9ECB0CE332C0" modified="2019-01-16" version="1">MAPVDLEPSTSVVPALTRGSHILLAAGLTAIAGRSIFRSYLTLPPSSTTRHREPLRRGHVKLFSALALLSGVTAMYYGSTFAWLSYQVWAGERGIELPNSFFGDNGAFRGGEHPGRFQLVRWLNDTPLYKDAFEIVAGKARYFWWGQQASLSTLSWSTFLAIEGKRRKISNLWAFLLLGQLVSLSYGQNLFFVATLLTPVPLPDNVTSLTRSSVPATSSRFARLKSKILLAKPDGWLPHPAFYIMPLLVSLGAVVLTPYSVNSPFFMNIALLFQALPSINILLPYLIPESWGTTHTHPHSAQKTYTTLFRTISSLSALLHLKSTGMALFYSTPSSEYYHPTLLHPLNHEHRSTLDRSSAAIAKLFGAIGEHPAVSAVGYDVLLSGVSIGLWTAIRSLDPTDLLSSSIPFVGGNTASSLVEEAKHEPEEESTMVETSPKKRTRGRPKKAEPLATSNEVRVPKTRRRKQAEPDSAYQPTADESRIEGDEEAMEDDWEAAALAWGLISAGGLGLGSCGVFGAECVAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RXB2</accession>
    <name>A0A3D8RXB2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_06326</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RXB2"/>
    <dbReference type="OrthoDB" id="71302at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11398">
        <property type="entry name" value="bHLHzip_scCBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047206">
        <property type="entry name" value="bHLHzip_scCBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47787">
        <property type="entry name" value="CENTROMERE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47787:SF1">
        <property type="entry name" value="CENTROMERE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="4">
        <location>
            <begin position="146"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="54"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW78474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="260" mass="28395" checksum="6CD09B2C6A5306BF" modified="2019-01-16" version="1">MSDMDLEHSGLQEVANAVRGDVGSESNSSQKRKRDPSDQGVSADASRGLRNKRVSPNDSGDQSVESLQDFTNHGNPDQNGGSDNAAATAAAALGGVYPTMTIPQPTDLSFATQDSEERNDPSFMPDSQDDRFMNRDMHTTTPMSGRGTGKPAVVERRRRETINEGINELAKIVPGCEKNKGSILQRAVSFITQLKENETQNIEKWTLEKLLTEQAIAELSTSNDKLKAECERAWREVETWKKTCQSAGLAPKKDDGPGDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S240</accession>
    <name>A0A3D8S240_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450-12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_05036</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S240"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11040">
        <property type="entry name" value="CYP7_CYP8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053007">
        <property type="entry name" value="CYP450_monoxygenase_sec-met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47582">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47582:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW80338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="532" mass="58526" checksum="AD0161FB2DBD3BD7" modified="2019-01-16" version="1">MAASQIAAGESLVSKFTSGNVLILCGVIGGLYLLDFLLTPRLDASEPPLLKPSIPLIGHIIGIIWHQTDYHRIVHKKHPIPIASLQMLWGKIYTVWDPQLAQASLRTRNLSFGPFVVEFAQKAFGLSAETFAKITDNKDLVPDFTEAIHAGMQPKCLHAMNATALNHISRTLDKVSPDDEGGVAVPNLYLWVRDAITFATAHSLLGKENPFENNPSLVEDLWTFEGSLPHLLTKPFPTITVRKGYLARNKLQAVLGKYYTAMHDVNDPTVAQLTRGRANVLRGYGFSGVEVAQAEVMLPVAATTNSVPTMYWLICSLFAKPALVDRIREEVLPLLEKGGDSDPDVVTINISRLERECPLLVSCYREIMRLFNQNVSMRRILADTTINDGKGNSYLLKKGVDVQIASGIVHRMQGIWGDDVLEFNPERFLPPTGKSAGQVEKEKTKKNAYIPFGGGQHLCPGRNFALAEILAISSALVVGFDLTPIGMDFDQMKAQPAVLANAVAKPANDGEGLGIKLRRRKGWEAAEWRFEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2N4</accession>
    <name>A0A3D8S2N4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_05059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2N4"/>
    <dbReference type="OrthoDB" id="3468019at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW80361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="16414" checksum="AF427B5C5221701D" modified="2019-01-16" version="1">MATDYTFIHPPTLDPVIKDHISSLYRTVDIGPESAQAWAAHFAEDAILKKSPNEIKGRENLEKTIAGSWAPLKSRKHIVYKVFPFGDEDGKQEVMLHGRSLNEYKDGTDGTFTWAARLRFKKVADDKVLVERYTIIVDPTPALEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3W0</accession>
    <name>A0A3D8S3W0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pyrroline-5-carboxylate reductase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BP5796_05691</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-proline + NAD(+) = (S)-1-pyrroline-5-carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14105"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-proline + NADP(+) = (S)-1-pyrroline-5-carboxylate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:14109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="EC" id="1.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Amino-acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3W0"/>
    <dbReference type="OrthoDB" id="10263291at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3730.10:FF:000001">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000190">
        <property type="entry name" value="Pyrroline-5-carboxylate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00112">
        <property type="entry name" value="proC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF0">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="13">
        <location>
            <begin position="11"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="14">
        <location>
            <begin position="179"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="14"/>
            <end position="19"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>NADPH</name>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="76"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029440"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00052690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000193-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDW80993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="292" mass="30618" checksum="BE7E8C32DE34EF5B" modified="2019-01-16" version="1">MATSQIKDCQLCFIGGGNMGAAIIGGLLAKGSTSQQNVIVSEPWEVNRKKVEESLGVRTTTSNIEAARDANVLVLAVKPQVAKGVCQELAASWSDSNRQQLPLVVSIAGGITLNALTQWFTVNDGRTPRVVRVMPNTPALLGEGASASFAGAGVSEDEKKLVTELLEGFSKVTEWVDREELIDVVTGLSGSGPAYFFLLVEHMVSSATALGLPKEQAQRLATQTCLGAGRMLVETSESPAQLRINVTSPKGTTEAALKSFAESGLQETVNVAIKAAVDRAEELGNAAFASTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3Z5</accession>
    <name>A0A3D8S3Z5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative branched-chain-amino-acid aminotransferase-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_05492</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3Z5"/>
    <dbReference type="OrthoDB" id="409992at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004084">
        <property type="term" value="F:branched-chain-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009081">
        <property type="term" value="P:branched-chain amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005786">
        <property type="entry name" value="B_amino_transII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825">
        <property type="entry name" value="AMINO ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42825:SF2">
        <property type="entry name" value="BRANCHED-CHAIN-AMINO-ACID AMINOTRANSFERASE 3, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006468">
        <property type="entry name" value="BCAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="6">
        <location>
            <position position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR006468-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW80794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="359" mass="38827" checksum="536D29F763789562" modified="2019-01-16" version="1">MEAANFPLPPLKDVDWDHLGFEPVEVNGHVECTFSSKTGCWTEPEFVTDPYLRVHGLAPGLNFAQQIFEGMKAFRSPSGEVQLFRPDQNALRFARSARCVSIPPVPTELFLRAVNIAVGMNTEYVPPHSTGAALYIRPIAFASSPTVGLFLATQFTFCVYVLPVAPLHGKGVDKGADVLVIEDFDRAAPLGTGSVKVGGNYGPVLGLIDDAKKQGFNLTLHLDSLSHSLIDEFSTSGFIGVLNDGGVPTLVVSDSQQVVPSITVDSICDVARGFNWHVEKRPIPFSEVARFSEVYAAGTAAVLVPIGSIRRRSSGEHIIYPVDYSSATSCFFRLSKALGDVQQGVVPDHRSWIALITKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S442</accession>
    <name>A0A3D8S442_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_05559</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S442"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF4">
        <property type="entry name" value="CYTOCHROME P450 98A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW80861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="533" mass="59853" checksum="42A4ABD0C7D3AC29" modified="2019-01-16" version="1">MPLMSFFPSWYTVACLAMVPIAVLLSDAWKWLRMPPGPTPLPFIGNKFQLPQHKPWIKFQEWSHAYGPVFTLWVGRRPTLVISDPLVAVELMEKRSHKYSSRPRFVVMGEILNNMASILVQPYGKEWSLRRKLLHRALTPAALRSYMARQEAEASRLVLQIMSNPVEWERAFERFTSSVVFSVAYGHRIDSLDAAVIQDRMRFMHYQASLNVPGAYLAESIPILKYLPRFMAPWKRDVEDHGKLEVAANMALVQDVIRDLDQGTEKGIEVAQSLTRTLLETRAKEGIALSDKDFSFVPASLFGAGSDTTASTLCTAVLALVTNTPILRAAQAELDTVIGSARTPQFSDEPQLPYVRALVKEVLRWRPVAVLGGTPHASTEDDVYEGFHIPSGTTILGNSWAINLNPTYYPSPQTFDPARFLSATDPGVRRDLQGSPHPSKTGHSSFGWGRRICPGADLATNALFIALAKLLWSFDILPLPGRVYDTFDYTDGFNIRPKPFPCQIVLRSETHRLVLEREMLAAEHEMAKFPAYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S9C1</accession>
    <name>A0A3D8S9C1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 9">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_04446</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW82955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S9C1"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0274">FAD</keyword>
    <keyword evidence="3 7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="8">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="9">
        <location>
            <begin position="296"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="258"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW82955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="621" mass="66287" checksum="D865A114536AFF61" modified="2019-01-16" version="1">MAAPALPALVSLEAFLKNEYDFVVIGGGTAGLAMAARLSENPAVKVGVLEAGPALIGDPMIMIPAMYVKSVGDAKYDWLHKTVPQPSAGGKSLDWPRGKCLGGSSAINFLMYVRGQASDYDDWARLGNEGWAFKDLLPYFKKHENFQDPKDLQKQPNMALETRYDASVHGKLGPISTSFGEYRIPPERDWVAACATLGENMGSPLNAWSGDHLGNYHSLSTIDRRPGEMNGTRSYSTTGYLLPNAQRPNLFVLTEALVTRIILSSDKVATGVEFLHSDSDEKHSVSVKKEVILSAGAIKSPQVLELSGIGSPEVLSKAGVKCLVENRRVGEHLQDHSAVAFGYELIPGETTLDAVQDPATMQAAFGEYMAEKTGPFASAGSTMGFASFAGLSTPEEIKSIQDSILGSGDLDIQSKAIIAEGLGSLKDGSIQFVLLPASLDVEKTYSQTAFLQPPTSQLGGKQGLVLAACVARPASVGSCHITSAEPKADPAIDPAYLTHQSDVEVLIKGYRLISKMVSTSPLKEKIAKRYGPDESLDLSTHEAAEKWIRNHVATEYHPIGTVGMGKEGVGAVDSNLKVYGVKGIRVVDASVFPLHISGNPLATVYATAEKAADLVKAEWAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S9E7</accession>
    <name>A0A3D8S9E7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW82903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S9E7"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW82903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="146" mass="16111" checksum="ABBC0F03A775833A" modified="2019-01-16" version="1">MGLNGRALLPAGTAQRWKMGSSTRASEEEPDLWSANSKSRTSFEHSDAANQTKQAHGRLGHHGPSPVCPPADVIAWRREKMKQHSIIARRSSGKISTKRAYPSIRLSRRRGFMPSPEGFYVDRGPRHRISSVHAITVMAARTASAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S9N4</accession>
    <name>A0A3D8S9N4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04474</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW82983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S9N4"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW82983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="82" mass="8673" checksum="EF74418997462655" modified="2019-01-16" version="1">MYVLDRVMSPLQDASTTTGPLTTPIVPTVTSSVTTTLTATASSSLASRNSAAQVTSAVIALQYLWQWGTQALLVGTLKRRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SA12</accession>
    <name>A0A3D8SA12_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SA12"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW83175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="156" mass="17567" checksum="776B85F493E3BCA9" modified="2019-01-16" version="1">MEKDIAEQSHCLERPKEQRRIGILSIASVREKVARLPTAGILMTLICLLLVLDISVRYPTSAGYCSRKLSLPTPLAEPAASPRENKFFNNSLTTGGSPWRQGPNNEVDLMWKSIIQENLIAISDDQVRKLGKDPAYFRRVPRDLQAKYGDNLSHHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAE2</accession>
    <name>A0A3D8SAE2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Preprotein translocase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_04721</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAE2"/>
    <dbReference type="OrthoDB" id="1734229at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000039">
        <property type="entry name" value="Protein translocation complex component (Npl1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075">
        <property type="entry name" value="SEC63 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075:SF0">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="11">
        <location>
            <begin position="106"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="640"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="671"/>
            <end position="700"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW83230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="700" mass="77769" checksum="87842317520A7BDB" modified="2019-01-16" version="1">MSSTDYSYDDQGQFFPFFIITIVAVFTLPLTYNVLKPSSEPGATAPRIKTDFRPKHAVLIDEQKRAQKKRERKLKRGIAVVVGWAVMFFMAYLIVVTARTQTKIWNPYDILGISESATEKAIKSHYKRLSLKFHPDKVRPDPSKNITLESLNDRFVELTKAYKALTDEDIRNNYIQYGHPDGKQSFSIGIALPSFMITEGNGKFVILVYALLLGVLMPYTVGVWWYGTQALSKEKVLIESANNLFKEYDERTTEGGIITALSTGAEFKSILKGEKAESGQDKLEARILAEGEATPLAGGLTIKDRAKLEDLDGGVRRKALGLLWAYLGRVELNDQALEQAKVEVAPIAHALTQSYLAIAMAYGTVGPILNAYRTMQCLVQAVPPTASPLLQIPHFTPATVRAVEGDARTHLTVQQYMQIQEARRRSMTVGKGLLTESEYDTAMKVVKQLPRFQVEKVFFKVAGEKYITPGSLAFAVVKGRFVPPGSTNVPEVNELDLEDIDPAEDDVDAILGRKKTPAKGEAPVADDKPSQPPLAFAPYYARDYSPRWHLFLTDSKQDKMAVNVHTYTQFEKPIFDESGAPTYNMQTMKASFQTPPQAGQYTFVLNVVCDSYVGFDTKVETILTVDEASKAEEIAIEDEISEPDEDSLAGQMSMLKNGGAPPPQRRKKAVEDDDDDSDESNTEGEVDDDTSETNTDTDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SH68</accession>
    <name>A0A3D8SH68_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_03968</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPL family. K-HECT subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="423283at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045322">
        <property type="entry name" value="HECTD1/TRIP12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057948">
        <property type="entry name" value="TPR_TRIP12_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45670">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TRIP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25579">
        <property type="entry name" value="TPR_TRIP12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="1473"/>
            <end position="1829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="701"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1047"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1167"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1268"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="730"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="760"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1047"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1065"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1188"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1279"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="1796"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW85643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1829" mass="199002" checksum="46EFEE0F83E46517" modified="2019-01-16" version="1">MSSRIIRRSARVAASSSDSGNPAPTVPSAAAPSRPPSRKRKASVREPSPAPEPEPAKASSTRRPKRQKVVEPERSAPAPAAPARKKKGQTAAVMSSPSASSGPSNETPAPSTSSTRRKSTRNKKLNQDASTTTPSSGRRSKKGNSSKDADAVDNESDDRPSNAEEDGSGDNDEEMNNDYDGDGDGAEDEDDDPFGGFGGPGGPPHGLSSTLRALSGMMSGVSTRLRDILNNLKQKDDPSMQLIALQELSEILLVSTEDNLSGHFSPDSFVKELVVLMQPSEFGEENPEMMLLACRCLANLMEALPASTANVVYGGAVPVLCQKLLEIHYIDLAEQALSTLEKISVEYPASIVREGGLTACLTYLDFFATSTQRTAVTTAANCCRNIPEDSFPVIRDVMPILLNVLSSSDQKVVEQGSLCVSRVVESFRYHPSKLEELVSTDLLKAILRLLLPGTTNLIGPNIHTQFLRVLAFTAKASANLSAELFKMNVVETLYQILTGVSPPSADEDIASKLDSVVIMQALIHRPREQVIETLNVICELLPEVLRESDAAFEGIFDLDPSAAPASSRKKSANEKRIELLEGCKAEVKRFAVILFPTLTDAFSSTVNLSVRQKVLTAQLKMLSNLNKDILMEALRSLPYASFLAAILSQKDHPSLVNYALQAAELLLARLDDVYQYQFYREGVVAEIAKLAASDHRENISNNASEVASAPGADEAGTEQRINEKSANGENGDDADDHSSDDEDNDDENENDDNPEDVSASPASSRGSTMSMDGPPRHIPSDLTSMQHLIAQRAQRFLDVHETDDNGKDMKKKATKILTDLQTLATKIESFYLHQGPGNGVELFTTLASHFEGDVLESVTSAELLNSEVVRVLLEVFNNPDEKLSNDARSAFLEVFMGRTAKNKPQTASADSPATPFSSLIHKLQDLLSRSEHFEVVTVHQNTFDGNRSSAASMLAKQIRLKLVADDDSEIPRPYRNIMVSIHAIATFKALDDYLRPRISLSERPRGARSREGLSGALAALAAAGMPLPYANGPGAASRLAERASAAAGSVPAASTPRTTRKSKSKSSPSAATGSSDQSSTPQERSGTRRSSRRQQMQSEPGPPPSHDDDSLANALECADERQLSDDEDLDGSGALDTILGELEDDMEEPDEAPDPGAVSLEVAAGGKITARKDDGTRVATPSQLHGGSTPSIATPQTASTSTPSAPRPMSYAAAIQAVPQDWHIEFSLDDKVISNETTIYRAVHSTSTPADEHVSRSVWSAIHPIKFKRVPGPPPPEPNSLTQQSESTAETTISGIPASLDKHPATSSILRLLNILHALNANLDDVLAENTITLKLNAEPLSQFVNTKLTAKLNRQLEEPLIVASNCLPSWSEDLARLYPFLFPFETRHLFLQSTSFGYARSMTRWQNAQSAEENRRDRHRDERPFLGRLQRQKVRISRSKILESALKVMELYGASQSILEVEYFEEVGTGLGPTLEFYSTVSKEFSKKKLKLWRETDTNDSDEYSFGARGLFPAPMSEEQASNENGKRILHLFKMLGKFVARSMIDSRIIDVSFNPTFFRIGDEAKTVIPSLGAVKTVDAQLAKSLKLIKKFAVAKKSIDENGNLSAAEKVAAAEALQVDGVQIDDLGLDFTLPGYSSIDLLPNGSQIGVTIDNVELYLEKVIDMTLGSGVQRQVDAFRAGFTQVFPYSALSAFTPDELVMLFGRIEEDWSLETLMDSIKADHGFNMDSKSVKNLLQTMSELTMAERRDFLQFTTGSPKLPIGGFKSLTPMFTVVCKPSEPPYTSDDYLPSVMTCVNYLKLPDYTDLDVMRRRMNTAIKEGQGAFHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHE9</accession>
    <name>A0A3D8SHE9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_04100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHE9"/>
    <dbReference type="OrthoDB" id="2592092at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013909">
        <property type="entry name" value="NuBaID_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012935">
        <property type="entry name" value="NuBaID_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835">
        <property type="entry name" value="NUCLEAR-INTERACTING PARTNER OF ALK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15835:SF6">
        <property type="entry name" value="ZINC FINGER C3HC-TYPE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08600">
        <property type="entry name" value="NuBaID_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07967">
        <property type="entry name" value="zf-C3HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3HC-type" evidence="7">
        <location>
            <begin position="91"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="NuBaID C-terminal" evidence="8">
        <location>
            <begin position="289"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="13"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="396"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="51"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="411"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="424"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="445"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW85775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="467" mass="53011" checksum="718850E129ADD2CD" modified="2019-01-16" version="1">MNSTKRKFNALLSGIGNKSATSLKPKEVNNRTHDVPTSENDAQSKKRRISDPSSIQTQGSSEPTIQVGSTIRRKLVLKAALTTTERPKYAPWDRIAFLERLKTFSNLTDWTPKPDRVNEVEWAKRGWVCKKFERVRCCLCNVEILVKLNKKEVDGKEEPVYIAGNIGTQSAEQDANDGPLTFSSEEALVDKYVELIITSHDENCLWRQRGCDDKIFRLPLSHPQVALDQLYQRYTELEKRKDTLPYSYNLRIPPDFNLDNILSFLPVDFFTSSQEQIPEQQSRPVNRVALTMALFGWQGHTHERLGPQFGSVSCGACFRVLGLWLFKSKGVNEAGEEIEGPVVPGLHVVSEHRAYCPWRNAESQNGTKALAGESNPAVPGWEVLILVIRNHHRLTTGGAISPPSKRTYSPEESEGVAVEEDDETARSIRDQKDKERWTRMRRVKSLFEPKAKKSQKPEVNEKRKSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHW6</accession>
    <name>A0A3D8SHW6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ATP citrate synthase</fullName>
            <ecNumber evidence="4">2.3.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BP5796_04079</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>oxaloacetate + acetyl-CoA + ADP + phosphate = citrate + ATP + CoA</text>
            <dbReference type="Rhea" id="RHEA:21160"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.3.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHW6"/>
    <dbReference type="OrthoDB" id="5295093at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000004">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.110:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032263">
        <property type="entry name" value="Citrate-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056749">
        <property type="entry name" value="Citrate_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF10">
        <property type="entry name" value="SUCCINATE--COA LIGASE [GDP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16114">
        <property type="entry name" value="Citrate_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24948">
        <property type="entry name" value="Citrate_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ATP-citrate synthase ATP-grasp" evidence="15">
        <location>
            <begin position="2"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase citrate-binding" evidence="14">
        <location>
            <begin position="297"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF24948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDW85754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="488" mass="52847" checksum="28176DE096270009" modified="2019-01-16" version="1">MAAKAILEADGKAILNYHLTRAPVIKPSPLPKSSVHNPPSKLASLYFPEDADVASILDQAETSYPWLLVPGSKFVAKPDQLIKRRGKSGLLALNKTWPEAKAWIQERAGKAQTVETTVGVLRQFLVEPFVPHPDGTEYYININSAREGDWILFTHEGGVDVGDVDAKAEKLLIPVDLAEYPSNEEIAAVLLKKVPAGVHNVLVDFITRLYAVYVDCQFTYLEINPLVVIPNADATSADVHFLDLAAKLDQTAEFECGVKWAIARSPAALGMVAPKATDGKVNIDAGPPMEFPAPFGRELSKEEAYIAELDAKTGASLKLTILNPNGRVWTLVAGGGASVVYADAIASSGFADELANYGEYSGAPTETQTFHYARTVLDLMLRSPIKPEGKILFIGGGIANFTNVASTFKGVIRALREVASTLIEHKVQIWVRRAGPNYQEGLKNIKSVGQELKLDMHVYGPDMHVSGIVPLALVPGRLATSKIEEFQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SLQ3</accession>
    <name>A0A3D8SLQ3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF21-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_02963</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SLQ3"/>
    <dbReference type="OrthoDB" id="5353557at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF97">
        <property type="entry name" value="METAL TRANSPORTER CNNM-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0129">CBS domain</keyword>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="6">
        <location>
            <begin position="47"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="5">
        <location>
            <begin position="321"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW87269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="41590" checksum="676D86DBCA2B1FC9" modified="2019-01-16" version="1">MSPHPSIALHGSHQSATAAMKVLTSHAVEKIAQRGSAAAVTTVVSHDFLIHGLNAALSVTLVLMGGMFAGLTLAFMGQDLTTLRITSLSGTILERRHASKVLNVLSRGRHWVLVSLLLGNVIVNETLPIVLDSDVKGGWFAVLASSGLIVIFGEIIPQSICAKYGLGIGAWSSRYVLWVMYILSPVAYPIAILLDRLLGDTHGQIFNRNGLKALILLHERLSFSATERLNREEVTIITSTLDANDRPISSLMTPLSKLYALPIDTPLNELTRYNILNSRFAHIPIHMAGHTRSFLGLLAVKSLIALPPQSEHGEITIADLELQTLPVVRPDVSVQDVVHAFRNRDTDMVLVTERGTIHGEPLGVVTARDVLGVLIGDRKIGPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SM94</accession>
    <name>A0A3D8SM94_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mitochondrial peroxiredoxin PRX1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_03090</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SM94"/>
    <dbReference type="OrthoDB" id="2996783at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051920">
        <property type="term" value="F:peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1020.10:FF:000001">
        <property type="entry name" value="1-Cys peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000011">
        <property type="entry name" value="Peroxiredoxin PRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1020.10">
        <property type="entry name" value="Antioxidant, Horf6, Chain A, domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF4">
        <property type="entry name" value="PEROXIREDOXIN-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1 6" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4 6" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="8">
        <location>
            <begin position="9"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="7">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW87396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="228" mass="25447" checksum="575B47D0F2CB8766" modified="2019-01-16" version="1">MSSDNRAPLRLGYTAPNFQAETTNGPIDFHEFIGDNWVVFFSHPEDYTPVCTTELGAFAKLEPEFTKRGVKLIGLSANTIESHGGWIKDIDEIAGSKLTFPIIGDKTRQISLLYDMIDHQDATNVDSKGIAFTIRSVFVIDPKKKIRTILQYPASTGRNTAEVLRIVDSLQTGDKHRITTPINWVPGDDVIVAPPVSDEEAKKLFPKFRAVKPYLRFTPLPKEDTSAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMS3</accession>
    <name>A0A3D8SMS3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U3 small nucleolar RNA-associated protein 11</fullName>
            <shortName evidence="6">U3 snoRNA-associated protein 11</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_03280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Nucleus</location>
            <location evidence="2 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the UTP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SMS3"/>
    <dbReference type="OrthoDB" id="29058at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007144">
        <property type="entry name" value="SSU_processome_Utp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03998">
        <property type="entry name" value="Utp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015952">
        <property type="entry name" value="U3snoRNP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="139"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="150"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW87586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="241" mass="27925" checksum="60DE62E2BF0224DC" modified="2019-01-16" version="1">MSSMRNAVQRRNHRERAQPEERKKWGLLEKHKDYSARAKDFNAKKTKLKALRQKVLEKNPDEFYFGMMSKKGPSGKSGTVSGNRGNQELSQEAVRLFKTQDLGYVRTMRNKVMKEVGTLEKSVAGIKGNGKKIVYVEDEEEQQEKVWEGVDMEEEEDDEDDEDENEVEPTKEDIATKNFRKMQEKEADKLEAKLIIARERLKALTEAEQALDLQRARMTKSQTIGGVNKNGVKFKVRERKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SN34</accession>
    <name>A0A3D8SN34_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HCP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_03414</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SN34"/>
    <dbReference type="OrthoDB" id="27934at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF147">
        <property type="entry name" value="SEL1L ADAPTOR SUBUNIT OF ERAD E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017606178" description="HCP-like protein" evidence="4">
        <location>
            <begin position="26"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="770"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="799"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="802"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW87720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="843" mass="93562" checksum="0E792A5543BC3D09" modified="2019-01-16" version="1">MRNSSQRLWPLLLLLLQIAFPIIRAQIHNDFDTTSAERSPQPSGVAQPSAAQAAFRDQSESHREVDGAELVDQALFILRRYDRTISMNTSRKPTGLLGTLGQWMLQLIPQVSVQGPSSEGEKVHKQVKGPLFEGVRLLEQAAQMNNSDAIFLLAQMNFFGNFTHPKDYMEAFNRYQQLATISGNSSAQHMLGFMYATGIGGAVERDQAKALLYHTFAAKGGNPRSEMTLAFRFHSGIGTSRHCDTAIKYYKSAADKAMAWYRSGPPGGQAWVPDSYRLADEDGGVYGEGASFSSAGNNAQRGGVNSDAHAALDDVLEYLDLMSRKGDFKATFSLGRIHYEGQKDLPRNLKNAKWYFMKVAKLYWTREGRIIESDKPGLEKIATKAAGYLGRMFMRGEGVEQSNDKALIWFNRGLKSGDAGSQYGLGLMYLHGLGVPKNPSKATELFKAAADQDYANAQVELGALYLDQGTASDISAANQYFERASRYGHIEAYYYLAELINHGVGRDRSCGLATAYYKNVAEKAEPLLSSFAEANKAYGEGDYELALIDYMLAAEQGYEKGQANVAYMLDQQKSKWSLAPRFLFPDTRPSLLHNAALALIYWTRSAKQTNIDSMVKMGDYYLQGTGTHADMEKAAACYTGASEFHQSAQALYNLGWMHENGIGLNQDFHLAKRFYDQALETNEEAYLPVTLSLFKLRIRSAWNTLTHGSVNSIEDEPAPKKQWSLAEWITNFLQDDHPYYADSHDYLPDTDPMPGGDADGLYEDFIDDGLLESFIIIGLAAALVFLIYYRQQHQLAHRNNEDAAQNQDQQVQAPLPGQQADGGFFPRPGDPDFANWAAGGIGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SN52</accession>
    <name>A0A3D8SN52_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_03295</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SN52"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42718:SF9">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY MULTIDRUG TRANSPORTER MFSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="423"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="63"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW87601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="561" mass="59457" checksum="C36FDBFA995AD13C" modified="2019-01-16" version="1">MSSVASNAELGAGHNGGDRIQATDTLDNGNQELQPSADQRSGPSSTQVSEPDKSTGMAAAAPLVITLAGAAFLNTASITSIVIILPSIGSDLAVPQARQQWMASAYSLAFGCFLLLFGKLGDVFGRCLLFLAGGVWVTAFAIGSALSPTEICFDFMRAMQGLGAAANVPTAMGIIGATIPPGRVKNYAFAIYSAGAPVGAVMGNLMGGILGRYTGWRVVFYVLAACSAAITISAYFMIPKDFPPDTNVSRSTLVSHIDWVGALVITAGLVLLIFALSEGNDLKKGWRKPFVLASLILSILLLMAFCFWEYYLESKTTRDPLIPISLFKNKHFSVGMAIAFLFYGAFNNYLIYTTYFYQDYLLLSSIQTALRFLPCGFIGLTMVFTTGFLLDRVPANYILTFGLTSTCISCLLFAVPIPPSTTYWAYGLTAMILAVVGADSVSPCLGLFITQSLDGKDQALAGAMFNTVGQIGRILALAVATTVEGAVETAAVEVGDERQRLLKGLRYAQWLGFACCSVSAGFAVIGLRGIGRIGLTKKLESDVPGPVVETEGKDGHANTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SN86</accession>
    <name>A0A3D8SN86_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_03338</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SN86"/>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF7">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="56"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW87644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="273" mass="30499" checksum="AE9A2B816D23C598" modified="2019-01-16" version="1">MFSRKPNASQSESFSKTRRSSRSAKSSFREHAVSKNRTRRPPTDDTPSPASTLTASIITLVVGREQRLFAAHEDVLCHSPFFQAACRGQFMGASNKRISLPDEEPEIFSSVLEYLYKGDYYPRLVHNKRRNSWELETGDGGSGSPESTVYHHGVDGELLKDTVIYCTAQKYGLEELKRVALRKQGLQSGIQCSTILSSARYAYANTPDTDSKLRAHYLALIIRSRGTFKRSGTMQLEMQAGGSQLFFDLFVALCNHVDDVASIASSPRSLRHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXC2</accession>
    <name>A0A3D8SXC2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Coatomer subunit beta'</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BP5796_02121</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasmic vesicle</location>
            <location evidence="1 13">COPI-coated vesicle membrane</location>
            <topology evidence="1 13">Peripheral membrane protein</topology>
            <orientation evidence="1 13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Golgi apparatus membrane</location>
            <topology evidence="13">Peripheral membrane protein</topology>
            <orientation evidence="13">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="13">The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the WD repeat COPB2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW90956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SXC2"/>
    <dbReference type="OrthoDB" id="10261470at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22947">
        <property type="entry name" value="Coatomer_WDAD_beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000016">
        <property type="entry name" value="Coatomer alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000001">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016453">
        <property type="entry name" value="COPB2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF2">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005567">
        <property type="entry name" value="Coatomer_beta'_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11 13" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7 13" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 13" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 13" id="KW-0813">Transport</keyword>
    <keyword evidence="5 14" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="103"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="146"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="190"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="14">
        <location>
            <begin position="234"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="16">
        <location>
            <begin position="328"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="17">
        <location>
            <begin position="604"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="827"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="836"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRNR" id="PIRNR005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDW90956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="872" mass="96462" checksum="DDB891AE83191E1B" modified="2019-01-16" version="1">MVGNMVTGANSAFAIQRQLFARSERVKGIDFHPTEPWILTTLYSGHVYIWSYETQAIVKTFELTDVPVRAGRFVARKNWIVCGSDDFQLRVYNYNTSEKITSFEAHPDYIRAIVVHPSQPFVLTASDDMTIKLWDWDKGWKCVQIFEGHSHYVMGLAINPKDTNTFASACLDRTVKIWSLGSSTANFTLEAHETKGVNHVDYYPQSDKPYLLTTSDDRTVKIWDYTTKSLIATLEGHTSNVSFACYHPELPVIISGSEDGTVKIWHANTYRLEQSLNYGLERAWCVSYQRGKQGVAVGFDEGAVVVKMGREEPAVSMDGSGKLIWARHSEVISSIIKGGDASLKDNDPISLPTKDLGTCEVYPQTLLHSPNGRFVSVCGDGEFIIYTALAWRNKAFGSALDFCWGSKDNSNDYAIRESGTSVKIFKNFVEKPGGLDVGFQAEGLTGGVLLGVKGQGGVGFYDWQTGGLVRRIEVDPKEVYWSENGELVSIACEDTFYVLRFSRDNYIAAVQAGEVEEDGVEAAFEVVTDINETVRTGEWVGDCFIYTNSTNRLNYLVGDQTYTISHFDQPMYLLGYIQRDSRIYLADKDVNVTSFSLSLSVVEYQTLVLRDDMESAEELLPSIPQDQLNKIARFLEGQGHKELALQVATDSEHKFELALALGQLPIALELAREADVEHKWKIVGDAALTGWDVALAAECFKSAKDLGSLLLLHTSTGDREGLRALSGQASDAGAHNVAFTCLWQLGDVDGCIDLLTRTGRASEAVLFSQTYKPSATPRVVSLWKEALEKDKKGRVAKTVGVPGEDDELFPEWEEYLRLEKEGTVSLIDVNGHDEETSPDEEDGANTDEVINGDGPDPDAEAVVEGSLVATES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXE9</accession>
    <name>A0A3D8SXE9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">STEEP1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_02158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW90993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SXE9"/>
    <dbReference type="OrthoDB" id="418131at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057965">
        <property type="entry name" value="STEEP1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25809">
        <property type="entry name" value="STEEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="STEEP1" evidence="2">
        <location>
            <begin position="13"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW90993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="188" mass="20177" checksum="7C1E359DD40E93DB" modified="2019-01-16" version="1">MAIPAATPLAPVIYTYHCLCSTLVLATTHVISTLPRRAAPSLDAAIILPLPSALPPYTQIPITTTDSPAPKASEQENSQEDEEAETESELPSEGYTTLLSLTPDSKVVVARREDGFERRTVWRCGRCRVVVGYEIVNGEHAGGNEKPGRVLYILPGGLMTSEFMKGGKKISEAEVGIENGVAGKGVWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXP4</accession>
    <name>A0A3D8SXP4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02248</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SXP4"/>
    <dbReference type="OrthoDB" id="5224238at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="439" mass="50705" checksum="9C52724DEDB5A16F" modified="2019-01-16" version="1">MDQLPAEIRREILQLLDLDTVKALRQVSKDWAILGEEYMISSTFVTYLHRDDFGRLQSLSEHPRFPSYIRRLEFNFGEVNEYHARHNTYFMQYLQDPEYRNARLDEAWAYHGGLKTLKEAYAPKVCDPSRLEETFKQLQNLESIAVSLHNMPGFTNELFQGIWRFPTTRALPRVLTWERFTSILTAVSSSNIQLKSLSHDRLPFEFFTQRPMVISRLSTTFSNLQFLSLQLDYSDSPNAAHHQMGMDRLSQFLRSAPLVKTLHLVFQGRTKILISPLLSNLETHAASVETLSLGNKEKDSSSPTFPFLETLMLDKIATTEFELAAFITRHPTLRRLQLGGPGLVAPHHSSDGGIQLTSGTFKGLFSQLKFSLEIEKFNAQGEFQEVESSSRMQLQPVWNKEWVDLKLHERVEAKCFEDFIVRKIPWDPQWMEGVSQAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZR7</accession>
    <name>A0A3D8SZR7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_02904</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZR7"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW91739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="204" mass="23613" checksum="B94986C16CA1B27A" modified="2019-01-16" version="1">MSYTRVDSDDMRDSSRSHKRHDFSVLEVLYRVSAILTPILLTVICILLIVDYAELHKPASSSELLGTVQTRYGSNFAYMTLDHNFDDLWDEELHPQNGIIRLQDGSLSAISMFHQIHCLTSFRKALQNAREGNEIGIDFRDDEHWPHCLWYLKQAILCFADDTLERPMKVNGSNIITGQDDLHQCRDSGKLYTLREERGIWKEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0G3</accession>
    <name>A0A3D8T0G3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_01440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0G3"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW92046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="303" mass="33323" checksum="CABDBB49B7D1DCF2" modified="2019-01-16" version="1">MLDIFITEAAAVLADRQPHALATGLARTSVFELSFAGDALYVARALGLPQLRYLALDRLAMVFSDAPQLCHQGFQVVTWFCRHRLLLRSYLATAATFTPVTSSAEKIPLITILEKHARQCLDSSQLFLLRLVHLVGRFNSTTSLRIPPINPVRGGEAVRAGGGLRWELLKRARISIFTLQRPRYAVHGSTQGGLSIKSVFVESYELMQKGLPSIMNAVLASHLESTGVRPWMAASTLPRVSNSRIQGIPQWTSQSAHISSPVVVPWNPEVAESGVILGDPEKCGVGFRTIPGRSWVVMHWPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0K9</accession>
    <name>A0A3D8T0K9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_01468</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0K9"/>
    <dbReference type="OrthoDB" id="2283488at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000009">
        <property type="entry name" value="C6 transcription factor (Gal4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW92074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="668" mass="75355" checksum="4295725142E90ADF" modified="2019-01-16" version="1">MSTEYFSSSPWKCDACRARKFKCSKEHPVCSPCAKQGKTCVYSPKVSRTALTRENLTRAEDRVRDLESVFSVLLPHVDLEAFLLSVRQGTLDQPVRAAPALPHLSPRQNASIQQDYAYQPATSPGSDVASHEDSEALPSAVDGFDWTEAVNLTALSDGMAALSIKPEGAGYLGATSSVVPLRALLRSDHNNTESSPSLQRHAQQQSSTLLSSVNFTNVTQNTFIDAYFQFYNTQYPFIHESTFRAQLAGANRPKGHSWSILLNTILAIGAWSIGDDESTMDDIFYNEVSRLCMDNSVFESGNLAIVQALLLLSNYTQKRDRPNTGWNYLGLAVRMALSLGLHKEFPKWEITLLQREIRRRVWWGVYIFDSGASITFGRPILLPELGIMDAHEVLNITEDALTPMTTALPVELNDPTQYSGMIAQSQFHISIKGLYNRLIAQPEPSAQELLELEKSIDQWEESIPAYFQINNPRVQADTNFLLSRFKLQWRTMNVRIVLFRPIILRWAAKPWKSDPGSCFEPPEELECRRRCLGNARATINSISDYMTNNISSRLGTWYMLYFLFQAGLIPIIYLMTDPLHADAPSWLDDIRATKTLLTHTSTYNQLAARCLEVVNKLCSPVLDDPEPEVMLQNTDLFDETHAMYLGDQFDLGTMEFWDWSNNVLQGTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1A1</accession>
    <name>A0A3D8T1A1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_01737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1A1"/>
    <dbReference type="OrthoDB" id="2426273at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596:SF2">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G17550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="344"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW92343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="877" mass="100244" checksum="52618E5E62170D95" modified="2019-01-16" version="1">MESLLLPHDPTGPVPKTPYVCEERYDRLPFLTYPVRQGRTATGKAWFDLIDYFRAERVKPTPLPELESFVQTWLLFGLIFEFLDLNKHDEGLGESDRTAEQLSLNESACDDIVGILYGRIVVYEDEKAYVRVNEDTLQYIMETARLRFPKPEDARKARFEHLHQCLIVAHPVLSILPKEFNHSIRFSIAALADLLTETVNFCIIALKVNLQPLGRYWSRGFYSEEIKSSMRASGWCPSDIARAETTFTNLQILHMLRFTSKMLPERDHSSCNNVVCKLYQINMAPGSYVVGHHESDCSCEQLVIDSSILTKILFRGDAFPLLKFSGDVSNLSAEIIESTADTPYIAVSHVWADGLGNPEANALHRCKIQHVEDLIKSIDDSDQSKVQPSLWIDTLCCPAEDGCGKEKAIEKLRLVYKNARHVLVLDSSLTSYDSSQLNAPEILARIFTSGWVRRLWTLQEGALNKSLYFQFADKAVSLESLRMEMDNHQVYNTNIRYRCFRKDIMNQYARLHLFFNSAEYQHLGTPLAVLEQALQYRGVSVATDEPLCIATLLSLHLPTILAVKRKIDRMQKLWELIDTMLNGLPAQLIFSEETKINADGWRWAPASFLAYQDTIKPPQGRPVRWLGEQQRGKITPRGFQVTYPGYRIKMGAYSDGKPSYPWPDLAQIPEAYMDFRDSATGAWYRAGDLGYATIQRRWETDEERIEYNKLKLFPLHDLARSNEAVIVTMKPLGPSTSNPHPVVEGIFATIQPSSDPGIVAVKTKHYLLLTPLHEEGYIYDVVEKVALELRASPLTDEHLRIWEAGNEDEIQESKKAVREAMKVLMKKVIDMDERFRAAVLAHFGNDFLEDIWIKIQDWFRNDINGTPLPNDQVWIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1M2</accession>
    <name>A0A3D8T1M2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_01828</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1M2"/>
    <dbReference type="OrthoDB" id="2532734at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW92434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="84" mass="9119" checksum="B47A1DCF03A2E00B" modified="2019-01-16" version="1">MPAGPDETDNHPTGAATEFVMKNPSSKTEGGSDHPIHDQGPPKGDKVEFRHHEAHPGPAIPKEFNAQEEGTKEERRAKAEALNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T274</accession>
    <name>A0A3D8T274_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_02028</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T274"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017496885" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="43"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW92634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="576" mass="61458" checksum="A4E661BA9E055AB5" modified="2019-01-16" version="1">MVSLVSHLWLLALIPCTVVGAIQPTSTSASPTNTTSSSTAADSPIVTINNYGLLQGNRSQYVNSVYSFKGVPYGGAPTGEYRWKHPPHPSAWNGTRDATQFGPACPQSGVTNYSEDCLYLNVWTPENATLNDVYPSTEGVGVLPNATNSQYPVYVWIYGGRFAGGASSDPLYDGSGLAAKGGVVITMNYRLGALGFLAHPELSANSSSGTSGNYGLVDQQASLHWTIENCAAFGGDPTRITIGGQSAGAASVIDHLNSPLADGLFTQVIAESGVRYPSDPLIGSLAQSYRQLAEAEVQGQAYIEGLNVSSIDEARSLPVEAFLSSGELSDTTYDGTVFQNNSNYMPPPLFRPVIDGYVLPATYQSLLSSGNHSIVPILTGNNKDESGASPNPGYSVANYTAINQLDFGSVDLANEYFSLYPSGNSSTAANNASNAFYRDQSRIGTWLWANEYVAGSQNFSTTGNSTTYSYYWTHAPPGQDAGAYHMSEINYAFNNLYGTDRPWTAQDYAIAETMSSYWANFIATGDPNGPGLASWPANSAASPVTMELGDAFEVMSVANSSNIAFMKEWFSKWTVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T6Z3</accession>
    <name>A0A3D8T6Z3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_00090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T6Z3"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004771">
        <property type="term" value="F:sterol ester esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025:SF3">
        <property type="entry name" value="HORMONE-SENSITIVE LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23025">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="1">
        <location>
            <begin position="74"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW94327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="334" mass="36948" checksum="554F3329CE12E3D9" modified="2019-01-16" version="1">MARVGLFVKVYIFRALQCIFTYLDIYCSTPIPARATFKRKVPSTVGKKSGKIGLLFYTPASYTQTHKTSPHPILINFHGGGFTVGNAHDDARWAQAVTQNTNAVVISVDYRRAPECPFPIGIEDCVAAVLWIWEHASALNLDPSRTAFSGFSAGGNLAYSVAIRLQEELELRKNRDSPSALVTGKLVGLASFYPSTDWTKTREERDASNPNLIPVIPKSLFRAFEESYFFPARSRDSMADPLLSPAFASDEILKAVLPDSMALIMCSGDQLLHEEVQFMERLRGLGKTVEDYTVPDTGHGWDKQPTFRKGNASRDAAYAMAIKSLQASWAVPNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T751</accession>
    <name>A0A3D8T751_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PPPDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_00123</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T751"/>
    <dbReference type="OrthoDB" id="412286at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101005">
        <property type="term" value="F:deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF80">
        <property type="entry name" value="IP06716P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="5">
        <location>
            <begin position="22"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="206"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW94360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="282" mass="31374" checksum="6307B13DB4DDE589" modified="2019-01-16" version="1">MSSKKSSRKVSGHRSTLSLQKTEIVINVYDLLPALSSREPPQPVFKSFADYNADTAAKQPGRLASMLWTIGASLLHTAVVINHKEYAFGGHDKRGMTGVYWTKPRSEPPGGTFKCEILHGFTVSPQAEIDNIIKEASEVFQGTAYNLLSKNCNHFTDYLCQKLTGRPGPSWLNRAASIGVALPCVVPREWIAPPDFDTADGELLEDEEHHSHERSRMLYDTDTSLRRQSHENNNLGDLVEDEEWDSQEERRQGGSGKGKASMKDTSGRIVPASERAPLPRNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7E9</accession>
    <name>A0A3D8T7E9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_00239</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000023">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.40:FF:000083">
        <property type="entry name" value="Sensor histidine kinase/response regulator, putative (AFU_orthologue AFUA_4G00660)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="645"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="1230"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="328"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="411"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="942"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="36"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="331"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="947"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="1286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW94476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1392" mass="152498" checksum="71927726EECCFE3F" modified="2019-01-16" version="1">MAPVAHTIALSHVTGVSDSARARELYKYFQPTAPETTNTETSKSSTLSVSPDVDHQRPELNVQSNVSASKISSPDTALTAFTQLVSWRTGAQRAMISVIDAETQYFIAESTKTVDLLDNTKHGPGDEIWVGCSNVNKSGRLCERTLATTASADQYPSFIVNDLRVDDRFNELPFVTGPPFLKFYAGVPLITKRGIPIGSLFIVDDRVRDGLTKDEIHFMGTMAQTIMKHMEMTREVEEHRRGMKMSRGLASFVEGKAELIEAEADTEEGEGTRIAGQFETDTVFTRSKSKAGSISGATVGSATSVDRKEKEYSNALYKAEEEIQIANDTAENDHSRTEAVTEIRHSLPSQSVSSPLEDAPDKVESPVDEASEESSIKILFSRAANLIREAFEVDGGAVFYDAQKGFSSDFQQKTRGNLRRHESASDADEMESEQANLNEKGELQDAQANDVGPKSPISPRGGMYSRSTISSAKPVEILGFSTAAASSIHGDEYPGPHSFVPVDEKALHTLLKRFPRGKLWTFDTDGAVSSSAEEEIFKSYRKSDPLQRATDASQRKRRRARNELDAKFLLRHFPGVRQLLFVPLWDASRSRWLSGCCVWSTEPTRILSKQSELAFLSAFGNSVMAECSRIDTEIADQKKGDFIGSISHELRSPLHGILASAEFLGEEVTESFSKGLVETIDSCGRTLLDTINHILDFSKINHFEKNWRRNRRGTARSAPRSSSALQIRQADLPMINLFAEVDVSIVCEEVVEGVFAGHVFQNVTAKSFDMVPDSRGKMSDPPKGSLVNRQELAMETVQQPDVAVILDVDIQNYQFTTQPGAFRRVIMNLLGNALKYTARGYVHIKLDATEMDELVTHGSESIARSMVTLTVADTGKGISAEFLRSKLFTPFAQENSLSSGTGLGLSIVRSIVALLEGDIEIDSEIGRGTQIRVTLPLLREMPKTADSGSSNTNKSTNSMSRDTDESVSLLRSRIMGQKVALYGFDSDSEDPITQEMAQLLKTSITNFLANWYGLQVVPYGQKVNFIIANEATPDIISQLSKPTTLKAKAVPILVLCSHSSRFDREFSQSKAKTNCGFVAKPIGPLKLARALLQVLEGAPVTPGFTADPSASLSPGNTDLTNVFEELSIAPEVLDNSRMAADSDNARKAIESPTPSAAEEKHAEFPFPVEINPLLPMMHSMSSENGSLHTLPGPTNPKVASVILSSMENSTKVTQSLSATSIPKVMVPGPRLLLVDDNKINLTLLRTYMRKRKYNVVDEAENGLEAVKKVQEREDLAEPGYDIIFMDISMPVLDGFGATRQIRAIENSRKEKAQQFIDEVVTAGPAKVDPKLPVPALVIALTGLASSRDQSEAFSCGVDLFLTKPVAFKEVGKLLDNWEANRERELKGDPASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7M7</accession>
    <name>A0A3D8T7M7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative G2 cyclin-B1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_00355</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7M7"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20568">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20512">
        <property type="entry name" value="CYCLIN_CLBs_yeast_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="252"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="345"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="349"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="92"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="99"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="112"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW94592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="480" mass="54031" checksum="F09A629F6F340832" modified="2019-01-16" version="1">MPPARAASTRRTVTNENDENGTTTTRLTRSKAAAFGEDVSNVPTKTLQTKKSASTVQQPLRKRAALGDVSNVTKGDAIEGKKAVGKGLVSKASAPTGITKPSRTRSVLTTKDNNKKVVETKRTGSGVVGSKRKTTSSSTVSVKEETPVEEEPSRKKVLTAEKRTKSEDEIKENAITVIEEEQQESAKSAKQLFAEGVEDLDREDLDDPLMVAEYVVEIFEYLRKLEVDTRPNADYMAHQDDLEWKMRGILVDWLIEVHTRFHLLPETLFLAVNIIDRFLSAKVVQLDRLQLVGVTAMFIASKYEEVLSPHVANFRHVADDGFTEEEILSAERYVLQALDYDLSYPNPMNFLRRISKADNYDIQTRTLGKYLMEISLLDHRFMDYLPSHIAAAAMYLARTILERGPWDATLAHYAGYTEKEIDPVFKLMVDYLARPVTHEAFFKKYASKKFLKASILTRQWAKKHALGLGLDVSQPLDNTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7Y6</accession>
    <name>A0A3D8T7Y6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_00419</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7Y6"/>
    <dbReference type="OrthoDB" id="3490330at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW94656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="231" mass="25311" checksum="9B973C87856D28A5" modified="2019-01-16" version="1">MATPRYSVLPRVSTPSETENESLLPTHTSFTTGHLNQTYGITISPTTALRILSSIFCLTSVIILITQGRHFFIAADIFLILMMIQNALQFLKTIFTTTFRVSVEFRGREHDLGSLKKKLSLSIWLDVIWTLAAFLSLAIESAVYFSDRWNYGGGVIGGITVGYIAMLFHAPVVIPGLDKNTVTLTARLNAVKDNRHASPDLKPAVLATPGEEQESGVVNDEASTRSGINLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T835</accession>
    <name>A0A3D8T835_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_00515</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T835"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="406"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="462"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW94752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="521" mass="59049" checksum="844E12BEA021FF7F" modified="2019-01-16" version="1">MEASPRKYKKTRKSTGHAQSRMTQGKSPTYSSWEEITLPDDVVSQAESDFDIIEPEEVQGYATPKEGRDRNKKKSKKIARKVPRTSSPVRHTRIVRSSTRVKSGSNSRGENEVIPSLSDSEDELGDHELALRPPPITVNPKAAIKNLRAILEYLEQIGEADEIRIWMQDHEFLNRGEIFELRSIFAKLDRLLICPGSATTEAVDRNELRINWLGNWAVEILKPVEVLRATSTLKQKTLGLLRVRGEPLIIKATLSGWEDFTSPHPILLNSFRHTRIAMAFAKRWGFKFAAKPGLERQHNVVPGMYQASHVEVQLMMYFCGKVMVEELGLDNTKVELYHKLIKVRPHPEADILLSIDACKECMSFRDKVGEITGIHFEFLTQANVGMLQPEPDEEIIEDTSSVSMAVTKTTHHSKSAENPRKHGRGYLEPEDDFSGNNDFEWTPSKANKSHSTQSPRTPNKYASPKSSATSTPSKASRKSEMAVVIRSKFVRAEKKRDERASVAGETARECFNIERFRHRSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T843</accession>
    <name>A0A3D8T843_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_00479</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NDUFAF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T843"/>
    <dbReference type="OrthoDB" id="270318at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21181">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21181:SF13">
        <property type="entry name" value="NADH DEHYDROGENASE (UBIQUINONE) COMPLEX I, ASSEMBLY FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="308"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW94716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="386" mass="42595" checksum="858986AF3C9C69AB" modified="2019-01-16" version="1">MYYIRGRVSLRPCAKVKSIWRCTYSTAYSTPAPHASQITEADISAARGYCSNLIQKFDSPSHVLQAFIPPSSRDAYLAIRALNIELARIPDVVSNPTVGALRMQFWRDNITRTFASTPPKEPVAILLYNALSTLHSQNPGASTSVMKGWFMKVINTRDQYMDNQPYASMAALETYAENTYSTLMYLTLASLPMNSMAVDHVASHIGKAAGIAAVLRGLPLIAFPPPPNHHSNSAGLGGAMGGTGGRQGAVMLPLDIMADAGVKEEDVLRQGAEAPGLKDAIFTVATRANDHLITAREMLKNLQQGKDAGHDFEHEGEEGHDYVEPKSGSQVQDLERAFGVFMPAVPTRLWLENLEKNDFDIFQPKLRARDWKLPWKAYWAFSRRSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8J0</accession>
    <name>A0A3D8T8J0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_00081</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8J0"/>
    <dbReference type="OrthoDB" id="15189at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF47">
        <property type="entry name" value="ENDOPEPTIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01220)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017623710" description="Peptidase A1 domain-containing protein" evidence="5">
        <location>
            <begin position="20"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="6">
        <location>
            <begin position="89"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="105"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW94318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="465" mass="50030" checksum="4C013CFB974091A4" modified="2019-01-16" version="1">MRFLALLALVCALLSSGDATRPAKPELLVARGIKAKGFQARSEDTNASAYISMTRASKQWSTSHINAYRKRDFGSGIAPTYAIQQAQSWFVNLTVAGKEYALLLDTGSSDTWIASEGFQCLDLHSATPIAEANCAFGPLYSPGKEFKPIANENFNITYGGGEFLTGTFGNTQVTLGGISVTQQIASVTGAGWDGDGISSGMIGFAYPPITFGYNGTDPHNDVPASQIPYNPLFTTLYKSGKISPVFSLAISRPFANSRSCMNGKSYKTQPADGYLALGGLPLVSTTGRWATSPIQYVALGAGYLNGSLPYPQYQFYTITPDSFLYKDSHKTKYKANQWSPLPNPANSSQVQVMLDSGTTLNYIPTEMSYALAALYEPPAVWNDKLGAFSVDCNATPPDFAVKISGVDFSVDKRDMILDDNTGNGTCIAGNSDGMNYPPYILGDVFMKNALVVFDVGAGELRFRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8Q9</accession>
    <name>A0A3D8T8Q9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GDP/GTP exchange factor Sec2 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_00670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8Q9"/>
    <dbReference type="OrthoDB" id="5560525at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070319">
        <property type="term" value="C:Golgi to plasma membrane transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040351">
        <property type="entry name" value="RAB3IL/RAB3IP/Sec2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009449">
        <property type="entry name" value="Sec2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430:SF4">
        <property type="entry name" value="GDP_GTP EXCHANGE FACTOR SEC2 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14430">
        <property type="entry name" value="RABIN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06428">
        <property type="entry name" value="Sec2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144284">
        <property type="entry name" value="Sec2 N-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GDP/GTP exchange factor Sec2 N-terminal" evidence="4">
        <location>
            <begin position="263"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="216"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="174"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="269"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="232"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW94907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="352" mass="39168" checksum="F7ED082EA57F9DDC" modified="2019-01-16" version="1">MTRASNQARMGGGAASPDNPVSHLARSHEELDDSLLSYAAAPTAGFLLSICLSDGPRRPARRGSHTRSSSIDEYDARFQKILLRRTEPSFFNPTYVVSPPWVVSHRWNFRPLSDYIYIHIPSPGAKVPLLLFYEIPPKTNDQMSTVTTIPITMTLAPTACPNCGVGLPHTADMGAEAQRQIEDLQSQIRLLTQKATAAVDKWADYEDEIRQLRQSMLPPVPPEPQSSPLGNRLSSFLSPRKSTQNLRPDSFSNLVPPSTPREADLAAALKREEAARQAAEGKLNEASGELEDLTAQLFQQANEMVANERRARAKLEERVEVLERRDGEKRTRLEKLEKAVGRIERVRGLLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8R6</accession>
    <name>A0A3D8T8R6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein L15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_00594</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8R6"/>
    <dbReference type="OrthoDB" id="361383at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000011">
        <property type="entry name" value="50S ribosomal subunit protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005749">
        <property type="entry name" value="Ribosomal_uL15_bac-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01071">
        <property type="entry name" value="rplO_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12934:SF11">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="5">
        <location>
            <begin position="109"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="47"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW94831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="299" mass="32536" checksum="6EA48B56AB223882" modified="2019-01-16" version="1">MPPRIPALASYCRPVPIASSPLAAFLLPLFQARNASILATLSENPGHYNKRIRRGRGPSSGKGKTSGRGHKGQKQHGKVPARFQGGQTPQEIVHGTRGFENLFSDDMSPVNLDRIQSWIDQGRLDPSKPITLKELCKSRCLHGIKDGVKLLARGKEELKTPINILVSRASTAAIEAIESVGGKVTTRYYTKASIKRLLKGESESSFEPLALTPPTGKESPILAATSPSASPFSYRLPDPTSRKDMEYYRDPAHRGYLSHLVPEGHGPSLFFKTPGASNVRRKAKKVGAGGIARGENKIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9J3</accession>
    <name>A0A3D8T9J3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Carboxypeptidase S</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_00957</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9J3"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05674">
        <property type="entry name" value="M20_yscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000027">
        <property type="entry name" value="N-fatty-acyl-amino acid synthase/hydrolase PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017141">
        <property type="entry name" value="Pept_M20_carboxypep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047177">
        <property type="entry name" value="Pept_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962:SF1">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037217">
        <property type="entry name" value="Carboxypeptidase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00759">
        <property type="entry name" value="ARGE_DAPE_CPG2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="9">
        <location>
            <begin position="293"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="179"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="246"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="550"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW95194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="581" mass="63287" checksum="F5232EADB14D6981" modified="2019-01-16" version="1">MGTINEKGLPTTQTPPSRSRHSKVKTATTVLLGLLSLGYVVTYRSTITESLPGFRKETHPHDLILKSQCQQVDPILPQRTTPELDQILDTISTPGYKNQSIEYLSNAVKIPTVSRDGMGKPGEDKRWEIFYEFHDYLESTFPLVHGALELQKVNTHGLLYTWKGTDSSLKPTLLMAHYDVVPVPEATIPTWTYPPFSGFFDGKQIWGRGSSDDKNQLVAIFEAVELLLKADFTPERTVLISLGFDEESAGTGGAGSLSTVILDKYGKDSIAIIVDEGSGISDIWGHTFASPGVAEKGSVNVLVTVRMPGGHSSVPPPHTSIGVMSELVSLIEASTYQTFLDDKNPYYSQLVCGANHAPDFPKPLKKLLSSSKRSHCGRDVLAEEAAKESLFTKYLMTTSIAVDVIVGGEKSNALPEESTLVVNHRVNIGDSVSHVTSKIASLAEQVATKHNLSLNAYTGKAPFQQSITLAAPHFLEVAPVTPTSVDTLTPYSILSGTTRALYGEDIIVAPGLMTGNTDTRFFWDLTQHIFRFAPGYGGKGEGKGGVGKIHTVDESVSVENHFAAVKWFVLFIRNMDEAKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9M0</accession>
    <name>A0A3D8T9M0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_01013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9M0"/>
    <dbReference type="OrthoDB" id="71672at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06869">
        <property type="entry name" value="PX_UP2_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047168">
        <property type="entry name" value="LEC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024554">
        <property type="entry name" value="LEC1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024555">
        <property type="entry name" value="PX-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47185:SF1">
        <property type="entry name" value="PX DOMAIN-CONTAINING PROTEIN YPR097W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12825">
        <property type="entry name" value="DUF3818"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12828">
        <property type="entry name" value="PXB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="2">
        <location>
            <begin position="191"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="858"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="858"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="882"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="892"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW95250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="924" mass="104915" checksum="AF69B5EE3AAC904B" modified="2019-01-16" version="1">MAVDESVPAAPNQDAITTTNHGQPLSGKQEHYLKRELISQQVKFEITELNSPTALQRFGAPFKSELGEISPLDSELPILRYIFVHHVREFPFLDKAKEKEFWQDKLQVFLQSFANKHISSSEDRLEETKRRKLALKCQKLVELMMVSGVPTASGYEERIRFSELEVVDAGAIEQGVFTTLPEGHYVNGWDVNVAGVRVVSVKRNIRHHKHAEFILRVKKKGDIEHYIGRRYGDFARLHKRLRTELPGKVLPPLPRKNKQSSTASNLISGITGGGNDDDASSMSSVSTAGLPDATSRLSVRDHRRTPSAMSFGRSSPRTSVDGRLSTDGARTPTTPTTPTFGPVTLWRENQRISLRAYLRTLLQTPQIAATRAIQDFLTLTPITPSDEDIEDIAKRKAMDEKRVEEQKQFYEIARKRAAELDVYMEQFRRDIVESNGLTKLFKEIKDKPTIQDLSIQYQKFAEWLRIEVAATIYHLFLAEDNSPELFAQMKKIHSMIPYSLIKNAIRIANPAAVMSSILDIFLAQPFGTRSLMQRIFSLTLNDGIRSFQKSIDALTTKIGEPVFCEKLQKFSDAPEETKNLIRAEAASDDVDLIVAILRSELIEPPLNSEQIGKIFNAYVAWNHVVEHVDEEMKQGAQLFSHLKQLLKLYTRQRDKAMMLSMIEEPVTLHLLRDLFTIFYEPLVRVYKSANVYSSVTDFAVFIDDMILVIDKCRDQDASADPNQTVQAFIDLCQRHEHNFYKFVHEVHTHDNGLFTQLMGWIEGILEFLRNGPKAGKLDINALVAGAVSVNQLDKQKATAEIDSLIAWQEARKKWHQDKTRQKMAAEGSAGVQVETVPGGITFKSSDFGLDQMDLQDMDYEDESESGDEDSEDDELDPIAAERRRRAKKQDHLRRTAGEPVKPEVVEIYNLKESFLAMLRMVLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9V0</accession>
    <name>A0A3D8T9V0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Origin recognition complex subunit Orc5-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_01125</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9V0"/>
    <dbReference type="OrthoDB" id="365981at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041664">
        <property type="entry name" value="AAA_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020796">
        <property type="entry name" value="ORC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047088">
        <property type="entry name" value="ORC5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048866">
        <property type="entry name" value="ORC5_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13191">
        <property type="entry name" value="AAA_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14630">
        <property type="entry name" value="ORC5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21639">
        <property type="entry name" value="ORC5_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Orc1-like AAA ATPase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="ORC5 lid" evidence="10">
        <location>
            <begin position="239"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 5 C-terminal" evidence="9">
        <location>
            <begin position="326"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF14630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW95362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="488" mass="53668" checksum="74893E8AC5E0248C" modified="2019-01-16" version="1">MASLFSLPNEVLLANVAAQFPGRAVQARHLATLLSLRSASCRALVVHGLEATGKSAITRALLEGLCESSSVQHGGSSNGAFQAGLLYAIIDSRECITGRHLLEQVIGAVAKAVGYTGNLRRCENITQLVVELRKLIEWWCSPNPELAQMRSFVLVFDGIDRQREAPPTLLPALARLGELIPCLTVVFIVTLPRPHFLHMNGVPYIHFSIYNKSEAVQILSNTSPTPELPTGHEDTKAFWNRFCSAVWDSLSKHAGRDILSFRTICLRLWPSFVAPVLDGTYGPKDFGRVLVFKRSLFQDERILVPSIVPRTDANLIYKQQGVGTQLPYFSRLVLVASYLSSFNRPVTDHIHFMKGAVSRRRKKGGGTALSRDHNGVAKSRKISRKLLGPQAFVLERMLAIFQTIKQDADDRGRVGGWRRNRPLGLAGDADIQSAIATLASLRLLVKQGGANSADTLDGGSKWRVAVGWDFVRAIARSIGVEVEDYLAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9W3</accession>
    <name>A0A3D8T9W3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_01070</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9W3"/>
    <dbReference type="OrthoDB" id="6077599at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02908">
        <property type="entry name" value="Macro_OAADPr_deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002589">
        <property type="entry name" value="Macro_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106:SF121">
        <property type="entry name" value="ADP-RIBOSE 1''-PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11106">
        <property type="entry name" value="GANGLIOSIDE INDUCED DIFFERENTIATION ASSOCIATED PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01661">
        <property type="entry name" value="Macro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00506">
        <property type="entry name" value="A1pp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51154">
        <property type="entry name" value="MACRO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Macro" evidence="9">
        <location>
            <begin position="87"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="8">
        <location>
            <begin position="297"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="442"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW95307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="595" mass="65637" checksum="DC7EAC39C9CA34F1" modified="2019-01-16" version="1">MESRNAILALSNAIEYLVETYPELVSGHLASHNSSGDLETYQQLDILRSILCVRPPTAKLPAKILDDIVLVLQQEQEHKVLTPSSSIPELSGETQRSVKIKLWKGDITSLAEVTAIVNAANSQMLGCFRPEHKCIDNVIHAAAGPSLRDECGRLMEEQKVEEPVGTAKVTRGYCLPAEHVIHTVGPQLGRGRAPSEKQTEQLRSCYISCLDAAENLPPLEDGRKVLVFCCISTGLFAFPQALASKIAVSTVVDWIQSHPATTITDVIFDVFSDTDYEAYVKVLYTANLLPATPTTLPLPLPNAALQLASTWLKEADTLIISAGAGLSASTGLDYTSTTLFSRHFPAFLQYGFRRLYDLFGPYNWPSPQVKWGYYFTHMQMVRSWPKSPVYASLLNLANTFGEGNVHVRTSNVDGLFVRNGFPSEIVSTPQGQYRILQCVNNCREDATFLSEDFLDAALPFIDPNTQVLTDASKVPLCKYCGGDMFICVRAANWFNQRPFTEGECRWKQFKRQSLAKDEEQRNNVVILELGVGMSTPGVLRWPNEDLAGRSGGNVKLIRVGLDAAGCVDWDFELGVGIQGDIAQVIRGLASSRYHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8TA59</accession>
    <name>A0A3D8TA59_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin cytoskeleton-regulatory complex protein SLA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BP5796_01044</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cell membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Actin patch</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endosome membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SLA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26539at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09532">
        <property type="entry name" value="SAM_SLA1_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11773">
        <property type="entry name" value="SH3_Sla1p_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11774">
        <property type="entry name" value="SH3_Sla1p_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11775">
        <property type="entry name" value="SH3_Sla1p_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000256">
        <property type="entry name" value="Actin cytoskeleton-regulatory complex protein SLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.700">
        <property type="entry name" value="SLA1 homology domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013182">
        <property type="entry name" value="DUF1720"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056996">
        <property type="entry name" value="PH_SLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007131">
        <property type="entry name" value="SHD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035800">
        <property type="entry name" value="Sla1_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035821">
        <property type="entry name" value="Sla1_SH3_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF58">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04470)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08226">
        <property type="entry name" value="DUF1720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24081">
        <property type="entry name" value="PH_SLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03983">
        <property type="entry name" value="SHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="17" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="13" id="KW-0967">Endosome</keyword>
    <keyword evidence="15 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 18" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="11 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 20" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="79"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="22">
        <location>
            <begin position="79"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="21">
        <location>
            <begin position="518"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="21">
        <location>
            <begin position="586"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="21">
        <location>
            <begin position="879"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="644"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="971"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1093"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1198"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="1575"/>
            <end position="1655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="971"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="996"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1013"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1104"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="19">
        <location>
            <begin position="1208"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1257"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="19">
        <location>
            <begin position="1271"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1290"/>
            <end position="1303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1314"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="19">
        <location>
            <begin position="1334"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1359"/>
            <end position="1376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1377"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1444"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1464"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1475"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1575"/>
            <end position="1588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="19">
        <location>
            <begin position="1603"/>
            <end position="1615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="19">
        <location>
            <begin position="1645"/>
            <end position="1655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="RDW95281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1655" mass="179502" checksum="196CEC786100C49C" modified="2019-01-16" version="1">MTISSPSANGAGDNNGSSSCCNKSSSKGVGNSIEYGGLDGEDAADHVLAPGQRNSILDEGELSRYQAERKLVRKIDWRLCTISGILLSLNLLDSGIISSASVTSIFVDLGLGVGNRYSVAILVYTVASVTFQLPATVAVRVLGPRVMFTAITLAFGLITMCTAFINTWQQMVVLRLLLGMSQACVFPGLSYLISSWYTRTEQQLRFAFLLTGEVSIIGFGAFSNFGFNHLDGKAGLAGWRWMFLGQGLVAIVIGFTVYWWIVDFPENSQKSFYWLTPEEQELAEMRISEDRGDVKAESFAWSKCLIHFKDPKLYAFSALFFLLNLVSTSLSYFLPIILQSGMGFSSDQAILLSAPPYFYAVIPVILSSIVGDKYRMRGLVIVFNCICTIVGFSMLGFTNQVTVRYVGTYLATGGYVSNWAAMNAYQANNIVGQWKRATFAAAITACNGLGGIAGAFIVRAQEAPSLPISLSPDSGIAGVLNSYWKRPSRDLICGLHPKLGFQVPTTIDAPLELSLRMGFLGVYRAVYDYVPQGESELAITEGDTLYVLEKSGEDDWWKAKKKASGDEDDEPEGLIPNNYVEEAHPTHSARALYDYTRQTDEELSFTEDAKLEVFDTSDPDWILVGLDGEYGFVPANYIELQDEVEAQESEAPAPTPALPRRPTVVEDPEPESPPAQTPAAAIAGIMSARQPTGMPLPPRQPQYTPDASDEEPPTPTLPARPVSQMQAPEVYSPRSPISPGPLASPPYNRNSQRGMDDHVAAHAPAGFHLYNISEMVSVMGKRKKMPTTLGINNATGEIMIAPEKERDGPEQKWTAEKLTHYSIEGKHVFMELVRPSKSLDLHAGAKDTAQEIVAALGDLAGAVRLGGGLREVYDAVNGQGQKKGQVLYDFMAQGDDEVTVAVGDEVYVLDDTKSEEWWQVRRLKNGKEGVVPSSYIEITGTVQTSSSIGLNAGRSVIEQNRLEEERLAKESLKAARREEERGSEVGPGMKLPERGSSLSVQNGNNSGQQHRNGRSDGGSRTKSKPDPAKVRTWTDRSDTFSVEAQFLALKDGKFNLHKLNGVKIAVPIVKMSLADLEYVEKLTGVSLDEDKPLSAVKRQRQAKQESSSSTPTAGATIERSQKPEYDWFQFFLSCDVAVGLCERYAQAFSRDSMDESVLPDIDAVVLRTLGLREGDIIKVMRFLDKKYNRQGGKRSVSFGGEEVMDGESAGGLFSGPGGTLRNNTRKGRPAPAIQTNDVVDPKAFSQDSPAASKPEGVATPLATAPVPAQKDVPRSGFDDDAWDVKPARSQPAAEAPKPAAPAAQPTPPPPQQPSLTGSMQELSLLSQPLEPAKVQPPPPQPQVTQPPPPQAPQQVPQLTGATPSFFTGIGNQQTGLPQQQSNNSQFQPNMNFAQQQQQANIARQRPAPPQFNQGSGGLLPPLPPSRPLSAPQNQSAFAPPPLQPQMTGIQNSSGYQPQIAPPGQSLNDLTAQRLQQQYTAQQQQMQPQMTGFGGQMMPQSTGFNQFTGQQPNGFQAQPFQPQQTGFQPNFMNGQGQNQQFPAIQPQPTGFTSSFPQQQFPQATGVNSFLPPPLQPQQTGAMQPQQTGMNGFGGQSFGQPPQPTQQQAPAPLVPQQTGPPPPVRFGVTGDTKKLMPQATGRRANLAQATPQNPFGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q534</accession>
    <name>A0A3D8Q534_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein-10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_13155</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000026">
        <property type="protein sequence ID" value="RDW56514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q534"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF11">
        <property type="entry name" value="ISOFLAVONE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G12510)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="47"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW56514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="291" mass="32632" checksum="3D56EF8F4ABFD09D" modified="2019-01-16" version="1">MALNSVLVLGPTGGLGQFLIPELIRRKSSFTRIGAFIDLTRPQSAEKARIMQDSSGFQVVVACLGNHAIKNQPSLIDTALQAGVQHWYPSEFGADLTVGDNWNERYYRDKVLTREHLQKRASENPTFSYTYFLNGRFSEWAPIRHFGIDTKAHTAHIVGSPDMEQSLLGVADVAKYLVCTVLEPPTIQERTFRFLGENVSWTTIFSTLEKIQGVKYTVTFKSVEKARENQRKAIETGDVDEQLAASHQVIQGTGRTLLPGPYDNEKFPEVVPKGLEETWRAMLGDPSKFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q576</accession>
    <name>A0A3D8Q576_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Citrate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_13030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the citrate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000024">
        <property type="protein sequence ID" value="RDW56963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q576"/>
    <dbReference type="OrthoDB" id="435022at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046912">
        <property type="term" value="F:acyltransferase activity, acyl groups converted into alkyl on transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739">
        <property type="entry name" value="CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11739:SF4">
        <property type="entry name" value="CITRATE SYNTHASE, PEROXISOMAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00143">
        <property type="entry name" value="CITRTSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW56963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="391" mass="43142" checksum="768E8CCC72215D93" modified="2019-01-16" version="1">MTSVDGELSIEDSRTSAKYRIPIRNNSILAADLVKIRGPKKGKSLTKNGDGLLLFDNGLQYTAIKKSKISARDAATGMPLYRGYSMEKLTEMGADFEDLFHLMVLGSYPNAEEREWLRAALAKEMMEVPDAVVKVVQAFPRDSPAMSMLLAGLSAYISAYPHGIPALQGSFIYHANPRLADKAAIKTTAAYAVVLGLVSCHRKRIPFKRASASGTFYSNLFTMMGMVGPNDQVDPKILDLFKRGAIYNADNGMTHSTFVLLTAASAFPDPISCLTSAVAAAYGPLHYGAQEAMWNNLQSIGAKENVPAFLEKVKRKERRLFGYGHRAFAVEDPRLKPVMGWLRELNVSEKTQPLFGLANEIDRVASKDEYFRTRGLSANADFYTAFYFNAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q632</accession>
    <name>A0A3D8Q632_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q632"/>
    <dbReference type="OrthoDB" id="5305647at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="168"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW57315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="291" mass="31628" checksum="E5E031A816006EC1" modified="2019-01-16" version="1">MEGSNTQISSYRNGFYSARHFSASKRPQSLSHSLDLGPESPCLAASIHTFIENCPSLDDYSCFPAPQIFPDAEQQNFTAQVVILSELLDPPQTPDTLSSLFNMNNINEEHEGPAQPTEPILPDGTVSLTCTFPECPEQQPFPPKSALRDTKTSTFALISVLTHHATAKTSGTKAASIATPAKSTALNPTPVQYCPRRAHGIRSPTLPQAPSENSEESSESEESAPRPRYENNGESADGGDDVAIVEMPVDGTLSSEDIRMKLRDLRNSRAKLDKAIRTMERALRIMDGASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q668</accession>
    <name>A0A3D8Q668_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12751</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q668"/>
    <dbReference type="OrthoDB" id="5428890at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW57301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="283" mass="32772" checksum="0EE6C7CEA0BA3F55" modified="2019-01-16" version="1">MDPEAVSDQKRAINLAVQLSFMIDCSEKGRHSEDYEIGGFRPVRWEGSERFIDFVKRTFPIELHDQGKVRMAMKEKNALKCWKLKKRAHIKFLPTDNFAEHLLYDPHDGVVRIFRQIAFLRAHLRLSAHLPMNYGFAESLQMGTLPPQLLLETLHSLQGIIFPAVDEKSSRFLENLVRNTQPGFDPDCLLYEGYPRPTPEDFEYYYWGNRLAKLHQVVMNPRPSNRIGQWIQRHASEKNALSVAILSLVLSAFFGFLSVVLGFIQVWLAYQSWKFQANPPPLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q6B6</accession>
    <name>A0A3D8Q6B6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_12845</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q6B6"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="83"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW57395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="25905" checksum="AC8E1F3C9C9B8098" modified="2019-01-16" version="1">MSPAPQPSKWPTSYLYYTLPIYFDSTTISRHEKLKWFAKLNPNGRSPVLIDHAQNDHVVWESTAILLYLVTLYDTENALWPKDVFEQSKVNEWLMLQASGQGPTIGQAFWFGYWHHEVLPSAYKRYVDETKRILNVLDIWLMDRKWLVGGKMSIADVSYYSWYEEAYLVDVDLAKEFPTVHTWMETMGAIPEIVQGSVGREMIKPKKIWERDGYSPAETSSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q7M2</accession>
    <name>A0A3D8Q7M2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_12636</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C56 family. HSP31-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q7M2"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF11">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="6">
        <location>
            <begin position="31"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW57835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="239" mass="25790" checksum="1F82960ECEA4EF84" modified="2019-01-16" version="1">MSPPRRALISITSAQASLFQGKETTGLFISEALHPYNVLTAAGFEVDLASETGTYTADWLSRQPDFLNGNDLAIWNNTNSDFRQKLDHMSKAADLDGSKYGVFYASAGHASLIDYPTATALQKIATQVWANGGIVSSVCHGPAIFANIIDPATNEPLIKGKKITGFTTEAEHSMGIYDELKSWNSEMVEELAARLGATYDRGAGVWDDFHVVDGRLITGQNPQSAASTARAVVEAFEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q7Z3</accession>
    <name>A0A3D8Q7Z3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_12549</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q7Z3"/>
    <dbReference type="OrthoDB" id="3061561at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW57748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="361" mass="41242" checksum="24F15AEBECE49D5A" modified="2019-01-16" version="1">MERDCAAFTGGRFKLIHAFYVSMLALRYRTPQGDRVIWPNQYTWLLQQGLIDRETQASWGVCVEKFRDVSKADSLAKLISLIQVSWFVAQSIMRTAHALPLSQLESMTLSYIPLFAVTYFFWWNKPKDISTPSIVDLPCMHPEQKCIFESMAVSNKFDNEGVDGQVTYWNIWYLTPRVFEKEAEDKALQQAQEKAAQAAAKRAVKSTQENTKPEDTHEEAISTGKGQKPEALPNELPKEIIFSHWDLNLYRSKIWPVACLFGASFGALHLIAWDTTFPTTAELWLWRVAAFVSIFSMVIFMQFEKVVFHWGGPLTIISLVSPVLYFVSHLVMMGLVFAALRAENPAVYDTYSVSAYWAHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q937</accession>
    <name>A0A3D8Q937_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_12283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q937"/>
    <dbReference type="OrthoDB" id="10250130at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019760">
        <property type="term" value="P:glucosinolate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47435:SF4">
        <property type="entry name" value="KELCH REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_5G12780)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW58353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="335" mass="36194" checksum="CAD2483DEBB31FAC" modified="2019-01-16" version="1">MTAISASWRRLASSDKLQRSSHVLSVVNGCAYAFGGELLPRQPRDNHVYKLDVKSSDTPPITEIKDTTMTPSARVGTASATLNGKVYLFSGRGGEAMAPIEEQGAIWELDSSTTTWTLIQPADPSQPFPPARSYHCSTSNNEDKIYIHAGCPESGRLRDLWSFQPSSRTWTLLSEAPGPQRGGTSMAFFNGAIYRMNGFDGKTEQGGSLDVYDLASNTWSTKAYTADGISGPTPRSVSVLLPILVSKGPLLVTMFGERDPSSLGHQGAGKMLGDVWAYDITSELWSKVDAKSNDSVLPHPRGWFDADVVNGSAVVVLGGLGETNDRLTDAWLLQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q9L8</accession>
    <name>A0A3D8Q9L8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Coagulation factor 5 type-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q9L8"/>
    <dbReference type="OrthoDB" id="5186230at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017652700" evidence="1">
        <location>
            <begin position="24"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW58516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="299" mass="32870" checksum="C9A0F94EFBE60751" modified="2019-01-16" version="1">MHLLSKTLKAVLWSSLFLSSVFASGDLKPIFLFKDVLESNYTALTTSGFDTLVIFRVGVLATGDIVYYATGSAAQAVTITAVSNGTYVGGAQLADKIKSYKTGNTTVNRVEVSLVSADTTFVNIENLINTDGEGPTTILYRNFKALKAAWKLDAVNNDDESNYDVPSTLKFAEMLGNIGYKYTSAPYTNLDFWSAIGSSLNETNPGLYDRLYLQCYDGGENNDPGEWQDVLDMKIVPLLWVTNDDKPEYGNTPALAQVKFANWSELYSVAGGGYWNDYDIERMNSSYTLYADALLDVFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QBS4</accession>
    <name>A0A3D8QBS4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7707 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_12024</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QBS4"/>
    <dbReference type="OrthoDB" id="2121879at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056124">
        <property type="entry name" value="DUF7707"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24808">
        <property type="entry name" value="DUF7707"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017698522" description="DUF7707 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7707" evidence="3">
        <location>
            <begin position="62"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW59100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="313" mass="31896" checksum="F9C4292F31EBC3BD" modified="2019-01-16" version="1">MRAVAFLSLLAGVGVLVRADTCGVAPANETVGYIGPNGVEDPSGSKSPDKIHRDQPANSIVRWCKSQQSVCGLSCHSSVLVNDCTRNVDVTTQAGTYCWACTCADGSVPPMVGYMGTISTLVCSRLYSNCLHEAAQSSAPYPFTIGIANCDRLYPCGRNDAGNLLDSYIDDTIWSTVGLLAAVSTTPTTSTTLTTISTTPTATPESNTRISSETSITETSVKLASQTPVSSTSSIGSGSESESSTISTSSSFIASSSSLTITASASSQARTSASATATTSAGSLPSQVAGIGAVAAPRNVALIGAISFLMLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QDV5</accession>
    <name>A0A3D8QDV5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_11611</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QDV5"/>
    <dbReference type="OrthoDB" id="10248446at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02413">
        <property type="entry name" value="KH-II_40S_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.32:FF:000004">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.20:FF:000006">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057258">
        <property type="entry name" value="Ribosomal_uS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018280">
        <property type="entry name" value="Ribosomal_uS3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_uS3_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003219">
        <property type="entry name" value="PRK04191.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00548">
        <property type="entry name" value="RIBOSOMAL_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 7 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="9">
        <location>
            <begin position="26"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="195"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW60005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="261" mass="28418" checksum="EEA5644408C371D3" modified="2019-01-16" version="1">MASGVPGAAISKRRKFVADGVFYAELNEFFQRELAEEGYSGVEVRVTPTVTDIIIRATHTQEVLGEQGRRIRELTSLIQKRFKFPENSVSLYAAKVQNRGLSAVAQCESLRYKLLNGLAVRRACYGVLRFIMESGAKGCEVVVSGKLRAARAKSMKFTDGFMIHSGQPAKDFIDSATRHVLLRQGVLGIKVKIMRGSDPEGKSGPQKSLPDSVTIIEPKEEQSVVQPMSQDYGAKAAQAQAAAEAARSAEQGGEEAPVEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QEJ4</accession>
    <name>A0A3D8QEJ4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Exocyst complex component Sec10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_11763</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QEJ4"/>
    <dbReference type="OrthoDB" id="125856at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000145">
        <property type="term" value="C:exocyst"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006893">
        <property type="term" value="P:Golgi to plasma membrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009976">
        <property type="entry name" value="Sec10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048627">
        <property type="entry name" value="Sec10_HB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048625">
        <property type="entry name" value="Sec10_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100:SF0">
        <property type="entry name" value="EXOCYST COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12100">
        <property type="entry name" value="SEC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07393">
        <property type="entry name" value="Sec10_HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20667">
        <property type="entry name" value="Sec10_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0268">Exocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Exocyst complex component Sec10 N-terminal" evidence="6">
        <location>
            <begin position="60"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Exocyst complex component Sec10-like alpha-helical bundle" evidence="5">
        <location>
            <begin position="199"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW60157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="853" mass="95034" checksum="1B956E374B89624B" modified="2019-01-16" version="1">MAPLNGNSGTGNSIFPTGPSFTIENFSNKDFIVRDFVESLSENAIPQNRRSGPAQQAFDPKPLIRTFENALSQLASLSEELGEKEADLLTSVRRAEVQHDQTLDTLGRKLDQSIDSFEALDITLNNPNAANGSDRNGRQDGGGNIAVQIGEKLEDLDKQRRRAQDATFLIQCWMEVSDSGVLTSLEEIQRQGGGENKVRCAVIARQLMRMSQRLDPNSWASNKKVNGVTNGVVGYKSFNTREIIEKFSETLEKDLLKQFNDSYRRQNFDAMLECAKVLHDFNGGSSVVAVFLNQHQFFIDRNQLITEEVMTDNDTWERLADPDSDPPGVESSLQSLIDEVRVVMQDESFIIKRAFPNYEVVLTKFIQRVFQQSIQQRLEMVLEKAETVSSLAFLRSLHASRSYINTLIEDLKSHGLTEHPEACTAQTALSLDQQLEELFVPYLVGNSYIDRERKSLEELYSSLLFKFTIYHSRKKKVPQGFMASLAQQGTQLLSSAKDAYIDRLDSSELTATQKAMMIRVAGIKEDDNKNEVEVTDEDGILSVPNAKRMLKWMAEGVRRALELGSGSDTPKDVSALLNLLLTSMGQVYVETALDAATDQALVQETMKTEPDLAYLPSLQPAITITNIMSRFINSVLIRLAESNTTVRRSMETQAKQGVESIEKKTNAIMRSTMTVAINWVTKALATQKKLDFRPKDSDLDTVFATLQTPTCATICTFLARTADLSAQAVDGQNLEVFSCELAFSIRDLLFEHFKKFQVNATGGLMVTKDISKYVSTLKDLPLTKEAESSIELLSEIGNLFIIGPEALRERSRFLQVGPADGAGKKLQKADFKAYVLKRDDSSSVGVQSVLTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QHI1</accession>
    <name>A0A3D8QHI1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_11195</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QHI1"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="33"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW61303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="280" mass="31779" checksum="AD8424CE69702645" modified="2019-01-16" version="1">MAPSVVKKGYADISLGQIHYRYALPTTAAQKTPIIFLHKSASSSKSYENLIEYYVSQGHPCYAPDMPGFGGSFDTELDPSPPYSTTWYCSIFEEVFRQLDLFAAGKKVHLCGHHSGSTLALEMGVTYAEYIKSITMIGAGLMNEAERLEMKSHYFAPFNKPVMDGSHLLKTWNYLQQGEVAEDLELMQSELLDHARAWLGRMQIYGAVWNSDRQKNFMQIKCPMLALCARDDVLWQYFHYVNELRPEVRAEEVGGGNFEEVLAWKECAKFMDEMYAEVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QIF0</accession>
    <name>A0A3D8QIF0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Squalene monooxygenase</fullName>
            <ecNumber evidence="16">1.14.14.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BP5796_11409</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>squalene + reduced [NADPH--hemoprotein reductase] + O2 = (S)-2,3-epoxysqualene + oxidized [NADPH--hemoprotein reductase] + H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:25282"/>
            <dbReference type="Rhea" id="RHEA-COMP:11964"/>
            <dbReference type="Rhea" id="RHEA-COMP:11965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15440"/>
            <dbReference type="ChEBI" id="CHEBI:15441"/>
            <dbReference type="ChEBI" id="CHEBI:57618"/>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
            <dbReference type="EC" id="1.14.14.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 16">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="15">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 16">Endoplasmic reticulum membrane</location>
            <topology evidence="3 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Microsome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 16">Belongs to the squalene monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.14.17" evidence="16"/>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QIF0"/>
    <dbReference type="OrthoDB" id="1678617at2759"/>
    <dbReference type="UniPathway" id="UPA00767">
        <property type="reaction ID" value="UER00752"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004506">
        <property type="term" value="F:squalene monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000166">
        <property type="entry name" value="Squalene monooxygenase Erg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013698">
        <property type="entry name" value="Squalene_epoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040125">
        <property type="entry name" value="Squalene_monox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10835:SF0">
        <property type="entry name" value="SQUALENE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08491">
        <property type="entry name" value="SE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 16" id="KW-0274">FAD</keyword>
    <keyword evidence="5 16" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0492">Microsome</keyword>
    <keyword evidence="12 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="437"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="17">
        <location>
            <begin position="20"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Squalene epoxidase" evidence="18">
        <location>
            <begin position="190"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU367121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF08491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RDW61517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="496" mass="54420" checksum="29E489E0BA5959B2" modified="2019-01-16" version="1">MTETVEQHNEKRRRLHHEADVVVVGAGVFGCAVAFAMAKQGRSVLLLERWMKEPDRIVGELLQPGGVYALERLGLAGCLEGIDAVPVKGYDVIYHGNEVVIPYPENAGGIYTGGCTGTEKKGQRPEGRCFHHGRFIAQLRKACAAQPNITIVETEVVSTISSTHNPQILGVETRTTNPSTGEKDHDCFFGQLTIIADGYASKFRKQYHKHTPIVKSKFYALELIDCPMPAPYHGIVVLSDSAPVLLYQIGTHETRALIDIPENLPSAAAKVGGVRNHINNVILPSLPKQVQPCFAKALEDGKIPKSMPNSYLPPTTQMEKGAVMLGDAMNMRHPLTGGGMTVAFNDVLLLSELLSPERVPKLSDTAAVQNAMKEFHWKRKGLSSIINILAMALYSLFAANDRQLKALQKGCFSYFKKGGNCIDGPVGLLAGIIRQPFVLVYHFFSVALLSTWLVITETVDGLTGLWKLPFAVWEAILILYKACVVIFPFIFSEIRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QIH8</accession>
    <name>A0A3D8QIH8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_11528</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QIH8"/>
    <dbReference type="OrthoDB" id="10618788at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW61636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="224" mass="23961" checksum="84D71D675FD72A67" modified="2019-01-16" version="1">MTAWNMEVAQNIHRHVVRAAMKPPMIGPVYDLSTETVPIDEIPSRSTRISQTSRHLPAPRQPSFSSRKTTSNIPNKEPHIGKVKDALAAIDLRQRANSKGPKGGGQEIDGQSHGGFGRIHVEILGDDWQTGAMIVETMIRLNPVADRMSVTAHLRLVVQLSGFLRSDGEKATRKGSSSFTPSPAVVGGLVGAISISRVGATSTALIADSLDARSAMVNIDVGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QIZ5</accession>
    <name>A0A3D8QIZ5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter-58</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_11532</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QIZ5"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF47">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="515"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="129"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="44"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW61640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="553" mass="61889" checksum="BD95072D89380672" modified="2019-01-16" version="1">MQSFIQYRKFSLAVRKQVQEDREKAVFCLSPELHIPESLVRDHRRTSLSSSTTCPAENTAEGLERANSATSARTQYSKRHTVGHFLTGIHARDRTTNEGKGGIVFVVNWEGDDDPLNPRNWGVAYRVWVTLIVASIAFVVGAASSTDTGILTQAAAEFGVSEVVESMTTGLYLAGFGVGAVFAGPFSETFGRNAVYISTMVIFMMFIMAAALAPNIGAQLAFRFLAGAFGATPLTCAGGSISDMWPSLEKTFAFPMFAISAFGGPVLGPVIGSYIMNIGTWRWSEWIILIISAFVLGLVVFFQPETFPPLLLQWKAKHLRDETGDHRFRAEIEIMHISLWMRLKIALTRPLKFALEPIVVLMTLYMTVLYIVLFTFLDGYPHIFQKVYKTSQGLTNVIFTVPWVYKITKECFVKQSFVPEVRLWFAMLGAPAIPISLFWMGWTDYASISIWSPIMASVLFGYGLICIFMTAYMYLIDSYEIYAASALTFVTFTRYVTAGGMTVVGVPFYNNMGPHWTLTILGCISLLMVPIPYVFYKYGHIIRRRSQYAVSWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QL28</accession>
    <name>A0A3D8QL28_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_10825</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QL28"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="42"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW62523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="561" mass="62779" checksum="6DAD3BA7D27F4F68" modified="2019-01-16" version="1">MDPFSMSHHETGWPLRLLHVSSMTSFERQEGNIYRGVTEPEYNCISYTWGRWMSEDRSIVIDGVNWPIPGVKQDCFSVQNFQQAIHRASQGVAFIWLDVACIDQKHRAVKMAEIGRQAAIFNGARNSFIWLHSAPFANLQPAVEGLARLSSMLEEEVRELCGYESPATESSMMSIAGEHDVQLSALCHNTEWLESVLKNLEVLSQEPWFSSLWTLQEMYLRPDGKILARDANTISIQSGSHGPITIANIIMYANTIRDQLVKTNRTQDEMEPSHESSIQRILVLIDQMGLAGSSFNNPCLLYSAAKHRTSFCSTDRIYGIMQVFGYKLGEAAFPLQSFSLLDLQIQLGAAFNKSSPVWAQLFVREKPSQLGKSWLVDEDAAFPDRLQFAETIPKSLCTIDVDSNGTCQFIGKSCMLEDMACFWRRSSAVTAVGESTELPAVQDILLDSVAEVSSISADLRNLSYKNPKQNDLASQLVSHFGDKIRILMVGMLLEGEGETLDARSEAEEQEEEGEVVGILVVKLGNGETKTWRRVGICLWASRMEDVCSTDNLWTEFTGIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QL49</accession>
    <name>A0A3D8QL49_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_10824</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QL49"/>
    <dbReference type="OrthoDB" id="5295335at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="321"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="464"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW62522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="481" mass="54326" checksum="C9E316590A98CAFF" modified="2019-01-16" version="1">MTSQQPLKLPSEQLLQDSSSCDMYQQTAINNALGTLLGYVGAEAATQDLFERLLWPQRFYNGFSLSKLPQVALMMPMGGPLHRAALSTLDILFTNGLLQGHQRGHMLGSPFFANTDAKYTVYESADITRGEKEEARNGLWLRAIGNIPIPLPDTRSNREDEYVEIGRLPLIRSYVRVSHLRIGIPTRKPDRDMIIETDTGPANSRIYIALVCSELVGIITTVVVLIIWRSYFVLLFIAPVCLKLLSAMFTVPREHIQGPKRQYPSRLAEASEKLRVPETRVKKYEIHGLSHGFLLIEGEDDHILQFFRHYGHPIRNRSREFVQFIIIVSFAFIFPIGLLCSLLWMPLGVQYVWLAYQFYATVAVHCYRYAKGHSICTTEEKIAKNLQKSAPPNEEHMKMEAFFGHKDRVLMVCLDTCFHHRYGEGKRCMEKLITGEIYPPAGSESRNNSESILTPDPCSPGPLTPLSLSPLSSGISVNSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLI6</accession>
    <name>A0A3D8QLI6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_10822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLI6"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="34"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW62520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="209" mass="24147" checksum="471FBAB4EBC7E315" modified="2019-01-16" version="1">MPTSSKYTRDTYVTLRTSELLTKLEHVTFSEIEYTYVSHTWGRFRKPGPGAKVQNCRWAVPHNNQFDVESLPEILYSVWKAGKLTTRYLWLDLLCIPQSDTFDRDIELAQVADDEIDRQARIFRNATSCVCWLHDDAISSWKATQKTIRWCAVDWLRKTTIKGLYNLEDLLGLLAAEAETPTELSLSSTPDKTWFHLCGRPKKLVYGLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQY7</accession>
    <name>A0A3D8QQY7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_10707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQY7"/>
    <dbReference type="OrthoDB" id="3562626at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW64205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="271" mass="31191" checksum="37522673DA554E73" modified="2019-01-16" version="1">MTTSALLPAGDPVLFELRAEESTVPARDLAYLKVGIHWVRDINKKVFVRQSEILQIPQPLSNLTAIAAMCLFRPRLENDFEFVDRRPARKVYIAAVTPSPRRSVTRTRISDTVIVAQPPAAQYVQAPARTSVPKIVKAPTPPPPAPTPAPARVELVEVEEAHSPRASRTSVSRRSSRRKSRGGEEREVYIERERERIRGLGRQSPQHPPMEQYRYVEGVQKETRFLEESPYRARSRSITYETNPRHSGRIHERERVVIEDDGRRREFYQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QR21</accession>
    <name>A0A3D8QR21_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Ferrochelatase</fullName>
            <ecNumber evidence="12">4.98.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_10761</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the ferrous insertion into protoporphyrin IX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>heme b + 2 H(+) = protoporphyrin IX + Fe(2+)</text>
            <dbReference type="Rhea" id="RHEA:22584"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:57306"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="4.98.1.1"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Porphyrin-containing compound metabolism; protoheme biosynthesis; protoheme from protoporphyrin-IX: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the ferrochelatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.98.1.1" evidence="12"/>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QR21"/>
    <dbReference type="OrthoDB" id="1323at2759"/>
    <dbReference type="UniPathway" id="UPA00252">
        <property type="reaction ID" value="UER00325"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004325">
        <property type="term" value="F:ferrochelatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006783">
        <property type="term" value="P:heme biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00419">
        <property type="entry name" value="Ferrochelatase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03411">
        <property type="entry name" value="Ferrochelatase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1400:FF:000003">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1400">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00323">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001015">
        <property type="entry name" value="Ferrochelatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019772">
        <property type="entry name" value="Ferrochelatase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033644">
        <property type="entry name" value="Ferrochelatase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033659">
        <property type="entry name" value="Ferrochelatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00109">
        <property type="entry name" value="hemH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11108:SF1">
        <property type="entry name" value="FERROCHELATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00762">
        <property type="entry name" value="Ferrochelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53800">
        <property type="entry name" value="Chelatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00534">
        <property type="entry name" value="FERROCHELATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0408">Iron</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 12" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 12" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW64259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="479" mass="52678" checksum="5BFFB483E90D838A" modified="2019-01-16" version="1">MALRNPLNQLSKRASPSSISKFTSTPTLSSRLRNGDQLRTLATVAPPVTQDSTGSKGPTAIVFMNMGGPSTTAEVGSFLSNLFADADLIPLGRFQSYLGPLIAKRRTPKIEKQYAEIGGGSPIRKWSEYQSAEMCKLLDKMSPETAPHKPYVAFRYANPLTEEMYNKLLADGFGNGKGGRAIAFTQYPQYSCSTTGSSLNELWKWRQRLEGKQTTGAIEWSVIDRWPVHPGLTEALARNIEDQLATYPEERRKDVVLLFSAHSLPMSVVNRGDPYPSEVAATVYAVMQRLNFSQPYRLVWQSQVGPQPWLGAQTSDTVTAYIEKGQKDLILIPVAFTSDHIETLFELDNEVIGESGHKDTIKRAESLNGNPIFIQALADIAKSHMDSGLIIEAEKADRKKVNPSLHPGVWSAESRRCRVVIVTTSHHGQQGEMHEVLAELRIWHSCGADADDVDSAGLTKSTILGIVYLASSDDGTRTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QRI7</accession>
    <name>A0A3D8QRI7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent DNA helicase II subunit 1</fullName>
            <ecNumber evidence="4">3.6.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">ATP-dependent DNA helicase II subunit Ku70</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BP5796_10762</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ku70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QRI7"/>
    <dbReference type="OrthoDB" id="3249161at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043564">
        <property type="term" value="C:Ku70:Ku80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00788">
        <property type="entry name" value="KU70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01458">
        <property type="entry name" value="vWA_ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1600.10:FF:000004">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000071">
        <property type="entry name" value="ATP-dependent DNA helicase II subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.290.10:FF:000001">
        <property type="entry name" value="X-ray repair cross complementing 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1600.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.290.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.970.10">
        <property type="entry name" value="Ku70, bridge and pillars"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006164">
        <property type="entry name" value="DNA_bd_Ku70/Ku80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006165">
        <property type="entry name" value="Ku70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027388">
        <property type="entry name" value="Ku70_bridge/pillars_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047087">
        <property type="entry name" value="KU70_core_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005160">
        <property type="entry name" value="Ku_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005161">
        <property type="entry name" value="Ku_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016194">
        <property type="entry name" value="SPOC-like_C_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00578">
        <property type="entry name" value="ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604">
        <property type="entry name" value="KU AUTOANTIGEN DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12604:SF2">
        <property type="entry name" value="X-RAY REPAIR CROSS-COMPLEMENTING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02735">
        <property type="entry name" value="Ku"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03730">
        <property type="entry name" value="Ku_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03731">
        <property type="entry name" value="Ku_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003033">
        <property type="entry name" value="Ku70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00559">
        <property type="entry name" value="Ku78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100939">
        <property type="entry name" value="SPOC domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="SAP" evidence="21">
        <location>
            <begin position="613"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="564"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00031811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RDW64260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="651" mass="73040" checksum="3562436C1FDAA53D" modified="2019-01-16" version="1">MAENESWRRDSEEDEDDDERDESYYGSQKNAVIFAIEVSPSMLASPPPSDDKKADTDSPAIAALKCAYQLMQQRIISNPKDMMGVLLFGTEKSKFQDEANTSGVISYPHCYLLNDLDVPSAEDVKALRNLLEDDNNSEEVLQPSEEKATMANMLFCANQIFTTRAPNFGSRKLLIITDNDDPHPNDKDASQSAAVRAKDLYDLGVIIELFPISRPDHEFDLIKFYDDIRYRDPEQTDIDALGMTGHQDHKAGGKDGISLLNSLLSDINAKQVAKRALFSNMPFEIGPGFKISVKGYNILQKQAPARSTYIYVDGEQAQIAVGETTKQDENTQKTVEKVEIKKAYKFGNEQVLFTPEEQKQMKDFGPPGIRILGFKPQSMLPNWASMKKATFIFPSEDGYVGSTRVFSALWQKLLKDKKMGIAWFIARSNATPVLVAILPSSEKMDSNTNQQVIPQGLWLYQLPFVDDLRQPPEILKPLVSPDNLIDAMRKIVQQLQLPKAEYDPSKYPNPALQWHYKILQAMALEEEIPSIPEDKTIPKYRQIDKRAGEYALLWMGALELASRSGPTRKREAMDENSGSAAPKKRIKVEPKDETSLFDMSLKTLRGVVEGETLSKHTVAELKALCTAKGLASTGKKADLVDRIEQWVEGQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QTQ8</accession>
    <name>A0A3D8QTQ8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09844</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QTQ8"/>
    <dbReference type="OrthoDB" id="28755at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF1">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW65152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="274" mass="31396" checksum="6451F6279A4F2D3B" modified="2019-01-16" version="1">MDKAFECVVAHYNEDLSWLEPLSSETIVYSKGRPPCMVDCWRDVQLLPNIGREAHTYLHHIVECYEHLAENTLFVQGNVHNSDGKTPPHTDLSAAKMKAEALDNTDRSCGFMAFTSQIIEFKEWGGLPWQDCSSHAWWYYKNGQNMAKAEMTPAEFWMKFFKVPHPRSVYYVSGSVFAVNATKIRSRPRHFYEELRSVFTGLNHINPEYGHFMERFWGSIFLDQPGEANEGSRDDCSKVSGTLGLKQRATSSSTSVIDEREFGERHLQSRLNGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QU70</accession>
    <name>A0A3D8QU70_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_10017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QU70"/>
    <dbReference type="OrthoDB" id="10491319at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW65325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="284" mass="29907" checksum="7B987833E7F7762A" modified="2019-01-16" version="1">MSKAHSHPEQKYEHVHLHGPLKEEAGMSHIGSPTAIKGIPTPAPTYNIDHGPSYEMENVAPRSLSWHASASHLQPQNIPPTLTHPTPTHQPQYHQQEPIPLSFYRPRKELRKSHWYILVALLVLLIIVAAAVYPITQAVSTAHQKSASDGNGVSRTILETRVATVTTTAEKSMTSMVATAAISTTISTVISVSISTSTTISSTISLVSTTLLSTLPASTTSITQTTTAVSTTTTTPTSSSSGAAPLATAAVACFGLVENICANTTSIPTDFGKAGFEGCDSILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUF0</accession>
    <name>A0A3D8QUF0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7726 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_10165</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUF0"/>
    <dbReference type="OrthoDB" id="2592504at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056143">
        <property type="entry name" value="DUF7726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42339">
        <property type="entry name" value="HISTONE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42339:SF1">
        <property type="entry name" value="HISTONE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24852">
        <property type="entry name" value="DUF7726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7726" evidence="2">
        <location>
            <begin position="86"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW65473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="209" mass="23053" checksum="F5860FB056EF9A8A" modified="2019-01-16" version="1">MQPAMRSPLAVADNHISISPPRQYAPILPGDKPLKRKAGEINGVENTPQDTAGKKPTAAPRKKAKPAEEVDLSSIHLDGEEEDAVPVFETCDEVRKKIRAHLKKPGVTQSGFARDCTAASGRNVAPRSINEFLRKKGPSAGNTANIFYAAYVYFEKLRLQAGKPKSKFREEMERIHGPKGVDTTRCNTRYLLGPGERAYEDKYGNVTIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUJ2</accession>
    <name>A0A3D8QUJ2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 11">Cystathionine beta-synthase</fullName>
            <ecNumber evidence="4 11">4.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_10043</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>L-homocysteine + L-serine = L,L-cystathionine + H2O</text>
            <dbReference type="Rhea" id="RHEA:10112"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:58161"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="4.2.1.22"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-homocysteine and L-serine: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.22" evidence="4 11"/>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUJ2"/>
    <dbReference type="OrthoDB" id="728at2759"/>
    <dbReference type="UniPathway" id="UPA00136">
        <property type="reaction ID" value="UER00201"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004122">
        <property type="term" value="F:cystathionine beta-synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019343">
        <property type="term" value="P:cysteine biosynthetic process via cystathionine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000003">
        <property type="entry name" value="Cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000118">
        <property type="entry name" value="Related to CYS4-cystathionine beta-synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005857">
        <property type="entry name" value="Cysta_beta_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01137">
        <property type="entry name" value="cysta_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 10 11" id="KW-0129">CBS domain</keyword>
    <keyword evidence="11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 11" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="13">
        <location>
            <begin position="370"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW65351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="531" mass="56795" checksum="2DF2165149C91CB6" modified="2019-01-16" version="1">MASAMSKPAGPPVLAMSATELIGNTPLVRLNKIPQSLGIEAEVYAKVEFFNAGGSVKDRIALRMIEEAERSGRIKPGDTLIEPTSGNTGIGLALVAAIKGYKTIITLPEKMSPEKVSVLRALGATIIRTPTQAAFDSPESHIGVAKRLQKEIPNSHILDQYANENNPLAHKYGTAEEIWQQTGGKIKAIVAGAGTGGTITGLSNGLKGHNPEIKVIAADPYGSILALPETLNQEHANEAYKVEGIGYDFVPDVLDRESVDKWYKTDDRESFAFARRLIAEEGLLVGGSSGSAMAAMVKGVKDFGLGKGDIVVVVLPDSIRSYLSKFADDDWLAANDLLPPTPSSTLPSSPIFTAQVSKDPYDGATIRSLRLKPVTTVLANSSCSEAVETMREKGFDQLPVLSPTGGKLKGIVTLGNLLSFMSRGRATGKTLVSEVMFDFSTISEVVTDPKDISKLSEAPKTNGIEDTKDGKQQRTPRRKFVEITLDTPLSALSKFFEWNSAAVVTEKGVAKPVAVVTKVDLLGYLVKQTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUR6</accession>
    <name>A0A3D8QUR6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase epsilon subunit C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_10207</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUR6"/>
    <dbReference type="OrthoDB" id="5350595at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019384">
        <property type="entry name" value="FHIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705:SF11">
        <property type="entry name" value="FHIP FAMILY PROTEIN CG3558"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21705">
        <property type="entry name" value="RAI16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10257">
        <property type="entry name" value="RAI16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="722"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="870"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="779"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="807"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="824"/>
            <end position="834"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW65515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="946" mass="105093" checksum="E135CA86E9DFD90D" modified="2019-01-16" version="1">MDFWSRLIAGTSLAPAASKKGSDNPEKRLARFKREYSQLLTTWQRCSNLSKDHEAADDIYCNIQELTGALNDESRRPLPHPCIAFASTKQIYISIGKIATTSYNEYIIREAVALFSTLIESEEESFVQNDAFAKSLMNLLVRITGANSIRLGRETEVEVVELSFNITTKIRLDPDVLPAWFTAQQRDDNGEGRNAHDKFTGKTHKEDFPLFYLLIDYIHEEGRIGDFARTGLLYIIEAASNSVDLEQWIVESDLATMMATGLGALYGQLSRKLVIDHPRDELPPVLAFSDYEHPHSTSEIVSSTSPDFQVHMETFLSHLMFWQDVLNHCKSVEVKATLLEHFQVIFLQQLLYPSLLESSDVDGGSSVAVLFYLRRILESLDHPDMIQLILHYLLALPDTTSATPAASRNSVSAARKRKSLDLATLMATQIADTPSTPALFNLVDLILGSLRSQNQQTISVTLQLVSVILRQHHRYAVSTLLRTSQIKTEGPQRPVGAHELEMEFLLTLATDVGGDEKFDEMYENHIEDCKNILEGHSCSVALIAPKSTGNHAKYPGAHASVPGAPRDIRAHTIQRGDPLLEILQDIFKTFFINSVETNLSLTGTIIDMATCGFMHVEGWLVPDPKRYAYDDEESDMGVEQILADVLELGAELEAQEQVQIRAMKKAQRVPNWSKSEVPEILTILRKLVDQVAIYRKEIPRFDDLLQQRRDTFQAAASVLSTPIPIPYGRRPPRSSFESPTPSPPRPSAFDALAQRIFPDLGTPSRSKSPRGRRSRENSIRSLNSGFGFSTPSSRGSAPPPQFPMGTETPQSMPRSREFSSSPLRESESAQKDRGIPASQAAAFAAIDQSILARKVGLAVAKEEVKPIPFPDLRAIDSGESTAQKEAESNVEPTGDDQTSDGETQIEPTLASVSHILTNVIMLQEFLLELAALIQVRAGLFGEIKFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QXZ6</accession>
    <name>A0A3D8QXZ6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative cystathionine beta-lyase gamma-synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_09442</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the trans-sulfuration enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QXZ6"/>
    <dbReference type="OrthoDB" id="3512640at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003961">
        <property type="term" value="F:O-acetylhomoserine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071269">
        <property type="term" value="P:L-homocysteine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019346">
        <property type="term" value="P:transsulfuration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00614">
        <property type="entry name" value="CGS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000035">
        <property type="entry name" value="O-succinylhomoserine sulfhydrylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000277">
        <property type="entry name" value="Cys/Met-Metab_PyrdxlP-dep_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054542">
        <property type="entry name" value="Cys_met_metab_PP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006235">
        <property type="entry name" value="OAc-hSer/O-AcSer_sulfhydrylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01326">
        <property type="entry name" value="OAH_OAS_sulfhy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797">
        <property type="entry name" value="HOMOCYSTEINE/CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43797:SF2">
        <property type="entry name" value="HOMOCYSTEINE_CYSTEINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01053">
        <property type="entry name" value="Cys_Met_Meta_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001434">
        <property type="entry name" value="CGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00868">
        <property type="entry name" value="CYS_MET_METAB_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 5 6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="5">
        <location>
            <position position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001434-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW66693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="450" mass="48923" checksum="22D4DA3406203D13" modified="2019-01-16" version="1">MPASGSLRGITKEPEFETIQAHGGQDPDPINGARAVPLYQTCSYNFTDAADGASKFAWAKDGYVYTRMGNPTISVFENRMTMLEGGVGAVATASGHAAQFMAITSIMEQGYNFVSTSWLYGGTYNQFRVYLKKFGINVKWVEGQDPKAIAAAIDDKTRAVYIETIGNPKHNVPDIAAIAKVAHDAGIPLICDNTFGMGGYVQKPFSLGADIITHSATKWIGGHGTSMGGIVIDGGKFDWSKSGKFPGFTEEADGYHGMKFWDAYGFKALAAKLRMDAMRDLGPCMSPFNAWLFLMGLETLSLRGERHNENALKFAQWLESNSAVKWVLYPGLESHPDHEYAKKNLRHGFGGVLTFGVDGNIDEVSAVVDNLKLCSHLANVGDAKTLIIHPWRTTHQQLPDEEKIQAGVTPDLIRVSLGLEHIDDIIHDFQQAFEGAGIKAEANGVKVNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QY01</accession>
    <name>A0A3D8QY01_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS general substrate transporter-48</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_09406</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QY01"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF280">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05170)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="319"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="57"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW66657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="474" mass="50133" checksum="380CA30128E8BC26" modified="2019-01-16" version="1">MGSSKALDVNPSKSAANNEGESPCLGSPIVEETKTGTAVRDQDERIGIGPPPDGGFIAWLQVFGSFFLFFNSWGIMNTFGVFQTYYESALPHSSPSAISWIGSLQAFLLRFVGVITGPLYDIGYFRTLIATGTFLVVFGTMMTSLGTHYWHFLLAQGFCVGLGAGCVYMPCVSVIPQYFTTKRGLATGVAATGSSFGGVLYPIIFRNLERSIGFGWAVRIMAFVSLATCSISFSLMRLRHHPSLSPTGRPAISSPSTNVTVTKKQTRSLLEPAAFKEPPYVFFCAAIFLGCISFFIPIFYIQSYAQSGPSSSHSISPHLATYLLAILNASSILGRLGSGVLDRYAGPVNMLTLTSILTGTLSLCWIAIPPSTTGGLVTFAVLYGIFSGGFISLPAVAITSLTTDMSRLGTRMGMNSAIGGFGSLCGSPIAGAILNGSGGWIGLKIFAGVTMLGTGLLMGATKVAKVGWKPWVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYX3</accession>
    <name>A0A3D8QYX3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYX3"/>
    <dbReference type="OrthoDB" id="3642468at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="356"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="400"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW66955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="476" mass="53124" checksum="01AADA5743B3A765" modified="2019-01-16" version="1">MASIDDYFASRQSLWGEFSSSNKSFLTVSEVWHSKDSNSQPEALHRTVKNRELSTWLDNTETSQPMDTTLKDKKCVLRVAWVPHDRKQGLNDVGAGILEHLTRVFHHQLAQLRFRATFAGAASLIEPSNGRRTSFFCNHPNIAVTWSQCTISGLTSVICIADQRKIVILQDLLSCKFIQALANLEPLPALMCSILCCREIDSLINTVKHTVRQVEVRTGHHTFMSRSEPPATGDLLRLSADMSGCISNLAVNTRRLGVLRELNKFIIDKAFDSQKTKNCDKASNSLKELISNIKTIQKHSEMQKLDVEFFASRAQIQRDALVHLIAEHELLANQELAKDTRRLAVLAQKDSAGIKALTIVATLFIPPTFVSSLFSMPLFDWGSAGTENHTGGTETWKNRLLLYLTVTGPLMLVTFSVWGLLILVWRLKQKKEVKQLRLKARCSTSQGSEVISLVSKRMSGISTSGDSEALLGQFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QZ00</accession>
    <name>A0A3D8QZ00_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_09657</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QZ00"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW66908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="297" mass="32556" checksum="EE9AF2C8F7A234C1" modified="2019-01-16" version="1">MPQLVWLVTGCTSGLGEELVYAILARGDRVIATGRNAVIRLSHLKDSGAAVLDIDVTASQAVLNIKIEEALAVYGRIDVLVPNAGYSEIGFVEELRQEKWQDQLQTNFFGVTNITRAILPHFRKRKVGHIAIISSVLAWSGALAAGPYAVSKHAIDGYGKTLQQEVAQFGIRTVIFNIGYIRTKLTSTPKVSVPEDDEYRSIFERFLEASATIPGNEPGDPKKCAERIVDVMKGEGMASGKPMPSQVPLGSDVLATVKETCEAMLKTCEEWKDLIKSTDFEGPKQGFWAENTVRTSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R2P4</accession>
    <name>A0A3D8R2P4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_08980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R2P4"/>
    <dbReference type="OrthoDB" id="3034343at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="23"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW68323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="643" mass="72109" checksum="BB3879A1B288615A" modified="2019-01-16" version="1">MESASSIVPIPSARPYRSHKLRACDYCRKRKARCSVEVLGQACLLCRANGRQCEYSDARITPARAGSRPSDLDSHPQSPSAGQSLKRSHAVLEDNITDSPLYTQHVARKQALRRDGIDDDNGITTQSAHIVGPAITSDAHVLEQYMSPNSPEGNEPTQNPYRVYSADPHKPVLYRRVPRRRAGLEVAKEPGVKQQVVLEQVLAPNARRLLHLYLDKVHPAFPVIDENQLLDTRKNDASGPSAALICQIYAITMTYWNQTSFSKVHPHPDSRFAWNLAVKALQDDFLAPTLSTLQTVLVDLTGRPTYSITGNVINIGRAVTFSYSLGLNRDPSQWNISQYEKNLRVRIWWGILIHDSWGSLAHGTPSCINSTQYDVPPPTLDMLKSTVNSSRAHEKSLEGFIALCSLTEILGRVLPLVYDLKGNTQKETLKTIRRVETDLDEWEDSLPEYLIRNSQEEPAVSGSKFHYMQAVAQSDASNTSEALKYRQFECRKSAQTIVNFVRSLQSSHLGEFWLPYGAYYLTSTTTLLLRFAVETTEDAVAESCVSSVKMLTQRLRHAREHDDWDLADDCLSQCEGIIARMTHNGRSSDQTSNLPRPIFNGLEIDAPGDWLDATMPAFYGPMDGSSQMRDVWGMFDYEEPLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R2U1</accession>
    <name>A0A3D8R2U1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha hydrolase-18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R2U1"/>
    <dbReference type="OrthoDB" id="58297at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47562:SF2">
        <property type="entry name" value="CARBOXYMETHYLENEBUTENOLIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="35"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW68286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="271" mass="29476" checksum="B900EE47C1280DEF" modified="2019-01-16" version="1">MLIKEDHRDVPTKADGKDGSMRIFLFHPTIPGYPNARFPGIVLFSEIYQVTGPVARFARQIAGQGYIVAAPSSYHEFTGPEPLAYDVKGTDDGNEWKVKKTVKAYDEDATLSIDVLLSLPTCTGRIGTTGMCLGGHLAYRCALDPRVSAAVTYFATDLHSGTLGAGGDDSLARAGDIKGELALIHGTLDNHVPPEGRDLIRKTLREKGVVFSWYEPAGAQHAFIRDELSKGRYDPAITKVCFEILLELFGRTLKLDLGAHDGGVQKIENIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R375</accession>
    <name>A0A3D8R375_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleolar protein 58</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_09018</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for pre-18S rRNA processing. May bind microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R375"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000003">
        <property type="entry name" value="Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000001">
        <property type="entry name" value="Probable Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nop" evidence="10">
        <location>
            <begin position="285"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="420"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="439"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="451"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="483"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="498"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="508"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="561"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="582"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW68361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="616" mass="66534" checksum="11EF0DD894C3656C" modified="2019-01-16" version="1">MGLFVLTETSAGFALFKATDKKMLKKDGMSADVETAEGINGLLKLKKFEKFDSAATALEEVASLVEGKVSPMLASLLDTLKDEKKASLAVADPKLGQAINKLPGLNLTPISDSSTSDVFRAIRDHLPSLIPGLLPENISTMSLGLSHSLSRHKLKFSPDKVDTMIVQAIALLDDLDKELNTYAMRVKEWYGWHFPEMGKIVNDNLAYAKVILTMGMRTSASTTDLAEVLPEEIEAAVKAAAEVSMGTEITDEDLTNINLLAEQVVGFTEYRQQLSSYLTARMNAIAPNLTELVGELVGARLIAHAGSLMNLAKSPASTIQILGAEKALFRALKTKHDTPKYGLIYHASLVGQATGKNKGKMARMLAAKAAIGLRTDALSSWSAQGEGKGDDVDDEERVALGVASRAKLERALRGLEGKPLLPRGVAVGPNGQPVAAPKWEVKEARKYNNDADGLAGDEPAAAAPASEKKSKKEKKDKKKPLIEEVEADSDSDEEMADADAGSKSSSNKKAEKEAKKAEKKEKKSKKSSKEDEAPVDPDEEKYGALAAAAGISVAKYKRKAERGDIKVGDDGKPIVIHKKKEKNVSNDEEVKSKKRKADDEEKEDKSEKKKKKKSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R3H5</accession>
    <name>A0A3D8R3H5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R3H5"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF102">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW68603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="38888" checksum="59F2521E0412B2D4" modified="2019-01-16" version="1">MASHQQDIPTVVDTPEVEDSPSIDTNSEPARDDDSAIDGMSNASSTASLQSSLYASVEENGRTYHRYKEGKYPLPNDAKEQERLEIQHELFRATLRGRLYLAPIESPKEVLDIATGTGVWAVEFANDHPESNVLGTDLSAIQPLYIPPNLRFEIDDAEDEWLFSNQFDYIHGRALVSCFTDPSVVLKSAFNALAPGGYLELQDGIFPMEYIGEPPVESNLYKWNQLLIEGSTKSGRPWTNVRHYKRWMQEIGFEEVVEKEFYWPTSQWPKGSYLKGVSNWWQKDFLQGLDGISMRIFTGMLGWSVEKVKEFTDEVRKDVVNKEIHAYLPIRVVYGRKPGNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7T3</accession>
    <name>A0A3D8R7T3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter-5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_08519</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7T3"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF26">
        <property type="entry name" value="OS04G0435100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW70122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="522" mass="56658" checksum="BCCB1D8A210FB6E9" modified="2019-01-16" version="1">MPDWDPKYFQKDEEKLKELGYKQQLLRNLTPLHSFGISFGVMSVPGSVSALFGYSYATGGPGVMTISWIIVSFFSCFVAMTMAEIVSALPTCGGPYFWAATLAPPKYAALAAWMTAWLNLMGLVASNTTAAYGISQLIATAASIKTPDYHVTNGQNIGVCAALLVSWALVNTVGRPFLRHILYLAIALNICGTVVAAIALLVKAPTHQPASFVFTTFIDRTGPSPDDGWAMRASPAYVACIGSYMGLGTFYGYDASAHLAEETLRADWMAPLGIIAAVGLSALLGFLLIVSLLFSVQDLNILDILQDRNPVLEIFIDSFGENGGLALFSLSIMSIWFCGLFLTMANSRLIWAFSRDRGVPYFFSKINERYMAPVRAVTLTTILSFLLCFASLGSTVAYTAVTSIASTGILTSYCIPFVLKVIYHENFSFRKGPFQLGHFSRLVSLVAVLWILFSCIVLCLPTSTPVTIQTLNYSPIAFGVIAVSSIGFWLLRAMRVFVGPVKNWNAADISNLMEISTPSKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8N2</accession>
    <name>A0A3D8R8N2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Flavin-containing amine oxidasedehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_08601</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8N2"/>
    <dbReference type="OrthoDB" id="2019015at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050464">
        <property type="entry name" value="Zeta_carotene_desat/Oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923:SF20">
        <property type="entry name" value="FLAVIN-CONTAINING AMINE OXIDASEDEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42923">
        <property type="entry name" value="PROTOPORPHYRINOGEN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW70204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="568" mass="65179" checksum="DF9271B5B8738BED" modified="2019-01-16" version="1">MAATNGHNGERERDQRKHVVIIGAGAAGMSCASTLSQHPDKFKVTMIERMAVCGGQATSISIDKSRFGTDWMNDGVQGGSPHTFNFFKTYGHVPKEVKLQVSFGKGTDGFWTNCFPSKLIEQFSGDIKKFGRVLNIIRWTMPILGIVPVRVMLRMFFFSKDFGDKMVYPLIALFLGTGNQTANVSCAILERLFNDPNMKLWDYDPETLLPNLPTMVTFPNLHNFYEDFRKDLEKKGVEIRLQTDVTEILERSDDGIVLKTKPFDPDANDRRGVHTGSESRPEYFDELVMCVLADDALKLLGKTATFRERWVLGGAKFFDDITVTHSDTAYFQKHYETEFDPKLCAEPKSKAQEEQIAFSKGEMRGEGDEPSGFRPMYYTKTYQDDPKKIEMSFDVTNYQHQFRMDHQAETAPIAYDHHVFQSIFLDKTNRQHWTMEEIDKSKIIDKKWWHQLGHRWQHYARVVPGMLFINGRKKTWFAGSWTLVVRLPPVLSNSYVQVCGRGRLANLQELTCGSNEQNMHELACVSGIAAAYRLGAEYVKFDDFAEDFFSKYLLVSHGVIYRRKQKHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R976</accession>
    <name>A0A3D8R976_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">NB-ARC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_08811</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R976"/>
    <dbReference type="OrthoDB" id="427518at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056681">
        <property type="entry name" value="DUF7779"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25000">
        <property type="entry name" value="DUF7779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="10">
        <location>
            <begin position="49"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="9">
        <location>
            <begin position="458"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7779" evidence="11">
        <location>
            <begin position="705"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="377"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="393"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="411"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW70414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1028" mass="115203" checksum="6FA595C10DB06DEF" modified="2019-01-16" version="1">MPFSTRRFIFKSNSRRQRPESDEAGEGERQCGMFCIVNKSPTDPQVVDVVALHGLNGHYQRTWTAKTSDGTKVNWLKDLLPAQIPNARVLSFGYDSAVQFSKSVSGISDFAEQLLNELLAQRETVEEKQRPLIFVCHSLGGLVFKQALIRAHERGRYSDLLAYIHGVAFFGTPHRGSAVASWGNIFANIAKTASLGTSTNAMLTRDLKERSGVLSQISTSFVERGGKLDIFSFYETDKFPGMSCRIVEKDSAVLGWTNETTIPISGDHTSICRFSSVTEAERGRWQVVQSNLGSMARTALNKSIITEAAIGNTETSILATVGQDAPSQMPSTSAPDTRRFPVVTTLRSKEHLAKAIEEASKMERLLPDGFEEAHAVAPYGSGAPANNTSNSIQHNNSGSGHQNSGSGQQNIGTNTGSGQQYIGTNNIVTHSPDHKGDFSTASPPVCNFVNRPALYSLMREQLHDTLSEQQVHSKILVVFGLGGAGKSQLTLKYAETHRDDYTGVFWIEAGQKESIEKGYRQLYSQLFENKESTDLAADIAIARVKSWFDGRDGRWLFVLDSADTIDHDNEDSYIDLRNYIPTASSVDVIITTRSSEARAITKLRPVEVAELEIAEAVELLRNSNLMHAPEQVLVDIVKELGYLALAISLAGAYISATPRLKNNIHGYLPEYHERRKILLSRKPTKLIDQYGESVLTTWESSFTAICKVSPAASQLLGLLAYLDPDDIPELFFQMDEKQDWQSEIFPGGALDKYKFEDVFRTLRTYSLVHYQDAKEAYYLHRLVHAWAYDRLEEKERDAFCITSLNLLATISSGSTSTPEFRIRVVPHIMMSYRLSIRVYEASSNRRGNIIDYFGELGGFLRAEGHWAAELQFRKFCCRENDQLLGQEHPDTLTSMAALASTYQNQGRWKEAEELFVQVTETRKRVLGQEHPDTLTTNLASTFWNQGRWKEAEELEVQVMETRTRVLGQEHPDTLISMNNLAWTWEGQGRDEEALHLMLSCLELSARKFGVDHPYTIARSRTYNTWKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDC3</accession>
    <name>A0A3D8RDC3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_08004</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDC3"/>
    <dbReference type="OrthoDB" id="10291890at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW71970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="371" mass="41824" checksum="64B74546BFB020DF" modified="2019-01-16" version="1">MAHKFSPPDLSSNSFSDCLVILCVGRNARYALERRRTLQYFRSITPENALFYPSRKFSIDQLSPSIEEIVAEEPARASNVCPWKAPLEVTYRYRLSIPNPDADSRTSSEACWYEAYKKKNERDLVGFRQMFLEPSDNVHSGHESAVVTKSLDTRSRISSSSGSLTAVNSSSSLFSNTDNPLRYFLETPDAAPAGSNGTIATSSTLHFEETCKEEDKKWLLTSILGKIDTAGRYDEFLYYPELVEFIELVCLLVAGHHSTTGGRKALCQQTIDLLRMKFRCSQIPITPDFSDASVSFVGRLLSQCPLEELVHMESTVRDMLAKLPDYKEKPTKEDAPLEYVTVNSSLGRMRMSKNYPVDWDYGGLATKYCAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDD1</accession>
    <name>A0A3D8RDD1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">5'-3' exoribonuclease</fullName>
            <ecNumber evidence="15">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BP5796_08093</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Possesses 5'-&gt;3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.</text>
    </comment>
    <comment type="function">
        <text evidence="13">Possesses 5'-&gt;3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote the termination of transcription by RNA polymerase II. Essential for vegetative cell growth and chromosome segregation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Interacts with RAI1; the interaction is direct, stabilizes RAT1 protein structure and may stimulate its exoribonuclease activity. The interaction also stimulates RAI1 pyrophosphohydrolase activity, probably by recruiting it to mRNA substrates.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="15"/>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDD1"/>
    <dbReference type="OrthoDB" id="28245at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006353">
        <property type="term" value="P:DNA-templated transcription termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.1050:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000003">
        <property type="entry name" value="5'-3' exoribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000005">
        <property type="entry name" value="5'-3' exoribonuclease 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017151">
        <property type="entry name" value="Xrn2/3/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF41">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037239">
        <property type="entry name" value="Exonuclease_Xrn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 15" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 15" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 15" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="9" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0806">Transcription termination</keyword>
    <keyword evidence="16" id="KW-0862">Zinc</keyword>
    <keyword evidence="16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="18">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="404"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="507"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="844"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="404"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="428"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="445"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="546"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="873"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="883"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="924"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00046137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00046943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR037239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RDW72059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1004" mass="112030" checksum="4B58B1B0BB0D62EA" modified="2019-01-16" version="1">MGVPALFRWLSQKYPKIVSPVVEEQPREIDGQIIPVDTRGPNPNNEEFDNLYLDMNGIVHPCSHPEDRPPPKDEEEMMLEIFKYTERVVNMVRPRKLLMIAVDGVAPRAKMNQQRSRRFRAAQEAKEKEADKAELLKMLKSQGGRIEEEAPKRAFDSNSITPGTPFMDILAASLRYWCAYKLNTDPAWAKMKVIISDSTIPGEGEHKIMSFIRSQRSSPEHDPNTRHVIYGLDADLIMLGLGTHEPHFRVLREDVFFQDSKPRTCHLCGQAGHEARECTGEAKVKDGQFDEKDSAHPLKPFIWLHVSVLREYLAAELYVPDQPFKFDLERAIDDWVFMCFFVGNDFLPHLPSLEIRENGIDTLIAIWRDNMPYMGGYLTKDGHVDLERAQFILDGLAKQEDQIFKRRRQTEERRDANAKRRKLQQENGRGGRGGRGGGRGGGFQDSPTHGRQNGKSSASDAPAMLPLFAPNNITKEARNLTHDMIVNRKSVYEANMANKSAAAALKSQLQGNGASNDASEPNGATESPQSALGKRKAELIEDEDSSTPGRTTPAPSTPQTPGDEMPPDTVRLWDEGYADRYYEQKFHVDPRDLEFRHKVGRAYVEGLAWVLLYYFQGCPSWDWYYPYHYAPFAADFVNLKDMQISFSKGSIFRPFEQLMGVLPAASRHSIPEMFHPLMTEPDSEIIDFYPEEFELDLNGKKFAWQGVALLPFIDSKRLLDAMAKIYPSLPADVAARNSVGKDILLVAEAHHSLYDDIATNFYSKKQGQPKFKLNARLSEGLMGVVEKDENVLPHSSLEFALDADAMPKLDDDRSITVFYEMPTSNHIHKSMLLRGVKFPSPALTQSDIEATKGRASKSGRNHGGAPLQGNGRGRNSFNYASPNNNGGHQGGNSNYSNNQHGNSYGSQGPYNGHQYSAPPPPPGYGGGGGYGRGGSNYGNGHNGNQYSQPQPYPPPPGMAGFARGPPPPPPPGYGGSHGAFPAPPPSYNQERRGNDSNRGQYGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDY0</accession>
    <name>A0A3D8RDY0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methylated-DNA--protein-cysteine methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.63</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">6-O-methylguanine-DNA methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">O-6-methylguanine-DNA-alkyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_08108</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-O-methyl-thymidine in DNA + L-cysteinyl-[protein] = a thymidine in DNA + S-methyl-L-cysteinyl-[protein]</text>
            <dbReference type="Rhea" id="RHEA:53428"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:13555"/>
            <dbReference type="Rhea" id="RHEA-COMP:13556"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:137386"/>
            <dbReference type="ChEBI" id="CHEBI:137387"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 6-O-methyl-2'-deoxyguanosine in DNA + L-cysteinyl-[protein] = S-methyl-L-cysteinyl-[protein] + a 2'-deoxyguanosine in DNA</text>
            <dbReference type="Rhea" id="RHEA:24000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:10132"/>
            <dbReference type="Rhea" id="RHEA-COMP:11367"/>
            <dbReference type="Rhea" id="RHEA-COMP:11368"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:82612"/>
            <dbReference type="ChEBI" id="CHEBI:85445"/>
            <dbReference type="ChEBI" id="CHEBI:85448"/>
            <dbReference type="EC" id="2.1.1.63"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MGMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.63" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDY0"/>
    <dbReference type="OrthoDB" id="1907495at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003908">
        <property type="term" value="F:methylated-DNA-[protein]-cysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001497">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00589">
        <property type="entry name" value="ogt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10815">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10815:SF13">
        <property type="entry name" value="METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00374">
        <property type="entry name" value="MGMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding" evidence="13">
        <location>
            <begin position="204"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="113"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="175"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW72074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="309" mass="34108" checksum="4E65581B38FA34C1" modified="2019-01-16" version="1">MAPVSASIQQLQNDWKEMFQKKLPVAATTKSDTQTKWPVHVDHCFARIILDTKIGIDVPWMEKLKSPAYKNMTEQQLRDCIQLGEEILSGNADIVDLNRQSLDIRGKKKGIVAGENQSGKMEANATKRKRKESEEGEETDSHPLPKQKQRQLGHTKSPFFPPAKATTHSASPELPSSPTPPPSPSEEQSDDHTLDLIKNSTKTPFQKRVLSLLCQIPRGHYTTYGSMSKFLNSSPRAVGNALRNNPFAPMVPCHRVLATGGGIGGFHGSWGRGGKEGVHDQDKRRLLREEGVKFDGKGRVVGGVWGGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJ75</accession>
    <name>A0A3D8RJ75_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Chromatin modification-related protein EAF6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_07458</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the EAF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJ75"/>
    <dbReference type="OrthoDB" id="440324at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015418">
        <property type="entry name" value="Eaf6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13476">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN MEAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09340">
        <property type="entry name" value="NuA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="125"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU368022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW74016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="184" mass="19647" checksum="272996BA44B2589C" modified="2019-01-16" version="1">MAENVAPASAGPNGDVPGQPFYDKSRQALKKLLHQKRLLETALQAQEDAIFKKETEYLEETPSGNIITGFENYTKSSAAAPGGGRRKGQVTEANRVFSRSSISYNVDSAFDSATSTPMAAMAPTPVSASFQKGESASNHATPTSASSSNRVASGAGKKNKKAEEEDEDDKRDMKKIRMTGAARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPD9</accession>
    <name>A0A3D8RPD9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_06641</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPD9"/>
    <dbReference type="OrthoDB" id="10336383at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW75820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="116" mass="13047" checksum="0DD3D4AC5BD5B43B" modified="2019-01-16" version="1">MSHQNYAERPAIIHSRNSSASSRSSANSYTQQFDRSSMGTGNHSSTGSLTTECYRVPNDRQKEIEATTRVNHYGKSVTVINHRQGGYEVAAPRTAMATQSNYYSPRRDDRQTRRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPF2</accession>
    <name>A0A3D8RPF2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Choline monooxygenase, chloroplastic</fullName>
            <ecNumber evidence="5">1.14.15.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_06750</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the first step of the osmoprotectant glycine betaine synthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>choline + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = betaine aldehyde hydrate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:17769"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="ChEBI" id="CHEBI:15354"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:15870"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="EC" id="1.14.15.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (monooxygenase route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the choline monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.7" evidence="5"/>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPF2"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="UniPathway" id="UPA00529">
        <property type="reaction ID" value="UER00430"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019133">
        <property type="term" value="F:choline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019285">
        <property type="term" value="P:glycine betaine biosynthetic process from choline"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00680">
        <property type="entry name" value="RHO_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015879">
        <property type="entry name" value="Ring_hydroxy_dOase_asu_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756:SF5">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00848">
        <property type="entry name" value="Ring_hydroxyl_A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aromatic-ring-hydroxylating dioxygenase alpha subunit C-terminal" evidence="8">
        <location>
            <begin position="103"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Aromatic-ring-hydroxylating dioxygenase alpha subunit C-terminal" evidence="8">
        <location>
            <begin position="170"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00014931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW75929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="323" mass="37252" checksum="F12DF51B299D94DB" modified="2019-01-16" version="1">MKDSGSTTVLACKFHGWTYLPTGALHTAREYMELPNFNASEHSLFKIHTHVTAQGFIFVNFDASPSPSVPFSFQFGDDFDPTPEAATGKEIGDKFALFPPIHEWVYDHTWLSESAGTNYNWKTFADGFQECYHCATGHPTTLPKDFCLNEYYLRQGHGSSRHFLPSADSRIKESYITWLYPIGAIIFSEDLLFIARFDARGALDTRYQSETYRRKRMAKDTDEHKHWMDKDIEYWRFVEREDVELAVNAQKGFANGILAKGRLHPLQEHAVKWYQDKLRASLVEHKQLENDTGGALDYSLPNAEKEWEDKDPLCKLMGSELEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPI3</accession>
    <name>A0A3D8RPI3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_06615</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3509968at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000055">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000066">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002145">
        <property type="entry name" value="ABC transporter (MsbA subfamily)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF404">
        <property type="entry name" value="ABC MULTIDRUG TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="264"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="493"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="905"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="945"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1017"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1044"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1128"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="277"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="618"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="906"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1223"/>
            <end position="1455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW75794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1460" mass="161057" checksum="7774A9BA98D5B040" modified="2019-01-16" version="1">MAVAPQCPPGSDRHFGPRVDVECRSFDFTLAFEDCIFGILPSALFLLAVLPRARQLLRASVKVDSIRLLTIKLITLGILFVIQLVFTVFRTANFALATPFSLSSAVLNVIATLAAVFLSYLEDQRSVNPSSLLVLYLSAESILSLPRLRSLWMLSYAGVCTILWTAAVVFNVSALILESVRKTRFLKNNEKNATLEEICGFWGRSFFIWILPLFKHGYTTILTLDNMGQIDQELQGKPAHERLEAVWKADTSHKHAMLKSTLRAYLWPFLSAVFPRLFLTGFTFSQPFLITATVTYFEMPDTPETKYYGQALVGAFVLAYLGMAVSTAIYWRQAFRFVTLARAGLISMVYNQTIQVKALDLRDSAAITLMSTDVQRIVDSLRIVHELWASVLDIVIAIYLLERQLFAACVVPVVIALVSIFAISRISGTSNLSQKAWIERVQKRISATSNMLGDMKAVKMLGLAPTLSTIVEGLRNIEIKTSHHFRKLLMWQIFWSNMPIDLTPFATFAIFTIIAAVGHSGSLLTAQAFTSLSLISILTSPLVTFTQAVPSMAQCLGCFERIDAYCRITGFAKVAAERSILEQDSDSEIGTHENLDTSTSNSVQMEVLKADSRSNPLLSFKAASFSWSKDTSNVLHEINFELQPNTIKMIVGPVGSGKSTLLESMLGETTLTGGRISHSLSHVAYCSQTPWITNNTIRHNITGFGQFDETWYNHVIWATSLEHDLQQIPLGDSFMAGSNGVNLSGGQRQRVSLARAVYSRKSIVLLDDIASGLDTNTVQQIAARLFGPDGHFRKSGRAVILATHTLSLLKYADIVTVLENGRIVDEAAPGKNLLAEEIIKDSPDSERGASSNGSDKVSIEVEAVTKPAVITSIDEAETEVPDFARRDGTWSVYKYYCRMAKWRNIILFAVLAFALAFASNFPSLWIQWWSNANAKAPNSHLGMYLGVYGCLSLLSLITILIACWILFINIIENTALGLHTDLLRSALRAPFSFYRATDTGTTTNRFSQDMDLIDMRLPILALNTGEAIGSCVVKLVILSIMAKYLAATIPFVGFAVFVVQTCYLRTSRQVRLLDIEAKAPLFTHFMETVGGIVTIRAFGWEGDFQDRAFFLLNESQKPVYMLYCIQQWLTLVLDLIVGAVAVILVAITTSMKHSFSAGSVGVALNMVLTFNSTLTRLVNMWTLLEMSIGAVSRIQSFVKDTPSEERVEVLDTAPCGWPSRGKIDFMDVTAGSSPESPAILSSISLSIEAGEKIAICGPSGSGKTSLILALLQMIDVQQGSIVIDGIDLATMQCNDVRAALNVIPQEPFFMPGSVRFNLDSRGITSDAEYFQEALEKVGLWEKITAKGGIEADLEAADWSVGQRQLLALARALLNKSMVLILDEATSSVDHETEAIMQAVIDKDFAQQTVIAVVHRFAFIHRFDRVGLLKSGVLIECDTPSRLLSKDSEFKKLYDAMGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPL8</accession>
    <name>A0A3D8RPL8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-glucuronidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_06717</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPL8"/>
    <dbReference type="OrthoDB" id="3491192at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052974">
        <property type="entry name" value="GH79_Enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031728">
        <property type="entry name" value="GlcAase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183">
        <property type="entry name" value="BETA-GLUCURONIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36183:SF2">
        <property type="entry name" value="BETA-GLUCURONIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16862">
        <property type="entry name" value="Glyco_hydro_79C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-glucuronidase C-terminal" evidence="3">
        <location>
            <begin position="528"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW75896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="643" mass="70460" checksum="BACE4D7558D5AD29" modified="2019-01-16" version="1">MASLTPVSVGRQLPSPEPPQFRLTTPRMDPFETAASTETTSECSNSINSHKKTRIRVREITDEKLQTPLSIKGKWRARAFFHQCVRHWVITGSAILSVILLALTIALALHFTIGRRKDRDEPTSSGYSVTVSSIAPTKNDFPPIGQAFVSFAIEFAFFPDFAGNKSAPNTFSDNLLNNIGNLTGTKPYIRVGGDSQDFAIFNSSLPVAIQGVYNYSHTHNYPTEVTMGPSFFESYSTWPNTKFIHGFNMGLATTPAGWASLLQTIPLACSALGSGNLLWWEYGNEPDLYPTSPARVLRTGPWNYSIYLDQWKNGTAAIEAGIKTSCPNLTSTEEYGYVGPSYAYRGLDPSATFASGLNENGTIKQITMHHYMGDTRDHGISLQNKLMNHTSVAHTLGSQLRKEAIDLSNATLVNPLSPTQQIPMVLNEANSLTSNTFGPKDMLDVFGNALWTLDYMLYCATLGFSRVHMQLGTDFRYSSWQPVTTANMTKGTLPPYYGNMAVAAMLGNVSAAAPQIVNLALEHDLEAAYAAYTNGTLVRVALINLKQWNVSMSGNDNSTARPNRTYMLDLGLKNGREVKVQRLLAAGSDAKRGISWDGWSYEIDLDEGRPVRLPNVTVGEVLKARNGSVEVAVPDSSAVILTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPR7</accession>
    <name>A0A3D8RPR7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_06874</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPR7"/>
    <dbReference type="OrthoDB" id="60955at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061700">
        <property type="term" value="C:GATOR2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037590">
        <property type="entry name" value="WDR24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="147"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="243"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="14"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="413"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="599"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="667"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="745"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="823"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="883"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1113"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1168"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="429"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="473"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="605"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="695"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="715"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="835"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1113"/>
            <end position="1130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW76053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1188" mass="131261" checksum="161C1F2D98FB8929" modified="2019-01-16" version="1">MNKGNTIMRKLLRQPANVNGHADSSINDSPQLRPSASQNTVYSAGSPITCLDRSPDGSHAVFAGPKVFKTLKIDGSTISEDIDLRALITDYAANHDTSAATSDRLTIKSVAWSHGSEDSKILTACANGRVTLYDLNKLGEGLEVARIHEHTRQVHKLAINPFRAHVLLSASQDGTVKSFDIRNRIQGRSGLVLKTWQNFKCNADAVRDVKWSPIDSMEFACSTDAGVIQKWDLRKGTAPVLKIPAHTKACFSIAWHPHGEHLISGGLDQKCYVWDFSKKGERNQKYKYSFDTPAPVSTVSWRPACWSATAQGRRAAQVTVSYDDTNSNKTPNPSVHIWDLARPGIPFKEIDQWDTAPTGLLWSTRDLLWSVDRDGHFTQTDVAFVPKVIDRRTLSDLSFSSNGDLLMVLEERQTPRRPRPTISPADVPSSFSISPNGPQLSVSRSDSEDDVIGGFLGPKVRKSFGRHGARPSHASTSTPNSSMNGNTGKTENKVMSLDEAVMVTGPYKPQQVMAIGQAPSTAKRSLYEYLTNRYLSRLEKSQSTPYSVQTPEILLASTTEYFARTAEHVGHYRLAQTWRILGYTIGLLLTRRAEYHRQSRLAPQKPERQQENKKVKVVKDKGEETPRKLPRSLSPLESPIYPAGRSIIAEETESTSNVATPLVRPVRDTFSRETSEATTTPLASEENFENDVLKLPPPSFANSPSPIPVPGAIQSPRTSPSEEPSNVEGYDFYGIDSISPAENLTAVPQRKQPLRLDYPEPSAASRRMQVGRHDSGESFAMFSTSGDSQPHFMSSSESDFARSIEKENGKSLREAVSTWENSFTSSSAGHRPSVDSLNDPQYSSFDGHNASASSNGLTHALPQKRPSPPTLIVQQASFREALDDTKADGDASDAQDDLNHLSDDPNIIESDYYSWPNDPKFVDLPIDPTVLVQRTIQFETQTGVLNASAIMLLLGPLLPPKTLDAVQSAAILRQYHQRLQNFQLFTEATLLRNLCVPAYPTVWEDCQKDINVGYFCTDCQKPLENDPLIPGSMWRCPRCRGSIDGCAVCRHREPEESLTSGEKSILLWWSCPGCGHGGHLTCMQAWHDAPSDGCCPLEGCLHPCLPGPWREQREAEKRSQQAKEMDRLVRENSAVRGKPRSVSVRRDAREVNQSKAVEGVRVALALSQGSGGMERRRSVKVVAPGEKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPS7</accession>
    <name>A0A3D8RPS7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_06779</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPS7"/>
    <dbReference type="OrthoDB" id="1099at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000319">
        <property type="term" value="F:sulfite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.150">
        <property type="entry name" value="Voltage-dependent anion channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004695">
        <property type="entry name" value="SLAC1/Mae1/Ssu1/TehA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051629">
        <property type="entry name" value="Sulfite_efflux_TDT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038665">
        <property type="entry name" value="Voltage-dep_anion_channel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31686:SF3">
        <property type="entry name" value="ACID TRANSPORT PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G09410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03595">
        <property type="entry name" value="SLAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW75958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="413" mass="44986" checksum="F89CA16B2B3D1E34" modified="2019-01-16" version="1">MSGSIKSPESQEALEAQPVAGAHLQQRRRRPLLAAIETFPPTYFAICMNAGIISILLHQLPYNFSGQLVLSTIAYLTDVVLFVIFSFFMAARLLFFRRSALHSIGGDIEQLCFTACWPIAWLTISAGTGLVVSQASWAGYRWTVVAYAFWWVGAAWVFVTGLIVYMTLFRKNLLSLHNATPALMLPAVGVATAASTGGVMINYSSGITATLQVPVIIVGYLLLGQGLFLSLVLYTIFLLRLFTEGFVAAEKMPSLILLLGPVGQGATALLVLSSAADTAGAFAHYHEGTFLQANAASALAVASTMLSLLLFGFGVFLLCISLLAIAETMWKRELKWTMTMWSTIFPMGMWTMNTAMLVYATEMNSPAWRVLTAALLLVLVIDFLICAGYTIYGVVYGDLLIPKDARKPEKDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPY8</accession>
    <name>A0A3D8RPY8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Maintenance of telomere capping protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_06940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPY8"/>
    <dbReference type="OrthoDB" id="5594977at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018814">
        <property type="entry name" value="DUF5427"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28265:SF1">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10310">
        <property type="entry name" value="DUF5427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="429"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW76119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="530" mass="56808" checksum="B94BCB280785828C" modified="2019-01-16" version="1">MATKKSKAAPTDEELNKLLEGIGEDDAPKPTTSKGAPKTTKTATTQSEEDMLAELENLGAQPVSRPHTPQIKPPVTHASRASPGKRTTATPPPTSTRTSEDKPAAPRKSADSTRSLHTSFTPSATSSELQENEKKAPVAEPAEPAATGGGWWGSVFATASAAVKTAEAAVKEIQQNEEAKRWAEQVKGNVGALRGLGGELRSRALPTFTNILHTLAPPISSHERLQIHITHDFLGYPSLDPLIYSTFSRVMAQVEGGDLMVIQRGQEATVRRNSDAGYTGGSAGWSDGPWWRQTNEHRDLGAVKGLVEGTKLVRVSAEAYSNEYFTANGGLELAAQRATENLSESNPVRSSDIFLAVQAISHEAPEDLFQGSPKEKTQSDVVEEKPKPDELISFAIYLRDPVHSIIFYTITQSIPAKWIAWLDAPSPLTPASPTSPSQQKSGFFGREGEDGMNPNLPQEIAEIIESGGVDPREWVAEWVEEILSLGTGVVAQRYVARRMGVGEGGIGRGKARMEEVLGDGGGEAARAGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVF7</accession>
    <name>A0A3D8RVF7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_05820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW77968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVF7"/>
    <dbReference type="OrthoDB" id="10261782at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038921">
        <property type="entry name" value="YOR389W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35204:SF1">
        <property type="entry name" value="ENTEROTOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35204">
        <property type="entry name" value="YALI0A21131P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017772335" evidence="1">
        <location>
            <begin position="20"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW77968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="436" mass="49586" checksum="3F8E77B7906CAD33" modified="2019-01-16" version="1">MFVRHIIVTFASAVSLTHGSQPQKLLSLSNDNDRYGPSIDCAKKNANFIFNAVHSSMRQWGNSLHHNGLSLYPAMIPQGTLLYHGAPDAKTPPSFEWLAFEIEHAEMFAISWEEVGQGRPSRQSILYSNVEKSTANAAHTQQEWIFEPGYLQIYQANRPLRVLYIDGSSAAKSPFGTLDSQDLIILDKPRSHREELERAKDLCTLGAEWGIEGFIRMEAGFELIKCDFSDGFDYLSHNKRPENDSLKGTEDVFFVEYMRDVASRYHSIGARRVVLDYSSMTSAFFYPANLSSEDSGDYDLSLPRVMHTEHDQLLRIRSDLKEAVFRQTSVHESVDWQGVVDMIVLRFADRLTLLEADLSYLRMTTEIDNLLNMYIDFSETRPNITESIETCSLHYLRPVEPSTVQDHLIYAAIKTATDKICTTLFQAREHLLSCTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RW24</accession>
    <name>A0A3D8RW24_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative DNA-directed DNA polymerase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_05992</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RW24"/>
    <dbReference type="OrthoDB" id="2320933at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.20:FF:000005">
        <property type="entry name" value="DNA-directed DNA polymerase theta, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057220">
        <property type="entry name" value="DUF7898"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046931">
        <property type="entry name" value="HTH_61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048960">
        <property type="entry name" value="POLQ-like_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF6">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25453">
        <property type="entry name" value="DUF7898"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20470">
        <property type="entry name" value="HTH_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21099">
        <property type="entry name" value="POLQ_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="148"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="404"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW78140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="932" mass="102671" checksum="3C456746E7E52CDB" modified="2019-01-16" version="1">MASRKESSVGHKTTVNGPLAVRNNTTAIVSAASHKRPFSELLQNDRLVPTNEVGTSRRHFQRPSLIETRPQILKASEICDCENNCRLRNPATDYSQRKRLQLTPTPASDPLLHLSHPCYNLLPGLVQNFANLGICSIYPWQSKCLRGRGLLSGKRNLVYSAPTGGGKSLVADLLMLKTIIENPEKKAILVLPYVALVQEKTRWLRRAVEGIQKKQSDVVNNQQHALWRKRGDENSVRVVGFFGGSRSMANWADMDIAVCTIEKANSLINTAIDDCTVSNLGVVVIDELHMIDDDHRGYLLELLGTKLLSLEQKVQIIGMSATLQNPEILAKWLSNALYYESKYRPVPVEEHLVFDNTVYAAASSSSFYKTATQLQLAQSKTAAQAVPVPLRTIKSSEHSELKNPLINAVVALANETARAGYGALVFCSSRTGCETDALLISQVLPRGEEVSQDLMRERRDLMHELRSSSTGLDPVLEKTIPYGVGFHHAGLTTEERDIVATAYDNGIIKVIVATCSLAAGINLPARRVILHGARMGADLVGPAMLRQMRGRAGRKGKDEIGETYLCCQKSDLEAVAILMEAEIPVIESCLLPGKRGLKRALLEVIATRLATSAGSVDDYIKKTLLYQSIHGDELSDMVKSTLTELSADGLITNAGGSEFEATTLGLAVTASSLGPEDGLFVNRELRKALRAFVMDGDLHVLYTFTPVQVTLSKVDWQVFRKEMDNLDESSLRVMSFVGVKPSLVNKMAQGGTMKESTLAEEEVARIYKRFYTALQLRDLCNEMPIHAVARKYGLPRGSVQNLAQTCHGFAAGMIKFCERMGWAALGAVLDHFSDRLKAGAKADLLALAEITYVKSRTARIFWENGFKNVGAVAAADIKELLPVLLMAQPKKPRLDAAEEEKYHQKLLLKAEIISKSANRVWDRIMQAEVEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S231</accession>
    <name>A0A3D8S231_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_05033</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S231"/>
    <dbReference type="OrthoDB" id="3525185at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DBAG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW80335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="424" mass="47056" checksum="0BAC62A80565D9A6" modified="2019-01-16" version="1">MQAFLTDYCINSRNRTVSLGYLNGLEALIERAGPTSSVAEACRTIGLAHLGQKLSNPVFMQKANKMYFELLPSFRLTISNKATSTTVHSLMTAVLLGLYEIITSTGTKPGAHIAHARGVSAILTSKSSPFNLLCEGKLFQLASPLPLDQLETLESKNATTSSLQRSERFSILCTPTDNTSWPTLDAIFVKMHPLVRRAEVALADKSTLLEDLQRFKQEAEQIRKDYSTWTMNIPKEWQPTVVGIIPNTHFATRLEPGYWPGPVMKYYDLYVSSIMNSYRKARLLLLDVIVNCDKAISRLQKNVIADPTIFAEIQELTFDITASIPYHLADNLQEFDQSLSSDGTMKAIVPGRSVGGLLLMHTLYMVATLSIADPALKEYFRDCLAWIGKNMGIGQATMLSETTHLDLQGFITEAHVLIWAGMLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2C1</accession>
    <name>A0A3D8S2C1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_05127</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2C1"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW80429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="70" mass="7708" checksum="2C6E1F36EF70F0E9" modified="2019-01-16" version="1">MALIETVRTKQTFGSSHTRADMAPEPVPGLASAGRREGRVHAQVKDVISDQDVGDAIIYTRIWVCRAELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2E2</accession>
    <name>A0A3D8S2E2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Adenosine deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_05143</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2E2"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000034">
        <property type="term" value="F:adenine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006146">
        <property type="term" value="P:adenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043103">
        <property type="term" value="P:hypoxanthine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114">
        <property type="entry name" value="ADENINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114:SF7">
        <property type="entry name" value="ADENOSINE DEAMINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="4">
        <location>
            <begin position="30"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW80445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="384" mass="43576" checksum="55223354F0752866" modified="2019-01-16" version="1">MDKTPYTTILEWQSAVASSRKTDAFIAEIPKVELHIHIEGSMTSTLRWHLGQRNHLPLRNFSQTETYTTLPALQSAYHLNNPLQPRSTTGSTQMSAFFEAYYGAMDVLRTELDFYDLAMDYFTRFAGLAGCYAEVFFDPQAHTRRGIGWDVFMPGLERARVDAERELAVKCNYIMCFLRDLPPADAEAHYEAALPYRSMIVGIGLDSNEYGRPPLLFQDVFTRARKDGFQITAHCDVTQHNCHEHIRQVACELGGSGAGRIDHGLDIADAPALLEIARAKRILLTICPWAYVRHVRAEKLFADIRKLVDLGLRVCIASDSPAYMEEQWLVQNLLLIRLHCGFTNEEILELQRNAILGCWADEQVKQQLMDDLHAFGMRFGVVTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2V9</accession>
    <name>A0A3D8S2V9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphotransferase</fullName>
            <ecNumber evidence="6">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_05198</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="6"/>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2V9"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24000">
        <property type="entry name" value="ASKHA_NBD_HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF29">
        <property type="entry name" value="PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="7">
        <location>
            <begin position="5"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="8">
        <location>
            <begin position="229"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW80500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="504" mass="54906" checksum="D3D05E5C0125EA30" modified="2019-01-16" version="1">MATSLSEFLQPLSIDTAKVHRLAQALCETFRSLARESENQFLSTPISESVLRPDGDESGRYLAIDIGGTNLRVGFIELLYPSDHALNGIPNGDSSRVRRLLEKAWPIGEQLKNEKAEDLFAWIGHCIAEVVRDASTAWNGELAPELPMGVTFSFPMIQHTLSDATLMSMGKGFAITSNLDLGRQLLQGYESHRGTLPRIRIAAIANDTVATLVSFCFQAQNQPGCKAAMGLIGGTGSNATIPLFPRLLHASKRLNSDETKIVVNTEWSINGAAPPLQALGLITPWDKILDLQGEVPGFQPFEYMTAGRYLGELGRLILLDYLTSIRSIPPARIPKRLQTRHGLTTAFLGNIRPDAPQILQQLDAELPGPESWTWTTELAHMLYSIAKAIQVRAAGLTAAAVLGLLGCAEELDINHLQRNLKPEITELMVGYTGGCIVHFQDYLHDCQDFLDEISRDGAVGVKLHPCHDGGIMGAGILAGRVSRTESIASGRVGWPALHGLRRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S335</accession>
    <name>A0A3D8S335_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_05411</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S335"/>
    <dbReference type="OrthoDB" id="2163411at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00174">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861">
        <property type="entry name" value="GLYCOPROTEIN 38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16861:SF4">
        <property type="entry name" value="SH3 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G13610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017725145" description="SH3 domain-containing protein" evidence="3">
        <location>
            <begin position="41"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="272"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="425"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW80713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="572" mass="59255" checksum="F3B12C465650E2E9" modified="2019-01-16" version="1">MGARDGRIGPLDPSNIRKQGRINLRTVLLSLLAVAPTAMAASSSCISLSSSTACSAFNRSQVSVDSTLVGLFPFLAYVSDTATFDSGLTSYVNTAYVQSKYQNLLGCTNINLSNVTNLLTTAESLPACAETCASFAESEAMIVADSALCSSSSSNSNTQSSQIRADFTNCALPAGSLSGGNSCIVGSANEPDNCGFGNSTIGLCQYCGSGGENSTDTCCYNSGAATRCAGVVLPTITGYMTFSTSIPSSTATGVASSTGVAGASANGISKGAIAGIVIGSVLGLAFIVGLIFLMIICLRRRRGSQQGSVFNQPTPARKPQPGMAYNPVGTTRTPEGYEVLPGGRIARMSALEGHSGDSPPRGEMGAGAAVGAAAGYAAGRRGRSHEPSSSDEFGDSPVSVKGGVLRPPPQTQRRHGSLSSNSVLGAGDDPSSPRSGSGDNMSSPQGVASQQSEQLNSFRDYYSQDEIHPGDKVATLWAYQPRAGDEFALERGDMIKVVGIWDDGWATGIMIDERAEEWDAKHNMLRDSGVSNTSGRREDSPDAPVNGEIKAFPLVCVCGPSHWRKTIEGEET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3B9</accession>
    <name>A0A3D8S3B9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aflatoxin biosynthesis ketoreductase nor-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_05289</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3B9"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF26">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY OXIDOREDUCTASE (JCVI)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW80591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="24298" checksum="83179537D2E4C313" modified="2019-01-16" version="1">MNSLVQRPNTTVIGTVRGDAESFDTSKLVLAKGSLVIIKTLSSTSETDATTLITSLELSHNITYIDIIIANAGIAASFDSALKTLISELRVDFEVNTLGPIKLFQAAYPLLQKSQRGPKFIYISSSTGSIELKLEYPILAYGVSKAAANFFVRTLHFEHEDLVAVALHPGWVKTGNGQAFADAVGVAEPPMSIEASVDGVLKQVDAATRETTSGKFVSYDGKIFPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3P2</accession>
    <name>A0A3D8S3P2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_05409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3P2"/>
    <dbReference type="OrthoDB" id="2130169at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="1">
        <location>
            <begin position="206"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW80711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="558" mass="60539" checksum="E1D2DB1D9B29E9B9" modified="2019-01-16" version="1">MPGSLVLPSSAFLALLPPELRNLVYDYALDWPQLSTLVVHMRQDEHSKISSAQQCPLPTLPASCSSSLAILETPTILLLNRQITQEALRVLRQKPLVLDSALPSAEMCITEYIGSTTLQHVRLMVLDIALSQSNATAWLRMVEALLDLLFAANSLTRLVLKATYNPTVPPAGWTFNDINSHGHAMSLLCRDNSLDEAIIVSDLHTGATGYIGGDILHELDNAHPDYEYTALVRDSERGALVAAAFPKIKLIYGTLDDVEVIEKAASEADIVVHTADASDNAGAAKAIAKGILAGHSKTSPGFWLHTSGTGILCWRDSEAKTYGEAPSSKPYDDLEAVEELTHLPDTAFHRDIDKLVLEANAAHPDVIKTAIVCPPTIYGPGRGPGNQQSRQVNTLVKVMFETGHAPRIGKGQSEWNNVHVQDLSVLFRLLVEKAVAMSRSDGSIYSEIFGQKGYYLAENGHHVWGEISQKAGKIACEKGYIQTADVAALDLEDADKRAGFEAVSWGLNSMGSARRAGEYLGWTPKQRSLEEILPEMVVAEAKAFGLEKGYREKAAGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S490</accession>
    <name>A0A3D8S490_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_05582</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S490"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017494665" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="55"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW80884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="588" mass="62106" checksum="947213DE974A712B" modified="2019-01-16" version="1">MKLFSAVATVVAVAVTGSEGSPTYSSASPASVSGSAASALPTVDLGYALHKATVNATGSYYNFSNIPFAEPPLGSLRFKAPIPPQTRNRTVNDGQQTRICPQSNPAWELIAAQFLAGTNVSTLAAEEAASSSSLNLSSIPTPGPRENEDCLLLDVIVPEAIYSSAYGKASRSNSTCDGSAGAPVLVWIYGGGYTSGSKGGNNPAGLIAASQTRGSNGIVYVALNYRLGMFGWLGGPIFQEGGTANVGLYDQRLALRWVQSNIHLFGGDPKRVTVMGESAGGGSIEHQITAYGGSQGKAPFQQAILQSAAFQPYPDPSQLDGIFNSTLSYASLVANTSITTLSQLRALPSSALQLINKVVVGVSPYGLFTYGPSVDGVFVPALPGQLFLSGQYDKSLSLMVGHNSDEPTFFTSPFINNETAFNNFISTSVPEASAAVIAYIENVLYPPVFDGSQPYTSNYGRAKRVIDDSSFSCNARYLAAAFSNQTWDYYFTVPPGFHAEDLAYTFFNGDTSTLDDGLAVQVPVAKTLQSYITMFTKYGNPNGNGTPYFPVYGANSSSLVLDITNAGKVQKDSVATAYCDWWQKGLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAB1</accession>
    <name>A0A3D8SAB1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal protein bL31m N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_04803</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAB1"/>
    <dbReference type="OrthoDB" id="5587740at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.130.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034600">
        <property type="entry name" value="Ribosomal_bL31m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048874">
        <property type="entry name" value="Ribosomal_bL31m_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L36, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28174:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL31M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21492">
        <property type="entry name" value="bL31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein bL31m N-terminal" evidence="2">
        <location>
            <begin position="33"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW83312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="145" mass="16321" checksum="AA67D7BB083ED5FC" modified="2019-01-16" version="1">MSQLPSLTLRRAHIPQISRCTQQQTRHASLLRRPLRPYTFTQLITLSDGSTYTQRTTSPAPVFRSTKDTRNHPMWQPSLDSLRNVEQDEAGRLRAFRERFGRGWDAEEPVEEGAEAPEEESLMDLISGGNWDGGAAAAKEGKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAC2</accession>
    <name>A0A3D8SAC2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative heat shock protein 90 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_04798</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAC2"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.790:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000001">
        <property type="entry name" value="Heat shock protein HSP 90-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="9">
        <location>
            <begin position="26"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="214"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="674"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="215"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="674"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="99"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="119"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="375"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW83307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="702" mass="79777" checksum="E5FD9C7256105125" modified="2019-01-16" version="1">MPGETFEFQAEISQLLSLIINTVYSNKEIFLRELVSNCSDALDKIRYEALSDSSKLETGKDLRIDIIPDKENKTLTIRDTGIGMTKADLVNNLGTIARSGTKQFMEALTAGADISMIGQFGVGFYSAYLVADRVTVVSKNNDDEQYIWESSAGGTFTLTQDTEGEPLGRGTKIILHLKEEQLDYLNEAKIKEVIKKHSEFISYPIYLHVLKETETEVPDEEAEETKEEEGDEKKAKIEEVDDEEEEKKEKKTKKIKESKIEEEELNKQKPIWTRNPSDITPEEYGAFYKSLSNDWEDHLAVKHFSVEGQLEFRAILFVPKRAPFDLFETKKTKNNIKLYVRRVFITDDATDLIPEWLSFVKGVVDSEDLPLNLSRETLQQNKIMKVIKKNIVKKVLELFSEIAEDKENFDKFYTAFSKNIKLGIHEDSQNRAALSKLLRFSSTKSGDDVTSLQDYVTRMPEHQKNMYYITGESLKAVQKSPFLDALKEKNFEVLFLVDPIDEYAMTQLKEFEGKKLVDITKDFELEETEEEKKEREIEEKEFEGLAKALKNVLGDKVEKVVVSHKLVGAPCAIRTGQFGWSANMERIMKAQALRDTSMSSYMSSKKTFEISPKSPIIKELKKKVESDGENDRTVKSITQLLFETSLLVSGFTIEEPAGFAERIHKLVSLGLNVDEEPEAAEEAAAEEATGDAPAESAMEEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAD4</accession>
    <name>A0A3D8SAD4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peroxisomal trans-2-enoyl-CoA reductase</fullName>
            <ecNumber evidence="13">1.3.1.38</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BP5796_04565</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Participates in chain elongation of fatty acids. Catalyzes the reduction of trans-2-enoyl-CoAs of varying chain lengths from 6:1 to 16:1, having maximum activity with 10:1 CoA. Has no 2,4-dienoyl-CoA reductase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>(2E)-decenoyl-CoA + NADPH + H(+) = decanoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:44960"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61406"/>
            <dbReference type="ChEBI" id="CHEBI:61430"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:44961"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(2E)-dodecenoyl-CoA + NADPH + H(+) = dodecanoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:44964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57330"/>
            <dbReference type="ChEBI" id="CHEBI:57375"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:44965"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(2E)-hexenoyl-CoA + NADPH + H(+) = hexanoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:44956"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62077"/>
            <dbReference type="ChEBI" id="CHEBI:62620"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:44957"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>(2E)-octenoyl-CoA + NADPH + H(+) = octanoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:44952"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57386"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:62242"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="20">
            <dbReference type="Rhea" id="RHEA:44953"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(2E)-tetradecenoyl-CoA + NADPH + H(+) = tetradecanoyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:44968"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:61405"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:44969"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a (2E)-enoyl-CoA + NADPH + H(+) = a 2,3-saturated acyl-CoA + NADP(+)</text>
            <dbReference type="Rhea" id="RHEA:33763"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58856"/>
            <dbReference type="ChEBI" id="CHEBI:65111"/>
            <dbReference type="EC" id="1.3.1.38"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:33764"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Interacts with PEX5, probably required to target it into peroxisomes.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.38" evidence="13"/>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAD4"/>
    <dbReference type="OrthoDB" id="414540at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019166">
        <property type="term" value="F:trans-2-enoyl-CoA reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033306">
        <property type="term" value="P:phytol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052388">
        <property type="entry name" value="Peroxisomal_t2-enoyl-CoA_red"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24317">
        <property type="entry name" value="PEROXISOMAL TRANS-2-ENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24317:SF7">
        <property type="entry name" value="PEROXISOMAL TRANS-2-ENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00049559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RDW83074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="297" mass="31065" checksum="6169E254A57F5F36" modified="2019-01-16" version="1">MGTEHFSPYRSDGKLYGFVCVVTGAQQPVGQAIIAELAAHGAACIYACDKGTSGSAEALVEKLAKESPNTKIIPYPFNVAKEEETLGLIDDVLNAWGRLDVWVCSSGLLGPPSIDATTPADLQKCFEANSMAPFFALKYAPPAMGKTTPKQAYPNAAPKDQKYGSIIVVSSVASTYGGCWGPCYTMSSHAALGVVRAGVAVLKGTGVRINCISPGQIDVGVDLQGFDMRGMTSQFPPASLQAKETQERHNGLERSGLPVEVGQVAGFLASGFSSYITGHNMVVDGGASVMNPLTVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAP7</accession>
    <name>A0A3D8SAP7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine threonine-protein kinase ppk6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAP7"/>
    <dbReference type="OrthoDB" id="5420391at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42084:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PPK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42084">
        <property type="entry name" value="YALI0E26631P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW83405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="614" mass="66295" checksum="D8ED2D5FEE980A96" modified="2019-01-16" version="1">MSSDLLAEFDSFYQAPSQSNRSAVTPSTNDLAFLDGSISTTSGQTWQSNQQSAQRQSNATPAQTDIWGDMTSFSAPASIPQQPSSQSDIWGSFGAVADNPKPLPGLAVAQGQGNYTQPFGDGFSQITPGIQRKSTIEMFNSATEHRFTPTTVVNAKKPPPPMSSSKAEVLFDADEEQEADDDDDFGEFETVTSPAPTAPQQLDLLFDPVPVQTKPPAKRALKPMDVLVPSPNSLTSPLPYPQAPKSPSYKERTPFADLKVAPVVPASSQDTAASKPASAAPITAWPSYEAKESKYSPFADSPARAPAPASGFDEAWGDFADLPAETPTVAATSSIEEHAWGWDWNDRVPHAGSPPKRSKASNPLPAQKASSSTKASGPTPVPEAQKVVTVPRSTVPPTNIPPPSVLLTLFPALFNLPQTALFKPVSDQPFSLKNRIMSDPSTVKFLRGYLLIAVVAARIIAGRKLRWKRDTLLSQAMKIGPAAAGGKGGMKLSGVDKAETKREDREAADVVRLWKEQLGRLKSAVAAANSSNHDILSHLVIPEIGDVMHVNTLKGAMTDVKPCVLCGLKREERVAKVDIDELIEDSFGEYWIGHWGHRDCRNFWDEHEKTLKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAV3</accession>
    <name>A0A3D8SAV3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_05000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAV3"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="31"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW83509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="346" mass="38980" checksum="3549589098AD614B" modified="2019-01-16" version="1">MSAFTEHSVTYSANGEKELHYISTGPDDGQLLIFIHGWPAIAKTWKPQLTAFANLGFRVVAPDMPGYGKSTVTRKAEDYSHEVIITGLLALLKELEKEKAVWLGHDWGAGVVSSLAVVHPEVCQGIVLMTVPSHTLELGLEELLKTVNRDVYPESEYPFGQFEYQVYYERNFEQATAFFDKDVFGFTRIVYSKGDPANYGKPALTAKVVQDGGWFGGVTELPKVFHDIPFENLVVDEELFHELVAAMEKTGFWSANAYYMNHKRNREYNLQNGKNNGVLDFPVLFIEAKWDTVCDTATSNFAEPMRQHCKRLTEVSIEAGHWVALEKPEETNTAIAKWLADEVKDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SGX0</accession>
    <name>A0A3D8SGX0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoplasmic reticulum chaperone BiP</fullName>
            <ecNumber evidence="4">3.6.4.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Immunoglobulin heavy chain-binding protein homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BP5796_03920</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.10" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SGX0"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10241">
        <property type="entry name" value="ASKHA_NBD_HSP70_BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.10:FF:000009">
        <property type="entry name" value="DnaK-type molecular chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000153">
        <property type="entry name" value="Endoplasmic reticulum chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042050">
        <property type="entry name" value="BIP_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017784305" description="Endoplasmic reticulum chaperone BiP" evidence="15">
        <location>
            <begin position="31"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="646"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDW85595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="666" mass="72795" checksum="353FC1132E0CBF42" modified="2019-01-16" version="1">MARGSRSSFFMGLSALFYFVLLLAPLTAIAQSDQDPLQESYGTVIGIDLGTTYSCVGVMQKGKVEILVNDQGHRITPSYVAFTEDERLVGDAAKNQAAANPKNTIFDVKRMIGRKFEDKDVQGDMKHFPFDVVQKDGKPSVKVDVGGKAKTFTPEEISAMILGKMKEVAESYLGKKVTHAVVTVPAYFNDNQRQATKDAGTIAGLNVLRIVNEPTAAAIAYGLDKTEGERQIIVYDLGGGTFDVSLLSIDRGVFEVLSTAGDTHLGGEDFDQRVINYFAKKYNKENSVDITKDLKTMGKLKREAEKAKRTLSSQKTTRIEIEAFHNGNDFSETLTRAKFEELNMDLFRKTLKPVEQVLKDAKVKKTEIDDIVLVGGSTRIPKVVELIEEYFGGKKASKGINPDEAVAFGAAVQGGVLSGEEGTEELVLMDVNPLTLGIETTGGVMTKLIPRNTVIPTRKSQIFSTAADNQPVVLIQVFEGERTMTKDNNQLGKFELTGIPPAPRGVPQIEVSFELDANGILKVTAGDKGTGKSESITITNDKGRLTQEEIDRMVQEAEQYADEDKATKERIEARNGLENYAFSLKNQVNDDEGLGGKIEEEDKETILDAVKEATEWLEEHAATATAEDFEEQKEKLSNVAYPITSKLYSGAGGPGGDDEPSSHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SGZ6</accession>
    <name>A0A3D8SGZ6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GED domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_03867</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SGZ6"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF131">
        <property type="entry name" value="GTPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G07630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="5">
        <location>
            <begin position="128"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="4">
        <location>
            <begin position="821"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="57"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="549"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW85542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="952" mass="108065" checksum="E97D8B3A4F36AADB" modified="2019-01-16" version="1">MPPRRVKQERERQPSVPAHGIPTPESSMSNPSAATSFASQATHPVILDEGYETLEHTRRSMSPSVTSSFAPRKLHHKKSSDTVMDRNLPEAESESRAEVEAGLQIVGSKVKILVDAISKLRQFDLGHVVQLPELVLVGDQSSGKSSLMSALAEINLPRKSGTCTRCPANIKTSTADSWKCSVSLMQTWDYTPQSKRKPFPGWSPQPLVTKPFKTISSKIELEEVITWAQLALRNHHEDYKAFIPGSGHLAQRGEDYLTDSPAEYSPNVIMIEIEGPNLPSLSFYDLPGIFQAAKTEELNYLVDVFLGMSTTYIKRPNAQIICAMPMHIDPGNTLAAKIVSQLGANKSRCIGVLTMPDRMQANGKYDDWEEVLKGQAHRLPHGYFVTKQPGPDSALNQNDPQYHQLARRDEENYFDNDALWSDRWSTFRDRCGTTAIQNYVAQVFATQIARSIPEITRKIEKESEIIETALSDLPNTLNSNVQHIVRKVLGDFSNRVTRIFEKDSEFVFLHEWSSLTKDFRETILALKPKINFTHASDAFPEVIHVIDDSDDEDTADASPVAMRPQKRANENETAPASNKRPRYNVTPTPSTLNGHAIPNTPLRVPKQEENLQVPSTQRRRIMPAREPNRLLQSVFAEFIQQNPGQNFASIGDIRDRIEQSRFPGQPDNVSYRVKEEYCLQSVYYWERPMETLMTTAFTSLRKKIHEVLKEALKGYNETELYRRSRDALDDFLDKHEASQREKIEQIFELESDMVYTINEPAFNINKARELAILQKARRERRARMWVDKENANKKALSKEQMTHAIKKVTDEQLGIDPFKEELDLAGYIRGYYVTAGLRFADNVCQNIQGNLFNKIKGSIRDLLEGLLDLNKDGSEETCRMLLAEDSGVVLRRRNLIEQKEKLRGFSEELNLLKAKYYAPLEEPTEAPAAMNGNYSHQNADAVEEEEETHGYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SH90</accession>
    <name>A0A3D8SH90_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04001</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SH90"/>
    <dbReference type="OrthoDB" id="10327562at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW85676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="184" mass="20091" checksum="CD50E68A41663043" modified="2019-01-16" version="1">MSSTVSNEPPDEQTAQLYQTLLDKAREYYDAGNFNECREQCFRILDHTELPRYTCIDTLHLLATVSYFNAAVEYLELAAALINEADKVATSDMGQLLRQDNLDLTVAFERQKQVRMEAQKKKMSAGEGEQKGQEAQAAPSGSQGTDSAAGDDSQKIVEGGASAGEVGDDSGRWMLGLGSLKSDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMF9</accession>
    <name>A0A3D8SMF9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03184</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SMF9"/>
    <dbReference type="OrthoDB" id="10326061at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW87490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="197" mass="22138" checksum="3DB8EABF0323E3D3" modified="2019-01-16" version="1">MNKMVLQLFHRFITAHKLDIFKNRHITPHRLDIFKDKTISSMISHAKRVLADSNEQAAQNFTSEGPRSTAGSWTNSGDLAAKAIDTPSAHGAGYALIIVFVMSVAVFTVFGMIYRRDQKTRSRIETFNGHGMSWARRQTGNNGELVPTHIRRDRKIDLEEGYTEPVHQQTAAILPSQPAPAYTTRSPPKYSIFQADV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMJ6</accession>
    <name>A0A3D8SMJ6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_03224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SMJ6"/>
    <dbReference type="OrthoDB" id="67965at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF15">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW87530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="337" mass="38394" checksum="CBB71F3DE0222FCA" modified="2019-01-16" version="1">MTVVHALDNYYLAITLLITVAYQLFFFAIAWTLHFDKVTDFAGGTNFVVLAIITLAFSGHHNARQIIASLFIMIWGARLSAWLLFRIIKTGKDDRFDDKRDKFFPFLGFWIFQMIWVWTVSLPVTVLNSPNVTKYPQPDFGTGRDIAGVILFVIGFVMESVSDTQKFLFKQNNPDKSAICDKGFFSWSRHPNYFGEIIMQFAIFMICVSPAANGYVRGQAYKALYATILGPFFLTILLMFVSGLTLQERPGAKKRYEKGNHWRDYARYLNRTSILIPFPPQIYEKLPTIIKRTVFLEFPIYVFDPAKHSDASKPGAAEEGNARGSQSRASGDHLVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMM9</accession>
    <name>A0A3D8SMM9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ENTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_03261</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SMM9"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16992">
        <property type="entry name" value="ENTH_Ent3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000006">
        <property type="entry name" value="Clathrin interactor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF45">
        <property type="entry name" value="CLATHRIN INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="2">
        <location>
            <begin position="27"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="457"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW87567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="522" mass="54231" checksum="300AB480FC7700CE" modified="2019-01-16" version="1">MDLNSLKEAAASISLYDIKAGVRKVQNAVMNYTEMEAKVREATNNEPWGASSTQLKEIASATHNYQLLNEIMPMIYKRFTEKAAEEWRQIYKALQLLEFLIKNGSERVIDDARSHLTLLKLLRNFHYIDQNGKDQGINVRNRAKELAELLGDVDRIRAERKKARATRNKYGGVEGGAGLGGGMSSSRYGGFSSEDASSGGGSGGGYGGYSGGVYGDGGGFGGQSSDFQDTGAHGSGGGGRDRFEEYDEFDEGAAPAPGRKQRDASASSSGRRKSERATPKKAEPPKKKEPEVDLFSFDDPIPVSAPVVAPGASNAVADDDDDFDDFQSATPSVQASAPSFGIAAPTATTTSATQYAAPQPVSAPQQANLSDLVGFSSISPAASSNATPVNYSAFSPPVQQARPAAAPAPTSYQGSQPNYFTSVQIPAASPQQKPGSAASAVKPAAAKSSGGDAFGSLWSTASAGVKKTSTPSAGPALGQLAKEKASAGIWGTTTTPAAPAQQRPAQAQGGQSLGNGLDDLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMZ7</accession>
    <name>A0A3D8SMZ7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GIT Spa2 homology (SHD) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_03248</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SMZ7"/>
    <dbReference type="OrthoDB" id="5588096at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005826">
        <property type="term" value="C:actomyosin contractile ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902716">
        <property type="term" value="C:cell cortex of growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005078">
        <property type="term" value="F:MAP-kinase scaffold activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022018">
        <property type="entry name" value="GIT1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013724">
        <property type="entry name" value="GIT_SHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039892">
        <property type="entry name" value="Spa2/Sph1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056439">
        <property type="entry name" value="VBS_C3G9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21601:SF0">
        <property type="entry name" value="PROTEIN SPA2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21601">
        <property type="entry name" value="SPA2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12205">
        <property type="entry name" value="GIT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08518">
        <property type="entry name" value="GIT_SHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23742">
        <property type="entry name" value="VBS_C3G9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00555">
        <property type="entry name" value="GIT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="GIT Spa2 homology (SHD)" evidence="4">
        <location>
            <begin position="125"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="GIT Spa2 homology (SHD)" evidence="4">
        <location>
            <begin position="183"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="151"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="214"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="735"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="892"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="467"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="60"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="309"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="740"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW87554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="947" mass="103771" checksum="E7C12C9EDF4F542D" modified="2019-01-16" version="1">MNGRNGPLSPVSIGGGSEWSVSKYQNDTDSVYSPNPLNNRGNLASPPISSGSNGTMNGFPPAPGSPGGPSPPASIARSSIGTNGRKMSMSNEQFEAILSEHYVALKKYLAQSLRDEKGNPRPNRARDKLLRLSSVQFQELSTDVFDELLRRQQNGRRTPNGADNRTPPYLLPEKDFHPKRNQARQKLSTLPPPRFRDLATDVFFELERRFPRFAGGDLSRVGSPANSMRGPPSRNGASMSGAPRGMRPPSDASSIAGYSTRSESRNGPRMGPQNGGIPPSPGIPPGDFGRPTPKTFQSNTLVPNKSTMVEDDDEQTGGEDDEEESSSFNLEGAAGERERKMSSSGKSSGGSETDKKLIDDYQQQVAELREKLDAMEDTLKQKDDELANVLDEERNRSTTLDAEKKEWADLRVNLENAVADAQNLNDTLQSELDRVRASQAGTERELRAQIEELRTNGSGNGSGNKSLADADLQLENEELRAELMEQQKVTDEVRRDAQNFLKEMRVLSERSGASYEREEELTNTINRLEHEVQDWRNRYARTKTQLRTLRASSIGLSIQQDASKYTRDSGFTEENGLVKDVHVTKFQISIDELLQVARADDTSRVTEFMKAVIVNVRNITQDIDDSPTANEQIAQERAKLKSRISGTANNLITATKNYAGANGLSPVSLLDAAASHLTLAVVELVRTVKIRPTPAGELEDDDDGMLAPVDKTGFFPVRDPEPDNMAPPPIFMGLRDRSSADSSMYSPINSPRESRMSNMRPRSTSKGGWSGRPGSRGAPNGLNVNKSVPSMPMGTGFGIRTEESDVEELKIYLEDQTAVLVQTIQALVSSIRSEGGITAISNQITAIAEVVGNVVSSTQTAMSSTGNSELRVQAEPILDKLNRSRRRLIDAGQEGRAIADEGRDDDESEREWRAWTQSLPPIAFEIARDTKELVLRVDIIDGGGQAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SN59</accession>
    <name>A0A3D8SN59_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS transporter-15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_02922</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SN59"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="51"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW87228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="510" mass="57409" checksum="2A24CF3C7A2F6388" modified="2019-01-16" version="1">MESKEIFPELEPGSVEQKTSNSGRDLLDDRSIEYIDPKEERAFVWRLDLWFMTIGFLAYAFKYLDQGNISNAYVSGMKEDLQLNANELNYFTTYFNIGYMVMLYPSCIIVSHIGPSNWLPTCEILWGVMTCCLSTVTNVKQVYGLRFLIGFLEGCAWTGYITLISSWYLPHELALRMSFYNIAQPVGGMLSGAMQGALSTNLQGALGRSGWRWAFIVNGVCTIFIALGAFIILPGYPERQNPLSKFYLKPRHIEIALARTRRVGRKPQIGITVKSFLRCFTFWQLWVVAIAWATGPNNTPGSYFNLWLKSLKKADGTAKYSVGMLNYLPIIGQAVQLVAELLFSGFSDYFGVRLPFLLLHSTINITSLIILIIRPSNQHAYMAGWYMNYVGAVATMLLCSWASENLESEPEVRTVLFATGTVISYLLNAFVPLAAYPASQAPHWRIGAKLYLGFAIFAAVLYIGLHFAFKWEAKKKANNLGTGASTTEYVNTDSKGRAFERVREDLQHEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SNY2</accession>
    <name>A0A3D8SNY2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_03588</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SNY2"/>
    <dbReference type="OrthoDB" id="6415790at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008521">
        <property type="term" value="F:acetyl-CoA transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035348">
        <property type="term" value="P:acetyl-CoA transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024371">
        <property type="entry name" value="AcetylCoA_trans_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004752">
        <property type="entry name" value="AmpG_permease/AT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778:SF9">
        <property type="entry name" value="ACETYL-COENZYME A TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 33 ACETYL-COA TRANSPORTER -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13000">
        <property type="entry name" value="Acatn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="458"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW87894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="513" mass="56997" checksum="B624749D06E9585A" modified="2019-01-16" version="1">MAAPGAMTEVRRSGHITDHEDIDALSDLSEPLDEQPTAPTPVLSFLEKRNLLFLCTLYFIHAIPLQFSWLTMPIILRQQLSYSDVGTFLISQYPYSWKAAWSPLVDGLHHPRIGRRKTWIVPSLVLGGAVLFWLALAQDSLVTEVASGRSLAMVWLVLAWFLVMLACANIRIALDSWSINLLSPANVHWASSTATIGETAASLVSCIIFLGVTSLSSQKDENGKEEPASTRLFLGASATAFVATAVLLLVGKTEGDKAQHSQSIRKVYTIIWEILKLRHAWILMLVHMASMIGFITNDTITTLQLVKKNFSDLDLAVLAAVGLPFAIGGSFAVAKAFETRHPLEVWRSMFPWRLILAFVSQLTILFVSQYPDSPFRWFVVVLPYCLSVLFSVAMWVAFVAFHAQVSDPQFGGIYMSVLATTLNIRYDTLQFLCTEAIGMIDGSDDLTKPSPLIDGYQIVNLTTVILAIPIYWFFLKPATLHLETIDASAWRIKYQGSTDAMAYEMVVPLEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SPQ1</accession>
    <name>A0A3D8SPQ1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_03472</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SPQ1"/>
    <dbReference type="OrthoDB" id="4084551at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028000">
        <property type="entry name" value="Pma1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14610">
        <property type="entry name" value="Psg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017812410" description="Mid2 domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW87778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="27283" checksum="D164A2BDF57C9320" modified="2019-01-16" version="1">MLLTRLRCAALAILTWSWTTVAQSMKSTVARQASEVLQVCHNNNGTFAPFCRPENGTVLFVGRTYYITWDPSYFAATEGINATVLIMANYINSTGQVAQASSSPITENSQGYVPWAITHDWVKDFPSNNVTLFITPLNAASGTDGRTIEGPRVTVTTAPFPDHPHDREDEKSSNHALAIALPIVLVFLALCAIAAYLIHRKRGIRNMLGKGTGYGVRKSRAQRVGKAENAIQLQDHYLGSTMNKNSVDGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXU1</accession>
    <name>A0A3D8SXU1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SXU1"/>
    <dbReference type="OrthoDB" id="3766406at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="522" mass="59391" checksum="DD4187CBC37F69AF" modified="2019-01-16" version="1">MSPGKFILDDSSRALLEVFPQIPGRAEKSDLTVRKSKRSKISYSSSRRHLKKIPICPLLKLPREIIQHIAAILPRPTAAVFTFTCKSIYAALDKEYWGPYRHCHHKRKLLLNHWYWKSPLGIRLKDPVQLVQSSSSLSLLIEFATTRPEKAALLERCCSESCMCRKEWILNEKLLRERRQVLELLGRDVPDMIRCGRCITLHRPGRKAAAKDSADLRECELQDAHFGVGKVIYDGFTFPHLQQAMKISRNGDGNQTFLRSLSWSKTFHSADLTQVHHTSTKCHISNDTFLVRSQYWILFPSASATIYPTSTLLGPNSKICAHLEFGDPDKNYILHVQDDQQSVADKSLDEVLRCRLRHISPKRTDAPLAAVHCGFCTGIQQCLHCETEFVIDTKPIVHGAQGTAIILTKWLSLGRGEMCGDAQWRRHFATNSSHVLQPKSSTTTPVNDAYPGEKEHPEIITWPKGSIRDAFERGRAFEFENALSKRRERDMWAEVDEVVKLRVLQYGVLGSGEEKSYGKHKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXY6</accession>
    <name>A0A3D8SXY6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_02285</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SXY6"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF36">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW91120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="420" mass="45333" checksum="CD30F1E289C140E3" modified="2019-01-16" version="1">MAYDMMTFYKGNLSGGIPGVLPGPPPNPPTGYYWWESGAMWGSLIDYWYYTNDSTYNDEIAAGIQWQTGADNDMMPANWSQSMGNDDQGFWGMTAMSAAETNFQNPPSNKPGWLALAQAVFNTQATRPDSNCGGGLRWQVYPYLTGYDYKNSIANGCFFNLGARLAKYTGNSTYSDMATEIWDWTTGVGLIDENYNIYDGAHIETNCTDINKIQFSYNMGVWTLGAANMYNITNGDPVWKARVDALLNSTFNTFFPNNIAYEIACEAKLSCTTDMFSFKAYLTRWLAATTKMAPYTYDIIMPKLKASAEAAAAQCTGGSNGRMCGLSWSSGAYDGTTGVGQQMAAMSVVFTNLLAIDQSLGVPVTNSTGGTSIGNNNAGSQSVANPEAIKPATTGDRAGAGIVTTIILLGATGMFGWMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYJ2</accession>
    <name>A0A3D8SYJ2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Essential protein Yae1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_02558</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYJ2"/>
    <dbReference type="OrthoDB" id="48036at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019191">
        <property type="entry name" value="Essential_protein_Yae1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052436">
        <property type="entry name" value="LTO1_adapter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532">
        <property type="entry name" value="GEO13458P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28532:SF1">
        <property type="entry name" value="ORAL CANCER OVEREXPRESSED 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09811">
        <property type="entry name" value="Yae1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Essential protein Yae1 N-terminal" evidence="3">
        <location>
            <begin position="19"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="148"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW91393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="176" mass="19395" checksum="CBC0927FEC6AC15D" modified="2019-01-16" version="1">MADPFDEILGLEEQFYDEGYQQGMTDGIKAGRIEGRTFGLENGFKKYVENGKLHGKSLVWVNRLASLQPSTNSLQKPSGNAASESSDVKSTKLPVLSENTRLAKHVKTLYALAESDTLSTENTEEAVSDFDDRLKRAQAKAKMVERMVGEMEHDPSKILSSNDGSIEDVSVLSARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZ03</accession>
    <name>A0A3D8SZ03_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZ03"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00302">
        <property type="entry name" value="cytochrome_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000090">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF87">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ALND-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="490"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="550" mass="61546" checksum="1AB2E1621560D33E" modified="2019-01-16" version="1">MATQKFYLFGDAPSTAIEILVGEKGDLKALQTTLAATFHIAGKQELGFQNDAKALVSLEEVLDSQEPVAITLDGGKVREIQGPEGLPIVGSFYEIYPDHLGNHDRLFKQYGSVIKTTNMGKTIYLTNDPAVSVLAFSESQHFTKKITENHPLYGIKDNTAIFLGDTETANWAAGHKFIPPCMSPKAVRHYTPMMQECVRDSFSVFDELDSRNESWNVYQYMLKLASGFIGKIVLGMDFGHMDSVDAPLHSLVSNIATMLSLNKKVTSRGQWYASLPFGDPQKLRNLRKSLFSALAVEVDKARLTVGGDLQLHDAALEAKCVLDYLLRAVDSQGEKLNIDLVYSNIVVVAAAGFTTTSSLLSWLLYSAVNYPGQQERLLQELVDHGINEKTQWTPELSSSLTYLDSFIKETQRLHNPSYQPGRTSKTEVILPGGYRLPPNEVVVPALHAIHQNPKIWRDPQRFEPDRWSTEEVKNRPAGSYLPFATGPRGCIGFNLALAEVKVLLPELLYRYEFSRDGDEAVQYDPEFQLIRPVNLYVRAKKRTSWPEPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZ19</accession>
    <name>A0A3D8SZ19_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-galactosidase</fullName>
            <ecNumber evidence="2">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_02695</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZ19"/>
    <dbReference type="OrthoDB" id="2108802at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004352">
        <property type="entry name" value="GH114_TIM-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35273">
        <property type="entry name" value="ALPHA-1,4 POLYGALACTOSAMINIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G07890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35273:SF2">
        <property type="entry name" value="ALPHA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03537">
        <property type="entry name" value="Glyco_hydro_114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017660838" description="alpha-galactosidase" evidence="3">
        <location>
            <begin position="24"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside-hydrolase family GH114 TIM-barrel" evidence="4">
        <location>
            <begin position="43"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW91530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="275" mass="30558" checksum="8DA944913B3502B5" modified="2019-01-16" version="1">MAPITFFIAVLASMAMLLESTNGLSIPSFNKRATWWKPTAGMTWQIEISHELKDMSVDASAYDIDMFDTPATIINTLHSQRRYVICYFSAGTWENWRTDANSFAAADKGHKVGSWVGELWLNTSSPSVRNIMLKRLDLAKSKHCDAVDPDNTDAYDNTNGLGLTQQDSIDFVTFLANAAHARGMAVGLKNSGSIVSDRIVSLVDFAVNEQCVHYKECQHWTPFISANKPVLNIEYPSAGSATTQTTKAKYCNNPARAGFSTVLKKMSLDDWYMRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZ41</accession>
    <name>A0A3D8SZ41_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02715</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZ41"/>
    <dbReference type="OrthoDB" id="5865767at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39609:SF1">
        <property type="entry name" value="RFEG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39609">
        <property type="entry name" value="RFEG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="713"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="727"/>
            <end position="740"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="776" mass="85940" checksum="6714A09B57A6BF94" modified="2019-01-16" version="1">MDPTSSSFVHQIEHQIIYERYSTKPKGKLPDVLAKHLRPTLPKWPNPQASIGTHRCLEKGLNFWDITGPGLGQLKPLRREIQILLSDHSESLAQSLRESATVMFDLFMIGATKELACPTLVIISDKKPPRLQVITIIRERQVLQKYPGVLLGGCSRHPRYPKSNPPQSIATGRDSMEKSMLPLQTRVLFRESAGIPANGLRIYIPQPNSRKLRKATVGGFLDLNSEAFSNMTVGITVAHAFEVIEEDVAFDSLQDSQNRGLEFCFDGEEPYFINESAKGLVPNTTANQGNRSSMISDLTQSAAKLDHGIVSVTNEDYLDLKELGVLYSISKTNEGSNLDWAVIEITKQDLVLSYALTSNSGMLFPDFDFSDKKEDHNNTREDHQVITRAGSGRTMLGIQCGSSTFLKMKHSRSFEEVWTVELQGSLATGDSGSWIIEKNTAKVSGHIVAGDVVSGLAYVMPASLTFNDIQSQLKCTAKLTRKDKINAEPRAPTTIGIANPNPHVPTIMNTGPPWSSRTKTNEYFIPGNGIDWDVISGDITRYLGNDASVRPGTYVDPKTFQERNGYIITAYRNLTTAMITDIKADSERWDAERRQPIPVGGAPKGISAQDQGEMIRKATRSSVEYHASAHQPRQYYGPMPAAYLQPSSSQVYDYVPQYHSPGYSQPQQYATPTMGYAAAGYPGFAGYAQPRIPNVPAQPDNYYVPGASLEVDRGRVEPLPPRNPPLTTGQYPSSTSTYQQQPEINTTYYSQSVQEAPLYQIQPGELADPFHGRRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZA4</accession>
    <name>A0A3D8SZA4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NCS1 nucleoside transporter family protein-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_02810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZA4"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW91645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="557" mass="62097" checksum="D3B03CDDA05DADE5" modified="2019-01-16" version="1">MSDFKDISFYDKEAKSPRTAAPEVAEEGVMQCLDQPKESIFGRFLDYIRLDTGNQTGAAGRWSNADLDPTPIDKQVWRSRNFVTYWLCDAVAPGNLRLGSSLVTVGFSWKVTIAIIALGHFLISLAITANSIIGARYHIPYTIQSRASFGFYFSFVMVFIRMLVGFFWYGLNTYTGAECVNAVIIAIWPSFQNLPNHLPESANITTQMMTAYIIYFLIVLPFHYIHPRHLRWFFDVKTILCVPAIFGMLGWACHVSGGGLHTTLMKKDTTLHGSKYAWAFLSGLNSMLGNYGTMAVNINDFARYARNPRMIFIQILIIPLSFMLISFIGIIIAGAASDLYGEEIWDVLTIMSHWTGSSQSRAGAAFVGLSFVLGQLGSNVSANCISAANDLNAMFPEYINLRRGSYLIAFIGAWALTPWNILSSAATLLNFMDGYVIWLAPITGVLLADYYVVHRRSYDIDEMYLPDGKYRYNKYGTNWRAVVAWLMGCVPLIPGFANSINSSMGVSEGALNLYNLGYIFGFCVSFVSYSGISILFPPRSTFTPKTEPDDTTPEYVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZD5</accession>
    <name>A0A3D8SZD5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_02819</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZD5"/>
    <dbReference type="OrthoDB" id="9984533at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF9">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="6"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW91654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="302" mass="32280" checksum="061DFF407CA81C16" modified="2019-01-16" version="1">MATQLKNVTIIGASGNVGKLVLGAFDGASQFKVTVLSRSSSDATFPAGFTIRKTDYSESDLVAAFQGQDAVISVVGMGGFTEQKKFIDAAVAAGVKRFIPSEFSSNTLSPAVLQLLPVFGQKMEVLEYLKTKEASGLTWTAIWTALLFDWGLDNGFLGYDIKSRTATIWDGGKSVFTLTNVDQLRRAVVAVLERPAQTANKNLYIASAETSQKEILAALEGATATKWTVTDTTTDKEVSESMAKLGKGDMSGAFALVRATSFANTPNLRANYARDEVLSNDLLGLKMESVKETVARVVASST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZX0</accession>
    <name>A0A3D8SZX0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_01259</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZX0"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431:SF7">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW91865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="376" mass="40090" checksum="904FBC49211E9303" modified="2019-01-16" version="1">MASRIYAVIAGVGPGTGAAVARRFAAAYPVVLLARRAESYDTLVKEINESGGSAMGIATDVANADSVKAAFQTIDEKFGKDASCASAIFNASGKLALKPFLELTEAEFENPYNVNCKGGFYFSQAVLPRLLKGTTQTELKYPPTLLFTGATASLKSSAKFSSFAVAKFATRALAQSLAREFGPRGVHVGHVVIDGVIDLPSSKEYLKDAGPDAKIDPASPLLALPARWHGSSPTLCCYLGDNTLKVDGQKTLIDACIDEGDPRYMASDWSIEFRKLKLCEHPAKDLMKHVQAYLEAKEKDCKIKGVHVLNGAFIEVAFASFLGSVDADATVFGYYGDDTVPLEMATYAGAARYLSEVAVDPSANGFVNGEKVPVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0C9</accession>
    <name>A0A3D8T0C9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_02623</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0C9"/>
    <dbReference type="OrthoDB" id="10251741at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051510">
        <property type="entry name" value="SKI8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090:SF1">
        <property type="entry name" value="SUPERKILLER COMPLEX PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44090">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="145"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="223"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="265"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW91458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="347" mass="37537" checksum="509C1DB5DDB7430C" modified="2019-01-16" version="1">MPYHLPPHQNISRYRTTPPPHGVLCRTLYASYPTVTMSKQYLTTHTIDDAHVTDIFSLAVTPTQILSASGSSSIKIYSTASPEISLAQTLTGAHKLGCHHIVTSRNGKKAASAGFGGEVKIWAVSEAGEWAEEGKIVDCNKAGEIWAIALSEDGQFLASTTYDGRINVWDLADGRKKIREYETKGSFGLCIDMSRDGRFTASGHENGGVYVFNNETGRMLYSLPGLVKPVRSVAFSPAGTRLAAAGDARVIGLYDVKQGEQVANLTGHSAWIFSVDWSDTGEYLLSGSFDGKVKVWSIDRGVCVATHSETEKTLWSVKWLPKTGKSEAFATAGANRSISFYREATGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0E2</accession>
    <name>A0A3D8T0E2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative versicolorin reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_01363</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0E2"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009688">
        <property type="term" value="P:abscisic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G02870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43639:SF1">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="17"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW91969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="270" mass="28565" checksum="5A1D48AED3861244" modified="2019-01-16" version="1">MPSSTTAFNGEKSLAGKVILITGSGRGLGRGIALELGQRGASIVVNYANSTKSAESLVQEIELSGSKAFAIKADVSKAKEVARLFKEAKEHFGKLDMVVSNSGTESFKPEEEVTEEDYDRVFGLNTRAQFFVAQQAYINLEQGGRIVLTSSVAAQMSGVPNHALYAGSKAAVEGFVRAFATDCGHKGITVNAIAPGGVKTDMFEQNAWHYAPGATIDTPIADIEKGIASMCPLSRVAVPQDIARVVAFLGHRDSEWINGQILKLSGGSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0E6</accession>
    <name>A0A3D8T0E6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">sterol 22-desaturase</fullName>
            <ecNumber evidence="6">1.14.19.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_01437</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.41" evidence="6"/>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0E6"/>
    <dbReference type="OrthoDB" id="1372046at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000249">
        <property type="term" value="F:C-22 sterol desaturase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11082">
        <property type="entry name" value="CYP61_CYP710"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000021">
        <property type="entry name" value="Cytochrome P450 61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286:SF228">
        <property type="entry name" value="C-22 STEROL DESATURASE ERG5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24286">
        <property type="entry name" value="CYTOCHROME P450 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="480"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW92043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="547" mass="61682" checksum="1335A76686944E0B" modified="2019-01-16" version="1">MAAAQNASFVSPLADAKFAQIVGNPQIDGILVSLSQLSGWTIAFTLLAVLVAYDQVSYIVQKGSIEGPRWKLPFMGPFLESMDPKWEEYKGKWASGELSCVSVFHKFVVIASSRDMSRKIFNSPGFVKPCVVDAAHKLLGATNWVFLDGKAHVDFRKGLNGLFTRKALGIYLPGQEEVYKVYFERFLKVSEDAKMEPVPFMAEFREVMCAVSCRTFVGHYISDEAIKKIADDYYNITAALELVNFPFIIPYTKTWYGLKASEMVLDEFSKCAAKSKVRMAAGGEISCIMDGWVFAQLESARWREREAKGLSMEGLEKPSPLLRDFTDYEIAQTVFTFLFASQDATSSAATWLFQLMAQRPDCLDKIREEQLRVRGGDREMPVTMDMFDQLPYTRAVVQETLRYRPPVIMVPYLAKKAFPITPTYTVPKGAMIIPSVYPSLRDPEVYTNPDSFDPDRFAYGDAEVKGAKNWLVFGTGPHYCLGQIYAMNNLALMVGKASMKLNWVHHATPLSEDIKVFATIFPKDDCPLVFTRRTVEENEKFMASFKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0I5</accession>
    <name>A0A3D8T0I5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">TOG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_01481</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Microtubule binding protein that promotes the stabilization of dynamic microtubules. Required for mitotic spindle formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Interacts with microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Spindle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0I5"/>
    <dbReference type="OrthoDB" id="46159at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990023">
        <property type="term" value="C:mitotic spindle midzone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060172">
        <property type="term" value="P:astral microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024395">
        <property type="entry name" value="CLASP_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF9">
        <property type="entry name" value="CLIP-ASSOCIATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12348">
        <property type="entry name" value="CLASP_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="9">
        <location>
            <begin position="3"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="9">
        <location>
            <begin position="283"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="510"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="561"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="744"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="570"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="635"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="653"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="672"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="753"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="763"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="773"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW92087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1093" mass="119137" checksum="93984EA6BA19CA9A" modified="2019-01-16" version="1">MGEKITEEQVANLLAIIRTDASVDAKVNQINTIKSGIKQHNVPDPSVPVLFEALRIAMTAQQAALVNAGFSTLNHLLTRLSRQEPKYITKEAARTLPLVVEKMGDHKDKFRQVAAQCLTTIWSAAPMDTERAVKNTGMVSKSSRGKEACMKWIVQMHQEYGLQFKAFVPTFMELLEDADGMVRDNAKNAVIDLFQNAPNAAKSDLKKQLKITGVRPSIATTITNAIAPGVGQSAVEQEETEDPIIRPTFTKSVSALSSARPATPVMEVKIEHVDPAYVNTQRELEDIFRDMHPFFEGRESEANWLKREQSCTKLRKLNAGNAPSDFPEAFLVGIKGLLDGILKAVNSLRTSLSKEGCSVVQEIARNVGPGLDPMVEILLQNLIKLCGGTKKISSAQGNATVDIIISKVSYNHRILQHIWFACEDKNVQPRTYATGWLKTLLKKEVHHKNHIEHTGGLDTIEKCIKKGLADANPGVRESMRSTYWVFAGIWPMRAEAILATLEPTQAKLLENHSGNPNPPKKAEKAAARPGLGFSKSTTAPPKPSLRETMLAQKRAAMASKNNLPARPGSAMSSFSPVRSVSTADAVPKKTRPDSVMASHGGLSVAPMRPTKMRSRPEITRPATAGPYSVRRPVNAVNNGDSNTSPTSTKTQRARAPSAAAASPPKRGSIPRPATSHSSHPTNSNPSSPAKSSVSRVAASPRAASPRIGSPRASAARPKASALLLGSSPTKGDEEFTMVVPTLTGLKETYTEPAEPEETEEASEVAPELSLEQPIEEPIEEPETVASSPKPLQVYEDPFSSTDNPTTPKSTFSAPVLEEVAVNEDVAKIVRAGPDGETRKIVEMTPEKYKQNSRLLDSGISKVKAKSLDVHGFRKLQSLIRDNKATWTDEKFDALLLGLFEYLESPLTSLTPEKVQDVKAQILATIKLMYRKDRGSFRTHVPVALESLLVTRSCYDARAHIVSGLELLSDDLITLAEPKETIIAITSRLQKEEMTVEGSRILSMGLHVLKSLIESSKNFAPGDEEVVELCKLASRCLESSESGVRMDAVQLCVALHAQVGETPFWTNLEGVKDDPKSLITYYIVKRQREVAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0M6</accession>
    <name>A0A3D8T0M6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_02723</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0M6"/>
    <dbReference type="OrthoDB" id="3560968at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017582733" evidence="2">
        <location>
            <begin position="18"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW91558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="135" mass="14934" checksum="D895B8DCB978ECDC" modified="2019-01-16" version="1">MKITLAALATLIVLVVAAPAAEPAQMGTQAYRREAEPAQMGTQAYRREAEPAQMGTQAYKREAEPAQMGTQAYKREAEPAQMGTQAYKPYKREAEPAQMGTQAYKREAEPAQMGTQAYKKRDVFGTRPSLLEYIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0Y7</accession>
    <name>A0A3D8T0Y7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ammonium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_01627</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cell membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0Y7"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3430.10:FF:000003">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018047">
        <property type="entry name" value="Ammonium_transpt_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00836">
        <property type="entry name" value="amt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF15">
        <property type="entry name" value="AMMONIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01219">
        <property type="entry name" value="AMMONIUM_TRANSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0924">Ammonia transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="32"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="10">
        <location>
            <begin position="35"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="453"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW92233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="484" mass="51829" checksum="594D1A30F1FC51BA" modified="2019-01-16" version="1">MSTPVYNASEPYGGDVTQVDVNAQYVGLEYHYTYLVFCGFIVWLIIPGIGLLYGGLARRKSALACLFQSLMVGSAVTVQWMFWGYSLAYSRTAGPFIGNLANFGMIGVGVAPSPGSAVIPEIVFCLYQMLFCACTVQIVVGGAFERGRIIPSLVFGVLWATIVYCPIACWTWNSNGWLYNLPSLDFAGGGPVHISSGWSALAYAFVLGKRKHTGEKSHGKAHNTSLVFLGTVLIWFGWFGFNGGSALNATVRAMYAAFNTNTAASTGVLGWVLVDYFKHGKKFSVVGACEGAIAGLVGITPAAGYVSVWCAAVIGFVTAVGCALLQNINEWIHIDEGLDVFKLHGIGGMIGSFLTGIFATSKISLLDGSSNYPGGIDGNGIQVGKQFAEITAISAYSFVVSCALLYLMKWIPGLHLRVSEEAEAKGLDFDQFFDEQIGDWGMFHELSNRHDGRAMSLTSPSTPPVKEVSELEAGAESEDSIKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T104</accession>
    <name>A0A3D8T104_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_01573</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T104"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="31"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW92179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="578" mass="64100" checksum="984D18BE5C089D52" modified="2019-01-16" version="1">MDQKDSENVLATVQSGGQVSAAPAPPKAAKACVKCRRLKMKCRIDEGPACRRCVRAGTQCIFKPRANAAASRLSSPPTATYEPAPVGWSLPSTLTAQSFQGVLSRLDAIESFLALNAKPSPAATVATADEDERGDPKDLSLLGLWAALDQLRESPRQVPNSRIWKQNTVKQLWLDFHKNMPGLHFLPTKQTFSAPTPLLLASMLYVSSLRHSEPELAALSSDYFIIMCGAIAELTIPPPELDHTVRASSPSTTEENAFQDVLGLILAGLTCEASTKTTGIWISIGYRLVLESCPKEVDERSREWQRLFSGLQILDLEHASLHMSCPIIPLHAPLSRLHVSSEDDIYSLSQMMHTGLTHFTGRGLPTIWSCFSTAAETTFLSSPFTPVDAAVIRDWATQLDRWLARFNTQRRFPSEHGRMLIFRQYILHRLLVLSIYHPARGFNLFSTSTTSVERRELLVSARAALKLQMDDRSIWANWDFVMITWAALLVLQGIEGGVGEDDDLPMVQDLLNTLRTTQEPATGLRNQLANKLEATFQSLHTPPPISPAVMPIPMSDGLSWSIFDEMSLQFAYPDQWPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1K8</accession>
    <name>A0A3D8T1K8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_01804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1K8"/>
    <dbReference type="OrthoDB" id="4034134at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038872">
        <property type="entry name" value="Put_GTT3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41807">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41807:SF1">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="287"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW92410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="350" mass="38909" checksum="68D6FD67BF16CFAC" modified="2019-01-16" version="1">MSGAANWLRQQKKGELLELADSVGFTEYDGMRKTDLELALNDYLTKNSTELSSDTRLQPFYKRRSEWSPIKRETSIITGDGETTVKRVRRRATKVAEEIANVIASATDDETEAELAASRSRTALTRTPARSSALTNITFPANVPLPPSPAVVADAIDRRTAVIRSKLNEVYTESGITETAQATRETLSTVTAIQAILVAYEVYHLRPELLTSRYAFTIPANAWLHTSEHAVKIPDMFLLLTSSFWGPFLLWLSTSVLLPLFASYFFNLTSKPKTRSNNTRYEYTFDPLIFNIAKALLTFVIYGQDVTFGGLVNLESVARINSALYGGWQSILVGSGIGILVTMYEAVLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T206</accession>
    <name>A0A3D8T206_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">GPI inositol-deacylase</fullName>
            <ecNumber evidence="12">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BP5796_01422</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="12"/>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T206"/>
    <dbReference type="OrthoDB" id="348976at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050185">
        <property type="term" value="F:phosphatidylinositol deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006505">
        <property type="term" value="P:GPI anchor metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000056">
        <property type="entry name" value="GPI inositol-deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039529">
        <property type="entry name" value="PGAP1/BST1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056824">
        <property type="entry name" value="PGAP1_TMD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495:SF7">
        <property type="entry name" value="GPI INOSITOL-DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15495">
        <property type="entry name" value="NEGATIVE REGULATOR OF VESICLE FORMATION-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25141">
        <property type="entry name" value="PGAP1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25140">
        <property type="entry name" value="PGAP1_TMD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 12" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="809"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="911"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="937"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="982"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1026"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1101"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1128"/>
            <end position="1151"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="14">
        <location>
            <begin position="214"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase transmembrane" evidence="15">
        <location>
            <begin position="814"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="92"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF25140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDW92028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1165" mass="129952" checksum="A5448ED6A507D78E" modified="2019-01-16" version="1">MRRRSSGSAAEEEGEETAPSSNADVTSLNNGAGGRSKTDNSVVRRTSNDPQSSPRKENPQRTSHELDRRKSSDQRPSAARSRRPSNTNWKSSEARNGHIEKPSGEITIIGVPSADTMAPEKTPDAQVTARRSRLRSPWSCSWLTFITTALATLALVAIVHSFNSRQLDTKGCRMSYMRPSFAKLSDFDTEHTRFASKYSVYLYREGGVDEDTKVKGVPVLFIPGNAGSYKQVRPIAAEAATYFHDTLRHDSAAINAGTRNLDFFTVDFNEDITAFHGQTMLDQAEYLNEAIAYILSLYHDERRSQRDPDLPDPTSVIVLGHSMGGIVARTMLVMPNYQSNSINTIITMSAPHARPPVSFDAEIVRTYQKINDYWRQAYSQKWANNNPLWHVTLISIAGGGLDTVVPSDYASLESLVPDTHGFTVFTSSVPNVWTGMDHQAILWCDQFRKVVVRSLYDVIDVNRPAQTKPRAERMRAFKRWYLTGMEAIAEKTLSQKEPTTLLTLEDNSNSIIAQGERLTVRKLGQSRRPRAHLLPIPPQGTPGGKRFTLLTDQRLDKAGESGNLEVLFCSVFPLHPGQSATLFSMNMDLSGDSSGSTRLACKNAAADAIVLPASTRTSKKPFYLDGEDEITPFSYLQYDLEDILDHQFVAVVDKATAPTPGWVIAEFSDNVHSHKIRNLGLRRLLAFGMKMKLPSNRPMVAEVRIPALHSSLLSYKLEVSEQACGDDPQLFTPLLRQYISEPYESKYFVNVKQANINLHGVAPFMPPPLTNKNNQDGLSLQFWTDPTCNSSIRVSLQVDIPGSFGKLYMRYRTVFAAFPLLIVALVLRKQFRIYDETGVFMSFSEGLDASLRQSLPLVLGVLTCLAISLAKTSSEPPRPNSGGFWPWRSNATESVIDFTKNDLLVGSQDPFFWFMVPLIGVVCVGVCVFFNYATLALTHVFGMIYGMVTVKPAWLRNDDRRRQSSAAFVSSTPRRRILTTSILLLLVSTVIPYQFAYLVACLVQIATSTRALKLAREARSTTNSNFYNYAHSILVLMLWILPINLPILVVWVHNLAVHWLTPFSSHHNVLSIMPFILLVETLTSGKMVPRVTSTFRHFTSVVFFFIAIYAAVYGVTYAYMLHYLVNFAAAWLVLIHSSTSSWTFAGLSSIFEPESPSGRKGGKTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T258</accession>
    <name>A0A3D8T258_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02047</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T258"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW92653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="57" mass="6332" checksum="FF1DD94E31387FE6" modified="2019-01-16" version="1">MIIYNLIKKAKDKKRDKEAKTNSAPVVASTSTPAPAIPDEHGLRERWNGGDVRMINV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T264</accession>
    <name>A0A3D8T264_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_02040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T264"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF1">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="4"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="284"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW92646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="768" mass="84012" checksum="6F5EBEDF4E1E33A2" modified="2019-01-16" version="1">MAAKRVALAGATGNLGVSVLEALLGANLGVTVLSRIHGNSSKLAPHPNLTIVEVDFNSIPSLVAALQGAEVVISCLATLGIGNQNTLIDASVTVGARRFISAEFGMDSRNPRCAMLLVCMPKVDTQKYLQEKANSHPVSHIPALPTDYFWTGDCNTTTLADIAKAISGVITYHDQTANRILYIHLTTTTQNKLIQYAKDKDSRDWHTVSKDTEEIRQESLAELAKGTQGDINAAMNGFCICASWNPEYGCNFSSHLDNDLLRFKTMTEAELRTLWMKKLPSRAQKDSGHAPRVIGGGNNHRDRTHSPRASSSEILALESQQRSTDALNALSSNAESVEILLTRWGEQIFQCGFAAIFGRWAGRYGCPFVNDLASDISIAPMQLFEELDACMDKQLGCDPSHASVILERREERSGEIEQSLRRAMQSFAARWLPRAMQGTSGGPVHYEEIITERWRSSRRDMLKVINRTSYRSVLTLYLFGQTPVPSGISEEEELDGISGVSAWSDAATSSAASPNLTPSSLNLEMRAYWAAVAWDTSSSVTLNIRSSLTSGLKGACLEPAWRLVKGFLVGSFHARSEEWRKKGYEVSDETASQIISAAAICRLYTWKTIASVKEALAEGVEESDALFAWNALLDALEVYKVTIHPLLRIFQRPKIGLESEYTIAAPLEECSDPTDANSAAYTTGKPITVSLVAIDPYPHHVVASVRLMAKAINRKYQAGNIKPEAYSYLSSTLGKALEQLPRRSKTVQSACEDWPEPVLFDAAAAGDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T734</accession>
    <name>A0A3D8T734_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_00130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T734"/>
    <dbReference type="OrthoDB" id="3210378at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW94367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="737" mass="81646" checksum="D3EDA38D1BD8B0F0" modified="2019-01-16" version="1">MESPRSRPIARPGSAGSNSSGRFSYESRAKSPLSIISSVDSYETGRTSLESQTSFNSSLARRGPTPVYAHGNGIPNRAPMAPMPMSAKNGLKFESTSLPPTPSRLGPQKGAVSKTGGGLAGVRYLRNLNPGEGFKKLPKEILLVILQELRRSHVEAGSLSCATCWMRDCCNLALSCKKWWRATRNILYEDIQLIGCDSVMHTKKRFKMRYGTRLTLLRRTIREQPDLADCVKTLKVPSMPEAAKTKKEREEYLDLVASVIMSCPNLERLPGFYPAYTHEFSRFVHAISTRTKLLEQVWVIDPSPFQRQHRYTLSEDSRNLYPTLIPGLLLPEQCVEFLDYHSNWDNLQTLFLHCNPGGTLDSALLMDIFASLPSLQHLNVSSFPAPAFTDDTLLSLPPLKSLRLDSVPGISASGLSTYASLPTSNTLASLSLISIPVLSLPALARLFSRLASLTAFTISQGPAPSLPMGEEIFMHPYLASSTLQSLHWETTSPLSEQATDILSKSIQFNGFPSLKMLRTPADYTGSFQALCKPRDKIELPGDRYRNIHQPLPSSQSLPNLPSPSPTKGSFFGGSNNSQASFSMPPSPAYVTSPTKSVFSFNEKEEEALSSSGGRSLAQARRQAQSRIEGADKHPQFHIIVWDDDNQFVERFAVGSFIGQVQSKIWYSLKPDIEGMDEAIVRMSTLLDGGEEVAMRNGCTGNWNLDVDKSGKGRNIGKEKWWHTERGRWKEVGLEKFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7E6</accession>
    <name>A0A3D8T7E6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_00232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7E6"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW94469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="87" mass="9242" checksum="71E8F39D3DDF4F0F" modified="2019-01-16" version="1">MVHQASPPAPSLGAKGFCWRYGKTRSHRVPGRKSQNAAATCSSGPKARNSEEEEAYRTTRQLPPGTLFVSYLVGGLKVASPDPAQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8K1</accession>
    <name>A0A3D8T8K1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_00091</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8K1"/>
    <dbReference type="OrthoDB" id="10284988at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017573862" evidence="2">
        <location>
            <begin position="17"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW94328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="187" mass="20033" checksum="AD35D5508F9BBC43" modified="2019-01-16" version="1">MRLFLTSALFLTSVTCNPLPGSAGANLKDIVQRSAEPVTPTTPTFPMDITQRSPEFAPREVEIKVREPANAVDDHNWPGQGCNAKRGTDTDWANCCAQKNKRGEAADHGCGCAGWKDKRGDNIDGRTCCAYAVKRSSVNWGCGCGASPYDKRSQDANSHGRCHKARSLDPANASCGCPSQGDGEDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8P3</accession>
    <name>A0A3D8T8P3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_00679</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1562405at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019441">
        <property type="entry name" value="FMP27/BLTP2/Hobbit_GFWDK_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019415">
        <property type="entry name" value="FMP27_SW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019449">
        <property type="entry name" value="FMP27_WPPW_RBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045167">
        <property type="entry name" value="Hobbit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678">
        <property type="entry name" value="ANTIGEN MLAA-22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15678:SF6">
        <property type="entry name" value="BRIDGE-LIKE LIPID TRANSFER PROTEIN FAMILY MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10344">
        <property type="entry name" value="Hobbit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01214">
        <property type="entry name" value="Fmp27_GFWDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01215">
        <property type="entry name" value="Fmp27_SW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01216">
        <property type="entry name" value="Fmp27_WPPW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27 SW motif-containing RBG unit" evidence="5">
        <location>
            <begin position="1145"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27/BLTP2/Hobbit GFWDK motif-containing RBG unit" evidence="4">
        <location>
            <begin position="1265"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="domain" description="FMP27 WPPW motif-containing RBG unit" evidence="6">
        <location>
            <begin position="1669"/>
            <end position="2190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1072"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1913"/>
            <end position="1941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2008"/>
            <end position="2037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2507"/>
            <end position="2684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2792"/>
            <end position="2851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2918"/>
            <end position="2952"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1840"/>
            <end position="1867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1079"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1094"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2576"/>
            <end position="2589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2611"/>
            <end position="2624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2632"/>
            <end position="2663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2919"/>
            <end position="2928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW94916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="2952" mass="333899" checksum="618A8FE4F87DA438" modified="2019-01-16" version="1">MALLNPTFVFGLLVLLYLISFILFAIIRIVTGVSIQRVGYFSLRRLAYTPRDGIKVEIRGLGLNLHRPTFAQPTWVSVVLTELVLTVDLKTTGNDKGADGEDSNEEVEGTDGPNSEFEPQVKSNPLPRQSSLGPQRSKSWEQLTKLKERIKRLHRKIKWIRLVDVVATNTSINLVDVGTLQVGSFTMAVDTRRKTVDRGRMFSHLKSVKKDQRPAEWMITVRSILFTPAGRDSLEVLDHATLNIHGLLYKELDGLRDASIALKLGRVHIPFDDINTCVNRYKGCKKLYKRKGSKSEPTEISVVDLIEELDRPGSREEKLVQTVSDSKEFISSILRGIKEVQFAVSYVGFSKQIRAIQPNGGPIYLNASMKEVGVDLHRLDQKSPAHRMYFSRKDVAHQALVAALSIAIGLDDGHGQSERLAYIPMATTTIRTTLPSKTVEFGEDNSADERNANILFANIVVTSPSVDLDPKHLPLVLAMLRQNPQSRPSPAAQRHILISRLLPKSNVKFSMHEPVIRIALPAVEKTDEDDFDLLISSISSISLDIESSHSAVGELHYALASTVRLQAHDLYYQTSSGSRYDLLQTESLELKVQVSANPEVYVIASANLQTFSVHMVRPEISDGVRQIVRQLRLNVEPDKKGHAKNSKDPNFIRALPPWLLHFQLQGSDFSAEVAGVDEDISEDTRGVALQIETWTAEYRAQKADSIERRSSRRRTGSRSLTPDTELLLKIPHSPPRKQSHPTDGRRLAIHVRGLEAYVVESAEKWEIEPFIAIPRFEVALSTKHDSQGPIFHVNSHVKTLLIHYSLYRHYACGVATTVLRKAFVRTRADVEEAEKARAAISIPDHLSPMSPLSSDGGYGEDAQDFPFSYRELVTVDLKATLVQIKANMPADPPAMLQIYGLETGRHRWSLPFFQAKLIRLYAEAPKMPRVWARIVSIKAVRVDFREHRKKLSNGALHDERVIDINTEAIRLGVPHQLVIHKVFDNFVNTLKAIQQLHHRFVTGTNEYILEKAPEGPKHIPRVSIRSRALLFEIEDGAFEWKLGCIYRAGLLEQQRRIAREAAFKVKAKKIEEEEMRNNPSRHRNRSAHPRGRSKYPEDSRYRSKSERGVSDDRGRSRSTGRGRRMRYDPDGTCGLSGNAKISIGEAHERLQRLNAQSWKKRIDRIFGMQKHNMKELRGIFWGPDELPDDMEETENILEVPQRPALMAALISDLHITIDKPTFPMKDLPEFLHQVGKGIPRDMKYALLIPMHVQIDMGEARVTLRDYPLPLLHVPAIRPGQSPRLPAWSLKTNFVIGEEFRGPESTRHVKVNIVPRNDRDCGGFAIDVRRTVSPVKSYSDINVSINTSFPTRITWGSSYQPAIQDMMMVFETFTKPQVDPSDRTGFWDKIRLSFHSRVTVAWKGDGDVHLMLKGTRDPYMVTGNGAGFLMCWRNDVRWDICRDDDPRKFMTVDSGEYVLAIPDFSHQARKTAKKHRDADGDDESVMSTDSFKRGAAFKKVVMKLSGNVQWLAGLMFERNLEGGKRSFDFKPHYEIVLREPRYAKATDGLVYDAFRGFRSQHIHMSIAVKAPVDRDWSVNNTSKSRSYNTVHLTPRFFTHFFAWWSMFGGPMSLPIRQGKLWPGIEKSSKKFGRHLSTIKYNLLLAPLFLSHIYKHKEVEDYAEDVVSATGLKIRLDSFMLDVHQRREEFNTHDKGKKTSSKTSGMKMHRAQLDLVRADIRAISASIAGTTPEDLRKASAPSILVSQQDQVTTDLSHFEIPDNDFSWIDMDDFVELDWILPSEANPETKIMPLAYAPRFTYFRQTDHGDIIAGDPDRTSPFGNEPTHFCIMSKDDDPRLVQCRLIQARLDQLTEQMQNHTRSLGDAELEYLKNENDATLKSDFEQLSRHDGVLRDKKIFLESMLHNMSTRIHTGEKKAVPNGDGDSDAEMRSSTEYDPATGGMDSHPGADFVSDFNNRFVIHNMQLKWNNMLRNIILRYIHQVSQRRGFVYYLSRPAVKFILDIVEEQSKAKVPKSRGPSPETTTSAGPSQKAGHSFDGSGEVEARIKEILADGKKFVNADDPQAYEVENQRVSTENLDSNIAQDFTPQNSYHLRLIAPQIQLQSEKNPKAVVLVTAKGMELKVVEVMDKDRMFDDVSGLVQRRFAVEMDSTQFFVTHQKWFSSQLLSLYSGSHYGTPAGSAWPPWVPMEVMFDFSADPFGFKRVVQKTSASLRYDKYNTLRLKYNDEITGSEEAHASVPNNLESRMDHLWVEFPQIRALCNSAQYYAMYIIVLDLLMYSEPLEKTRSERLEKIMLASDFSDLRGAPEMVIRLQERIRQLEEIKTQFQINSKYLDRKGWEDRIALDRDLTSCEDELFFMMKAITTSQRKYDGAQSSGLLRWNISSNQIVWHLLRDNNQPLMEFQLQKAEYDRTDNSDGSHINLMQIGKIVGLNLLPDAIYPEMFAPYSDAERGTFNEGGNQQMLRVYWYMLEAIAGIPVMDHFEVNLFPMKIQLEREVGKRLFEYMFPGSKEDGSGTGKNSSPFMVKHMQPPDNDEEEEESKEIPGTSGNHLFAIDDERRGSAASTRAGSLELRLRPTLTSEARPTTSSMPKSKPMHSAQSSDGSHHFRLFQSNKSSSSKAPSIRSMNKKPSIESLSTSITSRPMLNRSSTGASNIDKASTNGEAKSTRFGIHRNGGKTKEKPSDDLTKMMSRASNYMTLAYVKIPSVVLCLSYKGKGERNIEDVHDFVFRLPLIEYRNKTWSNLDLALALKKDVIRALISHTGAIIGNKFSKHRPNTAQQSRLRELATSSVLLTPSSNDNSHDNSDASSTFAYSPTDTRRSERSKSPRRSFTSNLTGNGSHRPESASSSLVSLQSFPRSQTYPANLMMTPAKKEGSDLAGSSGISTAKVWAESTANETRNGGPGGFVADTLRKLKKKDLNSSSHTTMTVSEDDEIDRTSSKKKSKSLLSKVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T987</accession>
    <name>A0A3D8T987_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein bL27m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_00850</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bacterial ribosomal protein bL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T987"/>
    <dbReference type="OrthoDB" id="1867012at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000042">
        <property type="entry name" value="50S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001684">
        <property type="entry name" value="Ribosomal_bL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018261">
        <property type="entry name" value="Ribosomal_bL27_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL27M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15893">
        <property type="entry name" value="RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01016">
        <property type="entry name" value="Ribosomal_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00063">
        <property type="entry name" value="RIBOSOMALL27"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110324">
        <property type="entry name" value="Ribosomal L27 protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00831">
        <property type="entry name" value="RIBOSOMAL_L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW95087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="255" mass="29061" checksum="C60ED754C570DE09" modified="2019-01-16" version="1">MLLPRLQPPLRAAIAAIGRSATLGSQPCLNEAFAQLAIKPSLTFVRHASHNQQGAVNKAKDGPGKRLGAKKSGEQYVIPGNIIFRQRGTHWFPGENCAMGRDHTIYATECGYVKYYKDPEKHPKRQYIGVTFERNQVLPLPRNSQRRRRLGMVATKMEAAPIIEEARVDMIASDEGTIKALTKKRKERKGEEGRDLTLRPGYMYREANWQIGRAAERANIKVRQFKPRDRWTAWRKSTIRKKSNAEKKSLGRKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9A8</accession>
    <name>A0A3D8T9A8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_00878</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9A8"/>
    <dbReference type="OrthoDB" id="10644056at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017585612" evidence="2">
        <location>
            <begin position="21"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW95115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="235" mass="24296" checksum="4B01D79D6CE51B99" modified="2019-01-16" version="1">MKFSTATIIFAASFFSSVQGAPLAVDGSGLALREPGPPPPRHGGNRPPPPPHARDVEEREAEAGPPGPPPRHGGARPPPPHARDVEEREAEAGPPGPPPRHGGARPPPPHARDVEEREAVAGPPGPPGPPPRHGGARPPPPHARDVEEREAVAGPPGPSPRHGGARPPPPHARDVEEREAVAGPPGPPPRHGGARPPPPHARDVEEREAEREAEAGPPGPPPRHGGARPPPPHRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q594</accession>
    <name>A0A3D8Q594_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_12907</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000024">
        <property type="protein sequence ID" value="RDW56840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q594"/>
    <dbReference type="OrthoDB" id="5392779at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47840">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="24"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="90"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW56840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="731" mass="80695" checksum="E75542262863E099" modified="2019-01-16" version="1">MSSSTMPPPAEEHRRKRVRKGTRSCWECKRRKIKCIYPAGDNAICASCLDKGTKCLGQEYVDDQAVHEDAGNAALGQRVERVEMLLETLIETGSQRPRENSAPMAPANLLRSSSTPDTIYGSPSRSRSLPEGVQGQPAEASTTMPPPHSVSGSGSSPPASADHEYTSGRTEQLRRQLAALLPCQADVDYLSSTSGWWFLRRHILPHLLAVPEAGEHELQIPFNVSTVAASHPMTIARLLLCVALIIQQLPLKIDPRRFQTKVPPQELMEKVITYVTAAVTGDDELTGSVEGIECLVLQTVYQINAGNLRRAWLTFRRAINVAQLMGLHRVSLRTSQDVPDPKETRRHNLWYQIMRGERFLSLMLGVPSATGSTPFLFDDHAPWLSTEDRYNQHLCQIAGLVLTRNQADCTHAFSATQEIDERLGLLAKQMPRTWWEIPTVLIDGCTEAAASQLERTLCQIWHFELETLVHLPFMLRAATDRRYEYSRISCLSACRSLIRRWLVICSSQSTIFVNTLIEFQAYTATITLLLGLLGPAPSVANPVTLKERDEDLQLVETVVHILEVLKQRGAGVHVVNQGISVIRTLQGVLRNGGIPSKSLRLEIQHFGTISIASGGSVQSLEGERILGATPRLPVPLAGVTAPDQAGGSNSTLLATSVRLPSMSSLTPGDQEPVTINDDTAWKNNTVLQFTSSQFPTFDMQAMENPSEWATESDVLFFNSLLDTDIGINSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q5Y6</accession>
    <name>A0A3D8Q5Y6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_12891</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000024">
        <property type="protein sequence ID" value="RDW56824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q5Y6"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW56824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="230" mass="25192" checksum="A6B234FC13EAEA95" modified="2019-01-16" version="1">MGSLNLACTGTLRSAVVRLILDRIARLQSSAGSATPVGLLACGPSHEVIRRESWRRRHGQGDLSFLPRTLRTLQTPGTSAPGLATTDNGHRRHRWLLFFFNVGMRASELNCLGVSIVIITSPLCVCFLTDSDAQIFYFGAARTQAIERPSIHSAQIRLLCSHPRSPAQGAKCRGSRAWRHPHRDLIEDQSAERALSKRLLIRGAVEALSAADERRRAATATAATGGHYRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q641</accession>
    <name>A0A3D8Q641_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_12719</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q641"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW57269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="107" mass="11838" checksum="E0DEB6F31674F12B" modified="2019-01-16" version="1">MAPTLSAELLKAKEDAKCLAKTPAPADLLDMYAFYRQAVQEPPFESAEKPSKFALKDRAKYSAWEKVVKEGVTPEAAQTKYIDHVEGMKKTYGFDPSKEPVLWGAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q699</accession>
    <name>A0A3D8Q699_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_12796</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1310.10:FF:000001">
        <property type="entry name" value="Cullin 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin family profile" evidence="5">
        <location>
            <begin position="1015"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW57346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1375" mass="155002" checksum="9B93094F6C1BE87D" modified="2019-01-16" version="1">MVKLGHAHWADPDRRDSIEQSQSMRMEWASKIPLLPSRVTTCWPAKLPAQSCLRDAMHQLEELLILRYLDFWQGEPNPPGCVWDPAMHGKSVDNAQPTIVLGVISDKFRRNAKRIFTDHEFRLDPRGIAVEYYHKGLDFCSGSPEHGQAYTEVPTAAGLGSWNQGQPTINGALIRVGSVECTLGGLIAVDGEIFGLTVAHAFEKGDINARGEFSAAWAFEIGLIPETAVNQPVPRPTLRRPGLGQIGYLQQKRLAPTSPALKSGDWDWALCSLENVSSYTPIPVPNGATLLPKKIVEEDPSNSPVLVCTESATPIRGTILQDYSLVALPGSRMFQRMWVVVLERRVVPGDCGAWVIDANENDLYGHIIAGKPGTNTAYIALARDIFRDICNQVGAFQVTMPSLADLTDVTQNAIQLGGSTFPEIPKVSTGTGGQVGTAGIIKSLQESATQGYQRKEIIGPSERQGSSRMDSLDDQIPGWTAAPDIPDMEGNELIAASQDGDTEKVQQLLRAGTQQSVGAGLREAAKRGHLETVQAFLDAQVCGMVALEDALIDTAGTGHTEIVQLLLNDSNWDMEGLDHAIRQALAEATKWGQTGVVTFLQELLKSRQGSSGSEIIPALLDARSYGHDLAWMNIMSRSVLALPFAGDLDSTWRYLEVRIRTVLSERGTTSLDMNDVRHHPSMCGAHLLGEDIYQKLVDFLDAHLLQVAIQARTCSGHALVAFYAQEWVHYTAAAKYVDKTFSYLNRHFIRRELDEGRRSIFDIYHLHLRLWRKTLLTQIGDQVRESIFNIMDIQRQGEVIDNNLVRIFWESLVSLENEDDPKRLHFYNVSFQTPLLKSTKDFFEDQSKLFLAENGFTEYIKYARRQLYEEEQRAKLYLHESAKQPLLKTCEEALVRDHTALLQNGFVDLLNGCHYYEVQTIYGLLSRVPDTLRPLHTAFETYVRTMALSSITNMINGLDEVEPRSYVNAMFQIYRECKTLVSRALDNDPAFNRALSRACKEVFNHNPACGGSGRKAAELLATYADLVLKKAGTGREADDRDNILTRITTVLEFIEDKDVFQTFYSRKLGRRLRTRGTDYDQIENEMITKLRGPCGIGYTNSLQRMLRDIKVSKDLENGFKEYIKEDGNIELQKIGGSYHVLSQNSWPLLPPSNHFSPPMEIGEICTRFQSFYDQRYQGRKLTWLWKHCSGELQAKYASSRTPYRFQVSLYQMVILLLFNSSEMKTYQEIMDVTELKSEALNASLDIFLDAKVLCLGPEEDNTRRNYRPDMVLRLNKSFKSKKIRINLNIISKAEQKKDSIEGYKSIDIERSIITRATLVRIMKARKKLKYNELVVECITQLQSRFMLKDVMVKRAIDELMDNNYIDRADGDELVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q6A4</accession>
    <name>A0A3D8Q6A4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_12667</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q6A4"/>
    <dbReference type="OrthoDB" id="2094269at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="30"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW57217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="319" mass="35542" checksum="65F2D2B5AC44264C" modified="2019-01-16" version="1">MHGCDFAFAISPLPSTTPVSAAAVETKPAQLRILMLHGFTQSGPSFRVKTRKLAHLIKHSLPPAILGQYPGGIRFLYPTGPLNLIPADQTGDEPSHQEESDNWAWWRTLDTTSHYRELDSTFQRLTDYISLHGPVDGVIGFSQGAALAAMFASWCESSVVPGRAFSLATQEVPLTIAAPQGPLKFAVCFAGFRGTEQYYPGFYEPKIETPIMHVMGKLDNMVTEEHTMDLFDACANGVLMTHDGGHYVPLQYNVLLPVVAFVESMFREPYYIKDVDGFMRGRKVDAVLEIPKPKIKRRSSLKSVVLCSKHMRVIRRRIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q6H5</accession>
    <name>A0A3D8Q6H5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_12698</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q6H5"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF461">
        <property type="entry name" value="AMINO ACID TRANSPORTER TRANSMEMBRANE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="526"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="8">
        <location>
            <begin position="122"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="71"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW57248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="575" mass="62459" checksum="4C9BA1209F76A813" modified="2019-01-16" version="1">MDVKQALTPADIQLDEKGHGTVETFHVGETPNKGILLEEYLYWASITRAQEAQYEDEGDAFRLFRGKLTKKSPAENNTPTPVEISNGTDEKNGHAVDGVSTSPTTAVSDEEWAEASRGIRTATWSAVFYLVTADIMGPSSAPWAIAQLGYGPGISLYVIFGIVAGTGWLLWQMFLKLDSEKYPLKTYGDLAFRVFGSKSRHFVNVLQSIEILSNVGVILLGNSQGLSQVVIGKVCFSVLCLIWAIAGMVIGQIRTLQKLSYLTSLNLWMTILTLCMTMGIISHSAPSYATALASNGVAEGPVITTGGVPPGSTFNSQIVGLMQAVYSYGGAVLFLEFMSEMKRPWDFWKSLMAAQVVILTVYLTFGIFVYTYQGQFAINPAGQGISNFTWLCVINVIGMVAGIISGALYGNIGIKVIYQTVIKDAFNGPELNSSRGKLIWAGMVPLYWSLAFVIASAIPQFSNIQGFIGALCILQFSYTFPPLLKLGFDIQAHAILPGETFDPVTRQVNRMDKGFTRWARGMKHQWYIKLALLLFVLASASTAILGMYSSTLAIIAGFKAYHAASAFGCVSPVIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q7D2</accession>
    <name>A0A3D8Q7D2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_12512</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q7D2"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF155">
        <property type="entry name" value="EFFLUX PUMP AFOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="171"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="473"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="81"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="20"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="53"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW57711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="523" mass="55961" checksum="DDBACDF1499FA86A" modified="2019-01-16" version="1">MPVNSLSTSASIVVEEGVCDQQSKDLVPSSAPESLLMEPELQLRSKTQAETGGEEKEKEAPTEKTTEEQLPNISGLKRALIIVPITLVYFLVMLDSSIISTAIPQITNEFNSLLDIGWYASAYQLASSAFVPLAGKIYTFFSIKWSFLAFFAIFELGSTLCGAAQSSPMFIVGRAIAGLGASGLMNGILTILAAIIPPHKLPRVLGLNISLGQAGMACGPLVGGALTEYATWRWCFYINLPVGALVGVLLFGLDIPEIKPKPPVREVLRTAVSTMDLFGLVLLWPAAIMFFLALQWGGNQYRWDSSVVIGLFVGAAVTSAAFLWWEHRYGDNALLPFSMLRMRVIYSASATMFFFLGGMLTSYYYLPIYFQAVKGDSPLMSGVHILPTILSQVIVTVSTGALTQKLGYYLPNVLAGTALTTIGYGLYSTLRPVTLVGKWVGYQIIGGAGNGAASSGAYIAIQNTVPRASIPTAMAIVLLCQNLGSAVFLTVAQSIFSNSLHSYIKKDAPGVNADAILAGGARM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q7H7</accession>
    <name>A0A3D8Q7H7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q7H7"/>
    <dbReference type="OrthoDB" id="406634at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW57773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="130" mass="14220" checksum="C81C9428A0791FD9" modified="2019-01-16" version="1">MAISQSNGSSSIDLSLHVENAYFAFRPGFLLLYCLLQDAKKEAHKSVVDIRSALAKLDLHEISELRTLVVVVPSPPPHHGAMGGERWSDARPLFADLRVDPHFLCHFPGMKALFNGPESPRQVQGSCASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q976</accession>
    <name>A0A3D8Q976_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_12325</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q976"/>
    <dbReference type="OrthoDB" id="5213892at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF20">
        <property type="entry name" value="PRO1A C6 ZINK-FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW58395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="302" mass="33898" checksum="4F97E2C68410BD06" modified="2019-01-16" version="1">MAIAIRMFVKAKNDRLRSSRALEAKRRQRFQSQETANSFETNIPVTKSMKYQQDRLLQSLIAVSNPLDAPGLQAISLSLENQDNQGLPPGPVGCEHWIKVLIDDIYTLGIKKSEYSKLDEIGGFQGEASEIQCWVEDGIRVAHQKCVELTAIAPDRSIQPAEAAAYLRRIEVSLVTCLFAHAALLYLHITLHGADAVARPTTKKLVFELIFTFRFIPEHTLLPSLVWPLCIAGCMATTVSERQFFRGTVASSGIDSRSSCMIWRALEIMEICWYRPKSDGMQPGDLAWIEALEELRNSVVIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QEN9</accession>
    <name>A0A3D8QEN9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_11879</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QEN9"/>
    <dbReference type="OrthoDB" id="10600789at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW60273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="613" mass="62103" checksum="D062CC85B37D77E3" modified="2019-01-16" version="1">MRVIRTINFKTSRACYASSLLAIPLTSTQFDKQSEARECCDSCHLIFFQNTATLNPAPPSGHWLARVIDRDSRKFDALDFQDVEEIGWKRQRCSTAKTDAIRVDTDGLTVRKNLIENPGAEINRASNKSLGVGKVEDRLETIIDIAAASQGVRNVIDGNVIDGGLAVTLLVAKVGIDTENGRVVVGSGKEKGSVVGNDICSDVGNDRGSVVGIEKGSVVGTEKGRVVGIENGSVVGTDGLLVGIEKGSVVGIEKGSVVGTEKGSVVGIENGSVVGTDGLLVGIEKGSVVGTEKGSVVGIEKGSVVGIEKGSVVGTDGLLVGIEKGSVVGTEKGSVVGIEKGSVVGTDGLLVGIEKGSVVGNVKGNVVGIEKGNVVGIEKGSVVGIEKGSVVGTDGLLVGIEKGSVVGNVKGNVVGNEKGSVVGIEKGSVVGTDGLLVGIEKGSVVGNVKGNVSESDVGNDSLLVGSDSLLVGSESESDVGSDSLLVGSESLLVGSESLLVGSDSLLVGSESESDGVLVGLVKKVGKDTVKDGSVGSTGLVEGSENGRLNGLVAIDVLDVEALDADLVETVDDLDADVLDDDLVGTVDDLDVDVPDGDPVETVDVLDKDELVGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QEY7</accession>
    <name>A0A3D8QEY7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">40S ribosomal protein S18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_11590</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW59984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QEY7"/>
    <dbReference type="OrthoDB" id="1702480at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.910.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_uS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003140">
        <property type="entry name" value="PRK04053.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW59984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="156" mass="17793" checksum="29D6FD3804A21B08" modified="2019-01-16" version="1">MSLVSGEKSNFQYILRLLNTNVDGKVKVMYALTKIKGVGRRYSNLVCKKADVDLNKRAGELTSEELERIVTIIQNPTQYKIPSWFLNRQRDIVDGKDSQVLANGVDSKLRDDLERLKKIRAHRGLRHYWGLRVRGQHSKTTGRRGRTVGVSKKKGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QI69</accession>
    <name>A0A3D8QI69_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNI-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_11280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QI69"/>
    <dbReference type="OrthoDB" id="9994419at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW61388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="52864" checksum="67F973610E816D81" modified="2019-01-16" version="1">MSSSIYQSKMAAVHVEDISHIRERAPLEKLPAEILRLIKLTGLGAESLAENTNPYTDIQHDLITCLLTSQTLKDTALPLVYRYVKFSKASTFQKFLVQITKYPELGRHVQSLDLSELGTSQAIATADLLQCLNLTPLLRSFLAFPELELSSQVLQTLFCSLPQLQTLDLRSCNSQESASAFESLFANADLAISTSITELNLSNCSGFPENALQRVLSQLPKLQILDVSRTTVDGEALQSIPASARLTHLNVQHCTQLRGRAVARFIASHPSVQSSLVSFNAETKATLEDAVLDEEDVSKLLASIPKTVKILNLKHSIMTPDHLPLLQALSNQLDELSVGSDLRLEDIESLFLTPTTSAPALSPAESPSDIRPEAVKANSDPVLKSMAQAVAICNVRQRLLRIDVPDTPLWSLKSIDISGMHIFQQRKILTSLLLGDHSLPLTRIAIGEEVYLMCKDLKRVCAAVGWRVEWDGRACEILRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QIC6</accession>
    <name>A0A3D8QIC6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_11373</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QIC6"/>
    <dbReference type="OrthoDB" id="3511549at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02210">
        <property type="entry name" value="cupin_BLR2406-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052535">
        <property type="entry name" value="Bacilysin_H2HPP_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40112">
        <property type="entry name" value="H2HPP ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40112:SF1">
        <property type="entry name" value="H2HPP ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="2">
        <location>
            <begin position="62"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW61481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="191" mass="20994" checksum="435A64ACD27D880C" modified="2019-01-16" version="1">MADLPVVAPAPASSSIDQWKHDGVQVISGDNLDTNTAQTPGMNRAAAITLARAGAKKLWAGTVTIHPNAKTGAHHHGHLESVIYVVKGKARMRWGERLEFTAEAGPGDFIFVPPYVPHQEINALEDESLECVLVRSDGEAVAVNLPDLKPVEEPENVKWIDPTHANLPDHPHHHHHDQGHEHDHNHDHDHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QIS8</accession>
    <name>A0A3D8QIS8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DAGKc domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_11510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QIS8"/>
    <dbReference type="OrthoDB" id="3853857at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001727">
        <property type="term" value="F:lipid kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046512">
        <property type="term" value="P:sphingosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF108">
        <property type="entry name" value="DAGKC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DAGKc" evidence="2">
        <location>
            <begin position="122"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW61618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="499" mass="53515" checksum="33AEBCFC60E3CA94" modified="2019-01-16" version="1">MESSRPVASASPDTTYPASDSDSDSNATSVYDIAPTSLKYSDGELSWASADSSSHMLRLKDEEIAVVTAKAAGGYRVLYIPPPEKSVDKQPFELRSTSLTHLPGPFLDAHLFKTLPTWLDPADGKNIHVLVSTLSGTGLAPAFYDAILLPLLTAVGLSSSSYTTIKTESADSVKDFAKSTLLAGANAGQEQTVLMLSGDGGMVDTINGLLEDELRSSGYTKPVLAQLPLGTGNALFHSLHKSPNPSIASPYIQGLRTLLHGIPKSLPNFSAEFSSGTRVLSNEGQTASPIPKSTLYGAVVASYGLHATLVADSDTTEYRKHGRDRFGIAANNLLFPEGPEGKAFPHAYRAQVTLLRDQDEIKVPRKTHGYVLATLVSNLEKGFTISPDSEPLDSQLRVVHFGATSGLQAMEVMKAAYGNGSHIGMEWQGEDGVEEEGKTMKLGYDAVDGVKIEFQEPGEDWKWRRCCVDGLIVGVEEGGWMVVRKIPQGRECVDVVIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QKY0</accession>
    <name>A0A3D8QKY0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_10788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QKY0"/>
    <dbReference type="OrthoDB" id="3540210at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="564"/>
            <end position="591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW62486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="773" mass="85525" checksum="0D4C5CA56486CE01" modified="2019-01-16" version="1">MDSNIYLGVWTNYSNGTVLGATLTTTREKGFLLASFTGFVIAFVGSRFWNIICLILHRCYSTSESRDTIHHQRQVILRNSSSPDSGLVSLISLLWAWRKSGTKTKPYSRICPAILWAIGCIAMFTAATAFSSQISSSAGIEVLLNGNKCGIMTLPQDNLSITTEPETILAKRINDAANYAKQCYSTNSSGLLGCDKFVVQTLPTVIWDNNTACPFKDGICKSNNSNLLLDTGFIDSHDHLGINAPENERFAWRYSMHCGPLVTQGFSEQFVFQNTTWVAYKYGGHTNSTSNYTITMDYTIEIEGVDAQYAQVSRFSNQPNYGLLAIDYQTSNGYPYPSASSFMPIPQLLRPDGDGTIVFLSGDGVLFSEPMNGDWYHATEAFMEYKLAESTQAQTEGTMMYRLTEAASPLGCVEQWQWCNSAYARSPAESGCGPLASFTDSLYRAAPYFNLTGDEVLNVARSNSSLPASQRFVWQALLQSYSNTNIGSILTTLGAKSLASQSLMNSGSQLPLPDNQWQLDVTNWWNIILALLQLTYVDTGQGVTSSELLEFQKIRSTSYTSFNLFALLLIYIGGGLIVVTSFSLEPILACLQRRRKHKEYSYLEWSTNSTLQLHRLTQEELQIGTWSGCTDKIPITKADEILGSLDISDIKHPVLTRTASATTEKIAPTLHAAKESNKYQYKNQTGHNEILAGSNASSETRPVKNVDRQSLLASDTRQINEAETQLTRQNQSSQETGNDNVAVGANTRLHISDEAPWSQVSVDVSDEDHYPRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLV6</accession>
    <name>A0A3D8QLV6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_11049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLV6"/>
    <dbReference type="OrthoDB" id="3358048at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW62747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="213" mass="23313" checksum="C54B68D94C89B878" modified="2019-01-16" version="1">MDQTTSRLRKTFHYPDDNDSDDSLPEALDEEEQDTLIRTLQQQNQTRNKQYTIALLSISLLSTLPYLASLFQRTTALLSILSITSLLSTAYLLSIFPAETTGLQILDDLIAPPQKNLKAYQNYQSTRTPPLLGNGLGAGGGGPIGELLPLLNLGLCTVLVIAGRVLRARVEMWNGFGWLPGFVYAVVLIAKAVMGSVDPEKELGELRYGFKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLW0</accession>
    <name>A0A3D8QLW0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_11115</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLW0"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="4"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW62813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="530" mass="58171" checksum="25A46A8EF5291F29" modified="2019-01-16" version="1">MARPTVALRQGTFVGTDLKRDFPQTLDQFLGIPYGLSTAGERRFKPPVRVASSTTTFDASQFGQRCPSGIPDGVPMGEDCLNANIYRPKQRDTSQKLPVVIHVHGGSFNFRSGHARDIASLVAWSSEPMLGITFNYRLGAFGFLPLDGSLNLGLKDQALLLEWVQENVAAFGGDPDNVTLMGVSAGAHSIGHHIMHPKTKPLFHKAIVESGATTARAVYPYTCHLHKTQLQIFLEHAGLSSVPPCDLFKALQSLSFSTIKSASENTFIHFMESVKWPFQPVIDGDGGIIPVAPIKAWKDGNFSRIPILTGFNTNEGAAFVPQDASSPTAFLDFFRTLLPSLREEDLRELEQVYPDPTTSCNKMYKETRPGLGSQFFRMEQAYGHFAYIAPVRQTADFACKNSTLDNPVYLYHFAVNSSVNGGANHGDHTEFATYSQRSSSSIESISKSMHAYWTSFIVSGNPNSVAGNCGARPEWPIYSGARTGQKMVFGEGNDILAGGKNEGVAAKVEADSWAADECEYWWNRTELFEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QPT4</accession>
    <name>A0A3D8QPT4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_10335</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW63833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QPT4"/>
    <dbReference type="OrthoDB" id="63070at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000557">
        <property type="entry name" value="WD repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051859">
        <property type="entry name" value="DCAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19847:SF7">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="407"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="454"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW63833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="704" mass="80510" checksum="6BF359C5228CE011" modified="2019-01-16" version="1">MDPLTGHPAIPEEEDDEGDDLAYDRPTQDNDDEDEDEDEDEEGSERDQVAFIERLLATQEEDDDDEDDDDDDEADLDGGEPRYTEIQVQFRGDDDGGEPDQERSEPPFLFTFIHIVLLIFRLAVARQRRQVMRLLQHTAIGRLFQFSADDDDDDDEDYEDDDDRIGHMWRRRRRRARPDPDRFPKVPSDVGTELMNSGTFGVNDVISNNAASEDGLRTRKRLARRVLDRELAVDSEYRQKVNRKIMAQGMIPTCTDMVIHYDQPVYSGQFSDDGNFFFSVNKDFRVRMYDTSNPYKWRYYKTVEYPFGQWTLTDASLSPDNKYLAYTSIRSTVCLAPTDPNDMGDPYNLDLADRGTGVGNNGRARLGGSFGIWSIRFSGDGRNLVAGTTGGSIVVYDIESRRTTSRIIGHEEDVNAVCFADKSSPHILYSGSDDTTLKVWDTRSMGDSREAGAFVGHIEGLTYIDSKGDGRYILSNGKDQSMKLWDLRMVMSPSDFTALRPSRRIESHFDYRWGTYDDDDWYAHPNDNSVVTFRGGHRILRTLIRCHFSPPDSTNSRYVYTGSEDGKVYIYNLDATLAGIVDVYGATKDTRPMHDFMRGYDDDEDITHSRWRTCVRDASWHPNAPIIAGKSNEELSSAWSGYGMSTGTCTVHSWNDGAKEDEAEPKMGLRVNQKLERDPNFYEDESRRRMTPSLRAQALRRFMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQ87</accession>
    <name>A0A3D8QQ87_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">T-complex protein 1 subunit zeta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCT-zeta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_10485</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW63983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQ87"/>
    <dbReference type="OrthoDB" id="10052040at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03342">
        <property type="entry name" value="TCP1_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000058">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000004">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012722">
        <property type="entry name" value="Chap_CCT_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02347">
        <property type="entry name" value="chap_CCT_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW63983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="559" mass="61269" checksum="B5E7F2668C6E1573" modified="2019-01-16" version="1">MSAAQLLNPKAESRRRGEALRVNINAGEGLQDVLKSNLGPLGTIKMLVDGAGAVRNPRILSNSFANRFQPQIKLTKDGNVLLREMQIQNPTAVMIARAATAQDDICGDGTTSVVLLVGELLKQADRYISEGLHPRIITDGYEIAKAESLKFLDSFKLEKEVDRELLLSVARTSLSTKLNATLANKLTPDIVDAVLAIYNAPNKPDLHMVEIMKMQHRTASETQLIRGLALDHGARHPDMPKRVENAFILSLNVSLEYEKSEINSGFYYSSAEQRDKLVESERRFVDEKLRKIVELKKEVCGNDPKKGFVIINQKGIDPLSLDVLVKNGIFALRRAKRRNMERLQLICGGTAQNSVDDLTPNVLGWAGLVYEHQLGEEKYTFIEDVKEPKSVTLLIKGPNQHTITQITDAVRDGLRSVYNMIVDKSVVPGAGAFQVACAAHLNSEAFRKTVKGKAKWGVQAFADALLIIPKTLAANAGHDIQDALAALQDEHADGAIVGLDLITGEPMDPVLEGVYDSFRVLRNCIASSSGIASNLLLCDELLKARQMGRQANPGPGMDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQL9</accession>
    <name>A0A3D8QQL9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BP5796_10604</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="11"/>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQL9"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.50.20:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1910:FF:000004">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="14">
        <location>
            <begin position="26"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="12">
        <location>
            <begin position="251"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="13">
        <location>
            <begin position="542"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="327"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDW64102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="888" mass="99323" checksum="7CF3B0644CDA21FD" modified="2019-01-16" version="1">MHGDGGVEGSGMDVTQGREILPANVVPKHYHLTLEPDFEKFTFDGTVIIDLDVVEETTSISLNTLELDIHSTKIISGSQTISSNPELTYNESTQTTKVAFEKTISPGSKAQLEIKFTGQLNDKMAGFYRSTYKNQDGSEGILATTQMEPTDARRAFPCFDEPALKAEFTITLIADKKLTCLSNMDVASESEIKSAMSGDMKKAVTFNKSPLMSTYLLAFIVGELNYIETDKFRLPVRVYAPPSSDIEHGRFSLELAARTLEFYEKTFDSKFPLPKMDMVAIPDFSAGAMENWGLITYRVVDLLFDEKTSGASTKERVAEVVQHELAHQWFGNLVTMDFWDGLWLNEGFATWMSWYSCNVFYPEWKVWESYVTDNLQSALSLDSLRSSHPIEVPVKRADEVNQIFDAISYSKGSCVLRMISKFLGEDVFMEGIRQYLKKHAYGNTQTGDLWAALSTASGKDVEKVMDIWTKHVGYPVIAVTENEGDKSIHLKQNRFLRTADVKPEEDEVLYPVFLGLRTKDGINEELVLSERESDFKVKDLDFFKLNADHSGIYRTSYTPERLEKLGKSAKEGLLSVEDRAGMIADAGALAASGYQKTSGVLNLLKGFDSESNFVVWNEILSRLGSIQSAWVFEDQSVKDGLEAFQRGLISDKAHKAGWEFKDSDDHIEQQFKAMLFGSAGLSGDKMIIKAAQDMFAKFAKGDKSAIHPNIRGSVFAIALKYGGKAEYDTILETYRTSKNSDEKNTALRSLGRAKDPELIKRTLTLPFGGEVKEQDIYLPIASLRTHPEGIEAVYDWMTSNWEELTRRLPAGLSMLGTMVSICTSSFTSEAALQKIEKFFADRSTKGFDKGLAQSLDAIRAKSAWLSRDREDVKSWVEANQGKSIKSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQX8</accession>
    <name>A0A3D8QQX8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_10697</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQX8"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03751">
        <property type="entry name" value="proteasome_alpha_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000044">
        <property type="entry name" value="Probable proteasome subunit alpha type-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1 2 3" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="5">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW64195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="294" mass="31789" checksum="42D05EF57C7F126A" modified="2019-01-16" version="1">MTSIGTGYDLSNSVFSPDGRNFQVEYAVKAVENGGTSIGIRCKDGVVLAVEKVITSKLLKPGANKRIATIDRHMGAVSSGLVPDGRHFVSRAREEASSWRKVYKSPISTSDLASRMGGYLQAYTLYSSVRPFGITAIVAGWDSEVETPVDAQVGNGPSIGSGGKAEGKKYGGPGLYMIEPSGIYWGYYGAATGKGRQTAKAELEKLDLAAGTLSLEDGVKEAARIIYVAHDDNKDKEFELEMTWISNLEGPTKGRHQEVPKELLEEAERLAKKALEGDDDDEETTDKPEDKMEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQZ4</accession>
    <name>A0A3D8QQZ4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter-36</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_10735</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQZ4"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17316">
        <property type="entry name" value="MFS_SV2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000171">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511">
        <property type="entry name" value="SYNAPTIC VESICLE GLYCOPROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23511:SF12">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01740)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="473"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="55"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW64233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="523" mass="56999" checksum="684D28D6218DB6E4" modified="2019-01-16" version="1">MAATDRVDVSKGATSRQRTNTKSSHGDTARDEDAVLPRGTIDPVYEAKARVLNHAIQEIGMGWYQWQLFTVVGFGWANDNLWPIVTSLIFTPIANEFLPSRPPLLSLAQNIGLLAGAMFWGFGCDIFGRRWAFNLTLGVTGVFGLIAAASPNFAAIGIFAALWSFGVGGNLPVDSAVFLEFLPGSHQYLLTVLSMDWAIAQVVAILIAWPLLGNLTCQEDTTCTRAENRGWRYFVIVMGTISMLEFIVRFCYFTVYESPKFLMGKGRDEEAVRIVHEVARRNGKESRLSLADLQACDPDGTFTQVNTGAAIKNRLSQLNLTHVRSLFNTRKLAWSTALIMLVWAFIGLGYPLYNAFLPYIQATRGAKFGDGSTYLTYRNSLIIAVLGIPGALIGAVLVEVPRLGRRGTLAISTILTGVFLYCSTTALTSSELLGWNCAFNFCSNVMYAVLYAYTPEIFPTKDRGTGNALTASANRVFGIMAPIIAMFANLETAAPVYTSGALFITAGILVLLLPFESQGSASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QR78</accession>
    <name>A0A3D8QR78_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Quinone reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_10652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QR78"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF1">
        <property type="entry name" value="OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="18"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW64150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="387" mass="41605" checksum="35B90C9E36591E90" modified="2019-01-16" version="1">MATPSDLSNQQWTSNLTGTSSLSLRTVPLSLPSCLGPNEVLVKIHSVSLNFKDAETVNGQFNHHKSISLPEEIIPCSDAAGSIFRIGAKVTRWQVGDRVMSVGVPDFWSGVLTEELLRGGIGASGKGVLCQYRVFKDYALVPTPAYMSDDEACTLQVAGTTAWMAMNGLRPLGHPGGQRETVLLQGTGGVSMQGLLIAKASGAEGMCSPLLSLPACIQAKKPPTLTRRIAKVIITSSSDRKLAQAQALGADHVINYKTTPAWDEEILRLTHGRGVDLIFENGGALTTVKSFNALKMGGTIVGIGYVSGKIDPPDERVNINVMVIKKNATYKGLINGPRERLDEMLAFYEKHQLRPVIDRVFAFEDAKAAFAYLESGGHFGKIIIKVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QRB4</accession>
    <name>A0A3D8QRB4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Kinetochore protein Sos7 coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_10536</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QRB4"/>
    <dbReference type="OrthoDB" id="18959at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037475">
        <property type="entry name" value="Sos7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048781">
        <property type="entry name" value="Sos7_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37329:SF1">
        <property type="entry name" value="KINETOCHORE PROTEIN SOS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20882">
        <property type="entry name" value="Sos7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Sos7 coiled-coil" evidence="2">
        <location>
            <begin position="72"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW64034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="240" mass="26590" checksum="25449AFD82C329AB" modified="2019-01-16" version="1">MAQDDLNTKAADVLERLQQNQQAQELSIIKLGALVDDKSRDETGKRSSDVSPEIQSVLTPASLESDLAHYKELFSKLRFSYLEQVTKERFIRSIVDDPPLMVEHQENVELEEALAVTKAELKELKTEVADLVVELGKRGRELYRGSGEQHRAAKGISGTWTKPESQYALRENVEFGGRTREAESRTGQAARAIAVFGAEKDTRAGKTAVGAAAFGGQEARNDCFSQGSEEEEGGSFRRDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QTU8</accession>
    <name>A0A3D8QTU8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_09911</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QTU8"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15535">
        <property type="entry name" value="PHD1_Rco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15534">
        <property type="entry name" value="PHD2_PHF12_Rco1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052819">
        <property type="entry name" value="Chromatin_regulatory_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47636:SF1">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATORY PROTEIN RCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="770"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="77"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="415"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="518"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="433"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="491"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="531"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="559"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="629"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="705"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW65219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1172" mass="126480" checksum="D02A6ADFFBB6A610" modified="2019-01-16" version="1">MGTSRPTRSRFSSPFLPANTTSASVSTVSGSAERSRDKEKERPKTFMDRWVEPPLPLPRPSFADAGIARHGVVANMAPLGTRPSSKIIKSARAGSADSARYSPVAGRKAAGSREAESTPEPSRLSVVTEPEAADSVSAKTESVEIESTLPSTPAQQTSPLDIGSPTPQPDPVSASPPAESNSTTKEVPSAGSGRSAFTINSPQSITSPRSVAALLLAANPPRVHQSPYAPLPPQGYRPTTAQGPYGSPYGPSKNCGERQVTVGEVDRVVEAAVNVAVQQRRWPTAFALRTLYDENRNNARIVRLFDSIYIQTATEEERKEFATLMKFKKRDGKKDKKADYYFNGDGSDFALPIAQPQFQQVNFTEAATPIPSQISPAQTSCHLQPYLTPYANAQQSQQPDLPSTAKVTQQIEESAVKATNEDKSTMAASESTANKDDAMEHPNKQHKGNDFQPSGMEIDKAVNGNGSGNGESSGLVTTPEPSEQTRERSDSVASSTSSLSSLDEGILVAGEAFMSPVRDSHATPRANTNDDAEHASHTQSHDQPISSSKALGPKTHTFSSATPLPPSSSLSNNPSSPPDSLNNEMPSVVAPSSPAQQLPFFKPKKEFNKVTGSAYDADDISSRRKRKAKDVTERSVDPQPSFERHLLATAAEVESSDGGDSAIALPPAKRPRVRLLNTSRRSNYDSEAESSPTLLEFRPDLVPASRSTSRAGTPINSGRPSRREKKSGTGLRVKSSPMKKKGGTAGIPRAGGERSPIANGALPHNQEDNDDYCSACGGNGDLVCCDGCVRSFHFKCVDPPMNQDALPDEWFCYSCLARRDGRLPAADGVFGILQSFMERKNPTSFHLKKDIREYFEGVKTGADGEYEDAAPLEKPKNRAGYEEAPDYFKLKDAKGNSILCHLCHTSASPPNRMIIPCGFCELSWHLDCLDPPLAKEPPLAKKWRCPAHVDDLLADTPDTLGPAHRFRKIKGASVITPAFSRGTKNNGHIEIENTPSDDEDGGFYERREYGRVYKLPERGVKLDFISQVKRKCHTPGYDPRYPYPSFGRLQGSQQQAAGPVRRSVTEQQAALNLAYFASHLADPSQILIDTLLAHAPSAVVDLIAQGDTSNFEAGKISEQDQVALGAMANLIAKLQSGTLVQPKMATPPLDDGKDVKVEIGSQTHEDDAEMLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QU91</accession>
    <name>A0A3D8QU91_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DUF788-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_10108</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM208 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QU91"/>
    <dbReference type="OrthoDB" id="10012212at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008506">
        <property type="entry name" value="SND2/TMEM208"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505:SF7">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05620">
        <property type="entry name" value="TMEM208_SND2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="43"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW65416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="161" mass="17891" checksum="959FCF7037D67762" modified="2019-01-16" version="1">MAQKAKKDRAKSNIATLNNLHVGSLVANVVFLLFSLLIRKRSLLVWFVLSLPALISQFILERSGRPSYDPSTKALKASGEDLAAPGLTEYMFDIIWVTWASLFVVILFGNWGWLLWTAVPIYGAYKGYGLLGMAKGLMGGGQGQQMPEEQMPMNRKQRRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUI1</accession>
    <name>A0A3D8QUI1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_10104</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUI1"/>
    <dbReference type="OrthoDB" id="10327244at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="405"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="3">
        <location>
            <begin position="284"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="59"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW65412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="434" mass="48759" checksum="6CE2C560BA8B6E0C" modified="2019-01-16" version="1">MPRPQRPADLESQISQILNDGDSYHSSSSRLPLSLLHNLRVHFGLSGAHSPEAEDEAYTTNSTNLSSVTGSSSSENTLTAPTTNCTTAPITPPKRRQEANLGEKQGGWPLLDPANCCKSAERNVGRVDTREDGIVEETRGRSILSGENNGDVDFERFRASYHPQAGLSDSWLRDLFLDDVYWSLERLQMEYVIMGSDNEKYWSLQDDPRRRDLIHQQLCRLIKTMKNYKTYRTSPISKDGLRILPGHFFPTPSHIQKLAMIEAARKARIPSETPYIKQLVDDVSDAYITPFIRDHLHGVLTLAPQDGPMPPSPTLPPRLFKHGSKFLTYYFASPKILFARTIFYRSRTKRLERLCISVFTLVMLFLPTTTLILYPGALTMMIVIPLSVTIVSIVMAIGLPDNNGVGVFVITSAYFACLAFFLADLNSREHGTDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QVP2</accession>
    <name>A0A3D8QVP2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HD/PDEase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_10276</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QVP2"/>
    <dbReference type="OrthoDB" id="2378324at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35569">
        <property type="entry name" value="CYANAMIDE HYDRATASE DDI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35569:SF1">
        <property type="entry name" value="CYANAMIDE HYDRATASE DDI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW65584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="26523" checksum="76FFCCA82A20FE69" modified="2019-01-16" version="1">MCQFTNDQQEATSTPEQTAEVIRAKYVPDSKLCQTAFTYAAQHLGPSILHHSIRVYLYTQALSSKLEKPSSKNLTTMLFIAAMFHDIGTHDAFNGPGRFEVCGADAAVTFLRANAHDHDMTEAELQEIWIGIACHTSPEIAERISAFSKLIRLAVLTDFDRPGLRREFQVEELTAEIETSLPRLAIEKILGDAVVRQIMGKKEGADRLRKGPNNSWPGSLLRGELEKEPGYAGVNKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYC6</accession>
    <name>A0A3D8QYC6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial adapter protein MCP1 transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_09538</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYC6"/>
    <dbReference type="OrthoDB" id="10259513at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039960">
        <property type="entry name" value="MCP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012472">
        <property type="entry name" value="MCP1_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38409">
        <property type="entry name" value="MDM10-COMPLEMENTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38409:SF1">
        <property type="entry name" value="MITOCHONDRIAL ADAPTER PROTEIN MCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07950">
        <property type="entry name" value="MCP1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Mitochondrial adapter protein MCP1 transmembrane" evidence="3">
        <location>
            <begin position="185"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW66789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="310" mass="34116" checksum="B638780F339C5FC5" modified="2019-01-16" version="1">MGDRNPRAMASQETLASLQQIDPSPIDSPYYEDEKPFPDPDSASPPAQGALPRSSTLGLSGGGHGAVYYLTRLQRYSSYVFAAYTTAHITNTALIPLLTRSVPVSENYLLLTRPYYQSFPFEHLLITLPLATHVLSGLALRIRRRNQNLARYGGGNLPIATRLQQRWRIWPPVSWESASGYMLVPLVGAHVFVNRLIPWWYEGGSSSVGLEFVSHGFAKHPFVAWTGYLALLGVGTGHIVWGAARWLGLTPVGKDKKAKRRWWAVNGAWAVTAAVWIMGGLGVVGRGGKAEGWIAKGFDELYAKIPFVDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYG1</accession>
    <name>A0A3D8QYG1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase-22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYG1"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF52">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="57"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW66807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="252" mass="27216" checksum="DCA63BFEE0AEAABC" modified="2019-01-16" version="1">MSSTRPVQSVTTAELYERWAKVYDTDGNILQAIDDVQLPALLQSAFSPFQAGNPAAVLELGCGTGRNTLKLLSPPYASKISKVTAVDLSASMLAVAQSRCRDLAQSPSRTPAVEFSQYDALQPTALPGFQNVDIILSTLVLEHLPLATFFTAVKSLLKPGGTLVLTNMHSEMGARSQAGFVDPESGEKIRGLSFAHEIEQVLDFSKRLGFLPVGDVVERGIEEKDLGDGVVGERGRKWVGISVWFGLVLRLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYP7</accession>
    <name>A0A3D8QYP7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CCD97-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_09550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYP7"/>
    <dbReference type="OrthoDB" id="333176at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040233">
        <property type="entry name" value="CCD97-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018613">
        <property type="entry name" value="Ccdc97-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31840">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31840:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09747">
        <property type="entry name" value="CCD97-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCD97-like C-terminal" evidence="2">
        <location>
            <begin position="28"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW66801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="213" mass="24508" checksum="E27A19A12D910777" modified="2019-01-16" version="1">MPHKEESPLADQDVFEAEERAQRVRVKNRRKLYLDNHPSYFTNADLELQDPLLYDRCVRRFQSAAEREADGRSKGYSGVLEADLYRSEAKLAALAGSQSSELASQRPSSPNSTVPFVSYVRGENGQVLPEEEDEIPQSKEEGFERWKFVMTLRFLKGEDQDFDYKAVDENDVLDPIENQEKEEKWFDEEEPEWVSGEEEGKESLGGETGIQDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYY0</accession>
    <name>A0A3D8QYY0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYY0"/>
    <dbReference type="OrthoDB" id="5401193at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW66880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="424" mass="45280" checksum="7C46265DF86424DD" modified="2019-01-16" version="1">MSYYDNQQWTAASQNQWEGQTPPARSGASSVVPREDSMAFSTQLEEVDRAIDNLVKSGKMFNMPGRRESMPPAPAARDFSQQFGKPDSRPKRSTPNALQDPRMAGGAPRHHSVSDFGDARSYSQGSGLQNFYATQRHQPSRGTNEAEQVMQAKRRMAAQRERELRNYHQEQQYNRSVLAEISTFGGKTDRTMSPGSGMSEEERRELIARQRSALYGEGTSGFAENGQFEENGTPRPGTQGSGNQSATGIRGHSPLAFDHYNAQANPGQAENAATQDSQQAQAQGQQRSRANSTSSPSSNPTSSFSLFESANAHVQSSRTSTSSPGGSPPRNGANKGLPSAPGVAPIGTRPAQAPNPALNKRSTTPLPSPLSFGFAANSEESSGDKTGRTASAASNPNEGLGWGSKSAVWGAQKNSLGVQASVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R2D4</accession>
    <name>A0A3D8R2D4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_08860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R2D4"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="69"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW68203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="239" mass="26546" checksum="72794C64A9BA67BA" modified="2019-01-16" version="1">MVDQKESFWMMKRSEWPSDNDVPNFRETTSKFISKCEGISDKVLSCLSVALGFEEDYFRKGMGIDEEDSLTQLRLIHYMASENAAGTWRAGPHTDIGCLTLLFQRDGEDGLEICPGRESSHSYGIGDTFTPLPAQTGPIVVNIGDMLMAWSDDRLKANFHRVRAKDVGKSPDRYSIAYFNTGRKGAIMQGPGKKNPPITCGQWFNEATERQFGAMSKRRQEVALKEDGKTATATVSAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R342</accession>
    <name>A0A3D8R342_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein mS41</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_09120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R342"/>
    <dbReference type="OrthoDB" id="18595at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039603">
        <property type="entry name" value="Ribosomal_mS41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019083">
        <property type="entry name" value="SAM_Ribosomal_mS41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28235">
        <property type="entry name" value="PROTEIN FYV4, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28235:SF1">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09597">
        <property type="entry name" value="SAM_Ribosomal_mS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01238">
        <property type="entry name" value="IGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small ribosomal subunit protein mS41 SAM" evidence="6">
        <location>
            <begin position="49"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="200"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW68463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="226" mass="25244" checksum="BEB8409421521A51" modified="2019-01-16" version="1">MIVKPSHLRPIPSFLLPFAQSTSSIQARGLHHRVKASPVPPPTPFVPDPQTFLALIGRNLSQHASKIPTWRALFTLTSTQLRELGIDPPRSRRYLLRWREKFRKGQYGIGGDLQHVENGVAALRVAELPIPGRSALEKRKVVVNVPTQNQLGEIPLESLVPLKNLHIQGAHTIVGPHVLPAVGGRAAKIEVKEGLWEDRRGHKIDGGERRQAEVRAKRRGEEKRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R3S5</accession>
    <name>A0A3D8R3S5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_09121</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R3S5"/>
    <dbReference type="OrthoDB" id="5387389at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052635">
        <property type="entry name" value="Sec_Metab_Biosynth_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607:SF2">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39607">
        <property type="entry name" value="XANTHOCILLIN BIOSYNTHESIS CLUSTER TRANSCRIPTION FACTOR XANC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="2">
        <location>
            <begin position="52"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW68464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="179" mass="20310" checksum="C7F5486BF21EE3B4" modified="2019-01-16" version="1">MSSSRSSRHESSRHHSSSHSSSKSKSSSSASSSSKGKSKKDDWSEITDPEERRRVQNRIAQRKFRDKAKETKEREERDAQNQMHASRSYHTPDPRDMGTDDELSGLPWGSLSLRHVVSKGKAREESSRRGSYRDEDRSNSYESQNASYAGGDAYYEGDAPYYEETDQVYYDYGSGGSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R410</accession>
    <name>A0A3D8R410_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF6314 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_09211</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R410"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045632">
        <property type="entry name" value="DUF6314"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19834">
        <property type="entry name" value="DUF6314"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6314" evidence="5">
        <location>
            <begin position="582"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW68554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="743" mass="83024" checksum="D2E9D9A2D74D0C17" modified="2019-01-16" version="1">MTGKRVCIVGAGPSGLVAAKTLLHEHPGVFQCTIYEKSDRIGGLWPSSESDVDGMVHPDMCTNQSKHTVAFSDLAWDEAAPSFPKAWQVGQYLQKYLDMYLKPSSACEILTKWAVVKIDEPKSEDGKGATEGPESLWKVLVKNESSGETAVKYFDHVLIASGFFGKPKVLDTLGALAAPVSHSSHFRNIPSLLSASGKQTPQGTKIVVVGGQMSGVEVAASIAMQISSAVYSPIGQRALENAAKYTIHNVVQRPFWVMPLYFPENPVLETEDEDVKMNNPASPFLPLDLVMYNLAWKPEGPIKNTSGEISPEAAEMTNDFMNKYVGSDQSELGTNDLAMKGEIRSKQPFLACSDQYTEFIRSGEIVTHRGRVTEASPDGKSIVIENQGSKYQLDDVAAVVFATGFKASPSISYFSSSILEQLQFDADSSEFPLALNVHSTAHHAIPSLGFVGFYRSPYWGVMEMQARFLGKLWTNDEKVAKTLADDDTVENVLKLRKSDRLAQFPMGDYAYLMESFSECLGIQRLEEKAGRNGIVLPQRYLPQTASELSRKQRDAAYAIIRREFQQSREEAKFVARAVFRALQGIWKVERTLISQTPAHPTGTFSGKASFHPRDPSDNEGKYDLEYLYNEAGEFKIQNGPTFPASRRYAYRYQTSKDELSAWFIKPADNHTVDYLFHELSFHAPPDSQPNQGWMAKGKHLCEQDWYNVVYEFQFKGVALQAWTMEYDVKGPTKDYRIRSVYER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7Z3</accession>
    <name>A0A3D8R7Z3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW69954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7Z3"/>
    <dbReference type="OrthoDB" id="5154006at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="96"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW69954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="360" mass="40040" checksum="1043E7C18CD6D476" modified="2019-01-16" version="1">MASNNNSRKAKISLTNYVLGGPLVSMKPTGSKAKDEPEPDKEPHYSVKKLDGGRIQLIDKRTGEKQIFKAKPSSKSTGVNEDGKVKVILRVKNRNAEIAIAAPEKTQKAQSTKKEDVSKKETEEKKEERNPTKKKDPENTKTKKVEEAPKPAAAENETEEEVKMPGQWKAGDWTPELDATIMKLKSENKSWKDIAIEVSASKKDAQNRFKELQKAEEDKKKGKEGTTANEDSDGNAAPSEGTVKEKDKECRADPGKKEDSKAQKKDDKPDKSSPSGAAPEEPSTSQQDMAATSTVTPRGEKGLKPDEIWTKDDCAVLEMLKERYEAHKWQHMQAGFFNWTGRMVVASIIEKKFKDDEVAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8B1</accession>
    <name>A0A3D8R8B1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Adenosine kinase</fullName>
            <shortName evidence="11">AK</shortName>
            <ecNumber evidence="4 11">2.7.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Adenosine 5'-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_08680</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine + ATP = AMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20824"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.20" evidence="4 11"/>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8B1"/>
    <dbReference type="OrthoDB" id="432447at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004001">
        <property type="term" value="F:adenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01168">
        <property type="entry name" value="adenosine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000014">
        <property type="entry name" value="ADO1p Adenosine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001805">
        <property type="entry name" value="Adenokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769:SF3">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00989">
        <property type="entry name" value="ADENOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="12">
        <location>
            <begin position="27"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW70283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="335" mass="36249" checksum="283717948A6FBDA5" modified="2019-01-16" version="1">MAATKEYALLCLENPLLDIVANGNQELLDKYDLKPNDAILAEEKHLGIYEELLNNYSAQLIAGGGAQNTARGAQYMLKENSVVYLGGVGDDKYAAILHDAVKQAGLRAEYRVDKKEKTGRCGVVITGHNRSMCTDLGAANHYDLEHLKSPEVWKLVEGASHYFVGGYHLTVCPPAIQTLAEEAAKNNKVFVFSLSAPFICQFFKDPLDASAPYWDYVIGNETEALAYAESHGVETKDIKEIVKHLASLPKANGKRERVAIITQGTDPTIVSVGGKDVIEFPVHAIDKSLIVDTTGAGDAFAAGFLAGLVDNKSLEQSIDQGQWLAKLGIQQNGAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8W5</accession>
    <name>A0A3D8R8W5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08745</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8W5"/>
    <dbReference type="OrthoDB" id="3513892at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF1">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="49"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW70348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="290" mass="33813" checksum="5F86238FD04EC39C" modified="2019-01-16" version="1">MSRATNDLRALMLRYRLASVRINEAAVDIVTLGSVSAASESSLAPGNSFHLFNELPCELRIKIWNLAILPRFVRVTWNEKLNRFTSRTPRPALLYTSHEARENALKIYQLCFAQSPELAKIYFSYDIDTVYFDWESIVDPYSWAYNKASLRNRIATEELHKIQRMAMHGIDLVAHRQTDYGRFGILNHFRNLKCVLCVEHLANGKPQEDRDGAEHLEELLNLLDTLRTVLKKDLDWSDIMDLAEIERRRDVERLWRFDGKELHCSVSKARDVRGQPMGPNCPWIFLTYRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RC76</accession>
    <name>A0A3D8RC76_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_07687</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RC76"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055080">
        <property type="entry name" value="Gal80p-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051317">
        <property type="entry name" value="Gfo/Idh/MocA_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708:SF1">
        <property type="entry name" value="GALACTOSE_LACTOSE METABOLISM REGULATORY PROTEIN GAL80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22685">
        <property type="entry name" value="Gal80p_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="22"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Gal80p-like C-terminal" evidence="2">
        <location>
            <begin position="138"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW71653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="393" mass="43470" checksum="DF75E51F1C30BB24" modified="2019-01-16" version="1">MAPIRVGFQGLSADTPLCWANHAHLPYFKKTSDYQIVALCNSSRESGQRAAQLHQLDPHIKIYATPEALAADPDVDMVICSVNVGKHYDLIKPAILAGKLPVVEWPLASNLAQAEELTSLAREKGLKTLVILQGRLSPVTAKVRQLIADGRIGEVFSVNLDAVAGYHGEDPIGVGGMYLSDRKVGGNMATIHFGHAIDTFLSAVGQVSSFTSYIANKRPFTKVIDRAQTPPTVVHEAFPKDTPDQIMLQGRLVSGALISVHMRGGRNFPGAPGMEWRIYGSTGEIRVVCPGHFLHMGFPKDTPDKTTEKFTYPGDGEFFMDMKFEVHDFATGEVEAIEIDQDEWDDLRREAQNPARVYEAYRKGDMRYYATFEEALERQKFIDKIMEGLTEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCK1</accession>
    <name>A0A3D8RCK1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative 4-hydroxyacetophenone monooxygenase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_07682</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RCK1"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF8">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW71648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="628" mass="71476" checksum="AE6F44724017D73F" modified="2019-01-16" version="1">MTPSTMDDQIDGHSGLSPDTKTRHIVGNAFTSPTPATKGTCSDDSLLGPIALEEFEYPPMSTPYHILNQYHSKPTKLRVACVGAGASGLCVIYKMNKMLVPGSWELMVFEKNSSVGGTWFENTYPGVACDTPASLYSYSWDQKPDWDHYYAYGPEIRVYFEDFADKNDCRKFIQFNTKLVEARWDQERGSWSILVEDQTTKERRSDWCHVLVNAAGFLNNWQWPDIEGLHEFAGPRMHSAKWDWTVEYKDKTVGVIGNGSTGIQLVPALQKDVKHMAVFMRSPTWVAPPFGTSALETDIRKGKKIDKGNSQHKFTEAEKERFKNDPEYYLMFRKRLEAEFNSIIQAFIRDTPLGSAVRESIIQEMEMRLGQGPESEKLKELLIPKWAPGCRRISPGDGYLEALVQPNVQPVFGAIERITAEGLVTESGDLHKFDILVCATGFKPAFRPAFSLYNEKGVSLDEDWGEHVNLYLGLTAPRFPNYFTIAGPGSTWAAGSLLPSIEAGVEYSVKVMKKIQEENIRSIEVRQDALDDLFEHFDEFHKSTVYQDNCRSWYKDGKIKNRIYLWPGGTIHHVKTLKQPRYEDYKIKYRYGNRFAFLGNGEVKANTTADVEGLSTYVRRSDHDWDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RD13</accession>
    <name>A0A3D8RD13_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial import inner membrane translocase subunit TIM54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_07956</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIM54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RD13"/>
    <dbReference type="OrthoDB" id="5598305at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050187">
        <property type="entry name" value="Lipid_Phosphate_FormReg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021056">
        <property type="entry name" value="Mt_import_IM_translocase_Tim54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358:SF101">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12358">
        <property type="entry name" value="SPHINGOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11711">
        <property type="entry name" value="Tim54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="245"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW71922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="461" mass="51623" checksum="58AE831C3C205389" modified="2019-01-16" version="1">MADSISPPAENAGSASKPAAKPDTNAAKPTRPPNPIYKYMGLGENFRPKLPSRNWTIFLTITGSFAAAVIYDKREKKRAQRKWCKLVEHIAKEPLDPRSMPRKLTVFLEAPPSDGLRISQDHFKEYVKPILVASGLDWDFIQGRKEGDIRAELAEKIRTSRLPADLREEDAILNTRRQQGVKDFDGPNGDIVIGRHTWKEYVRGLHEGWLGPLTEPPRPEPAEVPVPEAQAPQQVPETLPGITVHSSPGQTDAPPVNTPAVPDEKPKKPSPFIKTSEYNEVSDLAHLPQEFDPSQPIAFPHILGFFNTPTRLYRFLLRRRLADSIGRDTAAIILSTYRPYTNTSISSELSPASPEAISEQDAAMITEEKEWHKSVHKHTDDEPERTWLEPMVLDPRIASRMRKAELTPEDEERARKIVVSEEEVEGWIKGGIRSGIRGGVSYLGLGKKSDEKTSGEDEILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RD17</accession>
    <name>A0A3D8RD17_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CoA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_07987</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RD17"/>
    <dbReference type="OrthoDB" id="1664372at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009361">
        <property type="term" value="C:succinate-CoA ligase complex (ADP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004776">
        <property type="term" value="F:succinate-CoA ligase (GDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000001">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000017">
        <property type="entry name" value="Succinyl-CoA synthetase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117">
        <property type="entry name" value="SUCCINYL-COA LIGASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11117:SF6">
        <property type="entry name" value="SYNTHETASE SUBUNIT ALPHA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01798">
        <property type="entry name" value="SCOASYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA-binding" evidence="3">
        <location>
            <begin position="5"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase/succinyl-CoA ligase C-terminal" evidence="2">
        <location>
            <begin position="136"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-citrate synthase/succinyl-CoA ligase C-terminal" evidence="2">
        <location>
            <begin position="500"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00549"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW71953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="625" mass="66590" checksum="EE8C20468F903F5E" modified="2019-01-16" version="1">MPQATSNAKESIAWGTNIVGGVTPNKDGEHLGLPLLPSVRRAMAELKPDVTGIYVAAHQASTAIADAIEAEVPLIVAVAEHIPIHDLLRIHSMLNSQSKCRLVGANSPGIISAIGKCRVGFQPLACFSPGRIGIVAKSGTLSYEAVASTTLEGLGQSLCIGMGGDVLAGTNFVDALKVFEQDEDTEAIILIGEIGGTAELDAAEWIKDYNRRSSNPKPITALVGGVNAAPGRVSGHAGAFISPGEPDALAKSKALADAGVVLVNHPAKFGSVMKTLLGQSVQAKAKPIRTGAAQSRGLHTTKRLRPSQVNQNNLALQTRTLHIREDFAFDLLREKGLDVSKYSGQGRQRLLAIAVDRINRSPCVIASLDTEGPQTDSKTGKFPFDYRNGINNEQILHIADHLKLAESAKASLPKLIHGLIDLYNQKEAFLLETKFVEQLGDLKITGARFGFDDAAFRSSKRQGDIHALRRLEDEDPSEAEAEKDGIVYIKLQGSGNIGTLVNGAGLAMNTVDALADAGGKAANFLDTGGKATSETVKRSFQVILQDKRVKVIFVNIFGGLTLGDMIANGVLLAFQELEMRLPVVVRIRGTNEVEGQKIIVESGLPLFAYQDFEEAAAKAIELAKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDK1</accession>
    <name>A0A3D8RDK1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_08136</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDK1"/>
    <dbReference type="OrthoDB" id="4781at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050546">
        <property type="entry name" value="Glycosyl_Hydrlase_16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963:SF22">
        <property type="entry name" value="GLYCOSIDASE CRH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10963">
        <property type="entry name" value="GLYCOSYL HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GH16" evidence="5">
        <location>
            <begin position="1"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="257"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW72102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="324" mass="33530" checksum="6B61F40C72BAEDDA" modified="2019-01-16" version="1">MAPGSVGTVLATSTYLWYGNVKATFKTSRGQGVVTAFILLSDVKDEIDYEFIGADLQTAQTNYYFQGITNYGNSGNISLSDTFDNYHTYEIDWTPDKITWSVDGKVGRTKNRADTWNATSNQWAFPQTPARVQLSIWPGGLATNAQGTIDWAGGAINWNSEDIQSHGYDYAMFQSVTVDCYNATKAPGTNTGVSYTYNNAAGTNDTVIDGDKPTVLKSLVGTGTNMSAGLLDGSASATAQTIPGLSGAGPGTDGHASESASSGASATGSSTSSGSSAACSGFCQGVSGSGSSSQSGAEMLNAQTRMLEGSVFAALVAIVAMIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIC3</accession>
    <name>A0A3D8RIC3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,3-beta-glucan synthase</fullName>
            <ecNumber evidence="3">2.4.1.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">1,3-beta-D-glucan-UDP glucosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_07235</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[(1-&gt;3)-beta-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-beta-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21476"/>
            <dbReference type="Rhea" id="RHEA-COMP:11146"/>
            <dbReference type="Rhea" id="RHEA-COMP:14303"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37671"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.34"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.34" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1880850at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000148">
        <property type="term" value="C:1,3-beta-D-glucan synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003843">
        <property type="term" value="F:1,3-beta-D-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006075">
        <property type="term" value="P:(1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051278">
        <property type="term" value="P:fungal-type cell wall polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026899">
        <property type="entry name" value="FKS1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056261">
        <property type="entry name" value="FKS1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003440">
        <property type="entry name" value="Glyco_trans_48_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741:SF48">
        <property type="entry name" value="1,3-BETA-GLUCAN SYNTHASE COMPONENT FKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12741">
        <property type="entry name" value="LYST-INTERACTING PROTEIN LIP5 DOPAMINE RESPONSIVE PROTEIN DRG-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14288">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23605">
        <property type="entry name" value="FKS1_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02364">
        <property type="entry name" value="Glucan_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01205">
        <property type="entry name" value="FKS1_dom1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="499"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="543"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="586"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="614"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="672"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="729"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1352"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1404"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1610"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1653"/>
            <end position="1676"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1696"/>
            <end position="1719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1790"/>
            <end position="1813"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1850"/>
            <end position="1874"/>
        </location>
    </feature>
    <feature type="domain" description="1,3-beta-glucan synthase component FKS1-like" evidence="13">
        <location>
            <begin position="353"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="101"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="156"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW73793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1932" mass="220134" checksum="9C423E79CB920810" modified="2019-01-16" version="1">MSGHPQGHYDDGYDHHQPANTDSYYQDEHNQQYYDNQGGYAEHGQPAHAGHQQGADGYYDESGYYNADANNPYQHDGGYYEGHGHGGQYQDEYYNDQYYDQGAAGQQHPPGKRRGQDSEEDSETFSDFTMRSDMQRATDMDYYGRGDERYNSYDASQMGGNGYRPPSSQISYGGNRSSGASTPNYGIDYNNVLPAGQRSREPYPAWTSDAQIPLSKEEVEDIFLDLTAKFGFQRDSMRNMYDHLMTLLDSRASRMTPNQALLSLHADYIGGDNANYRKWYFAAHLDLDDAVGFANMKLGKANRRTRKARKAAKKAASADPENEQQTLEQLEGDNSLEAAEYRWKTRMNRMSQHDRVRQIALYLLCWGEANQVRFMPECLCFIFKCADDYLNSPACQNLVEPVDEFTYLNNVITPLYQYCRDQGYEIQDGKYVRRERDHNKIIGYDDCNQLFWYPEGIERIIMEDKSRLVDLPPAERFLKLKDVNWKKVFFKTYLETRSWFHLLVNFNRIWVIHISFFWFFTAKNSPTLLVKDYRQEENNQPPGSAQWSAVALGGTVASVLMLIATLCEWSYVPRKWAGAQHLTKRLLFILVVLVINVAPSVYIFIIQGTQKTKIALILGIVQFFIAVATVFFFSVMPLGGLFGSYLTKNSRQYVASQTFTASYPRLEGNDMWMSYGLWVVVFTLKLAESYFFLTLSIRDPIRYLASMDVANCMGDAIIGTVLCKVQPKILLGIMIFTDLCLFFLDTFLWYIIMNTVFSIARSFYLGVSIWTPWRNIFSRLPKRIYSKILATTDMEIKYKPKVLISQIWNAIVISMYREHLLAIDHVQKLLYHQVPSEQEGKRTLRAPTFFVSQEDHSFKTEFFPAQSEAERRISFFAQSLSTPIPEPLPVDNMPTFTVLIPHYSEKILLSLREIIREDEPYSRVTLLEYLKQLHPHEWDCFVKDTKILADETSQFNGDYEKNEKDTAKSKIDDLPFYCIGFKSAAPEYTLRTRIWASLRSQTLYRTISGFMNYSRAIKLLYRVENPEVVQMFGGNSDKLERELERMARRKFKMIVSMQRYAKFKKEEMENTEFLLRAYPDLQIAYLDEEAPLVEGEEPRLYSALIDGHSEIMENGIRRPKFRIQLSGNPILGDGKSDNQNHAIIFYRGEYIQLIDANQDNYLEECLKIRSVLAEFEEMTTDNVSPYTPGVTNPVVNPVAILGAREYIFSENFGILGDVAAGKEQTFGTLFARTLASIGGKLHYGHPDFLNGIFMATRGGVSKAQKGLHLNEDIYAGMTALLRGGRIKHCEYYQCGKGRDLGFGSILNFTTKIGTGMGEQMLSREYYYLGTQLPLDRFLSFYYAHPGFHLNNMFIILSVQMFMLCLINLGALRNQTILCDYNKHVPITDPLYPTGCSNLSPVLDWVYRCIISIFIVFFISFVPLVCQELTERGFWRAATRLGKQFCSLSPLFEVFVCQIYANSVQQDLSFGGARYIGTGRGFATARIPFGVLFSRFAGPSIYLGARSLMMLLFATLTVWQAALVYFWPTLLAMCISPFIYNPHQFAWHDFFIDYRDYLRWLSRGNSRSHSSSWIAYCRLSRTRLTGYKRKALGDPSAKLSGDVPRATFTNLFFGEIFGPLILVGATLIPYLFINAQAGVIQSNNEGKTLHASGALIRVGLVALAPIAVNAGVLAAMFGMACCMGPLLSMCCKKFGSVLAGIAHGVAVVMLLVSFEIMFFLEGFVFAKTLLGMIASAAIQRFIYKLIVSLALTREMKTDTSNIAFWTGKWYSMGWHSFSQPGREFLCKITELGMFAGDFVLGHMLLFAMLPVLAIPKIDKAHSMMLFWLRPSRQIRPPIYTLKQSKLRKRRVLRYAILYFVMLVVFLALLVGPIIAGPMILSNMSSLETSIPLYLFQPTGLNNNDTRNRTETGTGAVSGAASTGSAATAKIRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RID4</accession>
    <name>A0A3D8RID4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_07130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RID4"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03046">
        <property type="entry name" value="GST_N_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF9">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW73688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="233" mass="26264" checksum="1E56B103C91C0187" modified="2019-01-16" version="1">MAAQDNKPTLHHLNDSQSQRILWLLEELDIPYNLVFKERNPASDPVAPYQAPAALKATGPYGRSPLLITGAQDGHRYIAESQGIVTYLLRTFDRDGKKFGHADWIRDEILCSLITTSLSRANFCVLMLDFGVIKNGSKDIMDIPGLHATLANFECELKEGGGKWVMGDRPGRPDTLAEFALTTARARKWVDYEKDFPALNAWLAMAYESPAWKRAMEKDNGYDMAVFPRFPRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIK6</accession>
    <name>A0A3D8RIK6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_07228</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIK6"/>
    <dbReference type="OrthoDB" id="10006946at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF9">
        <property type="entry name" value="FERRIC REDUCTASE TRANSMEMBRANE COMPONENT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="235"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="12">
        <location>
            <begin position="276"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW73786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="569" mass="64449" checksum="97F4C02439DFE698" modified="2019-01-16" version="1">MAWPYHFVELTDVQKHERRVLLDRYGAYAQLSALVPILAFQLYRLASWVYSERQRAKIAYSAIPGSPRAKEARNSTMGAFLQQWRSAMWWLGGDVAEGWGTRGRWIAGASWTVWLLFLSIHKTGDDYLHVTKRFGQVALSQFPLHYMLALKSRYSPLALVFQSSHEELNPWHRTLGRIIYGMILLHATWYLNFFFQSGILRSRLTVPIIIIGLVALSMMTVLATSSMEVVRRWNYRVFFVLHLVIGSTLLPLLWFHAAALRWYVTEALLVFILDIVFRKMDTITDYVKISKIPQTKLLKLKVPVPSSKIGRFQAAPGQHVYLSIPSESAPSASSVALHSMLFNPFTVADVSETSITLVLRALHGPISQTLVHLTELSKARPPINIEGPYGTSKKFPSLLTDYDRVLLVAGGVGATFVIPIYNSLREQMEAESVSPDRLKLVWSMRSSAEASWVMDLDERSSISKDEHAQIFATKNTSYDRQTEEVQPADGSVELDDLRSPRQQTLPINGGYGRPDLATIVDTVFMQGSEEKVAVLVCGPVEMARELRGHVGRWVEKGRNVWWHNEAFGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIQ7</accession>
    <name>A0A3D8RIQ7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DASH complex subunit SPC34</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">Outer kinetochore protein SPC34</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BP5796_07173</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex SPC34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIQ7"/>
    <dbReference type="OrthoDB" id="10016597at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013966">
        <property type="entry name" value="Spc34"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08657">
        <property type="entry name" value="DASH_Spc34"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="10" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="12 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="174"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="20">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="209"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RDW73731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="244" mass="27350" checksum="FADE9828BBBF88CC" modified="2019-01-16" version="1">MSLLAKHLEQIAFSFPPPKIFTNALLSTSDITSLIRDTEPHERALFSVPPPLPPSTAQNPDPQASSNRRQTVFNVASGEVVPSNGPSARAPRKNTAVAAVLGGELHSQIKKNEQGKGEFDIEVLLRGAEKLNDVHPTSGVSERIQSIRTRYAQLNTSLRHYEAKVARQTRELERMHRGVDADSEEEDGESMPGEDDREDHEMEIEVTDEDLRREEEEIRELERKKKALEDRVSGMERDLGGLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJ64</accession>
    <name>A0A3D8RJ64_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zinc metalloprotease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_07531</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJ64"/>
    <dbReference type="OrthoDB" id="4953at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000015">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000031">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000036">
        <property type="entry name" value="Putative zinc metalloprotease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000042">
        <property type="entry name" value="Zinc metalloprotease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF16">
        <property type="entry name" value="METALLOPROTEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07610)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="2">
        <location>
            <begin position="61"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="3">
        <location>
            <begin position="198"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1021"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1062"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW74089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1062" mass="117553" checksum="68647127D5FC3BE5" modified="2019-01-16" version="1">MPGQIMNTHFRTIQKFQTDYAPITISQYVSERTGMHVVLVDQKGPKVNGYFALATEIFDDSGSPHTLEHLVFMGSKSYQYKGILDKLATRAYSNTNAWTATDHTAYTLDTAGWEGFAQILPVYLEHVILPTLTDEGCYTEVHHVDGEGNDAGVVYSEMQGVQNNGGEIMDIRARQLLYPEGVGFRYETGGLMEQLRVLTAERIRAFHREMYQPKNLCLVLIGEIDHDQLFEILDSFEESILDDIPPPDAPFKRPWVDSPQAPPLEETIIETVKFPEEDESTGEILVGMFGPDCNDPVLTAALNVLLTYLAGSSVSILENIMVEKEELASSIGFWWDSRPSTVIWFQPTGVATKKLAHVERRLFELLEEVASKPIDMNYMSDCLKRELRQLKFQAESSSSFYATGIINDHLFGTRDGSTLKDLGTIKEYETLQAWTDEDWRAFLRKWITDAPHVSILGTPSKELSDSIKAQEEARIAKRKEELGPEGLQKLADKLSAAVAKNDLEIPASLLQKWPVPGVDSIHFIESMTARSGLAKKHGIPSNKIQQLIDAQDEQSPLFIQFEHVPTNFVHISLLIGTSELPKTLKPILPIFLDNFFNTPISRANGVVDFEQVVTELEQDTISYSMAGGGRVGDAEGVVIQFQIEPDKYATAIEWIRTMMFDSIFDKTRLKAGITKILADIPDSKRSGNSMMYAVDAMIHLSKDSITKARGTLVKAVYMKRLKKLIDFDTEVTLSWFNSIRTCLFKFHNIRALVIANVETLPNPVGAWKPLVDQLGAEAPLLPVIKQSSRLSPDGQNPGSYGAVVVPMPPIDSSFCMSTVRGPTSYDDPALPALLVAISFLEAVEGPLWTAIRGTGLAYGASFGRDLEGGFLQFKVYRSPDAYRAFAAGKAIIENYLSGKETFEEYALEGAISGIVVAMADEQPTMAAAGQLNFINSVIRGVTSDYNTRILKAVRDVGVDQIKEAMKQYLLPVFLPGKANVVVTCSPATQEAIVKGFTESGFKTQVKPLSDFEDYYGLGDNHPPALSYPEGLFDGSEEDTDLDSMDIDGSDEESDGSDSGEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJB0</accession>
    <name>A0A3D8RJB0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">U three protein 23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_07373</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in rRNA-processing and ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the UTP23/FCF1 family. UTP23 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJB0"/>
    <dbReference type="OrthoDB" id="25675at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09865">
        <property type="entry name" value="PIN_ScUtp23p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000006">
        <property type="entry name" value="rRNA-processing protein UTP23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057776">
        <property type="entry name" value="UTP23_sensor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24779">
        <property type="entry name" value="UTP23_sensor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="UTP23 sensor motif region" evidence="9">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="172"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="193"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00076388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF24779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW73931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="307" mass="33842" checksum="192F0A9F27B00B98" modified="2019-01-16" version="1">MRGKRSKQYRKLMQQYGLSFGFREPYQVLIDAEILKDANRFKMDLVGGLERTLHGKVKPMITQCSMRHLYAATNEPGMSFVIDKAKLYERRRCDHRPEDYPEPLSAKECLASVVDPKGAKTNKHRYVVASQELEVRKHMRGILGVPLVYINRSVMIMEPMAGATVEMREKEEKVKFRDGLKGRGSGSQGMKRKREDDGDDKETANEGADAAAKKKSKYGKGPKGPNPLSVKKSKKKADGDATAPEKKQGAEEAGDASTVAPTVDGSEPGSKKKRRRKHRSGNEGGDSEAVAAAGEGAEADMDVDAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJB9</accession>
    <name>A0A3D8RJB9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_07585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJB9"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF105">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G08790)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="29"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW74143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="297" mass="32836" checksum="67039658F4493F60" modified="2019-01-16" version="1">MPDHCADCFKGFVHDGIPAGEVSTIHGLRVYVARPDDGVKPKGLIVMIHDAFGMEFVNNKILADRYAKRGGYLVYLPDFMDGHAMSPEVMTLMDKLFLSSSWLTTLLYKPIYCAQLMYHVIPWKRNVTHAVSHTRVFSFFQKLRTSPPPFATNSLKIAAAGFCWGGKYTVLLAQDTPSSRVPRFSEDSTSHASATPEALIECGFTAHPSMLEVPGDIEAVTLPLSIAVGDSDMALKGPLVLQTKEILEKKDVGHEVNILPGAKHGFSIRPNPEDELQMEYAEKAEVQALAWFGKWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJG6</accession>
    <name>A0A3D8RJG6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_07433</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJG6"/>
    <dbReference type="OrthoDB" id="5353310at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW73991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="113" mass="12932" checksum="C8F854023407F906" modified="2019-01-16" version="1">MGRPRPQKKAPRPSPLAQVQFTRPISATPEMGLVRDPEFWKRFSAAAHQAEEKEVPQSSSSRDSDDGDHWLAQQHREKRRCRCICLVTTLIVALLITAGAVVAWYFTKYRKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RND7</accession>
    <name>A0A3D8RND7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_06433</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RCAN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RND7"/>
    <dbReference type="OrthoDB" id="17212at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008597">
        <property type="term" value="F:calcium-dependent protein serine/threonine phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019722">
        <property type="term" value="P:calcium-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12434">
        <property type="entry name" value="RRM_RCAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000503">
        <property type="entry name" value="Calcineurin binding protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006931">
        <property type="entry name" value="Calcipressin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300">
        <property type="entry name" value="CALCIPRESSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10300:SF14">
        <property type="entry name" value="PROTEIN SARAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04847">
        <property type="entry name" value="Calcipressin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW75612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="258" mass="28275" checksum="E884C16CDABAF97B" modified="2019-01-16" version="1">MSAESSPPASRPASSSSSIRRSRTGTPLSIDLSAIPPLVLPTPPSNTLLITNLQDAEIFRPDNLQTIKELVNSSAPIHSWAPLKSFRRIIVSFFDEDSAIRIKQILDGEEIMGERVKVYFGQPTSIEVKDEHLNLPDAGKLFFISPPPSPPHGWEMKLEDAPNKLVHAEDLAEALAKLHHRPQTDLPASPNSDGGNYSGRTRSGSCTTIYHPSEHGHSPNLPAIEVEDFTGANDMSPVDMDRPIMAHTSRPPVELMEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RNF6</accession>
    <name>A0A3D8RNF6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">50S ribosomal protein mrp49</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_06410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RNF6"/>
    <dbReference type="OrthoDB" id="1696305at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007741">
        <property type="entry name" value="Ribosomal_mL43/mS25/NADH_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040049">
        <property type="entry name" value="Ribosomal_mS25/mL61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274">
        <property type="entry name" value="MITOCHONDRIAL RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13274:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05047">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00916">
        <property type="entry name" value="L51_S25_CI-B8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein/NADH dehydrogenase" evidence="6">
        <location>
            <begin position="40"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW75589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="198" mass="21584" checksum="64CAA96659AAD9F0" modified="2019-01-16" version="1">MVSVVRRMRNLRTLLAIRLGPGAAVFPPEVNRIHMDFAAKPLDGHMGPRKFFKQCLPRLKFHNPAVPMTVNRTTDITGPATLTIHFADPATAGKTSPAISSTTSSTTSTGPVAASTSPAPTVRTETIQMKHVHESEILSQVMALTKAKIVLPTPEEEQEIKDLQQQRVESEEISKKAKIAKEARKRAEAVISAAREST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RNS4</accession>
    <name>A0A3D8RNS4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_06538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RNS4"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017787525" evidence="1">
        <location>
            <begin position="19"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW75717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="92" mass="9553" checksum="0C7BB3DB38897ED1" modified="2019-01-16" version="1">MKLTATLFVAALAGTVVATPIPDKRAPGYGTYTTYPPPPGGYSSYGSYTGAGTTVPVPSVTPAAVTSYGSYGKYASYGSYPRALEFLKHLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RNY0</accession>
    <name>A0A3D8RNY0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_06574</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RNY0"/>
    <dbReference type="OrthoDB" id="286301at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.180.10:FF:000032">
        <property type="entry name" value="Fasciclin domain-containing protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF77">
        <property type="entry name" value="FI19380P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017574474" description="FAS1 domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="19"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="169"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW75753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="375" mass="38003" checksum="55B2C12FF4743C51" modified="2019-01-16" version="1">MHLQYLLPVALAAVAAAQNRTLAQAIAGQSSLTTFQSLLSAQPALVRTLSNASSITILAPSNDAFSKFLSTTDGKAASAQPDIVAAVLQYHVLNAEVPGSAFTTAPQFVPSLLTNSTYANVTGGQVVEGILNGKTVEIYSGLKQKSTVTTADIAFQGGVMHIIDNVLTIPPSDAVTAIDSQLTSLAGALAKANLVTAVDDLKDVTIFAPSNDAFKQIGGTVQSLSAQQLSTILQYHVIKGTVGYSTLLIGGLANETLPSLNGAGLNILIEDNKVFVNSAQVTMADIIVANGVMHVVGNVLNPDNTSAIPNPTATTQSIAFAGATSAANAPFTSGINPTTTAPAAGKTSNAAAARQTGAIGAAALFGGAAMLAFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RP55</accession>
    <name>A0A3D8RP55_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_06693</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RP55"/>
    <dbReference type="OrthoDB" id="10258955at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF5">
        <property type="entry name" value="AMIDOHYDROLASE 3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="422"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW75872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="951" mass="102890" checksum="D7DC01256CC61C2E" modified="2019-01-16" version="1">MGLPTLQEPVSHRHRKRGHFRLPLSIVSAVGVILFLQFSILPRYISRSSPEALAVSQLQLQRLDAGLAKCAEFNAPVVQYEKPVSAARENSRWNSKSGQNDTIMLRNATLFDGESFVKGPVDIVFKKGVVVSVMPASSTEVEGMTLIDLGGRFVTPGLVDMHSHHLDGGWPILKATSDENEMSTKAWGPLTPFVRALDSMHAYDIATTIIASGGVTSSLILPGSANIMGGEGFMVKNILRSGPNGEEVVEEILLEHGIPVKERRRYMKMACGENPQGLYGHTRMGNAFILREQMATAEDLRQKQDMWCKTAIAARSSGDSDAVARLTVSGGLPESLKLDSSVAMLRGKIGINVHCYETEDMWDMIQHSKEFGFRIQAFHHALEAWKVPEMLKDSGENITVATFSDFSLYKKEAYGANLYAGKILAEHGVPIAYKSDHGEEQTNAKYLLFQAANGHAFGLPADLALQSVTSVPAKSLKMDHRIGYLRPGYDADIAVWDSHPLSLGATPLQVYIDGKATLDPVQVKKSQSKVKLQNTKIQESPVSRPTLDTVVKEELCQNVETPGSKVVITGITRSYLGLSKTKSSSSGNHTMVMTGGEISCFGIHDECLSASKGGIIIELKNGHVLPGLTAMTVNLGLSEIPSEASTSDGGIPKGDVMDPESVSYAKYGVHLEGRAFKRAKIGGVTRAITPPLIDTWSEQKSFLNGVSVGIKTSEKKTLLDGGIFKDDVALHVTIGQDSKSEQFPSISSAIAKLRKLLTSSAGKDTIYGRVANGTFPLIITVENKYDIMQLIKIKQDYPGINMVLKGGAGMPFVAEELAAAKIPVILTSHRGAPDSFEKLDTLIGPPLTRSPASILTDAGVTFALAINGFGDPYIHNLPLEAGWVAKYSGLDDDAAVNLVSRNVEKILGLNVDEETRDWVVYEGNPLEFGASVVLAVDGLDKEIVSCWPYSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RP87</accession>
    <name>A0A3D8RP87_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RTA1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_06723</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RP87"/>
    <dbReference type="OrthoDB" id="4521223at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW75902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="34209" checksum="65DC993D80118168" modified="2019-01-16" version="1">MSDLQYFLNGSVIDPISCHQTDCCTLAICPLEYALIHHLPNVAGTVIFLTLFTILLIAQIGLGIKYRTVYFTTAMVCGLILEVLGYVGRLMEHNNPFNFSAFLLNLIPLTIGPAFMCAAIYICLGRIVVTYGGGISRLAPSTYTFIFVASDFLSLLLQSAGGAVTSIAPADNRSLSQAGIHIMIAGLSLQVVSLVIFIVLCADFGYKALKNRQDWEVAHEDIWSSKRWTIFLGALVIATITILVRSAFRVAELSQGFHSKSANNEVNQLVLEGTMWKELSFGWRKNRDAETTSRAKVIKSESDFQKPAVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPG2</accession>
    <name>A0A3D8RPG2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_06760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPG2"/>
    <dbReference type="OrthoDB" id="2832510at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13508">
        <property type="entry name" value="Acetyltransf_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW75939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="221" mass="25499" checksum="5E2BA454BB81AF19" modified="2019-01-16" version="1">MASSYQVRLATRDEIPQVAVVVEEAFKDNEIFRYMTPTATPDQNYAWRRGMFEDEWTLPGRKLFVAVHNDTKQIVGAARWYFPYTLTEEENKAGVGIDVLEGPEPPGCIKELYQDFFTRLFAYRRKYTDHNDTYVLDILAIHPDHQRKGLGSLLIRNVLAQVDREGRRAYLEASAAGKGLYLKLGWEEIDEMHVDVRPYGGHGVEKEKIMMRPAVKATERE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPH3</accession>
    <name>A0A3D8RPH3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_06726</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPH3"/>
    <dbReference type="OrthoDB" id="10255013at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15849">
        <property type="entry name" value="SNARE_Sso1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000008">
        <property type="entry name" value="Syntaxin family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF380">
        <property type="entry name" value="SYNTAXIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="9">
        <location>
            <begin position="261"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW75905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="462" mass="49801" checksum="F34E9A8F3E127CE1" modified="2019-01-16" version="1">MSQQYGYGGQANPYAQQGGGGGLPSGPRAGGLPTGPRGGRANAGPPGGGFRQEYNAPQQSPSYGGYSDAPSMGRDDYGGQNVEMAPLAQNGQRFAGGGGGGDPNAILNECREIDRGVDSIEQNLDRLKMLQQQSLNDADSSTNSATNRQLDAISSETMTMYRNFAGRIKAIKSQPESGTPKNAPQVGKVDRKLKAAINKYQNVESDFRRKMQDQMARQYRIVRPEASEEEVREAVEDTSNQQVFSQALLQSGRQGQSRAALAAVEDRHKAIQKIEQQMIELAELFQDMDVLVTQQEAAVENIEMKGEEVVENMDKGTQEIGVAIESAKSRNRKKWWCLGICVAIIAVIVIVILIYKFVIQGGSTTTTTAASSTTRKRSLGAQVHGNRVINPHNAAAEKRNVVVPGLLWTEDNKLVASGAEFKGGKSRIATPGPEFQSKKALAAGLRFRGGAVRPGVDFKSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVL1</accession>
    <name>A0A3D8RVL1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BAH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_05949</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVL1"/>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04370">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46364">
        <property type="entry name" value="OS08G0421900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="2">
        <location>
            <begin position="111"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW78097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="359" mass="41152" checksum="D3CA6BC581C78F00" modified="2019-01-16" version="1">MAQNGLKHELDSLSSSPPPSKKRKTASPTPSVSFGMTDPDPDWQVTYLSMQSYRDPQDKDYKRARLAEPYISAFTDVKEQADGTLDRCYIVSPTDKWQGMRKYNSFVIDEVKYHLGEYVWVKHGLEPQTKTMHEKDFWIGKILEIRGATTSHVYALVNWMYWPEDLPLCQAPNELKPISGRRGYHGRREVIASNVLDAIPVLTCAGKVDVIHWLEEDDEDAITTPLYWRQTFNEENNELSGVRLHCVCDQPYNPDTTLLGCENPMCHIWLHKECILDDILTKTHDRLIGPLDDEQKRKLAKSKTSKKCYTGKFKADFKGDAMVPDVTITDIRKGQNGNTWTEAVYCPKCGFDMTSDRPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWB8</accession>
    <name>A0A3D8RWB8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Outer membrane protein TOM13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_06128</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWB8"/>
    <dbReference type="OrthoDB" id="5529571at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070096">
        <property type="term" value="P:mitochondrial outer membrane translocase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013262">
        <property type="entry name" value="OMP_MIM1/TOM13_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28241">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28241:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08219">
        <property type="entry name" value="TOM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW78276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="130" mass="14088" checksum="EAE2FBD28170BC9F" modified="2019-01-16" version="1">MASHDSLNNMTESAMTIPSDSEQYSGNDELSPSPPSSSSSPAMILYSPPTVWSLLRGAAINLVLPFVNGLMLGFGELFAHEAAFRLGWGGTKVFPLGRSSRTVGPGIEVRDDPFEKRRRNGQLEDLTSME</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2E3</accession>
    <name>A0A3D8S2E3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">isopentenyl-diphosphate Delta-isomerase</fullName>
            <ecNumber evidence="4">5.3.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_05171</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>isopentenyl diphosphate = dimethylallyl diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23284"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="EC" id="5.3.3.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:23285"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Isoprenoid biosynthesis; dimethylallyl diphosphate biosynthesis; dimethylallyl diphosphate from isopentenyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the IPP isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.3.2" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2E3"/>
    <dbReference type="OrthoDB" id="510307at2759"/>
    <dbReference type="UniPathway" id="UPA00059">
        <property type="reaction ID" value="UER00104"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004452">
        <property type="term" value="F:isopentenyl-diphosphate delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050992">
        <property type="term" value="P:dimethylallyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009240">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02885">
        <property type="entry name" value="NUDIX_IPP_Isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000012">
        <property type="entry name" value="Isopentenyl-diphosphate Delta-isomerase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011876">
        <property type="entry name" value="IsopentenylPP_isomerase_typ1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02150">
        <property type="entry name" value="IPP_isom_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10885:SF0">
        <property type="entry name" value="ISOPENTENYL-DIPHOSPHATE DELTA-ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018427">
        <property type="entry name" value="Isopntndiph_ism"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="13">
        <location>
            <begin position="76"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007579"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW80473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="255" mass="29429" checksum="012C9C63F40A907F" modified="2019-01-16" version="1">MSTTTLVAAPAEPITAQNILRLFPDIDTSSAELDGHDAEQIRLMDEVCIVLDEDDKPIGNFSKKICHLMTNIDKGLLHRAFSVFLFDSKNRLLLQQRATEKITFPDMWTNTCCSHPLGIPGEGGAELAEAVDGVKRAAQRKLDHELGIKKEQVPFEDFHFLTRIHYKAPSDGKWGEHEIDYILFIKADVDLEPNLNEVRDTQYVTADELKKMFEDPTLKFTPWFKLICHSLLFEWWEHLDQGLEKYENEQQIRRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2I4</accession>
    <name>A0A3D8S2I4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_05174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2I4"/>
    <dbReference type="OrthoDB" id="10343999at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW80476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="147" mass="16559" checksum="089FCA2E98124498" modified="2019-01-16" version="1">MAAQEENVTPTTEAPAPIPGTKLTARQRISSELSARAAAKETFKFEKPKMGVLEQRKLNKYHLTQMGKYSEDFEVLLKEMEDETAEYIVHKGQEILLLMSTDEAGFVPKNIKEAAVQRFMLSVQRHLHYQFAAALADHLNLNGDVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2R0</accession>
    <name>A0A3D8S2R0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Siderophore iron transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_05062</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2R0"/>
    <dbReference type="OrthoDB" id="2241241at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015343">
        <property type="term" value="F:siderophore-iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000197">
        <property type="entry name" value="Siderophore iron transporter 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF92">
        <property type="entry name" value="GLUTATHIONE EXCHANGER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="501"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="544"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW80364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="591" mass="63839" checksum="CB3197D7EDF5450D" modified="2019-01-16" version="1">MALQGDGPQDLTATKDVNARDSDEHTTPRLLGFGSIGVQRIEAITAQFRSIDRIVLFLSILLLAFVYDLDGTVRYTYQPVATAGLGHHSLLATITVLRAIIAAAAQPVAGKVADVFGRVELLYLSIVFYVVGTIVEATSTDIPQLAAGAVIYQLGFTIVQLLVEVLIADVTSLRSRLFFSYVPAAPYLIITWVSGNVTSAVLGVTSWKWGIGMWAIIYPVCAMPLLTTLLLAGRRAKRAGQLQDFKSPLQQLGAKNLVIELFWQLDLIGCILVIAVFGLILVPLTLAGGVSETWKTAHIIAPLVIGFLCIPVFIFWEATCKHPMIPFRLLKDRGVWGALGIALFLNFSWYLQGDFLYTVLQVAFNESIKSATRISSLYTFVSVLTGLCVGIMVRFLKQLKWFIVGGACLFTVAFGLLIRFRGGGGASNHSGVIGAQVLLGIAGGMFPYTAQASIQSATKHEHVAVITGLYLATYNVGSALGNCVSGAYWTNTLPRKLAENLAFTGNATFASTVYADPFTFIAAYGMETPERIAVVEAYKSTQKVLCIIGICLTLPLIAFGLCTRNPKLGKEQSLAHAEESGSDSVSMEERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S9J9</accession>
    <name>A0A3D8S9J9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">ATP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
            <ecNumber evidence="9">4.2.1.93</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP-dependent NAD(P)HX dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_04518</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(6S)-NADHX + ATP = ADP + phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19017"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>(6S)-NADPHX + ATP = ADP + phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32231"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.93" evidence="9"/>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S9J9"/>
    <dbReference type="OrthoDB" id="8110916at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047453">
        <property type="term" value="F:ATP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110051">
        <property type="term" value="P:metabolite repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1190.20:FF:000043">
        <property type="entry name" value="ATP-dependent (S)-NAD(P)H-hydrate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017953">
        <property type="entry name" value="Carbohydrate_kinase_pred_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00196">
        <property type="entry name" value="yjeF_cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592:SF0">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01050">
        <property type="entry name" value="YJEF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 9" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF C-terminal" evidence="10">
        <location>
            <begin position="8"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="171"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="210"/>
            <end position="214"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW83027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="322" mass="34648" checksum="C08C4F2499A7E5FA" modified="2019-01-16" version="1">MSSATKEILSKIQKIIPPMLGKFHKGQMGRIAVIGGSEDYTGAPYFSAMASARLGADMSHVICEPQAAQVIKTYSPNLMVHPLMRQSAHATASDSVSSISKSIIDMLPRLHVLVIGPGLGRDTLMQDTCAKVIEAARKQKMPIVLDADGLNLAQTKPELVQGYKECILTPNVVEFGRLCKSKGLDTSSLDKGKAAEELSKAFGGVTIVQKGGQDYISNGEKTYISDLQGGLKRSGGQGDTLTGTLGTFLCWRKAYLDKLWEHEGDLDEIETLALAAFGGSSITRECSRLAFSKRGRSLQASDLTEEVSTAFTNLFEEPASKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SA21</accession>
    <name>A0A3D8SA21_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_04614</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SA21"/>
    <dbReference type="OrthoDB" id="2253354at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035213">
        <property type="entry name" value="DUF5321"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17254">
        <property type="entry name" value="DUF5321"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW83123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="204" mass="22732" checksum="361E7FB8EB162008" modified="2019-01-16" version="1">MNRSAMSRRIFLAAPSLRSALISRQPAPSAALSYSSSAPNITSTSFWTSLVPKPLRRGDTSTSAKKGKTKSKEWNPATFFINIFLLIGSMSIQMIALRNDFAAFNRRADAKIGLLKEIIERVQKGEDVDVEGLLGAGDKEKEKEWEEVLLEIEREDEAWEQSRRQKPKHGRNLNDDATERPPAEAQKPSADIAKSKTNAPPGFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAL8</accession>
    <name>A0A3D8SAL8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04866</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAL8"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW83375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="608" mass="68096" checksum="FF8AB1EB67B2FD67" modified="2019-01-16" version="1">MDPQEEERTDFNSIVFHLRSLARLLGSSGAQTLDHTLSQAPAASTPYLRLQAHLCDNPSGDGSSCVVQCSSDDIVLGQLDLRLLQQQLNSSIGIASPVSQAESPHAELNEPASTNQEGIERSLCSSSQPPEAFARRKAVGGLRLGPVAGSGTPDVASDNEATRRLQPDSREFPKRKSKKDLEKHTMEPTTLDKFINGVWKQLHSNLEISISDLTPYMDATGPDSTFEEFRKINELCLKTTKRSRAARALEIVVQAHWVDCFDARVRAVYNDDYPKLSAMDARVATIREACSTLQWSEKELRNRLGIWRGYKEIKDAGGWVPLIFAGNGIYRFCKYRTGFLKDSTVRFNSIRSSLEVAADTLHPGWRQVLSVLGASMPPKYHGHPHDWVMSTEEAPRRLRECYPDQDFQFEHIEESVLDQEAWGDEDPRRLPDTGEMNTICSDCRLQQSDDTKVNRCCCFPELFGDKRAPCPVQIFRTANGRNNGLIARSNFERGTAVGEFVGLITKSLRNIDSMQGGTGKNRYQIYQGKQGTSLSSLRGLPRLSIAQYLLNSPNRKLHTLHQPLMQAKLPVPEVLLAWHREDHRGFEGRHVWAGDHSRLLGSVLAGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAM5</accession>
    <name>A0A3D8SAM5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">IPT/TIG domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_04692</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="71307at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00102">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057962">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25603">
        <property type="entry name" value="SPT23_MGA2_DBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00429">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1379"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="6">
        <location>
            <begin position="833"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1020"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1053"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="82"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="183"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="416"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="493"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="595"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="746"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="779"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1111"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="134"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="213"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="614"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="639"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="655"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="691"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="782"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1113"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1149"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1181"/>
            <end position="1192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW83201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1425" mass="155581" checksum="EAB4ABE6403E3EF3" modified="2019-01-16" version="1">MESAASMSSPPFMLDSDMSRKLDSEPDLEDFFDSSLPPEAVTSPCIFLADDYNADSSHFTSFETPENSIFKSPIPATSFLDTKTNQSLSAPSTASPAGSYQDSASDSSGYKRKSSSDSSRSAVTSGDVMMGDDTDMRDWKLEDMNNGNDQSKFGNHDGTINPASMDKDHTFNDKAMENDFDFESAASSPSPFGFSIDMDSPDMPTLKYDPPRRKSPMPKSRLIRNHSKGNSQHSITQSMNGLTTTASREVSPLSAMVTSQESSPSAFFNNSPSPSTGIEFVNGNMLNGGHAPQPWPGTFDFNTSALMAPHHPPPMMNAPQANGFPILGSPYKPILTIHPTPLKSRVETQIPIKMTLFPLPMGITKLHLPTHTISKPKLLAKPTPDRASDTLELSTMLVCTSAMQNPDHRRRAFAKAALPEAQREAASASPREDDEDDENRPLNGGEVKICPGCITRERKRAARKKVKKVEEEESWHKDEHKRVIVFNTHETKDWQSPTAQAASEATGDRQEPMVPDGAFQVDAPMRIACYCRHQNEKLGFQVIFTIKDYQDRLIAQEITSSIMITDDHKTHNLPALPTQTSNATDGQTIPTLSTETTFDLPSGPVGGMAPFRISHSSSDLQSLQNIQRTFPSPYPPMPTSSSYTSQTTSATMTPRNLSRQASPSASNGPSTKKRKSSGSGKVPTGLAMTKLETSQPTPNPITSAPATGTIPTSATSPFTPNITNFPMPTDQSFGQPLGVLPHIPQQFNTGPPTPNSNDQFFSPPNRSHSMENLAAMQQQMYSAPASSHPSRAPSPNGGLRNNVAAYQQQQVHIAQAVASSFYGMQLALNPQRPPTIHKLIPGEGPKAGGIEVTCLGSGFCQGLEVMFGDAMATTTTFWGETSLVCLLPPAAFAGSVPVTFKHQHHQVQSYPAPPMPKQQAYFKYIDDDEQQIIRTALSVLGHKMTGKMEDVRDLARRIVGDGPSSWSSAASPTGGQNQQLSNFNAASFGVDTEATLLKVLDLIDLDDSPNLPRWNLRRASGQTMLHLACSLGLHRVVAALIARGANPEPRDKGGFTPMHFAALHNHPQIVRRLILGGADPTVRSLQGFTAADMASSEEVYRAARRIEYHSRTRSGSSLRSRTSSATSLRSLWEPELGGSQIDNHSIVSDSEDDDNEYEDEDADAAVDGAFWMRSRRPSAQKGLSRTRTTSPEPKQPLLEVPGHALPSPTAAVAAFRDQLTAQIHHFQQSMHLNLPNLPQMPTFNDYQNYLPTPMVRRISNLAGNTNAAPTEPVKEQESRWWDRFSGTVAPPAYEDIYPQSGIDAKHASAAQAAADAVADNKCAELFDQAESSTSAQKRRGPLEKVTISSKHTLTKEQQDQLRQAHAQAIKKTRNDRNLFFIWIPLLLVVVLATLYYRLPMAWAGALEFLESVRSRNDPGRFVEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAX4</accession>
    <name>A0A3D8SAX4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_05008</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="10601337at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
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            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW83517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="227" mass="22628" checksum="74F04C22FAC1D581" modified="2019-01-16" version="1">MSRALRARESARQSAVVNLDRRPNAEGGKDGDDAPTTAQSTKAKESAKSTKSTASKSTTAKAATTSGFAAPAATASSISLGQPAASVTIQSMGQPSPAAAASSISSGQPAVSVSVQSVTTTVLSMVPGPTQTVFITSTLAPQTVTVTTGQPTTLTPASKTTNAASSPSINLTAQSDTTTIVATARTGQIILGSGTIVLVVLGALAAVALLGAGAFIARQRSRQKRMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAX6</accession>
    <name>A0A3D8SAX6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitination network signaling protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_04914</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAX6"/>
    <dbReference type="OrthoDB" id="4158994at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="148"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="340"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="591"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="837"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="695"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="595"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="858"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="890"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW83423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="937" mass="102162" checksum="9A4CC489D9D7E5DB" modified="2019-01-16" version="1">MKPKRQQGAATHRDTRHENGLVGPGKRVNKQKSNGHLNGHAKTPDSIPSTPPLPATPPATSNGHVHQPADNIADHKMAMDSLRRPSVSSYQESSSSESYQNAPIISISPENHRRIDVNAAKNPAVHRDAGPLSLALTVLRSCPLGDTIAILIVLLQLPPTFLSIVHLLFATLTFVPPSNSPNSALSFTDIFEGTLGTPSLATIAVVDAFVLLIWILLWSPLQDILLDLAQSVIALTLGGGTAGRSGGMNNVLVCFGIIGVSHFAGGGNGKKAGLGMLLASSSRGFLGSSDPEDPLEPPPSVIKRGASAHGWIRSVLAIHILTQGVVRYIRDWYVRREKRDSSAATIGDPEAANGPSLVNSDSPTNNVQNSETETSTSTAVSHTVVTSKKKRKQSAQVRIRQPLWAALASTKVVMVKEYETSHTAAESVGANATGINDLGNAPFTAEADQVWITYVGFDEVYFSTSYFPSHTTDECEQKKALDPSGIDRSKPCYVRVNKTIWQPTRINVTIDPDQAPGQDARWSGEIFGLAPMSSYECDFVSTVDESIIFSTSVRTLQAPTTDLAAATLSPNTPIQGRPGSPTMTLKTSIASSEAKLNEERNRQKRERKDQRAKLHSSRKEIEKIIGNIASSGGNDDRLRQKVLQSKLHMKQAEDAVIQLASQIESLETIPTDDSSEWKYEKEAFQSQKDLHKQSRQDFQNVKAATEHDLQALNNEVAALQQKRERMQSRIAKLNGEHERITDANAKGLDEAQRKAREREAKDIERANLEMLYIQRSQDLAAEINETDASCQTIFATIQALQEALYISHSPTTALSQPHNPYSEIPEGNIPPTTYSPWNQPPPFYPGTGLPNAPRTRGRSSSMLSDVSGFTQWDESEQQFLPPPEFIPHFQHGEVGKERQKSEDNSSASGSRSGSSRDPKSPIGSKSTAAKWGWDEKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SGH0</accession>
    <name>A0A3D8SGH0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RelA/SpoT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_03755</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SGH0"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015969">
        <property type="term" value="P:guanosine tetraphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920">
        <property type="entry name" value="WD40 PROTEIN CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="RelA/SpoT" evidence="5">
        <location>
            <begin position="46"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="902"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="944"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="986"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1028"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1070"/>
            <end position="1111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="585"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="585"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW85430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1202" mass="135291" checksum="66A0F3B28530EF8D" modified="2019-01-16" version="1">MAQDDIPRLLASYSDNLDSYRSVEEEVKQVCETKLTEAGIRHLWQSRVKDIKSLENKLRERSRKRKRGNESPITNLDGIVDLVAGRVILFSVQDINPITELLKSNFILTEEPIQHPTSAQNIGRAERFRGYDGLHFRVRRKTPPDGPYQPYPHLVVEIQVVHIIMWLFNEQEHDQVYKGDGSTSIETIRSLEMLKGIANLYAEAFYQYESISQGNNRNGIPKRLQDFEYYIEQSRDLDRCILGSEAPQRSSSNDIASTDSNSLKNLIGILVEALQNSGKEDKGDDYHEASSLLDRLPYADEAPFNSYHRQHEPRCLPETRVGVLREIFDWADRHDNHFIFWLNGFAGTGKSTIARTIALDFHSKKHLGASFFFSRGVGNISHAGRFVTSIAVQLARSIPPLKQHICNAIRERGDIASQSLHDQWHQLVLRPLSKLDAHGPPSTYIIVIDALDECDSSPHIGTILQLIAEARSLRKVRLRVFLTSRPEVPVRCGFYNTPQTEHQEFILHNISSPIIDHDISIFLVYELAVIQQEYILDATWPGEEVVERLVRKASGLFIWAATACRFIQGGRDFAADRLSIVLGDNSSNENSSTDDSSAEDDSIDDSTVSPEVQLNKIYLAVLQNSLRNYTRHERKHKYKRLREATGAIALLFSPLSVLSLANLLHIPKDEISRTLNDLHSILDIPKDPARPIRLHHPSFRDFLLSKDNCSDSKLRVEEKQSHRKLADNCIRLMSSSLKQDICGQKAPGTRVTDVTSSPIEQYIPSEVRYACLYWVRHIQKSNIQLFDHDQVHQFLQVHLLHWLEALSWTRSLSSGIVMIAKLEKRLKANESPDLYAFIHDTLRFVRHYQLLIEDTPLQLYCSALIFAPGESIFRRQFKKYIPPWIQSKPKMKELWNAALQTLEGHADVVASVAFSPDGKQVVSGSWDKTVRLWDATTGALLQMLEGHTDVVESVAFSPDGKQVVSGSWDRTVRLWDAPTGVLLQTLKGHSYVVKSVAFSPDGKQILSGSSDQTVRLWDAATGALLQTLEGHTDMVESVAFSPDGKQVVSGSWDKTVRLWDTSTGVLLQTLEGYTNVVESVAFSPDGKQVVSGSMGGTVRLWDTSTGALIQTLEGYTSDLTSVAFLPDGKLIPILAVLNQWVVAGKANILWLPPDYQHTAIDIQSRNLALGHASGGISIFNFSSGSELIISEVEYVRRKSRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHG7</accession>
    <name>A0A3D8SHG7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase delta subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04081</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHG7"/>
    <dbReference type="OrthoDB" id="337486at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007218">
        <property type="entry name" value="DNA_pol_delta_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04081">
        <property type="entry name" value="DNA_pol_delta_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="52"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW85756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="24416" checksum="8AF0AFE394CAD346" modified="2019-01-16" version="1">MPEPTLPQPPQTSPANPTITPHLSATMPVTRRSRNSSGPVAKGAQSRLSFGSKVTKSTTPSSKIHKPTSASTPPAKKEVPISLVQDEVDVGHVDSSAAVAQQAQAELAKPVKTEAEERADKVSDAQIRKYWRAHEMERKAPRVHQQDLGVEEKILRLFDMSSQYGPCIGIARMKRWNRAYKLGLQPPIEVLAVLLKEEEKGNNAIERAHVDSLMSSKFVVGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHQ3</accession>
    <name>A0A3D8SHQ3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thiamine pyrophosphokinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHQ3"/>
    <dbReference type="OrthoDB" id="10261522at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044715">
        <property type="term" value="F:8-oxo-dGDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03676">
        <property type="entry name" value="NUDIX_Tnr3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000019">
        <property type="entry name" value="Thiamin pyrophosphokinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13622:SF11">
        <property type="entry name" value="THIAMIN PYROPHOSPHOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="129"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW85879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="314" mass="35059" checksum="7DDC6D58528C1C18" modified="2019-01-16" version="1">MNTNLNIVKECDKWLGVALEYETQIASLWKFFLPDDPRPHGFLLDSVVDAMPWTTSFCLNASKKEVHLLKGNRDHWQAACNEAIDEILDLAREKGSFPKLGRKRDEKFPIVGANFSIAIERSASSLFGIIGQGVHMTVYTSTPTGLRFWIPQRNLNKSTYPGMLDNAVAGGVAAGEMPMECLIREAEEEAAISRDMVSKNARAAGTVTWFNISNEMAGGQPGLMNPGVLYVYDLEVGPDLVLKPVDNDVHAFHLMDLKQVQEAMKERRFKPASASVMMDFLIRHGLITAESDTDYAEIVSRLHRKLPFSTNPMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SI15</accession>
    <name>A0A3D8SI15_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_04320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SI15"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="70"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW85995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="395" mass="42608" checksum="BDB3DFCC45ECDA26" modified="2019-01-16" version="1">MGSRLCGCFKYKRKTDKVTLGTKESPSGKPAVLSKAADVVITTQDLSESCSTSSSLDLPKHMKALCVVSKHTYSISKDIPYPSIKSPDEIIIKTRAVGLNPIDWKSVDYNFCMPSFPWIGGRELVGVVAQVGANVKGFKVADRVWASTYYRDRRAGTFQEYVVCPQHTVLMLPSCLSFEEGASLGVAALTAAMTLWKWLDVPMPSRDVTSRIPPEYILIWGGSAITGQFATQLAVQSNLCVIAVTSAKTKALAERLGAGHVIVRDGKSNDDIVAEVLAIVGDDLTLAIDLVGDQTGASCVKALSTSKPAVLAPVAFLKTGERIPSNVRVVDVEMKRFVVEKGNQKYGEMLNKLISAGKVAIPEIQVLDGGLEMIEEGLAMQKRGDLGGRKLVVRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SI71</accession>
    <name>A0A3D8SI71_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450-6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_04354</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW86029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SI71"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF29">
        <property type="entry name" value="BENZOATE-PARA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW86029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="504" mass="56562" checksum="31C7A9D09AB96362" modified="2019-01-16" version="1">MGLLKSISESSALPNQPWNSQLVIIVYAVSQVIYNLYFHPLSGFPGSKLAAISHIFYARAVVGAGGSEEHVVKALHEKHDVLSDVVRWSPNELSFSSAAAWQDIYGTQRSGDIFVKDHNLKAPNIVFEKDPAKHLQAKKMLSHAFSPKALREQEDVILKYADMLMVAILEQSRKGPINLIDFYEWFTFDVLGELCFSEPFGSVEARKSDEWVATVLKMVKFVACDSAIYHLSPLVEAAIPYFMPAEFSKGMLSHVTQSKAKIIKRRDRGEKDRKDFCSYLFEIQKEMKQSDWELTANSQALIIAGSETVATTLSAMTHWLCKIPRAYLKLKEEVRSRFNSASEITSQSATFPYLTAVIHETLRIVPPVSHATPRTTPKGGKTVGGVFVPRGTSVSVAPFATTHNPKNFKDPDIFRPERWMDPKCTDKLNASNPFSLGPRACMGQNMAWIELRILAAKMIFLFDFEAIDKEIDWGRDVKSLGLWLKPALMTVVTPRNIPSQQMSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SI96</accession>
    <name>A0A3D8SI96_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_04226</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Beta-glucosidases are one of a number of cellulolytic enzymes involved in the degradation of cellulosic biomass. Catalyzes the last step releasing glucose from the inhibitory cellobiose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SI96"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF12">
        <property type="entry name" value="BETA-GLUCOSIDASE G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fibronectin type III-like" evidence="10">
        <location>
            <begin position="309"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW85901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="402" mass="42624" checksum="B5F32F976E1FE375" modified="2019-01-16" version="1">MCPVSLDTVDLSAKTSCTAFRDGRGNHSTLIRQIGGESMALLKKDNSNGGGLPLKKPHTISLFGAHASPAVSGPNYGWSVGGTGADVFQGHLALGGGSGETSLPYLVTPFNSLTQRAIEDNSMIWWITNNTFSSSSSGNSFGLASGTGVAPSFTEYASNSDRAVQHRAGRPSEHGSWLLQQHRRGRQRVRPGLEAWIENDNVTAVIYGGLLGQESGNAIADMLYGDTTECAFSEGVYIDYRWFDKQAIEPRFPFGHGLSYTNFTCATVTATITNSTALSSNLGGLADLFDEVTTVNTTVQNSGSLDGAEVAQLYVSFPDEAAQPVRVLHGFEKVNITTGATSSVSFSLRRRDVSYWDVAAQNWAVASGTYTFGVGSSSRDIRGNATLTISARSVVSPCGKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMF6</accession>
    <name>A0A3D8SMF6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Autophagy-related protein 28</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_03191</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SMF6"/>
    <dbReference type="OrthoDB" id="5342758at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="182"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="581"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="307"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="403"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="127"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW87497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="605" mass="66799" checksum="B5B1BE7938103C8F" modified="2019-01-16" version="1">MSRTTPFFSRRSPDSTSESFLPQYNDAHSLADLSPRPSTERNVSTSPPPSFYRSQNPAPKPNYISSEASSSRTHSVTGLSPGPTSPQRRRKIQFAAPPAPIAQSVLLHNEHLKHGKEGQASAGRNGDTLSGSVMMSTSGYRTRRKKSGSLDALLGLERREKAIQKDLQDLLDLQSAGLVQGFGGGSGGRPSATDIDGLSDAGSSTPTSRSVLLDRNTSQSREKTRGGVMPVRQPKKRSVGLRGARRGLLRDMGELVDIKIDESALIDLEINRREDALKNVKVWEERISGFGIKLRSATEDGEDNRIIAELRSEQKAVDTEIREMEDRLLQMRARKRWLGERINETVNKKEARLSSYRGALRDAETEVKEFLRRPPVDVSPISSGEEESFMALPPNRRTLGMAKEWWTKEISALEERRKEIELEKEALDEGAKIWEASMQSVMEFEDDLRTQMKIGVDDPEALKRQVAKMGSVISDLAANLKIAEEKHWNLLICAVGAEVEAFREGENILRGALGMSDSKDLVDVQPAAEAEVHVDGGVELEDDNDGDSVREGLEQALQGTIGSEGTAENNELQLRKLTSLEREVTDSSEDDGPPAELMFDHYSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SN51</accession>
    <name>A0A3D8SN51_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative competence protein CinA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SN51"/>
    <dbReference type="OrthoDB" id="2350783at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.20">
        <property type="entry name" value="CinA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036653">
        <property type="entry name" value="CinA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008136">
        <property type="entry name" value="CinA_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02464">
        <property type="entry name" value="CinA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142433">
        <property type="entry name" value="CinA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CinA C-terminal" evidence="1">
        <location>
            <begin position="11"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW87716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="169" mass="17620" checksum="6D21DA1B683DF381" modified="2019-01-16" version="1">MAEFPPAQIRPVAAEVAKLLKEKKETVSVAETAAGGLISAALIAQAGASAFYRGGLTVYTLESRVEYAGWTEADYKDYRGPTTDIVAGLATNTRTKLGSTYCVSESGTAGPTSPNRPVGYVALAVASEKGVFKKELSTGLGGDREGNMVAFAVEALTLLRDVLKGDAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SNP9</accession>
    <name>A0A3D8SNP9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_03610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SNP9"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF36">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G08340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="344"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="372"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="55"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW87916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="501" mass="55451" checksum="4B7AAA9EE0850534" modified="2019-01-16" version="1">MSIAGEPALTSSDTEKGHVIITSNKALDLLATHHVDFDPNSAAAKRVLRKIDMRIMPMVFTVYLLQLMDKNSLSFAAIMGVKADTGLTASQYSWLGSLVYFGYLGGEIPATFFMQRMPLAKYFSCMCMVWGILVTMHATCTSFAGLATVRLLLGFVEVCTAPAVIYITSSWYTKSEQITRVAIWYTTSGWANVFGGFFAWAIYQAPGFRWQGLFVFYGALTFLVGVILFFFLAASPTEAKWLTEDEKTIALERVRLNRTGTEVSSFNLRQLKEAFLDVRFYIVFLLLVSTGLPNGGLTAFGPSIISSFGFTTDQSTLLNMGSGAATVAGTILALFFAKYTSRTIAGVTWLLLSCVGVIMMFTIPVANYRARYGGYILTQQFAVCVLFIITFMTAGVGGSTKKFAFGAAYQLGYAVGCIIGPQTYRAQDAPNYYPAKYTMLAFLIFTCILLGTLGFLHLQWNKKRDEQDALDAQNGVIHETIENEEFADLTDFEMRSFRYPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SP44</accession>
    <name>A0A3D8SP44_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_03648</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SP44"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000188">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF50">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="436"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="49"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW87954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="496" mass="55198" checksum="936D4FD147C67A57" modified="2019-01-16" version="1">MASTDTKLEFEVKANNASDLEGGVEDSSVAYEIDPVAERALVWKFDLRILPFLSIIYLVNALDKSNLSNAKTAGLEKTLGMVDNQYSTILSIFIVPYVLSSPFLSLLGRKYGPHRVLPCLTLVFGTCTLCMVGVYNFSGLFAIRWFLGMAESAIFPLVIYYQTTFYRRRELGRRLAIFYAAHSFAAAFSGLLAYGVFRIKGGPLTAWRYLFLIEGLATVLVGLFVLWYLPRSTEECSFLTTEEKQLARRRLLQDSSSSVGVTKLELRESLKIFAQPTTWVILLIEACLGVPLNSVSLFLPQIIGRLGYSTVKTNLYTVAPSISGGVMLLLLGFSSDYTRLRFPFVAAGFAFTFIGMVIYAAIDVESSIHVAYFACFMMNWGTFAPSVLLDVWYNNNTPHEGRRVLLTSVGIATANLFGIVPSNVFRNQDAPKYIPALAMTAGFGGVGFLLTCGLGAWMIWDNRRRDRVQGVRLRASDVPTEKLRDGPMAAEFRWVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXD6</accession>
    <name>A0A3D8SXD6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phytanoyl-dioxygenase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW90975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SXD6"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051961">
        <property type="entry name" value="Fungal_Metabolite_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563:SF2">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW90975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="36497" checksum="EFB06ED27108FF53" modified="2019-01-16" version="1">MAPATLINDFETCPGGCRESEGTSKSVKSSQSPLPDVKEFESSSAAVDDIVSALKIAGGVIVRNFLDLEDINRILEDVNPYLEADKPWDGDFFPPETRRAFGLMGKSPTFATSMVGNPLWTGVTDALLTSHIKYNWVGDKNEESISVPQLHTTIVFRIGPGARAQPLHRDDTTHHPDHRAIAEHVLGRDCGVGLFVGATRTTKANGATRFIPGSHLWDYREGPPKEEQTVYAELSPGDAFMMLSGCFHGGSANTTKNEDRVLLSTFSCRGWLRQEENQYLANSIDSIRGLPPALQERMGYGLSRPFLGWVDLQSPMYILHPEVPKEQKDLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXV7</accession>
    <name>A0A3D8SXV7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SXV7"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="394" mass="41600" checksum="AE659869616BAA87" modified="2019-01-16" version="1">MAGLSTAKGHLGRVGGEILGRPRGSSVALAAVGLTGSVSEFPPQIGYGENDDATADAPYDRGTKGGCNDDLQGTGGIAERSSLYVICLGRCLSRDHMMILESWILRPLAALPPTMARGYACSNELETPAHICHRPAGRARAAGTECTGRPEGTREGWGAHILLRYGILGKGYVLFPEGFAAGMIQVGKVEEEWPQASQPHLTPEPSTDQPLNAVIDIRSIFRHLRSYRVTSHTNVTHPDADHRVVGDLGTGYLGRRDLDHLPTRGAEVVPCREDRVRIAAKVGPCFGSPGTEDRRGGTASGEQGELGKDRSVATMLSNPVRHASPRARGLGLTKGEGLAVVVFVHISTPYPIDALARAPAGSHGAPGAIPNAVLISVKSRSRVVRKKAGSAVHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXW9</accession>
    <name>A0A3D8SXW9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase M48 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_02274</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="6">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase M48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SXW9"/>
    <dbReference type="OrthoDB" id="7464992at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07331">
        <property type="entry name" value="M48C_Oma1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051156">
        <property type="entry name" value="Mito/Outer_Membr_Metalloprot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22726:SF1">
        <property type="entry name" value="METALLOENDOPEPTIDASE OMA1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="8">
        <location>
            <begin position="155"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW91109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="376" mass="42148" checksum="B2FE0C67F2E26E86" modified="2019-01-16" version="1">MFSSRIPKIPSIRRALPRQAPSLAPRAFPAAQPRTPSCPSSVRNYAFRHRDDPPRRAGRVLRYDPQRVHGAKPLITVEQLQNFGRSPQTKIIVVVIAGAGAIFYYSNLETVPVSGRRRFNCYSEASVEQEGQLLYQKIMMDAQQQGALVPSWDRRSKMVERVMQRLIPASGLEHVNWEVHVIRSNEKNAFVIPGGKVFVYSGILPICQNDDGLATVLSHEISHNLAQHQAEQMSSMVLFTPFRYLFTVIGASLGLYGLGQFLGDLALDLGFARPASRQQESEADYIGLMMMAKACYDPRAAVGLWQRMAQAQADEPPEWVSTHPSNETRVAQMMKWLDKAEEERMESGCATTFGYQRDFKTVIDSLGGGLGDAFWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SY38</accession>
    <name>A0A3D8SY38_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02412</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SY38"/>
    <dbReference type="OrthoDB" id="5314997at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="1">
        <location>
            <begin position="4"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="287" mass="33187" checksum="71B4C4441464C5CB" modified="2019-01-16" version="1">MLHFLEDLPREIRDKIYAYVLASPSGCITLARGKYKQKHSYRIQPHYPTSGTTHCHPDNAIGLQLLKTCKQIYEESRDILWQLNTYGIDTSWDLADFSMCPPLLVGQSIRSLEFGIHYPTGSEFAKGLKVQRMEKIFERFGEWSEHGSLAAVRLHLVQDFDKVMLLGRISPINSSIVRSHRFFLAALTTARTVSLRNVHRDLALKSSWPRLTAEQRMLWTKVQNAKEDNPHWVFTPNRFLRDVHSAWGGELWLDGELCARNGRTIRKPFWLLSPQVKVQPEIPRPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYX1</accession>
    <name>A0A3D8SYX1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14 15">Diphosphomevalonate decarboxylase</fullName>
            <ecNumber evidence="3 14 15">4.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BP5796_02661</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(R)-5-diphosphomevalonate + ATP = isopentenyl diphosphate + ADP + phosphate + CO2</text>
            <dbReference type="Rhea" id="RHEA:23732"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57557"/>
            <dbReference type="ChEBI" id="CHEBI:128769"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.1.1.33"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:23733"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 15">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 3/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14 15">Belongs to the diphosphomevalonate decarboxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.33" evidence="3 14 15"/>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYX1"/>
    <dbReference type="OrthoDB" id="10253702at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00100"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004163">
        <property type="term" value="F:diphosphomevalonate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000018">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000005">
        <property type="entry name" value="Diphosphomevalonate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005935">
        <property type="entry name" value="Mev_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029765">
        <property type="entry name" value="Mev_diP_decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053859">
        <property type="entry name" value="MVD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041431">
        <property type="entry name" value="Mvd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01240">
        <property type="entry name" value="mevDPdecarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10977:SF3">
        <property type="entry name" value="DIPHOSPHOMEVALONATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18376">
        <property type="entry name" value="MDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22700">
        <property type="entry name" value="MVD-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015950">
        <property type="entry name" value="Mev_P_decrbx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 15" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14 15" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14 15" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="11 15" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="8 15" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="10 15" id="KW-1207">Sterol metabolism</keyword>
    <feature type="domain" description="Diphosphomevalonate decarboxylase-like N-terminal" evidence="17">
        <location>
            <begin position="13"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Mvd1 C-terminal" evidence="16">
        <location>
            <begin position="198"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR015950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF22700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDW91496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="394" mass="42179" checksum="D81FF1BE4FE2150F" modified="2019-01-16" version="1">MTDSKIYQASTTAPVNIAVVKYWGKRDAKLNLPTNSSVSVTLSQKDLRTHTTAACSATFPSEDTLLLNGSPQDVSGARTQACFRELRALRSALEAQDSSLPKLAALPLRVVSENNFPTAAGLASSAAGFAALVRAIANLYELPSSPTDLSRIARQGSGSACRSLFGGYVAWQMGNEVDGSDSVAVEVAPTSHWPTMRALILVVSAEKKGVSSTSGMQITVATSELFQRRAEVVVPKHMELMEKAIKEKDFETFAKVTMMESNSFHATCLDTYPPIFYLNDVSRAAIRVVEDINAAAGKTIAAYTFDAGPNAVIYFEEKDLDAVAGPLKSALSGLDGWQAAEREIKVQGLDKVDERAVKVLKDGVSRIILTSVGEGPIKTEESLLKADGTALRQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZ39</accession>
    <name>A0A3D8SZ39_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">propanoyl-CoA C-acyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.176</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Propanoyl-CoA C-acyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_02758</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.176" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZ39"/>
    <dbReference type="OrthoDB" id="542135at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00829">
        <property type="entry name" value="SCP-x_thiolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000016">
        <property type="entry name" value="Non-specific lipid-transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020615">
        <property type="entry name" value="Thiolase_acyl_enz_int_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055140">
        <property type="entry name" value="Thiolase_C_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020613">
        <property type="entry name" value="Thiolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020616">
        <property type="entry name" value="Thiolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006102">
        <property type="entry name" value="PRK08256.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870">
        <property type="entry name" value="ACETYL-COA C-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42870:SF1">
        <property type="entry name" value="NON-SPECIFIC LIPID-TRANSFER PROTEIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22691">
        <property type="entry name" value="Thiolase_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00108">
        <property type="entry name" value="Thiolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00098">
        <property type="entry name" value="THIOLASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00737">
        <property type="entry name" value="THIOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Thiolase N-terminal" evidence="10">
        <location>
            <begin position="11"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Thiolase C-terminal" evidence="11">
        <location>
            <begin position="266"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW91593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="460" mass="49678" checksum="B19348C8371970A5" modified="2019-01-16" version="1">MVIKRSEPSYVLGVGMTKFIKPRGKVDYTELGFEAGVKAMLDAQINYDDVDQGVACYCYGDSTCGQRVFYQFGMTQIPIYNVNNNCSTGSTGLAMARNIISHGGADCMLVVGFEKMMPGSLQSFWNDRSNPTGTTLEMMQQTRGITNAPGAAQMFGNAGREYMEKYGAKSADFAEIARINHEHSQRNPYSQFKDVYTLEQIEKSPMIFEPLTKLQCCPTSDGGAAAVLVSQDFLDARPHLKDQAILIAGQCIATDAPSLFSRSAIDLMGFEMSKYACQTAMNEAKTEPKDVSVCELHDCFSANEMITIDALGLCPPGKAHEMVRAGDITYGGKRNLVINPSGGLISKGHPLGASGIAQCAELVWHLRGWANNRLVKNTSVALQHNLGLGGAVVVTVYKRADGKSAESVSSEAIAKKTGLGYNPAVEAKGFTEQQAASVKSKTKSSVWALADTQTKVQARF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZ69</accession>
    <name>A0A3D8SZ69_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_02714</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZ69"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="23"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW91549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="325" mass="36185" checksum="E2570DACF51F5349" modified="2019-01-16" version="1">MRLINTKSLELSEFTAEKSPAWAILSHTWEAGEISQAEWNEIQEQPNSDYLREKAGYIKIKKLCSLCQGGISICRHADCTDTVCELPESSNCCLKMDQICQCEPLVIEWAWVDTCCIDKSSSAELSEAINSMFNWYRSAAVCIAYLGDVPGDDDVAGESSAFRKSRWFTRGWTLQELIAPIGHGVNFYSVDWEFLGSTTFTQRLLNNRLANQGLAQQVPHIELQDQGELGDNLSEAESNGADTEVRLDGSQIEIGLNDQQTESEPNRNTLPQAPNKSQTQGPPGKRSDRHLTIFLHRLKPSRQQSQMKSNPTIARHPGGVPPASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZE0</accession>
    <name>A0A3D8SZE0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_02858</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZE0"/>
    <dbReference type="OrthoDB" id="3562400at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055496">
        <property type="entry name" value="DUF7068"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46844">
        <property type="entry name" value="SLR5058 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46844:SF1">
        <property type="entry name" value="SLR5058 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23238">
        <property type="entry name" value="DUF7068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="452"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW91693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1223" mass="139491" checksum="A2536BF2EC876982" modified="2019-01-16" version="1">MELIIIISTLILLVAGLIIVNLEHRTKVANTRLAADPRAESQQAHEPDQTLPPQRGVHLRQVYPDETRETETDIDIIAIHGLDTKSPETWTWVDQKNPTIRVNWLQDQAMLPSTVDRVRIFTCDWPADLLQPSNLIQMEFLELALLLSEGIQRRPPVSSDGASRDRPILFIASCLGGIMLIKALVDAGKQDHPLRRATRGIIFLATPFRGTSFEEVAIWAVPCMEAWALVQRREVTKLLASVKGLDLDALVRNFTQLNQQQDPPCEVFNFYEKRVTSLPSKIFPWLPTRLRQEKLLVNRVSATLDMVPNPLSLDQPHVLMNKFKGPECPGYKLVVGQVQRILGMIREGSLLEQADVWIREKHYTEDRLKIDRLSGERLMMEQCYINLAIVEQPRGNAASSGGPGNQEISPLSSHSSLRARLRIETPAKDVQVELHTIFDQRRRPDGLIAQPKRIMIRGQAGVGKTTLCKKIIHDFQRGRYDIFDRILWMPLRRLKTWNADKYTLGQLFHHEYFPGTPNGERLSEALWRDIYAVNGKKTLFILDGLDEVAGILDPESNKHQLLITLLNQPNVIITCRPHGAFVSNLHPVSLELETVGFYPDQMNDYIEMALQKRPRHEIDEVQSFLEDHFLVQDLMRIPIQLDALCYTWDNRDYRIDPQLQTMTAIYQAIEHSLWKKDIVRLGKKDRGDPVTSSQIQSSSAPTIERLVRDEILFLEGLAFTGIYSDVINFDTKQLGYMYETFKPENDFLLDKTLPNLSFLRTSDQSSEYKDQNYHFLHLTIQEYFAARYFVRCWKSGNEVICLKLNTGGSLQKECPAANYLQERKYNARYDIFWRFVTGLLQGKGSDAQLPRFFYTIEKEPRDLLGPVHQRLVMHCLSEVVMQKEPPTFTPLRKQLEMRLSQWVLFECNFTRYGSQLAGEIELPEQVLNKILPQRSKDISDTQIQILNSLPKRKTQPLSIIRLANDSLTQSDVSPELKISSIHILGNLYRVSSSDIRAIVALLKNEDPFVRRAVGDALAKQPALSPEVLEAIQPALSPEVLEAIVALLKDEDWLVRRAVVDALTKQPALSPEVLEAIVALLKDKYPSVRRAVVDALAKQPALSPEVLEAIVALLKDEDSFLREAVVDALAKQPALKSELIGENIESFYRSWVERSFVTHTSWYIVNGVSYVDMPHGRLQFEGKEDRLRGLIREAQQRLCLENGGLNGLWTYMTEDGSNSISTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZR5</accession>
    <name>A0A3D8SZR5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_01164</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyl hydrolase 18 family. Chitinase class III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZR5"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02877">
        <property type="entry name" value="GH18_hevamine_XipI_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045321">
        <property type="entry name" value="Cts1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="3" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="7 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017654860" description="chitinase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="13">
        <location>
            <begin position="32"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="343"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW91770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="385" mass="40049" checksum="E5168037C1CF34CA" modified="2019-01-16" version="1">MYLRTILAKLSLLASIVSAAPLQLLSRQAPGAQNVVYWGQNGGGTIENNDLSTYCTSQSGIDIIVLAFLYEFGNGNTIASGTIGQSCYISPAGEPQQCDALATAIETCKANGVKVMISLGGAASAWSLLSAAEAQTIGQNLWEAYGNTAAGSTPRPFGSTFVDGFDFDLESNSGNEYFQYMISTLRSNFASDPGNTYYITGAPQCPIPEPNMGEIISAAQFDYLWVQFYNNNPVCSLGFNGNAAFNFDAWVSFIATTPSAGAKIFIGAPAAPLAANGGVSGEVYYIPPTDLATLVNEYKSNAAFGGVMLWAAGFSDSNIIDGCTFAQEVHEILLTGSPASSCSGTGTLTTTVTSTPTPTTSPTGTSPPTTTVTGTVGAYDQVSPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T081</accession>
    <name>A0A3D8T081_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">histidinol-phosphate transaminase</fullName>
            <ecNumber evidence="4">2.6.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Imidazole acetol-phosphate transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_01303</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:23744"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57766"/>
            <dbReference type="ChEBI" id="CHEBI:57980"/>
            <dbReference type="EC" id="2.6.1.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 7/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.9" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T081"/>
    <dbReference type="OrthoDB" id="2015537at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004400">
        <property type="term" value="F:histidinol-phosphate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01023">
        <property type="entry name" value="HisC_aminotrans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005861">
        <property type="entry name" value="HisP_aminotrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01141">
        <property type="entry name" value="hisC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885:SF2">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42885">
        <property type="entry name" value="HISTIDINOL-PHOSPHATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="12">
        <location>
            <begin position="38"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW91909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="425" mass="45779" checksum="47A4B3F044236619" modified="2019-01-16" version="1">MPEKKSSFNLSTCARANILALQPYRCARDDYKDDGTNILLDANENAYGPSIPSSITSSTTSSIDFLGLNRYPDPHQHELKQLLCNLRNTHVHTPKNITPENLFVGVGSDEAIDALLRCFCIPGRDKILVCPPTYGMYSVSAQVNDVGLVKVPLLPAPKFGLDVEGISSVLSSPEGEVTKLVYICSPGNPTGSLIAKEDIQRLLEHPTWNGVIIVDEAYIDFAPSGSSLAEWVAEFPNLVVMQTLSKAFGLAGIRLGAAFTSPEIAALLNNLKAPYSISSPTSYIASQALSPEGLAVMASNLSKIIAQRDRLLTSLPKVPGIGRFRGGIASNFLLVEILNQAGNPCNETALAVYESLAGKRGVVVRFRGKEVGCEGCLRITVGTEEEVGRFLTEAERVIAEVWKSGKELNSSEEEERERSANGVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0B8</accession>
    <name>A0A3D8T0B8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_01265</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0B8"/>
    <dbReference type="OrthoDB" id="5404651at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF8">
        <property type="entry name" value="NUCLEAR MRNA EXPORT PROTEIN THP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW91871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="552" mass="61537" checksum="C4A30D6B4E5D31D8" modified="2019-01-16" version="1">MAIIEEFLASIHAFIKTKDALKLQDWLRVEPPLPEHYYKLGAELKAKYKDGNVLERYIEKLLPENANAKADEGDVWPGFLAFMKAYLEFWRDVDFEDLLRTHTQLSELVNSCITALSNATYGIVVLPTVIQLSAALAKLAMTLDKRPDLTRNRRAVVDQGGEGRKTLVEGTAESIQRAFTMCLTERTSNRNGIGKDGKPEGKKVGIYSFANLVLKLLFQCRKTRLANQLFTNISQNSPPLSLYPASQRVTYLYYLGRFQFANGHFYHAQICLQSSYDQCHAQCISQRRMILIYLIASNLILGRFPSPALMSRPEAQGIVDKFFPVAKAIKKGDFVAFKRSLGPESGNEEWFFQKGVLLPMLYRCEVLVWRSLARRVFLLTYQAPGDVNSRKAPTLDFTDFAAAAQYCQMMLEMSGKSTPFNNRQHVNTMFMKPTEQSIPERRKLSAASGVICGNHTPDVKEVEAIVASLVQQGLLHGFISHNQGKFAILGAKQRGGAVNAGFPGVWDVLKTKAAREGKNTQIPGWVLRERQVGGMGGVVNLSGIARPVGSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0X1</accession>
    <name>A0A3D8T0X1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_01616</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0X1"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07216">
        <property type="entry name" value="Pat17_PNPLA8_PNPLA9_like3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF4">
        <property type="entry name" value="SERINE HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G07870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="4">
        <location>
            <begin position="23"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="160"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="454"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="544"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="27"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="494"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW92222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="610" mass="67721" checksum="FC197D9820D5DEF7" modified="2019-01-16" version="1">MDNNNDGALRRKDTTKGPPLRILSLDGGGVRGYSMLIIVQELMHRTFVEIEGRAPRRQEIPKPCDHFDLICGTGTGGLIAIMLGRLRLDLETCKEVYVRMTRKVFETDKTIAGIPYRSTLFKASKLEEAIRECVREHTVYEREGNDGEEADMTSPMSPFNRSGVPQRHTSNASVASFSARSPQSYTSRPMMGLRWGNPNAALYDSRENRTKTAVTAIYKGTPKNGAPAILRSYDSRKEPSPEFNCTIWQAGRATSATGLAFKPITVGQSVFIDEGAGQYNPAPFVLDEAVVNEWPGREVGVFVSIGTGKRPAGSDHNQHLWYEGFMGDFAEARRRLISKIEGCEETHQYMKREYLSKRGVNIENYYRLNVEIGVGEFGMNEWNRLADISTGTRRYLGKSEIQNMNHDAAVKLAKIHRAKARFERGEATAATGEYKYLQDVPEAYPNAIELPAEVPDMPAQPQRTPPPRPSYESYESGHHDTLEVPRKHKTPSPRSSNENQAQQQAQPPPRSSPKIQDDRFVVNAPTPSQYRTAGGADKIAIINQEDHPGAQISGGRAMVGGRVEPPPLPPKTPINMTTGGRGRTMLAPYPLDDGPPPAANMARKPDYRGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1M3</accession>
    <name>A0A3D8T1M3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal recognition particle receptor subunit alpha homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Docking protein alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_01871</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1M3"/>
    <dbReference type="OrthoDB" id="1727884at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005785">
        <property type="term" value="C:signal recognition particle receptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14826">
        <property type="entry name" value="SR_alpha_SRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17876">
        <property type="entry name" value="SRalpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000566">
        <property type="entry name" value="Signal recognition particle receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.140:FF:000009">
        <property type="entry name" value="Signal sequence receptor alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000023">
        <property type="entry name" value="Signal sequence receptor alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007222">
        <property type="entry name" value="Sig_recog_particle_rcpt_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF1">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04086">
        <property type="entry name" value="SRP-alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="12">
        <location>
            <begin position="636"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="158"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="175"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="242"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00071429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00081194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW92477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="666" mass="72093" checksum="D1DD9CF0CE06E59B" modified="2019-01-16" version="1">MLDTFEILTTSGVVLWSRSFSTISPAIINGLITNVFIEERTLPGAGIADDVSAANNPPYKHDQHTVKWTTSKELGVIFVAVYRSLLHLSWIDKLVDNIKTLFVDLYGDQLRKPHTTVVKCHFDEYFDQQLQELEKSAINKDIKVAESTAFLEKAPASVAGELRDEPPPLPGLLSRGQSKNNYNDLTSNDSSPARTPSGSRPSTPAGHLLTGKANPGGKTSRRARKAANTPTYASSGEESGAKKNRAAKAAAPKKGRRWDADGLADEDSDTPLDYSTHANDATSGEEDGTTRPGGMEEVDQETWGSRTKKGQFVLKDLDDQVHSILSSADTKKVGSATSGGLVGSSISAIGGLFRNVVGGKELTKEDLDKDLKVVEDHLLRKNVAREAAIRLCEGVERELIGVKTGSFESPQARIQTAMEASLKKILTPTSSLDLLREIDAVTSPSSLSLTKRRPYVISIVGVNGVGKSTNLSKICFFLLQNKYKVLVVACDTFRSGAVEQLAVHVRNLKELTTREGGVVELYQKGYGKDAANVAKDAVAFGAQEGFDVVLIDTAGRRHNDQRLMSSLEKFAKFAQPDKILMVGEALVGTDSVAQARNFDAAFGAGRRLDGFIISKCDTVGDMVGTLVSMVHATNVPVLFVGVGQHYNDLRTFSVKWAVEKLLDIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T2B2</accession>
    <name>A0A3D8T2B2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative long-chain-fatty-acid-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_01532</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:15421"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57560"/>
            <dbReference type="ChEBI" id="CHEBI:83139"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T2B2"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035336">
        <property type="term" value="P:long-chain fatty-acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17639">
        <property type="entry name" value="LC_FACS_euk1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF83">
        <property type="entry name" value="ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="6">
        <location>
            <begin position="105"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW92138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="693" mass="76493" checksum="2E73B70347516A5D" modified="2019-01-16" version="1">MSLKNIVVQPRMYHKPPFSLEAPGYEPVEGETIPRRNPDTVNELQNTPSKDVTTIYDIIKRSSEKYGNAKALGTRKLIKTHQETKKVKKMVDGKEEEVDKKWTYFELSGYSYLSFQDYEKLVMQLGAGFRKIGMKKEDRVHIFAATSAHWLAISHGAVTQSMPIVTAYDTLGEEGLKHSLVATGAKAIFLDPHLLPTLINPLKEAKEIKYVIWNSQNEVKQENIDSLKKAHGHLEIMSFEELRKLGETNPVEPVPPSPKDLCCIMYTSGSTGPPKGVPLKHEAVVAAIAGVSVIVEKYLGPGDGLLTYLPLAHILEFVFENACLYWGGTMGYGNPKTLSDASVRNCKGDIREFRPTVLVGVPAVWESVKKGIVAKVNSGSPIVKNLFWGAMWAKANLLHYGLPGAEILDSIVFKKVKEATGGRLRICLNGGGPIAKETQRFISMAITPMISGYGLTETTAMGALMDPMEWTDDALGNIPGSIEIKLVDFPDAGYFAKNKPNPQGEIWIRGVSVMEGYWQNEKETAEALTKDGWFKTGDIGEWDKNGHLKIIDRKKNLVKTQNGEYIALEKLESIYRSATVVANICVYADEQKTRPIALIVPAEPALKKLAESIGVEGSGLEDLVHNKKIQDAVLKELQDKGRSGGLSGIEIIEGVVLADEEWTPANGLTTSAQKLNRKAILTKYKKEVEQAYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T3R3</accession>
    <name>A0A3D8T3R3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GTP cyclohydrolase II</fullName>
            <ecNumber evidence="3">3.5.4.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_02032</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 2 phosphate + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23704"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58614"/>
            <dbReference type="EC" id="3.5.4.25"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; riboflavin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP cyclohydrolase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.25" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T3R3"/>
    <dbReference type="OrthoDB" id="5569761at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003935">
        <property type="term" value="F:GTP cyclohydrolase II activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00641">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10990">
        <property type="entry name" value="GTP cyclohydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032677">
        <property type="entry name" value="GTP_cyclohydro_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000926">
        <property type="entry name" value="RibA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036144">
        <property type="entry name" value="RibA-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001591">
        <property type="entry name" value="PRK00393.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00505">
        <property type="entry name" value="ribA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF29">
        <property type="entry name" value="GTP CYCLOHYDROLASE-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00925">
        <property type="entry name" value="GTP_cyclohydro2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142695">
        <property type="entry name" value="RibA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="GTP cyclohydrolase II" evidence="9">
        <location>
            <begin position="68"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW92638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="330" mass="36906" checksum="1A0B46520D7203BB" modified="2019-01-16" version="1">MAHLRPLSMLCRSQLPRTVFRSRGAIRHHASIAESRPSIRVSSNIPRSANLNPLQQSVSKSLPYVKCVVRARIPTTAGGEMFLHLYENSMDKKEHLAIVFGNTIRSKSLDQQMDSESEMDRMIRGAYKGTLYPGRHTSHMLEDTILGDSLPPLYEDDESAPLVRIHSECYTGETAWSARCDCGEQLDEAANLMSNSEKGGIIIYLRQEGRGIGLAEKLKAYNLQDLGSDTVEANLLLNHPADARNYDVATAMLADLGQKDIRLLTNNPDKVRAIEGPNHEIVVQERVPMVPLAWKTHGGIKSVEVERYLKTKVDKMSHMLTTPIMNHLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T723</accession>
    <name>A0A3D8T723_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VPS9 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_00120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0507 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030133">
        <property type="term" value="C:transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097422">
        <property type="term" value="C:tubular endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000443">
        <property type="entry name" value="Putative vps9 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.80:FF:000009">
        <property type="entry name" value="VPS9 domain protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051248">
        <property type="entry name" value="UPF0507/Ank_repeat_27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24170:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G09870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="3">
        <location>
            <begin position="349"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="551"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="174"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="577"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW94357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1306" mass="146060" checksum="5B38043F6A132307" modified="2019-01-16" version="1">MQPLNPFLSSFFKSALPTQCTPVHHHILLVPTTECLLTSRDRESGALYADLAGSEDFLGSHVLRVPANIAATAGGKDAPNMRESRGKAKQYTTVNGKTVVIKDAYVYSNKGFKTLNQAQMLSDTLWYPDSLEPRQWLVYYISRPLVGIFEEVIIVPAVLQPRLPDGRPVLPPRSASQTSSATTTLPRKKDIKSFNDLLTNFPMIARQMQPGLEQLFKEFNAAFDKPLPPPPSAAVIPDPVPDGPIITAMKKARSNSSSSAPRLQANGHTEAQDIENFYAEDDEDVMRGALETAVTTAIDLFQQVDKQQLSLLGATTDLTGPVVERLIERYVTEQVHDSVLYPRVCAMKRPEDLELEAKIRQMEFIDISQVGIPIPGGQRGKHELTLRLGRAVEEFRKLGVAGSPQQMMDILLLTLKTVTQLAEVPSPNTGIDGTERLSSVLTINADTLVSLLLIVVIRAQVRYLQARLLYMHNFIYIDDVESGEMGYALSTFEAVLSYLDRDSGGLRRASRRNHKLWQATRNGEIKEMMRILEPDREHSSDDDDEIADEEALEDDLDDERRPWEYTNGNGLARRSSRSSTRSSQASTLNHVFPFQIQHTEDIEELPAPRGRKTVTMDTRSLSSSSEISFRSRATTIDSMTSGIEGDTSVARLAQTEDSFGESIPMMAVQYERPNSLQYLLSLKEYYPLDVIIGDTNNEGTTLLSAAVQIGHTELIDVILDFIYRVESQELVVQYLSRQDVRGRSVAHYLFNAPALIPRVGRLLPWRQKDKNGQTPVFALCRSYDHSNYRAMVEAGLSAATISQGDGEPLHLDDHVDFKGNTLLHIVNDPQVAVRLLLHCDSDANATNEKKFTPLMVASKYGRLDMVRALFGDPRVDLFAKELRGLTAVELAKDDEVRNRIDDLILFAGRPAADGRITSVVRSFFVEDATIRLVVKSGAPSMHQSFTVTTCRRSLADFEHLAKLLSIENPASWLPTISGMRSPFQFPSRPSRAVLRDIQLRLDSFLKILLAHSTFSTHEMLWEFFLVPDIQAEMMDQRSKLKAETRVETVREEYEPIEDIRDVEQFVDHARDMVRSVNYSTKSVARRTNMVKTASTDLYAAAYLASRALSTVEFLPPSHTSAFAAYVTTLASTTTSPYTNFHTAFLSIHSTIIAMLLALSRPTSLISSITTSRKSIERSYNSLSRSTRWPLGLLDETRQRLNEEKEEKVKRGKEEVIEAGKELRYTQQVVASELAGWQDLHEKMGRKAIRDLARGMVIKERTALEGMRRALRKLRIGEVIDLPSPATKANETETAIVDEAAVVNGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7T8</accession>
    <name>A0A3D8T7T8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">p-loop containing nucleoside triphosphate hydrolase-11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_00390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7T8"/>
    <dbReference type="OrthoDB" id="6585768at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090068">
        <property type="term" value="P:positive regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd04128">
        <property type="entry name" value="Spg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000330">
        <property type="entry name" value="Septum-promoting GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017231">
        <property type="entry name" value="Small_GTPase_Tem1/Spg1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW94627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="304" mass="33528" checksum="14186C791E018C05" modified="2019-01-16" version="1">MDAEGVYEQPVEGHPQDDAMAEGEGSSTPTHDLPPSQHGQSQSADFPSSQQGYSGSPNPEADPNGRYPTPPTAFAPSISRPNSGLSGNGAYPPYQEQNARSAQGSETGRNKNSVVIKVGMVGDAQIGKTSLMVKYVEGSWDEDYIQTLGVNFMEKTISIRNTEITFSIWDLGGQREFVNMLPLVCNDAVAILFMFDLTRKSTLNSIKEWYRQGRGFNKTAIPFLVGTKYDHFVNFPREDQEEISNQARRFAKAMRASLIFSSTSHSINVQKIFKIVLSKAFDLKCTIPEIENVGEPLLLYQSVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8A3</accession>
    <name>A0A3D8T8A3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_00518</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8A3"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF24">
        <property type="entry name" value="HYPOTHETICAL FRUCTOSYL AMINE:OXYGEN OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="9"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW94755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="435" mass="48236" checksum="50A0C88AFFD03D4C" modified="2019-01-16" version="1">MAPSKDASILVVGAGTFGCSTALHLARRGYTNVTVLDPYELPSPISAGNDVNKIIEEGSPDSDDGSNYVSQRILQVAYEGWIKDPVFKPYFHNTGFIIAAHTPAGLEQLTKREMVHKKSEYEWLDNAAEFKKTMPEGVLTGDFPNWKGGWKKEGAGWVFARGALMSAFREAQSLGVKFVTGDPGNVTKLMEEGGDIVGVETKDGKQHQADLTILAAGANAPQLLDMKDQLRPTAWTLAHIKMTEEECKLYKDLPVLFNLESGFFMEPDAERGELKICDEHPGYCNWSTTPSGHRQSVPFAKQQVPLESEARVREFLSHTMPHLSSRPLVFARICWCADTPDRNFLISHHPDYKSLVLAVGGSGHGFMHITSVGGFVVDLLEGGLESRLREAFKWRPETAVDRDWENVQGRRGGPNKVMNFGDVGEDEWTNLESRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9J4</accession>
    <name>A0A3D8T9J4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Cysteine synthase 1</fullName>
            <ecNumber evidence="5">2.5.1.47</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">O-acetylserine (thiol)-lyase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">O-acetylserine sulfhydrylase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">O-succinylserine sulfhydrylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BP5796_00950</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of O-succinyl-L-serine into cysteine, the last step in the cysteine biosynthesis pathway. Can also use O-acetyl-L-serine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate</text>
            <dbReference type="Rhea" id="RHEA:14829"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:58340"/>
            <dbReference type="EC" id="2.5.1.47"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-succinyl-L-serine + hydrogen sulfide = L-cysteine + succinate</text>
            <dbReference type="Rhea" id="RHEA:53816"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:136856"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-cysteine biosynthesis; L-cysteine from L-serine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cysteine synthase/cystathionine beta-synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.47" evidence="5"/>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9J4"/>
    <dbReference type="OrthoDB" id="10259545at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004124">
        <property type="term" value="F:cysteine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006535">
        <property type="term" value="P:cysteine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01561">
        <property type="entry name" value="CBS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000011">
        <property type="entry name" value="Cysteine synthase (o-acetylserine)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000049">
        <property type="entry name" value="Cysteine synthase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050214">
        <property type="entry name" value="Cys_Synth/Cystath_Beta-Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001216">
        <property type="entry name" value="P-phosphate_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007989">
        <property type="entry name" value="PRK10717.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10314">
        <property type="entry name" value="CYSTATHIONINE BETA-SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00901">
        <property type="entry name" value="CYS_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0198">Cysteine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="19">
        <location>
            <begin position="44"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00050981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00058228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00072087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00078262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00079147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00081847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RDW95187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="377" mass="40499" checksum="5596D2225988107F" modified="2019-01-16" version="1">MFRTGVRRFGTTAWRAAQTAAQMEAPNQYGIGVSKAQGVVKGLTGAIGNTPLIRLNHISDATGCEVLGKAEFMNPGGSIKDRAALYVVKDAEEKGLLKPGGTVVEGTAGNTGIGLAHVCRSKGYKLVIYMPNTQSQGKIDLLRLLGAEVYPVPAVAFDNPENYNHQAKRHADRLENAVWTNQFDNIANRKAHIETTGPEIWAQTNGKVDAFTCATGTGGTLAGITRYLKTVSDGKVKCYLADPPGSVLHSYISSGGKLVERSGSSITEGIGQGRVTDNLQPDIDLLDGSMHISDEKSIEMIYRCLDEEGLYLGASSCLNVVAAKEVAETLGKGHTVVTVLCDGAYRYADRLFSKKWLSDKKLLGSIPKHLEKYIVLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q374</accession>
    <name>A0A3D8Q374_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative nitrilase-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_13237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000029">
        <property type="protein sequence ID" value="RDW56362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q374"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF1">
        <property type="entry name" value="CN HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="7"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW56362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="302" mass="33362" checksum="0B77EFF7E3EAD1F9" modified="2019-01-16" version="1">MSKPKTLQVAAIQASPVAFDLKLSLDKLQKLTAEAALAGAELVVFPEAFLSAYPWRYAFDATIGTREPRGRIWYAKYYDSAVAIPSPEFDILRDTAERNKVILHVGIIEKEGGTLYCTAVLIGKDGKLLSHHRKLIPTAAERLVWGRGAGDGIQVVDTEFGKMGGLICMENYMPAARLALYQLGIEIYIAPHADDLPAWVASMQHIAKEGRCFMISVNQFCRVSDFPADYPPFTADHHDRSPAGSKWVPDDILNHGGSCIVGPLGTFIAEPVWDKEETIHATLNLPDLTEARASYMEYLNQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q3F9</accession>
    <name>A0A3D8Q3F9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_13180</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="PDLN01000027">
        <property type="protein sequence ID" value="RDW56431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q3F9"/>
    <dbReference type="OrthoDB" id="5589195at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042281">
        <property type="term" value="F:dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF1">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="471"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="500"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="535"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW56431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="580" mass="65858" checksum="AF77BC155B3AA7FC" modified="2019-01-16" version="1">MSSPHKPRRKPKKQLGAEGAASSATPNFPLEAFLWPARGFVSQWEILPLILMAVGLFRWAAGLWGYSGFQNPPMHGDYEAQRHWMEITIGLPISQWYFHDLEWWGLDYPPLTAYHSWLLGKIGSLIDPAWFALRSSRGIEDPALKVFMRATVIVSEYFIYIPAAVIFVRRFTRLQGINHWHAWIALTAILMQPGTILIDHVHFQYNTVMLGFVLACMSSIQAGRYMWCSVFFVMALGFKQMALYYAPAIFAFLLGVCIFPRINLARFLGIATVTAVSFAVLILPLYLGALYDSYRGIDARPELFGHKAPLPLFTEHSFRLDHNAWYYPILQQTAQLIHRVFPFARGLFEDKVANFWCTLNILIKLRKYPSELLQRASLLLTLTAITPPCFVIFVKPKKELLPLALATTAWAFFLFSFQVHEKSVLLPLMPMTMLLTGKNGLSDNIRSWVGFANLLGVWTMFPLLQRVDLRIPYYVLSLLWAYLLGLPPTSFAAYKTGWSTWTGCAMSTMHLLFYAFMAVWHVVEATLSPPATKPDLWVVANVGVGSIGFGICYLWCLWTLVAESKLLSFLGTQPKKAKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q492</accession>
    <name>A0A3D8Q492_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trichothecene 3-o-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_13107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000025">
        <property type="protein sequence ID" value="RDW56642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q492"/>
    <dbReference type="OrthoDB" id="671439at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF310">
        <property type="entry name" value="FATTY ALCOHOL:CAFFEOYL-COA ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW56642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="495" mass="54555" checksum="4E7C01D55329BD4C" modified="2019-01-16" version="1">MANRREIRVGPVGDAIEGKDEIFQLSDLDHLMPKLYVHMIEIFELPEDTDKTSIINNLVTGLERTLSDYPILTGTLHFDNEARRIVVKKQPGSSVALHIKEAGDEDIPPFSMLDEHDFPVHLLDAPKVLPPLFVAEHWNPIPGNDISSEGPAVAGAQVTFIRGGVILGLAIPHQVCDGPGFEALLTVWARYAAAATTGADYSKLADTGSQINSRSILTAKTKPTLSPEELQKLGDKFPTMKLRDGPSAPPPADFKMPVVKTRIWHFPQSKLLKLKSQCSAKLEPGTWISTYDAILAMMWRATVRAKSPLLKPNPDAPSKTIHAVNGRSRAVPPISDRYIGTAITLPQSKNLTVAEVLGDLETTLPILARTVRASTSSITPEYLDGLVRFAAGSHDLRWAELDMNWILGLDCMAFDWHTMKSYQDHDFGFGGPAALRWPHPGFEGFFFVLPTRANVRNAGKDEGIEVCFGLEENCYAELEKDEEFAMYAEQRGLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q4I8</accession>
    <name>A0A3D8Q4I8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_13072</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000025">
        <property type="protein sequence ID" value="RDW56607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q4I8"/>
    <dbReference type="OrthoDB" id="5429740at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF146">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="34"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW56607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="325" mass="36362" checksum="4055ADC297054436" modified="2019-01-16" version="1">MEIPQPSEGDIDIGRPMMVIIWTLYGITIVVVAIRLYVQARITRRLGLGDAMMVLSVASGLGLCALLTVQRHYGLGRHFFFLDPHQRIMALKYNFIGQPFGIMGPSFGRMACVMLMLQLFGTTKWRRRGLWFLFWESLVVNTITIVLIYVQCEHVQSLWDPIGHPGRCWSPKVQEIVGFVQGGLNSAVDLVLTIMPATIFWKLQISTRLKVGLVILLGLSIFAFVACVIKTVLLQALGDRGDFTFNTVSFFIWVVVEGALVSIAASVPLIRPLFLRIKRGKSSKDNKSYEMHPYTHSSRYVAGASIKGAQLLRSIDEDGINNDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q4X4</accession>
    <name>A0A3D8Q4X4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_12930</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000024">
        <property type="protein sequence ID" value="RDW56863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q4X4"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF92">
        <property type="entry name" value="AGL026WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="53"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW56863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="509" mass="55383" checksum="DDEDDE90A95C78FC" modified="2019-01-16" version="1">MADDKTTAAQVENQRGSAPVPALQEAYNELDCLSPEEYATKEKKLVRKLDLRLMPLLFLMIVMNYLDRNALANARIQGIEKSLHLHGTDFNTAISVLFAGYIALQIPSNMIITRVRPSIYIPSCMIIWGLVSGLTAAVHDFKGLVIVRFFLGFVEAPYFPGALFLLSSWYTRKELALRTSILYGGSLLSGGFGGLVGAGVQEGLNGARGIASWRWLFIIEASITVFIAIISLFVLPDFPHTTKFLSDVEKALATRRLETESGNKDTERGPLLSGVKMAFIDYKVWLLALIIITKTSAGAVTSFIPTLVATLGYSKVNSLLLVAPPYVFATIVALAVSFSSDRMSERCYHVVGPIFFGMVGFIIAATTLNFGARYFSLFLMLGGVYGSYNVALAWISSTLPRPIEKRAAAIALVNTVGNFAQIYSPYLYPSSAGPQYRGAMIANACFCLACVGTTLLLRFCLVRENNTLAVIELQAASDFPGEKATVEELVDVPSPGGPVTFTAGFRYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q7A1</accession>
    <name>A0A3D8Q7A1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12494</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q7A1"/>
    <dbReference type="OrthoDB" id="5372021at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596:SF2">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G17550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="136"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW57693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="524" mass="59017" checksum="C6D453D5C96E645E" modified="2019-01-16" version="1">MLDLFNAAGRLAPSSDNFEINPLCPGLSITILTKAWSAALQSHGVCPFLLRKLETFGESTMDWLQWYIQTAEMKFEKEHDHCTESRCARNNIDTLTYKTQHCVPQFPVMKAARSPEGYYSLAVSTMSPNEMTSCTAISHVWLHGLGSSTEIGIPECQVERIWKAVMKLSCSTRDGCFLSYSESPSHLQKSPPFWIDSLCIPEAKDERRYSILLMRKIYKNSGSVLVIDKEIRKCRVGCAIEGLFAAIIMSDWMQRLWTFQEAFLAKSLVFELQDGFFNLDTSLEEEAGSVFYLELPLPAAVIWASLVRQVMTLRRSGAFDVVSMITNALAERSTSKPEDEALAIAGILNIHPGRLIRENGVDIDPKERMKKLYLLMGNVPWEFPFLTGSTYSDKPFRWAPRSFLSQTFSDHGFSSGLGTAEVREDGLVSEYTICKFEQPVRGNKDMSPMEVTIRETGQIMIFFFREQFASDSSSSFPPDETMSFDAVVMDCKNFMPGQYSEALASGIAVNITRFGDSTDIDLTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q7L3</accession>
    <name>A0A3D8Q7L3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q7L3"/>
    <dbReference type="OrthoDB" id="3501153at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053008">
        <property type="entry name" value="Phomopsin_biosynth_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW57826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="275" mass="31114" checksum="C30C7CD9EF5CF967" modified="2019-01-16" version="1">MVDEKTSVPREQPSLSDPFLLHRVNAHEESSSDLSESAPMLSDCESMTFDNGQTSRKLGLRSPVFWSLLTTATYTLLSIITLIALFRVHRTTDHRGVGHGSTRVNGREFCGTERETALAAGCKFDVLGFAWVPPMCWDESATQSSSQKLRQLAGLTELDLDNFILYFDKNRTQLATIRDFEIGGLGNAGRYPVKTPFYTEPVYHKAHCLHVWELQHSALFKASEGQNDVWVWERARQWEHSLHCNRVIYHDEWDIPGQGALALYPGTGDCILIRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q975</accession>
    <name>A0A3D8Q975_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_12322</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q975"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF26">
        <property type="entry name" value="OS04G0435100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW58392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="530" mass="57222" checksum="5534C113A86B65FC" modified="2019-01-16" version="1">MSNWDPKYFEKDEEKLKELGYKQQLLRNLSPLHSFGISFAVISVQGIIATLFGYGFATGGPGTMAFSWLIVSFFSFLVALSMAEIVSALPTSGGPYFWAATLAPPKYAPLASWITAWFNLLGLVASNTTAAYGIAQLVATAAAVKRPGFDPTNSEDIGICAALLVSWALMNTVGRPFLKHVLYFAIALNSVGILAFAVIVLVKAPTHQPASFVFTSFVDETGPSPNNGWATRASPAYVACIGSYMGLGAFFGYDASAHLAEETLRAAWIAPLGIITAVFLSGVFGFFLIVALLFSIQNLDVFDTSLYENPVLQILIESFGVNGGVALFTLPIMCIWCCGLFLTMSNSRLIWAFSRDHGVPYFFSKINERFMSPVRAVLLTSFLSFLLSFSALSAPIAFTAVTSIASTGVLISYGIPILLKVIYHKDFCLRKGPFQLGYVSRPISLVAVLWVIAACIILCLPTTTPITIQTLNYTPIAFGTLLALAMVVWLSGAMRFFVGPVKNWNATDISNLVSSTTTTTTTTTTTSKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q9F9</accession>
    <name>A0A3D8Q9F9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12413</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q9F9"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW58483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="155" mass="16222" checksum="803AD9950344048C" modified="2019-01-16" version="1">MAIKAATASNTAQLQASYTLLQSGLLTLLLSTLLPSSLSQSLSATSGPQALGSTLILTGLLLRQRNLLDLGDTGVLIVQWGFLGRWITIGSDLGAALFFNSVRGAATLSERGVLMKAAHVIPSIGMALAFAVLALGLWDVGVREEEEGEQRSKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q9K3</accession>
    <name>A0A3D8Q9K3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q9K3"/>
    <dbReference type="OrthoDB" id="3792378at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="558"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW58479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="657" mass="72360" checksum="0EC1A4CD1554EF97" modified="2019-01-16" version="1">MTNLEEPQSLPFMHREEDQHVSKQNEVINIQSLPNDVYYDTKSTGESRSKKWTIYTSIIISSVVVPLIGLTIWLARTEFKERRFNTFSGDVVGGRLTQPQAKAIDVICSAVLAPAIMAALNFFWFAVARVSTVNERHTRKAGLPLAALIGVSQSFSGSYNVFLLNNLRKGRSWRFLMLAGMLLLSALAKTALSNLIAYEAYSHIALPTNVGSLRYLSDLAVNRQLQRIGLTTEATSVFDFSTQQQSSVANQITGLLTGLSFANATSSLTDEAYIGVNATSAAMSSLPSDIVSLNNVPGFRLTVDCTPDTPTMFSVVSSSQYVTKMSATWEYKVAAGYTSNAYDAYFASSIDELQNSYTELYPFAAFLDYNSTEVFLSFMYSGFGIINDTVPVTSSYGDIYTLTQNMTSYGFSSTKATMKLWGLRCWLNRQEGLLNYTRTSSLDWQINASSFSNETRKATSLLTPWQSNLMYRAPQSTVAGIAPALAQSAAKSDSDLAVIGDPLNATDFKILALNYLYASGEAQRMTYEVAATNTSNDEPNFFYDVTGQISEQKYRITYIPIILLIGLLALVIAAALPAAMTMYVSKTLSARTFRDVDAVRLLVDAADGLHEEAKDISNLGLGNGDMEKWVDGCKVEYQQTIVDGETRFKLRPVNKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q9T2</accession>
    <name>A0A3D8Q9T2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Luciferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_12360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q9T2"/>
    <dbReference type="OrthoDB" id="5561043at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF16">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="6">
        <location>
            <begin position="33"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW58430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="520" mass="57396" checksum="1466850C90079A6E" modified="2019-01-16" version="1">MAPKKQLHLNFFDMSCNGSHMGVGMWKIPEDNSKWKDSLDYYIWLAKLAEKGKITGIFFADIYGVHDSYPGQSSDQFRSGATCAQMDPIVWVSAMAAVSKSVSFGITGSTSYINPFVLARTYSTLDHATKGRIAWNIVTSYSNSSAKANGLESIVEHDKRYEKAHEYMDLCYSLWEGSWEEGSKMFDPEKGAYDPDKIHRINFNGKHHKTSAFGATHPSPQRTPVLFQAGASTAGKDFAAKHAEAVFVGGKEPSESLAYVKEVRAAAAAYGRDPNHVKVFPQITPILGRTMEEAQAKYEKYKACVDYKGGMAKLSSYLNIDLSSYPLDEEFVVEPNAKGAQGIHAMMATVKSYAAEKITPRVLAQKMAFCGFAPMPVGTPDMVADVMEDWVNNGDIDGFNVAYVSNPESYEDLVELLVPVLQERGLMWKDYAVPGGTYRENMLRTPGQAFAPKGHASREFTYENLKKFTDKNGDITINRQDILAESSTEEKKEVVDLSAAADALTLNKKPETVEVAAVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QB99</accession>
    <name>A0A3D8QB99_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_11963</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QB99"/>
    <dbReference type="OrthoDB" id="3921198at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF23">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="283"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW59039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="685" mass="76721" checksum="657D476D8C5CA5B5" modified="2019-01-16" version="1">MTTASLDEDHPSRRASLLREAENERLRIMEQILQHFIGNVPSDIDSLRRVAETLNGEHSRQPNSVRNEGADDSDDSAIGEESFTVNEISENAARPFPTPCALIILESSRIGTFRNAFSDRHEISDEKEYYRAKHLQSSGPTLSAVTQWFPPQPVAEFLISIFFKYGQTNYFYVEEKWATAQLQSIYKQKSSGSSDDSPAWCIVLMLLAIGTQFVDLDSVEDSEQSVGSPSHDGSAAEDDVGVTLYMQAVKLIPDILTIASMESVQAFLLLGVYTLPLDTSGLSYTYLGMAIKMAIQNGMHRRYSGVSLDEHGLEVRKRLWWTVYTLEKRICILHGRPLSISSSDIDAELPTDMPNFQPPNFANLRAIIMLNRHLESIASTIIQLRNSPKSLQIDRLDELMRHSESLKSLWSSLPSDIYCNDLDPQKSMFRANVHLNLAFLLTQVFMGRPFLFTYSKVSGSSEPTRSRASIARATLASDCIQAAHQILDLCQLLNDHGGLARASYIELSACRTALLVFLAHSLNENTKRLRKSLTNGMSLMRLMTRGIDSAKSEFSIIELLERAITRLNARPVSEAGNINQQPSGYEKYKHWAQLWKQQSPQAQNGLIQMNPQPTETPSTDEVTELLWSSAETNMSNFALDPFFAYSQPIGESEVGQPGNYLYQSDTGTLPNLSLESGWMGYQMPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QBE2</accession>
    <name>A0A3D8QBE2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_12013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QBE2"/>
    <dbReference type="OrthoDB" id="10641870at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017621458" evidence="2">
        <location>
            <begin position="22"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW59089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="202" mass="18811" checksum="9975D13A4F00CB49" modified="2019-01-16" version="1">MRSNAFFSFALVAIFTSPAVAGPIDSKLLSIFGSKVDVAAPPAPTAPGNVTATPPAPPAPLNGTASPPSPPCALNGTTPPGAANAAAAPPALGNDTATPPIPPAPLNGTAPPPPPAALNGTAPPAPANAAAAPQTPLTPGNGTATPPPPPGALDGTALPGPANSAAAPPAPPTPGNGTATPPPPPAPLNRTAPAAPPALPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QBN4</accession>
    <name>A0A3D8QBN4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12113</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QBN4"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW59189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="164" mass="18384" checksum="B2620550FC83A180" modified="2019-01-16" version="1">MGNHVRQNPTRRICRDPGTPGSISAPQEMIMHGNIEGSGNARQQLGSRIMGLPRDFGIEVIPVGVKVPASNADDGVFVVAIDDLHVPDGRIANEASSLFVEVEGQSGFRFFFRLYWAADGDREPGQVLAWRVSGRMRRQFIKVLELYRAKLKMHSEGEREFFEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QBT3</accession>
    <name>A0A3D8QBT3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Sialidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12034</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QBT3"/>
    <dbReference type="OrthoDB" id="2739686at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011040">
        <property type="entry name" value="Sialidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38792">
        <property type="entry name" value="BNR/ASP-BOX REPEAT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G06430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38792:SF3">
        <property type="entry name" value="BNR_ASP-BOX REPEAT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G06430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13088">
        <property type="entry name" value="BNR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sialidase" evidence="1">
        <location>
            <begin position="45"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW59110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="345" mass="37631" checksum="33867022814E072F" modified="2019-01-16" version="1">MLSLSGDAVALNVGEGASVYPRANYLANGHILGAYTAFPPATGVQQLTLVTSTDQGASWHLTGTAATRPVNEASLDNPYPLQLPSGEILLAYRNHDKDEQNNWTTYRITISRSRDLGLTWEFLSEPVVIDARCSTNGAWEPFLRNTKDGTLELYYSQELKDDDQDNVMLVSADGGLTWHHEKPISGAHRKSSRDGMVGVVEVSEGSLLAVYESNDRGGCFSVYSSSSSNHGETWDDRRPVYIAPPGRNAGAPQVIRVGDTLVVSFMTDEDRAANEDPETRRRNWPEIAAAKLLTSSDGGVTWDNKLTVFPIHADWPGLLALRDEEAFLYLAGYGGGVKAQKVVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QC07</accession>
    <name>A0A3D8QC07_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_12062</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QC07"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="17"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW59138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="350" mass="37489" checksum="C5E58FB6CB0F1EAF" modified="2019-01-16" version="1">MSDKQELNYAAVLPEKGAHLKTLVRAIPVPGPDEILVRNHAIAANPVEWKMQTWSFFIQSYPTVLGSDVSGIITQIGSSVTKFKVGDRVTGFAGVIYNGNADHGAWQTYTLLKEIVTCKIPDFVSFEEGSVIPMAFATSAIALFVDLGIPYPAKTTQQPKPSGLLVWGAASAVGTAAVQLASNFGYKVYATASAKHHEYLKSLGAFKTFDYHDSDVVQQIVASAKSSSIQIDLGFDTVGAGDAPKLAAEVLLAARSTDKAKLALVLPWPGKEPQPEGIEIFQTNATRTSNDKSELGSWLFNDYLKVALENKTIVPSPKIEIVEGGLNAAQKVLDLLKAGVSGKKLVVKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QDP5</accession>
    <name>A0A3D8QDP5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GEgh 16 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_11578</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW59972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QDP5"/>
    <dbReference type="OrthoDB" id="3241054at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021476">
        <property type="entry name" value="Egh16-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618:SF3">
        <property type="entry name" value="GEGH 16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618">
        <property type="entry name" value="SURFACE PROTEIN MAS1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11327">
        <property type="entry name" value="Egh16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017813744" description="GEgh 16 protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW59972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="29598" checksum="B11A8FCACF173D25" modified="2019-01-16" version="1">MPSLVQILLVVPAVFAVAHGQGLIVQAQGTAGSPASLGLQVKLGQSDANIINTAEITSNVVNECGRTLLAGNIDVGENTETQLAAKTVTSVTKGSTVDVTIQQVSADGAGPYTCDMDLTSNADGATGQTNLTVTEKDTTGGNITLSVTMPTDMACVGASTGNVCTIRCFNSAAAGPFGGCFAVQQTDVKANANSPNTITTAQTLAGVEAQVLQNQKDLPAEVKANSEASLAQQGLLAVNALLSSSAGVVAQATSTSSSKASKATKAAGAKAAGAKAAAAKAAAAKANASKGQKGARAFTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QDU7</accession>
    <name>A0A3D8QDU7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">5-aminolevulinate synthase</fullName>
            <ecNumber evidence="11">2.3.1.37</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">5-aminolevulinic acid synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Delta-ALA synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Delta-aminolevulinate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_11628</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>succinyl-CoA + glycine + H(+) = 5-aminolevulinate + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:12921"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="2.3.1.37"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from glycine: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.37" evidence="11"/>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QDU7"/>
    <dbReference type="OrthoDB" id="10263824at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00375"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003870">
        <property type="term" value="F:5-aminolevulinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06454">
        <property type="entry name" value="KBL_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000006">
        <property type="entry name" value="5-aminolevulinate synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010961">
        <property type="entry name" value="4pyrrol_synth_NH2levulA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001917">
        <property type="entry name" value="Aminotrans_II_pyridoxalP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050087">
        <property type="entry name" value="AON_synthase_class-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01821">
        <property type="entry name" value="5aminolev_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693:SF102">
        <property type="entry name" value="2-AMINO-3-KETOBUTYRATE COENZYME A LIGASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13693">
        <property type="entry name" value="CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00599">
        <property type="entry name" value="AA_TRANSFER_CLASS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 11" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="12">
        <location>
            <begin position="176"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU910713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW60022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="610" mass="65281" checksum="34992FC1539622BA" modified="2019-01-16" version="1">MATMDAALRQSKALCPFMKKASPATLRSLSTASRQTSPCGGSMSNLQTIARRCPIMGKAMAVQTAKAGKVGLGGMAAIGALRAFSGKVSSGKAKLHTSRSNAATAVDAPLFGHDKAFQPGKPARAARRDGKFDYEGFYSAELDKKHKDKSYRYFNNINRLAKEFPRAHMSDKNERVTVWCSNDYLGMGSNPHVLKTMHETLDVYGAGAGGTRNISGHNQHAVELEARIAKLHAKEAALVFTSCYVANDATLTTLGSKLPNCVYLSDSLNHNSMITGIKHSGAKKIVFKHNDLVDLEAKLASLPLEVPKIIAFESVYSMCGSIGPIEGICDLAEKYGALTFLDEVHAVGMYGPHGAGVAEHLDYEAHIAGRPRGTVMDRVDIITATLGKAYGCVGGYIAGSAKMVDAVRSLAAGFIFTTTLPPATMAGARTAIEYQMEYQGDRRLQQLHTRAVKDSLSARDIPVIPNPSHIVPVLVGNAELAKKASDMLLEDYGIYVQSINYPTVPVGQERLRITPTPGHTREYRDQLVEAVDEVFTKLSIKRTSEWAAEGGFIGVGDPAAAVEPIWTDAQLGIDEVVKEMKAGAGPVGIMEALLERETKATANAVGAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QER3</accession>
    <name>A0A3D8QER3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DRMBL-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_11744</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QER3"/>
    <dbReference type="OrthoDB" id="262529at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16273">
        <property type="entry name" value="SNM1A-1C-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000038">
        <property type="entry name" value="DNA cross-link repair protein pso2/snm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011084">
        <property type="entry name" value="DRMBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240:SF6">
        <property type="entry name" value="DNA CROSS-LINK REPAIR 1A PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23240">
        <property type="entry name" value="DNA CROSS-LINK REPAIR PROTEIN PSO2/SNM1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07522">
        <property type="entry name" value="DRMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA repair metallo-beta-lactamase" evidence="7">
        <location>
            <begin position="783"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="157"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="49"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="192"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW60138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="907" mass="99726" checksum="D1E9EA79480E0521" modified="2019-01-16" version="1">MFRNPRENASPTIETPLRPSTGRPPTPPGSIPAYHSAARREAEAAAAATMTTRSSTNPLTPRASTKTNITAMSRQGSKKTVHGKTPSKPNSSILSFFKKVDSPLKDDSIFLTERANGNNDAPMAREYGSEVFDGEVEELIGNTITTNIERFNEAGGSVKRRKLSNTHTAEKPISENDLPELDGSDDVHHPDNSPTSCTQQPPEAATTKPTKRRRTGPFLDDSDSEDDVDDETAQHYPSAAEEVLEAPVSQKPSSMNNVMSTNPVKQEAIQENNPVIPASKSLQSVSRRTSVASIGASSVADSPGSLRDQDQSFLPRLKKEDTSIDDFAGFEDLEEFPDDEYADGEEFIERKWMEEQAMLEAAENMDEGLMAVDEPAATDDDSGQITAACPICNSRLCDITADQATRHVNACLDGNPIPLPIPIKRERSEAKLMPIGAKHRFSKAAIARPGQENPFQLESVAATPSSAFSKLMSSKAEDAAWISAAAAENASRGKPAYQRTCPFYKIMPGFFICVDAFRYGAVQGCNAYFLSHFHSDHYIGLTSSWCHGPIYCSKVTANLVKQQLRVDSKWVVALDFEERVEVPGTQGVAVTMIPANHCPGSSLYLFEKVVGKGSNPKVQRVLHCGDFRACPAHIAHPMLMPDVLDSISGKTKQQKIDVCYLDTTYLNPRYAFPSQDEVIKACADMCVSLKKERAEESDAWEKVKKERAGQGMTKFVNSAVKSADDSIAMEINSTKPRGRLLVICGTYSIGKERICMGIARALDCKIWAPPGKMKICAALEDPELMSRMTNDPKEAQIHMQMLMEIRAETLQDYLNSYKPHFSRIVGFRPSGWNYRPPNSRSESLPVYSRNALTQVTDLQTLHPSQPFYIRPVGNRDTLWLNLYLSVAALGKHPALAYRTVSTAVSVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QF38</accession>
    <name>A0A3D8QF38_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_11866</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QF38"/>
    <dbReference type="OrthoDB" id="1601230at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044662">
        <property type="entry name" value="HS1/DABB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33178:SF10">
        <property type="entry name" value="STRESS-RESPONSE A_B BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="2">
        <location>
            <begin position="45"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW60260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="152" mass="16862" checksum="F1B2901E281E3FDA" modified="2019-01-16" version="1">MLSKPKLFILAGLAFIALFGFINFPSGSSSPSEPRPSFTKAKMRIIHIVMFEFKEEVTAEEIAVICDKMLALKDKCLHPTTNTPYVKMAMGGKENSPEGIAGGITHAFVEEFENEEDRKYYLEKDPAHLAFVESVGPMVKKAQVVDFTPGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QHL1</accession>
    <name>A0A3D8QHL1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative phosducin-like protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_11225</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QHL1"/>
    <dbReference type="OrthoDB" id="45518at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02988">
        <property type="entry name" value="Phd_like_VIAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051498">
        <property type="entry name" value="Phosducin-like_chap/apop_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809:SF3">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="3">
        <location>
            <begin position="71"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="220"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW61333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="257" mass="29296" checksum="9335EDE2CAC64BEA" modified="2019-01-16" version="1">MAAPMEERIAVPIDDPNADTEWNDILRSKGIIPEKPPSPTPMIEEAILEGRRLAHENRLEGKDIDELDELEDEEDEAFLEAYRQQRVQELASLTKKSLHGTVYPISKPDFVREVTEASKNGAVLVNLTSNLGTNVESRILTELWRTAAREYGEIKFCEIRGDMAIEGYPDRNCPTILVYNNGDIVKQVVTLMTMSGVRVGMKEIDDLLLEIGAIRDNDMRVQKRRRDKEDEEEERRERGGIRGKGNQANVEDDDDWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLA3</accession>
    <name>A0A3D8QLA3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter-49</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_10793</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLA3"/>
    <dbReference type="OrthoDB" id="4161376at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF195">
        <property type="entry name" value="PEP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="393"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="544"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="59"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW62491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="587" mass="63758" checksum="BB36AF2BD7FB3129" modified="2019-01-16" version="1">MSQPTTPDWKPASNSENRDMTAGDKPEKDTTIKNALANRRESGDGQDDEAAPHLHMKTFLAVFSVCLIYFAQDFALVGAGSQGQIISSHFGRPGDTVWITAPITIFTVVLGPIVSQAADYWGRKWFLVVLSLFGSVGCVIIARATNMGMIIAGSCIIGIGFGAQPLLHTVASEVLPRRWRAWAQSAVMASNGLGLLVGLLAGGAFNRHGNPDGFRYHFYFAMAFFALASVICIFVYQPPQTDLQSTLSFKEKVSQLDWIGYILLASSLVLFCMGLFWSQNPYAWSNAHPSAPFAVGLALASVLIFYEAKLKKDGMFHHGLFMANWNFTISMICVFCEGMAFFAATIYFPFQVSVLYETDFLMVSVRFSVAYITTLAASLFTGVYCNMTKKVRWVTFAAFVVFVAFFVCMATTNKNSSLPVWGYPVLMGWALGMTLVTLITAAQLSIRAELISVASGLIISVRSLGATIGIAIYNSVFISATRRLEGNISKAVAAAGLPQASIENFVAGLLAQNTTGLSQVFGVNQDIIQAGFGALQDTYSAGFRNVWCTAAAFTVLALVASVFLFDPSNEFNNHIDAPIEKEEDLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLP7</accession>
    <name>A0A3D8QLP7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha hydrolase-14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_10882</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLP7"/>
    <dbReference type="OrthoDB" id="5409895at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010520">
        <property type="entry name" value="FrsA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050261">
        <property type="entry name" value="FrsA_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946:SF12">
        <property type="entry name" value="CONIDIAL PIGMENT BIOSYNTHESIS PROTEIN AYG1 (AFU_ORTHOLOGUE AFUA_2G17550)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22946">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06500">
        <property type="entry name" value="FrsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW62580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="433" mass="48704" checksum="666034AC6535AB7F" modified="2019-01-16" version="1">MAEQASAKGSQRSWILGEKFDKRMPHHDGIKALWETKWKFPCTISVYPFHDGKFQDFEPVFEYLIAVSLDIEARVSRKQSVSALTSGKNDINDGFGDAYTEAFFPIAERLTAEGDECEDSAKASELYLRAACLYRIARFPYITNFPEVNSQSKWRAWQAQKEVYLKAGSKWDCPVRAVDVPHTERQGADRETIPVYVRLPKTAESGSNCPVVLLFTGLDGYRPDNTQRCEEFLSRGWGCVIVEVPGTAECPADPSDAAGPDRLWTALLDWMQKENSFDMQKVMVWGLSTGGYYAVRIAHTHRERLVGVIAQGAGTHYFFDADWIEKADGHEYPFALGPPITQKHGYASFEEFKEGAQKKFSLLETGILEKPATRLLLINGVDDGLMPIEDSMLLFEHGTPKEARFFAKALHMGYPMANAAVYPWMESVIASHI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QM57</accession>
    <name>A0A3D8QM57_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HPt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_11080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QM57"/>
    <dbReference type="OrthoDB" id="1673781at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043424">
        <property type="term" value="F:protein histidine kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00088">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.160:FF:000007">
        <property type="entry name" value="Multistep phosphorelay regulator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.160">
        <property type="entry name" value="HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045871">
        <property type="entry name" value="AHP1-5/YPD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036641">
        <property type="entry name" value="HPT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008207">
        <property type="entry name" value="Sig_transdc_His_kin_Hpt_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28242">
        <property type="entry name" value="PHOSPHORELAY INTERMEDIATE PROTEIN YPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28242:SF52">
        <property type="entry name" value="PHOSPHORELAY INTERMEDIATE PROTEIN YPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01627">
        <property type="entry name" value="Hpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00073">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47226">
        <property type="entry name" value="Histidine-containing phosphotransfer domain, HPT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50894">
        <property type="entry name" value="HPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HPt" evidence="3">
        <location>
            <begin position="45"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphohistidine" evidence="1">
        <location>
            <position position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW62778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="156" mass="17372" checksum="07A7864F6BB159B0" modified="2019-01-16" version="1">MSPTTHDEERSEEGSVGAPDLSALGPNIDVLTFEQILEMDDDEDEREFSRSIVFGFFEQAEATFVKMEDALKDKDLATLSSLGHFLKGSSATLGLTKVKDSCEKIQHYGAKKDEDGTADEPDEEKCLERIKETLDTVKEEYAEVEKSLKKFFGPAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQP0</accession>
    <name>A0A3D8QQP0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_10490</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW63988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQP0"/>
    <dbReference type="OrthoDB" id="5667at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF224">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="91"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="294"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW63988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="482" mass="51872" checksum="7C7AEBB9274F928C" modified="2019-01-16" version="1">MAVDSSGSSTIGGDSVRDAQEKTPEAGDSTVNQRLSESSPRSPIKETEANIFPETQDTAEADLEKGGIVPPKPAAPGGFNPADFPDGGLEAWLVVAGAFCCLFVSFGWINCIGIFETYYLETLLSQYSSSTVAWIPSCEVCMMFIGGPIFGFIFDSYGPRYLLLGGTFFHVFGLMMTSLSTQYYQLILAQGICSAIGASAVFYPAMSCVSTWFFKNRAAAFGVMASGSSLGGVIFPIMIQRLIPRVGFPWAMRIAAFLVLGLLIIANLTVKSRLPHTPKKLQFMAFIKPFSEPAFTLMCTGSFLFVFGLFLPFNFITLQAQSIGMSSHLSGYLIPILNAASIFGRIFPGIAGDRWGRYNVLMFTSVFSFIIILALWLPSKSNAPAIVFAALYGFSSGAWISTSPAIIAQISPIREIGVRNGSMFALIAISALFGSPIGGALITKDHGGYLYMQIFAGAIMAVGCVFYMGSRYTQAGFALKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQS8</accession>
    <name>A0A3D8QQS8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_10647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MDM20/NAA25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQS8"/>
    <dbReference type="OrthoDB" id="1874341at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019183">
        <property type="entry name" value="NAA25_NatB_aux_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF3">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 25, NATB AUXILIARY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09797">
        <property type="entry name" value="NatB_MDM20"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW64145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1063" mass="119688" checksum="A477F311B3E6B47C" modified="2019-01-16" version="1">MVDQLVPRPGDAAIWTSVDSKNFKQALKTVEKRLAKKPNDDYLQALKLYIRTEAAHAAGKEFHEYKEFFVELESIVAKDAVHDEEAIVLYDTVLALILPGQLSLWRDIIGTMRWNAVKASPKDAQLAITHFQSCLSNQDLAHAQVICNSLEKNFPQEHRYVLWNITLHYLKSLITSLDQKDRDMSSRMATAMIRKLAEATKTAKDVSSLPPRAIHSPQESLLLHRILESGSDIDIRLKYYEDDYTGPGSKVAKGTWKLWTDKLKLLEKAEKYDDLLEISSSLLPLGRKNASGVVVDSRMGDYTIWELFRKTANLTMEPESAYSIIMAEVDAYLKKDSGVEKVYRRNAALTEVVATFEYLKLCPQPYFSIGSKGSEEPLDPAEVHVQTTDVLLKYLSKNAHIISVFSDLRPYIGRLDVDERREFLLRISKLGKFGIEVLPFEVDDSSSESKQALAEHHLNTQEDITSCVNRYKIAYLITSSLSEIDRLASVPAENTDNKHGVPYFAPGINCKEDRFICPWCSKPCAVYCTSCLEKHARLSVLAYGSAINDNGRITSTLLPTDIHPADDFCILAAMCLVKLAGFYPWPLEEATCVPLTGDRLSHLLRASLILEYAWSHSKANSQISLLLVRLYAHLGCGSLAMRAYDRLGIKQIQTTTLAYTLFDRISSLHPHPFVHLQDGGHRTKSPMEQLANHQTTYESFAGQVSRNIFRAFEHGSYDSAVQLVGTSQFLTESDASILAFLESRRMSRITEPELLLKPEAHGFNLLPYNCGSMPFKTDYRTSFDYKSFPNFEATNCPSFVGYTALGPDVSVKRLTKSLLAERVHFHIDPRTDENGKQWSHMWFRGSFVQMHKYLSNLAHDNPSGPINTTFEQLALEVYILMGQVIFAAEEHDKADTNHLRNLTKTVQISCSKLMKLLKKISTKASVPGFMSTLHPLYMAHELAIAILNFDRYFRLSGKCKCTFVAQLQASNKESVLIAERLLKEVLSISENSRKSMDESGWIDRVLDSVIDGDKDDSGEKSTTLAGAFKATVDADFMENWAGEVVESWRDSVMGLACLKGFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQT1</accession>
    <name>A0A3D8QQT1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="10">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_10573</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the tannase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQT1"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF15">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017494187" description="Carboxylic ester hydrolase" evidence="10">
        <location>
            <begin position="23"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW64071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="536" mass="58434" checksum="5AAD58401B747F11" modified="2019-01-16" version="1">MFSLLRPFGLQTLLATSSLTVAQNLTVADPAAACNALGQSLALENVTVNFAEYLPAGTNLSFSQDYNLSTCGSVSQVVPVDLCRVAMYVATTNRSGISLEGWLPTNWTGRFLMTGNGGLSGCISYEDVAYATSFGFATFGQNNGHNGTRGYAFYQNSDVVEDFVYRGLYTGTVIGKQITNTYYTQSLSTSFYLGCSTGGRQGWKMIQDYPDVFDGVVVGAPALFFPGLTSWSGIFYTILGNSSSDTFVSADLWAAVNNEIMNQCDGIDGAMDGIIEDTLLCNFRPEAMQCAPGVTNSTTCLTSAQVGAVRQVFTDYYGLDGLLVYPKMQPGSELLARYIYYGGTAFQYTADWFRYVVYEDPSWDPASFTRADTKAAIDQNPFNALTWNGDISAFQKHGGKVLHWHGEADYIITSDNSPRYYNHVSQTMGLPSSELDDFYRFFRVSGTGHCQGGAGAHMIGQQATESAATDPQNNILARIITWVEDGNAPETITGTKYVNDDATQGVAFVRNHCKYPLRNVYTGPANYTQPEAWTCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QRF1</accession>
    <name>A0A3D8QRF1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_10750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QRF1"/>
    <dbReference type="OrthoDB" id="3183782at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="2">
        <location>
            <begin position="14"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW64248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="126" mass="14295" checksum="A8D0E863DAFC19AD" modified="2019-01-16" version="1">MAVHLTILIKKLDSLTDEQFHTYWSNEHPKIWGSVPIVQAKIVKYSQFHVDAQTTAGLRAAGLPLAEFDGGVEMWADSVEELMAVFQDEEYLRVVVPDEESFLKRSEAVMMLGNDEVKWDIGKKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QTT7</accession>
    <name>A0A3D8QTT7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 19">Alpha-amylase</fullName>
            <ecNumber evidence="4 19">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BP5796_09879</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4 19"/>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QTT7"/>
    <dbReference type="OrthoDB" id="204980at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11319">
        <property type="entry name" value="AmyAc_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000120">
        <property type="entry name" value="Alpha-amylase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013777">
        <property type="entry name" value="A-amylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015340">
        <property type="entry name" value="A_amylase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006046">
        <property type="entry name" value="Alpha_amylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF215">
        <property type="entry name" value="ALPHA-AMYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09260">
        <property type="entry name" value="A_amylase_dom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001024">
        <property type="entry name" value="Alph-amyl_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00110">
        <property type="entry name" value="ALPHAAMYLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="11 19" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 19" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 19" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="20">
        <location>
            <begin position="14"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="205"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="229"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="123"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="14">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="32"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU003615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU361134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RDW65187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="578" mass="63938" checksum="B026A9616D88922B" modified="2019-01-16" version="1">MANYMAWKERSIYQVLTDRFAVAGHGNSGPQCDPFAGKHCGGTWRGIIEKLDYIQGMGFDAVWISPITKNLDDTTLYGEAYHGYWQDDLYSVNCHFGTTEDLLALSDALHDRGMFLMVDVIVNHMGSLPDLDFSRLVPFNDASYFHPQKYITNYGDQCLVEQGWLGDSKVPLPDLDTENPTVVRTLYAWINALVQKFGIDGLRIDAAKHIRKDFWPGFIKSAGVWSVGEVLSGDPGYLGSYQPYVGGLLDYGTLFSLKRAFKAGIGNMYELSNLLNSDYRAHFPDVQQMATFMENHDMARFTSDTNADLTVIMNALAWTFLADGIPVLYYGQEQSYTGENDGDPESRDVLWRSGYKTTLLYKFISLLNRVRKVSWKAGYGTNLATCLYAELDVLATQKGPLIMVLSNQGSHEKDRTISFSTKFSDTTETTLVDLLTNEQIVVKNSLTVTLVAGQPRLYLPLQLASQVCSSTKSPQVSSASLLVQNLSGMKMSSANVDLDVSQPAITWSLGAPANTHDILNEPLPLEDGLILTPAIDATETPYSMFTGISSLQASSEEIDSCRSQAPTSHLLSPSIKVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QU46</accession>
    <name>A0A3D8QU46_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_09900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tannase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QU46"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF16">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017495316" description="Carboxylic ester hydrolase" evidence="8">
        <location>
            <begin position="21"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW65208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="583" mass="64004" checksum="1D52B657B83E44DD" modified="2019-01-16" version="1">MRALTQALLVAAMASAQVQAVTLDDVCTVAYVEASLPDSITYLGTTAVTIDPSSIQVNPVLNNTVTDSSMFPDGQFDYCNVTFAYTHTGRNDSVTVAYWLPTPASFKNRYLATGGGGYAINSGTGNSGSLPGGVFYGAVAGATDGGFGNFDTNFDAVYIIQNGTTDLESLFMFGYQAVHELTLLGQLFTKSFFNMSDNKLYSYYQGCSEGGRDGWSQVQRFTDFDGVVTGAPAFRFSFQQVQHLYSNVVEQTLGYYPTACELQKIVNETIAACDPLDGLTDGVVARTDLCKLHFNTSSIIGKAYYCPATPVYAGFPPAPAWPEQNGTVTAEAIATTDKIIDGLRDTDGKRVYFSYQPSSIFADGYTSYNTSSDTWGLYLNQFGTEFVARYLELLDTNLISLDGVTYDTLKQWIIEGWKKYDDTLHTTWPDLTAYHDAGGKILHYHGESDFSIPTASSVRYHESVRQVMYGNLTFNESTEALSDWYRLYLVPGAQHCAPNAYQPNGPFPQTNLGVLIDWVENGLTPDTLNATHLAGSKIGQNAQICAWPLRPLWAVNGTMECVYDQASIDTWLYDFDAFNLPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUE6</accession>
    <name>A0A3D8QUE6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_10000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUE6"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW65308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="64" mass="7076" checksum="CE70CE5A41B623EB" modified="2019-01-16" version="1">MTDPYPDEQLVAKSLPSSPQEPPLNETQTEFTTQACLAILGAFFAIFCSVGYTNAFGVFQEYYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QV11</accession>
    <name>A0A3D8QV11_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_10192</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QV11"/>
    <dbReference type="OrthoDB" id="4215304at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050226">
        <property type="entry name" value="NagZ_Beta-hexosaminidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480">
        <property type="entry name" value="BETA-HEXOSAMINIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30480:SF16">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 3 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="560"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="5">
        <location>
            <begin position="726"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW65500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="871" mass="94494" checksum="52A11CC8565E78C0" modified="2019-01-16" version="1">MSASGSQSVTWSEEELKSKVGQLFIVGFHDHVPNEDIRTLITTYKIGSIVLFQRNVASAVQLLELTNSLQEIARSSGHDQNLFIGIDQENGLVTRIKAPIAAQLPGSMALGATGDPNNAFEVASATAATLASFGINMNYAPIADVNSEPKNPVIGVRSPSDDPETVGRFVSAQIAGLRQGGIVPCVKHFPGHGDTAVDSHYGLPVITKSRQSLDSCELVPFRRAAAQGVESIMTAHIALPGLSDPKPGEKLDEVPASLNPKAIDILRKEMKYEGLIISDCLEMDGVRATYGTEKGAAMALKAGTDCVMICHTIAAQIGAIELVIEAVKSGELSQEAIEASVQRVRKLKEKYLAPDTIIPTSSLAEMDSRIAEQTKLASIMYEKSTTLVRSEPGSLPLKATPEAKLVFLSPGKAPLPGGAVDSGIEKTREPYTPSTYIDILRAEVPSAKDIRFLDSVPLSATEEKDIADADAVIFATRNASLSAYQKDLGLALGKKLGSKMIVVATCDPYDFLQEVSEIKNYITIYEPTVPAFKAAVNFIFGKAKALGSLPVGTAINMHEVRIFDGSEDDITFVYDLYNKLFPQWAINRDLLTKLLNHPSGQHFVHEHGFCIAYLTNSGHGKITCVGVAEGHRNQGIGTALITRSQEQLRGVAYMVGLGDLKSLGVGSVFPRFWPGIPIEFPQEVKEFFAHRGFQKHKSPTARDMYRDIRQEVAPAAVLDRVSKLDLTFAPLSPDKYEECITKQRANFKQIGWVQAYERLAAAGQHHEVMVAFLPDGSQVGWTLMCSASSVVGQDFAYLPLLPSGDKTGLIACVGVDASGRGKGVGLALLVKAMEDMRRRGMEGVCIDWVVIRGFYETLGFKPYWEYEGFDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QXT6</accession>
    <name>A0A3D8QXT6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transferase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09361</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QXT6"/>
    <dbReference type="OrthoDB" id="1862401at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050317">
        <property type="entry name" value="Plant_Fungal_Acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642:SF310">
        <property type="entry name" value="FATTY ALCOHOL:CAFFEOYL-COA ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31642">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW66612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="392" mass="43258" checksum="B0299B7737CD3C51" modified="2019-01-16" version="1">MASSTIPDIYALTPLEKIGPKAYLQYIVSILKAGYYAASKRFAPLACEAVPNAEAKQAGIWKLKPIDDQEFEAITLRDLRAAGERFRVCQIQANFIPGGLILGWSILHMFGDGTTFAVWTQIWAEEYQRAQNLDIPNPIQLPETIFKDRELLMKPSGRNAGHLKDHSEYTLLSFTPTGAPLKMASKNHRGQVFYFSPEMLQALKKEAWPDKARASTTQKWISTNDALSALLWRTVMAVHFPLETLEGDSVSTFNIAIDGQSRTNPPVHPQTLGCFLEYVALSLPIREILSSMSLADEWTDDITTLIDKHVVDVDRVVPTAFLDVPGFNCVQSSGANFALYDLDWGHALGNKIQAVRSPSNGVINGLQVILPTLPDGGLEVLVGVEELPQPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QXU4</accession>
    <name>A0A3D8QXU4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alcohol dehydrogenase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_09402</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QXU4"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="6">
        <location>
            <begin position="18"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="5">
        <location>
            <position position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW66653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="323" mass="35703" checksum="7CC77F2629916595" modified="2019-01-16" version="1">MSLGRTLTLNTGAKVPAVGFGTWQAAPKEVEKAVEVALQSGYRHIDCAAIYRNENEVGAGIKKSGVKREDIFITGKLWNTCHRPEDVEKALDKSLADLGTDYVDLYLMHWPCAFKPGPKFFPLDSDGVFQLDDVDPAVTWKAMEALVKTGKAKAVGVSNFNVRRLEALLANCSVVPAVNQIEAHPYLQQPELFDFCKSKGIQVAAYSPLGNNQTGEPRTVDDPKVHEVAEKLGRDPGQVLASWGVQRGTIVLPKSVTPSRIASNFQDFIIPDEQYKELNALERHKRFNFPARWGFDIFDEAGEDVVKKAAKDAGEENKTKFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYI6</accession>
    <name>A0A3D8QYI6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">S-adenosyl-L-methionine-dependent methyltransferase-14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_09363</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYI6"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF31">
        <property type="entry name" value="LAEA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW66614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="342" mass="38549" checksum="7186C03E7FC9F300" modified="2019-01-16" version="1">MATSSQAADAIIAPEDDDWADDDSAIGNSTLAGSTSSLASSILKYRHENGRTYHSYKEGKYMLPNDESEMDRLDLLHHLCGLTFDNKLFLCPIDTKKVHRVLDSGTGTGIWAIDFGDENPQAQVIGVDLSPIQPQFVPPNVAFQVDDIEEPWTFSYKFDFIYSRRMHGSIKSWPRFFGQAFANLNPGGWIECCDGILPMRTDDNSFPENSALKRWGDLMVDVMSESKFGRPLDSALHYESQLAAAGFKNIVVLDYKWPTNRWPKDKKLKEFGMWNNSNLVEGIAGLSTAACTRLCGMSLQETETFMEDCRKELNDTRIHAYWPLRVVYGQKPEAPSSMDTKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYJ3</accession>
    <name>A0A3D8QYJ3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Beta-xylanase</fullName>
            <ecNumber evidence="12">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BP5796_09584</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the glycosyl hydrolase 10 (cellulase F) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="12"/>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYJ3"/>
    <dbReference type="OrthoDB" id="3055998at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044846">
        <property type="entry name" value="GH10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031158">
        <property type="entry name" value="GH10_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001000">
        <property type="entry name" value="GH10_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490:SF35">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31490">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00331">
        <property type="entry name" value="Glyco_hydro_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00134">
        <property type="entry name" value="GLHYDRLASE10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00633">
        <property type="entry name" value="Glyco_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00591">
        <property type="entry name" value="GH10_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51760">
        <property type="entry name" value="GH10_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 12 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 12 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="6 15" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017623479" description="Beta-xylanase" evidence="13">
        <location>
            <begin position="23"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="GH10" evidence="14">
        <location>
            <begin position="18"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDW66835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="354" mass="39174" checksum="06CF01CEAB6562A6" modified="2019-01-16" version="1">MHLPTKITALSLSLLLASTANAKLNQLAKHAGKLYFGTATDNGELNNTQYVSILSDRREFGQLTPANGMKWEYVEPEQGVFNYTDGSVVANLATKNHQLLRCHNLVWHSQLPDWVPNTNWTKATLKAALIDHVTQEARHWAGQCYAWDVLNEALNEDGTFRNDTFYEVLGEEYIKIAFKAAAEADPKAKLYYNDYNIESPGPKSTAALGIVTMLQEAGLRIDGVGLQSHFIVGSTPTIDQQISNMKSFTDLGVDVAITELDIRLLLPSNATNLQQQSKDYETSVGACVQVEGCVGITVWDFWDPVSWVPGVFAGYGDADLWFANFTKHPAYYGVEAALKNATRKGSKDWAEDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYR0</accession>
    <name>A0A3D8QYR0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Aspartokinase</fullName>
            <ecNumber evidence="7">2.7.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_09443</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-aspartate + ATP = 4-phospho-L-aspartate + ADP</text>
            <dbReference type="Rhea" id="RHEA:23776"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57535"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the aspartokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.4" evidence="7"/>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYR0"/>
    <dbReference type="OrthoDB" id="4323675at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004072">
        <property type="term" value="F:aspartate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009090">
        <property type="term" value="P:homoserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009089">
        <property type="term" value="P:lysine biosynthetic process via diaminopimelate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2130.10:FF:000001">
        <property type="entry name" value="Bifunctional aspartokinase/homoserine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054352">
        <property type="entry name" value="ACT_Aspartokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001341">
        <property type="entry name" value="Asp_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018042">
        <property type="entry name" value="Aspartate_kinase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00657">
        <property type="entry name" value="asp_kinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499">
        <property type="entry name" value="ASPARTATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21499:SF59">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22468">
        <property type="entry name" value="ACT_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00324">
        <property type="entry name" value="ASPARTOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="ACT" evidence="9">
        <location>
            <begin position="436"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="294"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW66694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="518" mass="55948" checksum="14BA0197190EC583" modified="2019-01-16" version="1">MPAILPSPPVRKPWIVQKYGGTSLGNLLETITITIIPQYLETHNVGVVCSAISGTSKALGTTALLLHAVKSALGGDQSQLDATIEKIRDEHIKAIKEIRIGVRCKVQASICDALQADIIRECNELNAFLNAAQGIPAKLVSLLDIVASVYGNDLNTQRQAYEGLGSKFYDGLVQEIGRKLRACEVEGTVPIITGFFGRLPESMLKSVGRGYSDFCAAMCALGVEAVELQIWKDVDGIFTADPRKIPSARLLSTITLEEAAELTYYGSEVIHPLTMEQIRKANIPLRLKNVKNPGGRGTIIYPSDDSSSGTSSDTPSPVSSTESLLQDTSIAGFMSANGYYGKGRHRRSPTALTAKDSMILLNIQSNRHVKSHGFLARVFGSLDELNVVADLVTTSEQSVSLAISSISRPEEEKRLFISLERFGKVEVRRDVSIVSVIGHKMRNMVGISGEILSKLAQAGINVYLIAQGASEINISCVVQSSDAPEAMQTIHTNVLGIPQHAEHAPIAQNSIMKGPWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYV3</accession>
    <name>A0A3D8QYV3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter-10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_09731</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYV3"/>
    <dbReference type="OrthoDB" id="5399138at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="18"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW66982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="508" mass="54215" checksum="0E5906D61A1678EB" modified="2019-01-16" version="1">MLPEPYRSWVHPPKYVEAAVLISLGGALFGFDTGTIGPITTMPQFAITFGNLSATVHGLVVSTILIPAAVSSFFGGHLANAVGRPRATAIGAGVFGLGAAIECASVKLAMLIVGRGVKGVGEGLFLSTLVVYITEISPPRSRGTLASIPQLLTTIGLCVGYFVCYGSTNINSSLAWRLPYAIQSGASFIFVITTLLFLPQSPRWLSASGRHSEALACWERLGVEAAEREKLEESTDEGLPEQVKMKDILAVFGRDVWKRTALGVFLMGMQQLSGIDGVLYYAPLLFQSAGLTSSTASFLASGVSALLIMLVTIPAFLYADKWGRKTSCVVGGLLMGIFMVIIGSLYASGSVHSTHGIARWVVVVMIYFFAIAFSATWAVGFRVYVSEIQPSKTRAGATSLSLSANWIVNWIVAFTTPIFLAKSSYGVYFLFGACLLLTVAVCIFIMPETTGRTLEDIDASFGKKLGKKRATGVVMELRDLEYTPCDTPANEKEDGVVVAAMSSSSSVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R2L1</accession>
    <name>A0A3D8R2L1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_08845</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R2L1"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="243"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW68188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="722" mass="77102" checksum="9D5E1D4300348862" modified="2019-01-16" version="1">MQHHWHSYIVDLLVKPVHNTGVNGAANLIVGIMKANEVLLLKADPHRPPNEHIIHPILAKDLPNLGFRYLDFRGVNVVHLAVSYGLSPSNKAVLGSYIYSYNGKQLKPFSSRHEHTRTQINAINMHRLLFVLVASSSLVLGSTTANNTCKTTPSEAGWPSAEEWSALNRTIGGTLIKTSPVASSCYAGNPFKSTVPCDTVEADWSYTTFHASLPESIDYPLYANNSCLPPGATGYTADKGCVVGALPQYVVNATLEEHISTGVAWATSHNIRIVVKGTGHDMNGRSSGAFALSIWTHNFNNISFNSAWPVPGSNVTADVIIAGSGNNWQRVYTAAEAVGKLIVGGGATTVGLGGFIQGGGHGPTSSHYGLAADQIYQVKIITTNGTLLVANPVQNQDLLWAIRGGGAGQYGVVTEYVLQAYPAPTSVALGTLTLSTNGTDNSSINAVWNALAVEVSSIPDLMDAGLAGVMEAISSVVSAGTKVTASHSFYGYNMTADNVTALLSPVIANMRVQGNNSTLSVSWTEPVTYPNFTAFFTALNPSAEGAGALSMMSSRLLGRDQLTNITQSQMVSYLKRALIAEKTGSGTYLIMGMQAGKGPANVPENMRGALQPSWRTAYVHTIALGAQFNLTVTPMTALGAAAEWVNNNKETVWQDWAPDMGAYMNEANPYNPNFKTDYYGSSYDRLLSIKKQYDPTGSLFVLTGVGSDKWDYNLDTGKLCQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R3J3</accession>
    <name>A0A3D8R3J3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Beta-ketoacyl synthase-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_09272</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000019">
        <property type="entry name" value="Polyketide synthase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="13"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="12">
        <location>
            <begin position="973"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2477"/>
            <end position="2554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="462"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="973"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1133"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="480"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="1003"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW68615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="2560" mass="279550" checksum="D674AEED6AD4C9E4" modified="2019-01-16" version="1">MTSSNNCSMDASSMPIAIIGIGLRFPGDGSDPEKFWQMLLDARSARSKIPKSRYNVDGFYHPDPNRLGVMNTKTAHFLKQDYKVFDAPFFSITPKEAKAMDPTHRMLLEVTYEGFENAGLSLDSVKGSKTSVYIGTFTNDFQGMQFRDNEGPSIYHATGLSGSLASNRLSWFYDLKGPSMTVDTACSSSLTAFHLACQSLRTGEAEMSVVGGSNLMFGPEMTILLGAAKILSPDGKSQMWDEKANGFSRGEGVGITVLKPLADAIRDGDTVRAVVLASASNQDGRTPGISLPSSEAQEELIRTAYRQAGVSPNETGYVEAHGTGTQAGDPLEASAILNTIGHDRKTQLYVGSVKTNIGHLEGAAGVAGVIKAALLVERGLVPENLWFNKLNPQITLPDNVKVPQELCTWPTSGPRRASVNSFGFGGANAHVVLEDAAHYLERFGLCGRHSTVITPRLPAVNGTKQLMNGNDTTGHESNGENHTNGLTQHTNGNPSSNTRPEKPKIFVLSSSDREGVKRGLQNLSDYVQQKDQDTDILDSLAYTLGERRTILPWKTYAVASNLDGLVKSLAEAPAATRSSDSHVPKTAFIFTGQGAQWFAMGRELFIYDVYRYSLDCCEETLRSLGCKWSLSEELNRAEADCNLHLAEFSQPACTAIQIALVDLFQHWGVVPSAVAGHSSGEIAAAYCAGAISRDTALRIAWFRGQYAGVLAKKNLNGAMLAVSAGADDIRPKLAEISSGNAVVGCLNSPKACTVSGDKSAIDDLCTLLTKDQISHTKLNVDVAYHSPHMENIRDEYEAAISGFEVGSSIEMVPMFSSVTGSIVRPEELGPRYWVNNLTSPVNFTGAIKALLHHSEGQKRATDRAAFASIFLEVGPHSALRSYLLDVFKTEEKFTDLSYVNVLRRGHDGVQTALAAVGQLYVKGCKSKLDLVNETSTTSKQLVDLPPYSWNHSVAFWQESYLSKQHRYREHPRLDLLGYPVPGAIEPQWRNFLRVSENPWIKEHCVQGNILYPGAGLMIMAIEGARQIADPNEEIIGYELRDVSISAALSIPNDDKGIETLVQFHPRRTGTKAGPSNTLNEFTVSSFSADNDQWQVHCRGLISVTTKSQITPAMEIELELESQKYATALNDAKAKCQKPVRSFLYDNVETIGMKYGPTFRNVTELYAGENSSYGIIKVPDTKAIMPESFEYPAVIHPALLDSVLHILFPSISGPDQSLTEAVVPYAIDRLFVSANVPSTPNTELHGYSKATKASYTTWTSSITFSDMESHAPLVIMEGLGLASVGANDSQSQDTRAQCFETMWHEDAELMSPQHIKKLVHKRTIPNADDDSVLDKLEYVCLVYMQRILDWFNSEGKECIPQSGFFKLYYEWIMEMMGSFPPLDSDLSKLNAEMAAARERISGSESGDITVQMVDRIGQNLTRIFAKEIEPLQVMLEGDLLYTFYRGAFGTSFNTNVAEYVGLIADKQPGLSILEIGAGTGGTTYHVLERLRNEDGTSKAQKYVFTDISPGFLAKAAERFSKDASIMDFSTLNVEDDPIDQGFEANSFDLIVCANVLHATKSIGETLTHCHSLLKPGGKLVLSEVTIKRIFCGFIMGPLPGWWLGEDDGRKGGPLLDVQEWDTALKKADFSGVDIDIRGDADNSKEPVSLLISTKPLEAQPETATKYAIIGTEGVLTSRLSEKIQDVLQSHNLQSSVLEWGHFSESDIADTYCICLAELEVPILAQISDENWAEFRRLLAGSRGTLWITSGAAMETSRPFGSLMVGLSRAIRNENANISLATLDIDFPSTADMEVTSTAVCKLAINHSRGNSVDHEYATRGGIIFVPRVTKAPGLNKQLLEYESQGDLEQVPFTSCGRPLKLTLKTPGLLDTFRFQEDEEYYKPMPEDWIEIQVKAVGLNFKDVLVAMGHLNEDKLGVDVSGVVTRVGTAVTGIAVGDRVMTSSCNTFATFVRFPALGSIAIPEGMSFEDAASMPLIYLTAYYALMTIGRLVQGETVLIHAAAGGVGQAAIVVAQHVGAEIFATVGSEEKKQLIMKEYGIPEDHIFSSRDLSFAKAIMRATNDVGVDVVLNSLAGEALRLSWHCLAKFGRFLEIGKADLFANTGLDMAPFLENKIYAGVNLIDFENNPTPRAVALFKEVGKLIKDGSISPVKPVMQFTFSDIEKAFRYMQTGKHSGKIVIRVDESDLVTAIPRTPQIEISANATYILAGGLGGICREIGRWLAEKGAENLVFLSRSAADGEENRAYIQGLKQMYGTNALAFNCDVADRESLASVLKKCESLPPIRGVVTGAMVLRDTLFDSMTIEHLRITVGPKVHGTWNLHDMLPKDLDFFVMLSSLAGVMGHRGQGNYGAGNIFQDQFASFRRTQGLRAMTIDIGYLLSVGFVAEHDEYVDHVKSMGLKVMNNNDLHGLMSIAMKGTEAHPPQVMIGLPTNEYDDSWYWIRDGKFASLLNRAQGHEATTGSSIALSEELIKATDLITAVDIICGAIVEKLAKLMMVPASDIDPAKPLSTYGVDSLVAVEVRNWMAKELLVEISVFEIMANVPMRQLAVDLAGKSKLVTSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R3Y0</accession>
    <name>A0A3D8R3Y0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_09327</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 'GDXG' lipolytic enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R3Y0"/>
    <dbReference type="OrthoDB" id="2336090at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033140">
        <property type="entry name" value="Lipase_GDXG_put_SER_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF19">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01174">
        <property type="entry name" value="LIPASE_GDXG_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="4">
        <location>
            <begin position="170"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW68670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="572" mass="63470" checksum="03A2081223887096" modified="2019-01-16" version="1">MGLNTLVAVEIVAPAMGRTALAMIKRKKKKGEDPTKEVSYRETLNLMRKMLLFTALNTVEDLQHATTGWLPHPLSVIVKDVTIPSNFYDDSARYIQANLGPANLSRVGKTWWQWRRPGSEVKAEWVEMKIDYLRRKRSNDPGKKVMFYIHGGAYYLGAIGHLGQVQRHARKHHSNIVIAGDSAGGGLCVALLLILRDQGIPLPAGASLISPWVDLTCSFPSITIPSDLDYLPAYGFHAKPSLSWPPPSSEELKALRWPIHPANDPDYEMVVDGENLVINRQIQMYAPNSHLQIPLVSGICAASLGGLCPLQVIVGGGEIFRDEQIYLAHKAAAPARYAPCDEILVKNGNTKEDVTAWPPTNVLLQVFENCPHAAPTLAHTHGAKYQYRSVANFATWAFENAQKPYLHASDASVHEIDDSFNAGESGPIGQIGDALPLFNNHMIRQLVKFDGRILPLEPASKLRACNVSATDIGFLKEDAYKGWLQFRKKSDERYASEIIKVYKERERQAAVGYRTFPDGEVPPPSALAGRIMKNEEVEMEKPRGRIGKGIIRVFNKADDRSIRGRKSANDSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R780</accession>
    <name>A0A3D8R780_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08296</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW69899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R780"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017734773" evidence="1">
        <location>
            <begin position="18"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW69899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="72" mass="7234" checksum="78241392890B77D6" modified="2019-01-16" version="1">MKFQLLTLLAAIGLAQASCSVDTYAGTSSETMTCTTSSGAAGQVMNCDSASASAKGCDNGNSLYAAPCNWVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8Q4</accession>
    <name>A0A3D8R8Q4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lysine decarboxylase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_08830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8Q4"/>
    <dbReference type="OrthoDB" id="414463at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016799">
        <property type="term" value="F:hydrolase activity, hydrolyzing N-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009691">
        <property type="term" value="P:cytokinin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.450:FF:000018">
        <property type="entry name" value="Lysine decarboxylase-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005269">
        <property type="entry name" value="LOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031100">
        <property type="entry name" value="LOG_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00730">
        <property type="entry name" value="Rossman fold protein, TIGR00730 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223">
        <property type="entry name" value="LOG FAMILY PROTEIN YJL055W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31223:SF70">
        <property type="entry name" value="LOG FAMILY PROTEIN YJL055W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03641">
        <property type="entry name" value="Lysine_decarbox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102405">
        <property type="entry name" value="MCP/YpsA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW70433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="274" mass="28751" checksum="30F109B3DF4E2ADD" modified="2019-01-16" version="1">MASGGVSPFVKPVTGDDIVITSNGDIMTKTSANGGLIMSNGTPQASLAEKSDTQVKVCVFMGASPGKSEAHLAAARALAQAMADQDIALVYGGGTVGLMGELARTLVSLKGPSYVHGIIPLPLVKYERSSESEDASQNKGIEGVPKYDNYGKTTVVKDMHTRKQLMTSEVLSGAKGSGFIALSGGYGTMEELMEVVTWNQLGIHDRGVCLYNVDGFWDGILKWVEGAVDAGFISTGSSTIIKSSSTAEGSLQALRDYVPSTGRFKLEWGNVGQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R985</accession>
    <name>A0A3D8R985_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Mso1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_08821</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R985"/>
    <dbReference type="OrthoDB" id="2683368at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028095">
        <property type="entry name" value="Mso1_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14475">
        <property type="entry name" value="Mso1_Sec1_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mso1 N-terminal" evidence="2">
        <location>
            <begin position="18"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW70424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="260" mass="26208" checksum="64FD7B1EE09794E3" modified="2019-01-16" version="1">MTSYLSSLLTTTTSRVASIRQNLLASEDDGPTEDDTHLCRVLRAYYTEKGRQFPAWLPPDPKAPAPVAAAPVMSQSSIGSRYGGANMQAVPGGAAAGPGSGLSSLWNKSEAGVPNAGGGSLRAGRAQAAAAGGLSPYQREAVQARPLPSQREGSYQSASPFAGRDSPAAGSASNRLKDRFRSGARSASPASGMSGPRGGSYDTASSGAYDSSYEDSFMPRDSGAGGGGGYSAPPRVAAGLPSGPRAGRGPGLPSGPRGMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCN8</accession>
    <name>A0A3D8RCN8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulase</fullName>
            <ecNumber evidence="3">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_07774</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RCN8"/>
    <dbReference type="OrthoDB" id="5823761at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142:SF1">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017680654" description="cellulase" evidence="8">
        <location>
            <begin position="19"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="9">
        <location>
            <begin position="18"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW71740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="403" mass="42973" checksum="1ECDF6F21E065AA2" modified="2019-01-16" version="1">MKPSNLFPASMFIALSSAQQVAYGQCGGQGWTGLTTCISGYSCIVQSTWYSQCVPSTGSSVTTSTTKASSSTLTTVTTSKTSSTTKTSTSTATGAAATGFKWLGANEAGAEFGTAIPGVYGTDFIFASTAAIDTLMAEGYNIFRFPFMMERMAPGGVSSTLSAAYLANYSVPINHVTSKGGHAILDPHNYGRYNGAIITDAAAFKTFWSNLASAFKDNPNVIFDTNNEFHDEDISNILALDQAAIDGIRGVGATSQYIFAEGNSYSAAWFWNTTSDALKALVDPQDKLVYEMHLYLDSDNSGTSTTCYTSTVGVDRIVGATQWLRNNGKLGVLGEFAGGNNDVCLTAVKGLLQHMKDNSDVWLGALWWAAGPWWGDYIYSFEPPSGIGYTYYDATLKAFLPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDS7</accession>
    <name>A0A3D8RDS7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_08229</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDS7"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="114"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="4">
        <location>
            <begin position="462"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW72195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="588" mass="64916" checksum="DAD8AFA7D92F6713" modified="2019-01-16" version="1">MSSPEKQTLLVQHNKLDSSPATVWSLGRRVKYAMVVLLTASTYLLFGNGSFDTGAGSTSSLKWEPCGEVNKHKLECTRIDVPMDQFNKSASDKTFSIPLVRLLATNTSATGGKSIVLNPGGPGGSGAEFIWRRGEQLNKIIGEGFHLLGFDPRGVNGSIPQASCFVSPEQREEKIFETPWEVEFEAGDMFTRAENQVKACSEVTGEHSLYINTPQTAADMNSILDAIGQEEMYYWGFSYGTTLGQTYAQLFPERVTRLIIDGVSNLDDWYNSFVDEEDLVDTDKCYSEFVRHCFDAKENCPLNSIKDVSFKTANDLKTYIDDFLEALDEEPIPVYLGAKNYGAVTRRGVATNGVFSALYKPTPMWSVLAKNLAQLLSGNATAAYQAYTDLWVSKVLADETNTFVVQNDNWKTGANAPEHGIKPLQNLTMSLPEVSKLVSRYMGSDIYARASWDLPTTHDFHPRYHPEFPRVKTAHPILVLSTTYDPVCPLISAKKAHNSFEGAGFVEQHSTGHCSVSMPSLCTAKHVQRYFYDGILPQKGATCEIDGEYFPAPGSSVEAQSQLGEDDAKLLQALQELAAIGINDVPRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RHW8</accession>
    <name>A0A3D8RHW8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol-4-phosphate 5-kinase</fullName>
            <ecNumber evidence="2">2.7.1.68</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">1-phosphatidylinositol 4-phosphate kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Diphosphoinositide kinase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">PIP5K</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_07084</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14425"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.68"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.68" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RHW8"/>
    <dbReference type="OrthoDB" id="20783at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17303">
        <property type="entry name" value="PIPKc_PIP5K_yeast_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.800.10:FF:000009">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 5-kinase its3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIPK" evidence="13">
        <location>
            <begin position="338"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="68"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="613"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="761"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="116"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="794"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="813"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="846"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="872"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="900"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00082306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW73642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="943" mass="105414" checksum="298AD49BFBEEEF8B" modified="2019-01-16" version="1">MPSFLTDDSGPMLSATRPPLDLPSHIRHSHEKINGNGRTSSHASVKGSLNEGSDIYADAVNGNRLQPNGGMHYDENLNSMTNGRSSMSSYDYRSSRNGSTYSVNGGINGMVENGRKSPSLQNGSARHVNGDTSRNSVASTNGTPQSPPSFDNGSRPTINGDAGPRRISIPAPISTNPQSTGPLTYTSSLVPATPQPAESPARAATSSPHRFSSPPLYSSPTNATTGSSSSSAAYPAASQQLKQRHTLQVPKAGTGRNSRDGDDSVYSTGRFSPPTVGNPRRGSLSLNRRNTQSIHSNLPHDEIVPDEDALRWAEAVRQKRASKRRRKDEEDDDRVVVGTKVDQNHVNWVTAYNMLTGIRFTVSRTNAKLDRPLTDADFEAKHKFSFDITGNELTPSAKYDFKFKDYAPWVFRHLRAKFKLDPADYLMSLTSKYILSELGSPGKSGSFFYFSRDYKYIIKTIHHAEHKFLRKILKEYYAHVEANPNTLLSQFYGLHRVKIPYGRKIHFVVMNNLFPPHRDIHQTFDLKGSTVGRDFKEENLEKNPRATLKDLNWLRRNLHLEFGPEKKRMFIEQMRRDVELMQRLKIMDYSMLVGIHDLKKGNQENLRDKTLQVFQPGGDSPADDPDKGPERGVLMRTPSKLESARKARELRQIIKQEKPIPMGQSSSRMLDEMEENMTKKEFTFYSDDGGFRATHEDNTPGDEIFFLSIIDCLTHYGTIKKLEHIWKGLSHDKRLISPVAPEPYGERFVKFIEGITMSPEEAAREAETNPLSPIANLDGGRPAGSTEQGRRRSGSQTQPIQRTQSSNTPFQRAENEALRSEYRDGRDVEDSRPDPRMIGVVRSPSAERTNGIQGQTLPIVEEAGEASSTGGRSERSAERRPLTPSKEYNGAEYGNRPRTPAKDYIPRLSHESGRRIEGPQNATEKKTISRSSLDKDLPPLPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIB3</accession>
    <name>A0A3D8RIB3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Prefoldin subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_07227</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIB3"/>
    <dbReference type="OrthoDB" id="248120at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23161">
        <property type="entry name" value="Prefoldin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000003">
        <property type="entry name" value="Prefoldin subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="79"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW73785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="14105" checksum="F3488058605C1514" modified="2019-01-16" version="1">MAEGQQRLQALSEEYTSLQQELQTNVASRQKLESQQQENKGVQKEFKSLDDDANIYKLVGPVLLKQDKTEAVLAVDGRLEFIDNEIKRVEKQIKEIEEKTDKVRMEIMQIQSESQAAAQPQAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIG5</accession>
    <name>A0A3D8RIG5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U3 small nucleolar RNA-associated protein 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_07284</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the NRAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIG5"/>
    <dbReference type="OrthoDB" id="10251401at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005554">
        <property type="entry name" value="NOL6/Upt22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035082">
        <property type="entry name" value="Nrap_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035367">
        <property type="entry name" value="Nrap_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035368">
        <property type="entry name" value="Nrap_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035369">
        <property type="entry name" value="Nrap_D4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035370">
        <property type="entry name" value="Nrap_D5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035371">
        <property type="entry name" value="Nrap_D6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972">
        <property type="entry name" value="NUCLEOLAR RNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03813">
        <property type="entry name" value="Nrap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17403">
        <property type="entry name" value="Nrap_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17404">
        <property type="entry name" value="Nrap_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17405">
        <property type="entry name" value="Nrap_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17406">
        <property type="entry name" value="Nrap_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17407">
        <property type="entry name" value="Nrap_D6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Nrap protein" evidence="7">
        <location>
            <begin position="156"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="8">
        <location>
            <begin position="295"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="9">
        <location>
            <begin position="440"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="10">
        <location>
            <begin position="613"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="11">
        <location>
            <begin position="799"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="12">
        <location>
            <begin position="957"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW73842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1086" mass="122470" checksum="1762647540337573" modified="2019-01-16" version="1">MAVNPSKRRKLDHEIQEDSSNEAESKQVSKTKSARLTNHEDGALYSGGSYKSNLFKLQVDEMLAEVKPNYEKRLGFISDELHKLKGLIESIGDRDPLSVQDAMKAFRSCNITIPFPDPKPSLDAAYKLSYARPSKINVSGSYATKTMIKSDSTISIDLIVTMPPSIFQDKDYLNYRYFYKRAYYLACIAAGLQTGENKLEYEYKNGNKLHPILVLNSKAKPGHVTEIHILLAAPEGLFAESKLRPERNAIRNKETIDSESFASVHTPFYNASLRSDCCVESYLKLLHGSSKQSSAFKDSCILGRIWLRQRGFGSSLAAGGFGTFEWSALIALLLRTGGPQKRALLSSGYSSYQIFKAVLHFLSTTDLLKRPLVLETDFLAAKLGLPMIYDGQRGHNILYKMTPWSYDLLRQEAATTSKMLNDSTFDYFEPTFIIRTNHLLHRFDCIVRLEVPESEVTKTLCDAVSGTRNFSLRLYDMLKEGLMDRVTLIHLRETVPERWPLKSPSTTANEQELVISVIFNPANVDRLVDHGPSAEDKKAAAKFQKFWGEKAELRRFKDGSILESLVWPAGSSYSIYQNIVTFLIGRHFGADAIASLEFVGEAFSKALPTFLTSGQLFEALRQDFQKLERDIRNLEDLPLQLRQLSAISPSLRNSSIHPPSFSTLRPLADPADVAIQFEGSGRWPDDIEAIQRTKIAFLLKIGSCLEETNAEIISRIGLENDRQALQNCAFLDIFYPSGAAFRLRIQNDREQTLLERQIKGTVEDHRARTDAVAALAYYKRLFIHLPLLNQSIATHCTRFPFLSPTIRLVKMWFDRHLLSEHFSEEFIELLAAHVFLHPMPWNAPSSAMTGFLRVLFFLSRWDWRLVPLIVDFTGTMTSSDAATINTRLEAWRKVDPSMNRTVLFAATNHDTTGTAFTSNGPTKVAAARMTALARSACKIVKEHGISLDYKTLFATSLDDYDFVIHLNPKYSKTFKELSASKQFKNLEVQSNVDLELVGLDSVETYVHEIQERYGETVVFFRSKTGTVVAGLWNPQYGPRSFKVNLSYATRPLAVGDDQEIVGIDKSTMLAEISRIGGDMVMKIEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIL4</accession>
    <name>A0A3D8RIL4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_07210</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIL4"/>
    <dbReference type="OrthoDB" id="10262653at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.20">
        <property type="entry name" value="Ribosomal protein S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000892">
        <property type="entry name" value="Ribosomal_eS26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047864">
        <property type="entry name" value="Ribosomal_eS26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038551">
        <property type="entry name" value="Ribosomal_eS26_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01283">
        <property type="entry name" value="Ribosomal_S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00733">
        <property type="entry name" value="RIBOSOMAL_S26E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="9"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="115"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="137"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW73768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="148" mass="16850" checksum="318339A84EC1DF91" modified="2019-01-16" version="1">MFSNIFDFNNTTTNNTNNHLGIRQDGQEARVQRSQQEGPRPRQAHPLQQLLSLISTPKDKAIKRFTIRNMVESAAIRDISDASVFAEYTVPKMYLKLQYCVSCAIHGKIVRVRSREGRRNRAPPPRVRYNKDGKKVNPNQAAAKTTQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIP4</accession>
    <name>A0A3D8RIP4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Eukaryotic translation initiation factor-like protein 2C 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_07357</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the argonaute family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIP4"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032473">
        <property type="entry name" value="Argonaute_Mid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16487">
        <property type="entry name" value="ArgoMid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00949">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50821">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAZ" evidence="3">
        <location>
            <begin position="279"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Piwi" evidence="4">
        <location>
            <begin position="568"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="910"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="910"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU361178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW73915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="959" mass="108715" checksum="C3DFEBF08F8EDD6F" modified="2019-01-16" version="1">MELLNYARFDPDTNATKYDSMFASQLPNRPKYNTAGKEIQIRVNQFKVLGYPQKDIFQYDVLIGSGGEKRGLIKTVWESKIVQSRLRSLSQNWIWNGDKIAWCDTRVPRDELRITVDLDAEKGRPPRPDKPNVFYCHIKMIKVVRLAVIDAYLSQKMAFDNAVLEAINFMDHLMRQMPSRHYCAIKRSYFARGGNRFELDNNVEAMKGVYSSLRLCDKIPSFGQGTGVALNVDVANGTFWSVKELHTAARDFCADRNRRKDWGVFHQLLAPIKGPTGPTMSEEFKNLRKMTKLKFTVAHQTEKNRGKIYTIKRFTFPKNFNNPEAARFKYATEGQHAKNTFFILKSSPGATTGEEISIFNYYRKKYGRDLQFPLLPLVETERAGFFPMELCTIAKDQQYKFKLSPDQTSKMIKFAVTRPKERIGAISHGVGMLKWNQDDYLKAYGLQVDPSMSLTKARLLQYPEVQFGSNAKHNPGTQGRWDLRGKRFLFGNKEPLKSWGVCVMEECVSKAQMDNFLKTFIQTYIGHGGNVANKSPTIYVSKRGEDIGEMVGKFRTAVGNANQQMPQIMLYVLKERNSFTYERLKKNMECRFATVSQMMNCAHVAKAQPQYCSNVCMKLNAKLGGTTCKVLDKTAPTNWSSSFFPKPGDPTGRPTMIIGADVSHPSPGSPQASMAALTMSFDRFACRYAAAVQTNGHRVEMITEGNINSMMMPLFHKWIQHVGGGKGPQHIYYFRDGVSEGQYSHVLEQEVTHMKKAIDAKYGQNAKDIRWTVVICSKRHHIRFFPKDGDNVAGDKNSNPVPGTLVERDVTHPFEYDFYLNAHSALQGTARPVHYHVILDEAQVAPNDFHKMVYQMSYQYMRSTTSVSLFPAVYYAHLASNRARAHEDAPSSGGPRGGQKFMEQMQDASNRQNFTGRPPTSQTGSSGPLPTEARPLVPLGAPNNSPEMLDKIRCGMWYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJ57</accession>
    <name>A0A3D8RJ57_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3074 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_07525</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJ57"/>
    <dbReference type="OrthoDB" id="6423603at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024500">
        <property type="entry name" value="DUF3074"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40370:SF1">
        <property type="entry name" value="DUF3074 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40370">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11274">
        <property type="entry name" value="DUF3074"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3074" evidence="2">
        <location>
            <begin position="123"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW74083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="329" mass="35880" checksum="D39227877F47927D" modified="2019-01-16" version="1">MALQLGPLVRLEGLSISQLPLGGKGVEPSNRASNEKFSDGSGAVAAPNLTTFVTKILGESIPFIDGVAPKAGGDSTWKTKGSPKNYPHSDAPVHLFEKVVAGKDLDKIEGMGSLHADRKDETWFCRRSCHQNKAEKGTASWEEFTHSFKEHHAETEDAFTPTVIGAREAIKWDTTGIEVEAHGARWTNLTLVVEEMKHKIDPKPLKNRTFPILQLAAELAGVKEFLVISIPLTDFEKSPYAEFARDKSLVVAAYASIERIRELPSTGEIEWIMATASDAKGVLPQWMQNMAVPGAVAKDVEMFLSWIPTRRSGPPANGQSAKPDEPVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJN6</accession>
    <name>A0A3D8RJN6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_07590</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJN6"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050888">
        <property type="entry name" value="ZnF_C2H2-type_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24406">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR CTCFL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="3"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="32"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="90"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="119"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="148"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW74148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="333" mass="38056" checksum="290E7F41AB8A46B4" modified="2019-01-16" version="1">MSFRCGPCDRFFDSDKALQQHVQDAPAHAPSFNCRPCDRSFSNEKALQQHLQDAPAHVPSFNCEPCDRSFSSDEALQQHLRDAPAHAPSFDCEACDRTFGSEEALHQHLRDSPVHAPSINCDDCDRSFNSEEALRQHLRDSPAHASFFDCAPCDRTFSSAEALQQHLRDSRIHQQDTETPLNMFFRSFPTFDYDPSLPPATSYASLREHKGWRRGSAASADAWTRYQEALESELHMWFGAENDLTAWHALCRAIGVKPLPRTCEQCEETVRRTHVNIIDLIEWGRSDNEDKVQTFRDVAQLRAYTKETRKIFSNTFDGEGGNVVLRHLLRKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RK49</accession>
    <name>A0A3D8RK49_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Elf1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_07653</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RK49"/>
    <dbReference type="OrthoDB" id="648285at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF74">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G02010)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="473"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="52"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW74211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="539" mass="59284" checksum="1EF6C6308C3ED646" modified="2019-01-16" version="1">MSKEHTSDSHHETAIMSTSAMTPNYGWLERKLKPTTVSARYPFKGKALLYTTCAFGSLGDALFGYNSGIMSGLLVNPIFVSRFYKNYGGADGTTDNVNATITGISVSCLQLSAALGALIAGRLGDMIGRKKCVRIGGIIYFFSAFIQIFAPDFGTFVAGRTIQGLGVGFLSMTVPIIQTEIAAPHARGLMVGIEYTFLIAGYMLSCWVDYGFNFLLPSNMSWIGPFIIQLALSFILVIMSFFLPETPRWLAKNGFEQEALQTVADLHSNGDTSAPHVQSVFKEIHEAVRYEESLGQSSWLEMFTRYRKRTIVGITVQMFAQLNGINIISFYLPSTLATAGFDNRRALLYTAANALPYTAATVATWWLADHWGRRPLLILGGVLMAALLGIVCAFTEANLGIQTKANGQYAFVMLYNIVYGFTWGPMPWLIPAEIFPLRSRSKGMALATFSNWIFNFIIGMVSPDAFRGIHGYFYLVIASFCLFSAGLAYFYYVETAGHTLEEIAVAFGDKAFVDNDEDVIASAGLDKTTSHQQSYDAHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RNP6</accession>
    <name>A0A3D8RNP6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GET complex subunit GET2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_06401</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RNP6"/>
    <dbReference type="OrthoDB" id="5393181at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028143">
        <property type="entry name" value="Get2/sif1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28263">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28263:SF1">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08690">
        <property type="entry name" value="GET2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW75580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="32616" checksum="873802C8ADAD1177" modified="2019-01-16" version="1">MAETPPATLSEPSTPPSSASEQARIRKERREAKIKAGGSARLDRITGLGGGVKRDPPPQPTASTADPEEVDISQHYYEPKQRSIRPDNAATPPQQISDDQLRQLMLGFDPATATPPPPGANPFAGFPGLGGGMPGMEGPGAEDPMMKMLQQMMGGVPGEGANGMPAFPGMTPQPVAGGSPYAYLWRVVHAVFALSLGLYIALTTTFSGTKLDREKSAIAAEFSQVHFFWIFATAEVLLQSSRYFVERGKSVPMAGVVGMVVGFLPQPWKGYVELMGRYSRIWTTVSGDAFVCVFVLGVCAWARGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RP36</accession>
    <name>A0A3D8RP36_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">MFS general substrate transporter-32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_06634</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RP36"/>
    <dbReference type="OrthoDB" id="546893at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050375">
        <property type="entry name" value="MFS_TsgA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702">
        <property type="entry name" value="L-FUCOSE-PROTON SYMPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43702:SF3">
        <property type="entry name" value="PROTEIN TSGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="153"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="219"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="242"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW75813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="381" mass="40932" checksum="8A4CBBE1345BA871" modified="2019-01-16" version="1">MVFIWGLCLYGVGALVAWPCIVYRSFGGFCAAIFIIGNGLGSLETAANPYITVCGPPRYSEIRINISQAFNGIGTVVAPVLGSYVFFLKTGDDAKALRNVQWVYLAIAIFVFLLAVVFFFANIPEITDADMEYQATETHAGLSVKPFRKQYRLFHAAFAQFCYTGAQVAIASYFINYVVQTRPNTDSALAAKFLAGAQGTFALGRFVGVGLMKFIKARYVFLVYLTCCIIFIAPSITQRGNIGMSMLYLTLFFESICFPTIVALGMRGLGKYSKKGSGYIVAGVSGGACVPPLLGAAADANNHNVALAMVVPLMFFVAAESYAIAVNFVPAYRDVADKFATAEIGLRDVGTVDEESSPGVVAGDEKIAAAQHDETVTTTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RP50</accession>
    <name>A0A3D8RP50_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MFS monocarboxylate transporter-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_06650</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RP50"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF230">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="75"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="382"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="417"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="77"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW75829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="481" mass="52765" checksum="430BE4035365F879" modified="2019-01-16" version="1">MARNVPGSTSPLELRNLPSPAMLQPHSTATTPADSKGAHAHSAPAPPVDQLPMPYDLEPSTTIASRIHTFPEGGLRAWVVVFGSFCVIASTYGLISSAGLFQSYWQANQLSAYRSQDIGWITAVNVFLNLILGVQIGPLFDKYGPRYLLLVGAVFYVASLLLLGQCVKYWHFMLVYGILSGMSSALLTTSSLAVVAHWFEAKRGMASGIAFVGSSVGGIAFPLTLSPMLEKLSWAWAMRIIALVVAVLVVIGNLCIRGRLPPRKNGGAIDLKCFRDMRFTWATVGISWSPWLDTDVYHHARLQRADELQRHRDPQCVSLLVQDAQRLDELIPGSIRGSALGRSMSGWFSDRYGRFNTMILTLIWSLVAVFGLWMPVGNHVVLFYFFAPLFGFGSGSIISMAPVCIGQLCKADEYGQWYGTSYSLVSFATLLCIPIGGALLPVVGAAGFAAFWGGVLILSLFSFMMARWACQEYRWQWRAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RQ44</accession>
    <name>A0A3D8RQ44_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Alternative oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_06825</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RQ44"/>
    <dbReference type="OrthoDB" id="20368at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW76004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="435" mass="49275" checksum="F02D9F44589FE1A2" modified="2019-01-16" version="1">MLRIHAGRKRKHVVPVVAITYLIILWFWILYWGSLPSLNLLSSFSGPSDVFDFSPLKSEAIQKVCAGVEWNPDIVFTCDRSVGGVGNIRNSVLHCVRYAISAGASLVIPRIVIRNPKDVAIIHTKERVELDYMFDRHHFVESLRLSCPQLRLYNTITDVPNYKAAQKKVGTTLDPARIMERVPHYGLAHPEDFQQRFYEWLKKHFPDATTGTTVVALARLYLQYPIYTDSEVFALSFGEILKFRPDVRRLATLALVKMSKALSLPKLLIGNYAKKAFFGAHLRTEKDAVNGFTAFELSAYEAQSKLYLEQAASTNMKVLYVASGNDTEINRFADDARIANMTVITKHDLLEGEDLKKLNALTWDQQALVDFLVLSKSSYFAGVGHTSFALNIALLRHQWARAKNHLNGPQQISDDLSVIFGKVHARMEYVNNMWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RQ54</accession>
    <name>A0A3D8RQ54_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_06835</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RQ54"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="265"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW76014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="32442" checksum="D69E87851B926C5F" modified="2019-01-16" version="1">MDIEKSQNERLLSDRESSEASGPYHLQRPVAYSSRIHFLILYTIISIQALGMLYLGLRKQICKDPSIGDFYSPAQDLVEYETVTFPESMWEKSVYMSREHDGIPDDITDIMWNQLYHFGNLNWITSEEAARIPNRTIAVPGEENRYLMELDVFHQLHCLNTLRKTLWPQRYEGHFFDWIGSDGQRNYTSGQAHHYDHCIESLRLSIMCHSDIAAVYWDYEPERGIPLPQETEPHTCRNFEKIREWALGREVESIKWPKGPPPEEMYSRPKESELAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RQD1</accession>
    <name>A0A3D8RQD1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_07026</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RQD1"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF198">
        <property type="entry name" value="AZOLE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="541"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="75"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="566"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="570"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW76205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="586" mass="62273" checksum="A955C8481FADEA8F" modified="2019-01-16" version="1">MATPTATAAEHPPEHPTTRISGEADGNGPDASTTSSGNDTHETTVEKIPEPAVDERPDGLPEGSQYPTGLKFWLLMFNLGAVIILGAIDMSIVATAVPSITDHFHTVADIGWYSIAFRLSQCACQFLYGKAYKLFPIKRVFLLANGFSFLGSLLCATAVSSSMLIVGRAVAGVGTAGLDAGAFIMLVQSTPLRKRPTFLGLWAAIEGISTILGPVLGGAITQTIGWRWCFYISLPIGGATLLLTILCFSETSKAVDVARLTFQEKFWQLDIVSNLILVSALTCLFLAFSWAGTKYPWRSTRVIGLVTTFGVLAAAFIYNQFRRGDAAALPIRIVKRRTVIASLVFVTFLNSAGNVLEYYLPIYYQAVRGYTPAQSGLLMLPILIAATIGAIGSGIGTSVCGYYAPFMIFASVTMPIAAGLITTFKINTGLAKFIVYTGLSGFGYGVGSAGPSVAIQTVLSDGDVPVGLSVLIFGAAFGPAVAIAVAQVIFTNQLSKYLHTLLPELGGASLDSNGLAELVTQVPPAKSQEVLQGIDKSVTHTWYLVIALALAMFFGSLSIEWRSVKKEDPNQGTESSTQTLELANQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RQE7</accession>
    <name>A0A3D8RQE7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter-18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_06987</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RQE7"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF40">
        <property type="entry name" value="THIAMINE PATHWAY TRANSPORTER THI73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW76166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="523" mass="58295" checksum="3C7FC1A3ABAF5D14" modified="2019-01-16" version="1">MTQVPPSPMIPLDDEKNFRINGVGAGINVAPIVDEDVGASDGDDALGLAGTHAHNFDEKYFLRLRRKIDLHVMPLLVFVYFTQFLDKNILSYASVMGFPVTGIWYNDVAQAFYMGFLIWMFPTQYIGQKFPIAKYLGCHIVVWGCLVMLHAVCSNFSSFYALRFFLGMLEACVSPSLILIVSMWYKQNERASRIAWFYAGNLSTSVVGGGVAYGVTFFKGSIAPWKLLYLILGLLAIINGVLVIIFLPDSPITASFLTDEERIAALERVRLDQAGTHNKRIKRYQIVETFKDVRTWIMFIIIMCIGVPNGGNSAFSNIITKSFGWTSRQTLLLDMPRAAIGGFAVVAVGWLSDRINDRMSLILLFTLPTLIGMIIMTTMQHSGQKGVLQFAQLFQNLSAPGFPLCYAWNASNTGGHTKKVTVNSFTLFTFGAGSVIGTYIFLPRDAPGYIPGKAAIVVLTAVMMMCCAVMAYVNVRLNRQKKVALEKLIADNGWTEEDVEREREKAGFLDLSDRENVFFTYTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RQG4</accession>
    <name>A0A3D8RQG4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_06945</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RQG4"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF315">
        <property type="entry name" value="TRANSPORTER MCH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="40"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW76124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="52222" checksum="BC1F07944217C66E" modified="2019-01-16" version="1">MPFKKKSKPSQQDPAPTLAVSHPSAADLDIPDGGYAWVQVFAIFLVNGFTWGQTASYGVYLAYYLDSNTFPEATSIDYAFIGGLQFALSLLVAPAATITARRYGLHQCMLVGIVLQTIGFICASFVHRIWQLYITQGVLIGGGLGFIFVPATAILSQWFDKKRSLATGIASAGSGIGGLIFSFGSNAIIHNVSLGWAFRITALICGAMNLTAVALIRNRNKTIKPPQLGFDTKLLVRYDVILFLAWGFISMFGYMTLLYSLSAFATSLGLSKTQSGNISAFLNLGTALGRPAVGFLSDRFGRMEVAGSLTFVGGVFCFAIWIPAKTYAVTIFFAIVVGAIFGVFWMTVAPIAVNVVGVPEVPSMLSIYWLVITAPTLFTEVIALELRRPQMSNQYIYPQIFSGISYIVASVCMLELRRVTRKKWRAHHASAVLETTDTMTTIPPGADPERGEKEAQVFKPEVAPSHTVQLEPAWPTAKASAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RW07</accession>
    <name>A0A3D8RW07_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7727 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_06030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RW07"/>
    <dbReference type="OrthoDB" id="2110422at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056144">
        <property type="entry name" value="DUF7727"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40629">
        <property type="entry name" value="PRO41 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40629:SF1">
        <property type="entry name" value="PRO41 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24853">
        <property type="entry name" value="DUF7727"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7727" evidence="2">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW78178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="143" mass="16084" checksum="948AF5F21C47CE6D" modified="2019-01-16" version="1">MGGLIKNHWARLIVLTAATYQVAAALEGFFWPKIFWDFLTHNLDPIVKPIPILQVINLVFGIFMLAWEWPLAFMAGSSLHRSIAARLVFLPLTGLAAALLYQGTNPAIYYTIAMGVYFWAYSDGEIICETPWSLPKRERPGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWT6</accession>
    <name>A0A3D8RWT6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_06242</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWT6"/>
    <dbReference type="OrthoDB" id="5385072at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW78390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="377" mass="39637" checksum="A9B7BD20D7F74129" modified="2019-01-16" version="1">MDVRRKPIPQIYTSQPQPISVPMYQQHSRTRTTSSSAFPTEVYSPPYAQNNNMTMPTNYTSRRTPSTNTFSTTNSGNGPFPSRQQSNSQNDLRRSTSSRSGGTTAPSSYVALMRKQKATVWCDRAQHEDPRLLAAQRAAKKRATMEVTGGLSAGGRTSTGGSGSLAGSNRVTAKIRHHGKAGLVGYSPGDLVGGVGGVPMRLSASEVEGGDSDDDADSTGHSGYALYHQRTGSGRSSVGSGGRRGLTYSRQSGASSSAGRWSAGHTPPDHEPRIEDNAETPLASKQQNGSSTYFASEGDGTAGSMGSGSSGERADGVAELSASKLASNNLLRSQTGTVKSLRHGGYGDLARRGSVDDRTMTMSAGRLYIANPDEDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2L0</accession>
    <name>A0A3D8S2L0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_05217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2L0"/>
    <dbReference type="OrthoDB" id="5374569at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW80519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="370" mass="40892" checksum="06935E0131A5A3B2" modified="2019-01-16" version="1">MPRRLPWEQGTSSTIAKRATKPSAAAVRKRRKLDDPDNVASEDDGVNPKKKDPTRNPSTSPPAEQPEPPVERFMDEGIDRDDKYRMVEDEFLSTAKRWTVHLHTAEYHRQKRLARSKNATTINSISRPVTQKMPQQTRRKLESVDRSKAQRGMLLGLLGKKDANGEDSNSDEADDLPYVGTSLHGLMDGPRKSAGSLTRFGSITSCTRAAAGFQKPTQYLSQTPKHSTSSQPRQIMEKSSMSDSATESSDDDDDLDGPIAAPIFNSTMGTAAVTKNKDVFASYACPMAPVVEVPKAQIVEKPVSRTAADSLHFSNKSATVVKSRNPFEEADTTAPDHLSKVRKRLAQARFLKASKDKKEQKKLDIVPTFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3E7</accession>
    <name>A0A3D8S3E7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_05388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3E7"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="385"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW80690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="880" mass="101088" checksum="5007B94796340A7B" modified="2019-01-16" version="1">MAPSTENALEQAINAIFNGILDTFHDTDSFGREDSPTIFIVYAHHNTKVVGKAAGDHISTELIDILKRVGSRTYSDRYPSERVYWASRDSDAFHNIIGNQSIILPNSRSEERRNKVHSSDKVILCWSEMLEEYYKDEGMKKYIEAIKTFYDTNGRHLRCNDNDKLKDELKQIAATYSKDNPAFHHVLTEMAFLEIRYEEMRDHGIVPVQINGDSDLPKPEFLGNNTDLWQNPPDVDKSLDPNENVIYKKKRLHLWVFKLFKKLFVNFNQQIRIDEFEACYKACIAKLEKQLEPSSDITSLPTLKELEDWPDLKKHVVAKITEAFEEISRAHQRAQRTAPTVGNRDRAEKNQEIHRLPVAEASFNDDKINRDKRVCLENTRVRLLQEIENWSVQDGGERIFWLNGRAGTGKSTIAMTVCKRLNQKGRLGASYFFSTHQNGGSSREFFTTLASDLANVSVELKTLISNAIADHHDFAKKRFEEQWRWLVLEPLKTYQSSGAPLVLVIDALDECVDECDATDILELLGGDENPHLILRILITSRPGLLGFDRILNNTRRVDLHDIQDTEKDILLYLDAELSRIRASRKARADWPGKTKVDALAQKAGDLFIYAATACRFIDVDLSYDRRLTSILKEDRIGMQNLHGIYMKILETAIPDGFLEEERNKAQGDLNEIVATVLVLFNPLSISGLRKCLPRSITSYEAQGYLRRLGSIIAVSGEESQVRIYHLSFRDFFLDVKREDKTFGASEPEVHCTLVSRCLQIMSGILKMDVCNVGESDYLSSRINQDVIKKCLPEHVQYACRYWIAHLEQSDNFPHDEVLVFLQEHFLHWLEALSIMGLVSEGVIMINKLYNMANLKHKQELFDLVYCRDHASSDLPYYCYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3V3</accession>
    <name>A0A3D8S3V3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_05643</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3V3"/>
    <dbReference type="OrthoDB" id="3532245at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW80945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="294" mass="33791" checksum="D842498711DA9F07" modified="2019-01-16" version="1">MPPRKRTADEMSIVEETCKCERHSTQEICDSENHLGYLRRQRETLSSKVLVTSPMARVKVDHPAATFEVCQGILEINSGYFAEAFDRWRVTKRRSDHAKPRTPTAWLKSADWKLEDLDASCSHFISWAIIGAVDWSQCPLQHADVLLWQFGNEIRSPEFQDYCLDHLRQRIVQGTVTWPSPEEAALIYKITRRGSPLRALVADSLASKNPFQTREDVQAWAALIVEQQELSRDVLKAGRMDWRDLRPVHNWYREKYAVDLRTAHCLPKKVCGFPTRGEDHGGVGASRSHRRLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3V4</accession>
    <name>A0A3D8S3V4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein-11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_05548</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3V4"/>
    <dbReference type="OrthoDB" id="191979at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF285">
        <property type="entry name" value="RETINOL DEHYDROGENASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="374"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="377"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="401"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW80850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="411" mass="45591" checksum="70DD32042297436D" modified="2019-01-16" version="1">MPLPFFADVVFGKVSWFPELRTVLLVSALVLVVGAIKWYSMGAFNTSERQMHSKVVMITGGTSGIGASVVLELAQRGAQIVLLTHQEPSDFFLVEYIEGLRERTGNEMIYAEQVDLSSLHSIRKFATKWIDNAPPRRLDMIILCAATLTPPGKNRAVTKEGLEESWMVNYLANFHLLSILSPAIRAQPADRDVRILFATCASYIGSPIIGNGDDAMKVKEWSPAKAYARSKLAFTIFGQAFQKHLDAYKRPDGLPMNARVIFVDPGYSRTPGMRRWATRGTLWGLGLYVLLWNNAWLFLKSAEGGAQSFLYAAMDVTLGRGPGGKLIKECREMDFARVDIRDEEVAKKLWEGSEKLIERVEREEAVRRALEKKEAEAAGVGKQAEAAAADATGSGTDAKQSKSRRQKKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S453</accession>
    <name>A0A3D8S453_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LYC1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_05569</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S453"/>
    <dbReference type="OrthoDB" id="2020070at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055100">
        <property type="entry name" value="GNAT_LYC1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053013">
        <property type="entry name" value="LAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815">
        <property type="entry name" value="LYSINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34815:SF4">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22998">
        <property type="entry name" value="GNAT_LYC1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYC1 C-terminal" evidence="1">
        <location>
            <begin position="168"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW80871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="374" mass="41819" checksum="FFF7105B60745ABC" modified="2019-01-16" version="1">MGSIDLPDWQSPSLALVNPTFEEQIQVWSANSAAWKGPLTKEVYIEREKYLTNVPLNCEKGITHWILVDSTLPPDQRQILASCESLRKRAFVAQGGAVKEVITHGIGSVFCSPKYRGRKYASRMMAEVGKVLKTWQTEERDCKFSILYSDIGKSYYAGFGFKPFPSTHIALPPSSDTVIGEAVQPLQASDLPALCAWDEASIKSQLADAKDGKIHVAIIPENDQMQWFHLREEFLCKNIFGSSKSLPTVKGALAGTPGSRVWAVWTRSYYGPLVPESGNTLHILRLVIEDESAEVSNSQALKGILEFAQREAKEWVLNDVELWNPTPGLKKLVDLTGLEHSEVVRDKESIASLMWYGEEKEEVVWVGNEKFGWC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAT3</accession>
    <name>A0A3D8SAT3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_04980</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAT3"/>
    <dbReference type="OrthoDB" id="2213137at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF287">
        <property type="entry name" value="MFS MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="177"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="209"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="317"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="345"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="5">
        <location>
            <begin position="253"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="25"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW83489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="459" mass="50469" checksum="C7F3C539E479A1CD" modified="2019-01-16" version="1">MAEINAADNVELRDAAELQERSDDVQQQQEASDEATGQSLPPCDGGMAAWKLLISAFVFEALLWGFPLSFGVFQNYYSQLPQFAHHPYISVIGTTASGICYMGAPIMIPIVKRYARYRSRLIWFGWPMCIVALVAGSFARTLGALIFTQGVMYGLGFVIFYYPIISMVNEFWITRRGMAYGLLCSASGVSGTTMPIAFQAMLNKYGYPITLRAIAIGLVILTGPLIPLLRGRTPVSEVSVVARTDWRFLRVRLFWIYSASNLVQGLGYFFPSLYLPSYATSIGLSSKEGAALLAIMSISQILGQMSFGYLSDRKLPLNLLIALSTIMSTIAVFACWGLAHTFKLLLVFSMVYGYFGAGYVAMWARMGTAVSEDPTAAFAAFGLLNLGKGVGNVLAGPIGGSLILNTVDVQRYAAMKFEAVVLFAGFCMLASGSIISLYYMKPLRDIFFRLFEKARIEHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAT8</accession>
    <name>A0A3D8SAT8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_04968</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAT8"/>
    <dbReference type="OrthoDB" id="3266505at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF6">
        <property type="entry name" value="PROLINE UTILIZATION TRANS-ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="5">
        <location>
            <begin position="124"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="16"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW83477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="635" mass="70349" checksum="BCE810B63EE9AB5F" modified="2019-01-16" version="1">MDHMNQSDQAREQLPQRPTVSGTPVQKQSCPESNGQSLLPMNSSKEVSRVKVHNEHVSTWAFSDEVRQVLEPRSGEQPNSSRSGAKVSYMICPQNETLSDTSALNLPPKDYIIHLAQIADFHLNTNYLVFDYPAFLDQLKNTPLQSLKQASEVWHVKLLTVIALGRLFLGRGATSFGPPGIREFLQGVNALPSNVVISQEPLMAIETLCLLATYAEAADMHNAAYLFSGQASRIARSCGLDKRRDLSKDLEPTGQDYKQNLWWTICVLDQKRSATIGATVDYQVQVNDSLLSSHRHPGSISSFALQFNLLVANQLTRIMTAFSKHANVGTMSAASINEIIVELVAMQRLGKETGNMPPLCYERSLQTVSRPVATLHLLYYHCVVIATKPILLHLMKLPRNENDHEASTSGSLEPAFAIMRTCVNAACCSLNIMSALREQNLLEIFSFCDLEITFLAALSLVIANAVTPNITESSFIKVAKDVLQDMSHGGNIPATLLRSELDDVLKLMPNLSPLYGRARHSATVRRPTAMVEDGRVLNNAILHVIEIQPAGKQSHYDPSFRPETAPGISMGNQQPRHEAREATTLIHNPSWRPSLPQANNGMPPPPNNLYIHNFDPVEHGFTFDMEGLQWLDNVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SCM6</accession>
    <name>A0A3D8SCM6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_05019</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SCM6"/>
    <dbReference type="OrthoDB" id="10006023at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005948">
        <property type="term" value="C:acetolactate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003984">
        <property type="term" value="F:acetolactate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07035">
        <property type="entry name" value="TPP_PYR_POX_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045229">
        <property type="entry name" value="TPP_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968:SF166">
        <property type="entry name" value="2-HYDROXYACYL-COA LYASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18968">
        <property type="entry name" value="THIAMINE PYROPHOSPHATE ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="7">
        <location>
            <begin position="6"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="5">
        <location>
            <begin position="191"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="6">
        <location>
            <begin position="395"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW83528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="567" mass="59666" checksum="BB18FC046E53D004" modified="2019-01-16" version="1">MTTPVTVAALLAERILNTGTKTLFALAGATYAPLLMAFEDAGGKVIGGRHESGTVGAADGYARRTGKLGFALIIAEQGLANALTAILTASQAGTPMVVIATRFPDGWIEPSASLTVDLHEFTVSSIKFSRTVPSPERVNEYFQAACKAAMEGTPGPALLIVPMDMINKVVQAPPMVAIRPGSLPIAEPTQIASAVSAIAKAERPIAIVDEGCVWGGGDAAEAGLNTLAALGIPVLGSSLGRGIVSEREPCGYPWPYAQLAASLADVVIVVGAKMTMWFGYGKAPRFNANARFIHIDSRAEAIGRNVPAHIPILAHPGRTIAAIASKLGEDGFRHDPQWLVDGLAERKDKLASFLNREEASIHQIEIGAALDTTLPEDRMIVCDGADILNFTLGCLRIHRPRSYADHQPYGAMGMGLPLAIGFAAGEAEMASDHGTSPIPTTYVTGDGSVGFFLAELNTMRRANLFIIAVVSNDSMWGTEYHGQKVVYGRTSNTELGQSDYAAVARAFGCSGQTVSDRTALVPAIEAALAYKGPSLIDVIVDPMGGAVRKTDPLLSMIIFEEVAKKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SG74</accession>
    <name>A0A3D8SG74_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inosine/uridine-preferring nucleoside hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_03670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SG74"/>
    <dbReference type="OrthoDB" id="432381at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008477">
        <property type="term" value="F:purine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304:SF56">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G11790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="4">
        <location>
            <begin position="5"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW85345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="242" mass="25837" checksum="9E968877E457FEF9" modified="2019-01-16" version="1">MQKKIIIDTDPGVDDVLALLFTLSHPAELDVQLVSLSFGNVSLKDCFRNAATVFNALNTLGLPGPHAVPRTSPVNLAIGHDKPLLAADVVDASQFHGADGLGGTHETHPQYTAQRWLLDFERSSPPTTAVDDLKKGYTVLPREASEEILHLLRTNEPDTITIVAIGPLSNIAKAALLDPETFSCVKEIVVMGGVVEQDGNATPFSEFNAFADPEAAAVVFATTNVPNVATPSFLGVDWALFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SH50</accession>
    <name>A0A3D8SH50_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_03799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SH50"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF11">
        <property type="entry name" value="HET-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="70"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW85474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="230" mass="26038" checksum="A5D12455BB741590" modified="2019-01-16" version="1">MRRSPAPSEGCLPSVGQSRTLNPFPLRPRIAKSDTGHPELSESMRLLEMKCPDEFSLIQIATHNTLPCAILSHTWTDQEVTYQDLISGAGKYKSGYEKIKFCGEQASRDGLQHFWVDTCSIDKSDAAELSRAINSMFRWYRNAKKCYVYLADVSTPGDNIDDQAHQSTWEVAFRRSGWFTRGWTLQELISPATVEFYSKEGTRLGDKKSLEKLIYEITKSSSGSTRGFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHT6</accession>
    <name>A0A3D8SHT6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_04056</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHT6"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="282"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="4">
        <location>
            <begin position="543"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="802"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="835"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="868"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="901"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="934"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="967"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1000"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1033"/>
            <end position="1057"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW85731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1057" mass="118878" checksum="0FBBA966A438DC34" modified="2019-01-16" version="1">MSFALENVARLKPEIRLAQAISEFEADLSSNQKASLHTYRSQIQNVPLAPSEVMRLTAEIDRSASSRNVSRQCFGPRMTNFLYAVQQFASIGDVMVGGSQNLIACGVWAVVRMLLLSIVTMSSYLEKLSSLLMDAGRSAPRYQEIVLVFPRSKPLQSYLAEYFITVVDLCHTVFKLAHKSTVRWFVSTLDDSSLKGYQSDFDRWANLIRDEVNTLVAKRVEKEAQANTHFRALMGKASSSVSLEQKLKTRLRILESCSTYDYETPWKQIRKVGNATLFNQIADYQDWRSQANSSTLFYTGKLGSGKSVLLANIVDDLNLYVQRKDVVTYFFCRYDISESLKARTIIGSLVRQLLRPISELDEAAKVFDDTVLAPDFEYMFKLLEHVIPNAYKAYFILDGLDECDYSERSILIPQLQRLQDRFTLLVCISYRLEPDNALRLKPEEFTTPRSISMSEDNPDIEDFILNELENCLQSSTLVLGDPSLILEIRDALLQHSQGMFLWVALQIKSLCAMKTDESIRQALVDLPKDLTETFLRILARVEIAGQSYQRQILELVTVAQRPLHVNELREALSVVPGNTTWDPATLLNDIYSTLACCGPLVIVDEEELTIRLVHHSVKQFLLTKFNPTTYTGFTIGEAHKTMTSIIVTYLNYGIFGTQLSTIVSPQIMTESVPSGIIRSTLGSSLVVRSLALKFLRSKTPNYDIGQTLIESRKLFKDRLVSDFHFYSYAKSCWQQHMLCTLELEPKISSLLLRLLRNGVVDASTRDDHGDTLLSQAAERGNEVIFALLLETDQFETDLKDIGRWKPLHLASEDGHINIVKLLVEKGADINAADMNGRTLLYRASENGHIDVVKLLLEKGADVNATDKNGWTPLCTASQHRHIDVVKLLLEMGADVNAADENGRTPLYWVSFRGHVNIIKLLLEKEADINTADKRGFTPLHRASQDGKADVVKLLLEKEADVSVADKSRWTPLHRASENGQIDIVKLLLNKGADVNAADENGTTPLYWASFRGHVDIVKLLLERGADVNVADKTGWAPLHWASKNGHVDVVKLLSSRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SI08</accession>
    <name>A0A3D8SI08_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_04294</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SI08"/>
    <dbReference type="OrthoDB" id="4137815at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW85969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="125" mass="13732" checksum="60B3A7010E91EDA2" modified="2019-01-16" version="1">MQAQASMYRTAALLICHRMLHPIGTFDDAALQYAKSIMNDFSNFSALVPPGTKLQNVTFPILIAALEIPNVPKETWENIALSAAAPTCVAKMLAFIEYVWVERGLGFTDFILNLVDTGPDFDAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SI51</accession>
    <name>A0A3D8SI51_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04334</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW86009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SI51"/>
    <dbReference type="OrthoDB" id="3555317at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618:SF1">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40618">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW86009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="376" mass="42119" checksum="39A01C19E161A819" modified="2019-01-16" version="1">MSQTQDSSRLLGREQAAERRRVKQRSTQRAYRTRRENDISSLRRRVDEMEDAIEETGKIILALTDTLLNSSILQQYPQVTPLLVGAMNSCLSLAKLCHPHSTAEDISLGGNADDQNRSVLPEPPQEYLWWNGIFSNILTKKNEDALTTALTIQDSQPAVLNELSSSPLSQAVPATNTTDSNADNIFYKSSNSPIKPMSLTTNFLVPPFPHKEQSRFSQVLVQRCFRNGYQLLTDPFTEPTRINQVFGSQFTNNDRGRMAGYLWHGLLDKGENIIQQLQGHIPSSFYDGSQQDLAYDSVISNDQLVSADGIQELLWKTGISIRNDASFLEVESLSSMVNFDLKSFVIFLCNAPVCSGLEPMFPSHRVETALRLASVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SIE1</accession>
    <name>A0A3D8SIE1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SIE1"/>
    <dbReference type="OrthoDB" id="3563016at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW85944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="357" mass="39339" checksum="90D9084F6B1B5492" modified="2019-01-16" version="1">MSLTESPQSSGDYDDEDSDLEAPAGIEALRKAKQDVITSLTQDISDPSQQEIALDEPSGCYTAVEMNKDNAVLIAATATPSAAQLAQLWWRGFAKLQDTELESSESLAAAWNQSRQYFQTVHAAPAESASDEQVAVLAVHRLTRALAIIPVDLHNEALSGSANVSQSVGRISDIIKVIQVTLKFKIGAIAWVCLGQAVLVCTRSKMKSPMQIVLSHLADIVTLIARYNVMESMYQQWPNMSLEKNYEDSLVDLCAHVLRYLSHVITIATLERAEGAEQRLNESMKRIEEADDRCRGFKVTIIEASVQRGTKRSVQDVEDDDSDDSNDNEIGVEVEREKSGSCKRLYLGEGNISYRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SLT4</accession>
    <name>A0A3D8SLT4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF5672 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SLT4"/>
    <dbReference type="OrthoDB" id="10025998at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043729">
        <property type="entry name" value="DUF5672"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18922">
        <property type="entry name" value="DUF5672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF5672" evidence="1">
        <location>
            <begin position="122"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW87236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="304" mass="34346" checksum="8F734D21DF9D1969" modified="2019-01-16" version="1">MDYGVSKRVMVLAFTLLAFVWLLKLNKNYLGLAPSGDTPVAPTGVSASPNKNVYGHITNKVAVITDTQYTPRLIPLILHYHSVLGPDWPIVFYTSQETLTQHLDPNSKQASAIWSRAVQDGRIQVRTIPEEFNLTSRDGVNIYLSRPWLWESLAPAQHVLIFQTDAIVCANAHRSLDDFLEWDWIGAPLHATDAWYNGGLSLRNRTMILDILREGNNWENETQSGAWTFGGEDAWFSRKMDARGAHLPPAQESLQFACEFDWHVDQQKEPFGYHKIHKNAPSKLDEIIQWCPEITLAAPGKLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SM45</accession>
    <name>A0A3D8SM45_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Patatin-like phospholipase domain-containing protein</fullName>
            <ecNumber evidence="6">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_03087</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Lipid hydrolase.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable lipid hydrolase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <topology evidence="6">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the PLPL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="6"/>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SM45"/>
    <dbReference type="OrthoDB" id="10049244at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07230">
        <property type="entry name" value="Pat_TGL4-5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF10">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="8">
        <location>
            <begin position="241"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="598"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="704"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="5">
        <location>
            <begin position="272"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="606"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="648"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="707"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="717"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="274"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW87393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="809" mass="89444" checksum="FD2AF8179A52D936" modified="2019-01-16" version="1">MVLMEYLQRNALCSQNADPLKKMPLPASIPPSSYANDLYPTKAPKPAPQQPSSWPLFGTAARVLKGGADLVNSAAAHLRDGLSEEDRLRIQRTEERRQILSLRMKNAETADQWKAAARDLDDLEGNESWKHDPDSPDFDAVLVEARLKQLDKARTDCDTKAMLNLVRTSLSRDLAGMGNIKLYKHSYIGTKDLIERYIDSTIATIRALVETSKHSLPDGLETKDILEQVLYARQAFGRSALLLSGGATFGMNHVGVLKALFEAKLLPRIISGASAGSIVCAVLCTRTDEEIPDVLKSFPYGDLSVFEDSAREDGILERVHRLLTQGAWIDIKHLTRVMQELLGDMTFQEGYNRTRRILNICVSSASVYELPRLLNYVTSPNVMIWSAVAASCSVPFLFSAAQLLVKNPTTGENSPWNPTPQRWIDGSVDNDLPMTRLAEMFNVNHFIVSQVNPHVIPFLAKDDKAITRDAQSDSSTGPGWIYTLTNLAKDEALFRMQVLAELGIFPNLVTKARSVLSQKYSGDITILPEIEYKDFPRMLKNPTAEFMVQTCLSGERATWPKLSRIRNHCSVELELDAAVQQLRARVVFSPSQVDLRRMTTGSLRGTGKRIGRRRRESSSNVQALKKAIEAADNGSPANKIKAPKPLLRSSSTYQGVNRRQPQPLTSQTGPTTPIEGTSQLSQLFERPSPSKRNAFQLNLQIPDMSSAGETTQSPRSSDADIDSHTDESSPELDLSLNGTGLGIGDDDEVDFFSVNQPVTPRSDHVLATAPSASLSPVLSRSNLALHSERLKMSVPSGPESRYKKLFHRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SM50</accession>
    <name>A0A3D8SM50_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">nicotinate phosphoribosyltransferase</fullName>
            <ecNumber evidence="3">6.3.4.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_03091</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>5-phospho-alpha-D-ribose 1-diphosphate + nicotinate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:36163"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32544"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57502"/>
            <dbReference type="ChEBI" id="CHEBI:58017"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.21" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SM50"/>
    <dbReference type="OrthoDB" id="193380at2759"/>
    <dbReference type="UniPathway" id="UPA00253">
        <property type="reaction ID" value="UER00457"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004516">
        <property type="term" value="F:nicotinate phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034355">
        <property type="term" value="P:NAD+ biosynthetic process via the salvage pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.140.10">
        <property type="entry name" value="nicotinate phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041525">
        <property type="entry name" value="N/Namide_PRibTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040727">
        <property type="entry name" value="NAPRTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007229">
        <property type="entry name" value="Nic_PRibTrfase-Fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036068">
        <property type="entry name" value="Nicotinate_pribotase-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11098:SF1">
        <property type="entry name" value="NICOTINATE PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04095">
        <property type="entry name" value="NAPRTase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17767">
        <property type="entry name" value="NAPRTase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000484">
        <property type="entry name" value="NAPRT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51690">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54675">
        <property type="entry name" value="Nicotinate/Quinolinate PRTase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-0662">Pyridine nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nicotinate phosphoribosyltransferase N-terminal" evidence="9">
        <location>
            <begin position="17"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate/nicotinamide phosphoribosyltransferase" evidence="8">
        <location>
            <begin position="182"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Nicotinate/nicotinamide phosphoribosyltransferase" evidence="8">
        <location>
            <begin position="342"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF17767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW87397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="493" mass="54468" checksum="DA777501483DC8EE" modified="2019-01-16" version="1">MDFNGSSPFPEGVISFLDTDLYKLTMQCAVLKYFPDVLVTYAFKNRTPEKKLSRVAFRWLEAQIRKLGNIALSNDELRFLQNTCTYLNQPYLNFLKDFRLNPRDQIVATFIPENGTGADGDIGDVDLVIKGLWVDTILYEIPLLALTSEAYFRFMDTDWTYDGQEEKAYDKGMRLLKAGCIVSEFGTRRRRDYHTQALVFRGLVQAKKAGEKEGLPGQISGTSNVHLAMRFGIPPVGTVAHEWFMGVAAITGNYEKATETALSYWVGCFGEGVLGIALTDTFGTPIFLRAFNQPIPRITSAASGSAATIASTDSTVNSATDGLSTTELPLGAPLKSTESPVKTFAQVFAGVRQDSGDPANFVKLMRDFYDKHGITDKKTIVFSDSLNIELCLEYKRIAEEQGFQPTFGVGTFLTNDFVQKSTGKKSVPLNIVIKLSSAAGNSAVKISDNIGKNTGDQETVDKVKRELGYQEMDWKGGDETTRWGTEDDTVKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMD2</accession>
    <name>A0A3D8SMD2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_03126</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SMD2"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF4">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="155"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW87432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="338" mass="37413" checksum="332AAD1E552003A7" modified="2019-01-16" version="1">MAAASVYWQVSLADDYLVWASQSVPWKWNPAKLNQKSNGAAGFLHKISPGTGKSSTPSISQHSATTPQLSIEEKLTPEKFKPSPISTSLVTPEKQSNNGIISIFDTVFQHRLSPIERLAILTGSPVEAIFIPDSPPEITTTHENPPPSPPLFVTEHFEARASPKGGYGAFAIQNIAAGTGILSEPPLINCPDDGDGHFYQAYEGLSADDRKAFLKLASWSKIDDDRATAIWKTNRFRLDQTNSGLFLKAARFNHACLAQSSCCYQWDPASNQMHFTTTKDVAKGEEITISYATNPDLLYEDYGFFCDCKACPTLSSGEKFRRKCEVESKLRTELRRKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMY5</accession>
    <name>A0A3D8SMY5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_03238</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SMY5"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW87544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="171" mass="19345" checksum="4445ACD994CD7AC4" modified="2019-01-16" version="1">MPATPRSAHAPQYTTQHRYGIADDDCGQIAGRNPNCAGALVKRTSAIFGYGRSEPGGTGTSQRFPQKPTSFFVHMIDGPALPPYGRHENFMAIKDLDKVQDSWFAHEYAMPQFDQASHGRWYWKRFDPPKTLHVLVQPRDASSGDDVVVAITKRYQRQFYGSMHERRAAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SNC8</accession>
    <name>A0A3D8SNC8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_03494</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SNC8"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW87800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="182" mass="21247" checksum="3D253AD5F8093278" modified="2019-01-16" version="1">MEIDSWDLIHMRMLNGSISSWPEIYSKIYRHLKPGYGWMEHVEVDLMPRCDDGSLPSNSALMDWGRYLLDATTRAYKPLAYNTETRADLERQGFVEIQEQVIKVPLNPWPTDPHLKDIGRWYNLGLVQGLEAVSLGPLTRVFGWKKEDVDRLVAEAKKELCSRRYHTYCNMHIWIARRPAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SNM2</accession>
    <name>A0A3D8SNM2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SNM2"/>
    <dbReference type="OrthoDB" id="10017101at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050508">
        <property type="entry name" value="Methyltransf_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912:SF93">
        <property type="entry name" value="N6-ADENOSINE-METHYLTRANSFERASE TMT1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="39"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW87882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="284" mass="31135" checksum="BFFF78A8DD7F5C67" modified="2019-01-16" version="1">MAQHSQPSTYTQGYSNYTTASHQSRTAESDAAFLLPHIKKTDRILDVGCGPGTITTGLAKYASEGTTVGVDISPDVLQKAKDLATVAKVRTQGPGSVVFEEGNVLEKLAYPDDTFDIIFCSQLFGHLPPPDLPLQALAEMRRVLKPGGILATRDAASQHFYPRSLDLDRLWVQNQTRAFNEGRTDVDPTGTIMPALLRRAGFDTDGGKVRVGGGTTVYSGPEARKWLAWRATGQLQQGDTFRQSWLDAGITEDEIEQTLVAVGKWVEMEDAWYAALQCEMLAWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SP19</accession>
    <name>A0A3D8SP19_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_03232</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SP19"/>
    <dbReference type="OrthoDB" id="4356994at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="27"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW87538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="698" mass="79180" checksum="2F177A076A7EDE50" modified="2019-01-16" version="1">MEGASSLPLGISTSRAPSYQRRRAGNACLVCRSRKTKCDNQRPICGFCALTGGDCRYVDSSPSQFDRASLAILQRLGQLESTLIKHIDESSATLATIRGQRSITHKLFNQDGLSRNHQESRHTSTELHDESIFLSDETPSAPDIDWNEMPERSNMPPNGEMLLSSSDMSMDSVLRWPIFGRSVPHLQRMLETPTVERIGEHNNQMRSDNRERISRIGTTLLNLDSQVVNALVENFLAHNHIKNPILDVVSLQADVRGFAETGPQWDSKSCLILLVCAVSSLSAPLENELQPGPSKNADQLAVAEAYFQASQRRIGMLYHENTIVAAQCSFLTAVYLMSKLEILAAWKSFVQASSQCLGWMKSQGWQRDISILRDDNTEMGVAPGLERDRKRLHDRHIEESLYWSCLKSELEVRFELSLPGSGLCEMDYPHLFPDPPSDVPEDGTSPEDCEAVWSSPRTLNHSTDRQNLERAWYFYLAEIALKRMINNVIIRHHYQRQRNTQRPSAENDLEQNVLEFDMQVQKWYETLPSSMSFTQEAGAHTTDILRLILRSHLIDIRLSVRFPAIQKILSTEAPVSIDSVSATHLRIAREGLESAAACIESNRPSFYHRHQGSWLMLRSVTRCSLHILGVALNCNAVAESREHQQSLEDRILPQKWKSLLAEVRMMLEYWSDENNDVKALDRLFKELLSSYEKLSGLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SPB5</accession>
    <name>A0A3D8SPB5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">HAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_03332</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC61-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SPB5"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009651">
        <property type="term" value="P:response to salt stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000043">
        <property type="entry name" value="General stress response phosphoprotein phosphatase Psr1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="638"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="domain" description="FCP1 homology" evidence="11">
        <location>
            <begin position="389"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="199"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="550"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="221"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="557"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="594"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW87638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="666" mass="71507" checksum="4073DBAEDCAAE18F" modified="2019-01-16" version="1">MSNEIVQPTEQDPERSTSLEQSKALKTPTIDTSASADHNEPPSSSIKAPSTAPYTASTEGSETPVLSARQDENDLHLADEAPEVPKRNRSLLHVPSRSSSQKIQPSPTTTGLSGATASDPRDSIGGGSKESKVSILGKRRNDSASSSRMSITPTDPTADTTANSRSLAPQSAMAQKSKKKGFLSFLSCCGVPDHANVLDETALPANKVTKIPGRPTTASRPESKPIEHHSNDPTDVQTEKDTFRDESEKDAKVAKAEEVQSPVNGSAARSSIEARDQPLPQTPKQHESPSIPSYNALPVVVATSANSAEAQTDSPPTDVLQKDGDGDVKMQDSLPLETEKEESTAPSSTTSMPIVPTAPAPSNSAVDEVVAPDEAESKQQWLLPPITPRFQGKKCLVLDLDETLVHSSFKILHQADFTIPVEIEGQYHNVYVIKRPGVDQFMKRVGELYEVVVFTASVSKYGDPLLDQLDIHHVVHHRLFRESCYNHQGNYVKDLSQVGRDLRETIIIDNSPTSYIFHPQHAVPISSWFSDAHDNELLDLIPVLEDLAGSQVRDSSPRPSSPVNSPGAVSGSSTGRPSSPTPPGGPKTAIRRRAAADQKDKVANARPSSTRAAGAGGSTSTMLKLYTDESPGLKVDPVVVLVLSLVFIFSVVALHIIAKLTRKFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYE5</accession>
    <name>A0A3D8SYE5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Transcription elongation factor Spt6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_02481</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Histone H3-H4 chaperone that plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression. Essential for viability.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the SPT6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="995477at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09928">
        <property type="entry name" value="SH2_Cterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09918">
        <property type="entry name" value="SH2_Nterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.2740:FF:000002">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.650:FF:000004">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.850:FF:000001">
        <property type="entry name" value="Transcription elongation factor spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.140:FF:000007">
        <property type="entry name" value="Transcription elongation factor SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000056">
        <property type="entry name" value="Transcription elongation factor Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.505.10:FF:000065">
        <property type="entry name" value="Transcription elongation factor SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2740">
        <property type="entry name" value="Spt6, Death-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.850">
        <property type="entry name" value="Spt6, helix-hairpin-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="entry name" value="YqgF/RNase H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049540">
        <property type="entry name" value="Spt6-like_S1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028083">
        <property type="entry name" value="Spt6_acidic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042066">
        <property type="entry name" value="Spt6_death-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032706">
        <property type="entry name" value="Spt6_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028088">
        <property type="entry name" value="Spt6_HTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035420">
        <property type="entry name" value="Spt6_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035018">
        <property type="entry name" value="Spt6_SH2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035019">
        <property type="entry name" value="Spt6_SH2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028231">
        <property type="entry name" value="Spt6_YqgF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055179">
        <property type="entry name" value="Tex-like_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017072">
        <property type="entry name" value="TF_Spt6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145:SF6">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14635">
        <property type="entry name" value="HHH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14641">
        <property type="entry name" value="HTH_44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14633">
        <property type="entry name" value="SH2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14632">
        <property type="entry name" value="SPT6_acidic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21710">
        <property type="entry name" value="Spt6_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22706">
        <property type="entry name" value="Tex_central_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14639">
        <property type="entry name" value="YqgF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036947">
        <property type="entry name" value="Spt6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55550">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158832">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="13" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0727">SH2 domain</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="1112"/>
            <end position="1181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1198"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="94"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1210"/>
            <end position="1219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR036947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW91316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1419" mass="163128" checksum="1C113CD4278095E2" modified="2019-01-16" version="1">MSMRDLIQGEAELDDEENDDSFDEDTGEVRPTKKSQNGNGHLDDSSEEEDDDDDEEAAREVREGFIIDDDDDEEPDERERRRRRDKKRRRAEREEEEAALDEDDLDLIGETRPDWERKSAAQPKLKRLKRGHREEEDRVRERGLDEIFSDDEEVDGPGDAAERRFARPDHQRVDEFADFIEEDDLEDEDERQRHQEEMEVARPRERGYIGNGDTTGLDKDALDDMEAIFGNGEDYDWALALEDEAEGREQGDHALELKDVFEPSQLAERLLTDEDNQIRWADEPERFQLDRKPYKHVQITDEQFKEEARWITSLIWPKKQLDGDLQGPFTKAIGKVLEFFVVDEVEVPYVFQHRKDYLIHATKTRAQPDPNNPDAPEFNVSAKKLLNQDDLWRILELDLKFRALIDKRNVLEKTYDNLRASGIDEDKMFEAMLPAAVTMEELQDLQDYLYFQYAAQIKDLAAVNGDGKDLKRRPGGKSSLFDRVRRGRAYNFVRAYGITADQVAQNALREARKQYTEDHPERPIDFADSLTSNDDFQTGDAVLQAARATFAEELFMSPRMRKHFRMNYYMMGVVNCKRTEKGLRKIDEHHQYYEIKYLKNQTFGDLANKPEMFLKMLKAEEEGLLEVKVVLENERKFKERLYFEFASDNQSELADAWNDERQKVLDIAFGKLERVITKGVKESMRTECQDSILKLCREEYSKKLDQAPYKPKGMVLGTIPRVLALSNGNGDPGRDAVCWAWVEEDGRVLEHGKFDNLSRDNNARDAFVELVQRRKPDVLGVGGFSVETHKLISHLKDLVKDRELRGAEYEDQETGEDRSEPLDVVVVNDEVARLYKDSPRAALDHPALVPLTRYCVALAKYLQNPMKEYAALGKDVISLSFHPSQQLLPEDKLRRQLDTAMVDMVNLCGVDINEAIGDSYTANLLPYVCGLGPRKATSVIKAINANGGLVNTRDELVGDPDSGKLPVVGPRVWNNCASFLSIEYDSSTPTSDYLDNTRVHPEDYELGRKMAADALELDEEDVKAEVDEAGPGAIVRRLIKDDEQEKVNDLILEEYAEQLERNYNQRKRATLETIRAELQQPYEELRRSFALLSDEEIFTMLTGETSDSLCEGMIVSVNIRVVKEDFLIARLDSGIEGRVEATDGSDRGTELLNRLFSVGQTAQAKLLEMDRRNFTARLSLREEMLRIPYRKRVDREPGSWDALQEQQDSEELKEKDKTTGRTQRVVKHPLFRPFNSIQAEEYLGSQSIGDAVIRPSSKGNDHLAVTWKVADGVYQHLDVLELQKESEFSVGRQLRIGGKYTYTDLDELIVDHVKAMAKKVDEMMQHDKYQAGSKADTENWLTTYTEANTKRSVYAFCLDPKHPGYFNLCFKAGKLARVNTWPVRVVPNAFELMKAPYPDMKALCNGFKLRHASEMTRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYG0</accession>
    <name>A0A3D8SYG0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_02518</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin Nup133 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="103454at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000972">
        <property type="term" value="P:transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001057">
        <property type="entry name" value="Nuclear pore complex subunit Nup133, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007187">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014908">
        <property type="entry name" value="Nucleoporin_Nup133/Nup155_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037624">
        <property type="entry name" value="Nup133-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13405:SF11">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP133"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03177">
        <property type="entry name" value="Nucleoporin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08801">
        <property type="entry name" value="Nucleoporin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like N-terminal" evidence="11">
        <location>
            <begin position="110"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoporin Nup133/Nup155-like C-terminal" evidence="10">
        <location>
            <begin position="670"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1373"/>
            <end position="1394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1345"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="7"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW91353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1394" mass="156091" checksum="F29113BEC545F1AB" modified="2019-01-16" version="1">MFSPQLNGNAAANSTRSSRRRQRPHSNEGSIAQPKAKRQRSALSDHTFIAPNGEVAPEMEETKGKIASVVRQESAKDNAVHAPKREIVVRGKKAKTGERTNRGDGSVVLTTNDTYTVSKLPALPDRLRTDITARQHGAIYSDTGYALTLTHSHAMVWPYATSIPSPETFTFALPHPSKHTSDALPLGSLVSASASSPEPGLVVVMPTGIITYWESIATAATLDLIRQQRNGVEYNIPSMLHGETAVQVLNAESAGFVIGFSTGRLAYMSVRDREGRPAISVQFLRGASGSGAGGLFGSLRHALTMSAWRGDIAAVRAGRSDKIGERNVVVATEKGKLQAWNLHRDGHNSLRADADGREAIVLAIKHANPALSDLLLESFEVLDFTFTPKSITDSQLKDQGLEDDDKGVHLLLLTSLTDGDAAHYSLVEVVLTPEEMLIGTIRTIRSYSTPKSRIAACKPRLYLPKPALVAFVVFDRAVIVTSMAKQPDSPESQLRAESHLTTRSFEDVIDFREDLNVEIVGSGMEEPQPLSHDDSKSRKYKAKYPAVVMIVRGGGVVRVAATDVSKLVTNAPQVTPKSKLEQAVFFGTLDKNPLSFVGRMEQQFSAEEAGLAALELSRDILRSDTPYIPSVPASIEQNLKKRAAALRDLALHLKSTGVMRKLDRELRWRLIWDAEKMAAAVNIWKSYDTRLKTKPEGQKRGLLTEIIEFIHEDYKTEPLPEAGELDRVRLWFIKDVWNLEVAVPWAYQVIKYTYQDGQKDHAFIMETLSEANDVVLGALGGAFDFRTANLKLYELQSEKLKHGILLDDYEDLPEFWTSTFYITDNIRKQADLAGMLLREYWQSANNSQRPDESVIEKLRLESPTLIDLGIRSNLERIRWDSVQDEPQLQIQAEELKSLQDKSQHDQLTLLAEDIDLPNEAISLAEKHAILPTLAEVLMSQIVHALTYLKMPAIDKDEQEYWQRRASDLQTQAEKEFTKFGAGWATALYEYHISIGAMSELLDKYQNQQRFLTQFLRSRPEYAKVAWINEVSKEKDFEQAADTLLDLGMKREQHLWSKKVELSLGKLARLASKKTYSQSNGLLIPDGGQADFAGIHDQLALTNIQERIYKHVLPSISSAVDESAELQLALEAHGNKSLLKMRYFASILEEAMKYLLQHHVMTPGELFDLLTLMGDNGRGDEDDSIHGEEFYLALQAAHRGIQKKDDSYIAQQIIWRRCFLRDDWSKINNTDLKNDDEVSDQLRSTALYSTLRACFKNRLFDPSTNVKPLGPKDVLTASTTDLDGRFNGLDASIREFIMKDMQVESAALKPFIDTCRLEKWHQSALELAKLDFEQELSEETIDGTMMQDAAKKLEEVEKEIKELELKNASNLLHSKPNFKARPKQNGGFRASTKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYM7</accession>
    <name>A0A3D8SYM7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Outer mitochondrial membrane protein porin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_02577</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic mitochondrial porin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYM7"/>
    <dbReference type="OrthoDB" id="7827681at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046930">
        <property type="term" value="C:pore complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015288">
        <property type="term" value="F:porin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008308">
        <property type="term" value="F:voltage-gated monoatomic anion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07306">
        <property type="entry name" value="Porin3_VDAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.10:FF:000012">
        <property type="entry name" value="Voltage-dependent anion-selective channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001925">
        <property type="entry name" value="Porin_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743:SF70">
        <property type="entry name" value="GH26960P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11743">
        <property type="entry name" value="VOLTAGE-DEPENDENT ANION-SELECTIVE CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00185">
        <property type="entry name" value="EUKARYTPORIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-0626">Porin</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW91412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="326" mass="34986" checksum="FE005319F939A62D" modified="2019-01-16" version="1">MSVPAFADIAKSSNDLLNKDFYHLSAAALEVKSNTPNNVAFKVTGKSTHDSKTSGLLEAKYTDKPTGIYTFQKPPMLSCRSQFARSNLFDFFICMAPGYAELLMFYRRTGLTITQSWNTVNALETKLELNDAVAKGLKAELLASFLPTTQAKGAKFNLHFKQANFHGRAFFDLLKGPTANVDAVIGQDGFLAGASAGYDVQKAAITSYAAAIGYSAPQYTAAITAANNLSVFSASYYHKVNGQVEAGAKASWDSKSSSNVGLEVASKYRLDPVSFAKVKINDRGVAAVAYNVLLRPGVTLGLGASFDTQKLDQASHKIGTSFTFDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T013</accession>
    <name>A0A3D8T013_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_01264</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T013"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF40">
        <property type="entry name" value="THIAMINE PATHWAY TRANSPORTER THI73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW91870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="266" mass="29309" checksum="4FA536EEB532CAFF" modified="2019-01-16" version="1">MFLVCGLVTIALGVLVLVFLPDNPMKSKLPTSSKTRAIERLRENKTGVENKSFKIKQMWEALTDYRVIILCILFMLSSEVNGAMGNYQATLIKSFGYTSKQSALFSIPLGLLGLISIMIVTYIAGRFGQRLLVITCICPIAITGSAMTAYVPVRGAKLAGIFLLELVPITPLIYTVAVANINALILMSFAVGNIIGPLTFTGNTVPKYIPAKIAIMASFSCVMITALTLRTILLWENRRRDKCGLREHAANSDFMNMTDRKNDKFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T042</accession>
    <name>A0A3D8T042_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_01263</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. RimJ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T042"/>
    <dbReference type="OrthoDB" id="64477at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051531">
        <property type="entry name" value="N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792:SF8">
        <property type="entry name" value="[RIBOSOMAL PROTEIN US5]-ALANINE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792">
        <property type="entry name" value="GNAT FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00765)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="30"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW91869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="200" mass="22673" checksum="89069B929D947EBB" modified="2019-01-16" version="1">MTSTFYTHESNLFHPTIQHFQIHSTTIPELVLRNATPADGPILLRLFTDVKNVGLDESAAGLGTPEAISDLIRQWNTFEPLERVNAVIVYQGTVIGTGGIGWISTTWQGKRIGNVGVMIDTPYRGKGLAYEALRMSIDYAFRVLGMELVDCSTRDENKEFRGLMDRKFGFVGERIKDLRFGNDWTWTIERKAWEECSHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1G0</accession>
    <name>A0A3D8T1G0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L44-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_01806</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1G0"/>
    <dbReference type="OrthoDB" id="2967263at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.80:FF:000001">
        <property type="entry name" value="60S ribosomal protein L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_eL44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053708">
        <property type="entry name" value="Ribosomal_LSU_eL42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36A/L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01172">
        <property type="entry name" value="RIBOSOMAL_L44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW92412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="171" mass="20000" checksum="0AB0F96DB2C14512" modified="2019-01-16" version="1">MEGQISRRCWSDMKYLWPAISMASSSDSQTAQLQYMGNLWRKQQIFKWKRRNADIHLFTGQRPKDQTHLLQGRYRRVYNRDVGDIIQREYGLTFIFKASLFAQGKRRYDRKQSGYGGQTKPVFHKKAKTTKKVVLRLECTSCKTKAQLALKRCKHFELGGDKKTKGAALVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1G8</accession>
    <name>A0A3D8T1G8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA ligase/cyclic nucleotide phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_01807</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1G8"/>
    <dbReference type="OrthoDB" id="2967263at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW92413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="35999" checksum="2777050E7A0E6BDB" modified="2019-01-16" version="1">MASVPAGTPDVLNKFEDLSGVNSALYQNPYDALLEACHDDPVLIQARYDTHRTTRNAQQKAALLSPSFSGLNIDQILRKLEDQTIEPGFSDPRNCLVFWARPPKHIRDLVDRVQTKLRESAPGLWLMPISNLHLTALEVTHSLTSPEILALVEKLGDNVIKNMTDYPYQHRARLIKPMLSYDASAIALSFVPAASENLLGSRSPEDDTFSYHHLRRDLFNIATTESPVTINSRYVVPSSHITIGRFLTQEDHNSPEKMKRWIGAIEEINEMLFREFWPDDQAKDISMGEWIVGQEKGLDCREGVLWYGGGQTVRLGKGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T701</accession>
    <name>A0A3D8T701_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_00089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T701"/>
    <dbReference type="OrthoDB" id="5379885at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="564"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="564"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="599"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW94326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="635" mass="68972" checksum="11A7E032803C0F4D" modified="2019-01-16" version="1">MEGLMLVPPERGTIIGRALWKPRYIILGSALRLQTPPENALPRATSTGRVATARKGLKGPLSKPSLANISEPIPEGLFISIYKAKGDWEFIAQHPISSFASCEVQSLQHRKQSPSVPTLIINLKPDAELERQRKRRSSRTGGLTSSKDPWASTLLFRTVPEEQHNIYDWSMAIKSILDALAPREDVLSPISPVFNNFTNPFASRDGRPMSSSQRPDLNRGYSSQTTSTYSTAPRMEARGERPSAVLSPSPSLRSRRSDLSSQASSQPMGFSTSHSQHYTTALPSDLPSPASTSGYETQFIEGWTSAQGRSSALSSHTRGSNSIASAVASGAVIASTPPGPRETILDRAFKNRVIPGSDRLQEADEDHLSSIARFEALMREAEERRENRMGGSSHENARDAQGWDLDEESEESDYEYAEEENEMEELEVEQEDDLVIPTPAQRALDYISGRATPHSHSSSHGRPQSPAPRSPPIPFVNQQAMSAFHANDGTDGLRPRTGGGSRPNSLAAIAPRSMSTATVPTLKDGTFPLISENEKRGSSNSVKRLSFSEFTRRLSSTSSLLLVQTNNSSSSGSQQSKPGSSETSGGVENEDSTRHVPRNSVNPRGGSSQSATEQRDKRCGWRGSVGVFGNEGGFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T789</accession>
    <name>A0A3D8T789_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_00064</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T789"/>
    <dbReference type="OrthoDB" id="4874416at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017806380" description="Cyanovirin-N domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW94301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="15582" checksum="4FBFD34FA1A12174" modified="2019-01-16" version="1">MKFNTSLLAILIPAFTLADSIAFGDFELDGTTGLRYMWTEGKDPCQNARSGGNGFLLDCYNEGGLDLCNLNDNPCGHKFTLDNGKSYKLEGCGGSDFALYYYNSGTFISHATYATWNSDCGDSSGNYQVHKTWQFQCDKPGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7L9</accession>
    <name>A0A3D8T7L9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_00277</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7L9"/>
    <dbReference type="OrthoDB" id="3564464at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="958"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW94514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1015" mass="113771" checksum="966EC36A0323DA32" modified="2019-01-16" version="1">MKNRHTDASDSGGVQRNTKRQRRIGRTDGSLQVSEDGGDLLDIQLDSNSISVENSITRSLRASTKSPVISTTSTQVTTTNSTLVDKPVQKEFVPDHGKKYKCKYCAYSSNIKANRNRHQSTCRGIRQKHSRNKTFNSAECNYCGLLVPGDSLDKHLDTCIYNPDSDPITSLLLTYTSTTTLSTKQNYQDSSGYNDPIDLEFTTAWSPLSQPSLQETPQVSSNTNPTAISSSKAKNPSTFKFTLGQVSSASDIAVSAARPVVQEETPDSHFLVDPVIDNSDQDSSETCESDNASCRKEGQLSSNKARLQSNKSGEILNEAATASTRGLGHRTDGLKDRLSDMNIRRFMAQDMQNWSKRRLSIALTSRGLPSTGQKATLIARFFNPEYAQESYAASRSISIQLQEVKETYSISTMTRVIALHLVCTEEFHEAMGGTVIHPTTFVLQKNWICNIFVPGAALQFENADKWYQHVYSRKESIIRAAQKICHEIPAELKSKSMSSVQAPRPQSPQQISNPVRDNVFRYQEMRRRVLDTAKMCAEEQYNIRKETGLILLQKDSESQQKVLKGLYYLQEAESECNASLHDFSFETAVIGYIDRLISTKNWNETAYESTAALQAHIKSIHQQAITLIMKEHDFAPIYLPSSLRTTVFTRSTQRTSEVLEHVKAPEPLDLSLWSDSSMKDCSTRMVQALPLIFGAVDPQRFEFTMAFFLSISERLSSLSSTTPKCKPGCTPRRGRDTALLAARTIPFEDLLHDNVYHMKKLFEILQQESLLRSRTDMEKEECRQTSEKTWLRIIALVSLYYGCLAEPGSILTVIEKLLQDLGSCFIRDGLSTFASTTTMSSTGKITRIELAGGKIKYELPAENNRPCSELSWSHRQRLLLAEFGRFFRGSIITAYRITAYVIPIPSSKDNQWRSLVFDSLLYWTRDCGCRDCKLPLDFTAVEATNPPFMRIGTLMSVLVKYCVLAGATPLGLFIIILQRSSTWTAKHGGARSATFEASKLTTPKAVQVVPYFVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8U2</accession>
    <name>A0A3D8T8U2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_00752</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8U2"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW94989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="166" mass="17777" checksum="64529C4AA292ED8C" modified="2019-01-16" version="1">MDNSGKTALSKAAGAGRKDAVQLLLAQSGLQKSNVNAKDANGWTPLLWAAQLGFGDVVELSLTSPNIEVNTRDWDGRTALFWAAEKGQEAVVEQLPAHRSTNINVEERHGRTVLSYAAAAGHEAIVRLLLAHKDISVDVKDGHGKTALAWATGKGHDAVAELLRFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8V4</accession>
    <name>A0A3D8T8V4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_00634</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8V4"/>
    <dbReference type="OrthoDB" id="4150467at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="606"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="285"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="408"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="634"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="182"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="425"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="560"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW94871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="689" mass="73900" checksum="230EAA52972C2A4B" modified="2019-01-16" version="1">MVPPMSMRIAEERSETPPTAYSSGQSGSATPHNPSVSPFASPVPKSVAFELLFPESPQYRARLPMRVQIFPHDTTDSIITTVKNFYGLYGSSSGAKGVSFEDEHGHTLIARYENLRNNMVVYVRVIDEPAPSVGAYGPPSYHSASPVHQHTFYATEGHHMPPPQPAQALSYGHPISRPTSRASHKRSVSPNRGRRSASASTNLPPIKKNRSRSGFKSRGSSAHGSFAEIHSDGLTGYSSGDGAPGSVSSKTKSEHLGNTEISLDNIVEGGRRKRAKFESSELPLFAPPQMPAATSNSSVSPARRMEHQRGSFPFTNPSQHPFSNPHPLQSPQSYNNGFGQPGMYTTPASGARRTRGSGSYPVARHSLGSTPGNSSGILPTPDPTVGSTMSEEDKDVALQLMRLGDMSNISHGRTSASTFADDTFSGKADAASSTGATSDGESDSEDELPPPRRQKLEDSPILAPGSIKKFRPHLNDILPSQDSTEPSGDEYEDGRDGTFRPAGPDDPMEETDGAKSKVIKVKNAPSIMVKPRNNSTGTKSSKTKTAKSSRPIALVKSKKSGSTPTVKGPMSPSSLPSQSRKTSVASAINFQHQLAEDEEDLSSKPRCQRCRKSKKGCDRQRPCQRCKDAGLSADQCISEDEGNGRKGRYGRHMGVPVKKDDGPQPISTIPMSVMAGGQGSPDKSKKRKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8X3</accession>
    <name>A0A3D8T8X3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xaa-Pro dipeptidyl-peptidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_00654</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8X3"/>
    <dbReference type="OrthoDB" id="416441at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050585">
        <property type="entry name" value="Xaa-Pro_dipeptidyl-ppase/CocE"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00976">
        <property type="entry name" value="CocE_NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056:SF10">
        <property type="entry name" value="COCE_NOND FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43056">
        <property type="entry name" value="PEPTIDASE S9 PROLYL OLIGOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase C-terminal" evidence="2">
        <location>
            <begin position="318"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW94891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="625" mass="70528" checksum="9C6D3C5953ED437B" modified="2019-01-16" version="1">MPNQIRDLHKVDAESFPYVFEQNAAVQIKKSPGLVRVNVYRPKGDGKHPVLVTYGPYGKDIYYGDFHPGSFAELPPEQKSPHSAWETPDPGFWTRNGYAVVRADERGLGQSPGVLDVMSRETSEAFFDVVEWAADQSWSSGKVGLLGISYFAGSQWRVAAQQPKGLAAIVPWEGMSDYYRDRCRHGGIFSNEFIRFWWDRQIVSNQYGKGGRAAKKWGPDTIEGDLSEEELKANRQDQNIDNANNQFRDQQYYAGKEYNKEDIVVPLLSVANWGGILLHLRGNVEGYTHAGSEFKYLRFITGRHDLPFYQKEEVEIQKSFLDAFLKGDDQLGWSTPGKVPPVDIVLRKGDVGHNDAAAEKSYARRHESEWPIARTQYTPYYLTPDLSLTPKKPERISLSKVSYTATGFKADDGREIGAVSLGWKPLVDSFELDEQVSFTTAPAEVETEVTGHIVAHLNMSVTPTIPGITPSEIDLFVTLRHISAEGKEVFYTGTAGNPVPLCKGWLRTSLRKVNKEHQNHREWLPHRDYFSTDILPVVPGEVYPVDIELWPTNVVLDPGSKLVFEVSSGDTQGCERFKHTDPIDRSHEKLAGKNNIHFGPRYENYVTLPIIPAKPKQWRIFKDGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q4D2</accession>
    <name>A0A3D8Q4D2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_13129</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000026">
        <property type="protein sequence ID" value="RDW56488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q4D2"/>
    <dbReference type="OrthoDB" id="9930022at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08276">
        <property type="entry name" value="MDR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052711">
        <property type="entry name" value="Zinc_ADH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45033:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C1773.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="19"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW56488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="295" mass="32146" checksum="A9FC3D18194812B4" modified="2019-01-16" version="1">MDNIAVSVSRTWTLNNRMEELDKLKFNHTTISSVGHHEVLVRFHYASLNYRDVQMITGKNISNVKDNVVPGSDGTGIVIAIGSAVTRFKAGDKVLTVFANVFGSPTLDDFLNLPLGGAQDGTFRQYGVFNEERLVTMPSSLTFEEASCLTCAGVTAWNALYGLPCYSIKPGDGDTAKSLSPDGQGVDHVIEIGGPGTLEQSFKAVKLGGLISVIGYRGGTSGEEPGFVEVIRRNCILRGVLVGNRQHLEQMIRAIDANGIKPALDPKDWKLEELKEAYQYMLESKHLGKVTIRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q679</accession>
    <name>A0A3D8Q679_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dienelactone hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12776</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q679"/>
    <dbReference type="OrthoDB" id="2147163at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668:SF1">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G01940)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="37"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW57326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="249" mass="27793" checksum="71A49BE66C046EF9" modified="2019-01-16" version="1">MEPIPGYSRACCMIPPIVAKEYQEKGKYETIGGLKIYVTGSPTATKALLIGYDIWGFSSQVIQGADILATSDKDRSYQVFMPDFFKGEPCNKAWYPPETDEQKKNLYGWFATRTPALSAERTPQIIKDVEAVYGKKAWGAVGFCWGGKFVSLLSGPESLFNAAAQAHPGLMDPADAEKITIPTCVLPSTGESVEDMDKWENALKVEKYVKRFEQGHGWMSAKGDLEDEKCREDYGNGYRIFLAWFAKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q7B5</accession>
    <name>A0A3D8Q7B5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_12523</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C56 family. HSP31-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q7B5"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03147">
        <property type="entry name" value="GATase1_Ydr533c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF11">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="6">
        <location>
            <begin position="31"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW57722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="239" mass="25720" checksum="32D514E00E5E1C24" modified="2019-01-16" version="1">MTPPRRALISITSAHASLFQGKETTGLFISEALHPYKVLTAAGFEVDLASETGSYTADWLSQQPDFLNGADLAIWNDTNSNFRKKLDNMAKAADVDGSKYGVFYASAGHASLIDYPTATGLQKIATQVWANGGIVSSVCHGPAIFANIIDPATNEPLIKGKKITGFTTEAEHSMGIYEELRSWDSEMVEELAARLGATYERSAGVWDDFHVVDGRLITGQNPQSAASTAQAVVQAFDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q7E7</accession>
    <name>A0A3D8Q7E7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q7E7"/>
    <dbReference type="OrthoDB" id="3029913at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW57765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="808" mass="90091" checksum="2D9B1A59FF2FC946" modified="2019-01-16" version="1">MSFATLKTARHPAIQTSANPSSGDGAATIGSTRWKTSILYKLEKRRSTRTWSQLSKVARILCRRSKRSKSMAKKVPWMALIAFTEDELRLDPKYLEGDAAISRNFTTEPNKPVPRIEQDANLAVQLPLNQLLNLADCQTPVKVAGHDTSKETSLSAIFLKPSLFNELFRNQSINDGDQRFPDLSRHGYLSHVRQINTEGMAEAGVEKFAHHSIVLSHRTGPVNQKTKTPVVVHLVSLEGIENMEWPIPDSAQFVAMSSLSSWTYMCHPPGTFDVERMIRDLGTTRGPLRGTLPSSSTIDARVDPSSQGQRLAKRFSDGYTLTRHRTKIGEITTALVRGALTPTFVTRPILEDLSKMSDYGTDLEIWDHEAGLVDITYSLAWQLGRTLAMADGGFSIALMKLRSQIYVEAMKQAKGNISMGRDVCVPKDEAMNATANIMEALDKLQGDGPNTEIGQRRLMDRWKMDRWNGEVKDPVGSSPNRKLNTRYTGARKMAEEFKTSADPDSDDIYNELDQPTSSEWQLVLSWTLDKMFLSGIPSQYLVVDPGYLPPESLRFFHIDPNWIDAFLDGALSLGNHLTTRIDKVRLTIKRLINDYITTPLPTTNHPPPIPLYGFLIRSDVVTHFPDLRVTAESEPPKADPNAPPTLRQVLLADGVLMCLVDTSPLSNGPSRLTGLRFTLPPHQLSFEIGTHLDGQSLSTRYKKTYTGSDGSNHSDALCPDYKLTLDESLKDKGSSIFAWGANNEIRSLQFPAWLNKLLENSESNMHGKDENFTCKVMTSALVGMQLTKPPVETFISVDEESRVPYKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q9E7</accession>
    <name>A0A3D8Q9E7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q9E7"/>
    <dbReference type="OrthoDB" id="294702at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="67"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW58446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="340" mass="37245" checksum="EB76F2B8B4548365" modified="2019-01-16" version="1">MASAIDWSEGERSGLVSIGTHNLRLNSYGPDRKPGEPVVICIPGLASSIHKHFAILVEATPASTLAFNATAWAAVTRLLKPHIRSYTYDRSGFGGSDLSPLPPTATNIAQELSLLLQRAPIAPPYIFVAHSWGGILIREFLHLQPDPASIASLVLLDSNHDHMAKLIDWRTPALWSMGANVDFTALSAFSEPHGLTPTEWDIYQADLASAKHNAQADKEREQYSPSFPAIEAKGQLQRGEEEGPLLGDSPISILVAPQHIGFQQIYDAGLAKGNGTEEERATVSKMLATWKETHERLQGELTALSRRTRVRPVSCQHDIHLLDPEAVVEEVLWVLNEGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q9F8</accession>
    <name>A0A3D8Q9F8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRISE-like Rossmann-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q9F8"/>
    <dbReference type="OrthoDB" id="1731983at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08948">
        <property type="entry name" value="5beta-POR_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055222">
        <property type="entry name" value="PRISE-like_Rossmann-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32487:SF0">
        <property type="entry name" value="3-OXO-DELTA(4,5)-STEROID 5-BETA-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22917">
        <property type="entry name" value="PRISE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRISE-like Rossmann-fold" evidence="1">
        <location>
            <begin position="5"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW58411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="350" mass="39879" checksum="E4351649E58E1956" modified="2019-01-16" version="1">MSRVALITGGNGITGSAILEHLVNNTTAKEWSRIIVTSRSPFQTTVCDDRISFIPLDFSEPSNIVAQKMRSECSSVTHAYFSSYIHKDEFTELNRANEALFENFLDALIAVAPNLENCTLQTGGKYYNVHLGPVPSPAREDLPRIESPIGNFYFQQEDHLFKRQKDQKWTWNVNRPEAIIGYTSKPNGMNSALTFALYFMVCKELGAEASMPTNQTYFNGYDAVSDSRLIADLTIYASTHEKFSSTQVFAKESPVEGILQLEFRLAEWVKDKREVWDRICDKAGMPTAKATWDAGTWAFQDRVFQRTWYATLSISKARKFGWTGYVDSYDSFRHAFEKLKELKQILNVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q9J6</accession>
    <name>A0A3D8Q9J6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12445</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q9J6"/>
    <dbReference type="OrthoDB" id="10439403at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW58515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="195" mass="21459" checksum="6E63482F67D31A42" modified="2019-01-16" version="1">MKDINSPDVSEVLPQATTYWSKVSKRVSSFIVGPRSMYASSISGVDNPFEYSNYLSQKKPNKKNSSPDDDMECEETKVVILRKPVQTKKDEKGSFTKEEERSLPRASTATFGQNDIDNDTKCPPAEFESSVSTLSKKGIESQERTMRNTRSSLELHTVVGSSPNLSGLAGTKSGKVRPKSEVTPVPALNKSRGSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QBG3</accession>
    <name>A0A3D8QBG3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_11971</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QBG3"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017555082" description="Tyrosinase copper-binding domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="270"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW59047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="357" mass="39337" checksum="C5C295C179B7F966" modified="2019-01-16" version="1">MHLLPTLSVAVAALAQLTSAAPTTSGSPALVRREWRSLTKAQQLEYLSAVKCMQKTAPRTKALYSGVQNRYDDFVALHINMTDQIHFVGQFLPYHRGLLALFEADLRNTCGYKSAVPYWDWRLDSTSVDAFAQSPIFDATYGFGGNGQYLTDAEKALLVDTAALTIPNTTGGGCVTTGPFASLNASMGPGSSTDYTPHCLRRDLSGDFATQSLNSTVVDIILSTPDFLLLDRRFQSLELDLAGVWIHGGGHFSVGGNTGDMSDMWSSPSDPLFWSHHAMLDNVWNQWQRLNWTVRKAEITGPDTMWAYPYNYFGDIPYKNITLAFDLAYGQLGETVNISQVMDTTDMPCGLNSYTYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QBJ6</accession>
    <name>A0A3D8QBJ6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">AAT family amino acid transporter-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_12140</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QBJ6"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF37">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="406"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="7">
        <location>
            <begin position="57"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW59216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="556" mass="61548" checksum="8D0769B9C0E90F1F" modified="2019-01-16" version="1">MEPMMVDAKSSEKFSVNEGNSEEMPSVECEQVLEYPTEKLAHNNNSTKLHRTFKARHIQMIGLGGCIGSGIFLSTGKALYYGNWTAMFIAWIVVCTMSTATMQVMSEACVIFPTSGAFIDHAARFVDPALGFAVGFCEWLGWTTTMAAEGAVFRTILSFWTEEVPTAACMTIYLVVIFSIHLLPNRVFAEFEFVTAAIKVVMMVIIIIVCIAILCGAGPTGSTNWGTNFTELPAFPNGFKGVAQAFLLASWSAGGLEFIGISNGEAKMPRWNLPRAVTNLVIRIFIFYMSSITFITLLVPYNDPRLFGAFSGEISASPFVIAMQDAGIKGLPSMINAITMLGLCAIGSEGVYLASRMSTAMARMGLFPQILGRVDKQGRPYVSICASAVLAIIFTYINIANTGAVIFTWFSAISSTMSFITYIVICITNWRMRKAFKLQNDNPLSLQYAYKNKFYPMSSVFLFVTSIFILCSTFYVSLFPIGKPTTAANFFETFICVPLFVVLYLGYKIIFKTKIVDLRTVNIQSGRRPLSAEDIAFLDAYYAKPWYKRALTYITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QBQ6</accession>
    <name>A0A3D8QBQ6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_12085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QBQ6"/>
    <dbReference type="OrthoDB" id="78947at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045108">
        <property type="entry name" value="TXNDC17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010357">
        <property type="entry name" value="TXNDC17_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452">
        <property type="entry name" value="42-9-9 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06110">
        <property type="entry name" value="TXD17-like_Trx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="20"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW59161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="129" mass="14348" checksum="35DA3B71FAD5D165" modified="2019-01-16" version="1">MPIVTDFTIAASAKQLVLPDEPDARFFIAFLSSTDPTTLQSWCPDVRAALPHIHAAFSASNTPDLAIVEVGQRPEWRTPGNFVRVNWNVHNVPTLVRFQRVGGEIAETGRLVEDEILDKKKLKSLVTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QBS6</accession>
    <name>A0A3D8QBS6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12153</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QBS6"/>
    <dbReference type="OrthoDB" id="9977941at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052998">
        <property type="entry name" value="Hetero-Diels-Alderase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060:SF1">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42060">
        <property type="entry name" value="NHL REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017816171" description="SMP-30/Gluconolactonase/LRE-like region domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW59229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="37171" checksum="DAFA2659482F4D2A" modified="2019-01-16" version="1">MTSFTWRGFLCLISLTSSLIQASHQSLPLPVREIYQFSIPTYIEGVYVRSNGDLIVTTVWPNASIYAVCGATTNTPTISLIHAFDEINAVTAILETQPDVFHFIGGNQSTLGFGIHGTYGVWELDLRPANGTNYIEPTIQELVRITDGGFLVALEIVPDTPTTLLVSDSTIGVVWRVDTLARNYELGIQDANMAYPPWGATPFGIDDIHIKNGYLYWSNSYEATVYRIAITDNGYPPAGAVSEVFKAVRALFLDKFSFGPDDGDTIWVAANANSQLVAITSDGDATFVAGVSDQMTLAGPIATAFGKLKGDTNTVYVTTGGGLVSPINGTIIEGGKIVAIDTTGFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QBW2</accession>
    <name>A0A3D8QBW2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_12183</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QBW2"/>
    <dbReference type="OrthoDB" id="425354at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012674">
        <property type="entry name" value="Calycin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053037">
        <property type="entry name" value="Pericyclase_pydY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115:SF1">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50814">
        <property type="entry name" value="Lipocalins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW59259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="188" mass="21217" checksum="4C99C3201E72D739" modified="2019-01-16" version="1">MAAPASITLKSLDGQWAMNRKLSGDYDPVLKLQGVNWLMRKVLSMASVTVTIKEWEEGGLTHIHVENRPASGLPPTTEDRIFDYKGIELAHPLFGKVRSQTRWAGAADLDEVDEFLAKGFETEASKTLFVHIMTEHLDHGVVTHQAWGFEEVEGERFQTRHIVVKKGDEVLRMMLAYDYLGPRPADEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QEQ1</accession>
    <name>A0A3D8QEQ1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_11905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QEQ1"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF102">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW60299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="41524" checksum="C741014B583EC06D" modified="2019-01-16" version="1">MAFASSEDNKPALTPPDRIQHPISGDKEIKEHPLPMCFTSLSATDLEVDFDLSETNNSDSDSAIETSDDVLTISAQSRHCDGLEQNARTYHRFKEGKYHLPNDEVEKNRLDLQHHLCCLAFESHYLAPIENLNVGLHNVLDFATGTGIWATEFAAQFPDVVVVGTDLSPIQPEHVPANCHFEVEDAEDTWNFAEKFDYIHGRMLVTCFQSHLKVFGSAFDSLRSGGYIELQDVSFPFLGADDRWNGSAFQHWMKLLMDGSKALGKDWNRVPRYKGYLEELGFVDVVERRFNCPLGTWAKGKKNKILGTWGRENILSGLGALSMVVLTKGLGMTAAEIELLLVDVRNDINKDGEQSIHLYAPMFVVYGRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QER4</accession>
    <name>A0A3D8QER4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Tricarboxylate transport protein-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_11921</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QER4"/>
    <dbReference type="OrthoDB" id="44467at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071913">
        <property type="term" value="F:citrate secondary active transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006843">
        <property type="term" value="P:mitochondrial citrate transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049563">
        <property type="entry name" value="TXTP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788">
        <property type="entry name" value="SUCCINATE/FUMARATE MITOCHONDRIAL TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45788:SF3">
        <property type="entry name" value="TRICARBOXYLATE TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="12"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="109"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="205"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW60315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="32081" checksum="BA7EA6CFE91A814E" modified="2019-01-16" version="1">MTPTNGKGDALVPPLVSIFSGGIAGGVEAAVTYPFEFAKTRVQLRQEKGERPPRNPFKIVGQVYRQEGFGALYKGCGALVTGSVAKDAIRFVSFDSVKNAFKDPETGTLTYGRSMLAGMAAGVLASGTAVTPTERIKTALIDDARHDKRYKSAVHCVRTILKEDGPVGLYRGFAGTTLKQASATSFRMGSYNILKDFEQLRDIEQTTVVNFANGAVAGTITTLATQPFDTIKTRSQSAKVTTTMEAIIGIWKDDGIRGFWRGTIMRLGRTVLAGGVLFTTAEAVARIITPLYDKAPAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QID0</accession>
    <name>A0A3D8QID0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Aflatoxin biosynthesis ketoreductase nor-1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_11389</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QID0"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW61497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="249" mass="26363" checksum="01497130C5688030" modified="2019-01-16" version="1">MSSPKIYLITGANRGLGRGLVEALAQRPNVTIVAGVRDLENASSKSLSTLSVGAGSKIINVKIDSKDPSTVKTAVSSLSSEHNISHLDIVIANAGISKYYGAAAQTPISEVNEHFEVNAVATLVLFQETWPLLQKAEKPMFVAMSTGIASIGDMGSLPLPATAYGMSKAALNYMVRKIHFENPGLNAWVMSPGWVQTDQGNAGAAAVGMDAAPVTLEQSVTGMLDKIDNATREETSGTFQSFDETKYAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QL97</accession>
    <name>A0A3D8QL97_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_10790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QL97"/>
    <dbReference type="OrthoDB" id="542013at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF152">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW62488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="320" mass="35690" checksum="F9E2D1CED0E93371" modified="2019-01-16" version="1">MSFTHTVLITGGTTGLGFQCALAIAREHPEFLIVITARTDSNSAAATINKTLRQKNVVFLPIDLSNLTTVRSFVTDWETKKYPSICTLVLNAGLQFPEGLRKTVDGIEATFGINHVGNTLLFYLLLPHLVNNVRVVVTSSGTHDPAQKSGLPDAKYTTAEELAYPAPEAAQIDGRQRYTTSKLCNVLWAYALHRRFKSVEGRSMTVNAFDPGLMPGTGLAREYSAPMRWIWTSLMPRIIPLMRALFHPNVHTPRESGESLAWLAASPDIEGASGEYYEGRKKVKSSVDSYNERYQEDLWEWTIKFTAKSPEEISRFEKAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQD2</accession>
    <name>A0A3D8QQD2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">CAP-Gly domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_10504</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQD2"/>
    <dbReference type="OrthoDB" id="2130750at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032108">
        <property type="entry name" value="CLIP1_ZNF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16641">
        <property type="entry name" value="CLIP1_ZNF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CAP-Gly" evidence="8">
        <location>
            <begin position="121"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="172"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="569"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="676"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="764"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="612"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="175"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="676"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW64002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="837" mass="90948" checksum="2916A42A1797B532" modified="2019-01-16" version="1">MAMTGLTPRRSLARPRPSASNPNLSASFYANGNKTLLSPTRPGSSVKVSVSRKQSLSNLTPNSLATIPDASKGYALRSVLDDDSPIAHKMASYSVNAADDYEVGDIVDVPGNMHGMVKFIGAIPGKKGVFAGVELSQEFAAKGKNSGDVDGVSYFSTTVYGAGIFLPVNRASRRGSPSSHEGSFPMTPTTPGFRAVSSAANTPPTPSLPKFSQSVGPGRVPSPQQKKQQAQRPSLQRPESPYRRQQLSTRPSVGALPKTPARYGSPGPAKFGQSVRGTQDSRDPSKKAALTPRNGLKSSVGPRSASALGSAPMNISDDELTPLGGARGFSKDHDSLGSLSSFNSKMRPASRANDDEIERLRNQLDEKNRQLKDQASSLAEMENSLNEVQALMNEDGISRPQRGSIEDKDLPQLRALVREKNEKIAMLTAEFDAHRADFRSTIDTLELASTETERVYERRVEDLLAEVRELQDRNEDVDSVARQLRQLEELVQELEEGLEDARRGEAEARGEVEFLRGEVERTRAELRREREKAAVSMVTNGSNAEASQALKDLEQRDDEIRGLKAIIHSLSRDAKPENGSPPDPQRTPTQRQGSFTAMLHPSQGLEPDRLSKEKLEKEITDLRANLEIKFQREEELEREVENLRRTSAAVPVSSQRASATTVGSGGTLIQDTVSARDSRVTTGSWKDREQNPSEQHRRANTLETMPESDTSTTESVVFCEICESPGHDILSCTNMFGAQSGANGNGNLTPNKQKTGKDAVLKGLSPRPSQDNYMPALSSPPKDKALPAPPPVKIIPNPMEQGPVAGKESGIIDPAKWCGVCERDGHDSIDCPFEDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QTZ3</accession>
    <name>A0A3D8QTZ3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">WAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_09937</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QTZ3"/>
    <dbReference type="OrthoDB" id="332390at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018501">
        <property type="entry name" value="DDT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028941">
        <property type="entry name" value="WHIM2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013136">
        <property type="entry name" value="WSTF_Acf1_Cbp146"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32075">
        <property type="entry name" value="ISWI CHROMATIN-REMODELING COMPLEX SUBUNIT YPL216W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32075:SF6">
        <property type="entry name" value="ISWI CHROMATIN-REMODELING COMPLEX SUBUNIT YPL216W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02791">
        <property type="entry name" value="DDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10537">
        <property type="entry name" value="WAC_Acf1_DNA_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15613">
        <property type="entry name" value="WSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51136">
        <property type="entry name" value="WAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WAC" evidence="5">
        <location>
            <begin position="22"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="233"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="331"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="513"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="710"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="975"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1017"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="280"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="299"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="346"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="515"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="556"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="743"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="763"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="975"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1050"/>
            <end position="1059"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW65245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1059" mass="121580" checksum="7DEC76963908C215" modified="2019-01-16" version="1">MVLFKRKPVQYVNRPVIDNDDAEVWVIEKTGEIFVEYEAYLSRMDFYKQRRFICQITGHSGLTFFDALKSELEGAQEVESSFPEALKGPILRRVQFQTISRIDTLVDLVYEEFRSDYYPGESVTVHVVTGERLTGIVRDKTRFGAKILPNGDYSKPFSRYFVSLDNRPSEEAVVDDSHISRDRKIFTKQVLRSFIKKTVTREAWTGAPWLVKHDVAVMYHIDTRVPPHLRYESKAAERKQQQAQKKSGPDYEGMVGSFPGQGAAPLPTLKPAPKSHKSKQQQIKLAQSKQQSSLYPAPDMHPNPPLHYFPPSSQYQNHPQFVSHTFQANPFQGHQVNPFQANGGHLPPPPPPRGHHPLPPGQQYVHTQDMHYGYPPMQPQQLPPAPPPPPPIKYPIEDLQVPQKSNPAVRPAIKFFSQDTPSMSEEEASKITEGNGILMKSVGPLLECWNTFNVYCEILKIDSFTFDDFVEAMQFSSEEVDCELFVEAHCAALKLLVSAEADGGKLQITLPEMASESDDEDSDDDSSPPTPTPEPEPKPKGRATRSSLAKAEAEALRQQQAEAEAAAQEPEIKHRAEEMQAEQIWTEKLAKRDFKNGGWQSIMVGFLYQLSKKESFEKSCTELLEKLAPLNMPPTAETARIQYGKLDVNFRVQALELVCLFMPQTKAIRGYMEECSEQMTGFRKEKIKWQRERKEHLEALRLLNEERKIQLPDNMPPSPVREPAVPTTNGDTAMADASPEIKESEDEVMDTDDDPHVGRSLRRANDRAAERQRKREAEEVKKAKAEAAAKLPKQTKQFTKLLKDIAKKEDEVKACEQEIAVLDNDLREADCPRTRYLGKDRFWNRYYWFERNGMPYAGLPDSSTAEAEYANGRLWVQGPDEMERLGYIDLEGDWLNEYRMKFDMTPRQRKEMEEGSTNVFHARQWGFYDMPEDVDKLIAWLDPRGFNEVKFKKEIMNYRDRIVERMEKRNEYLKKADDEAPETGKRMSTRTKHQQEVMPYRCLQWHNTMAVHELGHLHSEQPRARKPAKKAKIPTPEIEERETRSESKTKKQKIGKGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUL8</accession>
    <name>A0A3D8QUL8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_10235</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the calmodulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUL8"/>
    <dbReference type="SMR" id="A0A3D8QUL8"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000257">
        <property type="entry name" value="Calmodulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000027">
        <property type="entry name" value="Calmodulin (CaM)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000100">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00036">
        <property type="entry name" value="EF-hand_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="45"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW65543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="113" mass="13047" checksum="03DE1E9629B065B5" modified="2019-01-16" version="1">MRSLGQNPSESELQDMINEVDADNNGTIDFPEFLTMMARKMKDTDSEEEIREAFKVFDRDNNGFISAAELRHVMTSIGEKLTDDEVDEMIREADQDGDGRIDYNEFVQLMMQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QV81</accession>
    <name>A0A3D8QV81_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_10262</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QV81"/>
    <dbReference type="OrthoDB" id="203381at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW65570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="123" mass="13839" checksum="72EBBEC648017D9E" modified="2019-01-16" version="1">MRLLTRRAPTSLPIRRTLTTTRYPSLTIYRPLIAQRSPSILLSTAQRRHESSSTIQGTIGKGEAGVGDEVARSQDALKAPEHLNAKEREIFDQLARELDPVELDVRRPSFLTPGGWPEAFFTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QV93</accession>
    <name>A0A3D8QV93_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">54S ribosomal protein L12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_10116</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bacterial ribosomal protein bL12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QV93"/>
    <dbReference type="OrthoDB" id="250175at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00387">
        <property type="entry name" value="Ribosomal_L7_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.10:FF:000001">
        <property type="entry name" value="50S ribosomal protein L7/L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.710">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000206">
        <property type="entry name" value="Ribosomal_bL12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013823">
        <property type="entry name" value="Ribosomal_bL12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014719">
        <property type="entry name" value="Ribosomal_bL12_C/ClpS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008932">
        <property type="entry name" value="Ribosomal_bL12_oligo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036235">
        <property type="entry name" value="Ribosomal_bL12_oligo_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45987:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN BL12M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00542">
        <property type="entry name" value="Ribosomal_L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16320">
        <property type="entry name" value="Ribosomal_L12_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54736">
        <property type="entry name" value="ClpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48300">
        <property type="entry name" value="Ribosomal protein L7/12, oligomerisation (N-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein bL12 oligomerization" evidence="6">
        <location>
            <begin position="52"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein bL12 C-terminal" evidence="5">
        <location>
            <begin position="112"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="24"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="31"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW65424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="179" mass="19162" checksum="7ADDE0BD882B56DA" modified="2019-01-16" version="1">MSLTCQSAARGCMRSIRSSSSLRISTASLAQRRNPTSTSRRWASTESTKVAGIVDQISQLTLLETADLVASLKTRLNIPDMPMGGFAAGPAAPAAPVEEEEAAPAQQEKTLFNLKLQSFEATAKPKIIKEIKSMLGLSLVDSKKFVESAPKMMKEAVPKEEAEKIVAALKELGGVVVME</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QVE7</accession>
    <name>A0A3D8QVE7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_10176</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QVE7"/>
    <dbReference type="OrthoDB" id="5511599at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039297">
        <property type="entry name" value="COX7a"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02238">
        <property type="entry name" value="COX7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW65484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="76" mass="9159" checksum="88B8D7B3D55436B8" modified="2019-01-16" version="1">MLICMFNSFINRENRVPHYQRLFQQGQAQHVRQWNQTAKSKIMLYPYYTMLFGGLAGSMYMMTRMVLGHKTWFSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QY85</accession>
    <name>A0A3D8QY85_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="7">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_09532</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="7"/>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QY85"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08598">
        <property type="entry name" value="PI-PLC1c_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.190:FF:000039">
        <property type="entry name" value="Phosphoinositide phospholipase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF169">
        <property type="entry name" value="PHOSPHOINOSITIDE PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="PI-PLC Y-box" evidence="9">
        <location>
            <begin position="318"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="16"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="276"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00059664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW66783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="591" mass="65491" checksum="0F500746C565950F" modified="2019-01-16" version="1">MSEAAESLTSRLAGLNPFSKGVKHEDANDDKGEEITANTVAGGGHGARESGITKNQLRVSHALKSFLVENNVMSKGDAGLSDGDETTPALRDLLDKPHINVPSYLTDRSYPLPEYFISSSHNTYLMAHQLFGESSIEAYKIVLGAGARCVEIDAWDNDEDVDEPKVTHGYTLVSHISFRSVCEVMRDAFDKEVAEAVPEQGSRAAPILLSLENHCSPSGQLRLVQIMKEVWGDRLLSKAVREEGHREEQDTGDHVTLEELGAKIGVIVEHHIPGIVEDDEDDSDHDEFEDETEEQRKAKKAYKEKKKAAPVTIIIPELAALGVYAQSVKPSDNSWYEQQALTNGPDHHLINISESKLLAVMPGASTKIARHNAQHLMRVFPKGTRISSANLDPVRFWGVGAHICALNWQTFGASMQINEALFSGSDGYVLKPEALRAGGSGQLSDGRKKSLRLHIAGATEVPCPENLDADEIKPYVTCMLVHPDDLEKALPKRKTAPYHQHRLGFLHKYDNPPPTDPIWDETLEWEFEDNEMAFLRILIKSDESFATNPVLCVTAVRIMYITSGWSFIRMLDLKGRETKCSLLVKFDVVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QY93</accession>
    <name>A0A3D8QY93_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">glucan endo-1,3-beta-D-glucosidase</fullName>
            <ecNumber evidence="5">3.2.1.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Endo-1,3-beta-glucanase btgC</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="18">Laminarinase btgC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BP5796_09515</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Glucanases play a role in cell expansion during growth, in cell-cell fusion during mating, and in spore release during sporulation. This enzyme may be involved in beta-glucan degradation. Active on laminarin and lichenan.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of (1-&gt;3)-beta-D-glucosidic linkages in (1-&gt;3)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.39"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Cell wall</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 20">Belongs to the glycosyl hydrolase 17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.39" evidence="5"/>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QY93"/>
    <dbReference type="OrthoDB" id="68336at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042973">
        <property type="term" value="F:glucan endo-1,3-beta-D-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000151">
        <property type="entry name" value="Glucan endo-1,3-beta-glucosidase btgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050732">
        <property type="entry name" value="Beta-glucan_modifiers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000490">
        <property type="entry name" value="Glyco_hydro_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631">
        <property type="entry name" value="GLUCAN 1,3-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16631:SF17">
        <property type="entry name" value="GLUCAN ENDO-1,3-BETA-GLUCOSIDASE BTGC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00332">
        <property type="entry name" value="Glyco_hydro_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0134">Cell wall</keyword>
    <keyword evidence="15" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="307"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="21">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="153"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="21">
        <location>
            <begin position="209"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="21">
        <location>
            <begin position="334"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00037649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00042373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00043078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU004335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="RDW66766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="682" mass="73015" checksum="E653404AFE4E7FBB" modified="2019-01-16" version="1">MPRRYSFESELQPYQPPTVPSASPPLPPSYHSPPHSPLHHAAYSDVQRPEYEHLNTKSSPPPPPPHRNLSSRPQHSRDPKSMSTDRYSDRVKAGGMSGLAMGAADNFAREGGPEGSTNTTPPQQHDPRAGYSSYDESPYARPTYRQDYSQSSLTPLGAAALPPGQATPSLNSSVSRSNTSLQDSYPDGHVYYNRHSRAMTPNMEFDPNSIEDDGDDGLEYNQQRNQRHSMLNLNSGSGAAAGGAAAGGIMGTLGGLVGRNASGGNVPQYDPVGPSTTAYTGANDHGLDRREKNQWLKEERTAHKKKGVIVGVVAFLVILIAIVGGLAGGLLSRNSGSGSSKSGGQSASTDTTTNGDLSKDSAEIQKLLGNSNLHKVFPGIDYTPMNTQYPDCLTNPPSQNNVTRDLAVLSQLTNTIRLYGTDCNQTEMLLHSIDRLGLNGTVKVWLGVWQDSNATTNARQLKQMYSIFDTYGAASFLGVIVGNEVLYREDMTASELGTVITNVRSNLTSRGLSSLAIASSDLGDNWSTATSLVALVDYVMANIHPFFAGVNASAASAWTVNFFDTHDVNLKSDKSKAIISETGWPSAGGTDCGTTTVTDCPDAAVAGISEMNTFMDTFVCDALTNGTNYFWFEAFDEPWKVVYNTAGKAWEDKWGLMDVNRNLKTGVVIPDCGGKTVGAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYC4</accession>
    <name>A0A3D8QYC4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Autophagy-related protein 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Autophagy-related E2-like conjugation enzyme ATG3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_09545</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYC4"/>
    <dbReference type="OrthoDB" id="1584384at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044804">
        <property type="term" value="P:nucleophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="85"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW66796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="362" mass="40249" checksum="85CC581140256362" modified="2019-01-16" version="1">MNFLHSTLDKVREWAPVSHTSTFRANGQITPEEFVAAGDYLVYKFPTWSWADAEPAAKRVSYLPAGKQFLVTRGVPCHRRLDDNFAGDAGQDETMVGDGEDFKSAGGHSPGDDEDGWLRTGGLAASQLARAGDVRTVDESGNMGEREDDEDDIPDMEDEDDDEEAIIREPRDEEDTSTHRTYTLYITYTPYYRTPRLYLSGYLSGSQPLPPHLMMEDIVGDYKDKTVTLEDFPYFSNNIKMASVHPCKHASVMKTLLDRADAALKIRREKLKQGKTVPGAKDTGMEGLVDDFGKTGLADKKAILEGAKAGGNGNDEWEVLQHDMDATEDEEVAIRVDQYLVVFLKFMASVTPGIEHDFTMGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYR1</accession>
    <name>A0A3D8QYR1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF7728 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_09644</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYR1"/>
    <dbReference type="OrthoDB" id="5409353at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056145">
        <property type="entry name" value="DUF7728"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40622">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40622:SF1">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24854">
        <property type="entry name" value="DUF7728"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017774550" description="DUF7728 domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="285"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7728" evidence="4">
        <location>
            <begin position="43"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW66895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="373" mass="40707" checksum="BEE1C21A3A11E24A" modified="2019-01-16" version="1">MLHLAITVGLIAAGTQAFLIPPSISSTDTDIVNALPFEHAVEVDERTVDVKCPGCPIMASDLAGSPHLLQMDNELRLNFSIAHDNGDKLLLNGLQIYPLEAMQPWTDSLTAPQIVHVGKDASIAGYPKLGYQLSIEHPMPRTEVDQLDLFVVQLDILEVSNIFVNGVDSVELKLLTTPSNKMMIGDVNVVPALKPSLSVSNDNGKDCTSRICKWKAILADRLSRLQHGCGKKAGNSAHRGPKPHGHGKPRPHGFGGHHGAHSQHRHHRHKHTGLLHLLRQIAFHVLIPIAIGVMAGITASFVGMIAGHLVVFTWRLLFRRGCRGQYARLQHGSNVPVVAAEENKALIEHQGPPPVYEESPIYEQAVNCEKSDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYU3</accession>
    <name>A0A3D8QYU3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative transcription factor IWS1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_09721</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post-recruitment and recruitment steps of transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the IWS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYU3"/>
    <dbReference type="OrthoDB" id="21124at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.10:FF:000003">
        <property type="entry name" value="Putative Transcription factor IWS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051037">
        <property type="entry name" value="RNAPII_TF_IWS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010:SF1">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="8">
        <location>
            <begin position="266"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="367"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="39"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="372"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="445"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW66972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="454" mass="51400" checksum="4B0BEE9C9736674E" modified="2019-01-16" version="1">MSDSDLGSRPTSPPGENEDVNRPDSEDREATPPAANPDLDMDDEDNNLSGDDSDNDSLLSEVDEAEFADFDPTNVTLEDRPLVNIDEDVAKTLKAGKRKRVDGEKKPKEARRDKTKKKKTRRDDDEDPDGEQLDGKRVRKPKRAEGERKERDRTKERKKTPEPENEENLTPDERRRRALDRAMDAALKNPNKRRRKKDEVDLEEAFDDEIAALKIRMEQACEADNTAREKGQPAIHKLKMLPEVVALLNRNTVQHSIVDPDTNFLQSVKFFLEPLNDGSLPAYNIQRDLFAALARLPIEKEALLSSGIGKVVLYYTKSKRPEIGIKRTAERLLGEWSRPILKRSDDYKKRKIATREFDHQAAQLAIRPGAMPSSQSASQRGPQLSQRELDRERMLAPPKISNRARMESSNTSYTIAPRSTFDASRGPDPLTRPVGAGGMDAFRRMTAKQGKKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYX7</accession>
    <name>A0A3D8QYX7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_09738</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYX7"/>
    <dbReference type="OrthoDB" id="19102at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW66989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="314" mass="34287" checksum="A459250ED2B262BA" modified="2019-01-16" version="1">MSPLDVFFSAPPISRTLAAVAFTISLLTYTNVIPFHLLNLTLQSLIQFPPELWRILTSLLITSPMLGILFDTYFLYVFGAKLETASPRFAQRADFFYYICFECLVILLLNILIAGGSIFASPVSLSFICTSTRDSWDQPITFFVIKLPSQYLPYAILLLTLIIAGPQAAMVQATGLVAAHLYDVLTGLYPSLGIKSNLIPTPAWAKKIFGTQVMMQRPYGTVFMPTGGATTTGNAAWGLDLSWRRFGEGRRLGGEGESSLPSQRPSGLVLAAMVMAAFIVICAFLGLWFFWDGVPDGWLSAIGAGRSPGITFPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R2N1</accession>
    <name>A0A3D8R2N1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Diaminopimelate epimerase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_08865</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R2N1"/>
    <dbReference type="OrthoDB" id="75169at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.10">
        <property type="entry name" value="Diaminopimelate Epimerase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003719">
        <property type="entry name" value="Phenazine_PhzF-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00654">
        <property type="entry name" value="PhzF_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774:SF32">
        <property type="entry name" value="ANTISENSE-ENHANCING SEQUENCE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13774">
        <property type="entry name" value="PHENAZINE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02567">
        <property type="entry name" value="PhzC-PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016184">
        <property type="entry name" value="PhzC_PhzF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54506">
        <property type="entry name" value="Diaminopimelate epimerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW68208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="283" mass="29918" checksum="2CC71640EF3CE913" modified="2019-01-16" version="1">MDLSFTILNVFTSVPYAGKPLAIVHIPHSLSTLTPAQKLAIAQEFNHPATLFLSDLSPDATLAPIEIYTPTAPIPFASHAVLGAAFHLFRTRAHPHLRALVTIAGEIPIEAGEVLEIEGVEAEIPHAFHIYPRTAATPWPIVAIAQDMAFNLVELPDVAALANVSEGVTLAAAEEQDAPASVGTYYYVQPAVAHNVQQLRTRMFSRGEGGEKEDAATGRAAAALAGYLAVRDGAKFFQIMQGVEMGRESSIGVEVTTTADGRGVSRVVVTGGAVEVMMGSLTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R307</accession>
    <name>A0A3D8R307_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_09074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R307"/>
    <dbReference type="OrthoDB" id="3543906at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42749">
        <property type="entry name" value="CELL SHAPE-DETERMINING PROTEIN MREB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42749:SF1">
        <property type="entry name" value="CELL SHAPE-DETERMINING PROTEIN MREB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW68417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="617" mass="70091" checksum="1AB58FC0A830D823" modified="2019-01-16" version="1">MEAHQQGPSSDSASQQSDKETLVLGIDLGTTRVVVTFALDLPGNDVCEIETTRYWLESYRNTDYPSTDLLYVDGKDIPYTGPKVKELLKATNADMGRYFHMWKLLFHDPMDDESITRLQDDLTRRLKDMGKTKYDLLDDLVGVLYKDLLISDDKCRCYIQRRISPRHLENLEIKVVITTPPGRRVLEHEALVTAFERHPIKKGNVFLESETNAMLGGWVIGNRTHKFETGQRYLVVDAGGGTCCLTQFRVVATRPIQFAQEFVSQSILCGSETISEAYQQNVDGKLAADYPNRARTLQKMRYRFDKYCKRDFGYSAFPDGYCDSVTELVVPLHDLQKLFDTPVTKLLNATAAHLNVWAPADFIVMGGGLFENHSKSHIARGAVLAHMNKNFIGRYVAQHSIGIMVRREIDDLMEHHPFFHKLLTSIDADDNVRFLSVEWLIRKGEEVNAKHELSSGTCYDSAREVIFYPDEDDHPRFEDFVVTIDVNPGNDEYTACIEDDNVLQLIDFDGNVIANLNSLTVLKWCPRDILPTLANLEYIPLTQNKGEDAGSKGYKIVKLNWIVQPGLVMKFTIKVYNYGTTRSDGSMDYRTKLLQSTKAPFSKMMVSMGLSNAFDME</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R323</accession>
    <name>A0A3D8R323_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Guanine nucleotide exchange factor LTE1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_09007</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10254377at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007265">
        <property type="term" value="P:Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06224">
        <property type="entry name" value="REM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.840.10">
        <property type="entry name" value="Ras guanine-nucleotide exchange factors catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.870.10">
        <property type="entry name" value="Son of sevenless (SoS) protein Chain: S domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008937">
        <property type="entry name" value="Ras-like_GEF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000651">
        <property type="entry name" value="Ras-like_Gua-exchang_fac_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023578">
        <property type="entry name" value="Ras_GEF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001895">
        <property type="entry name" value="RASGEF_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036964">
        <property type="entry name" value="RASGEF_cat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23113:SF363">
        <property type="entry name" value="PROTEIN SON OF SEVENLESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00617">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00618">
        <property type="entry name" value="RasGEF_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00147">
        <property type="entry name" value="RasGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00229">
        <property type="entry name" value="RasGEFN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48366">
        <property type="entry name" value="Ras GEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50009">
        <property type="entry name" value="RASGEF_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50212">
        <property type="entry name" value="RASGEF_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-terminal Ras-GEF" evidence="5">
        <location>
            <begin position="385"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-GEF" evidence="4">
        <location>
            <begin position="1525"/>
            <end position="1768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="70"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="179"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="287"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="605"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="674"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="854"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="940"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1203"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1318"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1453"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="314"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="674"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="854"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="873"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="900"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="957"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1008"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1214"/>
            <end position="1234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW68350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1773" mass="195526" checksum="7FDBB29A70CEA6DB" modified="2019-01-16" version="1">MELASGIAADASMPVPASQSTLPHAVDAQNLRQRQRDRLSPRGRTPKSGRLTSTVRETGALAAKYAVKLSPAPRPKLAPANRSPDLSRTKQLSEGLRKENSVTTRVKRDGDDGKYDFVPDGGSAGREGRQFTVANVGNNGRIYLRPTVRPANQRYPQPSFVFPITPPSTAGLDVLVSQNDENDETPRGSLWTPTRSPASPAHHTPSQYFAEPSSAYPTRLRRAYSHSTIEESQLPVQDSDEGAFKIIIERPATGPATKDTETGGLPVLEVPIPSWKLGTPRFSMRGTPFLRNSSHTHSDDVRSSVFSSRDQSPRHSRPPRILSRRHSDSSPQPYVVGTPSPLGSASPLLPPASIIRLSTSIVPEMYDALTFKPGCDHPSVVRYASNGCIKAATPARLVAEITSPTFVDYDLLSDFFLTYRNYLDSSDLLHMLIARLRWALMRKDEPGTVVRVRTFVAMRHWILNYFLDDYVIDYDLRVSFCEQLNFLVEDLASDPTRSKVPLKVLDELKKCWRRVCSLYWDGYDFDTDFALEIPIAPGGIAGHRDPNLDPSFWEAHPDGPPRLEGIIEPDFVDPEPDSSTALPSRNFFADVSRAGHIDSVIASQDVPHVQEERQDDVEPPQSPGSIMSEDFVSCSFPTRFRAAVMPQPVGAHPVIPSSIYDSSAIATTPKALTGKRVRPTPAHKRSGSFSDSFRDQQPQSLHKVIYKSTEILMALPYAGSLVRGNLFPPGQAFVEEIAPGTPYDGSRATTLFPGTPADQKGPSAMSGPGMKKLLGSVRRALSTRTAPSHDTSPTYGSFPHITPLGIRGQTINRLPDTAIIPQARARNTGARAPMRIDLLGAEIAEDFKRAVREDAESEQERREASERLSAISKEQHIMEYSELHPETTIDSSKPGHSREPGSQLTNGSKSIVIVDDTLPLEVPGMKGALKTLNQSVDTFTDTFIQPSGGPTPPSTPPAAARGTPRRSSQALGRSRPLSFDKTPSLLNDPQDSPEAYTPSHRAFTRPSMRSRRSIGHRRSYSARINTSVSLRRYASFQSGMTRDHTERSFDATTFSGETNHLSGVPVVPRPLRVLRRRPGGDLRAVNNVGDLNTEPLRRPMSTGSLTTYSESIRSSFMMGGASNYVGAASGEYDDSMAPGQTFSLGQLAQSSPKPPASLFSTHSSQPIMRPSFEKEAQMLAQIPDDVNDDGGVESALLKLEGKFEQRRSDASAPRPSQQSPMDTNSFGAPHFDTSTLSLGEDEEEGYRHRMKLVAETNASKTAPVVNAYKPQTQTGQEELKPAVYRPTGMQTATIPMSPGSDGSYSSLPLLERGLSMDKKDRRRTRDWGSISGFEGPSIGRMTHQEHTPESSHPSYEFVKETDSMKRIPVGEANPAPECIRNSFDSYSDRSDLSSEMSLEVISRTEYTAENSNYSGFPPMRPGTVIKEMALPSHALGQPPSPPMTLVQALQLSPMTGHGPESRDYKVQPRTNSPLPPTPETTPILADGNFGEKGTSANSPDPLRMNRVIEAARKSSVHLPFTLAFDSQLLAQQFTLIEKDALNEIDWKDLTEMRWKDTQKESRSWVEFLRTSEPRGVEVVIARFNLMVKWAVSEIVLTQDIEERVRCIMKFIHIADHCRRYRNFATMTQLTVALTSKEIARLTETWSIIPAAELQTLDEMEALVTPTSNFNLLRAEMEGCGADQGCIPFVGIYTHDLLVNSERPSQIASTPTTEPLVNFEKCRIDATIVKNLLRLLEASQLYRFLPVEGVTERCLWLAALNDEDIARYGKIIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R3I5</accession>
    <name>A0A3D8R3I5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450-20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_09270</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R3I5"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF230">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017817115" evidence="10">
        <location>
            <begin position="17"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW68613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="478" mass="54232" checksum="ED4008E9FE651AF0" modified="2019-01-16" version="1">MLLVLFVLYIVQKVVYNLFFHPLSSYPGPKLWAISRLPWHWASINGRLCWTLQEFHLKYGPTIRIAPDELSYTTSSAWKKIYGQKVPEFSKCLDGRGIAPASRNGIRGIVTEFQDRHATLRRAILPAFSDRALREQEHFLQTYTAKLVKQLHHETGTVDIARWFSLTTFDIISELAFGEPGSCLDNADQPWLNVIGNRAKGIVWYQVGAYYGLDRVIQSVAPSYYLKSRKSHMQMCAAKVMKRLKKTDKMSDFMSYIINNEAAPLSNLDLTLMASAFIVAGSGTTASALAGTTFFLLRNPECYQRLVGEIRSSFLAEEDITMAATSELPYLRACVEEGLRMFPPSPSTLPRFVPEKGAFIDGKWIPGGIAVGVHQLSSGLMESNFHRAMEYLPERWLELPNDSPFAKDDRSATQPFSYGPRNCVGKSLGYQEIKLILSKVLWDFDLVLLDDSDAWWTQQKTFLVWEKKPLMVNICPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R794</accession>
    <name>A0A3D8R794_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_08310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW69913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R794"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF562">
        <property type="entry name" value="ALDEHYDE REDUCTASE II (AFU_ORTHOLOGUE AFUA_1G11360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW69913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="337" mass="36270" checksum="115F093A8CDFB3F0" modified="2019-01-16" version="1">MAVDLVFITGATGHVGFAVLTDLLKAGYRVRASVRKAAQGDMLKGHAFVQPFAENFESVVVPDGTVEGAFDKILDGVTYIEHIASPPPQPSEDPENDVIIPAVKGTTSMLYSAAKVPSVRRIVITSSGVAVIPTHALVNGDEQNTYTPNSRVRPLPTAPWGPPFFVYQCSKILALDAIEKFIVEQKPKFTIVNIVPGFVIGPNMLDTRPEQMLLGSNRGAMAPLLGLTESPRPTVISTLKDVARVHVGCLDENKVVGNKSFFVPSPKMAHDDAKSIAEKHFPAAVKDGRLPLGGTTPSVYLSLDSSETTEIFGEMGTYEDAVKELIEQYLALKEKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7U0</accession>
    <name>A0A3D8R7U0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_08504</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Mitochondrion inner membrane</location>
            <topology evidence="1 8">Peripheral membrane protein</topology>
            <orientation evidence="1 8">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7U0"/>
    <dbReference type="OrthoDB" id="344165at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0811">Translocation</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim10-like" evidence="9">
        <location>
            <begin position="27"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW70107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="96" mass="10829" checksum="539D744A06126651" modified="2019-01-16" version="1">MDSPTTSLDQNLDLSKLSPKDKQELQQFIVNESQKARIQQSVHSLTDVCWKKCVTGSIRSGKLDKSEETCAANCVDRFLDANFTVIKHLEAMRNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R979</accession>
    <name>A0A3D8R979_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_08838</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R979"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF21">
        <property type="entry name" value="QUINATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06960)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="353"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="412"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="485"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="32"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="535"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="536"/>
            <end position="552"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW70441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="561" mass="61056" checksum="CD540D1A2ECFDCA8" modified="2019-01-16" version="1">MGAGAKFLQWVVKNESMKSDPPEIYGWRVFMLACSACFGGMLFGWDIGSIGGIIVMPAFKKEYGIAGLNAKAAAALSANIVSTLQGGCFFGALAAYWVADRFGRKPALLTAALITTVGVVFQAASSGHIAVLYIGRLIAGFGVGAASMLTPLYVSENAPRAIRGGLTGLYQLFIAAGTMLSFWVNYGCLLHLTKNNVWIVPLVLQMLPAMQVLPLAEFWPELTVGYSCLFVGIALCNESPRWLARKDNWEKATKVLSTVSNLPPDHPYIQMELAEASYSWSGYHPLANIGGASFKDLMREMWTIKGNRNRALISIGLMVCQQMTGTNAINYYAPQIFQNLGIAKEQTGLFATGIYGIVKMVTCAAFLLFAADSLGRRRSLLWTSIAQGCAMFVIGFYVRFLPPVAGASIPPVGYFALTCIFLFAAFFQFGWGPVCWIVVSEIPTARLRALNVAIAAATQWLFNFVVARAVLTMLVTVGANGYGTYFIFGSFCFSMFFFVWFLIPETKGLSLERMDDLFGVTELAKNVNDEELGERVTSTDVAGEKNPTSMTTEHGLEAKQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCX4</accession>
    <name>A0A3D8RCX4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_07933</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RCX4"/>
    <dbReference type="OrthoDB" id="3524679at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033481">
        <property type="entry name" value="Dni1/Fig1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12351">
        <property type="entry name" value="Fig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW71899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="232" mass="24443" checksum="AB8A4ED6B723E783" modified="2019-01-16" version="1">MAGPFSFAITLSMTGCVSNSPGIPNIYLLKLQAQNGTNVLPVDFQIRLGYFGMCIGETKTLICSGSSSISILNSTSTNSTNSTNSTSTASTNLTPTTLLDTAQALQGRIILPFLVVAAGWFFFALPWLVLTQRGKVPPRHAQLFKHTAVRSLWLSVAIALVSAIATAQTAGALQYLTKSPAFSSISIEAGVTLQVLQWFLVIFSALFAYAVMVMLDEDTGPADGAVGKAGGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDB6</accession>
    <name>A0A3D8RDB6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_08087</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDB6"/>
    <dbReference type="OrthoDB" id="5345571at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057082">
        <property type="entry name" value="PH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057081">
        <property type="entry name" value="PH_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23076">
        <property type="entry name" value="PH_FT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23074">
        <property type="entry name" value="PH_FT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="46"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW72053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="173" mass="20377" checksum="4E60B8C375EE2BBE" modified="2019-01-16" version="1">MPETPKTSLTKTEMVLFHCTFVSLKARSPETFRMHPDDYRLGGERKLFQERIVDDGYAHYLSVFKDERTRGLRLQASVCEGELRKCPVWTAFVTHQSESLDWLVPKDRYRVWIMDIHLYVFCNAYREGHQRKQHGAFEIHFLEPEAAYRFEDLFYLTPSSSSSSIIEILEPGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDD0</accession>
    <name>A0A3D8RDD0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_07935</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDD0"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW71901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="166" mass="17944" checksum="5081754470621386" modified="2019-01-16" version="1">MAAEIVAGPMQAIGFQITWPKSHIVSDFKRGASAHWSEKGAQFAPSGRFTTPEIPDVGRARSSEPISKIGQKQWPSPNSELGRDTIGRISARLSSLGACIPAWEDIRKELWGHTRRPHALLASLGHVEGDPEPSLTAIGQSGHRCNSTSQASWAYTPPSDRVAARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDV3</accession>
    <name>A0A3D8RDV3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TBC-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_08132</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDV3"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000026">
        <property type="entry name" value="TBC (Tre-2/Bub2/Cdc16) domain family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000046">
        <property type="entry name" value="TBC domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="686"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="982"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="555"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW72098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1002" mass="109264" checksum="FDAD77DBF927C27E" modified="2019-01-16" version="1">MSSSASSIASSDNKSLTSFPSFSPESPSEERLLSVPLTDGTANSPFPAPSIKSLTTTPSTQLDRTALFDDVPLTLSNVPGAIHHANDEHIERLVARNGAVALVRQIAEDLAQRDAQIASLRRKAEDRERALRKIILECGLSNLDLETRLRVIEAESKTEERDRESAQDSGLEDMMNDAMTASALGPFNPVSNDQTIRAKDMLKSIESADAGKEAPRGWKDYIWGGTSKKPSRASSVNGEIVDGQMRGAASSTRPTVLQSDLFQNPDSGRSPSRAGSSQSATLPRDRKASSGLALWATKLVAGNTNSVRDSDASSIRGRSNSADETPGSRDPSVASIKTTMSSRTTVSAKAAPLKQGSRTIPSRRPIAATIPGNSTRGPVQERWDTMGASPQSTTSGGLDNYGPVEMDTILEPDAQPPTMTQIYNNPWNQEFLTDRFGFIYDQRRKKRQREAAEQIKKTKRGSRVEMISHVRGSSVVLDEGPLDEGSRPATPSSVEDKTEDGKPAKRWQDYLKIATFPTELLSHTPSSGIPAFEVMEGGEVPKSPGITTEERGFRPSATTTAAPSVPVTSDTATISGPDTTAPQPAALTKEDTEPVKLLLQQLGEVHDSLQREKTVKWNDFLRKVRAERKREGEAAAAAFSAAQRPMAVMPEVSLADGEMIGIAGLGNKGKVGRAKWSEFKALVLGGIPVAYRAKIWAECSGAVALRIPGYYDDLVSRKEEDDDPAIVAQIQMDINRTLTDNIFFRKGPGVSKLNEVLIAYSRRNAEVGYCQGMNLITACLLLIMPTAEDAFWLLTSIIENILPQGYYDHSLLASRADQQVLRQYVASILPKLSAHLEDLNIELEALTFQWFLSVFTDCLSAEALFRVWDVVFCVNDGSTFLFQVALALLKLNEQQLLQCSTPAGIYTYINHQMTNHAISIDGLLHASEGLRKVVRREEVEIRRTKAIEAEKDLVRQREVKNAQRRAERLAAVNGNGALNAPAVEVTAEDEELTVTTPVPIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RI27</accession>
    <name>A0A3D8RI27_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_07135</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RI27"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043020">
        <property type="term" value="C:NADPH oxidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016175">
        <property type="term" value="F:superoxide-generating NAD(P)H oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006952">
        <property type="term" value="P:defense response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042554">
        <property type="term" value="P:superoxide anion generation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000103">
        <property type="entry name" value="NADPH oxidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000004">
        <property type="entry name" value="NADPH oxidase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000778">
        <property type="entry name" value="Cyt_b245_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050369">
        <property type="entry name" value="RBOH/FRE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972">
        <property type="entry name" value="NADPH OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11972:SF153">
        <property type="entry name" value="SUPEROXIDE-GENERATING NADPH OXIDASE HEAVY CHAIN SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00466">
        <property type="entry name" value="GP91PHOX"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01169">
        <property type="entry name" value="NADPH_oxidase_subgroup_(NOX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="311"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="12">
        <location>
            <begin position="280"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW73693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="578" mass="66206" checksum="268F72A0DB5FFF29" modified="2019-01-16" version="1">MEKGNRSSTASTRVSERSRWPPLTRMLMSGEMSGERPRELNTRERFDRWMVNEGYRRFFVFIFAAIHAMVFSFGFMNYQIKDNLTIARTTFGLTYPIARSAALVLHFDVAMILFPVCRTLISLGRQTPLNGIIQFDKNITFHMTTAWSIVFFSWLHTIAHWNNLAQISAKNDLGIGGFLLANFASGPGWSGYVMLVALMCMALTSYEKMRRANFERFWYTHHFFVIFFLFWSIHGAFCMIQPDFAPFCVTVGSTAIGVFWQYWTYGGYIYLMERVAREIRGKHKTYISKVIQHPSMVCEIQVKKEHTKTRAGQYIFFCCPAVSVWQYHPFTLTSAPEEDYISIHIRMVGDFTKAVGRTLGCEIDRPKDKGASQVVSVNKNGPGSDGVDPAIRRVLPRVYIDGPFGSASEDVFKFEIAMLCGAGIGVTPFASILKSIWYRMNYPQKKTRLTKVYFFWICRDFGSFEWFRSLLLAIEAQDMDNHIEIHTYLTAKIKVDDATNIMINDANADRDAITGLRAPTNFGRPNWDMIFKSVRKIHAPAEAGVFFCGPKVLGSVLHIKCNMYSEPGFSFNWGKENF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIH6</accession>
    <name>A0A3D8RIH6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Signal recognition particle subunit SRP14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Signal recognition particle 14 kDa protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_07289</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of a fungal signal recognition particle (SRP) complex that consists of a 7SL RNA molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54, SEC65, SRP21 and SRP14.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SRP14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIH6"/>
    <dbReference type="OrthoDB" id="19209at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.10">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, srp9/1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003210">
        <property type="entry name" value="Signal_recog_particle_SRP14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009018">
        <property type="entry name" value="Signal_recog_particle_SRP9/14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12013">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02290">
        <property type="entry name" value="SRP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54762">
        <property type="entry name" value="Signal recognition particle alu RNA binding heterodimer, SRP9/14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5 7" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="40"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="114"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="114"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW73847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="145" mass="16313" checksum="EAE7A7839B1C98CF" modified="2019-01-16" version="1">MANVPLNNEDFFLRLADLFDERREKDHGSVFLTQKRMTYGEDENALEGPDTTSSLELQGLQPPKPAPIIIRATNGKSRGKRSKKIKLSTIVQAEELESFFVKYAEICKLGMSGLKKRDRSRRKKETKAKKKKGAIGVGEDATKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIU5</accession>
    <name>A0A3D8RIU5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Basic proline-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_07411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIU5"/>
    <dbReference type="OrthoDB" id="5400063at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="240"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="240"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW73969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="36862" checksum="8585322DF8596E1D" modified="2019-01-16" version="1">MEPVPETERMEEFRASPLPTLRLQDSSLYDNIAKDRDTPVRPTNLRRSTDPVPSSPLSPGWSSPMTYRPRNTSPFARGHMRSKSSTSALAPQMSRAQSMPGVNGAGHLLMSPYQRSASPSGSPSRVRTPRKPADEVFPTLPNRRSIELNDAFSPMSLSSEESTPKGLERSNSPTLGLNSPSNFRIRRPSSPLRQVSGGTTPTTPSSIASSSSSLASSPSYQTSRFNDVFLGAYNYPGSFTSSSVPSTPTSARSRSPSISSLETIPDSPDAEEAALEAERIAQLKADADAADGAEAKTKSLEGSTSRGRALGVAFGPRDKRKRWSVCGAERRGDLNLDTIWED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJ38</accession>
    <name>A0A3D8RJ38_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_07505</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000393">
        <property type="term" value="P:spliceosomal conformational changes to generate catalytic conformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18019">
        <property type="entry name" value="DEXHc_Brr2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18021">
        <property type="entry name" value="DEXHc_Brr2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000005">
        <property type="entry name" value="Pre-mRNA splicing helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000133">
        <property type="entry name" value="Pre-mRNA splicing helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.150:FF:000004">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000102">
        <property type="entry name" value="RNA helicase, activating signal cointegrator 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000368">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000004">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.10:FF:000001">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000062">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000254">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000013">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041094">
        <property type="entry name" value="Brr2_helicase_PWI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048863">
        <property type="entry name" value="BRR2_plug"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21188">
        <property type="entry name" value="BRR2_plug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18149">
        <property type="entry name" value="Helicase_PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="555"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="774"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="1406"/>
            <end position="1582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="30"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="233"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW74063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="2227" mass="251404" checksum="5CA6889D0790E438" modified="2019-01-16" version="1">MADQQRDVSQYKYSAMSNLVLQADRRFVSRRNDEVTGDPESLAGRLSIRDMGSRNAREDAPKQKKKASGLPDVERGGFREGEDVLEREQRKRKRGEPAQLRGAGILSEADALVEGIRYRPRTSATRATYDLILTTVATSLGDVPHETVRSAADVVLEFLKDDDLKDFDKKKEIDELLGSSLNPKQFNELVNLGKKITDYDAQDEDENMVDGENGGEDGAEIDDRQGVAVVFDDNSEDEDGAEMVNEVRDESSEDGDEEDRPAAEEVATAGGAAMDVDAEAFALPEEEAMMIDSERNGSNGATKKEKDSIAARDIDAYWLQRKIGLIYTDAHIQQEKTQQALHILSGDSEEGAEEKSLREIENDLMELFDYEHHELVQLLISNRDKVVWLTRLARAEDAEARGVVEREIASEGLRWILDELRGGASADRAKKAKVEIKMDIDVPAEYMADTTKSEGKEVGLVGGLQPRKTINLENLVFDQGNHLMTNPKVKLPEGSTKRTFKGYEEIHVPAPKKRNEPGDRDIPVSEMPEWSRGPFLRAGGTGEPKLNKIQSKCYPTAFLDDGNMLICAPTGSGKTNVGMLTILREIGKNRNPETGEINLDAFKIVYIAPLKALVQEQVGNFGARLKPYGIQVSELTGDRQLTKQQIADTQIIVTTPEKWDVITRKATDLSYTNLVRLIIIDEIHLLHDDRGPVLESIVSRTIRKMEQTGDPVRLVGLSATLPNYRDVASFLRVDPVKGMFHFDGSYRPCPLRQEFVGITEKKAIKQLKTMNDITYTKVLEHVGTNRNQMIIFVHSRKETSKTARYIRDKALEMETIGQILKSDAGSREVLTTEAEAINDRELKDLLPYGFGIHHAGMTRPDRTSVEELFSGGFIQVLVCTATLAWGVNLPAHTVIIKGTQVYSPEKGSWVELSPQDVLQMLGRAGRPQFDTYGEGIIITTQSEMQYYLSLLNQQLPIESQFVSRLADNLNAEVVLGNIRTRDDGVEWLGYTYLFVRMLRSPGLYSVGAEYEDDHALEQKRVDLIHSAAVVLEKSNLIKYDKKSGRIQTTELGRIASHYYITHSSMLTYNHHIQPSITPIELFRVFALSEEFKYIPVRQDEKLELAKLLGRVPIPVKESIEEPHAKINVLLQAFISRLKLEGLALMADLVYVTQSAGRILRAIFEITLKKGWSSVAKTALELCKMAEKRMWPTMSPLRQFPGCPRDIVQKAERIDVPWNNYFDLDPPRMGELLGLPKAGRTVCGLVSKFPRVEVQAQVQPMTRSMLRVELTITPNFEWDDDIHGTAESFWIIAEDCDGEDILFHDQFILRKDFAQAEMNEHVVEFTVPITEPMPPNYFVTVISDRWMHSETKLAVSFQKLILPEKFPPHTPLLDLQPLPVAALKTQDYVDLYPNWQRFNKIQTQTFNSLYTTDDNVFVGAPTGSGKTVCAEFALLQHWKHQDAGRAVYIAPFQELVDLRLKDWQDRFAKLRGGKEIVKLTGETTADLKLLDRGDLILATPSQWDVLSRQWQRRKNIQNIQLFIADELHMLGGQIGYVYEIIVSRMHYIRTQTQLPLRIIGLSVSLANARDVGEWIDAKKHNIYNFSPHVRAVPLELHIQSFTIPHFPSLMLAMAKPTYLSILQMSADKPAIVFVPSRKQVRATARDLLLACVASDDEDRFLHGDIDQMKPLLDRLGEEALAESISHGIGYFHEALTSSDKRIVKYLYDHGAIQVLVASRDVCWELDSTAHLVVVMGTQYYEGREHRYVDYPLSEVLQMFGKASRPLEDKLGKGVLMVPAVKREYYKKFLNEALPIESHLQVFLHDAFVTEISTKMIESADDAINWTTFTYFYRRLLANPSYYSLSDTSHEGLSAHLSELVETTLKDLAEFKIIDLDEEDDSVAPLNAAMIAAYYNISYITMQTFLLSLSARTKLKGILEIVTSATEFESIQIRRHEDSLLRRIYDRCPVKMAQPSYDSPHFKAFVLLQAHFSRMQLPIDLAKDQEIILTKVLGLLSATVDVLSSDGHLNAINAMEMSQMVVQGMWDRDSPLKQIPHFTPEVIKAANESGINDIFEFMEAMDPSENPNYEALVKRLGLSQVQLAQAANFTNSKYPNIELSFDVEDPENITAGDPAYIKVQITRDVDEDDEDNDVDTTVHAPFYPVKKMENWWLVVGDESSKTLLAIKRITIGKVLNLRLEYTVPTPGEHELKLLLMSDSYVGVDQDPTFKVSVAEGMDEDEDEEDGEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJA6</accession>
    <name>A0A3D8RJA6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Delta(14)-sterol reductase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">C-14 sterol reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Sterol C14-reductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_07488</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ERG4/ERG24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJA6"/>
    <dbReference type="OrthoDB" id="67965at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050613">
        <property type="term" value="F:Delta14-sterol reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21257:SF52">
        <property type="entry name" value="DELTA(14)-STEROL REDUCTASE TM7SF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="1" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="1" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="1" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU369120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW74046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="275" mass="30802" checksum="11393BBEFF10CD14" modified="2019-01-16" version="1">MSTTKPKADPTGIQRGDYSNPKLSPALFFIGRLMNIPIQLAILTSSPFSNMFPRPPPPSGGAPILRHIPSSMAPFLSRILPLTASATTVTLTLTPYQAIITTMSAVLVAKHLIWIAYLRRERLTWQFAFFGTLPEWIFEGLENLLFTFAAVNPFWSPSLFYLAAAMHIPAVLLELTAEIQRKIFKDDPKNKGKLCTTGPWGLARHINYGCNIIYGFAYGMACGGIPAGIIFGGVYLLNFVFNAGPSIEEYCQERYREKFDAYCKKVPYKYIPWLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJF5</accession>
    <name>A0A3D8RJF5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="25">Iron transport multicopper oxidase FET3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BP5796_07625</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="16">Cell membrane</location>
            <topology evidence="16">Single-pass type I membrane protein</topology>
            <orientation evidence="16">Extracellular side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJF5"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033215">
        <property type="term" value="P:reductive iron assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13851">
        <property type="entry name" value="CuRO_1_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13877">
        <property type="entry name" value="CuRO_2_Fet3p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13899">
        <property type="entry name" value="CuRO_3_Fet3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000022">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000024">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000025">
        <property type="entry name" value="FET5p Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044130">
        <property type="entry name" value="CuRO_2_Fet3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF361">
        <property type="entry name" value="IRON TRANSPORT MULTICOPPER OXIDASE FET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="12" id="KW-0186">Copper</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0410">Iron transport</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 19" id="KW-0732">Signal</keyword>
    <keyword evidence="5 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="19">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017541753" description="Iron transport multicopper oxidase FET3" evidence="19">
        <location>
            <begin position="28"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="557"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="22">
        <location>
            <begin position="34"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="20">
        <location>
            <begin position="159"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="21">
        <location>
            <begin position="368"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="588"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="623"/>
            <end position="632"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00037814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="RDW74183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="25">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="632" mass="70276" checksum="9AB4CCE85BFDA42E" modified="2019-01-16" version="1">MLPKCVSICSRFFTCGIFVAALAVAETRVYDFEIGWASRNPDGRHERRVIAINDQWPIPTIEATVGDRIVVNAHNHLGDRATSLHFHGLFQNGTNHMDGSIGVTQCPIPPGASMTYDFVVDQPGTYWYHSHETAQYPDGLRGPMIVHDPNHPYAESYDEELVLTLSDWYHEEMSQIVKDFLTVTNPTGAEPVPQSALQNDTHDLQVPITPGKKYFLRIINLSAFASHYFWIEGHEFEIIELDGVYHEPTKAEMVYLTAAQRVGVIFTAKNETSRNYAMVAAMDQEMFDVIPDDLIPNAVSYLVYDASKPLPVPEPVDEFEPIDDFNLIPTDREEIFKSPARTITLNVSMENLGDGANYAFFNNITYKTPVVPTLFTALSANGDDAMDPLIYGDYTNSFVLDQGEVIELVLNNKDDGKHPFHMHGHNFQVIVRSEENAGAWDPAEASEFPEIPMKRDTVMLQPQGNLVLRFRSDNPGIWQFHCHVEWHMKQGLLVTLVEAPLALQKTLNIPADHLAVCQAAKMPTEGNAAGNTVDWLDLTGQPSPPKPLPDGFTPRGIVALIFSIISGLIGTVVIFWYAYGDIPDQSEEEQALGSGSDRSGYEGLSSSNGHSFEEDNGPNGSRVPDETARLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPH7</accession>
    <name>A0A3D8RPH7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PhoD-like phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_06784</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9999821at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF1">
        <property type="entry name" value="PHOD-LIKE PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="974"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="1242"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="903"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1401"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1635"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="209"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1459"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1475"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1525"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1635"/>
            <end position="1645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW75963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1683" mass="188618" checksum="841BD36E3109B06B" modified="2019-01-16" version="1">MSAPYWGKLPPPAVVRHPSTRREEGNHPKLTVNTQTDPYMDPSAASSQSRQNRHSTQTAATTSTQSPFVSPLASSFEPEGLAPRPGSYKYGAQYPSVQLDANKDYLEKRRRRETRNRDQFYEDTAARPPPPPAPDAPRPPPPVSYKQSSGEIPVRSNSNRHRATPSDYHEDDYHVDGRAYNDIDPKSSRANGKTISRSGTVDSRRDRSGYSSSQPRRVSASEAEERRRREWAAERSPLQRLESTLDSITKEEKRARVEEAELRAREAQATGRGDARTNENSVRFRNRPVAVKPSEEIASSSIDTAQDIDPAHTEKLQRSRTVQRSNFDATAVTSTKGSKPIERRPQQATIDNNSRPDKEIPQRGASVRDKAGVPVAAALAGAGAVAGASLSRSRSNKLKKEPPGDPWYQRRKEGEQKYNQVVPKRAFVDDSADTRRGIPQNSAHMQEESVVRRPIDQYDSDPEFMDTAVPVRRGSIKKIEQLTGHKASDPRSTSAMQQKPNGVARSTGNGSIRVIDRETQPNAHLVNWTKYSEPPAVAGPNKHNDAPHHKQDRHHFTNLLHHRHNEVPGGGVYVPQPRLNEWKKGGTALLAGELLDLNITNEKNEAEKDKAWWEAGHTGKRRASTSKQHSAEAFDGGYDDSNGKGTSHVSNNECGPCILENDLEWTSSEVLVTPRARRYFGYLGDSSKEKKRQRSNKSWLISPGSHPATTEHKSASKLFSLFSFNPLFQRQAIIDKSSFILFKSSTRKEHSLTCTTRPIRARSVIAPTRFKPHLFLKSGPFLRYCGMRRERLQNPPGRLPAAAMEREIWRGSVMIVTADEHSSYEFAPVLRLFSQPMELLPPPPAQVDGSLGNLPQEYIDPLAGLPKLGRDGRTLYIRPVEHLEEEKDLSKLESDDGLFEMRRSNLDGTTDKNPRPKQRPRIDGEKLGKYKEVKGIRLHAERGVTFWRFNIEIELKSTQQRIAYRINRGPATGFWVPGRDQAMNIMFHSCNGFSLSVNPDQFSGPDPMWRDVLNTHQTRPFHVMLGGGDQIYNDAVMDGSTLFEEWLRIKNPIHKENEPFTPELQDELESFYLQRYCMWFSQGLFGVANSQIPMINIYDDHDIIDGFGSYPDHYMRCPIMSGLGSVAFKYYMLFQHQSSIDEGEDTEPSWILGTRPGPYIPELSRSVFTNLGRSIAFLGLDCRTERMHNEVVSAESYDKIFNRLEREIIKGVTRHLIVLLGVPIAYPRMVWLENILTSRMFEPVKALSRAGILKKGLLNTFDGGVEVLDDLDDHWTAKNHKKERNWFIQELQELAADKSVRITILGGDVHLAAIGQFYSNPKLKIPKDQDHRYMPNIISSAIVNTPPPDMLADVLNKRNKVHHLDHETDEDMIPIFTHDVTGKSRNNKRLLNRRNWCSIRQYDPELTPPPTPGTPSEERSPSPPPTRGILRRFSTSKGPSYRPDAAAPPLSSAGGFFNRRPSFSSRRSSIDSQRPGSLTRTLSLTRRDFMPGNLFRKKRRPDDGGINGYGAESDSDISPPERSGLRGGSGGPVGGPTDEDYFSRSRGKEIGNPVDQATTSVAGGTPHAGGLVRSQFHRTPTGLSGKQKKNAADGRHDVNLEGGLDICLNMEISQKDPAGITMPYRLLVPRLWYEAEDESESESESGSESGSSRSGGGSSYSGHSGQGRRRGSGLSRLMSFKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPJ7</accession>
    <name>A0A3D8RPJ7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_06711</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPJ7"/>
    <dbReference type="OrthoDB" id="3564679at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="384"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="559"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="23"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="570"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW75890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="590" mass="65254" checksum="27DA42530E5A8DE2" modified="2019-01-16" version="1">MSQNGIKGTMTPKMLEFERQAEARAREQEIMEAEQERMLEEQARMQEEQERIAQEQYEMEQYYEAEALKHADEMRIHQEEVRRHQERVREHERMVRDHEASMEAFAKVIAMPVKPARGRQVSFLGPPRGSANGRASNSSTTHHVQALPASIDRGRNRKDAQSATPRATASLANIMNSGDGANDSIPTIRQEPPLALSTTSDTTDFAGNPKASLAPDQIPETQGGFFSRVFSASTPANTSTADVAEWQRAVSIEMTIPAFEDSSQTTPVPIVLSDGPQEVTSPARSTWNAPALENSPSADNQIANNIQEPAVQNLLQVRPTRLWELDPSDRIVEPSPAESRISAVESGLYSDDDTLSVPTTRRNSNTLLRPRSWLGTETWHNSEIDMNPEVVRGDDDEATRSQAALDPATEERPSVPLEDDASEQEPTLSRRSLRPRPQSAFSIFQYLEPDIQNEARIQERIEHAWSSRTPIVRRSRSSTLSTNTVNTTARNSTFSTLDGRRTTFRTSVASGFSNRDSVERRQSSDILRPLWLKEGIPEERKMERRVSLLNRQIDSLLQGLKTEPDAEGSATGGGDGGGSGTGSGGDGGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPQ3</accession>
    <name>A0A3D8RPQ3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Carbonic anhydrase</fullName>
            <ecNumber evidence="4 9">4.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_06771</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 9">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the alpha-carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="4 9"/>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPQ3"/>
    <dbReference type="OrthoDB" id="429145at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03124">
        <property type="entry name" value="alpha_CA_prokaryotic_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.200.10">
        <property type="entry name" value="Alpha carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041891">
        <property type="entry name" value="Alpha_CA_prokaryot-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001148">
        <property type="entry name" value="CA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036398">
        <property type="entry name" value="CA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023561">
        <property type="entry name" value="Carbonic_anhydrase_a-class"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018338">
        <property type="entry name" value="Carbonic_anhydrase_a-class_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18952:SF265">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00194">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01057">
        <property type="entry name" value="Carb_anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51069">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00162">
        <property type="entry name" value="ALPHA_CA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51144">
        <property type="entry name" value="ALPHA_CA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alpha-carbonic anhydrase" evidence="11">
        <location>
            <begin position="52"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW75950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="307" mass="32293" checksum="DCBEB484324F34C8" modified="2019-01-16" version="1">MVSFTYLRPAIAASLLLDISSASCAHGTHLARRSTYSTLNARNELEKRVDVSTFGYHGLTGPTNWDALDPANSACSAGRTQSPIDLTGGSVKTIAGNTLNITMSDVATTELENLGSTVEVIMAGKGASITIDGKTFNMAQYHFHTPSEHTIDGEYFPLEMHMVHQAADSSISVLAVPFQLSTDGSTTETVTASMAGLAEITTPGTLTEVTALPLSKLATALSAQTFSTYSGSLTTPPCTEGITFYVATKPMAMDVATYNSIKAVVGFNSRFVQNAPGGVNVLASSRSMKSKKTKKTKAEVAKPYGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RQ28</accession>
    <name>A0A3D8RQ28_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_06980</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RQ28"/>
    <dbReference type="OrthoDB" id="2283488at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF12">
        <property type="entry name" value="TRANSCRIPTION FACTOR ASQA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="35"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="668"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="73"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="684"/>
            <end position="693"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW76159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="742" mass="82544" checksum="BC9C2D1F480EAEB7" modified="2019-01-16" version="1">MSSSTANTAPTGVSGFADAPRAQHFRQKRRQVARACDGCRIHRIKCDSSQPCSNCKSRGRHCSNNDAAREGSLSQACGEIERLRKKVQELEEKLEEVTAVNPEQQLATPSSMSLAPSPFMAFKSNDVDQDGNPKKKFWEGVKLRPARSPHATWFGPSSLYFFIKNLSVRLSASLQLTHSDDHILLKSVSTLNLLDGPGAPCEDKITPAVDEAKVPVTEADLSPTQEEYFINLFWQSYHTSLFAIIDEAEFKQHYQSLWMTSGNARKSSALVDIILAMCMQYAISTLPVGEQGNIAGNADATIAGRWLYRRCQTLLTYEMESPTISTLQCHLLCAIYLCGGSFHNMVGTSSGLAVSTAYILGLHLEPPQDMPEREQEKRRRLWWAVYLLDSKTSMKLGRPFLVHDSYTMPRLPSDSPQAAMLSGSTFAPLGDNATWLSFNLHNTKLYMAVRKAQTAFYDTDFGLRDGQTILDDAQALEACAELLLPHMKYLEEWANGVPNALKTKRHNDGRPFSTDGSALEIEQFAPLWLQRQRLLLELTYHHLCVDLYRFFISLDSVSTSGLLVETMATACAAHAIALTKITNQIFSSTSILDGWHEIFQWQWNATITLVGFVFTYPQGLSTPLARNAIDLSESVFDNFGAKFAVAVGAANIVRDLSMKVDFLAMQNQSNQRDSNQEEAPVTNYGHSNEQTSMDNNLSMPNLGNIDAGFYDMSDGSNQDLMDIALSVDFWGDFDTLWPNAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RQP4</accession>
    <name>A0A3D8RQP4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_07025</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RQP4"/>
    <dbReference type="OrthoDB" id="3583210at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW76204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="505" mass="57722" checksum="1791EF011E80DAB1" modified="2019-01-16" version="1">MAPLSFDLTTKFAAWTLVLGVACPALYVLWSITYNLFFHPLRSYPGPLLWRISRLPRDYYNLKGELHVPMLAFHKKYGTVIRIAPDELSFASAQAQKDVLSISPGKVEFPKDPRRLQRTPNGIMPISGADKDTHARYRRLLSHAFSERGLREQEPRIQKYADLLVQRLSEKAEANEATNMIDWYIMTEFDLIGDLAWGDNFECLKTGIKHQWIIASEQNLQHVSHMAVLRRWNLDSWGSWLLSPTIVEGRKKNFEQAQQLMDKRVAYDGPPRGDFWDHVLIKSENDNEKGEGLTKAEMMINASVLVVGGMEPVSTALGGATFLLLKHPEKMQKLLGEIRSAFTSAHEIDIQAMNRLPYLHACFEETMRLYPPAPTPFARVPPVGGGMVDGKHVPEWTEINLLPSMGNRLESNFHRPDDFVPERWLKDAPVEFANDQKAACQVFSLGIRNCIGRNLAYAESRLIMTKVLYNFDLELAQGQDDWLNQKIYLVWQKGPLYVKLSKVYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RW44</accession>
    <name>A0A3D8RW44_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_06139</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RW44"/>
    <dbReference type="OrthoDB" id="2147163at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668:SF1">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G01940)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="32"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW78287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="243" mass="26373" checksum="09AEB83CCBE14488" modified="2019-01-16" version="1">MSEHSKACCSIPPVVANGYEAKGSYSQVAGLKTYITGPSDSKKAILYVYDIFGFCDQCLQGADILAKTHMVIMPDFFDGAPAHLSWFAPGSDDGQTKLGEFIKTKASPPLHLERIAKVVEEITASKGVTEWGAVGMCWGGKVVTLCSGAGTKWKAGAQCHPAMLDPKEAEDISIPYATLASKDEDKDTVVAFGKASKAETIVEIFEDQIHGWMAARANLEDERVKSEYARGYKILNDFFANYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWE8</accession>
    <name>A0A3D8RWE8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_06158</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWE8"/>
    <dbReference type="OrthoDB" id="4721035at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="229"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="809"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="88"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW78306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="928" mass="101064" checksum="8BFF56F94CB5DCBB" modified="2019-01-16" version="1">MAGHAPDRRSLLRNEGSDISEASTAIDSPVVKSPPHHRHTYHRMASNGSFNSQHASIHAISEADEADGAAEGSVRGLGIENVTTGITASSTPITRVPIGTDRSSARTSPMHFGSSRAFSTISFDSNTKSSPQTPGSGKPLLPSPAWARFDDGIYTHGCEGDQQQDTQEQDISKGNISTFSEDLGPTPPGYKGTHTPKTSASSINNDDQYGVYVPPCTTKNDIHTGRSSWLSVSIMVLSVYSTVFSGIWLMLALVRPRYGKAIHSGGNLTPATASIVFALFAKTIELSFVTVFVTFLGQVLSRRSLVKTSRGITIAEMSMRTWVIQPGFLITHWSHLQHVGVTMLGGITLLAALIAMFYTTASDALVSPHLKFGKWEHREMSGWVETSYANPYFIKDNCQTPVTTLMDPDNAGLTCLAIEHAGQAYHNFLVYMDTWATISALGVGESTDISQRPAPVGMLFDNTTVTGSWVHANASNITASYEKYNRIINNVTVSMPHANVFSAARDPINGVLQPAELAGVGEYVLQASVVSPTINVLCVNMKEEELAPLTYVTWPNAQYSTTTLIPGQRTAWSGYEDEVQLLPGQEYLNSTVVDDIFEWGAAYGRQPPVFPMVPIDYNSITNISVASSDSIYILVKAPASTTTNYTLCQMRSFLSPNCSTRYNVSGTVGGNLGSHCEDPSDPMAYSKSFTDSPISPSTDWRNVISEWALSLSLNTGVSNANSSTSRLLSQFITAEPSYGAAKLNGLLPSIAEALSVLSGCTLLLSTTSSTFYHYWAYDATTLNPGTYQPFNASISSQQYTSGYTQNWQAVFYLVLLLVFSMNVFCLTYFFLRSGLVTDFTEPPNLFALAINSPPAQRLSGSCGAGPEGDQLNVDFHVGMDEHNNHVYIKEGGISQAARNYEMRRRRQMQDFRSVTSYSKLSNKRRSWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWQ4</accession>
    <name>A0A3D8RWQ4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_06212</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWQ4"/>
    <dbReference type="OrthoDB" id="3525388at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="261"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="86"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="216"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="346"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="293"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="394"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW78360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="417" mass="45791" checksum="FA210964A47C531A" modified="2019-01-16" version="1">MDGPPMTPTSALLYTYLELDAFKTPDAVAAAKAGIDLSYTEQDVFAQAFGIHDTVDVTEAKQRAAESFKNIAHPQQSETTYQSIYMSPPLSTDATGDSPLKEMSDLETSSKKSSIASMSESNESVVLSDLPSYLAHVLSTSSPDDFFSYAQKTHYGMQHGQVPDQEMCGDENLPHEVAIYSDNGQDPSWNPCDLAGGAIPLVGKLYNEQLLPKRQQQQSIAPYSGAPMSTTSSQPTASASPITKTKKTRRRRNNRSAEEEARRHQEFLERNRKAAGKCRSRKKDRVQKLVVDVDEARAWNGELKAEKNALEQEIGELRKLIGGCGCACLSAAKVGISMLTGKEVSQNDAADSGAPADELRRANAQRDPSDEKDMNKLNPSCEIDFDLEMDDLEMVDLDEEQEEEETMEATGRDITDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWV5</accession>
    <name>A0A3D8RWV5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative propionyl-CoA carboxylase beta chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_06357</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWV5"/>
    <dbReference type="OrthoDB" id="439921at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004658">
        <property type="term" value="F:propionyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000110">
        <property type="entry name" value="Propionyl-CoA carboxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051047">
        <property type="entry name" value="AccD/PCCB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43842">
        <property type="entry name" value="PROPIONYL-COA CARBOXYLASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43842:SF2">
        <property type="entry name" value="PROPIONYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="2">
        <location>
            <begin position="317"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW78505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="576" mass="62752" checksum="F0B9A16A45DBDF67" modified="2019-01-16" version="1">MSDGNGPRSSSDANQRLSQVAGHLRSKKQPSRLSKSKAKDELPADYSDVLSQLDMLRNIASTPDLNSSGYVRQKQAGKLWVRERVLSLLDEGSFREVGSVSGTVEWRRLKGTKEEPISFIPSNNVQGFGFLRGRKVVFTADDFSLRAGHADGALMEKTIHMEKLALSLKLPILKLVDGSSGGGSVTTITKNGFSYVPPLPSFDYVVRQLNMGIPNLGAVLGPAIGLGAARVVSCHFSVMAQDVGALFNAGPKVVAGATFEEGLSFTDLGGPSMHCTNGTIDNLAANEQECFEQLRTILSFLPNHGLSLPTRGPAADPADRVCEALRTIIPRRKARMYNPRTIITTAVDESSWFEIGRLWGTTAIVGLARLAGFSIGIISLNCEVNAGALDAAGSQKITRHLKFCDVFNIPILQFVDIPGYAIGTVAERTATMRHGVQLATTYYSTTIPIFSVITRRVYGVAGGVMLDCRDPRMRVAWPSGEWGSLPLDGGIEVGHAAELKAAEKQGKREERYKELEEEYVRLMNPVRTANAFGVEEIIDPADTRAIAVEWCKHIYEELLPLRILDRANGKTNPIFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S313</accession>
    <name>A0A3D8S313_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cell morphogenesis protein-like protein PAG1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_05363</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6287725at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000902">
        <property type="term" value="P:cell morphogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025614">
        <property type="entry name" value="Cell_morpho_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025481">
        <property type="entry name" value="Cell_Morphogen_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039867">
        <property type="entry name" value="Furry/Tao3/Mor2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029473">
        <property type="entry name" value="MOR2-PAG1_mid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295">
        <property type="entry name" value="FURRY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12295:SF30">
        <property type="entry name" value="PROTEIN FURRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14225">
        <property type="entry name" value="MOR2-PAG1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14228">
        <property type="entry name" value="MOR2-PAG1_mid"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14222">
        <property type="entry name" value="MOR2-PAG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cell morphogenesis protein N-terminal" evidence="2">
        <location>
            <begin position="343"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1173"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1440"/>
            <end position="1707"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis central region" evidence="4">
        <location>
            <begin position="1739"/>
            <end position="1924"/>
        </location>
    </feature>
    <feature type="domain" description="Cell morphogenesis protein C-terminal" evidence="3">
        <location>
            <begin position="1956"/>
            <end position="2206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2472"/>
            <end position="2528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="168"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2483"/>
            <end position="2500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW80665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="2528" mass="283123" checksum="FC657CCA8D3D7391" modified="2019-01-16" version="1">MERLQDQSKASFTIRGPHPINNATLKPSVNSPTPSSTQSPTHSRESSRDQQSLRGLTRQSSSTRLHSQSPSGLSPRLGGRGGLGDRLAEVKNLPYGHHRQTSIVHGIQHSRNGSFSSSTGPLSPEMISAAGMGGSEGESISATLSSMNSGRSFASNTTLVPDRPATSMEVTAPSSSSQKRVERMHSGKSRRDGHHHSHSRHHKEELKTVGEYALHVLFTSFIAQAEEKISRCITIPFDPEPHIEPICGPGVDPAFDQLISALGHIAKQKPKPLIDGMMLWRKNKSDAANEARIQLQQAKSNLVPGPMLRRNTEPPHMLSDAMNGPVSTQPTVAALQELVAQAERRSTASIYILCRVLMEVISQSNLTCITTEMEEKLEAIIFNQVKTYDVETLANSPLRMANWCLFGELLGAMSEINFESVTDRFIADLEKAQKDLVQVKSPGNRETEGRMELVLGGMKHLRVKIYPEEAWDQSCDFMISLGRFFSQSHGHRLKYAYCQVLDILLLPIAANANTELNMPKWTEVLGTVGPRLASMFVKPRHWSVAFPMTATLLCASPIETFSTQWLQLVLPLQPKLKDRITRPICLQVISRLLWTYLYRTVDSQIASIKKLDEVMKLVLPSGRRTFLSTDPSIAEPLIQIIRIIGFKHQEFCLRTIVFPLINADLFASGRDLKVEQLEPEKMVIGIRAFLAIMADLEKGEQGRPPFPQQYHPVSMFDRVPSSPILIPPRTPMLAEPASNREERLSRPVLTHVLSEVAQEYYGRFCEILGKITIICDNTFGGQAVLDEKFNTPAPKTPIAETFNFRRDDHQGPSDQKQGFYELLHVAVQALPRCLSADIPFNSLVNLLCTGTAHVQYNIAASSAQSLKSIARQSHAQQVTIGFARFIFNFDDRYATMSDGGMLGPGHIESTLKLYVELLQIWIEEIKQKTREAAADVSEEGTQDKRGVQLDLSGIWAHVDEVESHGLFFLCSQSRRVRGFAVNVLRLITEFDTALGKDNSRLIHILEGDSKSVMNFNDEHLSVAERSRLQRGMRKSNSQSALIELCSSEVSYDTTLWFKIFPNLIRISYDRCPFAVTLGRELICNRILQMYKSILLLSEANRGPQYTPFDRFEMGSGRMLARTPTTPPEVLVEQWKLYLIVACTTLSDKGGQLSPVPPAQHARKGSKAAPGLEKITSARILFKYLIPLLAVNPASIRDAVVVSLGSINVNIYKTLLEELQGAVSRCNDDARARIHQRTASSPRRNRRTDLLRTEVTHVYRLTSHFLKEAEIFQDDWILNNLVVYTKDLKLFLMDGEVQMDWEFQKLRRHYCGLMEELFDGINRTKDPSRWMTFESRKSSFALMEDWCGYSPNQTQISQREQSMRQSMMDQQSLGERGTATAAMEIEKRNLRTAALSAMAALCGGPVSITTESRANLQFDIRRMLSWIDTIFSTGSDRMHVIGRRALKNLIVHNKDFPYLLEHSIARCYGAEPSKVLESYFEVVTQVLVENPDYPMPFWKLLGIGLYTLGSELSEIRSKSAHVLRALEERQQRSSKIQDFDISISDKTKAVYKLAQFEISKRLSKQHCELAFLIFSEFTAYFKDLQPVAQRNMVAVILPWIQIIELQVDPNGGPTAQSYVLLANLFEITIKCSSVLHNEVQALWQALATGPHAGNVQVVLDFIMSLCLDRREQNFVEYAKQIVVFLSSTLAGGKVVEFLLMQITPKAMIPNERRELIPPPPDTGTMPYLAELSEALPIGTKQAGFSLGQLSLILLVDLMVSPVQLVPENVPLLLQVVTVLWDHYIPLVQEQAREMLTHLIHELVISRIDDEQTTPTKESIEDFIESIRRSDPNVIWAYEDSNGKPDEDNKVPSGMEYLTTQVVGDFEVTYTGIQEQWAKLSLTWATSCPVRHLACRSFQIFRCILTSLDQPMLADMLARLSNTIADDDPDVQTFSMEILTTLKTLICKLGSPDLISFPQLFWTTCACLDTINEREFLEAVGMLEELLKKLDLSDPEVRVLLLEGRPARWDGQFTGLQPLVYKGLKSSVCLDLTLKTLNQLVLLPSDELVGDDTRILFAVLANFPRFLHAMDQESIDADVAQTATILAQVADAQGCSTMSRALSGFAASRYRSSKDFLAQLISAIRESFFPQWDFASLIFLMGLLTNSIPWFKLNTMRILCALIPVIDMRKPEIASHGPDLISPLLRLLQSEFCLQALEVLDHIMTMTGTSMDKHHLRMSMTRSSSKAIKKEYERTQSLFGIPEESGWSIPVPAKHAETTRANVHAVFYMCQSAESLDTEPLPTPEVEFHVDDFQYGYFPPTERTETMMSDEGRGDGNIGDLVMKLDSLDDFFEDTLQSPTSDGRSSRTITEAGFAGEGFESGAIYDEQTLPILTQSFARTSSAASFANGFADPQRREPANAMNPGAFNIGSRPGMHSRSVTSPSTSAGFPTLNYLSDDDYPEEVFSDGDDDRAAATGEGSFFLENMIKPLAQGTRIGMRRLTGGRSRDNERHRDNLRAERRGMSQPPKSPRVPKVPSEYLTKVTSPGDVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3M4</accession>
    <name>A0A3D8S3M4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_05389</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3M4"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007344">
        <property type="entry name" value="GrpB/CoaE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34822">
        <property type="entry name" value="GRPB DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G01530)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34822:SF1">
        <property type="entry name" value="GRPB FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04229">
        <property type="entry name" value="GrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW80691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="277" mass="31120" checksum="60B7FB67A5574729" modified="2019-01-16" version="1">MTLRRDLPPGDSTKPRAAVSPSRLAFLRLATRSVRARSRDRSVSTDIALYPVTSLSSAPSSTIRLKSTTIIPTMPATVAQILAPCADNPELVERIASRTVEPSITILEPNPEWPQRFEEVKERIQKALGAFILEIAHTGSTSVPGLPAKDIIDVDLTLKDVTDEASYVKPLEAAGFRFILREPAWHQHRFFVENWPKAYHVNLHVWGSDSPEAARHLIFRDWLRKTPADLELYAKVKREAAEQTAVAGDSMMDYTQRKDNTIHEILGRAFRDLGYIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3N2</accession>
    <name>A0A3D8S3N2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Ribosome biogenesis protein NOP53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_05399</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">May play a role in ribosome biogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
            <location evidence="5">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the NOP53 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3N2"/>
    <dbReference type="OrthoDB" id="5072at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011687">
        <property type="entry name" value="Nop53/GLTSCR2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211">
        <property type="entry name" value="GLIOMA SUPPRESSOR CANDIDATE REGION GENE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14211:SF7">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07767">
        <property type="entry name" value="Nop53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017302">
        <property type="entry name" value="Gltscr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="95"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="237"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="237"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="283"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR017302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW80701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="439" mass="49913" checksum="C197AD495C01860E" modified="2019-01-16" version="1">MPILKPATVAPGAPQQHKQPSRKGKKAWRKNVDVTEIQEGLEEVRDEVIKGGVITEKESADLFTVDIAGDAAIQKKQLKGSKPLKADEILAQRSAVPAVSMRKRPGEDKTTDGVTKEKRQRTSYVSHKEFTRLRNIADGRQEKVVEVTEASYDPWDVQRDIEEQKQDPRFSFLEKKKKKVAPATLKEKPISMAASGKSIPAVQRPEGGYSYNPVFTEYEERLTAEGMRELEAEQKRLAAAEAERIRQEASAKSAAEAEAAERRAEMSEWEEDSAWEGLESGAEDVRLNAKRPERKTQVQRNKIKRRKEEERKAKMAAEIKKKDEQAAQVKQLAKEAAEKEQARALARIKDDSDGEGDDLELRRRKLGKIALPEKDLELVLPDELQESLRLLKPEGNLLKDRYRSLLVRGKVEARRPISFAKKRKVKATEKWTHKDFMLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3X1</accession>
    <name>A0A3D8S3X1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tuberous sclerosis 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_05663</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3X1"/>
    <dbReference type="OrthoDB" id="6022054at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007483">
        <property type="entry name" value="Hamartin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15154:SF2">
        <property type="entry name" value="HAMARTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04388">
        <property type="entry name" value="Hamartin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="290"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="431"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="498"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="561"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="671"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="896"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="955"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="754"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="565"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="594"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="960"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="993"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1021"/>
            <end position="1032"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW80965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1046" mass="117615" checksum="95035FD62BBE66A4" modified="2019-01-16" version="1">MSSGSLKDLTKALQSSIVNPTLPLPDDLVQVIDAYLDKHDSHDEADQQKLQEELLATYQKDVIDHPPRYAAFLAILRHLKRAIQGSGRLLQWWDRLAGPVLEQLGKEKGLPTEAHQTLLSILVYDEDDEELEDAKASCAILTENLLSSWLIKFVTATAGELDPEAQFVERKVKSILLEAGRKRPKDFLTVLNKFVVKKDSRIPALSLLVDFIEFQPPHLHQMLETPLFDNLLRCLQIDTSTRAISLAMTATIMFLPHVPSSLAKHLPSLFNIYSRMLFWDRYRRTGAEVLAPKEEKAEKTDDDTEDGTEQPTPEKKSDVEWEKLPYLLESDDEAVPELLHYFTFLYGLYPLNFMSYIRKPQRYLRHANFPWADELDVEPTEIRQRSETFRQLHLLHSNFFTMTIESELTDTNRWMKSQSADVVAECMALFSPGDGSAPDPPSRARNGEQLTKVRSNEDVPEQPLPDGEHMMPFPPRQPSWRNTTSTAVLLPNGARGFAGMYRRPSQTSFSLPSIPDSPSLRAKAQKDEEAIDSPTLAPLRGTPSPSQINIHSILDSQKTLRGEVQQTLASESAQSLASSTNNDDSNHADPCPQPLNSASVETSNGAATEAQMVIAYLHRELTLLKNDLSFERFLKQQHLSHIGQLRRQQIREARVEAETQNLINSNRALKSKLDEAKRSNLQMKRETEKSKSHSRKWEADLSAKLRVLKDEKKAWTSEGDQLKRDLTFAHTALFNMKQLIVNSESRELGSQQKLQSIESNMDELQRLRAEVDKLNLSVRQYEANESQTRRQKESAEAVQNEVELLKMKLASRDEELAKAKKAFEEELLASKSRVNDEAEAGRGQYASKMQLFLDEGLASSRSRIIELQKAHEHLLDRYTALQSSYLELMDSSSHDEPLLSGGISRARTDLGPLSRTSSPSGFNRLRQHTVSGTADYESSFASGSHFPVRPVRHTGETVASGSSDSRSLTSSHFQPFSPKSIKSNFAVEGDVGEDGKPKIKPQSDVRVFGRGGVQNIGKQPKKVDKKKEDGPSSKKGSGIRGIRGFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S980</accession>
    <name>A0A3D8S980_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Translational machinery component</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_04417</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW82926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S980"/>
    <dbReference type="OrthoDB" id="1618453at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.100:FF:000002">
        <property type="entry name" value="60S ribosomal protein L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_uL18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_uL18_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025607">
        <property type="entry name" value="Ribosomal_uL18_C_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="RIBOSOMAL PROTEIN L5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14204">
        <property type="entry name" value="Ribosomal_L18_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00058">
        <property type="entry name" value="RIBOSOMALL5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL18 C-terminal eukaryotes" evidence="6">
        <location>
            <begin position="245"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW82926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="306" mass="34855" checksum="B1EFF7550FE23B11" modified="2019-01-16" version="1">MPIADFGVYLAFHQAGKEHRYQTKYARRRAGKTDYYARKRLITQAKNKYNAPKYRLVIRFTNRDIVAQIVTSEITGDKVFCSAYAHELKAYGIEHGLTNWSSAYCVGLLIARRVLKKLGLDEDFTGVEEADGEFTLTEAAEGDDGEARRPFKAFLDVGLARTSTGARVFGAMKGASDGGILIPHSENRFPGYDIESKELDAETLRKYIFAGHIAEYMETLADDDEERYKSQFQGYIDDEIEADGLEELYQEAHKQIREDPFKKVEGAAEKKDKSEYKKESLKFRGRKLTKDEKVQRVKEKIAAARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S9J2</accession>
    <name>A0A3D8S9J2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">dipeptidyl-peptidase IV</fullName>
            <ecNumber evidence="5">3.4.14.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BP5796_04517</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a polypeptide, preferentially when Yaa is Pro, provided Zaa is neither Pro nor hydroxyproline.</text>
            <dbReference type="EC" id="3.4.14.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Vacuole membrane</location>
            <topology evidence="3">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase S9B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.5" evidence="5"/>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S9J2"/>
    <dbReference type="OrthoDB" id="16520at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000003">
        <property type="entry name" value="Dipeptidyl peptidase 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.140.10.30">
        <property type="entry name" value="Dipeptidylpeptidase IV, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002469">
        <property type="entry name" value="Peptidase_S9B_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050278">
        <property type="entry name" value="Serine_Prot_S9B/DPPIV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731:SF200">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 10, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11731">
        <property type="entry name" value="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00930">
        <property type="entry name" value="DPPIV_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 20" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="15" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="12" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="9 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="Dipeptidylpeptidase IV N-terminal" evidence="19">
        <location>
            <begin position="247"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="18">
        <location>
            <begin position="708"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="48"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RDW83026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="929" mass="103602" checksum="57F258D2DD26DE46" modified="2019-01-16" version="1">MARHNEEGAQLLPIDQEDSIRKSDDSLSSASTTSLVFERIGNRVAAAEEETAGIHGPGKKMVTPKFPPRGESRAYVDDEYAQSPLREEEKDYDDLETGPFLHNRDGADKGVDKKLRRLIWIIGGIFIGVWLFTIAVFLFRQTYRHASTTPHDPQATASRGNGKKITLEQVMTGQWRARKHDISWIEGANGEDGLLLETGQAGKPYLVVEDVRNDGGDASVHASKTLMEQASFRAGDRSLYPNRVTPSKDLKKVLVATDYQSNWRHSFVAKYWIFDVASQMAEPLDPASPDGNIQLASWSPQSDAVVFVRDNNLFLRKLASPTVTQITVDGGADLFYGIPDWVYEEEVFGGNSATWWAEDGKYLAFLRTNESAVPEYPIQYFVSRPSGETPAPGEENYPEVRQIKYPKAGAPNPTVDLLFYDVAKGDVFEVTATDGFAPDDLLITEVIWAGSTGKALIRETNRESDILRVVLVDVLTRTGKTVRKTNVQKLDGGWFEVSENTKYIPADPANGRPEDGYIDTVIHDGYDHIGYFTPMSNPNPVMLTSGNWEVVNAPSAIDLKNNLVYFVATKESSLQRHVYSVKVDGTGMQALTDISSEGFHSVSFSSGAAYALLTYEGPNIPWQKVISTPSSKESYENIIEENSGLADMAKKHELPLMIYSTVNVDGYELNVVERRPPHFNEKKKYPVLFYLYGGPGSQSVDKTFGVTFQEYIAASLGYIVVTVDGRGTGFTGRKSRVIIRGNLGYYEAKDQIATAKIWAQKKYVDASRLAIWGWSYGGFMTLKTLEQDAGQTFSYGMAVAPVTDWRFYDSIYTERYMHTPQHNPEGYANSSISNVTALQQNVRFLIMHGVADDNVHMQNSLTLLDKLDVAGVENYDVHVFPDSDHGIYFHNANKIVYDKLNNWLINAFNGEWLRTSNAVPLQIDTAKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S9T0</accession>
    <name>A0A3D8S9T0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_04597</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S9T0"/>
    <dbReference type="OrthoDB" id="5409186at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017636065" evidence="2">
        <location>
            <begin position="19"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW83106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="305" mass="31573" checksum="3F96060EB959095D" modified="2019-01-16" version="1">MQITNITRFSILFTAVLGSAAPKPYKLGSGAFNKALGLSRRYDQGYQPTQDTCGSGNTCAEACGMGYITCDSSVDEGSHCFNPDAGEKCCPNNSGDSCSKGYYCTEDTKHNTWCCPDGTDLASCAAAYSLTDALVSQTVAPTTVSSASAPYSTDVDDYETTASETCTESELYPTTAASASEPYPTDAETYPTTTSSDNDAYPTDDEAYPTTTPSDSDTYPTDDEIYTSSTTTTSVTSTYSKKGVTAAATMYTTTAYVTVCAASGTLAVKTTSANLVQFTGAANAKAVGYGGAPALLMAAGVALLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S9X5</accession>
    <name>A0A3D8S9X5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_04564</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S9X5"/>
    <dbReference type="OrthoDB" id="6262491at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001196">
        <property type="entry name" value="WD repeat protein (AFU_orthologue AFUA_1G12380)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF8">
        <property type="entry name" value="F-BOX AND WD REPEAT DOMAIN CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="314"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="363"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="363"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="380"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW83073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="395" mass="43432" checksum="456234700774E5C6" modified="2019-01-16" version="1">MSRSTDPGHFFQTDASESIRARKAAKSGNKNGEPIVLQSKVLSVEQDPFSSACVYVAESAGCVRKVNVETKDTKTVYRGPTAPVTSVAIGGRGGSIVFAGCWDKDIWSWDRESRAPGHRYKGHSDFVKAIICVKIGGKDCLISGGADCKIMVWDTANGERLYTLRDKSESMMAIQDLAVDPHESTETEVVLVSSSSDPSIRRWRVSLQAASQIIDSAEMTTSKDNPRSTILEHETSVYHVHFSGDDEDADLWTASADGTAKCLSRARGWATEDTYVHGDYVRAVAVTSNWVLTAGRNEDVKVWDRASGKLWHIYDGHYEEVTGLVVLPGETKVVSVSIDGTVRTWDLGKKELETARIEKEEKMKGVVKEKEEEKTSLLTAEEEAELAELMDSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAV4</accession>
    <name>A0A3D8SAV4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">U3 small nucleolar RNA-associated protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_04725</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the HEATR1/UTP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="31183at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012954">
        <property type="entry name" value="BP28_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056473">
        <property type="entry name" value="HEAT_Utp10/HEAT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022125">
        <property type="entry name" value="U3snoRNP10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040191">
        <property type="entry name" value="UTP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457">
        <property type="entry name" value="BAP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08146">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23243">
        <property type="entry name" value="HEAT_HEATR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12397">
        <property type="entry name" value="U3snoRNP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01036">
        <property type="entry name" value="BP28CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="6 10" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BP28 C-terminal" evidence="12">
        <location>
            <begin position="1522"/>
            <end position="1673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="687"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW83234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1803" mass="199128" checksum="F4B2F416135D86C2" modified="2019-01-16" version="1">MASILGAQLAQIAANSTNSLNLKAQKAAHSKSLIFEPRVAASQSFDTIYTICHEGFQELCLLDDRFREFQRTIFSEQSQEEDRTQMTAAENAELDRRLEAFMGLVGARLRLNPGVKAVEWLVRRFRVHEYNTSFLLATFLPYHTLPIFTAVLSILPANLAHEFRFLQPYIRSLSQPPRHAIVHATINNTSFALMLNSYVINVSKVRHHHQALLAFWAGIMTEATSGMLDKARSGRKGVQQQNEQDVIMGLLPTLNEALAMKKVPDLRIGCYMLLSVLASKGGLEDKILTAMMEAVALGWTTETTLPGLVCLSVLAQHRTARQLTKRLTKELLKVPNLANLLTEISQQQRVDKLAAQLCGGLMDRLVKSGDARGLSIVGEVIKYGLLADEQIERTVKALLLAALRIKDDTSEQTRSDFAALLVSLTQMPGHSGSVALRAISGNTEIDMDNLEMNLRASIRPRALEAASEDTPMEDANDVAIGTTSSFSELVQKLPARVENEVSFLAHKVSHVYSDLCRAFLASIITEADKDQFDGLPILQREELLSNSLYLTLYMRIWCGPYPVMARTSAVQMATRCLSKSIASRVDFQAVIPYAIAALNDPATRVRRAAAELLIELQRLYPDHAEGKKATKDIMVWAFDDIYGTGEETAQTKWLPVDVVSRLLRDVILPSLEECVLDKNHIESVLEKSLNGPRNSTDSPKKADSGRLPQAARASIMSFLASHAVNTPLMVTKLRLLKSLNQVRGVASTTRTKVLLPLLQQWADMNLSDATARLEEEQLDLAVYNDQALLVITATDKEGLNFLAAILSGEVATTRPDLLSAAFRRLRTMWTSLKGELRLHMAQRLMDTSQHGADGSSHQAKASEEASQFLNSVSLSTDILLSFLSQLPTAAKLSDSPPATKRRRTSHGEVAKTTLQDPAQLSAAIQKVTFVLQLVDGSNPAGHPELLGDLFNVLAELQHFKAQVSSELAYLQGLVLGSMVAIMQAHKCDPNMKLDRSTVRADLLVDCVQKTASPQVQNSALLLIASLAATAPELVLHSVMPIFTFMGSSVLRQNDEYSAHVINQTIQEVIPPLISSLRQEKGNPVTGAAELLLSFVAAYEHVPAHRRQGLFTSLVQTLGAEDFLFALEIMLVDKYGATDDIKNFIVEVSGAFGVEIQLQTAVKFLELVADVLKPKPSFSSILLSTNDDGLLDPQRIALQELSVLPHLLSQRRLVRQTGKVLERDDMDAARVRDLYATLLENLLAMAETLKGQKSLHNACGDVLESILGLLSTAEFVKSVESLLDRPDEALRRKILRSLEARIEKESPSDSSSRIAMLGFLPQLTAIIRESKDVFYKHTAVRCVDLISEKYGKKDLEAVAAAAETIAGDYCLGQSESRLRVMALLCLSSLVEILHEGIVPVLPVAIPKALDYISQNLRNDDDALKLHNAGYAFISSLVHHLPYMISGGVLDQFLTISNASAAAKLDDEASECRLQCLRLAAKQIDAKAMFSALDQDWSQAATAGPLALHEYLLVLSIAIEKHPKMVVTKHASVLSKIFLNAFDLRRQWISQTEPLSEEDMSEIESEVNDVAIKMIYKFNDATFRPIFANLVDWAASSLPKKDTAGRILRLQSIYSFMAIFFDNLKSIVTSYATYLLENAVDVLSTVDPKDKHSQELWSRVLLALVKCFQHDQDDFWQAPSHFGAIAPALCNQFLHASSLPLVQSLIPAIVELAAAADSQDHHKELNTSILKHMRSENASIRLAAVRCQQALTDRLGEEWLAMLPEMLPFISELQEDDDDVVEKETHRWIVKAEGVLGESLDSMLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SGD3</accession>
    <name>A0A3D8SGD3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_03732</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SGD3"/>
    <dbReference type="OrthoDB" id="3172332at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF4">
        <property type="entry name" value="HYPOTHETICAL CONSERVED PROTEIN (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="30"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW85407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="62509" checksum="3E1948DA0A2A4403" modified="2019-01-16" version="1">MQVRRPPRPRCRRCIKFEVECDGYATPTYESPNLVDDPTGKTLQRRQGPDPLASSQLTTSLFDAEEHQYFHYFCNSTVAELSGFFENRFWGRLILQTCHHEPAVRKAVVAIAALGKTKEEAQILAPGSPAPIDLSRAKKHHRFALRRYDAAVKLMRRELNHVGGHQIRRALVWSLLIYCFETYHGDHEIALEHAQAGLKLWLEWLEQQYPNLASSGRHQRNSSMPGLTPPAPCIVEDEIFQAFTRLDCEVMTYSDTRPQSSHLKLKSIGMADVRDMPPKFSTLREARKYWSLVESRAMHYIASSYERTDGPKQGHEPHFIFNSAEEIPENHLLEKDQLINDIHRWLAACEPILERASSDKESADRMGIIALIVHSKFRLVGLRVHVKPCREIAYDEHSDMLAQALELLRVGIDEWQQTNPQQSSRYTSDSGIVLNLFRCAMKCRVPKVRREAIALLKRVRCREGFWDSELCARAATWVVDTEEKGLQGDFVPLEWRISVTSLTCLMSCWEQESKKKQGTLEIKLAQAHCTSPLFSHTHEASKRNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SGT4</accession>
    <name>A0A3D8SGT4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA N(6)-methyladenine demethylase</fullName>
            <ecNumber evidence="2">1.14.11.53</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_03828</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an N(6)-methyladenosine in mRNA + 2-oxoglutarate + O2 = an adenosine in mRNA + formaldehyde + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:49520"/>
            <dbReference type="Rhea" id="RHEA-COMP:12414"/>
            <dbReference type="Rhea" id="RHEA-COMP:12417"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:16842"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74449"/>
            <dbReference type="EC" id="1.14.11.53"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:49521"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 1 Fe(2+) ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.11.53" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SGT4"/>
    <dbReference type="OrthoDB" id="6614653at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990931">
        <property type="term" value="F:mRNA N6-methyladenosine dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.590:FF:000014">
        <property type="entry name" value="Oxidoreductase, 2OG-Fe(II) oxygenase family family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004574">
        <property type="entry name" value="Alkb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16557:SF2">
        <property type="entry name" value="NUCLEIC ACID DIOXYGENASE ALKBH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="10">
        <location>
            <begin position="224"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR604574-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW85503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="353" mass="39988" checksum="F3525F2251F58F60" modified="2019-01-16" version="1">MASLNPHEAPPQDLKDLFKKYQKLKPDQYVHDEDLIRFGPLENVDSEAYDVSSPISTSQLQEAFGDFLHGEIGDIAFAECPIYSSRAVPGLVILPSLLPPPVQKELLSRLMHRDMSDPEHKTNLDFHHVIVRPQKDASVKSASSTREEHASFFSLPPFATESFLPKDPDVHKPYTTKQVLEKKMRWITLGGQYDWTRKEYPEEEPPDFPHDIARLVEILFPEMKAQAAIVNLYSPGDTLSLHRDVSEEVDRGLVSISLGCDCIFIIGLGPSSLAGGEHPSTNSRYLVLRLRSGDAVYMSKDARYAWHGVPKIIAGTCPAYLANWPAEMENEYESWRGWMSSKRINLNIRQMRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SH22</accession>
    <name>A0A3D8SH22_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Catabolite repression protein-like protein creC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_03974</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Required to prevent the proteolysis of the CreB deubiquitinating enzyme in the absence of carbon catabolite repression. CreB deubiquitinating enzyme stabilized in a complex with the CreC leads to the expression of genes such as those in the proline and quinate pathways.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Interacts with creB.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat creC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SH22"/>
    <dbReference type="OrthoDB" id="3367at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051286">
        <property type="term" value="C:cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045013">
        <property type="term" value="P:carbon catabolite repression of transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051362">
        <property type="entry name" value="WD_repeat_creC_regulators"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107:SF16">
        <property type="entry name" value="AT02583P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14107">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="418"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="107"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="521"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="521"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="533"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW85649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="613" mass="67097" checksum="FFD8870D56508F7B" modified="2019-01-16" version="1">MFVLPPPPRYPSQAAYNAAVAAGQAAPMIETNNILSHPTGPEFQLVVGEGTYVLKEDLHLATPPPHPSEAPIINPNPLATTPQPATAGTKVSLLSFSSKSSAPLLYRADTNRSNGGYTSIQEHPNEGRNSGDVPGSSDGGGTSISGSAKPAMSIGSAPAFGEGNSSLLSAGGKDAGKRRKPKNNIAKSNSSFISRCIVNESLTKRLQDRPSDGYFAFANINRAFQWLDLSSPQKADHLTKILFTKGHCLCHDINQVTKSPQHIDLIMGFSTGEIIWFEPISQKYTRLNKNGIINSTPVSEIRWIPGSENLFLTAHMDGSLVVYDKEKDDAVFLPEKNGSQTNGNSDSDGSLDISAKLHIDKSVHSANQKTNPVSFWKLSNQRINAFSFSPDNRHIAVVSEDGTLRIIDYLKEELLDLYTSYYGGFICVCWSPDGKYVLTGGQDDLVSIWSVSERVIVARCQGHHSWVTAVAFDPWRCDDRNYRFGSVGEDCRLLLWDFSVGMLRRPKASSARQRGSISSRFTNTLQRAETQNTTTSRLRSDSSLSADDDTEHTIEHPVEPRATTAMLPPVLSKAIEVDPLCWLEFTEESIITSCKTGHIRTWDRPKDAANVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHB4</accession>
    <name>A0A3D8SHB4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03869</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHB4"/>
    <dbReference type="OrthoDB" id="10355469at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="33"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW85544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="572" mass="63637" checksum="B1FD70DE929363B2" modified="2019-01-16" version="1">MPQMNESTTPSGEASRTSLPEGHHRGKKQKTTSRAAQASASSVAAASAQARVPPAAAPQSAGPSGASRSYEPPKKFSYENMPHPDTLLYLRKAEKARYKKHYDAFQTLFQFQREENPHSQSRYRPSGDEEMQRVLDRCIANGGPLTPKSSRLLATSFDHKSTCIQPYIDINRNRWLEAVAQGREIQPPLDVAARVNGTPSPTESDIEESVFDSEEDTITSADSREVANTDANNAQGSNYSGWTSVNTQEPVNLSYAGPARHVTTAHSPDLVSRPENGSNSGHANPRPSVRDAWADRNTQLMYPARAHDAHGEDIFSKEGAFSAFRRARFREAIVSPPARNDNEELERQPYITLPPIRDMQPHQPPVQHPSTFNGEAPNAHAQMNLMKEMYRRSINRRITDEQKLAAVAAKEAAGGRRDTAVRGGQASTRRVVQSEIWSFSPKKDGTNGFEDNISDEPPRNHAAPFSSASFEYPQPMERHIDITLPRMEIPLSPDFQSDQPRSKQFRAGTTAGLLQRPIIFDPQMEALKNKFMDYGHTELVQKAAKEQQNAQAELRKKEKFHANLVASGVARW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHC1</accession>
    <name>A0A3D8SHC1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_04070</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHC1"/>
    <dbReference type="OrthoDB" id="1630758at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001293">
        <property type="entry name" value="Znf_TRAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131">
        <property type="entry name" value="TNF RECEPTOR ASSOCIATED FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10131:SF94">
        <property type="entry name" value="TNF RECEPTOR-ASSOCIATED FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02176">
        <property type="entry name" value="zf-TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50145">
        <property type="entry name" value="ZF_TRAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="77"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="TRAF-type" evidence="8">
        <location>
            <begin position="208"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="TRAF-type" evidence="4">
        <location>
            <begin position="208"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="410"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="279"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="415"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="429"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW85745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="445" mass="49880" checksum="3F691C9BFC267229" modified="2019-01-16" version="1">MPPPNTPGGSPPDLSPLHITVPPNTPFNHGSPRSRRTRTARNPYSIDENKVYEIGPSDGVDLRCLKYVSEVDENLLCPICHAALVDPVTTPCDHTYCEDCIYTAWKSNPTCPVDRSPLILPGDVATPPKIVLNQLDALKVKCPCCGDTLPRSMLRNHLSRYCSNALVKCPDEVCEKLVKRKDEGKGCLHYDSECPDCKEHLQEIDMESHREVECENREGICQHCSETIIRCKEAEHLKSCPEVMTSCKWTKYGCQHGALRKELDAHANECRFSTVGQMAEMLQAEISTLRDQLHTLNEKDKAQERRIKFLETHPHFNFSDVSSQSVSRLPDSSPTAEFPESRDQYLLSLLESQESKVDQLSVGLTELEAKQTMMLFNETIPIKEQLAELRSAQGVIGMHVRWLMNFRMQERRPGPGAGGSSESGGPGGDGHRRLSDTMRDVITKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHS8</accession>
    <name>A0A3D8SHS8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_04178</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHS8"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF60">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="57"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW85853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="494" mass="54322" checksum="EDCD2E14E96012DE" modified="2019-01-16" version="1">MHSTSDEKSSEAVIAKPSDAQIREEELDGQAEILISWTSPTDPHNPHNWPSHRKWTITLLVSFGSLVTLMSGSVLAPAIPVMSKDLRITASEAQLALSIFVLAFSVGPIVLAPLSEIYGRRPIWLYGGIWYLIWNTVCGFADNKTLIIVGRLFAGLGAAGEYSVCQPILSDVWNPEERGKAYAISTFLPLLGPALGPIIGGVVTDKLGWPWLFFVISIFDGMLIIYALTMFHESYGPKILSQKAKAMNKRGDQEYTTEHDRAAPTISQQLSMGLTRPARLLATQPILQLMSLYLAYNFGILYIVLSTFATLWTERYHQPVSVSGLHYLALVIGYTIAAQVGGKVTDRVWAHLQKKAKAHAVPEYRVPLMIPGAVLLPIGLFWYGWAAEARIMWIVPDIGIMVFGCGIILGTQAMQAYVLDSCPRYTASAVAGAQLPRGFAAFAFPIFAPKMYSTLGYGWGNSLLAFTFMAIGLPAPLLLWKFGARLRARGKPQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SI33</accession>
    <name>A0A3D8SI33_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">DUF221-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_04340</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CSC1 (TC 1.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW86015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SI33"/>
    <dbReference type="OrthoDB" id="1076608at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005227">
        <property type="term" value="F:calcium-activated cation channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045122">
        <property type="entry name" value="Csc1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003864">
        <property type="entry name" value="CSC1/OSCA1-like_7TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027815">
        <property type="entry name" value="CSC1/OSCA1-like_cyt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032880">
        <property type="entry name" value="CSC1/OSCA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022257">
        <property type="entry name" value="PHM7_ext"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018">
        <property type="entry name" value="PROBABLE MEMBRANE PROTEIN DUF221-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13018:SF20">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14703">
        <property type="entry name" value="PHM7_cyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12621">
        <property type="entry name" value="PHM7_ext"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02714">
        <property type="entry name" value="RSN1_7TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13967">
        <property type="entry name" value="RSN1_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="466"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="511"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="560"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="608"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="664"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="717"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="753"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like N-terminal transmembrane" evidence="11">
        <location>
            <begin position="30"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like cytosolic" evidence="12">
        <location>
            <begin position="215"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="CSC1/OSCA1-like 7TM region" evidence="9">
        <location>
            <begin position="470"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="10TM putative phosphate transporter extracellular tail" evidence="10">
        <location>
            <begin position="940"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="283"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="802"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="807"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="819"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="865"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW86015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1027" mass="116083" checksum="E7F1F2713C2FC736" modified="2019-01-16" version="1">MSGISIILNGTINGDAGSAQGRQGTTITTFAISLAAGFILFTAQFGIFLVIRNYLWAKRIYQPRSFLVPAKQRIKPPYNNPFKWLLTVFKIKEDPEVLAKAGMDAYFFLRFLSMCLRIFTPMAIIIMPILIPLNVKHGKGINTINGVTYNVTGLDTLAWSNVSPENTNRYWAHLILAVGIVAWVCFIFHQELIHYIGKRQEFIGSLGHRLKASSTTVLIQDIPEALCNEDALEELYGDFPGGIRRIWINRDFTALVNKDKLRKYYEDLLENTETDLLRKVAKQSRRKKARQNGTLTQEAPEPVIRGVQPKEGGDLSPTRPKLGPPTPEACQHDLEYDLESQAAWTRFLTPKQRKTMRIPKDGHVAAAKIPLIGRFFTTKVDTIYYCRRELARLNKEFDIDVKTPDTYSKNLSAFVQFNSQKAAHLACQSVAYTTPRHMKRRMVEISPGDINWPSLNLSWRSRYLRLLGFLALFALLLFAFGLISFFTGILSRVSTLSGSTSWLTWVGNLPPWLLSFVQGTLPPIIQVIVLSGPLPILLRLMTNRTRGATTGQEGERSLQLWYFIFLLFELFIVPTISSGLTSIVDQLIRTPTSVPNILATNLPTASNYFFSFLIVQALSLSGTSILQTIRLFNFYVIGHVNTPDSVFQKLSWTNLTRIGSNIPWYTTFAVIGLVYSTIAPLILLFMLITFSLFWVVIKNNLLYCVRTGTVDGGGLFFPSAINQLFTGLYFMEFCLIGLFFLVRDAQNHVACEAQGIIMAMVLVFTVLYQIWLVNHLSPLFKYAPLRLELDSEALLAQHAEQLRTESHGSQQNSETSKVNPRDDEKDILEPSSHTAPPAQNIEIAPGSELSTHPRPAFYHRQSSHRSQELQAKQREDAKVADDILARLNRPLDEARLAQLEKKLARTGAGIGSALLPRYKDIEAQMLDDPISKIIMQHHDEMENLDPEERDMLISVAFMHPVLRETRPCVWIPEDDLGVSDDEVRRTRELSQDVVISNRGACFDRRLKVQVVKPPPDMSEFALIMAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SID1</accession>
    <name>A0A3D8SID1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_04357</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW86032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SID1"/>
    <dbReference type="OrthoDB" id="3598904at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF4">
        <property type="entry name" value="HYPOTHETICAL CONSERVED PROTEIN (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW86032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="494" mass="56042" checksum="3FAEC95C5AEFEC58" modified="2019-01-16" version="1">MPKVAKGRRQRAYHSKTQTGCLTCRKRRVKCDEAKPFCRKCTVGGRICDNRHYIRPLCPPQLDTISVLAGPSFDLAIYASPESRRSVAFFMQRTRHQQAGFFGSDFWERLVLQAAYHEPAIRHTIVAIGSLHELLERRSVIQDADKVFALEQYNLGMRYLLLPLSKNGERGVDNIQGNHASAGAHIRSGAKLLREISYDQRKGVIHHQVLGLKADKDSYVSLDVISRMYGRMCPDISLWIGAHDFERYEEFFSTETTEEVHPVFWSIEEAKNVFEYGRVLLLSNLSSLLPFNSVNSSTAAEPDSRHFETIMSRYSLVLQAYVRSRSLYFTREEDIAISVLRLNMLSSYLSVYMEHSPPHKKASWKDFMPHIMEMIELSEKIFSSTSTGTNQSSATCFCLDMGTVCPLYTLGSQCGDPTIRRKVIVLLRSSLRQEAFWNSFLAAEAIERIMKTEESVSSGTECLDDSHQVISLGIEPLKLDGKGGWAKQVLRGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SLT2</accession>
    <name>A0A3D8SLT2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-dependent hydrolase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_02971</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SLT2"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01298">
        <property type="entry name" value="ATZ_TRZ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050287">
        <property type="entry name" value="MTA/SAH_deaminase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794:SF11">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43794">
        <property type="entry name" value="AMINOHYDROLASE SSNA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="76"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW87277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="492" mass="52650" checksum="1F0F9D69593C898D" modified="2019-01-16" version="1">MDSSVSSAVPVPSAEKITLYCNATIITLNPTRDIILNGAIAIQGSRIIDVGKSSSISQKYQQHPQKVEVVDLASKIVIPGLVNTHSHLAQSLLRGLAEDLPLHSWLCDAIWPLEACYAADDGYVAARLTIAEMLKSGTTCFLESMLTHGSGFENVVRAVGESGIRGCLGKLVKFEESNTKLKISDPRDKDISSMSVASMLEAHRRHHGSFNDRLHVWAAAGTPRGSPLSSHRGIGEACREHDIGLTMHCAEAPKDLTIYRDMYSCSPVEFCQQAKLTGPKTVLAHMVNLDLDVDLPLLQESGTTVAHNPNSNCKLASGIAKVPQMLEAGVNVSLGTDGAPCGNTYDMFREMHLAGIIHKGANLDAALVGAEAVLEMATINGARALGLQDQIGSLEVGKKADFVVVDPGQLYSAPYDEAQILEGGLDPITTVVYSCTGADVEKVVVDGELLVDSGNLVKMDEKEIMEAAKSSIRGIRQRSGIKAAKKKGWNFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SM39</accession>
    <name>A0A3D8SM39_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_03064</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SM39"/>
    <dbReference type="OrthoDB" id="4074350at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017610670" description="Peptidase A1 domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="488"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="40"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW87370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="587" mass="62282" checksum="79074810A3B77D74" modified="2019-01-16" version="1">MAALIWSITVLYFLVDFSCAISPRAIEWSSKVYGPDGPWQAVSIAIGTPGQKIDLYPGGFFNSVIYASSLCATVCDAQVAGLYDPSASTTQFSFPEVPTLTNSFSSGVGGVNASFIFDNLNVLSTGSDPPAVVPSFDMQVWTAGFNVLPNGVKYPLEIGNLALGARDVNQTWQRGAGQPDINGTMLPSGLFAAGLVPSNSYGLHIGSVALSIPASLYIGGYDQTRVLGQVSTQPYGLNFLPIDLLDIGIGVAVGESPFGFSSRGDLLAKGNSTIGSALQVHVDSVAPYLNLPQSTCDALALDLPVTFQPDYNIYFWNTSDPLYEKIISSPSFLGFTFRLNNSISQNMTINAPFSLLNLTLTSPLVSEPTQYFPCYPITDSSPYILGKAFLQAAFVGVTWQTNDDGVWFLAQAPAPNTPTPSLGVVTTIGPADKFIVASDNSWIDTWSHTWTPIGTNTINIPTAGTTSLASSTGASSNTSARHGISNGAIAGVIVGTVSVLIALGLGCYFTKMKLRSRVRSSSSMQRAGVAASSLSQGSELENKWAADYGPWKTDGTTTKGAMELHNFYKRPRLSYSLARSGHFELEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SM72</accession>
    <name>A0A3D8SM72_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RNA-binding-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_02975</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SM72"/>
    <dbReference type="OrthoDB" id="267048at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12676">
        <property type="entry name" value="RRM3_Nop4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12677">
        <property type="entry name" value="RRM4_Nop4p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000406">
        <property type="entry name" value="Related to Nucleolar protein NOP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034809">
        <property type="entry name" value="Nop4_RRM4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034808">
        <property type="entry name" value="Nop4p_RRM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="40"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="157"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="359"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="538"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="118"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="242"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="577"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="696"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="119"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="306"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="577"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="696"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="729"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="771"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="795"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW87281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="809" mass="90532" checksum="F895FD8FE452D277" modified="2019-01-16" version="1">MSKRQRVQEDDGPATIVGDEDGPIHISKRARKETNASAKRSLFVRSLPATATSEALTELFSQSYPLKHATVVLDPVTKQSKGYGFVTFADADDAERAQEEFHGKKFQGRTMKVEIAQPRSRDAKPGTDGKKKSAIAEEAAKVKKERSEKMAEQRQPLKLIIRNLPWSVNTTEKLAELFSKFGKVKHSTLPKVKDTQKGFGFVVMRGRKNAEKALAAVNGTLVDGRVIAVDWAVEKDVWEGQKKAANDQSEADGSEEDGGAKVDKVDEKRADTSDYDEDEDLANFFKDRADVLESEDENEEAMKIDTEDEDEDEEDEDEEDDENENEEVSENSDDDLENDDEESEEEEKPVKNFITDNSSTLFVRNLPFTTLDADLKEHFNQFGPVRYARVVMDRATDRPKGTGFVCFFNVEDADNCFRGAPRYQPTGANAIAPQLKHSILQKEEADTSGMYTIEGRLLQISKAVEREQATKLTEVGQNQRTERDTDKRKLYLLSEGTIAKGSPLYEALAPSEVKMREDSAMQRKKLIQNNPTLHLSLTRLSIRNLPRNINSKDLKALAREAVVGFAKDVKNGVRAQLSKEEEARGGDEMRDAEKHRKAKGKGIVKQAKIVFEGREGSKVPEATGAGRSRGYGFLEYSSHRWALMGLRWLNGHSIESGSGKKQRLIVEFAIENVQVVSRRKEREEKARIRSKEVLEAREKGEAPEKEKKVLGKDTLMAKTRKGMKPGTKGPEKRGGPERRAPGGKGRPAPIKSKPLKGGRDKAGRPTHTPKGQREPKENADSGEKDGLAKRQQIIQKKRMMRRNRKNGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMA7</accession>
    <name>A0A3D8SMA7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Subtilisin-like serine protease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03134</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SMA7"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046536">
        <property type="entry name" value="DUF6601"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34414">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34414:SF1">
        <property type="entry name" value="SUBTILISIN-LIKE SERINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20246">
        <property type="entry name" value="DUF6601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW87440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="38340" checksum="F75B2A0DFF9DB1D5" modified="2019-01-16" version="1">MSSFRQPPFSEQDQLCHYLDQDGLNTSGNFGPAQMLPGVPYVQISNIHQVCDFLKTDLFSPDLEVMAPYLWMMSTESHSNINPLHRQRVKGREIILTEEPRLHLVWYYDRIFIKPLPEYLTSYNFWKIFLLSDSLSNPGPTTDTGTAKKDLCAAALGYLRTYSYLIRHKSDFNIARKAGLLSESMEWDQYCRFMSSIRNISDSQVSGRYRYGELRLSRLNFHAKFILRRFYFEQIHAQYAENFSRFYGPLLFIFAIISVALSAMQVELAVDQVSFTQWTFIWPVCRWISALGLISIVMLVLGLMLLLLFMLGSELIYSLKSHFQTDKRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMA9</accession>
    <name>A0A3D8SMA9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA recognition motif-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SMA9"/>
    <dbReference type="OrthoDB" id="5408296at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW87455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="481" mass="51653" checksum="1E9DF9EB442C46F7" modified="2019-01-16" version="1">MATRPGEDLAATLFADVHYYYGSPTAKPPHHRFDKGSYVYLFENATQRRARIEIANNAGTAEQDATTGYLDGTHIRYSYTHSCLVSVTVESIQNGQNPPLADPQEWHLPTYDPRNEKKYMYKLHTLDIYFWNKEDALQFVNGLRRVLSPFQIIIENEPRAPSPHTEPMSPVVQQLENVAITDPSYAHGQTRDSRTTSSFPGPPISATPSGSSNSTFPGPPISATPRSVEASNFAPLAYNPAAPAAPEAIKHREKTPPPEDGAANPLVAAAASDHGQTYGGPFQQPGLSSPPLQTSYFPGPPTAGFQSAFHQQLPSAGLQSPHGQLSSINTFSPPPSSIASNVSNPPSAQSHMSPSYQSTGNHVPVTQYANYPGSPGFAPPSATSSGIYSPGLPGPPSAPPAHMAPPGGFSNYTYGSTSGMSSTQPLVNDYSIHKQLYRPTESEAAVKYKEKKPPAGKLEAKANNVEKKVGGFLKKLEKKYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMJ0</accession>
    <name>A0A3D8SMJ0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03095</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SMJ0"/>
    <dbReference type="OrthoDB" id="5281682at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW87401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="581" mass="65296" checksum="C37415F06FF9284B" modified="2019-01-16" version="1">MFADTSPRDEESIQAPPLTLLTTASTPVTPGPSTPTATRSITLEQLKVSDIIPPTRPSSTPFPKQDLLEGDIQCSWRESGPILDDTNAIFAEPFPTISSELTLCNLPTEIHECILDHLFGVRASASARNNPSGGSKVLRGWNSALRHSRRREVSELALVSNTWRHLIQDRLYRHLKIKGTRDSINQATLYFAEHPHLCSYIKHIEFWFPVFQQKNFPSENSPRIPNSTPERSNLIRPLVHLGIEPANTITYQTPSNNCSLEEIFRFVQMTFGEACILTLEGGERKKPPMVQHFRSGTPEGSRLPTIDTIRTLVCKGQWNLIRSNQDFQTIADALPMLNEWHGSYAKPKSKAYLSMATILPHLPQNLTHLNICLEGDYRRESMCPSFFRKVGQQTHFCIQMARSVPTLEYLVYTGRVCHSFFDAAAQVSNSRTTRLKSVDLVVKNCCRPSMQWNDGSGITDIAFIAAFESLVTSGVRSLERLAALEFLRIRFIDLESQAPPLNPYFQMEKGTCTGIWSEQIINALTRVRPEARFLERSESLGDVGYDKDGRLLTGPSFLKYRPLSIKVSSYLALSPGGITIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMM1</accession>
    <name>A0A3D8SMM1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03267</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SMM1"/>
    <dbReference type="OrthoDB" id="5422320at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024526">
        <property type="entry name" value="DUF3807"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40642">
        <property type="entry name" value="YALI0F31295P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40642:SF1">
        <property type="entry name" value="YALI0F31295P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12720">
        <property type="entry name" value="DUF3807"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW87573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="188" mass="21233" checksum="5895FD296239AF30" modified="2019-01-16" version="1">MALEITPADLAAFHAKHFSSVSVTHFSANFLGPVEEEEYYDEEDDGLGYYDDGVKRTLTDEQIAMFRHSEIESLLREQRHAREARDDSEVREAGAEQKNDAMEDGAEHDDGGIFDTNAPVVSKQKKKKGRKGGQGKSFFKQNVKPDLRKRTWDKVDKGLDDLAYDDADGSATQDRSSAPQRRRISYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMP8</accession>
    <name>A0A3D8SMP8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="12">6.1.1.7</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Alanyl-tRNA synthetase</fullName>
            <shortName evidence="12">AlaRS</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">ALA1</name>
        <name evidence="15" type="ORF">BP5796_03246</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>tRNA(Ala) + L-alanine + ATP = L-alanyl-tRNA(Ala) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="12"/>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SMP8"/>
    <dbReference type="OrthoDB" id="2423964at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070143">
        <property type="term" value="P:mitochondrial alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00673">
        <property type="entry name" value="AlaRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.130:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000011">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059090">
        <property type="entry name" value="ALA1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003156">
        <property type="entry name" value="DHHA1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF9">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26023">
        <property type="entry name" value="ALA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02272">
        <property type="entry name" value="DHHA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 12 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 12" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="14">
        <location>
            <begin position="9"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="812"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="609"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="613"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="728"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="732"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDW87552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="965" mass="107153" checksum="D1E2A3F378D0A29F" modified="2019-01-16" version="1">MAGDLEQKWNGVAVRNEFLNFFKQKGHTIVPSSSVVPHNDPTLLFTNAGMNQFKPIFLGTVNKADPMYTLKRAVDTQKCIRAGGKHNDLDDVGKDSYHHTFFEMLGNWSFGDYFKKGAIEMSWELLTVVFAIPADRLYVTYFEGDAASGLEPDLEAKKLWQSVGVADDHILPGNMKDNFWEMGETGPCGPCSEIHYDRIGGRNAAHLVNMDDPDVLEIWNNVFIQFDRQQDRSLKVLPAQHVDTGMGFERLVSVLQNKRTNYATDIFTPLFDKIKEVADKQNGGKFVVPAYTDKYGSDDPELMDTTYRVLADHIRLLSFAIADGGIPNNEGRGYVVRRVLRRGSRYAATYFKVELGKFFSSVLPALVEQMGAQFPELKDKQAEIAEILDEEETAFKSTLANGLKLFEKLADKARKDGSNKISGESVWRLYDTYGYPIDLTQILCDEANITFDEAEVTEAQDKAREASKSAKKQGDTFPKLDVHHIAELNKLNISTTKDDSKFTKDNTKGKIQTIFHNSEFLETTKGLPESSRIGIVLDKTNFYAEQGGQVADVGKLTVGDDAAFTVLDVQTYGGFIIHNGYLSYGNVSKGDEVECEFDELRRAPIRNNHTGTHVLNHALREHLGDDIMQKGSLVDEDKLRFDFSHKKAVSNDEIKKIEDSSNKYISSNSKVYAKEVDLTKAHEINGVRAVFGENYPDPVRVISVGVDVDTLLADPKNPEWLKYSVEFCGGTHVSDTGLIKELIVVEESGIAKGIRRVVAFTGAKAREAQRVASEFEARIKSLETMEFGPQKELEMKAAQNELLSSQISTLAKEDLKKRLAEVTKSILNEQKARQKAEVKAAIDNVTSFFAKPENKDKKFYVGRATESADAKVVAEVLNHFKKKEQDKSCVVFCGGSEGAVSHGTYVGKNAPTGVKAEEWAGLVSSIVGGSSGGKEPTRVGQGTDAAKIDEAVAKATQWFEEKLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SND6</accession>
    <name>A0A3D8SND6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SND6"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF6">
        <property type="entry name" value="OXIDASE USTYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW87843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="201" mass="23111" checksum="32B8A885503934A3" modified="2019-01-16" version="1">MARGHPDLVLHIFDTKYLAHTDGLSRARTVIRELYAPSAYNSPNETEAAAAWDTIRVGHGIVALDEQYIAENHLPKSFAHPYHPTKHAYVIEAYHAIHCITILRQHYQALDQGKPWDWPRGHDLHCFNVLCEYIMCNIDDTPLNFTHDRDSGHRLKKKCQDWDALSHWAGEHSSGYHFHEPNGSLRGPWLEDYTPGDGLVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXB5</accession>
    <name>A0A3D8SXB5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_02127</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW90962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SXB5"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF3">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="19"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="350"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="355"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="366"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW90962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="635" mass="70443" checksum="63759BBBF569D751" modified="2019-01-16" version="1">MASSRNGGDRTVGAKSTQACASCHFRKIKCDLMFLGKPPCTRCTTSNISCNRLTRRRRIIRAVEAISSVDGASTSLDEVAILFGSLGTGDSPRKLKVPGFGDISKQSSILVDFLSQDFSVGAINDYQVTFNDNYTSITRILANEFGRGFEEDIYHYRDAPFVERTQGGIPRNTSSSERAVLDLHGSFILPSPEISNSFVLAFFDRVHPTLPIIDRSSFLRNYYSISTDASNISLLLVQSILLSGSTTFESPGLNSAPEEVSWKLYTRTKALIENRFEQDRLTLVQSHLLISTFASDSCDDTIQNMWLSLGSAVRVAQGKRMQMIRCVASGNESGGPYLFTITSKKDGDDRVPFSDVNNSKSNLADSDVEELDEADFQPDEPGSLPTSEHTHFFLELCKLCFIISEWLDLLRPGGVRNPKQSKLQREMQAASLFIDLQQWHENIPAALRAPEDCKKFSLWNATLQITYHAALLRFSARVPEFQDTTDIAAAQISLICEDLDNQGLLGSLWGFGIHELDLAMAQHARSSNSTDTLVALEGLENLRKGLPWLRRLCKRSSVASQGLMFYAELVARFDKRGTGQLQVSSLDVDISETQHGFDTNYECEIGIGVQPILDTAGLDTSEAWGWEDYPSQFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXN1</accession>
    <name>A0A3D8SXN1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit G</fullName>
            <shortName evidence="5">eIF3g</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 RNA-binding subunit</fullName>
            <shortName evidence="5">eIF-3 RNA-binding subunit</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Translation initiation factor eIF3 p33 subunit homolog</fullName>
            <shortName evidence="5">eIF3 p33 homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">TIF35</name>
        <name evidence="9" type="ORF">BP5796_02231</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit G family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SXN1"/>
    <dbReference type="OrthoDB" id="639027at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12933">
        <property type="entry name" value="eIF3G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12408">
        <property type="entry name" value="RRM_eIF3G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000328">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03006">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017334">
        <property type="entry name" value="eIF3_g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024675">
        <property type="entry name" value="eIF3g_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034240">
        <property type="entry name" value="eIF3G_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12353">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037949">
        <property type="entry name" value="Transl_init_eIF-3_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="267"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="138"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="165"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="248"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW91066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="347" mass="38214" checksum="931909CED7CDCCA8" modified="2019-01-16" version="1">MFELATPSPNSKSRYPAVANNRGPTNIYNFERHDIRTTTTPQLLPHTHTSTSPEPLFKMSKAAGRADWADDEDLDDNVNALPPDTTTTNKDGTKTIITYRFNDEGKKVKTTRRIRFTTVKEVVNPRVAERKSWSKFGLSGKDAPGPASDTTSVGENIIFRPSANWKKDQKEEKPEAGSMKDKLKDKKVKCRICNGEHFTARCPFKDTMAPVGEEGSADVAAGPGDEPASVAGGLGAGKSSYVPPHLRNGGGGGEKMGGGKFERDDLATLRVTNVSEMAEEQELRDMFERFGRVTRVFLAKDRETGLAKGFAFISFQERTDAAKACEKMDGYGFKHLILRVEFAKKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXQ5</accession>
    <name>A0A3D8SXQ5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">P-type Na(+) transporter</fullName>
            <ecNumber evidence="20">7.2.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">BP5796_02282</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>K(+)(in) + ATP + H2O = K(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:75815"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="22">
            <dbReference type="Rhea" id="RHEA:14634"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="19">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IID subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.3" evidence="20"/>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SXQ5"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008554">
        <property type="term" value="F:P-type sodium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006816">
        <property type="term" value="P:calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006813">
        <property type="term" value="P:potassium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000028">
        <property type="entry name" value="Calcium-transporting P-type ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000001">
        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000160">
        <property type="entry name" value="Sarcoplasmic/endoplasmic reticulum calcium ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000015">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000020">
        <property type="entry name" value="Sodium ion P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006414">
        <property type="entry name" value="P-type_ATPase_IID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01523">
        <property type="entry name" value="ATPase-IID_K-Na"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00120">
        <property type="entry name" value="HATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="16" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17 24" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0915">Sodium</keyword>
    <keyword evidence="18" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="13" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 24" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14 24" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="797"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="834"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="880"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="920"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="973"/>
            <end position="993"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="24">
        <location>
            <begin position="1005"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="25">
        <location>
            <begin position="63"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00035017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00035029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="RDW91117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1054" mass="113726" checksum="9676ADD44E9C30D7" modified="2019-01-16" version="1">MKPVDSLSAEANPGSKDPLPRPLSQSQIDGKEQIYAHGTTATNSVVSSFPAEAGDEWGDVAQVAHVLDVDYISQKLNVDVQYGLRTEDAIYRLGRDGPNRLRGHEGTSVWRILMRQVSNSLTLVLVIAMALSYGINDYIEGAVITAVIFLNIVVGFFQDYRAEETMQSLKALSAPVCKVVRDRGHVQSLKAEDLVTGDIVQLATGDIIPADLRLFHGLNLETNEALLTGESLPIVKTPLAIMDSKDLSPGDRTNMAFSASTVTKGRGAGIVIATGTKTEVGQISELLNGGPAVTKSSNFVVRAFQNLKHALKNTLGLVGTPLQVKLSWFALLLLSLAILLAIIVFSVNKFNVSGEVLLYGVCVAVAIIPESLIAVLTITMSVGTKAMAKQNVVVRKLQAIEAVGGVTNICSDKTGTLTQGKMVVRRVWIPGCGMITVSDTRDILDPTTGSVALNEQKIDPGTVEKNVGLLECLNAVSLCNLATIYEPKPGISSSEKELSRWTAVGDPTEIALQVFAMRFDHGKSRLLLPRNLNLVAEHPFDSSIKRMSVAYEDSTHGTTHVYAKGALESLLPILSASDNQKAAISTQAETLAKDGLRVLCIAYKSVPNDQVETLTSRKMAEKDLVFLGLVGVYDPPRPGALESVKKCHNAGITVHMLTGDHISTATAIAREVGIIPTCMSAAPGTTTVITASVFDAMSDAEIDALPELPLVIARCSPTTKVSMVSALHRRQKYVSMTGDGVNDAPALKRADVGIAMGLNGSDVAKDCADMVLTDDDFSSIVRAIGEGRRLFDNIQKFLLHLLISNISQVVLLLVGLAFRDTENHSVFPLSPLEILWVNMITSSFLALGLGMEAASPDLMSRPPHSLRIGVFTKELIIDKMVYGCTMGVLCLVAFISVVYGKGDGNLGQNCNEGYNDTCYTVYRARATVFSVLSCLLLVTAWEVKHFSRSLFNLYPSKYTGPLNVWPAVRENRFLFWAVVGGLVTTFPVVYIPIVNRVVFKHLGIGWEWGVVIGCVMVYLGVLEAWKAGKRRFGLGSNANIVLRKEAITREGETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYK8</accession>
    <name>A0A3D8SYK8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative spindle assembly checkpoint protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_02539</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYK8"/>
    <dbReference type="OrthoDB" id="1806at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033597">
        <property type="term" value="C:mitotic checkpoint complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.900.10:FF:000002">
        <property type="entry name" value="Mitotic spindle assembly checkpoint protein MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045091">
        <property type="entry name" value="Mad2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11842:SF11">
        <property type="entry name" value="MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="8">
        <location>
            <begin position="18"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="121"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="131"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW91374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="228" mass="25472" checksum="05F7E30A8D6588D6" modified="2019-01-16" version="1">MSGEKDKDKSKVHKLSLKGSSKLVAEFFNYSINTILFQRGVYPAEDFSAVKKYGLTMLVSSDDQVKAYIKKIMSQLDKWMVGGKISKLVVVITDKETGEHVERWQFDVQIFNKSSKSKSSKRSVAEKENAAPDAAAAPAAQPEKTEKEIQDEIQSIFRQITASVTFLPQLDGDCTFNVLVYADADSDVPMEWGDSDAKEIVNGEKVQLRSFSTSNHRVDTLVSYRLAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYX4</accession>
    <name>A0A3D8SYX4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.256</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Asparagine-linked glycosylation protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BP5796_02133</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. In the lumen of the endoplasmic reticulum, adds the third and last glucose residue from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide intermediate Glc(2)Man(9)GlcNAc(2)-PP-Dol to produce Glc(3)Man(9)GlcNAc(2)-PP-Dol.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>an alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = a alpha-D-Glc-(1-&gt;2)-alpha-D-Glc-(1-&gt;3)-alpha-D-Glc-(1-&gt;3)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;6)]-alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29543"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="Rhea" id="RHEA-COMP:19512"/>
            <dbReference type="Rhea" id="RHEA-COMP:19522"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:132522"/>
            <dbReference type="ChEBI" id="CHEBI:132523"/>
            <dbReference type="EC" id="2.4.1.256"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:29544"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ALG10 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.256" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW90968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYX4"/>
    <dbReference type="OrthoDB" id="4769at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106073">
        <property type="term" value="F:dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016900">
        <property type="entry name" value="Alg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12989">
        <property type="entry name" value="ALPHA-1,2-GLUCOSYLTRANSFERASE ALG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12989:SF10">
        <property type="entry name" value="DOL-P-GLC:GLC(2)MAN(9)GLCNAC(2)-PP-DOL ALPHA-1,2-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04922">
        <property type="entry name" value="DIE2_ALG10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="409"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="461"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="522"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="579"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="495"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDW90968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="616" mass="67861" checksum="B0284DE87E089CC2" modified="2019-01-16" version="1">MTTSWNPISWLSGTTLLEESHAPPAAATSPIPKSKKILIALIYGSIIAPAWFWVSQVTKQVPEPYLDEVFHIPQAQAYCDGKYGVWDPKLTTPPGLYGFATLFAKLVGGGVCNVYTLRLFNTVVLLLAMAYASACRDLISRLSSTAQPFAITRAWLNSHAFISLDTVHTAVNIALFPPLFFFSGLFYTDILSTAVVLCMYMAFLRRPGAYENSAAGSIRLYVIGLVALTMRQTNIFWVAVFMGGLEAVRTVKAISGASSTGPSKVPGSMEELVAAVERYKIGQIHDVELSQADIPGKTFANLNFVLCIVSIAVAILYNPVLVLTRSWPYIALLVSFASFVIWNGGVVLGDKSNHVATIHLPQLLYLSAFTAFFSFPLLLPSALDLLPGFITARLPNFVQPPSTPSPNSIIKRALNVSILALCLLVTLATIRVNTIIHPFTLADNRHYVFYVFRYTILRHPLFRYLLAPVYLLSGWLAFQTLAGFPAPAYSPSAGERSQVSKAPNTHTAAPQRDAAPRGPTTSFLLIFTLATALSLITAPLVEPRYFIVPWVLWRVQLPSLPAREKGNAAGGGRSRDYRLYLETVWFLAINAVTGYIFLYKGFTWVQEEGKVQRFMW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYY9</accession>
    <name>A0A3D8SYY9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYY9"/>
    <dbReference type="OrthoDB" id="3180714at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10540">
        <property type="entry name" value="SET_SpSet7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="21"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="178" mass="19921" checksum="D4EA77CEC122EA75" modified="2019-01-16" version="1">MGSLAAVDVDRVEGVPLLRAPGLLLVMDTPKGRGVFAGRYIPAHTLLEVCPVLVLDPVENEQHVRKTDLYNYTYNWPYTPPQPTDGSTNQDTKTPTTTQAVILGLGSMFNHSTMRQNVGWRRDVKNLLMTYMTLRDVREGEELCISYGSRLTFRDTDAEELASGDEDENEMLGKIDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZA5</accession>
    <name>A0A3D8SZA5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="8">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_02822</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="8"/>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZA5"/>
    <dbReference type="OrthoDB" id="4699125at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DAHP_synth_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009395">
        <property type="entry name" value="PRK12755.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225:SF12">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, TYROSINE-INHIBITED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP synthetase I/KDSA" evidence="9">
        <location>
            <begin position="45"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW91657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="391" mass="42002" checksum="097E1991204C3CA3" modified="2019-01-16" version="1">MNLHEPLLLPSSGAKLALPLDETTQQNVLWGRDAVRNLLTQPHSDGRLLVVIGPCSIHDPDAALDYASRLIEATKQHHRELLIVMRVYVEKPRSTVGWKGLIHDPDYAQTLGNSDPDLNKGVLISRQIMLDIAKKGLPVATELLNPLLVHFFQDIVSVGVVGARTTESQTHREMSSDMPMPMGFKNGMDGGLQVAIDAMTASSRSHTVVGVDDEGRLAYHLSRGNPDTFVILRGGSNGPNFGPEHVKQAAQELVRVGKKPGIVVDCSHGNSMKDYRNQGSVAACLATQIAAGGPIMGVMLESNINEGRQDVPNKAAEAGLEYGVSITDGCVGWHETELILDCLAAAVRERQARSAVVGSISNTVAAADLEDEKHPVGVPASDITFALPVRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0X6</accession>
    <name>A0A3D8T0X6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_01619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0X6"/>
    <dbReference type="OrthoDB" id="3535300at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW92225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="569" mass="64254" checksum="5F693726B10FAA78" modified="2019-01-16" version="1">MTSMESPATVLAPLTMSQTKKELLTHLNMDPKTYVLMASEAGHVYKWLTSDVQHIKKYCKRNSPYSWNDMSEKSKDDAIERISGGGDLLTSYYWKLATPTEDCSNWIARWFLYQKFRFRDERNHTKVRRRLINSGISGSDKHNSMVFSSSRIAESDVGFRNQGIPEYQGVGRSSYGKVMFDPRQPPMEEVAGISSRPSGANTERKDHSPVIVDTLSAKTNSTVSDTCFGIPAFQVPQRRTTEVQKILQWPAVQTLLQSEGVDVSRWQGDSRGTEGWLIEVTRAFGNALPLDRPMDISYDETGELDLDRGCIMLNKTYIEGLCEAYFQSFHCICPILDQELFYLVTLPRVLRHSFSEVQEGSSLVLLVLALGCITRENNTGTPILNAGRDTGIRGTPERPPGLTFLNEAKRRFGISLTDWSITNLETYILCSIYYAQISRNMEYWRMSLLSLSANGGQYIAIGFQGVIGYVLFLKGELGLDLPGITALQDSVPLPVFLSDKIVPKGEPEHELFVEYHFLAQITLKSLINRARLSNQESSKAPLVRNTLYVEYILTMAESEHYYTKVRNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T110</accession>
    <name>A0A3D8T110_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mob1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_01505</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T110"/>
    <dbReference type="OrthoDB" id="10262609at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="398"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="456"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW92111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="485" mass="53600" checksum="40AA4C006976CA92" modified="2019-01-16" version="1">MASTPVSTEGIGSDGVPRTTPRLPSPPPPTEIQIGARSPSLGNFSNTQDTSIEQAISDANASRRIHPGTKSADMAAGPPLIPLSELDSAFQLQEHLKALHFYYSKPSSSTHTIPISRETASLITTQPEGIDRALWLYELCRFLINKCNDLIIGFLFDDPPCSATTCPEMRASEWQFLCAVHDSPKSCCAIDYCCHTLDWATNIVTSQKIFPSRLSLGAGDAVDDRGAGIKHLVNIFRRLHRIFAHAWFQHREVFWAVESQTGLYVLFKTVCDEYELLPAENYKLPPEAEGLDPVEESKSHISSIYRSEPSKSNPVTSIEEDFMGVGRTNTRRHIRQSPSVGSAVTTVLESDEEDHQGDVTQKLGKLHLAEEEEHEDDTTEVPVIVETYEVDNLEAEGIEDRLETQPTVEPKSCHEQGSTEAMPESIIEETEEGLERPAVESGDESTRAEPAVDGAIADKSKQDLPRESISEKFTDIQKTAQIKEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1U8</accession>
    <name>A0A3D8T1U8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_01936</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1U8"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07216">
        <property type="entry name" value="Pat17_PNPLA8_PNPLA9_like3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF6">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00381">
        <property type="entry name" value="KINESINLIGHT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PNPLA" evidence="4">
        <location>
            <begin position="21"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="833"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="3">
        <location>
            <begin position="25"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="3">
        <location>
            <begin position="75"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="3">
        <location>
            <begin position="222"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="3">
        <location>
            <position position="77"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW92542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1023" mass="115686" checksum="686521749006DD88" modified="2019-01-16" version="1">MSTKHSSAEPDPLDVTGLCLLSLDGGGVRGLSTLFILKGIMDRLNHERKILHQEQQMTADFEALKPCDVFDLIGGTSTGGLIAIMLGRLEMDVDQCITAYSDLAAVVFGEKLNRMPFNIQAQVQPRFDSAKLKTTVQKVIAESKVAQNDASETELLNDKIERGCKTFVCTVDRDTKNITRLRSYSLPEERNIPATIWQAALATSAATTFFEPVTIGHRTFTDGGLGANNPVDEVEDEASNIWCKETADLKPLVKCFISIGTGNPGKDAFKDNILNFLGQTVVAIATETENTEKKFIARWRKHFDEQRYFRFNVEQGLQDIGLDEHGKIGKIEAATEEYLAHTAQKFRVRDCIRNLSLKQSRAQTNLLSIINEFNERRIVDLHNVSRNESLWIVPFQQNPQFVGRSSELDKANAMLSSKTRCERVAFYGLGGVGKTQIALEFIYQVRVREPDCSVFWIPVTDIESMLEAYLEIAKQLQIPNIEKTEADVLQLVQQRLNQEDSGKWLLVFDNADDINIWTDKANDGTGRRISYLPKSKHGSIIFTTRSREAAVKLAGKNVVPIYEMNDAMAKDLLEKHLIDSDLLTDGKATKDVLQKLTYLPLAIVQAVAYININRITLLEYAKLLDDTEQNIVDILSTEFEDEGRYDNINNPVATTWLVSFEQIQTRNPLAAEYLSFMSCVNANDIPESLLPPGLSRKNEIDAIGILDAYSFISKRSADKAIDMHQLVHLVTRNWLQEQNLLAQWTERTVSRLNDILQESSDQNRSVWRRYLVHAYYTLESDLVSKDWGERINLVRKVGMCLGREGRFNEAGVLMAEVMEIDKKVLGNENPQTLTSMNDLAYLFFRQGKYDEAEPIYRQTLQLRAKVLGDEHPDTLGSRHNLALLLKSQGKYDEAEPIYRQTLQLSAKVLGEEHPDTLTSRNNLALLFYYQGKYDEAEPIYRQTLQLSAKVLGDEHPDTLGSRNNLAGLLESQGKYDEAEPIYRQTLQLRAKVLGEEHPDTLQSRNNLAGLFHRQGKYDEAEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1W5</accession>
    <name>A0A3D8T1W5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Signal peptide peptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_01914</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A22B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1W5"/>
    <dbReference type="OrthoDB" id="29661at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF23">
        <property type="entry name" value="MINOR HISTOCOMPATIBILITY ANTIGEN H13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="234"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="327"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="444"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="479"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="483"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW92520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="540" mass="59771" checksum="037C8A1E740091A4" modified="2019-01-16" version="1">MEGDSTVLQFLGKWSQKIYEERDLVQMYLHIFAAALFPIYIGSHASLRRPPSAQSPKKAIRSRNQDEDDDDIHVEEATVEGLTPSDAIMFPVLAGCTLGGLYLIIKWLEDPALLNKILGYYFSALGIFGVGKLVGDGLNVLTTFIFPDLWSYGNQTYHVDPLLSQQLTGGVKPGRVQVHRKFVADKMTPLPGYLSTIKFSEKNTQRLWALRALLKNHWIFRGYVHGILSMKGKVQLNDVIGLMIGFFAVVLYNTLGKTWWLTNLLGFGFCYGTLQLMSPTTFWTGSLVLAGLFIYDITMVFYTPLMVTVATSLDVPIKLVFPGKKGGMLGLGDVVLPGIMIALALRFDLYLHYLRKRTSPTPIVLNPDSSLTSATPPKITKALYKSATGNWGERFWTMSATPEDKASVGSRFPRVYFNAALVGYVAGMVATLVVLNIFNHAQPALLYLVPGVLIALWSTAAARGELNLMWNYTEDGSLDDGAEEKGEKKGGREEKKEVGTPEVLKTEKDAKEKAKRKSDEAHHVLLFSLSSPKSAKTALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T6X1</accession>
    <name>A0A3D8T6X1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_00027</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T6X1"/>
    <dbReference type="OrthoDB" id="74545at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37015">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37015:SF1">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW94264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="885" mass="102889" checksum="98DC6CDA984F0632" modified="2019-01-16" version="1">MSTAALSQTLKSITILKLKELEKQRRAYELRKAETLRYANLPDVDQRQRVYHLLLAVEQLDPAPASDIDLCNIRRWLDQSNFDTSVPDTMVDEFERQLRSQLDIQTRRLDLANLYSQLLTEWLNPISVDESVTVADDSSLDGSFELVEKDRLKQLVEKFEDVVFSPLEIDEVAIHNYLAALFEDDDAKAPLGRLRSQVKSQCDFRLRRKSPFDETTIRWCLKGLLGNDLLSDEKKVILQDFLTDEVARSEICDVLNMKYRDIKNWTWDAESGMPVQPRRQLNGKYRIMMDEDVLQAIFLHYIGMSWSSWMKKTLSDTILCKSIWKHKMVVPPKGTDRRRYYLGEYEGRNKLGIEEVRHTIYKTDFFLSQLPSSVYEGAGGYDDDQELSDDNTEDRKSPKEIKQQLLRQLASEMHFRLAMEGEFAVVQSDFQWFGTSISHTTISAVLRFIGMSEEWIAFFRKFLEAPLNMAPVSDKSGSSRARIRKRGVPMAHALEKFFGELVLLFMDFSVNQRAEMLLYRFHDDLWLCGQPEKCAKAWNIMEEFSAVMGLEFNRKKTGSVYITKDSTGGTKTRRFTDELPEGPVSVGLLELHSSGEWMIDQVQVDAHVAQLQKQLSQCESILSWVQTWNSCIGRFFSHTFGEPAHCFGRSHVDRILETYRKMQETLFQGSNVTTHLKTLMKERFRNEDIPDAFIYLPEQLGGLGLLNPFISPFLFRDTVFASPDANLRKAITQSRTNYNKAKREFECLSKQERQRRLRKIYPGEFDTANITDAKLDRFFSYEEFVQYDESINPELAYAYRELMTSPHKEDIVLSRRIFEALNSIAVMQPELNQSTLSSETKWILMFYERELFEHCGGLSIIEKNLLPLGILKILRKRRVAWQMVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T6Y2</accession>
    <name>A0A3D8T6Y2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_00115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T6Y2"/>
    <dbReference type="OrthoDB" id="274752at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019711">
        <property type="entry name" value="ATP_synth_F0_suH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28207">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT H, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28207:SF1">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT H, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10775">
        <property type="entry name" value="ATP_sub_h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW94352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="121" mass="13485" checksum="DC659B52AAA17DE3" modified="2019-01-16" version="1">MLAQSLRASRSSIARVARQQITKRTFIVPTAVRRADLVQDLYIRELKAYKLPAVKPTDAEGHVQIFSPPKAPKSPEETDIANELKAYETSTVEVEGQAEGGAAPVEESWFEEEPEEDEAHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7D8</accession>
    <name>A0A3D8T7D8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_00114</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7D8"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051414">
        <property type="entry name" value="Adenylate-forming_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439:SF2">
        <property type="entry name" value="ENZYME, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43439">
        <property type="entry name" value="PHENYLACETATE-COENZYME A LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW94351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="434" mass="47934" checksum="AC3210B138CF171B" modified="2019-01-16" version="1">MSLADLLAEEPVDHYAYDVPFEHVPDVPLVTFHSSGTSGDPKPINWSRSFISTLDCGHCLPAGQGIPVLESLNQLQNLLVVLPQFHAFGLGFAVFAAFYEMTIVLGHPDVWFSPEHISGLLQLGQVTSFFGPPSLLEDVSKMPQGIEGLSALEHVCYAGGPSRPDVGDSLAPKLKHLHAQLGATEWGYAHLACGPSKCWSAMKFFQDVGYRFDKVAENIFEIVMVNDPMTNKYHGTFEVFPQLKEYRTKDLWSPVPDLPSGWLRYQGRANDLMALSNGEKVNSIPMENTIQAHPIIKAALIIGQYRFNPSLLMQTEDDCVPQNQLQSEAILHQIWPTIQEANSKAPGFAKIPKSLVLFARPDKPFLLAGKGTVQRQNTIKLYAAELDELYHSAEMGVLVEGLTIEKPVNLLGPLKIAGECTIPSSRNSITDFER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7E3</accession>
    <name>A0A3D8T7E3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldo reductase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_00197</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7E3"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="5">
        <location>
            <begin position="26"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="4">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW94434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="319" mass="36019" checksum="5BA9EC61FBB8E8F4" modified="2019-01-16" version="1">MTGKPTIKLNNGNIMPALGFGTFAEPLLPGTTRVAVKAALQAGWRHLDCAWIYANEDEVGAGLKEFLEENPEIKRSDIFITTKVWPHLFEPADVEWSLNDSLKKLGISETDLLLLHWPFSAERTADYQIKRGPDEKYIIKKDLTENLEPTWRAMEKLFKAGKAKSIGVSNWTIPGLEALLKYAEIQPAVNQVEIHPYFPNTELVEYLFVQDIIPVAYSPLGSQEGTGDRLLADKALQTLAAKKGCSLAQLLIAWGLKRGYAVLPKSQKADRIKSNFELVDLTSEEFAEISRAESRRGYRFVSCKELTEFNYDVWPEEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T915</accession>
    <name>A0A3D8T915_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Beta-coat protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BP5796_00261</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
            <orientation evidence="1 10">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasmic vesicle</location>
            <location evidence="10">COPI-coated vesicle membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T915"/>
    <dbReference type="OrthoDB" id="10261439at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000260">
        <property type="entry name" value="Coatomer subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011710">
        <property type="entry name" value="Coatomer_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016460">
        <property type="entry name" value="COPB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029446">
        <property type="entry name" value="COPB1_appendage_platform_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635:SF0">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07718">
        <property type="entry name" value="Coatamer_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14806">
        <property type="entry name" value="Coatomer_b_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005727">
        <property type="entry name" value="Coatomer_beta_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="12">
        <location>
            <begin position="24"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit C-terminal" evidence="13">
        <location>
            <begin position="681"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit appendage platform" evidence="14">
        <location>
            <begin position="822"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="496"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="496"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF07718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDW94498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="959" mass="106303" checksum="9312224A13687330" modified="2019-01-16" version="1">MASFLENSYSLVHQDNTADVPTMSDLRTQLEKGTDESKVETMKRILTVMLNGDPMPQLLMHIIRFVMPSKHKALKKLLYFYYEICPKLDSSGKLKQEMILVCNGIRNDLQHPNEYIRGNTLRFLCKLREAELIEPLLTPARACLEHRHAYVRKNAVFAVASIFQHSEHLIPDAPELIATFLETESDHTCKRNAFAALVSISHDKALAYLSGVFDGIPNADELLQLVELEFIRKDAVQNSQNKARYLRLIFDLLEAGATTVVYEAASSLTALTNNPVAVKAAASKFIELSIKEADNNVKLIVLDRVDSLRKKNEGVLDDLTMEILRVLSSPDIDVRRKALGIALEMVSSKNVEEVVLLLKKELSKTVDQEYEKNNEYRQLLIHSIHQCAIKFSEVAASVVGLLMDFIADFNNTSAVDVISFVKEVVEKFPNLRPSIVERLVSTLSEVRAGKVYRGALWIVGEYSLEANDIRDAWKRIRASLGEIPILASEQRLLDEVADGHEPSKDPEQINGHSKAAPTGSRRVLADGTYATESALTSQSAVAAKLEAVKAAQKPPLRQLILDGDYYLASVLSSTLTKLVMRHSEISPDTARTNALRAEAMLIMISIIRVGQSQFVKAPIDEDSVDRIMSCVRSLAEFAQNKELEAVFLDDTRKAFRAMVQVEEQKRAAKDAVEKAKTAVQVDDVVSIRQLAKKNAGDGTDEIELDLEKATGGDSAIEDLSSKLSRVVQLTGFSDPVYAEAYVKVHQFDIVLDVLLVNQTTETLQNLSVEFATLGDLKVVERPTTQNLGPHDFQNVQSTIKVSSTDTGVIFGNVVYDGASSTENNVVILNDVHVDIMDYIQPAVCTETQFRTMWTEFEWENKVNINSKAKSLRDFLTQLMACTNMSCLTPEASLKGDCQFLSANLYARSVFGEDALANLSIEKEGEDGPVTGFVRIRSRSQGLALSLGSLKGLNKVGEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9D0</accession>
    <name>A0A3D8T9D0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA damage-responsive protein 48</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_00909</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9D0"/>
    <dbReference type="OrthoDB" id="3050608at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40462">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40462:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW95146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="12809" checksum="60E71F7DE01429B6" modified="2019-01-16" version="1">MDYLKKAGESFSGEGSSNSNNNDQNQQHQSGGQQQESSGGGGFLSGIGNKLNSAAGGGRESEKNEDYLDKGVDMFQEKVLGQGPQDNESAFEQAKDEQISDFVRGQYKGVAGKDIPIQDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9H9</accession>
    <name>A0A3D8T9H9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Copper homeostasis protein cutC homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_00973</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CutC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9H9"/>
    <dbReference type="OrthoDB" id="7392499at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.380">
        <property type="entry name" value="Copper homeostasis (CutC) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00795">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005627">
        <property type="entry name" value="CutC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036822">
        <property type="entry name" value="CutC-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598">
        <property type="entry name" value="COPPER HOMEOSTASIS PROTEIN CUTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12598:SF0">
        <property type="entry name" value="COPPER HOMEOSTASIS PROTEIN CUTC HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03932">
        <property type="entry name" value="CutC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110395">
        <property type="entry name" value="CutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017709965" description="Copper homeostasis protein cutC homolog" evidence="3">
        <location>
            <begin position="23"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW95210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="225" mass="23474" checksum="B27BD4F4A7B04B87" modified="2019-01-16" version="1">MPFLEIACFTPASVLLAAGAGADRIEFCADASVGGITPSLADFQQLRRQTNIPIYVMIRPRGGSFVYAGSELAQMARDLVAFREAGADGFVLGILGRDGGVDVAECTPLVQLAGEKSCTFHRAFDAIVEEKMPAAVKDVAACGFKSILTSGGKPTAAAGSDVLRRLVVEARDQGMQVIVGGGVRSNVLADLQNQTDAVWYHSSAVTDGGLVADENEVKALKAILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9Z7</accession>
    <name>A0A3D8T9Z7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_01004</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9Z7"/>
    <dbReference type="OrthoDB" id="3244603at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003954">
        <property type="term" value="F:NADH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF17">
        <property type="entry name" value="NADH DEHYDROGENASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="6">
        <location>
            <begin position="6"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW95241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="413" mass="45748" checksum="1BE3614E602E1252" modified="2019-01-16" version="1">MSKKLVVIIGSGWAGATLSTSLDESKYSITVVSPEVTTPYTPLLASAACGLYDFNLVESPIRHTKKHIKFVNAAVQQIDFKSKKCYCKPAFEDIAVTEFALDYDIIVLSPGSTNNTFGTPGVVENAQFVRNAQHARKVAGIVQDCFEKASIPGLSEQQQRDLLHFVIVGGGPTGVELSSEMSDLFDGDYAKLYPHLKGKPSIAIHDVAPNVLSSFDTKLRDYAITRFKKHRVEIVTGSHIQSIEADCINTKETGRIPCGLVIWATGNKSTALVDSLPVKKTSKQQRILTDNFLHAFSADSEMMPDVFALGDAADIENASLPTTAEVACQKANYLAKCLNRGFDEPFHYRQTALVAYLGQNDGVIMGKRNYSGAQAWLAWRSKNFLWIRTWRQRILLVIEWFLVFFFGRPNAPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8TBE7</accession>
    <name>A0A3D8TBE7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_00881</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8TBE7"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF30">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="2">
        <location>
            <begin position="87"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW95118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="524" mass="58870" checksum="CC0098CC3D5F3B00" modified="2019-01-16" version="1">MSSSRKGQSIASKACDYCRERKIKGRRLERYRNATASAVAAIYDGVTPDASNNKSPLHVQNVVQAGVDLRIELLCPAETFQTIVYDFLDCMYPIAPVLHQPSFRKRLAAKEYEIDPIFFRLCISVCAFTVASLPRRISLYGFGFYHKFADMVNRACHMVMASRLATSPDWAERPTSDDMICSLLLGTASHYAQYPRRGWVLLNESIHCCRTLDLYIPKGYEGLSIVDREVNKRAFWMLFIVQIHDRLSHRNPHTTLAQDPVLTDWEFLMPLEVEDEHLQPGSMIAPTIPQNAPTPVISGFVILIKVFSCLLDLVAAPRKVAYSRLATQSTFPNLDTVSSPQSGSAASQNLGETMLSEDTLLRTMQSLENVLSDIPEDLKLFSPMNTSSTRAQQFEIMKANIHITKLYLQSWILDRCPIPPSGRPGSRSGLSPPENEQWNISREEIARQLLQVINICSQSTLESHGTSMVVKIREIAATLLDREPPSQAVLDITQPSQHYIARFLDILAALDIPAHQAITETRYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q3V0</accession>
    <name>A0A3D8Q3V0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_13212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000028">
        <property type="protein sequence ID" value="RDW56390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q3V0"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF1">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW56390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="32002" checksum="2D9BEB26AB0594D8" modified="2019-01-16" version="1">MSANIAQHDSSSTRQFTFDLTQATIATDSNPFLGATDATASGSSTSLLRAIITDYDKAHGIIMGVTVVLLLPLAALLMRGGMLWLHATLQMFNLVLLVCGLGIGVKLAQMEGYIVSRQISRNTVANPSVGSSATATSAFGARPTFFTGTGIPTFTSSPFGPPTGFPNRPFVKRAVLPGQVLQGVGFTHIVFGIALVALFLVQPILGFIHHHRFAKTQQRGFFGIAHQWYGRMLMGLAIINGGLGLKLAGNSMSGSTAYGILAGIVTLFYLIVLLFLGRGRKTMQKDSIATTNPTRTRTALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q446</accession>
    <name>A0A3D8Q446_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Luciferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_13100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000025">
        <property type="protein sequence ID" value="RDW56635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q446"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF30">
        <property type="entry name" value="XENOBIOTIC COMPOUND MONOOXYGENASE, DSZA FAMILY (AFU_ORTHOLOGUE AFUA_6G01920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="2">
        <location>
            <begin position="37"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW56635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="491" mass="54136" checksum="08AFE1636CB3039D" modified="2019-01-16" version="1">MATNSAGRKKVHLNFFETACTGNHECAGQWSRPGDNSCTKDTLDYYVNMAKLAEKGNITSIFFADTYAGHEVYGGNMDAVLRAGVQVAQLDPITIISAMAAATKSVSFGVTGSTSYIPPFALARTFSTLDHLSKGRVAWNIVTSWSEAAANAFGKELVPHDQRYEIADEYMDIIYQLWNASWADDAVRWDRENHIAYEPSRIKKIEHKGKYLKMSARHQMHPSPQRTPVLFQAGTSKSGQAFGAKHAEAVYIGGLVPSQASYQIKAMREIAKANGRDPTTIKFFAAINPIIGRTIEEAESKFEEAKQHADVIGALAQFSGYTSIDLSKYPLDEELKLDASKPKESAALGFLGNFTDSVKDGEVWTPRKLGEKIAIGGFHPSPVGTPAMVADIMEQWIDEADVDGFNMAYISNPGSFEDIVELLIPELRRRGLVFEDYAVPGGTFRENLLRQPGQKRLRNDHYGSNFKFESDFPYTNGVANEQSKEETAAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q4L0</accession>
    <name>A0A3D8Q4L0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_13075</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000025">
        <property type="protein sequence ID" value="RDW56610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q4L0"/>
    <dbReference type="OrthoDB" id="2848340at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000028">
        <property type="entry name" value="Alpha-L-fucosidase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049053">
        <property type="entry name" value="AFCA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016518">
        <property type="entry name" value="Alpha-L-fucosidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054363">
        <property type="entry name" value="GH95_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027414">
        <property type="entry name" value="GH95_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31084">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31084:SF18">
        <property type="entry name" value="GLYCOSYL HYDROLASE FAMILY 95 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14498">
        <property type="entry name" value="Glyco_hyd_65N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21307">
        <property type="entry name" value="Glyco_hydro_95_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22124">
        <property type="entry name" value="Glyco_hydro_95_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007663">
        <property type="entry name" value="UCP007663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 95 N-terminal" evidence="1">
        <location>
            <begin position="11"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 95 catalytic" evidence="3">
        <location>
            <begin position="282"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha fucosidase A-like C-terminal" evidence="2">
        <location>
            <begin position="701"/>
            <end position="743"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW56610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="783" mass="87434" checksum="5B2ADEA5C85F8B45" modified="2019-01-16" version="1">MREETGQELKLRYGAPAASWDEALPVGNGRLGAMMFGGTMTEHLKLNEDSVWYGGEPTPRRTPKDALKNLARLRHLIRSELHQEAEELVRNAFFATPYSQRHYEPLGDVILDFGHTFGNVEHYERTLDLERATTAVSYIHHGVKYSRQLFASFPDQVLVMQLDSQSTRTKFTIRVTRLSDKEYATDEFLDSVQAEETSGEGRGNWEGRIIMHATPGGRASNNFCLVLAVRCNDEGGTVTAIGNCLVVDSSRVTIIISAQSKYRHHDVETSALKDVEAALAQEAILTRHVNDYQSLFKRMQLRLSSQDCALHTNQRLQDVREGSLDPGLVALYHNYGRYLLISCSRNGPKSTRPLPANLQGIWNPSFQPAWGCKFTININIQMNYWPANICNLSDCEEPLFNLMQPMADNGKKTASEMYGCGGWVAHSNTDIWADTDPQDRWMPGTLWPFGGVWLCIHIWERYLFTRDKDFLRRMFNIYRGSVEFLNNFLIPNATGTYLVTSPSLSPENSFLIPGSDRKVGTLCEGSAMDMQLTNALFTGFAHILSELDIADDLLSSVQEKQRKLPPASIGVFGQLQEWQQDYEEAEPGHRHTSHLWALYPGRDITPETTADLAKASEVVLSRRAMHGGGHTGWSRAWLINLYARLGDPEGCLKHVTELLSKSTLPNLLDTHPPFQIDGNFGGCAGVIEMLIQSHEMGPNGTIIRLLPACPSAWDSGSLSGVCARGGLELDFAWENGRILGPVVLRTRTSTSATGVIVFPSGHNVRFLCQGHTEVVETSDQHHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q516</accession>
    <name>A0A3D8Q516_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_13002</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000024">
        <property type="protein sequence ID" value="RDW56935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q516"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000156">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF309">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="7"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="300"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW56935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="420" mass="45915" checksum="24C78CF612BFBF1D" modified="2019-01-16" version="1">MTEVKKAIIIGGGPTGLAMAMLLQLTNRITAVVYEIRHEPSTLGGALGIPPNGLRLLSRLGIYEKLLARGSSATNLVLHSVKGHDLGEMDMVSWSNEKIGFGYLRIKRTDLMAVLLEVADKRGIVVNYGKRISRITEQDQHVTAIFADGTEDTGDMLLGCDGIHSAVRSLFVDPDITPEYTGISNIFSLLPKSALSVPPASLNGLNATITTDGLFAVTSCTPTGDEAYWFSSREVPAPASGDSRDGWEEHRQKELDGFKGSIRTVLDEVKGSWGDTLRDVVDQTAVVKVYPVFRLPLGGAWSKERCLLLGDAAHAMPPHASQGVSMGLEDVYLLARVLDDPSRTLAQAFHKYEEKRRPRIKEIYDAAEQYGHLRRKTSGWRLQVNELAVAAGLGIYNTCKLQKLGLGQKPLVYDIESEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q677</accession>
    <name>A0A3D8Q677_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12759</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q677"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW57309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="134" mass="15349" checksum="A5FF9164EAAF42A9" modified="2019-01-16" version="1">MPYNAISTEVDSRQLLNGARVFGPSPSITKPSDYELNLDSQDIIDELESINMFRNKTKPLQKAHQEFFKKSIPTIFQHVRNIAFETRLSGWRAGVAFCLMTDFGTLVINFVLLVWAVGKHSVTHGYAQRHPWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q697</accession>
    <name>A0A3D8Q697_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12781</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q697"/>
    <dbReference type="OrthoDB" id="10472509at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW57331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="299" mass="33577" checksum="33F804F3EB526A8D" modified="2019-01-16" version="1">MPFICSERQNQINVAILLATVIHTLLLERRISSLEADDDLSYSSHASTSCSEHTVSKTPIAPTPGPVQSTKVVEVKGNGKGKGNGKGLSYRLIAKSDKTTVLQIAHSLKEHYGIVPDTKFWNRVAYQFSEQTSFPVHKALGRSVKAWIKQRKEFLGGLKPGEKDQKFSYHDAIDAWIRVEDARTGLKKARANGAGGVDEKTQRILQWRQDQFSAFANKTQMEVDTRNADFSREDEVEVPQASFETPSRNPLKRSRISTSTTPGPERKRQKKDKDPLIERVKKVTSYIVQLNADINNDKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q6B0</accession>
    <name>A0A3D8Q6B0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_13011</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000024">
        <property type="protein sequence ID" value="RDW56944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="195446at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="176"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="655"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="688"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="890"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="923"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="977"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1020"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1332"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1365"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1398"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1431"/>
            <end position="1463"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1486"/>
            <end position="1515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW56944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1603" mass="178252" checksum="679FE168B4D61036" modified="2019-01-16" version="1">MAEILGIASGVAGLISLAMEITRLSYGYISDIRSAHSTQKEYLREMSALTEVLLRIEEAIEGLEDQAVAMTPSTNLSKGAIRDCTKELDSLRSELEKPSPSIFWPLKELALKKTIQSLHQYRSIFSSFLAAQTLVTVSATHREVNRLGYHQDQTELLAWIGNPKDTSGPVLSPFPGTGEWFVESDTYRNWVVGNGSSLLWCHGPPGVGKSILASVALQHLSESLDGASVCLLHYFCEFSNRKEQKKEAIWKSLLRQVITQGRIQAIATLKSRLGSSRPASSKDLSDALDTICSSEKVIIILDGPDELENVKDMKAILNPFMKHHCKILVTSRDLPEIRSILTMASILEVQADRNDLRSYVASQFEENDLEDLLEKYPELEMEIIDKSNGIFLLGKILVNHLLELTTAKEMRKALQFYPAHLDQAFESSLERINSQSKSHSALAHRVIGWIVSAEKKLLMSELIHGLGIEEGIDIIEAENLLAPKTILKVCGGLVNANLQDGTVNMVHTTVYTWFRNRDTVHFHEDLARSCLRYLTIRPLSAGPAETAEEMDERMGNLPFLSYAAQHWRKHILDDTMERNLGDIINILLDNANFRSAAFQASNYQNRLKDLAIRSASFEAIPTHHSILHVAAYWNLPNKISEVLTDGGDLNTVDSQDWTPLHWACFGRSQKAIPVLVAHGAEIDAKDSVGWTPLFWAALNGDTATVQLLLTKNANHLERDMHSWTALRWAAARQQTDVIRILLNHHTKNLSRFQESRKTSLKQLSVQEALRYSTKKDVHSDLLDELQDQKITASLENYDSDDLYSILHDESFDVSQLWNSGHFDPPVGNVWRTMNKAERINGIEYYIEKKSIGSESPRAWRSNLLYAAIKDDRLLAVKLLIELGADVNDKKTRTPLHAAAFRKDPSMAEVLLDHGANIEAIDYQGLTPLQQAVLNGFEKTVKLLLSRGANVNFMCLDTEKEGTKVHSYKIHFRSETASSKTPLMLACGLSVPSEDPALPNRIVQLLLENGADVNMREIGPEGMTAIHYAARSRNPQILQLVIDAGANCTALDNLSRTSIHHLVLGIKETRMASPLLDSDGNCLPGMATSCLTILSQICGTEYLSQTAEWMEHYKVSRSCWEFMMSIHSPMSLAILLGDWEVFQGLRRFKARFETNVPLDTMLDEPFLALQPDAVDLLSENGANIPSKGAPWIGQIYALSSSHDITKKEVERLTAILIKLVSRGLDINTKGWNEQTLLHKTVFRLELCELTKSLLKLGSDPCQKDGDGLDSFILAGLSHNFDTLRDLLEHTKKHPIENHWTQYLDYSKTTQDSEIITAICSAIKIKGLIDSACKSGTLLCQAVRSGNEDFVRALVKYDADTNLGDDQGQRPLHFGAANGHTSIVETLVSSGAALEVCDKTERTPLHLSALNGHVEVIKLLLSNGASPITADSRGWQPLHFAVWGNNTEAVHCLIKAGVSLHATTSHYSSQGQRGKPSRLSYNNKWTGTPLHLAAMVGNVAIVKLLLMQRGGVNVNARTDNFELIDNYDSAPPVPTGGPTALHITLDNTKRFHELDRSFLEIAALLVENGASVEGVADHLNFEDIQKFQEFPQLWDALRVGISAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q774</accession>
    <name>A0A3D8Q774_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_12452</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q774"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF186">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="279"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="364"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="421"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="56"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="491"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW57651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="562" mass="62037" checksum="D0A1B1E426D35DB1" modified="2019-01-16" version="1">MERIERFLSRPSAKPYRSKTLEASEPPFLNEHGQVDFSPNDVENPKNWSAPRRWYITVVSVLLVVNATFASSSPSGSLTGIAEQFHVSLEAAGLVITLFLLGYCFGPLFWAPLSEFYGRRWIFYISFSLYVIFNFLCAFAPNFGSLLVGRFLTGTCASSPLSNAPGVLADIWPAIERGNAMALFACMTFAGPALGPVVSGFLELKEDWRWNFYVLLWMGGFTEIVMFTIPETLPSQVLTNKARRIRRLKIPGYENVKAPVEDSARSLGGIFKIALTRPWVILFDPISLLVAIYLSVVYALLYMLFTIYPVVFQQKRGWNSGVGELPLIGTIFGAIIGGTIVCVNSANDRKKEERGYQRRPEDRLPLAMMGGVLFPITMFWFAWTGEFNSVHWIVPTIAGAFLATSIVLIFVSYLNYLTDTYLVYVASALAANTVARSAAGAAAPLFTQYMFDALGVGGGGSLIAGVACLLAPIPFIFYKYGEPIRKRSKFAPTENNTVEPQQDVPRDHREVEIESDGSVHSNVASGLGIEKPVGLNDGTERDEEMNKASSSQNPEMDLEKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q7L0</accession>
    <name>A0A3D8Q7L0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Acetyl-CoA synthetase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_12478</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q7L0"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018376">
        <property type="entry name" value="Enoyl-CoA_hyd/isom_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF15">
        <property type="entry name" value="FATTY ACID TRANSPORT PROTEIN 3, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00166">
        <property type="entry name" value="ENOYL_COA_HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="297"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="700"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW57677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="799" mass="87018" checksum="ECB4ACEB9936CE0E" modified="2019-01-16" version="1">MAEPVVLVEHISSSIVKITLNRPKAMNALNAELLHTLVTTLREHQDAPVILLEGAGDRSFCAGEDLKQTLAPKTGSAEELRHSFDLLQDLTRLTSSSKALVVAAVQGYAIGGGAEIALAADFVIGGPKAVFRFPEVPIGHAVTGGISLRLVQMVGLLRAKELFLCGRFVDAEESLKIGLLSEMVENPKERALELAQQLAKLPRISASSSKSSLERAVFPNLESVLADEVNVANYCFAQSDAEKAFTDFAARKSKTNGSPDEVPNDQNLKTNKLLQATPGMTAVPATQELPGDLNTALERAVQQFPNAPFIRFSGSDTSFKEFDQGVAKLAGGLRSIGICRDDKVMVMMRNSLEMVQTWFASNRLGAVWVPINSELKGLTLKNVIEAGEPKIAIVDAEFYSEIKSCGNFNEKDIFVKGGTPELPSIDQIYNSGSPVHKHENVSPAAVSAYLYTSGSTGRSKPCVLSHQYFIIQASCAVTAFKIVPEDVLYCPFPLFHADATALTAVPALLTGCTAALSVRFSVSKFWDEIRDTGSTIYDFMGATLALLFKCPPTSNDRNHKVRLAWGVPVPTWAPEYESRFGHPIVELYGSVEAGLPVMQTGKRIVGSCGTVLPGYTVQISDEHDMPVPCNVTGSILVRSTRPNAFFKEYFNAPTQTLAATRNLWLNTGDQGHMDEQGNLYFHGRVKDVIRRRGENVNAFEVEEELLRHLQVITAAAFAIPADLGEGTEDDIKAVVVVREESVKEHRLTEIQLWEWAKVNMAKFQVPAVIQFVPTLKKTPTGKLDKLDLIADGGVKFSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q829</accession>
    <name>A0A3D8Q829_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q829"/>
    <dbReference type="OrthoDB" id="10332754at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW57820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="74" mass="7876" checksum="A5CFCCADAA89BBB4" modified="2019-01-16" version="1">MAGTDTSKNGGRDKTSAMMQDYLYSEASISERIAMGGGAGASQATRNNVTKASKKKASRAVKDFDANWERAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QAA3</accession>
    <name>A0A3D8QAA3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Galactose metabolism regulatory protein GAL80</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_12324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QAA3"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055080">
        <property type="entry name" value="Gal80p-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051317">
        <property type="entry name" value="Gfo/Idh/MocA_oxidoreduct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708">
        <property type="entry name" value="CONSERVED EXPRESSED OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43708:SF1">
        <property type="entry name" value="GALACTOSE_LACTOSE METABOLISM REGULATORY PROTEIN GAL80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22685">
        <property type="entry name" value="Gal80p_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="1">
        <location>
            <begin position="4"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Gal80p-like C-terminal" evidence="2">
        <location>
            <begin position="139"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW58394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="377" mass="40409" checksum="993657F320701142" modified="2019-01-16" version="1">MPIKLGIIGLSSQANSWTVAAHIVPLRSHPTLSSEYTVTALATSTQTTAVAAAEKWGLPFEKAYSSATEIAADPDVDLVVVGVKVPLHKELVLPALKAGKDVFVEWPLANGAEEAQELVTAAKDGGCRTIVGLQARCSPAVLKAKEILDSGALGRIISTDILGVDSRMIFFPPAYDYTRDAKNGANITTIIAGHVLDAMCFLLGEFAFLTANAKVNFPEVTTPFHDGPVSVTAFDSLSIHGELDSGTIATFQIFSTTSGMNSLTWIITGEKGSLKFKANGVAIQMDPPKLFWYQQAASKFGAEIYTELDGGPREIWEPVEVADPMAYGQVGEVYHAFANGEKVKGCLVDFEGAALRHRMLDACFKSARDGTRETYCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QBN0</accession>
    <name>A0A3D8QBN0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_12189</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QBN0"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF272">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="369"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW59265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="436" mass="46756" checksum="C9B454F79DDE8CBB" modified="2019-01-16" version="1">MSDPFEPYANLFANPAGPGDARPTAIEVIQDNDLINKWIGKTLLITGATSGIGIETAKALFATGADIFITARDLKKGQAVIDTIAKSSAGKGKLEVIEMNMTSLESVKRAAKSFLALSSKLNILINNAGIMAVPELRKTVDGFEQHFGVNHLAHFTLTTLLLPTLIKSSTPSFNSRVISVTSAGHGFSTVHFDDINLTHNYNQWIAYGQSKTANIWLANYIDRIYGPRGVHANAVHPGGIVTPLYQHITEEQMQQFSANTTMMTNMKSPEQGAATTTWAAVADVWEGNGGKYLADCAVGKPAVNAQALEDEGAAPHAYDVEEETRLWELSLKLTSVKTDSQALGDKYSAFKSDFAGFVGSFSAWAKPKVESENAKLKKLEEELKGMQQTLNNWATALHWSAGTMVVGGIVAVGVLALRPVGWPLLILGGLGALALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QEH1</accession>
    <name>A0A3D8QEH1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ketopantoate reductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_11644</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QEH1"/>
    <dbReference type="OrthoDB" id="73846at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008677">
        <property type="term" value="F:2-dehydropantoate 2-reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050838">
        <property type="entry name" value="Ketopantoate_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013752">
        <property type="entry name" value="KPA_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765:SF2">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43765">
        <property type="entry name" value="2-DEHYDROPANTOATE 2-REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08546">
        <property type="entry name" value="ApbA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketopantoate reductase C-terminal" evidence="3">
        <location>
            <begin position="355"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW60038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="502" mass="56822" checksum="2EADCA1C61372BF0" modified="2019-01-16" version="1">MPWTKSRLRVSPLLRNISVSKSNESLVNEEMTTDEPIYIFSTGTYAQFIVTALASGQNPPPLTLLTYSNNRIHEFRQAAGAVRILQDGLCHTAKDCEIELVPHSSKGYPNSATKTQQFEQLTNGSPSMKKSSKFSSATTTVVEPRIQEFFKEEMYWPTPYLSLTSWKQRPRQTRRRNQLESKRVDVQCGDKKASKQRAIQATDIPPAHKELKRNLIIIDEDPDSLIGFLSHLKKDLDCRSTILVFNQSVSIREKLIEIWPNVRNRPNLVSGVLGHRAYKQRGGASSVEGSSNDTCGNFTSTVVSGGKMYIGPLVRLEEGETSAVSARRRRDAGYLLGHVLGARLLNPAPVNHSTIDELRLHGLLVGSVLGPLCTLFEKPTCDLFEGEGRQERAELAYDLLQEARRVLVRFDRSLTVDKCARWLRQKTDVAYKAVPLMTRKFFQLRSSGTKYRNEWIIAKGESYGLDCPTHKFVVKLMKEKLVLLAAEKDCPKNKRRTLEWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QEH7</accession>
    <name>A0A3D8QEH7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_11743</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QEH7"/>
    <dbReference type="OrthoDB" id="10256176at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01725">
        <property type="entry name" value="LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000009">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016654">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829">
        <property type="entry name" value="SNRNP CORE PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829:SF2">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="9">
        <location>
            <begin position="150"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW60137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="249" mass="27564" checksum="084141E198B5D260" modified="2019-01-16" version="1">MGVLLGQYLKGLAMRVREATDIASITCRGAQLHLRGKLSLSDASEVRPPTLDRRRNFLLPSPATCLHIDCMFEVTGCMRLEISELFASRVVEVTDLANHESAVHGSSRPRSSLRVASGSINSLRFDYSLSSQTLTPAPSRPPSSPKIKMLFFSFFKTLVDHEVTVELKNDIQIRGTLKSVDQYLNIKLDDISVVEELKYPHLNLQSSVKNVFIRGSVVRYVHLPGGAVDTALLEDATRREAAQQATKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QET4</accession>
    <name>A0A3D8QET4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_11776</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO1/REXO3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QET4"/>
    <dbReference type="OrthoDB" id="206335at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06145">
        <property type="entry name" value="REX1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000019">
        <property type="entry name" value="RNA exonuclease NEF-sp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034922">
        <property type="entry name" value="REX1-like_exo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF115">
        <property type="entry name" value="FI18136P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="8">
        <location>
            <begin position="431"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="66"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="131"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="247"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="710"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="327"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="714"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW60170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="853" mass="93855" checksum="2F00BFF1EB7819E5" modified="2019-01-16" version="1">MHVKLMKASYQENVGVRHELGHDLLLTFGRVNKADLAAASVAQNPQALTISRFLCARKPRWSSNRSYYGARKSQSVSGPNTMTETKDTAQSDSNGSSGKKRKLEEVESTNGMGLPLSLLRQPELPEFNLTSSRHASQDAGLSKTTDTQSAEEWTTVEHSRPKKKAKKIPKKESSNYPSIRFSSNARLQSQIKISDLQSLLLYVLADGTSPQWVSVSNRNEIRKLVVLMIPGLEESMFDKKLAVGHSKVDDSNAHSEEDQKDAPANRSDGQSPDDYYPRRLKTEELLKPLQPFAEMFEHIWPVKTPGDDRFGKMHSPLHAMLTAPGQKSKEDNYRGKNGKGPDKAREPQGWKNNRTRITEFIHTADELLENDYVLHPASYKEEAEKEMLQVHRRTAGTSEEDGWVDTAAKDFENGTVPENEIESGSLTAGRELLAMDCEMCMTGENEFSLTRISIVRWDGEVVLDELVKPDKPIINYVTQYSGITEAMLAPVTTSLKDIQQKLVEILHPRSVLIGHSLNSDMTALKMTHPFIIDTAIIYPHPRGPPLKSSLKWLAQKYLGKEIQKGHGSTGPGAGHDSIEDARTCLDLVKQKCEKGKEWGTSDSQGENLFKRIARTGTRYKSSNAGATASGISGGKTSAAIDWGDPRKGAGNGATHTIGCKNDEEVTEGVIRAVKGDPDGKEIPGGGVDFVWARLRELEALKGWWNNNKNAGTEAAERDQKAREEAKSKAAGPGSEGDAITTEAEMPGTATETASTSADQEKPQTEVEIATVALTARLAKIHAALPPCTAIIIYSGSGDPREMSRLQAMQAQFKKEFKVKKWDQLSVKWTDTEEQALKKAAKKARNGVGFVGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QI62</accession>
    <name>A0A3D8QI62_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sorbose-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_11428</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QI62"/>
    <dbReference type="OrthoDB" id="5325318at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009688">
        <property type="term" value="P:abscisic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF115">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW61536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="254" mass="27166" checksum="47876805BFA0B86D" modified="2019-01-16" version="1">MSSRFDLKGRTALVTGGARGCGLAFAEGLAEAGADVAVFDVIEPVEGFHAISSMYNVKTKSYIVDVSSIESLEAGFAAFKADFGGKLDICVPCAGINRNVGFLDTQFEDFEKLLGVNVKGVYYTAQLAAKQMIENQTKKGSIILVASIASYMAIRSQMSSAYCGTKGAVRAMCPAIAAELVKYGIRVNSISPGYVRTEMTSPFPHLLESWKDEIMNGRVAEPEDIRGGCVFLASDASLYMTGQDLCLDGGVTKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QIG8</accession>
    <name>A0A3D8QIG8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_11352</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell envelope</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QIG8"/>
    <dbReference type="OrthoDB" id="4987761at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051648">
        <property type="entry name" value="CWI-Assembly_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018:SF3">
        <property type="entry name" value="RECEPTOR PROTEIN-TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31018">
        <property type="entry name" value="SPORULATION-SPECIFIC PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="460"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="490"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="523"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW61460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="552" mass="60184" checksum="3D9EF8EF1B8C96C1" modified="2019-01-16" version="1">MGQNLSSTKINDTALDVVAAPDALNDLHLGIFFGGSFYAIGMIWFTIALIDRWRGPNGDRKTGFASVIAAFILITLIPDQSGYCSESGTPYASDYGPFPDWDISDQSDADALTLTGCTAFGVNIRVHNDTIDSIELNGVRSVRSLNVSSSAALASFQAPNLTMINGSFTLYDLPNLTIVDLPAFEYAVIVDWSNLPVVWEVASWTSNAITNALSIRNTSLLNIAFSGGSSNSSEAQPVDQYYSELIITENRHLEYINLPNITHIESCNISGNDGYLQTIDLSGLTYTGAMFLSKAPLELRFPKLESVTGTFDLSNSPDLFELDLNALENVYGTFSLVGNKGLTTLNVSSLQTTDSLVMENNRIAAFEFPSLTSSTEISIEGQFNSIDFSKHYSSFDGPVNITSVSETLNCTALDIIHYHTIDFEGTNFNYTCRASPMGDTRDFAVHFHYISAKSAKTKRIIIGCVVLTLAIFLGLLLWWRRSRKRTAAAAARENGTAESGMELPPRYRRTGLEGEIPPAYNVGGSTSSVQSAEIPNRVAPGEPTPNYEESRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLI4</accession>
    <name>A0A3D8QLI4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pali-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_10873</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLI4"/>
    <dbReference type="OrthoDB" id="2354757at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035838">
        <property type="term" value="C:growing cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051380">
        <property type="entry name" value="pH-response_reg_palI/RIM9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013:SF7">
        <property type="entry name" value="PALI-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28013">
        <property type="entry name" value="PROTEIN DCV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW62571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="26373" checksum="68B1ADA868E76654" modified="2019-01-16" version="1">MAKTGIFHHVGTFLLFAAAILLLITTISAPVITDIGILKVTLTNQSDLRNSSINFGTFGYCTLDVAPASSDQDYCSGKHIGYNPALIMAEADGTAFGSMSGDSTKALTRVMVLHPVGCGLAFIAFLFALGAGVFGALLASLVSALAFIITVVVMAVDFTIFGIIKNKVNKDGTGSRAYYSIGMWTTVAAMICLFLATFIVFFTCFSARMHKRRNTHSTKAVDAGYPGGYTTTKRHFWQRRARTNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QM97</accession>
    <name>A0A3D8QM97_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_11072</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QM97"/>
    <dbReference type="OrthoDB" id="2158884at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07830">
        <property type="entry name" value="STKc_MAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000233">
        <property type="entry name" value="Meiosis induction protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000314">
        <property type="entry name" value="Serine threonine-protein kinase mak"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="29"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="363"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="633"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="713"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="376"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="411"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="486"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="718"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW62770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="800" mass="88031" checksum="EF0E688C08366F2B" modified="2019-01-16" version="1">MTVAYDLTHRGLVSSTPPATSGQALEDRFEVLKDIGDGSFGSVVLARVRSAGSNVARRGTVIAIKTMKKQFESFAPCLELREVVFLRTLPNHQHLVPALDIFLDPYSKKLHICMEHMDGNLYQLMKARDHKCLDVASVKSILFQIMQGLEHIHAHHFFHRDIKPENILVSTSAQQDSGNSFRRYSAMVTPPSTPPAYTVKIADFGLARETHSKLPYTTYVSTRWYRAPEVLLRAGEYSAPVDIWAIGAMAVEIATLKPLFPGGNEVDQVWRVCEIMGSPGNWYNKQGAKVGGGEWREGTRLAGKLGFSFPKMAPHSMDTILQTPQWPASLSHFVTWCLMWDPKSRPTSTQAIAHEFFNDAVDPLRPKSSSRMLGRKHSDLSYRGSKDPTETTTPTGSKPSWFRKSLIGRTENATVSTSQQPAGKENLAPRPSPVHSSTVNDIPVAKTRPAAGKRSTWTNGQSNVAPMPILPTIKPISPLSDTVTAQANSRTPSYSDAYSNGVQRLPGHDDKVAKKIGRQLSVASNSNHYAEIHRQQAEMALNGNTGLASPPNGQKESFFSHLRKRARRFSGRNQTPLSPKSDDVEAQAGCGPWASNRSSMVIDGNMLPNPVQRVENHDALDKALRNVQQNLDSQTGTVPVPPSHMINPSSVLKRHHSLPQQQQPRSGDNLRTGAPISSRTRRSHNNGANHYDTPDEEDELLDEVLKSTHKANKRLERNSLQAEPTKPLRQSNSNMALSNPYPTPSPSANGNTVLFGQGLPGITPKHSEGPKQSSTPPYDFEENEWAASAAASIFAAQSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QMW9</accession>
    <name>A0A3D8QMW9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dual-specificity kinase</fullName>
            <ecNumber evidence="2">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_11106</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14210">
        <property type="entry name" value="PKc_DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000112">
        <property type="entry name" value="Putative dual specificity tyrosine-phosphorylation-regulated kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.30">
        <property type="entry name" value="DYRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042521">
        <property type="entry name" value="DYRK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF22">
        <property type="entry name" value="DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="1005"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="109"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="567"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1305"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="256"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="315"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="491"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="506"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="583"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="623"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="653"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="681"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="724"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="762"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="789"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1325"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1360"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1384"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="1034"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW62804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1435" mass="155358" checksum="1BC27EC4D414278A" modified="2019-01-16" version="1">MIRDQKAPLGPRQNNSDYDSDENHDPISRTHVAAAREPVLSASSRNNHSLFSFGGHTEPDEPYASSAPFDFLPSVSFDDLQSSLVSASNDFKLIDFPDSAVGAGNMAAVKTNGGRLDPAKPDGQTVPRTRIVSGPRPPPGPARNTSVARRQSLSTRQVSGSSTTSGTAGSMDPPSAPLAMRTRRQNQYPPISGTGPGKGTRKSIGPGGLTVDQSSGPPPRRRPSLISNTSAQGHTDGATLGRINISAGEHRHEGGATATTASRAAKTKSLQPPSRQGQTNLSVVTPEHSRSSSYAGKSPGKSGGRTGTPSSAKRMSMMPGMPPSASHASGLGARTISPTDARRAKRMSILHNAPPMPHTPPTPQPDASMTRNSSHSPSMLPRKAPTPSSSRATPDIANRKSYSSGLSIASTASYNTARTSTGSLQARVPAAPSTSRLPTPKPRNVHSSAGNDDEEEEVPPVPAIPKAYESPKDSPAEAPFKRKPSMAFDASSINSVSTNSLSGKASIREVAKSDVESNKSRKVAPTSSNVDFDHTNHTTPVNVKKKSLQPLRLPPLNLLPLSTPTTAKIAALQQPGASDGTVTPPARRTNTKTPTTPLTTSKSSFFSKGRSDDKATQHSRAMRSSSSTHHLRSGSSSVQDTSSSDSSKPVSTAQQQHSRNAASPYISSSLPKAADEHSFAPRSQTSGDFSTTDIAYDQRHSKLTGPRAQKLVKAAKSETPTQVSSPDEPTTPSSTSSSLRRKLSLGWKRSTSKSNINISHAATERESEYAPPPPRHDHMLPPRLPASATLNNLNNPTSVPSPSPSVKSINYLDSKRRKSSASSLNILSGHDRTRSDSWGLNRSPKKDSTSTASDKPPSTAKTASSVMHKMLTSKASTNAMRSHEAARSQDPWTADLDRDDMTAEEEMRKLGMKRKETEHAARQLDSLRKRATPKDRVTAAQAIQAANLNIYERGEIVDYKEVYFCGTQNAAKHIGELSSENANFGYDDDRGDYSIVPGDHLSYRYEIVDVLGKGSFGQVVRCIDHKTGGLVAIKIIRNKKRFHQQALVEVNILQKLREWDPKNRHSMVNFTQSFYFRGHLCISTELLDMNLYEFIKSNSFRGFSLKIVRRFTKQMLSSLLLLKHHKVIHCDLKPENILLAHPLHSEIKVIDFGSSCFENEKVYTYIQSRFYRSPEVILGMTYGMPIDMWSLGCILAELFTGVPIFPGENEQEQLACIMEVFGPPEKHLIEKSTRKKLFFDSLGKPRLTVSSKGRRRRPSSKTLMQVLKCDDEAFLDFLTKCLRWDPERRMKPDEAVRHEFITGQKSGMPIAARTSARNDSPIKRFNTTAPPSATNRPLPEPPATSFKNGTAVRTREATLASPSKPTSSYPPATTYAGPRRASTVGVSFTSNGGKRVSTGTTVPVGSSLPRVATRSTSGRQDLASVGATVAMSRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQ98</accession>
    <name>A0A3D8QQ98_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alcohol acetyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_10498</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW63996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQ98"/>
    <dbReference type="OrthoDB" id="2150604at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010828">
        <property type="entry name" value="Atf2/Sli1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07247">
        <property type="entry name" value="AATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW63996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="47591" checksum="F715BB3001F505D5" modified="2019-01-16" version="1">MANTSILKFALAKNILRHPNLCHGITDLDPESGEAHFTRLEAINWSSVVEEHACVRGQSPDEELASLMGKAHQTLFTDQERSPAWKILLLRHEDLKVVDLILVAHHAICDGMSATAFHQSLLGFLLEGAASAKPETNWIVHSEWPVKVPQTVTAPVPVERFIKLSKEQSSIPETSSPPSTFTPWAANPPTLSTFVSRAHFLTVPRHRLDSLIEFCTRLGVSLTGYIHSLLVSYLSVNIPSAQGFKSGTPYSLRRFTGCAAAEMVNHMSSIDSNWDEELVQEIRRSSKTVAEEEQIIQKISQQFRADLKRETARVLLDGPTMLRDISQIKNLGQFCEESMKKRSYTYELSNLGDIELPTPEQEPSKLRAEKLLFTQCGMVTGPAFGCNVVGVKGGDLVIGITWQEGIIEEDLIFGMARFLEGKITQVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQD1</accession>
    <name>A0A3D8QQD1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_10507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQD1"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF10">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="59"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW64005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="312" mass="34007" checksum="8D7D4DB814DE47C3" modified="2019-01-16" version="1">MASPTPAEAAPPNTDPTFRSYSASQAQTYATYRTSYPERFYRTILDFHHATGGQDGFLVDVGCGPGNATRDLARFFDVALGVDPGAGMIEAARGLGGVTKRGGPVAYEVAAAEEFARVTGEQPVDLVVAAMAAIKFLPYVYIPSGLGIKQCQRPRKLHKTIDLPLPDPQKPHASEINKILLRLERETLAPYAVPANLVSMNMYDTLHLPWANNPPVSSFPPESFQRLTYDREGVLSDGEHFFGGDEEVNIEELEKGLSTASMVTRWREANVEKVGTEDDVVRAFAKELRDVVGPRGVLVKGSGTAILLFKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQG4</accession>
    <name>A0A3D8QQG4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vps72/YL1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_10392</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW63890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQG4"/>
    <dbReference type="OrthoDB" id="49520at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029525">
        <property type="entry name" value="INO80C/Ies6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31200:SF1">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="6">
        <location>
            <begin position="141"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="55"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW63890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="192" mass="21116" checksum="673A9DDCCBE8F3E4" modified="2019-01-16" version="1">MPPPPQKDDDGAHLRLIGQLDIYSVPKPFRNPSWKPNQRRNKNIKTILGDASRKEASVMATNENSVAVTPFRDDSATSTDGEGTPARSTQSSTLQPNLAQASRNLSKLVLERNMRSNGFNSAPNVTYTNVECAPSLAHSKHYCDITGLAAPYTDPKTRLRYHNKEVFGVVRSLGQGVAEQYLEARGAHTILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQY3</accession>
    <name>A0A3D8QQY3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_10725</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQY3"/>
    <dbReference type="OrthoDB" id="2367685at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW64223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="32485" checksum="305D3C58529BC0AB" modified="2019-01-16" version="1">MASSSSTDAPPSYETAIAPPSQGNAIPKIRNGIPHQTRRSMEDESRPLPEGWVRSYDPDSHHQFFVDTRRDPPASIWEHPYDNEAYLSSLSPEERAHIKGIHRVPSERDVEAESSDDENHAADGRHPPLPPRSKEEPLGGVHKLGRRMKDKLTNSTHQEREVKREERAKEEQATYERHQKIRAAMSRAMETGEPQLLGKDKNGRDLYIEPPPGIGSGNRAYNGGVGYSPYNNGRYGYNSTYVRPQYPYHRPNRYGYGYGAGYGLPLGLGVGALGGGLLLGGMGGGFGGGMGGGFGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QR90</accession>
    <name>A0A3D8QR90_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_10690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QR90"/>
    <dbReference type="OrthoDB" id="3438854at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW64188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="152" mass="17649" checksum="366D5B7A08A457A3" modified="2019-01-16" version="1">MAPHNPHKEASAKTKKSSRRNKHKHAEIVVEAEDNQETVGSARNLWEAQVKVRNQQRKAISSELKHIVEDLGEKIDTLAEKRRDRVQKLHQAEWDRLRSLIQQRREVELEILRSMNALESRSERIVRDLEAILAGREQALNSLGIKMKRPQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QTS4</accession>
    <name>A0A3D8QTS4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_09877</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QTS4"/>
    <dbReference type="OrthoDB" id="5386330at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF15">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW65185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="479" mass="53648" checksum="4C89D67F5E80068C" modified="2019-01-16" version="1">METPIARRSHFGCTRCKRRRQKCDEKRPSCGRCDDAKTECTYTLTLRWGGRASRRSKVIAETASSTPKPIVKEPLREAESLAIVASKNTTPTQSSITAQIEPLYFLSSSTRFSLHYFIHRASHATSSHPRIQERICGMIVPMALETPSLLYATIALSELHRSSLLDDFPENFDQPAGIISRSLALSLQTLQSDLTQGRKSNRYATLTTIRTLCIFEIHSGKAAPDSWRAHMEGAKALLTATRNMYGTQAIDESDPQWLIERWFASIESFTALTERGLLKGQLETFGSQSRVRSPTTDDQYLDVYSAYTGALNAAFKEIGAAAWERRRLNTSDEESKLLTQHDLDLEATSLESSVRSMIGRSKFHPGVQTFLTAAEMEQFKASDEAYQYTALIHVQRRVHLLPKSSLEVQDTVKKIIQCVKKISPVPGLSPWVMATTPLFAAGREALGNDRNIDSQCKEVPGHIRTELENGLGFRRNGFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QTZ1</accession>
    <name>A0A3D8QTZ1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">1-acyl-sn-glycerol-3-phosphate acyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_09951</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1-acyl-sn-glycero-3-phosphate + an acyl-CoA = a 1,2-diacyl-sn-glycero-3-phosphate + CoA</text>
            <dbReference type="Rhea" id="RHEA:19709"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57970"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.3.1.51"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="4">The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.51" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QTZ1"/>
    <dbReference type="OrthoDB" id="202234at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004552">
        <property type="entry name" value="AGP_acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00530">
        <property type="entry name" value="AGP_acyltrn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF11">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="4" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="6">
        <location>
            <begin position="103"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW65259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="303" mass="33381" checksum="FB07ACF694C6537E" modified="2019-01-16" version="1">MSAFLHYSALFLEVYLGLTVALYMLSMRLSQAGFFARLLAAYASLVVCACYGVTVSIFFRLIGYPGLAQWATARSFKYVMQLTTGVTCEIEDPNDYLNTTRPAVFIGNHQSELDVLILGHIFPKYCSVTAKSSLKNMPFLGWFMRLSGSVFIDRANSKNARNAMEGAATHMKKDKQSVYMFPEGTRSYAKEPMLLPFKKGAFHLAVQAGVPIVPVVAANYSNLLYVPDRNFQSGVIHLKVLEPIPTKNLTAADVEDLTRDTRELMLREIISLTAKQQGKPIAMSAHQNGDGLVKASGAEATIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUJ0</accession>
    <name>A0A3D8QUJ0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_10114</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUJ0"/>
    <dbReference type="OrthoDB" id="3438628at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW65422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="297" mass="32923" checksum="95C574DB66E08384" modified="2019-01-16" version="1">MPRKDEDAHDWTPFELHTLLCLMARGYHLGGMQKRTKGSTKDELQAAATRHAYLDLATKLNETISRGNFINDIPVKTIFNKIDEILETHKGPIAYMERQRVGRMTRGLKYVFARSPPIGFTGTKTEWESGRKEKVMEEELAKRTAVSIAAMAAGNDTSNGVILPSLEGSNLQASASMGTDLNLNREARLGGSLMKSTSYTGTSKVLPTNGKARKSVGAVADISEDPVDQFFDQWERELLTQPSLAPATYMFSSRQAMINNANNEDFSDQEAGGIDYTKKPTARGENMVPLPFNRLER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QXW2</accession>
    <name>A0A3D8QXW2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_09368</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QXW2"/>
    <dbReference type="OrthoDB" id="2131701at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14200">
        <property type="entry name" value="RicinB_lectin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="3">
        <location>
            <begin position="128"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW66619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="245" mass="25763" checksum="51202B81A7BC4BF0" modified="2019-01-16" version="1">MSGLLRDTRNQPGLEVAPPVPPQDIEYQTKDAPPYVNYEPSKSSTRICGLASRTFWIVFALVLVVIGAVVGGGVGGGLSTTHKSASIPTQQHSTSSISASSATSISSSTTTSTTSSSTISTGIPPSSTQPGVYRIINISTNTAIDLFWGNTANGTEIECWQWNPDATPANYNHQAWQIALLGNGAITIMNLQAKSYITAPNNLTVGTNPLNSAADAAVFGGGTQGNPEDPHVQWFLIRNSDNSVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYL5</accession>
    <name>A0A3D8QYL5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS transporter-7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_09509</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYL5"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF83">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="473"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="55"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW66760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="528" mass="58634" checksum="DE7D2FD2405AAD16" modified="2019-01-16" version="1">MDIKEEAKTTDDPAPAASMKKGHLLEIDTTRDFTNAEHELPFWTAVQQYPQAVFWALFFSIAVIMAGFDAQLVTSFYALPAFQQRFGTLYEGSYIISAPWQTGLGMGNPIGQILGALACGWPLEKLGRRMTLAICCVWSICFVFVQFFSTSIGMLCAGEILGGLAYGFYVVIAPVYASEVCPLALRGVLTACTNLAFVIGQFIAQGCSAGLESRLDQWAYKAPFAIQWLWPAILLAGLPFAVESPYWLVRKNRKEDARKALERLSSSKHRPDIDAALVLIEQTDLLEQELEATTTYFDCFKGCNLKRTEISVMVYLIQVIGGNPMIGYANFFFEQAGLSASESFNMGVGNTALGFVGTCLSWPLMSYFGRRTIYNSGMTFMTVVLFIIGFLDLGRTHSGVVWGQASLMDIWTFVYQMTVGPICFVIISEISATRLRGRTVAIATAVQAFASIIFTVAMPYMLGSDQANWRGKAGFLFGAISLVCLIWCWFRIPESKGRTFEELDILFEKKVPSRDFGKYDLMHEHESA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYN9</accession>
    <name>A0A3D8QYN9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_09540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYN9"/>
    <dbReference type="OrthoDB" id="5089701at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF32">
        <property type="entry name" value="ARGININE METABOLISM REGULATION PROTEIN II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="36"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW66791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="722" mass="81386" checksum="8511AA3D5CBDDEED" modified="2019-01-16" version="1">MLGPGPAGKKPARPKALAPSPSQPTKKRERKKTFTGCWTCRSRKLKCDETHPACRQCSSKSLECAGYGARLHWLPCSDGRDRDEGKSKIRMEGGQRRMVVRGKLDTPFTEEEIDKALREIDELRNGPEHECAKGPFNVFNSNASFQDHEKKENPSKDDWGSLPGNDPLADINWEEVENLSSSGLFTEQADSMLMLGFESSDVLTNLNTDVLDYGAPSSSLRSSDEDSYEPFHFSSRSTSISIISDDERRAQENALVFTQPYRSLQNYSSEPRIMTSQNRLLIHHYVQNVVDIMASISTDSSPWKSVHLPRALQGSGEIEATGRTSNSRNALLHAILSTSAYNLASQFLHTKQEELARQYRILGQDLFCKTVCLIQNCMQEEIDGRGPKYKELLAAMLSVISIGVMSGNTRNTRVHLRGCESLIRIMKEKRLKPTSSKARVLHRVYYYLKVMQESTASTRDLIFQDTGSNSPRKLVSEAYYPRMKPQSTSLEAIAEWLNIRKSNEDDFESFGCEFLYGVPQDLIILIGKSTDLVQDITLFWASHPDAVLPPELIARCDIVESEILDWPIDAALSSPYIQTATPERQEIIYHQTQAFHKATIIFFSQHVRPIHRYHLQPYVLAVLDHVCAIETIKTSASVLGGALLWPGVIAATEAVDEFVQKRFLDWMDSVASKGIGSTREARKVLVELWERRRTVQDEKAGKMVRSGWRTITEARGISLMLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QZ60</accession>
    <name>A0A3D8QZ60_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peroxisomal membrane protein PEX16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_09603</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peroxin-16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QZ60"/>
    <dbReference type="OrthoDB" id="2021143at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013919">
        <property type="entry name" value="Pex16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13299:SF0">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PEX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08610">
        <property type="entry name" value="Pex16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="2" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU365003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW66854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="369" mass="42466" checksum="27FE60B17CF6669F" modified="2019-01-16" version="1">MTATTATPALRMESIKTTTRRVPNVLALYSEFIQKNQSSVTQIESALRSLTYVIPGRFRDAELASESLHSGVQLLSMYHDTLLMRAISKLPGMPRQQSPHNRYTKFWIARSKFYRRIATLLSMIQYTELLWEMTAKRRGERIRWRVVVILEVVKAMCKLCLLRITNSRPLVTPPLPERELVPEDASSEDHEENEFAEIVEKPKECKEYKMKRTGMSIPTLPNPSDISNYLLSKVLTADDIKAPSALLNKVNGSAQLAELLHIIQPVVYAIAMSRSKDKKNWQPWLLGLSIEYAARQLRKDGLRTTALEREEWNKRGWAMGWWMMRGAFYENVTKGFLTSASQRLPSLMSGILDDYLYLWDGYYFSTSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QZ68</accession>
    <name>A0A3D8QZ68_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_09816</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW67067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QZ68"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF62">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="55"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW67067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="484" mass="52734" checksum="2BB0D02E47CC7462" modified="2019-01-16" version="1">MSSAAAKEAYGVASHVEEQTLGSKADVVVIGDYAGAVAKDSPVEIALVRKLDLRIMPTLWAMYFLNYLDRNAIANSRLDGLEDDLGLVGNQYNTCISILFVGYLLMQIPSNMLMSSKSIRPSIYMGSCMAAWAIVSACTALVTDYKGLVVVRFLLGVTEAPFYPGALYILSIFYTRKEIALRISILYSGNIFATSFAGLIAAATFASIDGAQGLKGWQWLFIIEGVVTFFVALLAMYLLPDSPSTTRWLSPEERQLAAARIDRDTVGLEPSKGMKEGFKQAMGDPMVFVFAFMQNMHLSACSFNNFFPTVVGSLGFDRTITLVLTCPPYLVSGFVGYLVGYTSGKYNERTWHITISMGAAMVGFIISCVTMNTAARYVACFLFASGAYSVNSVILGWVSATTGQTQEKKAVSLSIVNVVANASYIYTAYLYPKSDGPKYLTGMGANSGFAFATIATAWIVRIWLKQKNKKIRASEAEAQVLFAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QZD2</accession>
    <name>A0A3D8QZD2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09797</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW67048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QZD2"/>
    <dbReference type="OrthoDB" id="411145at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052961">
        <property type="entry name" value="Oxido-Kinase-like_Enzymes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020:SF41">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23020">
        <property type="entry name" value="UNCHARACTERIZED NUCLEAR HORMONE RECEPTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="1">
        <location>
            <begin position="85"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW67048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="402" mass="45262" checksum="1AAA4482DD857244" modified="2019-01-16" version="1">MHSQEEVERVASKLLSTKDLKLVACRTLQSLWAGYGHICEIKAVPSAAGHASQQPSSFILKYISPPATNRKGTPKEGHLRKILSYQIEQYFYTHLAPQMPPSIGVASCLASIDDRSGSNATAMIMTDLSQEYPVAGEKRGELNETQVYAAVDWLATFHGFWWGKTQSFERSKLCRPPLEQFQQTKSTTADEGVWLNGGYTYLATRRDEYRDLSASDSEWCAPLCSRLTDFEGQPTVAELVASFLAPLADGGKEGPISKYETLIHGDVKSENLFTTARGDAVAFFDFQYVGLGLGVCDLAKLFTCSLPQELLSVDSFGSEDEIEMGEGEQILLRRYLDKLEQVSGREYEWDVFVRHWEIGLVDWLRFQASWGFWGNTEWLEGRVRSVINDPEWKAYLERETKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R2S7</accession>
    <name>A0A3D8R2S7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein-17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_08907</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R2S7"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000643">
        <property type="entry name" value="Short chain dehydrogenase/reductase family oxidoreductase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="267"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW68250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="299" mass="32764" checksum="A99C886065010641" modified="2019-01-16" version="1">MAMQVANKTAIITGAGSGINLCFARLLLNKGCNVLFADLSLRPEAEELVSRHSSAGGRAKAVFQKTDVTDWRQLERMFGTATKAFGGADIVCPGAGIYEPPWTNFWNPPGQGRSKDKIEDSRYALVDINITHPIRTTQLAISHFLAANKPGVVTHITSVAGQVPFFPTPVYVASKHAIQGFVRSLYRLEEPRGSLPKIRVNAVAPGLIKTPLWTEHPEKMKFIAEDDQGWVTPEDVAKVMMDLVEREEHVGGTILEVGKSVRKVETFMDPGPPSDKNAVHHSSAVEDDAWSDLGKQWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R2W2</accession>
    <name>A0A3D8R2W2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_08937</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R2W2"/>
    <dbReference type="OrthoDB" id="16816at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050602">
        <property type="entry name" value="Malonyl-ACP_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13090:SF1">
        <property type="entry name" value="ARGININE-HYDROXYLASE NDUFAF5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="329"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW68280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="352" mass="39308" checksum="CEA845AF33962F0C" modified="2019-01-16" version="1">MKPMILRPFIPRSAFRRKTWISRSYAVQSPGSPTLQVFNRRTKYLQKERAAADVERSRQADYLKDEVAIRLTERLLDINRHFPHVLDLGANACNIARALTLPNPDPDPSKTTSPPLSTRLTQLTAAESSRALLYRDADLPFNKELNLTREVLEDEETLPYPANTFDAVLSSLSMHWINDLPSLLSQINNVLKPDAPFMAAMFGGDTLYELRSSLQLADQERRGGVSPHISPLADVKDMGGLLQKAGFKMLTVDVDDIIVDYPDTFALMQDLQAMGENNATLGREMSGIRREVLLANEAIYKEFYGNKDGSIPATFRMIYMIGWKEGPNQSQPLPRGSGQINLTDVLGGGDVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R2Z8</accession>
    <name>A0A3D8R2Z8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_08977</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R2Z8"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="246"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="338"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="4">
        <location>
            <begin position="45"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW68320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="438" mass="47311" checksum="71C3997018C1887A" modified="2019-01-16" version="1">MAAKEALGLGSDCQVNDESNNPPVELEDFINQNDVSLPPDGGLTAWLQVASAWLIFFNVLGLLNTYGQFQTLYETEILSKNNPSTIAWIGSVQYLISYVTCIFTGPIWDAGHVRFLLVIGTVIMVLGLMMLSLCHEYYQFFLTQAVATGIGFGFVFMPGTAIVPQWFSTRGPFAIGVAATGSSLGAVIYPIMLQRLVPHIGFPWAVRAIAFMVLATMIMSTSMMRLRIAKNTSKRSLIDLKHLGDLPYLLVCTGYFIGFSGLYVFYYYINLYAVDVAGTDSSLAFYLLAMLNAGSFFGRLLPNYIAGTVGVMNVQIIAGVVSSVLAFALLAIKTTTGVIVFTIAYGFASGPFLSLCISVTTGVSADKSTWGTRLGMSYTFMGLGVLIGSPVAGAIIGEGQHKNWTGMILWSGILLMASSIVLIIARIAARGPVLWIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R3I2</accession>
    <name>A0A3D8R3I2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09165</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R3I2"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW68508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="126" mass="13676" checksum="3E78D542ADF40781" modified="2019-01-16" version="1">MASLLNPVITPPMDVLWRSDEHCALMVAEVEVGAIGRIAEPSQYECSGSTPISVFAVASASSKDHVPRADMASPWSSLLDARHGQPFTRLFLTWTSPPTLSTWAASPTSSRQLQNPRGNLWEAEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R3M9</accession>
    <name>A0A3D8R3M9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_09312</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R3M9"/>
    <dbReference type="OrthoDB" id="3172332at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF4">
        <property type="entry name" value="HYPOTHETICAL CONSERVED PROTEIN (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW68655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="473" mass="53687" checksum="B5D7568FCE6A1733" modified="2019-01-16" version="1">MVWIPIFTEEEGRYFSFYCNTTKEELSVFSGKELWGSLVLQTCHHAPSIRKLVVAVGAMSLHVKQAGNTAQKAVREPNPVFSKYHYQFALHQYALAIKLMRESLASGQENIRHVLLWSLLINCFETYNGDHATASNHALWGLKALSYWADTKRYITNQPLRLRSPAPNLVEDDIVHAFNTIDCYLMTARDSRSKESHKQALAVMQDSVTNMPAKFATVQEGKSYWNLILQRFLRFLKTALKPQDEIADLDESHARPLTGNISSGLVDERNRIMKDLLHWDAAFQPVFERSQTPVGRGDRMSTAVLRADTKMWLVTMQVALKSDIEVLYDDHLSTFQEALSLVKTCCEEWELRGIATGPRLTSEVGVIPCLVRIALQCRDRAVRYEALHLLRKYPCQEGIWDSCTCAAAATAVVEFEEASREGGFIPAESRLGVTSLSCLMLHWNQGVLLKDQDMKLSHLHHASQMLFCTEDYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7A5</accession>
    <name>A0A3D8R7A5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW69923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7A5"/>
    <dbReference type="OrthoDB" id="10323246at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW69923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="496" mass="57045" checksum="6538A1C5B40D9543" modified="2019-01-16" version="1">MSSVTSVSQVEIEKRLALLEAKIDELTTASASYGSAERLEGLADTTVHTLQNTENRNEILEKYVQDLDFKCKIMEIDIDVLNSRYNKIQTDNKDLKEQNDKLSALVNNQQDFIRILQNRVCQLKELGDETEQKIAYLDLSLQVLSKYTLGSFQRYIDTFNMNTHIGIQTISNKLIVLERQVARIEGQEEAVLNVQKSLNEFIQEADSAQKTSQNVKALQMSFDRLSHLYESLFKDSNLSKKRLYDLEQASKAGKSDATMEEFSKQVGTLKQSFDGLWDLYQEQHRQSSRTHERLCDLEQSEDICVATNSQISKLCQDRDTMQFKIQKLDTARKSMYEDLKRLLQADSREAEIQESYEALSINFNDLSVQNKDLQERVEDFEELVDDCPGDISQHLKTNSERGEATRKEKLDTLVQRLVGIMKGTTRGTYPEIDIMQERLEALLVPSEHRDQHIEQLYDSVHNVTALTHDGHDWLTKVSLALLERVTELSQSRLGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7U7</accession>
    <name>A0A3D8R7U7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Arginine biosynthesis bifunctional protein ArgJ, mitochondrial</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="10">Glutamate N-acetyltransferase</fullName>
                <shortName evidence="10">GAT</shortName>
                <ecNumber evidence="10">2.3.1.35</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">Ornithine acetyltransferase</fullName>
                <shortName evidence="10">OATase</shortName>
            </alternativeName>
            <alternativeName>
                <fullName evidence="10">Ornithine transacetylase</fullName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="10">Amino-acid acetyltransferase</fullName>
                <ecNumber evidence="10">2.3.1.1</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="10">N-acetylglutamate synthase</fullName>
                <shortName evidence="10">AGS</shortName>
            </alternativeName>
        </domain>
        <component>
            <recommendedName>
                <fullName evidence="10">Arginine biosynthesis bifunctional protein ArgJ alpha chain</fullName>
            </recommendedName>
        </component>
        <component>
            <recommendedName>
                <fullName evidence="10">Arginine biosynthesis bifunctional protein ArgJ beta chain</fullName>
            </recommendedName>
        </component>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_08418</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="2.3.1.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(2)-acetyl-L-ornithine + L-glutamate = N-acetyl-L-glutamate + L-ornithine</text>
            <dbReference type="Rhea" id="RHEA:15349"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:44337"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57805"/>
            <dbReference type="EC" id="2.3.1.35"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine and N-acetyl-L-glutamate from L-glutamate and N(2)-acetyl-L-ornithine (cyclic): step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterodimer of an alpha and a beta chain.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="10">The alpha and beta chains are autoproteolytically processed from a single precursor protein within the mitochondrion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ArgJ family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.35" evidence="10"/>
    <dbReference type="EC" id="2.3.1.1" evidence="10"/>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7U7"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00106"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004042">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004358">
        <property type="term" value="F:L-glutamate N-acetyltransferase activity, acting on acetyl-L-ornithine as donor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006592">
        <property type="term" value="P:ornithine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02152">
        <property type="entry name" value="OAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.70.12:FF:000001">
        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, chloroplastic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.340:FF:000002">
        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2330.10:FF:000001">
        <property type="entry name" value="Arginine biosynthesis bifunctional protein ArgJ, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2330.10">
        <property type="entry name" value="arginine biosynthesis bifunctional protein suprefamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.340">
        <property type="entry name" value="ArgJ beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.70.12">
        <property type="entry name" value="L-amino peptidase D-ALA esterase/amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01106">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002813">
        <property type="entry name" value="Arg_biosynth_ArgJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042195">
        <property type="entry name" value="ArgJ_beta_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00120">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003802">
        <property type="entry name" value="PRK05388.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100">
        <property type="entry name" value="ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23100:SF0">
        <property type="entry name" value="ARGININE BIOSYNTHESIS BIFUNCTIONAL PROTEIN ARGJ, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01960">
        <property type="entry name" value="ArgJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="DmpA/ArgJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 10" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3 10" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_5023258469" description="Arginine biosynthesis bifunctional protein ArgJ alpha chain" evidence="10">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5023258470" description="Arginine biosynthesis bifunctional protein ArgJ beta chain" evidence="10">
        <location>
            <begin position="243"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="474"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="10">
        <location>
            <position position="164"/>
        </location>
    </feature>
    <feature type="site" description="Involved in the stabilization of negative charge on the oxyanion by the formation of the oxyanion hole" evidence="10">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="site" description="Cleavage; by autolysis" evidence="10">
        <location>
            <begin position="242"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW70021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="474" mass="50213" checksum="5C4D8D7E85D9749D" modified="2019-01-16" version="1">MALRGPPSSALNRLIRPAGLQSNISHVRNYSAPLDSTIPAAKQKYIPTSGTYPKGFLVSGTHVGVKATNKSTPDLAFLASETPCAAAAVFTKNKFQAAPVTVSRNMLKRRNNTGVRSIIVNSGCANAVTGKGGMEDAEKMGEEADKCFEQPQDGKGGSSIVMSTGVIGQRLPIQKILRKIPTAYDGLGSSHDHWLTAARAICTTDTFPKLLSRTFTLPSSPSITYSLAGMTKGAGMIHPNMATLLGMIATDAPIAPTLLPSLLTTAVNKSFNSISIDGDTSTNDTVAVLANGAAGGKEITSESSEDHAVFQETLTSFAIDLAKLVVRDGEGATKFVTIRVTEAPSEVGARKIASTIARSPLVKTALYGKDANWGRILCATGYSQISEPGQPINEVPEIVPEKTSVSFIPADGSAELKLLVNGEPESVDEVRAAEILEHEDLEILVRLGGGKEEAVYWTCDYSHEYITINGDYRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R806</accession>
    <name>A0A3D8R806_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R806"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW70179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="108" mass="12162" checksum="0B95E62467B4E439" modified="2019-01-16" version="1">MGRLIRAARRVRPKPSLRTIHFDTAPTLNEASTAISCILNNSVKEDGAVESSRLREEELVATQRKRNNRVGLPYRGIHGEHQAHRPRKVTSTSGLQSTQWHLVQRATS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCA0</accession>
    <name>A0A3D8RCA0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_07706</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RCA0"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="538"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="676"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="204"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="283"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="486"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="326"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="137"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="204"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="283"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW71672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="781" mass="86438" checksum="34FC5B963C9C1837" modified="2019-01-16" version="1">MDANITDNALSSTLQNALILYSNFLQYMQQKRESSLPRHGKEVETTIDVSTEQGLQSQVEASKICLQLQARIVDSVRKWMVSDVIGGGDSAEREECEIPELDADVRKVPHDFAEYMEMAKEQTFIDPFSGKLIEPTTPFSAGPSQSQESGTPASLVILGNGESEDLLAQDDLQGGLKVPLQDLKAFPLTITMLAVKDVLSEPSSRAQSIVQTPQSATPSSHSEDPQDLTPEDSTESPASAAELVPDTFASDVTAALELQAAWDIEDAELRRQFQYALTLQDGSTSSASLAASQPEASRREAEHLPDKLNREALETAFNGPQDDDGLEFVQSLQEEEERRAQEIERAALEAKRLAAEWEREDAELREQAELAKMTLKAEEERTARINAVIRAAQEASSSWAEEEKAGFVQQEEFAREVSQAEEERAQRIQNDILAAQREQSQWENEIREQEEEERRAAEERMKAAAAEAQRVAARIAEEEQRARIEQEKRERAEAEAAERRRQEEIATRNRQIQEETQRQELARRAKEENERRARQADCLACRDPGERSEMAILPCNHAYCGECIAAAFKTASGSRTEFQCCKRIVPVTMASRWLEPTFITSYEALLLERSTPNPRYCSNRSCNKFIPPQHIHGPICIAAFRDNIELVQLLLAAGADANDHAVEAGADVSIAAGNACGITALQGAAIGGYVGIALKLLEAGADSNAPGSAICRRTALEGAAEHGRTDMVKLLFNTGAYRGGLESIEYKKALRLATREGYEVICNLIRDRFEKSAQDDDSGQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCW3</accession>
    <name>A0A3D8RCW3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="16">1.1.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BP5796_07765</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="16"/>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RCW3"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012133">
        <property type="entry name" value="Alpha-hydoxy_acid_DH_FMN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF82">
        <property type="entry name" value="CYTOCHROME B2, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G07200)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000138">
        <property type="entry name" value="Al-hdrx_acd_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 19" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7 19" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="20">
        <location>
            <begin position="11"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="18">
        <location>
            <position position="256"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="90"/>
            <end position="92"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>glyoxylate</name>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <begin position="313"/>
            <end position="314"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR000138-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RDW71731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="386" mass="42047" checksum="53FDDF7C5D70D248" modified="2019-01-16" version="1">MADSSEEDIETEMQALLNLDEIEAVATKKISHRAWAYYYSAGDDLISKKLNSQVYKAILLRPRVFIDCTKCDTRTTLLGHQLGTPLYVSPAAMARLGHPAGERGIAQGIASFGALQVISNFASMTPAQIVTGAAPGQKFGWQLYVSQKRATSEKMLATINAMGDRMVCVCLTLDSPVLGKREDHFRLDVDLQKPAVAPGWMAPGGTALDLTWRDTLAWLARHTTLPIILKGIQTHEDAYLAMQCAPQVRGIILSNHGGRSLDTAPPAVHTLLEIRKYCPEVFERIEVWVDGGIKRGTDVVKALCLGAKAVGIGRAALFGLGAGGPQGVERTFEILQAEIETCMRLLGVEKISELGPQYINSKAVEMDIFDGQEGKEELRSWAKANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RI97</accession>
    <name>A0A3D8RI97_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_07221</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Polynucleotide 5'-kinase involved in rRNA processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Clp1 family. NOL9/GRC3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RI97"/>
    <dbReference type="OrthoDB" id="4054781at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000448">
        <property type="term" value="P:cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001156">
        <property type="entry name" value="Polynucleotide 5-hydroxyl-kinase grc3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF3">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-HYDROXYL-KINASE NOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Clp1 P-loop" evidence="13">
        <location>
            <begin position="281"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="304"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="62"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW73779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="764" mass="83471" checksum="F88B17782F232AA2" modified="2019-01-16" version="1">MSSSKRRKIEASSEKAPLSALAARRALQAEAEGKGPSSQLTDPGVRPFEEPREDNRFAALRSLSSRNDNKNESSPVTAGVPSQSSKTTRKDRITELDPSDNYSPSASRGESPEAPQERPSIILSTFKPGQGSRLVILGHFEMLVSEGQVTLLGASLKKSPTTYRVYASLSHSLPVIRVSSDDVNGAMISLRQCDDGLPVLEQLSPLFGKLWNDRPGSLSSEPRSLVTGHKQSSSFQILFSSEEGPKKAYLQPVISPPEWNAALARLSIRNDQTIPMILICGPKSSGKSTFAKLLSNKLLTMDKKRSSESSHDSQSGIAVLDLDPGQPEYSTPGQLSLLHLLEPNFGPPYTHPIPSNMSHIIRAHTVAAITPSLDPALYMSCALDLFTHYKDHLSKYPGCPLVINTAGWVLGTGLEILEELIFRIKPTEVVYMSQEGPLEVTKSLRDAVKKSPLLELPSQISEFTSRTAAHLRTMQYMSYFHMNPYDDNGLTWSNTPLTSVPPWEIDYCGQGGILGIMCYGEQPPADLLLDAINGSMVAIVVVDDMAAIPGWKPADQESTNGVTTGRADPDLEMQMDDIDIRAFDDKSYHSQDLTQPLIVRTPHEALPYFNPSNTITLDPRYSNTIGLALIRGIDIPHQRLQILTPIPASEIERLNSAGKPIVLVSGKFDTPGWAYTEDLIQRTLREKRVKEVKDAREARARKKRGAAVPGGGVVDTDEDVTVLGDATGTVDAPWVERLEGSQGRGVGAKVWRVRRDLGKSDGGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RNW1</accession>
    <name>A0A3D8RNW1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_06516</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RNW1"/>
    <dbReference type="OrthoDB" id="47494at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF6">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="179"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW75695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="257" mass="28610" checksum="2796E42FD01126DE" modified="2019-01-16" version="1">MDDLPPLETLGTTYNLNLPAEGATFDQDMNDKWCLKSTPETPLIGADRARLRQWLLTNIEVEWDRKFTHYQEKYDGVIAFFEDGSSVKGIILIGADGIGSRVRQQLLPDIGPKHLLMVVIVGQLTATQEHKTTEEPSYWTTTASEEALHMDVINHLDGLHTSFTEPICATTVEGILHPPLQMRDMVPPTLPKGWVSLLGNAVQPMVPFRGEGGNMAMKDGMSLARTLEQCTEQNIKDVLKSYEAEMSERATKSVLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPB7</accession>
    <name>A0A3D8RPB7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="7 8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_06753</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the PPP phosphatase family. PP-Z subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="7 8"/>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPB7"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000006">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011159">
        <property type="entry name" value="PPPtase_PPZ/Ppq1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF484">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PP-Z1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000909">
        <property type="entry name" value="PPPtase_PPZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="10">
        <location>
            <begin position="331"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="516"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="56"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="157"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="579"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW75932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="650" mass="70956" checksum="984F7C81475953DD" modified="2019-01-16" version="1">MGNQSSKPSGGSSTPKRTPSLASLNKDRLESYPSFSKSDTKESMKSFTGAFRSKIPSRTDSPRNSTTTLTPASDGDKSDAESIKSTKSNQSARARRRNGEWKTPPGTPITRSKSPRPPAKQTSLDGQPPPSPVSAAAMTNGHHDVSAAQRSGEVDNVSDQPPSGATNPHTHSQKAGASILVKRENTINPIAKIIPQIDDGTGISGSNVAMGELNDSDLDDYIKRLLDAGYAGKNQKAVCLKIAEITAICARVREIFLEQPPLIELEAPVKIVGDIHGQYSDLIRMFEMCGFPPSSNFLFLGDYVDRGKNSLETMLLLMCYKIKYPENFFLLRGNHECANVTRVYGFYDECKRRCNTKVWKTFVDTFNTLPIAAIVAGKIFCVHGGLSPALKHMDDIRNIARPTDVPDYGLLNDLLWSDPADQEKDWAASERGVSYSFGKRVIQEFLARHDFDLVCRAHMVVEDGYEFFEDRVLVTVFSAPNYCGEFDNYGAVMSVSLELLCSFELLKPLDSSALKSQMKKSRNKRNSMINSPPVSNRAAVNGRDFDISPSSMGDLDGILGETPAESSMSKVKNSRHGSIDTQQSASNFSESTLVGNDTRPNGRSNSAPTLVSTEDAASRTSNEAASARPISLDTLKAIYDDTDDWVNGAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPV2</accession>
    <name>A0A3D8RPV2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxidoreductase-5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_06821</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPV2"/>
    <dbReference type="OrthoDB" id="3360610at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004493">
        <property type="term" value="F:methylmalonyl-CoA epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046491">
        <property type="term" value="P:L-methylmalonyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07267">
        <property type="entry name" value="THT_Oxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000034">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000039">
        <property type="entry name" value="Trihydroxytoluene oxygenase (AFU_orthologue AFUA_8G02470)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051785">
        <property type="entry name" value="MMCE/EMCE_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048">
        <property type="entry name" value="METHYLMALONYL-COA EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048:SF3">
        <property type="entry name" value="METHYLMALONYL-COA EPIMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="175"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW76000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="330" mass="37836" checksum="1CD60636995262F3" modified="2019-01-16" version="1">MTAVTEPKKIMLVKPAHVYYTHVDLESAHAFLLDFGFAEEKRVGSKIYYRGYGPDPFVYCASQGDKTEFGGVAFVVESEDDLKLASQTIPGASEVYTLEDTPGGGKCVTFKDPVDGFPFHLVWGQKERAGKREIDGKDELPNGNPLHLAFNFPEDKQRPAGKFQRFKKAPAPVYKLGHVGVCVTNFPKTFEFYTSRFNFYPSDLLHKPDSKQDFNTFCRLDRGSELVDHHCFFFFEGPKYHVHHSSFETHDFDTQVLGHDWLRHKGYENCWGVGRHIMGSQIFDYWFDASKFILEHYVDGDLLDNTYPTQKKAASHDGIHVWGMYQELLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RQ42</accession>
    <name>A0A3D8RQ42_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_06889</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RQ42"/>
    <dbReference type="OrthoDB" id="1306014at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20908">
        <property type="entry name" value="SUF4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000354">
        <property type="entry name" value="C2H2 finger domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003656">
        <property type="entry name" value="Znf_BED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215:SF0">
        <property type="entry name" value="BUB3-INTERACTING AND GLEBS MOTIF-CONTAINING PROTEIN ZNF207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215">
        <property type="entry name" value="ZINC FINGER PROTEIN 207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50808">
        <property type="entry name" value="ZF_BED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="BED-type" evidence="9">
        <location>
            <begin position="14"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="118"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="123"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="194"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="285"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="321"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="407"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="425"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW76068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="491" mass="52094" checksum="4F96C410BF596A47" modified="2019-01-16" version="1">MVGKKKRGHPDIEELLARPWCYYCERDFDDLKILISHQKAKHFKCERCGRRLNTAGGLSVHMNQVHKETLASVDNSLPNRQGLEVEIFGMEGIPEDVVQAHNQRIIAGFYQAEAERRAATGNPGPGAQGGGQSKKPKFESPADLKKRLAEHKARKAEQAAAGNSGGNTPLDYNGQSPMGQSPGAFNGSPYAPPATTGASQGAGYGSYSQEPYAQPATAYQQPYNQQPPYSNAQTPSYQAQYSPPQQYPAPQSFQAGGYQQPPASYPGGPPPTYAGSPPGSFNGYQPPPANTPPGLPSRPPSLPPAPGLPQRPSFGAPAVPPYQMQQMHQGQQGSPPPFPGQGAPGTWGANGWNGQDQNSAMSSAYSPYPTNSSAPQTGGGDDIDEIIRMAEAGIKPPKKEDLATATAEPVQAKEPAPAVAASEATEAKSDALAEKKAKKDKPMRMIYSDNDVSPEEKMSKMPRYAFVPDGKADTTLVDATSQPGVAGTVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RV61</accession>
    <name>A0A3D8RV61_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_05720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glyoxalase I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW77868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RV61"/>
    <dbReference type="OrthoDB" id="5371818at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050383">
        <property type="entry name" value="GlyoxalaseI/FosfomycinResist"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21366:SF14">
        <property type="entry name" value="GLYOXALASE DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21366">
        <property type="entry name" value="GLYOXALASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="2">
        <location>
            <begin position="17"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW77868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="205" mass="23007" checksum="8598232630FA6215" modified="2019-01-16" version="1">MATNFDLPRDKVMSPKSLAHVVLRTSNLEAMAKFYADFLGATIVFQNDYICFLAYDEEHHRIALIGASGTMPKVPGSCGLEHIAFTYSSIADLALAYRQRKSRGFLPIWRVNHGPTTSIYYSDLDGNQIETQVDNFDDMNDATIFMNSKLFDNNPIGYDFDPESLIERLQAGESEASIKKRIEVGSRGFNDLPMANLDFYKPAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWM2</accession>
    <name>A0A3D8RWM2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_06250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWM2"/>
    <dbReference type="OrthoDB" id="272624at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001156">
        <property type="term" value="F:TFIIIC-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070898">
        <property type="term" value="P:RNA polymerase III preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039467">
        <property type="entry name" value="TFIIIB_B''_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929:SF0">
        <property type="entry name" value="TRANSCRIPTION FACTOR TFIIIB COMPONENT B'' HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15963">
        <property type="entry name" value="Myb_DNA-bind_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="458"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW78398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="630" mass="68999" checksum="A0416ACDA4E411AC" modified="2019-01-16" version="1">MSSMIKKKGAFAKAFKPKAPQARRPVPTASTSTTTRPSVEHQQQQQLQSAAPIIVASLQHVVPDSQENDLPNVTGPANTQQTSSNATTEKSRLAASDNNLKRKTTHYEDVSAEDSSEIPAKRTRIDAHSQATATARPEQSTLIETANPTQQVSETTIPSQKTATSVSQPPRQINITRAQSPLEQIERSQQSNASTSEPIQEQTQEPTTNGHVTRENTQETQPDVDLSAIGPGQANRGSHIVPSASLNADGTSGELLEERDGDSATEKATGTRRKMIQQQEGDVRATIEIQLHRPKRATGEKRPRKKKEGEKKKRQRAVTPEGAEEESLPAGITMADLCKDLKIGKKFSKHDEIRKKDQEKKIKAKLGQGLSDSVDAEGNQTAEGASSTARPNSTPIAQPVARQTVGMQIVDGNIVLDQRTLLHDRHKEAAQDRQDFEIIEENDFTSLTTSGTYMKKVRAMAWSPSDVELFYKCLRSYGTDFQMIATHFPGRNRRQIKLKFNAEEKAAPARITKALIGTPEPIDLEEHQTRAGKVYEEVADIEAEERELEEKAKVEEDAERAKKDAEIRQQKAQITGRGGDSAKENDEADGDASAAPRSKKKGAAAKKKAKPNKNFGGGGEEVEVLGTVER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWS4</accession>
    <name>A0A3D8RWS4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rhamnogalacturonan endolyase</fullName>
            <ecNumber evidence="4">4.2.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_06103</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endotype eliminative cleavage of L-alpha-rhamnopyranosyl-(1-&gt;4)-alpha-D-galactopyranosyluronic acid bonds of rhamnogalacturonan I domains in ramified hairy regions of pectin leaving L-rhamnopyranose at the reducing end and 4-deoxy-4,5-unsaturated D-galactopyranosyluronic acid at the non-reducing end.</text>
            <dbReference type="EC" id="4.2.2.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the polysaccharide lyase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.23" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWS4"/>
    <dbReference type="OrthoDB" id="1179585at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102210">
        <property type="term" value="F:rhamnogalacturonan endolyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10316">
        <property type="entry name" value="RGL4_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10320">
        <property type="entry name" value="RGL4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051850">
        <property type="entry name" value="Polysacch_Lyase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029413">
        <property type="entry name" value="RG-lyase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029411">
        <property type="entry name" value="RG-lyase_III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32018:SF1">
        <property type="entry name" value="RHAMNOGALACTURONAN ENDOLYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32018">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14683">
        <property type="entry name" value="CBM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14686">
        <property type="entry name" value="fn3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017696441" description="rhamnogalacturonan endolyase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="12">
        <location>
            <begin position="310"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="11">
        <location>
            <begin position="405"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW78251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="563" mass="62316" checksum="9DBA59463C182353" modified="2019-01-16" version="1">MKTFSLCASLLVATTHAAANATRSSGPFLKSLDSGTGWIIGNDLWNITIGEIYGKSLFYQGQDLIGNAVGHYSGYDGETNFVWTSASVYENNSEYLDVVFSATEVDLHWVIYPELAGAYQYLVNKALPTLAVLRTLYRLDNTTFTHGRTNVKDDVLPPYADILAATKVQDETWQRADGTYITKYDWSAFVREIDFHGVYGDSFGSWYIRPGRDYINGDHLKQELMVHRESATGDAVELNVIHGSHFQVTSSATFPVGKTWGPWLWYLNNGSREDASSRAQQEFAAWPYTFLNTTGYQSRGRVSGRLVLSDGRPASGAAVFLGDNQSNISTLDQGTDYYYAGYADIEGYFNLDNVRTAEYALYAWSNGGDLSDVATTFSQNDIVVGDSEALALGDLVWSVKTRERILQIGDLDRKALGFHNGGAPRQHGLVAQSPANLTYIVGESNVSDWYYGQSALGSWTILFDLPEASNRSATLAISLAGYSKSSDLVIGVNGQPVSQLLSADLLSDPALYRSGTTAGEWHYYEFHVDSGVLQAGWNNVVFQVTRYTLWRGFLWDSVFLDWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S258</accession>
    <name>A0A3D8S258_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Peptide transporter PTR2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_05063</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S258"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="433"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="479"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="515"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="544"/>
            <end position="565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW80365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="602" mass="64642" checksum="88E0962B889ECB9F" modified="2019-01-16" version="1">MTEDGVMDDAFTEAPAPIVAGLDEEHHVTLAPVHDSGMMDRNGHIMPTEEELATLPRIAGTMPVSAYLLCGVEFAERASYYGCKQVFKNFIRAPLPAGGNGAGATARGTQDTAGALGKGTVIASAMTDAFTFLAYALPIFGGWIADKKWGRFKTICIGVGICGVAHVIMIISAIPSIIQSGRAIGPFALSLYMLAVGAALFKPNIAPTVLDQNPHRKAHVVTNKNGQKVIIDPEATSESIMLWFYLLINIGAFLGVATAYLAKYVGFWASYLVPGIIYFLLPVFLILVNKNLVKLPPGGSALGDFISVNILCLRKAGLRGFGRKGFFERAKPSWLAMNGDNRTVNWDDKFVEDVRRTMAACAIFLFFPIAQINDGGLGAAANALSASLTSNGVPNDVLDNLNPLAIIVLIPIMNQGVYPLLRKLGIRFGPIARMTTGFLIASIGASSYAILQHFVYKTSPCGNHASTCDIGTGVSPLSLWLYAIPTVVTAFSEVFINVTAYGIAYSRAPPNMKGFVMAISLFMTAISTAISLATANAIQDPYLVWTFAAPVIIGFVSAIVFWFLFKHLDNEEFFVEEDEHRASATASSLDEESIGEKKAIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S277</accession>
    <name>A0A3D8S277_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_05083</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WHI5/NRM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S277"/>
    <dbReference type="OrthoDB" id="2359117at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039198">
        <property type="entry name" value="Srl3/Whi5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013734">
        <property type="entry name" value="TF_Nrm1/Whi5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28246">
        <property type="entry name" value="G1-SPECIFIC TRANSCRIPTIONAL REPRESSOR WHI5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28246:SF1">
        <property type="entry name" value="G1-SPECIFIC TRANSCRIPTIONAL REPRESSOR WHI5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08528">
        <property type="entry name" value="Whi5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0678">Repressor</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="166"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="243"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="313"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="496"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="96"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="367"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="392"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="415"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="499"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW80385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="526" mass="57315" checksum="38484F18FB9344A8" modified="2019-01-16" version="1">MDVHALATAALSQVTQSQSSTQDRDRDHDPDPVKVAASRSSPNDATAATGVRVEQPAVKNPIDNRRINYQPSPEMSVESQQYVEDVPNHQVGAAFPSTSSDNSQYTTDGHDTASTPPTSDGFSSQSTIPDTHLSQLSQLSQLAAARQPLAQSTAARFDVDIMTAGSKRTADGQVKPTMSKSPTSPNGPYKRGHSRNTSTFSNASSTTSRIGELSSELRTRLSYAMVKVNNGWQSNSIDEVESLASQSGSPTSSNSTLHGRRNLITSPRAVMANAQNQDTTAMRRTSPIPRTNTDFDLYPNIHQPSRTYESFWQDHSSRVQQRHPIHSPAMSPPAPKLSLAPPADIRPTSHSRRSDSKFSRPPTIPGQSRSDLSQSSNQSVHTPRTPNRDFNENSVQTPTQKSLREQDAIETLVFMSSPGNSGNMGNGMPPLVPRRSQMSPAQTSPLKHEFGSQSRGSQGRRVNFEKIDGISNHLGGYNSGRSKMNTKTRPEDIDKMLDEMGDSSSDEDNVVLSKYSSPRRVTAGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2E6</accession>
    <name>A0A3D8S2E6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_05134</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2E6"/>
    <dbReference type="OrthoDB" id="301415at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056337">
        <property type="entry name" value="LHD_YVC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052971">
        <property type="entry name" value="TRP_calcium_channel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056336">
        <property type="entry name" value="YVC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859:SF5">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35859">
        <property type="entry name" value="NONSELECTIVE CATION CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23190">
        <property type="entry name" value="LHD_TRPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23317">
        <property type="entry name" value="YVC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="373"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="433"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="488"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="520"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="YVC1 N-terminal linker helical" evidence="3">
        <location>
            <begin position="44"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium channel YVC1-like C-terminal transmembrane" evidence="4">
        <location>
            <begin position="245"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="588"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW80436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="625" mass="71739" checksum="9DEDBEECD75F08DA" modified="2019-01-16" version="1">MVQWKKLFGLDGSADRHMWRDEARRLLPTYHEDGIPSAIPAPQVTKVALRLRYLIEQAVPCELEEDCITKAHSHVITPSVVEAAKNAGEGEYNACVVYALLVNKRWFKKQAMLELWDADLHNVRATACEVIAKALIEKEDDMDYLLQDVLLKRYSIMIDGEQTAPANVIERAVDLHALRVTGSSGYQKCVNYLWRGWLVQDENDPSRFVDYKKKDNISYWSHVHPDRMRAPVYQNATQIIFSVVYLALYTGAINTVNPSGDLDVVEGLLYIFTLGFMCDEVSKLWKIGRFYIGFWNVFNVCLYALLCTSLVTRFIALSYPIDNDSRSSYNELSYNFLAFSAPMFWMRLLLYLDSIRFFGAMLVVLKVMMKESLIFFALLIVIVVGFLQAFIGMDNADNKSTATKFILQAMANAVMQSPDFDGFDHFAPPFGIILYYVFTFLIMVVLLNILIALYNSAYEDITDNAIDEYLALFAQKTMQFVRAPDENVFIAPLNLIEIFCLVLPLEWWMPRKAYAKLNDYVMGAIYSPLLFIAAWFETRSARMVRSNRKRGEEDDDTTEEWEQMIGECDFEAEGWDKKVKSVVPNVEEDRATLEVRELRKEVHELKTLLLKLVEEKGKGKAENGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2N0</accession>
    <name>A0A3D8S2N0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription factor SWI6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_05250</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Transcription factor that plays a role downstream of the MCK1-MKK2-MPS1 cascade. Required for hyphal morphogenesis and pathogenicity. Is an important oxidative stress response regulator and plays a positive role in the regulation of extracellular peroxidases.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2N0"/>
    <dbReference type="OrthoDB" id="6718656at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.260.10:FF:000001">
        <property type="entry name" value="APSES transcription factor (MbpA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.20:FF:000365">
        <property type="entry name" value="Start control protein cdc10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF3">
        <property type="entry name" value="CHROMO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0183">Conidiation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0749">Sporulation</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="10">
        <location>
            <begin position="89"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="435"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="576"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="253"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="687"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="787"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="260"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00059984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00073460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW80552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="871" mass="95606" checksum="28191C880E78B971" modified="2019-01-16" version="1">MASATLTTNPQPLANTSSSRQNHLNHQPSYPSASGAYDEDLTSNPRTNMSFSMSQGSQGGGLMLQPGGGSFRQYPENNGMHRGNPSPQIYSAVYSGVDVYEMEVNSIAVMRRRKDSWLNATQILKVAGIEKGKRTKILEKEILTGEYEKVQGGYGKYQGTWIKFDRGLEFCKQYGVEELLRPLLTYDMGQDGGVAGRGGIDTPTKEQAMAAQRKRLYNSGMDSRASSQSGTFFKNISSTASHAVAAISKARFDSPGVRSGNLQRPASFSRQSSQQYLGSQESVFPGGSQQSMQSFTSDTSFSAQPHPSYATQSNGPQYSFQGREGEFPEPPRKRMRPSPGINDSQQTLDGALYDQSMREPSPTEPNESFVYTQQLQTMEQGDEYPNTLAPLSLPSEAKKSILMSLFTDPSRTNFSTHEAFTTLSDEDLDVPIDTSLHTALHWAATLARIPLLKALIRRGASIYRVNGAGETALMRACVVTNNLDMGSFPDLLELLGPIIELRDNRGRTVLHHIAVTSAVKGRSQASKYYLESLLEFVVRQGSAPNSQQSFGGPSSTRTTMGIGRFMSEMVNVQDNSGDTALNLAARIGNRSIISQLLEVGADAGIPNRSNLCPCDFGVGDPVEVTDRAGVYGSPEKTAAEREKSGDIITSIASLLANIEKEFTKEMDTKQAVIDTYHNQLRESSAELGTQRRRLEAVQARIKEIQERKVKIANLRRAKEEEGHTTAQMLQDRGQTIGQVEMQLGDADKGFALIPGSIPNDDLANLNMNQPQGLDQSQRAILSTLPPAAVLRAHINAYTTNNDRLEERVKELKSKSTDLANKYRRIISLCTSVEESKVDGHLDNLMRAVESEQNDVELGRVRDFLQRVDGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2V3</accession>
    <name>A0A3D8S2V3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mitotic checkpoint protein BUB3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_05331</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2V3"/>
    <dbReference type="OrthoDB" id="10262475at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000725">
        <property type="entry name" value="Nuclear pore complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="99"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="261"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW80633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="38851" checksum="F0F6876C750314DD" modified="2019-01-16" version="1">MAPAIQFELSEPPTDAISSLAYAPESSTRLLVASWDRNVYLYDTTGGGEESSGTLIRKYEHRAPVLDVCYGQDDNEAYTAGMDWQVKRINLETGEQTIMSAHEAPVKSVVFSKEHSLLVSASWDSTLHFHDISNPDREHTTINLPAKPHSLSITATKLVVAMSSRLLYIYDLQTTTMITSQANGATTELQPWQQRESSLKFMTRAVACMPNDAGYASSSIEGRVAVEWFDPSTESQARKYAFKCHRQPAPEGDGTDIVYPVNALAFHPFHGTFASGGGDGVVALWDAVAKRRIRQYQKYTQSVAALAFSSDGKYLAVGVCPGFENGQEDYNGEGETKVFIRELGENEAKGKGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3B7</accession>
    <name>A0A3D8S3B7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_05466</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3B7"/>
    <dbReference type="OrthoDB" id="441210at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000795">
        <property type="term" value="C:synaptonemal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042448">
        <property type="entry name" value="CCNB1IP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14305">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CCNB1IP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14305:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE CCNB1IP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW80768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="336" mass="37217" checksum="7D4DADB37474A764" modified="2019-01-16" version="1">MNLKPTEDYKTIALSGLTPSVIVECASRALGFWTYQATQEMFASSPLAFLIDTDPGHRVYQGYLSRNLTEKYGTLHAQMEKVINDADAEVVDMALETENLRHQNENISQALREKSRAFLQLQELYDKQKGQERVDQVQHAASTAVEQTIQASGVANSFVDRMRYQNNVPRPASPPLFSAPSFHNKERNPNLPEPNSHNRHQAWAEYASHGSIAQERQPPFNRPQRFPGIGEPNQQMRPPPPRMNDSAGPSYLGNRATPRQTPLRSISSNSINGLSGYGMSAGLKVSNPTSAAQSGYRPISKPRVVLRPPTGFTKTRPPFGPVAASTNTIPYGNGYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3G1</accession>
    <name>A0A3D8S3G1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_05329</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the histone H4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3G1"/>
    <dbReference type="OrthoDB" id="3919494at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000012">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="12">
        <location>
            <begin position="96"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW80631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="173" mass="18673" checksum="D67EB4C32ACACB2D" modified="2019-01-16" version="1">MSPLLSSASSRRVMSSGASGSARAATAGPSRPATGIFGHARPTLGGKGVAGQTGQFGFGRGKGARGIGAGVAKTFRRQRKLLKDNIQGITKSDIRRMARRGGVKRISADIYDEMRTAMKSYLERILHDCVAIVDGMHRKTVTVTDIIFVLRRQGRPIYGFDKDTYSDKKKITA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3T6</accession>
    <name>A0A3D8S3T6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_05459</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3T6"/>
    <dbReference type="OrthoDB" id="2095648at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF2">
        <property type="entry name" value="F-BOX AND WD DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11400)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00256">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="120"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="669"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="733"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="907"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1013"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1083"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="745"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1013"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1088"/>
            <end position="1101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW80761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1176" mass="128682" checksum="26602702B97CC8F8" modified="2019-01-16" version="1">MQPAPAESSIRASDTATTAETSNPTQHGSRPDRLPSADSHSFVHDWRSESEEDRTRDASRERLLDPLLRLSVGDKQEKRPKPSFQRISEYENALSPSPPRKQNDGPAFKVVKKKGNRLDGPQLENFPNEVLTHILSHLPAASLSAVSLVSRRFYNLVTTPHAWRIAFSRFFPGQDAIEGVPLSQLNRRGSDLEERDTLRAEQRLFTRLIALASWRSEYILRTRLLRSLARGKPAQIAPGHGASSRSQSAANNSNAVVTYNSQLFSAINHIHAVFNDGKKSPRFIHGTDESGTACTSDPNIGKIDNWGLSDPQSLPQFADLFAGDAPYGAGEGPVGLPNTMDVSQPYGLIYGEGFPGGQAYYRSSDEMRGRFLAQMNDHSDPALGIPKVPQLTEAISTVWIAKSNTVPSMTEGLIGIMTGSTFGIVTAYSLGGDYSQGRRLGKGQVTAKWILSPGVPIISIAIDEAYNEKRKAARRIWAVALNALGEVFYLTVPPSSPTIDAKLDDFTSSNLAWEAGRTTYWALSEPTRRVARDDPYHEAEIHGSYSPRSSSKEMNLSREQIVAETLEVQTFLKFRPSHFRKWCEGWDMRRRLEVDFAGDDGHRAGESIFVLRCGIACPAEIKRFTRWHSKQAPFEEYPQPKTPPTVSQAAPMASLFGGGKVIMPPNTSSSVKSPIIPESPPVKGRPSTLVEEWRTSSLSLKDLPGMEITTSAIDMSTFAVLTVSEDPLRTVNGNSSVSSPFGTPASDASSLSSSEADIPGHRARFLAIGTKTGTIVMWNMRGPQSANPTVVNDLHPIRTIYTDSPQISCLAVSALYLVHGGNDGLVQAWDPLASALEPIRTLNSRFASRARRRLVQAEASIHGVGINLYAAGAIVIDTDPTILRGMVSLGTHLRYWSYSSSAADQYSSKKRKVRRSSERGHNGGPDRFTNTGRGALMDYIATEQEELKAEKHRRAKEEARLAGRFGVGLGGLTEEEALRYAELISAETYQRDTEQRISDAGYHVDSPLVESSSTHSTWTSETVTPEGSVVASSTSPRVELKTDDELNHDIEEAIRLSLLEGEDTITGPPLVSPEYNIPITYRQKRSGRSVSTSPSSSQVPRSRIKAMSSSQHATNKPIGGVAADDLDFALQLSLAEENSRLELVAAEGEQKHELYALEDEFPSLNPKAKGKEKVAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SA48</accession>
    <name>A0A3D8SA48_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_04718</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SA48"/>
    <dbReference type="OrthoDB" id="2405944at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053226">
        <property type="entry name" value="Pyrrolopyrazine_biosynth_F"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48419:SF1">
        <property type="entry name" value="SULFOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW83227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="40011" checksum="E5E2312BEDC8E922" modified="2019-01-16" version="1">MSSKPIFVATHPRACSTAFERVFMTRTDILNCVHEPFGDAFYFGPERLSTRYEDDEKARQESGFEHSTFKTIFERIEKEHEEGKRLFIKDITHYLVPPEGKPATIAPSLGGQRVKKGVGTNGTTNGANGVNGVHTTPYPYGTEAEPGNPSVVPASILKQFHFTFLIRHPRSSIPSYWRCTIPPLDKVTGFYDFMPSEAGYDELRRVFDFLRTEQQIGPTHAGEHEGLKNDEVSITVIDADDLLNDPEGIIKAYCKEVGIDYKDDMLCWDTEEDHQRAKDAFEKWRGFHDDAIESTSLKPRDASHKKKVKTVDEENKEWKEKYGEEAQKCIRACVDANIPDYEHLKRFALKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SA61</accession>
    <name>A0A3D8SA61_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pyruvate dehydrogenase protein x component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_04728</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SA61"/>
    <dbReference type="OrthoDB" id="202158at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004742">
        <property type="term" value="F:dihydrolipoyllysine-residue acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06849">
        <property type="entry name" value="lipoyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000010">
        <property type="entry name" value="Acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003016">
        <property type="entry name" value="2-oxoA_DH_lipoyl-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045257">
        <property type="entry name" value="E2/Pdx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYL/SUCCINYL-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23151:SF82">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE COMPLEX PROTEIN X COMPONENT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00189">
        <property type="entry name" value="LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Lipoyl-binding" evidence="5">
        <location>
            <begin position="37"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="6">
        <location>
            <begin position="176"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="118"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="151"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW83237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="433" mass="45841" checksum="67652E96B32C6A4E" modified="2019-01-16" version="1">MASFASACRLSARLTSRQLRQDATARGFRTSAAYLAAQNFTMPALSPTMTEGNIAKWAVKEGDSFSAGDVLLEIETDKASMDVEAQDDGIMAKITAPDGTKAIKVGTRIGVIAEQGDDLSTLEIPHEESVSSPSEGAKSTSNGKSEAQSQAPTTPKSSGSKPAKKASSKAEKQTRPLLPSVQALMHQHGLPESAVDEMTPSGPNNRLLKGDVLAYLGSIADSYPSELSTKLEKLSHLDLSNIKTVAPPAPKAPKPAESAAITEPVIENLEVALPISMASVLEVQKRIQTTLGIFMPISTFIARAADVANDDLPRSKSYKPSADELFNQILGLDKVSQSGVRGDFMPQIIALPPSSLSTRSVKGPAKKVDIIDVLSRKSRPVAPKINASGALPGVSANTNIFSLTVPKGDEKRAQVFLERVKAVLEVEPGRLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAP5</accession>
    <name>A0A3D8SAP5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_04712</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAP5"/>
    <dbReference type="OrthoDB" id="60822at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011893">
        <property type="entry name" value="Selenoprotein_Rdx-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36417">
        <property type="entry name" value="SELENOPROTEIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G05220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36417:SF2">
        <property type="entry name" value="SELENOPROTEIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G05220)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10262">
        <property type="entry name" value="Rdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="115"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="115"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW83221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="256" mass="27744" checksum="4AA06F7E8D37F58F" modified="2019-01-16" version="1">MPPPLSGHLLPWIPWSPVSSDLTEWASFAQELLSTFSTSLGEVALQPSTGGTFTIHLYHLPTDANVLGEISLDTNVEKLPLKVQKSLLWDRKTEGGFPETKELKRRVRDIIDPARNLGHVDRVHNTTTSTPPTQTPDSQELPQQQRLEPSDSFDSETGANLYAPPRTVVELAPGQANLGIERTSYGEAIMAGVPIPGPISHLAKFEEGMGEAPTKKRRLVQTEDTETGGSGGGEKSQKVEEGGEGVCKPGDECWEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SGB6</accession>
    <name>A0A3D8SGB6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_03667</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SGB6"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="264"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW85342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="33232" checksum="35D070C871BB64AD" modified="2019-01-16" version="1">MYWTSNWWSSLGIFGLEVYSFLPETLRVLVKNGSVQPSAIYRPLVPFLGHGKRDPAQKSSKAGRPKFANPFLLLIYPDVAITLLFTGIVYAVNYTITASISSAFAVTYPYLSATDIGICYLSTGGGMLIGSTITGKLLDREYRIIKEKLYDNNLENEDVATIDFPIEKARLRTMPLYLLVFCVSVFAWGWSLERKLSIVAPLLFQVLLGFTSISILNTTMTLMIDILPSQGSSVTACTNLVRCSLAAVLVSVIDKITAVMGFGWAYILLGCICLALLPLMVVEIKIGPRFRRKRESLAEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SGE3</accession>
    <name>A0A3D8SGE3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_03744</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SGE3"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="459"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="41"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW85419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="524" mass="57550" checksum="7F3F52D84F51BEAB" modified="2019-01-16" version="1">MKYDQESSATATHVDLSDAHAPLPETLHWWQQPNLRNLYLLMPFLFLGSTTLGYDGSLVNGLQTMPAWQNFFGHPTGGSLGIIGAMPGFGGLAVLPFAPYIVDNLGRRAGVGLGCLVVLFGALLQAFPKAGDPTPMYLAGRFFIGFGGNLTNAACPLLIAEISHPRHRGRATTIYNTLWYLGAIISAWVGYGALVHITGDAQWRLPTGLQCVMPGILLLCLWFVPESPRYLISKEKDDEALAFLLKYHGDCGQESFARWEYSEIRETLHMEKAAAANSGWHELVRTPGNRKRCFLIICTAIFSQCSGNGLVSYYLSSILNTIGITDSKNQSLINGGLTIWSWLVSLGFAFAVDKIGRRTLFLVAGIGMLITFSIWTACSAIYAQNGSTGAGSAVLAMIFLFYGAAGLAWPGLTVSYTVEILPYNIRAKGLTLCFVFTQLAGIFNQYVNPIGLQNLQWKFYFVYIAVLVIECLVIFFFYVETKGPTLEEIALLFDGEDANVMSEPISEKIPHISEQGHIETVDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SGL7</accession>
    <name>A0A3D8SGL7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_03824</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SGL7"/>
    <dbReference type="OrthoDB" id="3564848at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF1">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="266"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="427"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="498"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="427"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="452"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="498"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW85499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="827" mass="93635" checksum="56E1FEBEA58F73E6" modified="2019-01-16" version="1">MPCCMDFMARGRCRILDKGGVCELNHDLDLYNEARKIGRESIQLCADYIRHGQCRFGARCRHIHSNELRQAKVARDIVKGEEREVTRKAQAFARGQEAIAKSITKPLPQIMIRVAATAKMDGDHGNPPSYPPLASVAIRGGSVTYSSSTDSPSISKATKSIILPKYQPDISFETFFQGSFKPRITPKAKQSQPAMTEITESIRSVEKPEPEIQRPPSTATSNLLALKQQNSMATLDQHTSANSSVPSVAEQNMLPRPTARQTANVPVSNEICWYFINKRCKYGRGCPRYHDAVLRSEKRNELEEKQRSKHGNSNTKLGMRVAVDAAVEPIQQPPSAHFTPVQEQKCVKPAANIQTRNKALPKNYRPENQRKVAASAGHCTQIDMEPANKNINRSLQYKRTYYTADTQTNGSPHSLKTTNKKVAYSRTPSAKDSAMHSSNNGNMKSMKDCRGRGRGRAKHTRTRRESFSIWNVGENPRVLDSADLTAFPTLENAALMSKNSTPTQENPWSAPTAESKTAMHKKSRSTNTKMPKSLGMIKPNAIPASSAWSRPISIPERHKPKPPVESPKTSFPWNPDDDIRWATENLDPKRRAIFFKTPEKLQPMIDRGPLFEFHKFGLFPAEIRLQIWELCAKNAGPRTVRLEYHEDCIEEDTYEVINTYFSSESSLPAMFHVNREARAVALPYYEQAFSTVHHLGSIPFNFSKDELFLRCPGAGFLSTTIGMIPERDCMRIKKVYIALKDWVFCEGEHTFTMNIAKFRACRRLLLVAGDGLTERKWTQNQEKAIEKLQKVLLPRWNKLNHTPPPTIRFWIIPALKARELRIDSFYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SGN9</accession>
    <name>A0A3D8SGN9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Adenylyl cyclase-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_03778</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The N-terminal domain binds to adenylyl cyclase, thereby enabling adenylyl cyclase to be activated by upstream regulatory signals, such as Ras. The C-terminal domain is required for normal cellular morphology and growth control.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SGN9"/>
    <dbReference type="OrthoDB" id="77251at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008179">
        <property type="term" value="F:adenylate cyclase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019933">
        <property type="term" value="P:cAMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.330:FF:000001">
        <property type="entry name" value="Adenylyl cyclase-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.330">
        <property type="entry name" value="Adenylate cyclase-associated CAP, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001837">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013912">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036223">
        <property type="entry name" value="CAP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053950">
        <property type="entry name" value="CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036222">
        <property type="entry name" value="CAP_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652:SF0">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08603">
        <property type="entry name" value="CAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21938">
        <property type="entry name" value="CAP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69340">
        <property type="entry name" value="C-terminal domain of adenylylcyclase associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101278">
        <property type="entry name" value="N-terminal domain of adenylylcyclase associated protein, CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="4">
        <location>
            <begin position="227"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00054756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00072052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW85453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="390" mass="43296" checksum="10A803F0DF670004" modified="2019-01-16" version="1">MIDSTAASTSAATKDQSVPGFISDFDELIDTDVKNFIERSKSLGGLVAEQATIVSAAFAHQRHFLLISSNMKKPDVSTLEELLRPTQGDVQTIIDIREAGRGTSVFNHISAVSVSISVLAWVTCEAKPHLQIKKTLESAQYWGNRVLSEFKNKDARHIEWLQAYYQIFNALANYTQEHFIWGIQWAPTGIDAREIVKTMVPKSTEEVVDVKLVIHVSSQNPSSTKMPNLRRSKKIARIELVKQMWILENFESQTLEIEASISHSILISNCNESTIHIKSKANAVSVDGSSRLSVMIDSLVSSFDVIKSPNFAMQVLGTLPIVLLDQVDGAEIYLGENSLSTEIYSSKCGGINLYLQRGEEEYEEIPIPQQIRTAMGSDGRVESKIVKYSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SH05</accession>
    <name>A0A3D8SH05_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutamate pyruvate transaminase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Glutamic--alanine transaminase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Glutamic--pyruvic transaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_03935</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SH05"/>
    <dbReference type="OrthoDB" id="1732682at2759"/>
    <dbReference type="UniPathway" id="UPA00528">
        <property type="reaction ID" value="UER00586"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042853">
        <property type="term" value="P:L-alanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.1970:FF:000001">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000012">
        <property type="entry name" value="alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000010">
        <property type="entry name" value="Alanine aminotransferase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045088">
        <property type="entry name" value="ALAT1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751">
        <property type="entry name" value="ALANINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11751:SF29">
        <property type="entry name" value="ALANINE TRANSAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="10">
        <location>
            <begin position="101"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00077894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00078532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00080525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW85610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="487" mass="53961" checksum="AAEFF9FEC36EADC2" modified="2019-01-16" version="1">MSSTTALRSLNINNINPHIKEAKYAVRGELAVRSQTYRDQLSKGEQANLPFDKVIAANIGNPQQLDQKPISFFRQVLSLLENPPLLEKEQILEEGLGYKKDVIERAKWLLQQVGSVGAYSDSTGAKAIRESVAKFIERRDGFPAVANDIYLSAGASSGVNTLLHIICAGPQTGILVPIPQYPLYTASLSVLNATCVPYLLDESKNWGTDLEAIKTSYKKAVSEGTDVRAIVIINPGNPTGASLSEEDVKAVIDFAAQEKLVVMADEVYQTNVFKGKFHSFKGVLRKMQKEDPEKYKNVELASLHSVSKGMVGECGHRGGYFELCGFDPEVQEQIYKFVSISLCAPVIGQCLVELMVNPPKEGEPSYELYKQEYEGIFTGLQKRAMALYEAFKEMEGVECEEPQGSMYLFPTITLSDKAIEAAKKENKSPDEFYASRLLDATGVCVVPGSGFGQKENTLHFRTTFLAPGTEWVGRITKFHQEFMDEFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHQ0</accession>
    <name>A0A3D8SHQ0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04148</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHQ0"/>
    <dbReference type="OrthoDB" id="3543556at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW85823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="255" mass="28605" checksum="45D92FBD538552B5" modified="2019-01-16" version="1">MSYPTPPLSSGGRQSPKVSSLPPYASQITTYRAPATVILESTNSIPRPGPYFPPYEAETPRHAHQYDEYYTDSYVPRPKSQSFPQKGHPSSSKSRGRRSPSPILYKIPSPYNASRPRPRPGFVKRVASRFREWVGELVRYARRHPFKAGLLSLLPIVALGGLMKGLVKAGEGLIGWIEDSKRRRVEREGKEDDKLDASSIFGQFSKFAGSKSGPLDGVLKVIQLLINHWCKLTPSPLPRTASILMELYFLEPWKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHX0</accession>
    <name>A0A3D8SHX0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04262</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHX0"/>
    <dbReference type="OrthoDB" id="3798541at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017789094" evidence="1">
        <location>
            <begin position="19"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW85937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="254" mass="25527" checksum="5C5A7C2865991227" modified="2019-01-16" version="1">MQFSTALICSSLAYTALAAPAPVPASAPEVVTAPVTEVATRQTPGLLENLSPDVAALLIALGLGGLSPSIAATLTTVSQGVKRQTPGLLENLSPDVAALLIELGLGGLSPSIAATLTTVSQGVKRQTPGLLENLSPDVAALLLELGLGNLSPSVYATLITLSQGVKRRSVKRQTPGLLENLSPDVAALLIELGLGGLSPSIAATLTTVSQGVKRQTPGLLENLSPDVAALLLELGLGGLSPSIATTLTTLSKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SIC4</accession>
    <name>A0A3D8SIC4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_03853</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SIC4"/>
    <dbReference type="OrthoDB" id="7042322at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050478">
        <property type="entry name" value="Ethylene_sulfur-biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795:SF39">
        <property type="entry name" value="AMINOTRANSFERASE CLASS I_CLASSII DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43795">
        <property type="entry name" value="BIFUNCTIONAL ASPARTATE AMINOTRANSFERASE AND GLUTAMATE/ASPARTATE-PREPHENATE AMINOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00753">
        <property type="entry name" value="ACCSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="3">
        <location>
            <begin position="72"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW85528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="427" mass="47322" checksum="0A6AD57A5CEB9DD4" modified="2019-01-16" version="1">MLSTRGQTYADSGLMSGYLKDKKAIYNRETNPNGAISFANAENFLMQEELLQYINAHRSIDVTHITYNEGPVGTQRLRTAMASHINDYFSPYEPVQSEHVTFTAGVTGLNEMIALSLTDEGQGILLGRPIYGPFHGDLVTKSKCEIVYSSFSSTDQFSPACVEAYESAYLKALNEGVNIKAVLICNPHNPLGRCYSVETLKGLLLFCSKYGLHLISDEIYALSTFEVEGATRTPFTSILSIDLTGLIRKDFVHVLYGMSKDFGAAGLRLGCLITQNEPLTAAIQAIGRFNWPSELSVSMATNILEDKAFVADYTRKARLALGRNYAIATGLLDQAGIKYAEHGNAGFFIWMDLSPYLGNYKNDAEGWEAETKLKELLENNGITMSAGLAYKAERPGWFRIIFAIEQDALEESIRRIVRLVNAEPFKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SIK4</accession>
    <name>A0A3D8SIK4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04336</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW86011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SIK4"/>
    <dbReference type="OrthoDB" id="3556612at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="70"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW86011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="686" mass="78308" checksum="C36288BF5E0817ED" modified="2019-01-16" version="1">MSLLFPYDHLEDGQYRLFKLDIDGQPGSPLSGQLITLYHPRSYAPSWKRLAKNYWNWNDMRYLERSGSGYDALSYVWGSPDRQQSLVLRMSERVWQGKTLKTMDPGRIQGTISITANLHELLIELRHRRYDDFVWIDAICINQRDAAEKSMQIPLMRNIYEETKRVLVWLGPADEVTQGALKILPNLTKIFEGIDHRTYILDPSNLETFTAKGLPPPDHAIWRAIGHLMAHPWFMRLWTLQEVALPEKVHVLCGKETLEWDTLAQFARATRVHPNRGWSIRRQSAAGNTTTGWDSCAMIDICRELRAMNAWGMPLDSLLGIIRRRQVSVPTDMVFGIMGLMAANAVDQMGPVDVTWSLPRVYVRFAQYYIHQEPQECILNHVASTHRDPGLPTWCPDFSQAEESAALGSAWYYDFWIGPEEATHRFRAGWRREGPGQLPLRKHYMLHIMSNTLHRRTLTQGIYDAGDPRLMSVVPDSHRLRVRGMALDTVVAVVDGAPGSESPFTFAALSQTAAWENRCWRLAQRVLGATDDALPAPYYRTMVANQVPGLGLATFWDEHDVVPFADAYRGWRNYLEAVVAAGVDLSAPTHMEPEAMHIAVQMIRWTKHRRFFATRGGRIGLGPSSTREGDELCVLWYCPTPYLLRSNPGTSEKEFVGETYVHGLMYGQALDMLEKGELTEQEWIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SLY5</accession>
    <name>A0A3D8SLY5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNB-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_02980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.690:FF:000001">
        <property type="entry name" value="Cell wall biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000002">
        <property type="entry name" value="Cell wall biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000100">
        <property type="entry name" value="Cell wall biogenesis protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041093">
        <property type="entry name" value="Dis3l2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF9">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17877">
        <property type="entry name" value="Dis3l2_C_term"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="3">
        <location>
            <begin position="766"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="513"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="622"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1244"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1315"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="172"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="233"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="263"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="282"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="528"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="546"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="559"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="629"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1252"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1272"/>
            <end position="1286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW87286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1414" mass="156050" checksum="E041A75AB05B7381" modified="2019-01-16" version="1">MEQQQQQPQPPPPQGGVAGPTGRRLHIAHRRSPSELTPLMSMFSSPGMEQLAIQQQIELLQQQQQQIQATHQQYVNMGMIPPTQHLAPAGAYNPLQPQMQNLQAGNAFQFPGQLPQQQMNAPMGAPTQPLSHRRNQSALPNMGMGPPPAPSSGASGSNFGDFGGQQRENNGQRGGRGGGPPGGGHQRRHSLALPEAKKAAEIAQQKRTTSGFQFPIPGAAEQTDDKSAPSQPTNNTNNTSNTGTRGGRVGAHGRSQSMAVGPSGRGGSSMRGGGNFQFPAMPSTNESSTTQNNDFQRRNSAQGGHTRNSSRNFEGNWRNQPQNQGGQPEQNQMGNFQGGQQGGFQPGHRTRGSMNQSINSLGNFQFGSQQLVQLPQGQMALLQQPMYPGQQLNPLQMSQLQALQAAQMNGHVGLQGSQHAPQLSAQQQQQQRKTLFTPYLPQATLPALLGDGQLVSGILRVNKKNRSDAYVSTQDGLLDADIFICGSKDRNRALEGDLVAVELLDVDEVWGQKREKEEKKKRKDITDTRSSGNNSINGERSHRDNSTNGDESNNEGGIRRRGSLRQRPTQKKNDDVEVEGQSLLLVEEEEVNDEQKPLYAGHVVAVIERVAGQMFSGTLGLLRPSSQATKEKQEAERAARDGGNGRHQEQRQQDKPKIVWFKPTDKRVPLVAIPTEQAPRDFVEKHQEYGDRIFVSCIKRWPITSLHPFGTLVEQLGKMGELKVETDALLRDNNFASDEFSDAVTRSVGLDDWSLAKEDQEGIAARRDFREEKTFTIDPNGANELDDAFHVKSLPDGKIEIGIHIADVAHFIKANSLVDREAKKRGTAVYLMNRELSPLILLVLPSFCGVRQDDLIANYSFPDLGACNMLPPKIASEICSLTPGQERLTVSVVFKVNAQTGAVSDDDTWIGKSIIKSSGKLTYKEVDAVLEGHTDTKLDGAEVKDIQILYAVSQKFRESRLGSDGETIAPLRLIYQLDDENVPVEHNIFDSTTSHELIEELLHKANAFVAQKIAKGLPEKALLRRHGAPNPRRLQTFAERMNKIGYEMDTSSSGTLQNSLFKVDDSDLRKGMETLLVKTMQRAKYYIAGKTPQHLYPHYALNLPLYTHFTNPFRRYADLVVHRQLEAVLSEGKIEYNEDIESLVKTTESCNTKKDSAQNAQEQSVHIESCRMMDRKREEAGGELISEGIVICVYDSAFDVLIPEFGFEKRVHCDQLPLKKAEFRKNDRILELYWEKGVTSSAYVPEDERPKAGASQRATNAAAAARQAAVAERAKKEHEEAQRKQMETGTMSTDDVDALFDDEDDASDVADSLAGVSLAERPTQSVPPSPTRGSLSAAGTLHRTRSDSKVPAPEPVEAKLSLKEKYLKLFTLREENGEYIQDVKEMTRVPVILKTDLTKSPPCLTIRSLNPYAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SM64</accession>
    <name>A0A3D8SM64_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acyl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_03094</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SM64"/>
    <dbReference type="OrthoDB" id="9988775at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046359">
        <property type="term" value="P:butyrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00567">
        <property type="entry name" value="ACAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000002">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF34">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="39"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="160"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="273"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW87400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="41181" checksum="EAFF36021CDB0DC0" modified="2019-01-16" version="1">MSPNPSHGTISFSLPPDLLQYLSSLDAFISSQIDPLQHRDDNNRFFDHRREHARTDWDHGGLPRSDWEDLLRACRKLADDAGFYRFCLPEEYGGRNGGNLWMAAIRMHLARKGLGLANDLQNEHSVVGNFPDVLMVREFGSAEQKEEFIHGRLEGRRSFAFGLTEPNHGSDATHMFTHAEKATKDGIAGWTINGGKMWITGMHVATHCLVFARTHGKAGDAHGITAFFVPRDTPGFHIESFEWTFNMPTDHATLTFQDAFVPDSAVLGTPGLGLAIAQTFVHENRIRQAASSLGAAEYCIEESIKYARTRKPFGKELAMNQGIQFPVVELATQVEMLKLLILRTAAQMDGLTQKEIERDLGDKVSMCNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMI6</accession>
    <name>A0A3D8SMI6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_03214</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SMI6"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017623708" description="Extracellular membrane protein CFEM domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW87520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="25757" checksum="06E75C8CF6568A03" modified="2019-01-16" version="1">MRFSTFVFYAALCVRVLATFQLDLSAFTPCSQNRITIYYDQLSCSQAGTQADAIGCICADATLLRYTAACVGTNCTSQVNETAGTLANVCIENKTPMLISESQFEEYAGEGFTSGKTVTSSTLALAVSSSTTSATTGSTFGVAATSSAIAPAVSSSPTSATNSNNQQGDGNVNCGGSDCGNNISNNTTGSNNNTTTASNSGSGLNVAQIIGIVTGVVGGISAPIGIWLAWRALRKKSNSNGSGDSAPLTRSDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SNF4</accession>
    <name>A0A3D8SNF4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_03510</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SNF4"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000016">
        <property type="entry name" value="Membrane bound cation transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000011">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF18">
        <property type="entry name" value="CA(2+)_H(+) EXCHANGER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="148"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="608"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="639"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="673"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="706"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="734"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="152"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="10">
        <location>
            <begin position="608"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="333"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="423"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="71"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="361"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="390"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="455"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="483"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW87816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="784" mass="84059" checksum="9AD4BA94588A1158" modified="2019-01-16" version="1">MKKTSPDSDNSLDRIRSWARTKAHGPSPLSVDARRNNSIPINQNNVNLHNGTTVLPPFPASDANGLARPSSKPTHNNVADNTSSEHPPPAPPPQADGPGTVVSEDEPEEKKNVFVRFWNTFWAILASSYINVLLVFVPVGIAAKAAGLSSGIVFGMNAIAIIPLAGLLSHATESVAKRMGDTIGALMNVTFGNAVELIIFIALAKDEIRIVQASLLGSILANLLLILGMCFLVGGLRFREQIYNSTVTQMSACLLSLAVMSLLLPTAFHASFSTAAADKASNAVLKVSRGTSVILLLVYGMYLLFQLKSHAYMYESTPQHIIDEELVPGPVAAWMDSSSSDDSSSSSSDSDGSSGSNTTAKRFKRVMRGGRKRRKSSAGSKETAEHIPTRTPSIGTSSITPVHSDHLNEEPQMGHRLGAIDFAEDADNEKSKRKNSISSHKERSMNKRMMKKERKRQEKRERKLAKESAITEGVVYNNPPTEKSPEVNDNDPRRVDFAVMGDLEAQTQPGIEPLPKRFLFGGIRPQIPKTFSQNVFTTPAPTGNPPPVGPVPHVRYGIRRTNSLPDRLNQTASGLTRTTTPAQAAVIHTATPMQVKAEEEANISRTTAVVLLLASTGLVALCAEFMVDSISEVVSGNSALSEAFVGLIILPIVGNAAEHVTAVTVASKNKMDLAIGVAVGSSIQIALFVTPFVVLLGWAMGKQMSLYFTLFETVSLFVSAFIVNFLVLDGRSNYLEGALLCAAYVIIAVAAFFYPSIDDSSNLGGNANTAKMIRDIVVVGLGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SNS7</accession>
    <name>A0A3D8SNS7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03538</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SNS7"/>
    <dbReference type="OrthoDB" id="10398230at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017725773" description="Hydrophobin" evidence="1">
        <location>
            <begin position="21"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW87844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="78" mass="7793" checksum="3E03F7DE09B0716D" modified="2019-01-16" version="1">MVAVKTLAVSLLGFAILASALPLDTIDAASETCSGNTIVCIGGLKARTPEPIPEPIPAPEAEPCVGHTVVCLGGPKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXK9</accession>
    <name>A0A3D8SXK9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_02232</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SXK9"/>
    <dbReference type="OrthoDB" id="5329176at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF129">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="45"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="364"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW91067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="393" mass="43810" checksum="CAB890EF4FC7D914" modified="2019-01-16" version="1">MQQPPMSQILAWPVPNYIDPTETRGHGNVVLNIVLYSVLVFFMSLRVFTRVKLMRVFGADDIFILCAMIPTTAFFIISLVAHTRFLWIRHVYDIPVENVTTGLKMVLATEVMFAAACTLVKLSMLMLVRRMLSNASLFWRRITLLAIAIVILQGSVFCMTVLFQCRPPQDYWKITIDPQPNCINQGASLLVAGIVNTLTDFICVVLPIRTVWHLQLHTRQMLIVVTLFGLGFISCIAGCVRTYYMYMVLKTWDTTWASFPVWVSAAVELYVGIICASIPATKPFFTTYLPAIFGNLTTVSSSHATASARNGRGSHLTPRGTVMDAEMADLEKNKASRNISSLNSSAGDKHDLESIISAQSDYHSTHAHKHGGGIRVSQAVDQLSDSETSRLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYT1</accession>
    <name>A0A3D8SYT1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-rRNA processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_02648</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYT1"/>
    <dbReference type="OrthoDB" id="5596576at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059065">
        <property type="entry name" value="Ig_Tag1-like_4th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059066">
        <property type="entry name" value="Ig_Tag1-like_5th"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046368">
        <property type="entry name" value="Tag1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055011">
        <property type="entry name" value="Tag1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895:SF3">
        <property type="entry name" value="PRE-RRNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26174">
        <property type="entry name" value="LEA-2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26150">
        <property type="entry name" value="LEA-2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26153">
        <property type="entry name" value="LEA-2L_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22786">
        <property type="entry name" value="Tag1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="Tag1 C-terminal" evidence="3">
        <location>
            <begin position="471"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="domain" description="Tag1-like fourth Ig-like" evidence="4">
        <location>
            <begin position="598"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="Tag1-like fifth Ig-like" evidence="5">
        <location>
            <begin position="747"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="727"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="737"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF26150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF26153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW91483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="871" mass="94096" checksum="5BFA4F6FDA8840EB" modified="2019-01-16" version="1">MSDNQSSPLLGSSQRPTSAHSHHSNEPHENQPLLSRTDGTPRYDGEVDANERITSPAATSLRSLQSHGPGSIKSTKGGRRWPTIIAVGTLGLVVVAILIGAFCAPAIVEEYAKESLVIEPTNLSIHSFTTTGVKARVQANFKLDASRVKSGTIRKLGRLGTWVAKEVESKEALVEVYLPEYGNVLIGTAVVPGIVVNIRDGRTTQIDFLTDLAPGDMDGVLRIANDWLEGRLDQIRILGKTNVALKSGLIPLGSQKISESLVFEGNDIPTIPAYNITRLNFREIPVSTAGQRGMAADVSISLINSYPIKLSIPPLGFDILVPNCGPDDNYIRLADATTATINVEPHSEVNIDVGGVVRDLPKNLLKTCPHSHSSPLDLLLEEYIHGNDTTIFVRGSDAPGADTPDWIAKLISSVTVPVPFPGHTFDNVIRNFSLTDTHFSLPDPWAEPDTDESKPQISANIMVLAGIPQEMNFGINVTRVRANADVFYEGDKLGELNLKKWQKAQSKRVNSTGDDAAIEIESHIKNAPLTVTDDDVFTDVLQALLFGGDGKAVMLKIEALVDIEVSTVLGEFVIKDMPAEGIVPVKPISTGEDFSKLKPKVGDLAILDTGKTSLDLEANVNFTNPTEYTAHVPFINIHILHNGSIIGEATARDVDVAAGDNANIIVQATWDPTRFGGEKGRNISRELISQYISGFNTTLTFRTHEGSIPGQPGLGLALSKFEIEIPTPRLSTPNTGHGHDSPDEDGDNNRPHFIDDATFHLFTSTATFTLLSPLQHSSIYIESIDATAFYNHTEPVGRIEYDLPFKVPPGASTTPKLPVDWSLDSVGYDAVRKALGGKLKLDAKGIVGVRLGRWSETIWYIGGGIGASVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYZ1</accession>
    <name>A0A3D8SYZ1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_02153</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW90988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYZ1"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN DAL81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="370"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="179"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="113"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW90988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="778" mass="88102" checksum="B8F9A29DC7A892FD" modified="2019-01-16" version="1">MEPQPDQAAQVSDLNINELSNVPQGRGRRPRSQTERPCDLCRRRKVGCCIETPGTPCQLCRTLQKECTFVTKPERRPRKRAHVELATAPPPTDGFSSNNLRIGAVLNEVPDTSFGNTPNMSLQSTTSEIGFEDDPEPLRNDSAEQFYPELYINFDWMTPLSPWKQRKITCYPFASGLSDQQHTTWPPLQPSSENQSTFDSNRNESVERAPASTQPLLPVGANIASTANSFPKSPANISRDPGQLSSWESSSLPRRPRKEKCTRYVGPSAAIDPYLLAACQDENQHGPFYSLWKDNGSKHIASFWTSDHENTRSLENHSSTSKSSEELLFSIVPSSQLAAYIALFFKYIYPVFPILSKSWYASIIKSPDALFSLPIGLLAAICGTTMQFAIFDIDIDLDPGYEQETIECLWALVHRELQKDTQVPSLTSLQTLLLFIHKMPKLPSLDDSFLLSQYLGQCVSMTHALGLHVEADSWPIPGWELRLRRRLWWAVYMEDRWRSTCTGQPALISGQRSSIRVLSRDDFGYGQHSESEQHGEGKSSKIEKRDYPGDAFQRLCTLTFILEQVLTAFYVVDTHTTNYGLLLQNAKAIRIKMSAWYADIPQSLHLGKELPEVGDPDSNSALHFAYFMVDILFYRALMQPINQSSLSLECSRSFEGAIDAVFPAAGMCTRWFIDFISETRARNCTAFWYSWCRPALVYMPVFAIMMFIHSRTETEAVENWALLDLWRKVSQTQSRDLKMLQYATSVLRQFDKHGLINFCVIGSSAYKLLESRTPQVAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZ83</accession>
    <name>A0A3D8SZ83_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="2 12">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BP5796_02787</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 12">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="2 12"/>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZ83"/>
    <dbReference type="OrthoDB" id="3000483at2759"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
        <property type="term" value="C:ribonucleoside-diphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01679">
        <property type="entry name" value="RNR_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.70.20:FF:000001">
        <property type="entry name" value="Ribonucleoside-diphosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573:SF6">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51998">
        <property type="entry name" value="PFL-like glycyl radical enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="R1 subunit of ribonucleotide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 12" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="14">
        <location>
            <begin position="1"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="769"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="837"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="782"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="798"/>
            <end position="810"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDW91622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="909" mass="101313" checksum="E2DC7A60812A36A5" modified="2019-01-16" version="1">MFVWKRDGRKERVQFDKITARVSRLCYGLDADHVDAAAITQKVISGVYQGVTTIELDNLAAETAAYMTVTHPDYAILAARIAVSNLHKQTKKQFSSVISDLYHYVNPRNGKASPMIAKATYECIMKHEAELNSAIVYDRDFNYQYFGFKTLERSYLLRLDGKIAERPQHMIMRVAVGVHGDDIEKAIETYNLMSSKYFTHASPTLFSAGTPQAQLSSCFLVDMKEDSIDGIYDTLKTCAMISKNAGGIGLNIHRIRATGAYIAGTNGNSNGIVPMLRVFNNTARYVDQGGNKRPGAFAIYLEPWHADVFEFLDLRKNHGKEEVRARDLFYALWIPDLFMKRVEKNGDWTLMCPNECPGLADVYGDEFEALYESYEKEGKGRKTIKAQKLWYSILEAQTETGNPFMLYKDACNRKSNQKNLGTIRSSNLCTEIVEYSAPDEVAVCNLASLALPTYVDMNEGVYDFAKLHEVTQVVVRNLNKIIDINYYPVPEARKSNFRHRPIAVGVQGLADAFLALRLPFDSPEAKALNSQIFETIYHGALTASVELAKIHGPYESYEGSPASKGELQYDMWGVTPTDLWDWDALKAQIRQHGIRNSLLVAPMPTASTSQILGFNECFEPYTSNIYSRRVLAGEFQVVNPWLLKDLVDMGLWSDNMKNRIIADGGSIQNIPNIPADIKALYKTVWEISQRTIVQMAADRGAFIDQSQSMNIHMKAPTMGKITSMHFAGWKLGLKTGMYYLRTMAATAPIQFTVDQEALLVADTNVARERTVKKRGPSTGYVSSSSPAPGSAPRPMYLKQNSNNTANSNGVPTPTNTPPPTAEPKKFVAAPVAAHTFKADVEEGDSPKALATEPTSLPPKEEELPEPAMQGKKQEEDKDDDNAEREHDIYAEAALQCSIDNKEECLMCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZC6</accession>
    <name>A0A3D8SZC6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GED domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_02283</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZC6"/>
    <dbReference type="OrthoDB" id="415706at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF21">
        <property type="entry name" value="DYNAMIN RELATED PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GED" evidence="5">
        <location>
            <begin position="691"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="449"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="752"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW91118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="791" mass="88891" checksum="3D0F45E3356F555B" modified="2019-01-16" version="1">MSLYSREYDHGSDGVSVAENEDFEDQEGEPYFAQNLNSSNLLLTDDPFSNAMNRELFEAIDKLRRVGANQDIALPQLVIVGKQSSGKSSLLQSLTGIPFPTGGKLCTRFATRIVSRRDPSLEDITVTASLETGDVDPFKYPWDSSVPDSFPPRVLTTFTNESFQDAMNEASKAMGIKEDGPNQQHFSSKVFKIEIAGPQQFQFGILDIPGTFSVPTSQVSVAEMEGVKKMVASYMKQKENIIVCVVEADGDLAHQDIFTLAAEHVSERNLISVFTKCDRAQIPEIIVQSVNNKESVHDMQLYHGWHVVRNLAPQDPEGTDRELEEHKLFSQSPWSEIPANRRGATMLKRYLSDLLCKRIAEAFPGMLATIEKLKNTERSRLDRLGDPRPSVNDQRAYLMSIVHKYQVVASQALRSPADLELDDIKLRGKVQRANEDFAKQLRKNGKTYPFLEIDLPPPTPVSTTFKQSTKREPPMIKVRAVSESESEEEGNNPKHYGSARNGMFGVVSSEIIPTKKKPRNKPSPQATSPAAKSLYGEIRAQMETNRGEELPGFPNAAVVKPLMRLQSKKWYSIADAYFESVASLAENTSRNVLKQICHKYAPGVTRDKLEQVILDKYHTSKTNNPQYMEKIQMAQMSRFRVALSNYRSKCLPQEFPNIGPSTALEHMILVNDATITKLHEEIHSSQQKNMEDMIHDILKAYYEVAQEDFILHVTEHVVEPFLADEEGPIFGLSTAYIGSLSDEQIEDLGKEEDSVVDDRKRAKEKIARLEAAEKIAKETVRKTKTTEVSEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZQ6</accession>
    <name>A0A3D8SZQ6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_01201</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2546325at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="321"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW91807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="2157" mass="246702" checksum="DE0C939FADFD9C6C" modified="2019-01-16" version="1">MVDTQLISEAASTAFENTGNLVKSQAYPTNNGFRTPSFTSYHPTSHSRKSSKADTRFGSMSSAVEGRTTRAHSYDLSASQQWTVFQEICSHTRDCLLREIEDVDSYYIDSLSLENFINYIELERLAHMPARGSRYDKILRWAEFFALQISGYEVSIRSSIPETKAAAKLILASCRVLIELGPENAQAIEPAFQQLYKIGLSLSFLLRHHELMSGNMHIRTDIGQAFAAVLELVRDICLNYSMRIGAISSSEFTTDFSSIFGSHIRAFNQHKENIIEGMWELQVTNIADVKEIRRWLAVHDSTAQTILQEQSNGGIYRDEYTCDWFQSHLLGFVRGSKDMLALCGSPGCGKSYLSSWIIERLQRPLNRISYEVLSYTVDPDLPGHTDSLSVARSLALQLLQINVGDAELLEALKHALDISNRSRDLEEIEESLWAALSVGLGNLGDKRLMIVIDGLDEVKLTLKHKSSLNTIALWIADAVSENRQIKTIFVCRDASFDGSMASRCHKFKITPDHTHTDLHHMAKHALKKTRHYADQDTINQENLVESLVYAADGSFLWMHLACELLKRQHTREELLKVAKQLAKPTALKELIKLVVGAVDLVNGHTKKLLSWLLVSLRPLRLEEIQSLSQVDTEKKVIGTRKDYFSEEQLQNWSSLLTIRNGIVRYRHQSIKSYFSGLQKDGKLPKSNAAHQDLMHRVLMYCKFRLPDDYTPMFDSIDVAEAELSLQRDHLIGYAARYWVFHFEATPVFHNYQITNTLDLSSSLWLDFPSSVHFALLEGYCLNLSAPAYEALRLHKLTLQIRQSMLTENHESVLQTLIFCGKLLRQVEARDEALECFYRASRVSRSVLEEYSNVTNMCIVSFLELCSTITSTTRTELVTRKEEVLKYIIVSSKHQYGKASDVATEYSTILAELYVSIHEELHAESIWKEVEETMPIRRGRGSIDQGSFPGRLDVTLKKGRPDAIKESDFDIFSTTLETGVWDITRIKTSLEMALRLEHENDMFGAEKLYILLWSQVLECCHSVTRQILDIDIHISMIDVAIEYVRFLHRCKRFEDEASILICLWTEYEECDFDAEDIFLRLKLVGEIMRTAELFSVAVTVFKKCSAWFRSRRMHAHAESCDVLISETLLQVTTTTSSKATTDKRTITKTVTRTTVESETFMKDVFHSITSKANITRESLSICSSLVSHYMELEEWSEAIEVSTKTLEITWKTAIHGGTTLALPREFGHEAVEIAICLALCHHRSNHFFEAEEVYLRVYRACFNSCSFHDERLTRSWTALIKFYEEHRHWNKLIEVYEELLSASRKHFGTNHARTIKLLYTLGHLCTEHGYFRGHEYYEEIILVLNGDDWCHKDSIKAMMAISKFYYENGHWEHLRVVCESLWATWIQHHHDHQFDADFVEALYARYVYVLQYHCDITYDVIRSITIQFQETSLKIYGAKAAITVRAMIELANVCMRSEKNMHEAITYYEKVIEITKTMSSTESSTLKISTMTITTIEKRLTEAYVHVCSYGSISATIIDRAVIIISQRLEHLTASLGWSHAETLRVLKELVMLYLKITSAENITKIKRLLVSAVVSVLSLKTTATALYNAAKSLGDLYLACGLIDEGQTLLDDLRAEAICKTWKPKRNGDFKLEHRIGKSSFVFLVTFQQVLQGTSTSSYSKIMSDLLIEAFLYEEYSLSSTSKKSAELVLIDGAKLYMHLQKSHRVEQAAVIYHELLYTFTTKWTLCLKGSKETTSVLFTTILEELGKQSGLVRIGYAASVSSNRKVRDLLDDGKAKEAYEFAQCAFEFIHKEGAYRYFHNVGWGFKLSELMAGRGRKEFEKPVKAELRNQMLELSRRIMLDVYLVCKEAKVNFMQLDKSELSNLTGLLGEQKNYAYLEHLLESLWSSKEVQKSWSKQTIVDVGLRLIQARFLMSKTSKAYLPDALKLGETIYYNLRRVGGGLSPKALEVSDVLVQMYTETHNHREAMRVVEDILRMIVEGDDGEEDTSDVPTAEAVSHRLKMLKYSYQRHGRWDKTNSAYIDLVHKLHLMPQYKHDATIQTYADIQQWKPKTDDKDHLAFMVPDNWEFTVDTDEQFTISTDSLPTSPRGCAYGRGSLNLPKTSAGSWLHNGTSATRRVTHDWGMGSLYGDLFVQQSDDEDISPTQNNHGDKWQIVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0U5</accession>
    <name>A0A3D8T0U5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_02793</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0U5"/>
    <dbReference type="OrthoDB" id="2624308at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="671"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="713"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW91628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="914" mass="103672" checksum="336CFD9B92B51FD9" modified="2019-01-16" version="1">MSDYSVPRKALPGRGDTTYAASHGTESGNTDPSLKPSSARPETRPTGSHDLEAGPEMVKGHLQPPETEQQQAGRWRRMLSRSKGPTRLLKEYGGGVGIQIPSMVRYKRPDMSKSTALSRLSTHPQDDKKLRYRNKMGLLTYKHHDVPVYLSTTTYEPRRLLIQCTKQVWDAPSSGDWRQVKMKGSVPTVLKMAEWALRPADKRKIVKSNGEVHERRPALGLVVAFGRMILVGPFLQGLMALPGMTAPWEQDVETNDKYDDYPGYHWDWPEFAVNKFDMKPTRQDMEAKVDEKMAKFSAKPRQVRPTALVVYDPSTKEWTIEHEPSSDIPFVVVSFTRAHFHVDESATFKVTAEDAKMWKTELEKMCRYVARDHFEAEMPTGRKPSTRKYGYWLDYQCGSEPGASEDDMNHHINTICDVVRSAKKVIIALPQAPDRTTGQHLIWGQSLWTLSEILLASGDIKVCWPESDYPLTDGMVCHVESWSKMEMTRTFWEEEKQEEDEQPTRILAEHFSGLLSLGRIELFITALAAFEDRFSRGTYGPQELSRALMALFHHRIDNEKTESLFHCLARVNMANDNDDLIERMICWSPSAGTSKLSPLLHDIFSLYRLSFPDRFGSRLWNIRPMCEVVGLAKEENTVMIDGCRSISIRWKNFPRLQYKRSYGFKKLFAELLVRSGSAWIVAGFTIAFYYLPLYVSDGAPDFNSTNPPGTDDAGLRAALTILIVGFALVVGFILSLLGPSCVRRLYGGSVVESTARLVAFEGTMPAKEVEELIFGNFRDRLAWQPSATPLSRAESDIRIGSSPSWLVDGQEPDYQELERVRKQLDIPPNHKIFTLVDTGRLTISIFSAQYPPSVALLCGRDGGMLRAVLCSWDFKSDCLYKETVMRMPSEVWESATPKSWLKLRLTSRSPFLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T123</accession>
    <name>A0A3D8T123_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_01659</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T123"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF198">
        <property type="entry name" value="AZOLE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="319"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="443"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="53"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW92265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="560" mass="60210" checksum="D5D6D25826AEF55D" modified="2019-01-16" version="1">MDDEKSSGGLGRTSLTRDQAIPKGPEGIADNKSEIQHSGPTENYITGLKLFVVITALCLAVFLVALDQTIIATAIPKITDHFDSISDIGWYGSAYFLTSTSLQPTFGRIYKVFNVKTVFLIAIGIFELGSLICAVAPSSTALIVGRAVAGMGVGGIFSGALVIIAISLPLHKRPMVFGAFGGMWGLASIAGPLLGGVFTDKVSWRWCFYINLPIGAFSVAVVVVMLHIPRDPNDSNKSYLDRFKELDLIGASILIPGIICLLLAVQWGGNTYPWNNSRIIGLFVGAGLLIILFIYSQIRLGDKATLPPRILKQRTVGAVNAYVFFFGAGVFVLMYYLPLYLQAVKGSSPTRSGIQILPLMLSSVLTSILAGAYITFVGYYTPLIIFASAIMTVGAGLITTFDIDTPFGKWFGYQIITGLGAGVSFNVPLIAVQTVLPMEDIPIGTVCVMFFQSLGAALFIAVAQAVFQNGFIDGLRMYAPELDPTVLVNTGATSIRTLLKNMGREDLLRPAIMAYVHGLKNCYRVVVAVMGVAFLMTCLFEWRSVRKEGKKGGEMPAIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1F4</accession>
    <name>A0A3D8T1F4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Proline-specific permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_01723</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1F4"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF35">
        <property type="entry name" value="ACID TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="6">
        <location>
            <begin position="1"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW92329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="511" mass="57164" checksum="0260FBFB117C8BC2" modified="2019-01-16" version="1">MTALMPVNAPVMEFPRRFLDRGVGFAVGWMYWFAYAVIAADELVAVTSTVKFRYDDGTTFLSWKVGENVDPAVWMSLFLVIVVCVNMFPVKYFGELEYIFGCIKLTFITMLIVMMLILDIMTPRSNAYYKTPIGTKYWDSPYSFFTEVYHVKNSNGDLQRNINGAIGTFLGVWTTCVKGLFAYVGMDIVAATAAESKALANAESMKMAARKISLRIIALYIFAVLTASFVVPSDHPFINGGGQSVGASSIFIIAVVEAGLPSAAHFFNAVFVFSSFTCAINSLYVASRVLHTLAIRDQTGPEFITRRLRQCRSGVPIRAVLVTGFVMLIGYMGRTGTLGERLDELASNCTVSFLIVYAIICATYLNFFKTLNDFKLYGNTSESQAASYDRNHPRYPYKSHGQWVKAAYGMTACIILLIFNGVGSFLNDPFNANKFVASYIGIPVFFLLILGYKIRKHGFNISHWGAERSDDLRNTVQVASVKRKGRLEFLDEGFTMDNAREFIAWLWVWVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1S5</accession>
    <name>A0A3D8T1S5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-like ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_01916</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1S5"/>
    <dbReference type="OrthoDB" id="2963168at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF79">
        <property type="entry name" value="HSP70 FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G15200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW92522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="735" mass="80036" checksum="A41E75FFAEBFEE66" modified="2019-01-16" version="1">MSSSSSRFKSLGFGSKRKSSGNTPTLQSPNASAPQIPPLAGRPASVASSSSSSLPMNHQPGGGRPPSYSNNYAPAPAAAGRTTSPLAANGPRTPPSQMMGGPPPIITGSGYPPGHPQASQQIGGPPVAGGPPQYNPPQYGAPGQGGGAAAQYANRNNAVEVEGAGRSKAQLIVGIDFGTTFSGVAFAFATNTEAKEDIITEWPGAGSYTKQKIPTVLYYDQYQKVVGWGPDIADALAPTGYPKPGVQKVEWFKLQLMLSGNTYIDPINLPPLPPGKSEIDVAADYLFKLRQAMRNQLQKTLGEVFNREERNIRYYLTVPAIWNDAGKAATRAAAIQAGFLRDENDNRLTLITEPEAAALFCSKTGLLNLKVHDAVLIVDCGGGTVDLIAYEVEEESPFTVAECTAGSGDSCGSTALNRNFSNILRTKIRKMKLPDGSKTAGRVYAKCIMDFENRIKADFRNNNQKWAVDVGIEAEFPEAGIEEGYMTFTNEEILQCFEPVVNRILELVRNQIIAIQAQNRTLQNVLVVGGFGASEYLFQQIKLHVPPQFQAKVVRPMDSVAAIVKGAVTAGITERVVTSRVARRHYLMATLQPFKEGHHPEAYRVPSLDGKDRCKFTRQIFVQKGQRVKIGEPVKVSFFRQVAPGATLMYEDILYACDDDVCPEYTKDPRVKEVVTLTSDLSRKNLEKDFERMDTPQGTFYRVYFDIYLTLDGSEFNAELVCQGEVMGRCTSRFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T214</accession>
    <name>A0A3D8T214_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mediator of RNA polymerase II transcription subunit 31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_01964</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Mediator complex subunit 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T214"/>
    <dbReference type="OrthoDB" id="10257739at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1340:FF:000002">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1340">
        <property type="entry name" value="Mediator of RNA polymerase II, submodule Med31 (Soh1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038089">
        <property type="entry name" value="Med31_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008831">
        <property type="entry name" value="Mediator_Med31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13186">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05669">
        <property type="entry name" value="Med31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0010">Activator</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW92570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="128" mass="14430" checksum="59CF5FAAFCA1D7A3" modified="2019-01-16" version="1">MASASPPDLNMADTQAPPPLPTEGEPKYGGFTRFEIELEFVQSLASPYYLNHLAMQKYLESPPFIAYLKYLQYFASPPYTKFLNFPGPTLKNLELLQQERFRKDILSLQVVQAMVEEGGKASLHNVAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T286</accession>
    <name>A0A3D8T286_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7029 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T286"/>
    <dbReference type="OrthoDB" id="160645at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054293">
        <property type="entry name" value="DUF7029"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22974">
        <property type="entry name" value="DUF7029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7029" evidence="1">
        <location>
            <begin position="107"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF22974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW92666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="525" mass="55366" checksum="70891CF410D4B8B9" modified="2019-01-16" version="1">MAVALSSLTLAAPASAPLTPTILSPISGSDSFSIPEDRIAARQAAPLMTLSPITSTGNVLIPADAISKRATVGASKRQVAGLIPSSNITLDYQYASTSSVLLAQINATMKHPSVLLEDIKSVTKVDCDVTSVNITFGDQAEFDASSASWPTSSFILFTNHLGDCDAENERGLYIVETMTFDPTTFSVMASTTKSTFQDVTENMEIVFTKPFATSAKRAVTQTFLGDFPGTISLSHSPSKTKFSVSVQSPSLSGSFAMSGHGKFNLIKKKAIKFHIDLEMSIEAAANVRVAAGHSYDNDVYTYSPASLSISAFTIPGILDVGPMLELGVGVEVAVSGEVDVSTNLTASLPTSHVRLDFLDSAKSVASGWEPVYRHATNITVPIDGQVNPFVSVTAAIGIKFLSGILDLSSGVTTRAELINDFSLNGQFNIDSSGNVTLPASSVTPPASNLTLPASNVTSSTLNGTLPASNATNPMATNATCINGISFSNAFDVIVTAFVTQFYSLELYRLDVPIYQSKCWTWGTPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T738</accession>
    <name>A0A3D8T738_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Checkpoint protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_00087</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the HUS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T738"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044778">
        <property type="term" value="P:meiotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016580">
        <property type="entry name" value="HUS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007150">
        <property type="entry name" value="HUS1/Mec3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900:SF0">
        <property type="entry name" value="CHECKPOINT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900">
        <property type="entry name" value="MITOTIC AND DNA DAMAGE CHECKPOINT PROTEIN HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04005">
        <property type="entry name" value="Hus1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF011312">
        <property type="entry name" value="Cell_cycle_HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR011312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW94324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="337" mass="36774" checksum="9363CF149D64A422" modified="2019-01-16" version="1">MRFKTSVRNINTFTKLTASLSSLGKVAWVRLDDDNVRFTIIPESGTQVWASLSIDSIFEDYTIQSAIENNTINLELPLPPLHRALKSAFNASSASIRLTKKDGVPVLSLTIITNTISGGNNATGFLSSANDDPFGENFREEHLDAGGRDREAIVTQDIPVRVLTPESVEGIHEPRVREPDAHVLLPSLVQLKAVSDRFTKLAMATGNGTTKSGAAVPKLELRANMHGSLKLSISTDALNIESVWTGLENPELDPGQVDDAVEEHPSSKLRAEGPDAWSTVRIDGRDWGRVLSVGRLGGRVIACFVNEHALILYVYLANYDESGEESVLTYYISSFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T782</accession>
    <name>A0A3D8T782_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="9">1.1.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_00215</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:13521"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the FAD-binding oxidoreductase/transferase type 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.4" evidence="9"/>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T782"/>
    <dbReference type="OrthoDB" id="7786253at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004458">
        <property type="term" value="F:D-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008720">
        <property type="term" value="F:D-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903457">
        <property type="term" value="P:lactate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.465.10:FF:000014">
        <property type="entry name" value="D-lactate dehydrogenase (Cytochrome), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.45.10:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2740:FF:000001">
        <property type="entry name" value="D-lactate dehydrogenase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.45.10">
        <property type="entry name" value="Vanillyl-alcohol Oxidase, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004113">
        <property type="entry name" value="FAD-bd_oxidored_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016164">
        <property type="entry name" value="FAD-linked_Oxase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016171">
        <property type="entry name" value="Vanillyl_alc_oxidase_C-sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11748:SF111">
        <property type="entry name" value="D-LACTATE DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02913">
        <property type="entry name" value="FAD-oxidase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55103">
        <property type="entry name" value="FAD-linked oxidases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="11">
        <location>
            <begin position="95"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW94452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="522" mass="56530" checksum="9DFF25E4FF11060E" modified="2019-01-16" version="1">MPKPETPPSSKSGRGVSALSLLTFACSAAALGVAVSMKLSNKPQYGALNAPKYATTKEMLKAIDEIRSAISEETISTDDDDLKMHGFSEWSQINIDTLPIAVAYPRSTEEVSKIAKICYKYHIPMIGFSGGSSIEGNFAAPYGGISVDFAHMDKIVAFHEDDLDVVVQPAVGWMKLNEDIENSGLFFPVDPSPSAKFGGMVGTNCSGTNAARYGTMKDWVLNLTVVLADGTIIKTRNRPRKSAAGYNLNGIFVGAEGTLGLVTEITLKLAVIPKEFSVAVCTFPTIRDAAATASAVMRAGVPIAALELLDDTQMKVVNKGGNTAPRVWKEVPTLFFKFSGSKASVADNIKEVQAISKKHNAGSFEFAKDEKEQHLLWSARKTALWSMFALKPEGTNFWSTDVAVPYSRVAEIIEISKKDLEGKGIFTSIVGHLGDGNFHEAIFYNKSDPVETAMVTKAVHDMIDRALEMEGTCTGEHSIGLFKKGCLLQEVGPDTLLVMKSLKQSLDPRWIMNPGKIFDIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T792</accession>
    <name>A0A3D8T792_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="3">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_00179</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T792"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000017">
        <property type="entry name" value="E3 ubiquitin-protein ligase UPL7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2160.10:FF:000015">
        <property type="entry name" value="IQ and HECT domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF2">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="8">
        <location>
            <begin position="801"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="651"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="659"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="1142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW94416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1174" mass="131964" checksum="262697A79969404A" modified="2019-01-16" version="1">MFQTFSGSSRRPRQVNLSGQNQNPFAAGSWAPTASGTQKTVENAQQERLRRQRERERLNAAKRLQRTWRGHKVRRELANSRRRLWDESVGSSGGSIASFAAHLQLFVAFFSPRRSDDRDRLESLSSGMANGGIKTFVGLPNVQPQLLRLAKQIVGTLQFSTPHISPVVLELLVSIIDVRPDIFHHISRSYYDILSSATRNLKSSSHARGMIVTALKVPLVRHGELTDSYELCLDAHSAFALYFLTVSDLDSLLGGLKDLASGVDAGLLSTALVREYTSTSAYQISAENRLWLLANFIALHRLQRRDNQESQYLRALSLQLSSSSTEIVGRIDFVDLENPQDEDEKPPLQPLPLTIKEELSSLVNQENISNLLEKFSAESAQSSAAADEDASLLASYALTLLRIFPRRGDEIRMWLYRGSMANTTGSQIPALKFFWQATIATATFSAILGDSKSALSLLRSQMRRSSNNGTLSDIMQDREWRTILLFLELYTFVLRFTDDEEFLSGNKLAFGQSEEPVSRFQQSALPIEDVKQLTIFLKNLAFTTYYNTAELTEDDQQFLDGGLGSYFGTSIGQSSRFGTNTVEGLEKHKPKRPFAGVAGMTFEYVRTIVTGIMRMLYERDSRRRFLPKDHWLMTSRFDMEGFIPAVVMEEERQHQVREEGEEDDGEDDMASSERDDLIGMARPRRALQLESLRKQQQKTARKKILAAVGPRLEILQNMPFVIPFESRVQIFRQFVFLDQTRRRAGNVDPDIWRMAMIQSQPVAGANRPSGREMLGRHHAKIKRNNLFDDAYSQFYQLGDGLKEPIQITFVDQFDTAEAGIDGGGVTKEFLTSITNEAFKTVGDSSLFVANDQNLLYPNPAALDERRELLKQASIGDSTAKGREMITDLLRRYEFLGRIVGKCLYEGILVDIGFAGFFLLKWATSGGSGPESGYRANINDLRDLDESLYQGLLKLKNYPGNVEDFSLDFTITDTVSLPGAPTQTITRELMPNGSNIAVTNENRPLYVSYVARHRLQVQPYHQTQAFLRGLGQIINPSWLSMFNQSELQTLIGGDASEIDVEDLRRNTAYGGVYQIGDDGLEHATVQLFWRVMQQLDDADRRKVLKYVTSTPRAPLLGFSQLNPRFSIRDAGSDEERLPSTSTCVNLLKLPRYSTAATLRSKLLYAVNSGAGFDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7Q7</accession>
    <name>A0A3D8T7Q7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PhoD-like phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_00323</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7Q7"/>
    <dbReference type="OrthoDB" id="9999821at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043904">
        <property type="entry name" value="PhoD_2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689">
        <property type="entry name" value="MEMBRANE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46689:SF3">
        <property type="entry name" value="PHOD-LIKE PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19050">
        <property type="entry name" value="PhoD_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="267"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="494"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase" evidence="2">
        <location>
            <begin position="580"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="703"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="737"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="763"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="777"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW94560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="867" mass="95468" checksum="657BEB0ED0FB9F57" modified="2019-01-16" version="1">MASHLKDDLLYGEDHPDTHASASRWRHQETPSFARHAAPRQADAKHHTSRDLADFFNSTRVSPAPGSSGTGGSRKHTPLVVAGGANTHTQNGQQTLVAGLAEGETSGLEVKCGPLLNYRRMEDETWFGSVLIVTKSGGSAADFVPELIIRTKERSHSGTARLEQAGTATNDTNGANGMDVAHGECNGVDSTTFPSGASHSNGGHANGDSKYDSSRENRGKGTKLYSDLSNTFWRFDLAIPLEQYELQCEYEIPGLRFPKGTTKMDKNEFFIPAITESMRIMFHSCNGFSVGTDEAAWSGPALWNDVQRVHKVTPFHIMLGGGDQIYNDSIRVSGPLRPWSDMANPTKRRHHPFPESLRKDCDQFYVNNYIRWYSTEPFATSNGQIPQLQLWDDHDIIDGFGSYVEDFMKCAVFRGIGGVANKYYLLFQHHLAPPLSTYTTDAPQTMSDAGAAPDPRQLENTFVLNEDTIDPSYIIGAKPGPYVAEHSRSIYARLGARIAFFGLDARTERTRKQVNYPETYELIFSRIRQELKKASQSSSPVQHMIVLLGIPIAYPRLTWLENIFSSPLMGPLKFLNKRFGFGGGFFNHFDGSVDLLDDLDDHYTARTHKKERLYLVQQLQAIASEFSVRVTILGGDVHLAAVGRFYSNPKLDIPIANDHRYMANIISSAIVNKPPPAAVANLLARRNKLHHLDHDTDETLMSFFDRDPGEGSKTSKSNHVTMPSRNFAMITENSTTRASANDTNGFNGTTHTDGPVSNGRPPGSAAGTATSGKSSTKTKDGHSWLHKGEVDAGTSHKAAQPDMHGQDTDGSLDVCIRVEIDQHDPEGHTRAYGMTIPYLKYDGAAEKTLKKHEAVRGTVSEKVAGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T836</accession>
    <name>A0A3D8T836_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_00463</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T836"/>
    <dbReference type="OrthoDB" id="445896at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01786">
        <property type="entry name" value="RA_STE50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09533">
        <property type="entry name" value="SAM_Ste50-like_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000159">
        <property type="entry name" value="RA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051569">
        <property type="entry name" value="SHANK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24135:SF28">
        <property type="entry name" value="LD13733P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24135">
        <property type="entry name" value="SH3 AND MULTIPLE ANKYRIN REPEAT DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00788">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07647">
        <property type="entry name" value="SAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00314">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50200">
        <property type="entry name" value="RA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="64"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Ras-associating" evidence="3">
        <location>
            <begin position="386"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="293"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW94700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="488" mass="53670" checksum="07CFFFD69EE81176" modified="2019-01-16" version="1">MAFESGTAYAESDADDEYERSVVNLASDSEATESESPSSNEHTPTTYGNHSSSDRLPETIITEWDATECSEFVAGIGLRQYADCFLENEIVGEALVALQHDDLKQMGVTSVGHRLTILKSVYDIKIKQDIPIERMDYVPESADAESQYATATLKDIRHLVEQLRLRDERMSVAEMELRRITEEYRRLREDLLPVFRMAKEGQPLPYYPSNNNQQNAYAYDASNTVSPPAPTPSSSQSGSGLSRKFSTKKLYYDPPKNASPTHLQTTQERSLMEQALDPANAAERAVLSSSHLAAMNGGSQPSTSPGYPSPNQPSPTSPPTLGGSTLASRSYRSDLNTPARSNFPQNDNDGYQQSAYSRDSKAPSRRAATPALDSGTSGSGASVEIFKSFRVSMDDPCYKVLPAALKKYSINAPWEQYALYIVYGDQERCLGMEEKPLILFKQLDKEGKKPMFMLRKISPNPDVLPADGPQSAGLDGGRRGYEPPGGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8B3</accession>
    <name>A0A3D8T8B3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_00553</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8B3"/>
    <dbReference type="OrthoDB" id="295274at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14687">
        <property type="entry name" value="bZIP_ATF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051027">
        <property type="entry name" value="bZIP_transcription_factors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19304">
        <property type="entry name" value="CYCLIC-AMP RESPONSE ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="6">
        <location>
            <begin position="180"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="118"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="268"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="274"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="315"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="383"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW94790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="430" mass="48202" checksum="D41EC5395EF19412" modified="2019-01-16" version="1">MTEAGQESFAQNTIDPSFILDPSLHSSSSNNNNNNNHNMDFNSFPDHFQDMTNSELSNLLYPGGFGSTGFTPDPNKVLFDHLFHSQQANNGDVVDLQNNPYFAQAFTSSMSVNMHAIETKKTSQPEDSSRNIDGSTNNSRKRERSIEQDKKPGQEAANPPPVKKRRNRKPKKQPSEEEARLKREKFLERNRIAASKCRTKKKESTNELEDRLREYQAERKRMEYVLTELMCEIDKYKEMLQSHAGCGNRAIDTWLTASAEAIAEEVSNRNKGLSRTNSSSASTANISRPLTRNSMRTRFEAYASSRTNSMESLPQSLQSRSMSQHSSGQTSPLIPARETCPKTSTFVFNDAFSPNTKAAMSPDADDWLQPDEVTLRDSGVSDLDSTPSEQGKATTQELQEPFMLPNQRLVEGSFPMFVDDSTPLSLASIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8I6</accession>
    <name>A0A3D8T8I6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Acyl-CoA desaturase</fullName>
            <ecNumber evidence="14">1.14.19.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BP5796_00619</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:19721"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="EC" id="1.14.19.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="14">Expected to bind 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="14"/>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8I6"/>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009160">
        <property type="entry name" value="Acyl-CoA_deSatase_haem/ster-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000345">
        <property type="entry name" value="OLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4 14" id="KW-0349">Heme</keyword>
    <keyword evidence="10 14" id="KW-0408">Iron</keyword>
    <keyword evidence="3 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="17">
        <location>
            <begin position="366"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR000345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDW94856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="519" mass="57981" checksum="A0CF95425AE0BC4D" modified="2019-01-16" version="1">MARTTTTTQSPPVNSTQPQSVAKQNQISLDASQGRRRRRRRRRSSNPIIHAISALFAILNSINYWNSFWVLAVPAFGFYLATSTPLLWPTAVFSVVYYFVTGLGITAGYHRLWAHRAYTATIPLRIYLAATSAGALQDSIRTWSSDHRAHHRFTDTLKDPYSVRKGLFYSHIGWLIFKQDASLKGRTSIADLDRDPVVMWQHNFYIPLALGMAYAFPALVAGAFWSDPLGGFIYAGILRVMLVQQATFCVNSLAHYLGAATFDDHRSPRDHVLTALLTLGEGYHNFHHEFPNDFRNAVDWWQYDPTKWAIQLWFWCGLVSEVKTFDQNVIERGRMQQEVKTLEGKERLLLGMQGGAVGSGAAAATETLWSWDEFQRATTLELATRPRRHLILVAGILYDVASFLAVHPGGESLLRSAVGKDATALFNGGLETTSHHPHSRPCPASKEAPAWPPLRAESGSAMRVTSVLVLGIEGPWLIVTLGADSAGARRILETFRVGVLRGGCEVEIWKEGYREEQSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8Q3</accession>
    <name>A0A3D8T8Q3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_00735</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8Q3"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF53">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017702002" description="FAD-binding PCMH-type domain-containing protein" evidence="5">
        <location>
            <begin position="21"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="68"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW94972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="521" mass="56465" checksum="84FBE0DD233794C0" modified="2019-01-16" version="1">MQSFKASLAGCLMAAATVCASSVVTVAELSTGATCACTQLASTYGSLLLTSNSTTYTAESIDYWDVRADLLPGCIFKPTTANQVADAVSTLVSCGAQFAVRGGGHMNVSNMINSPNPFRGSALRMRQNPGSNNINGGVLIALNNLTDIKVASDNATVEVGAGLRWIDVYTTIEEYGLYCLGGRLKTIGVSGLELIGGFHYLNNKYGMAMDTVTSYDVVLGNGTQVVANSTSNPDLFWALKGGANNYGIVTKFTLETYPIPYISTTVQIFNESAVPDFLAATANLAENDGPDIGAGAVITIDYNATTKVVTPQLLGVQEGTQSPPSRFANYSAIPALTTSNNVLTPTEWHSQLDTPFQEFRIQFAHKTMKPDANQLVKIYEAWKIAVDEISDVEGLRPTFVTNLLPKSALSVAKNNGVGNTWGFDDNQSYILWQLSTSWASAEDDLRMTNWARTFIDYWHQQNSVLNLSHEFLYLGDAGDFQNPFTGFPVESVQRMRQVREAYDPLGVFHRLNWGGFKLGPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T988</accession>
    <name>A0A3D8T988_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HypA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_00858</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T988"/>
    <dbReference type="OrthoDB" id="10004862at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025337">
        <property type="entry name" value="Questin_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35870:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03330)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14027">
        <property type="entry name" value="Questin_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW95095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="443" mass="50683" checksum="2AFD3D4B551DB2C5" modified="2019-01-16" version="1">MATPYKVQLSVEDTGAVKFQDPTAESAAKVSDLLQKNHDNHHIFFNEEGFHNHIVHGLLSLYGLGAPASVLQRHFDTNASYQRPPVKVEEKIIQDMSDPDNFKKYLGKEEYYRDFLLFFEQEMEKKGWQNVLNEYVFAGDERADGMLVRMYAGFLHPLIHLGFGVEFKQPAIVAEALAQAAVHDAWIGDLLLGAEQANKAQGPTKKTLPELLSDIHMDKKLTEGVQWEDANKIRDGLLQRVSQDMIKHASQWSVSSTTLEEKTAEMINAAVYFTAGAQHPPKQVKFDFFYMHSVNCSVFFTTFNAQTWLSSESKVRLLAWKGYLDLAMYASRGSPELLMEEIVGFVPKVQEAERSSWTGVLRRLFEFDDDGHAIKLGRAVRNGQVVCQKFEDKEWCKIKDWQWEKVENMVVDSVEDTGQNWVRNTGFEKAWEGFEDRPRSTRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9W5</accession>
    <name>A0A3D8T9W5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_01088</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9W5"/>
    <dbReference type="OrthoDB" id="21539at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033962">
        <property type="term" value="P:P-body assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01736">
        <property type="entry name" value="LSm14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025761">
        <property type="entry name" value="FFD_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025609">
        <property type="entry name" value="Lsm14-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025768">
        <property type="entry name" value="TFG_box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586">
        <property type="entry name" value="SCD6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586:SF0">
        <property type="entry name" value="TRAILER HITCH, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09532">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12701">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01271">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51513">
        <property type="entry name" value="FFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51536">
        <property type="entry name" value="TFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="7">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="DFDF" evidence="4">
        <location>
            <begin position="397"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="FFD box profile" evidence="5">
        <location>
            <begin position="452"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="TFG box profile" evidence="6">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="82"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="370"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="FFD box" evidence="1">
        <location>
            <begin position="452"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="TFG box" evidence="2">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="162"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="220"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="232"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="452"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="480"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="507"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW95325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="538" mass="56106" checksum="47C625695E0AABB3" modified="2019-01-16" version="1">MSEFIGARISLVSKADIRYVGTLHEINSEKSTVALENVSSFGTEGRKVSAGLPDEEVPASDSVYDYIVFRGSDVKDLRIEETPVAKETKPPNDPAILGSGSRPTQAQPQGPPQGPQRQNQPTPQAGPANGPPQQHLPPGVPQFPQHPPPFYPPPQGWGRGGPPGPGFPGMPYGAPPGWFPPGQGFPPGPPFMPYGYPPPGQFPPGQGQPPKPAPIGPGANKQQNQAPTPQSSDKDVEAKSLADPDAQNAQKAPTAPMESKPSAGDAPPAANQSSAPQSANAAAPNRATPTGPKNGRVQPALPLQGPTVAKMPLESKAGNVAQPPSSSTLVDATQAATAAVAAAMAKLPNANGSAVDHLAKKVNEMRVNDQTIRAPRQPGAGGFNTGNRGRGRGGARGETRKVDVPTTDFDFESSNAKFNKQDLVKEAIAGSPLGEAPPVPEAVEEKPEVPTSGYNKSTSFFDNISSESKDRAEAAGGRPGGREWRGEEQKKNLETFGQGSVDNGYRGRGRGRGRGRGRGYSSNYRGRGGRGNAQPTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8TAH8</accession>
    <name>A0A3D8TAH8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">RuvB-like helicase</fullName>
            <ecNumber evidence="15">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BP5796_01104</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="15"/>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8TAH8"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002221">
        <property type="entry name" value="RuvB-like 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000002">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0010">Activator</keyword>
    <keyword evidence="7 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 15 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 15" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="68"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDW95341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="470" mass="51416" checksum="F2EBF00C9AE03B63" modified="2019-01-16" version="1">MAAQITTVSEGKELRGLNLIAAHSHIRGLGVDPDTLEPRSSSQGLVGQEKARKAAAVILQMAKEGKIAGRAVLIAGPPSTGKTAIAMGMAQSLGSDVPFTMLASSEIFSLEMSKTEALTQAFRKSIGVRIKEESEMIEGEVVEIQTDRSVTGGAKQGKLTIKTTDMETIYDMGSKMIDSMTKERVMAGDIISIDKASGKITKLGRSYAKSRDYDAMGVDTKFLQCPDGELQKRKEVVHTVSLHEIDVINSRTQGFLALFSGDTGEIRSEVRDQINTKVAEWKEEGKAEIVPGVLFIDEVHMLDIECFSYINRALEDELAPIVIMASNRGNSRIRGTNYRSPHGLPLDFLDRVVIVSTHAYQGEEIQQILAIRAAEEEVDVTPDALALLTKIGQEAGLRYASNLITTSQLVCAKRKAKQVSIEDVQRSFQLFYDPTRSVKFVQDFEKRLIGDEGFVNLSVTNGHGDAMELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q3U5</accession>
    <name>A0A3D8Q3U5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Short-chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_13160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000026">
        <property type="protein sequence ID" value="RDW56519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q3U5"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF283">
        <property type="entry name" value="RETINOL DEHYDROGENASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW56519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="359" mass="38929" checksum="A45BD8B28E7CF209" modified="2019-01-16" version="1">MTATTHPEFNGQTEGLEVAKAFAEAIHGKTVVVTGVNRGGIGFSTSEAIASQSPAQLIIAGRNLSKIQECIDALKTQFPDVHYRPLHINLSSQQSVRTAASDLLFWSDVKTIDILVNNAGICLLPERTISENGIEMHFATNHIGHFLFTCLVMPKLIKATEGSPKGATRIINVSSGSPIMASMRWSDLNFEKKTKDLPETEKPSYRMHTAWGTEDLENKSYIPLEAYNQSKVANVLFGIAANKRLYKKYGILSLALHPGVIKTELGRNASPETLAAVRKMMEKGEVSYRTLGAGASTSLVAALDPKLGVGKIGAGGGENYGAFLVDCQISDKAHPLAVSSEEAEKLWELSEELVKERFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q5H0</accession>
    <name>A0A3D8Q5H0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell surface protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12994</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000024">
        <property type="protein sequence ID" value="RDW56927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q5H0"/>
    <dbReference type="OrthoDB" id="5418436at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021476">
        <property type="entry name" value="Egh16-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618:SF4">
        <property type="entry name" value="CAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618">
        <property type="entry name" value="SURFACE PROTEIN MAS1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11327">
        <property type="entry name" value="Egh16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017692676" description="Cell surface protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW56927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="21893" checksum="A20415A9B976502A" modified="2019-01-16" version="1">MFSKALLIALAASPLVAAHGKIAVMTGDAGGNTTGLGIQGGVVPGPGSNKVTEVDTTVFKSKAAASDGLGKTKAGPNTLAGMSAVMAQSGNTLAQVTPGGSLSGTVHIVTTDGAGPYTAIADPTGTGAFSTGTQMTVTTQVPGTKGNIAAPKQRGLITRTLVNLGIVKRASNVNEDYPIAISVPAGMTCSGTVAGQSNVCLVKIANPSGAGPFGGVVAMQMAAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q676</accession>
    <name>A0A3D8Q676_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BNR repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_12773</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the glycosyl hydrolase 74 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q676"/>
    <dbReference type="OrthoDB" id="2151161at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010411">
        <property type="term" value="P:xyloglucan metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052025">
        <property type="entry name" value="Xyloglucanase_GH74"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43739:SF2">
        <property type="entry name" value="OLIGOXYLOGLUCAN-REDUCING END-SPECIFIC XYLOGLUCANASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43739">
        <property type="entry name" value="XYLOGLUCANASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017632198" evidence="7">
        <location>
            <begin position="29"/>
            <end position="821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW57323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="821" mass="88263" checksum="0C8CB67CC5F42B94" modified="2019-01-16" version="1">MMVGDRFVAHRLSAFIISLASLITFGSCAHNDGTKAHPYRFNSVAVTGGGFITGLFGHPTEPDLLYARTDIGSSYRWSRAAQQWIPLTDFISEANINLFGTESLALDPSNPNMLYLAQGQYTTSNNTAFFVSDDQGKTFSIYPAPFPMGSNELGRNNGERLAVNPFNPKELYFGTRTEGLWKSIDQAKTWSNITDFPDAFANGIGIVFVVFDPKHNGTIYVGGNVPNGIYYTKNGGISWNVVPGQPTTWTDDVLIFANSTPTSPPLSDGPQPMKASLASNGVMYVTYGDGPGPYGVSYGIVQKFHTANFTWTDITPGLNNSYPPPYTPQAFPRGGYNGLSVARDDPNTLVVISLDRDPGPAIDSMYYSRDGGRSWKDVSQLSSPPVSDGTWGHPIQEAALKNGTAVPWLSFNNAKQWGGYGAPSPNVGQTKFGWWMSAVLIDPHNSEHIMYGTGATIWSTDTISHVESNSAPSWYIQAQGIEMTAILDLISPTTGANLLSGFGDINGFRHSDLFTPQPMFGSPTFSNLDCLDWAGRKPNVIVKVGSTGLPFVDACPMAAISTDGGLEWDRFPNCAPMTNNSFQTGGLIAVDASGDHLVWTTGGLLKFRNDTGPYYSSDLGKTWDAPTGLNIGTGNVSSDKVQPKTFYAYDSGIWYVSKDGGATYSSSIAADIGLPENTGAVPVVSFKAAGEIWLPLGNEGVYHSTNFGSKWTKIGSEGVSTSMFSVGAPAPGRRNPALYLWGNTTAGADAVTGLFRSDDAGSTWVRVNDEAHQYGGPRLILGDPRVYGRVYQGYFGRGIIYADIDTESHGTATVRPGTYGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q6D9</accession>
    <name>A0A3D8Q6D9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Reticulon-4-interacting protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q6D9"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05289">
        <property type="entry name" value="MDR_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050700">
        <property type="entry name" value="YIM1/Zinc_Alcohol_DH_Fams"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11695:SF294">
        <property type="entry name" value="RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="8"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW57386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="317" mass="33791" checksum="DB535325558F0F12" modified="2019-01-16" version="1">MKAIQIMGDKDAPNIKLSDTLPRPVPKEREVLIKVFAAGITADEVTWPELYTTSNRVPGHDISGIVEGLGPEYSGSLLIGDGVFAMLRANTSQGGQAEYAIASPDEVALKPTSLSHGEAAALPIPILTAWEAIFTHAKLQKGAKILVTGASGAVGLMLVQTASHLLGAEVTGLASPENHARLKELGASQVLDYKSSNWEQMIDNVDAVFDTVGGAVLDRAWETVRKDGVIVTVSDPPPPWAFGEGKPSQLQNHPHVKWIYFILTPSSESLEAVAALLDEGSVKPLEVKIFPAENALEAWTYAGQRGRQGKAVLQFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q7J9</accession>
    <name>A0A3D8Q7J9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_12616</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q7J9"/>
    <dbReference type="OrthoDB" id="3477286at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="3">
        <location>
            <begin position="116"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="596"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW57815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="858" mass="96789" checksum="49E32611807C5DA2" modified="2019-01-16" version="1">MSASDPETPERSNTPEPTLHRARTNLNAPGLETGVFEQGDKARRNFRRIANTALNKKPGRKENTYAYKNIDYDRQIRVLKIYRGRVGDALDCCLLASSLLNTDDLTYLPLSGHIPYIALSYHWGTDDAKYKVYLYASDDAYAKVKSWGPTARHGVRLELNSYILIQDNLKSALEALRSVDSDVCVWADALCINQSNGEERTAQVSRMHEVYSQADRVCIWLGGRRDAENQKTFDFLRSILNLERLDDFFKGVSNKEQKDLEDCKRVIDLMKSEWFTRRWIIQELALATDAYVRCGSCEMDWTEFGDSIALFMTKYDRIRRAFGAQSTTYSGSWDSDSHSLRALDARALGANLLVTATSNLFRRSNEGKILQRLISLEVLVSSMLLPFEAKDPKDTIFAVLHIAKDTYKPGSSTEHGHPVQTVIKILGRCLILIPVLVATWKSSTFAGIVGVLVGPTRVKNSTVDVQLIGKSPDDSNNLLLNSFISTLIQVIFLIICVMSTDIVIKRGILPFISPPASSRGISTKITKPIDKRIEPNYDKCLMDVFSDFMEYCVEYSNSLDILCRHWAPLRERDPKPSWILSVEGHAFGGPRNNVKARRNGDSFVGGSERRRHYRASGSRTPDCRFEKTRAVKGNVTKRIKQEPGRYTEPITKQSELPARFTGKLEVKGFVLDEIDQYAAVLDGVISRKALEICGWSKENGTTDIDQVWRTLVADRGPDGTNPHNWYRRACRSCLEWYNNQPDDFFNTSYLKSLNNTPSAKIEFLDRVQQVTWGRKVIRSTGNTGNTRSRHFVGLAPSEARVGDLISILFGCSVPVILRRRKTGGEFTFIGECYIDGVMDGEAIDAMPSGSKEQWFGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q7X8</accession>
    <name>A0A3D8Q7X8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Wax synthase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_12598</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q7X8"/>
    <dbReference type="OrthoDB" id="1077582at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032805">
        <property type="entry name" value="Wax_synthase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13813">
        <property type="entry name" value="MBOAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Wax synthase" evidence="6">
        <location>
            <begin position="258"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW57797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="285" mass="31982" checksum="A2514963F2500FBF" modified="2019-01-16" version="1">MGLLVPLDSRSPLPTLAIPYLYFLLIATLSLPQGWYRARIVILLAAYICHLLNHTTGSRVSDYGTGCAVAQIFFKFADYVVLSNAETEFSRHSLGDMTTYEGASELDQSKLADASGMLSPWQAFFKKFRWGLELSVTARGIGWSWQVKNVPSSTASAASWTKSDFHEVFSRHLVYFDLSNCIFVLKNIGRALIFVILIRLRACILTSYPASTFHSSNVVVQSLLCFIYGSKTAFGLNMMYAIAAAITVSVGIYDPCDWPPVFGNFADAYTLRRFWGQSWHQMERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q8W1</accession>
    <name>A0A3D8Q8W1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3b domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q8W1"/>
    <dbReference type="OrthoDB" id="2251794at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017766836" description="SH3b domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW58272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="13692" checksum="3D1BA79327043C6C" modified="2019-01-16" version="1">MKFTTVAITIFLPLFVLASPAPVPNAAEPTLPITLAPRAPDGLLEKRSVAATVKADGVRHRICPRVSNSCPANGQYAKGTKIRLDCYTRDNTTPVDGDYGWARITSNGDWIALAHGNYVSWSAQRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q8Z5</accession>
    <name>A0A3D8Q8Z5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative HC-toxin efflux carrier TOXA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_12211</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q8Z5"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF153">
        <property type="entry name" value="AFLATOXIN EFFLUX PUMP, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="354"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="55"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW58281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="549" mass="58729" checksum="7CE4DE0493B431E3" modified="2019-01-16" version="1">MKLASYRRLLGMDDSFYENTAGEQHINGKLEKGPSPIREVEDESKYPPLKTMLLSMLSIYFSFFLVSLDRTIVGVAIPAISNEFQSFSDISWYEAAFLFAFCVLQFPTGKIYTFYSAKWTYIVLVAVFEIGSIVCAAAPTSAAFIIGRAITGIGGAGSLAGASVIMTELVPLRKLPKYQGLSGAIFGLSSIFGPLVGGLLTTKVSWRWCFWINVPIGGISLAGLLIFLPASTPPDEIKGTFQQNLWKFDPVGNIVLAPGLICLLLALQWGGTKYPWSDTRCIALLVVGSVLLLAFVGVQWVQENGTIPFRIIRQRSIAAGVFISLGLGAALIIPTFYLPIWFQAVKGTTAIDAGIRLLPLLLGTVFSVIGSGIVISKSGYYAPWLIVGCAIRVIGAGLLTTLRVDTGTGAWIGYQIVVGVGTGMTLQQCVMAAQTVLAKRDVPMGLTIITFAQFFGGTISVSICQTILANTLASELSKKLPGFNASAIASAGATEIQGLVLKEELPIVLAAYNAGIDNAFYCALAASCLALVASFFVEWKSVISRPRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QCL0</accession>
    <name>A0A3D8QCL0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_12078</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QCL0"/>
    <dbReference type="OrthoDB" id="3598904at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF4">
        <property type="entry name" value="HYPOTHETICAL CONSERVED PROTEIN (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW59154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="479" mass="53997" checksum="AFC26340432E0E1A" modified="2019-01-16" version="1">MSGTSISLPKRTRARVRKVKTGCHTCKARHVKCDEAKLACLKCSNSGRTCDGYGTVLVSLEEALAAVDSLPQSFRNSQEQRCFEHFRHKAVPELLGYDRGPGFWNGLVLQLSQCSPAVMHAMLALNTLYEVHPTPTAKKSTEFDRRFLQQYNKAIRLLCSPQSTESVESILSCCILFICLENFRGNHEIALNHLRDGLKILHDWRMKEGLLASERSIQEVIVCIFRRLDIQATTFLDSRKPELDITLAFGSPTQPYNYNTESFANLHEAKICLDNILIRLLYTLTSVKSPRQHPPLPGQQNRMVSARRDVLQGLAAPLSQWKDAFDDLVMREKSNMETKDLQLSVLLALHHQTMLLMLRIRVNETSDAQSQTVIKDAQFEKTIHLSKSLINSSSATQENSYAADSGVIAPLYFTAMNASNPHLRQQAIELLRLVKWKEGFWEAEVAATIAENILFIEENGIKGIMVTGGIPELAKLHYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QEF5</accession>
    <name>A0A3D8QEF5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycerophosphocholine acyltransferase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BP5796_11656</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GPC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QEF5"/>
    <dbReference type="OrthoDB" id="406287at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006656">
        <property type="term" value="P:phosphatidylcholine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021261">
        <property type="entry name" value="GPCAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201:SF1">
        <property type="entry name" value="GLYCEROPHOSPHOCHOLINE ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31201">
        <property type="entry name" value="OS01G0585100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10998">
        <property type="entry name" value="DUF2838"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="248"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="505"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="96"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="521"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDW60050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="536" mass="60638" checksum="84B09C19540B668A" modified="2019-01-16" version="1">MSDPIAIPDSKPESVMAGGLPSDASRNLDAATPSSSSPPDGSKSPILSSSPSSPKLSRAPSFSGSSSYQEDWEAFPPLERLTVFDILDNFALPAQLQKLQNNISAQTEKVRKQRDALKSRTSYTRAKVVEEWRKRVPTADEQLDRYRKKMKVSVDRVVNRWEKTATISLREKLSFICGVINVLISGYLIGGYPEYFHIWYTAQLLYFMPIRFYTYQRRGYHYFLADLCYFVNFMCMCTIWFFPKSKRLFISTYCLAFGNNAVAIAMWRNSLVFHSFDKVTSLFIHIMPCVSLHCLVHLVPDALQKARFPAVWAIRTSAPGSKEHYSLLAMTLWSTIPYAVWQLSYHFLITVRRREKIAAGRPTSFTWLRKSYSKAWIGKMVLSLPESLQEPAFMLIQYSYAVSTMLPCPIWFWYRYASAAFLMAIFCWSVYNGATYYIDVFGKRLQNEMEALKKEVAKWQNSPDMAHSPLMTPKVEGVTDLGAVAGSDTDAEGSIGHSRSRSVDHIPLLNGESGATGLDGGARDVAKERKIGELPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QEN5</accession>
    <name>A0A3D8QEN5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha-L-rhamnosidase six-hairpin glycosidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_11918</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QEN5"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987:SF4">
        <property type="entry name" value="ALPHA-L-RHAMNOSIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987">
        <property type="entry name" value="C, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017692362" description="Alpha-L-rhamnosidase six-hairpin glycosidase domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="2">
        <location>
            <begin position="415"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase C-terminal" evidence="3">
        <location>
            <begin position="760"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW60312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="855" mass="93889" checksum="D9B472F0F040F46C" modified="2019-01-16" version="1">MIFGPRTLLAACFTRVVGAGPWPSIPLRQPSSSPTGAVYVHPASIANTLTDAYINGSAGDPIVFTTVGQTYTLDYGRDVAGYPIFEVAIVDGYAQIEVKYSEAYNGLLQSQSDGPFAFANGLAGTFRVETFNLTHTGNVSSYFIQGSQRWQTITLIKGKHLQLSSVGFKSSVQQTPLDSWGGYFASSNATYTDIWALGPYTQQLVCFAPGTQTSTWEITENGAYIRGQKPATTGQVVNLKNYTLSFETMIEYGGTGWRVDTEIDAIQATGPIFILTSEYPDGSFANIDQSLVPPNTLVVGRGWSLQNQTSLPGYILDKFPISVNVTEKVWHTIKTTSPGDNTYTVLLDGLEIAHFNISSYGVGDPNPYIPGGIYKSFAFGPWQDQAAYVRNANVVLSTGETVYNNPMTSDDVLVEYGVQTNDRYTCSDSGKRDRFSWLGDRLISARAVMAGTGDAQFVWGPAEEAFSRQISSGQIPINTLFSPLDTEGTLIRTMNLDPLLVDYNFDFMQVILNYWMSSGNDTFLQYYWPKMVSATSYAISRSLDFDTQLYGALSAPQNVPLASEKGQALGPASTISLILGLEKMAIMASYLKDNMTAKAYRKQAELSRIAIDTLLWNSTDRYYASSVGVSGYDLMDIAQVLLAEVGTVERRAQFLEKLAPLKVTAGYINGTRYEDTPGVVNPYYMSFLLEGLAKFGETELAQDLLDSTWSPMVIKDRNYTGAYWEYVSIDGVYPGLDLFTGQSHFWGSYPTVFLTEYVLGIRTLEPAFKEFLFAPLPGFRTEWVHGRVPTPSGAIYAAWGYNSDGKIVLEINAPDGLVCIFVPPFNGSFSYGEEVGVTQNATIISRNSTITIVED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QIA0</accession>
    <name>A0A3D8QIA0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative caleosin-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_11407</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the caleosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QIA0"/>
    <dbReference type="OrthoDB" id="640742at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007736">
        <property type="entry name" value="Caleosin-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31495:SF0">
        <property type="entry name" value="BINDING PROTEIN CALEOSIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G13750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31495">
        <property type="entry name" value="PEROXYGENASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05042">
        <property type="entry name" value="Caleosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW61515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="243" mass="27543" checksum="60F4C852E356144F" modified="2019-01-16" version="1">MAPARITVDGFDTGIEEVPVTEARTPFIQDRGNEVLRQPGTARANQAASVEAPNGTLPGPYSRRKHQTVLQQHCAFFDRDGDGVIWPLDTYRGFYALGYGFFLSMVALVIIHSNFSYPTLSGLLPDPFFRIYIDNIHKDKHGSDSGTYDNEGRFIPQKFEDIFAKYASGDKQSISGQEIIDYLKGQRVIMDPIGWFAAIFEWLATYILLWPADGRMQKEDIRRIYDGSLFYEIAARREKGKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QIF6</accession>
    <name>A0A3D8QIF6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RmlC-like cupin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_11514</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QIF6"/>
    <dbReference type="OrthoDB" id="10261807at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02910">
        <property type="entry name" value="cupin_Yhhw_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43212">
        <property type="entry name" value="QUERCETIN 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43212:SF3">
        <property type="entry name" value="QUERCETIN 2,3-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin N-terminal" evidence="4">
        <location>
            <begin position="20"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006232-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW61622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="284" mass="31148" checksum="E5D59B7AF9884E0B" modified="2019-01-16" version="1">MSKALVNAKIVPRRSSDRGHANHGWLDTYHTFSFANYYDHKFTNYGSLRVLNEDRVSAGQGFPTHPHRDAEIFSYILSGELTHRDSMIQKGKEGAQGDDFFRMKRGDVQFTTGGSGIAHSEQNEGKKTVHFLQIWALPWARGLTPRYHTKTFPEEAKRSAFVPILSPLKAGPQATAAEETAAEPTLPDTIPIHADLVMAAGIIGVDKRFKWTVGANAVKNTSRRVYVHVPMCKSGSAKVRVDGREEAVLGEGDGAFISNVHAGDVLSFESIGEAEAEVVVLDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLK4</accession>
    <name>A0A3D8QLK4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_11005</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLK4"/>
    <dbReference type="OrthoDB" id="3545167at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW62703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="247" mass="26423" checksum="9F102751112BCD11" modified="2019-01-16" version="1">MAAQDSEVAHPPTIGGNSTQVNTRISTFKRHIVRNQLWLAALAVILVAGMIVGIVFAIHDHYHSFGGQGWLKARNPKQQEDAARLYLPLQRLEVQPTGVQWSPWYGWLKRSPTNPPFYTCGDQRNICCPVGLICQPTSSTPSKVYCCNATDDSNCQISKRLPMCLGQTVECPAEVGGGCCSPGTACSPSGCVKAETRGPSTAHAPVATTPKEGEVAQNTGTTNSLVLGPRRGCAGALFLLAVFMARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QM32</accession>
    <name>A0A3D8QM32_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_11161</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QM32"/>
    <dbReference type="OrthoDB" id="7608935at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071039">
        <property type="term" value="P:nuclear polyadenylation-dependent CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051644">
        <property type="entry name" value="TRAMP_AT-DNA-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46543:SF1">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="9">
        <location>
            <begin position="643"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="737"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="116"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="176"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="774"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="811"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="823"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="885"/>
            <end position="896"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW62859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="896" mass="98083" checksum="6CEB3EA392E14689" modified="2019-01-16" version="1">MPSSPDDNVDSRTSGVGRKRALERESLGNDTIDDSDDDTFQPQKRLKADSVDVDDEPSFIEAGVQSRKLSTDEPQIPSAPQTHPSPSDTAGLPSSTWNQSVQSGLRTSFGRKKASPLQSRPTPVETQEVTPSAAAEATLSRVTSFSTPDLPVADEHDAEVESETDVVNPNIEKDGSNTNTTSSDCSLSAAANASHIASDGRTKKGAKLYAPILRKLRAEVQNSDIPIPKKAIQAEARALAAGPPEEAEKAIQSFVQRYQQQTETAAEAKVSRKAARKALKPAFPNAIVPQAATPRTTEYDGLSEITEGFRTHPGSSRQYRNRDGVYYLREIVTDSRTEPIKLEQLSFRIFIPLFVWDNLETLCSNLNKLNVQMFSGAFACYVSAFYDKKNMALEEKIRAEGKDESARTISQGMIAAILEEAYKAKGVPSRTPSLWEKLIQVIDKIQADALSPLAKVEMTAQAEKVEAEVTETHASAAPTPAAIVVPTPSLSEMGVESSDDEYSHAAEETQMGAAIAKQPTHEDIMLQEKYFPVPSGQEVLHLCLACAGSGHHVDTCPSMVCKKCGARDHPALFCPQNKRCGKCRDLGHERLECPEKLLAARTEAVPCDLCKSVEHIESACPILWRSFQLSGEVKKIHELQIHCFCCGGTGHYGLECGLHKGPVLSGHRTWSKKNWVQFVDFNSKERALSAGVDYSIKPKEAKGFNIKGRANDPIELDDSEEDSSSFIRPKVNSAPARRGHIKFGGQNRIDNYPPRGNGYDGRIATQAIPRSGRGYRDESGRYGREREFSPPPRFEEDRYFQAGNFEHEYRQPPQSYPPQSQSFRPTGSSHFDNPPRQSSTFNSSKPISIPLSQGKNSNKRKKNAPVPAPGPGPGAKKARSRKGRGGNARGGMNGRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QMW0</accession>
    <name>A0A3D8QMW0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Uracil permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_11096</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QMW0"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000001">
        <property type="entry name" value="Uracil permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012681">
        <property type="entry name" value="NCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00800">
        <property type="entry name" value="ncs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF2">
        <property type="entry name" value="ALLANTOIN PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="339"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="548"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="576"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="19"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="19"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW62794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="651" mass="72177" checksum="62BDF7F31BE687AD" modified="2019-01-16" version="1">MPGLQDGDAHSIHILSSRLPSPQGLLSSARNSCRHSEENEPLLAGPSTPTYSRRTSEDRLSREAVRRLLENNSQSRTQQRDNLRYSEEEPYFFNIIMTKVRTTKVGQFIEKLAVESEPGLSTTQLMLHNHDLKPVEPERRQWGAWNFVGFWVADSFNINTWMISSSMISTSGLSWWQSWLCVWIGYSIAACFVCLTARIGATYHISFPVLSRSSFGIWGALWPVLNRAAMACIWYGVQAWIGGECITLMISAIWPSYQNLHNSIPNSGTTTYAFVSFFIFWLLSLPAIWFPVHKIRHLFTVKAYVVPTCGIAFFIWAIVRAHGIGPIVKQTNTAHGSKLAWGIITGIMSAIANFATLIVNSADFARFARKPSDALWSQLLTIPIGFAVTSFIGIIVSSSSTVIFGTSIWNPLDLLQSFLNEGTSANRAGVFFIASAFALAQLGTNIAANSVSAGTDMTALLPRYLNIRRGGYICALVGLVMCPWNLLSSANNFTTYLSAYSVFLSSIAGVIISDYYFVRKGYLEIKELYSARNNSPYYYNYGIHWRGYVAYIAGILINIVGFVGAIGKNVPVGAQYIYNLNFFCGFIVAAAVYWSLCTVSKVPATSDVWCEVGNEIEDPSMAYGYDEEQGVVDGKSHEVISTDKKAETSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQQ5</accession>
    <name>A0A3D8QQQ5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_10482</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW63980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQQ5"/>
    <dbReference type="OrthoDB" id="17458at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050817">
        <property type="entry name" value="DjlA_DnaK_co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24074">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DJLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="62"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW63980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="291" mass="32745" checksum="D2CE110F6DB9BE6C" modified="2019-01-16" version="1">MFKKSGTLVSSLPKIRCLYSPIPISKTSPCGHPKAQQLQCRPYAIISGGHSSHQHDGLRWPEVTSANAIPTPYQIFNQKKGSKYSKKRFYELVKLYHPDRHEHNLSNDGLSYESKVERYRLVVAANNILSDPVKRGAYDRYGAGWNGQPGVSSSRNSSEDSSGWGDTTGWAGGPQGPSQNATWEDWERWYEQNTKGPQKPIYFSNGTYVMIVLAFTIVGVFGQYTRLGGSSVSLLEQRDIIHQEMSKELSRRRMETTTNFGSREERIGSFLKQREPVVHPAKESQDGKDPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQS3</accession>
    <name>A0A3D8QQS3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">14-3-3 protein-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_10668</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 14-3-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQS3"/>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000002">
        <property type="entry name" value="14-3-3 protein epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="4">
        <location>
            <begin position="5"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="232"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW64166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="273" mass="30748" checksum="7A572545FF743F24" modified="2019-01-16" version="1">MTTERESKTFLARLCEQAERYDEMVTYMKEVAKLGGELTVDERNLLSVAYKNVVGTRRASWRIISSIEQKEESKGTDKHVATIRDYRQKIETELEKVCQDVLDVLDESLIPKAESGESKVFYHKMKGDYHRYLAEFASGEKRKVAATAAHEAYKNATDVAQTELTPTHPIRLGLALNFSVFYYEILNSPDRACHLAKQAFDDAIAELDSLSEESYRDSTLIMQLLRDNLTLWTSSDSGEPEAAAAEAPKEEKAAETEAKPEEPKTEEAPAPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QTT6</accession>
    <name>A0A3D8QTT6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QTT6"/>
    <dbReference type="OrthoDB" id="3540523at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW65195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="415" mass="47492" checksum="4EE43D368E976BDA" modified="2019-01-16" version="1">MSFSHLPNEVLLHIVRNLSRFSDLCTCSLISHTFLSVARPILYREIEITSAADDFDDEDDGAIMARQAESLKTISENAYIGSLVHKLRCRDTKSTTYSDLIVVEDYLDLQDIVQAAKNMTSSVKSLATAVAATCPMLKSFEIVGGFSDRPDPRLILPKSTYDNSTQYELMTGGLQFPHLEHFGLSNLRFILYESNGNQKIKDLILQLVQSCGQTLISIRIPILFSADRTELAFIMKLSFIRELPPSLEELYIEISAESLLVDEDDDFNPFCSIGEDIFGALKRLHTCDLMAWICDADLTTASYPGKAVHYRRLRHAKGEQYKSLWTSRQDRIYPKDDFVITHSSVEIQGEFEGKDAKNAWLDANEEGELEYSKYIDEPKTRQFKALEDNEARRWPHNQSRHYQDRVKSYEMYEIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUF9</accession>
    <name>A0A3D8QUF9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA polymerase</fullName>
            <ecNumber evidence="11">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_10099</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the DNA polymerase type-X family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="11"/>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUF9"/>
    <dbReference type="OrthoDB" id="205514at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.210.10:FF:000005">
        <property type="entry name" value="DNA polymerase IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000010">
        <property type="entry name" value="DNA polymerase lambda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000005">
        <property type="entry name" value="DNA polymerase POL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019843">
        <property type="entry name" value="DNA_pol-X_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018944">
        <property type="entry name" value="DNA_pol_lambd_fingers_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF29">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY PROTEIN POL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10391">
        <property type="entry name" value="DNA_pol_lambd_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00869">
        <property type="entry name" value="DNAPOLX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81585">
        <property type="entry name" value="PsbU/PolX domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00522">
        <property type="entry name" value="DNA_POLYMERASE_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="13">
        <location>
            <begin position="168"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="74"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW65407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="659" mass="75070" checksum="2D57A3181223E13D" modified="2019-01-16" version="1">MALNFPRIFLLKHRIPARERLELEAAIGAPPLVWAIKEAQIVLGVVPTKERAEFELRKEKVWTEEVTRHEPVVTGATRKRKRKDAPPATKHRRVRGREDVTATETITIDSSTESEAEAIVERTSHQSQTSKPPSWPNEGANGPTLPEDVSSPVTLDEEETELVRDDTIKVVKLEWYRDSVTAGRVLPITKYLIYEGRVRPRPQSEPDAPKSTTIPRSEKLLLRARADALYVDKSDVSKNWNHGQKSSEVSVTRPTHLLHQTTSEHEQSFKLPPIPDFLHTRYSCQRPTPLHSPNDPFLRQLKKIKQARILNDDKTGVRAYSTAIASIAAYPYTLTSVEEIYHLPGCGDKYAAVFREWKETGRVQEADLIDADPRMQVLNEFWNIWGVGDKGALSLYNKGYRTLDDIVEQEWNQLSRVQQIGLKYYDEFLQKIPRAEVEAIGTKILEYANKLHKGFEMVIVGGYRRGNMECGDVDVVLSHPDEKATLFFLPDLTSKLEQHGWITMNLIESVKNSERGQEPVSWKGNSEGTGLAGGGFDTLDKSYVVWQDPDWPTKESDLARNPKAKNPNVHRRVDIIISPWKTAGCAVIGWSGGTTFERDLRWYCKYEKKWKFDSSGVRNRADGRWVDVEDCPGNLLAKEKRAFERLGLIWREPTERCTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUG9</accession>
    <name>A0A3D8QUG9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">3-oxoacyl-(Acyl-carrier protein) reductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_10185</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUG9"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000173">
        <property type="entry name" value="3-oxoacyl-[acyl-carrier protein] reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF127">
        <property type="entry name" value="3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW65493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="253" mass="26440" checksum="0552D465DA4A8C27" modified="2019-01-16" version="1">MAQNDIKGKLALVTGASGGIGSACARSLAAGGAHLALTYSTSLSSLETLVSSLKSDYPTIHISTHQVDLASPQLITDLYTSIATAHAGATVDILISNAGYGKRIVNVWEIPVEEFDYTLDVNLRASFLLVKGCVEGMKEKKWGRIVFVSSIAAYGAGLNGCHYAASKGGLTAMMKNLSSHLAQFNISVNDIAPAMIGATGMIPNADTVPGLVDSIPLHRLGEPEECANAVMMFVKTGYITGQSLLLAGGLMHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QZ02</accession>
    <name>A0A3D8QZ02_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_09640</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QZ02"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000003">
        <property type="entry name" value="Acetyl-CoA carboxylase biotin carboxyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000028">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF33">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0092">Biotin</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="12">
        <location>
            <begin position="73"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="11">
        <location>
            <begin position="189"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="10">
        <location>
            <begin position="663"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW66891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="744" mass="81776" checksum="EC406AB640AEE85B" modified="2019-01-16" version="1">MDRKRESSNNLKLAIVVLSHSKTNPEHNHLSLPALHAFPMIPATKTRALARAIFASHHRPLSTNPTSIFTSTPITSVLIANRGEIALRVGRTASALGVRCTTIYTDPDAQSQHALSSPFAVNLGTANAYLDGERIISVAKEQGCEALHPGYGFLSENSTFAKRCVEEGIVFIGPPWKAIEAMGNKSRSKEIMIEAGVPCIPGYHGLNQDPDHLLQEARKVGFPVLIKAVRGGGGKGMRIAMHEREFLGMLESAKSEGRNSFGDDEMLVEKYITTPRHIEVQIFADRYGNAVALGERDCSLQRRHQKILEEAPAPNLAEEIRQDLWEKARAAALAVGYEGAGTVEFIFDNNTNEFFFMEMNTRLQVEHPVTEAITGEDLVSWQFKIAAGEPLPLTQDTIAQRISERGWAIEARIYAENPSQNFMPDSGKLIHLRTPRISDSIRIDAGFIKGDTVSSAYDGMIAKLIVSGPTREVTIRKLYAALQDYEVVGLSTNIEFLKKICKSPAFIKGDVETGYIQKFGNELFTPEPVAPEVFAQAALGLLAKELSTKSLDIGYGPHGQSIGFSPSSQRRFSFLTSSSEKTPTEVMVDQNSPKLFTVTVRGPGIEETYPNIATSFSSSLISSYFPHTRIETTVITDGDKVTLFQHGKQSQLTLTTPSWFEKALGLKDAANSVLAPMPCKILRNEVKEGDQVEKDQALVVIESMKMETIIRSPQCGIVSKLVHKEGDICKAGTVLVLFEENEQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QZ13</accession>
    <name>A0A3D8QZ13_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein-6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_09669</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QZ13"/>
    <dbReference type="OrthoDB" id="153074at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05367">
        <property type="entry name" value="SPR-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000281">
        <property type="entry name" value="Uncharacterized oxidoreductase YIR035C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF8">
        <property type="entry name" value="BENZIL REDUCTASE ((S)-BENZOIN FORMING) IRC24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="5"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW66920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="246" mass="26161" checksum="74DF21319098AC2D" modified="2019-01-16" version="1">MSDPKVIIVTGASRGIGLATARFLLKGSNKVVVVARTAGPLEKLKEEFPGQVEFLAADLADFSVGTQAVSLALKAFSRLDGLIINHGTLSPVKRVADSTAEEWRAIFDVNFFSALAFISPAIPALRESHGRIVLTSSGASVSAYATWGAYGSSKAALNHLALTLKAEEPDITTISVRPGVVDTEMQVEIREKHVELMDATDATKFRGLHADGKLLKPEQPGHVMAKLAVSASADLNGKFMRQVSPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QZ73</accession>
    <name>A0A3D8QZ73_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_09737</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QZ73"/>
    <dbReference type="OrthoDB" id="414540at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01283">
        <property type="entry name" value="cytidine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW66988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="15743" checksum="5823D1B6B34F86F9" modified="2019-01-16" version="1">MSAKEFYLIDYLLAVNRSAPFTMVARSLTATHLNLIAVANKPIDAAPPHSTTEARTTDHTCAAAALASDGRIFTRVNMFHYSTSLCAESTVLAKAAEAGVASAYSTGLIMVDYHPGIEVLVLDSDTGDIKAAGIKDLLPYAWVPKKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R3C3</accession>
    <name>A0A3D8R3C3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">L-serine ammonia-lyase</fullName>
            <ecNumber evidence="3">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_08971</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R3C3"/>
    <dbReference type="OrthoDB" id="7773036at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF2">
        <property type="entry name" value="CATABOLIC L-SERINE_THREONINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="7">
        <location>
            <begin position="16"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW68314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="346" mass="36744" checksum="F24AB1B9E8142851" modified="2019-01-16" version="1">MGSVQQPKSSLPWVETPLIESRPLSEAAGCLRGRSSPGMYFWSKSLRRADADQFRGIGNYVIQRLNSLPDEVTSPRHFYCVSGGNAGLACIVAATSLGHKATIIVASTCHASTIKRLYSMGASAVITYGKNLAEADAYLKNTILKDDPLGIYVPPFDHEDIWAGNATVMQEIGWQMDHADAVICSVGGGGLLCGVVEGLGRLGWNDTEVVAVETAGADSLAHSLRAGANMTLPGITSAATSLGCVRVAEKAYEYSAAPGGAVRSIVLTDAEAAAACVRFADEERTMLELACGVNIAVIYKGILKQVLHRKLMPESKVVVILCGGSNVTLEILEGWREQHGGMFDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R3F4</accession>
    <name>A0A3D8R3F4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09214</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R3F4"/>
    <dbReference type="OrthoDB" id="5125733at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="200"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW68557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="624" mass="69596" checksum="AC68D70FABCF44F9" modified="2019-01-16" version="1">MTTCTLCSSMFSSIENLAMLLTEQGYSYHNLHSLKASVLHGCALCSYIQQEFGLLYDEDENPGFSCRVQFDYWADSEDEEEDGGDGANRPHPFHRLVNGFQVLVYEMSPSGDGSSGSSLVSFLAACPSEDAATRYVTNRPGPLDPRSIENETKIKAWLQEGIGDEAQWARAKPNLSLPTRVIDVEQLCVHVSSPEETGEYACLSYCWGGPQEFLTTRANLESNKKALPFQSLPPTLQDAIHVTRTLGLRYLWIDALCIIQDSAADKAVEINKMGSIYQNASVTIAAARAAKVSDGFLHPRPADEGFTLPFYVNPETTGHITLLPMEEAFEPADPLGARAWVLQETLLSRRQLVYSERDLIWRTQGNQYQTVVTSPRTYASVMEDIPMNLFSPTHRSEFPSAREFTASCITSWSAIVTDFTHRGITVADDRLPAISGVAAVLQRSWKDRYVVGMWESTLAMHLAWRSTDGSLARPPQYRAPSWSWAAVDAPVKFMEVESSHVQILSCEVEPQSPLAPLGSAKNGQLLVRAKLIATADMPLSFQHKYEWKLLFDTKSESLDPGLTYFMLIGFQFGYRAIGLIIREIADEVFERKGLFYHRDDSVPGASNSDIWTRPQVVTKDIKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R3G0</accession>
    <name>A0A3D8R3G0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-mRNA-splicing factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_09147</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in spliceosome maturation and the first step of pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the SPP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R3G0"/>
    <dbReference type="OrthoDB" id="5577072at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045166">
        <property type="entry name" value="Spp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026822">
        <property type="entry name" value="Spp2/MOS2_G-patch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818">
        <property type="entry name" value="G PATCH AND KOW-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15818:SF2">
        <property type="entry name" value="G-PATCH DOMAIN AND KOW MOTIFS-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12656">
        <property type="entry name" value="G-patch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Spp2/MOS2 G-patch" evidence="6">
        <location>
            <begin position="233"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="295"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="315"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU369096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW68490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="366" mass="40590" checksum="98B8014A4419B1A1" modified="2019-01-16" version="1">MAPSQDPEPSAGASTHKIAMKGFSLSARAKPSTSSPKPTSTLLGKRPRAALHHEDSDSEGEARVQHEVVTGFGAEGAIAHEEKKAQGPLVIAKMGNRDWRGEMKRKREQAMGKGKNLLPPEVQARMRGEGKNGPVVEKGNTGEGEPAWGLTVTKKVKVETNEVEEEMVNATVEESEVPVSKEKTDDELALEALMGVKSEKKGPALVIAAAEAQEEGPPLSETDAYRRAIASAPDVSTLEDYERVPVEEFGAALLRGMGWKEGSKVERPKEVKRRQNLLGLGASQLKDAEELGAWVQKADTKRLQSSSGKSSSYGRNDRPPKLSDYRREKERRDERRDERGGGSYRREREREREDYRSRDRDRDRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7V0</accession>
    <name>A0A3D8R7V0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08514</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7V0"/>
    <dbReference type="OrthoDB" id="5232980at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW70117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="361" mass="41850" checksum="C1CD96A40319CB93" modified="2019-01-16" version="1">MAHVPQYLRADEEARIHRQFQGDTWRRNNQVLWTGIFRDEAQRWADEHEMQTLTTAMGPLMDVSHPLCLRNKKSPKAWSKYVKGASAIFAWYISKGESVTVLSPPPPERFHPSGQTNYQVIEEPIVKGVLGTSGVSRIEMVHPTVEGAEDIYYQIWPVDDTTTWTARVGELNVQKPCWRKVKTQKAFSNQLGEMEIAKVHQEAKEKEKGEKKVSQAKATEKTKKEKKEEKKVSQATEKTKKEKKEEKKVSQAKAKATEKEKREKKEEKKVSQATEKTKKEKKEEKKVSQAKAKEKTKKEKKKEKKVSQAKAKKVEEKEKKEKKGKKRVKKTKKEKKKAKKKARKLEKEEKVNYQGRLEPIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8P1</accession>
    <name>A0A3D8R8P1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Polyketide synthase BcPKS8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_08809</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000019">
        <property type="entry name" value="Polyketide synthase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000002">
        <property type="entry name" value="Probable polyketide synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF13">
        <property type="entry name" value="POLYKETIDE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="7">
        <location>
            <begin position="67"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="8">
        <location>
            <begin position="980"/>
            <end position="1302"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="6">
        <location>
            <begin position="2205"/>
            <end position="2286"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="5">
        <location>
            <begin position="980"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="5">
        <location>
            <begin position="1142"/>
            <end position="1302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW70412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="2292" mass="248898" checksum="F3CB6DB758F49ED0" modified="2019-01-16" version="1">MAPSATTWVAPQEGTPRDSEVFMEREESTTSNLAVEDSTKFYTDAYTHGYTEGYVSGYTEAPLSTKQIPIAIVGMSCRLPGNVATPDEFWELLSRARTGWSELPKERFDNASFHHPNPGKRGCFNAAGGNFLKEDLGLFDAPFFNLTAQEATSMDPQQRIMLECTFEALDSAGIPKHEVVGKEVGVFIGGSFSEYESQAFADPDTIPMYQATGCAFSMQSNRLSHFFDLRGPSFTIDTACSSSMVALHQACQSIRNGESKIAIAGGCHLNMLPEIWISYSMSRLFSDEGRSFSFDSRGTGYGRGEGCGMVILKPLDQAIKDNDIIRSVIVGSGINQDGKTPGITMPNGDAQESLMRAVYKTAGIDPKETGYIEAHGTGTKVGDPIEATALHAVFGEERNARNPLFLGSVKSNIGHLEAASGIVAVIKTALMLERGFILPNYDFKKPNEKIPFSKWHLKVPISQRPWPRPKRFASVNNFGFGGTNAHVVLEKAPFIKKNDTDSSESTVQSRKLFVLSANDKNALEAVMKNVGIYLEQRPEIFQSDLMNNLAYTLGQRRSMMQWRLAISTASSFELIQTLNSGKITPSRETEAPRIGFIFTGQGAQWNAMGRELYAEYPVFASTLDACDNYLASQDAPFSLVAELHKDAAESRINEAHISQPACTAIQLALTDLLSSWGVLPTAVTGHSSGEIAAAYAAGILPLTSCMAASYYRGLATQRLKKLYPDLKGAMMAVGCTKEEIEPLIAQLTTKEVRVACYNSPSSLTISGDECAIDELQVLMEEKQMFARKLQVDMAYHSHHMGLVAKDYRNSLHSLEAPKSTQVKFHSSLVGHLIDGSKLEPSYWVDNLAQSVRFSEALTTMCEPVDGYKTGVSMLIEIGPHSALAGPVKQILKSCGANAMKIHYASALVRKRDAVETAQELAATLFVKGATLNMGAINLVEQGKQPSLLIDMPRYPWNHQTKYWHENRMILKHKARTAPRNDLIGTLASYSNDLEPTWKNVLRMDDLPWMRHHQIQSLTLFPMSGFVAMALEAAGQRAASRNVRYDAFELRDISVHTPLMVTGDEVEITIQLRPHQEGTLISSHVWDEFRIHSWASNKGWTEHCKGLIAVRGNATNESESASVVQASKALVQTTISDIKQAQTSAIDKVKMYDALTELGVSYGPSFQGITDCQADDNCAVASITSVETSHDMPQGFQTDMIIHPAFLEQLIEMYWPILGAGRTSVDTVYLPSSIGHMTISRDITKYTATPGDSLRAFCSGLKLPSHPKPIQVSMFATASGDSKDALIMVDDLTIAPIIERGMSSEGDAHRELCYKLDWEPILQPLKSAGNGALHGLTNGHANGITNGLSNESHEYTYGTSHNMNSASGHSDGVVNGDCNAVNGVSYLPDSAVAIVHGQSDSQQQLASKLADLFEKLTNARPDVGTLAEIHTKDKICLFLSELEQPLLATLTPAQFSALQKVLTGVQGVLWVVRGAYVDASNPDANMITGLSRSIRSETLLKFATLDLDSQSVLGSEGTVEAILEVFKATFGPKADANCELEFMERKGSFFTPRIIDDAEMNAYVHKHTKGSLLEPTPFGNNDRALQMVLETPGLLETLHFVDQPLDGTLLDDEIEIEVKAIGMNSRDVAAVLGQLESGVVGSECSGVITKIGKAASFAVGDRVAAISTSQGVYSTFTRAKSALAFKISQDMSFEAAASIPVAYCTAHYALIDLARLSEEDRVLIQGASSASGLAAISLAQTVCANIFVTIDNTESKDRLIKLYGLREDQIFNTSGSYGSILRRVKDSDRFDVVLNCLPTDTDTLREMWASLSTFGRFIEIGEQDVPSRIDTSRFEKNRSFMSVDLTSLAAERPKIMARLLSSISELVNNNKVRPLEHVQVFPMSEAEAALKLLQSGNTGGKFVIAPQPTDVVKATPSLKKTQLLRPDATYILIGGTGGLGRSMTRWMVGKGARNIVLVSRSGSATGKVKELIDELSAFGATVLVRQCDVASSESVDNLITNGLVGMPEIRGVVHGAMVLRDVLFEKMVYEEYNTVIESKVRGAWNFHNALKGAPLDFFVAISSAAGAVGNRGQAAYSAANTFLNAFVQHRIGLGLPASSIDLTAVSDAGYLAENLEAAAEVSKNLGSDTICEAEVLALLGAAINGGLARACNSHTITGMRITPSNPFWTNDAKFKHLRLAAEAAAEAISGSQTKTISYNAALKAATSVEEAEDVVCRGLLWKLPSVLMLEAEDMDATRSLANYALDSLVAIEVRNYITREFEANLQVLELLSSGSIESLSKTICVKSKLVSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R926</accession>
    <name>A0A3D8R926_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone chaperone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08761</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R926"/>
    <dbReference type="OrthoDB" id="4357148at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW70364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="96" mass="10006" checksum="7E52F631B6F800CB" modified="2019-01-16" version="1">MSDDYETSSGDIQNNDYVSRPGQSGIPVQSDSADIGGIEGSQDSDEQLARDDVEAIDEENIIDERTRGAKPSGGYTEPGDEEGLPGPDDGTSAGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RE23</accession>
    <name>A0A3D8RE23_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH:ubiquinone oxidoreductase-like 20kDa subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_08264</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the complex I 20 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RE23"/>
    <dbReference type="OrthoDB" id="268400at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009060">
        <property type="term" value="P:aerobic respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015990">
        <property type="term" value="P:electron transport coupled proton transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12280:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit B 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01356">
        <property type="entry name" value="NDH1_NuoB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006137">
        <property type="entry name" value="NADH_UbQ_OxRdtase-like_20kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006138">
        <property type="entry name" value="NADH_UQ_OxRdtase_20Kd_su"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01957">
        <property type="entry name" value="nuoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005012">
        <property type="entry name" value="PRK06411.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11995:SF14">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01058">
        <property type="entry name" value="Oxidored_q6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56770">
        <property type="entry name" value="HydA/Nqo6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01150">
        <property type="entry name" value="COMPLEX1_20K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 3" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase-like 20kDa subunit" evidence="4">
        <location>
            <begin position="48"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW72230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="173" mass="19677" checksum="294E1711710AF2EF" modified="2019-01-16" version="1">MSCIKPSYYQNGGYKLTTSTTDTSTDVDKFVSWARNGSLWPLSFGLACCSIEMMHVSMPRYDQDRLGIIFRASPRQADVMIVAGTVTNKMASAVRQCYDQMPDPKWVISMGSCANSGGYYHHSYNVVRGVDRILPVDIYVPDCPPTSEALLYGMFQLQKKIRRTKVTRMWYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RHW9</accession>
    <name>A0A3D8RHW9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative allantoinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_07087</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RHW9"/>
    <dbReference type="OrthoDB" id="10258955at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004038">
        <property type="term" value="F:allantoinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006145">
        <property type="term" value="P:purine nucleobase catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050138">
        <property type="entry name" value="DHOase/Allantoinase_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002195">
        <property type="entry name" value="Dihydroorotase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018228">
        <property type="entry name" value="DNase_TatD-rel_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43668:SF2">
        <property type="entry name" value="ALLANTOINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00482">
        <property type="entry name" value="DIHYDROOROTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01137">
        <property type="entry name" value="TATD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="83"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Amidohydrolase 3" evidence="5">
        <location>
            <begin position="425"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW73645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="534" mass="57166" checksum="2E4D5A3251364232" modified="2019-01-16" version="1">METSTAHPYPTPAATPPHDSNVPLTVFVSTRAVIFDEQNNLVLSPVTITTSPQTGTIISILPSILPASSFPPNAIYIDHSPNILLPGLVDAHVHLNEPGRTEWEGFHTGTRAAAFGGVTTVIDMPLNAIPPTTTVAGLKEKVKAAQGQCWVDVGFYGGMIPGNADELLPLVKAGVRGFKGFLIESGVDEFPAVSSADVALALKTLASTPTTLMFHAEMIPPITKSVGDDVQISLPPLAPSGPLTSYSTFLASRPPAFETYAIEEILSLAHLAPELQLHIVHLSAVEGIPLLRAARQSGIKITAETCFHYLALASEDVPEGDTRHKCCPPIRGSTNRDGLWDELLRGDSVIQTIVSDHSPCTPELKLLPEHISHLSGTSCCAPKKGVNGDLTPEQQAEIEKGDFFASWGGISSVGLGLPILWTEAENRKISILDVVRLCAVNTAAQVGLSDKKGGLRPGMDADICVFDPEATFVVGREQMLFRNKVTPYQGKTLRGVVKETWVRGRKVFERDGPNDGFIGKEGAIGKLLLEQRTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RHY6</accession>
    <name>A0A3D8RHY6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_07095</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RHY6"/>
    <dbReference type="OrthoDB" id="10069349at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00198">
        <property type="entry name" value="vWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00092">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00327">
        <property type="entry name" value="VWA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="2">
        <location>
            <begin position="553"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="851"/>
            <end position="997"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW73653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1015" mass="113004" checksum="59CD08B9450829EC" modified="2019-01-16" version="1">MPKRKASDASSDTWSVVSTPNKVRVIVAFASDIAQRQTRLVVPVPPSATIIELQQEALRQAENGPVAFREDRLQDVIDINQKQNTFYVATAKAVSVRNEDELIYVRWITPALALEHPSLSLIPTDKDGISKSLTLSMVKQLAYKRVFPQQFFTPRVRLRIFLTVHELPTELFNTTTLDEYGYTGSIEEPLNLFLVPVSQNPEPGKLHTPGAFAHHKPTTLRRFLKVLFNLTHFPPAIEALQILSTKNKLQAGPTAVLTSCFQELALRMVPGELVRNSQASALEGSRQIFAWLFSLYRRSRNEPDIPAAALAQHIQFQDLNGAADVRFSHPGDRREVVEIAVPDNTASGVSAQPDAQAEDDSETMSMVVSTASDCAELSDVEVISDLNASSDTEGFSTADPISKFLLVPTGRYDSITNFYVELRNGIDRPFEQRHCCLLSNDDFSQLMMEANNCQYFQMFAPQELKAKTSVVITMSKEGFVSLYHMRSIPCADAEHCIENAITGRQITNEDPGPAVLSALQPIITQRKSNGTWDLDDWSLVREVKITNEIPEECLVICFDLSWSMGTTLGDNWAGGETKNTFTRLDEAKQVFRNIIARIGACKAHVGLVTFSSNYNIRMSAPFIKPGVTFKDSLEASTCGGNTAIWDALLLAKGMLLPYHARHPDTKLRIIALTDGEDNNSKAGPREVCQALYDSNILLDSIVIGTDVTDDLFTISKHTGGYAFRPTSRELLFQIFLLEPFLNISTRSDIERTPYINYDESTPKDADMPTIFDIPPCKPHPLQHGSFISLSDASRFFTLRSTSLLGNASLPILSGQLPVRGGPDVAADLPSQMNAPSIQLPSLYRSERSGVSFGNLYLDEMRLMVANPCQFMDVYVNESDMSFWKVVMAGPAASPYENGTYVLFVHLTTRFPRTPPAVRLLTPILHPNIKKHGRICHGILANGWDPNFHIYDILQDIYGLLATPEMRDALDELAALRVRTDAAAAQAEIFKYVDKFAKKSRAEWKREILRFGGTRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RI56</accession>
    <name>A0A3D8RI56_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Putative COP1-coatomer complex alpha chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BP5796_07181</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261470at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22948">
        <property type="entry name" value="Coatomer_WDAD_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000002">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000022">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047312">
        <property type="entry name" value="Coatomer_alpha_WD-assoc_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016391">
        <property type="entry name" value="Coatomer_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010714">
        <property type="entry name" value="Coatomer_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF1">
        <property type="entry name" value="COATOMER SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06957">
        <property type="entry name" value="COPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003354">
        <property type="entry name" value="Coatomer_alpha_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5 12" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="144"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="186"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="228"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="302"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="12">
        <location>
            <begin position="346"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="14">
        <location>
            <begin position="441"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="16">
        <location>
            <begin position="713"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer alpha subunit C-terminal" evidence="15">
        <location>
            <begin position="919"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="943"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF06957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDW73739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1311" mass="145534" checksum="13F64CB0A7C18087" modified="2019-01-16" version="1">MSHSSPWPTQAPAVCALGTEHDRCDHNAPAPASHKFQTLNTSPPHNHQLSSCAGRSRLFRTQTSGDSAYQPPPILDARSLSCSSLAAPVNMASSSPNMLTKFESKSSRAKGIAFHPKRPWILVSLHSSTIQLWDYRMGTLIDRFEEHDGPVRGIDFHKTQPLFVSGGDDYKIKVWSYQTRRCLFTLNGHLDYVRTVFFHHELPWIISSSDDQTIRIWNWQNRSLICTMTGHNHYTMCAQFHPKDDLVVSASLDQSVRVWDISGLRKKHSAPTSMTFEDQVARGNSNQADMFGNTDAVVKFVLEGHDRGVNWVAFHPTLPLIVSAGDDRLVKLWRMSETKAWEVDTCRGHFQNASGCLFHPHQDLILSVGEDKTIRVWDLNKRTSVQSFKRENDRFWVIAAHPEINLFAAGHDNGVMVFKLERERPASAFYQNNLFFITKDKQVRSYDFQKNLESPTLLTLKKLGSPWVPPRSLSYNPAERAILVTSPADGGSYELINLPRDGSGSVDGTDTKRGQGNSAVFVARNRFAVFNATGQQIDIKDLTNSTTKTIKPPAGTTDIYFGGTGNLLLITPTAVHLYDIQQKKSTAELAVAGVKYVVWSNDGLYAALLSKHNVTIVTKTLEQVSTLHETIRIKSATWDDAGVLLYSTLNHIKYTLLNGDNGIVRTLDQTVYLVRVKARTVYCLDRNAKPKILNIDPTEYRFKLALVKRNYEEMLQIIKNSSLVGQSIISYLQKKGYPEIALQFVQDPQTRFELAIECGNLDVAVEMAKQLDRPKLWSRLTTEALAHGNHQIVEMTYQKLRQFDKLSFLYLTTGDESKLTRMAKIAEHRGDFTARFQNALYLGDVEDRIQMFKEIDLYPLAYMTAKSHGLTEECESILEATGLTEAEITLPSLGSPLTPPKPVVETFKANWPTKATSQSFFEKALLGQVEGLSLDDEPAAASNGFGFDDAAEDGAKQNGNLIDADDDEDAAGWDMGDDIVPEVESDFVNVDSAEAGAGSSEADLWARNSPLAADHVAGGSFETAMQLLNRQLGAVNFEPLKPRFLEIYQASRTFLPASAGLSPLINYVRRTLDETDPRKVLPIIPRDIESLAAGDLQAGYSAVKANKLEDAQQIFRGILHALLVNAVSTSAEVEEAKKLITSASEYSVAMAIELSRRKLGSNDEVTKSPEKLKRSLELSAYFTIPKLEVAHRQLALQTALKLAFTSKNYNSALSFANRMLANGGAAKILDNARKIKAQCERNPNDAHEIDYDQFAEFDVCAASHTPIYHGSAFESCAFDGSKYQSKYKGTVCAVCGVCEVGKMGSGLKLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIG8</accession>
    <name>A0A3D8RIG8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ELYS-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_07212</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIG8"/>
    <dbReference type="OrthoDB" id="20729at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025151">
        <property type="entry name" value="ELYS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13934">
        <property type="entry name" value="ELYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELYS-like" evidence="3">
        <location>
            <begin position="37"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW73770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="316" mass="35738" checksum="33AD1E39DF6E9D99" modified="2019-01-16" version="1">MYSYQSFDDVFSFDLRCAYDDQAVHDIEVCRKKLEGLFVDKVLKLMGIKRITKIYPPKTNGDLRNLHKAIVDSAGADHHKISVLYYVLLDLDAPTGRRVYSSSLESCSYMPPKYSIYMKGLWHMDRFEFDVALQYLTHPSLIPTFADEILEALVRHAKHGDLRLPLAYYHTVQPALASSSAMESLFSSIARNSVTEAFYFTRSQPEYARRHMLQILIALVVNNSSQKTIASRSMELVNLPFSAEEEEWFEKYLVEGEGRLLKKGKDTLMMRKIGTGKFSEALSVEGASGRTHGGLGWHVIAGGIQDGLGPRMEPLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIN5</accession>
    <name>A0A3D8RIN5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone chaperone</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_07354</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Interacts with histone H3 and histone H4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ASF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIN5"/>
    <dbReference type="OrthoDB" id="29755at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006337">
        <property type="term" value="P:nucleosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1490:FF:000001">
        <property type="entry name" value="Histone chaperone ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1490">
        <property type="entry name" value="Histone chaperone ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006818">
        <property type="entry name" value="ASF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036747">
        <property type="entry name" value="ASF1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017282">
        <property type="entry name" value="Hist_deposition_Asf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040">
        <property type="entry name" value="ANTI-SILENCING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040:SF0">
        <property type="entry name" value="HISTONE CHAPERONE ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04729">
        <property type="entry name" value="ASF1_hist_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037759">
        <property type="entry name" value="Histone_Asf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101546">
        <property type="entry name" value="ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="179"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="179"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="220"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW73912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="283" mass="30509" checksum="93A14F006E4D3BC3" modified="2019-01-16" version="1">MSVVSLLGVKILNNPAKFGDSYQFEITFECLESLQKDLEWKLTYVGSATSDEHDQELDSLLVGPIPVGVNKFIFEADPPDTKRIPDAEILGVTVILLTCAYDSREFVRVGYYVNNEYDSEELNADPPAKPILDRVRRNILAEKPRVTRFAIKWDSDASAPAEFPPEQPEADLVADGDQYGAEEAEEEEEEELAEGAEGAAAADPDAMVDDADVAGAEGDAAAEESDNGSEDLEADSSGSEAEDDLEEEVGEGGADEDMDMDGVEKPAANGTSASHQVDEVMAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJ79</accession>
    <name>A0A3D8RJ79_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Endoplasmic reticulum-Golgi intermediate compartment protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_07472</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ERGIC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJ79"/>
    <dbReference type="OrthoDB" id="270930at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF25">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="8">
        <location>
            <begin position="8"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="7">
        <location>
            <begin position="141"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW74030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="438" mass="48670" checksum="A8B0C3516AF58806" modified="2019-01-16" version="1">MPAKSRFTRLDAFTKTVDEARVRTTSGGIVTIASLLIVLFLAWGEWADYRRIVVHPELIVDKGRGEKMEIHLNITFPRIPCELLTLDVMDVSGEQQTGVMHGVNKVRLNPQEQGGGVIDMKALDLHVEEATHLAPDYCGDCYGATPPQNAQKPGCCNTCEEVREAYASVSWAFGRGENVEQCEREHYGERLDAQRHEGCRIEGGLRVNKVVGNFHIAPGRSFSNGNMHVHDLNNYFDTPIKGGHVFSHEIHHLSFGPQLPDDVVKKIGTKSFPWTNHHLNPLDNTEQITGDPAYNFMYFVKVVSTSYLPLGWEHNSDIMHVSSDHNVDIGKYGHRHDGSVETHQYSVTSHRRSLNGGDDAADGHKERIHARGGIPGVFFSYDISPMKVINREERTKTLAGFLTGLCAIIGGTLTVAAAIDRGVYEGANKLRKIQSKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJF7</accession>
    <name>A0A3D8RJF7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative nop14-like family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_07466</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJF7"/>
    <dbReference type="OrthoDB" id="441771at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007276">
        <property type="entry name" value="Nop14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183">
        <property type="entry name" value="NOP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04147">
        <property type="entry name" value="Nop14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="117"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="319"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="816"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="890"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="180"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="218"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="319"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="890"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW74024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="909" mass="102938" checksum="85F87E9492710E1D" modified="2019-01-16" version="1">MPPSQLKRLKASLREQGIVGPQKSKKQKKQNAQNGVNNEKRVQRNVALTGIREQFNPFEVKTSARGPKFDVTSNKTISGRVTKGVKGRPGVTKGLGEENRRKTLLVEMQRRNKVGGILDKRFGENDPSMAPEDKMMERFTQEKLRRHKTSSAFDLEDDEEAGELTHMGQSLSLDGPNIQDDFDDEGLELSDAEDHPSDEERQRKRRRSGGSDDSGPEGSKDEEDRPERKKSKQEVMKELIAKSKMHKYERQAAKDDDEDLREELDKEMPNLHELLRGIAPRPAPAPLAAASGMNPDRAALLSGTDKIKFDKEYDLRLRQMAQDKRSAPTERTKTEDEKMEEEARKLQELEAKRLRRMQGAPESSDEEEEPAAAEEDEEEDDFGFGSGIKTRPTMAELGIDDEDDFIIDDDLVASGSELEPSDDEDSESENEADDGEDAEFLKGLLTEEEAKRPEFLTGANAPIQETPLPANNGVNGDLAYTFKCPESHEELLDVMKKVDILDFPLAIQRIRALYHPKLKSENKAKLGHFAVSLVDHISYLANQPKQSPFSILETIIRHIHSLAKTYPAEIANAFRRHLEEIHNSRALAPTPGDLVLLTAVGSIFPTSDHFHQVVTPAILTMTRYIGQKIPQELSDYAIGAYLSILCLQYQRLSKRYIPELVSFIQNTLCVLAPTKPTKISGDFPYHEPKTNIRIVGGTKATRKLSLSDCISTDRSEAQTEALKIAILDTTVQILDAAADTWTGKPAFVEVFEPTQKTLQHLATRNNRSKLHADVQAKITKVSQKLERLLKHAHLACRPLELHHHKPLAIKTSIPKFEDSYNPDKHYDPDRERAEASKLKAEHKRERKGAMRELRKDANFIARESLREKKERDAAYEKKYKRLVAEIQGEEGREAKEYEREKEWRKKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJG9</accession>
    <name>A0A3D8RJG9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_07562</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJG9"/>
    <dbReference type="OrthoDB" id="551633at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019186">
        <property type="entry name" value="Nucleolar_protein_12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14577:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09805">
        <property type="entry name" value="Nop25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="152"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="49"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="167"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="192"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW74120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="25969" checksum="F8EAE76A24497104" modified="2019-01-16" version="1">MDNQFIVRPRPKKSLRPPPSKKRRTNKSGIEEISFDFDARSEYLTGFHKRKVQRTKAAQEQAARLAREERITTRKQLREERKQELEEHVEAVNALLKDVDASKDYVESDEDGEWGGIQDEEPRPVIDHEEEYIDEDRYTTVTVEEVDVGKDGLHKIVAEDSSDETMDAERPKPESKDEMKKVWPKKPRKQKFRYESKTERRMSRAKQKAGNKAKANARKGND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RND1</accession>
    <name>A0A3D8RND1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major myo-inositol transporter iolT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_06374</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RND1"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF29">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="39"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW75553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="543" mass="61096" checksum="CDFBF0AA34CC14BA" modified="2019-01-16" version="1">MGIVTHVEGTSDPIVTRMVEEDKVAWYKKKNLRKLYLFLFPACMGIEMTSGFDSQLINSLQFIPPFNKYFGAGYINPATKSASIKPNILGLINAAYSLGAILAVPFAPAVNQWLGRRWTIMSGSVCMVIGALLQGFSVHIAMYIIARMLLGFGIVFCIISGSAMIGELSYPKERATMTSLFNSSYFIGAIIAAAIALRTADIGGNWSWRIPSLLQIFPSLFQITFVFFLPESPRYLISKDRDDEAFEILVKYHAEGDHDSVIARAEMAQIKTTIQIELEAAKLSWRDMFRTAGMRRRVFIVSFMGLFTQWSGNTLISYYLSTILGMIGYNTTYAKTRINLANQCWNFITGTLAALVVTRFKRRTMFLLCTTSMLTVFIGWTIAMQRVMLASDHGLKNGAASIAVLFFIFAYQPCYNIGNNALTYTYLVEIFPFAERTRGIAVEQFFGRGANFFSTYVNPIALTAITWKYLAVYCVWIAFEVTFVYLFYPETYGRTLEELAFLFEDKALTDNVVVAVEKQIHYGDKGPELDVAHVEEVRPQNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPD1</accession>
    <name>A0A3D8RPD1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_06748</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPD1"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="169"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW75927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="333" mass="37020" checksum="B4F9B9C6A9B8671B" modified="2019-01-16" version="1">MACVDSFLQFNDESFALKLQLEEIEAQRELQSGKWTENNPPDFALAFDDFEAELKKALCLVEDLKFAHSIAKAVDSDAVAIKESMVEEAQSVQDRGFAISLNEDENLPSPDDTNTIDMSRFEAESVDWDHVLRATEASTFSNKSCSTVAGPSTLYTLRQKAVLEHLPQLKVECSVCGKSVHPHFTVRLMCSDVYCKPCLKSYFLRVAKDESLFPPKCHRRLIDISNIKADFSTEELTIYRAAELEFSSMDRVYCAEPECAKFVPMPQRTPDCASCKACGAGTCIHCKALAHNGGCIADGTRQSLLDFADEQGWKPCVGCGEMVFRSEGCDHMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPD8</accession>
    <name>A0A3D8RPD8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_06758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPD8"/>
    <dbReference type="OrthoDB" id="3902588at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW75937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="594" mass="65561" checksum="A05234AFD443D729" modified="2019-01-16" version="1">MFDVSWTDPTSVTVGEHRRRKEREAGKSSQGSEGSRRSSLKSSSSGASSVTQSTSRSGWGLFGGSSSKKPSEKALGKFSARTKSSPASSGSNPPTGPPASLVLSAYNDPPVRQPQVEEGHERRRNTNIETHQLDHNRQSFAGPPSTPTDSVFSSPTYRSSQTDSSWGSISEVPSKAYSNVRGHTGLTSFYQDDNTLDQLMNNASISASDDDYSEAPDKVSQLSRVSNHAPRNTSLRGRPPPRLSSPPPNRSLPEPPRPENTAMRQRLRRMEAASPKIILERLREEWDDVTDDAIYNELEFEKSLWMLVGLRTLTRQASGETSSDGRFVEPTAEPTKYLSLYESQACASLLSTFPPTGSKTHHLSLNPISSLEQTSHLRTLIVTTPVSDLPYKPSSFKLINSLRLSVLLPSSSIPNLLQECHRILCPRGILNLTVMDPLPRSSTLGPKMKAWLDDHLILKLETQFRCLKPTRLMPIWLQDAGFLAAQSSKSAASEPSKTLKITEDMLQEPTTISFSFRAVARGEGGYGGEVAKGEKKNGERDALASTVGRMLWKEIYGPYVSGRTWWWEDEEIIEEVSQLGTRWDISIIEAIKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RQ60</accession>
    <name>A0A3D8RQ60_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_07010</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RQ60"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF6">
        <property type="entry name" value="TRANS-ENOYL REDUCTASE APDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="33"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW76189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="373" mass="39655" checksum="C7E2FC25CD4422E9" modified="2019-01-16" version="1">MSVSTTNCPIPVRTDLSQGAHKDIKTRRAVAAKQTGKYQLIETRLPEIGPGMVLVKTAAVALNPADAKTIDYSATVGAIGGIDFSGVVVSLGDGVKRLKIGDPVCGMVFGLNPSDSSIGAFSNYVGATEDLICRLPDSMSFEEGASLGAGVGTAGLALYQSLGLPMPDKPAVTPFYVLIYGGSTATGTLAIQLVKASGLIPLAVCSPYHFDLVKSLGAEEAFDYRSPTCGSDIRSYTSNKLAHALDCITDTKTMKICYDSIGTAGGKYTALDPYSTRIKYTRRNIKADWLMVYTLLGDPVRLAGVYARPANPGDRKFSSLWYPLAERLIAEGKLKHHPIEIKSGGLLGVMDGIDELRTGMVKGKKLVYLLDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RV41</accession>
    <name>A0A3D8RV41_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative efflux pump antibiotic resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_05700</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW77848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RV41"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF177">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="536"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="62"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW77848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="582" mass="62621" checksum="8DED6BE370AA0CE0" modified="2019-01-16" version="1">MVSSDLDPEWKRQKRQADESSEGLKPLGTEKADENVQDLNSVETPNEPPGTEYPHGMRLTLIMISLMLTVFLVSLDNTILATAIPKITDEFHGLDKVAWYSSAYFMTFGGFQSTWGKFYKYFPLKIYFMGAIAIFELGSLVCGVARGPTALIVGRAIAGVGGAGIGSGAFTIIGFIAEPQKRPALIGFTGAMYGMAAVLGPLLGGAFSDKVTWRWCFYINLPIGGLAFVIVLFFLRIPSEAKPIEATWKEKFLQMDFPGAAFAMSLIVSCILALEYGGQTKAWGSSVVIGLLVGSFAIFVTFVVWEIYQGERAMVVPRIFKQREVWVSCIFQFFFAGAYFVILFYLPIYFQGVFNVSPIGSGVRNLPFIILLTIAVILQGPVLTKVGYFTPIMAIGAALTAISCGLLYTLEVDTSVGKWVGYQIFCGFVIGMTFQTTITVVQSGSTPEDMSSSTAMIFCEFFPPQSTRNAEQLLTGAVFQMLGGAFLLSASQSAFNNRVIATLASTAPGVDPAIVLATGATQIRTAFTSVQVPGVVAAYMAGLKVVFAIAVGATSFAALFSLCGSWKKLHAKALKDTAGSAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RV70</accession>
    <name>A0A3D8RV70_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_05730</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW77878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RV70"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009403">
        <property type="term" value="P:toxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000047">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW77878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="503" mass="58112" checksum="EE3FB94A8A98D940" modified="2019-01-16" version="1">MEQSYRGSLARVVTICSAFAALYVTYCVGVVIYNIYFHPLSKYPGPRLRAGMHAVDLWHVWNGDQPVAVAALHEIYGDVVRTRPDTLSYRTAQAFKDIYGTRAGKHQLRKDPRSYTITGEEQTHIIYSNDADHSRMRKLLSHAFSDAALRQQEPIMHHYFELMVHKLEDRIDNAGGEVDISKWYNFLTFDIIGDMCFGEPFNALESGKYHYWMSNLFNGIKYSRILVIAAFYKPALPILMAIASLFPAISKAKEEHETFTRLKTEKRLEAKTDRIDFMTYILRHNDERGMSKEELMETSGLLIIGGSETTATLLSGATYYLLQTPRVYAKVKEEVRTAFKDAQDITLTSTARLPYLHAVIEEALRLYPPVPFALLRKTPPEGDMINGEFVPGDTCVGVNHYAAYHTADHFHEPKVFAPERWLPDRPEQYRNDRIDVLNPFSIGPRNCIGKNLAYNEMRSILARMLWHFEMELLPSSNDWQNHKSYFLWEKPDLYVRLSRRKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVM9</accession>
    <name>A0A3D8RVM9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_05776</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW77924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVM9"/>
    <dbReference type="OrthoDB" id="195446at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="2">
        <location>
            <begin position="175"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW77924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="590" mass="67149" checksum="56F078A14BC4EDD0" modified="2019-01-16" version="1">MSFGFGIGDFLTVIALATRIRKEFVGAPQECRAISDELKSLSVLLLDIEVDMTNSDMGTDQAERLKILVEGSQAVLRDLEAFSDKYIAMESNTNSRVDRAWKRFKFDTQEVDKLRARLISNVSMLRAFSERHIKEGLVQMVRHFDNQKRQQILDWVSKENHTAKQNHLLRHRLAGSRRWLLESLEWKEWVKSRGSTLYCPGIPGSGKTYTTAIVIEELQNMSQVNDGMAVAFVFCDYQRQEENVYELLARSLLRTLLEQLDMVPQSLNHLYDTCMRSGHDLNANEVYAHLKIVTSQIPWTTLVVDALDELEPESRDLLVTNLYKLQSEAKVNLFFTSRKVSTIQILFPRAGTVEVTATSDDVQNYLADHMKLLPGFVQRNKAIQDEIKDAIIIAADGMFLLAELYLEPLKDKKSPKAIRASLRSLFDRSASYEKAYRDAMVRIQAKGKDRFILAKTTFLILTQARRPLRAMELCHALGVEANEFDPEDVPDIEDVLSNCTGLVTYHVESDVVQLVHRSTKEYFEACRAEWFPDAAVVMRDICVAYKHARDAAADGKATEADFPFLDYVNKYTGSHQAQVVNENAEKALAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVT2</accession>
    <name>A0A3D8RVT2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF3602 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_05950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVT2"/>
    <dbReference type="OrthoDB" id="2537432at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053203">
        <property type="entry name" value="Cisplatin_resist-associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022024">
        <property type="entry name" value="DUF3602"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693:SF3">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34693">
        <property type="entry name" value="PROTEIN PAR32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12223">
        <property type="entry name" value="DUF3602"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW78098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="133" mass="13995" checksum="DD8C527E9758EF9A" modified="2019-01-16" version="1">MSARNSVEVSHGRGGAGNIREDATPYGDGEIVREGVVGDHHDGAFSTGRGGAANIGSPKIDATKRADHDSIPETALRPSMENENYHTGRGGEGNIHEADKPAEKPKHPVGLADKLKNKLFKSKASKEAKTTTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVZ7</accession>
    <name>A0A3D8RVZ7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GTP-binding nuclear protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_06027</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVZ7"/>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00877">
        <property type="entry name" value="Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000131">
        <property type="entry name" value="GTP-binding nuclear protein Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00627">
        <property type="entry name" value="GTPRANTC4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW78175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="217" mass="24212" checksum="EFDA425F6457D2EB" modified="2019-01-16" version="1">MAEGAAAVPTFKLVLVGDGGTGKTTFVKRHLTGEFEKKYIATLGVEVHPLGFSTNLGNIQFDVWDTAGQEKFGGLRDGYYINGQCGIIMFDVTSRITYKNVPNWHRDLVRVCENIPIVLTGNKVDVKERKVKAKTITFHRKKNLQYYDISAKSNYNFEKPFLWLARKLVGNPTLEFVAAPALAPPTAQVDEALLAQYQKEMQDAANMPLPDEDDADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RW77</accession>
    <name>A0A3D8RW77_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BP5796_06088</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RW77"/>
    <dbReference type="OrthoDB" id="26491at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09908">
        <property type="entry name" value="H3TH_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000011">
        <property type="entry name" value="exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000002">
        <property type="entry name" value="Exonuclease 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037315">
        <property type="entry name" value="EXO1_H3TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF65">
        <property type="entry name" value="DNA DAMAGE-INDUCIBLE PROTEIN DIN7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="16">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="15">
        <location>
            <begin position="156"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="362"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="413"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="562"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="625"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="458"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="563"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="580"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="625"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDW78236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="807" mass="90066" checksum="C79B389DDDE776CE" modified="2019-01-16" version="1">MGIQGLLPLLKSIHKPCNLRKFEGKTLGVDAYGWLHRGTVACAMDLAMGNPTRKSVQNSPAYMGRQELIVYRFIDFCMHRVRMLQHFGVTPFLIFDGDYLPSKAATEADRRKRREDSKRAGMELQRSGKVQQAYLEFQKSVDVSPFMARQLIDELKQAGVQYIVAPYEADAQMVYLERIGVIDGILSEDSDLLVFGAKCLLTKLDQYGECVEINKADFCACKEITLTGWSDVEFRRMAILSGCDYLASINNMGLKTAYRMVRKHKTIEKVIRMLQFDGKHHVPNGYLEAYYQAELTFLHQRVFCPKSETIVFHTEPDQQIDDEKMPFIGAYVEPEIARGVARGDLDPMTKLPIVIPTKNKMVTSSSPWTTPRPKPRQSMTSTDIKKGTPIDRYFKRTPLAELPLNVFSMSPSQEELLRRQPGDWTANPAPASLPRPSVRRSSSSPLVTSPQSAPPLLRTGTTRSRTSILPEPRPSKRARMCEGEQTLSPVTGKKIELVASPFFSKYEPSPTAGRVTKNRRSKKEDFHIFSDDSVEDAMLSLPDFDGFDNSMARPQKKIAIFNESKDQNVKDSLRDEAESKSTQQREPYLTPATSAASSAEQPSTSSDYDLPAPRLGLREKFSFSAGQSTPLSQRDSQLPLTPVSIPPQRRSRIPLAVKNGTAPPVASVSTMQAKLTPLQRLRTSATSRRHILMTPPSTPLHHVETPLPREITSLKDQSSEQKADVDPASIPLPTPDESENIALAVPASIPLPIADEAEIVALAMPNGSEDMIIHDSEADEDALLSEPETESRGNVKVVDFQRFAYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWA0</accession>
    <name>A0A3D8RWA0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_06062</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWA0"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW78210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="161" mass="17520" checksum="66472AB1BE0A1872" modified="2019-01-16" version="1">MCYTPRSSVPPIAFKDHNIVYTGGADYTLEQHVIMRSGHDIIVHRGRLIIPAFLNTNGGCIYIMRGEVVFHGAMNLGGGQVFVHGGATLRVGRGLSCRERRAGREPIRPKVIAEGNVVLQKGATLHVHDYLRIQGGEVKGNVLSHIITDVSAKIETPSSGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWJ8</accession>
    <name>A0A3D8RWJ8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_06247</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the glycosyl hydrolase 18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWJ8"/>
    <dbReference type="OrthoDB" id="3012298at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06546">
        <property type="entry name" value="GH18_CTS3_chitinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF60">
        <property type="entry name" value="III CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G03850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="6 8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="10">
        <location>
            <begin position="10"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW78395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="353" mass="39195" checksum="D665B5828E611D59" modified="2019-01-16" version="1">MPPIPSSASPRVIIYFQTLHSPDGDPISILPIITQPNITVTHVNLAAIHLNDPPGNITLNDHVPSHPRYMTLWAELRILQASGVKVLGMLGGAAKGSFTRLDLDDATFERYYIPLRDLIRERGLDGLDLDVEEPMTLAGVIRLIDRLKADFGKDFIITLAPVAAALVSDKPEHNLSGFSYEALEVMRNKSIAWYNCQFYCGWGDVSNTMGYDFMVARGWSPEKLVVGMVTNPSNGSGWVPFETVQEVLLNLRLKYPKFGGVMGWEYFNSLPGDRERPWEWAAFMTKHMRPSLQPPETKEGLQPSAQSQRLAAIDSLAHVKPNPVLVDEDTGVKGADAPIPSEFEYFTDGSVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RX33</accession>
    <name>A0A3D8RX33_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">p-loop containing nucleoside triphosphate hydrolase-25</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_06246</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RX33"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="508"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW78394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="706" mass="79662" checksum="9027AECF39652129" modified="2019-01-16" version="1">MVAVDNNMPVPQEADAVALEESKVVIAHLMAKLGSATQQAAAGTADKETKETEETEEADETEETKDVTPAQAKQGMQCEVKNLYQKEDERGRCTWTEKYPDGLEEAAENEITARYAILVRNKKSFDSRKKLEIDSVVVQSPLLKEILGKVLKDYPGVSTNLNRLVFSAPFHAFVHRWEQFTTAKDAQEDGEAKEHLQLLYNVLHDELKDIIAARNDYTAKGIITFEHLWTIYQPGCTLFTSEWGRECAVKFIRGNYYEHNKYGPVFGMNTQVLDWDGDKFGFASSQSLVLAYTGTMAIADLDAFPLKFHPNENAIRAKLLKRGKLFEGFHGYHYKAYKAFALGKDFCGNTIKVTVDSRIIIDTYAFGKFNPNRLPHLAPLKSKSNNTPELSDETEDDETYESEYYDSDDDDSEGYGSDNDLDTGKTRKRMPLSHDQLIYASPRLKGYALKTKQWLEFFVDSVSDIQWNNEAFESLVLPADQKELILAFASSQVKHKDTFDDVISGKGKGIILLLSGGPGIGKTLTAESVAEDMKVPLYMMSAGDLGISSNEVESSLTQILEMVAKWNAVLLLDECDVFLEARSAHDLERNKIVSIFLRTLEYYEGILFLTTNRVKNMDPAFQSRIHISMEYPNLDAAARSQVWKNFLDRGVRHELGEEEIATLAKVEINGRQIKNILKTSQLLARHKDMPLRFEHLKTVLGVEGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2I7</accession>
    <name>A0A3D8S2I7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative TPR repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_05215</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2I7"/>
    <dbReference type="OrthoDB" id="1936594at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044244">
        <property type="entry name" value="TTC27/Emw1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="613"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="647"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="295"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW80517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="965" mass="108052" checksum="E5D26AB237C94B9D" modified="2019-01-16" version="1">MAASTLENQSWDALICQLEALKEIPELSDIVSSYLNGDYKVILKNATSQKLFQKLAQFVDLSAEQQPSAFTDGDFASNDVESMQVIITGLAAFDAFLQANVTGPPLVLTNIFTPDGDVASFTGKCLRSLDLDGVSVYQYIPHVEVFCLARMVFANYFPRLVGGNFRDCKWMRVRINAYHQRLLSGMAGGKLSDSVFLQNQIEKDLKNLDLEIMSSESSFSTEAKVQYHLEKAQIYIMQGLDFKAKENVQMAKTVSGFNYALTGALGKRTKFQQNDLSQLVVVAKSKEEDAVIGESSNLTALKESLPPTSEQDKKDGTAPTALDLNDDTLFESIQFAKTSSEKVEQSSLPTELAEMTPDNQPQLKPLDQITLLTEATLKDTYSPLDNLNSEEILPYAVRVLSDKPTNWQIYTQALLVRSRIESHRSRTQERSVLQLQAIVDQIIADTENEETAAANADGIPQIQVTSFLPRAKADESAPVTERLRYIYPLHSPTRWEIETELAFAWSSAGSLVSALEIFKRLRLWAEVALCYFSVNQEEKARQIVRRQLYHSSKGPEMDKYGIDDEEVVKEQWDGEMRTPPPPHSPRLWCILGDLEQDPECWKRSWEISKNRYPRAQRTLGEYYTKQGDLESARDAYMKATVVNRQNDDSWNRLGDIDLRVGNWDGAIVAFQQSIMIDETDAKTYNNLGSALLSKHAELIHLQKANAQDIKASDEIDDDDDEEVALQVSQPSPKDVLRQALSAFKRGATLAHDNWKIWDNVITIAGRMSPPSFPEILLGLRAVLRIRGPSIGEEAVDIDVLRALITEVITRDRDGGEMVAGIWVPPRGSLARATIELVDAEIVPLITKRAELWALVEKLAMYRRDYAGALACAEKSWRMATQSEGEKWLEDVEAWKGVATATDGLMSALENYGPMEREDGTEVEKGWKTKARSAVRGILGKAKGAWEDTEEYEMLKGRLDELKAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2L9</accession>
    <name>A0A3D8S2L9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ASTRA-associated protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_05227</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Component of the ASTRA complex involved in chromatin remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the ASTRA chromatin remodeling machinery complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat ASA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2L9"/>
    <dbReference type="OrthoDB" id="7668193at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="54"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="430"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00037338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00040563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW80529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="445" mass="48886" checksum="706FA83BF626B113" modified="2019-01-16" version="1">MPRLVSPSSKRLPHRLQTGKPSSPENLDARPDNVLNKATNGWMALPPAQPSYILRGHASQIHCACFIRSNKRLVSGDADGWIVIWSLDIKRPLAVWRAHEGAILGADTWGPDKLITHGKDNKLVVWRLSSEDESSLSTVLPVDTPPEPRRQPWVLHILNVNTMNFCSFACGPAYPAPTAPPDTSDELLIAVPNTLSSETVDIFHLPTGKRIHTVPSAPGLKGGMVMAVSIFHHPQTKNLIVVAGYESGHTAISQFTMRPKSWDSRESTYTARTSAEEQKSWQTSYLSQPHTQPLLSLSTSPDFTYYLTSSADSVIAKHLIPSTIPTQLALTPSQPHKINQTKHAGQQSLRIRNDGKIFATAGWDARVRVYGCKTLKEVAVLKWHQEGCFAVAFADVDVDVGGGDKGDSGAGKLISVKEERVRRAEKAHWIAVGSKDGKISLWEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2S6</accession>
    <name>A0A3D8S2S6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATP synthase F0</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_05266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2S6"/>
    <dbReference type="OrthoDB" id="3342455at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013920">
        <property type="entry name" value="DUF1774_fun"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992:SF1">
        <property type="entry name" value="DUF1774-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37992">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08611">
        <property type="entry name" value="DUF1774"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW80568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="316" mass="36049" checksum="DC0C2E721309FB6C" modified="2019-01-16" version="1">MANFDQGTFYSFKLHRSFTADLEFTADFLLPVNPFSRRESHSAASVNTYKVLTILSWLLVVITSFYYSFNVPQDDIKKWRSTIWGVNAVYHTPFATSSVIASIYWIILFISQVGYVWHLFSGNSEYVNAAAGVGSHFILNNLLQFAWVMLFVRGHFIWSEILVIVNFFNLSLLYFRHNTHPRFIHFPVISGPLAWSFFALYWNGAIGVNAHSLPARILANVAIWGILVYGLFFLVTFKDYTMGFALSVLTASLGVHQFLQKAFALQWIFAFAIMGTLFLATLVIAVPGIFGKEFKFGREHHIVEPDQERAPLLEDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3F0</accession>
    <name>A0A3D8S3F0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_05319</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3F0"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW80621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="67" mass="7498" checksum="26FC7005C9E67B5B" modified="2019-01-16" version="1">MGSVHGCQKGESEKGDKAMYKLAMLSDLSLHYCPGFDTSELITKQLETYDKSSNENEDLILKPDVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3G8</accession>
    <name>A0A3D8S3G8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_05312</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3G8"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW80614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="121" mass="12417" checksum="26E44598E6D53F2A" modified="2019-01-16" version="1">MHFSASPLSGPDASYSLGSEHFPARACQPQTAGAAGYGGRMGVQRPGAPAPAEPQTVDPCAAPVQLSPAWHPQPPSPIASSADLVHRPLGMAMGIHIPLPAVWSTVYVLDPSADGYGPAKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3H6</accession>
    <name>A0A3D8S3H6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA polymerase delta subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_05526</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3H6"/>
    <dbReference type="OrthoDB" id="514823at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904161">
        <property type="term" value="P:DNA synthesis involved in UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1030.20">
        <property type="entry name" value="DNA polymerase delta, p66 (Cdc27) subunit, wHTH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019038">
        <property type="entry name" value="POLD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041913">
        <property type="entry name" value="POLD3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17598:SF13">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09507">
        <property type="entry name" value="CDC27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="197"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW80828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="416" mass="45640" checksum="4465B5B05795E1C0" modified="2019-01-16" version="1">MLFEFHRQQNGKKPGTIYATYLVGGIKRADEKAVIGSAKKDGEDEYMQSSPFMSSSMPQPDDVVRATSTFTVSLTGEENLDNLYSQYESITSVHVYSIGPQPIKDLQILADATREVQQVEIGNDPLASLSSYGTIINKDVRRRTGKPKLQQVPAAIPVKSAPATSKLSAATSNPVPETKPQISSAAKDFFAKGPAKVESTVKSETTEPKPPPTLKKESSSIFKSFAKAKPKLKREETDSSAAQSPRESAPASGVEDEPMRDVSEDEEETWVPPPKTNSNDIVDKDRKSRKEREAKLKQMMEEDDADDMVDTPTTKVEEDDDKETEQTEANPEATTEAPPVSGDRRRGRRRVIKKKTIKDDEGYLVTKEEAVWESFSEDEAVALKTKGSNAASTALKPKKVAAKTGQGSIMSFFGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3I8</accession>
    <name>A0A3D8S3I8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPN-loop GTPase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_05332</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3I8"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17871">
        <property type="entry name" value="GPN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000338">
        <property type="entry name" value="GPN-loop GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030231">
        <property type="entry name" value="Gpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF3">
        <property type="entry name" value="GPN-LOOP GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="300"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="300"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW80634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="346" mass="38976" checksum="FB0947D4FA96EBEC" modified="2019-01-16" version="1">MPFAQLVVGSPGAGKSTYCNGMQQFMSAIGRKCSVVNLDPANDQTSYPCAVDVRDLIKLEDIMEEDDLGPNGGVLYALEELEHNMEWLEQGLSELGEDYVLFDCPGQVELYTHHSSLRNIFFKLQKLGYRLVVLHLSDSYCLTLPSLYISNLILSLRAMLQMDLPHLNVLTKIDKLSNYSPLPFNLDFYTEVQDLSYLLPHLEEESSVMRGSKFEGLNTAIVELVESFGLVGFETLAVEDKRSMMHLLQVIDRAGGYAFGGAEGANDTVWQVAMREGVTTMDVKDVQERWLDAKDEFDEKDRREWEEQAKQLQAKAAEAQEEDEDDFENMPLPPGGSGIKIVRKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3M2</accession>
    <name>A0A3D8S3M2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_05573</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3M2"/>
    <dbReference type="OrthoDB" id="431626at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000373">
        <property type="entry name" value="Importin beta-5 subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056840">
        <property type="entry name" value="HEAT_IPO9_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF9">
        <property type="entry name" value="IMPORTIN-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25018">
        <property type="entry name" value="HEAT_IPO9_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="5">
        <location>
            <begin position="27"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW80875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1041" mass="114158" checksum="1EE6A6C1D3A9FC39" modified="2019-01-16" version="1">MAGTMEDQLLQLLADTQLPAEGPRKQAELHLRQATSQPAFPTSLAAIGSHGSVSPEIRQSALLLLRTYIEKNWSGVDEDGNGAIQIQDATKEQLRVQLLELATSNDDNKKVKSAASYCVSKIAGVDFPERWPALLPALLHLIPTASDSQLHGALKVLSDLVEDCLSEEQFFSVARDIVNVVYGVAIKEERKPVLRALAVSVFKGCFDIMDMVKDEHGPEVKGFADEALSAWSPFFLEIMKKQLPPRPIGSNEGHESESKEQAATWRGVIALKLQVVKTLMKIRSVFPQLLLPQTPVLFQATWEELSILQDAYKDMYVENDEQGRLEDSDGLPYTLDFLVLEELDFLQSCLRAPPVQKELESQLQAHGGVQLTPWVMDVMKLAVGYSQIPKEEEDLWDIDVNLFLAEETSVTANYTARTACGDLLIKMGEWIHQAALEGLLIYTKVLFATEGTTWRLREGSLYLLTQLMTDFLDVEKPVAPEVLSQYLELIEYAINRPDEPLLRARGYLVAGILVQSLPNLGTGLLDRTIEAVNKDETEVVKVACIKAIQGFIRASAVPADRQVPIVTSISEYLYGKDLTDLEDSDDLLVTLVESLRAAMSIDPRICVADGGALDLLFVIAKNGAANFQLTMLVNETFEEIVASLSGGDAYAALCGKVLPSLTGAFDVANVTGDDPLVTLATELLAVLTENGSEPLPPGYVAAALPKLNRLLMVTTEGEVLRPGVEAIKFMLMHDHQQVFAWQDESGRSGLEVCLIIIDRLLGPTMEDNAASEVGGLAAELVEKAGQERLGPYLEQLLKAVATRLSTAEAAPFIQSLILVFARLSLVGAQDVVNFLAQIEINGQVGLQVVLSKWLENSVNFAGYDEIRQNVIALSKLYGLNDQRLAATMVKGDLIIPTSNRIMTRSQARKNPDQYTLIPAPLKIVKVLIEELLSASGHQNGAIASATADFDDDEDADDSWEDVPSSVLDLGLGSTKAELMAWGQPGDGQGSFFMRQRDDETQAYLTEFFVRAAREDLSGFNVLYGQLTEDEKKKLNELATQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SA70</accession>
    <name>A0A3D8SA70_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SA70"/>
    <dbReference type="OrthoDB" id="10258156at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052220">
        <property type="entry name" value="METTL25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496">
        <property type="entry name" value="CGI-41 METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12496:SF0">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13679">
        <property type="entry name" value="Methyltransf_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="132"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW83004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="590" mass="66491" checksum="E11B126CAFB29BCC" modified="2019-01-16" version="1">MPPPEALPISPEFSSVDEYVDSLLHFATASTIFQTLCGGVHILDFFTQEPSLYHKVIPEEWRVWLLRQDSMELLNFFMRDNLDTAREDAPPESLLRYVREIRKHSLQRQSRREPAEKKTKLPRHIAVGMVPKKIHEVSNFADYVVDVADSTGTGITHFVDFGSGQNYLGRTLASPPYNKHIVAVESKEGNIKGAKGMDVHAGIAEREKVMRNKKLFRQQQDNVKPEAEWSEKDFRRRAKKQEIVEDNGADLRPTKELDTIYTSAEGKGYVQYVEHIVKDGDLSNVVAQIQTMDTALPVGNTEDPSGRPIALEITPPKDVRLMAISIHSCGNLSHHGIRSLVLNPSVHAVAIVGCCYNLLTERLSPPSYKLPLMRPNLRPINAPPTAYIEEHDPHGFPMSERVGTCDRGDGIGLNITARMMAVQAPWNWTPKDSDSFFTRHYWRALLQKMFLDYGVVGIAKSTEFPDSTEPVIIGSLRRSCYASFTTYVRGALAKLAADPERNMNALIDEKMGGMTDKDIERYAAEYDAKKKELSVTWSLMAFSAGAVESLIVVDRWLWLKEQPEVKDAWVEAVWDYGLSPRNLVVVGIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAH1</accession>
    <name>A0A3D8SAH1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_04816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAH1"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="184"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW83325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="705" mass="76850" checksum="5DDBFF097F7A3CA0" modified="2019-01-16" version="1">MADSIQQIDSDVLAGPVSPTSPTGSAASTREHAAAIAIGAPRLKGRAKLLQGLHRISSSPSLAQIGRKRASSSPYGSRNTISCVSLAPGGSPPNDDGSYSSQSSAGGYSTAPTTPGLDTPCLDGRFPIRKVEFGTPGCSTPTSPMPLGSPLSKVLSPFPELVEDYFSIPIDEVKRTKRRNFDFWGEMPHEIKLSIFAYLKPKELVRASNASKDFHRTCFDGQLWTCFDASEFYRDIPAESLSKIIVAAGPFIKDLNLRGCVQVEHYKRAEVVVKACRNLINATLEGCKNFQRSTLHSLLKSNERLAHLNLTGLTAVTNGTCKIIAQSCPQLEMFNVSWCTHMDVRGIKAVLLGCTRLKDLRAGEVRGFNNLEAAQTIFETNSLERLVLSGCSDITDEALRTMIMGQDPEIDILTNIPCVPARKLRHLDLSRCTRLTSNGVKSLAHLVPFLQGFQLSGCTLLDDSALSPVLATTPYLTHLDVEELSLLTNTLLSVDLAKAPCADKLQHLSISYCENLGDTGMLPVIRSCTALQSIDMDNTRISDLVLVEAASMVRARSSTASNQKSRPKLGLRMVVFDCQNVTWTGVREVLSRNGEVSKPACSSSSPYPTEIIQLKCFYGWMPTVNEHLKRVLRGDLPAAGRLERKWVEYMMANEEAGAAGAGVRRRRRRAREARMMHADEEEGGFGMGGGIGRRRRARSGGCAIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SBR9</accession>
    <name>A0A3D8SBR9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04689</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SBR9"/>
    <dbReference type="OrthoDB" id="5582162at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022057">
        <property type="entry name" value="Chs7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35329:SF1">
        <property type="entry name" value="CHITIN SYNTHASE EXPORT CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12271">
        <property type="entry name" value="Chs7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW83198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="240" mass="26648" checksum="2CF12CC197EE0088" modified="2019-01-16" version="1">MPKADDTILVSIFLLWRSEQKQAAVGRREMQLFLVGYIIIEICEIFTVGEFPLSAKVRIAFSGIHLGMIVATLWILMLNAFVGYQIVEDGTPLSLGLILASAAVLFIGTGYIALDTGYGWTGHFASSYTPPNRNIGLYVLYQLAPLVFLFVFFALETVLVIRVLGERKPMIYLAAAALLFAIGQIFNYVISIHICNGTNGKIDGALFETLFTLLSVVMVWTFWSSITEDDWPMPVSNTYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SGS4</accession>
    <name>A0A3D8SGS4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative low affinity iron protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03818</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SGS4"/>
    <dbReference type="OrthoDB" id="2224262at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007251">
        <property type="entry name" value="Iron_permease_Fet4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04120">
        <property type="entry name" value="Iron_permease"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="349"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="457"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW85493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="541" mass="60913" checksum="6CDEDC7F674677C0" modified="2019-01-16" version="1">MSMWRKFKNSLSPVREPIAAHAPTQRALRRTPTRRMQAGAGKVAGRLSFLPFSRAVVESEKGEPPVLVRELPPLERRPTNSSLMYTNEQRAPAPKLGLFDKVTRAAGSNYVFVGMLVIVAAWVVFGFVKGTTDTWQILMQNASSIQVYVTDILLLRQQSNGMKSLLTTLAEMQSRNQSVDRLIRRIPDCEWMETHKSPAKRLLSGSGRPVEEEQEETLLIEIHQMSRMKYVWNRTCHAVAVGLGSLWAFAFYWVGIFFWVGIGPLFQFSDTWQLYVNTATAVALTFTSVFLQNIQQQQEDNLEKSLEYATKIDAEVEEHLRELAEDFKPNPIFEIPPPTATRSERFIDYFADIMGSGIGVSLSLVVVGIWLSVGHLLEFDDNWWLIIGTFTGLVGFIDGFILRNVYAREEVRVNQEFRNIAAEDSKIFDLLNLPQPDPPLEPPSTISTRISRAAGDLSGLAATSIGSVVLVFILIGIASIMKWSETGQLLCNTPTMIIEGFLLLILIQAHNVANEERGREFSGILKRRLLLNHYVLSLQQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SGS5</accession>
    <name>A0A3D8SGS5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CBM-cenC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03855</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3565312at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="506"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="305"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="506"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="546"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="570"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="590"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="608"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="652"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="683"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="758"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="793"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="807"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="841"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="917"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1044"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1059"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1079"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1106"/>
            <end position="1164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW85530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1342" mass="131843" checksum="1D93C8FD3B8566B3" modified="2019-01-16" version="1">MSTFSGLSSASAQPSSMTSKQTSTRPLTTSSSIRTSSTKSIVRETQKRPQSSSSTARTSSLTTQSQASPRSSQIASSVSLTPPQLSSSGTRTGSLPTQSQTGSSISSKLSQLSSSGTRTGSLPTQFQTGSSVSPILSQLSSSGTRTGSLPTQSQTGSSISSILSQISSSSIGTSSLPLQSQVSSRLSQTASSVLSTLSQLSLDASTGPLPTQSQTGASVSSLLSQLSSASIGISSLPLQSQASSRLSQPASSVSLSTSGLQATSLSTGSQFSSGAPSKSTTAAASSLSLISISSSAALSSSLQASPSLTQSPTSSSFTISPEDASGASTSRFSFSRPGTSQTSAAPSGASTIPSSIGASTLSSGLPSTSGTSIISMQGTSQSSSLDTKAPSRISTSETSILTSTASGLSSIVTPTLSRSSILGSSSSVSSAGGRVGPLAGVRPGVVTVSRASTSPTMILPTTTSSSGPSNLVSSLSSVPVLSQPSSSIPITATSNLLSPGTTLISTPSNSPLATPSTPLSSISSIRQSSTPGTGLSSATIPGQSNTPGTPSPGLSTTPGTPLSSLPIPGQSTTPGTPSSRLSNTPGTPNPGQSTTSGTPLSSTPVPGQSTTLGIPTSSTPIPGQSNTPGVPSPGLSTTPGTRPASTPVPGQSTTPGTASPGQSSTPGTPSLGLSHTPGTPNIGQSTTPGTPTPGQATTPGTQSPGLLTTPGTRPTSTPVPGQSITPGTPSLGQSTTLGTQLSSAPIPGQSTTPGTKLSSTPIPGQSTTPGIPTSSTPIPGQSNTPGVPSPGLSTTPSTRPASTPVPEQSTKPGTTSLGLPTSPGTPNPGHATTPGTPVPGLSTTPGTRPASSSIPGQPSTSGVPTPRLSTTPGTRPASTPNPGQSTTPGTPSLGLSTSPGTPNPGHATTPGTPVPGLSTTPGTRPASNSIAGKPTTQGTPLSSTPIPGQPSTSAVPTPRLSTTPGTRLSSTPNPGQSTTPGAPNPGQSSTPGPRLSSASIPRQSTTSGTPSPRQSTTPGTQLSSTPVPGQSTTSGIRLTSSQNPGQSTTPGTPSPRQSITPSTQLSSTPTRGQSTIPGTTLSSVPSASRSTTSGAALTSTPGTAKLSTSSRSSLLPPGSSPSLQASPSAISTSSAHSASATSSTLSGASRPLSGSTVSSHSTSAQPATSVSSFLTTFKSSTTSSPSATPTCVDKLVVNGGFETGALYPWSQPVTLEVSSFFGPVNSPELCRTGQSCLGNGLYDGSNIMFKQTIQLCSNDNFKASAWARADTGDSVCYFEVCIQNPRHCSGPIIVDTIWTEASFTFSGAPFSPKADLEVYTGCIGDSSTSFEVFIDDIGVQQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SGY7</accession>
    <name>A0A3D8SGY7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Fumarylacetoacetase</fullName>
            <ecNumber evidence="3 13">3.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Fumarylacetoacetate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BP5796_03942</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10244"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="3.7.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="3 13"/>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SGY7"/>
    <dbReference type="OrthoDB" id="9971669at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902000">
        <property type="term" value="P:homogentisate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="entry name" value="Fumarylacetoacetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01266">
        <property type="entry name" value="fum_ac_acetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069:SF5">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="Fumarylacetoacetate hydrolase, FAH, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Fumarylacetoacetase N-terminal" evidence="15">
        <location>
            <begin position="10"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="14">
        <location>
            <begin position="117"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDW85617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="406" mass="44111" checksum="D7D21E3F831EE647" modified="2019-01-16" version="1">MYADHFSIDNIPFGIGSSEFHSRETVVTRLEDTVFFLDELAEAGVFKILKDETVKTFSEPTVNNFAALQKSEQLATRKAIQALFANGLESLRSLPPQSYSSIAETRLYLPLAIGDFTDFSCSRDHVLNASEAVFKKRELPPGFEYFPVGYTARTSSIVISGTKIKRPKGQYRDGEKVVFGPTRRLDYELEVACVIGKGNKLGDSIRVEDADEHIFGLVLLNDWSARDIQGLEMNPLGPLNGKSFSTSISPWIITLEALAPFKAQAPKKNPDIEVASYLQDSDSRSSYSIDLSASIESKVSTDTICTTNFDTLYWTLRDLVAHQTVNGCNLNTGDLLATGTVSGTTAESHGCLMEMAASGGVQVSSGKGESLKKMWLEDGDIVRLVGKAGPGVGFGDCKGEIVAAQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SH09</accession>
    <name>A0A3D8SH09_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">HAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BP5796_03786</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SH09"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000068">
        <property type="entry name" value="Copper resistance-associated P-type ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000043">
        <property type="entry name" value="Copper-transporting ATPase 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00003">
        <property type="entry name" value="copper ion binding protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF32">
        <property type="entry name" value="COPPER RESISTANCE P-TYPE ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0186">Copper</keyword>
    <keyword evidence="13" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="453"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="500"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="583"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="745"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="785"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1134"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1167"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="17">
        <location>
            <begin position="15"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="17">
        <location>
            <begin position="190"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="17">
        <location>
            <begin position="273"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="146"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDW85461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1202" mass="130001" checksum="22E93BC8665D23B1" modified="2019-01-16" version="1">MTSPSSQPETSAKMVSTSYLLSNMHCPSCVSHIQNILYSLDPKPASVSPSLVSHWVTVEHPETLLPRQMSDALEDAGFDVCNVSSNDGSSDDTLVDLPLRQDGENGYLDQALRRWRSRSSANSRRERQSHKHVENCKQCRLAIEEEQEASTPPPKPILTQQQSQSSSETDDNGKKLPLVVVDTGSSQDIWRASLAIGGMTCASCAGAITKELQKKDWVQNVVVNLIANSATVDFRGKGHEKDIAETIEDIGYDAALDSVVDLKEPTKAPRDTWRASLAIGGMTCASCSGAITKELQKKDWVQKVVVNLIANSATVDFYGKEHKQDIVDAIEDIGYDATLDTVVELKESTGGRGPRITKRTVDIRVDGMFCEHCPPRVIAALESFGDRIQLEKSLTTHDPIVRLSYTPEVPKFTIRHIMSAISAADESLQPSIYHPPTLEERSRQIHQREQQRLLIRVILTFIIAIPTLIIGIVFMSLVSAQNPGRKYLDAPLRAGVSRSQWALFILATPVYFLCADVFHKRAIKEMRSLWRRGNPTPIIQRFYRFGSMNSLMSLGTTIAYVSSVAQLIAAGVHPSEMADNNSFYFDSVVFLTFFLLIGRLIEAYSKSKTGDAVAMLGKLRPTTALLLILEGQAGDARQAESLETVEVDLLEFGDTVKVLHGGSPPCDGTVVQGETKFDESSLTGESRPVKKSVGDQVFSGTVNEGSPVSIEITGVAGSSMLDQIVKAVREGQTRRAPMERIADTLTSYFVPMIVLIAIFTWIIWLSLGISGALPQSYMGTASGGWVAWALQFSIAVFVVACPCGLALAAPTALFVGGGLAAKHGILVKGGGEAFERASKLDCIVFDKTGTLTMGGEPVVTDFEFPQEIDTKSMPDEKTILAFVSALEGNSSHTVAKAIVSFCKDRELRSIDFDQVDEIPGKGMKASYTQEKTEEFVEVIVGNEALMSESLVSISDHTQGVLDSWKTEGKSVVLAAMKVASGEKWHLCATFAISDPIRPEAPGIVSALQARGTQVWMLSGDNQLTASAIGALVGIPATNIIAGVLPSQKAEKIQYLQKSLKSGSSSTQRALVAMVGDGINDSPALTTADVGIAIGSGSDIAISSASFVLITSNLNCLITLLDLSRFVFRRIKFNFGWALIYNMIALPVAAGVLYPVVSNGKHVRLDPVWASLAMALSSISVVCSSLALRSKLPGIGFRAKKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SH78</accession>
    <name>A0A3D8SH78_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cyclin-dependent kinase 1</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BP5796_03829</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Plays a key role in the control of the eukaryotic cell cycle. Required for entry into S-phase and mitosis. Acts as a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II. May function in concert with npp-16 to arrest prophase blastomeres in response to anoxia.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Forms a stable but non-covalent complex with a regulatory subunit and with a cyclin. Interacts with cks-1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SH78"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07835">
        <property type="entry name" value="STKc_CDK1_CdkB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000706">
        <property type="entry name" value="Cyclin-dependent kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000027">
        <property type="entry name" value="Putative Cyclin-dependent kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF254">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="4"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00054104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00065691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDW85504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="332" mass="37459" checksum="A5B9147FA3487F98" modified="2019-01-16" version="1">MENYQKLEKIGEGTYGVVYKARDLLHSGRIVALKKIRLEAEDEGVPSTAIREISLLKEMNDPNIVRLFNIVHADGHKLYLVFEFLDLDLKKYMEALPVSDGGRGKALPEGSGPDLGRLGLGDAMVKKFMSQLCEGVRYCHSHRVLHRDLKPQNLLIDREGNLKLADFGLARGFGVPLRTYTHEVVTLWYRSPEILLGGRQYSTGVDMWSVGCIFAEMCTRKPLFPGDSEIDEIFKIFRLLGTPTEAEWPGVMDKTCFPDFKSSFPKWQRDMSQPLCTNLDEHGLELLEMMLVYDPAGRISAKQACMHPYFEEGSAAYSGRGLGPTYKTNGYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHC2</accession>
    <name>A0A3D8SHC2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial carrier protein pet8 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHC2"/>
    <dbReference type="OrthoDB" id="529205at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW85747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="120" mass="13472" checksum="8718E0A937CEC852" modified="2019-01-16" version="1">MSFLLRTSTSRFAAARPAFRAARPFSTSRALALKESDRAQKLNFPALGIQDHPEQSLKNETHKEDSLKKQKSGKGHWKPELASDSEEAVTADRHEHADHSEAGIKELQKKTEKAAEEKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHT1</accession>
    <name>A0A3D8SHT1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_04224</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHT1"/>
    <dbReference type="OrthoDB" id="24948at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08366">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016901">
        <property type="entry name" value="APC10/Doc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03256">
        <property type="entry name" value="ANAPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51284">
        <property type="entry name" value="DOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DOC" evidence="7">
        <location>
            <begin position="93"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="48"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW85899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="304" mass="33984" checksum="237D5C73A43A2CE5" modified="2019-01-16" version="1">MTPSPLPPSPRTARRLYENARRARHRGQYDSSSSRNITPVSAPVNGSDDTDEEVEEDDDLADGDDEDDLDGGEEEEEEGADVEDIDDEQGEEEGGIEEVPMEIDPPFDPTALGLKEIGNLASWTVSSCKPGCGVEALRDDNTDLFWQSDGPQPHHLNIHFSRLVSIVSIRIFLDFEADESYTPTRITLLAGTGYHDLLPFSVLEFSQPKGWIDVPLDHVGGGEDGNTLRAFLVQVKVVENHQNGKDTHVRGLKVYAKDEKLGRNGFITTKSYDMDEPPEFPRKPRAVERDWLIEPDWMGEPELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SJ76</accession>
    <name>A0A3D8SJ76_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SJ76"/>
    <dbReference type="OrthoDB" id="10486338at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW85838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="213" mass="24087" checksum="E605302EBDB7BCBE" modified="2019-01-16" version="1">MSHRFETRPRSGGRIDTAEQSHEFGSQGLRDLPARLEEQAQLLRWNGKLQRRLRRLERAVQQGKRIEQTTTKGDNLPPPHLSPELKQGDSSNDNSSSTLSLRREILNQERNEADRQAAARTCSNTDSYHQLDRLILDFIAFHGSDNGLPVEPHPLTDINGVLSSKEDQQHSIGQVLLDILQVVGESLELPEQVAVLYQVFLLLRVSSLLFKNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SJH7</accession>
    <name>A0A3D8SJH7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_04253</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SJH7"/>
    <dbReference type="OrthoDB" id="4216928at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="3"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW85928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="412" mass="46582" checksum="00132F90E89A054F" modified="2019-01-16" version="1">MAKRRCGKQTPHCLRCRTRGIQCSYPPPKPARFVLCRNDDGPPVEPDVTPPINLQLCAYSPGLQASTAENARPSFVLDLPGHSSRPVDEQLASSWFSSLETWEIVRPSASQKLLTIPEMRAYLRKIHRWMSDWVEKGSNPFIHARLYGNRFPRCIQDAYASLSCYLHKTPANEQAVFHIIEDRAKQLLADNGVHSAGSPRESKNGRLSPVDLLEHVARVQALLIYQTMGLYDGNIRLRSLSETYIPVLEGWMLEMVQHAKHTVCLGESVISPVTEQTAVGPSRFFSTLDEDLLWYSWIAAESMRRTWVIGSSIQVMFLALHQGGIPPCQGGMMFTTRQGVWEAQSAVLWEKLCSEVHVGLMQMADIHRLFTEAAPEDVNDFTKVILEVIHGTDRIKRWGVQIDFFDEPCLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMH6</accession>
    <name>A0A3D8SMH6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_03243</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="289913at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059070">
        <property type="entry name" value="TPR_VPS8_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025941">
        <property type="entry name" value="Vps8_central_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 8 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23410">
        <property type="entry name" value="Beta-prop_VPS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12816">
        <property type="entry name" value="TPR_Vps8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25066">
        <property type="entry name" value="TPR_VPS8_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vacuolar protein sorting-associated protein 8 central" evidence="2">
        <location>
            <begin position="724"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="domain" description="VPS8-like TPR-like repeats" evidence="3">
        <location>
            <begin position="1269"/>
            <end position="1442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1481"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="148"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1481"/>
            <end position="1509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW87549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1588" mass="175234" checksum="8ECFAB334AAB3855" modified="2019-01-16" version="1">MSSSSAENDSGGEDDGTSTIKGSEDGYTTADNGLEEDTRPQGGRIVALLQEERDGAFTPPQVGNGTLASRYRQVQLDDTSEDGSLEAPPRRVGSPIDSILSTPDDSPSVQGSVLSSPGGSSILPSVASRPGLESPTPSFRPFDRRFQSRLSSSSLNTPRSASPAFLKGHSRQTSLSSQMLLETGDGDTGTPSPPWEVVRWTKLRKMNGQAFSEVGKRNFGVPTCISVSASIVLGTSKGIILIFDYHQNLKSIIGPGTKAIESGAITSVAISADHLVVAGGHANGSIFTWEAAKAARPFLHIPSLDASQLQNRTVDGHIPNVAVRHLGFLGTRHTALVSADDRGMAFSHLATRGLGSVGRTVKTTRILGRYPHDAATIGKPRKPSTVLAFAPLPLGNVERGTDTLGLTAMLTPYLLVIVSTTPVAQTQHKAARPKELAAHSALSGCLAWFPAVKLKVKDPKTGSQISKVKLVYCWSNVLTVLDVDETESSDKDKPVSLSFKPRSRWKSEEAIVAVQWLSRSVLVVLTITQRLIILEDGSMRMTEAFDLANKHIYHQDLFSNQLHTLVEQLDEEDPSMHGVVADAFFMSFKAYKSRMFLLGFNDVSIGTLSNWADRLIALMEDGDYIGAIQLATSYYTGDADKLTIGLPEDTNLRHSMVRDKLLEIMTASLKYAFGQRQNQPAEVNESHLKDLAEACFVACLNIGDIDFLFDEAYEWYEDGDSEGIFLETLEPYILDKQITIVPPTTVKSMVTHYVTKGLESRLEEMLCHMETATLDIDQVTTLCKQHNLYDALIYVWNQALNDYITPLIDLLTLLVPLIQNGDYFSTGDVMEDPIYGVNALKMFPYMSYTFTGRVYPTGDALGEQEAMNAKAEIYWFIFSGKTITWPKATGKPFLTRPSQEHEPSFPYLRMILKFDAPSFLSALNEAFEDSFLNDTPERAVNGGSNRDMPEEQVFGLSVNRQYIITILLEVMNPTDFATEDTIYLDMFIARNLPKFPQYLLLSGTALRKVLTGLCNYPGDDLAEDAQLSVEYLLSVYHPPDLGSMMPLFEKAGFYRVLKSIYRADKQYSRLLQTYFDDPEDRVAVFDCIAECLRPRSGLTKRQIKDVQEVIEKHARDLALLDPVRAAQTIESYAPLLHDKILSSLEDHSDVQYKYLQTILEPRNDDSETAKTSMNGGFVEMYVQLMCKFDPSHVADYVEVAKASDLRLDKVLPYMEERGVVDAAVILMAREGQIRQAMDRLVQHFNKLEAALLGLLSGVSDGHNGFSVDNTAESLLGALQKYTNVGVWLCQSQSKNSPQTSIVGRKKAASKTELLPEEVLWLDLIDITVQTTRKISAALSDADSASILDQEEFLPQLRTLVQRTFTALLASTSTPSATNLSFLRVLRAFLTRASLSSPNLSDLRGVLASIFSAYAYEESILSLSNRLLEKDLFVNVQSATKLRQRGWRPRGSTCEGCGRRVWGPGASGDVYAKWEERREIERRQKAERRSQISGEAPERGKGRAHVRNDSKTSILGGKDKSTPTEGVVDAEDDNPQGGTGEEPQPDLGPLVVLACRHIYHQRCLEAVQVEDAAASVVHDGREFRCPIDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMT5</accession>
    <name>A0A3D8SMT5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_03314</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SMT5"/>
    <dbReference type="OrthoDB" id="10335586at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW87620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="279" mass="31441" checksum="DF79E2DD02FB6ED4" modified="2019-01-16" version="1">MTPEGELRQGRRLVPIEAYKTFTATKPKSFSFHPAQAPTTYHQLQPSEHNIPDTRSQRLISAIKYSDSTNCLNNRSCTLNASTKMAGARPKKEIAEMFDQMALDYDDLLRRSSNASRVAFAASVETFERLTQDYLSQIQTTIDTSFAKAAGGVPDREELDIALLMVPKEFQKQVKKVKAGLAGSYSSRQKQEKKQLDRVKEKTWDTLREKLENVCAAEVRINDGQFQTSDLTSVCKTSRRLIKKEHATLPRRYVDGRPLAPSQLDDDTLASLYGVTESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SP49</accession>
    <name>A0A3D8SP49_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Copper-fist domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_03262</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SP49"/>
    <dbReference type="OrthoDB" id="10320157at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017709670" description="Copper-fist domain-containing protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW87568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="19940" checksum="69EBEF7364CD8803" modified="2019-01-16" version="1">MCLLRACLAFIFRPAAPFQSQIKHEETHPFPIDTTDTSITHSATPAVPPIAGEDDDQLTAEMEPQIQHRQQTLSRAEYAAQPATFPGLCACKAGEGCGLCIRAKVSMKAAVHVLHWGRVPGFLGSRRTRERGSGSGNGSGNSRREGTRNGNDRDGEATMDFGWRVPAREPVWAWNSDASGMDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYF7</accession>
    <name>A0A3D8SYF7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_02479</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYF7"/>
    <dbReference type="OrthoDB" id="4347at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="1223"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="1223"/>
            <end position="1248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="126"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="197"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="239"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="330"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="624"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="692"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="777"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="885"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1093"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="640"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="723"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="733"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="744"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="777"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="810"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1110"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1159"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1173"/>
            <end position="1182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1191"/>
            <end position="1207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW91314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1248" mass="137821" checksum="7E715F8C4F9AA03B" modified="2019-01-16" version="1">MDGHQYSQDGVYGVDDDDLMNTPGWPASGDQYGYPQAHQPAQDQFPQYNAGQASFSHFDLPQQGQPTYSGEAYTNSPYTTPYQTPARPSELYGTAPSYNFSNQTPAVQNPHLYASQHGAFQYGPASSLARPQAQGQGPTIAPQNLHFDPNQLRHSQGSPQPGYVQQAKRVEATQPTFHQYNQFHTQEQASKYFSNTQNAGMQHQTAQPIQPPKPAPQVGLQQPATQVAVQQAAPPAAVQQTAPQLPIQQPVQRGTVSSVSSSSTSGQQPTSRANPLRITHPLELTKLRNSPHLGVKGAPFVIVIEGKIDLPPGLKNTIPKYHPRRARSGKDLLEGLDLPDTTAQPRVAAAKKIKPPRQPKISASKYKGTSSGARQPTAAVTKLREDGTVSIRSPSLIEDTSSSEEESSSEEESEYEEDEVIIQKLEDVRAPTRPNDAAAAAGWDAIGIVWKDPRSTQSDDVKKDAIQKYGDSVVALRSQIKEVTEKIKAAAARPAELQKLNASRQVLLDSLFETINAANTLGYENIVANLGTHEKLVVALTTSLIDCVKTEDYLGKLPKAIFALLARQSVSEELLKKLKFDGIQKRWLKRGDEDIKKQIAEIQANTTEAKDKANKEKVVVDEKKKLKPQVELPKPRTHIPTKPTVTSTSTSTKRPLDHEGSNGQPTKKFASDGTTFSKIIPAKRQTNGLAGLLGSKAAATKPVVKRREPSPPRSSKLAGILDEIAKPRELPKAPEPPSGPPETPAEKKKRERKESRAHLRVKWKEGSDLEQVRLFTHEEAEDEGRQDAMLRDAHDAHSEGMMLKKRNPDDMDGDSSVDSANEEYGEIDIRPYSDLKEVDFSVLEARKLAMNYVTRGGKKAVESTEQEKQEKREALELMVVYTDLKDIPPSPREPSAIAESTQEAKDIGRPEEKWLVSRLRDIELYGPERSLQMLLRNLQYDGSSKAENATRYVIDSTTATSPTTNTPNTAHNGYIPGGEAHAWGYLNRILDESGIRGMEFPAAEPPQWMSERDKASWWEGYRIDKAAMANRLEEKRLAEEAARVQAASMITQYQMPVPAMQSYPSQPQSAPMLYNTPAVPDVTQQVNNILVNLGNGQQGNDTPPHPYDYGGWSNNNNNNNNGNNNSNNKGNNNGNNNGHNNSNNNGSNTTTDHSPSTRHEKRKSKKHAVNWDGGRDTGRDMYSESMYDEPGEPKPKRVKDRGFDMKQHSGGVPENNDAVSQYKGKKKPCTFFREGRCAKGRNCTFLHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYV8</accession>
    <name>A0A3D8SYV8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Fringe-like glycosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_02657</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYV8"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.50:FF:000036">
        <property type="entry name" value="Putative glycosyltransferase family 31 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10811">
        <property type="entry name" value="FRINGE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="9">
        <location>
            <begin position="217"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW91492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="524" mass="59613" checksum="016C16C4BA30D128" modified="2019-01-16" version="1">MAAAMASAFTRSPFIRAIFFSAFCLVLFVYTLHPQTARLQRIEENLEVYAPIHAQKPSENFQPDCSVNATNLKSLQERFGLDDQIEYAKRYVRFTRKDIPRKSITKIEEDLLPAEFETVDIRNPPKQAECYRPLEVDVPKSPYPETVDASELLFGISTTYGRLHDERIGPMKEWSHWLTDGHGNSNGAGLILRLIDASDEEIEHSKAVMKEMGIDVQVFHSDSQIEMAQRYLSLLPALYDDASRPNRKWLVMCDDDTFFPSMHALLEELGKFDSESELYIGTLSEDVNQVARHGSQAFGGAGVFFSIPLAKRVAADYDACSTPDKLREANTGWGAQGDVLLRKCIYENTDVRLTALNSLWQLDLCTDVSGFYESGGKPLSLHHFKGGMWHTAFPYEISQIAHTCGEDCILQRFQTKDNFILTNGYSIAHYPKGIDFNVNQMERTFNSAPSDLGWNMDYAFGPQRQTLIESGKKVSWELKDAIVETDGSVRQFYIRNKDDWRWKESRNGKPMFNTDGVIELIWVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZ43</accession>
    <name>A0A3D8SZ43_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_02747</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZ43"/>
    <dbReference type="OrthoDB" id="3563659at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF143">
        <property type="entry name" value="EXTRACELLULAR MEMBRANE PROTEIN CFEM DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="2"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW91582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="151" mass="16863" checksum="82E3845566CC40E8" modified="2019-01-16" version="1">MALRKKIQVMIMFSVGFFVTIISIMRLDSLLAFGSSTNITWVYVPVSYWTTIEIYVGIICVCMPAIQPLLKKVFPGILSLGTTQNTSHGSKGLSSVNSKFSSKPHVHRLGHRELHSHDDLGTFDDKASTVKLVRIETKDALRRDLRLDTAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZ53</accession>
    <name>A0A3D8SZ53_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Iron copper transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_02757</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the ATX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZ53"/>
    <dbReference type="OrthoDB" id="689350at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016531">
        <property type="term" value="F:copper chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006825">
        <property type="term" value="P:copper ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000008">
        <property type="entry name" value="Copper transport protein ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051881">
        <property type="entry name" value="Copper_transport_ATOX1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017969">
        <property type="entry name" value="Heavy-metal-associated_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46365:SF1">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN ATOX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01047">
        <property type="entry name" value="HMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="HMA" evidence="9">
        <location>
            <begin position="4"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW91592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="85" mass="9131" checksum="C3585FFD2ADFBF2B" modified="2019-01-16" version="1">MSAEHTYKFNVSMSCGGCSGAVDRVLKKLDGVKSYEVSLESQTATVIAEDSLPYETVLKTIKKTGKKVNSGEADGETKSIDLPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZI2</accession>
    <name>A0A3D8SZI2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_02869</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZI2"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF10">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="79"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="310"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="43"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW91704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="498" mass="55073" checksum="CA804D263A0556DE" modified="2019-01-16" version="1">MDYDKKPLPMESHAASEPEPVVELSDQTKALARRVIRKIDSRILLMMFLTYNLNFIDKTILSSAAVFGLEDDNHLVGKQYSWVSSIFYFGYLVYEYPTTYLIQRLPVGKYLSAVTILWGVFVAVTAACSSFGALATCRFLLGMAEATVSPAHVFITAMWYTREEIPSRTGIWFAGNSTGGFIASLAAYGLGQITHPLHSWQWMFITFGLATFLWGFVLLFFMPDTINGASFLTEEEKQYAEDRVVVAGLGRFDPVNAQWKPSQVLECFLDPKTYFFMAISICTQIPNGGTGSFGNLALKSFGFTSLQSTLVSLPSSVISMSVIMITGWLAGRYSNITSYLLIGIVIPPVVGSALIYALENKGLRLFAYYLLAFGPAAIPLALGLLSANTKGVTKKMTLTAILFITYCAGNIAGPQLFLASEAKQGYPTAFRAILICYGLVMVIAIVLRLYLSWENKRRDQREGAAAALPVDGDVKRELTAEDYEDITDMQTPGFRYRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0C3</accession>
    <name>A0A3D8T0C3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA mismatch repair protein PMS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_01421</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0C3"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000710">
        <property type="term" value="P:meiotic mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03484">
        <property type="entry name" value="MutL_Trans_hPMS_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.100:FF:000001">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000014">
        <property type="entry name" value="Mismatch repair endonuclease pms1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000120">
        <property type="entry name" value="Mismatch repair endonuclease PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="6">
        <location>
            <begin position="218"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="5">
        <location>
            <begin position="838"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="385"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="466"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="596"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="651"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="424"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="474"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00070941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW92027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1074" mass="118696" checksum="09C6BA143D4D6C67" modified="2019-01-16" version="1">MATIKPIESRTIHQIQSGQVIVDLCSVVKELVENSLDAGATHIDVRFRNQGLESIEVQDNGDGISPNNYETLALKHHTSKISDYSDLTTLQTFGFRGEALSSLCALSHFSVTTCMAADAPKGTKLEFETSGKLKSTSVVAAQKGTLVSVENLFRNLPVRRRELERKIKTEWNRVIGVLGQYACIQTGIKFSVSQQTSVKGKKTTLFSTKGNPSTKENIVNVFGAKTLTALVPLDLKLDLEPTSGQGERWSMQDDSGRKEIRIVGHISRPAFGEGRQTPDRQMFFVNARPCGLPQVAKAFNEVYKIYNVSQSPFIFANIELDTRLYDVNVSPDKRTILLHDQTRMLENLKTELTALFDSQDYTVPVSQIPTQRQPLYKQLTISRENSGLSRTGAPHTPETPARQSEVKKSENGSSPDQHSEDEESQRKDDPDYRRSALPRESTDRDRDAVDLISNWTTKIAECKPDIDPTEAVSGEDRESFDGFSKDKLAKGPEELKLASTGTDDQDGTFTSSNRSTITSSYQPPIQVVDFNRHMEELGRRHETRCMDEKIAAADATPRPALATAIPAASATSSIFSNIKGSKRPSDAMATITIGDHTITSSIGTPHPKRQKSDEESSSTRSRRHVDPTLNELPSFGKNLSQRFGALGANQQYTSSEDDQDDCGGSDLQNEESSSRPESLPLFIDQAPPEAYNHDAVSDADMVAENIHESSLNPPDEGNVSDGDYIDEEKKKAHEEARVRKMIQAVEEEAARPSQENELRAKTLLKGSARKKDSTVHLVKTLETTVAEIQKKFQTMSETLGAYQAEFVESGVDAALDSAAAEEQLSLTISKADFAKMKIVGQFNLGFILATRVSESKSQSVSETTSADDLFIIDQHASDEKYNFERLQATTIVQSQRLVRPKMLDLTAVEEEIVMENLKALESNGFVVSIDESGEAPVGQRCQLVSLPLSRETTFSLTDLNELIALLSEHPAGFVPRPSKVRKMFAMRACRSSIMIGKTLNPKQMGTVVRHMGEIDKPWNCPHGRPTMRHICGLNTWDELGWKEGNDIATDWAAYTCVDGGDDDDTLTSPERTDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0S5</accession>
    <name>A0A3D8T0S5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">RING finger protein (Zin)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_01503</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0S5"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20353">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16630">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047546">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047544">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058758">
        <property type="entry name" value="UBA_RNF216"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF42">
        <property type="entry name" value="FINGER PROTEIN (ZIN), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26191">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26112">
        <property type="entry name" value="UBA_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="432"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="292"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW92109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="675" mass="76329" checksum="0B0FCDB1908BB1C0" modified="2019-01-16" version="1">MVLSALLRPVSPKAQRRNSPPTPHNSASTDDADENAPASNPTRGSPDAQYPHCQADVPSADSVDPDLRELRDSLVALAAIFPDVQVEVFREMLCSFDRESRLAVVTEALLKNKMKWVRGRYRVASKDRGPQNMAQETPSPLELSGLVPVEEQFRTPEYKKAVKMVTYHEFKGLSRSTINGVLAEFNHSYTLARPTLVALSSKSWRFSISSLFMRRKPVSHAQAEDHPLVVWHSTGQGSIYPTIKATSSVELDRELFDSLIVPLQERMIVERETKDRELALQLNVTEAEEQDFLHDCECCFTATTFEELAACNDGGHLICFRCIRHAVNESLFGQGWQRNIDLESGTLRCVAAMSDDCHGCVPRDFVHRAFIEEKGGKDVLRKLDERLAEDNLLKTKLPLIRCPFCSYAEVDELYLPEAQRSWKLKRAGSASFYTLAIFTFGLGMVPFCLPLFMLFSVLFLFVSSRQTFGDYALSHIHSSVIRLRRKGLGLKFVCQSEHCRRASCISCQKAWTDIHICHESSLVALRTQVELAMSLAIKRTCPRCNTSFVKSSGCNKLTCVCGYQMCYVCRKDIGNGEGYRHFCEHFRPNGGRGCTECNKCDLYRCEDDEVVVKKAKMEAERAWMEKEGTALDADNALRKALEENWQHSSGSRTWWHLRMPNWQSLFDALVSGVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T137</accession>
    <name>A0A3D8T137_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cutinase</fullName>
            <ecNumber evidence="3">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_01535</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cutinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T137"/>
    <dbReference type="OrthoDB" id="2975078at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043579">
        <property type="entry name" value="CUTINASE_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011150">
        <property type="entry name" value="Cutinase_monf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250:SF1">
        <property type="entry name" value="CUTINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48250">
        <property type="entry name" value="CUTINASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00931">
        <property type="entry name" value="CUTINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="6 12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017706500" description="cutinase" evidence="12">
        <location>
            <begin position="21"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="158"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="71"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="206"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR611150-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW92141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="268" mass="27626" checksum="328E47F38B8BE72D" modified="2019-01-16" version="1">MQIRFSILFLCSFLSLRVLARPAPKSTNVQSIGSSLLSSLEQVGEQTLSSLIKTATGIVTRNQVLTNGSSCATMTVLFARGTDEPGNVGLLTGPPLFEAIADYMNGTNQLAIQGVNYDASVSGFLAGGSTQGATTMAGLINMTLASCPDTTLMLSGYSQGAQVVHLATAQLPANTTSKISSVVLFGDPKNGTAVSGVDASKVLSICHTKDDICQGGEDIRLAHLSYGLGNNGSDVKMAAAFALGGMANKGITSMFMDKVAVGQRFLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1E8</accession>
    <name>A0A3D8T1E8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Major facilitator superfamily protein-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_01635</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1E8"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF97">
        <property type="entry name" value="ALLANTOATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="460"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW92241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="518" mass="57332" checksum="C435AC9AB8C65759" modified="2019-01-16" version="1">MADIEKHHVPPTTEISPEEALSKSEIMELAAKAKLDGVHTDKGLDLFQQSLQYDTEQLARDAVKVRRKLDFIVLPMMMTTYMLSFLDKQTLNYSNAYGLQADTHMTGDDYSWVASALYFGWLVGAWPSNLALQRFPIGKFVGGMLFVWGAICMLQAAVFNFSGFFAIRFFLGFVEACISPAWVLLTSSLWTREEQPLRTSFWLSMNGMSSIIGALLSYGLGHVKGLAVPNWKVIYLVVGSMTMAWGVVISLYLPDGPDNGKMFSPYERIVAVWRISNNKTGYKNPRFLKHQVKEAFLDPKTYLLLAISASLGILNGGVANFGSALIKGFGFDALRTSLLQAPGGAFEIFGCIILGYLATCKNMMGSTIILGSLPGIAGLIGILTINIKHRYALVGCTWLQNVLGSPIVLNWTLPVLNVAGHTKRSTVLGLYFVFYCAGNIAGPHIFFAREIPRYPSAIKGLITCYAAVIVLQAIYTLTCAFQNRVRDKRGLHAMVEQEALEGFEDLTDLENLHFRYTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1H2</accession>
    <name>A0A3D8T1H2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uracil permease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_01778</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1H2"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW92384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="581" mass="64641" checksum="956915FB2DFDB969" modified="2019-01-16" version="1">MGVAKLKVQAAVKATNFRNAFRSGADFQKWIQTKDTALDAHSNNGRVQWSNEDLDPTPPAKRTWRWQNFVSFYMGISFGNWTLGSTMVGIGLNWWQSILVIFASQLISSVAMFFNSRCASVYHIGYPVVARSVFGMWGSYYFVGARAALAIIWYGVQLYSGASFMSNILRCIFGHNFTDIPNHIPESVGITSGNMLAFFLFWLVHFPLCAFRPYQLRSFFWFKSIIVIPAVWGLFIFCMANTKGNVGSVYSASFTGNKGWFIMYAINSGMGNTATLITNQPDIARWSKTKSGAQWSQLITQPLAVTLSASLGILATAAINNTWGLDLWNPWDLLSAILDRYWTASARFAVFLSAFTWMVSILGTNIAANMIPFGADSSMLMPKYITIPRGQFLVEFLAFAICPWKILASASVFTTFLSGYGLFMASVVAIMICDYFIITRGNVFIGHLYNGSSENKHYYYHKGWNVQAVIAYLCGIALPFPGFVGTLGPSVSASATELGRLGWLLSFTVSFFVYWAICTVWPTRNQALIKEMGLKWEEASDAPVVAEDGTEIVEECDQVRAVSEGSESEMGSEAYRVQEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1H5</accession>
    <name>A0A3D8T1H5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_01800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1H5"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW92406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="124" mass="14244" checksum="10E058CDF2226E37" modified="2019-01-16" version="1">MALRELHVHHSLRLTSMDLKHEQLGALEVGRLERALGLYDLRTKICTMYNTPAISHSDAVPRNKSYYFIKTSGFSMATNRSNMCEAIHYYCNYIGKVSSPHFSASWIVARVYVKFVTDELLTRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1P6</accession>
    <name>A0A3D8T1P6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Stress-response A/B barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_01887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1P6"/>
    <dbReference type="OrthoDB" id="3830014at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013097">
        <property type="entry name" value="Dabb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07876">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00886">
        <property type="entry name" value="Dabb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51502">
        <property type="entry name" value="S_R_A_B_BARREL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stress-response A/B barrel" evidence="1">
        <location>
            <begin position="6"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW92493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="112" mass="12262" checksum="AAB4327BEF08C2E9" modified="2019-01-16" version="1">MADGKVIRVTMFKIPSKADQETILANYLTLSKTQLKDGKPYILSLEAGVTEDDPRAQGYTIVAKSVFKNMDDMKYYDTECAAHEKLKVGNKALGVEGFMTVFYSPSVVAGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1S0</accession>
    <name>A0A3D8T1S0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab proteins geranylgeranyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_01900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Rab GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1S0"/>
    <dbReference type="OrthoDB" id="1923006at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017230">
        <property type="entry name" value="Mrs6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF4">
        <property type="entry name" value="CHM, RAB ESCORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037514">
        <property type="entry name" value="Rab_ger_ger_transf_A_fun"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR037514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW92506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="507" mass="55373" checksum="99BACF4FFDC1AA01" modified="2019-01-16" version="1">MESLSETHWDVVISGTGLQQSLLALALSRTDKKILHVDQNDYYGDAEAAFSLQEIEQWVEKINSDTLRPFQNASLWKSEAEAEKLSFSRAYTLTLSPQIIYTRSKLLSQLVSSKVYRQLEFQAVGNWWIYQKAGEDGTLAQGSLQRLPNGREDIFTDDNIDLRSKRGLVKFLKFVVDYENQAETWEPHARDSLHSFLSSKFKLPLSLQTIISALTLSLDAPDNTTVAYSLPRIARHLTSIGVFGPGFGAVVPKWGGGSELAQVACRSGAVGGAVYVLGTGVKNISLQKGSDEPGVALTLTNDEVIRARSLVQATDLKDEPSTRAPVVVSKTISIISSPLSALFTTTVEGAPTPAVSVVVIPAETFHVDDILQLHPVYLMVHSSETGECPVGQSVIYASTSQNASSKKLLGLCVSSFIKAIAAENAQLLYNLYYEQKQSTFESCSAGVVHHLQDPSLDLAFDDALLGNVEDAWNVTAKNIGLDDSGTFLQFEERNPMNGDDEDEDEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1S7</accession>
    <name>A0A3D8T1S7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_01888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1S7"/>
    <dbReference type="OrthoDB" id="2147163at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668:SF1">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G01940)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="34"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW92494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="250" mass="27890" checksum="A219E0030C5E1458" modified="2019-01-16" version="1">MAAHGHSAACCSIPPIISKGYEAKGKYEELGGFKTYVTGPSSGKALLYVFDIFGFFPQSLQGADILSTSDKHNQYRVFMPDFFHGKPADITWFPPDTDEKKQNMGNFFQNQGAPPKTAKIVPDLLKDIEKKYPEIKTWGIAGFCWGGKIVSLVSQSGTPFTAAAEIHPAMVDPEEATAITIPLCMLASKDEPAEDVKKFEENLKVEKYVETYSDQIHGWMAARSNLDDPKNKSEYERGYKQLLEFFGKHM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1V1</accession>
    <name>A0A3D8T1V1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Mitochondrial fission 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_01372</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="12">The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the FIS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1V1"/>
    <dbReference type="OrthoDB" id="421154at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000266">
        <property type="term" value="P:mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12212">
        <property type="entry name" value="Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000179">
        <property type="entry name" value="Mitochondrial fission 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016543">
        <property type="entry name" value="Fis1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033745">
        <property type="entry name" value="Fis1_cytosol"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028061">
        <property type="entry name" value="Fis1_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028058">
        <property type="entry name" value="Fis1_TPR_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247:SF0">
        <property type="entry name" value="MITOCHONDRIAL FISSION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13247">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 11 TPR REPEAT PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14853">
        <property type="entry name" value="Fis1_TPR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14852">
        <property type="entry name" value="Fis1_TPR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF008835">
        <property type="entry name" value="TPR_repeat_11_Fis1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 12" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014314"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR008835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW91978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="155" mass="17074" checksum="927AFF2CF2799618" modified="2019-01-16" version="1">MGSNLPYAADAESPLKPAELAVLRAQYEKEGEHVGIQTKFNFAWGLIKSNLRPEQQEGVRLLSDIFRTSPERRRECLYYLALGNYKLGNYAEARRYNDLLLEKEPANLQASSLRGLIDDKVAKEGLMGVAILSGVALAAGVVGSMIFKGMGKRAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T276</accession>
    <name>A0A3D8T276_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_01925</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T276"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF125">
        <property type="entry name" value="N-ACETYL-6-HYDROXYTRYPTOPHAN OXIDASE IVOB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="3">
        <location>
            <begin position="109"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW92531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="378" mass="41357" checksum="E803874BAA1E8239" modified="2019-01-16" version="1">MRFPWWPATIAVGASFKPATTAQTDALAAVGAWNLVNYQRSIDSECTLENAVVRKEWDTLSKPERKAYTDAVLCLMAAPSQTDPAVAPGCKSRYDDFVAVHMNQTFTIHATANFLSWHRYFTYTYEQALIHECGYKGAQPYWNWARSALDPIHSPVFDGSEYSMSGNGVYEEHNCTNALPSGLNCIPPGEGGGCVTSGPFRNMTVNLGPVFPTLAEPEVVPASSLLAYNPRCLKRDISVWVSSNYTTDAVIADLITQNPDIVSFQNTMQGDFPAGIYGVHSGGHYTIGGDPGGDLFTSPGDPAFFLHHAQIDRTWWIWQNQDLENRLMAIGGTITLSNSPPSRNGTLNDTIDLGVNAPAVPIRDIMNTMAGPLCYVYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7Q3</accession>
    <name>A0A3D8T7Q3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peroxin 22-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_00234</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7Q3"/>
    <dbReference type="OrthoDB" id="5327700at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="264"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW94471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="46279" checksum="9E11546D6D8C48F4" modified="2019-01-16" version="1">MSYDRYERGGRRPTQSSRRGTLTYWLPLALTVTAATVGIVAWIWSERNDEDDEGGPEYTGDHVRPDYGKNADGSIRTGPPSYADLRPGEAAYGTAPQTATEESASYMARMSGALRRTPSPQQIFDGVSRSAVAGVAAAGAVVGNALSSIREKDEHAYKDHETWSEEAEARRPGVSPGPAPTISSPQPGVLSSQRAPASVGNGRRKTVAVVVSADSGVHGMDDDEAFHHEHASILSHLPHNTDFSKIRLFVLIYAPDLKEHPLDSTSRSPGSLGSSFENIGNYQAQTPGEEVEKSIASFAGPAFNAVYSEALALVEKETMVFPFTSSTGHVHILRHLSPDIVYLQESLAGDNGEVITQLQSWLRQDVVIVVGADGGHGGLADSESEAEQVEKKEHWWEKEERVGRGRGVVVVEGLRVGDDWARRVEGRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8D0</accession>
    <name>A0A3D8T8D0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Defective in cullin neddylation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_00596</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8D0"/>
    <dbReference type="OrthoDB" id="27198at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031624">
        <property type="term" value="F:ubiquitin conjugating enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032182">
        <property type="term" value="F:ubiquitin-like protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.200">
        <property type="entry name" value="Cullin, PONY binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014764">
        <property type="entry name" value="DCN-prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042460">
        <property type="entry name" value="DCN1-like_PONY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005176">
        <property type="entry name" value="PONY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281:SF31">
        <property type="entry name" value="DCN1-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12281">
        <property type="entry name" value="RP42 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03556">
        <property type="entry name" value="Cullin_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51229">
        <property type="entry name" value="DCUN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DCUN1" evidence="3">
        <location>
            <begin position="56"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU410713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW94833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="269" mass="30386" checksum="6BED1D3DCF971AF8" modified="2019-01-16" version="1">MPPTPKQRQDLNQFMILTGTTERIATRYLKGAGWKLDAASDSYFAQANTAGTPAKDTSATLTKLFDKYRDEDQDEANTAGVEGTMTYLGDLEVNMENIEVLVPLEIIQAPVVGEMTRQGFVEGWKALGLDNVDKQKAYVAEQVKLLPSDPALFKRVYRHTFVCAREAGAKALKVEEALIYWGMLFSPAGRPWATATINWFELWSEFLQSKWTKSVNKDMWNQTLEFANKSMQDESLSFWSEDGAWPGVIDEFVAYVKEKRGLPEPMETD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8H3</accession>
    <name>A0A3D8T8H3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_00494</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8H3"/>
    <dbReference type="OrthoDB" id="2157866at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd13298">
        <property type="entry name" value="PH1_PH_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13299">
        <property type="entry name" value="PH2_PH_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000286">
        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336:SF15">
        <property type="entry name" value="DUAL ADAPTER FOR PHOSPHOTYROSINE AND 3-PHOSPHOTYROSINE AND 3-PHOSPHOINOSITIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="67"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="302"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW94731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="410" mass="46368" checksum="4DD8779A7DC06DD2" modified="2019-01-16" version="1">MIMADIEQAPMAASQPRAVPERTSVLHIPLSGVQLPPSSSGSRIRNANNNLDTFSPVNQNGSFEFDRVLKAGYVQKRTRKTKAWKPVYLVLRPNYLSIYKDQNEAKLRHKIILSDLTAIAFLKDPKHKRENVFGLFSPSRNYHLEAASQADAKQWVDLIRQEARIEEEEEEMFLASPGGHATGSYCGLDHEFRTQKEREQNRIHDERLGSSSPEPSDPIQRIPRKKGLSLGRRQSHTLEYSGNELASHSDMSDIETPRPLGASMVSLPEEPLAVQPPEGRPVLSGRNASQMSGINVQEDPERVVWQGYLLYLKTKRGVRQWKDLWAVVRPKNVAFYKNDSEYSPILIIPLTAVINAVEIDPLSKTKTHCMQIITEEKSYKFCAHSEESLDTSLGTFKSLLAKRKNTEPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8I1</accession>
    <name>A0A3D8T8I1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamate-rich WD repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_00598</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8I1"/>
    <dbReference type="OrthoDB" id="2161379at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051972">
        <property type="entry name" value="Glutamate-rich_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903:SF1">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="8">
        <location>
            <begin position="95"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="299"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="344"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="398"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="152"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="163"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="183"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW94835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="491" mass="54263" checksum="1FF32D348E181E70" modified="2019-01-16" version="1">MSKRPAEDFENDDIALKGGDRPEKPELDDGVGEFEDEFEDEFESEDEIFEAGVDGRPDAEREEEEKAEEMDVDQQTFIVGRNKLEPGQTLSPDLTTYEMLHALSTPWPCLSFDIVKDGLGDNRKTYPATMYAVAGTQADSKREKENQLMVMKFSGLSRMERDQEGDESSDDDDEDADPILESTSIPMTSTTNRIRAHQTPASDSSRPPTTLTASMTEAGQVLIHDVTPHLASFDTPGTIITPQQNKPLSTLRMHKSEGYAVDWSPLVSTGKLLTGDNDGKIYVTTRTAGEGWATDSRPMIGHEGSIEELQWSPSERNVFASASSDGTIRVWDVRSKSRTAAVTVQVSDTDVNVMSWSHQTSHLLASGADDGTWAVWDLRQWKPSSTSKPSKPTPVASFNFHKEQITSVEWHPTDDSIVAVAAGDDTLTLWDLAVELDDEESKDTGGNPEVPPQLLFVHYMQKAKEVHWHPQIPGALVGTGENFNVFKTISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8R2</accession>
    <name>A0A3D8T8R2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_00722</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8R2"/>
    <dbReference type="OrthoDB" id="10420592at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW94959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="219" mass="23445" checksum="0EEDEFD69A043277" modified="2019-01-16" version="1">MAPDSDPWSSLISKHITLLQEHVQILSDLHSNAADSADSSPAPSSSPDSSLVSSPEQKAAAGPPLKKPELAAMLQRAKAVLEQAELAAGKSHGKRKRTETLGASTREGVERGGKRGRPEMTADEILAKPVLIGRVQAPARRKLEKRPRESGLGLDGADEAAGMVLRKRKRDESVGEGRRAKRGRSEDVAAVEKARGRKRSRSSLGSEERGGKKRRVSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T969</accession>
    <name>A0A3D8T969_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_00827</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T969"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF3">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="37"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW95064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="324" mass="36049" checksum="D92A3C5CCF7DEAB2" modified="2019-01-16" version="1">MIPRTTHTYATSQSGALKLDVFHIPRKIALEGKRPAILYFHSGGLVAFNRELVPKHIMQSCLRRNWPIISADYDLLPQAEGTSLVDNVRDSYAFVRENLGKILGEGDGIWENIIVMGSSAGGYMANLAGHNTKPLPLAILTYYGISTVSDSFYSSNTLIHTSTPIPYSHISHFLIEETTSGSTPRSIAFNPASLLLSGDIDPHYVWPEPEDIDWNRVRSVLYNYLVQENMLPDMLKDVDHPLTSKSWKKFPDTIMIHGTIDELVPYSCSKNLVDAIGSEKAQLFTIEGADHSFDSGRLLGSPDLAEAEEAWRALDTVVEKKMKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9N9</accession>
    <name>A0A3D8T9N9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_01036</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9N9"/>
    <dbReference type="OrthoDB" id="4364at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033573">
        <property type="term" value="C:high-affinity iron permease complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004923">
        <property type="entry name" value="FTR1/Fip1/EfeU"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632">
        <property type="entry name" value="IRON TRANSPORTER FTH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31632:SF2">
        <property type="entry name" value="PLASMA MEMBRANE IRON PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03239">
        <property type="entry name" value="FTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0410">Iron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="296"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="334"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="336"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW95273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="371" mass="40183" checksum="AFDB4DD5ACD19C67" modified="2019-01-16" version="1">MTVQVFSVPVFFIVFRETLETSIIVSVLLAFLKQTLDGPHADLVTHKKLVKQVWVGCALGLLICLIVGAGVIGAFYGAGRNAWLDTEYYWEAAFALFACVVITVLGAALLRVSKMQDKWRVKLAKAMEAKSTATTTVRITRSAAFGRWCEKYAMFLLPFITILREGLEAIVFVAGVSFSAPASSVPLPVVCGLIAGSIVGYLIYKGGSSSKLQIFLIVSTCLLYLVAAALFTRAVWYIEAKKWNDAIGGDAAETGSGAGSYDVDKSVWHINFANPELNGGGGWGIFNSILGWQNSATYGSVISYNVYWIAVMLMFFGMRYKEVKGHLPFMKAKKTSAGSDSETNSGIFTEGSSEKELPKTTSGPATREVSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9V2</accession>
    <name>A0A3D8T9V2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative heat shock protein 60 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_01093</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9V2"/>
    <dbReference type="OrthoDB" id="1733909at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00600">
        <property type="entry name" value="CH60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018370">
        <property type="entry name" value="Chaperonin_Cpn60_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000592">
        <property type="entry name" value="PRK00013.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009487">
        <property type="entry name" value="PRK12849.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009488">
        <property type="entry name" value="PRK12850.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009489">
        <property type="entry name" value="PRK12851.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45633">
        <property type="entry name" value="60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00296">
        <property type="entry name" value="CHAPERONINS_CPN60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="563"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="571"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW95330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="584" mass="61502" checksum="29B9DFF2E09EA26E" modified="2019-01-16" version="1">MQRALTSRARASVLSNSSATKLRAGFGAQQLRFAHKELKFGVEGRAALLAGVETLAKAVAATLGPKGRNVLIESSYGSPKITKDGVTVARAITLKDKFENLGARLLQDVASKTNETAGDGTTSATVLARAIFSETVKNVAAGCNPMDLRRGTQAAVEAVVEFLQNNKRDITTSEEIAQVATISANGDTHIGKLIATAMEKVGKEGVITVKEGKTMEDELEVTEGMRFDRGFVSPYFITDAKSQKVEFEKPLILLSEKKISAVQDIIPALEASTQLRRPLVIIAEDIDGEALAVCILNKLRGQLQVAAVKAPGFGDNRKSILGDLGILTNATVFTDELDIKLEKATPEMFGSTGSITITKEDTIILNGEGSKDAITQRCEQIRGVMNDPTTSDYEKEKLQERLAKLSGGVAVIKVGGSSEVEVGEKKDRFVDALNATRAAVEEGILPGGGTALLKAASQALKNVKPANFDQQLGVSIIKNAITRPARTIVENAGHEGSVVVGKLMDDYGSDFNMGYDSSKGEYVDMIAAGIVDPFKVVRTGLVDASGVASLLGTTEVAIVEAAEEKGPGGPPGGMGGMGGMGGMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8TBC4</accession>
    <name>A0A3D8TBC4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Luciferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_00871</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8TBC4"/>
    <dbReference type="OrthoDB" id="5561043at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF16">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="7">
        <location>
            <begin position="33"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="500"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="500"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW95108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="604" mass="66771" checksum="660AA3BC4DD971A6" modified="2019-01-16" version="1">MAEGSATPSRPKKIMQLNFFETACTGSHMATGQWKSPEDNSRYKDRLDYYIWLARLAEKGKITSIFFADTYGIHETYQGSPAATYRGGSQVGTMDPVCIVSAMAAVTKTVAFGITGSTSYINPFILARTWSTLDHLTRGRISWNVVTSYSNSAARCMGKDKVLPSEERYKAAHEYMDLVYQLWEDCWDDGAQKWSVEPECAYDPDMIHRVEYNGKYHKMSGYGQVHPSPQRTPVIFQAGASKSGIEFAGKHAEGIYTDVSTVDAMLSYTKAVRAAAARNGRDPSSIKFFAAIMPIIGRTVEEAQAKYDYALKNISVQGGLAKFSSYTNVDMSQFPLDEPFNFEGKTADNTITGVINNFKTYSKDMSEAWTPRKLGGMLSFGGTTPMPVGTPSMVADFMEKWFTETDIDGFNMAYVSNPGSFEDVVELLVPELQKRGLMWTEYPVPGGTFRENVQCAPGQCFLPANHPAKSKFERPNYLEEERAAEEKKKLEAQAEKLKEATAIENDEGKSSAAKEQVSAVTPKETQDGEEAASLPELVSPISETPTLLAEEPESMKVKGEAESKLVEQLGVLNVDTLAQNNEYKAEELKKTETEVQVLPVVVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q4W8</accession>
    <name>A0A3D8Q4W8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_13193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000027">
        <property type="protein sequence ID" value="RDW56444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q4W8"/>
    <dbReference type="OrthoDB" id="5373426at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW56444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="416" mass="46433" checksum="56DD71C98C70DE55" modified="2019-01-16" version="1">MEASRSHSRDAMPDTGQDRSYNAITWSSIRRFSHQTRFSSLRGTRTKHAVACLLFLVCGTLFFFNGSSRPSSLPVRTGSEVHVPSNVFEVVEKSTRLNPSRKTADIVTIASAEDTFASYKHRKDCDVSSQDLHTPFTPICPDRPSMITAMSSGGRIGMDAPYMPRGCGMRWFNSEEVCEILSRFDKVVIVGDSMMRHVVGSINILVRKDIGYGAVTDWNFSAQEKKQCFCNEQFDVKACSVQGIYKTSDVESHDPSSISCAKPINVLMEEIIRVPIPPDELRRLKADILPETNKPTAVIFGHGLWNNLDVSMTLQWLDIIAEAITHVIGSRWSGLFVTPNAAGKQKADEWLVSQGNKALMVFEEEVGMGARRRGIENLGTWNMSIQASKYDGVHLDMKGNLVKAMMVMNWLNLLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q563</accession>
    <name>A0A3D8Q563_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">O-methylsterigmatocystin oxidoreductase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_13023</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000024">
        <property type="protein sequence ID" value="RDW56956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q563"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF11">
        <property type="entry name" value="OXIDOREDUCTASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW56956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="522" mass="59659" checksum="070FD577FE2DFE75" modified="2019-01-16" version="1">MDELLVMSQKYKTTSLAIILSIAAFILVWLRRDRRLDSIPGPRGYPLIGIGYKLPPKAPTVFRKWAMEYGDVFKIRVGWYDWVVINTPEAIWEILEKQAVITSSKAPSPLGHDIVTAGRRMPTMPYGPHWRAQRSVVRQITTVPMTATFVPSQEFETKQLLFDLANDNKNQRNFYQHMRRYAFSIILTNTFGTRVKDLDHPDAQNAMRSQSILRATSQPGAFLVDELPPLANLPKWLQPVKDIKMGLWGRLVKQTDSGKATHCFAREIYENRESWYSQGLTDEDLAWVAGGLIEAGFETTAATLNSIVLHLAGNQRVQSEAQKELLRVVGWDRLPTYADMRDLPYVRACIKEILCMNPILAPGIRHYADQDVVYKGHTIPKGTVLLANTAFLHYDPQRFENPTEFIPERYLDHKLYSSECAAMSDPYKRDHFTFSTARRTCPGARLTENSLDIALAGILWAFEIRPPIANGVEAEMDLSENAYVDVGLTIPKPFAVRFIPRDEKRFQIVKEQWEERPKKDMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q5C0</accession>
    <name>A0A3D8Q5C0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha-L-rhamnosidase-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_13069</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000025">
        <property type="protein sequence ID" value="RDW56604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q5C0"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987:SF5">
        <property type="entry name" value="ALPHA-RHAMNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34987">
        <property type="entry name" value="C, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G02880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017742516" evidence="1">
        <location>
            <begin position="20"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="2">
        <location>
            <begin position="242"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase C-terminal" evidence="3">
        <location>
            <begin position="570"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW56604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="677" mass="72576" checksum="86D00F5ED6621B1A" modified="2019-01-16" version="1">MLILCLAIVVAALVPPLSAQSCWRDTVCTGPSQASFSGPWDNYNYSPPSRRVKPASILSSSNDYISGFPSPAKLSGNGSILVFDFAQEVGGIVTVAYSAQGNGSLGLAFTESRNWTGEWSDDSNGSFGPDGALYANITSANGSYTMPDAKLRGGFRYLTLFLLTDSSLTLDVLDITLEISFQPTWSNLRAYGGYFYSSDETLNRIWYAGAYTLQTNAISPGTGREYPLVSEGWMNDANLGSSASSVFIDGSKRDRTIWSGDLGVAVPSILVSTGDDVGVRNTLQVQFDFQKSTGEFPMAGPPLNFYGSDPYHMSTMIAYHDYILQTNDKGFLNTTWDKYKLAMTFVIQKIDSTGLFYCTGANDWGRSSQGGHNSEANMLMYRTLVSGSSLATWAGQPDLSVNWDAVAETLKTAVNSPKNNWDASFGAFKDSDVDATIHPQDGNSLALLYNGTLTNRTASISAKLMANWNGIGAVAPELPNNICGFTSSLEVLGHLAARQSTRALNLIRLSWGWYLNNPLGTNSSAIEGYAADGSFGYRATTGYSNDLSYTSHAHGWSTGPVSALINYVVGITLTSPGGKTWALKPQFGDLESAQGGFTTSLGMFSASWSLMANNSGLTLSYDMPVESFGLVSVPVSAGSKASVILDGVNVAYSYDHSIQAIELWVGGGTHELFISYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q7D8</accession>
    <name>A0A3D8Q7D8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M61 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12556</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q7D8"/>
    <dbReference type="OrthoDB" id="626167at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007963">
        <property type="entry name" value="Peptidase_M61_catalytic"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05299">
        <property type="entry name" value="Peptidase_M61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M61 catalytic" evidence="1">
        <location>
            <begin position="222"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW57755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="472" mass="53363" checksum="8A76096EA6A5E243" modified="2019-01-16" version="1">MPSLKLLLKSSLTDQTTSYAIHVRMTLENPIIKKDEIVLHHILSRGPVKTMQYTSDDIQIKDLLGTVPVYSRDPNRSQRKFFVERDLVPGQLTIEYKAVPWNPTEASPCGPQIALERDGGGLTAAGMAFILQPAVDMPMDVSIEWDVTSTPPGTRAVCTLGEGLSVFANIKPATLDECFFAVGPLHSYPQGETGGDFGIYCTQYWPRLGFSAGEPTSEELADGWFNEGIAKYYSLFLPYRFGIFSEQELIRRLNIRISGYYTNPDRGVKNKDVQDLFWKGGHVNRIPYQRGFMYFMNLAYQLKKANARSLDELILQMVGLRNQEKPHGIAVWLSLLERELGPGVLTEYHSMSDAVPIILPPDCLRVVEKLDWTLQRQDQEEFYLGFPEDTLYTGSPVIKELDPTSRAAAAGLQEGDRITRQHSFFVVAERWGNKFSLLVKRGFQGGGREELKTLSWLPRSWEKVESYQFSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q7G8</accession>
    <name>A0A3D8Q7G8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q7G8"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW57785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="483" mass="54408" checksum="8AB7CDF9FFA57CD3" modified="2019-01-16" version="1">MGHPQSHVSQGIIHEGGREGDKRTGDTGDEKEETTGYMRNFKVVPSWWHNAREYTVLAACQPQQKAYEKVLDGKIMGGLTYHVIKSLRYLGPSYSTISYSELHRSVSLDMVDWHQTPVLLGRYKHAIFGEDEMTSFRHGTVAAVNDGNTITLDIGDVNGVCVQDIYTIYPDKFTLDFKPVNCTVHEVYQLSSLATIPTREQDVQNLKGQKVKLVRASLLNTVGIRILHSIENSQKMAVSHAGQNREIFEISGEGPPLLHLPKLPATAENTRTLVKILQHVARYKLVANLHNKTSNLHHNFVFNIQDNAGNNANPKTTKVGEILKIEFENKLQPEKDDSKNLLYLTIFNLNPLWGIRQISPEPKDQHQHIIEPGRSLEPLDIKGCTPPELRGKGLSEYTDVILAIITTRPTSFEAFTLPDLIEVWRSSEDTGQEAISNNESDLAGLLEALSTPKRHYDRVEKNTKETNGDWQTIKVLIRTEIVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q7S5</accession>
    <name>A0A3D8Q7S5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_12511</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q7S5"/>
    <dbReference type="OrthoDB" id="419598at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF7">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="19"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW57710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="349" mass="37451" checksum="99DAE0CEC245C327" modified="2019-01-16" version="1">MAPKYAQDQPAGFTNRIERVAIVGAGGRIGSFLATALLQTGKHTVTALTRQGSKSELPPGVNAVAIDYNDESSIVAALKGQQFLIITLAGSAPPDTHSKLVQAAAKAGVSRIMPNIFSTDDSNAALVSDDPLRADIKGITENITAAGLSYTYLVCSLWYEFSLAMGPLWLGFDFANKKLTLYDDGTTKVNLTTWEQCGRAVAALLSLKELPEDANDTSLTVDSWRNQPLVISSFLISQLDMFESWKRITGDKDSDWTIEKVPSKARYQQGIEAMKDAKDPMSARMGAAMASFVRLFYPNGGGDYESTRGLDNDKLGLPKEDLDAATAVAKQMVDDGYAAKLFANAAGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q891</accession>
    <name>A0A3D8Q891_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_12455</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q891"/>
    <dbReference type="OrthoDB" id="10058185at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="3">
        <location>
            <begin position="12"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW57654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="355" mass="39317" checksum="67720FF8DDA69043" modified="2019-01-16" version="1">MAQEVLKGESILVTGGEMFIGYHIVSYLLSQDPNLTISVLDHPSIIPRFPTVEYYDVDFSSQLAVTTALRSIRPTVIFHAACTYSLALPAPTFHKVNFQETKSVLSAAQDLGTVKALIYHSSSSVIEHGTSSLISATEDLPVLFAPDQKFPYPLSKALAEKLVLDANGQHGILTCSIRPAAPFGEADTETVEKLIQNARAGRANTQIGDGRNVYDFLYVGNLAHAHVLAANALLKGGRGPGGRVDGEAFQITNDEPWLFWDLTRAIAKGVGHEVKKEDIRSIPVWIAWCMAFMAEWWVWAVSRGQRQSVLTRSGIRYATKSRTIDISKAKRVLGYRPIWSMNQGLERTLKWYQKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q8F0</accession>
    <name>A0A3D8Q8F0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trichothecene 3-O-acetyltransferase-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_12515</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q8F0"/>
    <dbReference type="OrthoDB" id="1862401at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054710">
        <property type="entry name" value="Tri101-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF64">
        <property type="entry name" value="TRICHOTHECENE 3-O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22664">
        <property type="entry name" value="TRI-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Trichothecene 3-O-acetyltransferase-like N-terminal" evidence="2">
        <location>
            <begin position="42"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW57714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="475" mass="51935" checksum="A2D1C1B30BC8E915" modified="2019-01-16" version="1">MTSVNANNLNEKPAMTPVNDQCDGEEELYQDVVSQFPFLNGYSHMAFMFQPEADVSREAITAAVHEGVEKLTHKIPWLAGQVVHTSGPAGSSGLYTLAPWPSPTPKHEIIRTKDCEDLMPPMAQILRAGAPISMLDATALTPFPSLPVPHGLKPPVPVMVFQINFLRGGIIINLSTHHMAVDGTGIVQIMRHLATVLQGHEISESDVEQANRDRRRVVPLIPRGEPVKDHSYLRAPPGHVTAPPSSPPRWCYFKLPVSALPALEKLAASQPPQQLSENDILSAFCWQRITAVRLARGFSPDTMTKMTRTIDGRAAVGVPITYMGHLTYFSASQLPMGQVASLPLSTISQTLRRDLSAANTTWAIRSYATFLAREPDKSRVVYAGLRNLDTDLGTTAFIASQSTREEDSSAIPHDFGSVLGRLKYSRRPNTTPLPGGITVCPVESGAIPLLLCMPEADLEGLKKDPQWKRFARHVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q9I5</accession>
    <name>A0A3D8Q9I5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maltose o-acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q9I5"/>
    <dbReference type="OrthoDB" id="25818at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03357">
        <property type="entry name" value="LbH_MAT_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051159">
        <property type="entry name" value="Hexapeptide_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416:SF54">
        <property type="entry name" value="ACETYLTRANSFERASE, CYSE_LACA_LPXA_NODL FAMILY (AFU_ORTHOLOGUE AFUA_2G08430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416">
        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14602">
        <property type="entry name" value="Hexapep_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW58441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="217" mass="24041" checksum="C3BC3C4F5F18E249" modified="2019-01-16" version="1">MAKAVKNHELIDHVKRSAIEVPWCDEFEKMISGMNFDGSKSPLMQFYKLEVLRRLQNFNEQQIGDDTTLESLKIHRLTIAKSTLAKLGKECNIERPFFCSWGCNIVLGDGVYINRDVSIYDNAPVIIGNNVRIGPGVCICTGTHDIDPDVRRDDGGSFALPIRIEDDCWIGARATILPGVTIGRGSTVAAGAVVTRDVEEYCLVGGVPVKLIKRLRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q9J4</accession>
    <name>A0A3D8Q9J4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_12399</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q9J4"/>
    <dbReference type="OrthoDB" id="203908at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070402">
        <property type="term" value="F:NADPH binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106:SF18">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48106">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE PIG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="14"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW58469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="327" mass="35794" checksum="748DE06AE34AD564" modified="2019-01-16" version="1">MSATMEAIVIEKFGAPEVLAYKQVNKPVPKPGEVLIHVNAFGVNHAEIHMRKGEWDEWNPITGLECVGIVEACPGGEVPVGSKVMGIMGGMGRSRPGSYGEFVNVPAANVVPVDTSLSWEDLAALPEVYSTAWSCLFTVLDLQRGETLLIRGATSTIGQAAVNLAVNAGATVTATTRQESRFEMLKQMGAADVKYEQPELHKQFPPKLRFDKTLNLIGNRVLVESINLTRPGGRMLQAGWLGGLEPVVDFNPMVEMEPGVHFSLFHSKVLGEETFPLSAIPLQTIVRKIERGEWDAKPTHVFEYKDIHNAHRMLDSHKAGGKIVVKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q9N3</accession>
    <name>A0A3D8Q9N3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q9N3"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW58380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="102" mass="11655" checksum="39F4004E711939C3" modified="2019-01-16" version="1">MASWSSTLPAILGIFAVPSAVVAVWQIWKIYKEYALTNEPIVREERRGAMNQSRTLTGRHFRVATDPEMGIQRSHTVLLDSRDFQNHDEILAVPRPVVLRIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QAE2</accession>
    <name>A0A3D8QAE2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12364</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QAE2"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="29"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW58434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="271" mass="30964" checksum="2D000566FBA31B53" modified="2019-01-16" version="1">MVGTIKRAFYDSPSGQILYRYILTTKDAKRAPVVFMHQSPSCGRCYELIMKEYAERGHDCYAPDMPGFGESDDIDFMPESTRFYVDTLMGLYRHLKLPKMHLVGHHTGSAMAMEMGAIYPDEILTVCCSAPALASREEQKALYAALHEEWSKPKADGSQLMRVWDIMKDYVIGDLETKVYEVLAACRSWKGRKQAYEVLFRQDKLTFFKQITCPLIAMCAEDDVVWPNFHYVQELQPNARREVTSGDIFGSKNVEGTIAFYHVDFLDKMGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QBI7</accession>
    <name>A0A3D8QBI7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_12015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QBI7"/>
    <dbReference type="OrthoDB" id="10261408at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW59091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="637" mass="71132" checksum="A7CF7BC2CC288A70" modified="2019-01-16" version="1">MSLTRPRRRVTQACSTCRGRKIRCDAAIPKCGLCVSLNVDCTYLEPENSRIDANTRVLLERIQRLEDRLFSEPLPQIPAPAAPGHRAPRSADLMLSVHNTTQVQGLSMVSSKSPGISDTLATADNDASLLTLPAVHDANADHVYKWPIVQSLKAQQSYASASTPLPELCDATDIFILRTSKSSIPKLPLDSWRLLDHALPERSTPADVDLFTRHYEAVVHRFFINIAAFYPIIHQDTILQYLHSIIRNETSRNEIQAERQVGVSEYCLLLLVLCLGDLAKVEQVILPAWPLEPFTGYSFEAGGVSMHTPGQAPGPSSFGTSTEDILWQKALQLLSTLNSEYTLEAAQCFALASIYLAAKGQAVDSHHYIQNAAMKCKMITRRDLLENGGTANFSDIFKRVFWVVYIIESDFASEFSIALPSGITIYEDIVPYPSSTQLETQSCSVTDPEYHSPSSRLPGDTYKQSFSAYQISTNSAIRRFINRITAVMYHRKDTWQKRDPIDQVSWLEKIANELRSHHEALFKNLPSFLLSVDPPEVRNDSGLDDDPSNESNTLISPSNHTWNVTRLRGRYFAGLYIINRPIFEFAIRHPEQTSQHPAAAEIFESCRSCILGCSGFIELMFEQAANKLTGLFATGMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QBP3</accession>
    <name>A0A3D8QBP3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_12123</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QBP3"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="21"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="233"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW59199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="594" mass="68193" checksum="F086CB2B99DF16C3" modified="2019-01-16" version="1">MRLLNTHNLKIDTFFGNTPGYAVLSHTWGDYEVTFREMESLGGKEAVLSAMLLPDNRYKDYNKIVCSAEFARTRGFDYIWIDTCCIDKSSSAELSEAINSMFSWYKDAEICYAYLADVFQDHSSRFSEKELSKSRWFTRGWTLQELIAPKEVIFVSKSWQVLGTRRSLKHLIWDVTKVNESVLDGVSLDTIATGVKMSWASSRNTTRPEDTAYCLLGLFNVNMPLLYGEGKQKAFLRLQQEILRDSDDESIFAWRTSQEESQEKPYWGILAPTPDYFIGCGSLKRPRFVTRREGQPTMITNHGVRVELSLAPFRGDKSGTIFLAVLDCDVYNTGTVAAIIIQRLSDYETQYARIARTVLLEISLGLYRVPRESLNECFMVELGLGKSRGLYMSRIDEPEPQYLFVRLVPTHSRLLAGFYLEPGIAFPSVWRDNDKFVLSIHDPAQPWEEWGESDHRYHKIDLDHEYLDTTELDQLEASHRKERKVLGCLGVRVALTRGNDSERWSKPIYFVVGFGPLPENPFSTPSGYVKPWYSFARGQSAQSILQRFTHESSPRILERENLPDDYSLSINFTVGTRFAKVYYKVNVLVSKNDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QE82</accession>
    <name>A0A3D8QE82_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_11643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QE82"/>
    <dbReference type="OrthoDB" id="2444812at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="2">
        <location>
            <begin position="95"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW60037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="277" mass="30520" checksum="B5427D9B81177178" modified="2019-01-16" version="1">MTSKTPEPREAKSSASPKEVIASTKDEKWVEEHHGDAFEAAKDLGARLDSAKVSPEAVATDKGLEKEENKAAEHAPPLPEESLPPLPAEAPPAATEEDDGWAPVWDQSAQAFYFYNRFTGATQWTNPRVPEAAEASIKPTSAPSPKEPATTRPAGGYDPSIHGDYDPTAWYAQPAEVEAQPGPSTDPAAQYTATGQFNRFTGRWQAADLNPENFNDENKSKRQMNAFFDVDAAANSHDGRSLKAERSGKKLSKTELKQFKEKRKAKKEEKRRAWLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QED6</accession>
    <name>A0A3D8QED6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_11812</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QED6"/>
    <dbReference type="OrthoDB" id="3061561at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35043:SF7">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW60206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="397" mass="45245" checksum="27DEC66F6692D439" modified="2019-01-16" version="1">MPTILSHLFTRRDEHTTSLIPQIPGSFTVECTLPPQTTNFITAPNARGTLEILESGFLCVLVCIWTVQHLNVPQQRDGRSRGLSGKWYWQLKLLRTRLKWMLVTLILPEFLVGKALSDFMGARESMKRVRELRDVEGKPLADEEVEGWTKVHAFYGDMGGFVLRTNRPRSNGEGFALQHLVSEEVLRLREQGTITRLPSIHKDRIVAMSKGDVFVKLLAVFEITWMVIEVSFRKAYDLPISQLEITACAFCSTTLVTYALWWTKPQGVKIATIIPLAPSASTELLFEPRLPGFWRYRLAHFDSDALRQRDRPDEPVSMERLRARTSSARSSSTPITQHGDARHWHHNRQHPARMRASHSLELPVPVTHRATALAVLLHRHHLGDPIILPGLQHHRGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QHK1</accession>
    <name>A0A3D8QHK1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_11215</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QHK1"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015137">
        <property type="term" value="F:citrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000172">
        <property type="entry name" value="MFS multidrug resistance transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF26">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="182"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="217"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="240"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="486"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="514"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="574"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="151"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="93"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="43"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW61323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="654" mass="71867" checksum="C710F98E40546CA5" modified="2019-01-16" version="1">MSNPNLPRPDMAYYPQGSAPEYSQQQGYGKLEERPARPKISFASHTRQPSSTSNNRDTRLTLDGGWVLARRSRIPSKAWNRQSIQIFADFHDFDSPRGSRSQRAAEREDDDDESMPSGHTRNSSISSIASLDKALPEPPYHIFTLAKKKQLVYIVSLAGLFSPLSSNIYFPALNQISTDLKVSVSLVSLTITVYMIVQGIAPSFWGPFSDTIGRRPVFVGTFLVYLAANVGLAFSDSFAALMVFRGIQAAGSAATISIGAGVIGDITTARERGGLIGIFGGIRMMGQSIGPVFGGIITQYLGFRAIFWFLFGLGALTLGLIVLLLPETLRSIAGNGTVRLTGFQRPLLYSFKEQPEVLKESESDTPKRTVTWSSLISPMRFLFEKDVFVSLFFGSIVYTVWSMVTSTTTDLFQTRFHLNNLMIGLAFLPNGAGCVAGSYLTGYLMDYDYRTVESQYKKERGIPDDMKLDKKTADGFPIEKSRLRNIWWIVLIFIITTAVYGFSLNLNILAIPLILQFFIAYSATAVFSLNSALVIDLYPGASASATAVNNLMRCSVGAAGVAIAQPIIDAIGAGFTFFMLALITGVLSPLLVVEWYFGEQWRLERVARLKRQKEIKATRNALETTSVTVLEKVTVDTVPGNKKPAGAKGMENKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QIK6</accession>
    <name>A0A3D8QIK6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_11469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QIK6"/>
    <dbReference type="OrthoDB" id="3454835at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="2">
        <location>
            <begin position="37"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW61577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="201" mass="22591" checksum="57F343725BF43185" modified="2019-01-16" version="1">MPHKPIPHTFTHPELSYDAKPNIQPCIKLSFFFNKLPEVSHEHFYRHWQTVHADLTVATKDFAICNLKRYVQLAPATPKQIAQTPSLATQAKTALTGLNVLEFDGCSEIWVREWGDWMKFFQSPEWITDLNPDSVHFMALPISVMVGQENLIFGKAIEGMGGTDGILEWREKADGRVQEGEGAMGAAEEGVGAREVRVARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QIQ9</accession>
    <name>A0A3D8QIQ9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_11529</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QIQ9"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017495444" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="26"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="49"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW61637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="545" mass="58946" checksum="D79B6D5364E4E67C" modified="2019-01-16" version="1">MQGGGLSYAIFLLAATLAASRTVVADSTGGTPIVDLGYATHQASLSISNQSNVYYNFSNIRYAAPPLGNLRFEATQPPLNNRSAGVQDGSYGNICPQAYAEWQLGNLSLLDGAPNENEDCLFADVIVPKAIYDNKSLNQSKPVPVIVWFYGGGFTLGSKYSAGNPTGLLDQSLNTSTSGQIFVSFNYRLGAFGWMNGPEFAAVGTPNAGFYDQRTLLLWVQKYISLFGGDPDHVTVMGESAGAGSILHQITAYGGVEAPFHQAIMQSPAFIPRALKNQTNTAFEAFLAAANVTTLAEARLLDSKVLQKANKLVQATAFYGSFNFGPSPDGTFVPDLPGKLLLEGKFDHNLTIIAAHNSNEAGRYTPPTATNSDNFTTFMLDYFPELSTSQLAYLTNVLYPAIYNGSQPYTTPFKRLDLAISDFTFTCSTKSLGRAFGNSTHNYQFSVPPGNHTEDVPYTFFNGPISTVKNGTLAMTLQRYLTGFADKGTPNQAGLPYWTEYGTAGKVLNFNVTESNSVSLDTIVDTATVNIRCDWWQQGLYGDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLF2</accession>
    <name>A0A3D8QLF2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mandelate racemase/muconate lactonizing enzyme C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_10958</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLF2"/>
    <dbReference type="OrthoDB" id="17395at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050032">
        <property type="term" value="F:L-rhamnonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03327">
        <property type="entry name" value="MR_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000005">
        <property type="entry name" value="Putative L-rhamnonate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023444">
        <property type="entry name" value="L-Rhamnon_dehydrat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046945">
        <property type="entry name" value="RHMD-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011968">
        <property type="entry name" value="PRK15440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794">
        <property type="entry name" value="ENOLASE SUPERFAMILY, MANDELATE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794:SF58">
        <property type="entry name" value="MITOCHONDRIAL ENOLASE SUPERFAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00006">
        <property type="entry name" value="rhamnonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="4">
        <location>
            <begin position="171"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW62656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="438" mass="48536" checksum="2EFB80774FAFE564" modified="2019-01-16" version="1">MASTVKSFPKIKAIRSYVIDGVGSGGDYHNVKGGHWLIDTPISTPMSRWENYRASRTSWGINVLGSFCVEIESDDGTVGFATGFGGPPGCWLVHQHFERFLIGADPRDTNHLFEQMYRGSMFYGRKGLPVAVISVIDLALWDLLGKIRNEPVYKLIGGATREKLDFYCTGPEPTAAKAMGFWGSKVPLPYCPEEGHAGLKKNVEFLRKHRESIGPDFPLMVDCYMSLTVPYTIEIVKATLDLNINWWEECLSPDDTDGFALIKRAHPQVKFTTGEHEYSRYGFRKLIEGRNLDIIQPDVMWLGGLTELLKVAAMASAYDIPVVPHASGPYSYHFVISQTNCPFQEYLANSPDGKSVLPVFGDLFLDEPIPTKGYLLATDLDKPGFGLTLNPAARLIPAQYLLTPNPERPLGGKLAIEPKKIEDEGVMNGIVKGVKDMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QM15</accession>
    <name>A0A3D8QM15_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">General substrate transporter-8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_10992</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QM15"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005366">
        <property type="term" value="F:myo-inositol:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904679">
        <property type="term" value="P:myo-inositol import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000073">
        <property type="entry name" value="MFS myo-inositol transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF12">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="85"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="137"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="377"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="466"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="496"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="45"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW62690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="544" mass="58947" checksum="A270FA8D086232C3" modified="2019-01-16" version="1">MADAADEPLMRHSVDDEATQDVDLSDVSLLLEKNLKHPGIYVWLLTFSAGISGLIFGYDTGVISATLVSINDSLGRPLSTLDKSLITSCTSLFALFLIPTSSILADSMGRKSVVLLADLAFILGAIVQATASSVWQMIIGRSIVGLAVGAGSFVTPLYIAELSPSPFRGRLITLNVLFITLGQVVAYIVGWAFVEWGNRSTAWRWIVGLGAVPAALQAVTLLTMPESPRFLVQNGQHGQARNVLNKVFGKGIEVQKMVDGVLRGIEIEVREEDEAKRSRMKNRPTKVAESWLSLAKDNWQELFRNAGNRRALTISCLLQGLQQLCGFNSLMYFSATIFTLLGFSSPTLASLSVALTNFFLTCVALGLIDKVGKRKMLLWSIPTMTLGLLLCSAGFYLITLPADLNAENPATSPTAYKTIPMSERTIPLLVLVSVMVYVGAYALGLGNVPWMQSELFPLNVRSMGSGVATATNWSSNFIVGLTFLPMMEFLTPSVTFLIYAGICLAGWLIVLRIYPETTGLSLEETGALLATGWGVNQASRHTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QU88</accession>
    <name>A0A3D8QU88_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidyl-prolyl cis-trans isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_10029</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QU88"/>
    <dbReference type="OrthoDB" id="2530521at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.10:FF:000066">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000026">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051370">
        <property type="entry name" value="PPIase_Pin1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000297">
        <property type="entry name" value="PPIase_PpiC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10657:SF4">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00639">
        <property type="entry name" value="Rotamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50198">
        <property type="entry name" value="PPIC_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="WW" evidence="6">
        <location>
            <begin position="16"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="PpiC" evidence="7">
        <location>
            <begin position="80"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW65337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="196" mass="21959" checksum="61B0A87042D61CB4" modified="2019-01-16" version="1">MIVYVVNIDIPRKADAGLPSGWEVRHSNSKNLPYYFNESQKSSRWEPPSGTDTEKLKEYMAKHHSAPEIRPEAGGMNGKEGKIRASHLLVKHKDSRRPSSWREAEIKRTKEEAMSIILAHEARIRSGQKSLGDLAISESDCSSARKMGDLGFFGRGDMQKEFEDAAFQLKPGEVSNVVETASGLHLIERREVLPPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUD9</accession>
    <name>A0A3D8QUD9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Allantoin permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_09993</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUD9"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="300"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="350"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW65301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="574" mass="63654" checksum="C6CC066C21213E64" modified="2019-01-16" version="1">MALTSVSPHELQKQARTKVENFRAALKSQAAFKAYIQTEDSEEGGSWSWTNEDLLPTPLHNRTWRARNYIFFYSSLAMDNWTLGSSLIGVGLNWWQAIISILIAQIIGASASAFNSRCAEKYHVGFPIVARATFGMYGAFYAVGARAVLALIYYSLKLYVGSSFMVNMLHAVFGTGFTSIPNGLPESVGFTTQQMLAFFLFWLCHIPFAFFRPNQLKWLFTLKMCMMIPAMCGLFIFCMVNTHGKIGAGHLTSAIPTTSTAWLFMYAINSSIGGHSTLITNQPDYSRWARKPWSSVWTQLIFWPISVTISASFGILSTAAINNVWGLKLWNQWDLLTAILERYPSSGARFAVFLCALFWAVLVLGTNVAANMIPLGSDCAMLLPRYMNMIRGQVLGLVLSWAICPWQIYKSAATFTKFLSGYGLFMGGLTGIMVADYFLSRGNLFLGHLYDGEKSNPAYYYIKGWNVQAYIAYICGFAIGIGGFAGNLGASVTSRTSEVGYLGWIMSFSVSMIVYTFLCLLWPTQSQRLVKSLRLRWEEKAPLEVDTGLSDESSVEAGQVIEIANEGSKGVKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUS9</accession>
    <name>A0A3D8QUS9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Short-chain dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_10305</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUS9"/>
    <dbReference type="OrthoDB" id="5336600at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669">
        <property type="entry name" value="5-KETO-D-GLUCONATE 5-REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43669:SF4">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW65613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="24859" checksum="627213D5B8A04297" modified="2019-01-16" version="1">MVNVSPVILILGAGPNVGQHVARAFAAKGYKVALASRRLKEDDSTADEVHISSDLSDPSSIVRVFSKVKALLGFPSVVVYNAGAVTPTDGKTPLALPLADFTRYFNINTTSAFVAAQQAVLGFEQLSDSASKTFIYTGNILNTTTMPALMDLGIGKSATAHIIECAAQAYKDRGFKFYYSDERKADGKAVYNDINGEAHGELYVQLAEGKSQGPWQQTFVKDVGYKHFPAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QV27</accession>
    <name>A0A3D8QV27_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peroxidase</fullName>
            <ecNumber evidence="11">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_10311</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8 11">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="8 11">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="8">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peroxidase family. Ligninase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="11"/>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QV27"/>
    <dbReference type="OrthoDB" id="2113341at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001621">
        <property type="entry name" value="Ligninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF66">
        <property type="entry name" value="CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00462">
        <property type="entry name" value="LIGNINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 8" id="KW-0349">Heme</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 11 13" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017495540" description="Peroxidase" evidence="11">
        <location>
            <begin position="18"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="12">
        <location>
            <begin position="114"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="124"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="125"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="272"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="9">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="90"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="10">
        <location>
            <begin position="111"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW65619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="417" mass="44520" checksum="FD8457426C6A9D79" modified="2019-01-16" version="1">MKYNLIFLTAAASAVSAFPGMKDLMADLGKRQAETATVELLGDLLDGATTPVGQEVKDCLLGNVACQDPSKKTYAPPGPLGSPACAEDTCCVWDFIQKDLTDLFLDCDGTCNELARGAVRFGFHDAAAWSKTSGFGGADGSLLISKDEILRSENQGMDDIYAAGNDLLAKYSEYGIGAGDLVQFMHNTATVLCPLGPRILTYVGREDSENNPTGLLPDTHSPAPVLIELFQDKTINFKDLIALIGAHTVANQQFVDPSQAGAPLDSTPGIWDVKFYNETLQATPPPGVFRLPSDESFKNDNATAPGFTVFSDPVTGQTTWNAAYSVAYVRMSLLGVNNINELTDCTKVLPDQVFDFTPKACPSSSSSSSYTSTTSTTSIQILHDHTTMAPMVTPAPETDSYDSYGTTTAYVTVTVEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QVB1</accession>
    <name>A0A3D8QVB1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7582 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_10136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QVB1"/>
    <dbReference type="OrthoDB" id="5350192at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056004">
        <property type="entry name" value="DUF7582"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24483">
        <property type="entry name" value="DUF7582"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7582" evidence="2">
        <location>
            <begin position="165"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW65444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="454" mass="49471" checksum="67237AA84E2BCF91" modified="2019-01-16" version="1">MPAITKDLISPPLEAGPSLLDTNQLPPQLCSALDYVSTRLARKRLHITLVAMRKDVQLPTSPPPSPPLPAPKSRFEPFTRSLSKHSSSLSLKSSSSATSSNSKESLRITAPAPTSPTLTTTISYSRTQHPSLPSSPRPISPTSTTSSESSSPSLSPCSSPIMPNSYGISLLHATSLTPKAEKILRSIVAKAEKKFDIGSAWLSAQPLTTSSRCAMTNDLIRRSITQNEIIFCSEGLTLLSLCHIYTFKCYLHNYSRLLTPAALTAGVDELQRLVLAHHGRRITKGYLIRTYSWLGVSLSALVDVNEGYKKSYGGIERLSGIEISNEERHSPPPLKTEFGRLAPPPPRRPALQLAYLDTRREVVEVGESAKGRDITLSPAASLSSHHTSVSYNQDSVTKKFYNDLTSFREDRGPHLRGPVTPNDYGDITPITKGEWKFLIVGDGFGTKTGPLEVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYK4</accession>
    <name>A0A3D8QYK4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">VLRF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_09618</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The VLRF1 domain mediates binding to the 60S ribosomal subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ANKZF1/VMS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYK4"/>
    <dbReference type="OrthoDB" id="429841at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047139">
        <property type="entry name" value="ANKZ1/VMS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041175">
        <property type="entry name" value="VLRF1/Vms1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036">
        <property type="entry name" value="ANKYRIN REPEAT AND ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16036:SF2">
        <property type="entry name" value="TRNA ENDONUCLEASE ANKZF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13857">
        <property type="entry name" value="Ank_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18826">
        <property type="entry name" value="bVLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52044">
        <property type="entry name" value="VLRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VLRF1" evidence="13">
        <location>
            <begin position="236"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="10">
        <location>
            <begin position="485"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="114"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="283"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="561"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="561"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW66869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="635" mass="69967" checksum="56F3BFD96F4EFB55" modified="2019-01-16" version="1">MDQRKEEVTRRPLYVYDLPQDILATLERADATGLGPVATDLEDDSPVPETILESKAENGGSKSCSLCGVTFPTLEDQRSHNRSDLHSYNLKQKVRGAKPVSEVEFESLIKDLNESLSGSDSSSDEDEETSTRKETTLSALLKKQAAISSNNNTEEEDNFARKTRKQGSGKAPLLWFSTPTLPPNTYLGFYRAIFTNEEQENDSNALDIIKKKQLAPKPQPKPAEIQNGIPLPSAYTGPHFFLCMIGGGHFAAMVVSLAPKQTKSASGPMSREATVLAHKTFHRYTTRRKQGGAQSANDSAKGAAHSAGSSLRRYNEQALTEEVRLLLQDWKGMIDTSELLFIRATGNTNRRTLFGPYEGQVLRQNDARIRGFPFNTRRATQSELMRSYIELTRVKVTEIDVAAISAAKAAAEEAARQSAAAKAAKKVAPAAPKISEEEEIALLHTSQVQALIRRSKLPALLSYLSTNEISPDFVFHPKDTQQNHHAPTALHLAASQNSPPLVTGLLIKAGANPTIRNGDGKTPFELAGDRSTRDTFRVARSELGKDKWDWDAACVPAPLTRKEADERDARERMDEAKKENARRKAEEERLKEEGPKVTDDGKLGRAAGRGRSKVLGQAYRNSRQEEVKGLTPEQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYU1</accession>
    <name>A0A3D8QYU1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Probable endonuclease LCL3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Probable endonuclease lcl3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_09473</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYU1"/>
    <dbReference type="OrthoDB" id="10023235at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031332">
        <property type="term" value="C:RNAi effector complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004518">
        <property type="term" value="F:nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031047">
        <property type="term" value="P:regulatory ncRNA-mediated gene silencing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00175">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000010">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.140:FF:000018">
        <property type="entry name" value="Serine/threonine-protein kinase 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000001">
        <property type="entry name" value="Staphylococcal nuclease domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000019">
        <property type="entry name" value="Transcription factor (Snd1/p100), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000030">
        <property type="entry name" value="Transcription factor (Snd1/p100), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016685">
        <property type="entry name" value="Silence_cplx_Nase-comp_TudorSN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF2">
        <property type="entry name" value="STAPHYLOCOCCAL NUCLEASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017179">
        <property type="entry name" value="RISC-Tudor-SN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TNase-like" evidence="10">
        <location>
            <begin position="82"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="10">
        <location>
            <begin position="245"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="10">
        <location>
            <begin position="397"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="TNase-like" evidence="10">
        <location>
            <begin position="563"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="domain" description="Tudor" evidence="9">
        <location>
            <begin position="776"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="43"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="694"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="58"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR017179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW66724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="960" mass="106121" checksum="19B9D34CA8BA2BB0" modified="2019-01-16" version="1">MKEVKVGYASGSSGRSNLARSNSSVSRAAGSFIEASYANLVAPFPSPSSTPTPPLSPKRSRKSGFKKHLLPSVPPARYDTMVLNQAKVKSVLSGDSLVLTSIDNPQAERILSLAYTTSPHLKKEGDEQWAFESRDALRKMVVGKTIQFQVLYAIPNTKREYGIVFLSDGRRLPEEMLKEGWLKLREDAGRKEDSEEALQQLDKLRLLEATARSEDKGLWQSGGGRIDVQHDMGDSNEFLETYKGKTVDGLVERVLSGDRMLLRLIVSPTKHYQVMTLVAGIRAPTTERVNPSNQQVQPAEEFGNEARQFVEDRLLQRNVKVDILGLSPQRQLIASVKHPRGSIALFLLDAGLARCTDFHSTLLGTDMAPLRQAEKNAQSKKLGLFKDHVAKANVSGGNLEATVTKIFSADVLFVRNKAGAEKRINLSSIRGPRPTEPSEAPFRDEAKEFLRKKIIGKTVRLSIDGSRPATGEYDAKDVATITFNDKNIGLILVQEGWASVIRHRRDDTDRAPNYDELLAAQEEAKEAKKGMWSGKPAKAKVYADASESVQKAKIQLSTLQRQKKIPAIVDFVKGGSRFTVLVPRENIKLNFVLGGIRAPKSARNPTDKSEPYGQEAHDLAAKRLTQRDVLIDVHNIDKVGGFIGELFIGGESFAKILVEQGLATVHGYSAEQAGNANELFAAESRAKEARRNLWADWDPSQDAVEEESTHTNGDSNGDAPIERKPDYRDVIITNIDAAGKLKLQMIGTGTAALETLMSQFKSFHLNPTNNSGLPGPPKAGEYVAAKFTEDQQWYRARIRSNDRAAKEAEVVYVDYGNSEKIPWSRLRPLTQPQFSPQKLKPQAVDATLSLLQFPTSPDYLADAVAFIMDNFMGKELVANVDFTDSKENTMHVTLYDAANSENMTESINADIVAEGHAMVPIKLKGWEKSFGDVLKTLKGKEAVAKEKRYGMWEYGDLTED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R2V2</accession>
    <name>A0A3D8R2V2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alkyl transferase</fullName>
            <ecNumber evidence="3">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_08927</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R2V2"/>
    <dbReference type="OrthoDB" id="4173905at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904423">
        <property type="term" value="C:dehydrodolichyl diphosphate synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016094">
        <property type="term" value="P:polyprenol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01139">
        <property type="entry name" value="ISPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018520">
        <property type="entry name" value="UPP_synth-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291:SF43">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01066">
        <property type="entry name" value="UPP_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="183"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="186"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="208"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW68270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="356" mass="40067" checksum="E04C2D662E6A505C" modified="2019-01-16" version="1">MSMSVRNFFLSSPPVEWAVNQLRELLIGALRQGPIPQHVAFVMDGNRRFARTHKMETVEGHNLGFEALARILEVCYKSGVRTVTVYAFSIENFNRSKYEVDALMEMAKVKLQQLSQHGELLDRYGASVRVLGSRTMLKPDVLAAIDKAVEMTQNNGDAVLNICFPYTSRDEITTAIKKTVEDYSTPLHSQARPFSQTRITQKIRSRNLSTSPLASSPLRASSPAPSSISDLDESVSSSTTLHPDSPPTDSRSHNNAIYQDPETITSETLDQHMFTAGNPPLDLLVRTSGVNRLSDFMLWQCHENTKMVFLDCLWPDFDLWQFLPVLVEWQWQQKYLEDKSVGKVGASKSAKALKVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R2Y7</accession>
    <name>A0A3D8R2Y7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_08993</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R2Y7"/>
    <dbReference type="OrthoDB" id="2365484at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06090">
        <property type="entry name" value="KOW_RPL27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.770:FF:000001">
        <property type="entry name" value="60S ribosomal protein L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001141">
        <property type="entry name" value="Ribosomal_eL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018262">
        <property type="entry name" value="Ribosomal_eL27_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041991">
        <property type="entry name" value="Ribosomal_eL27_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038655">
        <property type="entry name" value="Ribosomal_eL27_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10497">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01777">
        <property type="entry name" value="Ribosomal_L27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01107">
        <property type="entry name" value="RIBOSOMAL_L27E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW68336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="156" mass="18073" checksum="784D3C44B6FEF210" modified="2019-01-16" version="1">MKFLKVGRVAIITRGRYAGKKCELGEGLKTNSETEVLTEELQVVIIQPQDNGNKSHPYPHALVAGIERYPSQITRRMSKAKQTKRSKVKPFIKVINYNHLMPTRYTLELEGLKSVITAETFKEVSQREEAKKTIKKTLEERYTSGKNRWFFTPLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R3N6</accession>
    <name>A0A3D8R3N6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_09227</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R3N6"/>
    <dbReference type="OrthoDB" id="3543857at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="3">
        <location>
            <begin position="356"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="327"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="388"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="432"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="539"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="556"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW68570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="581" mass="65597" checksum="0FF492345E0EE612" modified="2019-01-16" version="1">MSRLEDQQRRKKHKIVQNIINNNNTPTILQCSFDFTVRERVKYIPGSSGPPLAPISIMPVHDKDGIILDYMLVNGGPHFLIGYKDSRLQIIAKPQHILDWVSQRTFEDYEYEQTTLRLRQEEEELLPQILAKEERRRKREEKLTASRAQGPKKTWSRKRKRPPTPEPAPKKEGGRARGLGVRLSPSEGFATSGPARTRRKVKPEPTFVSPRRISHPQPQQPSLTSPLNGKGRTHGDVVSIDSESEETDTAISRQLGLTSRGRSRQSDPPSADLSNAEFPPKRKVSRVVRKTEQKKSPYKPGSIAQKYSMFATSPWMTTATQNVIVSSHEPETDDKEGSDSEIDEAPLAEGEEGEEYEVKAILAEEYRKVEGKRVLYYLIDWEGDYTPTWEPSSMVGTGTRMEWEKKKKKKAAEKHDEKNTKDSQKSIQLSHNGKDRGRSKDDDLKSSDAGSKFGSGPEFEESDQDTLFVSEKPAFSRGSNIRGSIEHKNKNSSHSRGTQKPYPAATSINMDIDNGISDEDEDGEMYGNEIARHLHDPHGSSPEGSPSEMAVDDEDRAGAHPPDTEIYDHEHGENPEVWYEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R4A1</accession>
    <name>A0A3D8R4A1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R4A1"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017568749" evidence="1">
        <location>
            <begin position="21"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW68644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="77" mass="7868" checksum="D909FDCF3319D987" modified="2019-01-16" version="1">MQFTHILMAAATIFATAAVAGPSHPNLVPRDGTCSNGQGCLGATCCYSGGCCYACSEGSDAECSPEITERTIFAETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R801</accession>
    <name>A0A3D8R801_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Spindle pole body-associated protein cut12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_08435</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R801"/>
    <dbReference type="OrthoDB" id="5383703at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021589">
        <property type="entry name" value="Cut12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11500">
        <property type="entry name" value="Cut12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spindle pole body-associated protein cut12" evidence="2">
        <location>
            <begin position="162"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="611"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="545"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="735"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW70038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="761" mass="85113" checksum="1ED202CD8935B9AE" modified="2019-01-16" version="1">MLNWWLGKSSEDLRRVDVDQEPPETPAPVFAARALKSAFFGTPAPPNDDTFLELDRQREGLEPSDMEPGGRNNSPAKPAGILMTPGTAAARRKTVSFHNEVFDYGGKDKGGQSGVPDDCPGKFPSPWTAKSEDRSARKTPLTRTLEKVREGRSDRMTQAQGKSSLRHELHESEINGDAAGSPSSKQQSLALEREESRSGKISRERIPRDDLDGDITLDLNEPHSQSGRYWKSEYDQYHEEAKSEMTKLLKYKHLAKSYAKKKDAEAIDLGERLKEEQRKVAIMEEKISDLSAQVVASQSGSDNNSTSLTNELERQKTLVAQYKALVEDLKVEYKAQGGKVDADAERRLTMPDRISSEMQKELKRVRGEMTKFRDEARTLRLDLSAAERKYLRLSDENAKLAGELQRTKVELENSEKRRQELEGQHPEREGSLQALQKDYDRLKDFAKTTRQNAMEITAHQKDQIRRLEKELSDAQDSVQAYKSLIIEKLDVLDNPEKASLMEPKGGNGIHRVGSQSRFSGSRQLESTLNNSGRNTAGDIAGPSKPATSTDNVSLRRSNSESRLPPRRPNSTAAVDVDSRPRDEDTPRKRVSGLPKITPYANRFSNLTMESPLMELPSPEPSLPTHPRRTVNGKANGESSRPISAHIPSSPPKFLSARSQSVDMTNYETQNDRSLLSRQRSTNSASGRVGHLSHQKSNSSLGGNERHSLLPTKSLATEGSRARNTLPPERAAAAKARLEQRMAEKRNQKSRDVDWDKENVRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R826</accession>
    <name>A0A3D8R826_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS10m</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">37S ribosomal protein S10, mitochondrial</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Mitochondrial ribosomal small subunit protein 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_08592</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R826"/>
    <dbReference type="OrthoDB" id="366214at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000003">
        <property type="entry name" value="30S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="8">
        <location>
            <begin position="101"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="49"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00078476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW70195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="267" mass="30343" checksum="1FF9F375A4287687" modified="2019-01-16" version="1">MSELEPSNCNDPLLFFAPIFDWGSKLEPRITAYSPGIQTRVEVRRYASSPASRSNPSVQAPKSQPVTLEKEDNELRLPRSVQAVYLKPLRREAKYGVPSCDLQMRSYNVRNLEFFADFALRAAYYLNLPAFGPVPLPRITERWTVPRDHFIYKKSQENFERKTLRRLIQIRDGHPETVAIWLAFLKQHAYYGIGMKANMWEYSEIGVGKSMDVDMQKMKADLDPQLAQFGPGMTQDTAKKVAELLNSEAFKAAAGGNAPLMGKTLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R896</accession>
    <name>A0A3D8R896_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Tetratricopeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_08666</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NCF2/NOXA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R896"/>
    <dbReference type="OrthoDB" id="9450131at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000017">
        <property type="entry name" value="NADPH oxidase regulator NoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000246">
        <property type="entry name" value="NADPH oxidase regulator NoxR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051864">
        <property type="entry name" value="NCF2_NOXA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053793">
        <property type="entry name" value="PB1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175">
        <property type="entry name" value="NEUTROPHIL CYTOSOLIC FACTOR 2, NEUTROPHIL NADPH OXIDASE FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15175:SF0">
        <property type="entry name" value="SH3 DOMAIN-CONTAINING PROTEIN C23A1.17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54277">
        <property type="entry name" value="CAD &amp; PB1 domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51745">
        <property type="entry name" value="PB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="6 7" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="36"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="PB1" evidence="9">
        <location>
            <begin position="448"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="247"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="250"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="303"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="340"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="381"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW70269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="544" mass="61373" checksum="1281B97AD84631A8" modified="2019-01-16" version="1">MSLKQEIETWVAALGHYDNNEFDEALREFDGIADTSKILFNCGVIHATLGEHEKAVECYQKAVRLDQYLAVAYFQQGVSNFLVGDFEEALANFNDTLLYLRGNNMIDYAQLGLMFKLYSCEVLFNRGLCYIYLQQKDAGMQDFSFAVKEKVVEDHNVIDDAIREEAEGYTVFSIPVGVVYRPNQAKVKNLKTKDYLGKARLVAASDRNNAFTGFAGSEIKNAGKLDVKDDRPQENLSYAATNLVKPGLQSKASVPEPQSFNRGPPGGAFPPTPPPENERSAPSQMSRGASVRNGPKPMPARLNMDRARPNERYDVRDARSPPQRMPTQRMASEPRGPPARSNTNGGSQSRAPSRRPDNRRRAEDEDDAYPDELYDMYSTPNRNSRGNRSNGNRRTQSRYEDEDEYASDYDDGSFDEGDFEMVSKANPPPRSRAASSTRGQSRKPDIRKIRVKVHSEDVRYIMIGAAVEFPDLVDRIRDKFGLRKRFKIKVRDEDTPNGDMITMGDQDDLDMVLMSVKANARREKADMGKMEVSILRIILSVDPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8A3</accession>
    <name>A0A3D8R8A3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8A3"/>
    <dbReference type="OrthoDB" id="4463286at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="295"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW70161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="435" mass="46247" checksum="210F1E23EAD49D9B" modified="2019-01-16" version="1">MSAAIAMAPSPAPHDRSSYIDIAPSAPATSSHSPPAQRVTSVSGTPIVTAQRTGSGSPKTTPPASKSSPNLSRGAAPPKIIVKKEPSSPELPASRHRPRKLDLSKNTASANPATSRPSAGQLTSRGEGSGLGIIDVGLACLSPGFVTQDPTMREQLQRSISVREQQRQLIESRLQQTAKPGDAPMESAKEREAGGLGTKTPGTSRRKAPPGLSIVAPSHEQFAHERVIQSAPLNQSFTGRHQPHPLTRHVANQNSNLSSTSHIHHIPATQTSNRLPPISDVFATEGLGAHRGFPNASASNSSHSNSRPTFPSPSQQPHTARPREYRSAEEAQAELSGGRPELLPKIVHYGGHQPPTPPSPLTGNPMRQTDTNRSGSGRRRARAEYEEGASPPLGHGPSAQRRGPFGEGRDSPRSQQAKKDEFISLCARAWDLFHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCS1</accession>
    <name>A0A3D8RCS1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_07804</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5335210at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="420"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="642"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="742"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="808"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="867"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="758"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="870"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="904"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1106"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1177"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1211"/>
            <end position="1234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1270"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1305"/>
            <end position="1315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1318"/>
            <end position="1329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1330"/>
            <end position="1342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW71770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1349" mass="145917" checksum="CA722193C099C33B" modified="2019-01-16" version="1">MNRFRTKKKAKETGDIAARPSTDSDGSGILPIKTSKTWGRTRKTQEPEPKPELDLSTALPSSDDFRTSLLMSGLSARFSMLREQDDPNSKLGKASDDSVLFPSNRQSRLNDFGYFGRGGLSDIAEVSSISGSIKPPFAAMNRKDSYNTLDGYGTDDDSNNGGSIMSRAKPGEGNNLFGGRQKIYKIAGGATSTKSMGEGGSLGGKILYDDDVAQSAFQKLRERERAEERMRKAHEEQECEEAEQRVEDSRPSSPPLTGYNRNRETSSTTSSGPNARMSTAATSVTSQRTPSLKGHNTSVPGTPALNTSGLERSGTKGRRLYETGLDKDLHEQQFSAMSRIDTLARQRTLGAHTPPPGLASPTSATSTGAFDRFDRQPVATQSSMPNLRAASPPPIPAAAAKFDFGIKPAALEPKSIASFASPALSPPLSPPMSEDDNGQFPVQPADIGKATASLAFSKPVQPYDDNKYSQRQIQMQQGREDQPLRKHSPPEAFAPRQQPSVPRTRADSSATLNSGASVRPGPNSLAQRTGPMHERFATKPISEIKVPENHAITAAGTFLTSPDAPSSPDDFDMPPSKPWDRAGAQSPSIPKGYRPDPSQSPILECPPESQHPANRELAPASSPIEVPLVDRVDMIMGNVNPIRLSTGDLSKIRPKSPRTEDSPTLGPTTGLSGMVRQHLRSDSNNSSIYGVQSAAPSAAFASRFPQDHTELVPQHDYSSTKSNPWDLDDWDQQYQGENKENNLYGQVSAPAPLTVKSARTETSVEEKPAWEQELANHHARMGSTETQIERQELADDLAFRRKQVQEKMKSFVETDSRSNSPLPGMDWARQNNPLGILKAKTSRTSLSVKTQREKEPVPTKTMKMLGLGNATMNSSPSPNSKVFEEDPWKQEEEEMLRGVPKPRGGSETKAFRQARRDAQRTREQDNMRYGPAQGRRPSAEREWTAPLAIQTRGLPRQNDPNRERGPAPMHTGPRMGAPGQERGPMQMGPRVRAPSRDRHPPPVSQNPRRQNGSSRDSHDSESSSRTGSRPPSRDRSGSDASGGRSKSRNGRYRDDIAKAMGDGMGSSAAHNGYEAAPVSARSMPKSPAQPGLNYQPSHSPAFLPSPSFPVSPAMPSPAPGPDAPFRARSRTNSKAGYFDQSLAPGQSSEEIGLSPRPSPVAPFVVNPTPPIEHPSPLMSSTTPTGAGFQSNGRITAARKKSINKSDISEPTLISSTSRITTVNLPPGSSLSNGAEPSPPIPPINPRRRQTRVQTMFGAFASKKEDAMPSLSLQQATQSTDEMSTFSADEADKVPRHRQKLRKSSSEGGNLNSIARQQAMAMPSPAMPAATFPPPEGRSPSPPKVEGGMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RD20</accession>
    <name>A0A3D8RD20_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_07825</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RD20"/>
    <dbReference type="OrthoDB" id="413520at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF132">
        <property type="entry name" value="PROTEIN-LYSINE METHYLTRANSFERASE C42C1.13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW71791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="377" mass="41217" checksum="721C305CA1E4F408" modified="2019-01-16" version="1">MHYIRFLKQPRLLPSASAPNQVSAKITITTDLGESFCFETVPLCALLEIDASGSTSGGGAWKILASANIVWAAKDGYTGVEVIIPAPNLARLRHGRVRMVIKARSNALDVSAFENCWVQAAEETSGVVAVRSMEINVRPHADQRPAVQALAERVFHAHGKELHIWEEAGESIARHIWDAGLVLSSYLSFFSPLSSESGEVYSPPELLLLQTTLQKEEFQVLELGAGCGIVGISLATFFPEAKQVILTDLPEASEILTHNVSLLPSPTNFKVSHQVLDWSLPLPTNIQSTRWDLILVADCTYNPDVVPDLVKALGRLTEPGKAEALVVVAMKVRHESEAVFFDLMQDAGFVVKEKAKVPLEVLGADREEIEIFGFMRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RHZ9</accession>
    <name>A0A3D8RHZ9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_07117</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RHZ9"/>
    <dbReference type="OrthoDB" id="3366823at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11040">
        <property type="entry name" value="CYP7_CYP8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="482"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW73675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="549" mass="62295" checksum="EC74D7848C3E0B97" modified="2019-01-16" version="1">MTITNATSPLAMSSTYNLTPATSVTIAIFKYPSWVQNRLNGRSYWLLVLLSLAVAFLGSRLFARRSNSKEPDQIPYRLPLVGYAYQYVFHNAAFTDYVLSIMKGRSVMNFYLGPRLFYFVTGAKNAAAVVRHSGKLSADELFLYATTKVAAGTEADMQISRNDKSGRGEKPAVPVPEDQRIWHPHHRLHSDYLTTGRSVEVMTAKFCEFFQAKLARFSAEEWEVINLFEFLKKHMLESATASMSGTELLATNPDFTERFWRFDRSIFTLLFGGPRLLNRGSYQARDYYHQAAQKYLEEKKDFDFNDAAVDVDWEPTFGSRFTLNANAIPMATWAMVEILQDPELMAKLKKEIATATVPDSETKQKILDMENLKKLPLLQSIYVETLRLHVSVNVTREVVEDMEMDGYLLKKGGLVQTPSGVAHFDESVWGVPGHPATEFWAERHLVDVEEEDADGNIKITKQFSIGKKTSSFFPYGGGITVCPGRHFAKQEIMAAIALILSNFDIEFLDYVNKDGTVSDRAPKDDPYYYGAAAMPPDRDLRIRWKRLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RI22</accession>
    <name>A0A3D8RI22_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_07151</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RI22"/>
    <dbReference type="OrthoDB" id="10298840at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW73709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="26681" checksum="8214E8E75F4C7B38" modified="2019-01-16" version="1">MSSPVQVLFIPIAADCRVHEAGSEDANTWNEKFLSPLRETEGVEEVFWSRQLDNDENIGVVVFWASRPHLQAWQTRFSSSMLQLNPLIKASYKSYTLLLPAFTTVSPATEKQDLHRVLSQNITKLFIWYFPHSTAPPTNELQTTVSLGLGEFVRRNFVVGEVEEKGDGSEQMNAFGAWREEEDEAFGEKGRSFSGFVGLQSEDDFRKMPPFEANFEKRKGMTMRTFEFAKHGLGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RI63</accession>
    <name>A0A3D8RI63_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor TFIID subunit 12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_07175</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RI63"/>
    <dbReference type="OrthoDB" id="2193432at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07981">
        <property type="entry name" value="HFD_TAF12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000037">
        <property type="entry name" value="Transcription initiation factor TFIID subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037794">
        <property type="entry name" value="TAF12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003228">
        <property type="entry name" value="TFIID_TAF12_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12264:SF21">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03847">
        <property type="entry name" value="TFIID_20kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription initiation factor TFIID subunit 12" evidence="7">
        <location>
            <begin position="521"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="183"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="302"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="375"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="199"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="225"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="320"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="377"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="416"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="464"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW73733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="634" mass="67790" checksum="0E28D076856F3AE3" modified="2019-01-16" version="1">MNGAQGQPGQGQQSGAQPPQGQGQPQQHRVQLYKPENMRTLPEQFSAAEKQKWEQGLRVLWGTVEKNGPETQAHQDAKRKLYEFSKTLTQKIQQFRTQHAARLQQQGGGTAMQGVEAARAQGPKISQKVMDHINSFPYQPPSQYAQGSPEAAKWIQETKSRYLKGLLQMETSKGRMVALDAALEKRNNEGNPLNADEEKEWREKKEGAQKSYNEAQQFVEGFRKQQQAASQASNSAQQQANATASTNTNANPAQPSQAAPNPGAQSNAIGAGAGAQRPQMNLQQQNNIGQTVNAAIEAARNQQMGGGRPQMQAPNGQPSQNPVQGQAQTQGQAPGPTQNQPQAAPSMPNMPQGGPAPHIKTEAGIPAPINTAVAQVAAQQRSTPLQNNSPQSAIPQSAGPQSATSQGPPRPLTHQAALSQAARSYSSGQTTGTPNVMGMGTHAHPAGPGRETPNTITNKMPIPKHLPPNATAPPQPVAMPQPRPSFSGGPSNVGNGVMGQPVLTKPPGFQLDGDGDRVLNKKKLDELVKQITGGGDILGSGEGLTAETEESILNVADSFVDQVLQSACKNAKERGSNMLEIRDIQLTLERQYNIRIPGYASDEIRTVRKIQPAPNWISKMSAVQAAKVTRKDDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIG1</accession>
    <name>A0A3D8RIG1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_07277</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIG1"/>
    <dbReference type="OrthoDB" id="5210591at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW73835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="411" mass="45162" checksum="CEA818EA59AB299F" modified="2019-01-16" version="1">MAASATTSGAPRPPILTSLMYSLPIRRLREILSHINPQVTLGPVEEIPSTQLARLYALTMSDGRRLLLSYAPSLSVRLLRQEATLLSSEATLVQFITDEIREASLKQSPADQSRKPPSILWLATLVPKLLKHSSNNREMAYPYSIYEPTSGAPLSTLSVYMSVSERRLIDKQIGVLARVLASLVPPGHTFGTAGRVLSDPSATGLMMLEPTGSSAWPAAFNSLLEGILRDGEDMSVLLPYDAVRNHNRRLSWRLEAVATPRLIILGTCPDMNVMIERGEESSSGTTKLTGLRSWGQGYFGDPLLSSCWEDPSEGFLEGWNDGGEDLIEDPDNAGSRMLLYKCYTAIVSIVTEYYRPHAESSRRELEGRRKLTSALAELERIEAATAGLKRTRSASAEVGDSKRPKLEESET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIQ5</accession>
    <name>A0A3D8RIQ5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THUMP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_07278</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIQ5"/>
    <dbReference type="OrthoDB" id="367221at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11717">
        <property type="entry name" value="THUMP_THUMPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2300.10:FF:000001">
        <property type="entry name" value="THUMP domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2300.10">
        <property type="entry name" value="THUMP superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040183">
        <property type="entry name" value="THUMPD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452">
        <property type="entry name" value="THUMP DOMAIN CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452:SF10">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02926">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00981">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143437">
        <property type="entry name" value="THUMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="3">
        <location>
            <begin position="157"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW73836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="323" mass="35882" checksum="D9110440CCCF2367" modified="2019-01-16" version="1">MADKRKNQHHDSRDDNQRAAKRSKGGSGGKWQTPHQKSKFEGRAETSREIIEPGDSGIWATCAKNQERRARDELEAILSESAERIYGLNVDSIPDDGGEAVDDIEASIKREMASLANKDTSTKPFVPVQLDLACVLFFKTRSPVVPVDFVHKICEDAHAGSGHRRSKYLNRLTPMTLMARATEKGLDEVARTVLAEHFDLRKENGTSTEDTEKEGCSFAIRPTIRNHTSLKRDSVIKQIAELVGPRHKVNLTKPDKVILVEIYQTVCGMSVVGSDWEALKRFNIAELYPSRLSTKSAPVGQAETTMLGKGKTDEAEEAAKIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJB5</accession>
    <name>A0A3D8RJB5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_07574</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJB5"/>
    <dbReference type="OrthoDB" id="5429770at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DBAG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW74132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="486" mass="55008" checksum="DBAD1AE62C590313" modified="2019-01-16" version="1">MAPVLNLLGDNMMPSVDDLAIAAFIHDHVIGMDYNGETRGHMDGFVDIQRLQNLDTNLIHAMKAIGLASFSHFQKSPLLMRDAQKHYLHAIQYTNAAIRDPVDVKKDSTLTSIMMLGIFETMTGTNPKSLEAYQNHFNGAAAVVKLRGREQLATPAGRRMFIQVTTNLIMICMQREVPLPEHILKLTEEVNRTMPAMLRESSGWRVQQAMIAYAQLRADIRVKKTSDPLEILQKVIELDGILLDIFERTPEGWHYTTIYTDSDPEVVWNGKYHLYYDYWIANIWNGMRTTRILLNTTMRSILLDGFSAKPPTFTSPEYTAQYQISTDTVYQLQADILASVPQHMGYVEKFQSPKLAYDASRPSNPESIEKALSNFHFSIVSDEQRRAAKSCSPMPAIRASGGYFIMWPLWFVGIMGFASEEVREYSIRNLESLGNNMGIRHALLLADIVRLRNTTGKYDDDRLFQKPKVQKPQATPTVLAPAVAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RNV2</accession>
    <name>A0A3D8RNV2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">INO80 complex subunit B-like conserved region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_06506</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RNV2"/>
    <dbReference type="OrthoDB" id="2021186at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029523">
        <property type="entry name" value="INO80B/Ies2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006880">
        <property type="entry name" value="INO80B_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21561:SF12">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04795">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01406">
        <property type="entry name" value="PAPA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="INO80 complex subunit B-like conserved region" evidence="2">
        <location>
            <begin position="279"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW75685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="392" mass="42956" checksum="E31BDADD1A21DCC4" modified="2019-01-16" version="1">MSRPSRRSAGGADPMTPIASVSRGPPSSSSRSPQSMRLTVKLPAGKLREATRTSTGSIAVNSRDPFAGGEILEGRRARNVKKSYVLPESDEDEEDEEEEDDEMEDLGDEDAEGEEDDQEMDDVSDDDADGDIDMDIPPAPTIKVSKAQTGKQTIVVKPSGKSDGKSVERKEAEVSDDDEELSDIDSPAEEDDDDQQEVGDEDADGDEEDEEIVLEEEEDEENPFGSDDEDTPVAGSRGSTPDINKMTKRQRAKLEEGANDFLMALPDEVQVKKHLTAEEHAMRRAEMARRRKNLSEKRNEEEKMETINKLLKKQAPKTNARRRDFAGATTGDAIPEIEVVKPNPIFVRWVSGKDGNRIGVPEEWLDGPAGAIFGKSIKATGTLKAGSLVEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPE2</accession>
    <name>A0A3D8RPE2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ER-derived vesicle protein ERV15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_06740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cornichon family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPE2"/>
    <dbReference type="OrthoDB" id="434393at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003377">
        <property type="entry name" value="Cornichon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033466">
        <property type="entry name" value="Cornichon_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12290">
        <property type="entry name" value="CORNICHON-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03311">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01398">
        <property type="entry name" value="Cornichon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01340">
        <property type="entry name" value="CORNICHON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW75919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="138" mass="16094" checksum="1F75CAE6CEB292C4" modified="2019-01-16" version="1">MSGEAWLYLLAVLINAVNLFLQVFFTIMYSDLECDYINPIDLCNRLNTYIIPEAAVHGFLTFLFLINGYWVALLLNLPLLAFNAKKIFDNAHLLDATEIFRKLNVHKKESFIKLGFHLIMFFFYLYSMIVALIRDESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPK3</accession>
    <name>A0A3D8RPK3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_06814</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPK3"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF4">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="111"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="494"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW75993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="609" mass="67984" checksum="6A468C7C6A92B0E0" modified="2019-01-16" version="1">MASQLQIHDLNTPAILSIVPNPPSNNRIVILIDDMENQQNKLTPDEMIEVLVSRPASLPATMPPLGRDGAFLLQLFMVQSKMKAAKQKADEAEALRPLYETSEYNLTHPNRDILYKQVNIPGCGKGLVAKQVIARGTMIIMDLPLLRLKTAPCDNSYTTDEGEKAYLAENQEIAKQVKEMGKHEQRTFLLLPKYDKSKKAPFIGIVNANALPVEPTGVAVFPEISKLNHACAPTAEYSFNTTTGEARVYAVQHIEPGQEITIDYTLYRWDHELRRTGLTNCFGFFCKCDYICGTTDAGLQAHKQMWNHFASLDQYLVPETAGFMLKFGEEAMNNMYTRKNMCQMMNIWDSRAAGTFFHAWQICLAHRDLQRAQCFGVRALVNFRDCLGEEHLTVKIMQQRLKEYASEAIFEKESYWKGTTPEDENFDTSGLTAKEFHDWLWYPGLLKLMLTPDGTPGSALAWWTVANIPWRHNYPELTEADFDFFHLLPTGEAETGENELEGSTARSYSPRPASTVEGSEATLVDAENEEERLAEDIAVLEVSGGGDKDSDVGPAAHGGAIDLVQTEKDLEYQVTAREDGNIAVADTKLGNLMAEGDAKGAGLHVNENE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPM3</accession>
    <name>A0A3D8RPM3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_06741</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPM3"/>
    <dbReference type="OrthoDB" id="10257301at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000191">
        <property type="entry name" value="mRNA splicing factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032847">
        <property type="entry name" value="PRPF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="231"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="275"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="361"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="494"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="76"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW75920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="527" mass="59654" checksum="52818814E736C638" modified="2019-01-16" version="1">MAEFNTYPPNMAPQNALIVRQAEGQDHAVVPYTEEVLSRTLQGPANPFKDEVNSLKRKNVLTGYAEETFLSEHTFRSQHRAVERRGGPDGELLSGKAAKEESARIRAKRQKKGDATVADGENSYVGPWAKYKQQEYESYEEGDELASDEEYEEVEEEVIESGAVVPALPDALAKRKEVEELGEETTTFHGSEQYDYQGRTYMHVPQDLDIDLRQEPGSVKNYVPKKLVHTWKSHTKQIAGLRFFPGSGHLLLSGSADNTVKIWDVYHQRELLRTYSGHTKALSDITFNATGTQFLSASYDRMIKLWDTETGQCLNRFTTGKTPHVIKFNPSPEHSNEFLAGMSDKKIIQFDIRTREIVQEYDHHLAAINTITFVDENRRFMTTSDDKSLRAWEYNIPVPIKYIAEPYMYPMTRASAHPSGKYVAYQSSDNQIVVYGANDKFRQNRKKGFRGHNNAGYAIDVACSPDGQFVASGDSGGFVCFWDWKTSKMWHKMQAGHGGAVTCVEWHPQETSKVVTAGLDGTIKYWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVD4</accession>
    <name>A0A3D8RVD4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-L-rhamnosidase</fullName>
            <ecNumber evidence="2">3.2.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_05884</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides.</text>
            <dbReference type="EC" id="3.2.1.40"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.40" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVD4"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030596">
        <property type="term" value="F:alpha-L-rhamnosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.420.10">
        <property type="entry name" value="Maltose phosphorylase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016007">
        <property type="entry name" value="Alpha_rhamnosid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035396">
        <property type="entry name" value="Bac_rhamnosid6H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035398">
        <property type="entry name" value="Bac_rhamnosid_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013737">
        <property type="entry name" value="Bac_rhamnosid_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008902">
        <property type="entry name" value="Rhamnosid_concanavalin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33307">
        <property type="entry name" value="ALPHA-RHAMNOSIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33307:SF6">
        <property type="entry name" value="ALPHA-RHAMNOSIDASE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05592">
        <property type="entry name" value="Bac_rhamnosid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17389">
        <property type="entry name" value="Bac_rhamnosid6H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17390">
        <property type="entry name" value="Bac_rhamnosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08531">
        <property type="entry name" value="Bac_rhamnosid_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25788">
        <property type="entry name" value="Ig_Rha78A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010631">
        <property type="entry name" value="A-rhamnsds"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacterial alpha-L-rhamnosidase N-terminal" evidence="5">
        <location>
            <begin position="149"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase concanavalin-like" evidence="4">
        <location>
            <begin position="338"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase six-hairpin glycosidase" evidence="6">
        <location>
            <begin position="446"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-rhamnosidase C-terminal" evidence="7">
        <location>
            <begin position="798"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW78032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="915" mass="102508" checksum="F3CB766BB3356CA5" modified="2019-01-16" version="1">MSLGLPKIAAPTFEQHHDGLGIGNARPRLSWRFTSIAKDWKQSGYDLEVRRKDGKTESYHVEGSQSVLAPWPSQPLESREQASVRVRSFQDGSEGMATEWSDWAVVEAGLLNKEDWTAELISAAATAHDDGPLRPVRLRKTFTIPPKRDIQKSRLYITCLGIYEAYINGVRVGDHVMAPGWTSYHHRLNYQTFDVAPLLREGENVLAVEIAEGWYATRLLWREGRRYTYGKDLALLSQLEISFGDDDKTMTIPSDTTWKRHDSAILRSELYDGEVYDMREETEDWYLPDSTGATKTDAVNSWTNVTFATFPQKTKLVASDAPPVRVIEDVAPVNIFKSPAGKTLIDFGQNLVGRVYVTSLKKPAGHKVIFQHAEVLENEELGIRPLRCAKAFNTVISSGTELKDWSPHFTFQGFRYMQVDGWSPEDESDPLTKEKIKVQLLHTDLKRTGWFSCSNEKVNKLHNNALWSMRGNFLSIPTDCPQRDERLGWTGDIQVFGPSAGFLYNTTGMLGNWLEDLSVDQEDANSIPPVVIPNVLKDDWKDTPQAAWCDVTVLLPWTLYKSSQDAEILRRQYPSMVSWLKKGLPRGSDGLWESNHWKLGDWLDPAAPPDAPDKCLTDATLVADAYLVYVTGIVSEICTIIGLVDDHKMWAADYAKVKETFQRKYITPSGLVMSDTQTAYALALVFSLYENKSQVSYAAQRLARLVRIAAFRVSCGFVGTPLITHALSKTANPILAYRMLLEEGCPSWLYPVSMGATTMWERWDSMLPDGTINPGSMTSFNHYALGSVVNWLHEVVAGISPLEPGWKKILVRPVPGGDLTTAEARFEGPYGEVKSSWVVESGVFMLSLVIPPNSSAWVVMPDKQITDAGSVEEETGLEIGSGKHAFTCKWENVGWPPKALYVGWPAMRPDSDDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVJ5</accession>
    <name>A0A3D8RVJ5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoglycerate mutase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_05867</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVJ5"/>
    <dbReference type="OrthoDB" id="425925at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07040">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW78015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="20657" checksum="F6E335E09AB33AFC" modified="2019-01-16" version="1">MVAKPIIYLIRHGEKPPKKDGKDVDGLSSEGVKRADYLPQVFGKQSQYSIGYILAEHPEKVHLDGSRDRPYETVLPLSKALDLPIHKHISRDDVGDAAKKALAYQGPGNVLICWEHGELAKIAQALGVTGFTGRPDCKVVYPDDRFDLIWTVSEPYTEISQVASEDVPGLDGGAVKDWCVCEEKKSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVN4</accession>
    <name>A0A3D8RVN4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_05981</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVN4"/>
    <dbReference type="OrthoDB" id="1937934at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22439">
        <property type="entry name" value="KH-I_PCBP_rpt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22455">
        <property type="entry name" value="KH-I_Rnc1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22456">
        <property type="entry name" value="KH-I_Rnc1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="112"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="195"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="392"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="303"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="58"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW78129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="468" mass="48780" checksum="3E2A3B75D208EBFA" modified="2019-01-16" version="1">MSASPVAAVPTQSTKRPLEDPSSPSAPTDQPDAKRPALDKIVKGESESEEKVAEPAANGTNGEAKTEINGTTPATKDEQGDTVVTDATQSIESTGSRGQTSSGSTLHHDETAWIHIRAVITSAEAATVIGKGGENVSMIRKMSGAKCTVSDYQKGAVERILTVSGVVDAAAKAFGLIIRTLNNEALEAPSTTQSKTYPLRLLIPHILIGSIIGKGGVRIREIQEASGARLNASDSCLPLSTERSLVVLGVADAVHIATYYVGSTLFEQLSERFGGPAASAYASRSGGPAGVVPGGMQVVPYVPQPAGGNYGHPDNYRRHDRGAHSTPAQGYGQPYATPAQAQPAQVPMHYGGQPAAGGYGGVGPAQPHQPGPAVPQHGGPPAQPMQGMVPGQPLTQQIFIPNDMVGAIIGKGGAKINEIRQLSGSVIKINEPQDNSNERLVTITGTAECNQMALYMLYSRLESEKHRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVR6</accession>
    <name>A0A3D8RVR6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_05753</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW77901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVR6"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF6">
        <property type="entry name" value="MONOOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G15050)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW77901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="600" mass="67164" checksum="B9DD60A4FEF86EE7" modified="2019-01-16" version="1">MAPSLEIVDNTSGVPGVVGVQNTKNIISVASSGIPLEPSSTEFELEDHPIDEIHPVKVAVIGAGLSGITAGALIPVKVPGVNLQILEKNPDVGGTWFENAFPGVRCDIPANVYQSTFEPNTQWSEEYAQGAEIRDYWQSVARKHNVYQYLRLSHNVESAAWDESTAQWKLSVQNTVTNEAFEESFDVLMTAIGRFNAWKLPEYPGIEEFEGHLRHSSAWDTDFDPKGKVVAVIGNGASGIQVVPNIQPLVQRLDHYARSKTWIAGSFGGEGAGRTLEPRYYAPELLKSFEDPKTYLLFRKELEDKFYRRFSTLFRDTEENEKLKEEFKALMAERLKKKPELLEHMIPDFSPNCRRLTPGPGYLEALTEDNVNYITTPIQRFTKDGIVTQDGVERKVDAVICSTGANVDGLPPFPITANGQDIRDVWKPSPYTYLGLATPSFPNLLFIQGPNAIGHSGTVPNSVETQITYISQLLRKVQQQRIKTFVPSKAAADDFSAYCDAFFPKTVFTENCSSWANGGKPGGKIHGHWPGSASHLNHVRRSPRWEDWEWSSRGKTGNRFAYFGNGWTSKEKAGEGDLTAYLKLPQEIDLRKYHEEWFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVX8</accession>
    <name>A0A3D8RVX8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Probable endonuclease LCL3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Probable endonuclease lcl3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BP5796_06007</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the LCL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVX8"/>
    <dbReference type="OrthoDB" id="430293at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.90:FF:000029">
        <property type="entry name" value="Probable endonuclease lcl3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035437">
        <property type="entry name" value="SNase_OB-fold_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016071">
        <property type="entry name" value="Staphylococal_nuclease_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302">
        <property type="entry name" value="EBNA2 BINDING PROTEIN P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12302:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00565">
        <property type="entry name" value="SNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00318">
        <property type="entry name" value="SNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50199">
        <property type="entry name" value="Staphylococcal nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50830">
        <property type="entry name" value="TNASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0106">Calcium</keyword>
    <keyword evidence="9 17" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="TNase-like" evidence="16">
        <location>
            <begin position="80"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="251"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDW78155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="260" mass="30473" checksum="B17DDA3FF418C68B" modified="2019-01-16" version="1">MRWPLWSSNSDRDHERDDRKPVSWADSLQATDWQHYTDPRTVVPTILLTTTILVSVRVYRAYIRRIPEATYIRPSAFRKRSLFGQVTRVGDGDNFHLFHTPGGRLTGWGWLPWRKIPERKADLKGKTIQVRIAGIDAPEGAHFGKTAQPFSDEALTWLKNYILNRRVRAYIYKRDQYERVVATVWVRRFLLRKDVGLEMLKAGYATVYEANTGAEFGDFEEKYRRVELKAKKKRLGMWSGNSKDYESPREYKRRTAAGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RW11</accession>
    <name>A0A3D8RW11_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">5-oxoprolinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_06111</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049517">
        <property type="entry name" value="ACX-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF9">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19278">
        <property type="entry name" value="Hydant_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="4">
        <location>
            <begin position="15"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="2">
        <location>
            <begin position="246"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Acetophenone carboxylase-like C-terminal" evidence="5">
        <location>
            <begin position="663"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="3">
        <location>
            <begin position="742"/>
            <end position="1279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW78259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1283" mass="138550" checksum="C5770C2AA0F9BCD3" modified="2019-01-16" version="1">MPHRSSSPRPAGILIAIDRGGTFTDFWAKIPGRQNPMVFKLLSVCPDVYPDAPTEGVRRILEEATGTSIPKDQPLDISLVESIRMGTTVATNALLERQGEPVALLITKGMLDLLIIGNQARPHIFDLTVKKLDKLYEKVIEVDERVTIEGFSEDPEPKPINAADDPDLVEGLSGEVVRILTKPNYDNVRKDLQALWDEGYRSLAIALMHSYAYPTHELEIAQIAKEMGFKISVSCELQPMIKIIPRAQSATADAYLSPVIQRYLEGFAKGFLGEFKDEKSSKKLLLSQSDGSLTTFSTFTGLRAVLSGPAGGVVGMARTCFDEVSQVPVLGFDMGGTSTDVSRYGGSYEHVFESTIAEVTIQSPQLDISTVAAGGGSMLFWRNGLFVVGPESAGAFPGPACYGKSGPLTVTDANLFLGRLVADFFPSKLDLDVVKSKFAALTDEVNLDRAGLPKMTPEEVANGFLSVANAAMARPIRNLSEGRGFDTSAHNLACFGGAGGQHATAVARDLGLKRVLIHRLSSILSAYGMALADIEVDLQEPESVSFNEGTQPRLESRMETIKGKASAKLASQGFGEAQITHNYFLNMRYKGSDTSLMVQGAGKDTDFGAAFTKRHMREFGFTQPREILVDDIRVRSVGRSMNLEKLGGLEIPEDLSKLEYAGKDKSAYTRQVYFEGSGWVDTHVFHLDNLPVTHKVSGPAIVIDPTQTIVIDPASEAIILPQHVIIDLLDSKSQFISSEVVNPIHLSVFGHRFMSIAEQMGTTFQKTSISTNIKERLDFSCAIFSSDGGLVANAPHIPGHLGSMAYAIAYQANKYPKGQLKPGDVLLSNHPIAGGTHLPDLTVTTPVFDDDENPQEILFFAANRGHHADIGGIAAGSMPPNSTELWQEGAAIESFKLVKEGEFDEDGVTELLYDIPGSYPGCSGTRCLKDNIADLKAAIAANKRGISLLSAMIREYTWPVVKLYMAAIQKNAEDSVRDLLKKFSVRFHGQPLEAVDYLDDGTPLAVKISIDGETGSAKFDFTGTGPETFNNLNAPPAVMYSGIMYCLRSMISTDIPLNQGCLQPIEVYCPPDTVLSPSLKAATVGSNVETSQRIIDLIFKAFRAAAASQGSMNNLTFGYGGTDSAGNVTKGFGYYETIAGGAGAGDDWQGQDGVHTNATNTRMTDPEVFEKRYPVILREFSIRKGSGGKGRNRGGDGCIRDIEIRRPMQVSILSERRVIAPYGMAGGEEGKRGVNIWIRNDPLDGSIRTISLGGKASVMMIPGDRIIVNTPGGGGYGVPEVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWG0</accession>
    <name>A0A3D8RWG0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative apsB protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_06168</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255000at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024545">
        <property type="entry name" value="Mto1-like_Mto2p-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF80">
        <property type="entry name" value="GRIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12808">
        <property type="entry name" value="Mto2_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomin N-terminal motif 1" evidence="5">
        <location>
            <begin position="467"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Mto1-like Mto2p-binding" evidence="6">
        <location>
            <begin position="1439"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="60"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="440"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="536"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="683"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="782"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1175"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1374"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1455"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="634"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="708"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="808"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="232"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="264"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="345"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="443"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="536"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="550"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="689"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="789"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1189"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1389"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1406"/>
            <end position="1419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW78316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1498" mass="168995" checksum="A0895C8E0216C7AD" modified="2019-01-16" version="1">MAEEEEHSDMAAEERPQTALKDSRKIPGGFGADDVDDLSPTKMEFEDSIFTNAKAVAQNNRMPSLGHGSLPSLPPPHDSSLLYNHSENDELMELDEKEMQRHLNDVESSFLPALSPIAPARPGGDDTYLSDSEPQEVKGRLSSIAEVNTPNKNTDEDLPNHGRKSPPTPDNAYQTPGVTRPGSPDPEHSSLDEDGNTTSALETMSSSPTAAAAARTISRAVSAASTGRGYEPADDTAEENLEPEDLEATPRRPRNVLQPDADSSDGQSTVRHHASSQSLADAGSTPGHGLLPSRSRRPKFLKSRHASQRSSQSSFITNPDSQDEDNNYGADYALQSGGAVPGHGTSRTSSAGLSRSVSLGSMASGVDDSGNESAYQGHDRSLATLTEEERNRERKMDDDEPAAPETPRANSRTLAAPTDTIIARHVRNVHVPESLVKEYRNKSGVSSPNKRSSFSATSLGKSGRNLTLKEQSSTIERLSKENFDLKLKVMFLSDRLDKLSEEGVKEMISENVELKTGLAVMQRDNKALRRKIKELEKQLKENEGRPDTARSGTSTEDQSPQWFDQEGAQEREEELIYLRERVEEYATEIEKLRKEGITRENEKRNLAEVVRNIGERQGQNLDAREEMDVWKDLLEQETARREQSDEDNKKLRDEIFRLKTEVSANGMPGLNHTTNIYNITKKRTMSPSRESRPGSELSGRIDDRNGAFSQASTLADELRREAEQLRHENAELRREVGAQTSMLTSRRREKELLYQEIEDLKLGQRRAGGSVAGESIFERSASRAGAHVRSSSRMSAATRQTGLSDAEREEYENKNAELRDKMNSLKLQSQELERELDSCMADFEMAAEQKKNAEVLVEELQEALDVAESDLLTMQTDRDEALQGQEEAENMFDALRKEAQEELDGFAAEMDEANQEIERLHGEVTDTTENFNALQNEMRSMSEALVRLEDDQETHLKRIQELEKELEEANKELEQMETNLVEANGKINRLTVQQESSQGEITFLREEQDNDKIKMGDMEAAIRNLEQNLQEERSRGKELEQRLEDERHQRDVVAAEEKEEVQAFVNDLNREASDAKDEARRLRKILTSKEVEAAEWKERLTELESNLREALGDLGGTRSSFLKSIAKLQRELENTIRDFDSTKASLAEKERIIKQRDALLESHGLESRKLAEMLDKERQSHRTTKHTFETYQKTQQHTSRTLTQQESRVLELETSRAQDRKKMAQLEATFKEQLTERNNVLLNMWNRLSALCGTDWTHNNSLINGRALPSLEAVSTMLPGFSKNLLGAVKHLESIITNFKSQIRTVERDLWKEYQNLEYNLDVRSKRIDRLEVMTKSGIPIFTDGKAEITKLRDVNKSLKTEVSSLRAAMEVQSRAYEEHGSPAPSIPTGPRTTGSRSRTSDKSRASTMTRHSSNTTAETIERLTTAGAADEEYKPDLRWQVRLQELEYKLKAEREARKLDRSSARQRLEEKSRENAELAAELERERIREEMRNASPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWG2</accession>
    <name>A0A3D8RWG2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Phosphoglycerate mutase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_06245</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWG2"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF32">
        <property type="entry name" value="ANCHORED PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017541755" description="Phosphoglycerate mutase-like protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="729"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="778"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="730"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="778"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="822"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="836"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="853"/>
            <end position="865"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW78393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="892" mass="91559" checksum="4427276B28ABDF91" modified="2019-01-16" version="1">MSRSMLAWAATALSLLSSVEASYLQYSTVDGFFLQDVSSTDASTFDYTSTNFGLINQTYSTDAAFDPSGTKTQWERFENYVNLLNSQTNSSTNYKILYIGRHGEGWHNVGAKNENPEQITNLLAWTDGDAAWNCYWSELDGNGTIVWADAHITPNGIAQAQIANTFWTSQIANQKQSLPQSYYTSPLSRCLETVNITFSGLTEQVPTVKELFREGISMHTCDRRSNKTYIHDSFPTYDIEAGFTEDDELWKGFEGETSAAQDARSKTVLDEVFSTDSNTFLSITTHSGEGASLLRVLGHRTFSLVTGAVIPVLVEARVISGSATTTSFSSWSAAATCTQPPLSTLTNGACVCPSGTASSTVLSTSPASINATITSTSSLPTGTGVTGSSGISSSAVYTNSTRSVSCSKKSTSAPSATSCPVALVTKVVYTTGKSTVTLCAKCSASALCPPESTKTYTTTAEVTTAVCPVSTSVLSANGTSILPTGPVSTTLPMSISSIKPSSNATVPTASKKSCSKSHSISSSALVSASTASATKLTTSTVTTTDVVTISKCAPTVTDCPYTTSPVVSTTVYSYTTVCPVTETEAASSSITTKAAPSVTSAELTTSSATSTKLTTSTVTTTDVITISKCAPTVTDCPYTTTPVVSTIVYSYTTVCPVTETESVSSGITTKSALSATSAKLTTSTVVTTEIITISQCASTVTNCPFTTSPVLSSTVYSYTTVCPVTEIEASPSGTSTKGASSASSPVQTGATSAVVTETVVPVSPSEITQVISVKTTATSEAASSVGSASTTGAPSASSPAEASSGSKSATGATSAKTGSSSPPYTAGNSTTAIHVSGSGISTHSSMISTSTTRVSESAAPTQTQNVVSTGGASKMESGLAAAVGLAFAVLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWL6</accession>
    <name>A0A3D8RWL6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative benomyl resistance protein-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_06053</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWL6"/>
    <dbReference type="OrthoDB" id="3365399at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF12">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06440)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="343"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="482"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="517"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="113"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="554"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="30"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="554"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="589"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW78201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="607" mass="66511" checksum="7E03A41BEE3730DC" modified="2019-01-16" version="1">MAEEKELGMLSTSRPATLTSFAEVDKEQHSPSSPTRTTSSDVSSLHDSINSDPLSALERALTPDLRIGAELTYTRTGTSFATNASRPPDFEVDFTTDDPDDPRNYPFWYKGVIVAAVSFATWTVVLYSTSYTSSMPGMMEEFGVTSEPVATLGVTMYLTGLAAGSLILAPLSEIYGRRPIYIGSLLVFCLLVLPCALATSLPEILVVRFFGAMCGSAMIANSPGTVADITNETYRALAFSIWSIGPMNGPVTGPLIGGFAAEYLGWRWTNWIVLILSGVGWAACSCLKETYAPAILKKKAAKMRKDTGDDRWWCRYDQQKLSIGEILKVNLSRPFVLTFTEPILWFWDAYIATIYGILYLCFVAYPLIYQGLRGWSAGFTGLAFLGIGVGTMLAIVSEPLVRRMIQAHEKEPETGRVAPEASVSIVCIAAILIPVGQLWFSWTSVPITIHWIWPILSGIPFGAGNSLVFIYSSNYLASTYGIYSASALAGNSVIRSFVGGTLPLAGPAMYAAMTPQWAGTMLGLLEVALIPIPFVFYKWGKQIRMRSPLIKRLREDQERSEKRAARARRHAARHNGDVRMAEEGGVVETGDHEKLDRSITGERDVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWQ6</accession>
    <name>A0A3D8RWQ6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_06335</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWQ6"/>
    <dbReference type="OrthoDB" id="5396721at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003739">
        <property type="entry name" value="Lys_aminomutase/Glu_NH3_mut"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00238">
        <property type="entry name" value="KamA family radical SAM protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30538:SF0">
        <property type="entry name" value="L-LYSINE 2,3-AMINOMUTASE AQ_1632-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30538">
        <property type="entry name" value="LYSINE 2,3-AMINOMUTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01070">
        <property type="entry name" value="PLP-dependent"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="8">
        <location>
            <begin position="270"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW78483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="561" mass="63275" checksum="EC7CFE4F96C011FC" modified="2019-01-16" version="1">MLSIPRTYVAFSYRPTPTVSKQSSKLICNARLISLNHFKQTAMAAGFKPRVEVNEPDLLKTTQQACEEQAKAKLHQLLHPRSAPILSSDGALLPKRAFDSLSSTSTHLSPGEIIQRVIPDITKATQTLTSSHHERYWRHIPSWKDVPEEVWLSHKWQLRNDIKGEKRLKAFLHEVLPVSIPPSITDTCCLKHIKTAQDFITEVELGIKHASMTIRLTPHMLSIINWANPLNDPILRQCIPLKSRLLPNHPKLTLDSLHETEDSPVGGLVHRYPDKVLFLSTDVCPFYCSYCTRSYAIGTNTDLVKKVSFKPTLDRWKDMILYIANNPQVQDVVVSGGDTYILTSDQIQWIGEQLLQIPHIKRFRFATKGLAVSPCRILDPTDAWAEEIIRLTWKGRALGKAVAVHTHFNHPSEFTWINRVAAQRLFASGVVLRNQSVLLKGVNDNVATMSHLIRELADNNIQPYYVYQHDMVKHVEHLRTPLQTILDLETQIRGSIAGFMMPNFVVDLPGGGGKRLASSYKSYDPLTGISTFVAPAVSGRGKEDRIYEYYDPIPNSDPAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2A2</accession>
    <name>A0A3D8S2A2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_05107</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2A2"/>
    <dbReference type="OrthoDB" id="4841025at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW80409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="295" mass="33511" checksum="0CDEDDADFA8EE9FC" modified="2019-01-16" version="1">MPRHIIEFFWKPGHSWSPTERLQVSEELRSIARECFGSVPEYQCLAKTEAAFNDKLVVIARERTTRKAIAFTSAILLHVDGVEAQTIVHTGLTCILPQNQGQGLTHLLFGELALHLFDEFKYGIWFSNLAAVPSSLVNVGKSARDPFPFHKACAPHPVHIHIAQMISENYRSDMNVSEHAVFDYQTFVMKDAKNSESPMLKDPKDPKIQHRDVTMNGFYHKLLEGKGSEVLQIGFWDPIYIHPALAWKTKDWRHIQILLKNQPAYLVHRFGLRALALVLVLLLFGILSLLKPKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2W7</accession>
    <name>A0A3D8S2W7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Family c-likeg-protein-coupled receptor protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_05340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2W7"/>
    <dbReference type="OrthoDB" id="3357002at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021460">
        <property type="entry name" value="DUF3112"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35184:SF1">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35184">
        <property type="entry name" value="YALI0C10208P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11309">
        <property type="entry name" value="DUF3112"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="276"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="352"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW80642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="43397" checksum="70E274396A393669" modified="2019-01-16" version="1">MGGPYMSQNAGLGGRPTKTLDDPITAVFLALFVCGAATHMTILQVNLHRGKKFIMSGLIFGFCMARIVTCTMRLVWASYPTDIPIAIAANIFVAAGVILLFIINLLFAQRIVRAQYSWFGWTKWFSILFKLLYASVIASLIAIITVTVQSFYTLDKNILRIDFDVQHVISTYFAFISFLPIPLIVLRLIVPKKTPTEKFGEGRFRTKVGVVLFCAILLCLGASFRAGTGYVPRPVKNPAWYHSKACFYVFNFTIEIIVVFTYAALRVDKRFHVPNGSHGPGDYSRDQGMAHRKSLSDRVNNEEQVFDEQDVIIAGDAEKGKEKDLEAGPAVPAQHQEPATEKTGEAAQGSDLSLASSTAASAQHQELNAEMTSEAAQDKGDESMEANTVPSTQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S384</accession>
    <name>A0A3D8S384_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetratricopeptide repeat protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_05232</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S384"/>
    <dbReference type="OrthoDB" id="1872379at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052769">
        <property type="entry name" value="TPR_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46014:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW80534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29553" checksum="51C054CF6B6DE4D6" modified="2019-01-16" version="1">MTSRTERFERKPRSPQKNEEPVEVIRFSPEEEASLLSESNAQKTSANELFVKSQYKDAIDAYGQALSTCPNYLDYEIAVLKSNVAACHLKLEDWKEAIKAATAAIDGLDRMKEKGEEGEKPQEEEEADEEIISAGAAKAEDVSVKGQREKDIERIRAKALMRRARARSEQGGWASLSGAEEDYKILEKMDNLSAADRKLVRQQLLKLPPRTKAAQEKEMGDMMGKLKDLGNGILKPFGLSTENFNMVKDEKTGGYSMNFNQGGPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S9D6</accession>
    <name>A0A3D8S9D6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ARF superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_04384</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW82893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S9D6"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04149">
        <property type="entry name" value="Arf6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000832">
        <property type="entry name" value="ADP-ribosylation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041838">
        <property type="entry name" value="Arf6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW82893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="189" mass="21125" checksum="672D995FB62E5803" modified="2019-01-16" version="1">MGGQISKMMGKIFGSKEMRLLMLGLDAAGKTTILYKLKLNQDVTTIPTVGFNVETVTYKNVKFNVWDVGGQDKIRPLWRHYFSGTQGLIFVIDSSDRDRIEEAKQELHRIINDREMKESLLLVFANKQDVAGAMKPQEVTDKLQLTKLKDKIWFVVPSCATTGEGLLEGLAWLSNNVKSPPAGGIPVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S9V6</accession>
    <name>A0A3D8S9V6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">MED10</name>
        <name evidence="10" type="ORF">BP5796_04633</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S9V6"/>
    <dbReference type="OrthoDB" id="337270at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019145">
        <property type="entry name" value="Mediator_Med10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13345">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13345:SF13">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09748">
        <property type="entry name" value="Med10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW83142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="153" mass="17522" checksum="3E84DE80034F518A" modified="2019-01-16" version="1">MAPDRIDEKVVENQIKDVIQDLYQVMVQVTAYDLTSRPSKDVLENSTIQLQHSLQKIHNTANSPTAQATMPSVPPELIQYVDTGRNPDIYTREFVERTRKMNQTMKGKFGAFSDFRDVLATEMARAMPELIEDIGLVVERTHGDKEKVMRNVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAU4</accession>
    <name>A0A3D8SAU4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative kinesin light chain 1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_04993</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAU4"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW83502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1187" mass="134129" checksum="39169E968DD75AC3" modified="2019-01-16" version="1">MACTKEKVKPTGLNVWSRGPEAGHVPVVDIIAVQGLGSHPYYTWVKKGQSSKASERQRFRDKAKFWKNKERQDKEQDGPAECMWIRDLLVPLFEDARIATYSYKSDWKDRNVKTNLRECAEQFLNTLHQHRQDKSALVLAVHQQDFTNIRLSVAGIIFLGAPFQGSDVATYGTWLARIADLDTALLEMLRKGSPDLHGISSDFYGSYNQWDVVCFYEKENSYMQTKVVNQQSARLLGKRAMFLETDHSGLNKFSGADDENFILVRSEIQRMVEDGPSSIIERYRINGIAETELYLHWRVPRVVNELFTGREELLDRIQKALRYDNNSFVKKQKRFVITGLGGQGKSEICLKIASLMQKEFWGVFWVNLDSPSTAENDFIAIANDLGHPVEHLAEALKVLANIRRSWLLILDNADDPKVDYQCYFPSGNNGAVMMTSRIPECRRYSPDASEALEGLDDEASDLLFKAAAIPPELWAPNYNSANEVVRCLGSHTLALIQAGAYIAKGHCQLHEYPGVFHRQRLRLLRYGPQQARSRYSDVFTTFEVSADILEQSEDETARDALHLLEIFSMVASSILPLRIFEAAWYEGKDIAYNNSTASSIDDLSQSHVSQLPSFMVIDGDEWDDYRLLEASSLLVSLSLITRHNQNDVPGISMHPLIHAWAKDRQSLKQQETVWMGTGCVLAFSQSDSEMWRTHARLLLPHIQSFLDIEVYTTLLIDSESIVLPILLNCGWALRDMRQDSRLGQLLERIFSKLRINPQKLCEDYLLLYKIQTENLYNLGKIKDTVLLQEQVVKIESVTLPKDHPDRLASQYELAKAYKANGQVKEAITLLEHVVKIQDAILAEDHPQRLASQHVLAMVYEANGQVKEAVTLLERVVQIESVTLAEDHPDRLASQHELAIAYEANGQVKEAITLLQRVVQIKSVTLAEDHPNRLASQHVLAMAYKANGQVKEAVTLLEHVVKIRDAKLAEDHPDRLASQHELARAYEANGQVKEAITLLQRVVQIESVTLAEDHPDRLASQHELAIAYKANGQVKEAITLLEQVVKIQDAILAEDHPQRLASQYVLAMAYEANGQVKEAVTLLERVVQIESVTLAEDHPNRLASQHELARAYKANGQVKEAVTLLEQVVKIQDAKLAEDHPQRLASQHVLARAYIANGQVKEAITLLEQVVKIQDAKLAEDYPQRLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SGH5</accession>
    <name>A0A3D8SGH5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_03770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SGH5"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="16"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW85445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="356" mass="37576" checksum="87ADB0DD90CCBC5C" modified="2019-01-16" version="1">MSVPDSFKAAILPAAGGQHIVSDRSQASLQPGEVGIKVTATAINPVDWKIRKYRVFLTEYPAVLGSDAAGEVVAVAPDVQDFAIGDRVFFQGIIGRYDYSTFQQYAKMPAALVAKTPSNISDDEAGGISLATVAVITAFYDETGNGLAAPWTKDGRKAGAGKAIVILGGSSSVGQYAIQFARLSGYDKIITNASPPHHDFLKGLGAHVVLDRSTTSSPENFKSAIGGLPLDFVFDAISIKDTQILGVKILQLTDTKNSHVVTVQGKDADAENSGESQEPKVQVKQVMGMGSNPALRYLVAPLWKHLGGEDGYIAKGEFKPNRPVVVSGGLNGLEDALDKSEKGVSGVKVIIRPHDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SGR3</accession>
    <name>A0A3D8SGR3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_03860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SGR3"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="97"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW85535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="339" mass="36463" checksum="BA352850A59918FF" modified="2019-01-16" version="1">MASPQPPYPLHPSVATKLDTVYVSFYNAHIFDKQQVHYQPVAASRTSGVLIPGGGPKLPVASTEDILIARTETEGPDVAVRVFTPEGEKPEAGWPVMIYYHGGGWVLGNIDTENTVCTNLCSRAACVVITVDYRLAPENPYPAAVHDSWEALVWVFRTGGARLGLDLSKAAVGGSSAGGNLAAIMCHKLLTHPPAGLAVAPKFLVQLLIVPVTDNTAAAATQPSWAENEFTAALPALKMLWYRKHYLPLESSWSEPEASPLLYPSGWAEQPPALIVVGELDVLRSEGEAYAQKLESAGVPVDLKIMKGMPHPFLAMDAVLQQGRDTITFMVEKLKAAFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SGV3</accession>
    <name>A0A3D8SGV3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytochrome P450-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_03848</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SGV3"/>
    <dbReference type="OrthoDB" id="3934656at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11060">
        <property type="entry name" value="CYP57A1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000050">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF232">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="316"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW85523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="545" mass="62207" checksum="2A3D64D5DE90ED85" modified="2019-01-16" version="1">MAAGTLVSTVLLHWPIVVAVALTAYFVGNYFNRGLNRYPGPFLASITDWWRFVDVYCKRPEATHIKLHEKYGDVVRLGPNTLSFASPKVLKSIYGLNKGFVKSEFYPVQQSVAGGRRFPSLFSTTSESFHQQLRRSVNSAFSMSTLVQYEPFVDSTTELFLEQTEKLYLKSNGKSCDFARWLQFYAFDVIGEMTYSKRHGFLEKNEDIEGIIEYISKLFNYVAPVGQIPWLDLVFLKNPLYLMLSTYGIVDATFPVSRFAQQRMAERLTPSATKAASDLSILPSTEPREKPVVTQPDLLSKFIQAKADRPEFMNDALVLTMAVSMAFAGSETTAISLSAVFYYLLKNPRCMEKLLKELDDKSREGYFHDTEKGHVTWTESQGLPYLDACIKEAFRLHPAPGLPMERVVPPEGAEIGGVFVKGGTIVGCNAWVLHRRREVFGEDVEVYRPERWLVDESKGQDVEEKRIKEMNGTMLQFGMGARTCIGKNISLLEIYKLVPTFLRRFEIQLEDPSQDWKLHNAWFVRQLNFRTTFQRRDMVHPASEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SH84</accession>
    <name>A0A3D8SH84_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_04032</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SH84"/>
    <dbReference type="OrthoDB" id="3897607at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF167">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="64"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="2"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="210"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="227"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW85707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="236" mass="26189" checksum="FF71E3F0E8B0212F" modified="2019-01-16" version="1">MPVYAAWDFQYLIDGTGKCYSTETYEMIAMINGTANIVTDFVFATLPLPLIIPLQMNPRKKISLIGVLSLGYFACAAAIVKCHLLSAFFSDADYSYNDSYMVWNDIELNAGILAACLPTLRPLFSCIFETTATMISQLSGSHGHSASQNHFYDQETRDMKLESVDSFSILTHPYGYWMADAADADLERGYKKANGPKSRLSKSIAEDYKEAVPETRDHSTPKEGITITVTNRSTTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHM7</accession>
    <name>A0A3D8SHM7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongation factor 1-alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">ERF-3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">ERF2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic peptide chain release factor GTP-binding subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Polypeptide release factor 3</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Translation release factor 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BP5796_03989</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHM7"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018444">
        <property type="term" value="C:translation release factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03704">
        <property type="entry name" value="eRF3_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04089">
        <property type="entry name" value="eRF3_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000017">
        <property type="entry name" value="Eukaryotic peptide chain release factor GTP-binding subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000503">
        <property type="entry name" value="Peptide chain release factor subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000061">
        <property type="entry name" value="Translation release factor eRF3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003285">
        <property type="entry name" value="Sup35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01343">
        <property type="entry name" value="YEASTERF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Tr-type G" evidence="16">
        <location>
            <begin position="276"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="64"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="227"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="249"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDW85664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="711" mass="77098" checksum="47BF32D69BC3988F" modified="2019-01-16" version="1">MSDLNSWEDDPAAQEDNLSRQTQQMNLNNQQPAASFRPGANSFQPGAQSFQPGQTFQQYGGGYDQQYNQNYYNQQAGGYGYPQYGQQQGGYQYQQGGYGGYNQQGGYNQQYAQQFPGYAQQPAAATSAATSQPPRPTPTIAKRPTDGSAGDLNKPVTVKDGAPKVLSIGGDAPKPKAKVLSIGVPAAAAPKKEEAKKEPAPTDTPEAGAKVAAVKAIEKSEKAAGDSGKTSPSPSSGRSSPTRAANKAATREADAVEKEIASADVDEETLTSIYGKEHVNIIFIGHVDAGKSTLGGSILYATGMVDERTMEKNKKEAKDMGRETWYLSWALDLTKEERSKGKTVEVGRAHFETEKRKYSILDAPGHKTYVPSMIGGASQADVGILVISARKGEYETGFEKGGQTREHAMLAKTQGVNKLVVVINKMDDPTVEWSEKRYQECTTKLSNFLKQTGYNLKKDVFFMPIAAQQTMGIKDRIPPGVCSFYDGPSLLEYLDNMTTLERKVNAPFMMPVNGKYRDMGTIVEGKIEAGVVKKGMGLILMPNRDKVEVAAAYGETEDEVDIAQCGDQARLRLRGIEEEDILPGFVLCSPKRLVHCVSAFEAQIVILDLKSILSAGFNCVMHVHSAIEEVTFAALLHKLQKGTGRKSKVPPTHAKRGDSIIARMEVIGGAGSVCVEKFEDYPQLGRFTLRDQGQTIAIGKITKLITEEVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHV2</accession>
    <name>A0A3D8SHV2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NAD(P)-binding Rossmann-fold containing protein-5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHV2"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF22">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW85919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="333" mass="37065" checksum="B373741013CEA586" modified="2019-01-16" version="1">MTRNVVISAVDGQTGFLIAELILTNNDFSSKIDSVFGLAMDINHSKCKLLKELGAEILHHVPGIEKDIVKILKHANADTICIIPPAHEEKFDITMELINATKKANMQNVCLLSAAGADMAERDKQPRLREFIDIEQAVLITKGDTSTETGHSPVIIRAGFYLENLLAYSPQAKNDRVIPLPIGDSHKFAPMALGDVALVTAHVLSGKGEHGFDDKHRGQLIVVTGPLLTAGNELAEAAKQALDEDMEFEDISPREAERVLKKQAETNISEIQYLLEYYSLVREGKLNYISTNAFHDITGQHVQEPVEWFKIYKSEFVKGEEKHQNKKRKMNGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SI58</accession>
    <name>A0A3D8SI58_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Epoxide hydrolase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_03783</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SI58"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="4">
        <location>
            <begin position="3"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW85458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="388" mass="43589" checksum="6B5AF2BCC18348F0" modified="2019-01-16" version="1">MKIEPFKIHVPQSEVDSLRVRLANTRWAPELDNEDWSGGVNGTYLRELMTYWQDGFDWRVQEARINSFPQFRTEIDGVPIHFIHVRGKGPNPVPILLNHGWLWTFWDFREIIMALADPAAHGGDPKDAFDVVVPSLPGFAFSGPLRRTDVGYVETADLWVKLMRELGYERFVTHGGDAGAFVSARLGHAHPESIIGVHLSFPILPGVAHDAGDPADFTPEERTLVEGQDRGPGAFVHVLINAFDPQTLAWAMHDSPVGLAAWILLRRRAWSDCHGDVETKFDKDTLLTHLSLYWFTESFVGSQLFCRASAFPQPMALVNDIKPEINVPTAVAVLPKDLMYKSRSIVAAHSDLRQWTLFPSGGHFGAAEEPKLMTEDIRSFVGPLREHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SM91</accession>
    <name>A0A3D8SM91_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Enoyl-CoA hydratase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_03131</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SM91"/>
    <dbReference type="OrthoDB" id="2018133at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000001">
        <property type="entry name" value="Probable enoyl-CoA hydratase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF54">
        <property type="entry name" value="ENOYL-COA HYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW87437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="34150" checksum="4DA54800BBA5685B" modified="2019-01-16" version="1">MDFSSATSLVQVSADGHVALVEINRPQKRNALSQDTIDCLVGAIAKVEKDENIKVVILTGSRRTGPFSGMSFPDLLGRHEVVVTACHELCTSVVVCDRSFAVVEQVRREAELRLLGGTVPELEMVEAQAERAVNFPGADLSELRHLSTAEAHRIQYLKDLADAVTSMRKPIIAAVAGFACDIIYAADDAQFGLPELSVGTIPGAGGTQRLTRLAMDMILNSLTITGEELRHYGLVAQTFPTDALLPATMAAAQKIASRSTPVVQLAKQAILNAEQTHLDAGLALERSLYYGSFSLDDRTEGMAAFVEKRQPVFKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMB2</accession>
    <name>A0A3D8SMB2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein PBDC1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_03157</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PBDC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SMB2"/>
    <dbReference type="OrthoDB" id="10248897at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3560.10:FF:000001">
        <property type="entry name" value="Protein PBDC1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3560.10">
        <property type="entry name" value="yst0336 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023139">
        <property type="entry name" value="PBDC1-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008476">
        <property type="entry name" value="PBDC1_metazoa/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021148">
        <property type="entry name" value="Polysacc_synth_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13410:SF9">
        <property type="entry name" value="PROTEIN PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04669">
        <property type="entry name" value="PBDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Polysaccharide biosynthesis" evidence="5">
        <location>
            <begin position="22"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00069779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW87463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="151" mass="17577" checksum="D13496052CD6DF9E" modified="2019-01-16" version="1">MSLAPAAPADFNPEEADNLEDIEKQFAVKAVQHMSTYWAILEKVPGSTLRLTKIDDEIYEHLKQDFPDFDPAATINEDEMKSKAGKERWRKFMMAYEKRVDDYNFGTIVRTNPKFEYGEKETIFVPRMQFYAIEIARNRAGLNDWISGKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SN37</accession>
    <name>A0A3D8SN37_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_03396</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SN37"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="74"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW87702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="514" mass="55568" checksum="60931252602FB5A1" modified="2019-01-16" version="1">MLAVTVSKDVRRPRLGGELSPNGGPFKFLTYTTTGTNSLEEAIISLRGSLKASEILTPGDENYGQSIRRWSDAVERKAGLVVYATNAEDVSRTLIWAKRQALETVVCSAGHSCSGSSSTQGGVVIDLSMMRKVSVSPEKQVIVAQGGCRWEEVDAEAAAYGLATVGGTVNHTGIGGLTLGGGYGWLSGKYGLTIDVVLSMQVVLADGEIVTASAAENPDLFWALRGAGQSFGVVTEFVFKAFPQKQKVWSGLLVFTSDKLEGILDFANKVPDASQNGANGVILGLSAPPPLGGDIGIMVAVFHDGSSETGEEYYKPLLELGPLLNTVSEIPYKKLNSILNQPNQYGGRKTMKGFTFITPLSADFLRGVISDLKTFLGKNPNAAETVILLEMYDQKKICSVSHTATAYGNRGMYQNGCVLPQWTKEELDMPIREWTREMARKWQVEMKRMKKDGHNIEMEGAGQYGNYDSFGSSAKDIFGPNYDRLVELKTKYDPSNVFSKSIALLPGQFGTTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SNG2</accession>
    <name>A0A3D8SNG2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitrogen permease regulator 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_03428</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SNG2"/>
    <dbReference type="OrthoDB" id="338854at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009348">
        <property type="entry name" value="NPR2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991:SF10">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991">
        <property type="entry name" value="NITROGEN PERMEASE REGULATOR 2/TUMOR SUPPRESSOR CANDIDATE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06218">
        <property type="entry name" value="NPR2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW87734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="533" mass="60330" checksum="2FC6F19BE5E07387" modified="2019-01-16" version="1">MAALPKIPIELMEDKEALKKILASILLLVSASSGIPAYGLQGSFQSLSLCIRRHGSLAVHLFHGGYPFNGQSEPLKDFQAGANMIEAIFFARFLPQEGTRVVYQSPPGSVVPEEGVDKPRLFDFEVLSEYVIPRQAFCNRIVTIKDPDYKYHIIGHPVCIQDPKYERNEFMFNFCIVIRVDIKPTPYKTAVRRLAGHFTEMEIQSQFLSQIDESNTQERRAIGPLLEIIKEDLNNYNECNVPVDDANTINMKLFTIHATPPHIKSWHVPIMKTKVNDIVDDTWDLSMQKVIKEIDGIKDVRRIAHDADVALNLTKIALRHLAYYETIIVLDMFLFGNIYQPTAEVKDFIDDKDDMQTECGNYCLINGPRIDNFYLCRLFTSLITGRTLKEWIKMHLDQGFEILKFVDVRRFIHYGLVKGLIYRVHKYAISHQHLLEKATSSPSHSAPATAPAATAAAANSGAGTLSGATAHTPAQGHWHATETPASPKDHLLYKYTDGCHPFDQITTEKNMGDPKIMDSLRKWPKGDLEVMYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SNL6</accession>
    <name>A0A3D8SNL6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-1,3-glucan synthase</fullName>
            <ecNumber evidence="2">2.4.1.183</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_03609</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[(1-&gt;3)-alpha-D-glucosyl](n) + UDP-alpha-D-glucose = [(1-&gt;3)-alpha-D-glucosyl](n+1) + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19749"/>
            <dbReference type="Rhea" id="RHEA-COMP:11150"/>
            <dbReference type="Rhea" id="RHEA-COMP:11151"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:28100"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.183"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.183" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="512920at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047657">
        <property type="term" value="F:alpha-1,3-glucan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070600">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-alpha-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11323">
        <property type="entry name" value="AmyAc_AGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000058">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000073">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000052">
        <property type="entry name" value="Alpha-1,3-glucan synthase Ags2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058659">
        <property type="entry name" value="Mok11-13/Ags1-like_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058656">
        <property type="entry name" value="Mok11-13/Ags1-like_GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058657">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058658">
        <property type="entry name" value="Mok11-13/Ags1-like_Ig_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058655">
        <property type="entry name" value="Mok11-14/Ags1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058654">
        <property type="entry name" value="Mok11-14/Ags1-like_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013534">
        <property type="entry name" value="Starch_synth_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182:SF2">
        <property type="entry name" value="CELL WALL ALPHA-1,3-GLUCAN SYNTHASE AGS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47182">
        <property type="entry name" value="CELL WALL ALPHA-1,3-GLUCAN SYNTHASE AGS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26127">
        <property type="entry name" value="12TM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26122">
        <property type="entry name" value="CBM_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26108">
        <property type="entry name" value="GH_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08323">
        <property type="entry name" value="Glyco_transf_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26114">
        <property type="entry name" value="Ig_2_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26111">
        <property type="entry name" value="Ig_Mok13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017617247" description="alpha-1,3-glucan synthase" evidence="9">
        <location>
            <begin position="18"/>
            <end position="2376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1956"/>
            <end position="1978"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1990"/>
            <end position="2008"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2015"/>
            <end position="2037"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2049"/>
            <end position="2067"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2119"/>
            <end position="2143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2166"/>
            <end position="2186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2198"/>
            <end position="2222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2231"/>
            <end position="2250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2275"/>
            <end position="2295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2302"/>
            <end position="2325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="2345"/>
            <end position="2368"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="10">
        <location>
            <begin position="63"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1692"/>
            <end position="1754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1699"/>
            <end position="1729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW87915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="2376" mass="265914" checksum="E7673FD9C21BD363" modified="2019-01-16" version="1">MQWAITLLALVLHAVSALKYMPEYVDYNLNTNQSATSVLDYWGEWEGHTFTPSPANWRFPVYSIMLDRFVNGDPENDNANGTLFEHDIASNQIRNGGDIQGLVDSLDYLQGMGVKAIYMAGPPLINQPWEFDGYSIVDHSLMDFHFGTIQKWRDAIDEIHKRGMYVIMDNTVGTMSDLLGFEGYLNVSAPFTVKEHKVEWIQSRRYLDFDFNNEYNETCTYPEFWGQDGYKEPQAVMNEMTGCYNSDFDQYGDIEAFGVFPNWERSLSRFASVQDRLREWWPPVREKLEIFACIYIAALDVDGFRYDKATQVTVGPLSEYNNAVRQCARRFGKDNFFLPGEITLGNSFGATYIGRGRQPDMLPDDAKTAISLDSNSSSEYFIRDAGSSALDGAAFHYSIYRYLERFLGMNGDLTASYDTPTNFVDAWNEIMVTNDMINAETGVFDPRHMFGTVNQDLFRWPAIQNGTRKQLLANFITTVHMPGIPLLLWGEEQAFYILDNTADNYIYGRAPMSSSLAWQTHGCYSLSPYSSQFYQMPIGPAATGCEDDWVSQDHRDPTHPIRNILKRMYQMRTIYPILNDGVYLEQLSNLTEQVFYVGSNGTSTETGMWSTVRGAYSGVQDFSDQTYGNQSVWLVYTNENQTKEFQFNCADSSTVRETTALISPFSSGTTVKNLFYPYDEHTLVASTLFLGLDGSSKASGCLSNMTLNAWEFRAYVPVANWVGPKPMLTSFAPGHDNRILSNVSGSETESVQVKLEYSTEMDCNAVTSSIVLNSTTVGGKVPSIDASSIVCGNVSTPSTSNLSGYMPGIWQWSATLNNVEHGIHLLTVNNVSSAAGDTTDSIDNLMFRIGASDNPMVFPRVANYSSELLYQYGNGSLFVSHKASGADKWRYSTNFGTTFSNWLDYTGGNVSITEQSWNGTDKQGWDGKHVRVEYWSRIAGSSSHVQEGDLNWHGPARRWPHMFLEGPFNQYGYDAGLSNEFKLNSSGAWNLHFMWEWPTTVQVNIWGMNPDKKPDETYVFGDADNDAVLDRELPNALKSTVINITASPPRPYLAWRVVVDDANLAFSLHPVGSEGVQLTLYCLLWVLPPLLGGLLVLLFVQSFYKVKFNESGAVKRRSFSLLGLGEAHRLQTVPGSLTWLANKSGLLHSPPEILNATEKRRKVLIATIEYDIPDWEIKIKIGGLGVMAHLMGQNLGHQDLIWVVPCVGDVEYPEDEMAEPITVTILGMEYQIGVQYHLVQNVTYVLLDAPVFRQQSKSNPYPPRMDDLESAIYYSAWNQSIAAVSRRFPIDIYHINDYHGSLAPLYILPETLPGCLSLHNAEFQGLWLMRTNKEAEEISSVFNLPAETITNYVQFGQGFNMLHAGVSYLRIHQQGFGAVGVSSKYGKRSHARYPIFWGLKNVGQLPNPDPTDLGDWNPEMIPKDKKDVQIDPDLEANKREWKKEAQEWAGLTIDDTAELFVFVGRWSLQKGVDLIADVFPSILETYKNVQLICIGPVIDLYGKFAALKLARMVELYPGRVYSRPEFIALPPFIFSGAEFALIPSRDEPFGLVAVEFGRKGALGVGARVGGLGQMPGWWYTVESASTSHLQTQFKQAIKDALGTKTKKRAIMRAQSALQRFPVVQWISQLDELQSMAIQMHGRALQSHHPWSRISSMIDLHSKTSSVTDVDQLATEAKITQLGLNQRFSLGARHEGASSIPGSQDQDASNAGSLSIESDSARTASNSLPHSNGHDNAEGPFESGHIEQEEEDHTQEKFPNLSNISHSLMPEDPARAGHQWASVPQEDLSMPATPMGNSLAPPSPHFLGSKNNRMSTISILSVDSIVGGKKDFNLQEVVPVFTDATGEFTEKFRDMLENLSARNSEFALCIGDYVEKSEKKWFDRYRKTKFQRQSAVSLVSYGMEPNSRMISPSHPSDAGDSMSHHEDPITDGEFQLGRDYKPPTGVKRLFLRRIGSWPVYSFFIALGQIIAANSYQITLLAGEVGETAGKLYAIAIVYMIASACWWLMFRRFDAAVCLSLPFLFYGIAFVIIGISPFVSSGQALMRNFGLGFYSVASASGSIFFAVNFGEESGDALKSWVFRATMIQGTQQIYIAALWFWGDKLSSAQANNKAWAFSNTWKMTAVCMPIACLCFIVMVLMALGLPDYYRQVPGKIPSFYRSIWRRKVIVWFFIAVFIQNFFLSAPYGRNWSFLWSSNHAPAWAVLLLVLFFFVGVWAVLLYFFSILSKDHSWILPIFAIGLGAPRWAQIWWGTSNIGLYLPWVHGYVFGALLSRSLWLWLGVLDAIQGVGFGMILLQTLTRMHVLFTLLAAQMVGSVATILARAVAPNKLGPGPISPDISEGVGAVLNAWFFVALIFQLVVCVGFLIFFRKEQLSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SNP6</accession>
    <name>A0A3D8SNP6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation factor G, mitochondrial</fullName>
            <shortName evidence="10">EF-Gmt</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Elongation factor G 1, mitochondrial</fullName>
            <shortName evidence="10">mEF-G 1</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Elongation factor G1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">MEF1</name>
        <name evidence="12" type="ORF">BP5796_03112</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Protein biosynthesis; polypeptide chain elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SNP6"/>
    <dbReference type="OrthoDB" id="198619at2759"/>
    <dbReference type="UniPathway" id="UPA00345"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070125">
        <property type="term" value="P:mitochondrial translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01886">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16262">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01434">
        <property type="entry name" value="EFG_mtEFG1_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04097">
        <property type="entry name" value="mtEFG1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04091">
        <property type="entry name" value="mtEFG1_II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000003">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000001">
        <property type="entry name" value="Elongation factor G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000022">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000015">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000558">
        <property type="entry name" value="Elongation factor G, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00054_B">
        <property type="entry name" value="EF_G_EF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009022">
        <property type="entry name" value="EFG_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047872">
        <property type="entry name" value="EFG_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035649">
        <property type="entry name" value="EFG_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004540">
        <property type="entry name" value="Transl_elong_EFG/EF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00484">
        <property type="entry name" value="EF-G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009381">
        <property type="entry name" value="PRK12740.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43636:SF2">
        <property type="entry name" value="ELONGATION FACTOR G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10 12" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="8 10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="99"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="108"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="183"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="237"/>
            <end position="240"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW87418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="804" mass="88926" checksum="D143B108F75F8FC0" modified="2019-01-16" version="1">MRMHKAVRVAASAEASIGCLRGCVPRSRFFCLNASKPVQPTSIGGSSTRARPSQRLFSQSTRIRAAAAEAVLKAAAANPNLAQEEIVKNLDPVEKERLNRIRNIGIAAHIDSGKTTATERVLFYTGRISAIHEVRGKDAVGAKMDSMDLEREKGITIQSAATFCDWVKRENGKDETYHINLIDTPGHIDFTIEVERALRVLDGAVMILCAVSGVQSQTITVDRQMRRYNVPRISFINKMDRMGANPFKAVDQINQKLRMPAAALQVPIGSEDSFQGVVDLIRMKAIYNDGPKGEIIRETDEIPEECKQIAEERRNMLIETLADVDDEIAEIFLDERVPTQEQLKAAIRRATIALKFSPVLMGSALADKSVQPMLDAVCDYLPNPAEVENLALDTRKAEAPVKLVSYNSLPFVGLAFKLEEGNYGQLTYIRVYQGTLKKGMNIFNARSDKKVKVPRIVRMHSNEMEEAPEIGAGEICAVFGVDCASGDTFTDGGLPYSMSSMFVPDAVISLSIKPKTTRDGSNFSKAMNRFQREDPTFRVHVDPETQETIISGMGELHLEIYVERMRREYGVAVETGKPQVSYRETITERVEFDHTLKKQTGGAGDFARVVGWLEPMEMTENGYATPKFENQVTGGAISEKFIYACEKGFMLSCEKGPLLGHQVLGTHMVINDGAIHLTDSSEMAFKNATQQAFRKAFKEGKGQVLEPLMKTTITAPNEFQGNIVGLLNKRNAIISDTEIGPEDFTLTADCSLNAMFGFSSQLRAATQGKGEFGMEFSHYAPAPGQLQKELISAYEKNQAERNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SPH8</accession>
    <name>A0A3D8SPH8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">tRNA(His) guanylyltransferase</fullName>
            <ecNumber evidence="3 14">2.7.7.79</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">tRNA-histidine guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BP5796_03392</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 14">Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a 5'-end ribonucleotide-tRNA(His) + GTP + ATP + H2O = a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54564"/>
            <dbReference type="Rhea" id="RHEA-COMP:14193"/>
            <dbReference type="Rhea" id="RHEA-COMP:14917"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:141847"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.7.79"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="16">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the tRNA(His) guanylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.79" evidence="3 14"/>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SPH8"/>
    <dbReference type="OrthoDB" id="62560at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008193">
        <property type="term" value="F:tRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3000:FF:000001">
        <property type="entry name" value="tRNA(His) guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025845">
        <property type="entry name" value="Thg1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024956">
        <property type="entry name" value="tRNAHis_GuaTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007537">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038469">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729:SF6">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04446">
        <property type="entry name" value="Thg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14413">
        <property type="entry name" value="Thg1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028980">
        <property type="entry name" value="tRNAHis_guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 14 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 14 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 14" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNAHis guanylyltransferase catalytic" evidence="17">
        <location>
            <begin position="6"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Thg1 C-terminal" evidence="18">
        <location>
            <begin position="139"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="29"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="75"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR028980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF14413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RDW87698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="289" mass="33547" checksum="17C1D86B00AE8172" modified="2019-01-16" version="1">MANSKYEYVKAFEQPDLLLPNTWIVVRIDGRGFHKFSDKYTFEKPNDRRALDLMNAAAMKVMSELPDIFIAYGISDEYSFVFHKSCTLFERRSSKLVTTIVSTFTAYYVHLWSNFFPDLPLTAPLPSFDGRAVQYPSVQNLRDYMSWRQVDCHINNLYNTTFWALIQNGGMDAKTAEKELAGSLAADKNEILFSRFKINYNNEPEMYKKGSIVFRDYELVEPGTVELEDDESAKTVEEAALSKTQAEKDRKRKAKARITVQHVDMIKDEFWERRPWLLSNKPGKVPKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXJ1</accession>
    <name>A0A3D8SXJ1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SXJ1"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="63"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="589" mass="65715" checksum="7B5ADB9BE4E58B14" modified="2019-01-16" version="1">MEIHVDTVSQNTKFTYGPLHGNAGEIRLIELLPGDEWSPIECILRIVALPINDTGKTGAEPVYSAVSYTWGSIDRRRSVKLDGKSMSVRENLWMALFYLRSRTDSLTLWIDALCINQSDVIERNDQVGRMGEIYGRAQQVILWLGKPTDESYHALNFFRSLTTSEQKEAEQIGSGDQKSKILQSSFDVCQRPYWRRLWVIQELVRATNIIIRCGTELISWDDLCSGLDFIKLHTIEEVLPQNALQRVLDLASLRKLYHQSGCELIQLLACSATAECLDPRDKIYGLLGLANDCKDEGFVADYNKSIWELYYDVMIFYSHQCMEQEASQGGVDWRIPGLVQFSGMLQQLLFQDIILGNSKPYTGSPKSELSEVFHFTGFFAGSVVAIGPAVSDLNDSENLRHGLLAAWYNIVRPKAVVERGQAYEMIRLALDLSIETAAGFSKRINPIRKSSSQAVIGPRARESITRTNSHDTVFPPPRNRCFPTIDSVKSSQLKGPRLAFVQYKSASWIGVVPFMVQPGDLVASFLGCETAAILRPSSGGHCGIFGTGMLVPCTADALSSLENDIDVLHTGQEEVAFSVDIKTLHKLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SY87</accession>
    <name>A0A3D8SY87_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_02448</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SY87"/>
    <dbReference type="OrthoDB" id="120072at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041524">
        <property type="entry name" value="GH131_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612">
        <property type="entry name" value="GH131_N DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34612:SF6">
        <property type="entry name" value="GLYCOSIDE HYDROLASE 131 CATALYTIC N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18271">
        <property type="entry name" value="GH131_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017558437" description="CBM1 domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="4">
        <location>
            <begin position="554"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="342"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="484"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW91283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="590" mass="59880" checksum="7DB352ABD12A7A18" modified="2019-01-16" version="1">MYFRSMALAALAGTASSTILWDGRFNNYTSSAEIADWSWSNEVGEYQYYIHGDSNITSYVNLDSTYKNPADSGSTQGVKITLDSTAYWEGQTMRRTELIPQTSAAIGSGKVWYHFSMMRSDVNPPSTYREHQIAFFESHFTEMKSGVSTTGASSDSNLRWEVSSTSQWNTTWDAGVWHNVAYEIDFDANTVAFYHSTGADDLTLAVAAVSCTASSNGADWHLGVLEQPVTGQTDGTEDIYFSGVYIESGSLTTSVAGPGGVVASGSAVASVASSTTAQAASSSAAAAVASTSSSAVVVSSSSISVAPVSSSTSLISIEADSVTIPTTSGGVQVPTTSSTVVTSSSVASSSSTSKKPCSSVTPTSAAAATSTKKPCSSVTPTSSATSTKKPCSSVTPSASAASVAQAVSSDVAAQAVTSTATTTGAVAVSTVWVTDLFTVTACPSTVTNCPVGSLTSSVRMSTTHVAVTSTSAAAVAAVQASSSSSKKPCSSVTPTSAASATTTKKPCSSVYPSTMSTVTTKKSCSSVLPSASAVAAVVDSSVKTSYNSTSSGSGTIAKYYKCGGTGWTGSGSCVSGTTCTVMNAFYSQCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYS2</accession>
    <name>A0A3D8SYS2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GP-PDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_02083</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW90918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYS2"/>
    <dbReference type="OrthoDB" id="1058301at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46211:SF14">
        <property type="entry name" value="GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46211">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GP-PDE" evidence="2">
        <location>
            <begin position="11"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW90918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="267" mass="29602" checksum="573DAEC05DCD68AF" modified="2019-01-16" version="1">MNPLRTTPQTVRVAGHRGHSAGAPENTLAAFRLARELGGIGVTCETDLGLTKDGELILIHDETVDRTTDGYGLVRNMTYSEIAKLDAGRWFDKKFEGERIPLLKDALVLARQLGIIYQLELKIYDQDDVLFPKLRALIVELGCADLLQFSSFDFVQLRAAKKAFPEIPTVGISHSRLIEPAVVAREANVDAINLEIQHFPSGEAHQLHQGGIAVFLLLPPPEILRDLKTYGVDVEAQVINWVREGLLDQILSDDVAQVARIMKHVRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYT8</accession>
    <name>A0A3D8SYT8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ATP-dependent RNA helicase DOB1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_02640</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. SKI2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYT8"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18024">
        <property type="entry name" value="DEXHc_Mtr4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13154">
        <property type="entry name" value="KOW_Mtr4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3380.30:FF:000003">
        <property type="entry name" value="ATP dependent RNA helicase (Dob1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000083">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000141">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.300:FF:000001">
        <property type="entry name" value="Mtr4 exosome RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048392">
        <property type="entry name" value="MTR4-like_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21408">
        <property type="entry name" value="MTR4-like_stalk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="164"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="400"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="625"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW91475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1078" mass="122420" checksum="6865AAD22FBA813F" modified="2019-01-16" version="1">MDDLFDVFDDAPKGVTSNAATKKPKRDKKDKIKKRKANGDVKAVSDVQDGDEEMADELPAVEDDAEEEDDEIQEQQENKRRRRDIEAEPVVTDTFQTEQSRQLAASAGLQGSKDDGALVLQHNIQHQVSLPPNYNYIPISQHKSPETPARKWPFELDPFQKVSIASIERGESVLVSAHTSAGKTVVAEYAIAQSLRNNQRVIYTSPIKALSNQKYREFAAEFGDVGLMTGDVTINPTATCLVMTTEILRSMLYRGSEIMREVQWVIFDEVHYMRDKTRGVVWEETIILLPDKVRYVFLSATIPNSMQFAEWITKTHNQPCHIVYTDFRPTPLQHYFFPAGADGIHLIVDEKGNFREDNFQKAMATIEEKKGADPADINAKRKGKGKDKKTNKGGNKEGSDIYKIVRMIMLKHYNPVIVFSFSKRECEAYALQMSSMAFNDDSEKAMVTKVFESAIESLSEEDKTLPQIQHILPLLRRGIGVHHSGLLPILKETIEILFQENLIKVLFATETFSIGLNMPAKTVVFTSVEKFDGVAMRYLTPSEFIQMSGRAGRRGLDDRGIVIMMIDNKMEPATAKEIVRGEQDKLNSAFYLGYNMILNLMRVEGISPEFMLEHCFYQFQNTSSVSGLELELQELQNERDTMEIEDEAIIKEYYDLRQQLTSYAKDMRDVINHPNYCLQFMQPGRVVHIKHNDHDFGWGAVVKFTQRRAPKGQVADFPPQQSYILDVLLPISDGSSVGTKTDTDLPSGIRPPGPGEKGKMEVVPLLLSCIEAIGHVRIFLPKELNSIENRTTVRKSLDEVKRRFPDGIATLDPIENMGITDDSFKKLLRKIELLESRLLTNPLHNSPRLADLYNQYASKIEIGKKIKEKKKAISAALSIMQLDELKSRKRVLRRLDFINDGEVVQLKARVACEISSTGDGHELLLSELLFNRFFNELSPELCAAVLSCFIFEEKSQCPPLKEELAKPFREIQAQARIIAKVSQESKIKINEEEYVQGFKYELMEVVLSWATGKSFAEICKMTDVYEGSLIRLFRRLEELLRQMAQAAKVMGSEELAARFEESLTKIRRDIVSAQSLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYZ5</accession>
    <name>A0A3D8SYZ5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_02681</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYZ5"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="49"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW91516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="286" mass="31196" checksum="CB4B50F8BF541381" modified="2019-01-16" version="1">MSTSVQDKDQWSDNAESYAKGSQHLSNAPVEILFTQMNHTLSFSTATAILDVGSGPGVTIARLVESYGSQLPSNTRLIASDFSVGMIEQVQKLQKHKQDGSPIWTRVEAKVLDAQALDGIEDASISHITGTMVYNLVANGRQALEAAYRVLQPAGVIGMTLGAGAEWMELMGLAAKKIRGETAPIYQFPEAYSTLKGVRAEFEAVGFNAEYLETVEFFIDVTNPKPFIDSFLRGKNPGAMFFVGDYSGVELDAFVDEILKLIEERHPGFPRKLKGLMIVAVGKKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZI8</accession>
    <name>A0A3D8SZI8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Oxidase ustYa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_02908</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZI8"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW91743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="33755" checksum="219AEF6CF13BA849" modified="2019-01-16" version="1">MNNQHDPLSSRPLVSSQEYSEVKNEDFEETACEDSITQRSPSTELPAYKLRRSAWYPDMRVMISREVLAVHLVWLLILAATIYVLGRFTPEVKCGVSRLPSDVVFGDIPYQIVNWDEDSGFVNSDPLDGKRWNQSREWADSTDWTPWDDIHPGSWVQVAPSSKLGISGGIPLRDYSKDGSWDTNDEGYALTMHHQIHCLGLMKHVFISAERNEPIPSTSFRHMDHCVEYIRQSIMCYGDLTLEPLQLGSSQKAIESDTWGSKHFCRDWTALKEAVWERSTVGFDRHGFVFDKVIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0M2</accession>
    <name>A0A3D8T0M2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Acyl-CoA desaturase</fullName>
            <ecNumber evidence="16">1.14.19.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BP5796_01516</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>octadecanoyl-CoA + 2 Fe(II)-[cytochrome b5] + O2 + 2 H(+) = (9Z)-octadecenoyl-CoA + 2 Fe(III)-[cytochrome b5] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:19721"/>
            <dbReference type="Rhea" id="RHEA-COMP:10438"/>
            <dbReference type="Rhea" id="RHEA-COMP:10439"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57387"/>
            <dbReference type="ChEBI" id="CHEBI:57394"/>
            <dbReference type="EC" id="1.14.19.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="16">Expected to bind 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the fatty acid desaturase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.19.1" evidence="16"/>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0M2"/>
    <dbReference type="OrthoDB" id="10260134at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004768">
        <property type="term" value="F:stearoyl-CoA 9-desaturase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006636">
        <property type="term" value="P:unsaturated fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03505">
        <property type="entry name" value="Delta9-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000004">
        <property type="entry name" value="Acyl-CoA desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009160">
        <property type="entry name" value="Acyl-CoA_deSatase_haem/ster-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015876">
        <property type="entry name" value="Acyl-CoA_DS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001522">
        <property type="entry name" value="FADS-1_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351">
        <property type="entry name" value="ACYL-COA DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11351:SF31">
        <property type="entry name" value="DESATURASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000345">
        <property type="entry name" value="OLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00075">
        <property type="entry name" value="FACDDSATRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00476">
        <property type="entry name" value="FATTY_ACID_DESATUR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 16" id="KW-0249">Electron transport</keyword>
    <keyword evidence="15 16" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8 16" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 16" id="KW-0349">Heme</keyword>
    <keyword evidence="12 16" id="KW-0408">Iron</keyword>
    <keyword evidence="4 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="14 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 16" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="19">
        <location>
            <begin position="344"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR000345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RDW92122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="471" mass="53608" checksum="BAAB57AF127C5464" modified="2019-01-16" version="1">MATPPQYASQQPSSMAQQSEPNRNKKYDPKKPHITEQPITRANWYKHVNWLNVTLIIGVPIYGLVQAYWTPLQWKTAAFAIAYYFMTGLGITAGYHRLWAHTSYSATLPLKIFLAAVGGGAVEGSIRWWSRDHRAHHRYTDTDKDPYSVRKGLLYSHFGWMIMKQNPKRIGRTDISDLNDDPVVVWQHRNYIKCVIFMGMIFPCLVTGIGWGDWFGGFIYAGILRIFFVQQATFCVNSLAHWLGDQPFDDRNSPRDHVITALVTLGEGYHNFHHEFPSDYRNAIEWHQYDPTKWSIWIWKQLGLAYDLKQFKQNEIEKGRLQQLQKKLDQKRQTLDWGIPLEQLPIIDWDDYQAEAKKGRGLIAVAGVVHDVTDFIKEHPGGKALITSGIGKDATAIFNGGVYNHSNAAHNLLSTMRVGVLRGGCEVEIWKRAQRENKDISFVSDTAGQKIIRAGSQVTRIAEPVASADAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0R9</accession>
    <name>A0A3D8T0R9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_01528</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0R9"/>
    <dbReference type="OrthoDB" id="4991875at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40640:SF1">
        <property type="entry name" value="ANCHORED GLYCOPROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017662123" description="GPI anchored protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW92134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="21763" checksum="0F3687ABBE0A9293" modified="2019-01-16" version="1">MYKHSVAALALLASVVSAQSTTSLYLIGFDQQPIDASIVGSDATATTYSLSCPSTTSAPVAAASSDFNSDICGVPTSMFVTQGPSTLHLAYSAVFESVTDAVTIGCDLSGTTSALCSGTEMLVNGTSTSTTVETTSYTGNLADMSTGLGAVAVTVLGSGSATAGSSASTGSSKATTKATGTASGASATGTSAQGTSTSTGGVPMVTGNAKWVVGGAAAAAGLAIAGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0V6</accession>
    <name>A0A3D8T0V6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxidase ustYa</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_01601</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0V6"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF6">
        <property type="entry name" value="OXIDASE USTYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW92207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="256" mass="28804" checksum="D8A885DCB962AE3F" modified="2019-01-16" version="1">MSLGKEPVKMDEDCEKLLEASSETSSLEATDNIPTLRDRTKNVANIRVYKIAGCFLVFLLCLSNLFWYLQLPTANRHSNEVTDPAYFGKPEKVLTSFDHDWKGLGDVEVDGVKYADDRWEHTYPKYGGSIALSFEYAAKYGLPLGDVTGDNSSEMHYLVAGYHQMHCLQVVRETIYQLNGTSTNTDPILWDHVLHCIEAVRQAVSCFMDPTLINLSVIWPGIPNGQRHVCRNKDALFAWTEEHAHPLPPIPGGPIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1L4</accession>
    <name>A0A3D8T1L4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GPI-anchor transamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_01292</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1L4"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003923">
        <property type="term" value="F:GPI-anchor transamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028361">
        <property type="entry name" value="GPI_transamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067:SF1">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500138">
        <property type="entry name" value="GPI8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019663">
        <property type="entry name" value="Legumain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5027981351" evidence="7">
        <location>
            <begin position="25"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="361"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR019663-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW91898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="430" mass="48210" checksum="8AED4DA358B665C1" modified="2019-01-16" version="1">MRLSKLLQLPLVLTSLLLPLPVAAEHTSNWAVLVSTSRFWFNYRHLANVLSLYRTVKRLGIPDSQIILMLPDDMACNPRNAFPGTVYSNADRAVDLYGDNIEVDYRGYEVTVENFIRLLTDRVGEEMPRSKRLLTDDGSNILVYMTGHGGNEFLKFQDAEEISAFDLADAFEQMWEKKRYARFTSLMPELELTQPPIHRYHELLFMIDTCQANTMYSKFYSPNIIATGSSEIDESSYSHHADNDVGVAVIDRYTYYNLEFLETKVREPSSKTTVGDLFDSYDSAKIHSNAGIRYDLFPGGEKAARERLLMDFFGNVQNVEVDTSNSSSGNSMDAEWEEDILALGKKISELRKRQEALDLQAQAQVSNSSSVPPPGSPKSEVKLPTSKIRAAKVEVDNSWFGKKAVGAWALAGCSLVWLAGSYLESSPSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T202</accession>
    <name>A0A3D8T202_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_01923</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tannase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T202"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF8">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW92529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="498" mass="54589" checksum="A6BBB9C8A936AF5C" modified="2019-01-16" version="1">MTISTPPHFSGQILRVSQVSVSNYTTLTPYTGDIGAAWYNDLEFCNITVTYTHPDQNDSVNVEIWLPPPESWNGDFQGQGGGGWFTGLPNLSHPQSISQGFAVASTDGGHYQGRTPLDWGMRSPGHVAMHLLKDFASVALHDMTLLAKEVVESYYGTKAKHSYWHGCSTGGRQGLMLAQKYPTDYDGILALAPAINWDRLLVATFWPQLVMQQYGVFPPGCEFEAIRQKAVEACDGLDGVVDGVVAAPGLCQFDPMTLIGQPFLCDKVQLSFTEDAAKMAKLMWRGPQITAGRFMWYGLTPDASFAALGGTSCSKWNVTSCLPSPFSMATEWLQVFLAKDTNLDTSTITPTEYETFFYDSIDQYASIIGTSNPDLSAFRAAGGKMITWHGLSDSIIFPNGSSNYYERVLEQDPHARDFYRYFEAPGVGHCNPLAGIGAYPVNVMADIVKWVEQDEAPEVLNATGGEGKTRNICLYPLVSKYIGGDQTLAESYVCAETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T6R6</accession>
    <name>A0A3D8T6R6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_00006</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T6R6"/>
    <dbReference type="OrthoDB" id="4451586at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052761">
        <property type="entry name" value="Fungal_Detox/Toxin_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47425:SF2">
        <property type="entry name" value="FARB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="54"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="100"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="716"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="716"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW94243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="868" mass="96964" checksum="FD100A5877719A6A" modified="2019-01-16" version="1">MTSEIPTTPSDRASSSQSPSADAGTAASKKRANSTAALDHAGNPKPVKRRAAKACAACRARKVRCDVMQRYHITADGEVTCSNCTMDGIKCIIEESKRRKKHFNNPSTQTTTTTTTAAKPPANPNPQSWGSGLVNPTEVSNPDARRWSSGSAVASNDGGDEFTSQHVPHSIYQNVTKQIDKGELLRQAYQRRLQNPDPSYSLLTAVSPHGDMTSVRSRLLSPPAPPALVPKHKFPDYLKPLPQRMTPVDIDYLFAKGALSLPDEPTRNALLQSYLEYVHPYMPLIELHEFLQIVNDGTGQLGRISLLLFQAVMFAGTAFVDMAYLRNAGFTNRKAARKAFFQKARVLYDFDYEVDRVSLVQSLLLMTYWYETPDDQKDTWHWMGVAISLAHTIGLHRNPEKSNMEPNKKKLWKRIWWSCFMRDRLVALGMRRPTRVKDEDYDVPMLTEEDFELVSLPDHVTIISRDCTIVRDVEAQRELAQMCIAKAKLCLCISHVLGAQYSVLVKHQGMQGQEGSTRSSVMLFPKKLDQTDEVKQCDVELNDWINELPPACLYSNDIAPGASGASLFVQRSLLHMVYFTTLSALHRPQVLPAAETIEPDKCRELQDLSRKKVREASREITRISQDLHTLGLEKYLPTTGVTVLLPAIIIHLLDIKSCNDEARQAAMEGFCQCMLVLEKLRDNYSSADFATQFLEAAIRKADIDVVMGRGQEKFRQAEAVRRQELQPDRRTPPPTSEEITSVQYHKPTVQIDPLHNSISARTPPEHGEENISATPAAVHNGLPLTQEVNILDTNIDLNDFLNFDASNEMWNVPLEEGAHGESGGFMGDMNWIDQAPGWSRLNSPIPELGLQNGGIWATEAKAEVDLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T775</accession>
    <name>A0A3D8T775_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_00152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T775"/>
    <dbReference type="OrthoDB" id="10377519at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW94389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="311" mass="33182" checksum="669D33BBEBCE7A4A" modified="2019-01-16" version="1">MAPASSVPKAHYTPIHTTILHLSLILAIITFISLFLAPCLRVQYLLQITTLILFFNVLFGQIPVLLTYPLHPRTFLPIGYERILKLGLALTWGAIFISLILISIILAVLLPSDATREGKSTGWLGVTMMSILAITLAILAITAQAPQYEDEEDSHVVQQPRAGKKPKDLGWARRGLVFGIYTLYILVILALLVAGGNAAMKAGSCQPLPTWQGHGNVASEVEVEVLVRDNATETVMQTSTVVALPTVTTTELSIVTSMSMGEVTVTVSASRESSAGDGRFSKGAGAPSSRGGIATVVVWTSTTTTVEVVAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7A5</accession>
    <name>A0A3D8T7A5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_00206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7A5"/>
    <dbReference type="OrthoDB" id="5420905at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="278"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="315"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="53"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="315"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW94443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="779" mass="88027" checksum="9721194B51C0FD46" modified="2019-01-16" version="1">MTSNLDYSSDGLLDLTFDPQNPRYSYSNMSARSSWPLPLDMASADADPRRSLSPGQSAQQHFHTTHHNSPTLLTDWPMQQQPQQMPHYLQDNSLMSAQYANFGQAFQASPLDYQMPTTQSGLESGLQMEAPFGGIGGLVQTVEAQAMQWANWQEFEQAMNFTGNDGLPSLGRQSLGSNSPTGTYLEVLSLPSSSSDNGWATVDAYQNFESYQQAQNAAIFNPGQTLHLRSHSDSSQSDGTGHTMESFGSYEDMTYPYSPYSPGSDNFIDTLAHRNCFHGDAHHSPQHSHHSPQHSHDIHEIVSPAAAVAPVPIKMSSTRTTPSSTSSPPARRNSAPKKSPITAKATKAVIRRTSNGKKDSEKRVGRRRGPLLPEQRKQASEIRKLRACLRCKFLKKTCDKGEPCAGCQPSHARLWQVPCTRIDIKDIGYFMKDWRADYERHVDLGMTLYNIKGFSEKEELIWITHGYGFAIPINAREVYVSDDSCFHIDWVESDHDEPSEFEVRTERMSAGAEGISKERLSEYLDQHLDGPFEEFIDSYFEGTPFITEILKTAHRYYLKEKLPVIRKALKLVLAYNLTMHVTMVENRGDEHPMDGYIDDEESNWAGRTVAPVMINFQIKCAMAEMWRELQKEILEELSSLYSSVYSGDRLKNWPTIFMLASILLAVWEEMQFDCHYRIPDAAVVNKFCTDMETTPVGVIVGLFHAISQKLPPFTEWETQRHGHLLNNNVAVCEAMTEMRGHVTKHESYLKTRPDAQFDRRDFDCLSNKFLSKLVIRAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7H3</accession>
    <name>A0A3D8T7H3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Stress response protein ish1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_00269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7H3"/>
    <dbReference type="OrthoDB" id="2527403at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018803">
        <property type="entry name" value="Ish1/Msc1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10281">
        <property type="entry name" value="Ish1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017550239" description="Stress response protein ish1" evidence="1">
        <location>
            <begin position="20"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW94506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="576" mass="62729" checksum="7D81675FB4C8AD73" modified="2019-01-16" version="1">MKLFAQLLVLGLAAEMTIASTWFSKAVYNKWHETELERWLSDNNVPYPTPADRKDLEALVKNNWQSKVASPYSDWEPSQLSSFLKHKGVESKEAAEASKDGLIAQVKNYWYETEDKAEDAWSSVKDWVFDSWTDSQLKAFADRHGIPVPQPRKRDTLLQKIRSNYESAAKKAGETAAYPGNWLYETWTESDLKEWLDSHGIPAPQPTSRDKLIASVRRNARLASLKMADAQASASASAAATAQTLSDQLLDAWSDSQIKEWLDKNNIPVPQGSKKNELIAIARKHRAAFMGDSAGASAKSAATKASASGASAFGAATSAAGNQYAKATEDAQLKAEDAWNSAIGTWSQSRLKAYLDARGIPVPQSGKKDELLAAVRLNKHKAATGWSAWTYDTWTYDNLKNYLASSGNEAAAKAANKAGATREDLVSAAQDAYASASKTGGSAFASVTSYLSQQTDAAKDTAFDTWSESDLKSYLDSYGVKVPQGSTKNEMVAFARRQRTWFQYGTTTPSGTLWAKIQNAGNWAMNQLSIGAAAGRKQASYQGEKAADRVKEGATYATNRAGEAAQKAGDRIKEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T896</accession>
    <name>A0A3D8T896_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL4m</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_00552</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T896"/>
    <dbReference type="OrthoDB" id="275876at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000016">
        <property type="entry name" value="60S ribosomal protein L4, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013005">
        <property type="entry name" value="Ribosomal_uL4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03953">
        <property type="entry name" value="rplD_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746">
        <property type="entry name" value="50S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10746:SF6">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="39"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW94789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="213" mass="24468" checksum="3B3331785A19E47C" modified="2019-01-16" version="1">MEPLRFESYPSNHLYLPLRRDILHRAVVYEGDATRQGTASTKTRWEIHGSHRKIRPQKGTGRARLGTRQSPMLKGGAKSFGPRPRDFATGLPKKMYDLAWRTALSYRYRKGELIICEDGMDIEHPKTRYVQDIFEHNHWGSEDGRTLLITGDYRHNLFNALRPAGQHGRVQTTEEVDVKDLLELGRIVIEKSALDEILHGHQSDLTSKVRAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8E1</accession>
    <name>A0A3D8T8E1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_00464</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8E1"/>
    <dbReference type="OrthoDB" id="10290766at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="149"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW94701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="245" mass="28446" checksum="618849F75F06F214" modified="2019-01-16" version="1">MDRLPTFYDGVTFLLVRVRKLIIRSIVQFRCISKLFRSFRQYHTNSPIRLLIGRQKKPQPTAIAHTRSGHLAMSDWQAEYLHFQHLLRIGPRIDFTPDRARSIPRTSSRKPQHIVTPRPGRSSNGGNYAWLGFLVAVLAIMYIETRATLNRAQDQLEIEIGRVKDLEEELHRRNLDLEKGENLRRSRLKNLQVALKRKEEEFDRSWDSAKELLHRKKGLGTEGCADNGMSADVELEDRTSSDTFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8G6</accession>
    <name>A0A3D8T8G6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_00626</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8G6"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW94863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="173" mass="18759" checksum="5F34DDDFE4C07F29" modified="2019-01-16" version="1">MALTKAALLSQPLIFCRAGVHPVFSSDHRNQSHNNKARPLPQLQTEHHNKRHCHPPLPDLPCPRYGPNPQYGLPRAPGPALPNSIAVRLARKRLIKGQMVSIKFSDRPATTTSVPSHPRPSTLHTQNFAGRSETSPTGPLSRSFTSAMTNLGFASASASACARHVRAEQEVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T918</accession>
    <name>A0A3D8T918_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3500 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_00799</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T918"/>
    <dbReference type="OrthoDB" id="4539697at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021889">
        <property type="entry name" value="DUF3500"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37489">
        <property type="entry name" value="DUF3500 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37489:SF1">
        <property type="entry name" value="DUF3500 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12006">
        <property type="entry name" value="DUF3500"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW95036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="430" mass="48746" checksum="ADD0F30B5A16B63E" modified="2019-01-16" version="1">MEPTLTSPSEFKKASAGFRTHLPDLTSPRFTTAKTQDATSYAKFFNDNKAPPWLHALTQAWGKLFNEPYKGVTSDGTVIPGLYKIQDEGVPIEEIKAAVEKVLSKLNQTQKDKIQYPINAKEWRAWSNPEMLLRNFGIRLEDMPEDVTLAVLSVLKTTFSPEGYEKAVAAMEINHFLGEICEIPKIMNRYSYNFLLFGTPSATSSWGFSVYGHHLCLNVFLKGPQIIISPTFTGAEPNIIDEGPRMGTSILYPEGDLGLKLMQSLPKESQKKAVIFEKMHDPGMKQTGDLTVDRWNKDDQRHLCGAFRDNRIVPYEGVLVSDMTAEQKKLVSDIAEQFLLYHPAQARQKRIATIESHFNETYFSWIGGYGDEDAFYYRVQSPVIIFEFDHHSGVFLTNTEPAKFHTHTIVRMPNAGDYGNVLREEDEKVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T958</accession>
    <name>A0A3D8T958_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RNase III protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_00839</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T958"/>
    <dbReference type="OrthoDB" id="2281895at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00593">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1520.10:FF:000018">
        <property type="entry name" value="RNase III domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040030">
        <property type="entry name" value="Ribosomal_mL57"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L15, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28160:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML57"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14622">
        <property type="entry name" value="Ribonucleas_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase III" evidence="2">
        <location>
            <begin position="105"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW95076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="259" mass="28400" checksum="4F659C8411B13231" modified="2019-01-16" version="1">MASKSASRSLQSISRQVQQRCTCASSRTAPAAIRQFSASSLRSGEQQTHGQEEQPRWARTPKQMIAPFQTRVKDPAKAFVVNEDPKKVDAMYVKLLGRGGDKVLDEEIKWLAITHKSFDQGRRGFNDRLAFLGRRILNMQTSLALLHSPLSTSTQSEPSANDPREPFRHTALEGLRNLADVNVSKVLTKERLGNLAVQMGLSQVVRWKPKSPSNLKASGVDVVMATTLYAIIGAIALQKGGDAAARVARERVLKALGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9S2</accession>
    <name>A0A3D8T9S2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_01030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9S2"/>
    <dbReference type="OrthoDB" id="2399539at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF23">
        <property type="entry name" value="THIAMINE REPRESSIBLE GENES REGULATORY PROTEIN THI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="23"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="169"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="256"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="256"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW95267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="570" mass="63011" checksum="D48B9A41C15824A0" modified="2019-01-16" version="1">MSSLVAGRPTPTKKAPRSTALRACERCRQRKRKCDEYFPCGTCTRLGIQCQVSEPDKKQEKSQSYLEAQIKRLERLLAARNAMLEPQHRCQLGPEASTCSSVPMQEGPSKLRLQIPSTPVYSQNEPDWYPALSSDYSNSPTLGSPHQAYPPLGYPVALDIPQWSSQISHSEQRDLVQSPLPRRRALSSPFPLSEGEEYHNQPDTSFDFNIDTDMLSPDIPTIQVTSWDVQSSGSAEPRGMGVNDYSLMTPGLSVGSWSGPPSPTSTAASSQLNYDDPLFLNPGSRSHSRRSSFAFSERSFDGLDFIDPRSTDAAFKPQPNASFLPSTQPAYFHAPVPAPALLSTLELNESEMQYAKAYFDLVQPLFPIISHENFRPLLKQSAQNHNNNYQRATVFLVLSIGSHLVPDAQPDSLKYYTLAQQCFDTKALPGAPSVEAIRTYTLLALRRIVCTDAMEDGAPSLYMLNAYIGAACVDSSLHQLCSDVEGDIFYTAYVLDRTISVMTGKPYCLHDSDISETVLEKVLEQAKSVKEELQNRTSLGSLGSLGERAGGLLEWYGMADIDLDDEFLCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8TCA6</accession>
    <name>A0A3D8TCA6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_01041</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8TCA6"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015233">
        <property type="term" value="F:pantothenate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098717">
        <property type="term" value="P:pantothenate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF4">
        <property type="entry name" value="PANTOTHENATE TRANSPORTER FEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW95278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="473" mass="51390" checksum="DE9C35488E4C8BBA" modified="2019-01-16" version="1">MSFAHKLRVLVWGEAAATAAERKLVQKIDFFVLSDVSPPTPSPEVRNLTKSDIVGQVPHALALNYVAPHIYLPSMTVIWAGLTMCSAAVQNYPAMMALRFLLGAIEASTFAGTHYIIGSWYTPQEVGKRAGLFAASGQAGTMFAGLMMTAMYKSMDGLAGMPGWRWVFIIDGIITLPIAVFGFFYFPDLPATTQAPYLSTEERLLAVSRLPPKKTHQKVDLALLKRVLSSWTAWVFVILWFFGGLVESLSTYTCMLLWMKTAGYSVVQNNTYPLVIQAVSIVSILGVSIALDASQKRLPWGLLTCGIQIITGIILLNWSHIGDGARFAAYWIAGTAYAMQPITFTWANIVLARDGDNLARSIVLYSMNGASATASTFWGVELYPATDAATGFFKGNVALVAVSVFTAFWFCLCWVEDRRTLREFSVGAGRVASATEETGASRMGVNSGKDTVIVGEEVNEDGDVVANSKGDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q2W5</accession>
    <name>A0A3D8Q2W5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_13252</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000031">
        <property type="protein sequence ID" value="RDW56341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q2W5"/>
    <dbReference type="OrthoDB" id="3477286at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="111"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW56341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="771" mass="88344" checksum="A885260F1F15DAF9" modified="2019-01-16" version="1">MPQANKGRNRKRARSPEHTANNKKLRLDEGTSHALKAKDCIQKLRDVIDKVIINELKPSTYVYTPLAEDNDQEIRILVIEPGEGDDPIKCRLFPSALSKSKKRLKTKAYSFTALSYYWGGGDPIHEITITSYRTPTKRLEKLTADDADRRNVMVRIQKHQDWTEQGTFYVRSNLYAALQRFRKKNRRRSMWIDALCIDQNDHRERARQVAKMHELYMQARKVEIWLGDGTSPYSPSPEPCFRFLRKILDLKNLDSLLQDLEGNQSDMAENIKNWECILGLMRNTWFSRRWVIQELALAREAEVVYGSSKMSWPDFADAIAIFIKNYERIRPFMKMAAAGTVSYVPELSHLDAVKGMGANALVDFTNNVFRRSENKDLRQPMMTLEALVSNLLAFEAKDPKDTIYAVLSLAKDTHRLQTDSSAATKLMGLDPRLRPDYRERKSLLDVYAGFIEYCVAESKSLDILLRHWAATAKKERRLEISSQNSNAEEKLPTWIPLIQKSPYGPPAQRIQGRSNGDSFVGTSFRNSQRNYSATSELLPQVDFEESDIPPNPNTSNRKKVYSGRLFVRGLRIGTIKETTPRAAQGMIFKEALDMAGFDHECWKESHKWSPKNSRVPEGFWRTIVADRGPEGTNPPSWYPRACLECLYHLKENGDLRPNDVIELANAPSLVKSFLERVKDVIWERLFVRVKLDGDQEKYTYGLTPKEAQRGDIIGVLFGCSVPIVFRQQGSGDATYFEVIGECFIYGMMDGEAVAGMTWEHPYSDAEAFELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q3J0</accession>
    <name>A0A3D8Q3J0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carboxy-cis,cis-muconate cyclase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_13188</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000027">
        <property type="protein sequence ID" value="RDW56439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q3J0"/>
    <dbReference type="OrthoDB" id="1715191at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000244">
        <property type="entry name" value="Carboxy-cis,cis-muconate cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF4">
        <property type="entry name" value="CYCLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW56439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="361" mass="40466" checksum="CF97547B8CBBE863" modified="2019-01-16" version="1">MVVHHMMVGTWTPPGAIYTIAFDDEAHTLKLVKKTEIAHDESISWMTFDHKKKNIYGAAMKKFSSFNVANPTEIVHHASHPIGGNPLAQNADTNTRAIFILAAQKPPYNVYGNPFYNHAEYGNVFSVNSEGGIEKNIQNYKYGPKTKIHGMVFDPTETYLYSADMGENKVWTHKKDPETGMVELVGSIEAPSPGDHPRWVAIHPSGKYLYALMEAGNNLAVYVIDEQTHLPVYTHIRYPLIPPGVKNPKMYRSDVVFLSHSGKYLYATARSNDFGITGYISAFKLNDVGVIERQICMNPTPTSGGHSNAVSPCDWSDEWLALTDDQVGGIEIYRWNEEFLCRVARLDITDPGFGMNAIWYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q463</accession>
    <name>A0A3D8Q463_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_13121</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000026">
        <property type="protein sequence ID" value="RDW56480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q463"/>
    <dbReference type="OrthoDB" id="5407225at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW56480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="149" mass="16606" checksum="F6A1D2BC8798B0E3" modified="2019-01-16" version="1">MSVNVDINTRLPGWQLLVRSCLALLLGGLANFFVKLYRIRSKFQRMQNDGLPMPPHHPVFGHLKLVAGVMSKVPRNAHSSVLSHQINRLFPDLGATFYIDTWPFGPPLLVIAGPSTATQALSLPKYHRLRQYMLPMTGGNDLVTMEGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q5H6</accession>
    <name>A0A3D8Q5H6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD dependent oxidoreductase-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_12987</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000024">
        <property type="protein sequence ID" value="RDW56920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q5H6"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF15">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="11"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW56920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="490" mass="54137" checksum="712995BE1DF9BEA4" modified="2019-01-16" version="1">MAVPPSKISPIIIVGAGAFGLSTALHLAYAGYSNITVVDYQPYDEIAYSTALGADAASADMNKVLRLSYGSEILYQRLAFDSLEYWNAWNEQISQSAPEQLPKGLKPTDKIWNNCGYLRMSLDGRLSEHEEATLSNLTAEGLRDTQYILGNRNDDARAWSKGLTRKFDPMLRKARGKSLTGVFDSTAGFVEASKCCTWAMHLAKQAGVKFVLGQQGRMTSFLKKNGRTRGIFTADGRRHKADLVVLAAGAWTPSILPSIAPLLETTAGSVAYFQLPPQEQAPELWERFSPANFPVYAWGGWSKGAGLGGFPRTKTGVLKIGFRGTKYTNYETVVDEKGDEHRISVPKTAWWPRAATPQITKQAIVEIKEFVKENLPELADLGIAGCRNCWYIDSLDNNFVIDWVPDDPGLVICSGGSGHGFKFLPILGREVVKIIENPAQKNEYSQMWAWRTQINGPRNGLEDGEGGPRVLSKQKMATKEDWKFSEIAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q6V6</accession>
    <name>A0A3D8Q6V6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_12828</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q6V6"/>
    <dbReference type="OrthoDB" id="5423818at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF3">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G03310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="59"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW57378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="395" mass="44403" checksum="D4D907EB0967F115" modified="2019-01-16" version="1">MDPLGEKAPRNPTRQHDPNSGPFLCKICSKAFTKRPSRNRHVLYCRKKLGDNLPVLRKSCAPCRKVKVKCNSEFPPCGRCRDKDLACVYELTRRSESVAQQPTFPTLDEPATGGTSLVEIPALGGQNDISWDTSLSCNNPALLDNNVDHSGSLAVVPDLLSQNTAFDWEPGAWYMEELESSDAAVNSRSDSLGNDLSFDWMSPGPFPSLIIESTFSTPADCMFHTPYLVLRPMDYDYLSHSVVSPRSPFTHTQLSNGSQIGRTFLMQSIKSYTTLLATSTLPPFIHSISLPTQGPSLPFSAPLEICKSIMSLYTTKTVATSPFIWRAIMMEKDRFIKEIEDADEWTMLSMLQAITLYILLRIFDQDSFSIDFDRELAHAMTVRHFTLESEYRTWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q7P3</accession>
    <name>A0A3D8Q7P3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Clr5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_12620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q7P3"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025676">
        <property type="entry name" value="Clr5_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF193">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14420">
        <property type="entry name" value="Clr5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Clr5" evidence="4">
        <location>
            <begin position="10"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="452"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="863"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="902"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1048"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1083"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1118"/>
            <end position="1150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW57819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1227" mass="136021" checksum="42BC500C4363799B" modified="2019-01-16" version="1">MVPVAKKISKQEWDAHKDTILDLYHVRNLPLCKSDKGESVQSILETEHSFIASRNQLDAYVRSLERPKRLKKGEWRAVHTKLDELLALGIEARVKLSGEVLSKERLQRSKRHAFLGHEHLIKSTSAEHALPRPDSLVIETQGVDGEWSRYTSENRLVRVNSPPSANDLAILELEAEESVPNYNALHPLGLEALSQFRNTASDGHPVWGQESSPPLQHMNQCQPFSTFNYQRQPFGSPRFSGYNPHLSLDFELSGESLGNWLESSTLEDPYTLQYWDRELTLSRFRTTVLATPTWSSHSESPSIRYPRSSARDATLDNPLHASPMSLSLLHESIPQDDFEVTGEIVAENANSDSSFYNMLLYSIANGFAGLRDLPDGAIFKMLQKQNHLSSRIMECLWICPSAQAKCLVDNLFRAAVEACDEEAVKAILQATCDSQNAIDPNGIVCKIYDDDRSYTPIELAAKHRHLGMVKTLLAAKADVNKTYAQRDSSECGALELAVHKWGDSEAVDMTLVKTILDGNAEVRVDLIMVVVRWGQTDILQELFSRFSPARHRDFFQSRKRPLADMLVKEKLAEIAEYLENDLATSFIKRIFEYCQSENCYRCLQDHQKLMEETLCSGARKANVNLVELLLPHTTMKTGGLTGAVRSGSRQLIDIFYLHGASLGGPTCYLDEIQADEYHIPKPLPTTPLAEAVRSQDMDLVHEFERLGALSHMDQTRHFEATIIAAAEIGNCEYMTKLLQQFPKKRGIHLWLALIVAIRKDRTEAALVLLGIGAPVSSVEPTYEPTPEFMHGLHLFSPLVEALQRQNKAIVDAILEIGVNIRHESRVMESRAMESRVMEYAGLWGDIPVIEDLINMGANINGGQNITALTAAVGSRNKGLVKLLLERGASPSAKASPIVTAVRTVTPLTRAIENEDDDMIQFLISCGADPADEDAFCSVIKWHGELFDMLLRAFSSKYPSGKLSFGGAPLILAVKIGDITLLTRMLAAKFDVNGFCEQGECELTALGFVIRHVKRADERSPIIRELLNHGDPNSIVLRPGEYVRLKRIYSKTALLVAVESRSEYIVELLLAKGADIHRPARRGLKRTPLQRACEVGSFKMVKLLLEHGAGVNEEPAQRDGATALQLAAISGSIRIAELLLSRGALVHAAPAKVGGRTALEGAAEHGCVEMIRVLWNASAGAGFTLEMIEKAKRLALDNGQRGCAEHLNSLSLSIPSAPLLEMAPIHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q904</accession>
    <name>A0A3D8Q904_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q904"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02231">
        <property type="entry name" value="cupin_BLL6423-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047142">
        <property type="entry name" value="OryJ/VirC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156:SF2">
        <property type="entry name" value="CUPIN TYPE-2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156">
        <property type="entry name" value="SLR2101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="91"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW58291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="189" mass="20838" checksum="8268AED45F0E4EEF" modified="2019-01-16" version="1">MAQVTKEPLSDLPQLRRLVTSHNADGKAIVQSAQDFAWQKLDEDKMAFSVVFSTSCSPPDLNNEVDIITHDKLMEKGVGLVNPNGSIIRCVDFSPGYRCGMHRTQSLDFGIVLEGSIDMVLDSGDVQRMKRGDVAVQRATQHQWVNNSTTEWARMMFVLQDCKPLEVGGQKLGEDLGDGLDFLPPSGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q9M5</accession>
    <name>A0A3D8Q9M5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_12248</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q9M5"/>
    <dbReference type="OrthoDB" id="5213892at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF26">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW58318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="541" mass="60858" checksum="F95B1DBFD9A5F063" modified="2019-01-16" version="1">MAKSTDFSAVSPDTPWDNKFSNYTLEPLATPPMNMHSPNDTRRWSSGPSPIDDLPGSYYSYSSPEVHDDQMDSFSRREIEQKYTISDSELSDPEMCSMTTRETDIMALYLDTVFYETYPFHRLRKNSLEYRDWHLALPIFQGPTQRACFGVSRQHGNELAAGGGTSNSEYLEGRSSGLQATSYYICAIESLGSELAHWIQNRGNKCPWERREKTTEILFCILQLIIFEVYQDGDAGLWKTHFQGVSDLITDLPPWFSVSSSVPTSSSPTISQCTTSLQNPTNLPPSPAGSVYGSCSQLYCSHPHHTHTQTVSCKFVYLSFIYLDIIAASSTRTPLTLSIDHLTLLHSSQGEQNPSASNICCIQLFGLEELALVNLCHVVQLETLKNEGIRTADASMVRLVEQGAVIQAQIQQSLWVSRMYVISGPPLPQQQTTWPKSYELSTIRSEIYAHATLIYLHILLSGPLPHLLEIRTSIQAALFLFKMLSPQHRQLRGLRWPAAVLFCLAQEDERVWLEEALASKWGTMIARESSKSTDWAHLPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q9T0</accession>
    <name>A0A3D8Q9T0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_12347</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q9T0"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="6">
        <location>
            <begin position="85"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW58417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="558" mass="60982" checksum="60A7FE8D0473CC9C" modified="2019-01-16" version="1">MTVSTIKKPADFAPAIQKKNAEQLELIPLEWRIPAEQLPSDDQLRVVDVTSTCGVLSADELEIIFKDSSELSELLSTGKISCVVVTTAFCKAAAVAHQVTNCLTEIFFAQALQRAKELDDKYASTGLAGPLFGLPISLKDQFEIKGTECNMGIVSWIGDISKENSVLVDILEQAGAITNVPQSLMFAESDNFVYGRTSNPFNRNLTPGGSSGGEGAVIAMRGSVIGVGTDLGGSVRIPAAYNGLYGLRPTLHRLPYAGARNTLLGLESVGSALGPISNSISGITAFTKAVLDFNPWLLDPKVPEIPWRQDMYELKHLKASSGEPRKPVFGVMRWDEYIMPWPPLQRAMEMAVSAVTRAGYEVIEFPCPFSNALAENIINRIYSSDGSTDLKKTFEKSGEPWHPMISTAEDTPHLTVYESWQLNQEKYKVADAWLKAWNETANKTSTGMPIDGLLLPPSPNVAHLHGAWPRHIIYTSLFNMIDYPGIVIPVHSSVDPVLDPIDKSFKPANDRDAYIQALWIDSPETYAGAPITVQLVCRRFREEECIGLAGVVVDALNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QE63</accession>
    <name>A0A3D8QE63_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Glycosyltransferase family 17 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_11732</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QE63"/>
    <dbReference type="OrthoDB" id="6474464at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003830">
        <property type="term" value="F:beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006044">
        <property type="term" value="P:N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006813">
        <property type="entry name" value="Glyco_trans_17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12224:SF0">
        <property type="entry name" value="BETA-1,4-MANNOSYL-GLYCOPROTEIN 4-BETA-N-ACETYLGLUCOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12224">
        <property type="entry name" value="BETA-1,4-MANNOSYL-GLYCOPROTEIN BETA-1,4-N-ACETYLGLUCOSAMINYL-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04724">
        <property type="entry name" value="Glyco_transf_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW60126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="393" mass="46054" checksum="4239B0579EC1131C" modified="2019-01-16" version="1">MPALLGFSEKARWNARGRNRRQGPLKLLLLVFFFWIASRLCKYAAWKRNTIVPQDVKFAVDPNLPTPDPASSPAHYGSVTKASAQNQCSAHGWRPFPMQTHRRKVYDLFMINNELDWLEIRLHEMHHYVDYFVILESATTFTGLPKPLTLKENWARFEKFHSQIIYHVLENPPMEVHITWVHEDFQRNAMFKQVIPFLKNEQAANLGDVILVSDVDEIPRPAALELMRYCDFPRRLTLRSRFYYYGFQWLHRGPEWAHPQATTYQGPSRTILPADLRNGEGGNRFLNWFEKSDLFNAAWHCSSCFSTVDEMLNKMSSFSHTKLNEEKFRNRARIVDRVRNGLDLWDRKGEIYDRVEKNEDVPSLLKENTARFAYLLDRDSPTAGFQDVGPEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QFF8</accession>
    <name>A0A3D8QFF8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COP9 signalosome complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_11760</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CSN4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QFF8"/>
    <dbReference type="OrthoDB" id="295656at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF2">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="PCI" evidence="9">
        <location>
            <begin position="192"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW60154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="410" mass="44934" checksum="8A4072388AA61E00" modified="2019-01-16" version="1">MASPKVAQALQQITNQTDQQQGYEALLQSTQLPNDLSSILDSIFASSLGTVATRSLLAVFIAALKTIPSNETKIAVGQHALDVLQAQASSFEEQNASLREIMADAYEEDEDHLAAANVLAGIPLESSQRKVTNEDKVRFWIRITRNYLEVDDTTLAEQFLNKAKNVIYTVQDRDLNLLFKLCQARIQDARRNFLAAAQGYQDISFMTVIAEEERLHTLSMAIKCAVLAPAGPARSRALGRLYKDERAATLEEFGILEKMFLDRLLSPTEVAKFAEGLAPHQLAITGDGSTVLAKAVVEHNLRGASRLYSNIGFEALGLLLGLDGDKAEETTARMIEQGRLVGRIDQIERVIWFEGGEATGEKGSGRAAGVVGKELRRWDANVRDLAEEVEKVTSALQTAYPDFVAANLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QFY4</accession>
    <name>A0A3D8QFY4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_11930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QFY4"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056599">
        <property type="entry name" value="AAA_lid_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF4">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23232">
        <property type="entry name" value="AAA_lid_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="654"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="887"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW60324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="907" mass="102141" checksum="88EFCB88C6FBC6B9" modified="2019-01-16" version="1">MEIGNGPCRNPLSGEEDATRFGPHHTTSVLTSADISQPSADGNDKRDESTDDVENLETMPDGASSQQQETKYEKEKEGENGEARTLDSENPHLTYWCPASGSPHSTYLDGYYDSCPICGQSLARPEFPSAKEQELQVRGSKIVHEVEYRDATNLIIDSIEWGRPFDLEQETNKKSKFQKRTTNTTVFKVVHVLGTSIPGDDTRSISGRRTILDDGIIGNPRVAVSVLNIKLVILSQPLINALQDIATYDTGLELNGGNVTLQEPYLLVAYHISELESFKLNLAKRTQEDSTTTQAANIDGVDKDVVVEHIGYLLDYMHSVFGDSIRQELTRYTDATPSCTYRMIWLLFKPGTTVYVKEEGKVNAYVIDSVDTGDAFLSSPSKVVKIKLWNLDFDGRNITRVRHNVSLEQFDGQQPITSLPVVPGCYWDAEDGGKMRTTLEAEGKKWFKLLSGDQVYYSGELANRKRQTVDGRAYVDPCAYFDETAWPELDRMVPEFTDTNNSTGSLDEIGGAVKGCLCPSCSRRRKITRSEMGISTTVSASKGHLNPPWGQYDNIDTNITKSLELDGSTNPDHRYLLCSRWLGAFMFKTRTWQRLDVTYCQEPKPNRTPFERLVMDEGQKLMIKSLVYKYTDPRFAGSNAQQVWGADFIQNKGDGQIFLLHGGPGVGKTFTAECIAEFTGRPLLALTCGDIGTDEVAMEKSLGKWLTLAHNWGAVMLLDEADVFLETREKADLKRNSLVSVFLRQIEYYQGILFLATNRVGQFDDAFVSRIHVVVHYPDLSREDRQKIWGQFFDKLEDEIGDTVRIDKRARSYVLNSEFEWNGREIRNSFQTAVALAEYRFITKPEVEKNKGDVAVLTSADFEQVCRMTVKFKKYMNTVHGGTEQERAQLSRFRVGPEEDLDNSRAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QID8</accession>
    <name>A0A3D8QID8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aspartate--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Aspartyl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Probable aspartate--tRNA ligase, cytoplasmic</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BP5796_11350</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QID8"/>
    <dbReference type="OrthoDB" id="372395at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000038">
        <property type="entry name" value="Aspartate--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000132">
        <property type="entry name" value="Aspartyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF1">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 16" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="15">
        <location>
            <begin position="258"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="53"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00070516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDW61458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="570" mass="62836" checksum="AFEA56F04D47C5FB" modified="2019-01-16" version="1">MAEPAPTAAPQDPAVAPAAAPAAGEEGAVSKKGAKKAEAKAKKEAEKARKAAEQAAKQAAAGGANSEDLAKDNYGEIKHTTRLSSENVHLREITEAHLGKTIKVRAWIQNARMQGAKMAFVELREEGNWTIQGVVGASPEGTPVSRQMVKYIGALKLESFVMVEAVVQKPLEPVKSTKVSNFELHLTKLYLVATAPEMLGLSLAPASRAVGRLDEEEVKEEGVEGLSITDTPVASLAVHLNNPAMHKRAPVSQAIADIRIAVEDLFCEYLRARRFKRFHPPALIGAASEGGANVFSLPYFGQNAYLAQSPQFYKQFEIAGGRKRVFCVGPVFRAENSNTPRHMTEFTGLDLEMEIDEHYHEVLHMLEGVLLHIFRGLAKDYSEEIELVRTVYPSDEFLLPEPGKEVRLTFAEGQKLLREEGPEEYRNVSDDEDMSTPQEKALGALIREKYKTDFYVLDKFPVEARPFYALPDPENPKVTNAYDFFMRGQEILSGGQRVHLPHELEATIRSKGLDPNQPGIKEYVDVFRSVGVPPHGGGGIGLDRVVAWYLNLPSVHLVCDYPRTPKRLAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QIH0</accession>
    <name>A0A3D8QIH0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD-binding FR-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_11524</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QIH0"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000013">
        <property type="entry name" value="NADPH-dependent diflavin oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000032">
        <property type="entry name" value="NADPH-dependent diflavin oxidoreductase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF10">
        <property type="entry name" value="NADPH-DEPENDENT DIFLAVIN OXIDOREDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding FR-type" evidence="8">
        <location>
            <begin position="216"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="114"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="130"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW61632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="630" mass="71953" checksum="4F0E2A93269949C8" modified="2019-01-16" version="1">MTDQVHGQQHQRSALVVYGSETGNSEDAAHDLDRMLERLHFVTRVCEMDRIEILGANEIYPRGEGDEQHEEGIDGTFLNWSADLRKHLLSAFPLPDGLEPIPEDAFLPPKYCVSVDASSSSSTTTERRPGQQSRFASKPSQDQLATLKSSTSRDHTNPDPSGEELPDMSTLVLKKLWQEPVNHESNAEDGSQLKEPVAGDQAKDIQLPSDDCLPIPHGYEAYLVTNFRLTPPDHWQDVRHLSFIIPADIEYFPGDTMTLFPKNFPEDVQALIDLMDWNTMADIPLRFHSNLPDYQSPQLISGFELPHLFPLEKTTLRELLTHNLDITAIPKRSFFQLISHHTSDQMHKDRLLEFANPTFTDEFYDYTSRPRRSILEVLQDFPSVKLPMKYVISFFPVIRGREYSIASGGHFKESRDPRYEGMVQVHLLVALVKYRTVLKKVRQGLCSRYIASLPEGARLAVTFNTNEKFFQPAFNNPQFPLILIGPGTGIAPLHAMVWERKWLSQSSRYRSLDFGRIVVFYGGRNRNADFLYERAWEHPATNTTVYSCFSRDQPEKHYVQDLIREKGEEVCQLLDQGAIVYICGSSGKMPKAVRQALVSVLEEHKSLERKDAEERLEAMEKGGKFVQETW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QL65</accession>
    <name>A0A3D8QL65_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyl hydrolase family 32 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_10847</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QL65"/>
    <dbReference type="OrthoDB" id="202537at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004575">
        <property type="term" value="F:sucrose alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005987">
        <property type="term" value="P:sucrose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18622">
        <property type="entry name" value="GH32_Inu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.115.10.20:FF:000002">
        <property type="entry name" value="Invertase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001362">
        <property type="entry name" value="Glyco_hydro_32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018053">
        <property type="entry name" value="Glyco_hydro_32_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013148">
        <property type="entry name" value="Glyco_hydro_32_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800">
        <property type="entry name" value="EXOINULINASE INUD (AFU_ORTHOLOGUE AFUA_5G00480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42800:SF2">
        <property type="entry name" value="INVERTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00251">
        <property type="entry name" value="Glyco_hydro_32N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00640">
        <property type="entry name" value="Glyco_32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00609">
        <property type="entry name" value="GLYCOSYL_HYDROL_F32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 32 N-terminal" evidence="4">
        <location>
            <begin position="91"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW62545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="580" mass="63104" checksum="29A81F41D7ADD828" modified="2019-01-16" version="1">MLSLFSQFSIRQTSHKILVLLVLSLLGFFLFVAMRESTLWAAASTAFVSVAAATGHNYGFGTNSAVSVATTTNGSQNGASLYSGPLRPQIHYSPPVNFMNDPNGAFVDANGTWHLYYQYNPTEIVAGNQHWGHATSPDLYHWTNHEIAISPENKYEGIFSGSAVVDVNNTSGFFPNQTNGVVAIYTLNTNVSETQQLAYSHDGGYTFTKYSGNPVIDIGSSQFRDPKVIWYEDHWVMSIAYARDFVIGIYTSPDLKSWTHASNISHVGFLGLQYECPNLVKIPMDGETEDTYLLIISINPGAPQGGSFTQYFPGTFNGTHFTPFDGAARILDFGKDNYAGQFFYDSDAHTPGGEPVFVGWASNWQYTQQVPTGPLEGWRSAMTLPRTARLISNATRIGYDLVTRPYAELAPVKGAQLAHSDSVSNSSMQVNYANLTSGAVYFQVTVTNVPNNTFAMGTLNFTFTASASGETLSGGYFFGGDTPFWVNRGKVRGLDNPFFTDKFSTVYLLPETSNTFVLEGVLDRSILELELGGTGARGSELGTLLAYPEARFDALNIASAGVNEGVSVSAAVWALNSVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLA2</accession>
    <name>A0A3D8QLA2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_10908</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase G subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLA2"/>
    <dbReference type="OrthoDB" id="250802at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.2950:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005124">
        <property type="entry name" value="V-ATPase_G"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01147">
        <property type="entry name" value="V_ATP_synt_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713:SF11">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03179">
        <property type="entry name" value="V-ATPase_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="28"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW62606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="119" mass="13503" checksum="DF4A9EAA2C8B38BF" modified="2019-01-16" version="1">MSAQNSAGIQTLLDAERDAQKIVQRAREYRTKRVKEARDEAKKEIEEYKKQKDDEFKKFESEHTSGNKKAEEDANKDAENQIKDIKAAGKKGQDKVVKDLLKAVFDVKPVAPSRIEAPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLB0</accession>
    <name>A0A3D8QLB0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_10887</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLB0"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000297">
        <property type="term" value="F:spermine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000011">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF182">
        <property type="entry name" value="POLYAMINE TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="66"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW62585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="507" mass="55269" checksum="FD54ED1BBA8B2F8C" modified="2019-01-16" version="1">MSESNRHPSHSTLTLQHTPRPSQEAPRTADPEKGGSVPKTPSANDWDGPDDPENPLNWSRWKRLWHVVPPALISFTATFASSIYTPAFSEIKSDFHVGSTVAILPLSLYVLALGAGPILAAPISETYGRHVVYLISAPLGALFTMGAGFSPSIASLCILRFFAGLTFSPALAIGAGTIADVNRPEHRATPTSIYILMPFLGPSLGPVIGSFVSVRKSWRWTQWTIIFFAILSMLSLLTAQETYKKTILLRRAKRLHIPPPPSPFPTSGARIKFLISVTLIRPLHMLLTEPIVGFLSLYTAFNFSVLFSFFAAFPYVFRSVYHFSTIESGLVFISIGIGCLLAATTAIVCDKVFYQPQVVLSHAAGNNGVVAPEYRLYPAMFGSIGLPLGLFWFAWTAKADIHWISPVLSAIPFAWGNLAIFIAAATYLVDTYQALTGASAMAANGLLRYTLGAVFPLFTLQMYAGMGIGWATSLLGFVTVALMPIPWVIFKWGRSIRARSAYDTLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLH6</accession>
    <name>A0A3D8QLH6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Creatinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_10863</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLH6"/>
    <dbReference type="OrthoDB" id="2818246at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01066">
        <property type="entry name" value="APP_MetAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="1">
        <location>
            <begin position="41"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW62561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="209" mass="23580" checksum="B1817AC08642AC01" modified="2019-01-16" version="1">MSAEASEAEERQRAVYLLDAQNKAVGLFEEIERTLIRPGGRVVRSGPNTMKPYAENPPDRIIQEDDIVFIDLGPIFEAWEADFGRTFVLGEDPTKLRLRDSLEPVFLAAKTHYLANPDMTGEALYELACSLAERAGWEFGGQIAGHLVGSFPHERIPNDRITLYITHGNDQPMSRHNALGQKRHWILEIHLVDRARQIGGFYEQLLTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLP6</accession>
    <name>A0A3D8QLP6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_10933</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLP6"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008142">
        <property type="term" value="F:oxysterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000010">
        <property type="entry name" value="Oxysterol-binding protein homolog 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF184">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN HOMOLOG 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW62631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="45693" checksum="1BD7585A63383ED7" modified="2019-01-16" version="1">MPISMSSKCSPLSPKNEEFKVAPSQKNAWFQFLKSIASFKGDLSSLTAPPFLLSTTSIIEYSAYWAEHPSLLVAPANEEDPEKRALLVLQWFLSTLKEQHSSKDEAGRKKKMKPLNPFLGELFLGQWEDASGTTKLVSEQVSHHPPATAFKVWNEKHGVSVQGHISPKAYFSGTVRIDRKGYAILHIDRFNEDYLITMPKVHIEGIMTGTIAPELSGTSTIHSSSGYTALIDYSGKGWIGGTKNSFNARLFRDGNPEEPLYMVDGQWSCSMNIKEMKTGNTTQFDLRDLKRTPVTVLPIEKQGELESRRVWKKVAEAIDAGDIFAVSHEKSKIENEQRELRKKEKAEGREWPRRYFKRVEVDPVAKQLAQGLKVESDIQGNGAGFWVWDEDAMRERPDSGVFVKVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLX6</accession>
    <name>A0A3D8QLX6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">U3 small nucleolar ribonucleoprotein protein IMP4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_10952</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLX6"/>
    <dbReference type="OrthoDB" id="10253204at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000001">
        <property type="entry name" value="IMP4, U3 small nucleolar ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF2">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="86"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00040513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW62650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="298" mass="33863" checksum="56C660482E76E693" modified="2019-01-16" version="1">MIRKQARQRRDYLYRRALTLRDAEISEKRAKLRASLATGKPLDPTIANDKTLREDYKYDESKKDLTANEELDLDDEYAQLSGIVDPRVLVTTSRDPSSRLGSFAKEIRLLLPTSIRLNRGNLVLPNLVSSAQASGLSDIVLLHEHRGTPTALTVSHFPHGPTVSFSLHNVVLRHDIPNSSRGTVSESYPHLIFEGFTSRLGLRIVKVLKHLFPPREAITNKTKIGSRVVTFKNIEDSIEVRHHVFVKTGYQSVELAEVGPRMTMRCFEIRGGTLDNKDGDVEWRMNQYTRTSKKKDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QMV1</accession>
    <name>A0A3D8QMV1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_11086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QMV1"/>
    <dbReference type="OrthoDB" id="409136at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW62784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="269" mass="30597" checksum="11CD976B19159CAE" modified="2019-01-16" version="1">MSAPNSVDFYLEDEHQWNHIFVQPPRPAQLSQEPNLSTPQQHVHAATPRSGRRTSSSQASTRSSFVSRSDSDFSVMSAATSASSVSQTPFNINPVNDDGNNLPCEFVFLGCEQTFHPEEVEAWISHHEAHFTPHGPPRTSICTICDDRTARFSDSSDVYLNWRNRMIHIAEHLSTGESHLRPDFWMIDYMYEIGKIEKKVYEYAMLYTERPACSILVAPDFVPPEKKEKQERASREVHDQAREDRKRAREKTGRTGGRSSAGRTNKGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQC1</accession>
    <name>A0A3D8QQC1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 15">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 15">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BP5796_10380</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 15">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 15">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Endoplasmic reticulum membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 15"/>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW63878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQC1"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031502">
        <property type="term" value="C:dolichyl-phosphate-mannose-protein mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23283">
        <property type="entry name" value="beta-trefoil_MIR_PMT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000034">
        <property type="entry name" value="Dolichyl-phosphate-mannose-protein mannosyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF50">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 15" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="244"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="274"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="603"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="645"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="674"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="703"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="327"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="404"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="17">
        <location>
            <begin position="473"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="768"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="831"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="911"/>
            <end position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDW63878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="944" mass="105425" checksum="5375C1863F8A7A4A" modified="2019-01-16" version="1">MARVQKTAYEALSKESESKAAVKKHDDYTSDGVEDHDIFLLPGSDYQVMAVLTLLGAIVRLFRIYQPSSVVFDEVHFGGFASKYIKGKFFMDVHPPLAKLLLTLAGWLAGFDGNFDFKDIGKDYLEPGVPYVAMRMLPAVCGILLVPTMFLTLKASGCRTTMAALGSCLIVFENGLLTQARLILLDSPLMIMTALTALSFTSFTNQHEQGPRKAFQPSWWFWLAMTGLGLGATASVKWVGLFTIAWVGSLTILQLWVLLGDVKTVTPRLFAKHLVARIFCLIVIPVTFYMAMFGIHFLCLQNPGDGDGFMSSEFQATLNSKSMQDVPVDVAFGSRISIRHHNTQGGYLHSHNLMYPTGSKQQQITLYPHKDENNVWIAENQTAPLDSNGQPINGSRAYDNISPPTFIKDGDTIKLYHITTDRRLHSHDVRPPVTEADWQNEVSAYGYEGFEGDANDFFRVEIIKSMSDGLEAKERLRTIQTKFKLVHIMTGCVLFSHKVKLPDWASEQQEVTCAKGGTLPNSVWYVEQNEHPQLGDDAEKVNYRNPGFFGKFWELQKVMWHTNAGLVESHAWDSRPPSWPILSRGINFWGKDNRQIYLIGNPVIWWSSTLAVAVFAIFKGIAVLRWQRGFKDYDNTVFKRFDYEIGTSVLGWAFHYFPFYLMQRQLFLHHYFPALYFAVIALVQTYDYVTARIPGIGLRERPLFGKLGAVVFLSLSVVAFGLYSPLAYGNPWTQAACNKVKLFESWDWDCNTFHTDYSQYNTQSVNANVHKTDSPSSPTSAAAPPPIEVEPAGGEQKPIMEEAPAVSDAPEMSSAPPLPYGHSILSREEKVEYRDQDGNLLDPEQVKSLEGKVSFKTRYETRTRMVDAAGNEIQPPDDFPVAPPHPDVEGQEPETVGKPESSNAESPAAQKEVKADESKEQSVLKSDSGAAKPASEGNEATASN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQP9</accession>
    <name>A0A3D8QQP9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidyl-prolyl cis-trans isomerase-like 1</fullName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_10631</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQP9"/>
    <dbReference type="OrthoDB" id="10264753at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01927">
        <property type="entry name" value="cyclophilin_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000003">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD repeat-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000450">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD-repeat protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="63"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="107"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="11">
        <location>
            <begin position="472"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00040798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW64129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="618" mass="69294" checksum="F55E7CD756D4CAE4" modified="2019-01-16" version="1">MSAEDPAAKSNKRSRSVENDSSSDDDMGPQLPSSAVPKKKRRVLPYEKLYISALPTSARYSKSLMHKEQLSFVTMTPLTDFLITSSVDGVVKFWKKGSEGIEFVKEFRAHVGEIKSVSVSADGRSFATAGADKTIKIFDVITFDLLSMLSLEFTPKCICWIHKRGASLPLLAVSDEVNHNVRIYDGRGENQDPVHTITGLHRSVVSLMAFNDAYDCVISADENGMIEYWRPGGNYEKPDNVFEYKSSTNLFEFKKAKCTPTTLTISPSGHQFATFSFPDRKVRIFDFPTGKLYRTYDESLQIIEEMQQAGTGLQKLEDVEFGRRLATEREIDGPALRNKANVIFDETGHFIIYGSMFGTKVLNTYTNRIVKVYGKDESFRPLNIAIYQGQPQKKGITTVAMAASNNPLLQQSETRDPILITTGVGKVRFYMFTNDEEISKSERDVQNEKPTTNARKAVEAKIAETGTAAIIHTSYGDIHIRLFPDAAPKAVENFVTHSKQGYYNNTIFHRVIRKFMIQCGDPLGDGTGGESIWGKEFGDEFSTLKHDKPYTVSMANAGPNTNGSQFFITTEKTPWLDNKHTIFGRAIQGLDVVHRIENARAYKEKPEEDIKILSIEVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QU64</accession>
    <name>A0A3D8QU64_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Histone-lysine N-methyltransferase SET9</fullName>
            <ecNumber evidence="12">2.1.1.372</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Histone-lysine N-methyltransferase set9</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">SET domain protein 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BP5796_10031</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Histone methyltransferase that trimethylates 'Lys-20' of histone H4 to form H4K20me3.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(20)-[histone H4] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:64456"/>
            <dbReference type="Rhea" id="RHEA-COMP:15554"/>
            <dbReference type="Rhea" id="RHEA-COMP:15998"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.372"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.372" evidence="12"/>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QU64"/>
    <dbReference type="OrthoDB" id="6627536at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140943">
        <property type="term" value="F:histone H4K20 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10524">
        <property type="entry name" value="SET_Suv4-20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1700">
        <property type="entry name" value="Histone-lysine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041938">
        <property type="entry name" value="Hist-Lys_N-MTase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025783">
        <property type="entry name" value="Set9_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039977">
        <property type="entry name" value="Suv4-20/Set9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977:SF4">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE KMT5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12977">
        <property type="entry name" value="SUPPRESSOR OF VARIEGATION 4-20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51567">
        <property type="entry name" value="SAM_MT43_SUVAR420_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SET" evidence="16">
        <location>
            <begin position="115"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="256"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="472"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="640"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="290"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="394"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="482"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="640"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDW65339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="682" mass="76825" checksum="DCB5891F7A700B9D" modified="2019-01-16" version="1">MPARPSSPKKQRLTLAQLHSYDDILTDALVDHVYYWTSIRKNRIAYHPSRGIREEDVSKILQNTVIIEKNTAKAEAQLMALPGLKKFADNLKSLKEKEDFRQHLRRYINIYLPECPFEVASTNRFTVVTHEAAITARRFIKKGEIIRYLCGIQVIMTPEEEAQVKKSRRDFSIVVSSRNKSASLFLGPARFANHDCQSNAQLQTTSSNGMEVKAVRDIELGEEITVTYGENYFGEDNIECLCKTCEELCQNGWQAEEDEDGNKITPKPSIESEQQAQRISHGLRKRRRLSTGSSRTESMTPDISNIRPVISKRTPKSRSRFQCLKGSTQSQTPERPNFQPRKRKRDFGDSGADSVSPKKQRQIPSVVKTEELEVPKLEPLPAHNEDVSRDESISEPTSVATPESSAEHPTETDNTSVDDDTIVVQRPSANEEIPTESTVLEMLGESEPAAASCPILVGPSTSADHPAIIEETGSLPSVEGDESSKSNKDSPRTKKKAALPVPNTDYDHAPAVRIPGDYLYNDALLAEPTMAWINCTRCDEPFVQQNSYFTKSSCPKCERHSKLYGFLWPKTDREGSDDEEERILDHRTVHRFIRPEEEKLSRKRDQAAIEQHASRALSIAIEQEKIKKWNAGSGWELSAKEKKKLEKAVSKKLGKTEKEKEGVSKKQSKQERANPGKLKGGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUA1</accession>
    <name>A0A3D8QUA1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_10071</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUA1"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF25">
        <property type="entry name" value="QUINATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G12950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW65379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="458" mass="50680" checksum="DE32C6A55D9B7B9F" modified="2019-01-16" version="1">MIPECGVLTLASFVHDFGYSKAHATRVNSLAVGLQQAGAFVACIAIWPITDKLGRRKSLMISAAVFCIGAIIETINTHSMAAFYVGRVVAGIGLGSATVVVPMYSSEMTPKDLRGQIGSFFQWFYTFGIFVSYWVDYAVAKRNHGTSQWQIPIGLQILPAALLGLGMLTLKESVRWLTRKGRHDEAWESLKWIRADDSQTTIDEMEEIRVGVDIERRATEGLRWRELFERENFKRMFTASCVFTAQQATGATAFAYFGPQYFKLLVGAGDKDLLLTAIFGAIKVVACGFFVLILAERVGRRNVLIWGAAFMAACQITTAAVVKTKPVPASGVITSSGIATVALIYMFVIAYNLSWGPLPWPYVSEIFPTRIREPGIAVGVASQWLFNFVFSLTTPYMIANLGWGTFLLWGIFDAVIAVITFFFLRETKGLSLEEIAHNNFAVAKDFEAEHSEPPHDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUQ7</accession>
    <name>A0A3D8QUQ7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxidase</fullName>
            <ecNumber evidence="8">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_10103</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="8"/>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUQ7"/>
    <dbReference type="OrthoDB" id="2859658at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00691">
        <property type="entry name" value="ascorbate_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000009">
        <property type="entry name" value="Ascorbate peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000005">
        <property type="entry name" value="Cytochrome c peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002207">
        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF36">
        <property type="entry name" value="L-ASCORBATE PEROXIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00459">
        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0349">Heme</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 8 11" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="10">
        <location>
            <begin position="71"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="273"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW65411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="324" mass="35895" checksum="793B4A1E41605103" modified="2019-01-16" version="1">MSKMGDFGAVKKDIEALMHQPEYDDGSAGPVLVRLAWHSAGTYDAETDTGGSNGAGMRYEAEGGDPANAGLQHARVFLEPVKAKHPWITYADLWTLAGVVAIQQMGGPTIPWQGGRTDYVDDSKIPPRGRLPDGALGADHLRFIFGRMGFSDQEIVCLSGAHNLGRCHSDRSGFDGAWVNNPTRFSNQYFRLLLSLQWRKKKLSNGVEQFVNFDDDTGTELMMLPTDIALTQDPIFRQWVIKYADDKELFFKDFSSVFSKLVELGIQRDENGHITNVDNEKGGYHSAPKKKATPGNPAKSTDDKSEPSEAEPLQKENQAFRSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QY49</accession>
    <name>A0A3D8QY49_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome c oxidase assembly protein COX16, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Cytochrome c oxidase assembly protein cox16, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_09458</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the COX16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QY49"/>
    <dbReference type="OrthoDB" id="5516033at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020164">
        <property type="entry name" value="Cyt_c_Oxase_assmbl_COX16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130:SF14">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX16 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17130">
        <property type="entry name" value="MITOCHONDRIAL OUTER MEMBRANE PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14138">
        <property type="entry name" value="COX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="31"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW66709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="115" mass="13397" checksum="B11F6E0B06FECBA2" modified="2019-01-16" version="1">MAVFQNKKFRGSVEANTVATRYRSLLARHPFVMFGLPFIATMVAGSFFLTPATAIRYEKHDRRVRQMSKEEELGIGKDGRKVDMKEEYYRLAAKDLDDWEQKRVKRLPGEHDGKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYM2</accession>
    <name>A0A3D8QYM2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_09645</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYM2"/>
    <dbReference type="OrthoDB" id="27603at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035974">
        <property type="term" value="C:meiotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008467">
        <property type="entry name" value="Dynein1_light_intermed_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022780">
        <property type="entry name" value="Dynein_light_int_chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688:SF0">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05783">
        <property type="entry name" value="DLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="414"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="14"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW66896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="462" mass="49889" checksum="73753589F5452109" modified="2019-01-16" version="1">MTSNNRTSTYTVSSDHDRSTTSDSKKDMWSSMLDSVASGKRLPEKNILVLGGTSDSQKEFLESLTVEDGKRPQDRQSAKQPPIANDFALGYTYQDVLDADHEDCKDKMEEVMVSWRDRGRGANSLDGGGNSIAAEGEVSLPLGPGEWEEPLGLPLSVSDQIETLERERGWREEDFDFVLQSLRTVLLKHGASLIYTIPSVASPIQSLVHSSLGIHSLIKKHPLKHNLIDRDKIVVPPNWDSWGKIRVLREGFDVEAVNKGWSLDIDAPVGSVSNGQANGAGSEDGHEGLSEPVQGSAVASYEEIIRDPSLDALQAANSEGNGLKLEISSLDAQEFLAKQLEVLDKIRQTSDSGMDSSRLARGLDSSISAIEGSEDVQTDQGRVNEHIGPVQFNMGGIQVDADDMLQRLKDRQMYQSPEPSTPGGSVASPDGKSQNEALSAFFAGLMKRGGGSASNSPKPGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYM7</accession>
    <name>A0A3D8QYM7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYM7"/>
    <dbReference type="OrthoDB" id="10346564at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW66781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="370" mass="41098" checksum="2334DE02D7E4DFE2" modified="2019-01-16" version="1">MPTKDYDGRGTYAQPNQKPKDSEQATEQVANHCRNCNVTNFQNYNTMTIILNQYSTPEYTSAVPTQHPTNNPVAVSFTGKGSEESSASRSDQGTKRKMVEVDRVQGVPPDSQLYGAFSPSPKRRAVFADSSAATTAPQASRDTTYARATDLRSLGDSTTLANFSEPLLNGETSRSFVDAEGETRIDRNTHSKKSLRGEVMDSTSAKQKATQGHHGDTQNVRESLGNRVHQYPHFGLDQDPSLLDDFEFIVNPPPDIGVKEQEMAETTVPRLLEDTMEGQIRRCDVERVAKTFTFPDFVKFFGFSNPIVTKAKISQAILPSGSKYEVFIIPLEAAYLIGTFVVFRKTRVAVWYAPWTNAKPQVSLTCYRSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYY9</accession>
    <name>A0A3D8QYY9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methylcrotonoyl-CoA carboxylase</fullName>
            <ecNumber evidence="3">6.4.1.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">3-methylcrotonyl-CoA carboxylase 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_09639</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>3-methylbut-2-enoyl-CoA + hydrogencarbonate + ATP = 3-methyl-(2E)-glutaconyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13589"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57344"/>
            <dbReference type="ChEBI" id="CHEBI:57346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AccD/PCCB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.4.1.4" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYY9"/>
    <dbReference type="OrthoDB" id="439921at2759"/>
    <dbReference type="UniPathway" id="UPA00363">
        <property type="reaction ID" value="UER00861"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905202">
        <property type="term" value="C:methylcrotonoyl-CoA carboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004485">
        <property type="term" value="F:methylcrotonoyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000004">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000007">
        <property type="entry name" value="Methylcrotonoyl-CoA carboxylase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045190">
        <property type="entry name" value="MCCB/AccD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855">
        <property type="entry name" value="ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22855:SF13">
        <property type="entry name" value="METHYLCROTONOYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="7">
        <location>
            <begin position="69"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="8">
        <location>
            <begin position="332"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00026116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00031404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00052347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW66890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="568" mass="60859" checksum="1B2AB44DA2C2C1EA" modified="2019-01-16" version="1">MSTYRASRHVLRLAHCNPRAGRSYLQPINGTASRGVATHFPPHQANAISALPTTIDPSSEEYKENAKQMDEVMSSLEELTRRIQRGGPENARAKHIARNKMLPRDRVTALIDPGTSFLELSTLAGHEVYSEEVPAGGIITGVGVIEGVTCMIVANDSTVKGGTYYPITVKKHLRAQAIAQENKLPCVYLVDSGGANLPHQADVFPDQGHFGRIFFNQARMSSLGIPQISVVMGPCTAGGAYVPAMSDESIIVDGQGHIFLAGPPLVKAATGEVVSAEDLGGGKMHTSVSGVADYLAVDDAHALILARRSISNLNWPKKTFPPPGSYEEPLHDPEELVGIASTNLRRPLPIHEIISRIVDGSVFSEFKRDYGSTLVTGFAHIYGHKVGIVANNGILFSASSLKGAHFIELCCQRQIPLIFLQNISGFMVGTDAEREGIAKNGAKLVTAVACANVPKFTVVVGASNGAGNYGMCGRAYSPRFLWMWPNAKIGVMGSEQLTAVMETVGKAVDPELKARIEKESEAVFSSARLWDDGIIPPSHTRKVLGLGLMAALGGKNKAVVTKFGVFRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYZ2</accession>
    <name>A0A3D8QYZ2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_09771</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW67022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYZ2"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11059">
        <property type="entry name" value="CYP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37471:SF1">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37471">
        <property type="entry name" value="UNNAMED PRODUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW67022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="967" mass="109699" checksum="0440FD4C93809885" modified="2019-01-16" version="1">MLDAVNPTLLGLGILVLLAFHTFVLSPFLALKHVPGPTTFALTRWRLALEDWRGTRTRKIDELHKQYGPVVRVGPNELSFNSLSALKTIFGAGSGFERTSFYRMFDVYGKQNLFTFESPKAHGERKKLLNHAYSKSSILKFSAEGVEDRVWEYMQLLEKDPATTSEIFSSLHYYSLDNITHFLYGKDFGGTKALRGSIADQELIRDVLDPSRRKLSWFAVHFPRYTKWLMTRTGYMEKAVAKFGLLPQKKPVVYTGIRRHALEAYNRFSHAATSNKSNADPSSIIGKLWKYHISQVANGLDDMDIASEAADHFLAGVDTTSDTLMFLIWALSLPQAAKFQEKLIAEVKSLNASELDSRGVPTVAATDKLPYLDAVIKETLRLYSPLPPSEPRSLPVDTTIDGYKVPANTIVSMSPYSLHRNGDVFKDPLVFNPDRWFGDAKELAEMKKWFWAFSSGGRMCIGLHLAMAEMTSLTAAIYRTYRTGIQAGFEDTTPGITSRFEVFSDETMPKMKEHICLIDFKKHNPQAFLSKWFNGAPISEIKRNNVQQFYRWAFMNSRAGQEGDEEELDEAMQYFQEQTGWKLEPGLGSAKCLRLTLDPVYMLHRPLLVYISMFFVDMETHLFLVSKGYQFYRSSRASFLKVFPLRPQVFLAKSKSPSATLTYWYRPQTSKNKRPIVFFHGIGVGVGPYFKLLSQLTDANARQGEPDEGTPAIIAVEILPISSRMTTHTLSAEAFCLEMEKILNFHGFEDFTLASHSYGAVLTSHLLKHDQISSRIASLVLMDPITLMLACPDVAYNFTRRVPSMANEIELHYFASQEMGVAHTLARHFFWYQNLVWKEDLLYRPSSNPDEPNSYTIRNVTVILSGQDLIVPAQTVAAYLTCPEFPNWDKSPGCTWYQNTMRRPEQRSSWNSEDGKLRLVWFGDLDHAQMLFVKTAADQVTQEVLGRASIKSGDFVGGHIDFDPNDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R2U7</accession>
    <name>A0A3D8R2U7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BP5796_08898</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R2U7"/>
    <dbReference type="OrthoDB" id="1689029at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07000">
        <property type="entry name" value="cupin_HGO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000034">
        <property type="entry name" value="Homogentisate 1,2-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046451">
        <property type="entry name" value="HgmA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046452">
        <property type="entry name" value="HgmA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF5">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20510">
        <property type="entry name" value="HgmA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="14">
        <location>
            <begin position="36"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase C-terminal" evidence="13">
        <location>
            <begin position="313"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="324"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="367"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDW68241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="510" mass="57368" checksum="DC0920FD25E61090" modified="2019-01-16" version="1">MVSIRERKPVEDIQKVLHYTDLQSKSPTRANDPYDYQPGWGNRHQSELIPGTLPVAQNNPQETRFKLYTEGITYSAFAAPRNANFSTYMYRARPAAAHMGFNPIQSTADIENCFLSNNAAVEMLPEQAEWAPFPIPSMPTDFVDGLHTLGGSGDPNLRQGMAQYVYMFTKSMEQRAFCNADGDFLFCPQLGTLDVQSEMGMLYVQPGEILVVPRGVRVSIRLGEGSTAARGYVTEIWGSHFELPDLGPIGGHGLANPRDFLYPIAHIDEDLHVPFEIVYKMNGKYCAIEQDHSPFDVLAWHGNVLPYKYDLTKFSSQNSTSIDHTDPSINTVLTAKSHDPNTPLLDFVWLGPRWDVATNSFRPPYFHRNSASEFLACLYGNMSARSDDFQPGGASSDSGHTPHGGFGDEYVYEMQLQENQPRRILENQMTIMVESSRTLLWTEYARKGCGCIHLKGTNPKVWDKLRDNFSADPLAKKLLAIVKEDRKNAKLKREMLLDDSKLQALLTTHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R3C5</accession>
    <name>A0A3D8R3C5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09068</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R3C5"/>
    <dbReference type="OrthoDB" id="4226666at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF5">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW68411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="768" mass="86313" checksum="524D0048E56345C1" modified="2019-01-16" version="1">MAAHQGLRRMMALHPESTQQVHRPALPPSPDILMLESSEAEYWLSVSSEYSPSGTSYLDANMEKDGSYVFVSGNARKTRASSDETVDVAGESISTLSNDDVEMEFSGDKKERVEERETTMCQKEVLAELYTAQPQPVHNVYDQADTVSTVSYNTEYSQEGMNYCTLDSQFQPDPFSITATPITYSLPSRPMTMTQVATLEDSPWIPLVEEYRTQYPAGYVAFLPKLVPAGLQPTQTVLQGQPTSESSIPIRREKKKPSSSHALPKTKSKGEEVTQALVSWEHIVIQRNGLHKLGGSDNAAASRQRRHGHRKGKLTREAANKAKIIRGMKSCWRCWNLKIPVRYASSRHAKITDSMQCSEDEVCKACIKHCSAPSPANDQLCCRTGFDEYESAFFPEYLSAHLKKKSIEDLISEHTSGFYDNGIDVDVTTGASFKPMRLSTNFFRAESQELLLHHYLGTNLENKDLLVQQCSAPVGLLGVDVGELKKKCQQYIEDMIGNPLYAEQSCADNSTEVPRRVLEVIQRYISVKDQPLIRKAMMLHAINYSMSRLVTFSEDSAARLAEQLGDFPVPYISSRLLNRQIKYAMHKLHRELTREVLKGLEKSMRAKSRDSWGPSFCTILILSLCIEDLQTAADTFVVCDLVKDGIQANLNRGDSFTACSALEEYPYQRCTRLFHDIYHSHRQAGGRVKDGAFNPIKNRCEIDAHSGWDKHTAGMTLVFQDLVSEFDAEMKSLSERPLFLPLDTVVLPAMIRKNNTGRLVSQFLLSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R3D4</accession>
    <name>A0A3D8R3D4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small ribosomal subunit protein mS29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_09216</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mS29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R3D4"/>
    <dbReference type="OrthoDB" id="274828at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019368">
        <property type="entry name" value="Ribosomal_mS29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810">
        <property type="entry name" value="MITOCHONDRIAL 28S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12810:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10236">
        <property type="entry name" value="DAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW68559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="464" mass="50714" checksum="9AA8D4D8DA98FD68" modified="2019-01-16" version="1">MASSGCWKCLLRPSVPVSRPIIANASASFSTTTTLNANPPKKKTGAVKIVKPHQRAGSSLKIKKKAFVKPAGRPPMPGERKALRKRIVLSNTNALEVPMTDLSKDNLLDETLVGKVAGLPDVVVDQLRAVEAFKITQGWGLFRRPAILVREDSVKLARMLEAATEKKEACRVLLDGQRGAGKSMLAVHAMASAFLKGWVVINIPEAQELTTATTDYSPVPNTTPQLYSQDTYVANLLSQIGKANNAVLSTLTLSMEHKDAPIPLQSNISLARLVELGARDPDIAWPLFNIFWREITAAGRPPVMMAMDGLSYFMQYSEYRNPDFDLIHAHDLALVKHLMDHLSGSTKLPNGGAILGVMSRSHAPKSLAADLAITQTEERQLGRPRTKADPFTKYDERSLKVLGNVPVLRLQGLSRAEARGLMEYWASSGVMRTVVDEKTVAEKWTLAGNGIVGEIERGALKMRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7A4</accession>
    <name>A0A3D8R7A4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">UPF0075-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_08332</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW69935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7A4"/>
    <dbReference type="OrthoDB" id="5427593at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016773">
        <property type="term" value="F:phosphotransferase activity, alcohol group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006040">
        <property type="term" value="P:amino sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009254">
        <property type="term" value="P:peptidoglycan turnover"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005338">
        <property type="entry name" value="Anhydro_N_Ac-Mur_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30605">
        <property type="entry name" value="ANHYDRO-N-ACETYLMURAMIC ACID KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30605:SF0">
        <property type="entry name" value="ANHYDRO-N-ACETYLMURAMIC ACID KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03702">
        <property type="entry name" value="AnmK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW69935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="479" mass="51416" checksum="AA6220DAC69ACB4E" modified="2019-01-16" version="1">MVIKGLIPAPKGRVRTAVGHKYLDALQAHLNGDSDRSSSSSPPAGSKSPGLNLLILGITSGTAMDDIDFALCRYTQESPEAPLHLDLIQYDSVVMPSKIRTEILSMLREDAAPPSMLSQMDAEMGHTFANAIHIFAHKHGIAVDDIDLIGSGGQLITLTGKPVKGQHRSNMCLGEGAVISAKTGVTTVSDYRTAEQAVGRQGAPLFAYLVGLLLHHPTRLQICITIGGITTVCFIPSDKKGGIDAMYDWDTGPGTTLIDAAFRQFGLDPAADQARSLLHGQVCHEIIEELLANDEYLAKRPPKTTAREIYGDALASRIISMCLYRGCTPADTIATLTRFTSASIAQQILLYGPGREAINNADIIVDGRGMSNTQLIADLQAEFPGAQFGSFDRTGIPSNAKKAVGFAMQAMEALLGRALPVPTNADVRRPNTITGKLAPGLRWREVIEKSVLFSDAGRGWEGLPEVRELIVKQKEKLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7M8</accession>
    <name>A0A3D8R7M8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein arginine methyltransferase NDUFAF7</fullName>
            <ecNumber evidence="7">2.1.1.320</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_08424</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48108"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:88221"/>
            <dbReference type="EC" id="2.1.1.320"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the NDUFAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.320" evidence="7"/>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7M8"/>
    <dbReference type="OrthoDB" id="5595109at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035243">
        <property type="term" value="F:protein-arginine omega-N symmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032981">
        <property type="term" value="P:mitochondrial respiratory chain complex I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003788">
        <property type="entry name" value="NDUFAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12049:SF7">
        <property type="entry name" value="PROTEIN ARGININE METHYLTRANSFERASE NDUFAF7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02636">
        <property type="entry name" value="Methyltransf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW70027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="515" mass="55923" checksum="7264911B58748913" modified="2019-01-16" version="1">MRSLISSTVRNSLRSAARPRFVPPCRAARWSSTETRQWSTPLAKQLSEAITATGPVPLASFMRMCLTSDLGGYYMSSQEGRDQFGQKGDFITSPEISQIFGELIGIWFVAEWMAQGKKSKGVELVEIGPGRGTLMDDMLRTIRNFKPMASSIEAVYLVEASPSLREAQKKLLCGDAPMTETSIGFQSTSKYANLPIIWTENIRFVPSGNVAQFYEGLTLTLSGPEKTPFMVAHEFFDALPIHAFQSIAPAESGPETIKTPTGEHQLAPEVAKSRQAKEPQWREMVVSPTPPDATHTTLQTPKSQQAANEVPEFQLTLSRASTPHSLYLPEVSPRYQALKGQPGSLIEISPESHTYAEELARRIGGSSQQPKPSPSGAAIILDYGPADTIPINSLRGIREHKRVSPLSSPGLVDLSADVDFIALAEAALKASPGVEVHGPVEQGTFLLGMGIKERAEMLIKALGSDEEKKKRVESSWKRLVDRSGSGMGKVYKAMAIVPECGGQRRPVGFGGDVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7Q3</accession>
    <name>A0A3D8R7Q3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Kinase-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_08479</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7Q3"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14212">
        <property type="entry name" value="PKc_YAK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000087">
        <property type="entry name" value="Dual specificity tyrosine-phosphorylation-regulated kinase 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000380">
        <property type="entry name" value="Serine/threonine-protein kinase ppk15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF17">
        <property type="entry name" value="HOMEODOMAIN INTERACTING PROTEIN KINASE, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="327"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="670"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="728"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="774"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="831"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="163"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="210"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="675"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="731"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="774"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="875"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW70082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="899" mass="99740" checksum="C955D3499E5843D5" modified="2019-01-16" version="1">MDQWQSYSDSAGPSRRYTGNPPPTQPPMTRDYNGSNQAQAPAGFSYEQYQGGLTAHSQSMGSSPVGTPQIRDGNGDVSMQDAGDPYSGRQYPLRPHHSQHLSGGRVAGHHTSQEPSTAAQRYSPMEALSPASPYGAAPPPGPGQYGAQRQSPNSRAGSYSSPNTYYTNRQQNQQIPPISPFTSQSEGYPSSATAQLNAVFGNDPKSPRRPGQPQPAGPPGRGPVPEFTKIRSMADIKPKVNSQPAFRRANPEGGFISPLQALTSHLPSTYRICNPSFKYESSRNPRRVLTKPSKGVKNDGFDNEDSDYILYVNDILGSEETGHKNRYLILDVLGQGTFGQVVKCQNLKTQEVVAVKVVKNRTAYFNQSMMEVSVLDLLNTKLDKNDDHHLLRLKDTFIHRQHLCLVFELLSVNLYELIKQNQFRGLSTTLVRVFAQQLLNGLSLLNKARLIHCDLKPENILLKNLESPIIKIIDFGSACDERQTVYTYIQSRFYRSPEVLLGLPYSSAIDMWSLGCIVVELFLGLPLFPGSSEYNQVSRIVEMLGNPPNWMLEMGKQSGEFFEKRHDVDDYGRRTYHLKSMEQYSREHGTKEQPSKKYFQATTLPEIIRSYSMPRKNMKQSEIDREMNNRVAFIDFVRGLLNINPLERWSPQQAKLHPFITQQKYTGPFVPPMNLKSSSINRSPAPGTQQQQQAEALSKQRAQAAQAQAHSAAAAAAYGAQVPLSPYQQAQPQQTPMYNNNNMYTPNANHQAAPPPYPSQQAAAYGQMGMMPQAQAQMPPAPYGGPSQQQQQSLYTQATMRAGRQRASTMEIQQGGIPPAIQRVASHLDPSQPIRLQPSPAYHPPPPDGAPDGNPGSARRRGSRAAQGGQGGARGNRDFIRNLEDRTLEEGFMGQSQWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8J0</accession>
    <name>A0A3D8R8J0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Putative BCS1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BP5796_08762</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AAA ATPase family. BCS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8J0"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19510">
        <property type="entry name" value="RecA-like_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000768">
        <property type="entry name" value="Probable mitochondrial chaperone bcs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057495">
        <property type="entry name" value="AAA_lid_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014851">
        <property type="entry name" value="BCS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050747">
        <property type="entry name" value="Mitochondrial_chaperone_BCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23070">
        <property type="entry name" value="BCS1 AAA-TYPE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25426">
        <property type="entry name" value="AAA_lid_BCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08740">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01024">
        <property type="entry name" value="BCS1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="BCS1 N-terminal" evidence="14">
        <location>
            <begin position="50"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="258"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDW70365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="484" mass="52901" checksum="2AF591AE5C5E4BB6" modified="2019-01-16" version="1">MSQGSAGPHPSDLKKLTPSPNMSTPGRPPSILNLDVLFDNPVFAGGIGLAGLGAAAAIARRSVIQGASLVKRRLLVDLEISKQDDSYQWILAWLSLPRPSGGVIASSLTRIHHLSMKTTSRAAPNGPSHAHFFLQPGYGRHIVRHGNAFIQVNREKQSSANMSTGEPHETVTLTTLYAHRHVFEDIFAEAHQLAASAQEGKTIMYSSRGMDWVPFGDARRKRPLTSVILDEGIKERIVEDVKDFIGRQQWYVDRGIPYRRGYLLYGPPGSGKSSFIQALAGELDFGVSIINLSERGITDDKLAHLLRKLPPRTILLLEDADAAFRNRQQVDADGYSGGTVTFSGLLNALDGVAAGEERIAFLTTNHIERLDEALIRPGRVDMTVRIGEATRYQAAQMWDRFYGDIDVDGVGRERFLQKLEVLGLVGSASGERSGTFRTSTAAIQGLFLFNKGDMDGAVEMAEGLIPRKYEPEPSAADVGQRVFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCH8</accession>
    <name>A0A3D8RCH8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_07714</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RCH8"/>
    <dbReference type="OrthoDB" id="536881at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017723586" evidence="2">
        <location>
            <begin position="19"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="229"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW71680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="361" mass="36553" checksum="D7109FFCC3279F1B" modified="2019-01-16" version="1">MSRVSLLLLATAARAIYAQNCDAYSNLVKTQSDIDALAGCSAVSGYIGIELAFQGKFYLAGVASIGSINAGNAGASHSTPTQGTPRITSFSMPDLETAKSITFSGVPYLDAFSMPKLKSTDFMELGNMGAVTALSFPALEKLGGNTILSGPLDTIDFSSLTSATSIWIESTGNLDCAALGAQLASISWPSGDGYGLDCVSALNAYHSANTAFAQLFPQSAGVVHATSSAAATSQSSTQQATTTEIPSPTSSPIPAATETTTSISTTASQESASTTTTTSTTASPGSTTTTVLTSTHNTTATSIPSTTEATTSSRVSSLTSSSRASSTSSVPTLVSSGAWRSKVSPWQAMIGLSASAILGLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCY2</accession>
    <name>A0A3D8RCY2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BP5796_07864</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RCY2"/>
    <dbReference type="OrthoDB" id="1689029at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07000">
        <property type="entry name" value="cupin_HGO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000053">
        <property type="entry name" value="Homogentisate 1,2-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046451">
        <property type="entry name" value="HgmA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046452">
        <property type="entry name" value="HgmA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01015">
        <property type="entry name" value="hmgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF0">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20510">
        <property type="entry name" value="HgmA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="15">
        <location>
            <begin position="13"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase C-terminal" evidence="14">
        <location>
            <begin position="287"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="455"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="479"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDW71830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="488" mass="53633" checksum="E909710104E6EEC6" modified="2019-01-16" version="1">MPVTKFSTPEKYKYQNGFGSYHETEAILGALPIGSNSPQKPAYGLYTEKLSGTAFTSPRHENQQSWLYRILPAASHTPFVAREATTYNTNPEGEKLHQIPNQLRWDPFDLDLESDWVHSLQLVAGAGDPTMKSGLGILIFAAGKSMKPEEAFYSADGDMLIVLQHGVLDIQTELGWILVRPNEICVIPRGVRYRVELPEGPVRGYILELYEGHFKLPELGPIGSNCLANARDFQAPVAAFDESPEGEVYTILSKFNGHLFTATQTHTPFDIVAWHGLYYPYKYDLGRFNTIGSISFDHPDPSIFTVLSAPSPTVGTAIADFVIFPPRWLVGEDTFRPPWYHRNTMSEFMGLIHGDYDAKTGGGFKPAGASLHNIMSAHGPDAGTHAKASGAALQPVKVGEGSMAFMFESCLMVGVTEWGLKRCQKVQEDYNAESWVPLPKHFVMREGMQKVSNRVDGDATRGAGDIGASVNGKGATAEMDGKSLPHYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCZ7</accession>
    <name>A0A3D8RCZ7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">p-loop containing nucleoside triphosphate hydrolase-28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_07939</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RCZ7"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000104">
        <property type="entry name" value="ATP-binding cassette sub-family F member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000882">
        <property type="entry name" value="Translation initiation regulator (Gcn20)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF117">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="200"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="5">
        <location>
            <begin position="532"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="300"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW71905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="745" mass="81875" checksum="A576F79720093CAA" modified="2019-01-16" version="1">MEAEIKSFLPNIDPVISEYSVGYLTHASNAYAPDSESTGQSPLAEAATSITALLVSASGDPSPENEAKISQLVGKWVDKFNASPNGEHKQASSAARRLDQAIQVGAQRNMSSTLGLSTGGVDLESANVRKLESKVDRKKLEKAERKIAAKQSKKTFKAVEYEASRLLNQTDDAQSYEEFFMAVNPLQLGSSQGQQKSKDIKLDGVDVSIGGLRILADTSLTLAYGRRYGLVGQNGIGKSTLLRALARRELAIPTHISILHVEQELTGDDTPAIQAVLDADVWRKHLLAEQEKISKQLATIEATRSSMADTSADAEQLDREREALDQTLGDVQSKLAEMESDKAESRAATILAGLGFSPERQQFATKTFSGGWRMRLALARALFCEPDLLLLDEPSNMLDVPSITFLSNYLQGYPSTVLVVSHDRAFLNEVATDIIHQHSERLDYYKGANFESFYATKEERRKTAKREYENQMVQRAHLQAFIDKFRYNAAKSSEAQSRIKKLEKMPVLDAPESEYTVHFKFPEVEKLSPPIVQMTDVSFGYTKDKPLLKNVDLDVQLDSRIGIVGPNGAGKTTVLKLLIGKLTPTSGLISQNPRLRIGFFAQHHVDALDLTTSAVGFMAKNFPGKQDEEYRRHLGAFGITGMTGLQKMEFLSGGQKSRVAFACLSLQNPHILVLDEPMDALSHALQVFQGGVLMVSHDVTMLQTVCKSLWVCDNGTVEKFPGDVQAYKKRITEQADAAGVAAAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RD47</accession>
    <name>A0A3D8RD47_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Berberine protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_07882</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RD47"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017597848" evidence="3">
        <location>
            <begin position="21"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="129"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW71848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="591" mass="64385" checksum="3AD069F64DCF2359" modified="2019-01-16" version="1">MPSKILPVLAIWLLFRSARSQSTGATDPGYNCTSTQSCWPTTSEWQALNTSVDGNLFATVPWAAPCYFSSGHYDSSQCSVIADNYANTTARSSVYGACETLNWETCSGTGCALESLDPSLPPLFQTCSLGSLATYYVAVQNAEHVAATINFTREYNVRLTIKNTGHDYLGRSTAPNSLAVWTYNLQDMIYHETFTASNCPSANGKNIGEIGAGVQAAAAYTFFETYNMNVVGGNEGTVGLAGGYGQGGGHGIFGPSYGLMVDNAVEFDVVTADGKLRTINECNDPDLFWAIRGGGGGTYAVLTAYRFQLYPAIPINVFAFRASFSLLDSSSTLTTIMTAHASNQTNWSNNNVSGHAYYFPDQVEMYLVLPYNDDGSRLKSLTSDFQTFLTNYTNLDITQNNYTTYPKYSEFLALTQSIADRLTPSGDFEVIASRLMPRDLFATPSNVSALVDAVITGMETNENVLDYFSTVPTQVIMTTPANHPDTQNATGLNPAWRTALWHLVYSSGWVKGISDIISDPITTTALAALDPVKALTVGGGAYVNEAHFQEPEWEETFFGSKYDTLLEIKNQYDPTHLFDCFKCVGWRGANE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RD48</accession>
    <name>A0A3D8RD48_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Nitrogen permease regulator 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4 5">Required for meiotic nuclear division protein 11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_08017</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 5">Mediates inactivation of the TORC1 complex in response to amino acid starvation. Required for meiotic nuclear division.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Vacuole membrane</location>
            <topology evidence="5">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the NPR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RD48"/>
    <dbReference type="OrthoDB" id="18648at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0038202">
        <property type="term" value="P:TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056603">
        <property type="entry name" value="HTH_NPRL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005365">
        <property type="entry name" value="Npr3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153">
        <property type="entry name" value="CGTHBA PROTEIN -14 GENE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13153:SF5">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24064">
        <property type="entry name" value="HTH_NPRL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03666">
        <property type="entry name" value="NPR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GATOR1 complex protein NPRL3 C-terminal HTH" evidence="7">
        <location>
            <begin position="777"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="113"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="254"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="650"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="11"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="54"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="149"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="264"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="659"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00030028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW71983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="835" mass="93382" checksum="8EB5D07AF7CDF8D8" modified="2019-01-16" version="1">MVNRDPSLAVSASGRLGPPPLGGTSSTPAAHQQDGPRRLLPTSKLKLWTESRSHPSPNASSSAHPPAKTRSALQMSEHPILSVDTGLVGVCLVIRSRDGPRFVFHHPPRPIIDTVHHQHTQGTEIDQNEVEDGGDGGGDDSGNGNGERADEDTSDSELGDDAGYQKHGKTVARLDNPKASKRRSDHVGPLDSDDHYDGLEGEQVVPWETVFDLPTKDLESILTPQRSFHKKRFELHLDPLYFVSYPVHLREDGTWKKQRKSKKDKQAKNQPLEDNRDEDDIDPLDPGPQQDLEKSVLLKPLSDDDDDHGGMTMFNAVFVLSIPEDGTDEHTFQRIHEVYDNVVKDFNKALKHAQAQCDYVWKESELIMSMKEKAREERRPMSWLWNEIMARSSLAAAIRDVSDAIMRSKIATVHLATNPPVDMSLQIPVPFYLSQLPSIIQSGQRNKGMPGLLVTTANPLLDDDGNIDHAHLNKHFALLLLDDKDKIISELQSDNTELSAPLIEYIKLSPPTQSFLQVAQANSISLNDVKTLAQHLIYWRRAIPIPPLHARDTFIVSPNCDSRKLPNASLAWNKAFPLAPQLPTFLATLSAAPRHYKSFFPSKDHRGQYMDMLAWLIRGGWVTQLRTFCWIMVWPEIIYEVEYERMSNQVNASKEPPESSNSGSNGGNNNSSRRPYIASTSSSTDESGSEKDSKPPLASSNLPLTSEQIAESARLERIALKAEAENLAFAQAFAARPKPEATAHPSLNNAAHLANIAPHIIKDPHRIDEKDSLYMDAIGARIEDEKARKNWARFCRYFNGEDALESIALLEGMKRKEAWGIIAYYQEHLLISRHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDK9</accession>
    <name>A0A3D8RDK9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-terminal of MaoC-like dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_08181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDK9"/>
    <dbReference type="OrthoDB" id="3257538at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052741">
        <property type="entry name" value="Mitochondrial_HTD2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152">
        <property type="entry name" value="HYDROXYACYL-THIOESTER DEHYDRATASE TYPE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28152:SF2">
        <property type="entry name" value="N-TERMINAL OF MAOC-LIKE DEHYDRATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW72147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="36171" checksum="2B19BE9F0E038613" modified="2019-01-16" version="1">MSRILRRLYSTSSPPSSITAADAAAQFLLRYASTPPLIRKQYLDANQLQLLQHTLPPCSANPVQEISPGSPIPAGHHLVYFTPSQPLSELGEDGTDTSYNPAPPFTRRMWAGGELEWVQGATMKAGEEAWEETEVKSAAAKRTRAGEDMVVVGVEKRFGNAGGLSLVDRRNWIFRPSLSSPVSVPRSNTIHAPPPTVPLPSSPNTLDLIQTPESLFRFSALTFNGHKIHYNREWCREVEGHRDLVVHGPLNLICLIDFWRTAVHRKGEAVEVLYPKRVQYRNTSPVYANEMYRVLLENEREKVIEARIVDSFGKTAMIGTIEGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDP4</accession>
    <name>A0A3D8RDP4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Carbon-nitrogen hydrolase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_08045</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDP4"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF27">
        <property type="entry name" value="DEAMINATED GLUTATHIONE AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW72011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="265" mass="28814" checksum="80F5EF89AF441C40" modified="2019-01-16" version="1">MTLAAVGQLCSTKSMGHNLALCKILVKKAVDAGAKALFLPEATDYIASNPQESIALAQPMESSPFVLGLKEAARDSSLAINVGIHVPAKSGKIYNRSCWIDQTGTIKPGYIYDKVHVFDYGALKESNSVEPGSSIAEPVETIVGRVGLLICFDLRFPEISLALKRQNAQVITYPSAFTVPTGKAHWETLLRARAIETQAYVIAAAQVGAHNEKRTSYGHSMVVDPWGKVLVDLPGEGSDPEIALVDIDLDYHEKIKREMPLLRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDV0</accession>
    <name>A0A3D8RDV0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDV0"/>
    <dbReference type="OrthoDB" id="10670092at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW72044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="623" mass="58714" checksum="C6C8A7482A9F8E9E" modified="2019-01-16" version="1">MAGVVWLASRDARTQQHRGRLFSAPARLPDPSARQSVLQRSLIRVRLMIVFRGSHPIPQRSSPIVGKNVTGQLQVKVSWMVMPRSLVDLGKKAAIFDYGVPGSRFPDSVCRVPYASGSIRLNPLTGPSQMKNLGSVLALLALSASTVTAHAIPRNVATTEVQARSYFPGLEMIYTRSPKKGKKANGTATATAATAGKKAKGSKNATATANTATAGKKAKGSKNATATANTATAGKKAKGSKNATATANTATAGKKAKGAKNSTSAATAATSATASTAGAADAAGAAGAADAADAAEAAGGAAEAAGGAEDKKRSMPVWLVDRDVATGTEAEKRDELHNNFLRDMPLLVERKKKNGTATAVAGSAKASGKAAKGAKAAKATKAAKAAKASATAAAASAAGAADAAGAADAADAADPADPADAADAAGAATGATAATGATGATGAAAKAAKASATAAATAATAATADAAGAAGAADAAEPADAAEAADPADAADAAGAATGATAATAATGATGAAAKAAKAAKASATAAATTAATAATADTAGAADAAGAADAADAAEAADPADAADAAGAATGATAATAATGATGATAKAAKAAKAAKAAKAAKAPATAAAATADAAGAADATD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDW4</accession>
    <name>A0A3D8RDW4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08115</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDW4"/>
    <dbReference type="OrthoDB" id="5294241at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW72081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="157" mass="17432" checksum="82C608DBC2E457A8" modified="2019-01-16" version="1">MYSNSTMYGKMSYSYSPSPPSTSYSSTPAMEIRSTSSSARSISPSTSCAYPSWPRRASLSNNNSFETANSYISDDELFPLVFDDADTESNASPMTSPTHSVASGADQLQSTLWMKEFMAEEKARKHREREASKRRSRSSSSRKSRSSSTQKMTPILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RE52</accession>
    <name>A0A3D8RE52_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_08232</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RE52"/>
    <dbReference type="OrthoDB" id="4078873at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000284">
        <property type="entry name" value="Siderophore iron transporter mirB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF107">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="308"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="350"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="556"/>
            <end position="574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW72198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="590" mass="65248" checksum="584B8FA3C1FDADD8" modified="2019-01-16" version="1">MKNIFGSPTTETQLGVETAVPRDANPEITELKNDVESTAVKAADEAPDSRDQLGVQKAEAVTILWTKKQLLVAYGFAFLVFFVVSMEQQIQNNLSYYVYSSFSLSPAYGVGTIVGSITTGVFRLPLAKIIDLTGRAEGLALMTCIATIGLIMMASCKTATVYAAAYSFYWVGFDGITYVLTIFIADTSSLKNRAWMEAWTTTPYIVTTFIGSRAAASFLETSGWRWGYGSFCIITPVIAAPIVFIILRNQRFAMKSGMIHKPESGRSVSENIAFYFWEFDVIGLLLITAGISLILLPFSLASYQTKGWGSGMIIAMLVIGFLCLCAFPIWEKYVSKRCFIPFYLLKDRTILGACFLAMLIDISFYMWDTYFYYFLQVVYGLSVVNTGYMTNIFSIGSCFWAIPVGFAIRKSGYFKWIAFFSLGLEMLGAGLMIYFRSHDQGIGYQVMCQIFIAFGGGALVVCNQLAVMASVSHANVAGIVAFLQLFASVGSSIGLAVSEVIYQNTFYDALLGALPSHNETLAAELYASTTTQLLYPMGSDERTATIYAYEYTQKKLCIAALCWLIPGMFLISMWKNFRVSEMRQVKGLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RI69</accession>
    <name>A0A3D8RI69_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Oxidation resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_07184</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">May be involved in protection from oxidative damage.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RI69"/>
    <dbReference type="OrthoDB" id="26679at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF62">
        <property type="entry name" value="MUSTARD, ISOFORM V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="7">
        <location>
            <begin position="102"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="39"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="202"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="219"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW73742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="344" mass="37274" checksum="85BF2CB0493E7E6B" modified="2019-01-16" version="1">MPQPGGHENNPTSSASEPSPPLSSSFYIPSAISHSVTGLLRRFSTDPSQPSSSKATQSPVHSPTFPNDAVYVPRRTASPFQPPPLYPITLKGYQSDTAESAHLLSKTLAEEIRLLVPPRLQLCEEWNLLYSLDQDGVSLATLYKKCDELRGLRNGFVLVVKDGDGGLFGAYLTEAPHPSPHYFGTGECFLWRAAILRPSAMMQNLPPPPSADTTQAQRTTTLGTTSSPSPLSPTTNMHPNPYAPSVPSLLSPQTPTFPSGASTPERIRFKAFPYSGVNDYLMLCETGFLSIGGGDGKYGLWLDDSFEKGISSHCLTFGNEPLSEEGDKFDIIGVELWSIGNLRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RI98</accession>
    <name>A0A3D8RI98_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_07214</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RI98"/>
    <dbReference type="OrthoDB" id="9975579at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.580">
        <property type="entry name" value="Acetamidase/Formamidase-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004304">
        <property type="entry name" value="FmdA_AmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054833">
        <property type="entry name" value="FormamaseFmdA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF045496">
        <property type="entry name" value="FormamaseFmdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891">
        <property type="entry name" value="FORMAMIDASE C869.04-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891:SF1">
        <property type="entry name" value="FORMAMIDASE C869.04-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03069">
        <property type="entry name" value="FmdA_AmdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141130">
        <property type="entry name" value="Acetamidase/Formamidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW73772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="440" mass="47886" checksum="F54AEF746EF2CC93" modified="2019-01-16" version="1">MGKVGIRNICPVRLDIPAAEQPMLHNRWHPDIPFVPGAIKNGETVKIECVDWTGGQIGNNDSADDVKNVDLTKIHYLSGPFEIEDAEPGDVLLVEIMDVQPHQDHPWGFTGWFTHFHDGSGRQLTELISAKAIWDFEGIYCSSRHIPHVKFPGLIHPGILGCAPSHEVLATWNKREGELISANKLDRIVAQPPNATNVHAGSADDDVKSKVGAEGARTIPGRPEHGGNCDIKNLSRGSKVYLPVHVKGAKFSVGDLHFSQGDGEISFCGAIEMSGVITINFKVMKNGIADLGMKSPLYLPGPVEPHYGPGRYLTFEGFSVDQHGKQHYMDVTVAYRQTILRCIEYLRRFGYSDYQIYLLLSCAPVQGHVAGIVDIPNACTTLGLPMDIFDFDISPSGPAKKLDMGSCAFETGVSEGKVTNGGENSEISWGGGLTFTEKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIY5</accession>
    <name>A0A3D8RIY5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">methylmalonate-semialdehyde dehydrogenase (CoA acylating)</fullName>
            <ecNumber evidence="2">1.2.1.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_07451</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.27" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIY5"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004491">
        <property type="term" value="F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006574">
        <property type="term" value="P:L-valine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006210">
        <property type="term" value="P:thymine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07085">
        <property type="entry name" value="ALDH_F6_MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000002">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase (Acylating)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000003">
        <property type="entry name" value="Methylmalonate-semialdehyde dehydrogenase [acylating]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010061">
        <property type="entry name" value="MeMal-semiAld_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01722">
        <property type="entry name" value="MMSDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866">
        <property type="entry name" value="MALONATE-SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43866:SF3">
        <property type="entry name" value="METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="79"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW74009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="566" mass="60678" checksum="AE6C2945A0105045" modified="2019-01-16" version="1">MRRVLARGISAAAVRVPRSAPSPHIASSSSRIATRQFHISAQQLRPASAALAFDADNYPMNHEKIESPKDTPYFIDNKFVQSEATQFIELHDPSTNNLVTRVPQSTDAELKAAVESAQKAFPAWKATSIMARQQIMFKFTQLIRENWDRLAASITLEQGKTFADAKGDVLRGLQVAEAACAIPQSMVGEVLEVAKDMETRAYREPLGVVAAICPFNFPAMIPLWSIPIATATGNCLILKPSERDPGAAMILAELAQKAGLPDGVLNIVHGAAKTVDFIIDEPAIKAISFVGSNRAGEYIFTRGSANGKRVQANLGAKNHAAILPDANKQHALNSIVGAAFGAAGQRCMALSTLVMVGETKEWLSELAESAKALNVNGGFEKGADLGPVISPQSKERIEKLIDSAEEEGATILLDGRGFKPEKYPNGNWVGPTIITNVKPHMKCYTEEIFGPVLVCLNVDTLDEAVDLINANEYGNGVAIFTKSGATATAFQKNIEAGQVGINVPIPVPLPMFSFTGNKKSIAGGGASYFYGKPGIQFYTQLKTVTSLWRSEDAISKAADVAMPTHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJD6</accession>
    <name>A0A3D8RJD6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">U3 small nucleolar RNA-associated protein 13 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_07605</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the ASTRA complex involved in chromatin remodeling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJD6"/>
    <dbReference type="OrthoDB" id="5414888at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001009">
        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001144">
        <property type="entry name" value="WD40 repeat-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013934">
        <property type="entry name" value="Utp13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF15">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08625">
        <property type="entry name" value="Utp13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="108"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="227"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="422"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="502"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="533"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="607"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="659"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="682"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 13 C-terminal" evidence="8">
        <location>
            <begin position="735"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="176"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00037338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW74163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="905" mass="98863" checksum="69C4B9EF440D7D7E" modified="2019-01-16" version="1">MANKAPYQTTFEPAQSIQPIYTGGSVALDQSGRILATTLGEDALLTDLNTGRQLAKIEGDGEIISTLTLTPSASHLIICSRSLSMRIYTLKPSATTKFAINYELVRTLKPHTTPVVVLAVDQTSTLLATGAADGVVKVWDIAGGFVTHTFRGPNVLISALHFFELVASNRNEETGISARNRKKNGRSSNVDDDAEDDSTRGFRLASGSQDGKVRIYDLHKRTCTSVLDSHVSDVQALDYSSEENALLTGSRDKTIMWWDAKTWKVRKVVPVLEEVEAAGYIGSGRFTYTGGANGNIRIWQTENGREVTQPQAAKSEEAAILAILSQPELPFIVSIQADHTLILYSTSSVAEADSTVTIAKLPQLKRISGTHDEIIDLGYLLPDRSLLALATNSEEIRIVSLAQGDEDSSENTVYFGADVAQLRGHDDIIICLDIDWSGHWIATGAKDNTARLWRIDPANNSFSCHTTFSGHAESIGAISLPHQPPPESSPAFKNPLDHPPEFLLTGSQDQTIKRWDIARGQGARKAPRALYTRKAHEKDINAIDTNHNAQLFASASQDRTVKIWSVEEGETQGVLRGHRRGVWSVKFAPKETPSIIGENGPAAGKGLILTGSGDKTVKIWNLSDYSCLRTFEGHTNSVLKVSWLKLPNAEERGRRHVHIASAGGDGLVKVWDANTGELECTLDNHEDRVWALTVHPETNTIVSGSGDSTVTLWKDTTTSTAAATTAAATQLVEQEQQLQNYIHTGSYRSAITLALQLNHPARLLSLFTTVVTGKNEEGSLCGLVAVDEVLATLSDEQIFTLLLRLRDWNTNARTAPVAQKILWTLVKSYPAARLSNLKVKGGQGQRSLKEVLDALRAYTERHYKRMEDLVDESYLVEYTLREMDGLGELEGVGGTIENGEDTIMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJG3</accession>
    <name>A0A3D8RJG3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_07635</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJG3"/>
    <dbReference type="OrthoDB" id="2520703at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW74193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="428" mass="48153" checksum="26937F342C5BD05F" modified="2019-01-16" version="1">MLNSPTLTALPSETLQLIFGTFCLHCSANHQPTSPDRYLHHTPQHGDEPSWYSLKRHALFSLCLVSKRCRDLAQPILYHEFVLGYGDSWRSTLYTWDGRLAAFVRTIAQRRQLAMLVKAVYIQPSLLHSLRDEKFRDALGQAAHALKIENWQQLSGSTLVPLLIAELPNLEYLSLETLQHDMCDGIAVVPSLSNLRTICIIYSRLGEKNLEALLSACPGLCTFVYEATHTQVEGQCTMLDGRDHFQPSRAVGYLRHHRATLKSLHLDLRWRGWSPLTEGRQVKPVFSFADFTALEHLFINGSEVFSRPWIASPADSQFLVKLLPPSITSLHLAGEVGNARPRLAKGLLGLAEAISQGKFPRFKQIRCDIQQLLDDGYNVAATLAAVEVDFGYDSWPLGKVTFQENDNLSLLEYLEPMPLPDSDYDSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RNU3</accession>
    <name>A0A3D8RNU3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_06540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RNU3"/>
    <dbReference type="OrthoDB" id="3045089at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035329">
        <property type="term" value="P:hippo signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051583">
        <property type="entry name" value="YAP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17616:SF8">
        <property type="entry name" value="TRANSCRIPTIONAL COACTIVATOR YORKIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17616">
        <property type="entry name" value="YES-ASSOCIATED PROTEIN YAP1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="6">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="6">
        <location>
            <begin position="93"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW75719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="136" mass="15005" checksum="CD7B460BC7073082" modified="2019-01-16" version="1">MTINSSPPANYEHPKDTNRASPATLIEVHAVGSREASTSFPGIALPVGWEQSTTPAGRPYFINHNNHTTTWIDPRTSRAVTDNATGSVSLAGSPLPTGWEARRAQNGRTYFIDHVERKTTWDDPRYSSNIEISNEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPD3</accession>
    <name>A0A3D8RPD3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Kinesin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BP5796_06734</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPD3"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000073">
        <property type="term" value="P:initial mitotic spindle pole body separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01364">
        <property type="entry name" value="KISc_BimC_Eg5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000051">
        <property type="entry name" value="Kinesin-like protein bimC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047149">
        <property type="entry name" value="KIF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047241">
        <property type="entry name" value="KIF11-like_kin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025901">
        <property type="entry name" value="Kinesin-assoc_MT-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF12">
        <property type="entry name" value="KINESIN FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13931">
        <property type="entry name" value="Microtub_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10 14" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="17">
        <location>
            <begin position="65"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1138"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="411"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="722"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="50"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <begin position="151"/>
            <end position="158"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDW75913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1165" mass="128620" checksum="C28499E60358B63C" modified="2019-01-16" version="1">MAAPTRKNSMRPPPRPTSVRAQSLQPPSRSGAVSPAESMISVATTAGGTKRKERDFDHDDGMETNINVVVRCRGRNEREVRENSGVVLATDGVKGKSLELSMGPSALSNKTYHFDRVFSSAADQSMIYDDVVTPILDEMLSGYNCTIFAYGQTGTGKTYTMSGDMNDTFGMLSDAAGIIPRVLHSLFTKLELDDAESSVKCSFIELYNEELRDLIAPDDSVKLKIYDDNSKKGHSTTLVQGMEESHIKSAVDGIKLLQSGSHKRQVASTKCNDLSSRSHTVFTVTAYIKRTGDNGEDYVSAGKLNLVDLAGSENIQRSGAENKRAAEAGLINKSLLTLGRVINALVDRGSHIPYRESKLTRLLQDSLGGRTKTCIIATVSPAKSNLEETISTLDYAFRAKNIRNKPQVNQVVNKKTLLKEFTAEIERLKSELIATRHRNGVYLSNESYEEMTVESESRRILSEEQAAKIETMETNLRNKVQELFSLTSNFMTLKKDAENSKVALDETKSVLDQTEFVLANTRQTLAEEALLRKAHQHTEEQLSVVGSELISTLGRTVHDIDGLHAKNRRKSDLSILHRNTWGLSQAQVAEVTNLVESRVEDFKSQQQDLMATVSNRMHAFVDGELEKLSATQTFLEANITAFEGSEQEVSEQTNSAKEKMDAVLEEIKSLRDEVKMRVGEGLQGLSVAAERISAEVISELGAFHSQLHTSYSSLGRDFKGLFEELLKHIDSQKIEANELRQQLNLASELAMQSSAASSNRLEEVLKGEREQAAADRHNLLSQITSLVMAQGEAQDTRMTTKIAAVQSDIMTAKEVFESSRTEYIEGMDSWNEKENRLVEEVARTRETLKSKLKEDWMAANNHNASLQTTTKAVHEETVRIVDNQMKDISFQMQALDDFVTRAQSQNAEHHDSHVRSLGGLSSTVKSSYANIGNHFTTTFERVKSLGEEMSQKTVTLQESLTPLDESLRQPLSELRSNISNTMLQEYVPTGETPQKMQYQYPTVLPRTEAHEKLLSGVRPAQEMVYSPSKSPALPTIFNDVVMSGGEEVALIPSSSEAEVGKPTIGLREIDINTLSSGGLLDCPSENAVNGTVKSNDDDSNSSNMTQLPMFKKSVFSNNSNRIPMPKLTKKPSVVALEGRENVPSAFSQSIGRRRSPRTAGGSGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPM5</accession>
    <name>A0A3D8RPM5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DUF202 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_06776</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPM5"/>
    <dbReference type="OrthoDB" id="199599at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052053">
        <property type="entry name" value="IM_YidH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187:SF2">
        <property type="entry name" value="DUF202 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34187">
        <property type="entry name" value="FGR18P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="DUF202" evidence="7">
        <location>
            <begin position="20"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW75955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="142" mass="15021" checksum="180C3E8D40F52364" modified="2019-01-16" version="1">MRLPSFRFVGPIANTGSVARDHLANERTFLSWTRSGLAFVALGVALAKLGALEALSPALKQNHGDLEWPSMALVGSGGGCLSYGTLRYFSSLRLLQKGLFRPNIAGIALVAVTSAAVAGGGIVLVVQQETKTIREGRLRSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RUV1</accession>
    <name>A0A3D8RUV1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CBM-cenC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_05699</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW77847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2845956at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003305">
        <property type="entry name" value="CenC_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032345">
        <property type="entry name" value="PnbB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02018">
        <property type="entry name" value="CBM_4_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16155">
        <property type="entry name" value="PnbB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM-cenC" evidence="3">
        <location>
            <begin position="793"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="398"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="745"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="405"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="417"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="482"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="513"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="541"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="579"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="745"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW77847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1336" mass="141299" checksum="0FE4F32C9AB19373" modified="2019-01-16" version="1">MPQSHFQGDNTFQVPLYLIDFPKLQRACICIYERRLGKRDALPRSPIQRRDKTTTTTQFRTTVTSSVTTKIITNFVTKSVTVFTTIVSTVPRATTTKLSTLSGSRTTIVSTITSTFVPNTKTVTASARIVTVTQSAIASTITVVSKTTASASTVTRVSTIPGAASTVTVVSRSTAPASTLTRVSTVSRVASTITVVSTAAASLTTVTRLSTLTGAASTITVVSTAFPHTSTVIRVSTMPGTASTVTVVSTASPPVITVTRLSTMPGTASTVTVVSTASSSVTTVTRLSTISGAGSTLTVLSTVSAINGVASTITVISTHSPPTSTVTSFSTIPGAASTVTVISTMSPPISTVTSISTIPGEASTVTLLSTETDSTVISGSISTIYVATTINTCASADASSTTTSEQPNTGTTAENLSTTISDSSTATTEDLSTATENLSTTTSESSTATTEDLSATITQDSSTTAENLSTTTTEDLSTATENPSTTTSDLSTATIEDLSATITQDSSTTAENLSTTTLDSSTTTTEDLSATITQDSSTIAENLNTTTLDSSTATTEDLSTTMTQDSTTTTSSPSCSATPPIQNSDFESGTINPWTVHLGGPARVDYYDDADHAPNAHSGSGYVEFTTDSDEPGVDFGIIQYGAVCPDTDYQVEIYIALSQFSTPGGDPTTTICRINVQIADTGYIFYPTGISGWQRLTATVTPHGPASPDTILRVFTSNNFPLCPYTLIRLDDISITPVNDLASMPTPSISSVPSTSATDPASATTSTSTDSPSITSSNSVAISTSCPTTRPNQIINGDFETGTLDPWDYNSAGYTLQITNQGAHSGTYAVYMQNPANAFNNYFRQGVTLDPPPTGSLVMTAWAQKHASSQCQFHFELYSSSGEVYGSDFPLSTTYQKYSTTYNLPGDNYRLTIAGVHCVAGMTIDDITFTVSPSGQCSTPADCSPSIDGDVLVNGGFECLGFEGLEPFTFTGSQSTTASVLGTYHSGSYGLRIWDWTDNPIVFDLSQTVSVVPSQTYQLTGWASSISASGQSPCTFQVIFDQAGISTNIALTTSGFTSFSVVYTGSPETFETIHIHGDSTCGSDLYLDDLSFVPLGTCSRFHGGQQMISPFEVKVVDIMLLQPEQKSSAIIISTFITKYQHPEFTPHRFSMTERQIPVDHPNHQRLLDSVQRFLAEVQNLIPGKDLERHLNEEYGPGNAYYDTFASIVRQGILNSEGWLANIEVDGPKYHRSKVSLPMPQTQYFSVTTVYMDSVDEYRGQYHQHPYGEINCVILIDPTAELMGMSGWQGAGWTSPGPGTHHYPQVRGGALVALFFLPAGRISYEATANTPQPISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVE2</accession>
    <name>A0A3D8RVE2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_05875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVE2"/>
    <dbReference type="OrthoDB" id="10292198at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="13"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW78023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="134" mass="15418" checksum="54AF4484A66330BC" modified="2019-01-16" version="1">MGHLLSIIDSAEVFQTHSPKSPPTESYPLSSTPPPPQPYSNPAFQHLSKSRSFDPLSIFQDHKTNARVVNILAERYMQKFEYLALNCGDLESVRQKCRQDVGWVRQKFWNEGWGEPGDEVLLWWFGVHEGDKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVQ5</accession>
    <name>A0A3D8RVQ5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">aromatic-amino-acid transaminase</fullName>
            <ecNumber evidence="9">2.6.1.57</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_05927</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>an aromatic L-alpha-amino acid + 2-oxoglutarate = an aromatic oxo-acid + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:17533"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:73309"/>
            <dbReference type="ChEBI" id="CHEBI:84824"/>
            <dbReference type="EC" id="2.6.1.57"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.57" evidence="9"/>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVQ5"/>
    <dbReference type="OrthoDB" id="691673at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047536">
        <property type="term" value="F:2-aminoadipate transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008793">
        <property type="term" value="F:aromatic-amino-acid transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009074">
        <property type="term" value="P:aromatic amino acid family catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006571">
        <property type="term" value="P:tyrosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000074">
        <property type="entry name" value="Aromatic amino acid aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050859">
        <property type="entry name" value="Class-I_PLP-dep_aminotransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42790:SF21">
        <property type="entry name" value="AROMATIC_AMINOADIPATE AMINOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="10">
        <location>
            <begin position="189"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW78075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="535" mass="59344" checksum="F1BCE6930C26A739" modified="2019-01-16" version="1">MAPHYSADLEPAGLSDTQAVVVSKSSITDSITQRRAQAGRLIAGVAFAASSDNFKAPSTGKPKARRWDHYLSLESKSRTPSSLKAAARFLKQPGMISLGGGLPCPEYFPIDEMTIKIPIPPHFSEKETKETGQVVKAGKYEVSEGHGSYDLSIALNYGLGTGSAQVLRFVTEHTEIVCNPPYEDWHCALSVGSTSALEQTFRMLCERGDYILSEEYTFASAVETAAPLGIKFVGVKMDSEGLLPESMDEILSNWDEKVQGARKPHLLYTVPSGQNPTGATQSTARRQAIYKVAQKHDTYIIEDEPYYFLQMQPYTGPGAPDVPPPANNEEFLKVLIPTYLSMDVDGRVMRMDSFSKVIAPGSRVGWITASEQIVERFVRHNECSNQNPSGISQLVLHKILDESWGHDGYLKWLINLRLEYTRRRDVLLGACEKFLPREVISWNPPAAGMFLWFKIDWQKHPDAQSKFILDIEEGIFMAAINAGVLLGRGSWFTAEKGPVPTDMFLRATFAAASNEKMTEAIERLGAALREHFRIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVU7</accession>
    <name>A0A3D8RVU7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Uridylate kinase</fullName>
            <shortName evidence="9">UK</shortName>
            <ecNumber evidence="9">2.7.4.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:UMP phosphotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Deoxycytidylate kinase</fullName>
            <shortName evidence="9">CK</shortName>
            <shortName evidence="9">dCMP kinase</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Uridine monophosphate kinase</fullName>
            <shortName evidence="9">UMP kinase</shortName>
            <shortName evidence="9">UMPK</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_06044</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>UMP + ATP = UDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.14"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="9">Binds 1 Mg(2+) ion per monomer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <text evidence="9">Predominantly cytoplasmic.</text>
    </comment>
    <comment type="domain">
        <text evidence="9">Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.14" evidence="9"/>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVU7"/>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033862">
        <property type="term" value="F:UMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000315">
        <property type="entry name" value="Adenylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03172">
        <property type="entry name" value="Adenylate_kinase_UMP_CMP_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006266">
        <property type="entry name" value="UMP_CMP_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01359">
        <property type="entry name" value="UMP_CMP_kin_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6 9" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9 10" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="9">
        <location>
            <begin position="143"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="9">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="123"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="171"/>
            <end position="173"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="204"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="211"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>a ribonucleoside 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58043"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW78192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="304" mass="33529" checksum="DDC5226A3D1E1BF4" modified="2019-01-16" version="1">MIQPRFLARRLFQQTSPLQSLASHAGRPIRASILRSQARRSYAASGEKGPRPIPGQSPFKIWPFLAIILAGSGSYMLLVKSRTDMAAAVQASKSSGQIAAPKKDTPTFSSDKVTVVFVLGGPGAGKGTQCANLVRDYNFTHLSAGDLLRAEQDRPGSEFGQLIKDYIKDGAIVPMEVTVQLLENAMTETLSKTKDGKGRFLIDGFPRKLDQAVKFEESVCKAKFVLFYDCPEEVMEKRLLKRGETSGRTDDNAESIKKRFKTFVETSMPVVDTYDKEGKVVKVVANKSPEEVYAETKKKIEGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWK8</accession>
    <name>A0A3D8RWK8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_06257</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWK8"/>
    <dbReference type="OrthoDB" id="3561643at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="151"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW78405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="411" mass="47364" checksum="78D92F364DC74621" modified="2019-01-16" version="1">MTSSDISTDGSAATPSSENGSVPTPEMPTKKYDFNLEYQKLQEQIAVFQQVLDPKAELATKTAHYDKAYADLKAIETKYECLLAEYHNIKHSLSGHEADWRGTMAVYRRTVQELAKGMQDANAIEHDLELCEAMREEARNFMVFSHDMIWIMRIKREVEEKGKLLEEIKAEVRLLEDKVAQARLAVDAATVDVNAAVLRWQDAYDKIKLEQEKTTPVLKPATRTYKAEDVQEAFDAGAKKVREDLIPLAQAGWNIRNRHHEWNLDRDIFSHEQDKGIIELGDAASHYGMALADSCLCTLEGYGLGKYRNNPHTFCKLYEKTPQEVLQVKRNSKLLHILDWYGTLKVILRGYYPSERFRNGMRTVWRATYGKTEAEIIKFFEGKEGRALFGMLKDEHDTQLQKHREARGWKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWN5</accession>
    <name>A0A3D8RWN5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vacuolar protein sorting/targeting protein 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Carboxypeptidase Y receptor</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 16">Sortilin VPS10</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BP5796_06344</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Prevacuolar compartment membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="443634at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.270:FF:000005">
        <property type="entry name" value="Sortilin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.80">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.270">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF27">
        <property type="entry name" value="SORTILIN-RELATED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15901">
        <property type="entry name" value="Sortilin_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1357"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1405"/>
            <end position="1428"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="18">
        <location>
            <begin position="50"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="VPS10" evidence="18">
        <location>
            <begin position="715"/>
            <end position="1346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00031250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RDW78492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1475" mass="165742" checksum="A583DFF000793C1D" modified="2019-01-16" version="1">MRLRSFEAVGWQRLLTTTLLYGSAWAKKESPSIKSTTVANPAYNLQYFDDSNVVMFQDELARAVYRSDDAGEEWKKIDKIPEKAAVELMMHPFDNKRAYIITSGSTHWATSNRGESWEEFFTDVQPSYFREALTFHAGDPERIIFNGMDCTGIFCEELTLYTTNGFSKDARFLRGDTAGCHWAKSSESFTTGQKDLDASRILCVVKGRFSPWRKDYRLLVSDNYFTSNGDDIQEFEPELEPGRTVQGIVNMAVVHKYLITAATADGTDEMALYVTDDTVKWHRAEFPHDHKLIEEAYTVLEGTNYSIQIDVMNTRPTNPMGVFLTSNSNGTYFTRNMEHTNRAQSGLVDFEKVSGIQGIVLVNTVENWEEVEKKNVQKKIKTQISFDDGRTWQNLKAGDKDLQLHSVTELSNSGRVFSSPAPGLVMGIGNTGDSLKSYNDGSLFVSDDAGVTWRKALDGPHKYEFGDQGSILVAVKDALTDTISYSLNHGKDWKEVELEHKMRPMVLTTTQDSTSLKFLLTGYDDRKEKTKNYIVAIDFDDMHEDKCSKADMETWHARVDADGNPTCLMGHTQSYQRRKADAKCFIKNEFKDPEVISKSCPCTDADFECDYNFVRSEDRKECVRAGSLVLPEGACKAFGPDDTFKGSSGWRLIPGNDCKRVSGKQRDDPVDTKCVDAIGAPSSGKVSHTQETFSGTHFYNKAYLERTGISAGEDETIIMRTDAGSIFLSHDHGKTWQEILKNEKIMQILPHPYFNDVVYFITSGKTVFYSIDRGDNIRSFEAPYPPNDKRLPVMSFHQKNKDWIIWTGGRDCETADRCHAVASLTRDRGDDWLTLQRYVGRCEFIKEAEQQERSENLIYCEVRERETNDLKDNPLQLVSSDKFFADPPTVHFKNIIDFATMSEFIVVATKDEEHQTLKVDASVDGATFANALFPHGFNVPHQHAYTVLDSSTHSVFLHVTVENEQGFEYGSIIKSNSNGTSYVLSVNAVNRDRQGYVDFEKMAGLEGVAMVNVAANFDTKKKSEGKKLKTMITHNDGAEWDYLSPPAKDSDGKSYCSGSKDQCSLNIHGYTERTDKSNTFSSASAIGLMLGVGNVGQYLTSYGEADTFMTADGGITWKAVKKGTYMWEFGDQGSIIVIVKEKTETKVVYYSLDEGASWLEYQFSDTEVHVDDLTTVPSDNARNFLLWGHVNDKLVTINLDFTGLTDQQCKLDEKDVEGGDYFLWKPKHPKQDDDCLFGHISQYHRKKPTSNCFNGRMIPHLHNIASNCSCTRQDFECDFNYERQIDGSCALVKGLQPSDHSAVCKADENVFEYYDPTGYRRIPLTTCVGGREMDVSVAHPCPGKEDEFQKKRGTSAIAIFFAVIIPIGLAAGAGYWVWTNWNRKFGQIRLGEQASFETEPPYIKYPVIVISAVAAVGAALPLLASSLWRSATNAMGRGSTRRFTTRDSFARGRGDYAVVDEDEGELLGEDSDEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWT8</accession>
    <name>A0A3D8RWT8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_06369</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWT8"/>
    <dbReference type="OrthoDB" id="261831at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.110:FF:000057">
        <property type="entry name" value="SNARE complex subunit (Bet1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW78517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="77" mass="8942" checksum="64A36D96088E0693" modified="2019-01-16" version="1">MGKVRQLKDMTIAIGDEIRESSALAEKMNDSFDNTRLRLRGTMNRMLVMAERTGVGWKVWLAFFAAVGFLFFYVWVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2N2</accession>
    <name>A0A3D8S2N2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_05118</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2N2"/>
    <dbReference type="OrthoDB" id="4160565at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="125"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="89"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW80420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="184" mass="20262" checksum="9F9173B905236313" modified="2019-01-16" version="1">MPSFHTSYLVPAILLNPAFILHLFNTFISHISPPPYTTSVSPHPFMESLGPLPGTKIALDVHANEQLCWSYTAIMVLIQCLAFGRVQGNRVQRRSARAARAEREKLRKEKPSEEEVSGPALKIKMNGHATGLDGAGSDTERELELNAQKTRRPLSEITGQYSGTVPTLESEGSMTETSEEEIMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S341</accession>
    <name>A0A3D8S341_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_05425</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S341"/>
    <dbReference type="OrthoDB" id="413079at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000286">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000308">
        <property type="entry name" value="MFS efflux transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051788">
        <property type="entry name" value="MFS_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514">
        <property type="entry name" value="BYPASS OF STOP CODON PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23514:SF6">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="360"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="415"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="108"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW80727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="505" mass="54005" checksum="4043C6DF8AD5C1DA" modified="2019-01-16" version="1">MSSHAFGAFISVERSTAAGSHELPEAPQKAVPRTYHSVPHTPDIELDNIQWGTKLNGQTKSGTATPSGTQTPRVPNDLEMSRQVTPIVEDEGVDALQSFSNPPINRFRMLTVCLLNFTNGLSDSAPGALIPYIEKYYNIGYAIVALIFVTNAIGFISAAFIVDALRAKVGRARSLMTAQTFMLLGYIAIVCTPPFPVVIVSFFLLGFGMAINLALGNTFAANLQNGTTMLGAMHGSYGLGGTIGPLIATAMASSGGLIWSRYYLLPLSMSAIMIVQAGWSFWNYEKDSDHSLLTNIERTASQAQNGGISNQFADMAKTFRSKTVILGALFIFAYQGAEVSISGWVISFLIATRNGDPSRVGYVTAGFWAGVTLGRFVLSHPAHKIGEKLFVYGMIIGAGVFELLVWFVPNIIGDAVALSIVGLLLGPIYPCATHIFSRLISRKDQVSSMSIISAFGSSGGAVAPFTTGILAQAAGTFVLHPIAIGLFCVMTASWFSLPSIRKRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3H4</accession>
    <name>A0A3D8S3H4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transport protein particle subunit trs85-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_05523</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3H4"/>
    <dbReference type="OrthoDB" id="203724at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024420">
        <property type="entry name" value="TRAPP_III_complex_Trs85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975">
        <property type="entry name" value="TRANSPORT PROTEIN TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12739">
        <property type="entry name" value="TRAPPC-Trs85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="641"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="646"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="697"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW80825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="711" mass="79209" checksum="AE4A446D243B763E" modified="2019-01-16" version="1">MSPSGISTPSRIAGSVFGDTPNEGAMLEPNDQPQDARNLISQAYVPHIAVHTSSDTKELVKDKGFDGGLWELLRPFGERVQGKVTVRDSIGAGKTWDDFAVRFVELGDGLERSEQARKSSEIKSPTMPESAGFTLGQRARTGGDVTQVEALVERHLTYSEEFPSMHTEDYLTYTGTPSDPESASPFYTLYLRRLLSAIPLSPHETFSHPVACIIAISSRNANPIEALRNLYDESSHGEKRLPLWVNNEYLRYYVLVHDEERDDITKSMTLFDQMKRHFGLHCHLLRLRSSQCVATDDDSVQLPRCQWMSATEELADIQARESLEDIEDSFPCVYESDTTAIKTFIREMVTQSVIPSMERCVSTWNDQVASRRRGISGRFMSLSKKWTGFGGSSRSSSPAVGSGSSSGSYSNYDAVQGFYRPDAAEAVMRKLADYAFMLRDFKLAQSTYELLRTDFNNDKAWKYHAAANEMAAISTLLIPKAMSSKTRTETVDQMLETASYSYITRCGAPYGALRSLALGMELLRLRDGSATADAARWGVRLLEYKVVGPIGDALIKERVARCYASKKGAGSGLWGARTRKSTLWSILAAEAWLSLGKYQQARLRLNEADNKSSLLAHRDALETFSEANVFLQALRREVQDPYRDADSDERDTDVDEIETTVEEESETFNGRSHRRSLMGPAIPPLSSIETAPLQTTLMDEAPKSATADQFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3Q0</accession>
    <name>A0A3D8S3Q0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BP5796_05617</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000055">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000066">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002145">
        <property type="entry name" value="ABC transporter (MsbA subfamily)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF399">
        <property type="entry name" value="ABC TRANSPORTER ATNG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="328"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="908"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="950"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1026"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1052"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1140"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="297"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="631"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="918"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1232"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="858"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="862"/>
            <end position="875"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDW80919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1456" mass="161876" checksum="E2113172CD7B0694" modified="2019-01-16" version="1">MAFPTQQSLSTQLAISNRQLEQHCNDDAFGPWSDCRLDFTIFFENTVLSMLPSIGFLLAFLIRIRALYGQDEKVLSNNGRVLKMVGNSYFQAWQDTGLDWILKPSDHFYFVGSDTSSFANLVFSGALFGFECISARMCSESSCRHWCDFHVVSRASTFSKAIYTTVQLLDYHTAARHTSASINVSLSMKFLLLVLESQSKKAILKPKYRKLSPESTSGILNRSFMWWLNGLFLQDSKRLLTESMLYDLDEDLATQASGDRLQKAWDTCSQFEGQLCFVSAVWRCFRGPYGYVVLPRLCLIALTFMQPSLIAQVINIITNEDTARSREIGCLLIFATVLIYVGISVAELHASHNLYRCITMFRSAAITLIYSRSLSLEDRLDDTNGAVTLMSTDVDTIAFCFENLNDCWSRLIEIIVGITLLTRHLGWVSIVPLIIVTFSTMGASWVTKVLGSTRRIWVEATQRRVSITTAMLNEMKSLKMMGLTDVIGETVQNQRVQETKQMEEFAWVIVWKNTIANIPFVMAPAATFAVYAVQAYFSEADFLNTTQAFTSLALITLVSNPAAGLLQAVPNVAGSIGCFQRIQKYLLENTKEDYLVALESTTIHLLDTDNNYHPVEVPLLLSPHTDPNFILVAKNITLRPSKISDIVLRDLSLSIHEGTVTAITGPVGTGKSTVLKALLGELPPVHGYVYTRTNSVAYCSQIPWLPNTTIRLAIIGPKSQLVADAIDEKWYETVLDICALRYDISKLRDGDQTKVGSNGIALSGGQKMRVALARALFARSNLLILDDVFSALDQKTQKWVFERLLGNASLVKKAGTTIVLATHSARCLSMADQVIIIGPSGTFKRGTYNELIEDGYLSGGDQEGETDSDVEEESPPEALSEEKMAKIGTDERARDLTRKTGDIEVYSYYFKSVGALPMISFVGFVVFHVLSGSFSQIWLKWWSDIESHQMLLYISVYFLLSFCYSFGNGGYVWAICVWIGPSTGRKLHKVLLDSVLRAPMSFFTKTETGILVNKFSNDMTLIESQLAFGVLATISNLVASLAEAALVATGSSHMALTIPFLLLTLYNLQKRYLQISRQLRFLDLEMRSPIYSHFLETLSGLSTIRAFGWEQESKAVNIKVVKNSQKPYYLLFCIQRWLELVLNLIVAAMAVIVVALAMNLRASTSPGLLGISLNNILSFNSTLSMFVNGWTVLETSLGAIARLKNFEATTPVEETGREDIIPDDNWPSKGRIEFKDVSASYNALEPVLEDISITILPGEKVGISGRTGSGKSTLLSLILRILPVSSGSILIDNTDISRVPLHILRTRLITLPQDVPKFPGTIRHNLYPYLPTHVSDGSIISVLQMVHLWPIIKEREGGLNADLSSDSLSKGQWQLLALARAVLQKKHMGIGNAGKVLLMDEVMSGLDEATERVMNEVVQKVFKDSTVLIVSHSREGLKDMNTVLKMDAGKIVEMER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SA46</accession>
    <name>A0A3D8SA46_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylulose kinase</fullName>
            <ecNumber evidence="7">2.7.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_04631</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 7">Highly specific D-xylulose kinase which participates in the catabolism of xylose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>D-xylulose + ATP = D-xylulose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10964"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17140"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57737"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.17"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.17" evidence="7"/>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SA46"/>
    <dbReference type="OrthoDB" id="1728974at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004856">
        <property type="term" value="F:D-xylulokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005997">
        <property type="term" value="P:xylulose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07776">
        <property type="entry name" value="ASKHA_NBD_FGGY_SpXK-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000118">
        <property type="entry name" value="Xylulose kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042024">
        <property type="entry name" value="D-XK_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF57">
        <property type="entry name" value="XYLULOSE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 7" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="8">
        <location>
            <begin position="138"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="9">
        <location>
            <begin position="303"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW83140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="571" mass="62735" checksum="DDAC7966395FF817" modified="2019-01-16" version="1">MPSSNGPLYLGFDLSTQQLKAIVISSDLRVHYEAKVDFDADLSSKYGIKKGVHVNEAEREVYAPVAMWLEAVDLVLQRLKEKNTPFDRVMGISGAGQQHGSVYWTKQGEELLGGLKTGETLVQQLSEKAFAHPWSPNWQDASTQKECDSFDEELGSENALADATGSKAHHRFTGPQIMRFHKKHPDVYRATSRITLVSSFLASVFLGSIAPFDISDVCGMNLWDIRAGKWSEPLLKIAAGEDGIESLKEKLGEVREDGGGSMGAISEYFVGRYGFNANCAIAPFTGDNPSTILALPLRPLDAIVSLGTSTTFLMSTPNYVPDPSYHFFNHPTTAGLYMFMLCYKNGGLARERIRDTLPKSTTADPWAVFNRVASGTPPLGQKTKSDRAKLGLYFPLPEIVPNVRAGTWRFTCKSDGTDLSESEESWSSEDDARAIVESQVLSLRLRSQKLVHSPEEGMPPQPRRIYVVGGGSLNPAITRIIGDVLGGTEGVYRLDVGGNACALGGAYKAVWAVERKEGESFEQLIGQRWNEEEATVKVDEGYRKDVWGAYGKVLGAFEEMEQQVLAGEERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAQ7</accession>
    <name>A0A3D8SAQ7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">AP-1 complex subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_04906</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="9">Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit APL4 and beta-type subunit APL2), a medium adaptin (mu-type subunit APM1) and a small adaptin (sigma-type subunit APS1). AP-1 interacts with clathrin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAQ7"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000030">
        <property type="entry name" value="AP-1 complex subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017107">
        <property type="entry name" value="AP1_complex_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037094">
        <property type="entry name" value="AP1_complex_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GAE" evidence="12">
        <location>
            <begin position="717"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="602"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="610"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW83415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="830" mass="90977" checksum="D03938C19DBE8A78" modified="2019-01-16" version="1">MSSLKQFIRNVRASKTIADERAVVQKESAAIRASFREESGDSNVRRNNVAKLLYLFTLGERTHFGQIECLKLLASPRFADKRLGYLGTMLLLDENQEVLTLVTNSLKNDLNHSNQYIVGLALCTLGNIASVEMSRDLFPEIETLLSTANPYIRRKAALCAMRICRKVPDLQEHFLEKAATLLSDRNHGVLLCGLTLVVNLCEADEAEGGEEGIVEKFRPFSGGLVRTLKGLASSGYAPEHDVTGITDPFLQVKILQLLRVLGRGDPQTSEQINDILAQVATNTDSSKNVGNSILYEAVLTILDIEADSGLRVLGVNILGKFLSNRDNNIRYVALNTLIKVVAIEPNAVQRHRNTILECLRDPDISIRRRALDLSFTLINESNVRVLIRELLAFLEVADNEFKPVMTSQIGIAADRFSPNKRWHIDTMLRVLSLAGNYVKEQILSSFIRLIATTPELQTYAVQKLYAGLKKDITQESLTLAAAWCIGEFGEALLRGGQYEEEELVQEVKENEIIDLFSTILNSSYATQIATEYIITSLMKLTTRLTEPAQIDRIRRILQSNSASLDVEVQQRAVEYGNLFGYDAIRKGVLEKMPPPQIKEESRVLGEATKKPNKAANRKSRQIKPADQDLLDLMGDAPATDISGNLNGSNNADLLADILGGSTSPQATSTNGPQSNVSSIMDLFGNSGPSQNASTPAPASAFGGMAGMSSPPPQASAVSIPTHPCYEKNDLNVTLQLQRNTEGMVQVLARFRSTSMQQSLSNVGLQAAVPKTQKLQLNAISSPDIGPGAEATQSMRIAGSKGPPLRLRLKISYTHPSLGPITDQVDWSEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SH52</accession>
    <name>A0A3D8SH52_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04004</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SH52"/>
    <dbReference type="OrthoDB" id="3561227at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW85679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="397" mass="43487" checksum="7028110615EED16B" modified="2019-01-16" version="1">MDDFVELGIEGIDKVVDKHFDKLPDSALHRSTYHPRQVKKLKPRRLSRRKRRPSTSSLSSEPAGGNDGFAPQGTRSGDTYTYTKGGQGSGTPYSTLPSRIRPEYQPPLENPYVDRSYYSASPVNTGYNPQARRGDRTDSPRTLDDDYYSESRNARPRMASRRSNSLGAPKRPQDSIILSEQRLKDRRRRKSHGYDSDSDGWSRGGSGGRGGGGSGGGGGGGGSRKGSGRGNPGKGNGLEDKLGEVFTDSNIGLGAGVLGAVVGGWATSKAQVAGGVDKVDSSKRRNQSNTLMTVLGAAAAGLAANALVDRWEENKKKNKAEDDTWNEKHGKSEIGKEREKFTGRGIDSDRDRDRDRRKEFADYRRESDRRGHRSRRDDGYLAEGHGRGYEPLSDEYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHD2</accession>
    <name>A0A3D8SHD2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_04082</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHD2"/>
    <dbReference type="OrthoDB" id="5426978at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF26">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="138"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="205"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="263"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="376"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW85757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="752" mass="82405" checksum="5C032FE98154FA40" modified="2019-01-16" version="1">MNNHSDAPNMQSYPSPTAHPADNGGPFYASSQGQPSANMSTPEELQLAAQLSRNMAPNMGNSSGMEGISQDMRGQQGISNQYQPEPQGHNLHDPQQQQQMHHQSAPAAAMAQMGAQYNGSPLPDAPGSNRKRSKVSRACDECRRKKIRCDASEESGEGVQCSNCKRVGSQCLFSRVPQKRGPSKGYIKELADRLNTLETTLHGGEISQHLPQESPYQQQPQRRPSEEYSPIPMQNEQPRKRSFSSFSNDLNPAYQTPRAAPGWSNQDGRHTYQQPVPSGTPQEFREANYSPGGVQSGGPWSNAPEAARRLSITAQNAPQAEMMRNPIDASMVQDYYDIIHPTFPILSPSDLDSIAKFASPADRYSFNNSLINAIQSFPSDPTQPRQTNPIPIAKPGNAKYNSRSAELTRLQSLMFQIIAAGNLDPSDARRHTKSSPSTLLGSAVGFAYSMKLHVHKAMDSIMQADPDSDEHHERRLWWILIVMDKWHAASTSSPVFIPDTSIVIYPDEDSTILGETLYHLSRMSIVLGHLSLVALIQPSDMPPMAAPVASALGTLSRGELERIREDLPASFFPPSSCPWIHFCYWSLRILVELRNPDSDPAQGLLDPALNLVTQLTFNRAFVGPLTHYASTLVVLALIELLKYDRTKAEATTALKSLYTAGPAPSAFDPVSRALIAKKVPSLVSSSTGEAPMTDSQNLQHLAELATGQAEKGKVANEATTTTPNIFKHYSSLRDIIHKGWMNAVLESVNTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHF4</accession>
    <name>A0A3D8SHF4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">hydroxyacid-oxoacid transhydrogenase</fullName>
            <ecNumber evidence="4">1.1.99.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_04058</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(S)-3-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + acetoacetate</text>
            <dbReference type="Rhea" id="RHEA:23048"/>
            <dbReference type="ChEBI" id="CHEBI:11047"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>4-hydroxybutanoate + 2-oxoglutarate = (R)-2-hydroxyglutarate + succinate semialdehyde</text>
            <dbReference type="Rhea" id="RHEA:24734"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16724"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57706"/>
            <dbReference type="EC" id="1.1.99.24"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.99.24" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHF4"/>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047988">
        <property type="term" value="F:hydroxyacid-oxoacid transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08190">
        <property type="entry name" value="HOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000009">
        <property type="entry name" value="Fe-containing alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000003">
        <property type="entry name" value="Probable hydroxyacid-oxoacid transhydrogenase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042157">
        <property type="entry name" value="HOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF83">
        <property type="entry name" value="HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="9">
        <location>
            <begin position="79"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="10">
        <location>
            <begin position="301"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW85733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="499" mass="53873" checksum="EB32087C45AE7943" modified="2019-01-16" version="1">MVSPVRVAPSAATRAMNLLRTVTYTHPPSCPCHGNPAHHHHHKPSSGLLAQTQRNLQRNYATPIDTTRQKEYAFEMAASSIRYGPGVTKEVGMDFKNMGAKRVCVVTDKTVRGLNAMKQVEEGLTREGVEFTIYDGCRVEPKDSSIKDAIAFAKPYQPDAFLAVGGGSVIDTAKLMNLYTCYPNADFLDFVNAPLGKGLPIDKPLKPLIAVPTTAGTGSETTGTAIFDLVSKRAKTGIAHRNLKPTLGICDPLNTRTMPSAVHASSGLDVLCHSLESWTAIPYFERTPRPTNPINRPAYQGANPISDIFSLQALRSTVKYLPRATKDPEDFEAQSQMLLAATLAGVGFGNAGVHLCHGMSYPISGQNPGYKHAGYQVDTPIIPHGVSVAVSAPAVFRFTGPSNPERHLQAAEAFGVDISNVKKESAGEVLGEALTKFLADLGDQPKGLKDLGFTREHLDDLVEGTIPQARVLMLAPGLAEEVNEEREQLRNLFEAAMTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHY7</accession>
    <name>A0A3D8SHY7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_04290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHY7"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="91"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW85965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="329" mass="36280" checksum="BF98A6AE0AC67FC0" modified="2019-01-16" version="1">MSSSSVEPAPNYIDPEFAAIKDECDAQNVKLAALSFEDFVATWRVMPPALPGECPTDIEITDRTATVSDGSGIEIRIYKSKDVKPDAWLFLTCHGGGWTVGSHEVEGGNNRYVASKTGCVVVSPDYRMAPEYPFPYPINDCFDTLKWCKANAASLGINPEKIIIGGSSAGGNLTASVAMRARDEGVSGIRGQVLNIPNICHPKLFPKDKGYKYESTKEFEVCSMLNTKEMTWYWDKYLPNLDNSVRACPILAESFKDLPPALVQVAGMDPLRDEGFAYAKALKDDGVPVTEYFFAGLPHCFYFFPNLTKTAEYYANIVSWVKEVQNSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SLR9</accession>
    <name>A0A3D8SLR9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Berberine/berberine-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_02944</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SLR9"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF22">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW87250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="251" mass="27604" checksum="2EC814B4A7372508" modified="2019-01-16" version="1">MVNFELVTGAGEIINVNASSNSDLFVGLKGGVEEAAIYDEILVIPDLIASSMRITNVSSLTDELSAASTANTRNLFLTATFNNSAKMYETYINISNVHLEPLKNTTGLTWSLLFQPIPRIVSDHSIAARGNIMGVNRNKENLILFLIYITWHLESDDAKFTKAGYTTLNEILATGEELGVSNPYVYLNYAGKEQDVLAGYGEENIGKMQTLSKKYDPAGIFQSLVPGGWKILFHNLYDMSAGTKTTHNLCY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SM17</accession>
    <name>A0A3D8SM17_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_03059</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SM17"/>
    <dbReference type="OrthoDB" id="4763033at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW87365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="21348" checksum="4AFC9353A08D161A" modified="2019-01-16" version="1">MIPGTTVPPHFHTRFAETFDLISGSMLVYSSTSPDLDTPDASAQQQKIGEEVTVQPRIYHKYVAGDEPTVLRAIVMPGDGDFERLLMILNGMDADGELRKMGDSVVLMGLSDAHLIGPAREMLEKVLPENKDEVEALKKGHIDNRLRFCRLDPRSSPILPYHEQRLRVSSRLLVSFSTGAPSHLDHAQTFKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMA5</accession>
    <name>A0A3D8SMA5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03096</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SMA5"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW87402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="219" mass="24421" checksum="C99E2797F747B93F" modified="2019-01-16" version="1">MNEPCSHPWKVRRLSNGRRLAPPLPRTPARGRNPSPSKSHLRESALYNAARLVYLGGAVSYIRQGIGGFERDYLSVSGDTPADTGLWQDLRVAIHRATRLALDRPDATTIIAEQHNLNPDDLQPCHILRPLKRVVHGADVAPPEQLIAIQSPITDGLESNGSFHDHDRRLLLQVPSIVQAIDSSKFERVFACFANINRRRRRNTLKAGDDAMFYDHGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SND3</accession>
    <name>A0A3D8SND3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_03529</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SND3"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="187"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW87835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="354" mass="40527" checksum="AD6234E7AFD52E8F" modified="2019-01-16" version="1">MGSMEEPQLDKLPVIDFANWREDSTPEQRYQVAKELADACHNVGFVYIINHGVTPDLLEEAFSWSKRLFDLETEKKMLAPHPDGPTVHRGYSWPGLEKVSQVISTDMELGEKLREVRDCKESYEIGSDENEEQPNVWLPDEVLPGFRKFMTNFYWECHKTSREILTAIGTGMHLQDPEFLLRFHAGHNNQLRLLHYPPIPAVELEEESSARMPAHSDWGSITMLFQDDCGGLEVENQHKAGEFIKALPIKNAIIMNIGDLLMRWSNDYLKSTLHRVTLPPASDRYTGTERMTRARYSIPYFISPDIDAVIECLKECASTTNPARYGPVVQREYRLMRAKLQYPEKSAPSTPIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SPZ1</accession>
    <name>A0A3D8SPZ1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate decarboxylase</fullName>
            <ecNumber evidence="4">4.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BP5796_03562</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 2-oxocarboxylate + H(+) = an aldehyde + CO2</text>
            <dbReference type="Rhea" id="RHEA:11628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:35179"/>
            <dbReference type="EC" id="4.1.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.1" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SPZ1"/>
    <dbReference type="OrthoDB" id="3970464at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000019">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF11">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="10" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="15">
        <location>
            <begin position="6"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="13">
        <location>
            <begin position="202"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="14">
        <location>
            <begin position="407"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="488"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDW87868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="581" mass="63937" checksum="0F95197B19AC8AA0" modified="2019-01-16" version="1">MPPTVKLAEYLFTRLHQLGIQSIHGVPGDFNLELLDFVEPSLRWIGSCNELNAGYAANGYSRINGLGALITTFGVGELSAVNAIAGAFAERAPIIHIVGTPDRAVQDNRTQIHHTFNDGNFRRFALIHAQITVAQANLIDPRTSPAQIDAVLEQCLIHHRPVYIEVPVDMVTAPVSAARLASPITIPEPIPSRHRPEALALVLQRIKASQRPMIFVDGETNGLGLRKELHELLEKTHWPTWTSPFGKGLVDETLPNFHGVYMGKEKMHQKSFIDACDLILVFGPHFSTTNSFQKTAVPNPAASISFAHTAIHIGDRKFEDVLPKQFLVDILQALDEIPNVTKYEPYPELETPQGLVRSTCLTPGDGPLTQKEFYLRLSPFVRPGDIVLGETGTAGYGTREFALPRDTWYMGPVTWLSIGQMLPAAQGAALAQSEREAKSSKAEGGSKTKPGRTILLIGDGSLQMTVQELSTIIRENLNVVVFVLNNNGYTIERCIHGLNQKYNDVAAWRYLEAPNFFGAKESAQSSTFTVQNWADLSRVMADKNLADGEGLRMVEVFLDQDDAPAGLLRLLALQVEAQKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXN9</accession>
    <name>A0A3D8SXN9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 5B</fullName>
            <ecNumber evidence="3">3.6.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Translation initiation factor IF-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BP5796_02240</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SXN9"/>
    <dbReference type="OrthoDB" id="4928at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03703">
        <property type="entry name" value="aeIF5B_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000013">
        <property type="entry name" value="eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000112">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029459">
        <property type="entry name" value="EFTU-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003078">
        <property type="entry name" value="PRK04004.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14578">
        <property type="entry name" value="GTP_EFTU_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 15" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="14">
        <location>
            <begin position="468"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="204"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="123"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="156"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="204"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="313"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="363"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="414"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDW91075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1064" mass="117190" checksum="0DD2933EA221A9AD" modified="2019-01-16" version="1">MAPKKKNNKKNDDWEADLGETPEQAAPAAAAEPETKDDPAEADPEDEFPAGGLMAMLRKKQKKNKAKQQDFVEGEDPAAEGQDAFQAPAEASIEDEFALPEKKGKGKKPAAAQEEEGDDDEKGADGKMLTKKEKEKLKKEREKQRKKENAAKKKTSAPAAKAAEPAMAVEEAKVEAAPVPVAKPAAGGKAKKLSPALLKLQKEQEALRQRQEEAAQRAAEEKARIEEEERREAEEERKREEAKALKKQKEREKIEQQKKDGTFMTKAQREEKLKREMKLKQQLAAGVKVAGLEGAGEKKKSANDYRKKKSGKKNPEEIKAEEEKALAEAAERARLEAERIAAEAAAKVEKEAAEAAAKAKEAEDSELDDWEVAAAESDDDVKESWDADSEEEREKAEAKKSAAKTSLPSRPKEEDDEDSEEDSEDEESSDDEEATAAQAAAAQRKKEAAERREKAHEAAMAARSKDNLRSPICCILGHVDTGKTKLLDKIRQTNVQEGEAGGITQQIGATYFPVDAIKTKTAVVNRDNSFEFKVPGLLVIDTPGHESFSNLRSRGSSLCNIAILVVDIMHGLEPQTLESMKLLRDRKTPFIVALNKIDRLYGWKKVDNNGFRESLALQNKGVQNEFAKRLSDTKLAFMEQGFNAELFYENKSMSKNVSLVPTSAHTGEGIPDMLKLIIQLTQERMTGSLMYLSEVQCTVLEVKAIEGFGMTIDVILSNGILREGDRIVLCGVDGAISTNVRALLTPAPLKELRLKSAYVHNKEVKAALGVKISAPNLEGAIAGSRLMVVGPDDDESDIEMEVESDLGALFSRVEKSGRGVTVQASTLGSLEALLDFLKSSKIPVANVGIGPVFKRDVMNCGTMLEKNKEYAVMLCFDVKVDKEAQQYAEEQGIKIFTADIIYHLFDAFTKHMAEILEKKKEESKLLAVFPCVLKTVGVFMKSNPILVGVDVEAGQLRMHTPIAAVRQNAVTGVKEIVSLGRVTSIQREHKQIQGAAKPGQASVAVKIEMGGHQPMYGRQLDEKDTLYSLISRPSIDCLKDYYRSEVTNDEWNLIKKLKPLFDIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXT2</accession>
    <name>A0A3D8SXT2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RanBD1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_02235</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SXT2"/>
    <dbReference type="OrthoDB" id="185618at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF142">
        <property type="entry name" value="RAN-BINDING PROTEIN 3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="4">
        <location>
            <begin position="382"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="261"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="345"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="62"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="183"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="271"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="355"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW91070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="550" mass="57559" checksum="9FC93F03C950EB66" modified="2019-01-16" version="1">MTSKVSADAVPDTTTQDAKPLAEVSDIMGSNHHKEGSASSAGALPEIPAQEKEDPATMAASEELRHTSISEGTKRPPQNDVAGTEAGNADGDKHMEGTQKETTPPIRFAQPTETQDNEMRERLSSPKKKRGRDQDDDEEYSDDSKIDDVASADATTNGGRTTRLEPEKKRHRDTSNTANAETDSSKIETVREKVTEEGIKATSTTPIFGSGSGDKPQTSASAFASSGFGALASSTTSPFGVIGASKPSVFGGGGASASASPFGALAGSSSTNSPFGASKPSESSVFGANKPATASGFGASTSSFGGAAGQKSAFGSGLSNGFGAGAPKLSSFAAPGQNSVAITSAKPAKAFGAPDSDEDETSNGEDDSDGDGAEEEEGEKLNAEDKKKFKTKVPIDDGEAGEATLLQFRAKLYTLESKEVGWKERGVGTLKVNVNKTCVDMSENGQPDPMTLDFSSMDSEDNKDSNIPAARLVMRQENTHRVILNTIIVQAMEFKEKPSSASAVQILFTALEGSENELKPVNMLLKISEANANLFTKEIEHIQHELKDLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SY20</accession>
    <name>A0A3D8SY20_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Iron-containing alcohol dehydrogenase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_02397</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SY20"/>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08192">
        <property type="entry name" value="MAR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF107">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G06800)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="2">
        <location>
            <begin position="34"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="3">
        <location>
            <begin position="203"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW91232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="546" mass="59039" checksum="D93D0FD8EB124631" modified="2019-01-16" version="1">MAAEGEVYRLAFPPKTKPHISTGIAFPAATAYHVANTFHASKVYVIVSSSISKTDNFTALQNALGDKIVGVRKGIKPHTPWDDVLDIIKDLKEKQADLIVTLGAGSLTDGAKVISFALANNATVEDDLERLTAVAKTPDLKPCKIPVINIPTSLSGGEFSPFAGATDKRTNHKKSFAHPSMGADLIILDPALSISTPARIWLSTGIRAVDHCVEGLCSTHPKASAETDRGFAAGLKLLVPNLLITKENWDNEEARLNEFLGVVEAMGAIGHGVPMGGSHGIGHQLGPLGVGHGETSCIMLPAILKYNYKYGDERVKGNQRKVLDILWAEPAVEKVLTARGLSKETADGGDVLEAVITELGMPTSLKDVGVGRDALDALAENCLKDRWLPTNPVPLTEKKQVLEVLEMVVGDDKSSFNTISTQSGAYIYPCPALQINLNHDDSRYSSLRLNRRRCERDSNRVDDAQPNFPQVGEIFEVTSISYYDDVFAKLVEALLVCESGSPDHTTDSSGKLGELDKGEHVLRFHEPQHRDAATRWEQGLQSGLCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYA7</accession>
    <name>A0A3D8SYA7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Aldehyde dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_02404</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYA7"/>
    <dbReference type="OrthoDB" id="440325at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006081">
        <property type="term" value="P:aldehyde metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07135">
        <property type="entry name" value="ALDH_F14-YMR110C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000025">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000004">
        <property type="entry name" value="Aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012394">
        <property type="entry name" value="Aldehyde_DH_NAD(P)"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43570:SF11">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036492">
        <property type="entry name" value="ALDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0520">NAD</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="7">
        <location>
            <begin position="5"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR036492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR036492-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW91239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="536" mass="59289" checksum="4A65A6792129E1CF" modified="2019-01-16" version="1">MAPKIAEFTSTSIDTIAPTVARLQATFASQKTKPIEYRLQQLRQLYWGLVDNADLVLESCRLDLGKPELEVVYTELDWCKNDAVFASKNLAEWMKDEKAPDIPLTNTFVAPHIRKEPLGTVLIIGAYNFPYNLAFGPLIGAIAAGCPAVLKPSEGSPYCAMVMKKIVEESLDPDAYVVVNGEVPETTALLNEKWAKIFYTGNDRVARIISKKAAETLTPVCLELGGRNPAIITKHADIRLAARRLLWGKALNAGQVCISHNYTLVDKEVFPQFIEELKAAWKEFYPNGIKASPDFGRIANNRQFLRIKKMVDESKGKILMGGEMDEATNYIELTVVQVDDVNDSMIKDESFGPLMPIYPVENLDEAIRIANTVHATPLALYGFGTKAETKRILNEVLSGGASINDSFFHASIQTLQFGGVGDSGQGAYRGRASFETFTHRRAVTTTPNWMESLLSIRYPPYLGKIKQARRMQELKPDFDRNGKVVKGVGYWVKFVLGLGASSAKGSVLRWVLLAVIAVTTNKYLGQGNGGLPNYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYZ2</accession>
    <name>A0A3D8SYZ2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative 3-hydroxyacyl-CoA dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_02708</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-hydroxyacyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYZ2"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022694">
        <property type="entry name" value="3-OHacyl-CoA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006176">
        <property type="entry name" value="3-OHacyl-CoA_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006108">
        <property type="entry name" value="3HC_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075:SF3">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48075">
        <property type="entry name" value="3-HYDROXYACYL-COA DEHYDROGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00725">
        <property type="entry name" value="3HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02737">
        <property type="entry name" value="3HCDH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000105">
        <property type="entry name" value="HCDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase NAD binding" evidence="5">
        <location>
            <begin position="15"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyacyl-CoA dehydrogenase C-terminal" evidence="4">
        <location>
            <begin position="189"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="3">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000105-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW91543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="286" mass="31878" checksum="9F4DD68A16640298" modified="2019-01-16" version="1">MAYTWTAPDVTKRPVAIIGGGVLGRRLCMMWSCAGNEVVLYERIPEVAAAAVAYVDENIQAQIDVVKGKRGILRLASSMEDAVSNAWMVIEAVPERLEIKIPLFGELDRLTKRDCILATNSSSYKSSQMIEQVERTYRVCNTHYFMPPAMNPVEIMSCGHTDVAVVEHLLKVAKPVGLFPIHARKESTGFIFNRIWAAMKRESLLVIKDGVATPEDIDLMFKENFGAKIGICELMDTVGLDTVYNIEKHYVEERLLEPTTLDWLKETYVDKGNLGHKSGKGLLGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYZ3</accession>
    <name>A0A3D8SYZ3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GRIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_02697</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYZ3"/>
    <dbReference type="OrthoDB" id="425925at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019459">
        <property type="entry name" value="GRAB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000237">
        <property type="entry name" value="GRIP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921">
        <property type="entry name" value="MYOSIN HEAVY CHAIN - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18921:SF2">
        <property type="entry name" value="THYROID RECEPTOR-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10375">
        <property type="entry name" value="GRAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50913">
        <property type="entry name" value="GRIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GRIP" evidence="6">
        <location>
            <begin position="474"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="185"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="521"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="576"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="368"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="80"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="185"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="544"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW91532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="606" mass="67231" checksum="3F555A76E77F2AB4" modified="2019-01-16" version="1">MSAVAPSDSTSQTLSAPKKKNNKKKKGAKDKSNGDTKTVPEITKDDSAQLGDHDGDGDAQESGASGPNTPIDAQFPESAAQINGHSESTSSNGHAIAPSSKPTAEVGTGTQNLDHAPESVKSTATDTTDASVRLEAMSQEREALRVEVEQLRKSLEDIQGKHNEEVSSIKDQHAEELSNIHGKHNEEISQIKGQHTDELSGLRGELEESESAKEQAESQYQNLLGRVNTIKASLGERLKADRQELSEANEKIEELESQNESFQNRIETLEKEAAKLEQESNDATRELSSLRSRHNLSQQNWVSEREDLLHQIRQLREEAEAAKEAMGDWEVLAMEERSIREGLSERVTDMEEQFSSQKEAFEAAVAERDSQSRTADGLQRALQELQEARKRELRDMVESYEEQLQSLKKLVQESEARAVEAVSAKEGLQAELDRLTPFEKEVKEKNLLIGKLRHEAIVLNDHLTKALRFLKKAKPEDNIDRQIVTNHFLQFLALDRSDPKKFQILQLIASLLNWTEEQKEQAGLARPGTSNNSLRLPVSPFHRTPSTPSLSTEFFTESGDRKESLADLWTGFLERSAEEGSTHGSRNGSISGLPATRPDTKGGPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZI0</accession>
    <name>A0A3D8SZI0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_02887</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZI0"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017496546" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="26"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="31"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW91722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="580" mass="62190" checksum="6372FC13A56109A4" modified="2019-01-16" version="1">MLYSVGNTAVVLATTVIALSSVVSSRSVNTAPTVTVKNGTYVGRHNAAYAQDLFLGMPFAQPPVGDLRFRAPVSLNSSFHGVKNATVYPPECVGYGSDNIPYVNSEDCLYINVVRPSGLAPETSLPVLFWIYGGNNEEGGSGDIRYNLTFLVDRGVQMGKPILAVSSNYRVSAWGFLGGKEALAGGATNAGFRDQRLALHWVRENIKAFGGDPDKVTIVGESAGAEGVGAQLLAYRGRDDKLFRAAISESGGPAIVAPLAVGSLNSSSQQATYNTLVTNTSCASTFGTSRSLECLRKLPFAELNAALNISSSGLTPFTPQIDNDFYATYPSDQLNNGEFVKVPYICGSNTNEGTLFSTIVSYNGSAIINTDAEFERAIQQVSNLSTNATRTLAKYYPNDPSIGIPSLAQYPGSIDSFGLGSQLRRVGSYAGDWIIIAPRRATNVAWAAHGVTTYSYRFDVTPGGLSARYGPAHFQEVAFVFDNTDGLGYASNPFGSGLDNSTIAAYKDLAKLMSSSWVSFVHDLDPNQNGIHGALNWPKYATQNPQHIVWAANGTYIEYDNFRAEGMKYMAQIAKSEYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZI6</accession>
    <name>A0A3D8SZI6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Aryl-alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_02746</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZI6"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF213">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017802582" evidence="3">
        <location>
            <begin position="19"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="367"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW91581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="659" mass="71144" checksum="863A8901D83648BA" modified="2019-01-16" version="1">MVSLRVLGLLGLGAAAVALNTTTATNATTSLEDYEYVVVGSGPGGGPLASRLAIAGYKVLLIEAGDDQGDELTAKIPAMFLQASEFEPMKWDYFVQHHDNLTEQERDSKMVYEKTDGTWYVGLDPPADATPLGIWYPRAGTLGGCSVHNAMITIYPHESDWNNIANITGDSSWEAANMRTYFERLERNRYLPSSVVGHGYNGWLETSLTDLRLVVEDLKLTSLIVSAAAAIGKTVLTALLSTVVGVSGVLTEDINGGLPGRDANTGLFQVPIAVTNDNKYRNGPRDFILETAYAVNSDGSRKYHLDLQLNTLVTKIRFSQNGTTPVATGVDFVVGNSLYRAAPGSENATISGAGSVNATREVIISAGTFNSPQLLKLSGIGPKAELEALDIPVLVDLPGVGTNLQDRYETSVIGKSPTNFTITEDCTFLNTTNDPCRVQWQNDDLFKGVYGSNGIAIAIIQKSSAAAEDDDPDLLISAAPANFPGYYPNYSNIALSDAKHWVWIVLKAHSRNNAGTVTLKSTDPRDMPQINFRYFDVGGDLDMQALYEGMELSRRGFSDLIPLDGDFTETWPGSSVQTEAEMKDFIRREAWGHHASCTNPIGADDDPMAVLDSNFKVRGVQGLRVVDASIFPKIPGFYIALPTYIISEKAADAIIAGAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZQ1</accession>
    <name>A0A3D8SZQ1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative oxalate decarboxylase oxdD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_02403</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZQ1"/>
    <dbReference type="OrthoDB" id="10263073at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033609">
        <property type="term" value="P:oxalate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20305">
        <property type="entry name" value="cupin_OxDC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20304">
        <property type="entry name" value="cupin_OxDC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017774">
        <property type="entry name" value="Bicupin_oxalate_deCO2ase/Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051610">
        <property type="entry name" value="GPI/OXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03404">
        <property type="entry name" value="bicupin_oxalic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848">
        <property type="entry name" value="OXALATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848:SF9">
        <property type="entry name" value="SLL1358 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017682898" evidence="4">
        <location>
            <begin position="23"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="5">
        <location>
            <begin position="155"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="5">
        <location>
            <begin position="335"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="196"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="241"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="382"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="387"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW91238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="522" mass="55887" checksum="283AEFFD97A88508" modified="2019-01-16" version="1">MPRLLKLSYISLLASILPNASALPAPQLSYGENSGPVGGVNPAALPTVTTSLGSLYGNEQLLGGVARPSPVSGGDSAVVSEYPLVNGQLADSKLGLYLDFNSVEDPQPIRGTLGQTDPGPGDFEYEKLNPDRFAPPGTDSGSLPNAMWPLALSSNRLGSGKTSGWARQQNIAQLPAATEMAGVDMRLAPHAYRELHWHTASEWSLMLKGCVRLSAVNENGESFIDDICAGDVWFFPAGVPHSIQALDEGAEFLLVFDNGDFNEDGTFLVSEMFLRNPKSVLSKNLETPVSALADLPSGELYHFQIFNGTPAPANISEQNITSSAGSLPVDQSFTYHFSQQEPYVVPGGSVKVIDSTTFPVAANFAAALVTIQPGAMRELHWHLTSDEWNYVLQGSARITIYLAPDSSQTFDYTAGDVGYIPAANSHYIENTGTEDVIFLEVLQAPKFTDISVAQWLALTPKQVVQDTLHLPDETLAGLPKEKTYLKPGNRNLTALAADPNGTSAYDESTPGAAKRRAIAFST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZU9</accession>
    <name>A0A3D8SZU9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_02866</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZU9"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF24">
        <property type="entry name" value="NICOTINIC ACID PLASMA MEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="49"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW91701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="487" mass="53296" checksum="F9261ECAD6064D81" modified="2019-01-16" version="1">MEPEPTMEKSSKVIDTSDYVDYGSGDAGPVIYIDPAREAACRKKFDKYVVPVSVIFLVLSTLDRNNLGNARVFGFDEDLGLHGGQFGNINTLSSVCTILFEVPWVMAVKRWGANKSIGTAFVLWSACTLGTAFIQNYAQAIIVRMLLNAAEAGLAQGFAFLFSTIYPRELAGKRIMTTNLAQCISGAFGGLFAYAIQTMGDRNGFAAWRWLFIIEFLITVVICGIGWVFLPSAPETAWFLNEEEKETMRLKKQRDFMLRGDDAFDRKWIKLALTDPFVYLLGLAFFTSSVAINGFGVFLPTIIAGLGFASLKVNYLTIPVFILGAISLTIQVYYSDKTKKRGVFIIGCCVPVAIGYLICVGTPNPNAGYAGMFILVIGLYPISTLAVTWIATNLSPDSKRAIGMPFAYSIANVSNLISSQLYPTQQGPRYVQGNAVSAGLTVVAGFLYGACWLLLRYRNTKKEKLIAEGATTNGLEGDMSLDSMYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZY2</accession>
    <name>A0A3D8SZY2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_01234</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZY2"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="119" mass="13001" checksum="E62E42D8A1278F96" modified="2019-01-16" version="1">MGASSNKVSWNVSGGKVDDGHFEEVSAAASGGTDHEMLLANVRDGSFSSEIALLEKSSYRTVFDIQWGLATIIIIAALIVPENPVYLIKRNKLYSTSKTCQRLSPNAEANEDSLFVRHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T022</accession>
    <name>A0A3D8T022_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Carbohydrate esterase family 16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_01288</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T022"/>
    <dbReference type="OrthoDB" id="1600564at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01846">
        <property type="entry name" value="fatty_acyltransferase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001087">
        <property type="entry name" value="GDSL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051058">
        <property type="entry name" value="GDSL_Est/Lipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648">
        <property type="entry name" value="GDSL LIPASE/ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45648:SF22">
        <property type="entry name" value="GDSL LIPASE_ACYLHYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G14700)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00657">
        <property type="entry name" value="Lipase_GDSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="394" mass="43682" checksum="14B6395589CABF94" modified="2019-01-16" version="1">MSGYLQFLPFAPKHFAPPHNGLLEQFIAKMHSLTEMWNLLLQFLSAGGAVPAALPVHRPGSLSNHSWVTDFSNLVTFGDSYTDESRLQYFQTHNGSAPPPGLLLPESNSTAGGGITWSRFVSTNTGAKLYDYAVNGAVCSNEIIFRLLTSIHMPFPDVVYEVDAFEADVTYVNTATGTNTLYTDRQPENTVYSMWIGTNDLGVNAFLTDSSLNMTTIPDYVDCIFDRFDDIYGSGGKYFVLMNTAPLQLSPLYGMPGEGGLATSSYWTDKASRPPSNTSEISGKMKEYTQLVNTIFDYRVPFELKIAKRYPGAKMAIFDINSLMTDMFNNPSQYFTAPANVTGTYTGCGKSSCPYSLDHFMWYDDLHPSQRSDEIIAIEFAKVVDGSSTYAVYW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0G5</accession>
    <name>A0A3D8T0G5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADH-ubiquinone oxidoreductase subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_01456</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the complex I NDUFA5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0G5"/>
    <dbReference type="OrthoDB" id="286811at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006806">
        <property type="entry name" value="NDUFA5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12653">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 13 KD-B SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04716">
        <property type="entry name" value="ETC_C1_NDUFA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0830">Ubiquinone</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW92062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="253" mass="28365" checksum="A1D7AD36ADA36391" modified="2019-01-16" version="1">MRRTCRLLAAVKPARYLESGTPTGLTGLFTHHAPRSTLMYLYSSTLDKLKEFPESSLYRTSTEAITKHRMQIVEATIPPGYEAWKAKAEKIIAENPEVFNTPAGGVDHDGGRHLKQMANGRVFVHTKIDKPYDEYSTEWDGEKAPTVLEGTRTTEERKYQSSLAAERPGDDSKTITWESEPALTAQQIEEVENKIGAGLIEEVIQVAEGELKLVDVMLKSKAWEDLEDKPVEGQWTYFTRDTATPPSQAPPQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1E3</accession>
    <name>A0A3D8T1E3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">High osmolarity sensitivity protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_01713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1E3"/>
    <dbReference type="OrthoDB" id="3358869at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042332">
        <property type="entry name" value="Hsk3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013183">
        <property type="entry name" value="Hsk3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28289">
        <property type="entry name" value="DASH COMPLEX SUBUNIT HSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28289:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT HSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08227">
        <property type="entry name" value="DASH_Hsk3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW92319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="89" mass="9309" checksum="04838FEE96DDB79D" modified="2019-01-16" version="1">MSSRIPSTATQRRLSAAPSSIKPRQLSHLHAQLARLQANLADTESLLRMTSVQAESIRGLGAFHGGLLMAASKVLGEETVAGGAQGSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1H0</accession>
    <name>A0A3D8T1H0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative DNA excision repair protein ercc-8 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_01819</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1H0"/>
    <dbReference type="OrthoDB" id="361494at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000109">
        <property type="term" value="C:nucleotide-excision repair complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042238">
        <property type="entry name" value="Rad28/ERCC8/Ckn1/ATCSA-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46202:SF1">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="66"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="209"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="277"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="435"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW92425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="468" mass="50855" checksum="FE1A825A3D865B7B" modified="2019-01-16" version="1">MNQLLLDRSAGNIGPQAFARLYTSQLLNAIQYAPKLGFDGGEKEVNLEESDTIIREASRVAADKKIWAHQSGVNALAIDRFEGRILLSGGVDASIKLWSLGEVSNASSAHALHPTGNIKKDQSSAHKFGITHLSFYPFDSAAFLSSSYDHHLKLYGTETLQVAGSFDLSSIVYTHAVSPIASHLLVACATQHPAVRLVDLRTGASTHSLAGHHGALLAVAWNPRTEHNLASGGIDGTIRLWDIRKSGGSLGVLNMEDSLGITGTDGWGTGARSREAGKSHQAAVNGITWTDDGSYIVSAGHDERIRVWDAATGANTLASFGPSPKNSHVSNLPLLPTPTTLTLPGQTLLFYPNEQEILVFELHEGRLLKRLKVPGPSIAAVRSRTGERNVRNRITALAWRGAADGFYSAHMDGQIRAWIPRTKDDDSLDKEEEEAYRKDEDESEGSKRKRKVLDDVFRDLTRQKISFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T227</accession>
    <name>A0A3D8T227_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T227"/>
    <dbReference type="OrthoDB" id="5428081at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="52"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW92616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="96" mass="10742" checksum="3785709D4EB49A65" modified="2019-01-16" version="1">MSRQQTIRRVVWTGAIASTTAVGAWYGAGLKTQQEIKTEIKKRHEATPAEKIAQLEESRGALVAKRLALERKIEEIERRKGGATLAESKVGRERTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T2B8</accession>
    <name>A0A3D8T2B8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_02043</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T2B8"/>
    <dbReference type="OrthoDB" id="4158087at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW92649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="476" mass="54233" checksum="AF1A5359A1042321" modified="2019-01-16" version="1">MQYNSPNYQQLGMMNLPLKVVQDDQGRFRDINNQPMIMILNNKARHPRTSGRLNRAKEKSRMAGPKPFEFINITKPDNGSEDEEVRTLIRTHVMRSLNRRERRKCSSSLHTSPGCIFPPQDILLPMIPPQPPAYGPTFIPFPVQMQPYMRRLIHQCATNPRQHATPADSAWFPMAMSDPALFHAILCTSAIYIGLISGQQDLYPQHRHMLEAISLINTRLRQINTSECVSDSTITTVLFLAKAEARFVTQDTELIGCIETGFVPRFTFVDGPTTIGPSISLTSLTPGIQSLTKNHLLDRSLFALLMGLENYSRNFEDKTALTVDLESTAVYLRYQLLSWTDHNSSTDQRSVVQQVIRIGAIVHLDSLLGQPSIRGIDYTVMLSRLRAYLLRFQTTCVATRDLLLWLLFMGGSTSGNPCRAWFIAKMLDVTTQAGINVWDDAKLLLMRFWWVESLYEGPWQQFWEEVRAIKINVLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T388</accession>
    <name>A0A3D8T388_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Copper acquisition factor BIM1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_01852</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <topology evidence="1">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T388"/>
    <dbReference type="OrthoDB" id="2146436at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21176">
        <property type="entry name" value="LPMO_auxiliary-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046936">
        <property type="entry name" value="BIM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046530">
        <property type="entry name" value="BIM1-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992:SF1">
        <property type="entry name" value="COPPER ACQUISITION FACTOR BIM1-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34992">
        <property type="entry name" value="HYPHAL ANASTAMOSIS-7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20238">
        <property type="entry name" value="BIM1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017534989" description="Copper acquisition factor BIM1-like domain-containing protein" evidence="8">
        <location>
            <begin position="18"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Copper acquisition factor BIM1-like" evidence="9">
        <location>
            <begin position="16"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW92458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="211" mass="20893" checksum="B0F58A17CC90A670" modified="2019-01-16" version="1">MRSQVLLTALVAGTASAHFNLDYPAARGFDEDKLGTFPCGSFDTPVTNRTVWPISGGEIALTMGHITANVEVFIGFGNNVGSAFNTVLRPVFAEQGLGAFCMTGFALPAGMTVTDGMNATIQVVTNGDPDGGLYNCADITFSSTASAPASGVCTNGTGVTAMAATSTAQPNGTTASTTGSSATSTKSSAANSVAAAGGMVAAAGALLAAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T830</accession>
    <name>A0A3D8T830_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_00482</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T830"/>
    <dbReference type="OrthoDB" id="5244050at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="621"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="399"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="487"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="550"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="621"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="645"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="686"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW94719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="801" mass="88108" checksum="F14BBE5189FB9F42" modified="2019-01-16" version="1">MGGRSKFSFPIPGRKHTKENKPRRVPQSPVSVTSSSGLSKAQRLLGTDGDLNIDSPTWDDFAARSDDQSWRSGRPRSSGMSISVVSESTQGSESGQDRWEQESGVFPRPRINNKASSTFLGQHYNDDAGTDTSSLSRRVRNQDSSSTLRSHYDRQKSPLAISQQTSESSARDLALRKGYPPITQQEQQFPRSPMLQTDHSDPFHERFSDSLAGEPLDDDKSRKKPARLDLSRLFAKSRELTSGAVSPSASSLKTNGSALPPLSSRRKLNKALSKESLHSQRQSIRSDYTTQSAPLRVEDFPLPKRSESVRTNAKNRETHGTLYQLYDHYEQLPMRSPYMSQIPESRVADGPEIGLRRPHQHPAPMPTPPKSRDSRANQEPQSIPGKEGFSWKNVRNSMASSTASPAYAHSSAASISSRTSKTSRHTSTSMFESNLQQNSVLSLSSDSESDDGTDNSSHISLPVRNPLRNSVAQTQNMPVVQRPRQLSKASDTSKSSQNTKPPSRTASKSPAQRAPTHNKPLAIPELKISEATPTPPRKSSPGTDAERQGSSRQGSSGQRQKPSKKASSIASVTSQPTPPLSPSSIEMQSSSARSSRYMAVTKQEEALLEALRQKRAKMREKIIKEHERVRTPPEAKQERSRSRISEASSASTIRGNSANRPKEEILLYLNTPVSDGRVIEAPEPSPDLSDFLSFGSDDETTPRSSLIYAPSFRGQPRPDSSVSPNPNERVNASFSPLTPPTTVRLSAVGSTTGFPDYRKEQKTKTKNGNSGVRFVDDMNLQQGFSESEHHPELIWGISGHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8A2</accession>
    <name>A0A3D8T8A2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S26 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_00562</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase S26 family. IMP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8A2"/>
    <dbReference type="OrthoDB" id="308440at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.109.10:FF:000015">
        <property type="entry name" value="Mitochondrial inner membrane protease subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052064">
        <property type="entry name" value="Mito_IMP1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383:SF16">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383">
        <property type="entry name" value="PROTEASE FAMILY S26 MITOCHONDRIAL INNER MEMBRANE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S26" evidence="8">
        <location>
            <begin position="28"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S26" evidence="8">
        <location>
            <begin position="121"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="53"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW94799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="181" mass="19913" checksum="6EE783F40DC0B6FE" modified="2019-01-16" version="1">MTFQKYVLGPLRSLQTRYGGHPFRLFIAVGKTCALAHVFTEFGYIINPASGASMLPTFEVLGDHLLISKLHRKGRGVEIGDIVSFDSVAEPGERVIKRVLGLPGDYVLKDTPGSGSSEMIQVPAGHCWVIGDNLPYSRDSRMFGPIPLALIKGKVIAKVLPWDERRWIENDLKPVNVSPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8N4</accession>
    <name>A0A3D8T8N4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_00692</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8N4"/>
    <dbReference type="OrthoDB" id="3445164at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW94929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="28571" checksum="63A19E7FC6A87824" modified="2019-01-16" version="1">MPDYYSDSRSLRDLFCLGGSQTSHKSRRRAKKHSNQEYQAPYSKYQSDMRTSTKSRSYENHTEPPRKAHIKELPLEIQLSIFDHLDPASSACLGLASKQLYPVHRSRHKSVNLFEGKYQPLCMLLQDWAPSDLYLDWELEKMVSREQYDMLEAARSRPGRYHPGSLYTIPQGDTDSYRSKVKRRKHFNNVYETSYYPAYIRPVQPPTSYYDTYQPDHIQPRLKKRQAMGRHDIWTDGSRVRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9R0</accession>
    <name>A0A3D8T9R0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_01053</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9R0"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW95290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="83" mass="8601" checksum="F590997E88DA7B3E" modified="2019-01-16" version="1">MSNQGYYGGQPQQGYPPQGYGQPQPGYPQQAYAPPGQQGYYQQGPPPMQYQQAPPPRNSGGGGGGCLTACLAALCCCCVAEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q3S0</accession>
    <name>A0A3D8Q3S0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PNK3P-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_13242</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000029">
        <property type="protein sequence ID" value="RDW56367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q3S0"/>
    <dbReference type="OrthoDB" id="19045at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046403">
        <property type="term" value="F:polynucleotide 3'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013954">
        <property type="entry name" value="PNK3P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006551">
        <property type="entry name" value="Polynucleotide_phosphatase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01664">
        <property type="entry name" value="DNA-3'-Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083:SF9">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08645">
        <property type="entry name" value="PNK3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW56367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="43801" checksum="ACA17A71F8FB81B2" modified="2019-01-16" version="1">MISWTFIQDTNGTLLKGRHMQHGENTPNSPIIPFSQTPLKIAIFDLDSTLITTANGNLHALSPTDWKWWHPSVPNVLRSTVNCNQELVIVTNQDRLTTADGAEAAESFLFKEKMDAVCHELGIKITIYAACANDRYRKPRMGVWDVMAKDFGFGKGVNVEAYLVGDGAGRKSDHSDSDVHFAENLGIDFSTPEEFFLGEKSKEEVGHKFDPKWYLPADLGGTLNYKPNQAELVILVGLPGAGKTTYYRNFLQPLGYERINEHDIGSLDECFRIAEQFLVSGKSVVVDDINTTSSLRNQWLSLAPKNNVQTYAYNFTAPSDLCLHNDSVRALGGSLMSAECRPIFARIPFRRLQKNVQKPEIDEGIGKVLDVDFEWKGSDDQLETWKKHWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q3S5</accession>
    <name>A0A3D8Q3S5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">YetF C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_13162</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0702 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000026">
        <property type="protein sequence ID" value="RDW56521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q3S5"/>
    <dbReference type="OrthoDB" id="3826282at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.240.20">
        <property type="entry name" value="bsu07140 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007353">
        <property type="entry name" value="DUF421"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023090">
        <property type="entry name" value="UPF0702_alpha/beta_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34582">
        <property type="entry name" value="UPF0702 TRANSMEMBRANE PROTEIN YCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34582:SF6">
        <property type="entry name" value="UPF0702 TRANSMEMBRANE PROTEIN YCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04239">
        <property type="entry name" value="DUF421"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="YetF C-terminal" evidence="9">
        <location>
            <begin position="111"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="202"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="218"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW56521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="243" mass="25869" checksum="7825F57BB8C85534" modified="2019-01-16" version="1">MSSGTSTSSSNGTTIVSGPNVIQQSDFFVKAGVLHPIIVGSIAVIALFGYLRLGSNRSVAPITVFDWVINVALGSTLAGIVNGNSLVRGLLALATMLAFQYTTSTLASRFNERLAWIFQGPPLVVAFRGTMLRTVMTRHRISPSDVNAALRQNGVLNICQVECGIIEPNGKFSIFTTKQLEDAGVDADVLTTVPAYQALCEKESRTGRSRSTDFGNGDEERGEGRSGKEHTSPKVDSAADEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q4P7</accession>
    <name>A0A3D8Q4P7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Reverse transcriptase/retrotransposon-derived protein RNase H-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_12873</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000024">
        <property type="protein sequence ID" value="RDW56806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q4P7"/>
    <dbReference type="OrthoDB" id="5425374at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041577">
        <property type="entry name" value="RT_RNaseH_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34072">
        <property type="entry name" value="ENZYMATIC POLYPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17919">
        <property type="entry name" value="RT_RNaseH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Reverse transcriptase/retrotransposon-derived protein RNase H-like" evidence="2">
        <location>
            <begin position="3"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW56806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="290" mass="33618" checksum="848F1E5549A63897" modified="2019-01-16" version="1">MGQLKAALTIAPALIKMDYSEGAGERICGTDSLGAGWGGFICQVKEGKRHPVRFESGIWNKAERVYDATKLECRAVLKALKKFRFYLDIPGALVTRWLAWIRLFDFEVRHIKGHANKAADGLSRRPPTEQDLREEEQEEDLDKFIDMELDDYIDYEMKALQIMKITVSNPVRIRPLSESQNDRNGDPKPDETGDILHLEDDGILDGRYSRESRDIAWFLTYLTKPRPMAQDEYRSFRRKATNYLVNRKTLFKRGTAGTPQTRVVDLEIERQKIIERLHDYYGHKGRESTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q4V7</accession>
    <name>A0A3D8Q4V7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12942</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000024">
        <property type="protein sequence ID" value="RDW56875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q4V7"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW56875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="84" mass="8939" checksum="B1E0C1C350A4EBFD" modified="2019-01-16" version="1">MSHSQPAAGEGSREPPTPSQHQQATQARMLNMPWFASKIWGLRPRAAVMMTPSWSAIGKQANPGKPSHPEEAPCPSARPPAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q525</accession>
    <name>A0A3D8Q525_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_12980</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000024">
        <property type="protein sequence ID" value="RDW56913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q525"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000023">
        <property type="term" value="P:maltose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF5">
        <property type="entry name" value="ALPHA-GLUCOSIDES PERMEASE MPH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="348"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="448"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="471"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="52"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW56913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="536" mass="59536" checksum="24E14FDB20BA0702" modified="2019-01-16" version="1">MDKTTPTVEIQASRDKHDNQSLFIANAERANAREHEMTLMQAFKIYRKAIFWSALMSTALVMEGFDGKIMGSLYAQPAFQKAYGKPHGSGSYQIPASWQAGLNQGSGIGGIFGLCSAGFISDRFGFRKTVIAGLIMVIGCIFIQFFAKSLVVLLIGQILLGFPLGMFQAVTTVYAVEVTPTCLRAHMTTYVNACWVFGQLIEAGVLRGVLNMSAPWAYRLPFATQWIWPIPLILGIYFAPESPWWLVRQNRPEEAKAALRRLTTRENESDLDLDQTISLITLTIEHEREVENSTTYLACFKGLNLRRTIIVIGCYAAQLLDGNAIRANSTYFFEQAGLATAMSFNMTIVNYALALLGQIVAWFILSRVGRRKVYIWGLSWIMILFIIIGGLGVPLHHKSDSSLSWAVGAVLVISTFVHNCSIGPVAFSLVSELPSSLLRSKTVAIARLSYNILGIPIGIIVPYMISPASWGWGAMAGFFWAGSCLLMLTFTFFYIPEPKNRTLTELDILFEKKISARKFATTQVAFEEILDRKSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q5H8</accession>
    <name>A0A3D8Q5H8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein-19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_13004</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000024">
        <property type="protein sequence ID" value="RDW56937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q5H8"/>
    <dbReference type="OrthoDB" id="10254221at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004074">
        <property type="term" value="F:biliverdin reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017743156" evidence="2">
        <location>
            <begin position="24"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="NAD(P)-binding" evidence="3">
        <location>
            <begin position="11"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW56937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="228" mass="24106" checksum="FB7A6D60DC707582" modified="2019-01-16" version="1">MAAKHHILLLGGTGICGLLFAQAALHDGHTLTLYARTPSKVPAAMAANPNLHIIKGDLGDAEGLKAAAACGADTFVSVAGPTLGKRGGTPITNALKILYPLLLANGTTKRVMVLSTASYSAPQDTASLKWFVAIQCYIKVIGGDTYEEISGFTKETVALGSAIEWTVFRVPLLKGEELGAGGEVNTAWVGDKRGKDGLHLDRGRLVRWVLKEMDEKKWVGLCPLLSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q746</accession>
    <name>A0A3D8Q746_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_12684</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q746"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="459"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="74"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW57234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="591" mass="66412" checksum="0B7AE9D763302B45" modified="2019-01-16" version="1">MASTAIVANDLSGHARLYAGNVHEENHNIQYALISFPGARPQSPKERCRYELVLTVPGEDRGRIITAKGTPAKGTCEWIEKVQPFKDWLQGQIQFLWVFGGPGKGKTFLSIHIVKHLVSMKRRLNLNTPTEPLVLEYYCDNSDSQRNTALCVLRGLLCQLLDADDSLYDLILPDFNALDQGRHGLFSEMHIEKLWRIFLKMLEKLQRQAYLVLDGLDECDDKSIRFIRTKLQELHEVSGTEAGNVSTILISRRTLDEDIRVAQPIDLDTAHINERENDVKVFISDSIAQLRLGLDHRSRLEGIFQARAEGTYLWVSLALSVLKIPDNVQRILESDSAIDELLPAGLDKIYARILLTIPEGERELSAKIIQCLSVAYRSLSEPEITELTGASEFQVHMQIERRANLLTRPTNGRIQLIHLSLKEYLQQAPSIGTLESTPGMKTSLLHLVSFVLDKQLLCVLLGSFLFSVGLAFSVVLLRRGPVSHILSIFFTVVAVTLSGVGKSSIAVNLLLGYQKRLTISFFAFQKQEVHQQLLETILKLMKAHFHNESRYIPKPGKLAAEILYSMDASSGSSIFWTVIPSSFTMALFIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q7D1</accession>
    <name>A0A3D8Q7D1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_12524</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q7D1"/>
    <dbReference type="OrthoDB" id="3543260at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF138">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="142"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="212"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="400"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="514"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="769"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="808"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="845"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW57723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1163" mass="128606" checksum="00F091CB08B6E412" modified="2019-01-16" version="1">MAPAVLFHLTRCTMNIMVGSEGLTMSLIASRSIDRMAAYFNKVIPEVYTDDNVQRSAILVNGSHSERQTELLKLLVYLASNNLILDDRSYFENERKFMKDAEAFAAVMTDAISIVSTLLTADPRIDPDRQAAVFHWRSGRGEPIPSLHYALYRGSLDITRVLVQAGADIHRVDYGGWPPLAIAAMRFPHRQSFQMAQFLLDSGANPNDHVRSGPSIVHLALVAANIELVELLLCSGADVTQRCPGLRAYFALWPPTLVVSSIFYDLWPGLESIGCYDFAASAGVFEYSSGSVHLKLGYDAESVVIHFIGLLKKSHFGLHTLQQSGASVMIIPAARGHTEVLSYLRAEIGQCVHSINGGFSPIYAAVVGNQVKTCEQLLLWGASAQIDIDLRDVRKDVLPTPLHFAVGNGSNELCRLLINYEADFNQLSTVSLREYEHEPSDYFEVYPRRGITYTRLSPVRLATLLHHWKIASDLVELGATATGDDLAEAVKYGQMQLVEQLLRQQIHPDSAVQQGVTALEAAISNGHISITTQLLHAGATVKSIPVASIFILQDVSTIKSLLQSLPISWECGKGRSYLENAILGGNKDVLALALSLNLSEYDSGALCAAVSQESQDPSTANKAILINLSLEATAVSIAAYYGRFDITDKLLSSHGQRIRGNLAVMPEKEFWYTRDSSSEVPVLAEAESHLLQEKMEKWNGWYTSPYRGIPPLFLPVKRKNESMIEALLDYGYKVDGLTLKAAICYKLPNSLLEKLIEKCDDVDGKCLGEFSTPLQVAARYGNRALVEKLLASGADLHTSRHLGGSHIDGYTALISAVRAGHIDLVCLLLQRGADVNQRVETEYDGAYTALQVAVSIGYIGIAKQLLDYGANINSRRAPYLTFPGQGTTLEQASYEGRLDIVQLLLDRGVCTEGYDRVQYVQAFLIAEKSGHGAVAQLLRNHRAWSVEDENIRAELDEYEIQLESFFIHPKEFCEAELVEVVRKSRESHSFPHRWWKGGPSTQSILNAIFNAEGISEDTDDSMTDSDDSLTDSDDGAVELESHSHDAILVDSTLPAHVISDDHEALEPCGSNWEGAHRLQEELSAEWLMSSSFEPELKGETVFDEEQACTQGFPQTKDYYSTETSAWERSLVASQDDDDDRRKEILADMMGEKEAPFREVEWML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q859</accession>
    <name>A0A3D8Q859_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_12619</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q859"/>
    <dbReference type="OrthoDB" id="3555540at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW57818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="393" mass="43363" checksum="CB5FDAD499DA297B" modified="2019-01-16" version="1">MPSQSPAPPPTAKQPSTPTPRTCTAQAPWRHMRWPSQFTVAAVCAGALAIFLVIMAIVARFPSPIARNCFGGLSLALYVIPLVLGVQMMIAETRSWLSKKEITKTANLRNTVLTVNITIPLMVGAYIWMWYPGQRQFKEFVNRDTVSAMKFPAVAVFQRLDFTGQANLLGTGSKCFLGWYIYSGPNCSSLTANEMTMESKCDCKEDWSTNIPEGFVWYNTSFRYLLFQPTEDLISPQPTYLMMLQVFFNYNLTQATIDSGFGPQPSLSIAVFDPDLTLEEAMRNGYTSLVDINANAATSINLDIVRRQNTPGADANYDYSNLVISSVPALDLVCNTATEGSWPCVTIIKARHKETASWEMCTDFGIATFPDLSADEYHANEGYGMDGLAVASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q9E8</accession>
    <name>A0A3D8Q9E8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12402</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q9E8"/>
    <dbReference type="OrthoDB" id="10262413at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05262">
        <property type="entry name" value="SDR_a7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF9">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW58472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="302" mass="31136" checksum="3E74EF34D941402A" modified="2019-01-16" version="1">MRVFVTGATGGIGSALVKELLHAGHTVLGLTRSDAGADKLQAAGAEPLHGTLADLDLLAKAAAECDAVAHLAFNHNFDDYMGACATDRAAISAMGSSLAAAGGNKALIITSGTMSCDKGRTVTEDDGIDMTNPFGASRGRSEALALGFGDQGVRALVMRLPPVVHGDGNVGFVGLLLRAAGTTKSISYVGGGENRWCTVHYLDAVCAYRLALETGKSGSVFHGVGEEGVVVKDVAEAMGKKLNMPVVSKTLEEAQQVFGMMSAAIMSDNPASSAKTREALQWTPVHKGLIEDLAGDMLAKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QBK7</accession>
    <name>A0A3D8QBK7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative MFS multidrug transporter-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_12157</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QBK7"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF135">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="325"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="56"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW59233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="495" mass="53601" checksum="DC48552F8C4D4E5C" modified="2019-01-16" version="1">MSKIDNSQAEKSSNDGSLESGSPDNHSLADTNIVDWDGKDDPANPINWPSRKRWAHAIMVALFALVTNMGPTMCAPGINEIIADFHISSRSLSTLAITIYILGLAVGPMFMAPLSEMYGRLPIYHLSSVVFVAFIVGNALSKNIAQFMVFRFLSGCAGGTPMALGGGTIADVTRLEKRGAAMALFSLGPLTGPVLGPVMGGFIAANKGWRWSFWVLAIFGAAVGIGALIFMRETHPKILLERKAAALRTSTGNPNLKSKLAHTLTPRQVLVQALGRPTILLLRSPVLLVISLYVSLVFGLMYLLFTTFPDVFEGQYGFNTSTSGLVYLGLGVALIIAMFAFGALSDRIQAARMKADGVQRPQPEYRLVLMIWFSPFVGVGLFIYGWTTHYKVHWIVPIIGTAIIGFGAFFVLMPAQLYLVDLFGSEAAASALGANNLLRYLSSTFLPLAGPRMYKALGYGWGNSLLGFLALAFVPAPVLFYKYGERLRARTVVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QEM9</accession>
    <name>A0A3D8QEM9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_11912</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QEM9"/>
    <dbReference type="OrthoDB" id="4841197at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021054">
        <property type="entry name" value="Cell_wall_mannoprotein_1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12296">
        <property type="entry name" value="HsbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW60306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="169" mass="18772" checksum="890CC61DC1EEAAF0" modified="2019-01-16" version="1">MDKVFKHLGDIERKAEKIDKISSKGASSLGMKEMLKLSSKGQSISSCMKKTVKDYQNVTPTEAEAQKVIEIVTKITTLNEHQMKTVRDDKPAMEKMHVGGLVKKNMVKSEETSKAFWATLTEKTPEGPLKEEIKALAARVQKAYTETYQLYANATGGEDQDVDAVDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QEW8</accession>
    <name>A0A3D8QEW8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Polysaccharide export protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_11806</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QEW8"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021047">
        <property type="entry name" value="Mannosyltransferase_CMT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34144:SF7">
        <property type="entry name" value="EXPORT PROTEIN (CAP59), PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05020)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11735">
        <property type="entry name" value="CAP59_mtransfer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW60200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="450" mass="50855" checksum="86B0967230F91F4A" modified="2019-01-16" version="1">MFFSRYQRRRITRPLLLLSTLLFLLDILHLTTKVSRSLSTQPPIAPEQKILIASIFRNNGRILHSHWIPSVISLIQTLGPQNVYVSIIESGSQDDTKVVLASLQTQLEALGVQHKIELGETVYEQLESVSHVPEEGKREGWIFTGRGKDRTESGWELRRIPYLARLRNKALEPLTGGKLERDGFKVQKVLWINDVVFSTKDILALLTTRSGHYAAACSLDFAHAGSTSYYDTFALRDFSGSKTSSPKFPYFNSPSSLSALLNHSPIPVKSCWNGAVVFDAAPFHSSFVAGQGWKIKNGLRFRGVDDVLAREHVEGSECCLIHADNPLSEEVGKGVWINPAVRLAYNEAAYISANPGTVFSDSETEGVRKIMRVDEGVRELWPGWFEVVVGTYVNRVRRWVVWLTQWSERKTVERRVARWENAVKGRQERGTFCLVNEMQVLFENGWQHVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QEX9</accession>
    <name>A0A3D8QEX9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rhamnogalacturonase A/B/Epimerase-like pectate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_11816</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QEX9"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000023">
        <property type="entry name" value="Exo-beta-1,3-glucanase Exg0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000026">
        <property type="entry name" value="Exo-beta-1,3-glucanase Exg0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017732010" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="2">
        <location>
            <begin position="91"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="2">
        <location>
            <begin position="442"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW60210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="814" mass="85685" checksum="4B08C4B4FEDEBA10" modified="2019-01-16" version="1">MKLAHSFTLACLALSVNSEKLAISEVETVVGKVIDRLGDYVKYHGNDSVAGSISSQDDMASVLPRQATPYWYEEIAHQGISAFGPSGYTVYRNVKDYGAVGNGIADDTAAINAAISAGGRCGQGCSSSTTTPAVVYFPAGTYLISSSIVDYYYTQLIGNPSSPPVLKATSSFSGFGLIDGDPYYTENLNWGSTNVFFRQVRNFVFDLTNIPATTQSTGIHWPTAQATSLQNIVFEMSAASGTQHTGLFVESGSGGLMTDLTFNGGIYGASIGNQQFTMRNLVFNNCVTAISQLWSWGWLYQGISINNCQTGIDVSAGGSSALNVGSIMLIDSSITNTPVGIITAHTSTSSPATAGSLMLENVVLTNVPTAIQLTGGSTVLAGTTGTTTIAAWGDGHEYIPNGPNSFEGPFAANTRPAALLSGSNYYTRSKPQYETLPSSSFKSVRSGGATGDGVTDDTSALQAVIDAATAAGQVTFFDAGTYKVTRTLFIPAGAKLVGETYSIIMSSGSFFNNMDSPQAVVRVGHVGDSGQVEWSDMIVSTQGAQAGAILIEWNLATSGTPSGMWDVHTRIGGFAGSDLQVAQCPTTPGSSNINTACIGSYMSMHITTSATGLYMENCWLWSADHDIDSSSNTQITVYSGRGLFIESTAGTFWLVGTGAEHHTLYQYQLVNTQNIFMGFVQTETPYYQPNPSAPAPFTVSSSLNDPDFATSCAGQSGNCANAWGLRIVNSQNILVYGAGLYSFFDNYSTTCSNGGGPENCQTNIFSLEGSNSNVNAYCLSTVGTTNMITENGATLAVYADNVSVYPDTIALFRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QF52</accession>
    <name>A0A3D8QF52_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7703 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_11876</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QF52"/>
    <dbReference type="OrthoDB" id="405906at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056120">
        <property type="entry name" value="DUF7703"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37013">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_1G05950)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24802">
        <property type="entry name" value="DUF7703"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7703" evidence="3">
        <location>
            <begin position="34"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW60270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="407" mass="45310" checksum="C5CC77AA39933913" modified="2019-01-16" version="1">MSHTVNVTVPYVELADFDWSFTRTGPLPWNQTVWSLLAVFTALPIWMTIELAVWVFYTFKRYSGLYFWSILVCTFGTSIRAVGFILKDCVPECNWVISTTIAEVGWASMVTGFSLVLYSRLHLIPSLRASQFTLRIILAIIITDALILHIPTIVFQYGISNSNAAIHDKFLPFMVPMEKVQVLGFSVQETAISAIYIYATVNLLRGSFNQKIRRTTIFLIIIQVVVILVDVVVIALDYCEYYTLKAVVHSFIYALKLQLEFVILNQFRHVIAKGGLAPRGLDALELNNDSNSPTPLSEPSTPKTGLWASSNALSCEKTTAASEGHRTNSQSSTQYNSDDDISRVSPNSAQPYMTTESPLSPTPSSIRSSATLREDSGRTALKPAPVRQSSGKANALDLERQYLGTWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QF76</accession>
    <name>A0A3D8QF76_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Dyp-type peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_11914</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DyP-type peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QF76"/>
    <dbReference type="OrthoDB" id="76259at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048328">
        <property type="entry name" value="Dyp_perox_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048327">
        <property type="entry name" value="Dyp_perox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006314">
        <property type="entry name" value="Dyp_peroxidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01413">
        <property type="entry name" value="Dyp_perox_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30521">
        <property type="entry name" value="DEFERROCHELATASE/PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30521:SF0">
        <property type="entry name" value="DYP-TYPE PEROXIDASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20628">
        <property type="entry name" value="Dyp_perox_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04261">
        <property type="entry name" value="Dyp_perox_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51404">
        <property type="entry name" value="DYP_PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dyp-type peroxidase N-terminal" evidence="7">
        <location>
            <begin position="91"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Dyp-type peroxidase C-terminal" evidence="8">
        <location>
            <begin position="222"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW60308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="43644" checksum="A8DBBE1A082D2BF1" modified="2019-01-16" version="1">MSISKFRTTIGFRFYDGLRDKSLPLFRTIDRGQTLVRATLAQELRRNLSGHPTLPFDRPPRRPSVSRLQVAKLATQSSMSRRVPIEPQRVDAPLTQSATFLVLTITDSPKAVKAIRSTLAGLDGLAKNVAIRDLNASFACTVGIGSKAWDLITKLPRPAELHPFPEVKGEVHTAVSTPGDLLFHIRAERRDLCFEFERQLMSLLDDSVKVVDETVGFRYFDVRDLLGFVDGTANPVGPAVPASILVAEEDSSAVGGSYIVIQKYVHNLKAWNTLKAEQQEAIIGRTKIDNMELDDADPGQQQSHKSLATIEDEDGVEHDILRDNMPFGSASSGEFGTYFIGYSRRLWVIEKMLQRMFVGEPRGLHDRILDFSTPLTGTTFFAPSASLLASLDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QHM8</accession>
    <name>A0A3D8QHM8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_11245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QHM8"/>
    <dbReference type="OrthoDB" id="3540452at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW61353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="301" mass="33686" checksum="1D9BB27F51297EA4" modified="2019-01-16" version="1">MFGLDGDPQLRRQVLMALKRSPASAIIVDGRCIYRGGETNLTSNSARAVARTRDERSLSPSRPRAKRSRSPPEIPRHQEYSEYRDRSPQRGYDEYRTRSPVGRHTARPTSRDRYRYTRSRSASAATHRGRPDSCSPLPEPRHLEHRWASLRHASGSNAVTIATPKISSTQPSQDLMPPILSMAQLETLSVKPQSVSKLVADPKKDVTKSSFDRVKLGDMTNVARPSPQPREVLVDDPHFVLGVGRGATEAEILDTFNQRIAEVETERLADTGFVLYTPGTESIYEESIRMLKAAKSQLLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QI91</accession>
    <name>A0A3D8QI91_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">OPT-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_11445</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QI91"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="294"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="399"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="463"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="533"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="604"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="708"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="735"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="765"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="813"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="853"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="886"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="914"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="936"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="964"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="109"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="652"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="27"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="658"/>
            <end position="673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW61553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1028" mass="113787" checksum="90F7813A2B659119" modified="2019-01-16" version="1">MSRPPQPSSTSAPIPCHDHESNSTDIPLSSLPSSTRRRASSSLSDLDPESDAALLRRHRRDSSDSEHEIIDGSIALNRTSANPLRSLFGLMSKAPLFLRSAPGFGTGSYGAVPVGAPNESSEDEDNEGRKRSTGRRVAGSRLRNAVSSASIKPRKASARRSSDKASYSSGRRRSSNFTHSRGRAGDNLDVDAGLDSRYAAVGIPIGSDESQTDKIHFKIPDEDSEEAILDDASTTTEDEDPPDNSPYAQVRASVAATDNTTLSINTPRMWTLSLLFAILGSSANLFFSLRYPSVAITPVIALLLVHPLGIIWDALLKRGDDPEEEFVDGVLVGRTPPDNASVAPRGGLLRQIRLWLAQGRWNEKEHSCVYISSNVSFGFAFATDVIVEQTHFYNQKVSITYQLLLILSTQILGYTFAGLARRFLVRPGGMIWPGTLMSAAMFTTLHKEENTIANGWRITRWRFFLIVWLSAFLFYFLPGLLMPALSYFSIITWFAPKNVVIANLFGVASGLGLFPITFDWAQIAYIGSPLLTPFWAAMNVVGGLVIVMWIIAPIAYYSNIFYSSYMPILSSAVFDNTGNLYDVSKILTPDFLFDREAYQNYSRVYLPITYVLSYGLQFAALASLLTHTACWHGKDILRQWQRSLQEVEGQTKGAYNSLPGSNTSSSGGYPSANTGSLRLQRSTSNMDNIISEEDVHNRLMKRYKDAPISWYLATFVTMTAVGMFVVEYYPIHLPWYGLLLALGICTILFIPIGIVMAITNQHSSIYLICQLVCGAVFPGRPVANMVFVTYGYISSAQGIKFSADLKLGHYMKIPPRILFTVQMVATIVSSVTQIAVLNWMFANVPNICTPQAINGFVCPIARVHFNGSILWGVVGPKEFFGPNATYHPLVWCFLIGAIAPVPLWLYSRHKKTSIVRKINLPVLFGSLSWIPPATGINFSVWALVCYIFNYVIKRRAGAWWGKYAMTMSAALDSGLAFGLVVVFFGFVYPGWMDNFKWWGTEVYKQGCDWQACAYKTVPEGGKFGPDKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QM31</accession>
    <name>A0A3D8QM31_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Enoyl-CoA hydratase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_11012</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QM31"/>
    <dbReference type="OrthoDB" id="14970at2759"/>
    <dbReference type="UniPathway" id="UPA00659"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051750">
        <property type="term" value="F:delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.12.10:FF:000004">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000024">
        <property type="entry name" value="Delta3,5-delta2,4-dienoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045002">
        <property type="entry name" value="Ech1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149:SF1">
        <property type="entry name" value="DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW62710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="281" mass="30328" checksum="6F593C7AB07B7E86" modified="2019-01-16" version="1">MAARPTYKYFLVSTPAPFVAHVQINRPDKLNAFFEAMWLEMKTVFDTLSYSPEVRAIVLSGVGDRAFTAGLDVQAASQSGILAKQAESMDVARKAQGIKRHVEEFQACIASVEKCEKPVICVLHGFSLGLALDIATCADVRFCSSDVKLAVKEVDIGLAADIGTLTRLPKIVGSFSWVKDVALSARVFGAEEAFRVGLVSQVLESKEKAVDAATKYASLLASKSPVAVQGTKELLNHARDHTVSDSLRYTGVWNSAGIQTDDITKAMLSGLKKTKPTFAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QM33</accession>
    <name>A0A3D8QM33_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_11157</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QM33"/>
    <dbReference type="OrthoDB" id="273452at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000223">
        <property type="entry name" value="Lipase/serine esterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF65">
        <property type="entry name" value="ESTERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="269"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="5">
        <location>
            <begin position="8"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="346"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="362"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW62855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="444" mass="49768" checksum="FA8D22839D91389F" modified="2019-01-16" version="1">MDYTGGSQEAQHLCVLVHGLWGNPNNLAVMAKSLRAKHPEDTLHILVAKRNSGSFTYDGIELGGERVCQEIEEEIEKLAKLGQEIKRLSIVGYSLGGLVARYAVGLLDSKGFFEKIKPMNFTTFATPHLGVRTPLRGWHNHVWNVLGARTLSTSGRQLFTIDKFRGTGRPLLEILADPESIFIKGLAKFERRTLYTNIINDRSAVYYTTGISKTDPFTNLDNIKINYLKGYDDVIIDPACPIAPSDPEESDTTFSARFIRSSQTTIGRLPLILAMVIFIPIGVVAFLINSGVQSLRSNRRIRLYERGLAGIEPGNYRVPLLLTGMREAVEDAYENLNSAQSNEYLVEGTEEEEANDEPSSPRSERPQTPKTTEKSSHPDVPTLALASYQFSMIQALDNVGWRKYPVHIHKARHSHAAIIVRSEKPSFDEGKVVFRHWLDEEFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QM40</accession>
    <name>A0A3D8QM40_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_11164</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QM40"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW62862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="132" mass="14967" checksum="22685D4C8085A418" modified="2019-01-16" version="1">MALDFSEMDIYDTNESLFYDRLTHESLNAPYKIRDSADNGWLDAYCAVCPVPIALFDPFHRDEDQERAGYNPTLVIEQELARVSRVPVVEYNPDGFQASKYGHLVELDIDVNDAAEIALDVSLLDSVMTLMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QM69</accession>
    <name>A0A3D8QM69_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytochrome c domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_10856</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QM69"/>
    <dbReference type="OrthoDB" id="10291693at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009056">
        <property type="entry name" value="Cyt_c-like_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51007">
        <property type="entry name" value="CYTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="2 3" id="KW-0408">Iron</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome c" evidence="5">
        <location>
            <begin position="75"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="125"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="619"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="662"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW62554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="683" mass="74619" checksum="2B8CABB19AF4E9F9" modified="2019-01-16" version="1">MAPKSLRKLPGTLSKSVGKKAKAVRQSVIGLFGGKDSGDTESLVPVPRVPLPPAPDHGILVNGSNRTVYQTGLPSNATAGVDENIPPMPECNACHDAANLAYANNAAPDSVEGLAPVLPNITGVNSSEHTGSASISRDHHASHGTNAADMPDGQSGPNTRLASDATAVDNDDQIKPAPAQEPSANTDARFSDMDASAHESYKQDYPCKSGHPVYMADTLTFYYFWECLRWYHQDPNHGMVGTEHKVFSSVELMQNLELGKDRLPFSDEQIDLALRREEKSFLYRHDHGSWLTQRRCDLLNYINRLTIVDGALSFPSVQGDSNYEVIDCDYFGDIGKFLSKIPKNGGPFIGLHDPRRSPDGRSGINPFRRRLQHCILPAFRSERKLTTPTWHFEHNKAKPLAHSHQKADFAVYCFRDSDPETYLHGNSGRPKSTDRFRVVAAVFGGGEGHSATVRGENQFNAGLPPTFTIEAAIPRHIYDANIITKRPTLSWKPWTPSVLDAMLALKEASLQYNASGQAFNLDTVGKFSGLENGDSGFPGNFTMKEVTYALNYQQRGNDIEKLFHDHQTDCTGFQLLRSRMRPIVTAAGQVMAGIDEQQAKQSTELLTAQHLQVQQKQLREAAANGQDDSAGVVGTAMNMPPASTGAQTQPPAGDKNDEVDLGARSGRLRNLLSRSGKRASSAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQI8</accession>
    <name>A0A3D8QQI8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_10412</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW63910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQI8"/>
    <dbReference type="OrthoDB" id="5344169at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11392">
        <property type="entry name" value="bHLH_ScPHO4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="3">
        <location>
            <begin position="582"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="81"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="246"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="432"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="608"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="647"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="246"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="337"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="613"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="635"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW63910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="679" mass="72989" checksum="BFA8E3E100074547" modified="2019-01-16" version="1">MMDSSAVWNGQDPTLSIPSQDDFQQFLDIGNLNFDFQDFNQQQGNGSILHSNSGEVMGMRMDNSNRGGIAQQDTIMQDHVPMTSASSHASIPSTPIAHGHPMGDSISDLDAQIQFLQQQKHHQQQRQLQDQQQRRYFGQQRSIPPTPNSVEMHGSNGHPQFFSQSDSQQQAMYESYQMQAKEQEVRPHGGLDDNLVLTFREQMAFTPLVSPAVTPLEAHFNIPEYTVPGAYFSPLSSPALHAQNEHSSVYDQVHSGTTNSPIDMNLDSHSAPTSSVALSKKPSRKALQKPRSSRPSVRQSPIVKPKRRKPGSTAGISSQALGDIIEPSNASPNNANTARSLTASRENSESESISPEHLSDMAPPPIPRQGSIGKSPYMAAQKENGEMQQFSLGAPATPASLMRITKSPSVNHASANQDIDLDDQAMEGFALPEPAAEPGRPPLPRIDTAPDGQMTPTLGPTSVRTPGLHPLPSPAFARPKSAASSSQSPQIEAMNGGPFRKTPLLAARGTKKRGSVSSVHVSPALRPRISPSIKPLLPGGGSVSNDTASLLLASKSNYQNILEGTHLPGVSYPTELSTNLTSKRTSHKIAEQGRRNRINSALQEIATLLPRGNNKDSGGEKSADGVDGADGESKGTGQSASSKASTVEQAIEYIKQLQNEVAAANKRAEEAERKLETKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQW2</accession>
    <name>A0A3D8QQW2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Meiotic nuclear division protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_10603</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the MND1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQW2"/>
    <dbReference type="OrthoDB" id="9978204at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005647">
        <property type="entry name" value="Mnd1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040453">
        <property type="entry name" value="Mnd1_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03962">
        <property type="entry name" value="Mnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF026991">
        <property type="entry name" value="Mnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mnd1 HTH" evidence="7">
        <location>
            <begin position="4"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="116"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR026991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW64101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="210" mass="24006" checksum="69478E859E68C204" modified="2019-01-16" version="1">MARLVEWFRDTAGVYNIKELEKAFTTVAGVNSMQTKDYIQNLVDENHIRCERIGSGNWYWAFASDAKKSKDNVINNLKNEEQTLSTSIGETQAQLDQETALRRGEDEALEAQGTSRDKLLQHHEALTKEHEALDKELATYHDNDPEIYNRKVEEVKRFKSIAEQWTANIDNLETLLLRLANNDRDAVAGLMSRACGDEYIIGEGFRELNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQZ6</accession>
    <name>A0A3D8QQZ6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mitochondrial inner membrane protease subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_10717</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S26 family. IMP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQZ6"/>
    <dbReference type="OrthoDB" id="9996127at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037730">
        <property type="entry name" value="IMP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46041:SF2">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Peptidase S26" evidence="12">
        <location>
            <begin position="32"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S26" evidence="12">
        <location>
            <begin position="125"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="54"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW64215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="190" mass="21781" checksum="B452A0B8D509AAF3" modified="2019-01-16" version="1">MAFPRLASIFSRGSRYRPFLRDFSLTLFGIATWVPVCIFINQHVGELTFINGASMYPYLNTGYNNSTRKDIGYTSKWNSFHNLERGMIVTFWSPDHPEVLAVKRVIALPGDKVYTRAPYPYPTAIVPSGHVWVEGDNRDREASKDSNYYGPISMSLITGKVTHVLYPWSSFGSVKWWEFKGKTRVIKARE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QR26</accession>
    <name>A0A3D8QR26_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_10765</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnitine/choline acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000019">
        <property type="entry name" value="Polyketide synthase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000002">
        <property type="entry name" value="Probable polyketide synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.70">
        <property type="entry name" value="Choline/Carnitine o-acyltransferase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.250">
        <property type="entry name" value="Malonyl-CoA ACP transacylase, ACP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000542">
        <property type="entry name" value="Carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039551">
        <property type="entry name" value="Cho/carn_acyl_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042231">
        <property type="entry name" value="Cho/carn_acyl_trans_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF22">
        <property type="entry name" value="SYNTHASE, PUTATIVE (JCVI)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00755">
        <property type="entry name" value="Carn_acyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00440">
        <property type="entry name" value="ACYLTRANSF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="11">
        <location>
            <begin position="4"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="12">
        <location>
            <begin position="932"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="10">
        <location>
            <begin position="2145"/>
            <end position="2223"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="8">
        <location>
            <begin position="932"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="8">
        <location>
            <begin position="1102"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1273"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1276"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="8">
        <location>
            <position position="964"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="8">
        <location>
            <position position="1167"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="2560"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600542-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW64263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="2839" mass="312991" checksum="2661EC2E743087A5" modified="2019-01-16" version="1">MASPVPIAVIGMGCRLPGGANGPEKLWDMLAEGRSGWSEVPSDRWNWKSFYNPNPEAKESVNSKSGYFLQQDIASFDARFFNIPVWEAHAMDPQQRILLETTYEALENAGISLQSIRGSDTAVYVGMYARDYDRMGYKDLPQITKIHITGTGEAVVSNRISYLFDLRGASLTVDTGCSGSMVALHQACQALRTRETGMAIVGGTQLLLHPDQSIPMSMVGMVNPNGRCFVFDSRGSGYARGEGVGTVVLKRLDDALEAGDPIHAVIRNSALNQDGKTAGISLPNADAQAALMRLVYANAGLDPRDTTYVEAHGTGTQAGDNAEISSISSVFTNSPRDTDLYVGSIKSNIGHLEASSGVAGLIKAIMILKKGAIPPNIDFIKPKDTLKLEERNIKIPLSLTPLPQGGSVPSRVSLNSFGYGGTNAHVILESAPAAGTQKAVQNGSVAPNGERNGISKAVKSGPVPRLVVLTAASEDSLRSTIKSLHQWVTSANPKSFSIEDLAYTLSLRRSILPWRYSVVASSQEELASALDQPNPRICRAAATVLITFIFTGQGAQWYAMGRELVTEESNFRKSIQASDRILADLGCQWSLLEELLKDEKDSKLGESELSQPTTTAIQLALVDLFASFGIRPQSVCGHSSGEIAAAYTAGALSHREAIEAAYRRGLWSAAAKKLNKVKGAMLAVGIGEKEVLPYVKKVKAGVITIACVNSPSSTTISGDEAGIDELKEILDELSVFNRKLKVDSAYHSHHMQTVAKQYQQSIENIKAKVSQPDIQFYSSVTGTKKNSDFSAAYWTQNLVSKVKFSTAVQLLAKDMKGSRQSSNVFVEIGPHGALAGPLRQTLATISSQNFKYVYASALTRGQNALKTVLEASGQLFDNGYPVDLEAIMSMMGSEDHRRIVTDLSPYSWDHSAKFWHESRLSREHRMREFPYHDLLGLLDVNSNIHEPRWRYHINVDTIPWLKDHVIEGDIIFPGSGYICMAIEAMKQITQIRKVPGTVSKVILRDINFLKPIIVPEPSMDGFTPEIEVQLVLSRSKGENSRWESFRIFSLSGGKDGHWSEHCSGRITVEMASKLDEVEGNREEDYKTTEDLKRLQTLAASSTTNVKPQQFYDELKQSGNDFGPAFAAMTEIKYGNQQSISRLDIPNIASVMPFAFMQPHIIHPTTLDAINQLVAALFKRHCSNSPLMPVYMGEISLKTSITNSAGEELVVASDIYPEGNRSATGNCWAFQKDTDGNLVPVFSTIGLRIRGIGDSTSSESVPFQRKMSYRISWQPAHPNTSDMTVDPASENNQPTESISETEKEKVNGDLPAHSSEPLMKAFPKVQFVSVSNNAAIEALYDKLLQSFEKQGILCTRTTWDKVETDSKTVYIVLDHLDCPVLSSPSPERWAILKNFFLKSSSVLWASIRGKDSTAAFKGLITGVARVVRRENEGLKLVTVDVNEETLDSLGDITEALWEIAEASFWPVLEPEASNELEYSFQNNILLVPRLQVDDKFNTWVDRAVKTSDLEMALYQQANRPLMLEVETPGLLNSLRFVDDLAALVPLAAHEVEIEATAYGVNFKDVFIALGQMLPGVNMVGEVAGFVKAVGADFQDRFKVGDRVAAVGARPFASHARVSGFQACVLPDSMSFTVGASIPTVFLTAYQCIFEVARLRKNQTILIHAASGGVGQAAIMFAQHIGAEIFATVGSATKRQLLIDRYGIPASHIFSTRSRTFKDGVLRLTNSKGVDVVLNSLSGEWLSDSWECIARLGTFVEIGKADIYQKNQLSMVPFDKSVTFASVDLVVLFEAQPEEMSERFSKVLAMFESGILSKLEPITAFPMSDIESAFRLISSRKHTGKVVLEVEENTMVKAVPSRQAPLQLEENGSYVVAGGLGDLGKRICRLLASHGAKSIVTLSRRTLDAEAQELFANELEELGAAVHMLQCDIVNESDVQDVILKCKKLPPIRGVIHAGMVLKDHPLEQMTIDDYITGTQPKVNGTINLNNAFQSEALDFFITLSSVSCILGKTGQLNYSAGNAFQDAFAHANTHKSHTQYISLNLGAVDGSDAITSLPVRQRELMRQGAILMKFEELFKVLEYSMGPDARKDELVQSVLGFDRDSMEAAGDTFALNNPMFSQLPQSTKDVGKGDNKVDIEDAVRKAKTSDEASIIITKAIIEKFSLFLNRSIEDLDPDQPPSSFGLDSLVSIELKNWMVRTFKATLQTAEIGDAASLVALARTVTSRSKLVNDDLQGPNESDEAPPVALPDDTVDEIEEVSEYRCCRFAKTFPKYPIMDLDKALRDLLEDVRPFATPEELVEVHKNIIEFKAPGSVARQTYQQLAERASDPDIDNWLFDLQIDGVWLKRRFPLAPFQNFLATHHNSKIPHQQAERAALIATTAFKFKQAVESDVLEPHWYFGVPSCMDTWQWLFNATREPGKGQDKMRKFPGNDYCVVLRRGHVFKVDLKEGEENLSFHRAKTIFEAILDQVEDEGSWAGILTSDERDSWAAIRGTLESAGPANAEYFSIIDRAAFLICLDDGSPTNGPERVRQYYLGDGFNRWHDKCLQFMVCSNGVSGYTVEHTMIDGLTVHELNDWIHKVIAEHKPEEFATNGHRNGHGSAPILEEYVLTTTPDIDNHMDVLREKYLSYTSKREFANYELKSFGNTLLAEHNCPIKATFDLTIQLASRIYFGYTPASWEPVSMAQFHKGRFAIVQVITQSVMQFCFSAADNTIPAPDRRNMLLTAASDYNARLRDTYGGNAYFRLMNAMKTVWPEHEPLAPLFSNPTWLKTHPRLIMSNLTDGGSLDSAYVMGDSESIWISYSVLENEARFSIVGPAGDLKRFLSSLDQAGEVVKGLVLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QR58</accession>
    <name>A0A3D8QR58_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-polygalacturonase</fullName>
            <ecNumber evidence="3">3.2.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BP5796_10632</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(1,4-alpha-D-galacturonosyl)n+m + H2O = (1,4-alpha-D-galacturonosyl)n + (1,4-alpha-D-galacturonosyl)m.</text>
            <dbReference type="EC" id="3.2.1.15"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.15" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QR58"/>
    <dbReference type="OrthoDB" id="1546079at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000002">
        <property type="entry name" value="Endopolygalacturonase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050434">
        <property type="entry name" value="Glycosyl_hydrlase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884:SF1">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017609135" description="endo-polygalacturonase" evidence="14">
        <location>
            <begin position="21"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDW64130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="376" mass="37553" checksum="384CBC3F5EC782D1" modified="2019-01-16" version="1">MVSASTILSLLAASASLVAAAPAAAPAPTAAAQLEDRATSCTFTNAASVKASKKSCATIVLNNIAVPSGTTLDLTGLNSGTKVIFEGTTTFGYEEWSGPLISVSGTSITVTGASGHVINGAGSRWWDGKGSNGGKTKPKFFYAHSLKSSTISGLNFKDSPVQLMSINGATSLTVSGLTMNNANGASLGHNTDAFDVGSSTGVYITGANIVNQDDCLAINSGTDISFTGGTCSGGHGLSIGSVGGRSDNVVKTVTISSNTIKNSDNGVRIKTVSGATGSVSGVTYKDITLSNIAKYGIVIQQDYKNGSPTGTPTTGVPITGLTLSNIHGTVASSGTDIYILCGSGSCSSWKWSSIAVTGGKKSTACKNIPSGSGASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUT6</accession>
    <name>A0A3D8QUT6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_10298</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUT6"/>
    <dbReference type="OrthoDB" id="3758478at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW65606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="179" mass="19389" checksum="A91702CEAB97B363" modified="2019-01-16" version="1">MTTMKIDPSAAARERTARIFIDTFATFSTGDCLLVRTPNCVQQFAPHSIAPPTMSNSAFAAHLAHLGEVMSSFPLTVKEMIDNPTANQVLIWATASPLWLPSVTGGVGKSGAGGEEVDWAYTGEYMFLLSFEDGEAGEDGNGGKLKRLERVIEFVDSKGTTKLYGLMEKARRILRGVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUU8</accession>
    <name>A0A3D8QUU8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_10234</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUU8"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000037">
        <property type="entry name" value="alpha-1,2-Mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF49">
        <property type="entry name" value="ALPHA-1,2-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="323"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="440"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="507"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="593"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="397"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW65542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="603" mass="68679" checksum="4F735DE2FE39E010" modified="2019-01-16" version="1">MVFGMRRWRATTLFAICFLFGLYRLHESRKQWDFTPSPLRLPSGYDKPPAKHDGLQHWHKRKERYPVTSHIQLPSGSYKQIPQIQAKPPTESPEAKAERLRRKAAVKQSFEHSWKGYKKHAWLKDEVTPNSGQWRDTFGGWAATLVDALDTLWIMGLKDDFEAAVKAAWTIDFSYTPQQSINVFETTIRYMGGFLAAYDISGGQYEVLLYKAVEVADLLMGCFDTPNRMPISRWDWRNYVDGYAQKAPSAILVSELGSLSLEFTRLTQLTGDPKYYDAVQRISDVLANGQNTTKLPGMWPVSVDAQTPSFDSDNMFTLGGMSDSLYEYLPKQYLLLGGLLEQPKIMYEKFIDVAKKELFFRILNPKDEDLTISGDVRASSDPNTAHHRIPRGQHLTCFTGGMVGMSAKIFNRPEELKLAEELTNGCVWAYDSLPHGVAAEIFSVIPCPKDGSCKYSDDKWHDAIVELYPAVGLSPDRKAAAVKAVEEHRLFPGYTSINDRRYILRPEAIESVFYMYRLTGNSTWADTAWRMFQAVEKLSRTSIAASAIDDITMPEPTLTDSMESFWLAETLKYFYLCFEDWDVVDLDTYVLNTEAHPLKRYGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYB2</accession>
    <name>A0A3D8QYB2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein-5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_09506</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYB2"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000191">
        <property type="entry name" value="Methylglyoxal reductase (NADPH-dependent)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW66757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="347" mass="37755" checksum="D5118248C7A7C190" modified="2019-01-16" version="1">MAQRVLLTGANGFVGSHILAQLLAQGSSVRSVVRSQAKADQVLADFPNYGSKLDFAIVPDLTAPGAFDQAVQSTPPFDTVIHTASPFLYRVAKDASDFLDPAIKGTLGVLKSVKANAPEVKRIVVTSSCAAVVDFTADPFASPQKVYTEDDWNPMTVEKALGGAENLNFFYQVSKKYAEKSAWDFLEQEKPNFDLVTITPPMIYGPLHHSVKSVKELNQSNGRIYDLFINSSKTADVPPNGMHVYTDVREVAEAHVKAATMPGASNQRFIVCAGRISSQNICDLLREAFPELSERTPEGKKGDAGLSPTAYTCSSERAMDTLGIQFRSPKETFVELAKQLLEIEKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYL1</accession>
    <name>A0A3D8QYL1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYL1"/>
    <dbReference type="OrthoDB" id="10572521at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017691385" evidence="1">
        <location>
            <begin position="20"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW66886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="732" mass="75014" checksum="B7F8D3DDF561EDD3" modified="2019-01-16" version="1">MHFFKLSLVFFSLYASSNAVALDRNHGLEKRDTTKTIISTAAGQIITRTLVTTVSGHTVTRTVVSTALGQVTTRTSVSTKAGQVTTRSFISTAPGAVTTRTVVTTAAGQVTTRTVVSTAPGQITTRTSVSTAPGQITTRTSLSTARGEITTRTVVSTAPVSITTKYSTITSSLLGRTITSTLPGQVTTRIVTSTALGQLTTKTIVSTAPGITITSTKSGAFVSVFSTIFGLTTKQASTVTLTEFNTSTQYATKYSTLVSTLPVSQITITAPGSVCTGTTSVSTRYSTVLSTVFSTYVTTQVTAVSGSLTTRTSTYSQPASTVTLYSTLFSTQTTAILGSLTTIVLPASTMTITTDSPVTVGVTSTLYSTFYSTLFSTQTTAISGSLTTVVLPASTTTVILPASTATATTTVTTDSPFTVEVTSTFYSTFYSTILSTQITAISGSLTTVVLPASTVTSLSIITSNILGDVTTVTADPQTATITESASTVYSTTTVTTEISGQPTTYTSTLSQPAETSIVYSTLTTDIAGALTTITTTLSGDVSTVTSYAVVDVTVTTTADPITTTVFSVSAGAEPTTVTSYAVVDVTVTTTADPITTTVFSVSAGAEPTTVTSYAVVDVTVTTTADPITTTVFSVSAGAEPTTVTSYAVVTITTAADPITITVISVSASAEPTTVTSYAVATVTTTADPVTITATNTATIPADPVTITTTAPADPIQTQNEKDITAAIRTQPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R2W5</accession>
    <name>A0A3D8R2W5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_09042</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R2W5"/>
    <dbReference type="OrthoDB" id="42889at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271:SF146">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW68385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="648" mass="73184" checksum="75977D00DA401920" modified="2019-01-16" version="1">MDDHLNSKPAPEIQSLQHWWLAHGGQLHPSIHIHWFGQSEGYGFQARQSIERPTEDASFYKVVSCPYTISLSYLNAIDASPTFSRHDSVPFPSAFLALPDHNPLGKVIIGYFFLMQQYLMGEKSFWYPYIRLLPQPNQPQRLGTAILWPEEDLEYLSGTNAEPAVRKYKEIWKNGYSTGYQLLQDHENWQLYTYDLYQWAAAVFGTRSFRPSLTLPEPWGELDAANEDAFSVLYPVLDIGNHMPAQPHYVKWIYSKTYDHVRDSVSLWSCKDVTMNDEVFNNYGSKSNSELLVGYGFMLPVEVNEDTVNLKLAAGGPRSGSRSQAEGMHLIFSRPRPCGDDRPLHLRYFSDGLVNLLLASLANMRERNVEGLEVFNSEASASPFGGHLARSMILAHLLLRDKLQTDLEKLRAQGESLEPPSNHNQSLAMEYRTRQMRVLQNALAPMDELIQGLFSHNSCVCTHFPDVGHNSITPAGVKILSLECAFDWLANLNPSLSGHVESIISQEQEEPLPLDWSVLVADWDHVFWSLWIYLVLLLPTTENSLGASLHGWTAALLSNHPDVIRSRQFFGDKDEAETFDAMLDLIDPFLQQIPSDSSYGGTATGKSTMKSLASFIAMEECFKADFPMLRGSKQQERVTQLVLCLPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R3M2</accession>
    <name>A0A3D8R3M2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09243</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R3M2"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="125"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW68586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="344" mass="37567" checksum="5EA03DD79D348F46" modified="2019-01-16" version="1">MSSQESGSYLEQATQALSSAASYMRLPVLVSSVLTAATGPRCSLLVAALLQAKVIPHGWCCGATTDHGARALIYPSHIPNAARTEVPRPSQFGLKNYEDLMIPTPDGENLSAFYIRSPQPSSRHANTTILMFHGNAGNIGHRIPIARMFANTMGCNVFMLEYRGYGLSTGSPDETGLMIDAQTGYDYLRQRAETREHDIVVYGQSLGGAVSIQLVAKNQGDRKLIGLVLENTFLSMRKLIPSVVPPAKYLAYLCHQVWASDTFLPSITEVPILFISGLLDEIVPPAHMRRLYEICQSPTKVWKPLPGGDHNSSVLEAGYFEAIAEFVGNLDSGDNEEGKTKMYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R3N8</accession>
    <name>A0A3D8R3N8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R3N8"/>
    <dbReference type="OrthoDB" id="2147163at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668:SF1">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47668">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G01940)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="36"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW68673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="261" mass="29759" checksum="DFC07FE87511005D" modified="2019-01-16" version="1">MQVQSKACCTRPPVTLNGGYDSYELKGKYIPYNGLKTYKTGPAGAKRGIFVVYDVFGLYIQSLKGADILAYNHEQQPDNAGEFQVFMPDFFGEHPQDLQNFPPKTPKQFKAISDFMNGYGYPPKTVPLIAPIMADIQKMHPEIKSWAILGFCWGGKIASLVCQEGTLFKAAAQCHPSLLDTEDAKKVTVPMCILPSQDEVPKVIGEWFHNLILNNPESYLEYFDDQVHGWMTSRADFNDIHRYEEYLRGYRIIRTFFSRFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R3V4</accession>
    <name>A0A3D8R3V4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09323</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R3V4"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF3">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="6"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW68666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="239" mass="25480" checksum="1DF89AD2524AAB36" modified="2019-01-16" version="1">MAKPTIVFVPGLWEGPAVFEGVASVLESHGYPTAYAPLASTGHASPENPNMLDDVRHIRSAIEPLVAAGKEIVMVCHSAGGCLGSAAIKDLDKKSRSQSGAEGGVIQLVLLAAALAPVGARHPETMPFFDVKGNEMFCLHPMNVLMNDLPADIGKSWVEKLQCQPATGWADAIEYCGWEAVPSVYLIATKDACIPIEMQMQAAEMASSKVEKIDCGHMIMLTQPNKVVEVVRRAAGEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7B2</accession>
    <name>A0A3D8R7B2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_08339</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW69942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7B2"/>
    <dbReference type="OrthoDB" id="5427872at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051219">
        <property type="entry name" value="Heterochromatin_chromo-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22812">
        <property type="entry name" value="CHROMOBOX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="5">
        <location>
            <begin position="182"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="85"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="151"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW69942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="238" mass="25817" checksum="CC35C02D08400483" modified="2019-01-16" version="1">MPRLESTSCEPTPTQTESPSAISSQASETKNKLGPSTPTKASNVGIKRGNACLDTPPTPSASPKQVAPAFKKTTVRKRKQTMAGGERRTSARIEMIKKQQPAASGSNSKTRMARSGPSTSATKKTTPAKKTGRGRPPKKGTGLTTKASATKKLESTSKNDKFDRPAAIKVGNQESGRFFAEYEVERILESRLKANDKVEYYVKWVGYPVEESSWEPASNLAHAEKKIADFNKMFPGKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7N3</accession>
    <name>A0A3D8R7N3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7N3"/>
    <dbReference type="OrthoDB" id="1263307at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF11">
        <property type="entry name" value="ESTERASE_LIPASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW70049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="29192" checksum="55EC6A72BB67ABEB" modified="2019-01-16" version="1">MSRPTFILTPTTNHPPSVYNNLATALFRHGYTSIKISLPTVLGPQSPVASSDFQPDVIALRNGLMTLVIEDEREVIVVMHGYSSLPGCEAVRGLSKRDREREGKRGGVIRLVFIMAWLPQEGFQSAERGDTSSFLPWVAVDEIVRSPPCSSLTLSLSPSSSPTSPQIPTRLTTQPTTGRNEYDQRAARAKDLIQRPPPRGSPVLDVTIAPAKSRRLLVPDILCCVAVHPEYVRALWTGSGRHSGVCRVDRASSEEVRGRVCLGSGGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7P9</accession>
    <name>A0A3D8R7P9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_08367</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW69970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7P9"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009688">
        <property type="term" value="P:abscisic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW69970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="269" mass="28682" checksum="49D1EFAFC55EF546" modified="2019-01-16" version="1">MGSNSAPTDSHLPVQTQITLGDKIIAITGANRGIGLGIAECCLANGAAKVYSIDYAETGDEFATLAKVYPGQLFALHADVTKEASITAAVDKILEEAGGLHGMVVNAGRTNHKSALDFTTEEIEGLFAVNLFGAFYTARVAARAFIKQNVKGAIVFTASMASYRPNKVVPSTPYGASKGGVRNMTHTLAMEWAQYGIRVNSVSPGLVKTAMTYWVEKQADWETQLKYYRGIPRLAEVQELGGAYVYLLSDAASYTTSIDIPVNGVIGIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R830</accession>
    <name>A0A3D8R830_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_08391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW69994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R830"/>
    <dbReference type="OrthoDB" id="5429770at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF1">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW69994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="518" mass="58455" checksum="2BFB260264B932D0" modified="2019-01-16" version="1">MVYCGKPSRSCRQCRKRDIKCDKRAGSCGQCTRANLKCPGYQNPEALVFRDQTASTIQKAADAPEDGFRKMKFTNYDPSVPSLSPCPTDLTPYPLPPVELRAKDVFVSQYVLRYSSMMGYIPHFLPSMYKPIHLMSTFKAVSLLYFSNEVMSPSVLDEAWTSYGFALSLTNKALQQPQAATQNSTLLTIFLLDLFERLANKRQLGMISDTRHINGALALFRLRGQSLFDDPLAVSMFSQLKVLMLTSCLEHNTDVPNDFIEIHKFASHSMDVEHPDWSFSVLLIRFIGVKARVCTRDNLSDAVQSALQLDDDFEQTCMNMPRSWHFDTITGLLIPDLTYEGCYHHYPSAEVCRTWNNYRLIRILLNEIILELLQNPEQGSFFNTAFVEAEQKIHTCNLTIERMCNEICASLPQFTREPSCFAVGANKTAQSAGMYMHGQISTSQRRSQATALVFALYTAASSPTCSSKNCSWIVNELQIMGSEMNISEARIVKDILLKKGKVNPWVIANTLELFTFGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDK0</accession>
    <name>A0A3D8RDK0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_08149</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4 10"/>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDK0"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF41">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016302">
        <property type="entry name" value="Man_a_manosd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017731183" description="Mannan endo-1,6-alpha-mannosidase" evidence="13">
        <location>
            <begin position="20"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="434"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="396"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW72115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="461" mass="49626" checksum="5BB6A2B4A4FAF8FF" modified="2019-01-16" version="1">MRPFNTFLRGLLLAPSVAAVTLNVTDPTSIKNAAATAAFGMMQYYQGNLSGQTPGILPQPLFWWEGGGMFMTLVDYWRYTGDTTYNSVTSQALLFQVGPNRDYMPPNQTKNEGNDDQGFWGLSAMLAAETNFPNPPPDQPQWLALAQAVFNEMVSRWDTTKCGGGLKWQIFPFNKGFDYKNSIANGCFLNLAARLARYTGNQTYAEWAERIWQWEESVNLIDSSYNIFDGTSDIDNCVTVDRLQWSYNAGIFLHSAANMYNLTNGNTTWQTRTQGVLDASKIFFNNSVMQEQACEPRGNCNTDQLTFKAYFAGWLAASSILAPFTGSRIRPLLASSASAVAQTCTGGSSKTACGFDWISKTFDGNTGIGQQMSALGVLHSAIASIENTTQQIAAPVTNSTGGTSVGDPNAGTAAASGQAPLTAATRPVTSGDRAGAGILTFMVVAGALGGSLFMTLELKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJJ3</accession>
    <name>A0A3D8RJJ3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_07659</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJJ3"/>
    <dbReference type="OrthoDB" id="3357846at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015244">
        <property type="term" value="F:fluconazole transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990961">
        <property type="term" value="P:xenobiotic detoxification by transmembrane export across the plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF23">
        <property type="entry name" value="FLUCONAZOLE RESISTANCE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="507"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW74217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="537" mass="59231" checksum="A0B4C7459FA11A23" modified="2019-01-16" version="1">MADFIRDTTFGQVARYSLGGRIFKFPEERPGFQLPGDHRRTSDDAPATNKVIRNCDSSSYPLNSSGRPRITAQQPSSGLGVPALASERIILVDWYSSNDPQNPQNWSTLKKSIVYIQVNLYTFTVYMSSSIYTSAETEIMHVFGTSQTVASLGLALYVLEIAAIGRNPPYVITFTLFVIFSTLAALVNNIPGLMILRFLQGFFGSPALATGGGSIGDITSPMSLPYGLYLWAIFATDGPAFGPLISGFSVPVEGWRWALWEILWTSGPALIGLVFLPETSSHTILLRRAKRIRKLTDNSAYRAQSEFDEVTLSPVRILSEALVIPWKINLLDPAILFTSFYCGLVYAIFYTFFEVFPLVYMDVYGMNLGEMGLVFLSVIIAAFLNSIPYFAYVHFVLNPATRKDCPVSPERRLLPALVASMLLPVGIMLFAWTSRSSIHWVVPTIGVMLTTGNTCLIIQCIYVYIAMVYPRYEASLFGANDFARAVVAFAAILWAEPLYGSLGVAKGSTVLGCRCFGCVFGIFALYLFGHYLRAGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RNI7</accession>
    <name>A0A3D8RNI7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_06434</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RNI7"/>
    <dbReference type="OrthoDB" id="6361347at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037473">
        <property type="entry name" value="Lcp-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018713">
        <property type="entry name" value="MPAB/Lcp_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37539:SF1">
        <property type="entry name" value="ER-BOUND OXYGENASE MPAB_MPAB'_RUBBER OXYGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37539">
        <property type="entry name" value="SECRETED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09995">
        <property type="entry name" value="MPAB_Lcp_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="ER-bound oxygenase mpaB/mpaB'/Rubber oxygenase catalytic" evidence="3">
        <location>
            <begin position="133"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW75613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="473" mass="53430" checksum="BF5BDD65045A7D08" modified="2019-01-16" version="1">MAWSNLFACKNEDTRHAWGYTFQWTPNHLTKEQMHPLKYSYDVLGEDALNALDRISPPDSRELPRNQSRRPTKEVPDAPPPSGRDLYALLRDHASEDPKLEALWNEVNNVPAWVDWQQIARGQDVFYRYGAVALTALAYQSLLGGMGAARVVEVLSRTGGFSANVARHRMFETTQHILQVTKSLEAIKPGGEGHASSIRVRLLHAAVRRRIMKLASERPEYYSVQENGIPINDLDSIATIGTFSATLIWLGFPRQGIWLKDQEIIDYIALWRLVAHYVGSPSSFFENPEQARHIMESILIAEINPSETSKALANNIILSLQGQAPSYASRDFLNANTRWLNGNELSDALGIGKPSFYYTALVAGQCIFFMALCYTYRSIPYLDKRKIKALRRIFWAVIVENKTHGLGKETDFEFKHIPNFHTNTAMGELKDTGLKESGIEQRNLRTLVIASTAVAAFSWIGMRIGYLIFRSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RNK2</accession>
    <name>A0A3D8RNK2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_06406</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDE2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RNK2"/>
    <dbReference type="OrthoDB" id="547031at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053822">
        <property type="entry name" value="SDE2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024974">
        <property type="entry name" value="Sde2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF1">
        <property type="entry name" value="SPLICING REGULATOR SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22782">
        <property type="entry name" value="SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13019">
        <property type="entry name" value="Sde2_N_Ubi_yeast"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="10">
        <location>
            <begin position="374"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="98"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="170"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="170"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="218"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="264"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW75585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="410" mass="44691" checksum="C47C003814EE9841" modified="2019-01-16" version="1">MASQTVNVLLTSFPGLDLPSTLSLPLPATTTISELQEHLQDRLPAHSNRLILTTISNKQLPTSSSSPISDLLSGPQDGFLSLRLSVPLCGGKGGFGSQLRAAGGRMSSKRKKNQGDENASSRNLDGRRLRTVNEAKALAEYLAIKPEMEKKEKEQRRKRWEQVVELAEKREEEIRSGSKGKVDGKWVEDKEEAGERTREAVLAAMKSGNYKDNLLGISPESASGSGVSESEDEEMGGMDSKGTTPPSETEVPKPQSKSMSFFGFDEDDEFMSSDADEEEEEEEEEEEEVGESEGEEEEENDENPVNDVEMVEDAPAQAVPAVEETIPAEPTILAEPTPASEPEPALEPESVVEPEPSAVEPVSQAQPKKVSQDYAKLKVPELKKLLQQRSLTISGLKADLIARLQESDSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RNN3</accession>
    <name>A0A3D8RNN3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Galactose mutarotase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_06523</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RNN3"/>
    <dbReference type="OrthoDB" id="274691at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004034">
        <property type="term" value="F:aldose 1-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033499">
        <property type="term" value="P:galactose catabolic process via UDP-galactose, Leloir pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09019">
        <property type="entry name" value="galactose_mutarotase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000014">
        <property type="entry name" value="Aldose 1-epimerase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008183">
        <property type="entry name" value="Aldose_1/G6P_1-epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047215">
        <property type="entry name" value="Galactose_mutarotase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091:SF6">
        <property type="entry name" value="1-EPIMERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G13240)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10091">
        <property type="entry name" value="ALDOSE-1-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01263">
        <property type="entry name" value="Aldose_epim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017740952" evidence="4">
        <location>
            <begin position="19"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW75702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="433" mass="47225" checksum="214D6D539A514B7F" modified="2019-01-16" version="1">MMLPRVFWLSSFVLTALALPQPQDSTEYTTGVAGNTTIAGDSASTVGPDKDGKYTIQAKGIRANFIPYGASISNLFINDSSGIERDIVGGFDNASYYSVDRQHPHFGGVPGRYANRIKNSSFVLDGTTYNVLPNENVVPGHPQGVDTLHGGPDGWDWRNWTVVAHTENSITFSIADPDGDQGFPGEVISYVTYTLTDHTWHLRMTAIPTTKKTPIMLSSHVYWNLDGWQNNETATALNHSLYLPYGGQRVGADTILIPTGDILSNQPGSVNDFKSAPKQIGANFSSPDLLGNCGFNCTGYDTCYLTNRDQAGPFDWKASGPVATLRSAWSGIQVDVHTDQEAFQIYSCSGQNGSMALKSTQGFFDDPSRPRVIEKYSCIVMEVEDWIDAINQPEWGRESKQIYEPGGDPYVLQARYEFSINTTAVGLLGPGSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPG1</accession>
    <name>A0A3D8RPG1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase M20 domain-containing protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_06659</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPG1"/>
    <dbReference type="OrthoDB" id="6119954at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016805">
        <property type="term" value="F:dipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05672">
        <property type="entry name" value="M20_ACY1L2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.360:FF:000004">
        <property type="entry name" value="Peptidase M20 domain-containing protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017439">
        <property type="entry name" value="Amidohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052030">
        <property type="entry name" value="Peptidase_M20/M20A_hydrolases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017144">
        <property type="entry name" value="Xaa-Arg_dipeptidase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01891">
        <property type="entry name" value="amidohydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575">
        <property type="entry name" value="PEPTIDASE M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30575:SF4">
        <property type="entry name" value="PEPTIDASE M20 DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037226">
        <property type="entry name" value="Amidohydrolase_ACY1L2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="2">
        <location>
            <begin position="200"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW75838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="426" mass="45718" checksum="3B36F05B716B1E00" modified="2019-01-16" version="1">MTRLVISPADSVRINIPFVPAQVASDNDEFDFISSYVDNVADKLWLVNKRIHDNPELAWKEFIAHETLTEFMKTMPGWKVTTSAYGIETAFSAEYDSGVPGPVVSFNAEYDALPGIGHSCGHNLIATASLSAAIATGATMKRFGLSGRVILFGTPAEEADGGKIKLLNAGAYKNVDVNLMSHPGNLSDNALVRTAAASFFKIEFFGREAHAAAAPWDGINALDAMVIAYTAVSALRQQTKPEDILQGMITNGGSAPNIIHAYTSGDWIVRANSRARANELVKKFKACFEAAAIATGATLKITETPGYDDQIPNWALGRSYRYYFNKLGGDIQEPHLDAVGTSASSDEGNVSHAIPSLCPSFKLDSEVGGHNPGFAKVAGTKESFLAALRVSKALAGTAIEVLGSEEYLSEIKEEWKKSILTAQDTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPV8</accession>
    <name>A0A3D8RPV8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_06943</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPV8"/>
    <dbReference type="OrthoDB" id="2129688at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="25"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW76122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="359" mass="41453" checksum="B5B759767F9703F5" modified="2019-01-16" version="1">MASPGGNGSSQAVRIHKFEWPGLQPDLRLEVFDSDEFHVHSTIMKLHSAFFRRFLDSPDKTADPSMPVRRGAFKYNWITKVDEDGSWALVSDTSQLTVKDKGYKLMRDRSEEIAVFCKLLKAIYRRDYIVDSVADLERLTRMADYYLALPALSFSLYMTLPKSHKFIAELIKCAPTIIETARKLRNTVLFRECLVYVMNPWDCPRYLDKKRGGKPLKDWNPALQKAFGAATINFHQQIVRVHQQLLDLRVEGGFSEFETGVLAKLKEEHEYTGGDRFPLPVFLQKLSYLCSSECESIYTEKGYDVEGIYDLEETLEELLDNQLTLSPKVTAGCDSFEEYLLCIKIEDELLPWDREQVDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPX9</accession>
    <name>A0A3D8RPX9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycosyl transferase family 25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_06963</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPX9"/>
    <dbReference type="OrthoDB" id="47375at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06532">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050757">
        <property type="entry name" value="Collagen_mod_GT25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002654">
        <property type="entry name" value="Glyco_trans_25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730:SF53">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01755">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017611639" description="Glycosyl transferase family 25 domain-containing protein" evidence="5">
        <location>
            <begin position="26"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 25" evidence="6">
        <location>
            <begin position="121"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="444"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="377"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="444"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW76142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="520" mass="58411" checksum="429D1BE83CF223C1" modified="2019-01-16" version="1">MSITVSRSFRITTIFLLLLWAFLWSLPRQRDTISSSVINTYKSSVSLLNTIDDDESKDLQLHLPPSPAEPYPDEIQELPEVREIQKSVEQVPIPVPVPVPAPAPAFSGELSDVMNATLGFQKIYVLSMPSRTDKRDALILSAHLTGIDLEFIDGVKPEEVSEKAVPLRWSKGTGGTLGCWRGHMNVYQKILKDRVQTAMIMEDDVDWEAMIKAQLTDFARGTRSLINSSLASWAPERPQAPSPYGNGWDLLFIGHCGLNNLAGKDREYWITENDPTVVTPEERKIQRQTRWARRPDWMLDNLAGNTTRVVTPVKSAVCLASYAISLQGAMKILYDQSILPNAIEIDNSLGKFCERGDGLCLAPWPSIFGTHVPAGDMSKDSDRQTSRPGRVREIPQSYDLTYPTRINLPTLIKGSTIVKAQYPEKVALKEIDLATYKHPEGKLFANKDDEKGKDKEKEKEKGKEKEKYTEKEKEKEHEKENKNVKEEEKGREEKGPEEPNKSSSSVDPKAAADLVEPKID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RQV5</accession>
    <name>A0A3D8RQV5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_07002</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RQV5"/>
    <dbReference type="OrthoDB" id="21678at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01823">
        <property type="entry name" value="SEST_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037460">
        <property type="entry name" value="SEST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981">
        <property type="entry name" value="LIPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37981:SF1">
        <property type="entry name" value="SGNH HYDROLASE-TYPE ESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="1">
        <location>
            <begin position="19"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW76181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="276" mass="29530" checksum="C91D0AFD0F83AB8B" modified="2019-01-16" version="1">MAAGSRATQSTGTRLHIVALGSSFAAGPGIQPQALKIAGRSQRNYAGLLAARLGAKLTDLTVSSATLKNVLSEPQVLYRNHFAPQLSAFPPDVDVVTITGGGNDLKYIAGMTLAAIRSSWIGRFISWFLPLTSNEEPLTTEAVAERFIAVIDKIRETSPQCQILLVEYLTLLGPDIHPGVDVPLKSAEIKQSQNIASELQKAYALAAEARDGCKVIPAADMSRDHGIGSDEPWVQGFSYGLLLAGGVPFHPNAKGMEAVSEMLYQELRSNDSLMIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RV77</accession>
    <name>A0A3D8RV77_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-like protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_05831</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW77979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RV77"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd01806">
        <property type="entry name" value="Ubl_NEDD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000023">
        <property type="entry name" value="NEDD8 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038738">
        <property type="entry name" value="Nedd8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW77979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="77" mass="8499" checksum="ADDDA185AA49B73D" modified="2019-01-16" version="1">MLIKVRTLTGKEIELDIESDYKVQTIKEKVEEKEGIPPVQQRLIFGGKQMADNMTAAEYNLEGGATLHLVLALRGGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVA4</accession>
    <name>A0A3D8RVA4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">M-phase inducer phosphatase</fullName>
            <ecNumber evidence="2 10">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_05854</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Tyrosine protein phosphatase which functions as a dosage-dependent inducer of mitotic progression.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>O-phospho-L-tyrosyl-[protein] + H2O = L-tyrosyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:10684"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="EC" id="3.1.3.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the MPI phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2 10"/>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVA4"/>
    <dbReference type="OrthoDB" id="26523at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000086">
        <property type="term" value="P:G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110032">
        <property type="term" value="P:positive regulation of G2/MI transition of meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01530">
        <property type="entry name" value="Cdc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.250.10:FF:000021">
        <property type="entry name" value="M-phase inducer phosphatase cdc-25.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000751">
        <property type="entry name" value="MPI_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828">
        <property type="entry name" value="M-PHASE INDUCER PHOSPHATASE DUAL SPECIFICITY PHOSPHATASE CDC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10828:SF17">
        <property type="entry name" value="PROTEIN-TYROSINE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00716">
        <property type="entry name" value="MPIPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6 10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rhodanese" evidence="12">
        <location>
            <begin position="366"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="145"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="237"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="507"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="145"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="513"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00067190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW78002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="556" mass="62376" checksum="8E901C44306C2501" modified="2019-01-16" version="1">MEASSPLAAMQAPSFMPSWGRNDMYTSHPHSLGGNTVFGPGSFNFRDLSMRRSSNDYFNAKPVRGSSPTASLAADLSQNFHIDMSPQLPTPRRSLFTSNLFGQFEVGRDCVTTPPLPSSSPGPLHEMMDISPLPHKQPYFSTQIEIESPTPGTTPNEEDSVLSSPPGASLSEAPRHTNGVDRRKTVMLRPSLMRTKGYSTNSMPRNPESQLPPFRFGAGASKLSTSTSMTLGECFMESPPQERRPQSANSPSVSIMGPPRSKHSFGSMNGNTRINGSPIGHSRRPSNPMLRPRKQFRRSLSMFESPGDIVQEKKESSPSCLQSVMDIDELHQPVLPHFFEEGQPDCIPRIKKDTLLEVLDGKFDEQFDQRMIIDCRFEYEFEGGHIDGAVNYNDKELLTTQLFQTSLPGKTLLIFHCEYSAHRAPIMARYVRKQDRTTNAECYPKLTYPEVYILDGGYSSFFQQHRERCFPQDYVEMDAKEHAYTCEREMGRLRQNRTKLSRAQTFAFGQGQMDDSPTAPNRSRSNNGGDMLMMGTNTTSPGLSYDRGHARRQVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVN9</accession>
    <name>A0A3D8RVN9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleoporin Nup159/Nup146 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_05979</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="248320at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000645">
        <property type="entry name" value="Putative nuclear pore complex subunit Nup159"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026054">
        <property type="entry name" value="Nucleoporin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039462">
        <property type="entry name" value="Nup159/Nup146_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23193">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23193:SF23">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16755">
        <property type="entry name" value="Beta-prop_NUP159_NUP214"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin Nup159/Nup146 N-terminal" evidence="6">
        <location>
            <begin position="58"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="468"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="516"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="592"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="667"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="764"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1427"/>
            <end position="1456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1474"/>
            <end position="1495"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1150"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1350"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="468"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="478"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="520"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="543"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="634"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="674"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="693"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="720"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="768"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="822"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="832"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="850"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="904"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="929"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="961"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="994"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1038"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1101"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1135"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1442"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1474"/>
            <end position="1484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW78127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1536" mass="159951" checksum="0A59A0AB9ECD2044" modified="2019-01-16" version="1">MAFSFGNAAAAAAAGPNTQSQAGPDLEDIQTEALGFLALAGESKLQLLPTPWPSDNLPQPTASLLSVASRKGLVAAAGPDVVIIATTESVRKAFEGPGSGGSNLKPFQPQLTLPMPMRISQLAFSSDETYLVLSAAEGGGLAVYDVQAILQGSTESAFQMSTNGQALRALIPNPSPERGEFIAVVTNDGNLMMANLKERSFVPGTNGQVLKDGVSCLSWSTQGKQLVAGLGSGSAIQMTPDGTVKAEIPVPPNMEPGHHTSSITWLENNVFLLVHTPSSFDNSSPPTSIYHVATRQPPSNFTFQKIADPAPPFGLNRSPPHHFLQRLRNFPPNIQDLIIVASTASTDIGLFSRSKVPLSGDKPADKITGVFTMTEMADDSRRAQLPMTGDLGDTSPIGIALDLSSKEKVVKPIPSDEMSESPTPLPGIMVLNNEGVLASWWVVYSESIRQGTVYPGLVIAEGVTQSAQGPAASSQPTPSAFGAPPAQPAFGQSAFGTPSTAAPAFGSASKVGSFGAPSGLGQTQSPWGAASTNAAPSSGPVFGSSTFGSTPASNPQTNKTPAFGSSAFGTPSTAAPAGGSAFGTPAFGSASTPGFGTSGLPGSRPSPWSSAAGTAPASAFGQPSGLGKSTSVFGSGASNPPSSGANVPSSGGFASFAQQGGFAAAVAPSSGSIFGSNNSTTPTSTGGSVFGTKSDNATTSNVFGKPSSPAPAAGIFSGPKPTTSIFGAPSTTQAGNPFGAPSQTNTSKSESVFGSNKFVLSSTFNADKSSEVDTPKSSGDADKSLFGGAFGSALGEVSKPSQAEAAVSQETDMNDDNAIEVSKSEEIKKEPSTTPMSTPAPSKFTSSTPASTSLFGSSTLTSATPMTKPVSSAGFGFGKPSMGGINIPPPETKTPGKLSNPSFFKKEPETEKKPSEALKGIPEAPLPPDSTTKPSFDNASGSSISNDAPLPPDFIPRPAIKTTETVPATATEPKATSSISADLIPPSDVPGGPEEGDDESDFLTEEDDSGNPSGEESDEEEEGSEEGSGEDVTKDLSPPQSSTKTAGFTPQSSFGGPASQSPVGGLFTNMQRPKQPNAGRSLFGEINQSAPVLPPPKLMASPRSPSPIRSAVGRLQRPDATRSVSLPGGPSHMLQKQAAKPTAPAQNLSVLLEQQRAEEQRRVAKRAQKEAEEKQALVDDEDEMTQKFLSSEITATRTLDDFVAHSDYVSTTAADSIPAQVETVYRDINSMIDTLGINARALRSFMKGHTEQYKEEGRTRQDLEDEQDWVLVEIEDLGSVLSKDLAHDLGAGRVQGVAAKLEVCSDLQKELTRLFARFEDIKKLVLTHVDADYRAIARAQPLSAEQAAQQHDLRKQFKEFQELLAKAEEELTVLKAAIASQSGGNNGKPVPTVEAVVRTITKMTSMAEKRSGDIDVLENQMRKLRFSSAASSREGSPFATPQHRTSTRIPGSSTYGLLYTPDNLRESSRNLQNSLMSSTSSFTRGSPPKKKMSLFSSEEKAQLRSKLARKKDVSIRLRAALHKTGTNVRSMDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWD3</accession>
    <name>A0A3D8RWD3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Putative phospholipase</fullName>
            <ecNumber evidence="4">3.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_06241</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = a 1-O-alkyl-sn-glycero-3-phosphocholine + acetate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17777"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30909"/>
            <dbReference type="ChEBI" id="CHEBI:36707"/>
            <dbReference type="EC" id="3.1.1.47"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine esterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.47" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWD3"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016715">
        <property type="entry name" value="PAF_acetylhydro_eukaryote"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272:SF7">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018169">
        <property type="entry name" value="PAF_acetylhydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="168"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR018169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR018169-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW78389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="531" mass="58597" checksum="F05477083673C380" modified="2019-01-16" version="1">MASYLTRLNPVPGFPEYTGPFKVGTIDVEIPISELESPSPTPDEAISTIQYRIFYPCEPESKGKPVNWLPSPQREHVAAYTRFLGASSTLAEVISFIPRLLHYVSIPVRKNAPLLQPSTPTKRWPVMIFSHGLGGSRNAYSHLVGSLASHGMIVIAPEHRDGSTPISYIRDVPSNNSMSEKSTAKKAKRTVDYRKLSHTPSPEVEAGRNAQLKIRLWELGLVHDSLLKLDEGKNLTNLNTSSTTLSGFMGQMNVHEPGKIVFGGHSFGAATTTQLVKSTFYSSEDYTAPSSYEPVFKPSPHSSIVQQITPHTPVVLLDVWCLPLRAASTKWLWEKPFPCYAPGGPGGSVLLAIESQAFVEWRVHLKATKRLLSPDPSSDRFDYGNGKIAMPHFYYPESSAHLSQSDFGVLFPWVTKKVFAAEEPERVMRLNVRAILQLLRSAGLPISPTSAADMELDPLTLEVKDDQAIFGSKKEVRGWKWLSTDVNELGDVDDETKAVGKRDEVKGNAEPAEAVIGNELLKQKQGTAERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWK6</accession>
    <name>A0A3D8RWK6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_06279</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWK6"/>
    <dbReference type="OrthoDB" id="308690at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990811">
        <property type="term" value="C:MWP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990810">
        <property type="term" value="P:microtubule anchoring at mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052778">
        <property type="entry name" value="Centrosome-WD_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220">
        <property type="entry name" value="WD REPEAT PROTEIN 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16220:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN WRAP73"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW78427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="60439" checksum="57F9F3176EB542B3" modified="2019-01-16" version="1">MTMQYSRTLKSSAQSLPSPDGAYIATILPSALTIRSTRSLEILHTRALPVDFSTSIAWFLWSNSSDRLLIATSDLIKIYSASDPQFKANIVNPTSGTVKITHISFGSSDNEVNVLSEFGLKLTVFNLLTSKSVDINSPKFFNRNVASRGLCYRPGTSNLTLLTRSGGKDILSIHARETLEVVRSWSLETVDAQGVSWSPDGRWLAVLESAGQGHKIFFYTADRYLYKVWNGPMPMTEEDRDIDLGAGVKYLEWSSTGAHIAIGDYSKRVTILAVPSFSEIMSFQHVPSLRPEETLQIWLEQVSPQNGVMARGFVKASQVTCPPTASLTPTTNKDVKSGTIAMAFDASGTLLATRTEDFPTSVWIWDVTTKILRANLILHAPVAKMTWHPKINELLMLRCEGEETKGLTHLWDPSWESPRIVDFASQLPGGKLIGKSIASWLNVDAVYPVIFFSDSQDCLLTSIADGANDDLPWEETSAKAFDIYGDREESPLNLVGADEKRPFRRVTVNLADAEADDSILDMCPSEESEEFDDTFQFKKAVDPTNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWQ8</accession>
    <name>A0A3D8RWQ8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="10">1.3.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BP5796_06290</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>5,6-dihydrouridine(16) in tRNA + NAD(+) = uridine(16) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53380"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="15">
            <dbReference type="Rhea" id="RHEA:53382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>5,6-dihydrouridine(16) in tRNA + NADP(+) = uridine(16) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53376"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:53378"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(17) in tRNA + NAD(+) = uridine(17) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53372"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>5,6-dihydrouridine(17) in tRNA + NADP(+) = uridine(17) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53368"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="17">
            <dbReference type="Rhea" id="RHEA:53370"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="14">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="16">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Dus family. Dus1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.88" evidence="10"/>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWQ8"/>
    <dbReference type="OrthoDB" id="272303at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF5">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="19">
        <location>
            <begin position="52"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="364"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="549"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="555"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RDW78438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="580" mass="64333" checksum="B8EDB6CE1DD13C9C" modified="2019-01-16" version="1">MTVSNGIARESTPVTSLQANNDSSNGTAAIPQSNKLHGRAFYESIGSPKFVLAPMVDQSEFAWRMLSRSFMSPETSKDLLAYTPMLHARMFTETPKFRDHHFQPMRSSLLLPVPAPPPASELFLDGNPSIDRPLFVQFCANNPDELLEAATYVAPFCDAVDLNLGCPQGIARKGKYGAFLQEDQDLIFSLINKLHQKLSVPVTAKIRILDTKEKTLAYARKVLSAGASILTVHGRQRDQKGHKTGLADWGMIRFLRDNLPKETVLFANGNILNKADIEKCLAVTGADGVMSAEGNLYDPAIFSDPPPLGEEGREYWRGRDGKGGWRMDAALRRYMDIIYKYVLEVPVPERNPLYLPSDLEEAVKTPTSEPVEQDGPPKKRQKTNGPVEKKERATNPNLVAMQAHLFHLLRVLVSKHHHIRDALAKCRAGDVAAFENVLQMVEKAVRLGLQEYEATNGRSYTQELENDARLAKLKEASVTAAEDGDKDGEIDEEYVKSLEVIKACKRPWWIVQPYVRPLAKEALMKGSLTLSKKEKAKLREEEIQAKKEDAALAGSTETQVVGTEGSTETVEVPKDGLICG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWS2</accession>
    <name>A0A3D8RWS2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ubiquitin-conjugating enzyme E2 2</fullName>
            <ecNumber evidence="2">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">E2 ubiquitin-conjugating enzyme 7</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">Ubiquitin-protein ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BP5796_06232</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine + [E2 ubiquitin-conjugating enzyme]-L-cysteine = [E1 ubiquitin-activating enzyme]-L-cysteine + S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="16">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWS2"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23796">
        <property type="entry name" value="UBCc_UBE2G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000008">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0882">Thioester bond</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 16" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="17">
        <location>
            <begin position="5"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="15">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00077195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDW78380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="166" mass="18759" checksum="9AD2E2AF9CB95100" modified="2019-01-16" version="1">MASSTAQRRLLQEYRALTNNPPEGITAGPVSEDDLLYWEALIQGPEGTPFEGGIFPAELKFPKDYPLAPPSMRFLGEVWHPNVYPSGLVCISILHPPGDDPNHYEHASERWSPIQSVEKILISVMSMLAEPNDESPANVEAAKQWREQRDEYEKKVRESCRRMLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWX9</accession>
    <name>A0A3D8RWX9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Endosome-associated ubiquitin isopeptidase (AmsH)-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_06196</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M67C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWX9"/>
    <dbReference type="OrthoDB" id="3640at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061578">
        <property type="term" value="F:K63-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140492">
        <property type="term" value="F:metal-dependent deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070536">
        <property type="term" value="P:protein K63-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08066">
        <property type="entry name" value="MPN_AMSH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000033">
        <property type="entry name" value="AMSH-like protease sst2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044098">
        <property type="entry name" value="STAMBP/STALP-like_MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015063">
        <property type="entry name" value="USP8_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947">
        <property type="entry name" value="AMSH-LIKE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12947:SF13">
        <property type="entry name" value="FI19924P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08969">
        <property type="entry name" value="USP8_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140856">
        <property type="entry name" value="USP8 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="10">
        <location>
            <begin position="358"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="178"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="229"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="273"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW78344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="532" mass="60181" checksum="C99611870B77D916" modified="2019-01-16" version="1">MAGSFQLSKPMTVKEISAKAQDFEFNPFVALKFWLRTAESLRREAQIYEAEENNQQAYLLLMRYAILITEVLPSHPSARDPTYRPALKEARKSLQDVFDRLEVLKPKIEARYALWLKALERRRQASAAVDDEHPQSQSRNDFSASDPAIAGNATAITAAEHEDYAVKVAHKEIRRRDAARRATRQAGVSEEEEQERRTAGLWDDWEAALSRDTQSGPDNEMQRAMIDSRRRLEAPHDILPDPARNRLTKANRTSSFPAQTTQNGSAYRYPSIARSQPLQFEESPNTRRTTSIRPASEIMPSRPPKERYDKPTTYSDLVLQDGPLQAAPELPPKTEESDPAYTFRPAAYLENGNPLRTVWINSRLRETFLKYASANTKANLETCGMLCGTLVSNALFVSKLVIPEQTCTSDTCETVNESAFFDYCASEDLMVLGWIHTHPTQTCFMSSRDLHTHCGYQVMMPESIAIVCAPSKNPSWGCFRLTDPPGMKSVLNCRQTGVFHPHAQDNLYTDALRPGHVYEVEGLKYDVVDMRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2U8</accession>
    <name>A0A3D8S2U8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glycoside hydrolase family 5 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_05188</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2U8"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000130">
        <property type="entry name" value="Endoglucanase C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF13">
        <property type="entry name" value="PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="6">
        <location>
            <begin position="74"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW80490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="470" mass="54562" checksum="75DBCD85FC338967" modified="2019-01-16" version="1">MSNGILRIQGEQVVDGNGKPVILRGAGLGGWMNMENFITGYPGHEAQHRAAMLEVLGQEKYEFFFDKFLQYFFTEADAKFFASLGLNCIRLPFNYRHFEDDMNPRVLKQSGFKHLDRVVELCSKYHIYTILDMHALPGGHNSDWHSDNPSNYAAFWDHKDFQDRTVWLWCELAKHYKGNPWIAGYNPINEPCDPKHVRLPAFYDRLEPEIRAIDPDHILWLDGNTFAMEWKGFDKVLPNSAYALHDYSGMGFPTGERFKGTEEQKSKLERQFLRKAQFQQKMKAVAWNGEFGPVYSDPLTDADAEEINQERYNLLGAQLEIYDKYQIPWSIWLYKDIGVQGMVYTSPDSKWNKTIAPFLEKKRALQLDAWGKHPSKQVSDVLDPFVQWIDKVCPQAKNMYPTPWFTERHIERATLQTFVSQAFALEFAELFRGMSLEELDECARSFSFEEVKKRDGLNTIMSAHAALVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2Z9</accession>
    <name>A0A3D8S2Z9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="11">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_05152</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 11">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the C-terminal section; belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="11"/>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2Z9"/>
    <dbReference type="OrthoDB" id="9402762at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF47">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 11" id="KW-0520">NAD</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="13">
        <location>
            <begin position="6"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW80454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="375" mass="40957" checksum="CDEED6E9AC92CB8E" modified="2019-01-16" version="1">MSVGTVLITGGTGYIGSFTTLALLDHGYKVVIVDSLYNSSKVSLDRIELLCGKRPDFYEVDITDEAALEKVFAAHPNIDSVIHFAALKAVGESSEIPLEYYRVNVGGTITLLRCMSKYNVPNIVFSSSATVYGDASQHPGMIPIPEHCPIGPTNPYGRTKSTIELVITDHINAQRNNLKKAGKPYEHWNGALLRYFNPAGSHPSGIMGEDPLGVPFNLLPLLGQVATGQREKLLVFGDDYSSKDGTAIRDYIHVVDLAKGHLAALNHLREKNPGVRAWNLGSGRGSTVFEMINAFSKVVGRPLPYEVVERRAGDVLDLTANPSRANTELGWKTELTLEDACEDLWRWVSNNPQGYRQDPPKELVEAAKAAAKKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3E6</accession>
    <name>A0A3D8S3E6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_05507</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3E6"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001716">
        <property type="term" value="F:L-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF382">
        <property type="entry name" value="AMINE OXIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017834154" description="Amine oxidase domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="2">
        <location>
            <begin position="188"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW80809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="691" mass="76368" checksum="C2B225A708938B24" modified="2019-01-16" version="1">MGRNSLYLAVLALFSVQIEGNVISRSSSIDFLGPLDVEVNGVHNIHIAYNNPLDGDLSIHYGECAQSSRSSIRTHHRVGTTSIGSSAFVKRNLEWIDSRPERFVWVVPASLPDRGCLHAYLNGEELVGVSQPINVIAKRSRRGVPIADYVDAEGPWFDGVKYISEKEPDEVFVAKAKGSTIGILGGGMSGLMSAHILDSVGITNWKILEASSRIGGRVHTSYLNSTTSSQYQYQEMGPMRFPVSVTDSTTNTTIQIKDHQLVFQTAAKLNEMNGNDPAYAVNFIPWIQSAANDPVSTTARRPDGTVPGKAEVAANPSLATNTTYSNATAAKEYMAAYDDWLGITNTSILAELGANIFKVHKEAVDKGVFDYSESEYLRFKLGAGLNITDEISGSGPNTDSWFYDDLYFIATEWRTIDQGLSRLPAAFGPQVLNRTMFQTVVQELAYNASTEKVKVSWRPGNPFDIEPESMEFDYVITAVPFSKVRLWKLPTFSSLLTRAIKSLNYEQSCKVALHYKTRFWEHLEHPIIGGCGSTNIAGIGSICYPSYKINSTGPGVMLASYSSGVFARTLASMTELDHVAYTQRAMIEVHGLIAQEQFTGAYDRICWEANEFQAGAWCAPLSGQQDLYLPAYFRTEMHTVFVGEHTSYTHAWIWSALESAVRGTTQLLLEMGLVDEAKQVTQDWMARWISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3G7</accession>
    <name>A0A3D8S3G7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Isomerase YbhE</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_05408</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cycloisomerase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3G7"/>
    <dbReference type="OrthoDB" id="9972196at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050282">
        <property type="entry name" value="Cycloisomerase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011048">
        <property type="entry name" value="Haem_d1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019405">
        <property type="entry name" value="Lactonase_7-beta_prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344:SF1">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30344">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10282">
        <property type="entry name" value="Lactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51004">
        <property type="entry name" value="C-terminal (heme d1) domain of cytochrome cd1-nitrite reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017567826" description="Isomerase YbhE" evidence="2">
        <location>
            <begin position="19"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW80710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="44560" checksum="4A31E37FE44F8507" modified="2019-01-16" version="1">MALDSLQVVLLLPQLLHSLCQSSSSWLAMRLHLSLGGLVTTAVATNLYVSSYIGTITTLQLSQAQNGSYALKQVAINNGSAPNPSWLTLDSTNGVLYCADEGLYVPDGSISSYSTSPSGQLKQIDRHTVISGPVHSVVYNDGKAQAFAHYTGSSVTTFSILASGGLQSLQNFTYTMSSPGPNPSRQEAPHPHEALLDPTGSFVLVNDLGADLVRVYSIDKKTSELIESTPFHAPPGSGPRHGSFLVSGNQTFYFLISELGNTIASYKLSYGNASLEFTQVFRSGTYGNHTVPTGAAAAECLVSPDHKFLLTSSRNDSLFHIDNFDANNSTKIPSDTLQTWEINPYTGELAFKQLSPAGGLFPRQFSVNKLGDLVAVGLQNSGRVVIVQRDIKTGTYGKFVAEIDIPGQVTSVVWDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3K8</accession>
    <name>A0A3D8S3K8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative MFS allantoate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_05544</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3K8"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF26">
        <property type="entry name" value="ALLANTOATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G09470)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="115"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="78"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW80846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="537" mass="60325" checksum="3422344322811A9F" modified="2019-01-16" version="1">MKTPADSPSSLDTKASVAHAETISPPVTSTTTQHKWNLSSHAADGDTALALFSNPDDLQEEISPADERALQRKIDFMILPYLAVCYAFFYIDKTTLSYAAIFGIREDLNLVGTEYSWLSSIFYFGFLAWAFPTNFMMQRFPIGKYLGINIFMWGFFLMLQATAKTFAQLAALRALSGAAEACSDPSFMLITSMWYTRRQQPVRIGIWYTANGLGIAGGGLLGYGIGQIKGSLPSWKYEFLIVGALCCIWGVVLFFFLPDSPVTAPLLTPKERRWAVERLRENQTGVENKHLKRYQVIEAFKDPKLYLFFLLGVVGNIPNGGISNFGTIIIKGFGFSTLVTTLMQVPYGVLIAICILFCVFLNDHVSRNGRQSRCYFIILFLLPNISGAFGLAFLAADNRAGRLICYYLTGPYNAAFVMILSLQTANTAGHTKKVVTNACLFLGYCTGNIAGPFFYKTSQSPRYQLGIWSMIVSHLLEVVVILTLRFLLKRENTKRDRIQGVHADETLDQKINREHERDRTAFSDMTDRENLNFRYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S400</accession>
    <name>A0A3D8S400_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_05686</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S400"/>
    <dbReference type="OrthoDB" id="3599616at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW80988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="14150" checksum="939DC398863BC400" modified="2019-01-16" version="1">MTKVPAAGYAVITLVFLYNAAYAFSWLYLVVAYPVEIAPYKWRARMWALTLSSIFISAFFNQYVNIAIEIAIIWKFFPETSGRTLEEIAVIFDGEAAAITNTVEDKATRARFRKSNRLVIPRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S9J3</accession>
    <name>A0A3D8S9J3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acyl-CoA dehydrogenase family member 10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW82920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S9J3"/>
    <dbReference type="OrthoDB" id="1694274at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02603">
        <property type="entry name" value="HAD_sEH-N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052898">
        <property type="entry name" value="ACAD10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829:SF1">
        <property type="entry name" value="HAD FAMILY PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47829">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW82920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="323" mass="35902" checksum="B314859175C88FDC" modified="2019-01-16" version="1">MRRPHPPASTTEPDLDPDTDEGADEGYSIEFILDGVEAIIMSEKRRPKVLLFDIGGVCVVSPFQAILDYELAHAIPPGYINHCISQTKPNGWWHRLERGEGLMDATWFAGFTADLHDEARWAAFYRSQATALNLPQEVPPQPRIDGEWLFWEMMRASREPDPWMFPALKALRASGQFILAALSNTMIFPPEHPYSFIAHDGVRSVFDVFISSAHVGLRKPDPAIYELALREVDAFARKNAATAQGRRLGWKEGVGASEIVFLDDIGENLKAGKKMGFETIKVPLGKAFEAVDQLESVTGLRLAGGHPRIAVEPRISMKGKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S9X7</accession>
    <name>A0A3D8S9X7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04395</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW82904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S9X7"/>
    <dbReference type="OrthoDB" id="4092340at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="263"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="425"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="444"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="506"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW82904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="558" mass="59983" checksum="5FC4E08F3F37045D" modified="2019-01-16" version="1">MDAGGLAQMSYNNFPSSNGLGVPTSGFAARRANGASVKRLSFETTKPVDSQDNGAPTPRTSRSHLLAGLRTAPKSTTSSTFPSTAPPTQLQHRTGLEHSMYADNKENQYGGPKTSNFTGQNTYQNGGRQMFPVAEQILAPPEIHVDEHGQEQMDPNLYAQLVATNMYLAEQQQRLQQQLMSVQQAAQQFQGMNLNMGVQQQFATPPVTPQNLYQQQVKQSMQPIITPVVGAQPGIYSYYNPMTGQQSYFMDNSFQQNQYLEQSMQQSAHYSPPQQPGTPRLQVSPPPQSETSRFARSISPPKKTSSPPQDHAPLPPPSAGAFRRGHRKANSMAISVNESAALDGPKSALLPKTMGFPNTPVSTFGPGNARAGEHPIRQPRGPPSLDELKAKPTAKFEGSKNFAARQRRSAVHNLVRAGMERRRAPGSSSGSMSPVSEAGEIAFSVSSDNDSDSGRSGSGSLSGRPALGGSRRSVHGAIGSNRPSSRQKEHSLERKSIASIDSHYTSASVSSDDGSVGGSFAAVFKNAGKKPETVEEKRKAPMLVFTSAEKRKSTSTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S9X8</accession>
    <name>A0A3D8S9X8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S9X8"/>
    <dbReference type="OrthoDB" id="40334at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42336:SF1">
        <property type="entry name" value="ALKYL HYDROPEROXIDE REDUCTASE SUBUNIT C_ THIOL SPECIFIC ANTIOXIDANT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42336">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="1">
        <location>
            <begin position="22"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW83156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="191" mass="21072" checksum="3AE85217F2F482EB" modified="2019-01-16" version="1">MTVQQELASWMSPPALNVSPVPEIGSEAPSSSALPLPNPNNKPTIVTFLRHCGCPFAEKTFKDLCAFANKHPEVNFTAVSHSDQASTDHWLESVGGKDSVPVIVDHERTTYARWGLGTSSAWHILSPWALYNVYKLGMEEGIWNRPTETGSRWQETGSAAIDKDGIVRWFHKPKTADERPDFSEALNALGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAG9</accession>
    <name>A0A3D8SAG9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">6-phosphofructo-2-kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_04622</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAG9"/>
    <dbReference type="OrthoDB" id="267323at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003873">
        <property type="term" value="F:6-phosphofructo-2-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006003">
        <property type="term" value="P:fructose 2,6-bisphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006000">
        <property type="term" value="P:fructose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003094">
        <property type="entry name" value="6Pfruct_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013079">
        <property type="entry name" value="6Phosfructo_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606:SF32">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10606">
        <property type="entry name" value="6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01591">
        <property type="entry name" value="6PF2K"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00991">
        <property type="entry name" value="6PFRUCTKNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="5">
        <location>
            <begin position="124"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="domain" description="6-phosphofructo-2-kinase" evidence="5">
        <location>
            <begin position="247"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="15"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="221"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="55"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="221"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="504"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW83131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="665" mass="74624" checksum="54B27794EEC56B81" modified="2019-01-16" version="1">MSNATAAASTHLKNYLADAKPLNNTNNTNDHRDAQRPTNVKHTDNSLSRAQESSNMHHEDVYKESTAKPDAGPTSAPSTAPTSPRLLPIRQNSGSSTPRIRPPATTLNIPGMTRSLASPDGRIAQRDVGAKLVIVMVGLPARGKSYITKKMRRYLAWQQHNTRIFNVGNRRRVAAGAQNTQTDSPAKAPIPQSAAYQGASTNGMDAPTQAAHILLNGVEHAQTDDSRPTSSDSKEPIAELPGPAPMDQSAGFFDPSNAKASQMREQVALSTLDELLDFLLDEGGAVGILDATNSTIERRKLIFDRIKAREPKLGILFIESVCEDKDLLEANMRLKLSGPDYKDKDPHKSLEDFKKRVAAYESAYVPLGRFEESQGMQYIQMIDVGRKVIHYQLKGFLTGGIASYLTTFNLAPRQIWITRHGKSIDNALGKLGGNSEITQEGREYGRVLYNFISQKKHEWTVEQKSKLLASHFPPQPGDNTPPYPEGIGEIDDKNFCVWTSMLKRSIQTAQDFQDDPDYDVKNWEMLNELNAGDCEGMTYEEIQAKFPEEYEKRAQDKLHYTYPGLGGEGYLQVISRLRDMVREMERITDHVLIIGHRSVARVLMAYFMDLTRDDIAHLDMPLGMLYSIEPKPYGIEFHAYKYDEEKLWFEELPNYKPHKEIERGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAX3</accession>
    <name>A0A3D8SAX3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Vacuolar sorting receptor (Mrl1)-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_04745</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAX3"/>
    <dbReference type="OrthoDB" id="4504960at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.130.10:FF:000024">
        <property type="entry name" value="Putative vacuolar sorting receptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028927">
        <property type="entry name" value="Man-6-P_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071:SF0">
        <property type="entry name" value="MANNOSE 6-PHOSPHATE RECEPTOR-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15071">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE RECEPTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02157">
        <property type="entry name" value="Man-6-P_recep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017758281" evidence="11">
        <location>
            <begin position="23"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="12">
        <location>
            <begin position="35"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="304"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="304"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW83254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="333" mass="35982" checksum="B2709EB001BC31DB" modified="2019-01-16" version="1">MLLPSLPTAALLAFALQSGVNAATTSDGKSKKAVEPCTITSSGGSFYDLRALSAERVAEGKKAAKGVRTEDWHSKGYDYNANFTLNFCAPVVDQVSDVIGIHDKARWGNVSAYYQQHGKVYSIGQQSSNLTLRGKRLVLQYENGSPCGSSENKKRATIDQDASIFAEDAPVRHKSTLISFHCEKDPVAQQAAPSFIGTDPDECAYFFEIRSAHACGGAEPTKQGVGPGAVFAIIGVIAILVYFLGGVFYQRNVAHARGWRQLPNYSMWAGAGNFIKDMFIIATSSCANIMPRSRGYSALSISANGNGSSGRSGRNSRDDENRLIDQLDEEWDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SCH0</accession>
    <name>A0A3D8SCH0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">T6SS Phospholipase effector Tle1-like catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_04959</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SCH0"/>
    <dbReference type="OrthoDB" id="3511947at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018712">
        <property type="entry name" value="Tle1-like_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33840:SF1">
        <property type="entry name" value="TLE1 PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09994">
        <property type="entry name" value="T6SS_Tle1-like_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T6SS Phospholipase effector Tle1-like catalytic" evidence="2">
        <location>
            <begin position="29"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="568"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="568"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW83468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="591" mass="68340" checksum="C36B62F718CEFA8F" modified="2019-01-16" version="1">MAPSADFPDYRPDPYHHHHEEGSKKRNGKRLIILCDGTWQDAESTPEKRKPPTNIIRLARAIKPEARVRGDDGTLVHVDQVVFYQSGVGTGTFDSLIGGTIGVGLSEKVRGAYAFLANNYLKGDKIYIFGFSRGAFTARAIAGLITKMGLLDKRGMDNFPLVYKEYYSMPKNLTLEEEEARYQDSRDKYNLYRPKLGALEAIGVFDTVGFHRPVTGYIPWLNSFIGEQYELNNTTLPTGVRYAFHALSLDENRYAFKPTLWYQPKEKIVYKENPNFETKMVQCWFSGEHSDVGGGKQDPRLSNISLGWMVSQLVEYDLLELDPDYLLEADNTDHKISAHRRWATVEGEGGKWWEGQNRIERLFLAFVFFWVGLLIDAAQFFGFQQFLGLRTPGMYHKEGFETNETIHKSVRDRKLNRANLDRKFYGPFGLWKRFSEPRWACKALRDWKMMDKLDEHGKPVLQMDRHGHQMYVLDKKGRPVPEEDKNGNPVYEKTWRKLVRGEVFKLDEERPTYLELRFKNNIRSANPMYAQEVFKFKKDCSKYHPFDSNGPYKEEMDTINAYANVNPSKLNGAHANNPQLNNKQGVVKDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SGN3</accession>
    <name>A0A3D8SGN3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_03842</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SGN3"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF49">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="318"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="437"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="43"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW85517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="482" mass="52635" checksum="16B490405F1248C8" modified="2019-01-16" version="1">MKIAGTSAENVEKGGLEVVGASEASIIDATKSKALVWKQDLRIVPLCAAIYLLCYLDRSNIGNAKTLNANKKHDLLDNTGMTSFQYTIALMVFLVAYAIFEVPSNYFLKKLNPSRWIAFLMFAWGCITIGLGGVHSFASVTVVRFLLGVFEAGLFPGLVYYLTFWYSTSERSIRVAFILASATLAGAFGGALAFAIGHMDGTHGLSAWRWLFILEGIPSVLSSIAVYFFLPDYPETAQWLSEEEKALAIARLQNEGSHGHSKSLTWSEAKMTLIDWRLYMHYAVYFGISVPFSSLSLFTPSITAGLGFENLESQLMTVPPYAVAYVVTILVSWSADHFNARALHSAALSTIGACAFLASALLPPTAYMHRYGCLIVACSGAFACIPPLLGWLSSNLHTTGAVGLAIALNISFGAPGQITGVWIYTANEAKKGYPTGHWVNAGMLFFVAAGCVLLRFYYMYLNRRLLRGGGVEDYGAKRLFRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SGN8</accession>
    <name>A0A3D8SGN8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Lactoylglutathione lyase</fullName>
            <ecNumber evidence="3 9">4.4.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_03791</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(R)-S-lactoylglutathione = methylglyoxal + glutathione</text>
            <dbReference type="Rhea" id="RHEA:19069"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="ChEBI" id="CHEBI:57474"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="EC" id="4.4.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit. In the homodimer, two zinc ions are bound between subunits.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glyoxalase I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.4.1.5" evidence="3 9"/>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SGN8"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00675"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004462">
        <property type="term" value="F:lactoylglutathione lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07233">
        <property type="entry name" value="GlxI_Zn"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004361">
        <property type="entry name" value="Glyoxalase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018146">
        <property type="entry name" value="Glyoxalase_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00068">
        <property type="entry name" value="glyox_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374:SF30">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10374">
        <property type="entry name" value="LACTOYLGLUTATHIONE LYASE GLYOXALASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00934">
        <property type="entry name" value="GLYOXALASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00935">
        <property type="entry name" value="GLYOXALASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9 11" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="VOC" evidence="10">
        <location>
            <begin position="9"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="VOC" evidence="10">
        <location>
            <begin position="168"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR604361-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW85466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="325" mass="37096" checksum="A9BBD2992AAB1B06" modified="2019-01-16" version="1">MSTDLKSYKFNHSMIRVKDPKESVKFYEFLGMKMIHKIEQPEAKFDLYFMGYDSPQSLSFGNHFTDREGLIELTHNYGTENDPNYKVATGNSDRGRGFGHTCISVDNLQAACQRLEDAGYKFQKKLSDGRMRHIAFVLDPDGYWVEVIGLNTLEKTEGITTTDVGTYRMNHTMIRVKDIEKTLKFYQDIMGMTLMRTSENPANKFNLYFLGYPGGKGIPGEAVDGVSATADREGLLELTWNYGTEKDESFKYHNGNDEPQGFGHICVSVDDLDAACTRFDDLKVNWKKRLTDGRMKNVAFILDPDNYWIEVVQNESLKESSHGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SGS6</accession>
    <name>A0A3D8SGS6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_03706</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SGS6"/>
    <dbReference type="OrthoDB" id="63935at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004074">
        <property type="term" value="F:biliverdin reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042602">
        <property type="term" value="F:riboflavin reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051606">
        <property type="entry name" value="Polyketide_Oxido-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43355:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE (NADPH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017679800" description="NAD(P)-binding domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="NAD(P)-binding" evidence="3">
        <location>
            <begin position="12"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW85381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="243" mass="26257" checksum="BDE30F04F256ACCC" modified="2019-01-16" version="1">MSSKTMTIAFLGASSGVGLAALKHIQAAGHQCIALCRYPEKLTAIFPPESHPNLKIVQGNAKDVAAVTRCLKTNEGKLVDGIVSTVGGKPILTKLTIDDPEVCRAAMFTLMEALAALRNEGVTGKPYIVVCSTTGISHFGRDVPCLLVPLYHVGLKVPHEDKKIMEDTLIASGEDFTIVRASLLTSGESETTIRVGIEDPKAGRESAAIGYTISREDAGKWIAERLFLQREEKYRNKIAMVTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SH15</accession>
    <name>A0A3D8SH15_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03887</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SH15"/>
    <dbReference type="OrthoDB" id="3903189at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW85562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="240" mass="26884" checksum="847D21E43349116B" modified="2019-01-16" version="1">MQDTNHFKGTYIIVIVAVNTFAQIEDTIVASTDVVFRTKEAKSLGIWNLTAETAMLTTLWGIKASFLITYHRLTQLRTLNKVVQGTAVYCAIGYVAVMVCLYAGFCHPFLEYFVEEPSNSHSVFNLGEIQHLPAQFQRVIRSAYHVYSNVTDGYLTNGMAKEAHNLLSFLPWYIRSDLRKPYQVLRIYITELPLGSVIIGTSYKMVGSSSSAGSAPPVPEVACYEFDKTPSAGYRRDLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHA6</accession>
    <name>A0A3D8SHA6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04008</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHA6"/>
    <dbReference type="OrthoDB" id="5201530at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017793646" description="Secreted protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW85683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="12695" checksum="8188AFE73F3D9E0C" modified="2019-01-16" version="1">MHFPTAILITAPLAVLAQTSAINVTKVETVDQTTREGDLAFGATNLAFGYSAGAGINFSNKTLGGGFNAGIPGASEGAIGGGWTLTADNLTFGFGGVYNNVSINVAIVGDKTTGSVSVTVNGKEIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHR7</accession>
    <name>A0A3D8SHR7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BP5796_04185</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHR7"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16292">
        <property type="entry name" value="CPSF3-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000001">
        <property type="entry name" value="Cleavage and polyadenylation specificity factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000004">
        <property type="entry name" value="Cleavage and polyadenylation specifity factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021718">
        <property type="entry name" value="CPSF73-100_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF11">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11718">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01098">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="12">
        <location>
            <begin position="36"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="13">
        <location>
            <begin position="262"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term" evidence="14">
        <location>
            <begin position="524"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="669"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="733"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="676"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="743"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="765"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDW85860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="841" mass="92977" checksum="072262D482D79E47" modified="2019-01-16" version="1">MATKRKAAAMAPAVEELVDPADELMFLCLGGGNEVGRSCHILQYKGKTVMLDAGMHPAYDGLAALPFYDDFDLSTVDVLLISHFHIDHAASLPYVLAKTNFKGRVFMTHPTKAIYKWLIQDSVRVGGASSNPTSQPVYTEADHLSTFPQIEAIDYQTTHTVSSIRITPYPAGHVLGAAMFLIEIAGLKIFFTGDYSREEDRYLVSAEVPKNVKIDVLITESTYGSASHVPRVERETALLKSITGILNRGGRVLMPVFALGKAQELLLILDEYWARHSEYQKYPIYYASNLARKCMLVYHTYVGAMNENIKRLFRERMAEAGTSDDIAGKGGPWDFKFIRSLKNLDRFDDVGGCVMLASPGMMQNGVSRDLLERWAPSDKNGVIITGYSVEGTMAKQIMQEPDQIQAVMSRNTGAGRRGPVGGEGDKVMIPRRCSVQEYSFAAHVDGVENREFIEEVAAPVVILVHGEHHNMMRLKSKLLSLNADKTVKVKVFSPRNCEELRIPFKADKTAKVVGKLASMPPPTEDQTQLLTGVLVQNDFKLSLMAPEDLREYAGLTTTTIVCKQHMTLSAAGVELVKWALEATFGRIEELPESKGKRMKNGNGDVHMNGSSEEADEEISTLRTAYLVMGCVTVRYGNQGHVELEWEGNMLNDGIADSVMSTLLSVESTPAAVKQSSSKHSHSHVHNHSENDNDNDDSTLHPRFRNIHASITPTERLERLFMFLEAQFGSDNLSPIELPRLNSTTTQKSLTDTTAKEIKSSSSSDSEAEPNDEDSLMTSQQSELARLHKLGIPVPGIEVKSASLVARIWLEDLEVECPNRIFGERVRAVVERATEVGAPLWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHX9</accession>
    <name>A0A3D8SHX9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11 12">Ferulic acid decarboxylase 1</fullName>
            <ecNumber evidence="10 12">4.1.1.102</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Phenacrylate decarboxylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="primary">FDC1</name>
        <name evidence="16" type="ORF">BP5796_04207</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the reversible decarboxylation of aromatic carboxylic acids like ferulic acid, p-coumaric acid or cinnamic acid, producing the corresponding vinyl derivatives 4-vinylphenol, 4-vinylguaiacol, and styrene, respectively, which play the role of aroma metabolites.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(E)-4-coumarate + H(+) = 4-vinylphenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:33227"/>
            <dbReference type="ChEBI" id="CHEBI:1883"/>
            <dbReference type="ChEBI" id="CHEBI:12876"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="EC" id="4.1.1.102"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>(E)-cinnamate + H(+) = styrene + CO2</text>
            <dbReference type="Rhea" id="RHEA:46920"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15669"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:27452"/>
            <dbReference type="EC" id="4.1.1.102"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(E)-ferulate + H(+) = 2-methoxy-4-vinylphenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:33807"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:29749"/>
            <dbReference type="ChEBI" id="CHEBI:42438"/>
            <dbReference type="EC" id="4.1.1.102"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>prenylated FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </cofactor>
        <text evidence="12">Binds 1 prenylated FMN per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer. May form higher order oligomers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the UbiD family. UbiD-like/FDC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.102" evidence="10 12"/>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHX9"/>
    <dbReference type="OrthoDB" id="4878259at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046281">
        <property type="term" value="P:cinnamic acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033494">
        <property type="term" value="P:ferulate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1670.10:FF:000004">
        <property type="entry name" value="Ferulic acid decarboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1670.10">
        <property type="entry name" value="UbiD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01983">
        <property type="entry name" value="UbiD_FDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032903">
        <property type="entry name" value="FDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002830">
        <property type="entry name" value="UbiD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049381">
        <property type="entry name" value="UbiD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049383">
        <property type="entry name" value="UbiD-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048304">
        <property type="entry name" value="UbiD_Rift_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00148">
        <property type="entry name" value="UbiD family decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108">
        <property type="entry name" value="3-OCTAPRENYL-4-HYDROXYBENZOATE CARBOXY-LYASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30108:SF17">
        <property type="entry name" value="FERULIC ACID DECARBOXYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01977">
        <property type="entry name" value="UbiD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20696">
        <property type="entry name" value="UbiD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20695">
        <property type="entry name" value="UbiD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143968">
        <property type="entry name" value="UbiD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="8 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0464">Manganese</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like N-terminal" evidence="14">
        <location>
            <begin position="25"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like Rift-related" evidence="13">
        <location>
            <begin position="129"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="3-octaprenyl-4-hydroxybenzoate carboxy-lyase-like C-terminal" evidence="15">
        <location>
            <begin position="334"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="292"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="179"/>
            <end position="184"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="201"/>
            <end position="202"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="202"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="401"/>
        </location>
        <ligand>
            <name>prenyl-FMN</name>
            <dbReference type="ChEBI" id="CHEBI:87746"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00072003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF20696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDW85882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="513" mass="56665" checksum="5548CBF80869CB11" modified="2019-01-16" version="1">MSTEKSHHLSKSNQDLPHMNFRSFVEALREDGDLAEIMDEIDPNLEAGAIIRKVCETDDKAPLFHNMKGAKDGLFKILGAPASLRKDPGQKFGRVARHLGLPPTASMRDICDKMLSAAHAQPIPPTVVGDGPCKENKLFGNEIDLSILPAPLLHQADGGKYIQTYGMHIVQSPDKSWTNWSIARAMVHDKNHLTGLVIEPQHIWQIHQMWKKEGKDVPWALAFGVPPAAIMASSMPIPDGVTEAGYIGAMTGNALDVVKCETNDLYVPANSEIVFEGTLSITETAPEGPFGEMHGYVFPGDVHQCPKYKVNAITYRNGAIMPVSGCGRITDETHTLIGSLAAAQIRQICQDAGLPITDAFAPFETQVTWVALKVDTKKLKAMNTTPEKFRKMVGDLIFYCKAGYTIHRLVLCGEDVDVYNGKDVIFAFATRCRPNKDETFYEECRGFPLIPYMSHGTGSPVQGGKVVSDALMPAEYKGEQDWQQASFKHSYPEELQESVNARWTKVWCFSESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SI07</accession>
    <name>A0A3D8SI07_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_04248</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SI07"/>
    <dbReference type="OrthoDB" id="2283488at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF26">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW85923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="571" mass="64164" checksum="3388AFBADC4D16F1" modified="2019-01-16" version="1">MPPSRSSAATRACDSCRRRKVKCDATEVCANCRISQLSCRYTSVPRKRGPKVPGTPRIQRPQDHGPIADDQLWLSPVSYTEHPEPGEATSSSQSGQLANIFSQPVAETTLGPTPEWAQSVRDGLLAFMSSALPAVPALEAVNKCIDVYMQYTFPTTPMVHEPTLRASASRFFSSTGTTDLFEGQTQQEEIARIQAFSLITALCASVSSVMPDSLLPHRQILASPCLEASREMLKAIEDYDIENPNSSSIVIRIFHATALQHLTGKTALSYFILGQATLLIRHMRLHSEEALMSHDALEGQLLRYIFWQLYAADKASICLSSRPVLLHELLFDEEPSLRQSGETLIPLLDVTRPWYGESFEERLLVGFHFLPRLWSSAASLIFDMRLYARDNQHANKAHLTQTYMEFLGIMDGLPPWLQAANVIITHDDGEAAQFQKTAFWVQRCTVLVTFQCLRLVILQQCIESKVWDVMGLNDQALTLPMTKIGMVHDFVQTLDDIPFVYLQVKGEPTVERIRRVGSVLLEIIDNVSNETIIMRAEHYFTRLLDLLARLDSKSSDVLAELKELSQARRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SJ45</accession>
    <name>A0A3D8SJ45_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GST N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_04133</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SJ45"/>
    <dbReference type="OrthoDB" id="2098326at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03046">
        <property type="entry name" value="GST_N_GTT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF9">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="5"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW85808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="266" mass="29610" checksum="03B958ED3402213E" modified="2019-01-16" version="1">MASTGIQLTLHWLNRSRAQRIIWLLEELRLQYRLVTYERLPDQQAPPSLKAIHPLGKSPVLEVNNSRTKKTLVLAESANIVQYITEHFGQHLIPKKWQDGLEGEVGGETDEWMRNSYYMHYAEGSLTALIAAGALKNGIKTATVPFFIKPLTGMIAGKIETDYLNHNFNAHLSFLESEMSSISKAANNLSPGESSTADGPFISGLKLTPADFMMAFPLEAAQQIAGLTKTKYPFLTDYVARVQSREAYKAAIEHIIEQTGTYEPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SLN0</accession>
    <name>A0A3D8SLN0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_02943</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SLN0"/>
    <dbReference type="OrthoDB" id="3564380at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF53">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017757233" description="FAD-binding PCMH-type domain-containing protein" evidence="5">
        <location>
            <begin position="18"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="59"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW87249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="174" mass="18252" checksum="F38A1D76DEBD7EE6" modified="2019-01-16" version="1">MLSHLATIIISVAVANACTSASSCCAVLCSSEYLVDKVSSENTTAYNDTIYSFWSGQARTDTPTCVVEPTAASDVAVDVAILAEYECQFSIKGGGHTPWARAASINDRVTINIAGLNSMSLNTNKSIAYLGSGSRWGPIYEYLESQGTMVSRGRASDIGIGGLVVGGGYSWFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SLU0</accession>
    <name>A0A3D8SLU0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial</fullName>
            <ecNumber evidence="20">1.3.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BP5796_02964</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15 20">Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 20">
            <text>a quinone + succinate = fumarate + a quinol</text>
            <dbReference type="Rhea" id="RHEA:40523"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.3.5.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="18">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="18">Flavinylated by SdhE, about 5% flavinylation occurs in the absence of SdhE.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 20">Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 20">Mitochondrion inner membrane</location>
            <topology evidence="1 20">Peripheral membrane protein</topology>
            <orientation evidence="1 20">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.5.1" evidence="20"/>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SLU0"/>
    <dbReference type="OrthoDB" id="71672at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER01006"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008177">
        <property type="term" value="F:succinate dehydrogenase (quinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006121">
        <property type="term" value="P:mitochondrial electron transport, succinate to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.700.10:FF:000001">
        <property type="entry name" value="Mitochondrial succinate dehydrogenase flavoprotein subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.80.40:FF:000002">
        <property type="entry name" value="Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000482">
        <property type="entry name" value="Succinate dehydrogenase complex, subunit A, flavoprotein (Fp)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.100:FF:000001">
        <property type="entry name" value="Succinate dehydrogenase flavoprotein subunit (SdhA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.100">
        <property type="entry name" value="Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.80.40">
        <property type="entry name" value="succinate dehydrogenase protein domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.700.10">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003952">
        <property type="entry name" value="FRD_SDH_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037099">
        <property type="entry name" value="Fum_R/Succ_DH_flav-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015939">
        <property type="entry name" value="Fum_Rdtase/Succ_DH_flav-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030664">
        <property type="entry name" value="SdhA/FrdA/AprA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027477">
        <property type="entry name" value="Succ_DH/fumarate_Rdtase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011281">
        <property type="entry name" value="Succ_DH_flav_su_fwd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014006">
        <property type="entry name" value="Succ_Dhase_FrdA_Gneg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01816">
        <property type="entry name" value="sdhA_forward"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01812">
        <property type="entry name" value="sdhA_frdA_Gneg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE 2 FLAVOPROTEIN SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11632:SF51">
        <property type="entry name" value="SUCCINATE DEHYDROGENASE [UBIQUINONE] FLAVOPROTEIN SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02910">
        <property type="entry name" value="Succ_DH_flav_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000171">
        <property type="entry name" value="SDHA_APRA_LASPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46977">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56425">
        <property type="entry name" value="Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00504">
        <property type="entry name" value="FRD_SDH_FAD_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 20" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 18 20" id="KW-0274">FAD</keyword>
    <keyword evidence="6 18 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="13 20" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11 20" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 20" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 20" id="KW-0813">Transport</keyword>
    <keyword evidence="5 20" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <keyword evidence="23" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="21">
        <location>
            <begin position="62"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarate reductase/succinate dehydrogenase flavoprotein-like C-terminal" evidence="22">
        <location>
            <begin position="512"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="16">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="67"/>
            <end position="72"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="90"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="406"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="440"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="451"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <begin position="456"/>
            <end position="457"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Tele-8alpha-FAD histidine" evidence="19">
        <location>
            <position position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00059077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000171-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="PIRSR" id="PIRSR611281-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU362051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF02910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="RDW87270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="648" mass="71042" checksum="8A729F0716AF695A" modified="2019-01-16" version="1">MKSFSQRLRPLVQAHSWWRGEYAKPYTRGYISATSRRKAKPVSSFDGVGSGKEYLMVDHHYDAIVVGAGGAGLRAAVGLAESGLETACVSKLFPTRSHTVAAQGGINAALGNMTEDDWRWHMYDTVKGSDWLGDQDAIHYMTREAPKAVYELENYGMPFSRTSEGTIYQRALGGQSLKYGIGGQAHRTACVSDRTGHAMLHTLYGQSLKHNTNFFIEYFALDLLMVDGSCVGVLCLSLEDGTLHRMFARNTVLATGGYGRAYFSCTSAHTSTGDGNAMVSRAGLPNQDMEFVQFHPSGIYGAGVLITEGARGEGGYLLNGNGERFMERYAPTAKDLASRDVVSRSMNMEIRDGRGCGPEKDHIYLQLSHLPPEVIHERLPGIAETANIFSGIDITRQPIPVLPTVHYCMGGIPTNYKGQVLSVADDGSENIVDGLYAAGEAACVSVHGANRLGANSLLDIVVFGRATALHIAENNSKNAPHRQVPADIGSTSLQDLERIRTAAGDVSTSQLRLDMQKAMQSDVAVFRTESSLSEGYSKVQEVGESFRDHLRVSDRSLVWNSDLVETLEMRNLLTCAAQTARSALERKESRGSHAREDFPKREDAHWLKHSLTWQQGEADDVRVGYRDVVMKTLDEKECANVPPKERSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SM83</accession>
    <name>A0A3D8SM83_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_02988</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SM83"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000006">
        <property type="entry name" value="General amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF18">
        <property type="entry name" value="AMINO ACID PERMEASE_ SLC12A DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="87"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="53"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW87294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="550" mass="60087" checksum="5A39798ABCD5FD05" modified="2019-01-16" version="1">MSSEDIEKNGSVPVYEKQVVYTSADGAPSDLQEENATEFVETHELRRGLEQRHIQMIALAGTIGTGLFLGSGRAITNGGPLGALMGYTFVGILVSAVVISIAELSALVPLSGAIIRHAEYFVDPALSFANGWNGVYGSMVSLPAELVAAAVIVQFWSAISPAVWIVVFGAILIVSNLFFVRIYGELEFTFASLKIMLIIGLNIMALVIVCGGGPDHHVYGAQYWRNPGPFVQYLGFSGSLGRFMGFWTTFSNAIYAYSGVEGISVAAAETQAPRRNIPIAAKRIFWRVCIFYILSIFMVGLLVPSNDPSLLASTGTASESPFVIAATNAGIKVVPSIINFVVLTSAWSAGNSGLLGASRSLYGMAREGHAPKIFLRINRFGIPYVAIGFFSLFICLGFMTLSSSASTVFSWLQDLVSVSALVNWMVICIVYLRFYYGCKKQGIDRNELPWKGPFQPYAAWIALVMFTILLLTGGYTVFIHGEWSTETFVSSYINIPIILILYFGYKFIMKSKIVSLEEMPIRHFLDIAAANPEPAAIKPTGWRRFNILWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SNK6</accession>
    <name>A0A3D8SNK6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative dialkylglycine decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_03607</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SNK6"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688:SF13">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW87913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="428" mass="45943" checksum="72849C0C5B24FB77" modified="2019-01-16" version="1">MTTGVPSSPVIITKAKGTRLYDANNGQILDFTSGQLSSLLDHSHPKIVEVVKKYVEELDHLLSNMITQPVIDLTERLARFLPGSLEKSFFLNTGSETTEAAIKMAKCYTGRFEIVAFSASYHGLTQGSGSTTYSAGRKNGGPSMPGQLAFPAPYAYRSFFKKPDGAYDWESELEIGWSLIDRQSVGSLAAFIMEPILSTGGILEPPLGYLARMSVECKKRGMLLIMEEAQTGVGRTGQMFAFERDGIVPDILVLSKTLGSGLPLASGSTTAEIERGCREAGFLWLTTHLNDPLTAAVGNKVLEIVERDNLCQRAAERGQQLRSGLLRLQQKYWCIGDVRGRGLLQGIEIISDAASKTPGAELGQAVSDRAMAGGLSCNVVNLPGMGGVFRLAPPVTVSVEEIEEGLQILDEAFGYVLGAGAPAQSENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SNM4</accession>
    <name>A0A3D8SNM4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_03092</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SNM4"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000061">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF134">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="485"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="510"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="558"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="582"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="129"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW87398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="615" mass="67609" checksum="AB5DE33971DBEFF7" modified="2019-01-16" version="1">MATCEEEIFHASEKKDVVPDARDANEQEGTEITTPRSSEVYVSSALKSTSAANEEKFVSPTDSVSDTLADFAGCDMDMSTPITYHYLTFETLLPSPRLSPSSTSALPPQPNLKKFQSPFDWPKTRKSLTIWMSCMATLVSSYAAGSYSSGSHQMEAEWHVSAVAINVGITSFCCGFAIAPMVLAPFSEINGRYPVFVLSGILFVVCQICCAVTQSYAGMIVARFFVGCGSSVFSSMVGGVVSDMYHSKERNNPMALFSGGALFGTGLGPLVSGFIAQHTTWRWIFWVQVMTNGILMAAFALFYSETRGNIVLSRKAKALNAWYAKCEEMGHFGLELVVPDLQSPARPQRIRWKVKTDEDRQSIGQMVQISVYRPFHLLFTEPVVFFFSLWVSFAWTVLYATFTSIPLVFSRSHGFSVEQSGSVFSVLSIATVIATILSIWQEKLLGNAIARRGEKKSTDSLGGTATQTSRFTLRRLDLTSPEARLYFACAESVLLPIGLFMFGWTQFHSIHWIVPTIALGLATMGIFFVYLSTFNYLADTYHRYASSALAAQSFCRNIIGGIFPLFTVAMFNNLTFQGAGSLLGGLGALLTLVPWVLVYAGPTIRARSKFASEIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SNX5</accession>
    <name>A0A3D8SNX5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WSC-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_03575</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SNX5"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051589">
        <property type="entry name" value="Sialate-O-sulfotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964:SF5">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017802876" evidence="3">
        <location>
            <begin position="22"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="4">
        <location>
            <begin position="156"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="350"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="354"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW87881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="732" mass="76536" checksum="3E598C7F821F9892" modified="2019-01-16" version="1">MHIKAHLFFFLALLTFPGSNAQNVQCVTVADGCDRGSSEESGVTSAISRFEDAQIYGGSDPIVMSSAVNGDALAMITYLCNDGSAPPKLEGSVIRSSLQKVLSCPNRCGGVASPNNGNCGFGVLIASNAATTDCFSKAVNVVPKGSSPQIVPSVSSFGNPVCLMDSAGARVLTGGTSQDQSSTGMTVEKCIAQAAADGWRYAGVEFGGECYWGDTETNPQQSNPGDCSTPCAGDPNEICGGGNRILIYENSNLQDVANAKVSVDNYNSDPSNTALAQTAKTAIDIALNHALSFLDHIVNPLVKAAQQQLIQDLTAASTTAATAVTAASVAVAAVLADQIAKAVASEQAVQDAKSQQPSQPVSEPPASITKPSTSAPSRSSTSSSTSSSSSACPLCVSCADDQNPETGPEDSTTVPERRSKFGKRANSRKETVVCGTTYQSGPYLAGNGGNRFPAFGYQYTVNTQSACVWDFRLLTWDPTQGGAPAATKGGSYETEHVYEAQLVRQFAEHIGTLDMGTACRPAGFTKNILARTSNFPGRRNNPFTARGGSALGQMMLNLPDNNSGAGNGAELVALDKELNILKAAVFNGATTSFSTANVAPGKLAKVTRFAMLYAYLSTPEVAAIFKATSQRMRATLRTLDQEIAASSMANPGIVFETVYSTWEDNFLFTQGALVETVMDGLVTAAITQLRTDTSLGSQTLRNSFVTQVQAKTASLAVADPSKWFDLDELFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXZ9</accession>
    <name>A0A3D8SXZ9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WKF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_02304</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SXZ9"/>
    <dbReference type="OrthoDB" id="10261563at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019327">
        <property type="entry name" value="WKF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22306">
        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22306:SF2">
        <property type="entry name" value="CHROMOSOME 7 OPEN READING FRAME 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10180">
        <property type="entry name" value="WKF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WKF" evidence="2">
        <location>
            <begin position="197"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW91139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="440" mass="48158" checksum="00A47408BBC8DBBB" modified="2019-01-16" version="1">MPSATTSSNALSPRIPAWKRLGLKLKFASETPEPTAIPVTSTESSPKPLQRQQNKRKADSGVETPTKKAKTTARTEDVVASDSIPTLSRKKSVTFTPETKEKDGDSIKQLFSAWVAEQKALDPTFGATSTSPALSIPEPPKVEEQVDSTLEESERRVKRVKKPKSERSKASEKQSGASIIKPTSTKPSSAPTRPFLAYLRQYHESRDTWKFNKNHQDRILKHIFDVDTIPSDYSHLLYEYVRGLQGGVRTRLRDSALAVKVKDQEEGVAGFPKDMANPLKRQQDYEVAMKDYVATMTAAGAHSKMGYEEGIILNLSDAAMGKRAIKRMRSEQILQELGAPQEQKSEVNDDAQKRLRLADGSIQKLGRRRKQRTTAMESDTSSSDDSSDSDSDSDTSSDDSDAAQGNVAHDDSSSSSSSSSSSSDAESESDASESDSDGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SY23</accession>
    <name>A0A3D8SY23_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_02324</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenosine(1779)/adenosine(1780) in 18S rRNA + 4 S-adenosyl-L-methionine = N(6)-dimethyladenosine(1779)/N(6)-dimethyladenosine(1780) in 18S rRNA + 4 S-adenosyl-L-homocysteine + 4 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42780"/>
            <dbReference type="Rhea" id="RHEA-COMP:10234"/>
            <dbReference type="Rhea" id="RHEA-COMP:10236"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74493"/>
            <dbReference type="EC" id="2.1.1.183"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8 9 10">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SY23"/>
    <dbReference type="OrthoDB" id="74991at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052909">
        <property type="term" value="F:18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000007">
        <property type="entry name" value="rRNA adenine N(6)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020596">
        <property type="entry name" value="rRNA_Ade_Mease_Trfase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF7">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01131">
        <property type="entry name" value="RRNA_A_DIMETH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 9 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 9 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA adenine methylase transferase N-terminal" evidence="12">
        <location>
            <begin position="47"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="40"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW91159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="384" mass="42694" checksum="DC00C4CED926047B" modified="2019-01-16" version="1">MGKLKQGKRNSAASASASPYSKAQAQTNNVFKFNTNVGQHILKNPGVAEAIVAKANLKPGDVVLEVGPGTGNLTVRILEKAKKVIAVELDPRMAAEVTKRVQGKPEAKRLEVMLGDVIKTELPHFDVCISNTPYQISSPLVFKLLALPNPPRTSVLMFQREFALRLTARPGDALYCRLSVNAQFWATITHIMKVGKNNFRPPPQVESSVVRIEPKIGTDRPGVSWDEWDGMLRICFVRKNRTMRASWLGTKEVLAMVERNYRVYCALNSIPIDETEIGEEEDMDVDDGAAPGGGDEWGGIMDVDDEADETPSFFKEEAERVARENGGKTKSKKKKTRVAELVREKIRKVLEDVTELAERRAGKCDENDFLRLLSAFNEEGIHFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYS9</accession>
    <name>A0A3D8SYS9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYS9"/>
    <dbReference type="OrthoDB" id="21499at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="529"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="566"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="604" mass="65862" checksum="06C8DCCD981174A6" modified="2019-01-16" version="1">MKRTGPEKRGSDPRAKSHPPSFEHDEDGFELQSLSPGPQPQPQYHPSNPFAILSSFPRNIVSSPSGILVASASRSAKKTLSPTVRAHVVPPTSRYTTTSPSSYAPLPPSNPFASSIQGQAPISPSYKQFHPSNPFAALVKAEASFPTAGTIDSNQVSLEAPFDHHRPADRHRPVDQVRPFDDYRQADHLRPIDPHQAMGNNGRVDYNNLFESQNYHAISKPPITPDSSQAQASTPRPPTPFEKEGSSSKSYHTPSRREQFRERYNVEGFHLPLSPPAPAHLRGATPTTMGGDSLYELNEFNPSNENLAQDTMSTPIIPPEGTNQPKKPKKAKKVKKKKKKKKKKKLTKEDMATFGKMTSGLNLEETNFAGQKLSTLEHDDLARLLLSKAIAVKTETTVTYEDAPDAGQERNAELGVVPNEWDLPTVSQNFGSTTTVEVGGRTFTIDSGSALVDMLPLPGDGPLDKGKKEVEGIQASLRAYIEAEASKHQIPDSDGVARIKEDLAGAHLPMVAFESEPTKFWKLRRKRNNVKKKRGGKKKKLGAASTEPGVHSSALEPSRAARELVLEGEGEGEEEDGEGTLVGEEPPEDAETEEMAGRLSGITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZN8</accession>
    <name>A0A3D8SZN8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_02874</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZN8"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="55"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW91709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="325" mass="36588" checksum="9AA9F7BC2661A634" modified="2019-01-16" version="1">MTSTTDTTNFFKSAEYDEDYWNSYLAARPHYDKSFYNSIYNYHRVHRGLMETAHDVGTGPGQVAAELAVHFKGVVASDINASHLAVASHRLDSLVSSQVVKLAQSTAETLTNIHAECSVDLITAAECLPLIDAEKAVQAFSTILRPNGTLAIWFYGRPIFAEADAARRCQPLLESILDMVYSTTVNGGGPQRKEAWKRATDRMASFLDDIELKDDTWQHVERRKWNSEYAMPFYGSDACDFEITLSSKIGPGEKEVKYKDLQFWERQWDLAGVRRFVQALLPAFDRNNNDDVVEGKYKELEEAMGGEGAVRKITWPVVLILASKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0I1</accession>
    <name>A0A3D8T0I1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_01325</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0I1"/>
    <dbReference type="OrthoDB" id="30343at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040107">
        <property type="entry name" value="Snu23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986:SF1">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="101"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="169"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW91931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="235" mass="27245" checksum="B938D41E2A737903" modified="2019-01-16" version="1">MASKKGAYETTASDTDFRKKYDREEYAQRAKEREAKEREENKARYEAKLAGKKYYKPLTGDETLTQARASRLDVSQNVGKVTLMPAGAATGKRGRGAGFYCADCDLTFKDNLQWVEHENSMQHLRAIGQTGEVKRATADDVHERILQIWERLEEEKKQDVKTLGERLEVRKEEEDREREERRQKRLAVAERKRLEKEAELKVKQEYGEDVRVEGEHDEDDMMAMMGMKGFGSSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0S0</accession>
    <name>A0A3D8T0S0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NOT2/NOT3/NOT5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_01514</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0S0"/>
    <dbReference type="OrthoDB" id="258627at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="5">
        <location>
            <begin position="336"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="195"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="238"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="122"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="195"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW92120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="464" mass="50391" checksum="D0AFCD9C18AEC10A" modified="2019-01-16" version="1">MPMGSAGLPNPRPNNGPMASFAQAMGGSSQPATPLDLTEFPSLSNHPTQQSHTANQSTWATAGSRGLGPISNTRLQHANLNPQQLSSHSQGQQQQDDLFRSSSQVPGNQSGFRFGNQNAVGQSSQTQPTTTEEFPPLGRNGAVELQNAGFGGQGNSLAFGSTNIAQSNRSNGLLDALSGNSRLAPVHRVTSPASISGISASRSPVDTSRQGLGSGPDDIAAFPNGQFSLANPLISRDESIGSASGGPLQTEGQSQKRGSLTQRSTALDDSVEASQDGGESAPDAQDPLAGMSDMDRWGLKGITYMMNNYPDYAAVVAGTEFNSMGFDLEEREPISSQIYSLFDNELARPTVPSFTNPECYRVHNVASVDSKMPNFNDESLLFMFYNNPNDIQQVMAAQELNNRNWRFHKKLQLWLTKDLDMQPQQLSGDTERGYYVFFDWKLWQRERRELTLKYSDLETLTNVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T138</accession>
    <name>A0A3D8T138_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_01670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T138"/>
    <dbReference type="OrthoDB" id="3539644at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW92276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="439" mass="47062" checksum="5680A52D80102F40" modified="2019-01-16" version="1">MAAVTLCSWATVRQDHTAYEIYSGEQLKIEQIVRKSGGSGGFLASKSVQTFGQVNVRRLPDDEPEKSKGYITFDIWVSDERIDYEIEMDRQTQSLRVVTPTILEVRGLGRVYLSIEVNVWLPINTTFQLLDISTDQFKILVQDDVHVDIAHTKLSAISASIDFAHSRTAFSESDEKSISANPTSSTFKSLDTEITTNSGSIKGLLNLYNSVKITSSSGAVSVAVIPQDQSQVTSQSAQLSIKTKSGSIRGQLPIYNRSAIPSRDYQTTIESSSGSVKGSYILGSLGVFNNGSGGLQTSILPVLQSRAEGKSGLTTNGASGSSHVNILAPLHYSGHAGNEKGSGTSVGGAIRTLSSKHSSNSGSMKVFYPVEWEGVIRYSGGSGGLRVGGEGVDIQPHDKESSSRQRIAFKGENPEEGSEMVVNGKSGAVEVRIRSQRGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T142</accession>
    <name>A0A3D8T142_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transcription factor TFIIIC triple barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_01613</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T142"/>
    <dbReference type="OrthoDB" id="1877767at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.4370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019481">
        <property type="entry name" value="TFIIIC_triple_barrel"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10419">
        <property type="entry name" value="TFIIIC_sub6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIIIC triple barrel" evidence="2">
        <location>
            <begin position="45"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="410"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW92219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="446" mass="49592" checksum="5ED4987CDB914A2F" modified="2019-01-16" version="1">MAYANLPSFAIPIDPALDGSPSSAIPTPRRVEEATEEWEYEYSTTETETYYVTLDLTTPAIAQQKKTQQNRGGGTGKVQWVMPPALQAARSNKSKLPEAEQVQESTPVPGTDGGQLQKAADRVGEVQILDLDTEHPVVSFGGIVYSCRWEENIGTELLFKEHNPNDPLPVLRNLPEGVDLLAASSARIVSEQIRLDRKARSPSPEPQKGSDARILPGANLASKTRIPIGQNASEQRKDQARFLERMIELKRKKGEEDAVTVVAGKRKTRNQWLKVLSEERKKERTKLQKATKRGGKTAEKARERLDVMDEEDEEKRTEAALKDAARGREKRIIGRPKKQTLEDAERLPTLFEQQQHSFGVSSAMGSVEGSQYGGTATMPTPQQWSDGEDDDDDAHLGMGMGMENAYDQQMYGEDDGDASYQAGHNKMYDIDAPGEDDDTQMQYGWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T159</accession>
    <name>A0A3D8T159_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_01699</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T159"/>
    <dbReference type="OrthoDB" id="18472at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21776">
        <property type="entry name" value="MobB_Sid2p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05600">
        <property type="entry name" value="STKc_Sid2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000141">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000319">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000109">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017892">
        <property type="entry name" value="Pkinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF417">
        <property type="entry name" value="CELL CYCLE PROTEIN KINASE DBF2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00433">
        <property type="entry name" value="Pkinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="274"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="578"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="118"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="649"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="45"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="652"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="303"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW92305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="676" mass="76600" checksum="7A6E44228C0983B3" modified="2019-01-16" version="1">MSSFLTNLFPQPQGGKHDDILPVPPPPLHTRMSQQESFAERPGTPNRNSFITPVQTPQGSPSKKQNPPGAFDLPAAYENSMKLSPASLDTPTKSGRGSPLSPGKSNALAVDESYFASGGDDSVLHKSAGTPGSPLRKYGKENTPPTGRQALDLASKNSAANIRQELYQPRDQTPPSTTRKYNTHRGLTAEELEILNKPNVKRLANVTQLYFLDYYFDLLTYVGARQNRLNHFKSEYPAPPATPEDTYNETWKKYAGRERANLRKRRVRLRQGDFQILTQVGQGGYGQVFLAQKKDTREVCALKVMSKKLLFKLDEVRHVLTERDILTNAKSEWLVRLLYSFQDEKSIYLAMEYVPGGDFRTLLNNTGVLANRHARFYIAEMFCSVDALHQLGYIHRDLKPENFLIDSTGHVKLTDFGLAAGFLAPGKIESMRVKLEKVGETYVPFGKPMDQRTIAERREGYRSMRDKDVNYAKSIVGSPDYMAPEVLKGEHYDFTVDYWSLGCMLFEALTGFPPFAGATVDETWKNLKHWREVLQRPTWEDPNYFISNRTWGFITSCIASKTRRFGSIKEVYEHAYFAEVDWTTLRAQRAPFVPELDSETDAGYFDDFSNEADMAKYKEVHDKQNALEQMADREDPMSKSLFVGFTFRHRKPTPEDGEKSSPRKAIATDGTFGTML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1E6</accession>
    <name>A0A3D8T1E6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_01222</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1E6"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW91828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="158" mass="18157" checksum="FEE3912EBBA90C85" modified="2019-01-16" version="1">MVFRRDRTNFCFEGRSILQAANTSSRPRHVASKSMNWAWQPFSEDSGERIYARTKPLSYQWQGVLEHALMNSEDEALYRRVHVLPYQGDVIDGYVAAGKELGRSFVQYINRNQEAGMDLDALAEDTEAVVEEFEEMRENGINPSSHVAIRSTMNSPWH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T278</accession>
    <name>A0A3D8T278_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Choline transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_02067</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T278"/>
    <dbReference type="OrthoDB" id="2417308at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF20">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="175"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="485"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW92673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="60184" checksum="8D6BA1B74F632F78" modified="2019-01-16" version="1">MRDVEGHGGSSADAIEVIDHDLIATAQCEKDAKELIARTGYKQVMKRRWTRWGLLGIVQAMAATWTTQSGALQLGIYEGGPSAIIYGFILMTIGNGIVALSLAELVSAWPTSGGAYYWIGQLGGPKYGRFLSWVVGYFNTFSWIVVMASVCAFLASQLMGCVLLYDETYDVPRWTLYIIYMAALIGPAVYAIFLNKTLPYISRFMLYYLCVACVVSILMIVIVSRGNYATNKFVWATWVNETGWSNAACFFTGLINPAFAYGLLDGTIHLCEESEDPERNIPLAILSQVGIGFVTGIGYIVAMMYSISDLDAVLNSPNPTQEVYLQSMQGGRGGAFFLQFIVLLGLWVACCDLQLTQARMTWSFSRDGGMPFSTTLSKINRRFGVPLYAQLFGDFIVLLLGFLYLFADEAFNALVGSSLVLSCLALIIPITAHLFTGRKVPTPGPFWLGKFGLVVNFLSVCWLAFQIVVYQLPYFLPVVGYIENMNWTVVVVGGIFIICIAMWFVQGRKHYTVSVTAPATFDDVLDGHVVDYPSTAAAYKESAKKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7J7</accession>
    <name>A0A3D8T7J7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="1">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_00257</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="1"/>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7J7"/>
    <dbReference type="OrthoDB" id="2248014at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02662">
        <property type="entry name" value="Peptidase_C19F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF904">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="4">
        <location>
            <begin position="48"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="477"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="223"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="483"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="506"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="536"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="584"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW94494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="669" mass="73704" checksum="C259322880D823EE" modified="2019-01-16" version="1">MPEKPLTVATYAAGASLAAITLVYVFAPTFFIDGDSNNSTSSKKKGVVGLVNPANDCFINSVLQALAGLGDLRLYLIRETHRRKLDGLRVYTELVEDPARREMARWKIEGLQRGLVTQGLKEILDALNERPLYKKTISASGFVGVLETAFRQRISRQQQDAQEFLQVVAERLCDEYHAGHRARAQAKKVAVEEANGTSHTLDGDLIERRLSELTEDAGLVASTAGSSEATQSSQTAVTLTVNESGTVGTPEQVGSKASDDDGEEGFPFEGRSESQIECLTCGFKPKATEMPFCSLTLSVPQVSSTSLNACFDGMFKTEYIEDFKCEKCRLVHALQLFEQELARSNSTEFKHATAEAIQKLQYALEHDPEHPPKSVTLPDTKVAPKRKIAKHVRLTKFPKIMAIHLSRSIFDASRSSMKNTAKVAFPERLPLGGLMYQRKYKLLSVVCHKGSHHSGHYESFRRQNMYPPYSTPNTFNPAGIYSKTPTPLPSQISTPKIGAVQRSEDTSTLSSSPEMLSPTSFSSCTSLPYPNDRPSGESSRTGRHNSTSTAKSTRPQKSTPSPTSAPRRESDTASLRSVARSARETISSKMPNSLSRSNGTRTGDSSSQAPASRTSISDVARSKRKKKTSDRWWRISDEKIKESKTSDVLGMQKEVYMLFYELEKGVDDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8B1</accession>
    <name>A0A3D8T8B1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative alcohol oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_00549</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8B1"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF119">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="269"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="227"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="571"/>
            <end position="572"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW94786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="666" mass="74178" checksum="B0B31614F0D06502" modified="2019-01-16" version="1">MTVPDEVDIIVCGGGSCGCVVAGRLANLDHNLQVLLIEGGESNLNNPWVFRPGIYPRNMKLDSKTASFYYSRPSEWLGGRKAVVPCAHILGGGSSINFMMYTRASASDYDDFQAKGWSTKELIPLMKKHETYQRACNNRDLHGFDGPIKVSFGNYTYPIMQDFLRAAESQGIPTTDDLQDLVTGHGAEHWLKWINRDTGRRSDSAHAYIHSTRSVHSNLHLQCNTKVDKIIMENGKAVGVRTVPTKPLHPSQQQSRTFRARKQIVVSGGTLSSPLILQRSGIGDPAKLQKAGVKPLVNLPGVGLNFQDHYLTFSVFRATADTDSFDDFARGDPAVQKAVFDEWNIKGTGPLATNGIEAGVKIRPTEEELKMMEKWPTPHFRSGWDSYFKNKPDKPVMHYSVIAGWFGDHMLMPPGKFFTMFHFLEYPFSRGSTHIVSPDPYEAPDFDAGFMNDERDMAPMVWSYIKSRETARRMGAYAGEVQAMHPFFAYNSPARAKDMDLKTTNDYALPGNVTAGIQHGSWSMPLDPPAKKQSDLYLNSNKQDVWHDLEYTNEDIKHIEEWVKRHVETTWHSLGTCSMAPKEGNSIVKHGVLDERLNVHGVKNLKVADLSVCPDNVGCNTYSTALLIGEKCAMLVAEDLGYSGAALEMKVPNYHAPGELSGLSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8Y3</accession>
    <name>A0A3D8T8Y3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">COP9 signalosome complex subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_00664</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family. CSN5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8Y3"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000003">
        <property type="entry name" value="COP9 signalosome complex subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040961">
        <property type="entry name" value="CSN5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18323">
        <property type="entry name" value="CSN5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0736">Signalosome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="10">
        <location>
            <begin position="38"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW94901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="325" mass="35929" checksum="235A6C79CCCF55D7" modified="2019-01-16" version="1">MQLVDEHRDALYTYSEAEQKAINAAKPWKNDPNHFKHVRISAVALLKMVMHARSGGSIEVMGLMQGKIEGDTFIVTDAFRLPVEGTETRVNAQDEANEYMVGYLEKCREQGKMENAVGWYHSHPGYGCWLSGIDVATQATQQNFQDPFLAVVIDPDRTISAGKVEIGAFRTFPENYKPADSGSGDGYQTIPLSKIEDFGAHSSRYYSLEVSHYKSSLDTHLLEQLWNKYWVQTLSQSPLFTNREYSSKQMLDLSSKISQAAGAISRAGRGPSQGYGTKGVDKDLEKVVKDSNKIAGEEMTGLMAGEIKTKLFNGLGDQPTTVAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9S9</accession>
    <name>A0A3D8T9S9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADH-ubiquinone oxidoreductase 78 kDa subunit, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BP5796_01073</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the complex I 75 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9S9"/>
    <dbReference type="OrthoDB" id="10249365at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008137">
        <property type="term" value="F:NADH dehydrogenase (ubiquinone) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042773">
        <property type="term" value="P:ATP synthesis coupled electron transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02773">
        <property type="entry name" value="MopB_Res-Cmplx1_Nad11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.740:FF:000001">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.210:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000002">
        <property type="entry name" value="NADH-ubiquinone oxidoreductase 75 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.740:FF:000033">
        <property type="entry name" value="NUAM protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006656">
        <property type="entry name" value="Mopterin_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006963">
        <property type="entry name" value="Mopterin_OxRdtase_4Fe-4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000283">
        <property type="entry name" value="NADH_UbQ_OxRdtase_75kDa_su_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054351">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ferredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010228">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019574">
        <property type="entry name" value="NADH_UbQ_OxRdtase_Gsu_4Fe4S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015405">
        <property type="entry name" value="NDUFS1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050123">
        <property type="entry name" value="Prok_molybdopt-oxidoreductase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01973">
        <property type="entry name" value="NuoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105:SF13">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 75 KDA SUBUNIT, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43105">
        <property type="entry name" value="RESPIRATORY NITRATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13510">
        <property type="entry name" value="Fer2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22151">
        <property type="entry name" value="Fer4_NDSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22117">
        <property type="entry name" value="Fer4_Nqo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00384">
        <property type="entry name" value="Molybdopterin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10588">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09326">
        <property type="entry name" value="NADH_dhqG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00929">
        <property type="entry name" value="NADH-G_4Fe-4S_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53706">
        <property type="entry name" value="Formate dehydrogenase/DMSO reductase, domains 1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51839">
        <property type="entry name" value="4FE4S_HC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51669">
        <property type="entry name" value="4FE4S_MOW_BIS_MGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00641">
        <property type="entry name" value="COMPLEX1_75K_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00642">
        <property type="entry name" value="COMPLEX1_75K_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00643">
        <property type="entry name" value="COMPLEX1_75K_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="15" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="12">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S His(Cys)3-ligated-type" evidence="14">
        <location>
            <begin position="71"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S Mo/W bis-MGD-type" evidence="13">
        <location>
            <begin position="210"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00070722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDW95310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="699" mass="76008" checksum="66EEF0B7843E343F" modified="2019-01-16" version="1">MGVDNATAGSALIQACEKAGVTVPRYCYHEKLMIAGNCRMCLVEVEKAPKPVASCAWPVQPGMVVKTNTPLAHKAREGVMEFLLANHPLDCPICDQGGECDLQDQSMRYGADRGRFHEVGGKRATEDKNIGPLIKTSMNRCIHCTRCIRFANDIAGAPEFGSTGRGNDMQIGTYLEKSLDSEMSGNVIDLCPVGALTSKPYAFRARPWELKHSESIDVLDGLGSNIRVDSRGLEVMRILPRLNDDVNEEWINDKSRFACDGLKTQRLTTPLIKKDGKFLPATWEMALNEIATAYQTIAPKGNEFKAIAGELIETESMVALKDLANKLGSENLALDQPSGSSPIAHGIDVRSNYLFNSKIWGVEEADAILIIGSNTRHEAAGLNARIRKQWMRSDLEIGVVGQPWESTFEFEHLGTDAAALKKTLAGPFGEKLQAAKRPMIIVGSGVTDHADAKAIYEMVGTFVDKNAANFMTEEWNGYNVLQRAASRAGAYEVGFTTPSTTVAETKPKFIWLLGADEFSPSDIPKDAFVVYQGHHGDRGAQIADVVLPGAAYTEKAGTYVNTEGRVQMTRAATSLPGAARTDWKIIRAASEFLGAPLPYDDVAALRDRMVEISPALASYDVVEPVALKQLSKVQLVDQNKGSKSSGGELKKVIENFYFTDVISRSSPTMARCSAAKEANNCETNFMAPGEPRPQVAYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9Z0</accession>
    <name>A0A3D8T9Z0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Chromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_01107</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="436852at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18966">
        <property type="entry name" value="chromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050974">
        <property type="entry name" value="Plant_ZF_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12506">
        <property type="entry name" value="PROTEIN PHOSPHATASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12506:SF50">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00598">
        <property type="entry name" value="CHROMO_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Chromo" evidence="10">
        <location>
            <begin position="38"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="557"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="611"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="739"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="808"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="11">
        <location>
            <begin position="852"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="557"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="611"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="739"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="808"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="852"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="165"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="267"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="914"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="970"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="190"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="211"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="936"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="975"/>
            <end position="998"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW95344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1661" mass="186334" checksum="1285E04FE315D8E8" modified="2019-01-16" version="1">MVSETSASAAGANNLEGEDDDISITDSDDDPFALDQEFDVDCILAEKDDGNRKLYLIKWTGYDELESTWEPEEHIKPTIFEEWSDTKMRILRTNEAPFDFQAFEERKLKQEIERAERHRRSRAKRKHSSLLVSPFASEGEDLDDEFEAQLDTDDDAPSVAAEEINEAPADLPGMRRTSNSTFPAVKSSKKPTSPLSPSTSSSDIPLANLRLSHTQGSSRRASISDRETSLTSYQATSRSRQERPKRNIFGFKGFDKILPTASVGASFRDGATRGATRGGGASSGKYRNVFSRQGPPMRKRKTLAQQLVDKVQSSDTAVPLRHFKKTSTLRRAVKASRNISDAAPDISALPGGLYDPSKPFEALKPEDIRKQSEIEDSLFVGQDTLPANIRRAPAASLYQPSSRDPALDDRYHKICWYWYKRGKCTKRHDASSPCRYLHERLEGVSVAAEPLGVEDRLKQLCNHGSACSWKEKCEYFHPEDTLLNTTIVSAEAVSNDVKKEDSSCQVDTGNFQAQYTKTQEITQREVIPDSVKSMGQTQESKSASSHPQDTQGRLNMICYFWSTGNCHRGNVCRYHHEHRPDLPIAPAPGSQAAYTASDYDTQDAYRKYLFDTGKLICYYFDRFGACNRGSDCKFLHENDSSIPVAPRPGDRAAWEMNSNTSLKPFGQATEQSRNTRPGSDLISKPAVINQRYDSYRPEASTVRIAAPLLSANPQQKAELEPCVSSIKHEDEAYQPSRSAKRDEICYFWWSSSRCREGDNCLFHHQSVPNMRVAQRPLGNDVRRSSSAWSPRQLQQGSRDVYQTEKSLRKTEMICYFWNNGDCKARETCKYVHESVAGMPVAPRPGSREAPAAKKKVMCKFFVFGGPANCHLGDACNFSHDPETAEDGCSVQETCRYWLQGGCYNPGCRFVHRNTSEDRPLGSKDSLTGPRDLNAVSPLNKNSFAGPTTSVSFTQDKQTRLVAEPETFLYSEGNKALQSPTKTLPQSTSRPQIQSRHSTSSIIGSQNLQILTDRRSTLPDLPSLATTTQTFETSDLHIMQRFNQARGSQKHIVFGEDPKDAVLVKFGSLDQFAGQAWATTFGNLGHITLAQSCSAQDFHFHLASLVYQVYARGVLIPSPGAVNTFNRMLGYLKNVSSGLLFPHQSCSVLIYPSRLEEWNFLADSDFHGESSQFLYLIFRPGLGSKSTPRSSRYGQENLRRPKARTEIYRSLLVSKFHQLSLSTLLPGVADIANPCFYLIFPSTARSALAFLSTWLIAKKFDCKVLTSEQPGSWDWFLSYKDTPKVVLIYESAISTLPRIPSLQKLLIDSTQPTGFWYIDASLSSDMPLGLSMKQKHTPGGMATRQILPVHGVRGGAILLTPSFLMAEPEKALIFLQWFKSAVLEAPSGFWKLVCSSQMCQYLLDLAVEKATELKQFRIDNRDDDAMDANALKKGLSHEKCSQRFELYREFSEFITSGLAHGRTTKPDLFNLGTSLTDILDLWDGFHDDKYSDSTSNIIFADPEIDPDQEKSLAAWFAAWSLNNLGQFRRFIVVGTGGTIHADRAYRFKSLSDEVGLSPEEDTVSKKLAVQHTLKGRLNYSDGKSSTFRHDNMLDDENQVSAKRRKIDDETVPKKQLVSLEVTTSWYERQMNEGKGWGHIFVDQWEKAFNYLDPRLAAYVPKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8TC47</accession>
    <name>A0A3D8TC47_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">rRNA-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_01011</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
            <location evidence="2 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the CGR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8TC47"/>
    <dbReference type="OrthoDB" id="3942380at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005579">
        <property type="entry name" value="Cgr1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03879">
        <property type="entry name" value="Cgr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW95248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="119" mass="14018" checksum="702E20154983C682" modified="2019-01-16" version="1">MSTELAAATAAPAVKDVPQGMRKNGKQWHEPKKAFRPKAGNSTYLKRQEERQAMATVKAKEREMKEEKEAERQKRIQALKEKRAAKEEKARYEKLAETMHRKRVERLKRKEKRNKMIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q4F5</accession>
    <name>A0A3D8Q4F5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_13149</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000026">
        <property type="protein sequence ID" value="RDW56508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q4F5"/>
    <dbReference type="OrthoDB" id="10499206at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017819243" evidence="1">
        <location>
            <begin position="18"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW56508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="66" mass="6658" checksum="7FCB3275B5AC656E" modified="2019-01-16" version="1">MQLSVALILAMASIAVANPLAGSSDVEAKAQVARAVCNGIGNCYDNGCGGTADHLFCKAVSFSLQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q4P2</accession>
    <name>A0A3D8Q4P2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12872</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000024">
        <property type="protein sequence ID" value="RDW56805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q4P2"/>
    <dbReference type="OrthoDB" id="2732387at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48475">
        <property type="entry name" value="RIBONUCLEASE H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48475:SF1">
        <property type="entry name" value="RNASE H TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW56805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="285" mass="32722" checksum="11A690442F48C875" modified="2019-01-16" version="1">MTNGGLSMWVPNLPTMLLADRCTAKQQTKQTPFYLNHGAEAVLPIELEIPTWRILDWDSVKTTSDLLAMRANQITRRDDDLVEAARRLQRRRTTAEDWWEAHKRTRAKKIPQGALVLLFDQTKDIDMSKKNKLRYRWKGPFRVTKSDKKGYYFLKELDGTPLEGTFVGNSIKPFYKRQDMYETDDELEDESEDEQEPESDAADDAIGQGTSNFSGGVEGILRNPDSESESENEEEDDDIGPAFRTRGSSQRKDHEERMDRKRALIPEGLQYAVVLNEALEVSKES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q4V2</accession>
    <name>A0A3D8Q4V2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12916</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000024">
        <property type="protein sequence ID" value="RDW56849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q4V2"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046536">
        <property type="entry name" value="DUF6601"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34414">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34414:SF1">
        <property type="entry name" value="SUBTILISIN-LIKE SERINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20246">
        <property type="entry name" value="DUF6601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="290"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW56849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="346" mass="39651" checksum="7CFF4BFAF48D398B" modified="2019-01-16" version="1">MAEPPFPLADQLDSSLAIASDPTTQQPYLCCNTPNKNTLPSQPRVSLDPFSIRRFLVVDLLTPDLNRLTPHLWLVSTPRSSHISALHHQAVRGRHIVLAENPQLHLVWRNNTIFIKPLPPYLLSHAFWEHVFGPRAVSPPESDFPFKGWQAACGFVRTYSHLVQYKTDFDLGQEIGLIPKNVEWDAFARFIEPFHELGDREVSPRYSYGELRLTRLNFYARIFLFPKLTFHHIDAQWGAFLGNMFPVFLFIFAVLTIILASIQVELAVQQILGVAVGAPWVDYRNFGRRLSIAILVATTCIVMFFLGILMFFFVHDTIFARNVLSQQQSNKSRPHVFEKQNKSQVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q5X4</accession>
    <name>A0A3D8Q5X4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_12881</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000024">
        <property type="protein sequence ID" value="RDW56814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q5X4"/>
    <dbReference type="OrthoDB" id="4540492at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF31">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="406"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="21"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW56814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="510" mass="55217" checksum="B893E257C0441584" modified="2019-01-16" version="1">MGVTEKFDLVPNSSFLVSVLLVAASCITACTLGFDGSMMNGLNILESYTGYFHLTTATTALNTSAVWLGGCLSGLLYGYVVDAVGRKPALLYGALFTVFAAIIQAAAQNVAMFVVARILIGIGTGASGVAGPVYLAETLPPKWRAWGLGVFYDCWYVGGLIAAGVTYGTAQMQSTWAWRLPSALQGLFSIICIVILPFIPESPRWLIYKGRNEEALQVIAQTNCDGDASSPVVLVQYKEMIDTIEFEKNSGETMSFFEIVKTPSARKRTLLAVSVAVFTMLSGNNIISYYLGTMLDNAGITNSTTQLEINVILNAWCLVIALIGTYFVDHFGRKTMAAWSTVCLIVFIFIIGGLTKAYGDTSYTPGVYGTVAAIFLFQGSYSFGWTPLSVLYPPEVLNYSIRANGLAFYTFMANGAGLLVTFAFPFALDAISWKTYMINGAWDVLELVFVLYYWVETKDKTLEEIDELLDGSKHSQAPDLEAVMAGKADLGDCIVGVEPVVEVSVEASKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q649</accession>
    <name>A0A3D8Q649_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_12746</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q649"/>
    <dbReference type="OrthoDB" id="5370478at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF19">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW57296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="236" mass="26762" checksum="E5C84259AF5940F7" modified="2019-01-16" version="1">MSTPENCPWMHTSPRKVIYEDLESWRSHQGERLRFPLNSVTIHVSLGYGEMFCYVNILYYEWILFLNREYIPFLPTSESEPQGPVDPPLLQAASPDGRWAERANELFHAAACITNILEDLEELDRPLATPFAGFCAFSIATMNIYVAAFPRMNMGRSPNADISAELHLIYIDKFRHVWKIGNGLVNWHMRGLLRNDGSKADIRQALELSLAAVKLSGVNLLGGVPEIAEVLVERLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q6I9</accession>
    <name>A0A3D8Q6I9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_12730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q6I9"/>
    <dbReference type="OrthoDB" id="10387842at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="93"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW57280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="30143" checksum="271235F76AA36305" modified="2019-01-16" version="1">MVHYEDGLEVVVRDEGLEVVSVRDEGPCVQSIEDAWTGHNEGHDRKYDVQKEDKNSKYLSISSEQTRTSHDPLQQKEEVYNSRKGRICGLSRVCFWIVLAVAATIIIAGAVGGGLGAGLSKKATGSHSLAPGTTTTATVSSVPTSITASSTTPSSTVKGSSTSTSTTSSATPYGTDIAGCPGANGTTYSSSSSTTSFLKLCNQDYHDPTNGYTINIATTDNPSSTVSLNSCIDSCVAYNADNNAVPGSGGCVAAVIVMSTSQCWLKNSTGLHVDTTGQYDIAAGCMDGYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q733</accession>
    <name>A0A3D8Q733_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12456</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q733"/>
    <dbReference type="OrthoDB" id="4862890at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017560371" evidence="1">
        <location>
            <begin position="19"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW57655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="139" mass="15051" checksum="B0D79C3C056F125D" modified="2019-01-16" version="1">MLFTKAITSALLIASSLAAPLTTENMEVARSVQMSPREYWAFAIKLRDGSTAKRETEAKVVAREYWAFAIKLRDGSPVKRATLESQCEQVDEGIYCTYTSADIEAYGTGTVLEQGCVTTDTGVSCFYPGATPADAVCSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q7E8</accession>
    <name>A0A3D8Q7E8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_12544</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q7E8"/>
    <dbReference type="OrthoDB" id="5430916at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW57743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="636" mass="70712" checksum="DB8C1DE27EEEA4FC" modified="2019-01-16" version="1">MAAPSSDLKNTDLVLSISAESVQKQIQALYNTLIEDTGEYVIPRVLEIRKPKEGGGYYKTGLVAYCECPTIDFSGDKMTKSNTAKYTTARISFKLKKNPKTGADAVINYFSEKEEGIVPEVINDYTMGWEINVGFKNIQQILQDVVNRSNVPSTASKALGQYIDSRVFTVSSLFCSFQSAQMARSFAVYDSAGNVVRGDAEEAFINGVTAWYKDHDDGTPNKNNPFILGYTISQNIPKISEVNKAAVKPPPEYFIPSSFRCSLSPRVPPPMNETDIPMPLPSRDDLCSGTINYLLRTFRPEGIAAPPPLLEGDGYFPSNPFSVMKRKATPGGLDGLMVISAATFNSWFAPHFEVAYGEVLKYVNPRYEKNYNIVDGKRHSDQTPICNRFMQGRTHKRENYTVLLRNDFAREDNGYTFRVFVKVRSNVDVAYSNLATNPDDGDDLKHAVKIVITSKNEISNSKYTREINFWGTAPEAADEEDPAGWSLSRGSLAWLNFRYEFTLRPDPANRGSLQLTLDAQSHHGSDGRIRTFERRRQGSDPEWGAWSDWESESNIQGLAEAFGGSMQSFATEMASFGSNKLTDAVAKLGETFKSSIILPAAEVFMFKGIDVDENGNLYVGVAYDTPTSEQVSRKAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q7G2</accession>
    <name>A0A3D8Q7G2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_12540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q7G2"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126:SF14">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24126">
        <property type="entry name" value="ANKYRIN REPEAT, PH AND SEC7 DOMAIN CONTAINING PROTEIN SECG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="11"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="66"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="548"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="563"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW57739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="806" mass="89033" checksum="BB691BBDAC781047" modified="2019-01-16" version="1">MATSMVIVDKDGWTPLHNAAQSSSDSAVFNVKQLIRKGADVKANDALFIIGELIQAGASVNVVDKDGRTPLHNATQASSHKAWYIIEQLIRAGADVNVVDKDGRTPLYNAVQSDSEEAKLEILLARHERFSSDGSSLWSGLRIYKECEGVLNDILTVSRVNSSDKFLAKSVSEILDECYPIYGLEILDWLRTACEQSVEIGCSSDNTASFGVESPVAQTKLHQPPQQFTRRQTDNLPVLADDSSAISPIRKTIVQGTKYCKIEGHLEADRLIWTATTTSEEFARKLTDALMWILFNLLIPIRIAGQSSSATSALPNFRKLLPQFHDATEGLEIDFNLLLELAAVDRKIDTDDGSIFFGFDTALIPLAPSESKRWHFLETPGRQIIPARVKRHFKGSRLRDKIGVDYTGTVYVGWCSDVVVKIGTENSDGISPNDISMISGACGVKEYEEAVGRSSTKDVSIFTRVGFSGSGIGATFGTKKDKKYKQGAVITKRTAKENFERVLDTADSTPCILCDESVHKSWLVSATSVLLLASLRYMKLKNCSLKSEQRDGQPQEAALPYVNSPTEKPSSSLRRNQTLLLSDDNGRTIKDIESFDMIVKEIWSEMSEGEDICCGENGRKKTKSGSILGYDISDVICARRKELKSVTVSACMKSWEPIALHEKTQIIFGSQFGQVLYCNWGSETTRCFTNNVEGTLSCLFTDLRTFYSKSHEPRLGISSLSIGDDHEWIPTGCIRSSLARHCSCCLQQVFPKKRQAETKLVKKDIRRHHQIGGTLSFASLQSMKSFAITFGNTEMVGSCLHAQGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q8A1</accession>
    <name>A0A3D8Q8A1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="17">1.1.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="20">Cytochrome b2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="19">Flavocytochrome b2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="21">L-lactate ferricytochrome c oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="26" type="ORF">BP5796_12465</name>
    </gene>
    <organism evidence="26 27">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="26 27" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="26 27">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="22">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="16">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="26">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="17"/>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q8A1"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000009">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF104">
        <property type="entry name" value="CYTOCHROME B2, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8" id="KW-0288">FMN</keyword>
    <keyword evidence="6 22" id="KW-0349">Heme</keyword>
    <keyword evidence="12 22" id="KW-0408">Iron</keyword>
    <keyword evidence="9 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="27" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="24">
        <location>
            <begin position="13"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="25">
        <location>
            <begin position="112"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="23">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="23">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00075949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00078774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00078938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="26">
        <source>
            <dbReference type="EMBL" id="RDW57664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="492" mass="53283" checksum="284C39B7308918A4" modified="2019-01-16" version="1">METSSRIPVPSTEVQKHNSSSDCWIVVHSKVYDVTDFLTEHPGGSAIILKYAGADATSAYDSVHAPGIIEDTLPPAKMIGPFDQVTSFEAQPRDSEPAQTLTISSPENDEKPPICKLISAYDFEALAAATFTPKAWAFYSSAATDLVTHTANRDFFRRLMFRPRVMRNVKDVSTRRSILGFNNEVPFFISPAAMARLAHPEGELALARGAAREGMAYCVSSNASFPLASIINAGVDDQTFFLQLYVNSDRKKSAILLQKAKELGIRAIFVTVDAHVPGKREADERIAAEAVASPVSGAVASNDKKGGGMGRLMAQYVDKTLSWDDIPWIRETSQLPIVLKGIQSAADAMKAVACGVDGIMLSNHGGRSLDTAQPSMLSLLELHQICPDIFGKVEIYVDGGVTRGADILKAIALGATAVGIGRPYLYSLAYGDEGVSHFTQILKDELETSMRLSGITDVDQAHPGLINTQDVDHLVCSTERHPYITWQPKAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QB72</accession>
    <name>A0A3D8QB72_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1446-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_12010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QB72"/>
    <dbReference type="OrthoDB" id="10265871at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056362">
        <property type="entry name" value="AtuA-like_ferredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585:SF1">
        <property type="entry name" value="DUF1446 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23544">
        <property type="entry name" value="AtuA_ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyclic terpene utilisation N-terminal" evidence="1">
        <location>
            <begin position="13"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="AtuA-like ferredoxin-fold" evidence="2">
        <location>
            <begin position="502"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW59086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="609" mass="67470" checksum="E6A55182CDDB0A61" modified="2019-01-16" version="1">MSQTLSQTEFMLFIGDPSEEMYRQATMGDVDFITGDYLAEVNIAGNAEAYANKQHPGWEATAWEGIQQTIEVIAEKKIKLAINGGALNPQGLAEITASLVKEKGLDLKVCFVSGDNLLDVLGPTMPVTLAELPPHLDGTNKEVKHSPSTLAFLEKRMKIASSNAYLGARGIVTAFEQGADIVICGRCSDASPVIAAAWYWHSWSATDYDALAGSLVAGHLIECSAYVTGGNFAGFDKYDLKDLIRPGFPIAEIEHDGSCVITKHENTGGMVNVDTVRCQLLYELQGNVYLHGDSKAYLDDVAVEQNGKDRVHVHGIRGAPPPPTTKWAIFYHGGFECQILLNAAGYATEKKWDLIEMQFRSLLGKDGLEALETIEFQRIGVPAPNPKSQNSSTTYLRVFAEAREKDSLERIMRALKNISLRHFSGFHSSLDWRTAVPRPFIAYYPSIYKQDDINERVTFIGKDGELTDSFSAGHPPKYDELEERASYDAAPVVEFSGPTRQIRLGDIALARSGDKGSNLNFGIFVQTTKQWDWLRSFMSRDQMRKLLGTDARDEYFIERVEFPKIHAVHFVIYGILGRGVSSSTRLDGFGKGFADFIRDIVVEVPEEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QEE5</accession>
    <name>A0A3D8QEE5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_11819</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QEE5"/>
    <dbReference type="OrthoDB" id="3923077at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF96">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="30"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW60213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="406" mass="45607" checksum="754E014255FF2084" modified="2019-01-16" version="1">MPLDLTENKGPQLHAVAIAFVSLAWIGALLRAYTRAVIVKHITWDDVFIAASLVSYTLYCSFILVGVKHGTGQHDADLTVDNMVTALRYWYYCEWTYVITMCFIKVAIAFLYLRVFFEKWQRRVVWITLVCIILTGFSYLLAVVLQCSPVHFIWHRYHEDPMHKGACLPVAVVLAGTYLHSAVSAMSDFTLAGLPIILLWNPRFALWKKFWIGAMMSLGAIAVVAAVIRLRYIESLVVKEDFLFDTFEVAIWSTVEPGIALFAVCLSVLRPLLARIMASKSGKCIRKIATLGVDLSPDQQNPYGTLSGGLEGDRMEFALPTPSQVHQRDADLGAATFKLFTNPIHQSRAAPQVLQSTPAQSTTTLELDHEMTNPVMFPMHIKFEGLNIPELVLNRWSKISRKATIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QFH8</accession>
    <name>A0A3D8QFH8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase F(0) complex subunit e, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_11780</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Subunit e, of the mitochondrial membrane ATP synthase complex (F(1)F(0) ATP synthase or Complex V) that produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. ATP synthase complex consist of a soluble F(1) head domain - the catalytic core - and a membrane F(1) domain - the membrane proton channel. These two domains are linked by a central stalk rotating inside the F(1) region and a stationary peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. In vivo, can only synthesize ATP although its ATP hydrolase activity can be activated artificially in vitro. Part of the complex F(0) domain.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase e subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QFH8"/>
    <dbReference type="OrthoDB" id="2125027at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015078">
        <property type="term" value="F:proton transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015986">
        <property type="term" value="P:proton motive force-driven ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008386">
        <property type="entry name" value="ATP_synth_F0_esu_mt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05680">
        <property type="entry name" value="ATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="4 11" id="KW-0138">CF(0)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW60174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="93" mass="10075" checksum="5AD96D8329C13BA1" modified="2019-01-16" version="1">MASTGVNVLRYSALGAGIFYGLYHQASLSASAKLAAIDREYKHKQSLIDQAKAEYAKKNSPAETKTTGGDLITDPMDSRFDLEAYLNSLAESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QI58</accession>
    <name>A0A3D8QI58_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 12">Adenylosuccinate lyase</fullName>
            <shortName evidence="12">ASL</shortName>
            <ecNumber evidence="6 12">4.3.2.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Adenylosuccinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_11270</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>(2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + fumarate</text>
            <dbReference type="Rhea" id="RHEA:23920"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:58443"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>N(6)-(1,2-dicarboxyethyl)-AMP = fumarate + AMP</text>
            <dbReference type="Rhea" id="RHEA:16853"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:57567"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="4.3.2.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Purine metabolism; AMP biosynthesis via de novo pathway; AMP from IMP: step 2/2.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.2" evidence="6 12"/>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QI58"/>
    <dbReference type="OrthoDB" id="406045at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00132"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00075">
        <property type="reaction ID" value="UER00336"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070626">
        <property type="term" value="F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004018">
        <property type="term" value="F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044208">
        <property type="term" value="P:'de novo' AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03302">
        <property type="entry name" value="Adenylsuccinate_lyase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.275.60:FF:000001">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.40.30:FF:000005">
        <property type="entry name" value="Adenylosuccinate lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.275.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.40.30">
        <property type="entry name" value="Fumarase/aspartase (C-terminal domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.200.10">
        <property type="entry name" value="Fumarase/aspartase (Central domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019468">
        <property type="entry name" value="AdenyloSucc_lyase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020557">
        <property type="entry name" value="Fumarate_lyase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000362">
        <property type="entry name" value="Fumarate_lyase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022761">
        <property type="entry name" value="Fumarate_lyase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008948">
        <property type="entry name" value="L-Aspartase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004769">
        <property type="entry name" value="Pur_lyase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00928">
        <property type="entry name" value="purB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43172:SF1">
        <property type="entry name" value="ADENYLOSUCCINATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10397">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00206">
        <property type="entry name" value="Lyase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00149">
        <property type="entry name" value="FUMRATELYASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00998">
        <property type="entry name" value="ADSL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48557">
        <property type="entry name" value="L-aspartase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00163">
        <property type="entry name" value="FUMARATE_LYASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 12" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Adenylosuccinate lyase C-terminal" evidence="13">
        <location>
            <begin position="374"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00017058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW61378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="485" mass="54759" checksum="7B93F71F48D773E5" modified="2019-01-16" version="1">MSGNDTYQTPLASRYASTQMKTIFSARTRASTWRQCWVWLAEAEKELGLDISDEAISQMKANITMTDKDFEVAAVEEKKRRHDVMEAHVHAFGQVAPAAAGIIHWGATSCYVTDNADLIFLRDGLDLLLPKLAVIIHKLAKFAIEYRSMPTLGFTHYQPAQLITVGRRAAQWAQDLLMDLEDITKTREDLRYRGAQGTTGTQASFMEIFHGDGAKIDKLNELLCEKAGFPSCYSISTQTYTRKVDLRVANALAAFGATVQRITGDIRHLASQKEIEEPFEKDQIGSSAMAYKRNPMRCERIAGLGRHLANLNKDASDTYAQQWFERTLDDSAIRRIYIPEMFLSADAICMTLDNVVSGLVVYPNKIHSRLMEELPFMATENIIMKLVSLGESRQDAHEEIRVLSHQASDVVKKEGKNNDLIERIKKTEFFKPVWGEVDGLLDPVNFIGRCPEQVLKYCGENGEIQEALKPYKKYIEESEDVELTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QII2</accession>
    <name>A0A3D8QII2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_11535</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QII2"/>
    <dbReference type="OrthoDB" id="9992527at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="11"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW61643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="351" mass="38053" checksum="DCFF3FBC3913FECA" modified="2019-01-16" version="1">MPTKTTAIVQRNEPQPTLVQETIDLPDLTPTQVLVKVENSSLNPTDVQSFDGDAFGDGAVLGCDFAGTVEEVGSDVSRLKKGDKIAALIWGGEIPGLGAYSKYCVAEEDVAFKIPAGLDFASASTVPLATNTAWLALFSKDCLNIPKETNKDMSLLVWGGSSTVGSYAIQLAALHGFNIVTTCSPRNMEMAKKNGATHAFDYNDPDVVAKIMKAVPDLAYGFDCIGNATSSTLCGQAIREKKGVICTVRPGKANTENVPSHIDIKDVLVFTAFLKPHVYQKVYHWDTSYEDHALSKELYENIPSLIENGKLVPQRPRSMGTLSVETLTEAMQLIRDKKVSNEKLCFQVANM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QIN5</accession>
    <name>A0A3D8QIN5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding Rossmann-fold containing protein-9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_11463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QIN5"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009688">
        <property type="term" value="P:abscisic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF45">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G09150)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW61571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="251" mass="26347" checksum="1C913255E52E5F1E" modified="2019-01-16" version="1">MSNNLQGKVIALTGGASGLGLAGSKMLAARGAKVSIADMQEGALQEAVKDIEAAGGIAMGTVVDVRDRKQVEDWISRTVEKYGKLDGAVNLAGVIGKQIGLANIEDIEDDDWKFIMDINLNGILNCMRAEIKAINDKGSIVNASSIAGIIGMEKNGAYIASKHAVIGLTRASAKELGPRGIRVNAIAPGPIDTPMVRKSKDTAKETDFRNIPLGREGEASEVAELLAWLLCDGSSYITGTVQSIDGGWACH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQ40</accession>
    <name>A0A3D8QQ40_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1446-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_10399</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW63897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQ40"/>
    <dbReference type="OrthoDB" id="10265871at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056362">
        <property type="entry name" value="AtuA-like_ferredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585:SF2">
        <property type="entry name" value="DUF1446 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11420)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23544">
        <property type="entry name" value="AtuA_ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyclic terpene utilisation N-terminal" evidence="1">
        <location>
            <begin position="52"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="AtuA-like ferredoxin-fold" evidence="2">
        <location>
            <begin position="560"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW63897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="672" mass="75038" checksum="D6A8A22CFB125F84" modified="2019-01-16" version="1">MAASDPADLRAEKPPRWKYGKQSWELDVVDNAPHGVQKLRGFKMTPALQRPVRVAGASGGFSDRVRAISSLAANEDVDVIVGDWLSEMTMTIHGTGKIQKQAQLTGKALTFDEQVENAMFAENFMDCFMPAIDDLARRKIKLAVNAGASDCEILAKLVQKKVKERGHDLKVAWIEGDEVTGTVKSMLNKGEGFRSIMHNKSVQEWGLEPVCAQCYLGGLGIARALTEGADIVICGRVSDASPIIGAAAWWHQWKADQFDQLAGSLIIGHLLECAAYVSGGYSADFKDLLKQGKHINLGFPIAAIDYNGHAIMSKEKNTGGCITVNSVTSQLLYEIQGPQYYNCDVTAQLEDIKIEQVGEDQVKISGVKGLPPPPTTKVGITGFAGWQAEYHVYFVGLDIEEKCRWTEEQIKYELGDEILKKFTTLKFMQNGSSIIDARNQDVATVDFRIFAQTKDRDLLKMRNPEGFFRRSMVTFLQSCPGASLGNDMRQAEGKPYYEYHPALLPQEQLQQRVHLLFDTPEPIIDMPLAPEFRTYNRQQPSYETKNPVDLASFGPTVQLPLGKIVLGRSGDKCSDANVGFFVRHDDEWDWLRSFLTIDRIRELLGPEESPKSLSIDRFEMPNIRAVHFLLHDHLDRGYDACSTYDTLGKNVCEYLRARTVDLPEKFVARGTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQS1</accession>
    <name>A0A3D8QQS1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_10563</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQS1"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW64061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="79" mass="8159" checksum="A8CD07B9C4512778" modified="2019-01-16" version="1">MSRYLAGDYEAAAARSFGPPASPSLIALQAVLCTTSVTSQLKSYAVSTPVGRCRVPIAEAGGGTWHLDSEGNVFLGLCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QR09</accession>
    <name>A0A3D8QR09_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein HGH1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_10582</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HGH1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QR09"/>
    <dbReference type="OrthoDB" id="338814at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039717">
        <property type="entry name" value="Hgh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007206">
        <property type="entry name" value="Protein_HGH1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007205">
        <property type="entry name" value="Protein_HGH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387:SF9">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04063">
        <property type="entry name" value="DUF383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04064">
        <property type="entry name" value="DUF384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein HGH1 N-terminal" evidence="4">
        <location>
            <begin position="94"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HGH1 C-terminal" evidence="5">
        <location>
            <begin position="283"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="335"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="372"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW64080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="389" mass="44291" checksum="BD1442C27DB70094" modified="2019-01-16" version="1">MPTELEELVDFISHGNTQVRQLAVENLVPYSLSQPAIFKTNELLPIKDLKLLVRDYKQIAKEAITILINLSTDRDVLEDLASDEEFINTLLSRVTSPTEPNANLLAMLLANLAKWDDLKKIFSLERPAPEELGSSTKAIDQLLDLFVKGADGTYNKEANYDYLSYLFADLAKYEEGRKYFVTKQSYDDAVPLTKLTVFTEHKSDIRRKGVASTIKNVAFEIPAHPAFLSEDEINIMPYLLLPITGSEEFDEEETMDMLPDLQLLPPDKERDSDPTIIQTHVETLMLLTTTREGRDLMRTIRVYPIIRELHMHVDHDEVREVCERFVQVLMRDEEGEEKVEGDMKALVPRPSTSTKAFARVPNSQPGNWASQEESDNGDDDDDDDKIVEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QR76</accession>
    <name>A0A3D8QR76_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7730 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_10713</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QR76"/>
    <dbReference type="OrthoDB" id="5272396at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056632">
        <property type="entry name" value="DUF7730"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24864">
        <property type="entry name" value="DUF7730"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7730" evidence="2">
        <location>
            <begin position="4"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="166"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW64211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="254" mass="29795" checksum="F98843E744ACA298" modified="2019-01-16" version="1">MRTSLLDIPRELRDKIYEYVLLSPTGFIEPNEVSRLERFPSAIPSSTTSTTHRFVLNILHPQDRYNIENAQTYITTSILRTNRQIYQESKELFWRRNTFYFRSAVTLGWTLKAMGQAPSRLIKAIRLHETQAITPRNMKAVAKALRLLASRARHGDFRKLDLSFSAHRMEALVRNRESNNAKLQEEYDEFLRMFREASTGCKYERSVEASMWDLDGSLRLASQWENVIRDVHFAYGGRFYWDGVLLWDNYVAVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QU90</accession>
    <name>A0A3D8QU90_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_10105</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QU90"/>
    <dbReference type="OrthoDB" id="410920at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000640">
        <property type="entry name" value="Serine/threonine-protein kinase PRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF84">
        <property type="entry name" value="TESTIS SPECIFIC SERINE KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="368"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="119"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="254"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="286"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW65413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="714" mass="77641" checksum="8EF0C8A16B19D0DE" modified="2019-01-16" version="1">MSTALPQAPASQRQNCNGVTSSDHASVATRNSSTFLQNSDKSVPLPFQTPTQPPANSIATFKTNTIAPSPSPSSSPASKSAEDISRLDTASRQLTYEQPSPLSAGLRIQTDIIPNYTITAASTTRSPTDSRKPAKAPLSRTPSVKNVLASSVGSTSNFGSAPSSALSSPMLSAMADVTPLPSPLLSGDSPGPWKKLTSNSRPASRDIMISADAALVTANGESISSAIANQSKRRAYHGIANDSSLISTAINKEKAAEGHSRNRSLSEYTPGAVQVPKVRHVTVSGSHAPDSTPDSSASSDSHMRREPNLAAQRGLAAIPGPPTPPSSRAGGESSDSDSSLPLVARSSKKSRHEYFEAYTRDDHKKRRWRAVKLLGQGTFSKVMLATSQRPEDDRIDENHVFGQRTDGVLTTPEARIDPKKLVAIKICEHGPKGGASEERVEMSLKRELEIMKTIHHPSLVHLKAWSIEETRAILVLSYCPGGDLFEVASEHREILVPSLLRRMFSELVGAVRYLHERHIVHRDIKLENVLVNLPPSELARTQDWAAYPYSIITLTDLGLSRRVADDEKLTTRCGSDDYAAPEVIMGQPYDGRATDAWSIGVLLYALLESRLPFDPVSGGNEGFKQRSKTSHRIARVEWRWVEYAGEEGDHEGDPEKFERVGLLGAMHVTEGLLKRARSRWTLEKVMEEEWVKGAICVEGGIKFREEIVPDEVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUM9</accession>
    <name>A0A3D8QUM9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_10167</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUM9"/>
    <dbReference type="OrthoDB" id="10394510at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW65475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="134" mass="15420" checksum="9C682BFFFC702767" modified="2019-01-16" version="1">MCNYRSTYHPFCGHTTNPILFQTCEEEVKAMVKGKAKAICSLEDAKYLFCVTSARGACDACEQKWQVQGFVSADPDPEAVERRRKFELKQPPKRELTPLEKMKVMRREAFADWTARFNSSHRGDWVIRNGPAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QXZ7</accession>
    <name>A0A3D8QXZ7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">O-methyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_09415</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QXZ7"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF16">
        <property type="entry name" value="O-METHYLTRANSFERASE ELCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="305"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW66666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="486" mass="53469" checksum="61FFC247DC2D2B69" modified="2019-01-16" version="1">MAKLNLGGLRMSLILRSSPSRAFAPITRRQSTAATAVKQQYAESSAAQGSAEQQQPSLVELAATIKQETEKLDRYLKENGLAHPGSDVNSPVNFPKLPEEMMKARETVIQATKELGDLFTGPTEGIRWMALDHNNALSLQALYDYNIAKSFPLDGTASYSTIAKAVGLDEVNVRRFMRHAMTNRIFKEVSPGIVAHTIKSRVLAEDQAMADWIGFCVEDIMPAGSRVIQALRAHPEASEPTRTGFCVANDTVDQEPMFVTFGKDPVRAKRMGGAMASLTGGEGYEISYLVDNYDWQSVDSVPGGGLVVDIGGSHGFVCVDLAKRFKNMRFVVQDLPKTVASAPDVGALSDRISFQAHDFHQLQPVQGADVYLYRWIFHNHSTPYAVNMLRQLIPALKRGSRIVINDYCLLPPNTTSAPSAEEKIMRIMDLVMLTLLNAQERTEEEFRRLFAEASPGFVFKGVTRPAGCRMSIVEAVWEGEDAHAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYG3</accession>
    <name>A0A3D8QYG3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">cAMP-dependent protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_09585</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.11" evidence="1"/>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYG3"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000210">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF37">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="339"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="12">
        <location>
            <begin position="622"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="64"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="157"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="373"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW66836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="679" mass="75495" checksum="45BBFD2DE74FF76A" modified="2019-01-16" version="1">MASSPHGGGTLLSSEKTGAHNLAGAGAARHSFPPSGSAEKEQQLNLFGLRPAIAVATRWSASRGFPRHTTAERTRAKKGCGSRKGRSDDTGGHSSRVPSLSEMVQAGAGAGRKRTVPSSAASTLPQFLVIVARYRYCFRARHLGQAVHKVNRPDAGCDITSHEGGQAHGRSETNPTSPKTPPKPATRRCSGRDPKLDMFLPSLPFSSHLLSLPTRIGNQNTAEDSPPTVLIPPLPFLFSRFQVPVFDRAVHHRRATDDPDFWFPGNASDPLISHSAAILSPSLSTTFSLSSTMTNGATRQRARTFLAHINTHDQKPHAPQNPLHKELGCAGKCLQLSDFELIKTLGTGTFARVWLVRLAHPQEDDRDKVFALKVLRKVEVIKLKQVDHVNSERSVLDDVAGHPFITTLITSFSDHDSLYMLLEYCPGGEVFSYLRKAKRFDEPTAKFYAAEIVLILEFLHEQEGIAYRDLKPENLLLDAEGHIKLVDFGFAKRLGTRKPSKPKKAVETCIDRNQGETYTLCGTPEYLAPEVIQSKGHTTAVDWWALGILIYEFLTGYPPFWNSNPMEIYKQIVNKPVTFPSEPHISDEAKDIILQLCTVDRTFRLGNMKGGAQRVKDHPFFNGVNWEDVYNRKSKGPILPPLKHHADTSCFEYYPPEKEGREQYSSELQKKWDSYFADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R2I0</accession>
    <name>A0A3D8R2I0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Calcium uniporter protein, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BP5796_08919</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Highly selective calcium channel localized to the inner mitochondrial membrane, which mediates calcium uptake into the mitochondrial matrix. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates ATP production, cytoplasmic calcium signals and activation of cell death pathways. Sufficient to operate as a pore-forming channel without the need of calcium-sensor or auxiliary subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Ca(2+)(in) = Ca(2+)(out)</text>
            <dbReference type="Rhea" id="RHEA:29671"/>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Homotetramer, assembles in a dimer or dimers configuration with two interfaces.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCU (TC 1.A.77) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R2I0"/>
    <dbReference type="OrthoDB" id="278338at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990246">
        <property type="term" value="C:uniplex complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015292">
        <property type="term" value="F:uniporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036444">
        <property type="term" value="P:calcium import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051560">
        <property type="term" value="P:mitochondrial calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006769">
        <property type="entry name" value="MCU_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039055">
        <property type="entry name" value="MCU_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13462:SF10">
        <property type="entry name" value="CALCIUM UNIPORTER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04678">
        <property type="entry name" value="MCU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="351"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="384"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium uniporter protein C-terminal" evidence="20">
        <location>
            <begin position="316"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="233"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="461"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="190"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="206"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="465"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="489"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="504"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00036634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RDW68262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="518" mass="59084" checksum="6DE34D83E75567A0" modified="2019-01-16" version="1">MATLRSVTRALPRGFISASTARLPPPTVQTFRSRPVASSAFSAPNTRFLHVTKLRMKETRAGQAEELDQKCQDEQEQESNLDEQIGQAKELQTRTPWHREGSDKPPVKRMRRAGAMTKGKLLTTPSRLLKLILPLTTLDKNSDRKDIEPLALLVHPQQPLSYLERLIQSELPMIKKKDGSEKNPDVYFRAEDSAQDKIKTGRDYEQDVENEEGSDEQMVDGKIVKLGKIKNDSDTSTETLESGLRGGPGEGGVESYSGKGREGTATGPENQKFVRWSSSTEIGDFIRDAARGAEFAVEIEGAPNEIRVGVPSFNDRTHYLRVRLRKASRRLANYASIKKECDMLAHRSAQWLAMGGFGLMMTWWLGTYYFTFMTDYGWDTMEPITYLAGLSTIMTGYLWFLYHNREVSYRSALNLTVSRRQNTLYASKGFDLDKWQQLIEEANSLRKEIRMIAQEYDVEWDEKQDETSEEVHNAMKEERAKRKKKSKEEDDDDDDDDDSASSDRGNKKEEKKESKKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R2J2</accession>
    <name>A0A3D8R2J2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative pirin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_08904</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="2">Binds 1 Fe cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the pirin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R2J2"/>
    <dbReference type="OrthoDB" id="198735at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02247">
        <property type="entry name" value="cupin_pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02909">
        <property type="entry name" value="cupin_pirin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012093">
        <property type="entry name" value="Pirin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008778">
        <property type="entry name" value="Pirin_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003829">
        <property type="entry name" value="Pirin_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903:SF8">
        <property type="entry name" value="PIRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13903">
        <property type="entry name" value="PIRIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02678">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05726">
        <property type="entry name" value="Pirin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006232">
        <property type="entry name" value="Pirin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pirin N-terminal" evidence="4">
        <location>
            <begin position="22"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Pirin C-terminal" evidence="5">
        <location>
            <begin position="176"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
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        <location>
            <position position="102"/>
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        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR006232-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW68247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="248" mass="27081" checksum="2D8BD6C27C1ACB72" modified="2019-01-16" version="1">MTVVRGIRKAFLAVEQSEGDGARVRRSVGTPALRNFSPFLMLDHFNVQPPAGFPDHPHRGQETITYLLSGAVDHEDFAGNAGSIEKGDLQFMTAGKGIMHAEMPRASDDGSSVTGLQLWVDLPEKLKSCEPRYRDLKGSEIPTVDTDDNKVHIKVISGQSHGVDSVQELSYTPVWMLDIEIKPGGKVVQSLPQKWNAFAYTLSGNTAFGVGADKTTIGQYHNVVFEQEGDEIVAEVSADEKENGHFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R2Q7</accession>
    <name>A0A3D8R2Q7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AGC-kinase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08895</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5408302at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="226"/>
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        </location>
    </feature>
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            <begin position="475"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
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    </feature>
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        </location>
    </feature>
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            <begin position="1046"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
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            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <end position="176"/>
        </location>
    </feature>
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            <end position="314"/>
        </location>
    </feature>
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            <end position="512"/>
        </location>
    </feature>
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        </location>
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        </location>
    </feature>
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            <end position="816"/>
        </location>
    </feature>
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            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1046"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW68238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1109" mass="119830" checksum="44543FA2598191AA" modified="2019-01-16" version="1">MFSYLRPHRRTPSSPASPIPDSSHSWGESPLHAPAISAPTNPPRTFLNHQDGSPQDRSAASAASPPPTLPPLTGLSFVGKSSCSEYNLDPVSSTHDSARSQTRDSRKEDKQPDQAPVYTRHQRIFSEGQRPASAGRAGASPFTTFEPPTSRYQDKAPLPKPAESYTYSSPTDQSRPVPTGRRPTGARLQTPPPPAAATSKFEPVQARSGKVRNLLNPMSLLARRRTSQAVTQLAPVNVPTPTGGDGGSFDPRIRGTVVHDFSAPRPRRNQSYSDIRSSDGGLPLRHYQRSPNGELGKEENASSPWSGGSHTPAFTENFEEEQYPAAGPHVRKASDLSDLPLPKPPYANGQPRTEQQPMIQEQQPPLPPQSQQPQQPARKASNRKSATDIGPPVPPKTGMELPVEKRRISIDPASTPPKTALSKSQSKKGRSRNVSEVSARELALLGLPKHMKSTSSSRFSFDMLGAAEQEKLLEDRHREKALRKNASHDGDRYEDQDEDEYDYDNMDDDDGLEERIPGVNADYDDDFEESIPGVNIDSPTDDLEEQIPVADAKINEEDLNLLDDKDNVAGFTFHQLLGSDLTSPRSPYSPVMVSTPRDSNGEVIGFAMTKESPYMNLNSPLHTGLQSTTSPGLSGSGSPSPKQDRMSGLGLQGVDTGSEAEVPINPEEEFPRPATLDDDDLYFDDGIIDEIVDGGGIEFDESVFDADDTDQYGRPLKLSHTVGTLYTPQLLKALPVEQQEPATQEASPDSAQSPMVEHIPGPLAPKPSISERMVSKGLTQDTLAAYQSALAEAAQQAAANGEFDREATPSEQEENHPSLVPDTSDFSSYEPFSPSYDDFDYDDALEDDAIIAAANAEALANDCEGFYGQEFGFYSAPAAGEAQYANGGYFGPRGAEAINRSQSGRIALREPNLTPITERSEYSNRNSLMSLHLHGSLPGGALNSPGLAQLAGMMNDEGEYGGDLSIHTLMKLRNRAWGGSQASLHSSPGSPRSPIDDTSSPISLAAPWSYNGPMTPSHRRKNSTFSLVSEESAPAAKISSLEISSAPASPTLTKSVSGSTADKGHKHSGSADSISYVQEEGKRWVLERRRTAESGELELQREVISSGTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R2Y8</accession>
    <name>A0A3D8R2Y8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Centrosomin N-terminal motif 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_08967</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R2Y8"/>
    <dbReference type="OrthoDB" id="10251744at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="120"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="219"/>
            <end position="268"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        </location>
    </feature>
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        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
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            <begin position="445"/>
            <end position="540"/>
        </location>
    </feature>
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        <location>
            <begin position="596"/>
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        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="756"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="146"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="59"/>
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        </location>
    </feature>
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        <location>
            <begin position="103"/>
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    </feature>
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            <begin position="235"/>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
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        </location>
    </feature>
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        <location>
            <begin position="636"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="666"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="694"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="705"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW68310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="841" mass="93772" checksum="F1D69F3C220ECFC4" modified="2019-01-16" version="1">MEEGLQQRRNRTYARPESSCSRDTKMTPSNSSNASTVATLPPRHTQKGRQPGGASMLQERLRERKVESARHQRQDAGLHGLDDRGIQSSPIKAIHTREERRPSSSGNGMTPSAKNMGAKHIEDQLSTLHKQNFDLKLELYHRRERQEKLEARLAAAEERLTQQDELQEVNEELLAELEKRDQAVEEAVDIICNLEAKVESLMREREIVRKFDAQESDYFQSNHQNTSPSSPPGFTPTSTEEGGSSQKTNLVGSHSRLPRMPSFFSEQSEGTEALRSLYLPVDRGHSGMSLPKLAEDTDEMNSPHSPRLSVLSESSFLSVYGEKPLALDSTDGQDDLQSSLTTRRHRTSTSIEKWIDERPRNAETPSRTSSNPRKVSGRQPPVLSIGSVLQSPLQRLERGEHRLERLRIRLEQGNQSLALRHTETLDQPAGDQEKQESKEIMRRMATDRRSFDRQQALPPTPDTVSTSTLRLFKNSNDTLHDRARQVDGNRDNYVGNGARLPSLRTVSNPQRLLPSARPRSQGESIRSRPTGHGWDTGARDDEVDSILSTASTYDNPETTLAPDFFGVGTQAGLNWARDVMFNHDSPAQLPTHRTKFYDETQRASREPPSDTPGTEDLVEQRNYEPSRVNNKPSGYAPSSPDASPRPSLPPRRASLSTGTKLRKTQRSLSYSRQNSPALDATSSPPLKEPKRSRFSGLFGRSSTSPSVNGSFNNQQIESDLNHNASPDAGNIENDTDYRRCQSQGACMITSGSLFDEDRLSSATPPPILRSRPTQAYARPSSAGAGAVRRRSILGTDYCGEEPKVRISCEEERRGAMEDANGKGGRKWFGKLSRAGSLNKRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R335</accession>
    <name>A0A3D8R335_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_08881</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R335"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF92">
        <property type="entry name" value="AGL026WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="206"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="45"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW68224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="502" mass="55612" checksum="187982C90845F9F7" modified="2019-01-16" version="1">MAAEHDKKDQLELSATNDVDVQEASSLEWTPADEKALVWKIDLRIFPMLIILFILNFIDRGNFANARLKGLEADLGLSDVEYQTCISILLVGYVLMQIPSNMILNKISRPSWYLCSCVMIWGMISACIAAVHNAGSAIACRFFLGCVEAALFPGSLYYLSRWYTRKEMQTRVTLMNAGNLLAQAFGGLIAAGVLGSMEGKSGLRAWRWLFVIEGVITVFFAFVALFVLPDYPTTTRWLSQKEVFIAEKRLVDDAGVADEDEDDMSAMKGLWLALTDPKVWLLALTYHATIMGLSFSYFFPTITSALGYGTTETLLLTAPPWIWALIVSIPNAIHTDSSGERFFHFAWPAVTCCVGFIISMASTNTGARYFSAFLMTTGYASGFAMLAWISNTIPRPRAKRAAALAFVNAWGNIGSIPGAYIWPSSYGPYYRKSFGASLAILSFAVCSAFVLRTYLKHLNKKLDSDEGVAFEASDNALKHAAELAHESAEEVSERKKAFRYLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R3P1</accession>
    <name>A0A3D8R3P1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_09304</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R3P1"/>
    <dbReference type="OrthoDB" id="3491794at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW68647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="548" mass="61080" checksum="B029AEB9CF910CB9" modified="2019-01-16" version="1">MPSDLRPVVVLQEALENVSLGDVLQLPAALQSFHKFLRRGTSQQREQLLHSSSHDLCANHPATALAFDDGNTTWPSNPPKIGQKRLLSSQHYSTRNASARKRKVVIPPHAAACSFSATTSHQSSLATIPFREADRGAKHSEPLLAEEDESAYKSILETVKVPLDTTSHGLSSQPNLLVRAREFFEARLNSRKNRAPYLVRAVQGFLEAPLLPAEFSKDMWNEKSAIFSKPQVAGSTARFRSLYEGHRKIKRCGEQYLSATRFCYIYLEHDLEQIMASQELVLSQGRGKVTAAFQLQAESISITMDTLRAERKAGRGYIRLLMEGGPGFVLRMGSNVSTIWERKLSMSDIALIIEFIKTHAVDLYDEIKSYDKAAVQGLLDGFIAYGWTRREIRETKSSLFDELQRYVDVEDTGLDVTCDEPADITSLPIPTLEPSQYTMSGETLASPVFSDLDLLLEGGDHTIPTPTNSTEVPEPVIIDHDSGYVEMTDLKIDQFLSDANYDIALDSMQCSDSTIQDDFNLFQELFPELAEHQAGSQTIGEDSVRMVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7K1</accession>
    <name>A0A3D8R7K1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_08432</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7K1"/>
    <dbReference type="OrthoDB" id="10337409at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW70035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="234" mass="25431" checksum="AA48CC1E1B248D45" modified="2019-01-16" version="1">MPYPFGPDSSDAEVTARYPCEVHECNVTCARAADAKRHHATKHGGPKTKCDLEGCTFEHPRSDKVKLHKLKKHTTPNDGTSPSTAGGSSSLETYALPYRPAAGHQTAMQTPWMPRYYPNSLLTSPVVECVCGGLQLTSPSANLYNIFTANQAGPTWSPPNTGMQNTGMAFMDTATQVQNNGYAALQSGYTAWNPFSPPWYPATSPIVLQYTPAEESAEEAENYSFGPDSMPENY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8M7</accession>
    <name>A0A3D8R8M7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ABC transporter-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_08723</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8M7"/>
    <dbReference type="OrthoDB" id="6512918at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00267">
        <property type="entry name" value="ABC_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001332">
        <property type="entry name" value="Similar to ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43158">
        <property type="entry name" value="SKFA PEPTIDE EXPORT ATP-BINDING PROTEIN SKFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43158:SF2">
        <property type="entry name" value="SKFA PEPTIDE EXPORT ATP-BINDING PROTEIN SKFE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="13"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW70326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="291" mass="32113" checksum="6B8FBAFDA383CDCC" modified="2019-01-16" version="1">MSGPIDQTLAPGIEVTKLSYSFPDSSVGLRDVILSLPPSSRTLLIGANGAGKTTLLRLLSGKRLAPSGTISVGGLDPFKDGLEGVTYLGLEWVLNPIVRTDIGVQELLRSVGGDHYPERRDELVEVLDIDLEWRMHAVSDGERRRVQLAMGLIRPWRILLLDEITVDLDLLSRSNFLGFLKQETEKRQCTIVYATHILDNLAEWPTHLVHMSLGKVKEWGSMETFDVQGKREYDSGNSRLGMLVLGWLKDDLQERGPRNSKQAVKVGSEGKSYAVAGTGGYGSEVAKPRTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8W4</accession>
    <name>A0A3D8R8W4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="5">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_08797</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cell membrane</location>
            <topology evidence="1 5">Lipid-anchor</topology>
            <topology evidence="1 5">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="5"/>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8W4"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF8">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017497145" description="1,3-beta-glucanosyltransferase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="390"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="410"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW70400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="466" mass="48504" checksum="B8CAC1748F914975" modified="2019-01-16" version="1">MISLFARAFLVLNVAIFAVAALPTISVKGAKFFAGGKQFFVQGVAYQGSPSDPLVDSTQCNADAALMKTLGTNSIRVYHVNPYVDHSACMKIFDDAGIYIWLDLDTFNTTIVQTAPAWSEEQFIAFTMVMDAFQSFDNLGGFWIGNEVISSASGSPAAPYVKAAVADMKAYLAKKNYRDIPIGYSAADIAELRPNLQNYLACGTDYSQSIDFFGLNSYEWCGDATYQTSGYNNLQAMSEGYSIPIFFSETGCNVGGARTFADQAAIFGSNMIDTWSGSIIYEWVQETNDYGLVTYPNGALVGIPTKIQPDFDNLAGQWASLAPSGVAETAYQPSFSAPACPAPTAGGWLVDGNVALPTLGVEIVAAAAASVKPTSYVLVAPSTLSSAVSSAAPNTATEASGSKTTGTLESTATKGVGSSTSSSSGSSTSGSASATSSASAAADALNSLSRGSAFAGLIFILGVMIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCU1</accession>
    <name>A0A3D8RCU1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_07886</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RCU1"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19079">
        <property type="entry name" value="AKR_EcYajO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000004">
        <property type="entry name" value="Oxidoreductase, aldo/keto reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF9">
        <property type="entry name" value="OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="38"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW71852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="357" mass="40364" checksum="725E65E7454F99BC" modified="2019-01-16" version="1">MAASPTPEMPASLKASVEASKAEYVQLGKSGLRVSVPIFGAMSIGHPAWAPWVLDEEKSLPLLKAAYDRGLNTWDTANVYSNGESEKIIGKAIKKYDIPRHKVVILTKCFSAVGEEPGLRSIFYPKELNISKDYVNQKGLSRQAIFAQVEASLARLDTPYIDLLQIHRFDKTVPIEETMEALHDLVRSGKVRYIGASSMWAVEFAQMQFVAEKHGWTKFISMQNHYNLLYREEEREMNRFCDMTGVGLIPWAPLCRGHLARPLEKFGTTTRSKPEQELSEIDNKTIGRVQELAEKKGWKMSQVALAWINKRISSPIIGFSSVDRIDEAIDVRGKTLTEDEEKYLEELYEPKTIKGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCZ6</accession>
    <name>A0A3D8RCZ6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_07967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RCZ6"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW71933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="109" mass="11856" checksum="BA58882A09BF26AA" modified="2019-01-16" version="1">MDAFGASSLPMGLAIEDFLTSFHTPSAAFPNFVYSSRDERHGRAGVSIDSRRSLHGCVRDVDIVPWSTPSEEGQIAPGQQNEEGLEDFRNGAGSGRPAQREPSDLLQHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDU3</accession>
    <name>A0A3D8RDU3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDU3"/>
    <dbReference type="OrthoDB" id="414322at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017745705" evidence="1">
        <location>
            <begin position="27"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW72088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="299" mass="33681" checksum="B88A6CD234657986" modified="2019-01-16" version="1">MAPGVLTTSSLLTIIITTSVTPSAPSTELLSLVLESFRRHCPLLLKCRVIVVFDNYDRVTPTPRLKKGCVTSEQAADYVLYKENVKELFLRQFYQDGENIVFSQIEAKAEYGSPGDAQNVVNLIALQSHDKKVIFIEPSRRLGFGLAVRSALRMTETPYTWVHQHDWVLLSDFPIDPLLEIMRASELDEKAPIKYVCLPAIRMLSYAISDAVMRFPALRELTSSLKRDLSPASRPDIKIPLTPLFFWHDKPHIASTAHYLARIFPTGLAIPRGDFIEDTIGQRARTQMKEGLHMTVEGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RE14</accession>
    <name>A0A3D8RE14_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_08192</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RE14"/>
    <dbReference type="OrthoDB" id="10399730at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="78"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW72158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="164" mass="19991" checksum="0578DA919BA3FE9A" modified="2019-01-16" version="1">MGSRHRRASSYNPSTRELLDEAEDRNARLNDELRREQYNFRAQQREMQILQDKYARLKYHHDGCRDLQAREYDYLRDIKTLKHKLREKEAMLDSLDQRHRLLKRTNCDRLRHSDVERLYTKLKESEDARAIAEIRNQNKDRAVNELRAQLARFGFRVDLHKYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RI62</accession>
    <name>A0A3D8RI62_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_07088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RI62"/>
    <dbReference type="OrthoDB" id="3946545at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="613"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="684"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="429"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW73646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="707" mass="78406" checksum="805AE09D63099AA0" modified="2019-01-16" version="1">MTTNASKSMPHLPSISTSTTLLDRVRRVAEASPKTRRSKWTEETGSENSQVLFMKPGKESKRNRRSLSTIGNNATCDITKEVEKNGTGSEYDENEDFAWKVIDREIFEWQYVCRTGRPYWWSPESKYCRLQKLQPRLFCAPSPHIWLEEMDDGANRDYKPIRRAVSDSIIADPGRVDELAQLIAVQLLGACFTIPPDFAGIPSPNYKVQDRPEFPDLFDPRMISSLRMHTHFRYSPAFGHQARSTSPVESWPNTYAGYDGTSTNITPAESGFETPDIVTSQLRRRKRGTCRALHITEGSLTSRSDGSHDRASMNSATVSDEYCVEGSKAEAESSRDIRAQQLSDPREYARENREEQEHLQASQQSKSDHRLHSILRSEPHPVYVHPVKDLVVRKWKRIRRRVGGKMAVSAADDDHSPALLAAATAFMTPHSGDASPASSSDGKERRRLAQERGEILSSSTEGTPLYNTPTSIKTPTNGETTSVLQHSHAMPAAETGSYFMEDFSREILALPVGLEGRPVQDMALSSRTSFENHMSVASAPAEDTKATMVLGSYMPQRAMTAGATSMNTPNRRSKKRRSLLSEVYNADETEVLADIIPEIEPRSILSAIGSAIPSPEEEVPTPIVTTKPPSDETGAVSQSTEFGSSREADQVLPDTEMLGLVRSNTSGTQLFKPFAESMEVEGMPIGPAEDTWDGDAGSGVRRERNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJ49</accession>
    <name>A0A3D8RJ49_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar protein sorting-associated protein 51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_07400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the Golgi-associated retrograde protein (GARP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the VPS51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJ49"/>
    <dbReference type="OrthoDB" id="203678at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990745">
        <property type="term" value="C:EARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014812">
        <property type="entry name" value="Vps51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15954:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="264"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU368010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW73958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="289" mass="31986" checksum="6F8AA5FC1604D2DF" modified="2019-01-16" version="1">MSTIAQPRDSSVNGRRIPLIATPTSSSRPSLDIPRSETGSPATNPPARRNRAALREYYNLKKVSESDEIPNSDAASELSSNDHSDVAESELDAADFNAEEYVKHALQSQSLSELLRTYNGVLTDIRALDAEKKALVYDNYSKLIAATETIRKMRMNMDPLNPMASTLDPAIASIYERAQNIKDELKSSLGEGPRQGRDATERRKARNAAKKVLETPENLRMLVAKGNTEEAKKQWETTRKLLERWLERGVGGQDVAACIEDGDAALRGEPPNEKSWVHVRERGINGGTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJ59</accession>
    <name>A0A3D8RJ59_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NACHT-NTPase and P-loop NTPases N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_07323</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJ59"/>
    <dbReference type="OrthoDB" id="195446at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW73881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="138" mass="16062" checksum="1210F2BCD32B3231" modified="2019-01-16" version="1">MMPMIQRRLSVALNVVKAKLEHKTGLEKALTSLKWPFNEKEIEKLIYEIRKCSSENKTQFTELIAAVEKSSSERDRQLSQLMQTFNTASIERKQQLIDVKAGIDGLHQAGDDQQRQTILDWLNPIDYITQQQDFISRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJ71</accession>
    <name>A0A3D8RJ71_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Oxysterol-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_07420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJ71"/>
    <dbReference type="OrthoDB" id="14833at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000007">
        <property type="entry name" value="Oxysterol binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.2720:FF:000001">
        <property type="entry name" value="Oxysterol-binding OBPalpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2720">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018494">
        <property type="entry name" value="Oxysterol-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF102">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01013">
        <property type="entry name" value="OSBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="452"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW73978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="536" mass="59918" checksum="C5C00EC9E4797166" modified="2019-01-16" version="1">MVSLTGLKDHTHRRTSGASNRSSVDEPRSAEGAEDETTVEPDQGNVLSHIISQLRPGADLSRVVLPTFILEPRSMLERITNFMAHPETLLPMPDIEDPTQRFVSVVKFYLSGWHIKPPGVKKPLNPILGETFTCYWEFPDKTKGYYISEQTSHHPPKSSYFYMAPEHHIRIDGCLKPRSKFLGNSAASMMEGIAILRFLNRGGERYILTQPNMYARGILFGKMKYELGDHSFVRSPELGLSADIEFKTKGYFGGTYNAIGGTIKNDKTGEALYELSGMWSGEMIIKDLKTGKKDVLFDAHNAKPTPPLVRPLEEQDERESQKLWRATCRAVIARDHVAATDEKTKIEDRQRDEAAKRAEEGVEWHPKLFRHVKAGPGEPEEGEENLDWILNASIDGATPEEQIKQILAVTPILPGQKQSERFAIPPPHHHEAQPVPAPVQALASHELIDLGEDTSTTLTPPNHFPDDLKAAQTQNGGQKQKAMEQNLRETSTERGSKDGLIDFHADVQKSLPKAEPSLLRQDTDTQSVDEFLDAQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJM7</accession>
    <name>A0A3D8RJM7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_07622</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJM7"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000140">
        <property type="term" value="F:acylglycerone-phosphate reductase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05374">
        <property type="entry name" value="17beta-HSD-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44169:SF6">
        <property type="entry name" value="NADPH-DEPENDENT 1-ACYLDIHYDROXYACETONE PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW74180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="284" mass="30311" checksum="A506247502534EAB" modified="2019-01-16" version="1">MASSKQKVLITGCSDGGLGAALAIAFHEAGLHVYATARNPSKMQGLAALGIETLTLDVLSDSSIAACVSQISGLDILVNNAGGMYLMPVSDLSILEAKKLFDLNVWSYLAVTQAFLPLLLKSSKATIVNQTSISSSVSVPFQAAYCASKAAIAQFSSVMRLELQPFGITVVDLKTGVVRSTFIKNTVAQHSSLPKSSIYDPAREVVEKALRQEGFSDAGMPTEQWAKAVVQDLLKKNPPPLIWRGEQAMLARIGSILPFGMLDGTTKKLTGLDIVEQKVQKEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RP91</accession>
    <name>A0A3D8RP91_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_06708</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Lipid-anchor</topology>
            <topology evidence="1 9">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RP91"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000038">
        <property type="entry name" value="1,3-beta-glucanosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012946">
        <property type="entry name" value="X8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF2">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07983">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00768">
        <property type="entry name" value="X8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 9" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017495446" description="1,3-beta-glucanosyltransferase" evidence="9">
        <location>
            <begin position="24"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="510"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="X8" evidence="11">
        <location>
            <begin position="379"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW75887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="531" mass="55697" checksum="0DE68E502EF0F610" modified="2019-01-16" version="1">MMLQNPRSIVSSLSLFVLGASAALQTVTIKGSKFFYSNGTQFFIKGVAYQQDGSATSQGYIDPLADVTSCTRDIPLLQKAGANLIRTYAIDPTADHSTCMGLLDAAGIYVISDLSEPNLSISRTSPAWNTQLYTRYTAVVDALAPYNNVIGFFAGNEVTNNVSYTEASAFVKAAVRDTKAYIKQKNYHSMGVGYAADDDATVRFDVANYFNCGDQADIIDFWGYNIYEWCGASDYQTSGYAARTAEFANYSVPVFFAEYGCNTQGGGAAGRKFTEVAALYGSQMTPVFSGGIVFEYFEEANDFGLVSISGTSASTLADYNAWSSEIASVTPSSVSSAAYTPTNTVQQDCPAVASTWLVAATGLPPTPDQTLCDCMMASLTCKASSSLKASDVGTLFGQVCAYNNGRPCAGINTNTTTGIYGAYSMCNATEQLSYAFNAYYQEQGNNAQACDFAGNAVTAKAAATAASCSSAFAQASVTGSSGTSGGGAAASSTKKSSADSLYVPKSITMGSYYLVAYMAGMGLLGGAMVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPF7</accession>
    <name>A0A3D8RPF7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Restriction of telomere capping protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_06657</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in a process influencing telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RTC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPF7"/>
    <dbReference type="OrthoDB" id="289228at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF130">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="7">
        <location>
            <begin position="327"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW75836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="600" mass="66613" checksum="2727433BF7996905" modified="2019-01-16" version="1">MGQAHSGDSQPQVTSEQLSHELALRFAKRCFTPIELYSFQDVFKSLADHQDSISYLKEDTIARFLEIPDILGVSSIVFQMVSYLGAFPFGHEAPAVLGFEQMIMVVVIMTERYQRVLKKGNRDRTKLLFRSLAVFDRKDFDDKATSVSEGTKEANGSSRSHAPGFAVDEAANDEEDDDDDDLALAALESLDAIQVFKHGDAPIAEASIPSDNLKKLIMLLLMIAPLDAQESLARHSERLSGTQLEGLRKTADHILSAFVNVEKYPGVKFHRFNSVIPTSFPFLFNGFTPLFEHFLFSKNLDFHKRKDSSTPAAQPPELEPLLVDNGEILDLNVLSQLSFFLPGSSLFRRLRLLYSGGDAGFSMGSFETKVFNWRAPTILLVSGNRISELPTGQERVFADSLPPKRFPDSSKSTHVTFGVYLSQPWRQTHKECIGDSDTLLFQLEPTHEVFHASSINKDYVSFTKPPSSHCGIAFGNPPPKPKATAGLSKHVNLGAVSLYLDASFEFGVFTHNYTSGGGAFHNSTARRQDWQDRFEVESLEVWGCGGDAEAKGQRERWAWEEREAEARRRINLGSGDIEADRALLEMAGLIGSNRSGGSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPW6</accession>
    <name>A0A3D8RPW6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Quinate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_06924</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPW6"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF34">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="21"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="283"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="24"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00043213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW76103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="540" mass="59881" checksum="1CA2026A0B797F99" modified="2019-01-16" version="1">MGLLAKVEDRPTPPAVYNWRVYTCAAIAGSAAIMIGYDSAFIGTTIALTSFKSEFGLDQLSTAKFAVISENIVSVYQAGAFFGALLAYIIGHFIGRKRGLAIFSGIFFLGAGLMLGANGSRGLGLIYAGRVLAGLGVGGASNLTPIYISEVAPPAIRGRLVGFYELSWQIGGLVGFWINYGVNTTMAPSHKQWLIPFAIQLIPAAGLFLGSFWLRESPRWLLSKNKREQALRNLSWIRHLPLDDVYIKEEVYAIDTALEEQRSTVGLGFWQPFKKVANDRKTLYRFFLGASLFFWQNGSGINAINYYSPTIFKSIGITGLNTQLFTTGLFGVVKTCLTLVWLFYLVDKWGRRNILMVGALGGSLCMWYVGGFIAVANPTAHPSSKLSSGGISAVFFFYLWTAFYTPSWNGTPWVYNSEMFDQNVRTLAQASAAANNWLWNFLISRFTPQMFVKMGYGVYFFFASLMLLSVPFVFFLLPESKSIPLEAIDRLFDRKHASPRKAHGMLLLELRAEEAALRAGLEGESLTDEKQEVLQVEDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RQD7</accession>
    <name>A0A3D8RQD7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_07001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RQD7"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF697">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="125"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="49"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW76180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="470" mass="50057" checksum="8BD42F6528EAA274" modified="2019-01-16" version="1">MSLRKISSEKYIRDAEIAAAAPIAFPVEEYDNKEREVFEKKDGVVDFRTVGWPRATGIFLKVIFATGVLSIPTAFASLGAVPGVLSVIGWGALNTYLGVILGNFRAEHPSNHSIADMAGMMGGPILKEMVGALFVIAWILGTGSGIVGIAVALNTFSNHAACTVWWCFLAAFIIAAMASVRTFHAIGWLTWTGFISIFIAVLIVVIGVTLRDRPAGAPQTGPYELGFLVIGNPTFQAGITASATIFVSSAGPVAFVPVIAEMRSPGDYKKALFSCMGFVHASYICFALVVYKWCGTWVTSPSLGSAGPTLQKVSYGVGVFGLLVSGALGLHVAAKFLFVRILRNSRHLQSNTLIHWGTWLSCTFGLCAISFILAEAVPIFNYLLALTGSLCFAPLQIALPGCLYLFQYRNTYKAGTALQKTIYYAHFLLPLLGAFMCAGGTYGVVQSIIDAYANGTVGGVFSCANDSGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RQK4</accession>
    <name>A0A3D8RQK4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peroxidase</fullName>
            <ecNumber evidence="12">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_06985</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 12">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="9 12">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="9">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the peroxidase family. Ligninase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="12"/>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RQK4"/>
    <dbReference type="OrthoDB" id="2113341at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001621">
        <property type="entry name" value="Ligninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF66">
        <property type="entry name" value="CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00462">
        <property type="entry name" value="LIGNINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 12 14" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017498213" description="Peroxidase" evidence="12">
        <location>
            <begin position="18"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="13">
        <location>
            <begin position="178"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="126"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="127"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="92"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="113"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW76164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="359" mass="38505" checksum="ADB900C64F38272E" modified="2019-01-16" version="1">MKLTTYLLCATAGTAAAYPGMNNLMAELAKRAAAAPANPTIEMIGDLVQGATTPVGKEVKDCLLGNQPCQNLTPKTYVAPKLYSLSCWQDTCCVWDYVQADLVKMFSNTDGTCNALARQAVRLGFHDAAAWSKTSGPGGADGSLVLSWDEINRSENKGMQEIRSKALGLLTKYALWGVGGADLVQFMHNVATVVCPLGPRVLTFVGRPNRFTSDPSGLIPDTHSPAPVLIDLFQNKTINFKDLIALIGAHTTAQQFFVDPSKAGQPLDSTPGVWDVKFYSETLAASPPPGVFRLPSDQSLVSDPETQPGFTVFSNPTNGQQVWNAAYSTAYVRLSLLGVNNINKLTDCTKVLPNPVTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVC7</accession>
    <name>A0A3D8RVC7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Apurinic-apyrimidinic endonuclease 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_05881</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVC7"/>
    <dbReference type="OrthoDB" id="7663182at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.150:FF:000001">
        <property type="entry name" value="Probable endonuclease 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445:SF0">
        <property type="entry name" value="APURINIC-APYRIMIDINIC ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="ENDONUCLEASE IV ENDODEOXYRIBONUCLEASE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="11" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="10">
        <location>
            <begin position="172"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="44"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="463"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="463"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW78029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="511" mass="56081" checksum="358180ED0248CBC6" modified="2019-01-16" version="1">MSRRSARGAEKLMKSETIASIAKAVAPKKGRTVKVETDEVLEVVTPAKSSTKKQLVAEDASDNNESAEELEPAKSKTIPKKKAGVKVEPQGQEGTKSEEKTTKKRKAGKGNQTEDKEDASEVKVTKKRKTKEEKEAEAAPILERTPISSLKKPYHIGAHVSGAGGVQNSINNALHIGGNSFALFLKSQRKWTSPPLAPEARDQFKAFCLEHKYDAAKHVLPHGSYLVNLAQADAEKAEQAYSCFLDDLHRCEALGIMLYNFHPGNTGPNPRPEAIARIAQQLNKAHKATKTVVTVLENMAGGANVIGSTWEDLREIIALIDDKSRVGVCIDTCHTFAAGYDLRTPESFKSVMDDFTSIVGIKYLKALHLNDSKAPFNSHRDLHANIGTGFLGLRAFHNIMNFAPFQGLPMVLETPIDKKDDKGKSIEDKGVWAAEIKLLEGLIDADPETEVFKKEEQRLQDLGAEERKKFQGQADKKNQKTIDAMFKKGKKTKTKKEDANDSDGSEGGCSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVE8</accession>
    <name>A0A3D8RVE8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_05810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW77958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVE8"/>
    <dbReference type="OrthoDB" id="3477286at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="115"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="884"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="955"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="896"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="955"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1018"/>
            <end position="1040"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW77958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1098" mass="126835" checksum="C1D3DA57F9C25AB1" modified="2019-01-16" version="1">MATFQSQPAMKSLTEHVSAAAPDGFRWALIPEEPAAVDRRRGEIIKFDDPKSKNIKEFRYERLSNMRKRIRLLELMAGKRETSEVECQLFEGEIKNGRVYRRKSDKDENEIEVKFEALSWSWGAELPEYQILIRRGGKRQRKKASKDLVWALRYLRYQDKDRILWIDAICIDQQNVDEKNHQVQMMSQIYGYADRVCVWLGLDDKESNMAINFIKKEILQLEQFDELCTNESNSEKWQSLLLLMQRQWFFRRWVVQEIALANDAMIYCGPDQISWKDFSVAVELFVEVETATHRLSEVMKKDPRFYHVPGWFEFVSALGASLLVEATGMIFRYYKPEKNEASNKLVNGSGVSGENENKRQVEATNSRLVSHDTEQVADGERQQRVEELTEDEETDQSEVEYQTDIGNDEDSEVDGDDQVESNVGRNAESAAKKKLKAPNESVSDDPISQRRPLLSLEYLVSKLSIFEATEPRDAIYSLLAIANDGYPHAEGHGDELSPSTQEILSESSEQKPFPVNYGAPYADVCQTFIEFCIARSNKSRALDIICRPWAPDPKSGTSIHFNQKPKSPDMKAWLKTLEELHKDPEEFKHSKAWELMMKYFPDPKSRQRKTRLPSWIPRLNGAPFAMFPHAGIHIMKMGRKNADPLVGLPYISRSYDAAQGREVDQEALRFRKRRAQNAHCMFVKGFILEEVDKTTNSSQSGSIPKEWLKLGGWKILKDPKKDKGPPEEFWRTIVADRGKDGQNPPYYYSRACKESVYKGGLASGAVNTSDLINNERNSIVAQFCRRVQSVIWNRSLIKTDQGNLGIANKNVRKGDLVCILYGCSVPVILRPRKKEKDIIREEKEEDQRFGKMENILRRYMRRAKAIKVRKEKWMKRSDTEKADVRKELEHYKGKNARSQETTSDQNSSTTFLPNYQQQVKIQDNVYYTFLGECYIHGMMDGEAMRRKIKYESSKNEDWLKKKEAEKKRTEEMKSETQRVENNDPEGMVAEMAGQETTELPQKEEEEEEIYNEPEGEPLAEKENLMGHSEGSVHEKGHVEVDTSPPSDEEDGEQIGNQFEKETSESEEANNQKLTAATLVENWDTWRGPLLRDTIFELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVS2</accession>
    <name>A0A3D8RVS2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_05940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVS2"/>
    <dbReference type="OrthoDB" id="1305878at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16449">
        <property type="entry name" value="RING-HC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="218"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="39"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW78088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="280" mass="32023" checksum="9D13994381A5D2F4" modified="2019-01-16" version="1">MSFPNPFTNGASPYLLALEHDVPVQPWEIEMFENTDPASNPTRDFQHQRHLPRTLPQGQGRRNHSALRAPPRSYATARKTTAQNSHSHNFTHPYDFYGPRVLYGRAGPMTVYYGREGPTTRPIYAEPSPQSYMESLRNERQNRIVTTPLNVSRAPPQPQRNDWRQGPVQPYFPVEEDLGLFETEVISNTEVEAANQEPLRTQALTPSHTVAEEQQDNCPFCQDTITDNVFLIPCGHACCRTCLRDFATHLGMNYSPMQRLERYKCPICRGLIVDRGNLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RW28</accession>
    <name>A0A3D8RW28_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Alpha-1,2-mannosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_06038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RW28"/>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW78186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="58613" checksum="7BCDEBD04D82F61C" modified="2019-01-16" version="1">MGFATLMSERWLFGLGAVFILSTIITLILNKQQREAALGRLGLRRRRASGASTPPRSVSPIKDAKQSGPAKPDYTAQFPPSRRSALPQLAKRATDASREVFAVKEPASDFLLNDSLPFAQSFALKNDTLKYTPTGFSTVEVKAMGDFPEYDILSGVPLPKEYKEFNPATALPRPYRPFRWAYHQTMSFNKMESDWWLEIDKDYVATIEKRKGIYKKYGKMILQYLPGSELACKELMEMCLQFYCARFPKYFAISADKKTFRNGLLKEDTDLTSLHPLVVLLNNVPEDFAIVLRNEENGMYYFRAGVICSSLGWNVGTKIGMELDEIHRPIPDYKEKMSFSMDRYFSKMPTNTPIQRGSWGLEVGTPLFMPPGDPHEKLRGFQKEDLKIEDCYLRVDWQTLRRLPLSAGIVFNFTALFTPVQEFRDEPYVPSIVKKILKEGKKSLMEYKSTWHVEHVVIPKLEAYEQEQMAKGWMGQEKEGEMEWKVATLEEYPYFPGWEDKWHRQQGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWB0</accession>
    <name>A0A3D8RWB0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_06072</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWB0"/>
    <dbReference type="OrthoDB" id="4738875at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="3"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW78220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="224" mass="25069" checksum="5EF50FA7A42F4046" modified="2019-01-16" version="1">MVLILAPAEEADVFELAAIYYDSFRYDPYDRALFSDNHKEDAVNYIAEDDLYAIRNDPQTRVIKVTESGTNEIIGYARWEVPFKFENEEAREKAKRLNALPPYPASANGALGTHFQTQLSDRKKKYMDTEKDYTLVIIVISPAHQGKGAGSILLKYGIEKADRDGARIYLTAAAAGYEIYEKKGWKSLDDTIVVDAEQWGLPNGGISKTVCMMRDAVEASGHDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWZ9</accession>
    <name>A0A3D8RWZ9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_06216</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWZ9"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW78364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="239" mass="26212" checksum="DFF5960B2D868FAA" modified="2019-01-16" version="1">MTSMLWQPSGSAPSASRIRRGEEVDDASYIGLANGALYFSEPFRLPHIVPKESRSWQIVRSGTVNRRNDMSGVSMDQGCTHPPLSPSLTTDSVAGARGRGWDSVHTCKTGRHIQASPEEQLTEGKKKGRKAHVVKAGFAAGSWSRRRFLPVEPLAPASCPVQLQLTKLPSSRRRNLNDSCGESHHPTSRQLPPGKQKNPIWMVQLTRLRHAEEDPSARDVCKTRGLGNASTTGFLRASI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RX62</accession>
    <name>A0A3D8RX62_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Protein PBN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_06253</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endoplasmic reticulum membrane</location>
            <topology evidence="11">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type III membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PIGX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RX62"/>
    <dbReference type="OrthoDB" id="5546453at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042322">
        <property type="entry name" value="Pbn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013233">
        <property type="entry name" value="PIG-X/PBN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28533">
        <property type="entry name" value="PROTEIN PBN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28533:SF1">
        <property type="entry name" value="PROTEIN PBN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08320">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00780">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="456"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW78401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="494" mass="55225" checksum="610517F73D583DEC" modified="2019-01-16" version="1">MRQRITFIQEPQDSTDPKSLKVSSNSIKTTNLKAAREDKITFGFSELPQELYRVLKASHELHIRWASPKQYDTIAPLVSRVSPGLHVFYTPQRKGESSPLLCPALKKVFGDFDCESPEQSFTNLPNERFSLSAATQYYQPLENINNLLEYIRHKLCSSSDTECISRVSSLRDANSVDIGYDTISHALTLTAFWSPRTWDLDLSNSNSKDRLEVGILSVESPKEPEELSLGGFLTVVGEDAKPKATLFSFPARHHPFSSTFSAAFLSPTGLHPNLELRIDSTTPPTEERSCSLHAHLTLPRAIFPDKYQFSDPLFLASKNLTALHHVTTPVDLEAPAYAMSIWGSNLLLELAPPKSPSSSVWTAQIPLHLRYLQPTNGTAGLSKLEVPYPVLFWACVADEGSKFPINPFDRVNVGYDGLFGPKTMFYHLSPDPAVPRLTNTIEVPVLDLDKSGYIEIGTAVVVLAGFTWVMWCLFGVWKREGYGRKHEVVEKKKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RXC1</accession>
    <name>A0A3D8RXC1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ATP synthase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BP5796_06336</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RXC1"/>
    <dbReference type="OrthoDB" id="9805536at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18113">
        <property type="entry name" value="ATP-synt_F1_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18116">
        <property type="entry name" value="ATP-synt_F1_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1-ATPase_alpha_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.150.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000001">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004039">
        <property type="entry name" value="ATP synthase subunit alpha, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="entry name" value="ATP synthase alpha/beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a_nt-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009884">
        <property type="entry name" value="PRK13343.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082:SF2">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039088">
        <property type="entry name" value="F_ATPase_subunit_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 12" id="KW-0139">CF(1)</keyword>
    <keyword evidence="5 11" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="15">
        <location>
            <begin position="71"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="13">
        <location>
            <begin position="194"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase alpha subunit C-terminal" evidence="14">
        <location>
            <begin position="424"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDW78484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="554" mass="59775" checksum="BC7BB29800AF7439" modified="2019-01-16" version="1">MFRNALRQSSRTVGAISASGRIAAGRTAAPAAFNAASKQIRTFAEAKASPTEVSSILEQRIRGVQEEAGLAETGRVLSVGDGIARVHGMNNVQAEELVEFASGVKGMCMNLEAGQVGVVLFGSDRLVKEGETVKRTGEIVDIPVGMEMLGRVVDALGNPIDGKGPIKTTEKRRAQLKAPGILPRQSVNQPVQTGLKSVDAMVPIGRGQRELIIGDRQTGKTAVALDAMLNQKRWNDGTDETKKLYCVYVAVGQKRSTVAQLVKTLEENDAMKYSIVVAATASEAAPLQYIAPFAGTSMGEWFRDNGKHAVIIFDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMSAKHGGGSLTALPIIETQGGDVSAYIPTNVISITDGQIFLEAELFYKGVRPAINVGLSVSRVGSAAQLKAMKQVAGSLKLFLAQYREVAAFAQFGSDLDAATKQTLNRGERLTELLKQKQYSPMAVNEMVPLIYAGVNGHLDSVPVNKILTWEADFISHLKTNESDLLATIDKEGALSKDLEARLKEVITTFTKAFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2D4</accession>
    <name>A0A3D8S2D4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">DNA damage-binding protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_05161</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2D4"/>
    <dbReference type="OrthoDB" id="433457at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000629">
        <property type="entry name" value="UV-damaged DNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="4">
        <location>
            <begin position="12"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="5">
        <location>
            <begin position="431"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="3">
        <location>
            <begin position="789"/>
            <end position="1118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW80463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1149" mass="126385" checksum="7AA801C7EBBA0C02" modified="2019-01-16" version="1">MAYLAPIHRPSSVRHALKLNLISPEDECLVLAKANRLEIWEATAEGFVMAHSKTIYGRASMLQRLRPAGSATDHLFVGTTRFQYFTLAWNPTTRQLDTVQSFVDVAEKHLHDSQSRDRCIIDPTGQYLVMELFEGILNLVKILKPKKGKEDYLDSPEQVRITELHVRATTFLYTETNRPKVAMLFHEGKDRIVKLATYRLVDDKGQYTNFDPSRDRENVLPDLDAGASHLIPVPKGEEDGKRYIVRNAASAKAQLGGVIVVGETKMLYLDDESKAIVEYALTEASIFIAWEPYDDLHYLLADEYGVLWDLELLVDGAVVTGMEVRKIGQTSRASELVHMGNGLVFVASHEGDSQAVKVDLGGSKLEVLQTMANIAPILDFTIMDMGSREGESHSNEYSSGQARIVTGSGSYQQGSLRSVRSGVGLEDIGILADMENIKSLFTLRATAESTSNDTLVVSFLTETRIFRFDPDGEVEEVESFRGLSLDCETLFVSNLNSGLILQITATAARLYGVGPTCVAAEWQAPTGQTITAASSNENYILLSSNGKTLVALDIKKGLREAAVQTLVDGDQVACIHVPPRLDDVGVVGFWKSGSVSLLNLQNLDVIHSEDLRRADTASIPRDIALTQILPVALAGPTLFVAMEDGIVHTFNVDKNSYSLSGRKSIVLGTQQAKLQILPRNDGLFNVFATCEHPSLIYGTEGRIVYSAVTAENASSVCAFDTEAFPNSIVVATSENLKISQIDTERRTHVRTLPMGETIRRITYSANERAFGVGSIKREVIDNEEVVKSSFRLVDEVVFGELGKPFIFEGINPAHGVELVECVTRAELPVAGGEPAERFLVGTSFDLDQEGGVGDDNIRGRILIFGIDSDRSPYLVTSHKVRGHCRCLALLDGKIVAALTKSIIMYSYEETAATSATLTKLASYRTATMPIDLDVTGNIIAVADLMKSVSLVEYVPGVEGLPDKLNEIARHDQQSWSTAVVQIEEGSYLQTDHDGNLTVLQRNPDGVTLQDRKRLDVTSEMCLNEQVNKIRRVNVETSPNAMVIPKAFLATTEGSIHLFALIAPQSQDLLMRLQTRMASLLSSPGDIDFLLYRGFKNETREAAEPFRFVDGELIERFLDVDESLQATVVEGLGVGVEDVRNFVEELKRLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2L8</accession>
    <name>A0A3D8S2L8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class I glutamine amidotransferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_05204</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2L8"/>
    <dbReference type="OrthoDB" id="92161at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01741">
        <property type="entry name" value="GATase1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044992">
        <property type="entry name" value="ChyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42695:SF5">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE YLR126C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="1">
        <location>
            <begin position="69"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW80506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="253" mass="27850" checksum="BEACDF2E1EEF0CA1" modified="2019-01-16" version="1">MPGLPLRIAILECDTPLDGTRSRYGGYGGVFTALLRAGADALSYPGLSASSGLELSTWDVVNQADSYPDLASIDAILISGSRHNSFDNDPWILKLVDFVQAILAQRRVRVIGVCFGHQIVGRALGAKVDRSDKGWEASVTAIDLTKRGQEIFETPSLALHQMHRDIVYNYPEGIEALAYTEKCAVQGMYAARRLITVQGHPEFTEEIVRELLTARHASGIFEDATFEDAMGRVDKYQDGVVVSKAFLRFLLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2P6</accession>
    <name>A0A3D8S2P6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Amidase-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_05243</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2P6"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF9">
        <property type="entry name" value="ACETAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="4">
        <location>
            <begin position="73"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Amidase" evidence="4">
        <location>
            <begin position="245"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="128"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="3">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW80545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="567" mass="62125" checksum="8262415F2EB23A67" modified="2019-01-16" version="1">MAWAELAADKSARIKSAIPKEWLIKDLPTEEVSAMEFPKKSGIMSPEEIAITESSATDLVAKMAAGQLTSVAVTTAFCKRAALAHQLLNCCLEFFPEIALARAKELDEYYEKNKKVVGPLHGLPISLKDQFRIKGLETTMGYVAWIGKYEKEDSVLVTLLAKAGAVFYVKTSVPQSLMVCETVNNVIGRTVNPRNKNWSCGGSSGGEGAMVGFRGGIIGVGTDIGPFPVLKTVEAQRTCTDFHPGGSIRVPSAFNFLYGLRPSHGRLPYAKMANSMEGQETVHSVCGPLCHSIDDMKLFVTSVLAEGPWDYDSKVIPMPWRQAEEDTVNSKINSGGLTLGFYNCDGNVLPHPPILRGIQTVVDIMKKNGHNVVPWEPYKHPYAVDLINGIYASDGGTDIFTTLKESGEPAIPNFADLINPSLPKVDMNELWDVHLKKWSYQSEYLAQIKALEAKLGKELDAIIAPITPTAAIRHNQFKYYGYASAINLLDFTSVVVPVTFADKNLDVKNADFKPMNDIDKIVQDEYDPEAYHGAPVAVQIVGRRLTEEKVMAIAKEVGRLLGNETTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2R3</accession>
    <name>A0A3D8S2R3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_05295</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2R3"/>
    <dbReference type="OrthoDB" id="5370478at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="211"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="578"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="46"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="592"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW80597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="770" mass="86739" checksum="117BE33C0F5DACEB" modified="2019-01-16" version="1">MPEKQGVNTGTDSTCKACDANGRECLYPNPGTSSTPKRLEPTPGTKTEEGESKKRSRKGEDFGRRNSHRPREDVLDPSVLTEHVWNEIYAIFKKHFSTEMLFLHSAAFRTRFRQFIASKDAPAAAGEDQENGKLLLLAVLTLTARFHPGLVATYSPNAPEKPIIASEYYAEALINSEGLSGINLTIPSLERIQALLMLGLYEWGQSKGARAWVHVGAAIRLAQLMELPYEDAKGRLSAKYPSVQEDEKEVRRRTMWSCFVMDRMLSAGKFRMRMVDSNLMRVRLPSHDTRFFYGSKAEPGFLHDPVTNTDDAILNRYVRIVDIFGDVSKWSLEGGRRTEEYPPWDQRSRFYQFRRQLERFRADLPPTLEFSRFGLNAHIEMGSISAYTSMYLFYLVCLIMLHREFVPFVPLNCETGPVGPLDEPTFPKDKYDIPEGFWEDSAKILFRSAKEIVEVATFCHSEGYLPESAQICFCLWIAAFTGLYAVLFPWMDIEESMHRGQGAANGSKGHAESVVKIMNQMLSRTTMARTYVTKTGKWMKEYDEKKHQYKHQFPPLQGGGLDDYKGLEKELNEFGALEDDNRVSEEPLDGSRASTHDINTVSSNGESMQGVEGTALPPIKGWAPINSSRTVTDPDERSKLQTQNNFQYGYQSSGQGSHEGDALARLNSPYRRADGLPPFSRPNVPDQYHLPPIASTLSMAQSGAHSDLHRGPYGSLASDGHLEDNRWESGLDDYGWQSPGFDDIAQQYTEELLFEAAPQDKALANAGEAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S9Q4</accession>
    <name>A0A3D8S9Q4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nitrilase family protein (Nit3)-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_04494</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S9Q4"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050152">
        <property type="term" value="F:omega-amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006528">
        <property type="term" value="P:asparagine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006541">
        <property type="term" value="P:glutamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006107">
        <property type="term" value="P:oxaloacetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07572">
        <property type="entry name" value="nit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000002">
        <property type="entry name" value="Nitrilase family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045254">
        <property type="entry name" value="Nit1/2_C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001110">
        <property type="entry name" value="UPF0012_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088">
        <property type="entry name" value="NITRILASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23088:SF30">
        <property type="entry name" value="OMEGA-AMIDASE NIT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01227">
        <property type="entry name" value="UPF0012"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW83003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="292" mass="31793" checksum="D57A4B6D4FB944AF" modified="2019-01-16" version="1">MSSNTLLKKPVKLALIQLASGSDKAANLSHARDKVLEAASAGAKIVVLPECFNSPYGCQYFPNYAEAILPSPPSAEASPSFHALSSMAKEAKVYLVGGSIPELEPESKKYYNTSLTFSPSGDLLATHRKVHLFDIDIPGKITFKESEVLSPGNQITIVDLPEYGKIAVAICYDIRFPELAMIAARKGCFALMYPGAFNTTTGPLHWKLQGQARAMDNQCYVALCSPARDMGATYHAWGHSLIVDPMAEVLVEADESEKIVYAELDGGKIDETRKGIPIYTQRRFEVYPDVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAA3</accession>
    <name>A0A3D8SAA3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Dolichyl-phosphate-mannose--protein mannosyltransferase</fullName>
            <ecNumber evidence="4 14">2.4.1.109</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BP5796_04691</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-seryl-[protein] = 3-O-(alpha-D-mannosyl)-L-seryl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17377"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:13546"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137321"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + L-threonyl-[protein] = 3-O-(alpha-D-mannosyl)-L-threonyl-[protein] + a di-trans,poly-cis-dolichyl phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53396"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:13547"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
            <dbReference type="ChEBI" id="CHEBI:137323"/>
            <dbReference type="EC" id="2.4.1.109"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the glycosyltransferase 39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.109" evidence="4 14"/>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAA3"/>
    <dbReference type="OrthoDB" id="292747at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004169">
        <property type="term" value="F:dolichyl-phosphate-mannose-protein mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23284">
        <property type="entry name" value="beta-trefoil_MIR_PMT2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.80.10.50:FF:000012">
        <property type="entry name" value="Protein O-mannosyl-transferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003342">
        <property type="entry name" value="ArnT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027005">
        <property type="entry name" value="PMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032421">
        <property type="entry name" value="PMT_4TMC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050">
        <property type="entry name" value="DOLICHYL-PHOSPHATE-MANNOSE--PROTEIN MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10050:SF46">
        <property type="entry name" value="PROTEIN O-MANNOSYL-TRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02815">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02366">
        <property type="entry name" value="PMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16192">
        <property type="entry name" value="PMT_4TMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50919">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="147"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="230"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="284"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="604"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="646"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="672"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="702"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="338"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="404"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="16">
        <location>
            <begin position="468"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00045102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDW83200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="744" mass="84791" checksum="3929643101D78533" modified="2019-01-16" version="1">MASGTAPVASGADYDENAARRRNVPSNGSNGAMANNMEVDEKKTQIKKKEQTLLEFFDEWEFIIAPVLFTLLAFFTRLYKIGLSPIVTWDEAHFGKFGSHYLKREFYFDVHPPLGKMLVGLSGYLAGYNGSFEFKSGEKYPDELNYTFMRAFNAFFGAVCIPLAYFTARELNFKRPAVWFVTLMVLCENSYTTISRFILLDSMLLCFTFTTVLCWARFHRLQKDSFSPEWFAWLFLTGLSIGCVISVKWVGLFATALVGFYTIEDLWNKFGDLKMPKIDLAAHLAARVLCLIILPLLIYMLSFAVHFMVLENSGPGDAQMSSLFQANLRGTEVGKDSPLEIAYGSRATIKNMGYGGGLLHSHVQTYPEGSTQQQITCYHHKDANNEWWFYPNRSMPAFDPEVPISYVGDGDVLRLIHSQTGRNLHSHDVAAPVTKADKEVSCYGNVTVGDDKDHWTMEIVKDVASNDRSKVRTLTTAFRLKHTSLGCYLRAGNVNLPQWGFKQIEVTCAKENNPKDVYTHWNVEAHWNEKLPAADAGAYKSPFIQDFIHLNVAMMTSNNALVPDPDKQDDLASHFWQWPILNVGLRMCSWDDATVKYFLLGNPLVYWGSTASLAGVGLLVLWYLVRWQRGYDELKQVDIDQIHYAGIYPVVGWFLHYIPFVAMARVTYVHHYYPALYFAILSMGFVVDWVMRAQKKTVQLAIYSVLYATTVGLYVFFMPISWGMVGSNQQYSYMRWFESWRVTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAD6</accession>
    <name>A0A3D8SAD6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative potassium transporter 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_04757</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAD6"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015079">
        <property type="term" value="F:potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003855">
        <property type="entry name" value="K+_transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053952">
        <property type="entry name" value="K_trans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053951">
        <property type="entry name" value="K_trans_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00794">
        <property type="entry name" value="kup"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540:SF83">
        <property type="entry name" value="K+ POTASSIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30540">
        <property type="entry name" value="OSMOTIC STRESS POTASSIUM TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02705">
        <property type="entry name" value="K_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22776">
        <property type="entry name" value="K_trans_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="234"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="312"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="384"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="462"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="492"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="520"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="K+ potassium transporter integral membrane" evidence="10">
        <location>
            <begin position="75"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="K+ potassium transporter C-terminal" evidence="11">
        <location>
            <begin position="584"/>
            <end position="767"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF22776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW83266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="767" mass="85069" checksum="BDDA1CAA06238446" modified="2019-01-16" version="1">MADIDGGLAQRIQFSEEINPVTPGNEDTYTSALRESKVSQKTTYADLEEQALQIADADLNRKNKQIYTGWTLMWLAYQSTGVIYGDIGTSPLYVYSSTFTSQPSYDDLVGALSIIIWTLTLMVTIKYVFIVLSADFDGEGGCFALVSLLARYANIVRRDPNVAGTVKLERYLTGEISKPNKGLRNFIEKSTIARFGLKVLGVLGVSMVMSDGVLTPAQSTLGAIQGIQVASPDITKATIVGVTCAILILLFAIQPFGLSRIASSFAPIVMVWLLFNAVCGIYNLAMHDHSVLKAFSPWFAGQYLMRNKEEGWRSLGGLLLAFTGVEALFADLGAFSKRAIQISWLCFTYPCLLLAYIGQAAYISGDTTDAYTNPFFNTVIPGTFYFSLVLAILAAIVASQAMITAAFQLLSQIMTMSYFPHIKTVHTSKKFHGQVYMPFANWLLMIGCVVVTAIYSDTTRLGNAYGVCVIIVTFITTCMVSLVAILVWRFNILIVSFFFLVFAALDGVYLSSALTKIPTGAWFTLVLAAILSSVFVLWRFGKEQQWASEAEDRFQPSHLLSPTTDGNLKLTAAYGGWQVSKIHGIGIFFDKVGDMVPVVFAQFVRKFSARPEMIIFFHMRPLNVPSIPEQERYVVQRTSIPNCYRMTIRHGYGDQIVTPDLGRLIVEQLILYITRDHSTPVSSSSPISSVEHSPEVQAELDAIAMAMERQLVYVMGKEQMKIRPGTNILRRVLLSAFLWIRENSRTKMADMNIPIENLVEIGFVKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAG6</accession>
    <name>A0A3D8SAG6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein CASP</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BP5796_04848</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CASP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAG6"/>
    <dbReference type="OrthoDB" id="10257567at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012955">
        <property type="entry name" value="CASP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057476">
        <property type="entry name" value="Cux_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043">
        <property type="entry name" value="CCAAT DISPLACEMENT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14043:SF2">
        <property type="entry name" value="HOMEOBOX PROTEIN CUT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08172">
        <property type="entry name" value="CASP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25398">
        <property type="entry name" value="CUX1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="699"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="domain" description="Cux N-terminal" evidence="14">
        <location>
            <begin position="33"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="CASP C-terminal" evidence="13">
        <location>
            <begin position="451"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="390"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="483"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="621"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="743"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="158"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="264"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="338"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="442"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="566"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="496"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="621"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF25398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDW83357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="765" mass="84499" checksum="4AEA4C26260F6ECB" modified="2019-01-16" version="1">MADIPEVVMQAARSAEEDATAAEEPGTTAQDGDNKFQKAISAWRTIDLTSMVSNLDNTASEIVAYQRDSTVQRKDLAQKTKDFRKLDDTGKLGEIKALLKAYQTFIDLLTNHSKSTNSAFLQVYSSLSEAPDPYPLLEASVDSLLLSEDTLPKVTQENEHLQKSVSKLTTQLEETESRLEAESVARRALEEGLETKVKEVETSWAAVLEEKKDNWEAKEKLLEEKVENQDRLLNEIKASYEVSQRLGQSENEESGRGHVTSAELEMVNSDLERTSVRLAEVEARNEQLRIELAQSASQVPSQPTLSLEDDPGYMRMRSENSSLLRKLDASRVERDARNRDLDSKLRTFEREIGMLKEERDVLKAKVQKWSDYEDVKQELEVLKSIEFSTGDDDEADASAAANLSQEGAENGTPKGKGDTLEQLLLARNKKLSDELTILRVSHQDLQSRLQSVQDELARTNEELEKSQHLNSTLENDLATMQPHTANAFPSGASVAGTYTSRYPQSTQPAPSIYNPRRGGRISPTSSIISGFDPRGAGLGSTPLEVLRSGEPVGGGSGILPMITAQRDRFKSRNAQLETELSETHRTVSSLRQEIASLQKDNLNLYEKTRYVSTYNRAGQVSSSSSYSTNPNPSTIQMSPSQSSGVALDRYRSAYESNISPFAAFRGRESARAYKRMSLPERIVFSITRMILATRTSRNLFAGYCLALHVIVFLTLYWLGSSDMEQHSSHLGSAAAVAAAGAANAGSGSTHGNWQEEGFNGKAKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SG84</accession>
    <name>A0A3D8SG84_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_03665</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SG84"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06922">
        <property type="entry name" value="ChtBD1_GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF402">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017688896" description="chitinase" evidence="10">
        <location>
            <begin position="22"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="11">
        <location>
            <begin position="95"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW85340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1040" mass="112640" checksum="EF73A5758B1F460F" modified="2019-01-16" version="1">MSLSFQLLFFAYLSVVLPVSAQYDCDANTPCAIGCCSTYGVCGFGPTFCGAGNCTSTCDAIAECGQYATDDTRTCPLNVCCSYYGSCSGGSSSSVRTIGYYESWSTERACDVWQPETINPNLWTHLNYGFALIDSSMKISAMNSYDHTLWPTFTNLKSSNAALKCFIAVGGWAAGGAVFSEMVSTAANRATFIASAISFMNTWAFDGIDIDWEYPAAGDREGVAADTANYVTFLKELRAAGGSSIGITVTLPASYWYLQGFDVKAMEQYVDWFNVMTYDIHGTWDGDNPNTAAVVNPHTNLTEITNGLDLLWRNDIDSAKVVLGLGFYGRSFTLKDPTCNKPGCGFSGGGIAGNCSAASGILSNAEIQRIITQYDLTPTLDTTAAVKYMSWNSDQWVSYDDTDTYKLKKDYANNLCLGGTMAWAVDFDDPATSLSALNSAAGSSTLSRFLNLDDDIAINPAFASEKLSAFQSVDAATRTIFWTDCQISPVCPTGYSALTTGHGKVFDYDLQTITADGCHGGPQGSERALCIQSNMQASGCRWVGRPKQCKGTCPSGYFTLTQNSHPERDSTGCPSGKYSSYCCSSMSATSTDTCPSTWLDSQLGGGLAIRSSETITDVSDDSLSIRANTGTSNCNAWAAGAAAPGVILVNVAGYWYNNNYRPYATMSKATTTKSSSLKQCPTHIELATQTVYEIQDKTCNGDSFPQACAHYSSVISRAAGYANPLACLPTDVVATSRKLPAAWDVQHKSGWFSGYTAKSVARSCERDEYPPYLFDKGTSGKGAGWIRFLPFSDNNGAGKLWRGVCAKKYYKSSKAVNGGGVNIVYQNGVQCIQTTTYTTPYSTYPAMSMHFANMDDAVDDDLPNNGCWPEPTVPDDYAFVLFWQDEWYADNHLKLQTITDPSTAQYGKDPGTYTKGIKKISKRKLRWTDDIDPNMIFVDQRNTTRRATKEELEEHFGVVMCETEYCDEELRVRGLPSRRPNELVVTESSVPPTATAHARAASAVSTRPTQAGSLVSLDAGAPVITASPVFERWISQDENA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHR3</accession>
    <name>A0A3D8SHR3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_04214</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHR3"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058650">
        <property type="entry name" value="Msy1/2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31323:SF14">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN MSY2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25886">
        <property type="entry name" value="Msy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="436"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="390"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="14"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="735"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="838"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="740"/>
            <end position="782"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW85889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="894" mass="98484" checksum="4F5A3FD501DA3760" modified="2019-01-16" version="1">MYETEIPLTNVRTANSSTGARKPGEGALNDFDTQPTMKDDEKKGFFGTAGKRKMKKLDSKSKRIGTDGEEQSVNALGRFYKKIVNFSVVTRYFVYVLPIALVLAAPIVIFAVLYPKATIGGMRAFLFFSWLEIIWLSIWISKLVSKAIPYVFMALCGVVSSGTRKYASVLRALELPLSFVGWTVTNLVTFTALTTDQLNAFPPQNGGVSIWKSRMTNVLLSFLISSLLYLGEKTIIQLISVNYHRRSFDGRIKESKRAIHLLGLLYDASRTLFPMYCYEFREEDYLINDSIEAMLAKSTGHKRSGSATPLRFIGDVGRFGDKVTSVFGNIASEITGKEVFNPSSAHSIVIEALEKTKSSEALAKRLWMSFVVEGSESLSLDDIREVLGPARKDEADEAFEHLDNDGNGDISLDEMIMKVVEIGRDRKMIAHSMRDVGQAISVLDQVLITILFVIVVFVFVAFQDTGFVTTLATAGTTLLSLSFVFAVTTQEFLGSCIFLFIKHPYDVGDRVDIVGPEKEYLVVEQISLLYTIFKRIDCMKMVQVPNIVLNNLWIENITRSKAMKEQLDMYISFDTSLEDIDILRSEMEAFVRAPENSRDFHPDIILEAVGIGNMDKLQLKIEIKHKSNWHNETVRAARRSKFMCALVLALRKIPINCPGGGYDPAGGPNNPTYSVSVDDSYAIAAREKSKEAKAAKKFVPNKPTDPTPIAKSSGIDYLGGTTEAAAAMALNQRSPAADVAHGDNFKDDDTLGDDAERVRSNDVEQVRTLLKRESTRGRRKAGESVPSRAFDGDGGPAFRVTAASPVRDPYGRVDEEAELGFTPQDGYRTQYAPAGYGQATAGYSMFPPAQSEPPHPLQSMPTGNQPATGRLRKLSLSVKPSNNSGSGSGSGSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHU4</accession>
    <name>A0A3D8SHU4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHU4"/>
    <dbReference type="OrthoDB" id="10350977at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="271"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW85734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="369" mass="40719" checksum="F8F4F109A7B9CD30" modified="2019-01-16" version="1">MAPSDIDDEFEIVETSISSIANGVAPLPPTTQPCYPTEFNSCFRNPPATFDPRNYITPAHMSALRGGEELVHVSQCKTCTEHDSCVVVNHASGKIEHLRDHIQYNPEWARHGPVRIARYLERVVPGEVRSSRRRECEREHTHAQVRARVRRTIADELLEKTRATASRAVRGGVRSVISGASTIPRLVRQHALNTKYVRATTTNTTAIASENGAQTTRGRKAETGPDNHGENTGSEQTARSAYNDQDQFGRSDSRSEAFRHLLHHYPGLARVNDPIEFSDPVSDDEEDDEDEDESEGGQDYCNMTAGQILKRPASLDSMYRGFSVVSCAEARLAGEEHSAMGSAIKGGEKDQGEGSSWMGEGDTTRELLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHY1</accession>
    <name>A0A3D8SHY1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inclusion body clearance protein IML2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Inclusion body clearance protein iml2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_03703</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Inclusion body (IB) resident protein that interacts strongly with lipid droplet (LD) proteins. Involved in LD-mediated IB clearing after protein folding stress, probably by enabling access to the IBs of an LD-stored soluble sterol derivative that acts as a chaperone in inclusion clearing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with lipid droplet proteins.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHY1"/>
    <dbReference type="OrthoDB" id="2154985at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00043897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW85378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="625" mass="70095" checksum="B14F0A5E1A89405C" modified="2019-01-16" version="1">MFALRKTQSVASVPTHAAETEALADTLFAIESVFNNDITLAEEVLGKGHSSFHELGKALMVLLRSSLGFDGEASSNAASFLADAEAKASIQRSRVEPPRNASDSIFPAGSEYSVCQAEAQLAAAIVAVLSQRMTEYLRGLYKIRQAYMLFRGIADHESRRVRHEKLKELDIARTSAAMILDDKTLAEDESAKTLFDISTPNLMTVADTYTYTGTNLCFGALLVALSMVPSAFQQVLRVVGFKGNKDRGLALLWETSKFSNVHGALAALALLSFYNVVRSAGDILDGENYPKERCEALVDTMTKRYPQSVFWTLEEARMTACRRELEDAIQILSRPVDHPVKQLISLTLVEKSMYQMLHHDYQACSEGFIRCIALSKYSQALYYYNAASANVESYRMAQTSDPARAEEYKQQAAEYFHTALHGADMTTLLSTTLPFDALVIRKINKWQARADQLGVDLVDAVGVSPMEEMIYYYGGHKWMQRPELEQSLAMISWSEKSSLWATAEVDDRCILSLLKAVVYRWLGDLPVARSLLTGILKEDPKFFKGKLNDNWILPSAHYEMAIISWAERDEPGNNQAAKVEECAQWLDKVSKWEKYELDARISLKVKAAQDVVATYRKKTKTREKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SI39</accession>
    <name>A0A3D8SI39_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenine deaminase</fullName>
            <shortName evidence="7">ADE</shortName>
            <ecNumber evidence="7">3.5.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Adenine aminohydrolase</fullName>
            <shortName evidence="7">AAH</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">AAH1</name>
        <name evidence="9" type="ORF">BP5796_04159</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>adenine + H2O + H(+) = hypoxanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:23688"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.2" evidence="7"/>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SI39"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000034">
        <property type="term" value="F:adenine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006146">
        <property type="term" value="P:adenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043103">
        <property type="term" value="P:hypoxanthine salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009168">
        <property type="term" value="P:purine ribonucleoside monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01320">
        <property type="entry name" value="ADA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000039">
        <property type="entry name" value="Adenine deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01962">
        <property type="entry name" value="Adenine_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028892">
        <property type="entry name" value="ADE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01430">
        <property type="entry name" value="aden_deam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114">
        <property type="entry name" value="ADENINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43114:SF6">
        <property type="entry name" value="ADENINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 7" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="8">
        <location>
            <begin position="12"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="210"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="7">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW85834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="351" mass="38965" checksum="C4C0B1B31B3B6B5A" modified="2019-01-16" version="1">MPNFTPFLAALPKCEHHLHIEGSLSPATLFRLAKSNNIALPAEDPAFQSIEALQARYERFTSLDDFLGYYFIGMRTLLTVSDFETLGYEYFQKAHADGVHHAEIFFDPQAHTERGVAYKTVVEGLTAAQRRAEADFGLTSKLILCFLRHMTADEAGKTYQEASALGHFSDGTVAGIGLDSSEVGNPPEIFREVYMSAKDAGLRRTAHAGEEGDSTYISRALDLCHVERIDHGIHLVDDMELLKRVAANKTLITMCPLSNVRLRCVTKVAELPIRTFLDNGVRFSINSDDPAYFGGYILDNYLAVQDAFTLNVAEWKSIAVAAIEGSWCGDDRKTVLLKKVDECVEQFADLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SI54</accession>
    <name>A0A3D8SI54_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_04325</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW86000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SI54"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF70">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="221"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="385"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="447"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="61"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW86000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="512" mass="57203" checksum="79F024D48979282C" modified="2019-01-16" version="1">MSFNIEKAPSIRRETTVDREKGQLIVDRHADLGLQHLAKHGRVEYTAEEENAVRWRIDLCLMPILAITFGLQYLDKVTISYAAVYGMRTDLHLVGTQYSWTNSIFYFGYMVGEIPSNYLMQKLPIGKFASVNLLIWGVLVMLCAVCKNFASLATVRFLMGIFESCIGPCWVTITAMFYKGQEQGTRCTAWYSMVGVAAIVGGLLSYGIGHVKSVSVQQWQLVFLICGGFTVAWSMVVFLFLPDSPLNAKFLNERQRSVAIERLRVNRTGIKSSQFKWHQVREALRDPQVWMITLWAGISNLLNIGGSFLPLIIEEMGFSGLTTTLLTLPVGGTECVAMFVAGGLSWYFTNGRTIIMFFVSLPTLVGTILLEVLPQSATWGRCVGVWFLLCVPASYAILLSLISSNIAGFSKKITTTFLVFVSFCVGNIVSPQLFITSEAPHYGTGCRAMLVAIALVQALSMGLGSYYWFENKRRDRILAAAPSEVVDAALTENEEFLDKTDMEDSLKFRYRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SI80</accession>
    <name>A0A3D8SI80_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_04355</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW86030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SI80"/>
    <dbReference type="OrthoDB" id="3366823at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11040">
        <property type="entry name" value="CYP7_CYP8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="459"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW86030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="525" mass="60216" checksum="3B313961DD197F71" modified="2019-01-16" version="1">MVVATFVLWHKRFGDAQCLDDTIPFVSNTYQYMTNQKRFLERATDALKNNNIIKFYLGPMTVYMVAGTRNVQAMFRQSDNLSSEIMMVHLVLPRVYGLTKAEVARWERDKTGRLETPAPGTESHPKDQRYFFTLEHIYSQYLKPKRHANLLMETYFRSFSQKLDMLPIGTWVDVNMFDLCKRDMTQSAMTALIGPSIFELNPDFIDTFWEFDSIIVFLFTGLPSWLNPRPRRVQQRYFSMVRKYLDYAWANFDRNGPTATADWEPYFGARVARELNMWFRDTGLCEQSAAGFLGTLLFAENGNSVPIATWGMMEIIRDPSLFEAVREEVIQASTADPVTGARVIDAQKLISSPLLQSVYTEILRLHMSFNPTRQVTKPFKMDGYTLKKGAMVQAPMHVAHYDEAVWSVDGHSASQFWAERHVKYIETKDQSGKSIRKPEFAMAGRPSSYFPYGGGTSLCAGRNFAKGEIIMTLGLLVSKFDIEFVAWTQLDGSPSDRAAQNDGRWAGAAAMPPDREMKLRWKRLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SM08</accession>
    <name>A0A3D8SM08_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endo-1,5-alpha-L-arabinanase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_03047</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SM08"/>
    <dbReference type="OrthoDB" id="19657at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08983">
        <property type="entry name" value="GH43_Bt3655-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18828">
        <property type="entry name" value="GH43_BT3675-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046780">
        <property type="entry name" value="aBig_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050727">
        <property type="entry name" value="GH43_arabinanases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43301:SF3">
        <property type="entry name" value="ARABINAN ENDO-1,5-ALPHA-L-ARABINOSIDASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20578">
        <property type="entry name" value="aBig_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Atrophied bacterial Ig" evidence="8">
        <location>
            <begin position="33"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="744"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="916"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="7">
        <location>
            <position position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20578"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW87353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1043" mass="112712" checksum="379A627EE5C6D68D" modified="2019-01-16" version="1">MHLYWIVAPTLALAASNKHQNLTTNITAALGAVTVTNLNDVRSNLFLPWQSEGLNITWQSSNASIISCDGIVQRPSFDDQVTLTASIDYEGVLQQREFVALVRKAVDMAPFEGYAFAYFKGDSIASENIFLAASVGNNALQWQDLNGDQPILTSTLGTKGLRDPFIIRSPEGDTFYVIATDLSIGSGTPWADSVRNGSRYLEVWESHDLITWSTQRQVLVSPPTAGNTWAPEAYFDDSIGSYVVFWASSLYDEGDLNHTGSTYNRMLYSTTRDFVTFSDPVIWQDAGMSRIDSTVIKVDGIYYRFSKDEGYNGTGCSDIIEERSTDLRATLSSWTQVDACIGKKAGTGPVEGPTSFKSNPGDVNGDKYYLFLDEYTGRGYIPLETADISRPNWVVSNSSSLPKSPRHGTVISITASELTSLTTSNLSSIKAGQASTDAEILRYDFTLSKSGQLLDLSGNGRDATINGNVTVEGGIMRFDGVTDFVQLPDNLLAGVANLTVEIEVLIDDNQTTPYFIFGIGNTLSGSGNGYVYLSGDTTYHAGIASGNWQTEQTATSGSELPRGSWLNLTYTMGGSTSILYLNGAEVARNSNLSIKPSDIGNGSTTSNYIGHSTYNTDNLLKGQVKSFALYGRALSASEILSNSGNFTGIADVSLTNSSVLKFPPVVDSDIQGVIFPVFPGTDTTSLSPIFSTAAGVTTSPESGTAVDLTSNVTYTLSQGNTAIAEWTMKAVQAKSPVLPGLYADPNIAVFNQTYYIYPTTDGVPNWGGNVLYVWKSLDLVNWSRSEQPLLTLDGVNGNVPWADGNAWAPTIAERDGKYYLYFSGNNPTYNIKTIGAAVASSPEGPFTAQPTAMILNNETVTAGQAIDPDAFVDPVSGKYYLIWGNGNPLAAEFNDDMVSINWDTAIEMQGLVDFREGMFLVYRQGLYHLTYSIDDTGSPNYRVGYATSEAPTGPWTYQGVILQKDVSQGILATGHNSIISVPGTDDWYIAYHRFAIPNGSGYQRETTIDKVTFDPTTGLIQVIKPTLTSVDPEPVPAANATKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SM98</accession>
    <name>A0A3D8SM98_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_03086</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SM98"/>
    <dbReference type="OrthoDB" id="93019at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051178">
        <property type="entry name" value="TfdA_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779:SF2">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT XANTHINE DIOXYGENASE XAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779">
        <property type="entry name" value="DIOXYGENASE RV0097-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="14"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW87392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="375" mass="42048" checksum="F0578672AEFA865E" modified="2019-01-16" version="1">MAIKQLEVKPLAVPAGSKVNFGAAIYNCDVENLSDEDFETIRTALYNSHVVILKNQEKLSPKAQYELTKRFDPAAENYGHGKTLDAKRSVLHPDLKTIPHQPQVQVIGNGPFEEYEGLKDIKLVHPHHKKFHKTCVPDEEDLDFTRFFRWHMDAALYALNPPKVTSLLAVQVPQGRRQTLRYDDGTSDELDVSLGTTAFVSGQKMYDLLSEEDKEFVRNAKVEYAPHPYIWMSPSKSRSTGLGMISEGLELPLSDLPPIDESQIKILPMCFKNPLTGNLALQIHPSAVKAIHLPNGEIMTDLKEVRDLVYRLQRPGIAPALVYAHDWEQGDCALFNNQGVIHSVCGAFAPEEQRLFRQCNMASSEGVMGPDGKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SN85</accession>
    <name>A0A3D8SN85_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_03487</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SN85"/>
    <dbReference type="OrthoDB" id="370932at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1050.10">
        <property type="entry name" value="At2g23090-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039713">
        <property type="entry name" value="At2g23090-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039438">
        <property type="entry name" value="At2g23090-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007513">
        <property type="entry name" value="SERF-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026939">
        <property type="entry name" value="ZNF706/At2g23090_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33788">
        <property type="entry name" value="OS07G0114300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33788:SF1">
        <property type="entry name" value="ZINC-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04419">
        <property type="entry name" value="SERF-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12907">
        <property type="entry name" value="zf-met2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118359">
        <property type="entry name" value="Expressed protein At2g23090/F21P24.15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small EDRK-rich factor-like N-terminal" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="At2g23090-like zinc-binding" evidence="3">
        <location>
            <begin position="36"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW87793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="79" mass="8558" checksum="7A3D1542EC29541F" modified="2019-01-16" version="1">MGNGAKAASKRERAAKDGPKEAKSQLKANESAKDVQCQTCKATFLKTTRAPALTEHATNKHSKTLKECFPTFVEAPPKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXP5</accession>
    <name>A0A3D8SXP5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_02106</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW90941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SXP5"/>
    <dbReference type="OrthoDB" id="294702at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45763:SF46">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45763">
        <property type="entry name" value="HYDROLASE, ALPHA/BETA FOLD FAMILY PROTEIN, EXPRESSED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW90941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="374" mass="42537" checksum="505364F5C5BD598A" modified="2019-01-16" version="1">MAYLVSRKTANSVLHSALRRSNIALHPARSSELFAGPSVRPLSATHTPLSYTSRSPSTVETLAGVPPEFLKYPLPDHCRVLKLPDNRHLSFAEYGSKARDAHPFIFIHGIPDTRLDACLLASDQAIAEELNIRWIGIDRPGMGLSTLHPHRTVLGWVKDLECLIRHLKLEQYRILSVSGGTGYALACAKLLPREQLRSVGIAFGVGPWEAGLEGISWLNRIGLWIWEKHPWVFMRMFDRFVVPKVQEESPQKTEAMIRKQVKYMPAKDRQAIESEEAIQGLVQITREIFRQGSAKGYVEDSKLATKHWGFDLEQVKYSGIRLWYGKLDVNTPPEMGRYMATRLPNAVLKEYEGKSHFTMWDHIEEILTDMLQDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXP7</accession>
    <name>A0A3D8SXP7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RecA family profile 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_02219</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SXP7"/>
    <dbReference type="OrthoDB" id="5957327at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033065">
        <property type="term" value="C:Rad51C-XRCC3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000707">
        <property type="term" value="P:meiotic DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01393">
        <property type="entry name" value="RecA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052093">
        <property type="entry name" value="HR_Repair_Mediator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049428">
        <property type="entry name" value="RecA-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3 RAD51C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00154">
        <property type="entry name" value="RecA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="8">
        <location>
            <begin position="38"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="342"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="357"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="400"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="431"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW91054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="443" mass="47714" checksum="6E2519EE426A82D2" modified="2019-01-16" version="1">MDYQSVHGHDVSNFSSSPPHRMPTVSAAQALEDLKTSPTRCLSTGLALLDAVLQNQDGEATIPGGVSRGKVTEVYGPPGVGKTALGMQMAANVLHAGKRVIWVDTAHPLPGPRFSQILTSCQNSHPISSEDKLSESTFSELLRNLTHFSTPTLAHFIALLCHSSTNFPVSEASLIVIDSFSTLISNAFPRTVDASATPKKPGAPNPGARKFPILQYIINALSKLAATRNIAIVVLSQCVTKMQPGSAAILVPAINTTAWDQGLCCRVALFRDWGWEQEGNEGDSTISYQVRFAEVVKAEGITAPNGRGRLVAFAIDENGLQPLAIPITLPISALPQNPIDTSPILPRKRKFSTADLEVPDSEGEDDEDYGWGEQDEETVPEMPPQWQGSEDILVPAPKDLEEEEEEEEDEEEEVEDEAVERLGVAGGIVPEVDDSEDELAAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SY10</accession>
    <name>A0A3D8SY10_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02387</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SY10"/>
    <dbReference type="OrthoDB" id="3445164at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="110"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="232" mass="25843" checksum="EE09EA8FD9E56DC3" modified="2019-01-16" version="1">MATLIASMADASALKRKFVPELVEIERISRKAGGDRTVEHLSPEDASSLAAISAKWCLYRAQVQLQHEYASWLVTRSHASPRRRFTPELIETTRRYRKAENRAATGPSLHALPTELHFEIFSYLDNIDATCLGVTCKNAYGVYQATHANVPLTQRRVGPNKLESAWSYLGKQQCTHCGLYRCELHTHLASWVPADVEYCALKGKFGPAAAPGARSTCYRGIPSKPHVCGRHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYE6</accession>
    <name>A0A3D8SYE6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_02517</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYE6"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF2">
        <property type="entry name" value="AFG1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="131"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="644"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="696"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="658"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW91352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="715" mass="80366" checksum="3FE9482E3301A38D" modified="2019-01-16" version="1">MPPLLTPLTSTATGLTITNPLILYRALLSTKQIDPDPSQHRLALHLQKLYFRLKDYTPADEYGARLRAITQATASKENESKEDEERSVAVKSHPLRRNPLFAHLFFKKERSDTLALTRILTNHELAMNLDSPRGLLLHGEVGTGKSMLVDLLADSLPNSKKRRWHFNTFMLEILARLEQARLQGNQEYSLLWLAKDMIEKSPILFLDEFQLPDRAASKILSNLLTSFFQLGGVLIASSNRMPDELAKASGMDFSAPSRGGMVRKLLGLRPVGPGLPDAGAGEYASFVEVLKARCETWDMEGGKDWRRREVDQDLEGGDIEHMREEMVEGFEGLEKLRPGNLGQGHEQSILADQLDIKSTTEKLLVPRKYVLVSSSNNDAWDQVVRSALKSGTPDPTPWEPTTLLVYGRQIPVPNHFDGVTMWSFQDLCGGFFGPADYITLASRFHTLILDQVPILTLSQKNEARRLITLLDALYEARCKLVIRAEAGPDELFFPETNLAVNTDGTQQSNDEGDAVYSETISEIYQDQTSPFRPNITSYTDEPRTGYDPDQDSDFGSMPGKGNEIGRQVDFGMGSSFTGEDERFAYKRARSRLWEMCGTRWHARSDPGWWRPLPLEVRRWERSASSTVQAQKRITEIEDSDVRLGESIELDRPAGLQGKEIEEREKQTNSPVKKESIEPPQIGGWHAWGITQWAKKAGAWGQGPEGLAQRKEKGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYK7</accession>
    <name>A0A3D8SYK7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">methionine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Methionyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BP5796_02557</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tRNA(Met) + L-methionine + ATP = L-methionyl-tRNA(Met) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13481"/>
            <dbReference type="Rhea" id="RHEA-COMP:9667"/>
            <dbReference type="Rhea" id="RHEA-COMP:9698"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78530"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.10"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYK7"/>
    <dbReference type="OrthoDB" id="5844513at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.20:FF:000001">
        <property type="entry name" value="Methionine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000031">
        <property type="entry name" value="Putative Methionyl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.20">
        <property type="entry name" value="Methionyl-tRNA synthetase, Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023458">
        <property type="entry name" value="Met-tRNA_ligase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029038">
        <property type="entry name" value="MetRS_Zn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765">
        <property type="entry name" value="METHIONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45765:SF1">
        <property type="entry name" value="METHIONINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57770">
        <property type="entry name" value="Methionyl-tRNA synthetase (MetRS), Zn-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 14" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 14" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="18" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="16">
        <location>
            <begin position="16"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl-tRNA synthetase anticodon-binding" evidence="17">
        <location>
            <begin position="438"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="568"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="578"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDW91392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="640" mass="71845" checksum="9E0D2B5EE6934BCE" modified="2019-01-16" version="1">MASPKIILPEKGKNNILITSALPYVNNVPHLGNVIGSVLSADVFSRYSKLRDRPTLFICGTDEYGTATETKALETGQTPQELCDEFHKKHKEVYDWFDIAFDYFGRTTTEKQTEIAQDIFLKLYKNGYMEERTTTQPYCEKHESFLADRFVEGTCPKCQYDDARGDQCDKCGSLLDPFELINPHCKVDGATPVPRETTHIFLKLGKAQPDIEKWFNKSSVEGAWPQNGISITKSWLDKGLESRSITRDLKWGTPIPLPGYDKKVLYVWFDACIGYPSITANYTDDWELWWRDPENVKLYQFMGKDNVPFHTVIFPGSQMGTGDKWTMLNHLSTTEYLNYETGKFSKSRGVGVFGDTAKTTGVPPSVWRYYLLANRPETGDTQFEWRPFIAANNSELLNNLGNFVNRLVKFVNDKRFKLEGVIPEFSPDYTEDSFDFPEFIASVNSLLAEYVADMEAVRLRAGLKKMMEISTKGNELLAGRLDKASLEGNPQRTNTIIGLSLNLAYLLASISSPFMPATATSICEQLNAPLISIPDKWAPGTLASGHKIGKPAYLFTTIDPKKEEEWRTQYGGTQASRLAEEEAKAKKKAEKEKDKEKKRLKKEAEKAAKAGAAAQSAESVEIPLRGKVAEEQAPPPAAAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYW7</accession>
    <name>A0A3D8SYW7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02667</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYW7"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="134"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="279" mass="30305" checksum="0A4B1DDD8302DDC6" modified="2019-01-16" version="1">MWALGVVGGRFHSYHTVDILVTDSVADENRCLGYGEHGIRDAHEDSDSPWAARCPRPALATRLASHAQDLPRTSPSVPAVDRTRSGAFFRSAEADEQSGLVGQDAIDASGDPEAALDASAPRPATTTYQPTGGREPERKSDQHFGPDLMSPTLEPTLQACFPEIRTLLRVLLHRYGNPRHGVANWTHVRPPVPTLRSNPQATGTAARNRPGRLGFLLLWEPGPRRGRKTIVANVAPNTVARWMTSHYATSVSNNARELALPLSPPLLARMSLPFAASPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZ09</accession>
    <name>A0A3D8SZ09_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Altered inheritance of mitochondria protein 19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02685</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZ09"/>
    <dbReference type="OrthoDB" id="4868994at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="14981" checksum="88B8B25382BCEC6B" modified="2019-01-16" version="1">MVAEDKNVQEARKGALAIAQDWGKSPLPPTLLATLITALHARPLQKLPLAFTPVLLFSTYLNLNNFVIDSAGLTAAWSGLYLLLARRRRAGGANFSARFGNRFGARGLTRGAAMLLAGANVVGCGTTYALGRRSKEERVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZ26</accession>
    <name>A0A3D8SZ26_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZ26"/>
    <dbReference type="OrthoDB" id="3543352at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="134"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="703"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="950"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1188"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="543"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="714"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="950"/>
            <end position="964"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1255" mass="133231" checksum="5DEAA0B0A2C29CD3" modified="2019-01-16" version="1">MNNEVTNPPAAVDGNGPTQVQHDLNLVYQAMMEELGNERMDSLPLEDGNSRGREPDLPDPTLASMLPARSAALDSEASAWHSFAEENQKPGSEGLASIYNGQLHHLRRQQKDAQLPNGYKQSQLDELKAFNASLTRAGSKSGRGSSDGRGGRAGGGSTRGGHASVRTPQQIIGHHLGSQHTKSGSKSTQQGQTPRKKQINAAMARLSSYATGIRSGSQPQQAPSKNVVGPPRPMVFGLASPEVFLSHTGIVAKPMPGSTSMTSSAANGTSNTTGTAPKPTKTPSQGLAASRYALPSDKVHAATAQHAAIIHAHPPQKSMSEIPAGQTSTLLAPNSQSLITQLSTSSISSPPVATDKADSSKISTSDIDLDQLLKYPSPRAPGEFVVFKETIKISTGTMQQECGELRLVARWGYPYFSLEIEAGDSVSISEVLSRGSIFETEAKRSSFVKFVPAPTIGISASCTIQFRVPMLATQAVQMAVKDPSLLIPPVDPSFRINPEALLLVDEAPYAPVRSPHFHDMLAIDNGQPLIPEVDDPTAQSGLPQPAAPQSNAASPALQDLMHLLITDDLVSSTLDKLNAEPQGPFLDQVAFLVAADPEASKDAQLAAKFNRVLTNGLTSSAWCNGQSQSELKLKAATAAIVLNHIERGGGSVMQQIMGAYPNFSTHLAHAIFVEAKSREQAQSLQHPTISANFKAQSDPDWKLFSNDAERSHSSQKGATSGQENGETVEPRNSAALTTPPITLKENLLGSNDSAQDGEQTGEPPKLEGNTTPLKIEGRTTPKTAERRVVYSIQELTALRNKAYTVKNTLPQPVIQTARRLKSPPQSENIVQVTRTGIPVVAGIDTALRSPRSHVLQAPEIVHQNAMTKRGHGSTLSTSPAQTTPMNIPFIESGLETHTASNIRGFPSSISDHSGAALKQTSAKELNFEEERESNVNTPDIHAAIHNTLPVSNSLRPGTKNSSHSLPGKENVMLDIGSSSSASEAPSEKLGQTLKASVEAQMSSSDEVEHISKLSRSATAAHAKKVGPSATSNISDTTSLVDSVNASISRNSRPAKAISNSPESEATVSLTKTPEVNLNGGLMASRWVLSNTAAPKETRYRGFNAPSRLRAPVLPLGGTPPGEGIDHLSQSFRNISVAPLTSLPQPIPQAQPVVNPSLQSSNYQKVWVPDVSGNWIETIAFVPQQNQTIHSNPGAKQEHGSLSPFSNPASMLPVPHAGPSGTTARPVLSPIPSNNVQADLQKRLSQSLRNRSGPHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZP4</accession>
    <name>A0A3D8SZP4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter-53</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_01179</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZP4"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF33">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="262"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="395"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="426"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="462"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="67"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW91785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="558" mass="59437" checksum="4962EBABD36980BB" modified="2019-01-16" version="1">MASSTTTISNASNEPSIDEYTPLLNGKAASIGEVVIYVSETDEEAAGYHSLLPDNQPQETSRSVVGIIVILLLGIFIANADGSLVLATSGTISSEFGDLENARWLLSSYTLAMCATQSLYGKLSDIYGRKTTILASYMFFTVGCAICGLGQSLPQVVFGRLVAGVGGAGINCLVSIVIADLVPIREAATWRSYVNIAATSGRSLGGPIGGFLTETIGWRWSFLGQCPPTLLASALVIWELQVSCHQDNRNEGHLSKLRRIDFLGAILLSVSIVCGLLVLDFGAQRKPWTHPSVSWLLGASLAAGNLFIVVEGFWAKEPIFPLRLLLNRDVVTSYINLGFQTGAQMAMMMLVPMYFQISAHSSMTSAGAHLMPSVIGNAVGGLLTGYIIRRTGRYKIISIIGAVSSASSYLLMALRWHGHTSFLESLYIIPGGFGNGIALSASFISLTAGVEPCQVAIASSGLFLSSNIGMVVALSLAAAILQSTLRKQLGISLEGVEGRDQIITKALSDIEYVRSLRGWVGQIVTEAYIRSLAYTHSISLIGEMVALIAALCIKEHVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZR6</accession>
    <name>A0A3D8SZR6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_01211</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZR6"/>
    <dbReference type="OrthoDB" id="2116389at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF8">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G03000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="154"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="461"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW91817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="521" mass="56152" checksum="BBCE3A95C3B97F8B" modified="2019-01-16" version="1">MSTTDDKAIEPRKTSVSSPENSPSICRGDLEDATAIPDDFITNKWQRKANELIGLAGAEARGIERVDEIFRTGRLALKDYFSLTIVWFSVNLTSNILTIGVLGPVTFGLGSLDSMLCCFFGTILGSAATCYMATYGPMSGNRSLVGARFSMGWWPTKLCVILAVVVMLGYGLVDAVTTGLIFSAVSGGSLSTIVGIVIFGIMVWVISSFGIKYVKHYEEYAYVPQVCALFILVGVAAPYMDVHAKSALTGKTLIGARISYLFTCASGPLGWAPFIADSLVYHPPSTSRVGVFFSTFIGFVASKTFVEFIGIGLGSGLATNPTWAAGFNATGVGGLLVAAYDPLGSLGHLCAVILGLGIAANMVPGNYSAAFCAQLIATKAEKIPRIVWNTLATIIYTVIAIAGRNKLLPIFSNFLPLIGYWTIIWIVITLQEEWLFRRRRNPTKPYDWAAWDNRNLLPMGIAAFTTFLIGWAAAILCMSQAYYIGPIAALVPADMGLPVAAAWSAIVYPPLRYMELKKFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T082</accession>
    <name>A0A3D8T082_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cut9 interacting protein Scn1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_01369</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T082"/>
    <dbReference type="OrthoDB" id="413993at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053044">
        <property type="entry name" value="Metallo-hydrolase/TatD-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47345">
        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47345:SF1">
        <property type="entry name" value="CUT9-INTERACTING PROTEIN SCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW91975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="43346" checksum="32772CA2678C93F0" modified="2019-01-16" version="1">MASPTSETLNAGAFPWHLGVYDAHCHPTDTMGTVASISTMKARALTIMATRAQDQELVAQVANAHGLEAPPEGEAREKCVVPCFGWHPWFSYQIYDDVVGPKVLDLDSEAFRIHHYQAALTPKSEDMVFLKSLPPPRSLSEFLQETKKYLEKYPKALVGEIGLDKGFRLPSSWTEDLEGNRDDGLTPGGREGRRLSPYRVQMAHQKAILKAQLNLAGEMDRAVSVHGVQAHGVVFDTLQETWKGHEKEVMSAKERKQLSKVSNIDVEDDIDEPKSKQRPFPPRICLHSYSGPPDTLKQYFHRTVPAEIFFSFSSAINMSTAASAKAIDVIKAMPDDRILVESDLHIAGSDMDDRLEQMCRKICEVKGWNLEQGVTQLGENWHRFIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0F8</accession>
    <name>A0A3D8T0F8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_01305</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0F8"/>
    <dbReference type="OrthoDB" id="2595934at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF19">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="112"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="112"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW91911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="579" mass="63592" checksum="9840D9B07188028D" modified="2019-01-16" version="1">MTNDKESTDVDSHTSPDVARSRKRRRVLACDTCRRIKSRCDYESHNGSCNRCATLRIPCSLSDTSGGSSAGSVAIVQGKANELSLLRDLHAKLAEQTALLQDLKKTVERQALNEQPLPSTRSQIEASASQHDAENTDSPADQDTESAPVVMIRNVLRKGKGGFKRLQNQGIDGLLDLGLFSAHTAYELLDLFLARAGPWLQLTAWESIGIRSDMNQSVSSNLIAACVLQGMALSELRNSATHETFYDGHAVQQAMLTINFTNLRAKIKKGTSDVVDRHTLRTWNHICLSHLYFAVGTGRPSLIAESYLDQCPSILNAFEPTIQDQTVLAEIHFYSAILKLLTTALPLQADGKCKELDAWHDKWGYLLKLKTDRALASLMSYDFGYLVIAQRSLKNINAPSPTTPQSNHPVHPNTHDEVQKAFILHSITYSTAVLESLTKLEPSFAESMPNHLYLSVIYSILVLVACHSTSPDPTRTLSTIRTAMKYCKDSGIGPLAAAEYAISKLEEKIQDKEQAGNEVPLVYTEGNDALLTDMWSAGNPPLSFDMLQDSGFGFGGLAFPSLDELFGANFAMPEDTFAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0J5</accession>
    <name>A0A3D8T0J5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Small nuclear ribonucleoprotein E</fullName>
            <shortName evidence="11">snRNP-E</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Sm protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_01491</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in pre-mRNA splicing. Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Involved in cap modification.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0J5"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01718">
        <property type="entry name" value="Sm_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000031">
        <property type="entry name" value="Small nuclear ribonucleoprotein E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027078">
        <property type="entry name" value="snRNP-E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11193">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="17"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW92097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="95" mass="10512" checksum="C54BBC12424A614A" modified="2019-01-16" version="1">MTGRGGGGGRKVLLPPINFIFKLLQSHATVQIWLYEQLAIRIEGQIRGFDEFMNLVIDNAVEVKQATKTTEESRRSLGQILLKGDNVSLIQSLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0K2</accession>
    <name>A0A3D8T0K2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BSP-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_01480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0K2"/>
    <dbReference type="OrthoDB" id="891726at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007541">
        <property type="entry name" value="Uncharacterised_BSP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33321:SF12">
        <property type="entry name" value="PLANT BASIC SECRETORY PROTEIN (BSP) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04450">
        <property type="entry name" value="BSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="267"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="293"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW92086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="33769" checksum="5AD0DA7BA47DCB5B" modified="2019-01-16" version="1">MPIAPGTTPVPPPVFMPQATSVPTPSPLPHRPKEAQKPITSEPATSLKKDAFALPTLRLEVRDLNHDGSQAFLSSVVASKALAEAVQNVLRLLYASPKSPTTTVPPTRSVTLILRGMGGVAYTTGSELDSDHKEIHFSLDYINGIATERKKHEIMGVLTHEMVHCYQYNAFGTCPGGLIEGIADWVRLNSDLSPPHWKKVTSGKWDQGYQNTGYFLQYLEERFGPGLVQRANEKLRIARYHEKEFWTELCGRPVEQLWGDYGEAMKTEQNTKEEEEGILVEKEDAAPSVESAAAKKKEPSTTSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1F7</accession>
    <name>A0A3D8T1F7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1275 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_01754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1F7"/>
    <dbReference type="OrthoDB" id="5288586at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010699">
        <property type="entry name" value="DUF1275"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488:SF7">
        <property type="entry name" value="DUF1275 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37488">
        <property type="entry name" value="DUF1275 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06912">
        <property type="entry name" value="DUF1275"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW92360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="30303" checksum="A7D46ABBA75C297F" modified="2019-01-16" version="1">MSSNALIAPPAPALNGQTNATADPGLPITENQASAQQPAQRPLLSYFKTEITIAHADLPIIACCLVSGICDSSAYNAWTCFVSMQTGNTIFLALGASGQPITRPFGWLKSLISIFFFLCGCLFFSWTRLINAKGRGTLAGSFFIQGSCIIIAAALVQAGVVPGPNGVVAETGSEVHFIELIPLAFLAFQSGGQIVTSRLLGFNEVPTTVLTSVYCDLASDPNLLKADNVKRNRRACAVLAILVGGIIGGWMSRRTGLSSALWLAAAIKITISIAWGFWRPNQALRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T2Y0</accession>
    <name>A0A3D8T2Y0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Lysosomal dipeptide transporter MFSD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Major facilitator superfamily domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BP5796_01752</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79415"/>
            <dbReference type="ChEBI" id="CHEBI:192470"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)</text>
            <dbReference type="Rhea" id="RHEA:79367"/>
            <dbReference type="ChEBI" id="CHEBI:229968"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)</text>
            <dbReference type="Rhea" id="RHEA:79375"/>
            <dbReference type="ChEBI" id="CHEBI:229967"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79383"/>
            <dbReference type="ChEBI" id="CHEBI:229966"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79371"/>
            <dbReference type="ChEBI" id="CHEBI:84315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-arginyl-glycine(out) = L-arginyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79391"/>
            <dbReference type="ChEBI" id="CHEBI:229955"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79411"/>
            <dbReference type="ChEBI" id="CHEBI:229953"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79379"/>
            <dbReference type="ChEBI" id="CHEBI:229964"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>L-histidyl-glycine(out) = L-histidyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79395"/>
            <dbReference type="ChEBI" id="CHEBI:229957"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)</text>
            <dbReference type="Rhea" id="RHEA:79399"/>
            <dbReference type="ChEBI" id="CHEBI:229954"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79387"/>
            <dbReference type="ChEBI" id="CHEBI:229965"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79403"/>
            <dbReference type="ChEBI" id="CHEBI:229956"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl-glycine(out) = L-lysyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79407"/>
            <dbReference type="ChEBI" id="CHEBI:191202"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="18">Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T2Y0"/>
    <dbReference type="OrthoDB" id="424834at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052187">
        <property type="entry name" value="MFSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512:SF12">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G00260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="326"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="357"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="423"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="20">
        <location>
            <begin position="42"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00045018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00045709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00046376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RDW92358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="513" mass="55864" checksum="C197C3B13793D304" modified="2019-01-16" version="1">MTTSEPKSKHEVVIAVGEAGSDSEAGENPKKVAVPLKWKLASILMVSAIGFGSHWSSGITGAMKSTIKKELHINNTQYALLEASEDFMITLLMLVSGVVTDRIGGAGAILYGNLLFTVGSLLVAGAAQVQSYRFMIGGRVIQALGDIATQVAQYKIFSSWFPPSHGFASTLGLELGIGKIGAFAGKSSANIISQNTGNFANVFWVAAGMNLFTNVMTAGFYWFTNVANRKFSATADPATGEQLTEKNKKFELRKVLELPWVFWAVMAFSLFETSTAIVYTQNATELAEQRLGVSAVKAGWYTSVVQYGGFFIVPLLGVFIDIWGNRLTILLVCGLGVFLSMCLVNWNTQMSGTSASFAIYAVAYCFGPATIIDSIRTSLWDQSVFGSAYGIKITVNNAMNIVVRVVCGVLQDADNNSYDTVSIVYVFLAACSVLVSILLCVFACFDVDLRRLQWTRKQRVAKGYIINERNEKFHNENGDRNRLVSKICFISVIFLVLGSWCGYFWGVATGNND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T6P8</accession>
    <name>A0A3D8T6P8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_00025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T6P8"/>
    <dbReference type="OrthoDB" id="10331420at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW94262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="15003" checksum="7B523EAEE350A54D" modified="2019-01-16" version="1">MYKPSSPSVPAPHTDKQSTSPTNPKPTGSPIRPLPRTSDYPCIRIILRRSSTEEERSLGCRPSTRVKAIKNWAATNFKIARRHVGIFINDVPNRPLRPEEKGEDALESDEDLDEFEIEDGWTLYVRDLKTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7J0</accession>
    <name>A0A3D8T7J0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase epsilon subunit D</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">DNA polymerase II subunit D</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_00315</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7J0"/>
    <dbReference type="OrthoDB" id="1707486at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008623">
        <property type="term" value="C:CHRAC"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22928">
        <property type="entry name" value="HFD_POLE3_DPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051377">
        <property type="entry name" value="DNA_Pol-Epsilon_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46172:SF1">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="33"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00042096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW94552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="119" mass="12462" checksum="4262050815FF45DB" modified="2019-01-16" version="1">MPPRKSDASKATAATTAVTAVVTGDEGAGTPAKETKETKEAKEKEVRGDGVNIEDLNLPKSIVTRLAKGVLPPNTQIQGNAMLAMSKSATVFVNYLASAYVPSSAVRLEGMSRLRSTTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7K6</accession>
    <name>A0A3D8T7K6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR-containing protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_00300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7K6"/>
    <dbReference type="OrthoDB" id="1914839at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd24142">
        <property type="entry name" value="ACL4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW94537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="398" mass="44288" checksum="03B07AA969F0D8AF" modified="2019-01-16" version="1">MAKTKPNNKRTKKSEKPTLNRVAPSPSKSSATHMSPTLLLAQATATLQQGDIEGSVPYAQRALGLVDIDSTEALPALNLLGEIHVELGDIITARQYFLQAAIIDEEGTLGEDIGGGAEKFLWLAQLSEDGGEDSVRWFEKGAMSLRIQIQALLDRKKLDMEMEQFLEEKQRKLAVALCGVVEVYMTDLSWEEDAEQKCEALVTEATMVAPAFPEPWQTLANVRLSQSRVEDAQAALKRSLDLWKDLPPENDVVPDFPTKVSLARLLMEADMDVEAIEVLERLVNEDDSSVEVWYLGGWGLYIMGEKQKNGESKEADGDGESWKVSWISSRQWLTHSLRLFEAQSYEDERLGSHAKELITNLNKELGEPAEGDMDTQAGDIWEDDDGSDLDNDEEMAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T851</accession>
    <name>A0A3D8T851_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HORMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_00483</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T851"/>
    <dbReference type="OrthoDB" id="1928087at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051294">
        <property type="entry name" value="HORMA_MeioticProgression"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225">
        <property type="entry name" value="HORMA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225:SF7">
        <property type="entry name" value="MEIOSIS-SPECIFIC PROTEIN HOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="7">
        <location>
            <begin position="65"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="350"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="448"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="353"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW94720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="477" mass="53027" checksum="F3C1EFEA6DC43031" modified="2019-01-16" version="1">MPPRKRKNGKSTKGGKSTKGILVQPVRPDSQTLSDLSQRSQDQVPQSKLLTDVPNAEQQAFVNKVQSVELVLTLIKLIAATITHKRNIFRDASYAHCNVDMDALVASHDALLECEVKGDDGTKDYDMLVYCFRPDGHPRIKKLLHLIDVGAREALERGWLKSFDLIFHDSGNKVIERWGIKIKYDAGTPSIHVLSPSSSQVLTQPTVKRLEDVTKQLTEVLFEMWPDVKGMGDFPNGIRIAAVLGWNNKAPPQYSPKGCRPYNQNTDLAVFDQKHAQTFTKGMETGFHGVEIDVEHPTTTDEDSQETIQEVGNDNEVIDMKEYEQQGLLKDMALPLRQPSLLDTQDTVELPQSKLSAKSPSRQSTVVVTTPHLPDRAASKYLNSNEYRTPQVRAQGSPSSSPAGWDDTTLEGTPLVTPIANKHVRDFSEFKNEPYLAPNSASEIFQATQKRAKRLGPSAFSSLDSPIDHTRTSSHPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8U5</accession>
    <name>A0A3D8T8U5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GMP synthase [glutamine-hydrolyzing]</fullName>
            <ecNumber evidence="4">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">GMP synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BP5796_00775</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the conversion of xanthine monophosphate (XMP) to GMP in the presence of glutamine and ATP through an adenyl-XMP intermediate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>XMP + L-glutamine + ATP + H2O = GMP + L-glutamate + AMP + diphosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:11680"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:58115"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.5.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8U5"/>
    <dbReference type="OrthoDB" id="1724632at2759"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003921">
        <property type="term" value="F:GMP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000002">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000001">
        <property type="entry name" value="GMP synthase [glutamine-hydrolyzing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00344">
        <property type="entry name" value="GMP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022955">
        <property type="entry name" value="GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00884">
        <property type="entry name" value="guaA_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000848">
        <property type="entry name" value="PRK00074.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922:SF2">
        <property type="entry name" value="GMP SYNTHASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922">
        <property type="entry name" value="GMP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00096">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54810">
        <property type="entry name" value="GMP synthetase C-terminal dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="8 16" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 16" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="17">
        <location>
            <begin position="211"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="239"/>
            <end position="245"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDW95012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="542" mass="59912" checksum="83CBDAB074B3355E" modified="2019-01-16" version="1">MSATAQEIEPHQLFDTILTLDFGSQYTHLITRRLRELNVYSEMLPCTQKLADLTWKPAGVILSGGPYSVYEDGAPHVDPAYFELGVPILGICYGMQEIAYRSNATNVIAGTAREYGHADLQAKKVDGFVDRLFEGLEGNMKVWMSHGDKLAKLPEDFHVIASTQNSEYAAIAHQTKDIYCLQFHPEVTHTINGVQLLKNFAVGICKAQQNWTMAKFVDQEIARIRALVGETGQVLGAVSGGVDSTVAAKLMKEAIGDRFHAVLVNNGVMRLNECEQVQKTLTEHLGINLIVADASKLFLDGLKGITDPELKRKFIGGTFIDVFEAEAKKIEDAAANSPKAGKINFFLQGTLYPDVIESISFKGPSATIKTHHNVGGLPKRMTEGQGLKLIEPLRELFKDEVRDLGRQLGIAHDLVMRHPFPGPGIAIRVLGEVTPERVEMARKADHIFISMIREAGLYDKIGQAFAALDPSRAVGVMGDKRVYENIVLLRAVETTDFMTCNPFPFEHEFLVRVSTRIVNEVQGVCRVAYDYTSKPPGTIELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8W6</accession>
    <name>A0A3D8T8W6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Urease accessory protein UreD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_00738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8W6"/>
    <dbReference type="OrthoDB" id="5876637at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40644">
        <property type="entry name" value="UPF0653 PROTEIN C607.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40644:SF1">
        <property type="entry name" value="UPF0653 PROTEIN C607.02C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW94975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="343" mass="38154" checksum="A299E0B1BFDB517A" modified="2019-01-16" version="1">MPHKHTRKSLDDKATINLPPSEIAKPLSTSKSAGTNGIFTSSLERSSGSRDAKGRRTKKRKRDDADDTPRAFARLMMFREGKKLPSGLDDGVKKVRKSKHLPDAPAPRKKNEKGTPVKAEADAPAGQEVEGAIPTIRPGEKMSEFSARVDAALPISGLITKTTKQGKDPLGLKVGRTKTEKRMHRLYAEWREEERKIQEKKEEDAEAREEEELAEDDEGRVRWKADLDGAAGPASGGKKKKGKKGKKRYLGEVDDGEDDPWAVLKQKRNEGPRRLNDVALAPPSLKKPKEKFKIKEGARVDVGDVPKASGSLRRREELGEVRRGIVEGYRAMMKGNQRVEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T930</accession>
    <name>A0A3D8T930_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_00714</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T930"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF50">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="476"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="506"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="237"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW94951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="551" mass="60846" checksum="FF688BA1857724EF" modified="2019-01-16" version="1">MEHNNEQDAEQWPPGTIRLETIQRSNGNDIILQPRPSSDPNDPLNWPRWRKNWNFSLCCFYTLMVFALIDAATPTWAPMNVELGFSYAILNDSYAVGCGTLAFGAFLLIPFALKYGRRPIYLFSTLAQFAVSVWSAKLQTVADIMLVNAFSCGVGALAEVIVQMTIADVFFVHQRGLMNTIYIWSVNVGGSLAPVAAGYITLSQGWRWVWWWNAILFGVCFILFAFTYEESKYNHSTLSGVSPEEHDVVPATGPSSKDALDEKALPVNPSDRASNEEVSALHDSTQLSIDQSIPKKSYWQKLAVTSTSAGSFKTFARHSYQPAVILFTIPGVGYMSLVYGVMLAWSTVMVTILSSTMTLPPYNFDSAQIGLMSLPPFIGTTLGSLITGPLSDWSILYLSRRNKGVYEPEMRLWMMVPFIPFVPIGALMFGIGLNNGLSWPIIAVGYAICNFGVAPISSIALTYITDSYTDIVGDALVAVTFTRNAVGTIFVFALSPWIAAVGISNVIITITVIGTAVLAFVGVFIVWGKKMRVKNAERYRYYAGRQFDYRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T981</accession>
    <name>A0A3D8T981_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Maltose/galactoside acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_00883</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T981"/>
    <dbReference type="OrthoDB" id="25818at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03357">
        <property type="entry name" value="LbH_MAT_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000025">
        <property type="entry name" value="Hexapeptide-repeat containing-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051159">
        <property type="entry name" value="Hexapeptide_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416:SF23">
        <property type="entry name" value="ACETYLTRANSFERASE C18B11.09C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416">
        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Maltose/galactoside acetyltransferase" evidence="4">
        <location>
            <begin position="27"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW95120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="219" mass="23985" checksum="533D5D40FB598DE9" modified="2019-01-16" version="1">MGASTEKNAELIEHAKTLRNIPWCEDYEKMISGMLYRCLAPELVTARHRARRLAIKYNTDFPDDAIPESLESDRAAKLQEMFGSVGKGVYIEPPFFIDYGCNISVGDGFYANFNMTILDCGFVTIGDRTMFGPNVSIYAATHETGVQSRRDGVEYAREVIIGNDCWIGGHVTIMPGVTIGDGCTIGASSVVTRDIEAWSVAIGSPARVVKKVDPVPPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9M1</accession>
    <name>A0A3D8T9M1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BP5796_00987</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9M1"/>
    <dbReference type="OrthoDB" id="448399at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06133">
        <property type="entry name" value="ERI-1_3'hExo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12452">
        <property type="entry name" value="RRM_ARP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.10:FF:000021">
        <property type="entry name" value="MUTL protein homolog 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.10:FF:000024">
        <property type="entry name" value="RNA-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047201">
        <property type="entry name" value="ERI-1_3'hExo-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034351">
        <property type="entry name" value="Nrp1_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23111:SF40">
        <property type="entry name" value="RNA-BINDING PROTEIN INVOLVED IN HETEROCHROMATIN ASSEMBLY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23111">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00641">
        <property type="entry name" value="Zn_ribbon_RanBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="254"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="15">
        <location>
            <begin position="353"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="15">
        <location>
            <begin position="435"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="537"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="568"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDW95224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="625" mass="66167" checksum="DD1EBD292EF94ACB" modified="2019-01-16" version="1">MSSTTQSQQGNLDRYVVIHVATTCDEHGVYVTKDSAEVIELGWILLDAKSCDELHRESVLVKPINTPITPLCTSLTTLTWEHVRNAGTFRDAINRFDAFASEHLTSQNLDFSFVTLDSWDLRVQLPREARDKAVVLPPYLQHSRTFDLRTEYQRWQQHHPESLPFGPSMLSNICAALEVEPVQASAPIKHNLPFHLQALAPASPRRAMEEAVTLARVLRGLIRKSQPAHEHPDVLTRPMDARADVRAFLSERSKVLHMAGLPHDTTQSELESWFTQFGGRPIAFWTLRTPDQHKPTGSGFAVFSSHEEAAESLCMNGRALNEKAIEVSPSSSRVLDRAAEILTPFPPSKNRPRPGDWTCPSCGFSNFQRRTACFRCSFPAMSAGPSGDAMGGYGGGYGYGPPAMMPPPQHMGHHGGMGGHGGGRMGGSGGVVPFRAGDWKCGSEGCGYHNFAKNVSCLRCGASRAGAAVVADSGYPSPMDAPSSYGGGPGSFAGTPGPGPFASAAGGFNSNYGGQHFGGPPSTYALPSGLGASTGPYPSLNTHFGGGPAGGSHSAGPFDSRAAEAAFQSASNGPASAGPNSFYANQQESDPFAFLSSGIGNLSMGSGDARQNGGSAAHAPSKSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8TB90</accession>
    <name>A0A3D8TB90_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Long chronological lifespan protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_00851</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable component of the endoplasmic reticulum-associated degradation (ERAD) pathway.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LCL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8TB90"/>
    <dbReference type="OrthoDB" id="2234316at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23996">
        <property type="entry name" value="LCL2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034543">
        <property type="entry name" value="LCL2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38425">
        <property type="entry name" value="LONG CHRONOLOGICAL LIFESPAN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38425:SF1">
        <property type="entry name" value="LONG CHRONOLOGICAL LIFESPAN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017807008" description="Long chronological lifespan protein 2" evidence="5">
        <location>
            <begin position="22"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW95088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="120" mass="13481" checksum="93427DD0DF78D4BE" modified="2019-01-16" version="1">MTRLFSFVLAATLLMITGVQAQFQFFEQMFNGQQQHHQAPQNVPSDSNWYQSQFENAHCDNYLCPDTLACVSFPHHCPCPHPAFEEKIEFGDSKSICVSKGGFKAGEAARKVELARKGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8TBQ9</accession>
    <name>A0A3D8TBQ9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_00941</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8TBQ9"/>
    <dbReference type="OrthoDB" id="5339332at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW95178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="478" mass="51361" checksum="128CF7F88E974E5F" modified="2019-01-16" version="1">MASNAAPIGSPPQAQSTFTDGQAADDTLLSVARAPKLAHSTIEPNRRHSLPHHFLPPNLWSANTSSASLVETEEAARGEHVLDEATVAHRISALRQLNGSTKGMSRRYAKSTGARNSTFNQPVIVRTYSGAARPRSQRREPMATTKMNRWSGSSTGMTELKLPPVEAFSFKGIMDEIKHGVAEDLERIAEICARSRYSLSNQYEVHMPPHGRGEQYLQTVGVGTGLPANVVGPTLQAIGSDDEHSTRSIGKGSRGGKRARSAAYGTLETIMSSSRSSDEDKSKKKPAAALAEEVRGRAAKKGLEVPENAAEEAVEGDLNTAQPSKHVRSRSATFASIIIDSAQGFRHDAGPLTSPASLISEPARPQTSIAINLGKATGFEQAMFSPTLQALMSQKPTIIRNESSASSLVPDQRRRPSVVESISSWIPWRRLSSSMQAVPRTRLRSTSHAEANLRGLLEAAGNEGMKGKGRVNNSVVTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q3M2</accession>
    <name>A0A3D8Q3M2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_13126</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000026">
        <property type="protein sequence ID" value="RDW56485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q3M2"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="206"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW56485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="890" mass="101234" checksum="5314E7BDCB9A833E" modified="2019-01-16" version="1">MDALGKIFRRERAASSDLKQPTSSSVYRPLDQTKNEIRLLRIIPSTRHQGTRLSHKAASDIIVCELEYESLDEIEEDNRRRDAEESHENDLYTTAMRMLGQNTGPLVFDDFQDVRAHRAQQQLVYQWTGEESLRRGSKDDYHINSFRLTMLRVEYLKSLQIMTSWLPEQYQHLLQRNLTFEHWLQNLIRSPLSEHPDYAESTGLGYYALSYMWADLPFPLHDTNLRVVLKLAEAGGLGMKDLLKNTIPLKQKKIILNGRKVSVGENLYQALGALREIPEVRNGTRIWVDSLCIDQSNITERSNEVKRMDQIYSKADRVVSHIGTPDNHANEVLQIMELIGFATCDRDGADRLREWFRTQTNSPFFHYFALLMSRGYWSRIWIMQEIALASEKSILICGMKRYPLTDLLSFGKWQTQSTMPPFLPIRASPIGRAGLPSPNESGQPIMTLGTLMDGSARLKNIFELRQLIEVNQTRLEMFNTLWFRTAAENRASDPRDLIYGMLALLPAALVERIHVDYADSNTYQQVMIDFATSHIATYDSLHWILFRPWHSFPNCQEWPSWVPNLGLPFNASQFWWTIGDWRAYWGIDETRDWARNENGLLHCRGFKYDTVQQTTSPVLEGLVPDASVWTELPDFLEGYAKDPSLPAESLISSALPQTLNLSSSLFYNEIEGTTAVRSENPLDSCEHRYNDQEGLQAAVATCLDQLQLGTPTQPDAIFSIPIDVIHNALLYQAFLPRNTFGSPFIDSKDVGMQYLSSFLRHNENFSLWGARLADFFAAPCDDPTEFFMSATLPSFARPGRMPPVLDQTSQTARMFTTASGYLGVAPGDLRVGDEIFILHKCRMPVALRPSTGRPGAYKVLGGVFVHGIMQGDAVTGHLGNGQFVEDVTLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q450</accession>
    <name>A0A3D8Q450_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_13128</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000026">
        <property type="protein sequence ID" value="RDW56487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q450"/>
    <dbReference type="OrthoDB" id="3231000at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046873">
        <property type="term" value="F:metal ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045863">
        <property type="entry name" value="CorA_TM1_TM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002523">
        <property type="entry name" value="MgTranspt_CorA/ZnTranspt_ZntB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01544">
        <property type="entry name" value="CorA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144083">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW56487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="293" mass="34097" checksum="DF835570BA271555" modified="2019-01-16" version="1">MEEKKRVWIVRPEIVPSAVTISQIPLGDCFLERRFELPFLLPHDMDHIPRSLAEALQMLERVHAIVWIMVKPRVSESEPKDKGSILEPKTFFSTLEYAAVPDDATDLFLALRPMVLENHGTEPKLIMDLLRDAMLWVSLDTLFRDQIRCLKELCRSYEENRSAVLDENPEKAHSNEFNLTSITEAFKSTSTNTSMKRLSWVTFIFLPLVFVASIFGMNVDILQSNPSWWFYIPFAAGTAVLTLLVWLAFRSKHVERLFTRWTGWHNERNAWDEEKGLRKYTPQIGTTRKVKRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q4Z8</accession>
    <name>A0A3D8Q4Z8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12949</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000024">
        <property type="protein sequence ID" value="RDW56882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q4Z8"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW56882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="284" mass="30760" checksum="5254C12DD9247082" modified="2019-01-16" version="1">MRGKLNGSPLTITSVRANAIQAQHNVSRKGFSQSCNRGGDSSPPRETAYVHYNDSVQLPEEYEDLAVDYGILCSTNTAWGFENAGANDFHDGSAWAVDLDASGSTSGTTSGAFRLNQDDALCSTPILRPLEVSTSDSTPEIGSLESVPDIFISRPSLFDNELGHNDHGSISFDDFINFELSEPSSATVPTTTHSPRSSIVLNESLLRDLQSSHSPSPSQQLHPQESPEASLLASNLVLKRSSPNPALKLAMAPSSSLKCPICLKSLAFESRLRYICKNPTWKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q5K1</accession>
    <name>A0A3D8Q5K1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HET-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_12995</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000024">
        <property type="protein sequence ID" value="RDW56928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q5K1"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF13">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00364">
        <property type="entry name" value="DISEASERSIST"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="3">
        <location>
            <begin position="85"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="2">
        <location>
            <begin position="332"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="735"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="777"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="850"/>
            <end position="883"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="892"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW56928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1079" mass="122509" checksum="8AA7042AB6903BAB" modified="2019-01-16" version="1">MMHASIVARGCGSAAWGQHHHRQPEFNLHFRLNKQPRNIPSRRHVTHQASVLSLSLDSGQTMRLLRYDNDGAYSLVEFDEDVPRYAILSHTWGAEEVTFGDMTNGQGKNKAGYDKIQFCGDQASRDGLKYFWVDTCCIDKWNSTELGEAINSMFRWYRDAAKCYVYLSDVSRSPHNNDEIPNQLPWDSSFRRSRWFTRGWTLQELIAPTSVEFFSKDRELIGSKVSLERQMCEITRIHFKALRGNSLSDFSIQERMSWIENRSTTKKEDKAYSLLGIFDVSMAPIYGEGEEKAFQRLREKIKQALKGPHYEDFDVAFSLSNVSETQNFVARETELRKIHESLGGDGYNSRRIVVLHGLGGIGKTQLTVAYAKRYRENYSAVFWLNIKDEDSLKQSFTKIATQISREHPSASQLSSIDMTDGSMVVDAVKSWLSLPDNTRWLIIYDNYDNPKVPGNININAVDIRKYLPESYHGSVIITTRSSEVTIGHCIRITKLELLQDSLDILANTSGRDGLNTDPHAIRLAEKLDGLPLALATTGAYLKQSAISFSNYLRLYEKSWADLQKKSPELSSYEDRTLYSTWQLSFDNVKARNSLSANLLRFWAYFDNQDIWYELLQHSDYDKLDWIKELVEDEMTFENAVRVLSDHGLVEVEMSSQEQNESGGYSIHGCVHSWAIHVLNREWDYKLAKAAIKSVASHIPGDEAIRPWLTQRRLLQHAARCSFVVLNSLVTEDNIEWALHVLGNLYSDQGKLTQAEEMYERALKGYEKALGPDHTSTLNTVNNLGLLYADQGKLVQAEEMYERALKGTEKALGPDHTSTLSTGKLVQAEEMYERALKGKEKALGPDHTSTLNTVNNLGTLYADQGKLVQAEEMYERALKGTEKALGPDHTLTLNTVNNLGLLYTDQGKLVQAEEMYERALEGYEKALRPDHTLTLHTVANLGLLYKDQGKLVQAEEMYERVLEGYRKTLGSENISTLDTLSELGSLFEIQSNIARARIIYLEALVGYQKALGPDHPKSQGLHKKLRVLDTRAKETITINTREPINISQGETSRRGSKGILPESKRYKVLQKLGLHKALSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q647</accession>
    <name>A0A3D8Q647_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_12951</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000024">
        <property type="protein sequence ID" value="RDW56884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q647"/>
    <dbReference type="OrthoDB" id="438641at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053209">
        <property type="entry name" value="Gramillin-biosynth_MTr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47643:SF2">
        <property type="entry name" value="TPR DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G12710)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="300"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="378"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW56884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="661" mass="73399" checksum="BA92EFE384E7F92F" modified="2019-01-16" version="1">MPSRKSENTIFLTQQETERIQNTIQDRLKKCSELVGHAREPRIPKDAISQATGAALMADMGSVSGPTQEGTLPSFAVGQPYPPCTVSLQDLQPISLADLKMDTHHRGRRLAVKRVSPVVTLASRSWTMVQDQDGEEVERLEVCLHKSRFGEDVLESASAFVIKEPYFTLTDQGEATLRTDHPSDLIVRRDDIPSSNTAPTNGVNGHAENTAAENIARKCKDKGNAALKKHDIPLTHAHYTQGLKIASQERVSNTNPDLVRDISRNRALVNLLLNQLDEAEADSKASLTGRDDQRSKELDGKAYSRAGCAAYNLGKYQAAQGFFEEQLRLMPGDKEASVYLRKIALRLREQETGVYDLKKIKASLSRARPRVDAASFISNTEVRESPDRGRGLFATRDIPIGGTIMYEKAFCVVWGHESEALTAVTYDVRDEKIRISPVGLSAAIVQKLLNNPSQIGRVMDLYGDYQGTAKDVVRTEDGPVVDTFRIHDIMSRNAFGPGSQYGEEAANKASTGLWIWAAYINHSCIANAKKEYIGDLMVVRATRPIAAGEEIFHSYDESGDYDARQKALMTTWGFECKCALCAAEKLDDPAVRKKRQELARDADAFVAREPWADAKRLTIMKAQRLARALDDTYEGRPQYQGVPHVMAEKIHEWLAKASPRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q9G5</accession>
    <name>A0A3D8Q9G5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12415</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q9G5"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF17">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY FAMILY (AFU_ORTHOLOGUE AFUA_8G05690)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW58485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="241" mass="27693" checksum="2641854E1B6CAF85" modified="2019-01-16" version="1">MPLHLQPAIPSDASALTQIFFSAFHPEDPFEALIYPYGATPKAMEHGYKSIAKNFEDPNVYYLKVVDTEIAPDNKGSEIIAWARWKIWREERPQELWDVSWQLEQPDLSKAKDGVIDDVDVRVEQVFYDKLQEMRRKYIRDMSSLCTRPTQQRRGAASMLLKWGMNLADREGLDIFAQASPMILSSGGASSFGFEAVEAWYLDANMLGRDEPERNRWPLRKMLMRRRPSNKSSDGAETKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q9R0</accession>
    <name>A0A3D8Q9R0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_12340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q9R0"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF235">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE APDB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW58410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="510" mass="58245" checksum="B1571AF3C7C6562D" modified="2019-01-16" version="1">MSLLGESAKLEIWRSLTLTQWAVLVTLLHVLYKLVLYPFLLSSVRHVPGPWYTRMSRIPLQYAIYQHRRTSFATALLDQYGPIVVIAPDQVHTNDDSAMKIIYDRSSLKTSFYKSMGSWKGVTGTLGFIDYRTAAPTRNNLIECFQNRNLVTLDANIESHINNFIRLLDEKADQNEKVDGVIVFRFLALDIVTDVLWGEETRLLANSNHLNAQAFLRRFLAFSRWNATKGFIPGADTFVRLFGTKKWRELRNDCNDMDMTARDALQHWRDNQDGRHEKDVLSMLQAMNNGDDQTKIISSDDQIIAYMVEMLAAGSSTTSHTAAFVCWMLMRNDAAQMKLRSELRESFSDLASMDIKLTMDLPYLDAVIRETMRLFPMIPGPLERILGKEIVVDGNVIRPGVVASTAAYNQGQLGEVFPDANKWNPDRWLDSNDRMRLNWIPFGHGCRVCPGVNLAMTELKYIIGAVFRRFRVVIPLGHEDDMLEFADVFAAGSKTGHCWLKFDRLEQKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QBE7</accession>
    <name>A0A3D8QBE7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_12023</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QBE7"/>
    <dbReference type="OrthoDB" id="3525185at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DBAG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW59099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="493" mass="54544" checksum="85A72C4AE663A507" modified="2019-01-16" version="1">MVNNGASGACYACKQRHKKCDETRPSCLRCSRAHRQCPGYNASRELKFVNYAGETTCELAHQQSASLLHHSTHIDVHEWPAIKHNARSAFFNDYCITSKDQTLSRGYLNGLETMITKAGPTSEVAKACTIIALASLGKKVGDPMFLHAAENLHSLLLRSFRLSISNETASASVESLITAVLLGLYEIITSTDAYHGAHIAHARGISAILISKQSPFDLVCGGKLFQLSNPLPLEDLDLDNSGLQHLQYSLMKDTKVSPIFSVLCTPLVKQSNTTIESIFIQTASLILRARSLIADEATTIDQLYCLKLDAEQLDERYNAWSENIPDEWQPRSVGVITLKNDETTPPAGYWPGTISSYKDAYIASIWDGYRKARLMVLEIILDCYKRINTSHYLEVDSSIHKKTEELIGGIVSSIPYFLAADLQVFLKNSTTGTPSIVPGRPVGGLLLMNTLWALMTISMVEPRLKSYLKDCLAWVGNHMGLGQATILSKVRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QBG5</accession>
    <name>A0A3D8QBG5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Allantoate permease-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_12043</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QBG5"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000386">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="153"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="222"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="62"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW59119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="535" mass="60104" checksum="E5C0DD0D79C659D8" modified="2019-01-16" version="1">MRQAEKDDVGPNSRGAETGYISRASSQALVVKPIKSWKGYLWDTWELPPDQRWLLFKLDAFVLTFASIGYFLKNIDQSNVSNAFLSGMEEDLKMYGNQLVTSTSIFTVGYVIGQIPSNLLLTRVSPRWVIPMLEVGWGICTICTSSVKSYKALYALRFLVGLFESGFYPGIHYLLGSWYTPQEIGKRAMVFWLAGSVGTLFSGFLQAAAYTNLDGVQGLSRWRWLFVIDGIITLPLAVSGFVFFPNLPQSGKKTWWTTEDEHVLSIKRMEAIGRAGKQPWTRAKAKRILLSWHTYLLPLCYVVWNNSWMQPAMGYWLKSFNKTPAPVPGTTYSVAQINDLPLPTTGIFIVVAIIWGWLSDAFNGSRSPFIYAGAVITIVFSVLLRQMPLYENIHGRMVVYWLSNIGNGAGPLILTWINEICADDTEKRALLIAMGNDFAYIVQAIAPNFVWKTTDFPAAKKGYLWSIILQALLIVVTVTIQLLLWRDKRIAAAKAASDIENESSLLNTDSQDLKARDIDEKKVVRAEEVALVRLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QBT9</accession>
    <name>A0A3D8QBT9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_12163</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QBT9"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF32">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="423"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="53"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW59239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="490" mass="54119" checksum="77B012C037995FCF" modified="2019-01-16" version="1">MKLDDPKGPVSGCVAALGQRSTDGDDMSYVGVVLPDWEPAEEKKIKRKIDLVLLPIVIFAFFTLQLDRGNISNALTSTITKDLHITTNQINIGSQLFNVGIIVLELPSNMLMQRYGPRNWLSVQVFAWGLIATLQIFMKGYKGFLSTRLLLGLCEAGFVPGALYYVTSWYKKSETSFIIMIFFLGQNFASATANLIATGLISLDGKANLAGWQWIFLVEGILTISAAAVFYLFLPPAVGNGKPLISMGSWSYFTESESHIMINRVVLDDPSKTAKNVRITAKDILYTLRQPKLYLHVAITMLSTAATHGLTIYTPSLIKSFGFTTTEANALNSVWAYGAMILNGILAFSADRTGHRGPFVLIAATWTLTTYSCMNTVRHMESKWRKYAVTILANVPYSTPHVLNVGWVSVHCKTPAQRSVTQVIIIMSASLGGIAGGQTFRSDDAPLYTKGFRQVTYMAAGLWASTAILTIWYFIEGKYMRTKQTPDLEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QC04</accession>
    <name>A0A3D8QC04_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7702 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_12185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QC04"/>
    <dbReference type="OrthoDB" id="2560628at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056119">
        <property type="entry name" value="DUF7702"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109">
        <property type="entry name" value="UNPLACED GENOMIC SCAFFOLD UM_SCAF_CONTIG_1.265, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24800">
        <property type="entry name" value="DUF7702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="2">
        <location>
            <begin position="8"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW59261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="263" mass="28917" checksum="F405BA978BD52AC4" modified="2019-01-16" version="1">MLDPAGVFTYRDGVAVIQLFFFAIFLCFAFVLCHRHGFRRSAGWVILIPFSILRLLGAGFQLASINHPINSVYGGALICEGIGLAPLALLNLGVFGRLNKFVGKVHDKIFTLISLTAIAGLVLGIYGGIDSSESANLGTNDLLKAAVICFAAAYVAFACLFLVFLLQWRLIPITERPLLLCFAYCAPFMVIRLLYSILPAYVPSLRSQFNALIGNVTTYLCMAVLEEIVIVACYIFVGMRLELLPEELKSPPLSFKKKKKNPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QE37</accession>
    <name>A0A3D8QE37_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_11691</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QE37"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF9">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="67"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="337"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="650"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW60085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="732" mass="82239" checksum="DB3DAC1ABCA2B457" modified="2019-01-16" version="1">MSDDTDLFISFIESLHNTEPAMPGERPAKRIRQACEPCRRKKSRCPGEKPTCSHCTRLRQSCYYAEEPHRRSNVSEAPQLARTEVQPAAATTDSRLEDRLKFVEAKLLEVLSNQSATTTPRIPPRQVSFSPAATVAAIADPPQGTSSPSSTKRPLLPSSSLPPWDMKIWAAQKYLLYCDCQPLALFHRDSFIATLGDRDSEVMFAILALTIRFSEDSPFYGDCGELAAGYAEAARVIVMQSVSQGTVELSTLQSLCLLSLIDFSNGNTQRASVHSGLAMSLAHNAGLTSESPLYLTDKVREERRRCFWSLFLLKRLHGADFSVLDFSGEENFPWYPETTGKPVNSARAADRPSPPRLDTDPPREHMQDKGVVAYAIQLSEVWFKTTRYSRRRGKPSSLPPWSPQSEYSIILAQQMDFETRMPYIHRFKPAEFSKKSAEDLHANRDYWGPWLFIQFLYHTNLCLLNHPLLLSLRLRNFKCVIPEIFLQHTADLIASHASWILHFIDMLQAKSFKVTDPFLAHCVAIVATIYLQESFSEDFKIRDEKQAAFTKCLKFVRDFGQQWPHVDRMADKLQRLGETVSSTYSTSSDSPQRPTRSLLIDLGQFWEILEYSSSSEIPSKSSILFGSSLYSGVRRHTAEMAHTSALPEPTRVDRQDFDGTGPQNTPAAGVTPAHEPRDSSGAIAAESGVTPLMFSNDELAVLTESFFHQRTNDFEGGVNVSGVEDWWNSGNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QEU3</accession>
    <name>A0A3D8QEU3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Sterol-4-alpha-carboxylate 3-dehydrogenase ERG26, decarboxylating</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15 16">C-3 Sterol dehydrogenase ERG26</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13 14">C-4 decarboxylase ERG26</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Sterol-4-alpha-carboxylate 3-dehydrogenase erg26, decarboxylating</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BP5796_11853</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BP5796</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="10">Heterotetramer of ERG25, ERG26, ERG27 and ERG28. ERG28 acts as a scaffold to tether ERG27 and other 4,4-demethylation-related enzymes, forming a demethylation enzyme complex, in the endoplasmic reticulum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QEU3"/>
    <dbReference type="OrthoDB" id="10058185at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000252">
        <property type="term" value="F:3-beta-hydroxysteroid dehydrogenase [NAD(P)+]/C4-decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000346">
        <property type="entry name" value="C-3 sterol dehydrogenase/C-4 decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0752">Steroid biosynthesis</keyword>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="17">
        <location>
            <begin position="16"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00046995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00067470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00067985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00081267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00081397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00081452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00082106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDW60247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="375" mass="41375" checksum="CC22C94FD906DA4C" modified="2019-01-16" version="1">MAPTPAQSKKPLGKALVIGGCGFLGHHIVNLIHSSYDAQISVIDLRTTNNRRPDSDGVQYFDGDITSLSSLIPLFEKIRPDVVFHTASPNLMGSSKEMYKKVNVDGTKCVIEACQKTGVKALVYTSSASIISDNATDLINADERWPVIRGKMQTEYYSETKAEAESLAIAANRAEAAPKLLTAAIRPAAIFGSGDVQLIPRVLDVYYQNKSGFQLGDNTNLFDFTHVDNVAHGHILAAVALLQTSTLTTPPLDHEKVDGEAFFITNDAPVYFWDFSRALWKAAGNTKGTEHVWVISKDMGLMIGGAMEWINWVLGKTPKLTIKQVKYSCMTRYYSIGKAKMRLGYSPIVSLEEGIRSAVQWYETERMKEGEKKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QF25</accession>
    <name>A0A3D8QF25_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF5672 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_11864</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QF25"/>
    <dbReference type="OrthoDB" id="10025998at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043729">
        <property type="entry name" value="DUF5672"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18922">
        <property type="entry name" value="DUF5672"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5672" evidence="2">
        <location>
            <begin position="116"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW60258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="298" mass="33600" checksum="41863BF6A320F527" modified="2019-01-16" version="1">MIDQYKYSPLVATPAQRRKPGSVAVALVTLLAIYMIMFTIPKFPSVHSPGDNSTAPPLITTKVATIIEDRPLDTLVPLLLHFSSVLGPEWPIILYTSQDILPISRPFQRAINESRITIRALPSEVHFTSQESVSDFLTKPWLWEQLAPAEHVLLFQADSILCSNSALRVDDFLEYDFIGAPINPSYGQGYNGGLSLRNRTMVLDILSSSSWKDEKASAENPNDPAIAFEDQWFYNKMVEHGAVLPSMDVAQTFAVETVFYDTPLGYHQVERWQAENIEKIDRWCPEHRLASKDLIISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QI10</accession>
    <name>A0A3D8QI10_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_11375</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QI10"/>
    <dbReference type="OrthoDB" id="18915at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22749">
        <property type="entry name" value="Otubain_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.60">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1300.20">
        <property type="entry name" value="Peptidase C65 Otubain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019400">
        <property type="entry name" value="Peptidase_C65_otubain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042468">
        <property type="entry name" value="Peptidase_C65_otubain_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042467">
        <property type="entry name" value="Peptidase_C65_otubain_sub2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931:SF15">
        <property type="entry name" value="UBIQUITIN THIOESTERASE OTUBAIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12931">
        <property type="entry name" value="UBIQUITIN THIOLESTERASE PROTEIN OTUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10275">
        <property type="entry name" value="Peptidase_C65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="OTU" evidence="8">
        <location>
            <begin position="133"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="481"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="481"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW61483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="510" mass="56354" checksum="27A4853E77CB0196" modified="2019-01-16" version="1">MFQPQPTPYSPFSSYGLIGSAPGAAAGFNYEQHRSPSVVDNGGPTVFRDPVFRPSSGLPSAFHTLSPPPRFKMEAPNPADDLDRQEAMAREYKPNLEGPLVGEKKSSVAIAEEYAKADPVYVAKTAHLPQTYSHYRQIQGDGNCGWRAAAFSYFEILVQTGDKAKIEEELARMTSFGNLLANVGGFDAWLCEDMSGETLDLLKDLASIPNQTEAMALVLEKLNDRSISDTIVYHLRMLASSWLRADPGLYQGFIQGPEGLDGYCKEMQAVNQEIDHLGMTLLIDVLLKPIGVAVEIVYLDRSEGTQANTHLFEPTDSNGVPTHPCAPRIYLLYRPSHYDILYKEITALPIRHDLQVNRATSFSHQHAVQNTTGISNFSSVDMSAILGIPGFSMQPMHNLPPTYPYSDFAPSPMSPSISPITAAVPSPPAEFPLCQKTLLQLPVSVGTPTSFRPSKYNWEAASEWQDTPTFQTNTFKNSHYNTAHYNNSNFQPEQWSPENEEPSTSRKKTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QIK8</accession>
    <name>A0A3D8QIK8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_11555</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QIK8"/>
    <dbReference type="OrthoDB" id="5595695at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.520">
        <property type="entry name" value="Amidohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.90">
        <property type="entry name" value="Amidohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10910">
        <property type="entry name" value="Amidohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="49"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW61663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="436" mass="45647" checksum="7722A86E9F488593" modified="2019-01-16" version="1">MATAITNVRIFDGESVLSDTHLVIKDQKILSIGGTIPNDAIVIDASGGTVVPGLLDSHVHTQPEQLRMALRFGVTTELEMMGFWTADSRKAVEEDDNMADLRTAGFGMTAPGGHPSELIGPLKKTGGLPPGTGKSGLPGNNESLKGRKPGPAENAHGPGHNHRHEAPTVSSPEEAVSFVADRVTEGSDYIKIMIEEGSVFDAPGLPLLSNDTVVTAVKEAHAHSKLAIAHALTAEATTQAINAGVDGLAHLFIDGPHTTELLQNIANSGAFVTPCLCVNASIMGRSPKHLTADIRITSKMSPAWQTTLAGSLNTYPQGNIEQVLATVGALHKAGVDILAGSDASFPVPHLGGVAHGVSVHHELQLLVAAGMTPIEALKSATALPAKRFGLSDRGKIAPGLRADLLLVDGDPTRDIGETLNVKDVWRRGKRLETITT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QJ25</accession>
    <name>A0A3D8QJ25_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_11562</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QJ25"/>
    <dbReference type="OrthoDB" id="25921at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="65"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="19"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="271"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="24"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW61670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="844" mass="93134" checksum="7E20A97C6EBB24E0" modified="2019-01-16" version="1">MDGDSNSLTYSAHLDTDALVTSPIPSPTPAPTQPPIAAPAPVPVPVPPPATSSTEKRKQKKVRSACERCRYKRVKCDGQVPSCGNCSKAGALCVDVDSHDAEKKMMRGSSEYVAARIAWLESIIRTQLPHINLDDHYFAQINLQGQPELLGRTPGIANNLPLFDLTQPHPSLSSITVSDTVQEHATSASGVGSAVHPDPTVRGTKRPLAAMDVESPFRVESIDQDARSVALELGLLSLNSNSRQVHYLGSSSGSLFAPLLFPRKSGTSLWTDPSRLGSSRDTSSGKARMEAQPGMHTASHTSEMEKINLPPREECNILLSRFFGHMHPNHPFLHRPSFTCAVDALYHCAAAPEKASFQYNGWPTNIPPFPYNGEEYILQGQKLITISAHVAAFQLLIALSIGATLQIRSRKYTHNPKAFFNSAISISNHVFDSISLPVLQAVLLTIVHSLIDPDGCDAWTLTHIAMAHAVDLGIHREVSRSSDRFSPTSIEIRRRVFYCVYSLDCSISTIQGRPLGLGDDTFDVQLPDLSKRQSQSMDSQNSSDELADTATLSYSIQSFKMARFISRIKSTFYRLPVYIGNLDGGQDFTCIQDQLRDGLGQWLAESLEAVTKDVSADQRLRLTTKLQIQYHGAMCLLHQPSQVIAHPNDSSLQICFSSATKRLRLFETLYDSGALCHSWRTVQDIFLAGATVMYCVFISLAVRQSVSVSTLSRDFRACSSMLSVGGEWWPTVRKAKFSLERLSNHILDMLAETSRSDSAELRLGHQPFPQDYIPPNMLGWPEPETLGFNGIEQTLLNLINHNGSLIDIFDATSMNGLLDGIPEQLQTNHRFDTTIWDGFEQVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLH9</accession>
    <name>A0A3D8QLH9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_10870</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>myo-inositol(out) + H(+)(out) = myo-inositol(in) + H(+)(in)</text>
            <dbReference type="Rhea" id="RHEA:60364"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17268"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLH9"/>
    <dbReference type="OrthoDB" id="6339427at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005366">
        <property type="term" value="F:myo-inositol:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904679">
        <property type="term" value="P:myo-inositol import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000073">
        <property type="entry name" value="MFS myo-inositol transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF22">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="43"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="296"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="48"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW62568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="536" mass="58263" checksum="55905A29FDB023F4" modified="2019-01-16" version="1">MSLHHNVPAKDAINVQQIENFQEPSSDMKSRNLDSIEDTTPGAFIWLVAAAAALGGLLFGYDTGVISGVLVVIGNDLDHKALSSSDKELITALCAAGALCGAVIAGATADKYGRRPAIWFASVLFTIGAIIQATSYTIIQMAVGRFLIGLGVGSASTVVPLYIGEISPSRFRGRMISVDMIFLGGGSVLAYALDAAFANVAHGWRYMVGLGAVPSILLGVFMFWCPESPRQLLYHNKREECISVIRSIYPNSSDEMISDKVLSIEAGVTYSKSLNEEVSVLKAFGSLFGIPANFRALTAACGLMFFQQFCGFNTLMYYSSTLFDIVGFKNPIAVGTVVAGVNWIFTIISILVIDRVGRRRLLLWTMWGMPVCLVLAAIAFKWVPIDQATLKLTNDKVGWPAIVVLVSMIGFVAFYAAGLGCVPWQANEFLPMEVRAMGTMMINIFNWGPNIIISSTFLSMMKGISPSGTFGFYAALCFLGWLFVYFCFPEAANMTLEEVRAVFQHGFGVKYAEEWRTQQKADVRLQKEAASSATSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQR4</accession>
    <name>A0A3D8QQR4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">quinol--cytochrome-c reductase</fullName>
            <ecNumber evidence="3">7.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BP5796_10619</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a quinol + 2 Fe(III)-[cytochrome c](out) = a quinone + 2 Fe(II)-[cytochrome c](out) + 2 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:11484"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="7.1.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="17">
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </cofactor>
        <text evidence="17">Binds 1 heme c group covalently per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome c family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.8" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQR4"/>
    <dbReference type="OrthoDB" id="5925at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008121">
        <property type="term" value="F:quinol-cytochrome-c reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.760.10:FF:000002">
        <property type="entry name" value="Cytochrome c1, heme protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000003">
        <property type="entry name" value="Cytochrome c1, heme protein, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.760.10">
        <property type="entry name" value="Cytochrome c-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036909">
        <property type="entry name" value="Cyt_c-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002326">
        <property type="entry name" value="Cyt_c1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021157">
        <property type="entry name" value="Cyt_c1_TM_anchor_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266">
        <property type="entry name" value="CYTOCHROME C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10266:SF3">
        <property type="entry name" value="CYTOCHROME C1, HEME PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02167">
        <property type="entry name" value="Cytochrom_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00603">
        <property type="entry name" value="CYTOCHROMEC1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46626">
        <property type="entry name" value="Cytochrome c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81496">
        <property type="entry name" value="Cytochrome c1 subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase), transmembrane anchor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0249">Electron transport</keyword>
    <keyword evidence="5 17" id="KW-0349">Heme</keyword>
    <keyword evidence="13 17" id="KW-0408">Iron</keyword>
    <keyword evidence="15 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="7 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="136"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="137"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <feature type="binding site" description="covalent" evidence="17">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>heme c</name>
            <dbReference type="ChEBI" id="CHEBI:61717"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00029351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR602326-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RDW64117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="318" mass="34780" checksum="E054E89263ECFD6C" modified="2019-01-16" version="1">MLARSSCLRAAGAVRNGAVTVSKRAASTSTTEAAASPFRLNLAGGAATAVAIGSAAWYYHLYGPTAHAMTPAEEGLHPTKYPWVHSEYLKTFDHQALRRGFQVYREVCSSCHSLSRIPYRSLVGVTHTVDEAKAMAEENEYDSEPNDQGDIEKRPGKLSDYLPSPYTNDEAARAANNGALPPDLSLIVKARHGGCDYIFSLLTGYPEEPPAGAVVQEGLNFNPYFPGTGIAMARVLYNELVEYEDGTPATTSQMAKDVTEFLNWAAEPEMDQRKKMGMKVIIIGSALFALSVWVKRYKWSPIKTRKIAYNPPQMGGKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQW3</accession>
    <name>A0A3D8QQW3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transcription initiation factor IIF subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_10560</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TFIIF alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQW3"/>
    <dbReference type="OrthoDB" id="76676at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005674">
        <property type="term" value="C:transcription factor TFIIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001096">
        <property type="term" value="F:TFIIF-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008851">
        <property type="entry name" value="TFIIF-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011039">
        <property type="entry name" value="TFIIF_interaction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13011">
        <property type="entry name" value="TFIIF-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05793">
        <property type="entry name" value="TFIIF_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50916">
        <property type="entry name" value="Rap30/74 interaction domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="130"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="367"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="420"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="421"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="462"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="490"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="520"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="543"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="626"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="656"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW64058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="735" mass="79757" checksum="BB8E5F14E9A1A75B" modified="2019-01-16" version="1">MSASPSGMSNGRTPTPNAGPGGAPQFIRKPKAADPLRPRTKKPVRRPNVAPGTNGAASGKAPAEKAFHGAGQGLFPRPKPNPNLPKANGGWTHAPQGEYHDFPLVTTKRALREGLRHHIARFTAKRDVDPADQDEFTRPLALHRRDPRQPARGEAPKEEAPVPGEPMDSKEKEKLEILKAEKEARRAADLAQIAPTGNNAAAAVKKPQAFRNEKTTQVHRLDKTAQQKKESDLRYEEALPWHLEDADNKNTWVGNYEAALSDTNVILLVDGGTFRMVPLEKWYKFTPKNQFKTLTIEEAEAQIAKKTKESRWVMKTQEKQKKEEEDANNRRAAYGLYTVKSESNTFKNAKRETQDTDDLDFEADDLFQDDDEQVTMEPDKDEDVKDSKDRIKREMLGANLFGEADEGEVDQELDAEEKEALRRKKLGKGVKKALKKREQNLIYESDSEHPYSSSSEDDTSDEEKQAEIDRKKDEEAKAKAKLESSKAPSGTSSKGTNTPSGRPKHSDPLMRNKLKRPGSPNLSETEASGNESARKKHKKKHGQSSSQATGSSTPAPGTRPLSPTPGGQPQSPRKSSLVKLSMNPSKLADIQSSPPNPSPTGAMSDGEATGGEMSDGAGGKKKKIKLNYGKGSPSGSRAGSPAAGRSGSVGAGGSRAGTPASQGPSGARSPGSGPLQVSEVIAAIPSTGTSITDLMKKFAGRVGDKKGEQTDKKEFIKMVKENSVYGPDKLLRPKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQY4</accession>
    <name>A0A3D8QQY4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nuclear control of ATPase protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_10721</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQY4"/>
    <dbReference type="OrthoDB" id="413313at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013946">
        <property type="entry name" value="NCA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28234:SF1">
        <property type="entry name" value="NUCLEAR CONTROL OF ATPASE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08637">
        <property type="entry name" value="NCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW64219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="672" mass="75747" checksum="E0187E27D01E18AE" modified="2019-01-16" version="1">MSIVADQVRKVDSQLDRVHLVPHSSRDGISTAESQRVISSNRIIQLQSLVKALSTTSSSQPLLSSWRIRTLLEQAALSENITTMDDDEGDEMETDHATVAYQKELEWLLVSKATVQTYGLLLNTLLEQTIPLNDDIWYWDEVLGSYTYTGLYTIQTSPLRLWAWTQDIYRDTRKRVARLGRSPNDAMSTSDIGTSLTARWKQFYGLVRESIRERSVADIQQKVLSPIARCRTKARINQAKLRRLREMSASGLGVLMDEGLTFDIDDEIADVAKTDATESHEWKGVVERSVALMDTVLCHVTTLETGVSEFEDVVFASVADDPEIFSRNADTFSRSRPAKVAQRLQHILTVHVPKHLENTNQLALVYGRPSKLVRYWLPATVLLLSSTTILRILVNRKAEIGAWIRDFGATIRDFWINWVVEPTKKIIGTIRHDKDSEVAIMSKESLKGDRDSLERMVVDFAIDNPEASGLGTSPLSDGQIAEIRAKVKEGDLTPVLRAYEKDLRKPFQGTVRGDLVRTLLIQVQKTKVDVEIAISGIDALLKSQELVFGFVGLTPGILVCVAAFRYFGGVFGSRKGIRQGRKARQTVRVLRNIDRILTLATPTQNNILSYKDHGLLLCEIHVLRERATGLFPGEIEREFLEDVADLCNINSGISTQQKVLDRIRWGYSKWLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QR43</accession>
    <name>A0A3D8QR43_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PRA1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_10683</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PRA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QR43"/>
    <dbReference type="OrthoDB" id="63113at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004895">
        <property type="entry name" value="Prenylated_rab_accept_PRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317:SF0">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03208">
        <property type="entry name" value="PRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW64181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="176" mass="19226" checksum="F8FBE7F70747303E" modified="2019-01-16" version="1">MSRINIPLDVLTSRFNLSDRFASVRSQSLASRFANLKPVSEFLDLKRLSKPANFGEVQSRVNYNLGYFSSNYAVVFAMLSIYSLLTNWLLLFDILFVVGGMWGIGKLDGRDLDVGVVRATSSQLYTTLLVIAVPLGILASPISTILWLIGASGVSILGHASFMDKPIDEAFSGEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QR47</accession>
    <name>A0A3D8QR47_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7779 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_10774</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QR47"/>
    <dbReference type="OrthoDB" id="6161812at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056681">
        <property type="entry name" value="DUF7779"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35205">
        <property type="entry name" value="NB-ARC AND TPR DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35205:SF1">
        <property type="entry name" value="ZU5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25000">
        <property type="entry name" value="DUF7779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7779" evidence="1">
        <location>
            <begin position="179"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW64272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="372" mass="43147" checksum="1C41828638BB1502" modified="2019-01-16" version="1">MSAKLAASFSRFSVELGLRDNEPENPHSVAKYMREWLEKTKNWLLVFDNAASDENEKLLQEKEDLIKIFRSECNHGSILITSRDEKLIRKFGGVELRQLNEEDAVELLITRTKVDQANFNQSSIDEEIEAARRIFENTDYNPLGIIGISDIIRRDSTRLTDFYASYSNQHSLNTVWRRQFEKLNKDALNLLNMMAYLDPDRIQLKMLRQCSGVSHKKDLEIISSPRKFDHLRSTLIQNSLVSYNEELQELRVNRPVQAYCRSRMTLQDRCKSFKLGVAIVKQSWPSQTRGIMYDPALLPGRIDYLSHVESLCQHYTRSLDGLDSPLIPEDKVNWEFPSILYEAGWMCYEKGLFDLAQDLLGLGGGFFRFTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QR97</accession>
    <name>A0A3D8QR97_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Acyl-CoA dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_10733</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QR97"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013786">
        <property type="entry name" value="AcylCoA_DH/ox_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF17">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G16630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02771">
        <property type="entry name" value="Acyl-CoA_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3 6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase N-terminal" evidence="9">
        <location>
            <begin position="33"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="8">
        <location>
            <begin position="157"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="7">
        <location>
            <begin position="262"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW64231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="434" mass="47202" checksum="D7855147FC045EB5" modified="2019-01-16" version="1">MTAPSPTQPSAFGCSSPYAEPLWYSRDISPHYTDSHRRLRAAVREYIDEEILPYAFEWEEAGQVPAAVFKRHADLGYLALSTDLENVPLPCGIPRKEWDEWHTLILTDELSRIAYTGVLWGLGGGNSIGVPPIVNFGTAAQKQRFLPGVADGSIRFCLGITEPDAGSDVANIKTTAVRQGQHYVVNGSKKWITNGIWADFVTAAVRTGGAGAAGISLLIIPLQAEGVTRRRMVNSGVGASGSTFITLDDVRVPVENLLHGENRGFEVIMSNFNAERKSLATAALRLSRVCAEDAWRHACARETFGTKLIENPIIRAKFVKMGRCIEPAWAFLEQLTWLIALGEKGPGDAVRIGGMTAMLKIVSTRCLEKCVREAQQILGGLGYARGGKGGRIEAISRDVRVMAVGGGSEEIMSELAIREETKDLRKYADGTSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUA9</accession>
    <name>A0A3D8QUA9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor Iwr1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_09963</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IWR1/SLC7A6OS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUA9"/>
    <dbReference type="OrthoDB" id="6255506at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040150">
        <property type="entry name" value="Iwr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013883">
        <property type="entry name" value="TF_Iwr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28063">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN IWR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28063:SF1">
        <property type="entry name" value="RNA POLYMERASE II NUCLEAR LOCALIZATION PROTEIN IWR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08574">
        <property type="entry name" value="Iwr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor Iwr1" evidence="3">
        <location>
            <begin position="318"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="256"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="134"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="309"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="360"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="408"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW65271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="449" mass="50105" checksum="5E61AB3205D42B8F" modified="2019-01-16" version="1">MSLPPATILIKRKATDEPIDYFRVHESAGKRQRRGEDYVFTRQPTQEALNVDTPLSTPPGVRRIKAIHRSTSSQSNLAKVTQSASQDTSASNQGQPGTRSSHDPPAVNVRLPSPVPGPQSVQIVPPTRKFHISRNPTSSVTPQNLTGDAAGRKRGNKNETIFVERRTRRKVAEDSGKASAKEGSAQAIFTQASDIRPLKKPGLAARSSVSRVPSQTQNETVNPARVRVPSAFSDDFVAQMQAYTLQEIGHSIAQADSFSSASSSPSVTPRKTQKSKFTPKPPNLRYHERHPESVPPKQSSDIDMHPYASEEDEDDDSEYIIETYVRVPADSMDTDEAPKAYGLLVLDSQPDIDEFYRNDEDSDEEEVDEEEDENAENHYSADYPDEEVDSDDEYNRNAYNYRTHNASDLEEFDEDDATFSDEDNDATKYPWMKKSWTAKQGVHIDADDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUR0</accession>
    <name>A0A3D8QUR0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_10285</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUR0"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW65593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="288" mass="32880" checksum="7E7D2A67189832F0" modified="2019-01-16" version="1">MSGSVRFDEEAGEALLKDSSDRVLFVKRKTHRSYEIVMPWALASFFFCTTLFFAWKSSVTTSEQHGIYAALGSYEEGFATDFGIIPFYQSDFLIDLVQVSLHPKIPINVLQKRFTNDLLYNTTSGKFYNQPLSFNETKYIGEPQSTVDDAWQQLLHAQYVAMDPEEVKQIPESHISSIWYDGEHEFFELGVFHNLHCLNEIRRSLAGNSHGNTRDILLESNIHLDHCVDQIRQALMCHADLTPVPMHAIGVAADHFSLGNGEMHTCRDFDAIWAWVEERGKKQRALGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUT4</accession>
    <name>A0A3D8QUT4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_10112</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUT4"/>
    <dbReference type="OrthoDB" id="1735038at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070008">
        <property type="term" value="F:serine-type exopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000251">
        <property type="entry name" value="Extracelular serine carboxypeptidase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000368">
        <property type="entry name" value="Unplaced genomic scaffold supercont2.8, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008758">
        <property type="entry name" value="Peptidase_S28"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010">
        <property type="entry name" value="PROTEASE S28 PRO-X CARBOXYPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11010:SF117">
        <property type="entry name" value="SERINE PROTEASE 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05577">
        <property type="entry name" value="Peptidase_S28"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017793334" evidence="6">
        <location>
            <begin position="21"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW65420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="567" mass="63220" checksum="5981B586B2210CF8" modified="2019-01-16" version="1">MIARKNVLVLLLGLLGAATALGPARVGTNFAIERRLSSTTFGTRSLQKRDIDPSLLYPEHNLSVPIDHFHNSTRYEPHSDGMFNLRYFFDASHYKSGGPVIVLQGGETSVTDRLSFLQKGLLQQLVQATNGIAVILEHRYYGSSWPVPDLSTENMRFLSTEQALADEAYFAQNIVFPGLENHNLQAPGTAWIGYGGSYAGGFNAFLRKLYPDVFWGTISSSGVIEAIWDYWTYYEPIRVYAPQTCISNLQKLTHAFDNILIKLNDSASTAELKTAFGLPNVTHDDDFVSVLSYGVENWQSKNWDPALNSPDFDLFCGNISAPGIIYPATAGLNSTVHDLLTKGGYGSETSTLTNPMLNYIGWLTGYAVDSCSSENQDECFGQHNFTYYAQDDLSQAWRSWPYQYCTEWGYLQTGSGVPADQLPLISRLIDLKYSSLVCEGAFNITTPPDVELVNKYGGFNISYPRLAMIDGEWDPWRPATAHASPFNNTAVNRTNTVSEPFILIDDAVHHWDENGVFPNETVDTPPNFFPPLTITNTQAKEVQFVTAWMAEWAYLQKTKDLAPLEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QXS1</accession>
    <name>A0A3D8QXS1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QXS1"/>
    <dbReference type="OrthoDB" id="3552865at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW66592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="325" mass="36259" checksum="0E5E481CFE83460C" modified="2019-01-16" version="1">MGPPKLLFSVTKRHSSPDKRQQCKKRQVVPGCLIQTFSILSGVLWLVAASIIVVINFKVSGKCKSNLSHVGQILKAQQLAKMDSNALGVLQLVAKALEIWFVAIEASLVFILVKTVARRTLRPALPLRYIFIHSTLGQFLALGTLLFSDPLEMRFKRPLKQIRRKQSRQDEGLLQKSKDKKSNWLWHRSRLYLSSIFIVLGSITCSLMGPATAILVLPNLQWTEINKNTRSPPMWLDSLQAGQPPHDILVPGCEPSNVTSGNFSCLLGYYRAFINSLAATAIPTGVQAMPHPISFPPQKSLNVIPILQEGNVTLRPNDSLWFLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QXZ1</accession>
    <name>A0A3D8QXZ1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_09396</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QXZ1"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="403"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="414"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW66647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="429" mass="47704" checksum="F7B2EDEBBAD23EAF" modified="2019-01-16" version="1">MPDRDVSGMKEDLDIQANEYTYMLMCYTIAFAIIQVPANLVALKLRPRICLVVCEIGWTIFTFAQAGAQTPGQMYAFRFMIGLFESGFSPIIIFLLGCWYTKTELAKRIAVWHITGFFGSATSGFLQAGVYASLNGHLGIAGWRWLYIICGCMSLPVAISVWFLLPDYPHNTKAWYLTEEDKAMAMRRSANQGKANITGTLDLKLLVRMFGNWRWWVLCAMYIFYGNSCQANSYFAIYLKSAGYSVAARNLIPACSNIVSMVTDFAWGFGSDWTGNRAYWAVGPLLCTTVIGSSLLTAWPAGNVSKVVGFFFVSGGYVTSVVWTWANEINRGNAEERALTISSMNGLFYATNSFLPILIFPQTTAPNYPKGFPSILAFAVVACILILVTDFLHRRQLRQEAEVKAGTPPAEMTEESKSDQEVKIASEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QY22</accession>
    <name>A0A3D8QY22_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_09426</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QY22"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF236">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW66677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="34888" checksum="566CF7B37CAE7598" modified="2019-01-16" version="1">MRAVITQLFPPRPTYTEENVGSLKGKVFIVTGGNQGVGLELVKILYAKGGTVYIAGRSPTRIAAAVDTVNSIQTSSPGHVKTLALDLGDLTTIQPCVSAFLAQESRLDVLWLNAGVAQLPAGTTTAQGYEVHMGTNCLGPFLLTKLMLPLLVRTAKTSPKASVRVVFTSSGIIDMTGPPGGISLAELVPGHYSQDRGHNYSASKAGNWILSSEFDKRVGGDRVLCVTQNPGILNTTGWGAMSWAIRLLISPLMHPPKMGAYTELWTGLSPDVKAEDGGRLATAWGRWHPSPRQDILESMKTKAEGGTGVAAQFWDWCEAQTKPYAGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7J2</accession>
    <name>A0A3D8R7J2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_08422</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7J2"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF12">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="86"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="176"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="277"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="411"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="51"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW70025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="555" mass="59087" checksum="68B70D31CE456817" modified="2019-01-16" version="1">MSSTTLPGEQTPPTMASSLDLEKLDAELPASSVPEAAEYVRPISNVRWYLVCLGLYLSALLYGLDTTIAADVQGPILQSLGEIEKLAWVGIGFPMGSVSIILLVGCCYGLFDIKYLVISSLTVFEIGSAICGAAQNMNMMIVGRVIAGMGGAGMYLGALTYVSIFTSVRERPIYNALIGLCWGSGAILGPVIGGGFAVSSATWRWAFYINLPLAAAVAPIFFFLVPNFNPAPDRSTREKLAQLDWVGAILNAAVFTIFQVVLTFAGSTWKWDSAGPITLWIVLGVATILYAVQQTFSIFTTPEMRLFPVQFLKSRTMLLLYFATAACSTGLSIGVYYIPLFFQFTHGDSAIQAAVRLLPYICLVIFCIMLSGALLPVFGRYQPFFVLTGILLVVGGALMHTVTASTSPSTIYGYEVLMAIGAGLSMQIGYSIVVVKVAPHEIAAAIGYMNVAQIGSMAIGLSIGGSILQNRGFINLRDALSAYHFSEQELRAALGGAQSVILQGGDAQVRTLAIEAIAKTLQSLWVLTIVAGAVALVSGVFMKREKLVLAMTAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7K2</accession>
    <name>A0A3D8R7K2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_08416</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.9" evidence="1"/>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7K2"/>
    <dbReference type="OrthoDB" id="2924818at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009288">
        <property type="entry name" value="AIG2-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935:SF0">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06094">
        <property type="entry name" value="GGACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma-glutamylcyclotransferase AIG2-like" evidence="5">
        <location>
            <begin position="20"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="20"/>
            <end position="25"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW70019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="182" mass="20097" checksum="4C8E8E1D9709CF24" modified="2019-01-16" version="1">MAAPTPASQSQSQSQPPRLYFAYGSNLSLTQMLSPTTGRCPTATYHSVGMLRHWRWLIGERGYANIVPSAADVVYGLLYTLQPADERVLDRAEGVPWAYQKIAMQVSSLSGLAALERECEVEALVYVDGLRLGEGVIWPEYVARMNRGIGDALAKGVPLEYVEKYLRPFVKEEGQGEVDEEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7R1</accession>
    <name>A0A3D8R7R1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08388</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW69991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7R1"/>
    <dbReference type="OrthoDB" id="2504919at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="47"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW69991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="659" mass="75127" checksum="943758C1DA3E8739" modified="2019-01-16" version="1">MDRLYDTLHAQIRLLRISQQAGTKDAPADLHFELAYFSLRSPKCPKYHALSYAWGKTGEHPIFLNGVKVLVRDNLYNFLVQASTIDAFGQESWWWVDAICINQNDSAEKPSQLKLMGDIYKEATKVIVWLGVETEQSRSAADSIRHLYDMRWTWDTDDDLQFRKLRTSNQVDWAAVQNLLLLPWWTRVWTLQEFLLAKKLVFYWGRHPLEGDVVRSAMFATYLAGGADDRLIDKAAFDAGWNRRRMRQFKEAVDDGKIPVRMRLVAMLAYIGDSDATDPRDRLYSLLGLCDQADRQLVKEPDYELPVEELYTNLVISFVKKFRNLDIICFAHLFRSRDPSRNLVPSWVPDWTVHVRCEPVPVMASQSATLHIGNFRALGSIPGTARYNASKDLEPQVHFMTDVRWTTGAEGAVISDDVTLLLCRGIQLDTIDGLGGMVKAVSKEKEECIQSTEVKNLPRHKRGRRTISSRDSDILDVLVQSLVLDRSDRYLDHKLGSRDKTFGEEFLAACHGDMKTSATIQGQWKEWYALNKDLLIRGASFQERVEKFKTSETLLTSGRCADTQHTDSFIARWRDTVRTMSRRLMVTADGNIGMAPAAAKKGDIVCVLFGCSIPVVLREGNNDGTYALVGECYVHGFMEGEAIADWKAEYRDTRIFPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R865</accession>
    <name>A0A3D8R865_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_08518</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R865"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017719182" description="Carboxylesterase type B domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="2">
        <location>
            <begin position="38"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW70121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="230" mass="24774" checksum="3639E787D8243AE4" modified="2019-01-16" version="1">MRFSLSVAASLAVVVSAVPTSRTITPSPTVNILNTTFIGNVSGGIESFYGVPYAQPPVGPLRMKRPQPLSAYASPTVRATATPIACSQLGSTSANVVQGEDCLTVNIQRPSDLNSTAAVPIFFWIFGGGSERGYTARYDDSGLVEKSMELGHPIIFVSVNYRTNIFGFLGGREVQADGVSNLGLRDQRLAMQWVQDNIAAFGRDPTQVTIMGEISWVDFHSFAHHYRGGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8E8</accession>
    <name>A0A3D8R8E8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_08598</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIT1/WOR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8E8"/>
    <dbReference type="OrthoDB" id="5319641at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018608">
        <property type="entry name" value="Gti1/Pac2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28027:SF2">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09729">
        <property type="entry name" value="Gti1_Pac2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="403"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="403"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW70201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="467" mass="50952" checksum="10EA1F3CF0989A4B" modified="2019-01-16" version="1">MGSSPPLSPTFQGHIASTQDALILFEACLSGHLNHVARRPHDRERASLIKSGNVFIYEEHSSGIKRWTDGVPWSPSRILGNFLVYRELERPFPPGEKKRAMKRNKRSPGITKAQDPYDRNPSVNGYSSSAVTSTYGGQNSTSSISKETERSLIGSLVDSYGFKDEGLVKKTVSVTVGGISHHLVSYYSVADVMEGRLPNPSKDPRFQHVIPRQDLITKQNFRTPIDEVDNMDSNDASAYGSYSYPRTGYQMTNQSIAHRQIPLPTPPMSAYPSSTSGVFGNYSMAPNSGAYHEALPAPSAPYGNQFSAGPGVYSGQKHDSYEHGPFRAQRFNSVIGISSDSSRAPMPAVSTNYPRRSSTAFEQSSSMDSAISGISSASVDSKMSNDSGYMSQGFYGGSLRDTNSTPQTFTPQRSLPTPTQQTFDRHSQGYPHLDSASKEHVWPMGNASAGHGHYLTHQQPWASTGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8I0</accession>
    <name>A0A3D8R8I0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_08752</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8I0"/>
    <dbReference type="OrthoDB" id="5819582at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF134">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="371"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="415"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="453"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="483"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="107"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW70355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="530" mass="60512" checksum="352D493596DC0A09" modified="2019-01-16" version="1">MVAFQVLTGYIRNLNPFAPSSPSQFRAQDIEATQSRPFLSAVDAWTPTCEASFEYITDEKPEPIAVSPAFVDRLWKVLFLLIPLLPSFVHPFFSGTPNQATRIHPTSWVDGFRGFASFFVFIYHFAEPFHNRLPYGFGAPGFEDDGTLSTTAEGLVNVSIMKLPIIRLVYSGQAMVSAFFVISGFALSYKPISLLRERAWDRLFMSLSSAAFRRSIRLLSPMVISTAIPVVLLRLGIYELFRPYNAGLPYRFPTFIEQFWSWLTMTGKGMDFLNPSYAFDWNSYGPQTWTILVELKGSFVLFLLVLALCRLKVYVRFLILAAMCYHCVRTGLWEIFCFISGIILAELNQIRQETADDQLLGARFKSNKSPVLSAVKWSGIFIMALYLLSSPDKRADVTPGYMLLSVLNPLVRHDFRFWHIMGSILLIWSVGCSKPLQAIFTNDFAQYLGKISFSLYLVHFFVVETLGYSLVKTFWGLIGDNTAFKYELGWCLSFVILLPIVIWIADMFWRAVDMRSLTLSKWLETKWCKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8L0</accession>
    <name>A0A3D8R8L0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_08782</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8L0"/>
    <dbReference type="OrthoDB" id="5378633at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF110">
        <property type="entry name" value="UBID FAMILY DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="28"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW70385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="311" mass="35293" checksum="F33966A59DDDF72F" modified="2019-01-16" version="1">MVTLAQRQLQTAEVSIWILLSSAATLLRLTSQRIQRGGINNFRVDDWIMVFVFFLNLADGGAGLYAIFEMNLLGALDSESSEEVMAKYIRIAHYFYVPGEMVFQLKLWLLKACLVILYWRLTVQSKLRHVVTAAGIYCIVSYLVVVLFLLVFMCRPFSGFWLDIENAPTSNCVTWLPYYKVQLPMNISSDLLIFCTPLALFSGSTLPWKRKILLCGIFSVGAIVMLFAILNKVFLYQDSTNPEYILWSYRECNLAVIVTNAPMCWAALRRIFGLKAFSEESGNVRELNIKTGDSECSPWNSKRHSASAARP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RC84</accession>
    <name>A0A3D8RC84_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_07693</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RC84"/>
    <dbReference type="OrthoDB" id="3559670at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW71659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="79" mass="8726" checksum="6B2A67D1CC94ADC0" modified="2019-01-16" version="1">MRSQEAAFKASRKPAKKPKQVVEQHPAATPQKIVKNASRNERRKAARRVASLLRAQKALEEAVAAEAPLDEPEPETKDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCH1</accession>
    <name>A0A3D8RCH1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Exonuclease domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_07759</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RCH1"/>
    <dbReference type="OrthoDB" id="5087660at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW71725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="21625" checksum="0087A21368D49C01" modified="2019-01-16" version="1">MSLCLQKLRGNLMLSGKWMYLFSRIQQDPTILVFVDTESGLIDNADIHQIGVVRLDGMIRAYKALRKTYGPPVSKPMRGISAVAALQKLHDSGLSRSMIWMEHSVGHFDYRRIAKITPTNLQHSLPLIENVYSTLDLWRDVFLGPFAHKLSHIFQLLHPHDPLLDRRHFALPDAFMCRALFKAIFELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCP0</accession>
    <name>A0A3D8RCP0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative facilitated glucose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_07695</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RCP0"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000474">
        <property type="entry name" value="Sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF13">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="212"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="274"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="432"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="463"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="116"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW71661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="614" mass="68288" checksum="78E70962ECCDB342" modified="2019-01-16" version="1">MSEKVDPDIAFASQNEHVAKAGEALGGADGHHRSRALNIVENPLQRSSPEKAVVDAHAFAETHGMAEHAALFGRAALVARDPDRFEMVTELEEQERHALAYERDHKWHGPFMLWYSIALCAMGAATQGWDQTGSNGANLSFPEEFGLTGKGRDEWIVGVINAIIFLTAGLIGAFIVDPLNHYLGRRGEIFLTACCLTATPIGSGFARSWQGLFAARFVMGIGIGAKNATVPIYSAEMAPARIRGALVMFWQLWVVAGIFLGFAANVIVKNTGKIAWRLQLGSAFIPSFFLLIGIFFCPESPRWLMKHGKIAQGFQSMLRLRANPIIAARDYYYSYVIYEVELQEAQGSGYFSRLRDCFTVPRIRRANYGATTVMLAQQMCGINIISFYSSTIFENVGYTATEALYASLGYGAIQVVFTIPTLFLIDTKGRRTLCLITFPLMCIFLLAGGLSLLNTTGSRAEKIGPVVLFVYLFTICYSLGEGPVAFQYSAEVFPTIQREQGMAWAVCINNTFAGILSLTFPRMQTVMTPTGAFGFYAGLNLIAWFMIFCFVRETKQLTLEEIDQVFSVPTKTFLHYELTEWLPWFVRRYILLQRVPKPAPIIEKAERFETVKSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDJ8</accession>
    <name>A0A3D8RDJ8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Adipose-regulatory protein-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_08084</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDJ8"/>
    <dbReference type="OrthoDB" id="3990054at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23995">
        <property type="entry name" value="Seipin_BSCL2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009617">
        <property type="entry name" value="Seipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212">
        <property type="entry name" value="BERNARDINELLI-SEIP CONGENITAL LIPODYSTROPHY 2 HOMOLOG BSCL2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212:SF0">
        <property type="entry name" value="SEIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06775">
        <property type="entry name" value="Seipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="297"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="369"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW72050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="417" mass="46580" checksum="984D84505814B10D" modified="2019-01-16" version="1">MVRSCGTKSDENHEADVYMSIQEYIKKPYRVATSKPARQTYLNTALFMITSTILLGLAIVAYVLFYIQYVPQTSLERIIHLQYGDGPHPYGIVNLGTSLISQQAYDISLSLSLPRSPPNLKQGNFMLSLSLLSPSYRPPTTIPGPPTTLEPGPSSSIAPSDILHISRRPAILQYESALVSYSSRLAALPLYILGLRREAETLTVSMAERTEFSRGWKNVPSFALLELQAGQEVQVYDVRVHFVARFGGMRWLMYNHRVLSFITFTTMFWLSEVLFTALGWLALRTLFSGTSAGAKRRKIKREGEGTDTTETIKKEEETDEPELSDTPRNFPTYGRQQPLRFVPKIKQEDEQTGTGSEEYVLDETQIQPLVADEEDNVDYDDFEAGGFRDSGVGTSYSDAGAAGGRGLNRRKSRGGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDR7</accession>
    <name>A0A3D8RDR7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phosphatidate phosphatase APP1 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_08223</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDR7"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019236">
        <property type="entry name" value="APP1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052935">
        <property type="entry name" value="Mg2+_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28208:SF2">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE APP1 CATALYTIC DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09949">
        <property type="entry name" value="APP1_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017682281" description="Phosphatidate phosphatase APP1 catalytic domain-containing protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidate phosphatase APP1 catalytic" evidence="2">
        <location>
            <begin position="277"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW72189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="513" mass="55345" checksum="2B4BFB41C83A85E9" modified="2019-01-16" version="1">MISPLFFAALLPAALAAPAPAPAQAPVPHPMITPPARLEDRYVLQRRGLLSEITSLGGAAESYVSSVLGSYPAYVESGVANFFQGFPTGTDVQSSLGISDSDLAATPTQALNIPGYANWTDQGWNLRFRGNIYKQPNISESKLDDLANVFLVGTSIQALPSSQAVQARNLTAEIFVVQQGNVNVSFHLEPATSAGGDGEANGGGAVTPAGGAQNITLVGETTVEGDFDQFIQIANVSGAGGYLAPGNDTTNIQRLNVYTDGTLTGNATSYLVPTAGITIISDIDDILRVTKIYEPAEGLLNSFARPFTPWMNMPELYANWSASIPDFHFHYLTTTPEQVTRNYMDFIYKTYPGGSFDTRPLNFSDVSATLSIRKFLLTKIFQTYPQRKFILIADTSNSDVMTDYPEMVTDFPGQVQCIWLRNTSATDSGDKFPYNTKGFKGLNQSQYMFFLVPDDLKNLDVMNGQCYNSSIPQNVSFGYQGLPFGLSNGSSRLGGMSSWGMLIAGLLMLGALL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RHQ9</accession>
    <name>A0A3D8RHQ9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_07031</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RHQ9"/>
    <dbReference type="OrthoDB" id="3358371at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF26">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="30"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW73589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="355" mass="39448" checksum="48F51418FF389525" modified="2019-01-16" version="1">MSKLLVIIGVSGNQGSSVAEALLVDLSWKSLQEVFKDANLVFGNTAFDAAPIIFPTEESVAKLKPGQTAGEFALDKELQQGKNIADAVASMGDSSELFMWSSLSDSKKWSGGKYPGIYHFDSKSVVVDYIKEEYPDLTAKMSLLQLGWFVTNWKLGRVAVPWEKQTDGSMILRIPGSGDWPWPIPIVQPADTGEFVKALIKLPPGTELLAYGELMTMTEYMNLWSKATGVRATLVCATVDDHDKLLPGWGREIGETYAYMQEFGYWGGKNVDNAFQRFGPRSQHYKKMLMLYLTSKLRDAVCPDEVGEAQLGLGERIAAVGDLELPLKLGAGEDYLPDDGGEWDDFKEFRRWFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RID9</accession>
    <name>A0A3D8RID9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hpc2-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_07261</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RID9"/>
    <dbReference type="OrthoDB" id="5576775at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014840">
        <property type="entry name" value="HRD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08729">
        <property type="entry name" value="HUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hpc2-related" evidence="2">
        <location>
            <begin position="509"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="459"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="569"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="583"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="622"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="657"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW73819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="667" mass="70166" checksum="1648F807BE5513E2" modified="2019-01-16" version="1">MAPSDRSTRHEELGVEGDGTPYSRQYSSSPGLSSPPRSSPEAPDAISRQLAKESASRQESSITVATSADALPSTAAAPPVKERKKPGRKPKIHYNPDGSIQDPQPRRRAPRKPKDPNAPPQPRKRKATTSDAMNNSENRSASGKQPRLSDPELPTPETKFAVPPNVAVTQNGNNDGIPITSFFSPAPPAPTSTPAPAPAPAPIQTPTPIQPQQPPPPVVRSSGQNYDPIRSNYDPVRETVVTNNSYNNSQASPQAPPYVPNRASESPSISSLVDPPHQAMTSPSIATQSFFNQQQQARLQSDGRTSIPASPTTNRLVPSPQVIPSPAPSPAAPIAATAAAPIAPVKKDVPPPTAPVAGSKKSTAASSTAASPKPHKTKDKERYPTPPPLPGSGLMQLGGTDGTEFRAPTVCFEVKIAPGEGNKYVNFTRIAEERYGWDALHPRLAAQRERLARVAAAGAALERSGNKESGDEASDDSDSENDIEMGGMSDSRIGTDTGEKKVVRKRILKEDMYDKDDGFVDDSELQWEEQAVAANDGFFVYSGPLVPETAKPEAESAPKRGRGRSRGGTTRGGGPGSRGGRVSGAAAAAAAAAAAANGTPSARPASGPGSRGGAVTRKPRITKADRARMEQEKLEREKMGTLATMPTGYQGMPLGSNLGTTPMVFNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJ92</accession>
    <name>A0A3D8RJ92_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Conidiation-specific protein 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_07440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJ92"/>
    <dbReference type="OrthoDB" id="4158609at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW73998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="87" mass="9136" checksum="7E048F05F506805E" modified="2019-01-16" version="1">MSANTKMSAVNGGTGSIGTPANNGANNVGGTRRASQEGTMFSGLMNHKRNSQDAAAAARRQSFNEMKPAPGFIGQMWQNFTQGSDKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJ96</accession>
    <name>A0A3D8RJ96_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_07557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJ96"/>
    <dbReference type="OrthoDB" id="5307922at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051288">
        <property type="entry name" value="Serum_paraoxonase/arylesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799">
        <property type="entry name" value="PARAOXONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11799:SF20">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW74115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="37397" checksum="9CBEE8E1CD06B6FE" modified="2019-01-16" version="1">MIVLECNMSYYRPVSTSGLIENRGGCSGLVKIPVRDGDGVPILDIDNPQSDGLYNLQALTPTGSYTNSQYGLKENLDMLGFDVEILADGTRRFYMVNHRPPISKSGVPLDAKKLGANSTFEVFDLEKGGSELKHVRTIASEAIIVPNSIAADGKGGFYFTNDHGSKIGIRFDLEFLFGTGSIGYSSPPASNSGPRKCNIVSSGGFYFPNGIVLGHDGLIYVAHSAAGKVSVHKPKPSTPGLEKVAEIPLKVTLDNLSVDTNGDIFAAAMPHVFKTLIATSSKGNGGAAPAAVWRIPRRGLEDEEMLFEAEKILEDGKAKVLPVMTIAVSDAETGRLFLGSASDGFVVVCAPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPE8</accession>
    <name>A0A3D8RPE8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_06647</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPE8"/>
    <dbReference type="OrthoDB" id="10253125at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000002">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000004">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_uS5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_uS5_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718:SF4">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="RIBOSOMAL S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="9">
        <location>
            <begin position="88"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="15"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW75826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="265" mass="28864" checksum="4425877F5CE1E4EE" modified="2019-01-16" version="1">MADRGGARGGGFGSRGDRGGDRGGDRGRGRGRRGPRRGANKNEEKEWQPVTKLGRLVKDGKIKSMEEIYLHSLPIKEYQIVDFFLPKLKDEVMKIKPVQKQTRAGQRTRFKAIVVIGDSEGHVGLGIKTSKEVATAIRAAIIIAKLSVLPIRRGYWGTNLGLPHSLPTKESGKCGSVSVRLIPAPRGTGLVASPAVKRLLQLAGVDDIYTSSSGSTKTLENTLKATFVAVGNTYGYLTPNLWKETKLIRSPLEEFGDVLRAGKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPG4</accession>
    <name>A0A3D8RPG4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Heme peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_06605</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homotetramer.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPG4"/>
    <dbReference type="OrthoDB" id="823504at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20612">
        <property type="entry name" value="CYP_LDS-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09817">
        <property type="entry name" value="linoleate_diol_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.640.10">
        <property type="entry name" value="Haem peroxidase domain superfamily, animal type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019791">
        <property type="entry name" value="Haem_peroxidase_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037120">
        <property type="entry name" value="Haem_peroxidase_sf_animal"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050783">
        <property type="entry name" value="Oxylipin_biosynth_metab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034812">
        <property type="entry name" value="Ppo-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903:SF13">
        <property type="entry name" value="LINOLEATE 10R-LIPOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11903">
        <property type="entry name" value="PROSTAGLANDIN G/H SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03098">
        <property type="entry name" value="An_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00457">
        <property type="entry name" value="ANPEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50292">
        <property type="entry name" value="PEROXIDASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR619791-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW75784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1155" mass="129224" checksum="FD6713C93ABBAC79" modified="2019-01-16" version="1">MKRLSSVFNSKKSDKEKRKEPNDTNGLKGSNSVNEVNGTNGTNGHSTLKKFAIQPNRRKSSLGVVPQKSNPVSDPSDGPDHSVNREGVASTLNKYAQAIAFSARPMPTETGDGEYITEPEQTGLWDDLKAMRIKDFETLDMTLKQELSSTKLTDDRSMLMERTIQLVSNLPPHSKNRVKLTNTFVGTLYDSLAHPAQSQLGDKYNYRQPDGSYNNIHFPEIGQAGTAYARSVRPGIVQPMPKNDPGVIFDAVMSRGNGGFKPHPNNVSSMLYYIASIIIHDCFRTSHEDFNISGTSSYLDLSPLYGSSQEDVDNMRTFKDGKLKPDCFSEKRLLGFPPGVGCILIMFNRFHNYVAEQLAVINEAGRFSTPRDGLKEDKLDAAWLKRDNDLFQTARLVTCGLYINVILLDYLRTIVGLNRVSSTWTLDPRVEMNKDETPRGLGNQCSAEFNLVYRWHSCISERDEKWSEELYQKVFGKDHKDVGMHELLMGLGKLEASLSDDPLGRDFAGLERDSDGKLNDDDLVKILTESIEDVAGASGANNVPEVLRAVEILGQNQARAWRCATLNEFRKFFGLTPHKTFEDINSDKEVAAKLKALFDHPDFVELYPGLVCEEAKKPMDPGVGIAPTYTISRAILSDAVALVRGDRFYTVDYHPANLTNWGYKEVNYDLNVEQGCVFYKLFTRAFPNHFTFNSIYAHYPLTIPSENKKIMTKLERADDYSWDRPARIPGRINVASYDGVTTILKNGDVFGVDPWRRGLYFLMGKPGADFMLAGDGPFFAERRTQMKQCLYQDNWHKSVKAFYQDITLSLLKQWSYNLHGTTKQVDIIRDVGNSAHVHFAANIFSLPLKSNAHPKGVYTEHELYGILALIFIVIFFGDVDPTKTFPLRAACLPLCQGLGQLVEANVDIINKTGIISGLIDPLIFPEHNALKDYGVHMVRHLLKGELGVHETTWSQILPTAGAMVANQAQVFGQIMDFYLGPGKEHLPEINRLAKTNTPETDDILLHYVMEAIRLNGTFGAYRKCKENITIPDGGRTTSFKAGDSVFVSFVQIAKDPKIYPDPESVRLDRPIDSYIVYGIGPHSCLGGEASRVALTAMLRVVGRLDNLRATPGDQGHMKKIPRPGDFYVYMDALQSSYSPFPTTMKIQWDGGFNEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPQ9</accession>
    <name>A0A3D8RPQ9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_06757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPQ9"/>
    <dbReference type="OrthoDB" id="4491390at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF11">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="25"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW75936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="42599" checksum="14CED9EA946C4A54" modified="2019-01-16" version="1">MYWTAAAQESTLRQGKDQIPDSHSRSPGSRRPSLRLRSLSLPSVIEPGSLQYGRWAVEVPGLSHVQEEEDPNPNSVDDDVPVSPHQAPAAPYKEPPQTKRALRWIVLTGAAVVECPLDHMLLHRISPLPSEHIRSTAVLIDYCVPNASYSTSTKPLSWMHVLPDLPGVTETLRLAVSALMHARVGSVERRSDIAKDGLRLYIRALEALRRTLKQSAGALSIATFAATLILALYEMLQPTGDATSWCKHMDGLESLLQARGPGQHVAGASHHLFVGYRATGVTFISCPSKPSSLTRSWRKTVATGHHSTESYFPGQHRMADRSMEHPAQKPLSRAARPRYRAPGDSRKDRQAPSPQPQPTCLSPTTMRHHGPVGPEREVPEMGNRLGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RQ45</accession>
    <name>A0A3D8RQ45_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative L-PSP endoribonuclease family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_06911</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RQ45"/>
    <dbReference type="OrthoDB" id="309640at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019239">
        <property type="term" value="F:deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803:SF48">
        <property type="entry name" value="2-AMINOMUCONATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11803">
        <property type="entry name" value="2-IMINOBUTANOATE/2-IMINOPROPANOATE DEAMINASE RIDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW76090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="150" mass="15995" checksum="836403E83D249F8F" modified="2019-01-16" version="1">MASPNGTAYFLPPTAAQGLANYPHARTTPSSSKTLFVSGISSRRGDGSYAGCVTAADGTHTLDVAEQTAAVLENIKTVINGATEGKCGWESIIDATIFLTDMKDYARMNAEWNKVWPDKSKAPARTCIQVAALPNERLCIEIKCTAVILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RQ94</accession>
    <name>A0A3D8RQ94_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_06875</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RQ94"/>
    <dbReference type="OrthoDB" id="5421421at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW76054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="341" mass="38163" checksum="8C185B476231904D" modified="2019-01-16" version="1">MAETSYQGSSGRQQTYAQQEWPALTPYSAVSSFNLPAQYDTSLITPIQNMVSPAIPPRTRPITIKHESVSPATVSPSYDLWPTNDGYSNLRPKSPMKYKVRGDNGPSYHQPRITTAEADFPPSPFFCQAPYFGSFTVSAGCTSSPQSISAATTSPIMARNNEWEGLENFSGLPNIVPRVGTYNRSQAPLLIAPSPSSRKNSSRTYFEPQRQNSTTSDYSTPQTSLPSEDTPDSSPRSTQSSATIMRQQDETSPSQDLEDDNREGPSRNGQNSMFLETQFIVQARLHDRLPWKQVTENFNRRFKKNMHTPALEMRLKRHRDRARMGSDTDVSITPSLRITPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RQL5</accession>
    <name>A0A3D8RQL5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_06995</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RQL5"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW76174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="192" mass="22172" checksum="500023ABA7624466" modified="2019-01-16" version="1">MLITDSVPPNVRFEIDDLEEPWTFSQKFDYIHCRDLIGGFSDWPNFFAQSYQNLEPGGYLELQSLSLPCQCDDDTLLPEHYLWQWSNYMLEAAKILGRSLDIPSSYKELAEEAGFINVEAKMFKWAQNTWPKESNAKELGMWELENATGGLEGISMALFTRGLGWAKPEVDVFLAKVRTDMRNKSIHAYWPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVB7</accession>
    <name>A0A3D8RVB7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_05871</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVB7"/>
    <dbReference type="OrthoDB" id="1739143at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF1">
        <property type="entry name" value="ISOCHORISMATASE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="4">
        <location>
            <begin position="89"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW78019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="280" mass="29927" checksum="4978F6DB64EEB432" modified="2019-01-16" version="1">MSIPLRHSIIPTTPHPHPVSSYKENNRLTAQIFFNQPQEISIATVSATLSSRTSSTTASMAESLSTHPSAENYVGSGFNNPMGWGSRPALCIIDVCTAYWTPGSPLDISSNPAGAASPASMRRLLAAARGANVPIIWTQVKYTSPTMADAGLFYNKAKALSVWQEGDTRGLDACVEGLEPKEGEEIVVKKYASAFFGTDMATRLQVLGVDTLVICGVSTSGCVRATTLDAMQSGFRPMVVGEACGDRTEEVQRSNLFDLNAKYADVVTEAVAIEKLKAGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVX4</accession>
    <name>A0A3D8RVX4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycerate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_06071</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVX4"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050418">
        <property type="entry name" value="D-iso_2-hydroxyacid_DH_PdxB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43761:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE CATALYTIC DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43761">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G13630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="37"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="148"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW78219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="35345" checksum="0C8F529E5F8B92AE" modified="2019-01-16" version="1">MADTNPLKIVHLDCIHVRPPPTFNFPHIYTEYPTSAISEVTYRIQGADVIITCRVPITAAMLKLCPTVKMISVMAIGTDIIDLQACKERGIVVSNVPAASNESVSEHAISLYFAVKRNVVCCHNSLLAGDGEEWVRRGTSIGFFAAGMPGTCKDDTMAIFGAGELGNRVAKIGSALGMKVIFAERKGVPVEEVRSGRVEFVEACKTSTVIMLTCPLNASTKNMIGAAEFAVMQKNTVLISVARGGIVVEEDLVDALKSATISGAATDVFMEEPAGKSNSVLIREAANLEGRLTLSPHIAWFATSSREKLNRVVASNIEDFIKGTPSNTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWL9</accession>
    <name>A0A3D8RWL9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Leptomycin B resistance protein pmd1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BP5796_06295</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03249">
        <property type="entry name" value="ABC_MTABC3_MDL1_MDL2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000102">
        <property type="entry name" value="ABC multidrug transporter Mdr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000009">
        <property type="entry name" value="ABC transporter B family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000251">
        <property type="entry name" value="ABC transporter B family member 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000302">
        <property type="entry name" value="ATP-binding cassette subfamily B member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="102"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="766"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="816"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="884"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="916"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="998"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1030"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="106"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="431"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="770"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1094"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDW78443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1338" mass="145949" checksum="84D881EB244EBA22" modified="2019-01-16" version="1">MASELSEKAVQPSSSSTDSNSIDGHRTNAKDNIVKGVEEKAGSENGTLVKLDSKIVQVKNSDEDLYKHLPPNEAAILKRQVDTPELNIGWRALYRYSTRNDILIIIISSICSIAAGAALPLMTVIFGQLAGTFQTFFLGTSSRNDFNHTIDHMVLYFVYLAIGEFCTIYISTVGFIYTGEHISGKIREHYLEACLNQNIGYFDKLGAGEITTRITADTNLVQDGISEKIGLTLNALATFVAAFVIGFIKSWKLTLILSSTVFAITAAMGAGSSFIVRYSKQSLGSYALGGSVAEEVISSVRNAVAFGTQDKLARQYDMHLAEAEKWGKKNKMVLAVMIGCMFLIIYLNYGLAFWMGSRYLVSGEIALSSILTILMSIMIGAFSLGNVAPNIQAFTTGISAAAKIFYTIDRASPLDPSSEEGIKLDHVDGEVELRNVKHIYPSRPEVCVMQDVSLVIPAGKQTALVGASGSGKSTIVGLVERFYDPVGGQVFLDGHDVSTLNLRWLRQQISLVSQEPTLFGTTIFENIRHGLIGTKFEGESAEKQKALVINAAKMANAHDFVTGLPEGYETNVGERGFLLSGGQKQRIAIARAVVSDPKILLLDEATSALDTKSEGIVQAALEVAAAGRTTILIAHRLSTIKDADNIVVMQQGRIIEQGTHTQLLESRGAYYNLVEAQKIAAVNELSAEEQAAIDEADDKLVRQMSNNSEQFAADPDDKNIAGKLSRTQTQKSQSSMALAHRQTQAVPEASLWTLMKLIASFNKAEAYWMLLGLFFSILCGGGNPTQAVFFAKEIVSLSKPLTEAKQIRSEVDFWSLMYLMLAFVQLISYIAQGICFAFCSERLIHRVRDRAFRTMLRQDIEFFDKEENTAGALTSFLSTETTHVAGLSGVTLGTLLSVITTLVAAIVVSIAVAWKLALVCTATVPVLLGCGFFRFWLLAKFQQNAKKAYEKSASYACEATSAIRTVASLTREKDVLDNYKQSLAVQAKKSLKSVLQSSLLYAASQSFMFLCIALGFWYGSQRIASGEYTMFQFFLAFSSIIFGAQSAGTIFSFAPDMGKAKQAAQELKLLFDRKPTIDAWSNDGTSFEKCEGTVEFRDVHFRYPTRPEQPVLRGLDLIVKPGQYVALVGASGCGKSTTIALLERFYDPLAGGIFVDGKEVSSLNIRDYRSHIALVSQEPTLYQGTVKENILLGADRGEVTDAQIEFACKEANIYDFVMSLPDGFNTVVGSKGSMLSGGQKQRIAIARALLRDPKILLLDEATSALDSESEHVVQAALDKAAKGRTTIAVAHRLSTIQKADIIYVFDQGKIVEHGDHSELMKKGGRYSELVNLQSLGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWN0</accession>
    <name>A0A3D8RWN0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_06063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWN0"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW78211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="142" mass="15418" checksum="9F64A54C5A7D50DD" modified="2019-01-16" version="1">MTPRSIDAIVTRIKDIFTPSCERKPNSPKCSSAITTNNTTTPKLSDAAHSIRSPMSYSYDSDSESLEDSMPMGKRKSPVQRRISTSDWTKIARSHNKSMADLERLERVKGLVESREAGGVGGVSGGRSVGVGSRRGSFVDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWQ2</accession>
    <name>A0A3D8RWQ2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_06364</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWQ2"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="304"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="371"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="409"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="437"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="504"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="570"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="603"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW78512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="703" mass="75325" checksum="C8C9B02A1BF95B10" modified="2019-01-16" version="1">MDDLPPPPYSVHDTNPPSSAQYPTSPFIGRVVIDRSEQGPRRSQPVSNTSLPDTPVPVGTPTPAQAPNFSVSDLEHSGFVSASPYFELRQPLGPRPAQILTAPLNIGPGVSVESIPFPHPANIWEQRGIDQQDWITFLNHLKPVNDTQSRAPTRQKDLELLSEAGQQDALYPSQLRPNEDGEKARLHHVKIKATIAQWNHGFFLPRSVEVIPVFGSNASNAQRLGHRQAGGYQIASSSDRASGWASRLGSMFGIETPTPVQPVVAHSSPQEETLLHNAISKGSRSIAKMLLEQGHEDIEALNEKGETVLYAAVCRGEKGLVQLLLDHNADPTAHPQGSNLPLYIAATRDRKSILKLLLKRSTAGINEISTDGETALFRCVRRSYSSCAELLLESGANPNIRQHGEVPLLHIAAKKGEQSLMKPLLKHGCDVEEKNHEGDTPLCAAVKRSATSVVKLLLQHHATVSVRSGNGEYPLSIATSRGNTSIVSLLLAQPDVEIEVRDSAGLTPLHIAIARGDTSIVTRLLRESASPDMFPTGAEPLLSTCVSKGNTSMTHLLLESGANPNIQNSAGLSPLAVAVNKGDVSICSLLLNKGADPDVTFADGDSLLYRCVLKGNTSIVHLLLESGAHADAQGGLGERCLWKAVEKSNTSIVSLLLNRGANPSATSLLGETCLQKAVARGDTSIVHLLLAKLPKAGVDEKVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWR3</accession>
    <name>A0A3D8RWR3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycoside hydrolase family 43 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_06222</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWR3"/>
    <dbReference type="OrthoDB" id="3426327at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18821">
        <property type="entry name" value="GH43_Pc3Gal43A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22925">
        <property type="entry name" value="GLYCOSYL HYDROLASE 43 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22925:SF39">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017694661" evidence="5">
        <location>
            <begin position="19"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW78370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="485" mass="53920" checksum="9A835735506DA883" modified="2019-01-16" version="1">MALLQLLVGLLLASTVQSKWIVPGARWRDTKGDLVNAHAGCVTIDKESGKFWLFGEYKTQGQTEGGGVSVYSSDDLATWESHGLALKPVNDSAYISPQNIIQRPKVVYAEATDQYHMWWHADNSSYGLLLQGFATSDNIAGPYTFVNATAPLGNWSQDFGLFTDYKDGRSYSLYSNGDRKDARDVYITSFNEEVTALDEVVYRFNKFDLEAPTIIQTDKSYYALMSHKTGYRPNNVVAFRADSLSGPWSQPFMVAPRNTRTFNSQSGFTLEIKGAKKTTHLYLGDQWDSNSLWESRYIWLPMEIDDNKKTLDVVWYDVYDLNVVTGEVTPITGKAYHANEAQVNGSAFKQEANFASTGVIATGIYGNASKVTFEGIEGTGKPQWVSFYYQNTDDMGFGDQPGGTPDRIGGSWQLRRISSVIVNGDVSKIETLYQRDTHKGIILSAPLQLTLNKGANNTITVGGLFNGFDYKGADLDRIIVYPSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S219</accession>
    <name>A0A3D8S219_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_05023</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S219"/>
    <dbReference type="OrthoDB" id="67965at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW80325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="178" mass="19012" checksum="9B79658411977AA2" modified="2019-01-16" version="1">MAEQDIHNSHLGVNQTTISQKLSDATKTLTDAFTSKTSGAEQDRHASHFSNGPIPKPDFSNSSGAEQDRHASHLSTGPLQDKVQALDNTASHFSLDTMQYQPISSNGSAAEQDRYASHLSTGAVSKPDFSNTSGAEQDRYGSHFSTGPIPKPDLSHSSGAEQDRYASHFSRGPIPGTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2I2</accession>
    <name>A0A3D8S2I2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_05183</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2I2"/>
    <dbReference type="OrthoDB" id="5368598at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023041">
        <property type="entry name" value="Glucose_rcpt_Git3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022596">
        <property type="entry name" value="GPR1/2/3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF37">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR GPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11710">
        <property type="entry name" value="Git3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11970">
        <property type="entry name" value="GPR_Gpa2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose receptor Git3-like N-terminal" evidence="7">
        <location>
            <begin position="43"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="G protein-coupled receptor GPR1/2/3 C-terminal" evidence="8">
        <location>
            <begin position="439"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="314"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="567"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="567"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="629"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW80485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="651" mass="73546" checksum="8D702122453796ED" modified="2019-01-16" version="1">MGLHVTHPRHIPSQSKRGLGNVTNITSSIAGTSQTVSDHEAYVLQCLALSFSVVSVASATLAFYWFVKMRRSFRHDLIMLLIQSDMFKALWFMVYPIVTFIHGPVRTNSTFCQVHGFFIALGIEASDFAILMIALHTALYIFKSRTAAAEGGLYPYRYTAYLLWVIVPTIMAALGFLNGDNAYKSNGTYCYLPARPFWYRLALSWIPRYVIFVVIVAIYVSIYYYVRYKFNHFAKEESDSSGGSNGSGASNPFKRSSLPTTPTLASHGLIPALRPASYDDAALDARRKRKQSVASPDIEAHRFIWASVVSRENNPVAPLTPPPSPPIESSLVDFESPAAGPSSPSIQTPPQAHTPYITFSLRTPPPETPSLSGQTSWTNTFSSPFSNSDDDSSHKRSIADIFFNRRQKPSSTPATTPPATRLQLLNSQGQDFAVSEMMRTREKIRRQLRFLFIYPLVYMVMWALPFASHIMQYRDSFANDPPFILSCLTTVCICSQAAVDCWLFSTREKPWRHVPGNESNHTFLRSLRFWSGWTEVKARRKSKQHGPGKTRQEMAREAMQAYRRRDEEMAERRRDSGNFEAARVKPERSWWDDRPADETPDLRLMSPVTEERSHPMEDALLTAPTTSSEKVKTIETHGEGNENPTKEDKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2Q8</accession>
    <name>A0A3D8S2Q8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_05244</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the NRP synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416786at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043041">
        <property type="term" value="P:amino acid activation for nonribosomal peptide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010106">
        <property type="term" value="P:cellular response to iron ion starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031169">
        <property type="term" value="P:ferrichrome biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05918">
        <property type="entry name" value="A_NRPS_SidN3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000015">
        <property type="entry name" value="Nonribosomal peptide synthase SidD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000033">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000024">
        <property type="entry name" value="Nonribosomal siderophore peptide synthase SidC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.30">
        <property type="entry name" value="Nonribosomal peptide synthetase, condensation domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003417">
        <property type="entry name" value="PRK04813.1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527:SF1">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45527">
        <property type="entry name" value="NONRIBOSOMAL PEPTIDE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="1593"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="2137"/>
            <end position="2213"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="3202"/>
            <end position="3279"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="3750"/>
            <end position="3826"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="4315"/>
            <end position="4391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="4300"/>
            <end position="4319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="4306"/>
            <end position="4319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW80546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="4834" mass="535461" checksum="F93257CEC27BC4CA" modified="2019-01-16" version="1">[encoded data, 4834 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S304</accession>
    <name>A0A3D8S304_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative pathway-specific regulatory protein nit-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_05179</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S304"/>
    <dbReference type="OrthoDB" id="2162761at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF81">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="55"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="758"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="817"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="861"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="763"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="824"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW80481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="880" mass="97188" checksum="AD83BE6A8643DCE2" modified="2019-01-16" version="1">MADIDADSMMRSGAGGNVVARLGAGGGGDEGQPSKKKSRSSRDAAAIKRRCVSTACIACRRRKSKCDGNTPSCAACSSVYGTECVYDPNSDHRRKGVYKEKLDSLKTRNSTLQTLVQAILNATEDEVPALVRQIRTCENLDDVADQIMREEQGIEEEEAENLELAYTTDLPTFETELSGKMGELRLENGSVRFLGGTSNLIYLPPTDEDEGNTDLEYLQQDDPLTSWTTVTKDTEVIVHLINIDFLLGKPPGTPRRTIYCSSLLVNAMLALGCHFTNSPRACSDPNDPTTKGDAFFAEAKRLIVDNDEYEKPRLVTIQALCLMSVREAGCGREAKGWVYSGMSFRMAMDMGLNLDSGGMTAHGRLNKDTMDEQEIDARRITFWGCFLFDKCWSNYLGRLPQLSTANITAPKYDVFPDEDADFWSPYTDNGVSQLHSQPSRTRTIALQISSLCEISSDLLVFFYHPQHIEKSVGKSQELKRLSELQTRLEAWRKDLPTELEPKEGQLPNVLLMHMFFNLLYIHLFRPFLKYSPSTSPLPSHVSPRKLCTHASGAISKLMRLYKRTYGLRQICNIAVYIVHSACTIHLLNLPEKTAKRDIIHGVKHLEEIAEDWLCARRTLSIISVLARKWKIDLPEEASTVLARTDVKFGFFSTADVPSPKPELVVATPPSIIRSPPQVRPQPLPVTQDSNQLRKSLYSYLPDTTSNIQDSSPITQFTTQTLNQNAPQSMQQGLGSLNATNLMQMPSIPYPSVPTYAASTLPRSDSGTTTSSSNTLTRHVSPSNMFGGVDALVESQDWWLRDQASLAMGFDNWMGGDQNGSNTSGVPGLLNNGNGNPPGPAVNENGSGVSVGTLAENGGFYMGANENGKRESGFSDDEWYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S334</accession>
    <name>A0A3D8S334_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_05376</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S334"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW80678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="97" mass="10502" checksum="E9F359054475695F" modified="2019-01-16" version="1">MGQSVTVLVPPESDVAGTLHEQNATSMNGDNPEANGDAVEDQENELATEELTARNLAKIEAQRATTIAASHAYSSFYSSNIFLYSSYKISSRNQYPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S362</accession>
    <name>A0A3D8S362_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_05441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S362"/>
    <dbReference type="OrthoDB" id="5286775at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW80743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="419" mass="47288" checksum="A548F8F83B39EFA2" modified="2019-01-16" version="1">MDQLFKLGELFAGYFSPTKRRRTIGGSVATPSREPVSTELPATDPVRRNRTTATKRHSAGPSNKQFLSGSRKRARDFDNVDCILESNHVKASVESEYAASLGSFSNNSSFSASSLLDPDDSASQILPNNADISAITDYDEEEGEPQLTAEEKIGLWREKERKLEPAKALLNDTIAQGIWTEDEKFLLQRLAMRSYEPLFPAEWQLDFPTFPVGLFTLDFSKTFINFNCTSSHKAVRAFQALIDLAGRVRDKKSVRLPVERVMELEIKRYARWTEEDGGYINLRFVPNTVIVTKKPAQTFQESSHDLISQMTFLAEKYRAMLALPTPNIGKLGEIELYSKQPPIIYGITIVSSKVFLWTMNSAKIGAKPKFIQHFEFAEEGMDVWNAIAVAIFLVMARNYIISIKDELEPDFDDSDDPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3G2</accession>
    <name>A0A3D8S3G2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_05545</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3G2"/>
    <dbReference type="OrthoDB" id="10459445at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW80847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="199" mass="23082" checksum="F1B2F4B473213DD2" modified="2019-01-16" version="1">MSAQMSFAYQTISAVDFPGMAQCNDNYDVDHAYIDNLKFIVGMVERRARKSQKNQNDKNNDKETPNIASNATQEGVVRKQQDEVKKFRDQIIDKPKVSTKQEEEGLRRSFREAVARKAALSAKTERQREVEAQREAEVQREMERRVETEIETERRDQELKMAMTGRGPFVEVLGPCPRPQSEEYDAWMDRATAIFIPYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3N5</accession>
    <name>A0A3D8S3N5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_05382</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3N5"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="130"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW80684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="233" mass="25114" checksum="38C9200DD6C973FD" modified="2019-01-16" version="1">MGGTLFDADDADADAAAYDARHSPYGCAVPTCRFPVPEPNPGFKRKKLVCAATYIRSAPFPPSNPIAGADSTVPPDSHPALTRRSQVAPGRQLLGNYWSCWDDTRASVGWSFSTVRSHRRRRPIAAMPCSATPNSTAAPSSVNGPRARGRALQQCPQYWFFERATANSLAHSSRTDLIGSRLGGRKQQQPPAENNHCGAPSTGLDWRHWTGQPLAAATATNELIVNSSTELKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SA53</accession>
    <name>A0A3D8SA53_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAS1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_04475</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW82984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SA53"/>
    <dbReference type="OrthoDB" id="286301at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017747911" description="FAS1 domain-containing protein" evidence="1">
        <location>
            <begin position="28"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="27"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="2">
        <location>
            <begin position="208"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW82984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="322" mass="34337" checksum="D81C38A38BD3F160" modified="2019-01-16" version="1">MTLRTIPLSTAVMKLILISYLPVVVRAQSFLEAIGAYPQLSNFTSLLTNYPVLASSLLSASAISPQTVMVPDNTAFLKYENSTGISISAIPTDDLVPVVDYHILSGLYLSQNFATPQGITVPTYLVGPQYNNRTAGAALSSVGATNGSHDGQVVFIAPKTNGSTLLGRQLSSAGVVVQSGRKQQVNLTAIDGVWDGGSFHIVDGFLTLPKICTETIRAWGLLSMDRALDRTGLSSVVDHLNNVTCLGPSDQAFLQAGSPDVKANASALTNDILFHTIQQPLYSNFLQDGQTFASLSNATIRVTLKDGDIFFNDARVMHANVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SA95</accession>
    <name>A0A3D8SA95_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SA95"/>
    <dbReference type="OrthoDB" id="4140442at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW83236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="320" mass="35584" checksum="CDE592AE81205510" modified="2019-01-16" version="1">MSLFSRRCLFKHRSSFNTTETLNALFALKTTSRPRLFSITARQSAASATVKHKAPKVKQASISKLRTSSIKNASQASAIARPAYQSYAAQLAQKSSPVLLYQAPSHTLYKISCYGGSVFCFAYAAWNFNAHYLNADPGLASWVPIAFGGICFLMAGVGGWLVLGPARVVHKITAVPQKAVSANGQPSLMIEVELRKMLPIPFLSARKLLVKPDEVKLPNSFSPIVSRKSASELAAERKAAEQKLKEFREYEDTHVMTRPFRHMKQGAGEFFQALRQAWTREGFWSLGVKEQRYKLDVSRGWVLDGGRALERVLTVDKRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAJ1</accession>
    <name>A0A3D8SAJ1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04652</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAJ1"/>
    <dbReference type="OrthoDB" id="4159838at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="165"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="828"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW83161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="862" mass="94892" checksum="D5083E662485A66D" modified="2019-01-16" version="1">MAIKAVHGTSPTTYSFTPVRRRPSSFTSGYLQEGIGQEWTAVRCHRLLRPLTSRIAILDKDVALFPSAAAAAECPKIRHKSKSAGSSQDRHKSEFEDSQGSDADWGQQQPRKRVKRTYSSRASQRKASSHRGLGKSKASSASSGSIDYAAPGSITVSTPVLTRSSEPHVATADGHIGQDFTYSRPKRARPRCAAQDNDAYRQLLHLRRVLPAARYSIYEGIYNGFEALLRATNTVTNRLRPRESRSLFSTCLKTIPRYIAKEREMHSTENSGNKSTLEMQDISLEIYDELESLGSSGNGWKHLRTVLRAHGIHIITSAIHRGILDLPLCSALVTLCATTHDLNAGQSILSSVLTLESIPAPKTVFCRISSAGISPSMCLLWDFVNRTSQRAYHLRQITKMLVNGLIPVTWLATKDFGQIWTMAIQTLSTESDNADAATFLQTALSTLSSTVLHQTNAIEPLTQSDKSLALAVEQTYSSLLTTLTSIAILSQERSIAASSDLLAADDQVCGAISRMLEYCLAENSSTTAERNCLWIASLLLCHCTDMFTSSSTRNRSDDLLMKHNLLSTEVDVDCSVLAELVYSISACCARAGFSRQLDYLQKIHSILEKYMSSASSKQHSIIVQMIMDSAVRLCDEVPNQDHVDYAAHASTRFEGFNRVPRPDLHCGTSNYVVGTEFRWEEGISEWVTATPALNVQKSKVVVEYHSTDESETETPYRSSIMRRRNALRQTCIDAPSSEPDKVAESEQDSSLMSEDVFAEASFTSMSSQDSEPAQQDPRANSLCIRSSTGLGQRGAKSLDNVEASDDELSFNLSASHVKGTITRCKNVSRRSFSRAPTRSKSRKISSDLTAPAPDDSEDELCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAM9</accession>
    <name>A0A3D8SAM9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor CWC22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Pre-mRNA-splicing factor cwc22</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_04876</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAM9"/>
    <dbReference type="OrthoDB" id="3938623at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000004">
        <property type="entry name" value="pre-mRNA-splicing factor CWC22 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF3">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="MI" evidence="10">
        <location>
            <begin position="348"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="305"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="544"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="559"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="615"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="689"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="725"/>
            <end position="734"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00069506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW83385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="792" mass="90327" checksum="8FDED5FF77F83BD7" modified="2019-01-16" version="1">MADQRVAVRTEEEKQALAKAEYEKLLNMRSGGTYIPPARLRALQSQITDKSSKEYQRMAWEALKKSINGLINKVNVSNIKFIVPELFGENLVRGRGLFCRSIMKAQAASLPFTPIYAAMAAIVNTKLPQVGELLLKRLIIQFRKAFKRNDKAVCLSATTFIAHLCNQQVANEMVAAQILLLLLHKPTDDSVEIAVGLTREVGQHLEEMSRPIALAVFDQFRSILHEADIDKRVQYMIEVLFQVRKDQYKDNPAIKEELDLVEEEDQITHRTALDDEIDVQDGLNIFKFDPDWEENEEKYRRLKAEILGEGSDDEEDDEDDSDDSEDDEEKKEEKSLEIKDQSNTDLVNLRRTIYLTIMSSIDPEECCHKLMKVQLPAGQEPELPSMIIECCSQERTYSKFYGLIGERFAKINRLWTDLFEQSFAKYYDTIHRYETNRLRNIARFFGHLISSDAIGWHALSVVHLNEEETTSSSRIFIKILFQDLSEAMGMPKLQARLKDETLRSSFEGLFPHDNPRNTRFSINYFTSIGMGAVTEEMREYLQNLPKPALPPPPPGGDSGSDSGSSVSSYSSYTGSSYSRSRSRTPSRTRAIDRRSASITPPRNGKGKEVRRGRSLTRSLSRSVTPVRRGARRDSRSITPPQRYSRRDSRSITPPRRNARDYSESVSPPPRRGRQDSYSRSPPPKRGRSYSGSLSPAPQRSARRNTSSVSAAPRKRQASVSRSPLPRRDNRRESYSRSPSPPRGRRDSYSRSPSPPPRRGRRDSRSISPAVKRRREYSNSRSPPPPKRGRRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAR9</accession>
    <name>A0A3D8SAR9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_04960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAR9"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="5">
        <location>
            <begin position="24"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="4">
        <location>
            <begin position="317"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW83469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="655" mass="74497" checksum="6B716CCE8976E942" modified="2019-01-16" version="1">MLGRLEMEPKDCIRAYVELSKTIFEKKGSPLQWNGNIKGRFDSTVLEHALKKIIVDQGYGEAEMFNNGEDRGCKVFVCAVAKETKGITRLKSYINPSEAPSEATICQAALATSAATSFFDEVRIGSRTYVDGALGVNNPVDEVEKECSNIWCSETGDLKPLVKCFVSLGTGNPGKKPLENGAWEFLSKSLKDIVTDTEKTAENFKARWRGHFDRKRYFRFSVEQGLQDIGLHEYLREGSIKAATEEYLEEQSQKFSLRDCVSNLKLKETITPYNIERLIVAYKDDCDRNRVLGQEVKKYYEVPKRLVERFVGRQSLLSQIEKHFSVSSEPAPNVLILQALGGQGKSQLALKYCQTMRKTYRGIFWIYAGSEATVSQAFEIIADTLNHDKSVLKDPQQKVQFVKDTLHKWDERWLLVFDNYDHPKDFPNVKEFFPEGRGDILFTSRTQGLKRLGTPISIPEMTKDEGLELLLYDCSSRNEAQTRQDGSEVIIRLGGLALAIDQAAAYISYKQVPIWQFLAEFETKREDILKFTDHDFWEYGAIPFPGVKARDKERDKAINAFTTWELSFEQLISANQQTSEHLDHFLTLSAFLNPSNIGEVLSETYFDAKGDSTNWLQIFTRSEHTDSSNEDTSSSIVVWKPLKYHYGNPKASGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SBN1</accession>
    <name>A0A3D8SBN1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SBN1"/>
    <dbReference type="OrthoDB" id="6077919at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW83168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="409" mass="42322" checksum="1CECC424DD74C757" modified="2019-01-16" version="1">MTTVENLSHASLPSPTVHVPKVEDNNSVYDSDDGQLRDSPLLKPMRPNLEPSPSPPPAVSQVSPDSSPGRKASNRSKVRPSQSDAVLVAFMDGGKHPEIAIGAGMEPLPSDDDSPEGSVKAIEVIFRRSPDLTALAAGALAHVDRHAQDKSVAPAPAAAAGGGGGEGGGNKTSTIPSGDSRLGASPHLDGDAMDGVVKPRIPPMSTGSSYAPTMRRAPTSSDTPSKVETSPSNVAGELPPIQALSPQSGPHGIGAVPITLPGLRDQLGDLNQLGEAISSTEPSFSQSPQVRPPPRFSTSLTGQATSPTPLSPTDFRRDLPSPSHNVSSYYAPSNYRKPSQSDGGPGYVSNADYSSSNTETPSTDQSASTPALGIDRMSIDGITNPQIGGFQCTYVGCTAQPFQTQVRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SLU1</accession>
    <name>A0A3D8SLU1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02977</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SLU1"/>
    <dbReference type="OrthoDB" id="6250593at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW87283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="118" mass="13106" checksum="5A1BF6C21B895802" modified="2019-01-16" version="1">MPDVAQINRSLNTLRTELEFLRDSNVLSPAQFQSISAQLPQQGGVPSQYVDPRYNPQTQFNPMQFAQQAQDPSHPAHPDNPKHHEWAKNLAMKFGNAAMFGAGATFGGDMVNDALKHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SN87</accession>
    <name>A0A3D8SN87_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_03493</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SN87"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12169">
        <property type="entry name" value="PGDH_like_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050857">
        <property type="entry name" value="D-2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="5">
        <location>
            <begin position="49"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="6">
        <location>
            <begin position="130"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW87799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="364" mass="40243" checksum="21614F04F8FD893F" modified="2019-01-16" version="1">MTAQAPIKVAVLDDYQGLAKAHFAKLPPKFETTYFPETLLPYNRTSTPEHVKAQLVERLKPFTIISTMRERTPFPRELLEKLPNLKLLHSTAKRNLSLDLEAAKDLGIAVHGATELKKRNGPDSTTQHCVALILGIARNLAHDDLAVKTGSWQTTATVGLAGKIYGSVGLGRLGLSVTRILVLGFGMKVICWSSSLTQEAADQKAREAGLPVEDEDGEKTFKVVSKDELFKTADVVSLHYVLSDRSRGLVSAKDLALMKPSAFFINTSRGPLVVEADLLRVLKEGKIRGAAIDVFDLEPLPADSEWRTLEWGKNGSSQVLLSPHMGYVEEETLSKWYELTVQNIERWGRGEPLIESMTSVHVYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SNG4</accession>
    <name>A0A3D8SNG4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_03559</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SNG4"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW87865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="112" mass="11780" checksum="4E5E29E843D7C962" modified="2019-01-16" version="1">MHLASGIEPLGTARAPIVTGQVLSNSQEKTTAPAQDRFFIARIAGPDLRSMARERRVAVDAGVELVAAFVLDGDDVERGMVMCALGLRGEGEAMHDGFGHCGGWGLVGALLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SP08</accession>
    <name>A0A3D8SP08_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">2-methylcitrate dehydratase PrpD</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_03605</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SP08"/>
    <dbReference type="OrthoDB" id="10267976at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF8">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="2">
        <location>
            <begin position="15"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD C-terminal" evidence="3">
        <location>
            <begin position="288"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW87911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="52292" checksum="C380A5C4A947D587" modified="2019-01-16" version="1">MSSFKVTDADGQTGQLCNWIDQVTLDDIPEELQTRAKYLILDGIACALVGAHLPWSEKAVRAISELEPNGTSSVFGWAMNVTPLSAALLNSSFIQGFELDDWHSEAPLHSNSIILPALFAAGQHLGTSNTKTSGKSFILAYLIGLEVGPRVGQALYGADMLSRGWHSGAVFGPAASAAAVSKLMNLPAGQIEDALGSACTQACGLMSAQFESDVKRMQHGFAARNGLLAAMLARSGYVGIKRVFEQEYGGFLTMFGQGSQKEPPYRVDEISKGLGTEWKTNGVRVKPYASMAGTHPTVDCVRKLQEGHPEKMKQLDRITSIVLELREATYHHGGWEAKRHLRAIGAQMSNTYICATQLVDGEVLPAQFRNQKLERDEVWDLVDKSTCRNMGKSNPMRQKVTIAFDDGTELVAEVEAAKGVDPPLTNEEIVDKWRKITVEVIDRERMEKIEKTCLGLESLEDITVLEELLRGITKNPIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXB1</accession>
    <name>A0A3D8SXB1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02132</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW90967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SXB1"/>
    <dbReference type="OrthoDB" id="4207123at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42095">
        <property type="entry name" value="YALI0C12166P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42095:SF1">
        <property type="entry name" value="YALI0C12166P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW90967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="160" mass="17237" checksum="D47554B657D68348" modified="2019-01-16" version="1">MPTQRPFFANFLASFRAHSAIQQQSQKGPSASTQSTAHSNTATSSNNAPSNPRTITTSTKTGGGATATALSNLHSPRALSTSTSPLSTSPSPEQNQSRYMERRTVRRGSDSSSEGFRDVLGAEKWYIGGRTAAGEEKFFKLGVVRRQRSGDRLSLDRLSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXB2</accession>
    <name>A0A3D8SXB2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative amino acid aldolase or racemase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_02075</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DSD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW90910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SXB2"/>
    <dbReference type="OrthoDB" id="20198at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008721">
        <property type="term" value="F:D-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036088">
        <property type="term" value="P:D-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06819">
        <property type="entry name" value="PLPDE_III_LS_D-TA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.37.20">
        <property type="entry name" value="D-serine dehydratase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051466">
        <property type="entry name" value="D-amino_acid_metab_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026956">
        <property type="entry name" value="D-ser_dehydrat-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042208">
        <property type="entry name" value="D-ser_dehydrat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004:SF2">
        <property type="entry name" value="D-SERINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28004">
        <property type="entry name" value="ZGC:162816-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14031">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01119">
        <property type="entry name" value="D-ser_dehydrat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-serine dehydratase-like" evidence="3">
        <location>
            <begin position="238"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW90910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="343" mass="37186" checksum="88F3854FBE1F200D" modified="2019-01-16" version="1">MEENIRKLMGLLKPMKVNIRPHLKTTKSPILAQKLVDAGATGGCVAKLSEAEVMAEAGFDDLLITCEIVGPVKVRRLVELFRNHRKIQIVVDSEFGAVAVNKALSSSGIEQPIQVLIDLDVGLHRTGVAPESALALAQHISRLSYLKLIGIQGYEGHLQHVHGRETREAQCRASMAILTSTASILRKNGFDIQVVTTGGTGTAEFCATTPGITEVQPGSFIFMDSDYYNAVGGYFSQSLTVLSTVISKSGSEHRVTIDAGLKSLPTDSGFSEPKNMPGVTYTPMGDEHGWLSWDDGPDVPLGARVEMIPSHIDPTVNLHDCYYAHRKGVIEEIWPVATRGKVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SY25</accession>
    <name>A0A3D8SY25_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcriptional coactivator p15 (PC4) C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_02339</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transcriptional coactivator PC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SY25"/>
    <dbReference type="OrthoDB" id="2505440at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060261">
        <property type="term" value="P:positive regulation of transcription initiation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.31.10">
        <property type="entry name" value="Transcriptional Coactivator Pc4, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003173">
        <property type="entry name" value="PC4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009044">
        <property type="entry name" value="ssDNA-bd_transcriptional_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045125">
        <property type="entry name" value="Sub1/Tcp4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13215">
        <property type="entry name" value="RNA POLYMERASE II TRANSCRIPTIONAL COACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02229">
        <property type="entry name" value="PC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54447">
        <property type="entry name" value="ssDNA-binding transcriptional regulator domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcriptional coactivator p15 (PC4) C-terminal" evidence="8">
        <location>
            <begin position="62"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="120"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW91174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="164" mass="18596" checksum="0719A987E5F2282B" modified="2019-01-16" version="1">MGRPRKRSIDEVDGYQSDGGFVSNSDGKTPQNKKPKKVTDKLDEPAQDDEGNPYWQLSSGRNQRRVGVQEFKNTQMVNIREFYEKDNRFLPGKKGISLNIDQYKALLQAIPHINKALRGKGVDISEPDLAMKDEDGSEADTKPLKRVRTKQEKSNIEATSDEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYA9</accession>
    <name>A0A3D8SYA9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Oligosaccharyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_02326</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OST3/OST6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYA9"/>
    <dbReference type="OrthoDB" id="67566at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000302">
        <property type="entry name" value="Oligosaccharyl transferase subunit (Gamma), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021149">
        <property type="entry name" value="OligosaccharylTrfase_OST3/OST6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692:SF0">
        <property type="entry name" value="GH11935P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04756">
        <property type="entry name" value="OST3_OST6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017646965" evidence="10">
        <location>
            <begin position="19"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW91161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="329" mass="36478" checksum="99CCF6BD58656138" modified="2019-01-16" version="1">MHFFKALLLALLPAASLGAKKVATDKFQDFHLKALSSAPLKLADKSYDKLTASPRDYSVAVLLTALENRFGCQLCREFQPEWDLLAKSWTKGDKKGDSRLVYGTLDFMDGKGTFQSLGLQTAPVLLLFQPTTGPHAVADSGPLRYDFTNGPQSAEQVHAWIARHLHDRPHPVLRRPINWVRGFAITTTILGTITFITVAWPYLLPVIQNRNVWAAISLIAILLFTSGHMFNHIRKVPYVAGDGRGGISYFAGGFSNQYGLETQIVAAMYGLLSFATISLALKVPRIADPRTQQVAVLIWGGVIFVMYSFLLSVFRIKNGGYPFFLPPFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYF3</accession>
    <name>A0A3D8SYF3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BP5796_02366</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYF3"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="206"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="413"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="44"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00037449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDW91201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="592" mass="64889" checksum="0928ACE39A90BFF2" modified="2019-01-16" version="1">MAKRTLQDAELANGASTVSSKKSKKERKQVQEDAPEKTSTPKANDGETKEERKERKRLKKLKQLEESAAEDTPTAVQSTETEDSKDEKALKKAEKAKRKALKKAEKEAQSQTSEKPANSPAAKTVSSEHPTNSNGSYTESAELSALPQAEIDKFLADHFITVTDPLSATNKLRPITKFSHLPISDPAQLTPFKTFTAPTPIQAAAWPFLLAGRDVIGVAETGSGKTMAFAVPCVRYISSLPGGQKNKGPKAVIVSPTRELAVQSHEQIMKLATASKLQAVCVYGGVPKDEQRRALKTADIVVATPGRLNDLINEGCADLSRVNYVVLDEADRMLDKGFEEEIRKIINAALPLGKRQTLMFTATWPENVRSLAATFMTTPVKIAIGDNPTGDLRANTRIVQKVEVVDPREKEYRLLQLLKQHQSGTQKDDRVLVFCLYKKEATRVEGFLHSKGFRVAGIHGDLSQEQRTRSLEAFKQGGTPVLVATDVAARGLDIPNVRLVINVTFPLTTEDYVHRIGRTGRAGKEGLAITLFTEHDKAQSGSLINVLKAANQPVPDELLKFGTTVKRKEHGAYGAFFKDVDSTKTASKIRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYG2</accession>
    <name>A0A3D8SYG2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">U4/U6 snRNA-associated-splicing factor PRP24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_02464</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a recycling factor of the spliceosome, a machinery that forms on each precursor-messenger RNA (pre-mRNA) and catalyzes the removal of introns. Chaperones the re-annealing of U4 and U6 snRNAs (small nuclear RNAs) released from previous rounds of splicing, an initial step in reforming the U4/U6-U5 tri-snRNP (small nuclear ribonucleoprotein) that can reassemble into another spliceosome complex; this step involves binding U6 and facilitating the unwinding of the U6 internal stem loop, followed by base-pairing of U6 to U4.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYG2"/>
    <dbReference type="OrthoDB" id="360390at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12297">
        <property type="entry name" value="RRM2_Prp24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12299">
        <property type="entry name" value="RRM4_Prp24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000523">
        <property type="entry name" value="Pre-mRNA splicing factor (Prp24), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000588">
        <property type="entry name" value="Pre-mRNA splicing factor (Prp24), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000365">
        <property type="entry name" value="U4/U6 snRNA-associated-splicing factor PRP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034398">
        <property type="entry name" value="Prp24_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031766">
        <property type="entry name" value="RRM_occluded"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16842">
        <property type="entry name" value="RRM_occluded"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="583"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="661"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="752"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="882"/>
            <end position="955"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="532"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="831"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="976"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="562"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="858"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="991"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1016"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1028"/>
            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00093374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00093627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW91299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1046" mass="116604" checksum="CE54A09858CF6FF8" modified="2019-01-16" version="1">MADPVGEDGWMSLVDEASRSAGDLEQRVGVVELYKRALRAEPWSTKLWLAYCEWFWSLYTDCQTSDAGWPEEEQMVGQEIFSLELALEAWQEAAQATQYRLSDSHEVWNRWISIELEELSKAPTRPRINRLRKIFEDRLQIPHAAWDETSQTFSTFISKYDEAAWEATMVKITQLAKKAKEIYGQCEAYELKIQKAVESGDIETTKLATKEYLDWEVQQVFKAMHKKPGKKGPPSTPPILCIALYERALSSLGLGSDPATWEDYISFLSVVKADIAGPNFPTIRAVLDRATSHCPWHGPLWARFILSAELDGLSFSDIEHIKHTATSTGVLERDGIDAVLDVYAAWCGYLRRRTVAQGASDEDMDVAEVGLQAALESVQESGVRLYGKKDYKGDPNFRIERILINFLTAKGAIEDARNVWRKLTAVRGDSYDFWQQYYFWEMTVRTSPRTSSSSLATGVLMQAANRKTLDWPERMLEVYIRHCSNYEDAPTFSSALDICHRMSKGVAKRRQREAAEAAATYAQQQPQIVVENSAAVDESLGSSKRKRESTSDEIDGTSSKKVKSEEEEKAFQEQHLKRDRENTTVLVTNLPEKVAATKVRQYFKEYGHINSLTIEPEGDGDNVSSTALIEFKSTEDVQSALLRDGKYFAENQIHVEPGTGLTLYVTNYPPTADEAYFRDLFKSCGEIFSIRWPSLKYNNQRRFCYISFRTKEGAAAATQFDGQMLQSRYKLVAKYSNPAAKKAREGATAEGREVHVASLDLSATEEELKEIFQKYGKVQGVRILRNMAGRSKGAAFIDFEKPEEAQAACELNGTKFKSQIMKVDVSKSVNFKPTTTTGKASSASPAPDADGDSVMSPAPTSGEQHPNTHAFETPSSSEISARTIALINVPDTINDARIRALVEPYGTITKLSLRLDHQGAIIEFSDVAEAGKAALGLEGYEIAPGRKLRTGGLKDLFHERDEKRTDRIQIGQNKKPAPMFVQPSAPVRRPGAGGRGGLGQKRGLGYAAPRNPATAEGSNSTNGTIENGKPKSNEDFKKMFLSGGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYU0</accession>
    <name>A0A3D8SYU0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02615</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5382102at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42105">
        <property type="entry name" value="DIM2-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42105:SF1">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="488"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="730"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="909"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1095"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1155"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1375"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1474"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1564"/>
            <end position="1611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1626"/>
            <end position="1887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="446"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="504"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="597"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="612"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="748"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="812"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="919"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="951"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1475"/>
            <end position="1484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1485"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1585"/>
            <end position="1594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1658"/>
            <end position="1671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1717"/>
            <end position="1730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1741"/>
            <end position="1771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1791"/>
            <end position="1801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1875"/>
            <end position="1887"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1887" mass="207116" checksum="1AF84B79A1031DE4" modified="2019-01-16" version="1">MGVESRRAAPPLPAPTETDSTIGHNTSPTELDSKVTEKTTYSLPEDGTPVTISTRRKKHDKDGKGGLTSNKSQTSLLIEYFEGGKGSHAESRRPSVRVKVTPSSKSRSRSANDHIQITETKGARKPSYTKRIQLSPNAKAEGEGDDKSLSSYASATEESNLSQRPIEVEIMPRRHGSPLIPTGESSRYVPVNASDISSMPADSFLDGKSGSPERTRSRSLTRGEVLAAGAATGLVAGEIADKLRTPSRRRSRSLSRERIVVQKAVEKVRGDKSEHRRKRRERSRSVSNSELAEGIKSPRRRSSRSHHEESMITGGESSLLSNQSRKSGDAYSFRSGTSKSSINNPKLLETVEDAIRRLILPELTALKREQSKHTSREKDRRGSITSASGISRDSRDESVISGKRSTTDLSGRPSVAVNDEEVITSTPRRRRERKSDRAVLDGSPRSFERGESEDTVVQDDKVHKKRTSDKHRGLEAAAIGAGIGALTAAALKSDSKDPMDEKKERRRRRTKSRSRSDIESFEEHEKQEIVPPMPLMSDINASEITRSSILSAETDRPLSASDEHRVTPVWEVPRGIASPSQRTPTRTPVALQQGLGTQHSNFSRGNLSLHSQDSEHHLHSQEYELDEHGRKVPMHGSSLRQEEQYEEDEDDISHSNALGAGLMGAAAGGGLAALRNRPYDEEEIEENDHHDPELEQSRGHYEYYQNHQEVPPPLKYVPYGYERRGLSPIQSVSGYTEDDYDHQKQRNSRLTQSTGSYSSLNKSAHHKDSARSMRSMDSTGNVHHNNHDFPNVRTGGLTDSELTQQTDGEYWEEQHRENDRARDLDGTDSYRSYDGPRDQKHMSNYTNDSMVSGELDQSTAGRNIRDVGANPDYVHTPIAVESAVASLVNPSELTGSGFSANGQYDRRGSYASFEDGSEEQFTSRGNSPTKQAIRKHPSYNPDDNGMLSQFESRENSPTKEHAEYGLDEHGRKVPIPEYEKSHTAEKAGLAGMAAGAAAVLLGHRKHKSSADEIQYEDRLETTGAPLQKSFKDRASEGPIPSPKHSIDALSEAASHQRYQMGASGIPDEHDPMPEIGYGDGESEVTTNPSIIQGPIGGSQQDREHWSGHTTPPRTRMPLSGSPAQHSEGGMKAAEAALLGAAAGAGTAAAISSHNKELGHEHELEEQDDEWQRTSAERKRDTLVTNPWEGTSPVAALPDGLDHEMLAQGGYQGINHDFGSKMGYHQAGSPVNMTKDEGYISSAPNARSPGALTPEPRAKGVGFLDQELGGGQETTGDPFYTPKHNRHLSGMSHGMGSPLYDSATGNGIDRIQSRDIVALMDHLTVRDAQRSARDTEILVTLVRAAAEMRNSFEDMKRLLADTEDVIITEVQQNTDRSIQKAINGPRPQPPSVPRSLRQGSQDEMHEDIPTKRRNVFRRALKGLSMKSSNDLGKIEEMLVQLLGEVEGLKVAQGLKPHSSAGATYDDLHLQQEGNYENDRGYEPEGHSTTASHASQSGPLSIPKSRGTSAARQQDARKFSDYRISTVPEGDEEDLDARREEIDPHEQAVLNNQFENNEQLLTPTREDFRSGSAPLGTPPQHYVEPASLSNENTPRTGTDKSKKHKSSSSSGWIPKVSRWSETTASTVLRGFRSSGRNSGRKENDQYAEPPSRSGSDLGNYEDHHNPYGDDKLHSGFSEDQLRPFDDDEPDSLLPPEDPKYKAHRNSLNLQHPQPRPGQHYQTNLESQAQNYANAPLSPKSVDWGSSTSINRLPAPQTNRYSNTTTSAGGNLSPISDGGYSNGSARGPARPPKEPIVPEIPPKLRPNKLQKPSPLSNEHLAPETAYENGSPAAKFSTGVPARKPTGPRSMGSASKSGELNRDDGTVIRRNKNRDTFGTIASNHSGESETF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZA8</accession>
    <name>A0A3D8SZA8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA kinase Pnk1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02666</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZA8"/>
    <dbReference type="OrthoDB" id="19045at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046404">
        <property type="term" value="F:ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046403">
        <property type="term" value="F:polynucleotide 3'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01625">
        <property type="entry name" value="HAD_PNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000078">
        <property type="entry name" value="Bifunctional polynucleotide phosphatase/kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000737">
        <property type="entry name" value="Bifunctional polynucleotide phosphatase/kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006549">
        <property type="entry name" value="HAD-SF_hydro_IIIA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013954">
        <property type="entry name" value="PNK3P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006551">
        <property type="entry name" value="Polynucleotide_phosphatase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01664">
        <property type="entry name" value="DNA-3'-Pase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01662">
        <property type="entry name" value="HAD-SF-IIIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE/KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12083:SF9">
        <property type="entry name" value="BIFUNCTIONAL POLYNUCLEOTIDE PHOSPHATASE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13671">
        <property type="entry name" value="AAA_33"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08645">
        <property type="entry name" value="PNK3P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="520" mass="58162" checksum="7CFFF0A188077779" modified="2019-01-16" version="1">MVSAGADKKRKSTLDHPVSPPPLRRKIQSSTTKTSVASFFTPTSQKPPEKIIWQERAPNDDTPATLLVGKFSPSNVDDHPASDTPNITRRKIAAFDFDSTLILTSSGKTFASSANDWKWWHASVPGVLQKLYKEEGYRVVVLSNQGGLSMKGDTKGPKVGKQAKIDTFKAKTSAVFNQLDIPINIYAATGKDMYRKPRIGMWEELLDDYDVDTTKDLDLENSIFVGDAAGRHASNGKAKDFSCSDRNFAENVGIKFYTPEEYFLHEEPRPFIRTFDPSTYTESSPTTTSQKSFSKRNEQDIVLFCGSPGAGKSTFYWRVLEPLGYVRVNQDTLKTRDKCVKVAGEQLASGKSVVIDNTNPNVEVRGIWVELAKKYSVPIRCISFTTPMQMCQHNDTVRALNQIMNPEKRAILPGMAFNSFTSRYQKPAPAEGFQDITEIDFKVPADPRGRLLMQSLSTSQRSSKEMRSKSKYGYNIGIDESLERWCHAMCPKPGCMMFIQSRHTDGLVILACQSFSSPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZN1</accession>
    <name>A0A3D8SZN1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_01150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZN1"/>
    <dbReference type="OrthoDB" id="5429770at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF1">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW91756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="393" mass="44780" checksum="008B0B0492CC74DE" modified="2019-01-16" version="1">MHDHLSVTIGAVSLAYYFHQTSSSEVLAEARREYIRALQLTNAALRSSELALKDTTLLATLLLDLFEKFTSPILRDSWKTHVHGALALVKLRGTKQYSDPIGLRMVMRLSINILISFVACNSALPRDFIAVRTFTADFLKTLDPKWKLTDLMVDYAAFRARLIAGQLSELETISIATKLDARYLNLMNTMPPSWRYETVNLSSTSSGVFGDHFHVYPSQHVTQTWNVIRTIRIFLNDTIRETCLSFDDSLLPQDYTQVSNAATECIENLALDICASAPQYLVDLDLIRARLKAVKCIKYPETSQNSISRPQYETSVAYLKCYTLLFPLYVAAQYTLATSTRDWILKQLHHMSSKYCFKNAHRVAEILEREDEDAEVRNPWRVYIMLGSYAFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZS1</accession>
    <name>A0A3D8SZS1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_02423</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZS1"/>
    <dbReference type="OrthoDB" id="5355510at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="3">
        <location>
            <begin position="301"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="1">
        <location>
            <begin position="301"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="365"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW91258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="466" mass="49137" checksum="DB52342069124956" modified="2019-01-16" version="1">MLGLDLKSPWSDANSASPASLHAPDKVVTKMTNSFKSSQPNPGFARTTQPALARSPFHRENSATPPVSPYSSMGTGSTNGNARCSVTIGPGLKATAQPGYGSSAYDSPSATGYTNYTVPTTPTPAREWSSDTGSYARALGSPSTSEIPVIHPFPPYNPLASGPMIHDGVPVDKVRPGPVFPTAGQVAAGFCYGIHRGNGKFTRLIPADELPSDSGIPPYCPAEGMMVLPKPQGPAPASYHPNEVPLIPRTLVMNLPIFDPNVPGTADRAAIPASQFQAAIDMIVANSAITGRAAESTHTGQKEKIYCDKWVHEGTCAFTQRGCRYKHEMPFDKATQLSLGLNGLPNWFKRARDLKIHSGADLSARALPSSAAPPQSTIPARRPGIQLVSPARLGNGGDWRARAPGGSDTGNGHSHGRSARNNYGPVARPARRDEVTSPARGNSNPYAMLSAMNDEEDNDSEAGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0F4</accession>
    <name>A0A3D8T0F4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">Adenylyl cyclase-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_01446</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">The N-terminal domain binds to adenylyl cyclase, thereby enabling adenylyl cyclase to be activated by upstream regulatory signals, such as Ras. The C-terminal domain is required for normal cellular morphology and growth control.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the CAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0F4"/>
    <dbReference type="OrthoDB" id="77251at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008179">
        <property type="term" value="F:adenylate cyclase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019933">
        <property type="term" value="P:cAMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.330:FF:000001">
        <property type="entry name" value="Adenylyl cyclase-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.70:FF:000008">
        <property type="entry name" value="Adenylyl cyclase-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.330">
        <property type="entry name" value="Adenylate cyclase-associated CAP, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001837">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013912">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013992">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036223">
        <property type="entry name" value="CAP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018106">
        <property type="entry name" value="CAP_CS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053950">
        <property type="entry name" value="CAP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036222">
        <property type="entry name" value="CAP_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652:SF0">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08603">
        <property type="entry name" value="CAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21938">
        <property type="entry name" value="CAP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01213">
        <property type="entry name" value="CAP_N-CM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69340">
        <property type="entry name" value="C-terminal domain of adenylylcyclase associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101278">
        <property type="entry name" value="N-terminal domain of adenylylcyclase associated protein, CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01088">
        <property type="entry name" value="CAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="6">
        <location>
            <begin position="377"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="38"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="260"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="323"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="59"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="272"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="289"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00054756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00072052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW92052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="537" mass="57673" checksum="02251CF2F1A3A13D" modified="2019-01-16" version="1">MATMDDKVVPTIQRTELTALINRLEAATSRLEDIASSAIDSPQANGAPASTALSATAPAPTPSTPAPPAAPKAAPIELPEQVEEFDAFISTSVKKYMDLSKGLGGAIAEQASSVLKAFEGQRRFLLIATQAKKPDMGSPAFMQLLKPLQDSITAVNDIRDANRGKPDFNQLSAVSESISVVAWVTVDPKPHKHVEESLGSAQYYGNRVLKEFKEKDPKQIEWIQTYYQIFKDLTEYVKQTYPSGIIWNPKGVSADEALKSVGGSQAPTPSAGGPPPPPPPPPGPPPKFDIPDIPEHGKPKESGIGAVFNDLNKGEDVTKGLRKVDKSQMTHKNPSLRAGSTVPTRSDSASSVSSVSRGKSPAPGKKPKPESMRTKKPPVKRLDGNKWLIENFENEPEPIEIEAEISHSILISRCSKTTIMVKGKANAISVDNSPRLSIVVESLVSSVDVIKCNNFALQVLGTLPTILMDQVDGAQVYLGKDSMDTEVFSSKSSGINLNIIDAASEEGDYKEVPLPEQLRTYITKDGKVASEIVEHAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0F6</accession>
    <name>A0A3D8T0F6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_01449</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0F6"/>
    <dbReference type="OrthoDB" id="67027at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004525">
        <property type="term" value="F:ribonuclease III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19873">
        <property type="entry name" value="DSRM_MRPL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000043">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1520.10">
        <property type="entry name" value="Ribonuclease III domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044443">
        <property type="entry name" value="Ribosomal_mL44_DSRM_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044444">
        <property type="entry name" value="Ribosomal_mL44_DSRM_metazoa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000999">
        <property type="entry name" value="RNase_III_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036389">
        <property type="entry name" value="RNase_III_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207:SF32">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11207">
        <property type="entry name" value="RIBONUCLEASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22892">
        <property type="entry name" value="DSRM_MRPL44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00535">
        <property type="entry name" value="RIBOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69065">
        <property type="entry name" value="RNase III domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RNase III" evidence="9">
        <location>
            <begin position="105"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="DRBM" evidence="8">
        <location>
            <begin position="299"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW92055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="400" mass="44265" checksum="07A72F7DF8C3FB4A" modified="2019-01-16" version="1">MKRLQLGRWSGQLLCPRTRPCCLRQQQQQQVYQRLHVASSIRSQSTSSAAEINYEDGPESETLAEIDLDGPVPEFPSPLPEAALHSAKLAALHARLSLPQKLPLQTMARTLVDSTADPNVDFNNATLAQLGGNLMSYYVSEYLICKYPRIPMTVLFAATYAYNGPKTLQIIGKEWGVETAAAPGSEVDPGLLQFSKMKPGTQIPGFGQGQTRPNAHHQSNRRGVSSRVVYDDEFGDTIPNKTTTHDNVQTTELAYANFVRAVVGSVYAHAGREAAKTFVKQHILSRHLDISQLFVFKWPVRDLARLCAREDWEHPVARMLSETGRRSRTPVYVVGIFSGTDKLGEGSGPNLVEARIRASVAALKSWYLYSPGNQVRVPSDMESEDAVPWEPVHIDIGEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0U1</accession>
    <name>A0A3D8T0U1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_01586</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0U1"/>
    <dbReference type="OrthoDB" id="3026777at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="229"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="349"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="409"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="438"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW92192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="524" mass="57138" checksum="2B84EBE4748C0A5D" modified="2019-01-16" version="1">MGPREPADEQQQPLLAREEDATPHHSIIRTTHSPRVVIGIMVLTVFVLSFASTMMALPTLRIYEDIICHRYYENVSGQGHIGLEGKIDEGLCKGDEVQNELNIILGVKQFLTAVPAMLVAIPYGLLADRIGRKPVFGLVVTGYIVSTFWSLNVMWFWRTLPLRLVWLSPLLLFIGGGDVVIAIIFYSIASDVTTEENRANVFLLGSCVGSLAQIIAPSIAAALMIRSPWIPLLSGYLILILGSLTVVFIPETLHLHAAGKKDLVPDIERSPSPSRADALMKTVKAQILDGLQRFRASASIVSIPILIILLTFFNQPFSDQFDSIFPRYISKRFSWSLAKTGYLISLRSAFNIGVLVGVIPGISHILTCRLGYSNWSKDLTLAQTSVFFSAVGALVMALSPTVILTSAGLIFWTFGAGFTALCRSLLTSMVEKEHLARIYAVVAVVETVGALVAGPALAGLFSLGLKWKGGWIGMPFIGMAFIHILAGCGIWFFGVFTKGVEINGYETETDDTVVGEDGSFREIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T141</accession>
    <name>A0A3D8T141_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative pre-mRNA splicing factor prp1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_01679</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T141"/>
    <dbReference type="OrthoDB" id="440128at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000649">
        <property type="entry name" value="mRNA splicing factor (Prp1/Zer1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:001164">
        <property type="entry name" value="mRNA splicing factor (Prp1/Zer1), putative (AFU_orthologue AFUA_2G06070)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000256">
        <property type="entry name" value="Probable pre-mRNA splicing factor prp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010491">
        <property type="entry name" value="PRP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06424">
        <property type="entry name" value="PRP1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13428">
        <property type="entry name" value="TPR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PRP1 splicing factor N-terminal" evidence="10">
        <location>
            <begin position="12"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="PRP1 splicing factor N-terminal" evidence="10">
        <location>
            <begin position="151"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="730"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="58"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="154"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="504"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW92285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="960" mass="107766" checksum="1E036590119D5ED4" modified="2019-01-16" version="1">MAARRDFLNQPAPENYVAGLGRGATGFTTRSDLGPAREGPSEDQIKEALAKRAAQLGTAATAYGVPEKKDEEDDDERFQDPENEVGLFAGGAYDKDDDEADRIYQEVDEKMDRRRRVRRLVPPISISFPFPFDTAGLYIMQIDEQITDLCAYREAREKAEREEYERNNPKIQQQFADLKRALTTVSDEDWANLPEVGDLTGKNRRSKQALKQKFYAVPDSVIAGARDSTELGTTVADDGANGGDGPDGTMTNFADIGAARDKVLQVRLDQASMGSGTDTVAGSATSIDPKGYLTSLAKSQINEGEAQVGDIKRVRVLLESVIKTNPKHAPGWIAAARLEELAGKTVAARNVIARGCEFCPKSEDAWLENIRLNDNHNAKIIAANAIKANDNSVRLWVEAMKLESDSRAKKRVLRKALDHIPQSVMLWKEAVNLEEDPDDARLLLAKATEIIPLSVELWLALARLETSENAQKVLNKARKAIPTSHEIWIAAARLQEQMGNANKINVMKRAVQALAKESAMLKREEWITEAEKCEEEGAILTCGNIIRETLGWSLDEDDDRKDIWMEDAKASIGRGKYETARAMYAYALRIFVNSRKLWLAAADLEKNHGSKEALWQLLEKAVEACPQSEVLWMMLAKEKWQAGEIDNARRVLGRAFKQNPNNEDIWLAAVKLEAENDQPEQARQLLTEARQEAPTDRVWMKSVSFERQLGNVEAALDLVNQALQLFPSAAKLWMMKGQIYETEGKLPQAREAYSTGTKACPRSVPLWLLFSRLEEKAGMIVKARSVLDRARLAVPKSPELWTETVRLERRANNIAQAKTLMAKALQEVPNSGLLYSEAIWHLEPRTQRKPRSLEAIKKVDSDPILFVTVARIFWGERKLEKAQNWFEKAIVLDSDLGDTWAWYYKFLLQHGTEEKRADVIAKCILSEPRHGEVWQSVAKDPKNAGKEFDEILKIVVTKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1W6</accession>
    <name>A0A3D8T1W6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative DUF895 membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_01382</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1W6"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF59">
        <property type="entry name" value="UNC93-LIKE PROTEIN C922.05C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="179"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="447"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW91988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="499" mass="55055" checksum="929505AED8CFE4E9" modified="2019-01-16" version="1">MSDLEEKKVETTPEVSQPMEEHVASTERPTGWMYRERKVGSITIPWYASPKVQLTMVSFVCFLCPGMFNALGGLGGGGKSDATTADNMNTALYSTFAVFGFFGGSIVNRLGVKLTLAVGGLGYCIYAIALLVSVHSTHTAGFSIFAGALLGVCAGLLWTAQGTIMLSYPHEGSKGKYFAWFWSIFNLGGVIGALIPLGQNINVKSNSTVTDGTYIAFIILMFVGAVLALFLCNASDVWREDDTRVVLMKNPTWKSELLGLYETIQSEPYIILLFPMFWSSNWFTTYQTNAINGSYFDTRTKALNNVLYWSSQIIGAQVFGNALDSERFSRTVRAKSCLVVLLVLTMVIWGGGYDFAKQYTRATVASPDFVPMDWSHSGYVGIMFLYMFYGFYDAAWQGSTYWFMGALTNSGRKMANYVGFYKGIQSAGAAVMWSLDSRKISFMAEFASNWALLTFSLLCAAPLIFMKVKDHVSVEEDLKFSDETLADVVPITHPEKVAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T2A5</accession>
    <name>A0A3D8T2A5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cutinase</fullName>
            <ecNumber evidence="8">3.1.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_02054</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>cutin + H2O = cutin monomers.</text>
            <dbReference type="EC" id="3.1.1.74"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cutinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.74" evidence="8"/>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T2A5"/>
    <dbReference type="OrthoDB" id="2586582at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050525">
        <property type="term" value="F:cutinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043580">
        <property type="entry name" value="CUTINASE_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630:SF13">
        <property type="entry name" value="ACETYLXYLAN ESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="CUTINASE RV1984C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00155">
        <property type="entry name" value="CUTINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0964">Secreted</keyword>
    <keyword evidence="3 8" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017494117" description="Cutinase" evidence="8">
        <location>
            <begin position="20"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="236"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW92660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="313" mass="32369" checksum="CA244042C3B81794" modified="2019-01-16" version="1">MFLLQANLVLSLALAAAAALSERNSTCQAVHVFLARGYGEEYPGRQSVLVDAICSGLSSCDYEDILWTTSMEYGFCDAVAEGAANGLQQITAYNLQCPDSALVLSGYSQGAHVVGDILGGGNGTFFNGCVQKSNAGLDPSVVPGTKIAAALVFGDDRHTANQTYNVESGSGNQGLFPRSAAELESLSNYAALLRSYCGLGDPICAGGDINEVHWSYFDIYSDDAATWVKQMLSQNTTTSPSSSASQASTTSSTKQTTSTLLNLESPTASVSSTSVSSTATATSATTTSVSGASLTTCRISLMLLLSVVAALAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7U6</accession>
    <name>A0A3D8T7U6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">hydroxyacylglutathione hydrolase</fullName>
            <ecNumber evidence="5">3.1.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glyoxalase II</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_00400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>an S-(2-hydroxyacyl)glutathione + H2O = a 2-hydroxy carboxylate + glutathione + H(+)</text>
            <dbReference type="Rhea" id="RHEA:21864"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:58896"/>
            <dbReference type="ChEBI" id="CHEBI:71261"/>
            <dbReference type="EC" id="3.1.2.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Secondary metabolite metabolism; methylglyoxal degradation; (R)-lactate from methylglyoxal: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.6" evidence="5"/>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7U6"/>
    <dbReference type="OrthoDB" id="515692at2759"/>
    <dbReference type="UniPathway" id="UPA00619">
        <property type="reaction ID" value="UER00676"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004416">
        <property type="term" value="F:hydroxyacylglutathione hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07723">
        <property type="entry name" value="hydroxyacylglutathione_hydrolase_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01374">
        <property type="entry name" value="Glyoxalase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035680">
        <property type="entry name" value="Clx_II_MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032282">
        <property type="entry name" value="HAGH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017782">
        <property type="entry name" value="Hydroxyacylglutathione_Hdrlase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03413">
        <property type="entry name" value="GSH_gloB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935">
        <property type="entry name" value="BETA LACTAMASE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11935:SF94">
        <property type="entry name" value="TENZING NORGAY, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16123">
        <property type="entry name" value="HAGH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="10">
        <location>
            <begin position="14"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW94637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="265" mass="29190" checksum="EA9C7B9DC756995A" modified="2019-01-16" version="1">MHIQSIPMWTGSSDNYAYLVVDDKTKDAVIIDPANPVEVAPVLKAQIQEGKINLTAIVNTHHHWDHAGGNEKMLSEFMSEKLNVIGGKDCDKVQKTPANGQGFNIGDIKVTALYTPCHTQDSICWLMEDNTGKAIFTGDTLFHGGCGRFFEGSAEEMHTALNKTLAAVPDETVVYPGHEYTKANVKFGISVLQSEAVKKLQAFAEDNKETQGKFTIGDEKKHNVFMRVDDPVLQKATGTTDPVEVMAKLREMKNNFKPPPSEAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T859</accession>
    <name>A0A3D8T859_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongation factor-like 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_00493</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T859"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16268">
        <property type="entry name" value="EF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000006">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1430.10:FF:000002">
        <property type="entry name" value="Elongation factor like GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000081">
        <property type="entry name" value="Ribosome biogenesis protein Ria1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056752">
        <property type="entry name" value="EFL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25118">
        <property type="entry name" value="EFL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="17"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="486"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="509"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00081809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW94730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1080" mass="119193" checksum="181BC7A3DCDF3772" modified="2019-01-16" version="1">MPVVNPEKLVALQRNPDGIRNICILAHVDHGKTSLTDALIATNGIISPKLAGKIRYLDSRPDEQLRGITMESSAISLYFSMLRRSAPEAAPEAREYLINLIDSPGHIDFSSEVSTASRLCDGAIVLVDAVEGVCSQTVTVLRQTWVEHMKPLLVINKMDRLITELKMTPAEAYTHLSQLLEQVNAVLGSFFQGERMEEDLNWRERVDERIAAAAAKQQEKAEREAASDANGSVDTEAITTQEFEEKDDEDLYFAPEKNNVIFSSAIDGWAFTVRQFASLYEKKLGIRRNVMEKVLWGDFYLDPKTKKVLAQKHLKGRSLKPMFVQLVLEQIWAVYQATTGGDKGKGDPTMTEKITKSLGISLPAHIVKSRDPRAILTALFSAWLPLSTALLVSAIESLPSPIVAQEMRLPGLIDDSPGASSVDPAVREAMVKSKTSKSDPVVVYVSKMVSIPASELPENKRRTGLMTPEEAREMGRKKRAEIARTQAIADGREPDPLDGLTEALGPTSLEEKPDSEKLPDPEQLIGFARIYSGTLSVGDEVYVLNPKFTPAHPHNHPEPQKVTITALYLLMGRGLEPLSSVPAGVVFGIAGLEGYVLKSGTLCSQLEGSVNLASVNMASQPIVRVALEPVNPADLDKMIHGLKLLVQSDPCAEYEQFQSGEHVLLTAGELHLERCLTDLRERFAGCEIQAGEPIVPYRETIVRAEEMKPPVNKELGRGAVIGVTSSKQVTIRLRVRPLPSEVTEFLSKNSGAVKRLYSDRQAEELGQNTNESAEGAEQEDIDDNIVGGIQSLSLPEFKAQLQKAFESVKGQREIWANAVEKVAAFGPRRTGPNLLIDSTKEGVCGRFLRDASEEIHQATSDTLQPRDFSDKISYAFQLATAQGPLCNEPVQGIAVFLEEVTINPTEDETSARDSIGRLTGEVIKTVRDSIKQGFLDWSPRLLLAMYSCEIQASTEVLGRVYDVLTRRRGRILSESLKEGTPFFTILSLLPVAESFGFSDEIRKRTSGAASPQLIFQGFEILDEDPFWVPFTEDDLEDLGELADKENVAKRYMDAVRVRKGLMVQGRKLVKDAEKQKNLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8M4</accession>
    <name>A0A3D8T8M4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_00659</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8M4"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF4">
        <property type="entry name" value="DOMON DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017610674" description="Cytochrome b561 domain-containing protein" evidence="9">
        <location>
            <begin position="21"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="221"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="250"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="10">
        <location>
            <begin position="118"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="37"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW94896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="283" mass="30454" checksum="76E1610598ECECD1" modified="2019-01-16" version="1">MKLDFFSLVLVASALLGVHAQPGRSIFNQNLDSRTNRLSIPQSPLDKHFPHKRDDISPSKTQLLPRQGNDAFGGFGGGGGGGGNGGFSGGSSGGSSSGLGSGGSFQEIERLRNTYRLAHGVTMSVVVLLLFPLGALAMRVMGKWWLHATFQVLSILVLLAGFGLGVYMAEHERRLFNNTHTIFGTVLVALFVTAQPLIGFLQHAHFRRYKERGAWGYMHLWAGRILIVLGVVNGGIGLQLSREEGTAKNAYIAIAVVVGVIYILTLLITAVFRRRGSKAGSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8R0</accession>
    <name>A0A3D8T8R0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_00678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8R0"/>
    <dbReference type="OrthoDB" id="4181307at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034443">
        <property type="entry name" value="PB1A10.08"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42051">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED PROTEIN PB1A10.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42051:SF1">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED PROTEIN PB1A10.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="169"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW94915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="453" mass="49668" checksum="D0E0F90AC5DFECE4" modified="2019-01-16" version="1">MSITAATTTTTESRPSTPTSPVIIPTPSRASHESQRSQARNERPRMPRKTSDKSERRARTVHSPDAIPPSVAALLAITAIPVHKTNSARKRGGSRQRLTVDAILQHTGGMDMEKELSRSLSKSHMDFLLSPPDELEDDEFLVGSDVGMESVLSTRTMSSESMPSLDGDSALSPSPSLRSLVTPGSRGRKSLPKRHILSSSPPGDGDVEDHPLLTPKLDIEELDFRVFEKHTGDEETPIEIQSPVRKSAFKSNLTASLRALASAARLSAKSFSTLTTPMITPDDFLTRSIISIDPRVPFTDERMPPKLEDTPTPALRRYLNPTTNAPIEAHVPSSLAQTTSTTKCTASIQMQTYKVSRSARGSSPSVISRRTQPTSEDAFAEVAVGPVARQRDMRENSDFIRIAVMEMAMRKKGKLDDQKPGRARWALPPRKPSTTPYEIGENGVPVRWMGITY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T906</accession>
    <name>A0A3D8T906_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_00806</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T906"/>
    <dbReference type="OrthoDB" id="4540492at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF31">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="265"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="17"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW95043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="509" mass="55043" checksum="43D53B9B46B3B45B" modified="2019-01-16" version="1">MAPWLYGTNSYLNVALLISASCIFAVTSGYDTALMNGLNILPAYKSYFKLTTATKALLTSSTYIGSSVSCIAFGYVANIIGRKRSIILSAIVKLIGVVLMASAQNVAMFCLGRIFLGLGSGISGTVAPAWLAETLPVSFRGRGLSLIYAVWYVGSLLAAGVTYGTSSYVGDAGWRIPAALQAIFSVLCLIILGFTPESPRWLVYRGRNDEALDIIARTHSNGDMNDPVTLLQYKEIVDTLNWEKENGESLGYWEILKTKGSRKRVMLACSVAVLNSLSGNSIVSYYLGTMLTNAGIKSSHTQLEINICLSAFCLVIAMIGSQLSDKMGRRPMALISVGALTVFMFIVGGLTAGFGSGGNQSGVFATVAMIFLFQGSYSFGCTNMTTMYPPEVLNYSIRTTGMAMWTMTVNLLGLFVTFAFPFALAAISWKLYMINAGWDVLEFAYIYFCWIETRGKTMEEIDRLIDGEKHSDVPDLEVVVQGKIDVSDALANVDLVGGTKTTKAVVQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9P9</accession>
    <name>A0A3D8T9P9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Protein phosphatase PP2A regulatory subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_01046</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Phosphatase 2A affects a variety of biological processes in the cell such as transcription, cell cycle progression and cellular morphogenesis, and provides an initial identification of critical substrates for this phosphatase. The regulatory subunit may direct the catalytic subunit to distinct, albeit overlapping, subsets of substrates.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the phosphatase 2A regulatory subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9P9"/>
    <dbReference type="OrthoDB" id="6274823at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902531">
        <property type="term" value="P:regulation of intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000174">
        <property type="entry name" value="Protein phosphatase PP2A regulatory subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000189">
        <property type="entry name" value="Protein phosphatase PP2A regulatory subunit B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000009">
        <property type="entry name" value="PP2A_PR55"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018067">
        <property type="entry name" value="PP2A_PR55_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11871">
        <property type="entry name" value="PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037309">
        <property type="entry name" value="PP2A_PR55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00600">
        <property type="entry name" value="PP2APR55"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01024">
        <property type="entry name" value="PR55_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01025">
        <property type="entry name" value="PR55_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="406"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="409"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00067298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU331113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW95283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="484" mass="54292" checksum="FC35CBEEFB354B43" modified="2019-01-16" version="1">MVEGEPNSPTWKFTQCFGDKGDVDDITEADIISTVEFDHTGNYLATGDKGGRVVLFERNETKKTCEYKFHTEFQSHEPEFDYLKSLEIEEKINKIKWCRRQNASHYLLSTNDKTIKLWKVFEKSLKVVAENNLSHDLTPAGGVSGGGGVRPISNVHFNSSHDLKLPRLTHHDTVVAAVPRRTYANAHAYHINSISVNSDGETFISSDDLRINLWNLNIQDQSFNIVDIKPANMEELTEVITAAEFHPQSCNWFMYASSKGTIKLADMRESALCDQHAKQFEQEEDPSARSFFSEIISSISDVRFSHDGRYILSRDYLTVKIWDVNMERTPVKTIPIHEHLRPRLCDTYENDSIFDKFEVVFSGDAKNVMTGSYNNNFMIYPSDPDKEVEVVLQADKSAFKAKKVGVPTPINSSTSPTATNGGKKGGSRAGSPAAGAGGQGGRMRKETDADQIDFNKKILHMSWHPFEDSIAIAATNNLFVFSAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9T9</accession>
    <name>A0A3D8T9T9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_01083</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9T9"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF133">
        <property type="entry name" value="COA BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12300)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="ACB" evidence="4">
        <location>
            <begin position="5"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW95320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="317" mass="36525" checksum="76C2CF78072A8064" modified="2019-01-16" version="1">MADSVDRVFVHALNTVKKIPKTGASRPPPADRLRLYGLYKQAMEGDVDGVMDRPEGGGELEGDELKRERDKWDAWDAQRGVSRTEAKRRYIEALIETMHKYASTTAGYSGLGSFGKENTDFEVGYRDARELVAELEFVWDQIKNNSASSSGSSPGRGVPAYTTQPRQFQPALPSTEGPMRVISPMSQDDEAERESERRLGYNDGDNVEYEGAQDPRKQTKNWQSKIEKTMVKMTAEIAALREQIATGREFRDRKRRTWTNWLGWFFWVSLKHALIDVALLGLVLLWFRRRKDRRLEDLVRDWLRAARQRLREILPTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8TBI3</accession>
    <name>A0A3D8TBI3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_00901</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8TBI3"/>
    <dbReference type="OrthoDB" id="3502863at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW95138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="74" mass="8014" checksum="B57C9C63947C3AB1" modified="2019-01-16" version="1">MAPTTTTAAQVPGQDVEMAQPAIRESMNPNTPPPQQQTRDAAESEEMHLRGGEACPGRFCFIIPCPLPCNFCII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q458</accession>
    <name>A0A3D8Q458_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SGNH hydrolase-type esterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_13077</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000025">
        <property type="protein sequence ID" value="RDW56612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q458"/>
    <dbReference type="OrthoDB" id="671439at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1110">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045136">
        <property type="entry name" value="Iah1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013830">
        <property type="entry name" value="SGNH_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036514">
        <property type="entry name" value="SGNH_hydro_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14209:SF19">
        <property type="entry name" value="ISOAMYL ACETATE-HYDROLYZING ESTERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13472">
        <property type="entry name" value="Lipase_GDSL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52266">
        <property type="entry name" value="SGNH hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017616935" description="SGNH hydrolase-type esterase domain-containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="SGNH hydrolase-type esterase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW56612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="196" mass="21692" checksum="82170671C3736AF9" modified="2019-01-16" version="1">MPMQGILKLMTIFLGANDASTDPNAGQFVPIDRFKQNLVAIINHESVRAHSPKIILITPPPVEETILLETVKGFGGSEQPRKQRVTKKYATAVCEVGKQTGVAVLDIWKDFMFKAGWIEGDDTMPGSEENGKSIALMDLLYDGLHLSPAGYEAVFLSLMALIEANWPELSPERMPFAVRCDWEKGKTVQSSDERIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q4W6</accession>
    <name>A0A3D8Q4W6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12952</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000024">
        <property type="protein sequence ID" value="RDW56885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q4W6"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW56885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="32415" checksum="6DA56061AF1D80A3" modified="2019-01-16" version="1">MSSPVPLATQEGDPDSDRDSSMGDASAPNDETQNEMLDIGHHMYTLVLDNKLFLAPINPVAQNVLDVGTGTGIWAIDFADEHPSATITGTDLSPIQPTWVPPNLKFEIDDAELDWTWADNWFDFVHMRALMGSIKDWPRLFSQAFRCTKPGGYIESFEVDIQFTSDDGSVRPGTTMYDWSQMFIEAGESMGQTFQIASRSKKLIEEAGFVDVEEKKFKLPVGAWMQDKKWKEIGRWNLLYLTTGLEGMQLWILKTVLGWEYTEIQALSGKMRSAFLDRSNHAYYEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q4X1</accession>
    <name>A0A3D8Q4X1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Purple acid phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_12938</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10 4">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000024">
        <property type="protein sequence ID" value="RDW56871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q4X1"/>
    <dbReference type="OrthoDB" id="45007at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039331">
        <property type="entry name" value="PAPs-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025733">
        <property type="entry name" value="PAPs_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953">
        <property type="entry name" value="ACID PHOSPHATASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953:SF145">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14008">
        <property type="entry name" value="Metallophos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017494597" description="Purple acid phosphatase" evidence="4">
        <location>
            <begin position="23"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="7">
        <location>
            <begin position="31"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="177"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase C-terminal" evidence="6">
        <location>
            <begin position="408"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW56871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="491" mass="54352" checksum="C85829E05949BFCC" modified="2019-01-16" version="1">MRFSSSVGAAVAFVALAAPAQALQYNVSLNSQVRMAFNGQTGMTVSWNTYEQLSSPTVMWGCSPNQLVNKATSDVSITYPTSLTYDNHVTISGLKPNTKYYYMPLDMLKDQYTRGPYSFTTGRVAGDMTPYTAAVVIDMGTFGSEGLSTTPESGVAANNLLKPGQQTTIGSMTKSADSYEFVVHPGDMAYADYWLKEEYTGYINVTMADGYKAYESILDAFYDELTPITTQKPYMVGPGNHEANCDNGGYKTWNTSICVPGQLNFTGYSNHFRMPSEKSGGVGNFWYSYDHGMTHYVIVDMETDFGNGISGPSEPISGPFGQTNEQYNWLENDLKSVDRSVTPWLVVFGHRPWYTSGEVCLECQEAFEPLLDQYNVDLYMSGHNHYYERIAPIANNVTDPNELNNPSSPWHIVNGAAGHWGGLDSFDTTMQNYSRFGLDSTEGIYGWSKLTFHNCTHMTHEYIASVNGTVLDTATLYKQRTCGVSNSTCDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q559</accession>
    <name>A0A3D8Q559_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Acid protease-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_13009</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000024">
        <property type="protein sequence ID" value="RDW56942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q559"/>
    <dbReference type="OrthoDB" id="4074350at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="414"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="4">
        <location>
            <begin position="29"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="446"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="448"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW56942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="537" mass="58248" checksum="4F4BC573AF36992D" modified="2019-01-16" version="1">MTSTVQSVPAPMSISTSQAWDDDGAGSWSTFILEIGTPAQPARVLISTASNEVWVVAPEGCPSAYGSDCANQRGLEFTSNKSSTWSSIGLFELNLETNLNYSGNGDYGHDNVSLGYPGSGGPSLPSMNVAGIATTDFWIGHFGIDPEPSNFTTLNDPQPSYLDTLYKKSMIPSISWGYTAGASYRYNKVPGSLTLGGYDTSRFGQSNLTLDFYPDVARRLIVDLTSITYTPTGGLSVGSASTLMLQTIPMFIDSTVPYLYLPQVVCDQFESAFQLQYDDMSELYTINGTAQKILTTMNPSFTFTLADTTGQTLTITLPFLAFNLTASFPLVQSETNYFPLKRATNNTQYTLGRAFLQEAYIIADYQRSRFSISQCLWPASFTENLVAILPPDGLNSSTNTTTTTTANKSAPTGAIVGGVIGGVVVIIIFIFVGYLFVYKPAQRRKKSPSTLEGATDTTEPKPELDATNQDTAKLTSNELDGDGFYSPVSHIQETCTHQLEDTSRGEHKIESPGEFRSELNSTPIYEMAARELVGNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q5X7</accession>
    <name>A0A3D8Q5X7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_12671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q5X7"/>
    <dbReference type="OrthoDB" id="2309723at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03188">
        <property type="entry name" value="GST_C_Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03057">
        <property type="entry name" value="GST_N_Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF8">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE GSTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="108"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW57221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="233" mass="25482" checksum="09019D14DCCE2A49" modified="2019-01-16" version="1">MDRAKPSPDKTPADQASSTVVPQLEFYYAPGACSLAPHILLHEVGLSFDAIANEVTRHSANFIEGFHRINPKMRVPVIALDAEVITETTAVVTAIANLAPEKHLLGQTPLETLRVYEWMSWLSGTLHGQGYGGLARPERFSDDPAALDGIRAKGRKTVVDCYDMIEGKLTGVYAVGDSLTVVDPYLFVFFRWGNGLGLAMKEKYPNYAMLVSNLVERSAVEATLKAENIDSTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q770</accession>
    <name>A0A3D8Q770_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7779 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_12483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q770"/>
    <dbReference type="OrthoDB" id="6161812at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056681">
        <property type="entry name" value="DUF7779"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35205">
        <property type="entry name" value="NB-ARC AND TPR DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35205:SF1">
        <property type="entry name" value="ZU5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25000">
        <property type="entry name" value="DUF7779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7779" evidence="2">
        <location>
            <begin position="647"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="314"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="341"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW57682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="967" mass="108486" checksum="4AE5FB0C17C3EEEC" modified="2019-01-16" version="1">MNDEIFPKPIESLENADRAEVLQLVYATPESPSLGLDVVFIYGVRALDVTGVPSGWLTSLTKLVPQNSSIFAFNLAYRADNGFMWQDIVGKAGQLLEALFLKFHGCTRPLEIICYGFAGVVFKHTLWRAYQQHRYRTSIVKAISGIVFLATPHITKSELEDVRTLSMILQGDMRSGTKRGLAKADVSKLAYSSVQFEELKVQFPILSCYETRETKLRSSKWGSKKEILVSEQLSKTSASREKLVGIDARLSEIFLNTDALIHLHIKKCGTLCLEYAVARAKENNFENRRQTLAHGHQNTPQIIYSPLVAPCHQQTSGSASPISSPQSISPYLTGERNRNLSQSSSNQTSYTGSNSDSSLEIVKPNVKLPAYYFKPGTVTRRNVDFKGRIDKLKEIDDLLIPKKPRNSEEDDDIEDLGHRIVILCGPGGIGKTQLGVEYMHTRKTQFDFIGFIQAESRERLTNSFVGIAIKLGLRFQNSHQDPRITIDNVKSWLEDTPGVRWLLVFDNLDRQDIIQEFWPDEGNGSILITCRDPITLINYGHGSTSINLDMLPLSDAIDLLFKMIQDVVPPIGQGHSKSNTRNDAEAVVRALDCFPLAIVQMAGVMREYNLNLSQFLRFYREEAHRVGFLGSGGPNPHGYNLNLATTWALAKLSRGARCILSVISLLDPDGIPEAIFTADPQKAGLLEMPSSETMYLAMRELTRSSLIALTRIQEHQENEIVIRRVAQDIVRALLLKSLDAEKDAFCKTFAATATLLKTVWPSILGGSQFGYTTSYKVDRWPECSKYLPHIIKMLYIFKNNISEEDRAKSATRPFAWLLCEAAWFENERSNVQEGLDLARATIWMFDYMDKSSLSDVESIDLRATAYGTMGVLAQLADKPEDALYYDELNLKLRQEAYAITKEVDATLAAGYGHLAEALALNGLFGKAKEMFEKSIEVRRQMPNFTPLQLFTPLLGLGQIACYERNYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q793</accession>
    <name>A0A3D8Q793_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dihydrodipicolinate synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_12472</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q793"/>
    <dbReference type="OrthoDB" id="191315at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008840">
        <property type="term" value="F:4-hydroxy-tetrahydrodipicolinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00408">
        <property type="entry name" value="DHDPS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002220">
        <property type="entry name" value="DapA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12128:SF47">
        <property type="entry name" value="DIHYDRODIPICOLINATE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00701">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00146">
        <property type="entry name" value="DHPICSNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01130">
        <property type="entry name" value="DHDPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW57671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="330" mass="34959" checksum="C91AF612A3214B0B" modified="2019-01-16" version="1">MTSQIPNKSTPLPPGVYCPVLSLYKTTARQEIDLEASYNYFKFLILGGVTGLVLAGTTAEAVLLSADERVELTKVAKKVVTDLGLPDYPLVAGISGQSTNESIRLAEAAKEAGADFGLLLPPSYWSKVVTKDVILGFYREVADASPMPVVIYNFPAVTAGIDLDSDIIAELAEHPNIVGVKLTCGNVGKLTRLTADFNPKQFAVYGGSSDYLIPALIGGGSGCVTGIGNVYPKSVSKLYALYQEGKIAEAAKLQGLVAHAEKACKAGIAATKYGAAYFAGPVAGVNDKASFLPRKPYVPANETMQAWVVKTMAHLEKVEKELPDRQCPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q7J4</accession>
    <name>A0A3D8Q7J4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_12593</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q7J4"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052073">
        <property type="entry name" value="Amide_Lactam_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171:SF4">
        <property type="entry name" value="ACETAMIDASE REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47171">
        <property type="entry name" value="FARA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="101"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="438"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="701"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="710"/>
            <end position="719"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW57792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="814" mass="91936" checksum="FC63CA64DA236EEC" modified="2019-01-16" version="1">MPIRTQGIGLSSGDSESAEVDIPDIVDKKTITLMLEEGRRGSQSLLAEPEVEAHYKLAFLRRGWAVYILRFFRKRRRRQDLSAVEPHIMEQKQQQHPGERRQGYAACGNCHQRKIRCDVGCLIRPYPSTALSSDEGKSRKYGFPCSNCISAQRLDCRVHVKKKRLAGPRRAGGIPVPIVRASDDATHLPSFEPASTGATHCRHIPSIGAYSSTDNHIPSYEKPAHDDQDSISSAGESVSLDFARDNRAPGVERQLVDFIDQENLGKRSIQRGVRIIYVGEDVSNLNFLVRQRDGGDNDAVHHFPSDELGKRHLAYEPERTPKEAFVLPHRALADELVHAYFKHVNPICPLVDEEIFLRQYRSRDTTDAPSLLVLQAILMVGAHVSRKMPERETLKATFFRRAKLLFDARLEKNRDLVVQAALLLTWHSDGAEDICANAWHWIGIAVRTASGLGMHRDTTPSTLNAHDKRIWRRIWWIMVKFDVIISLVYGRPQAINLDECDVQPLDISDFEGCGSRAQAEYTIQYVELCVIISKVVRERFGLRISPEKRKIALSNADEALANWALNLPKHLQLKSSTTHLWFADLHLTYNNFLILLHRPNPRKGFNDHGPNDSDICSAAATTITNIFEDMRENNRINCVWFAGVITLFTAMIQVSVELRFSNPILAIAALRRMDSSLLSLRELSEYWVHAEPILRLFEESSHAKPGIRSTEPQGSSNSGLHDATEVAQNVLGPHSRGQTDLDVLAAAANVAEKPGGQYGNKDQLPLDWRYFQDGIPGQAMPSLGDMMTLENEWREIYWQEPGIARFLEVDFRNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q7T2</accession>
    <name>A0A3D8Q7T2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_12489</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q7T2"/>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="212"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="735"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="768"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="801"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="837"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="870"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="903"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="936"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="969"/>
            <end position="1001"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW57688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1046" mass="116953" checksum="9659C4BAADE52592" modified="2019-01-16" version="1">MGKALLFADRSDDSERREILLSTRALFFFGTPHSGSLFSKPGESLRNFVKAIGFDTAGQNLQVLQPDSALLEQNRDDFFRLYTRAKSFEICTFQEQRGMKGISIGGLNDKVVPDTSSEFPGSENKFPILANHMMMCRFSGAEDDGYKQVSREIKRAYNKAGRDNARTKSSERLPALSETQLTIVCKPAYTDSLWFPEMNERQRQVEEVPSESYSWIFDDENYRNWKDDGYGLLAIRGKPGTGKSTLLKKIYSSFKKDNTEVITLAFFFHRRGILLQKNQTGMFRTLLYQLFTQAPFVAGEFGTIYEERCRRQGKPGQDWHWKFDELKEIFNSALLNAAKHCRIRIFVDALDEAQAEITAARDLTQENSNELSKDNAETTAQMVANYLYKINGKLRAERTATSICFSCRHLPVVRVAEEEYEVIVEDHNYNDLWNFTRNELKRKLAGFKGKAVPTEVQDILHKTIVEKSANIFIWAVFVLPFITRLYNERKPLEFILQRVNSLHTDLHQTYREILQEVINPEDRPATLHLLQWILLAMRPLSVTELRYALVSDDSRIDPSEGSCEDIEEFVHEDDEMEEYIHVASGGLAEVQVHYDKGFSPDSVGQEAGSWKVVQFIHQSVSDFLSTDQFRCLELKSVEVELGRGHQRLSRSCLNYLDSADTVQSIEQGPSLTREKLPFVSYATKFWHIHGEKAERAGISQADLLQRFEWPSKRLVSSFETLTDYLEGPREFHIGHGGSLLHIAAASNLQTTVEELFHQGANINETDNDGNQAFFYASRNGHRSMVELLQKHGADIEYWNKQGENALYIAAHHGQYLVVQMLLQLHMNPNAASPTPSRFKNPLQAAASIGSEPVVRLLLEKGAEVNAQGGQYGNPLQAAATIGSEPVVRLLLEKGAEVNAQGGELANALQAAAYRGNEPVVRLLLEKGAEVNAQGGELGNALQAAASHGNEPVVRLLLENGAEVNAQGGELGNALQAAAYGGNEPVVRLLLEKGAEVNAQGGHYGNALQAAAAAYGGKPVPVVRLLLEKGAKANAQGEKYGNALLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q812</accession>
    <name>A0A3D8Q812_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_12638</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q812"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="333"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="4">
        <location>
            <begin position="624"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW57837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="838" mass="95756" checksum="9D2C622244867880" modified="2019-01-16" version="1">MNSSPGSRRNDLPRLYPVYPPNNSTENTNVDIVAVHGLETWSPRTWIGQKDYGTPNAGKEVNWLSDPDMLHENIPGAKIWVYDYNSNYSRDAPETRLEDVGSLFLDSLMAEEIGKRPLVFIGSCFGGIVIVQALVKAHRNEKTYTSFLHSILGVVFLGTPLRGTPLTTAAEREIFVRGILGETTSSKTLLSEIKELSNTLEALVDDFADMARELNYEIRCFFETKKTQIIRRVFRSGPLSNLEVPGAESQLLVTRRSATLDGYPKTAMDVPHVMMNKFTGPDELRFKVLVKEIKTIAEATRRHRFDKEEAKILSSLFSDYEAGKDANPDQVSGTCLWFIDHPNFTNWRDETSETAAKLLWATADPGCGKSVLAKTLIDKSLLSTETIHVTTCYFFFKEDDTSRNRGIHALRSILHQLFMQKPELIEFAKSDYKTKGESLFSTLTSLWETLERCATSLKIGKIICVVDALDECLETDRYLLIRLLRELDAPERRTKKNLKVVVTCRPYHDIVGAFNDSTYGNRSIRLEGEKETEKIRKEIDKVIEHEISRIVSRQDSQFDHEVQQALIKYLKDMEHHTYLWLHLIMEELRKTLEYSTPELLGLLRSIPRNIEQAYENILKKVDRNHKKEARQLLSIIVAAVRPMTMKEMHAALGIAKKIRTKKELGVTQLAQSREKAFEHRIRNLCGLFVNIHDSKIYLIHQTARSFLIDLPESNDSEDKDSDSSASPVAIVPHPSLRAERKWKHSILMKDSHRLLADICIWYLQLPDFEFKNTFPGGQATNVDNRGFDSVVSTIITRYEFLQYSAKNWPIHFRGAFVDQDQSYTASALQLCDTESQHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q977</accession>
    <name>A0A3D8Q977_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oleate activated transcription factor 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_12261</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q977"/>
    <dbReference type="OrthoDB" id="4934715at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF49">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="306"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="67"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW58331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="700" mass="77960" checksum="904B60909C577F18" modified="2019-01-16" version="1">MRCNRQSPCSACLRRGKPAECIYTSSEQERKDAIDYRPHAGGQQARQRVARLEKLVTQMRDQMRVVEQTSGSVSGDTAPLNEYAEDPVLPDTPGDGNVGDSVGKLSLTDDQTVYHGSTHWGTILEEIQSLKDELSDDYSDAGMSQESTPFDPGSMVGSSPTRISLLSSSPSLPKEEILAMIPPRKIVDRHVSNFFNAFDFASSILHRDRFLVEYSNFWQNPSAVPVMWIGLLCSIMSISAFLQLQEVGAPNSYASETQETLEAYRTLTIHCLVAGDYLRPTRYTIETLTLHFAVDQNTNLDPNIGNWILIGVVVRIALRMGFHRDPSHWPSIRPLEAEFRRRLWITLYHMDFFTSTQVGLPRIIKDSQCDTRAPANLFDNDLSFEHDVMPPERPLTDATPFSHIIQRHAIIKIAAEIYDATEAGPPSSATIAALGVKLEKAIDSIPERSKYRPLEISVADSPVTILHRMFIDILTHKATYLLHRRSFTKSFVGEGNTNSSGLCINAALAILEHQRRMNEESQPGGIMSGIRWKISSSLNHEFLQATMMLCFALNRFHERHTDPTDSYDLPRRDEIIDALTIAKSLWEKQANLSAEARKAGIAVNAVLKQNSNILSPPSLPALVGLVDPLRDHSTLIGQSTGLCDQMPGVALQNHLVSFDFGQNMIMDPTFSTLDSDMGAYGSLWDDFLSEPMDGNQPGIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q9U1</accession>
    <name>A0A3D8Q9U1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="6">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BP5796_12357</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">BP5796</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 21">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="6"/>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q9U1"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF8">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_7G06410)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="20" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="16" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="17" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="19 21" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="11 21" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="18" id="KW-0456">Lyase</keyword>
    <keyword evidence="15 22" id="KW-0472">Membrane</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0964">Secreted</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="9 22" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 22" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="22">
        <location>
            <begin position="178"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="RDW58427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="543" mass="59850" checksum="B007C634808C2AAE" modified="2019-01-16" version="1">MAQPAPTPSSSFPLKNAYLVLYNGLSLCLRAWILFCTLRLWSSHGNGAVWEELNSLARWTETLTTIEVIHAATGLVRAAPTTTALQVAGRNTIVWAITRNYPDVAAREWAYSSMLVAWNAADAVRYAVFALERGLGRVPSALVWLRYNMFFVLYPIGILSEAWLVYQVIAPSRSRNLAYQYLLYLGLAIYVPVIRKCVVIPSGDGSDDVPAILEAFQNCGRGGMVKFLNETYHIESVMNTTELRNCRIDLKGTLLWGTNISYWLANSLPMGYQNQSTAWLLGGENIAFHGYGFGTFDGNGQVWYDFINGQSNYPRRPHQLTITGTTDSSFEGLRFVQSQMWTMTVIHSRNVLLQDIYVSSRSTSGTSSVNTDGADTIYADNITFNRWMVRNGDDAISPKANSSNIFITNSVFYDGSGIALGSIGQYNGVFETIENVTADNITCINTLHAVYFKTFTGEQVGYPPNGGGGGLGHIKNVNLCNFKLQNVRNTAISVTQCTTFNGAAGDCNSSEFEIEDIKFQDVAGTLNEDPIAHFSCSGAMPWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QAK4</accession>
    <name>A0A3D8QAK4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_12434</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QAK4"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW58504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="38460" checksum="65A85558832B7D41" modified="2019-01-16" version="1">MSSEPAIPTGLVVEAEALIGDEDSTFEDDQESTISLSSSIRGHVYENGRRYHAYGEREYLAPNDEAENARLDMHHHLATLLINGKLHVAPIGQHPQRILDLGCGTGIWSIDMGDAYPSAEVIGVDISPTQPSIVPPNVRFEVDDIEHIWTYRSQFDLIHARFLAAAIADWPKLVGQVYEFTKPGGWCEFKDWDLQIYSTDNTLPKDSHIQRFHDLTLDALEKLGVVHSPAPKLKGWVEAAGFQDVHEDIEPLPIGSWPKEKRLKEIGIWNRAQFEDGLEAICLRLWTSVLGWNKEEVQLFLVEMRKELKNKAIHAQWKYHIVFGQKPRHRSGTSEEDST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QBD7</accession>
    <name>A0A3D8QBD7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12086</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QBD7"/>
    <dbReference type="OrthoDB" id="3636801at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017634459" evidence="1">
        <location>
            <begin position="22"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW59162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="435" mass="49411" checksum="772FF95209B2A9E3" modified="2019-01-16" version="1">MMKMWLVCGFVFLSSLTCVLAWSDWAELMPDAVMDFIDNPMRRSRIPQFILDARHPWILENKRKLESLPDAEAFLCGLNGPSDKPDVHVNNGLEIPGDLFHHLEIDNNRYGISRPGWPNALRRLREMKRCPQALALVKTFTVNIYVHDQYSDWFLRVREPSRPQIESLKLFGDVLEAMTGLETLKWELSAEHAHWFEEAFKHRDLTLPSPKHLLIGPLSHYLVGMCPNVEAIEDIELTCWKHSPHQSPGLLLVRSTSSARNLTRLALHACFEGWTPELSREVLEYMPQLTSLGLKNGFEPMYIDAAYTLNPPRPEGKLLRGVLAELANFPNLTHLDLPASYQLDLGFDGGPMCGNAYEGPDGTRYQREVLAEAYKATELGGAIVAEVLPHLTSFTIGGYQPNITRDEGVISNVTWPWTGHLDEWLMVRVPDHDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QEB6</accession>
    <name>A0A3D8QEB6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ureidoglycolate hydrolase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_11584</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(S)-ureidoglycolate = urea + glyoxylate</text>
            <dbReference type="Rhea" id="RHEA:11304"/>
            <dbReference type="ChEBI" id="CHEBI:16199"/>
            <dbReference type="ChEBI" id="CHEBI:36655"/>
            <dbReference type="ChEBI" id="CHEBI:57296"/>
            <dbReference type="EC" id="4.3.2.3"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW59978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QEB6"/>
    <dbReference type="OrthoDB" id="10266039at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004848">
        <property type="term" value="F:ureidoglycolate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050385">
        <property type="term" value="F:ureidoglycolate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000256">
        <property type="term" value="P:allantoin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20298">
        <property type="entry name" value="cupin_UAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.480:FF:000002">
        <property type="entry name" value="Probable ureidoglycolate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.480">
        <property type="entry name" value="Ureidoglycolate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047233">
        <property type="entry name" value="UAH_cupin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007247">
        <property type="entry name" value="Ureidogly_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024060">
        <property type="entry name" value="Ureidoglycolate_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21221">
        <property type="entry name" value="UREIDOGLYCOLATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21221:SF1">
        <property type="entry name" value="UREIDOGLYCOLATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04115">
        <property type="entry name" value="Ureidogly_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0659">Purine metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW59978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="253" mass="27204" checksum="2791CEE7A390C3DE" modified="2019-01-16" version="1">MPVEIEAPPRISILKTRPLCQDEFSSFGTVIENPAPSLVPSSQITDLPPNAVQANQGSALKYLNVTHMVDLYTLAPSQQAAKPVMNMFVCAPRSLLPSVNGEVDGHFEVKILERHPYTTQTFIPLGLSPLEYGEASYLVVVAPSLAASTADERLPVPEATSEFSNLPGRGLPDLSRLQAFIANGSQAVTYGAGTWHAPMVAIGRKPIAFVVVQAANGVALEDCQEAEWKSKEDARLLVAVPKLKVSSKLHPKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QHP3</accession>
    <name>A0A3D8QHP3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_11244</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QHP3"/>
    <dbReference type="OrthoDB" id="3541716at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW61352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="112" mass="12908" checksum="7ECCF185884D6785" modified="2019-01-16" version="1">MGVVKHEYSTPKKARFFHYLELGYNQAAAAKEIGINKSTASRWVQRGTERRTRPQSKNKLGRPPIVSEEHVNQMVLWITGYYNRRVLSLETIAKEACGIKANYTTLLRAWAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QIK3</accession>
    <name>A0A3D8QIK3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphatidylinositol-specific phospholipase C X domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_11554</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QIK3"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF116">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017628511" description="Phosphatidylinositol-specific phospholipase C X domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW61662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="389" mass="42857" checksum="0E58FD73B2B1485C" modified="2019-01-16" version="1">MLALLVTALASLSAAALASPTYANTTSLADLALQKVLQDAAPMFGSYAASSAKTASWMASIPDSTKIVHMNIPGVHDSATWNYSVATQTSLDHVTALDGTTPAPPEYYRCQEKSMIDMLNAGIRVFDLRYAFDTTNSTLVFWHSEALLSETATVDDVMFGFYHWLDDHPTEALFLSFQYESSTTLYGSNDAAVQLELFATLTSPAAQKYILQTKDQFGTLGEARGHITLLRRFDFDQLPAEYEAAIPGVHFSPTLWTDNSPDITLVYNAAQNLTAYVEDFYGIDAPIGTNASLNIQWKYNATTAHIQKATTMYPDSLFWTWASSEYTSNIPPETPKIMALGNGTAYTPLGGVNQRLIPFLQQQKGKRVGMVMFDFYDMPSNLVETLLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QIL7</accession>
    <name>A0A3D8QIL7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RraA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_11565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QIL7"/>
    <dbReference type="OrthoDB" id="1476984at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047443">
        <property type="term" value="F:4-hydroxy-4-methyl-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.40">
        <property type="entry name" value="Ribonuclease E inhibitor RraA/RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254:SF28">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605493-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW61673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="27225" checksum="8BEE652CB3FF52EE" modified="2019-01-16" version="1">MKIDESKVASTLLNPNYFFSFKIMASLTKASRATLKSLEGFSSCDVSDALVKLGVKYGGFLSGLTMWSPGRQSGTSKIFGSAYTVQMVDAKDTTSPKPSVHFADGIPRHSVVFVSQPKGLHTVCWGGLMSTRAKYLGAQGVIVDGNFRDVNEHRDLGFPLFARGISITGSAAATRSSTVNEAVKFTSDVQREPLTINPGDFILGDADGIVVIPPTLAEQCLELCKERWVIDEKTRTALENGAAMGPTIAKLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QIR6</accession>
    <name>A0A3D8QIR6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Annexin ANXC4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_11452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QIR6"/>
    <dbReference type="OrthoDB" id="2134400at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005544">
        <property type="term" value="F:calcium-dependent phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001786">
        <property type="term" value="F:phosphatidylserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.10">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037104">
        <property type="entry name" value="Annexin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502">
        <property type="entry name" value="ANNEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10502:SF107">
        <property type="entry name" value="ANNEXIN ANXC4 (AFU_ORTHOLOGUE AFUA_3G07020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47874">
        <property type="entry name" value="Annexin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="275"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW61560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="755" mass="87223" checksum="32A9059ADAC4998E" modified="2019-01-16" version="1">MSLDPRDSHRRGRSKSPGRERERSRSRVDEREHSRSRVIERAPSPPASRYDERDYDDYDDDPRDHRSSRDPRDPRYVTSSSSKYRGTSPMPGGYVDDEDDVKPRRREKEYLAGDKYARDDRRRGASPARGYGDSDAYKYEVESKTREREREREREHEREIEKERERDRERKRERERERELEREQEREREREIEREKEFRAEYEKRFEAERLAREKSASFHLSGGMNLGRDRHSPPHRGYSPPTYSQPDPLAYGAVPPEIKAAGGNMTYADPKQWQYAQPSEKVTYSSRDGREKSYYSSSEKERSRHNSYAGPPPAQILTVEPGSRHHRDPSPGGLAPRMHSLSVSTGHHGGAGISIATAPGSPLLEAYHGTYQSISPMPSPLMIASTPHSGLDIVESISPLSSDDERGGYGKKKRSARFHDPQEEAVVLAKALKGEKRAPDTGPLVEILPSLTHEQVMDLRVEYKKIVKTGSEKKGVNIAKHIKMRLKEEDPLLMKACYVCALGKWESEAYWANFWYQGEKSRRELLIESLMGRTNYEIHEIKDGFSDKKYSDSLTKCMKTELKEDKFKKAVLLVLEEKKMEDHPSYGLDKQLIQEDVKDLHKAVRSEKGGESAMINIIVVRSDAHLREVLRLYESTYRSNFAREMLKKSGNLGELLAHILNGVINKPVRDALLLNHALTLSKSDSIRTELLISRLVRYHWDRLHFEAVKREYRNRYGTDLQRAVADGTRGEWGRFCEMLCVRRMGDEVKYLAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QIX9</accession>
    <name>A0A3D8QIX9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_11286</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QIX9"/>
    <dbReference type="OrthoDB" id="5416589at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034965">
        <property type="term" value="P:intronic box C/D snoRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000294">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, RNase MRP-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="entry name" value="Alba-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014612">
        <property type="entry name" value="Pop7/Rpp20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020241">
        <property type="entry name" value="RNase_P/MRP_Pop7_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28256">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28256:SF1">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12328">
        <property type="entry name" value="Rpp20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW61394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="183" mass="20153" checksum="E327A7D72B7E5DC3" modified="2019-01-16" version="1">MAKEGQTPGSIPKPRPKKLERLPKDKKIQKRPLLHPSIAGVHSSSKTARIIYVSSKTPFISALKRAQKYFDASSKTPGIKLSAHDDRANLRAIEESVKKQQMEGQVVTLKGTGKAIEKVLQLGMWFQDQDAGARFAVTWRTASVGAVDDVVQKGDQGSEEGTSFVEESRIRRVSVLEVDVSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QL38</accession>
    <name>A0A3D8QL38_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative sugar transporter-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_10835</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QL38"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="65"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="1"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW62533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="421" mass="46880" checksum="B3C9D6A6BB3C7A4C" modified="2019-01-16" version="1">MVGRIINGVSMGIEANNIPMYMAELSPPSIRGSMINMYQWWLFIGAIIAKVVIFKSNDAWLNSQWAWRTVLIVQFAVPILLLGVVVYLPESPRFLVRKGRFEEARKSLAFIRRGAATEEEIEEEFQLTCLAVEEQQENHKANTYLDCFKGTNGRRLMIAVVCQLIEQLSGNAFMTNYAVIFMAQVGINNPLRSNIATICMGIAGSTLAFFVSDKFGRRPLMIGTALGMWVGLWVISGIVGYLPGGVPPGGPLSQFCLFLLLIWSLFSNLGWGSCVWIVTAETPTLQLREKSMSITTFISFLSVVIVTYISPFIQNDPGYLGVRIGFIWGAFSLLGAVFVYFCVPELSGRSLEELDELFNEKVSARKFHDYVCSGTGARITEIEDKNANMYAHIIQGQDKELSRDAKTPRAKIEEPAGKSMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLY1</accession>
    <name>A0A3D8QLY1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">A-kinase anchor protein 7-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_11079</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLY1"/>
    <dbReference type="OrthoDB" id="277832at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019510">
        <property type="entry name" value="AKAP7-like_phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009210">
        <property type="entry name" value="ASCC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13360:SF1">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10469">
        <property type="entry name" value="AKAP7_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A-kinase anchor protein 7-like phosphoesterase" evidence="2">
        <location>
            <begin position="12"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW62777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="287" mass="30695" checksum="06160396B6A3519E" modified="2019-01-16" version="1">MPPKATSRPPLTHFLCLPLVTRDSKPQLQKSLEGFASEITQKADPATAPVGARIGVPGKAVRPVGTLHLTLGVMRLTTQTRVDEALTLLQSINVHELLGNFRLGGKGGDGAQKGDPNPAVSTEDAGVQHQGPKHDSAAAEPRKPTTVHPLQISLRGLTPMHSPASTSILYTSPVCRTHDLPSLCQSLVSLFRAAGFMLPDARPLLLHATILNTIYVPKVGQASGRAGHGKHKAKLTIDATDVLERFAEHVWMEDCVLQKVAICRMGAKVMEDGGEEYFEEGALALPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLZ1</accession>
    <name>A0A3D8QLZ1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_11089</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLZ1"/>
    <dbReference type="OrthoDB" id="5426563at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="336"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="559"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="572"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW62787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="830" mass="92084" checksum="64A11296E90DD906" modified="2019-01-16" version="1">MEKHALEGRNSSSATLEELEVPRLITGNTLQTSRSTTKPASTRALELSRIFGMNWTGGGLANTWRVSRSGKGVGLTEQQKKHFAKVRSTTAAPKRPPPRASVVDSFQAKWDHRSGLSPEHHAAAFTPHRPSPSVQDESPAKEDYYSATPLPQRMKRIKLNKEGNQSRETIGKEDVADPTEKRHNMLSKDDWGLGLKVLQPPRHLYKRPAQDKTIGRRRRPLDGHRARFEQRWQPNTESARMITYASHHKTHRGDVTPTTYMQSDMRISIGSIQPTNSAKFSPEASIHRRDQRAPSEIMMLDTFERTNANKKSLSSNVSATYWDGLPPSISNHSSDAFTGFESWESPRSRGQPDTGRDSRRAMEIADTADTSESYRSWDTPLGPSIKHDGSLQHSHPSPKKFQTSRSNHKSRISHSETKDCPKKVNTSPPAGIHHPRPERNAARKFLSRNNQFNSGSEIDSTAAELGQAKPVVNSSQELENEIWNTWLIPSDDEESREYKSDIAGEVSISPGASAARFYSPTDELQRKPGGTFQERETLESGASLEDTCSIQCETDIATPESTSGSSCLQNKTGAANAGTATSNSHIISPSQPRAQPQSHLDLTSFTYVPGITRSEQSNLSSSTSSNSRLEGSLMSNNAKQAVVSLEPLASIPRKLLEKRRKGSPSYPEQDHDSLLVETSLKAQKLTKSTLSEGVKGLRSSKMRGSQLSENLSESRRNALLCRLQERRAQPEQSSDSWTQDMIGSQNSGDASPFSESLRVQASDENHAEIPTPQARTLFSRPKPFVGREVSSQEPLYIGRKLAVANLRRQKVRERDIHDILGSLVESIEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QM19</accession>
    <name>A0A3D8QM19_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">p-loop containing nucleoside triphosphate hydrolase-24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_11147</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QM19"/>
    <dbReference type="OrthoDB" id="545683at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01899">
        <property type="entry name" value="Ygr210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.470:FF:000001">
        <property type="entry name" value="GTP-binding protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013646">
        <property type="entry name" value="YGR210-like_G4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF1">
        <property type="entry name" value="OBG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08438">
        <property type="entry name" value="YGR210-like_G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="5"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW62845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="416" mass="45035" checksum="ECB11BA61B35DEED" modified="2019-01-16" version="1">MPRDPLIGLVGKPSSGKSTTLNSLTDASSKVGNFPFTTIDPQRAIGYLQISCACSRYNLSERCKPNYGACIDGRRSVPIELLDVAGLVPGAHEGKGLGNKFLDDLRHADALVHVVDVSGTTDAEGKATRGYDPSQDIVWLRSEIVQWIRGNLMQKWGSIKRRHVAVKATAVETLQGQFSGYGSTASVVARTLDKLALKEPLEHWSDETIDKVVNAFTDEKFPTVIALNKIDHADADKNISKIAKMQDPQSIVLCSAISEVFLRKLAKQGFIRYTEGSEFVDTREDLIADGDPEGGGLKEMDEKLKTRIENLKDMVLYRFGSTGVVQVLSRAAELLGLVPVFPVRSISSFGSGASGSNAVFRDCVLVKKNTTVAEVAKKVMGDAPLAYVEGAGGVRVAEDHIVAVGKNDILSFHFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQG1</accession>
    <name>A0A3D8QQG1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal protein L37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_10537</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic ribosomal protein eL37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQG1"/>
    <dbReference type="OrthoDB" id="10259236at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000001">
        <property type="entry name" value="Ribosomal protein L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00547">
        <property type="entry name" value="Ribosomal_eL37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001569">
        <property type="entry name" value="Ribosomal_eL37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018267">
        <property type="entry name" value="Ribosomal_eL37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01907">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01077">
        <property type="entry name" value="RIBOSOMAL_L37E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW64035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="93" mass="10315" checksum="83C9BD651D778295" modified="2019-01-16" version="1">MTKGTSSFGKRHNKSHTLCRRCGRRSLHIQKHTCSSCGYPAAKVRGYNWGEKAKRRKTTGSGRMRYLKGVSRKFKNGFQAGAPTGARGPTKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQX2</accession>
    <name>A0A3D8QQX2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_10570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQX2"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="73"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW64068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="612" mass="69137" checksum="E77EF20DEFE1A184" modified="2019-01-16" version="1">MRDQEQFQMGRLKPPSHDGMQAAGTGSRPKYQYRLLTPGKNEIRLMKVLPAANSTDTIHCELLHTTLDEAPPYQALSYTWGDAAGARPICVDGMNLPVTQNLRHALHRLRPNVEPGLVLWVDAVCINQEDVSERGIQTGKMREIYRHAETVNVWLGLQNHDSGAAIELVDELNTCTPSEVGGIIQDPQRADQIKALVVLFRRQYYFRIWVVQEVQSARKAVVYCGPNVIPWIVLDKVCDILKREEIHLQKIFYKSPSFIRTLVSGGPRGLQLSRYSSTDLAPPLSELLLSHKSKKSTDPKDKVYALVGISSSRNSFGPIDYSLSVRDIYTHTARHIITTSQKLDIICVKQHDLDQFQLPSWAPDWTRPPPHPEHTVIGLHHSEEDFAAARETEAIFEFSDSGYQLKTKGIIIDTLKATSCAFKRTGSQSEAKPALKTLRQWWHIFSATKGDSLPSRAMFCQVISCGNWHTYDGDNYTNKLNAMFSLHNSLWSSEKNPIMSLLSNDEVTDTIVACSEEDYEKFQFATILSASLTMNRRRLFISSSGFVGLGPWNMEESDLVIVLYGCRFPVVLRPVENNYILIGEAYVHGFMTGEALDYLRDGLLHEETFEIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QR23</accession>
    <name>A0A3D8QR23_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_10446</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW63944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QR23"/>
    <dbReference type="OrthoDB" id="10027013at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051052">
        <property type="entry name" value="Diverse_substrate_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942">
        <property type="entry name" value="METHYLTRANSF_11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44942:SF4">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="52"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW63944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="291" mass="32916" checksum="C7E60DCBA9B34FF9" modified="2019-01-16" version="1">MAAMKFSLANPATTGFSDGSRYDKYRPSYSSEAVSKLLTHLNIASVARAKVVDLACGTGKFTECLAVRPEEFEIVGVEPHDGMREVLQAKQLGSHVKVLNGDAAHMPIENDWADVVIAAQAFHWFATEESLKEIHRVLVPGGAFGMIWNIEDYNAPKEWEATSKWEQKLKDIVNEHEDGHTRFRHLAWKQIFEQQLDTTPWQTLKDTFAHNMPNFSLPLGEETLKWTIWLTDEAVWDRYTTLSMIANTEGAERERIKKEVIEALKGADVERNAKGEVAVHGATYMAWTSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QR50</accession>
    <name>A0A3D8QR50_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Arsenical-resistance protein ACR3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_10650</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QR50"/>
    <dbReference type="OrthoDB" id="187348at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015104">
        <property type="term" value="F:antimonite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015297">
        <property type="term" value="F:antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015105">
        <property type="term" value="F:arsenite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046685">
        <property type="term" value="P:response to arsenic-containing substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1530.20:FF:000009">
        <property type="entry name" value="Arsenite transporter, ACR3 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004706">
        <property type="entry name" value="Arsenical-R_Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002657">
        <property type="entry name" value="BilAc:Na_symport/Acr3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00832">
        <property type="entry name" value="acr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057:SF1">
        <property type="entry name" value="ARSENICAL-RESISTANCE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43057">
        <property type="entry name" value="ARSENITE EFFLUX TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01758">
        <property type="entry name" value="SBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0059">Arsenical resistance</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="264"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="289"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="335"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW64148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="494" mass="54676" checksum="FB6A9BAED7649CA8" modified="2019-01-16" version="1">MSPVKILFRSDEQKFGMSLLNYDWPLASIFPTRSELKLSLKTERLYVSHSLYSTLYNFYQSFGFALNFLSFTWEPNITLIPISSTRGFNVLPFQMPTILPSEDVLPTPIKLDMNNQTPQDALVTRDIEKQAQDTSPRNGFQEPTESKASAFKSLGILDRFLALWIFLAMLIGILLGNFVKETGPALQKGKFVGVSIPIAIGLLVMMYPILCKVKYETLHRVFAKKEIWIQIGFSIVVNWIVAPFLMLGLSWAFLPDEQGLREGLILVGLARCIAMVLIWTGLAGGDSEYCAILVAVNSFLQMILYAPLAVLFISVISHADSTRAQVNYSTVAKSVAVFLGIPLGAAILTRFSIRKLTSGAWYDTTFLRFLAPWSLIGLLFTILVLFASQGAQVVHQIVSVIRVAAPLVVYFAIIFFATLAVTHRLGFGYKLAATQSFTAASNNFELAIAVAVATYGADSDQALASTVGPLIEVPVLLGLVYVVKWIGKRRDWKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUI0</accession>
    <name>A0A3D8QUI0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8 10">Polyadenylation factor subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_10151</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUI0"/>
    <dbReference type="OrthoDB" id="16717at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001039">
        <property type="entry name" value="Polyadenylation factor subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:002008">
        <property type="entry name" value="Polyadenylation factor subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045245">
        <property type="entry name" value="Pfs2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836:SF0">
        <property type="entry name" value="PRE-MRNA 3' END PROCESSING PROTEIN WDR33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="83"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="125"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="166"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="208"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="250"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="363"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="416"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="473"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="510"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="486"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="530"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU369034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW65459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="576" mass="63219" checksum="5A05C877B35D4115" modified="2019-01-16" version="1">MDSSVGTDTGEHDTNGEPIKGPVTDYSATMIHWMGRYRKPKYRPLVGERERPSPSYIVDMIPPILRPNNPADSIPARHLHSSLNKIKHPVNVVRWTPEGRRLLTASSSGEFTLWNGTGFNFETIMQAHDVAIRALSYSHSDDWLISADHDGIIKYWQPNFNNVKVIQGHTDPIRDLAFSPNDSKFVTASDDSTLKIFDFAGGVEESSLTGHGWDAKSVDWHRTKGLLVSGSKDHLVKLWDPRSGRCLTSLAGHKNTITKTLFEPLSGNCLATSARDQTVRIFDLRHMRDVLLLKGHEKDVSTIAWHPIHPGFLSTGGSDGALFHYLLDEPNTPPDQAHTIAPWDTSDPSNAPAQTIYPAHKLQYAHDFAIWSLDWHPLGHILASGSNDRVTRFWTRARPGEVDCFKDRYHLGEAAAEAQGTWDRRGNRKQRQEEEEQEMEDEMEGLVDQKMPARVPGLPGLPGIPGLPGLGGAPPPHLPGLGNAAVPPPPPPGFPPLDPSTLAELMRNAAMSGLPPPPPPGMAAFFPPGFAVPPPGAPPAPLSDSGSGSIRKRAPLPSQQESLEAIQRQGQFKRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QY63</accession>
    <name>A0A3D8QY63_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_09370</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QY63"/>
    <dbReference type="OrthoDB" id="3472919at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF12">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="156"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="66"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW66621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="226" mass="24101" checksum="43E4136005B7434F" modified="2019-01-16" version="1">MAEKISEEKKPGESEFSNASIFAPSLSATAMTPGELDPPTDSIRAENATDPNSNGRTLHGFRWFLVCFSLYFSCVIYGLDTTIAADVQAAVIVTFEDIGQLTWMGTGFPLGSLCAILPWSALYTRFDMKKLIIGGTILFEVGSALCGAAPTMDALVVGRVLAGFGGSGMYIGILNYLSMLTTTKERGGYMSGMGLAWGFGAILGPVIGGGFSISSATWRWSFYINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYG2</accession>
    <name>A0A3D8QYG2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_09591</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYG2"/>
    <dbReference type="OrthoDB" id="10429457at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="7"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW66842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="164" mass="17798" checksum="E4C463916FB07FCB" modified="2019-01-16" version="1">MGVVFGHCQKLSDNWDVTSPRLEACQGSSAVTISLFVCHMISDIVILVIPVLVIVSIWEVGLSVPRKLFIGAMLCSGIFTMVAAIIVFIMFLNVSDPASIANGARWARREQLIWVLLLSAPSIVSIFKGRILSKNTTTYGSMLGAEDKDEKSPRKGTSCIAELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QZ36</accession>
    <name>A0A3D8QZ36_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_09821</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW67072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QZ36"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF5">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="9"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="154"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW67072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="405" mass="45184" checksum="31A03D37B2C85C99" modified="2019-01-16" version="1">MSTSAQMNDVLIVGGGVAGLVLAQGLKHRGIPFRLFERDSHTLSKGYRFRVVDDGLDALKKTIRPSLWALFEATNPGTGQPNILLLDAVTGKKIKYAEIPKSRSVNFDRRWIRELLSIGIEEQIHFNKAFQKYDLLPSDEHNSGGVRVSFADGTTATGRTLVAADGANSKVRKQFLPDIRLLDVERSVLWGRTLLTPEFQERFNRPDIMAEYLSTIVDSQSPSHPCLFAPLKWPNNGKLSGLSPKLSDQSDYMFVTLSFETPSAKLDTEEARKQFALEITKTWDPQLKTMFSMMEDTAVLPIYSSRPDVKVWPTDERITLMGDSIHAMAPSGGSGGYTAVLDAAALTEVISQSWNGGDWVKLNDGICGYEKGMRERAKQSINVSFSNGKWLWAGKDWQEYAEIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R2T1</accession>
    <name>A0A3D8R2T1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09006</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R2T1"/>
    <dbReference type="OrthoDB" id="3524344at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="526"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="771"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="676"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="734"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="787"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="878"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="916"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="933"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="991"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1006"/>
            <end position="1022"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW68349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1092" mass="120363" checksum="3DE93D2E77A18BFF" modified="2019-01-16" version="1">MGQVRRTRANPSPGGFKSLPETTRQPTTRQPTTRSKKAPRIPGNGLRYTDRSPSPNDEEIAALADLDPYIPPEERKISSADVPGLHEQMRKAAKSKKTSQSIALSTEHEKPQATTTRATRNRINTRSQTRSASPPNEPTPQPTRKPARRARAQTNKRTRAQQSTIEETDPESDGHRPTKRARNVEAPTSRSDGADFAEEHHEPSPSLKNTPTAKGQGGRDTFHSTAQDNAESQSQDSITASTEHTVPGGFVQDDEAPVAKTPIARPQNEQQLFPRSADGRSRPAKTPLPKSRKMVSRTEPRNGKGRVEVRSAYPAGVNESQYNRYLADEWAQRHKRPVEELYRMPAKTMKCIFKVMLAEKASEPTRTFEEFLRATSEEPQPAANSMKELLLQATPQVTRVDEESEEEEYSRMLEQESPQPRYLTNGRNTHGSTKKASKEIVKPPAPGPSTTALVQSASTSVSIPPAHIIDKETLLTDPDVLEAAYIVSQAFAADQSRRSKPFPNAEYLGAFLDHYQQEDSAEFPAIAAPKRSSSPESQAIEAGETARFSSSPNKRPSVTPSKTPDANNSTMVPSTSPPENSVVSNISTESDTTPKVPQTQPHGSQSWLSSLTNTISSPLKLFSRGSRTAGNTPATKTPSANNLFAPSALGETSPTPTPRPASSKFGKNPTAGIKNAVKERNARAEQDLIDRSQVPIHLRDVMTSDQKAELKRAEDQETADRHAEERRKKRAAAQEEDVFRDESWEEEYVCEKGLLWVAKWVHEDGKRRKIVERRLKNPSWAVPDSSSSEDEDDSEEEVDSPSFSRAPVERTPIGQIQPPNARIFQQTRRAIGLPTPPSADEAEEPSEPERRSQSIEYDESFGDPHHARPYTGRLFGDNPNSTGKKQSRANLFTESREFKWGQPSESSGSAGFRPPSSGSDSSSSSDSSSGNDGFEKSADRGSADSRTEMLAREKQEAEAQTETEDPALRPSKWTQSPPPKPKPSNAMLPGKQTSENDPSSPSKPLYVDKFKPQKPSKLREVEQASPVPQKYNEFSIFALTAQQSLDLDGMELDSEVLNMIQSLNDDVFPDVGLGVNEFGIDGSVERAIARLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R2W6</accession>
    <name>A0A3D8R2W6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">ATP-dependent metallopeptidase Hfl</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BP5796_08918</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R2W6"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141164">
        <property type="term" value="P:mitochondrial protein quality control"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.760:FF:000002">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000175">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FTSH 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048438">
        <property type="entry name" value="Yme1-like_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076:SF97">
        <property type="entry name" value="ATP-DEPENDENT ZINC METALLOPROTEASE YME1L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23076">
        <property type="entry name" value="METALLOPROTEASE M41 FTSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21232">
        <property type="entry name" value="Yme1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="17">
        <location>
            <begin position="302"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="708"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDW68261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="749" mass="80658" checksum="2D925B0C9DCE2123" modified="2019-01-16" version="1">MALRTSAMSVLGRSHAILPRMTSAKTLQKAAFLGSSLAIRQERFSSSPTAWQAPSASHLRKYQSHTLSRMSMIQRRSVFGASTSRNLLAHMEETANKNPGSATAQNAFYQALLRANMPAIIVERYQTHQFASNPACEAVYQRALGMLGQAETNMSGGQYGTVQGNQYSTQMQAVGQAVAAASQGANVAVSRNGANSGTGGRDAPLHVVVEETIGGTIFKWVKLLLYFGLFTYLSMVVVAMLIEGFQSFRKVGGGKGDNEAKAEHQNVRFSDVHGCDEAKDELQELVDFLKNPDKFSTLGGKLPKGVLLVGPPGTGKTLLARAVAGEAGVPFFFMSGSEFDEVYVGVGAKRVRELFTAAKSKSPAIVFIDELDAIGGKRNARDAAYVKQTLNQLLTELDGFEQNSGVIILAATNFPELLDKALTRPGRFDRNVVVGLPDVRGRIAILKHHMRNIIADANVSVEALAQGTPGCSGAELENIINQAAVHASKAKAKAVSMLDFEWAKDKVIMGAEKRSMVISQKEKEMTAYHEAGHALVVMFSPRANRLHKITIMPRGQALGMTSHLPEMDKYSMSKDEYLTQIDVCLGGKVAEEIAYGPDKVTSGVASDLQHATQIAYAMVTRYGMSDALGNVDLGSNHDTLSTTTKELIESEVRRVIEEGRVRATNLIMAKRKELDLLAKALVDYETLDNEEAFKVVKGERLNKMIMPSGGMKLPEIGPGGSGSLPEIPSIPGSEPANQGKEPPKGGALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R394</accession>
    <name>A0A3D8R394_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Endoplasmic reticulum lectin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Protein OS-9 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_08941</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Peripheral membrane protein</topology>
            <orientation evidence="1 7">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the OS-9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R394"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045149">
        <property type="entry name" value="OS-9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012913">
        <property type="entry name" value="OS9-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414:SF0">
        <property type="entry name" value="ENDOPLASMIC RETICULUM LECTIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414">
        <property type="entry name" value="OS-9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07915">
        <property type="entry name" value="PRKCSH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0430">Lectin</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017737495" description="Endoplasmic reticulum lectin" evidence="9">
        <location>
            <begin position="18"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="10">
        <location>
            <begin position="149"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="178"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="444"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="450"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="477"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="513"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU369099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW68284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="532" mass="59149" checksum="891A3AAF54116E48" modified="2019-01-16" version="1">MRRLISAVLASASTALASQTVFSVHDDLLAFPQYEVAFSDSFISDTEASLIIDHALPSTQETHTSSTGIESPSNDQWPAGRSAGEHSFDPSTHMYELLRLANEQYLCTIPIVASPIKNETSEAEAKAAEQKELARATDRGWELLQELEGDCLYFVSGWWSYAFCYNAEVTQFHALPPSPGKPPVPQRDPNTKEFILGKAKSTTKERKQPEEDEWGHAIDVRRPKAAEPPITELQVKGDSRYLVQRMEDGTTCDLTGKPRKVEVQYHCNPHVTDRIGYIKEITTCTYLLVIYTPRLCSDVAFMPPKENKANQINCRRILPETEISEAKERKELEAKLAATKSSEEPPIVIGGVLLGGGKFHSSEGQRMPVPRDFADFNSGKTIEVIAKGKSKADGGKVESATDEELQKLDLDPEMVEEVKKQVSKMAKEKGWKIEVVDAPGQVREILGIVDPDDTDEDDTNDAEQLGGENVRQPVLKGTEKAKPEKAKPSYETDGKKDIKEEKVAEDRVPETLPEGEQEESEEGSEEIYKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R3H2</accession>
    <name>A0A3D8R3H2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">1-alkyl-2-acetylglycerophosphocholine esterase</fullName>
            <ecNumber evidence="1">3.1.1.47</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_09252</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.47" evidence="1"/>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R3H2"/>
    <dbReference type="OrthoDB" id="2363873at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003847">
        <property type="term" value="F:1-alkyl-2-acetylglycerophosphocholine esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272:SF14">
        <property type="entry name" value="PAF ACETYLHYDROLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10272">
        <property type="entry name" value="PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03403">
        <property type="entry name" value="PAF-AH_p_II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017726145" description="1-alkyl-2-acetylglycerophosphocholine esterase" evidence="5">
        <location>
            <begin position="24"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW68595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="384" mass="41338" checksum="64347EA67F302432" modified="2019-01-16" version="1">MLSPTVSLAGLLVLASIFDTVKSASFPAPSGPYNTTLSTVQLIDKHRRDPFSPNGTARTIMISVFNPLSPELCTPLTVPYMDTLTAAYQDIKFSDYGLPAGTFESLELQVCQPKPAKETCPKSSSEKGPKHPLVLFSPALGTTRLFYSAMAQQVASAGYTVVTIDHPYDVDIVTFPDNTTILESNITTDNDVLLALDTRVKDITFVLNQLSLPSVAKRLATNVDISKVGIFGHSLGGAAAGEAIFYDRRLQSGINLDGSFFGTITEQGLSKPILLFAHEGKNTTTDPSWEAVWSRLRGWKRELMLAESAHYTFSDLPDVVRVLGIAGGLPDEVAGLLGTIDGGRALVVVTAYVEAFFNYFLRGDENTLLNGSSAAFPEVTFVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R3N9</accession>
    <name>A0A3D8R3N9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_09322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R3N9"/>
    <dbReference type="OrthoDB" id="3553625at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW68665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="269" mass="29031" checksum="81633CC26FA6B9FC" modified="2019-01-16" version="1">MIVTKIVSQSEIAKDTTIGATGGAAVDVHVIAENFNASETHVLIGYPPHLHSLTNIPIRIRSWRIVVWVSRLIGVVLAVQAAALASQFGADGKQVVGSGVWLIAYAVLLISSRVVTSRCPDALLRHQPTTADQLSHIGISSRRAALAFIATLPVSQKSGRWEWMNGFVPADERRKHWENEMAQGGLGEDRVLEDDTSISASSRGVLEEVRKARSSMEFVEASAKFYAAIGLTKRNPSPEQVVPGVVTTDSVDSEARPQESGVPSHPKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R3S3</accession>
    <name>A0A3D8R3S3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_09334</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R3S3"/>
    <dbReference type="OrthoDB" id="4951845at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054416">
        <property type="entry name" value="GST_UstS-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22041">
        <property type="entry name" value="GST_C_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13409">
        <property type="entry name" value="GST_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="18"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Glutathione S-transferase UstS-like C-terminal" evidence="2">
        <location>
            <begin position="115"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW68677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="241" mass="27418" checksum="F5585F534136CAFE" modified="2019-01-16" version="1">MPTAILYDIPSRGPCACWSPNPWKTRLLLNYKNIDYKTEWVEYPDIAAKYKELGIPPNPKEPYPYAIPGISIETSDGLLHLQGSREIATVIEEYWPTPSVHLDSPYMEKIDTFKFVGPLATLLMPRNAQNILSPVSVEYFSRTRSARFGMTLDEFENSKPVDEVWANATKVLSELADMLKENPSGPFLMGKEVSYADFIVVGVFQFYKRAGQDIFDRAMAVDTALHALYDACEPWLKRDNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R773</accession>
    <name>A0A3D8R773_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_08302</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW69905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R773"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07106">
        <property type="entry name" value="ALDH_AldA-AAD23400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000032">
        <property type="entry name" value="Probable aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044086">
        <property type="entry name" value="LUC3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="37"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW69905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="492" mass="54013" checksum="6FD086A7DA720EFA" modified="2019-01-16" version="1">MDLSGSPESQGFEEVRAARPGPSRPGAANISIDFTTRHTLNPATGQPLGEVPVSTQEDVNTAVQHARQAFKTWSKTTYAERGKLLAAYADAIEHHLEDLQNLLVQEQGKPLGLAGIEFGVTLRWLRAFATMEVKEEILDENDERTIYQTFPPLGVCGGIVPWNWPILLGLGKVAPALLTSNTMILKPSPFTPYCGLKLGEIAMSIFPPGVFQVLSGGDDLGPMFTEHPDIDKIAFTGSIETGKKVMMSCAKTLKRVTLELGGNDPAIICEDVDIAKIVPKIATMAFMNSGQICMLIKRLYIHEKIYDEFRDAMVAFTKTIKTGNGFEPDVMVGPLQNSMQYEKVKDLYAEIGKCSWKTAFGGEIQEAAQGYFITPAIIDNPPDDSRIVTEEPFGPIVPLLKWRDESDVLERANSGKTGLGASVWSRDLARAERMARQVSAGSVWVNSHFDVAPNVPFGGHKWSGIGSEWGQTGLKAYCNSTSLWLWKKVFED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7N5</accession>
    <name>A0A3D8R7N5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7N5"/>
    <dbReference type="OrthoDB" id="526941at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW70062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="368" mass="40940" checksum="D29A3BEF77CF1DEB" modified="2019-01-16" version="1">MTIKSTTKSPYGAALVVLLVIWSLWYMDLSSVRGAIQRHNSETGRTGQSTAIGFGDASEAKSSPVDGSVQPVLSTTAAAKIERPLILYAYSETTSARTNLEFFIRHGLHAAADFIFILNGATDATTLIPLADNIRYVQRANDCYDLGAFAEVLTHDDLYKNYKKFIMLNASIRGPFLPYWAESCWSDMYLKKVTDKVKLVGMTGNCWPVFHVQSMIWATDIVGLEVLLNPTKEQISAAEKYRPKSTEKRQFDADPNSSSRLAPGINHCFHTWSNAVNAEIDASQLVKAAGYGVDVMMSAYHKNEHYEDECDSSANGDVLWEGKYEGTNVHPFETIFLKSNRDIDPVGMAKLTEWTDGRAYSSYNFCKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7Y4</accession>
    <name>A0A3D8R7Y4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_08473</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7Y4"/>
    <dbReference type="OrthoDB" id="331544at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008460">
        <property type="term" value="F:dTDP-glucose 4,6-dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05246">
        <property type="entry name" value="dTDP_GD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000304">
        <property type="entry name" value="UDP-glucose 4,6-dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005888">
        <property type="entry name" value="dTDP_Gluc_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43000">
        <property type="entry name" value="DTDP-D-GLUCOSE 4,6-DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="4">
        <location>
            <begin position="53"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW70076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="436" mass="48645" checksum="4C348843F669188E" modified="2019-01-16" version="1">MSGKHPSGGPPTPAASTNGEHNKFFEDFGVWKDAPVLIGSTKFTPSTEVKNIMITGGAGFIACWFVRHLTLQYPDAYNIVSFDKLDYCASLNNTRILNDKRNFSFYHGDITNPSEVMDCLQRHNIDTIFHFAAQSHVDLSFGNSYAFTHTNVYGTHVLLESAKKVGIKKFIHISTDEVYGEVKDDADDLLETSILAPTNPYAASKAAAEMLVHSYQKSFKLPVIIVRSNNVYGPHQFPEKIIPKFSCLLNRGKPVVLHGDGTPTRRYLYAGDAADAFDTILHKGTMGQIYNVGSYDEISNLTLCSKLLTYLEIPHATQAELHKWVKHTHDRPFNDHRYAVDGTKLRQLGWDQKTSFSEGMAITVDWYKRFGEQWWGDISKVLTPFPTVAGSEVVADTAAPVEDVKEDMIVDRDENMTLAKKRKLNEGTSAATAVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCM1</accession>
    <name>A0A3D8RCM1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_07833</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RCM1"/>
    <dbReference type="OrthoDB" id="408702at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF131">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="2"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW71799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="292" mass="33925" checksum="78D332DE599732E1" modified="2019-01-16" version="1">MDLRRKIEVGLILSLGSFGCVVSMVRLKALRTAHFGVSTDTTHDYILPVIWTALELAVAMSCACLPAIRNLWLRMCSRKKASIVSVPTPGTSGSSNPKPRIKPYAGVSTIMDDDNSTLITQPAPSYELDQYVNQPHRHEPEQRVNQPHRHELEQRVNQPHRRELEQRVNQAHRHELDQYVNQRYRHELEQRVHQPHRHELEQRVHQPHRHELEQRVNQPHRHELDQYVNQRHRHDEHGATTQTYTGPSQMTWYRAEEGEVGEIEGNWPIASSPRKSAFSKGESEIHIFPGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCQ3</accession>
    <name>A0A3D8RCQ3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_07732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RCQ3"/>
    <dbReference type="OrthoDB" id="5366332at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW71698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="340" mass="38453" checksum="787C0816C2F549D0" modified="2019-01-16" version="1">MAPQDPKRLSALNTHWHNRSQSSSNSDAGTFHSAIASHTQGRRSQTPTTAIELQPHKPARESRLESIKMDRSDSGFEDGVQHKRRSSNFSQASPRHSTSSRHASPRPSLSTPRPQQQQQLQQHQQQQSQQPSQSKRRSQHRTTPSSSSVATPPRRSTSSWRAGAPRPSLHARHTTPYIRTSATSNPNTASPTASYPQAYFQFPPIALTQTPQNNDELPSENDRAREREIQNRSPPPTTIQYWTSDSTRRLEYAAIDAASKGVRGFVRKMIPDCFLPSSTKARRFHDGDDDDVGSVRRYRLDLPEEEEESSCAKEAREPKTKEARPIFRRWTTFGARRKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCQ9</accession>
    <name>A0A3D8RCQ9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_07794</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RCQ9"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009688">
        <property type="term" value="P:abscisic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF12">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14340)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW71760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="267" mass="28989" checksum="0F3F4F591C285196" modified="2019-01-16" version="1">MPEFPPDSVAFVTGAGSGLGLHVAKQYLTDGILKIAIIDISNERLLETEKLLLNLSAYAKVLVIPTDCSKEAEIEAAVAKTVEEFGRIDVCFNAAGIGGAPGPSTEQKTEDMLYLMQLNVMGTWWCNRAQIRQMLKQEWRDLTTGLPFKTRGSIINVGSLLSHRAIKYGGTYAMSKHSVIGITRQDAVDYGTEGIRVNAVCPGAVRTNIFTPDVWESPLGVQLKERSALNRHGLPEEVAYLVGFLSSDKASFITGAVYNIDGGYTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RD30</accession>
    <name>A0A3D8RD30_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Metalloendopeptidase</fullName>
            <ecNumber evidence="2">3.4.24.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_07835</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="1 2">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="1">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.-" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RD30"/>
    <dbReference type="OrthoDB" id="3455903at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001506">
        <property type="entry name" value="Peptidase_M12A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006026">
        <property type="entry name" value="Peptidase_Metallo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127">
        <property type="entry name" value="DISCOIDIN, CUB, EGF, LAMININ , AND ZINC METALLOPROTEASE DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10127:SF893">
        <property type="entry name" value="METALLOENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01400">
        <property type="entry name" value="Astacin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00480">
        <property type="entry name" value="ASTACIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00235">
        <property type="entry name" value="ZnMc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51864">
        <property type="entry name" value="ASTACIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1 2" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 2" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017498160" description="Metalloendopeptidase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M12A" evidence="3">
        <location>
            <begin position="19"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="141"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW71801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="391" mass="43787" checksum="DCBEF34580C50C49" modified="2019-01-16" version="1">MLYNTKLAAVAMSLLASQQVIAKPIESRGSMWEYNHWPNAEIPYILTGLPHDLSENIRGAMRMWEAQTCIRFVPYTNQPAWAEFRKWDQGCFSQQMGAPSSGATIVNLDSPNFWDRLTFSKVCNTPGTAGHELGHLIGLAHEQQRPDRDQYVRVLTNRIDPNFLDQFDILPWIDTSLPFDYNSSKRAVPQRSQVSILIPMTVMMYSNTAFSKKGKPTIESLTNQEINPFDYATQGDYAAVNKAYNCPAWLTNPIPECRKGAIPANTDFSSYDFIVDDTTLNQAKAGGYTHFAVHQHCNSNAPNMDTDNWGFTPVAGSGPNARYKVTTDRCKKTHDRHAAKYEIALCRGDWTEACDMMCGYRSVCPTAADGTDQESKAVDLVDDAAWVCHAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDS1</accession>
    <name>A0A3D8RDS1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_08247</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDS1"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW72213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="147" mass="16338" checksum="9FB5EFB000D3202B" modified="2019-01-16" version="1">MERAINWQITGSAFTPRCYADAKACLPPVDAAIALLDPFCRRCASCAWRAVQIPGWEWVAIEAQHHRVGPRCSLYMTQIRFTGLCVLRTSSTIFHDVVVALAQIAEAGASAQRLLTMHRSVKGISIGIPQQQCPEQRASNPWFWATL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDU1</accession>
    <name>A0A3D8RDU1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Aldehyde dehydrogenase-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_08243</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDU1"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006598">
        <property type="term" value="P:polyamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000001">
        <property type="entry name" value="Aldehyde dehydrogenase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000026">
        <property type="entry name" value="Aldehyde dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720:SF3">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE ALDH (AFU_ORTHOLOGUE AFUA_8G02310)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="28"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="active site" evidence="3">
        <location>
            <position position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW72209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="501" mass="54068" checksum="E8CA5D765FB69CBA" modified="2019-01-16" version="1">MASLFVELKAPNGRTYTQPTGLFINNEFVAAKSGQKITSIDPATEAEIASVHAAGAEDVDLAVQAARRALKDPSWKKMSPTDRGNLMIKLSDLMEQNKELLATIDTWDNGKPYSAALADDLPEAIGTIRFYGGYADKVYGQTISTTHAKFAYTVRQPIGVVGQIIPWNYPLSMAAWKLGPALACGNTVVIKAAEQTPLSILVLGTLIKDAGFPPGVVNILNGYGKDAGKAIASHPDIDKVAFTGSTGTAREIMKMAAVNLKNITLETGGKSPLLVFDDADLEQAVKWSHYGIMSNQGQICTATSRILVQETIYETFVKQFKDALSSISKVGDPFAEDTFQGPQVTKAQYERILSYAKIGVAEGATLAAGGKPFNGPVGKGFYIEPTIFTDVRKEMAIYREEVFGPFVVILPFKTEEEAIEMANDSQFGLGAAVFTTNLERSHRVARDIESGMVWVNSSQDCDFRVPFGGVKQSGIGRELGEAGLEAYSQIKAVHINMGSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RE88</accession>
    <name>A0A3D8RE88_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Clavaminate synthase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_08208</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RE88"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="158"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW72174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="325" mass="36735" checksum="66C5CA65B994CA90" modified="2019-01-16" version="1">MTESNFPILSFQEFLSGSEEQKRVVAQKLYNAFHNFGWVYLKDFGITQQEIDEMFSMSKRYFERPLEAKLKETLKDAEVNQGYTPDGAEANGGTDHKECYEHRRFCNDLSPSDEELKGFKTFLDDFYERCFNLAVSVLQALALVMDLDINYFSTALAKADPQLRLLHYMPIQRSVIEAEGHARIIPHTDFGLCTLLFQESGGLEVDPFHTGNFLPATPIPGTCVINVADLLQRLSNDRLRSTLHRVTTPPLSKEALEKIGEHGLLPARYSTAFFVHPSADIDIDPIARDGEVKKYPKVNAGEWRVMNTAKNYSSILGSEGTQIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RI24</accession>
    <name>A0A3D8RI24_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_07062</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">In the C-terminal section; belongs to the aldose epimerase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">In the N-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RI24"/>
    <dbReference type="OrthoDB" id="9402762at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF47">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0299">Galactose metabolism</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="11">
        <location>
            <begin position="21"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="11">
        <location>
            <begin position="146"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00038238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW73620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="559" mass="61040" checksum="3879107512022CCE" modified="2019-01-16" version="1">MPATISTLKAARDATKGFPIVLVTGGSGYIGSHTVLGILKSGCAVVVVDSLINSHMEALIRVYHIAKTEMAKVGKSPESLPPLFLHTIDLCDKKRIFNVIQFWQTHDHPTELLKKLDLVDIGQLAANKAYNMREYPQNETWHPESLNDESFKSLLSSRGQIVAVIHFAALKAVGESVEQPLRYYQNNVTGLLYLLDAMTRFKVNRIVFSSSAVVYGSGKGANIKEDAVQVGGQGAGGGFVTNPYGRSKWMAEEILNDCCVANSDFQVISLRYFNPTGSHPSGLIGEDPKGKPNNIVPVILQAYQRRRSKVHVFGSDYDTTDGTGVRDYIHVEDLGRGHIAALRSLLDPRDSGRTRTSFQPDGAEPEILQNYRVYNLGSGNGYSVLEIIQAFASVASAEIPYSIGESRPGDLGTVTASTTKALSELGWQANFGIQDMCRDVHAFATENPMGYERLRRLSTLALKDPEAFHKASEEIGVAQVNLEEMMTGVARLASHENAFTDVVRRLSVLSDGIKSELRKESISDIGPPATALDTSAPSWAMFGDDWHKNVPARPAESTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIF1</accession>
    <name>A0A3D8RIF1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative NADH2 dehydrogenase chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_07267</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIF1"/>
    <dbReference type="OrthoDB" id="1913277at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045271">
        <property type="term" value="C:respiratory chain complex I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039205">
        <property type="entry name" value="NDUFA11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21382:SF1">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 ALPHA SUBCOMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21382">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW73825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="191" mass="20562" checksum="2A16FFD4A21C8664" modified="2019-01-16" version="1">MASGDHHYHPKDAVKACLNGAMVSGSAGAMVSAIQNTLTKRNVNAWGVFTRTGGTIAVFTAMGATYEFSRNAAANLRQKDDSLNTGIGGFLAGSVLGLRVGRTPAVVGYGFLCAVVLGTFDFTGGRLTGYLKDSEVDEFERKQELRKNRRRPIQETIDELGEGRGIYAPGYPERRAAIIKEKYGIEVPARS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIH9</accession>
    <name>A0A3D8RIH9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_07093</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIH9"/>
    <dbReference type="OrthoDB" id="6499973at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF130">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="180"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="288"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="355"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="415"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="447"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW73651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="52160" checksum="5DE0F3707DE338F6" modified="2019-01-16" version="1">MANAKLDFEKEVDVSSDSSEHHDDDIEHEDTESPRFMPMIAGASSAEKDVEAQSSKKENSVKALKNVLTRTSTKSSWIDPGPPPDGGWRGWLQAALGHLVIMNTWGFINSYGVFQTYYVQMLDRPQSDISWVGSVQVFLLFFIGTFTGRLTDAGYFHLVFALGTLLYAIGIFMVSLSTAYWQVFLAQGVCMGLGMGCLFCPALSILSTYFSTKRSLAIGIAAAGSGTGGMVFPAMVQQLLPKVGFPWTIRAVGFIQLTALVACNIGIRPRTLPRKTGALVDWQSFKEMPYVLFAVGMFFNFCGVYGPFYFLGTYARQNLSVSYTESINLLITMNGVGIVGRILPNHLADKHYGPLNTLIPSVLASSVIIYAWIGVHSRGGLYAWAVVYGIFGAAIQSLFPATLASLTSDLRKAGVRMGMVFTIVSFAVLTGPPIVGQLIQVNHGDFLYAQIFGGCVLLVGCCLLVAARMAKSRELWVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJ47</accession>
    <name>A0A3D8RJ47_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="11">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BP5796_07515</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="11"/>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001975">
        <property type="entry name" value="ATP-dependent DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000296">
        <property type="entry name" value="ATP-dependent DNA helicase RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018982">
        <property type="entry name" value="RQC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09382">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00956">
        <property type="entry name" value="RQC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="883"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="1091"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="28"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="324"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="418"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="459"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="636"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="679"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="814"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1400"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1488"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1684"/>
            <end position="1782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="31"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="147"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="252"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="418"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="459"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="636"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="655"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="720"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="819"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1406"/>
            <end position="1424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="1702"/>
            <end position="1714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1740"/>
            <end position="1754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1755"/>
            <end position="1764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDW74073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1782" mass="199042" checksum="9799EC8CA9970826" modified="2019-01-16" version="1">MTRHNLQVHISWLLRNKVTPPVGVTANFDPENFDEDFAEDSIDEDNSPPLPSSSDSSRIPQIIGVVAEEEFVRPTLPRTKPSKPLPAELPQRSGIDGSMGRLESTRKSARPGLMSQQQHQLATPASTSGSTAKSLHQNYSAFLRGNATPSTKLSSEQFPTSASKPLPRPQTPRQTPRRPSCQPSELKSQPVESIDLTEDDYTRRPSSRSSSSVEIWGEPTTLWTEDHASRLGPLSKHGKKRKSIEIDTSDSPSKDKSRSPEKIKRKRRPPSDDFEDIDELEISETLLASAAKSVPVPACKVGFENLSEEEYSITETISRMESRIRRSASRDTSDIATDTTRRSRDVHSDMRLNRSQSFLQVNATPNCLPPPIVATTETPQKQRDASTKTRVIQDSEDDEAITFEDFGASYSPDYAIKNSSQLRSPQKAANWQSMRDCELSRRPSTGLEESAQRLGSPLASISSNLGQKGQFSTPFESKSPRKLANVFPEIDLNSSQQVSSSLSADHELVKTYLKDTLALKPYQQRLRQRLNQNSVESMAYHDNNERAPANLMEERKTMLDMNHAFSSLEIELNKHKTVTEEKRQLARKMFDGLDEDGDAERAAQKARDLRKIEATIGVLLRVSGVVEEGFGSNSHALANLDSVSSPKNDQDALGRSTTDSSVPASNQIILQTQIPALRQSSDIEKSRRVQGFMQPQSPTHTDLLRLSGANSPPSRRDNNADLTSPTRSNQSTARPKPVTAATRQPDLFRGPSPLPYDVDDNYFEDMLEDELEIQSGTARILGTMAFEEEEDYGGFDDDDDEVLEFFERQQQSFDDFSSHRTTLSNSSSKPSKRRSTTSSKDMYAHVDNAHANQWNHPWSGDVKQALKDRFKLSGFRNNQLDAINNTLAGKNTFVLMPTGGGKSLCYQLPAVVQTGKTKGVTIVISPLLSLMSDQVQHLQKLRIQAAFLNGDSEQSQRIELFNVLKGPYPEQYVQLIYITPEMIGKSQAFISALSILHSKQKLARVVIDEAHCVSQWGHDFRPDYVGLREVLVKFPGVPIMALTATATKNVQADVTANLGIEGAEVYAQSFNRPNLNYEVRAKKEIGTSKEILADMCRIIKEKHKNQTGIIYTLSRKGCEDLAATLRKDFGINAHHYHAKMDKEQRLQVQQKWQSGEWKVIVATIAFGMGIDKADVRFVIHHTIPKSLEGYYQETGRAGRDGRPSGCYLYYGYGDTAILQQFIDKSDGDHEQKARQREMLGRMIQYCWNRIECRRTQILAYFGETFTKEECNHTCDNCKSDTQRVEVDFTAEARAAVSLVGHLENAKVTMLHCVKILQGDSKERKIKDLNHNSLKEFGAASKLNRSQIERIFHRLVAENLLYEENLMSNHRPKGKPAFVTKYIKLGPNYRPLMNGQRRLRLHELKSTEPTTKTSTSRTKAKATSSKSKKASDATASHISSTYPSTIVTSPVSGPDRWRNRSFNEANFTDAPRSNRGYRPDSFVISSDIEGSQSDDAFDPPVHGRSSHRRNGATARLGPPITTDLRMDALQHDHQVIVHQFVEAAKKLEEKIRNQKNLRRPLFTEAHLRDMAINWTLTPDEMCRISGINKEHAINFGGRFVPLVREYHQNYETLIEDEKQDRDMDANHNIVDPVTEEYGEYDDSFDPQDDMDDAVVEPSKYFSSKPKGPSAAELARFNQVMSIASATPSAQPRAMSPTPARRSYGGGNNSGKGKPSGGKKTRLRKGSGQSSAGITKRKSFGSGTNNSKKPNTTNSSRSIMAQFANNSGSRRGGSGMSGIQPMPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJA4</accession>
    <name>A0A3D8RJA4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_07571</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DAMOX/DASOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJA4"/>
    <dbReference type="OrthoDB" id="2015447at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003884">
        <property type="term" value="F:D-amino-acid oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019478">
        <property type="term" value="P:D-amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023209">
        <property type="entry name" value="DAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530">
        <property type="entry name" value="D-AMINO ACID OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11530:SF16">
        <property type="entry name" value="D-AMINO ACID OXIDASE (AFU_ORTHOLOGUE AFUA_5G11290)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000189">
        <property type="entry name" value="D-aa_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="7">
        <location>
            <begin position="8"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="48"/>
            <end position="49"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>D-dopa</name>
            <dbReference type="ChEBI" id="CHEBI:149689"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000189-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW74129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="295" mass="33038" checksum="7ACECB2D4FDC071D" modified="2019-01-16" version="1">MDAPEIFVILGAGVIGLTTALELAARYQHAAIHVAAKFLPGETSIEYTSPWAGANFSPVAKNAREENWDTVTYRRFTRLAEDAPESGVQKMELRALFDMPIEESGIFSPEQGKIWYEELVGGFRGIANEDLPEGAVWGHDWDSFIVNVPVYLSWLRNEAEKIGVHFHRRFFEGLDELYAAFPQARAFFNCTGLGSISLKGGQVMLIESPMMQLTRSYERANKDESILTYVYPRNPAGGVIIGGCRLDHNWEEEADLQAAEAIKRRCCELAPELGQPGDLKVLQHIVGLRRKNCNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJC0</accession>
    <name>A0A3D8RJC0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_07383</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJC0"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06609">
        <property type="entry name" value="STKc_MST3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000488">
        <property type="entry name" value="Related to severin kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="260"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="446"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="330"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="413"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="447"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="511"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="542"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW73941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="672" mass="74172" checksum="50828C2860ABE676" modified="2019-01-16" version="1">MSSGGGGMMSGVVDPDTLYTKQNCIGGGSFGKVYKGVDKRTGQSVAIKVIDVENAEDEVEDIIQEISILSELHSPYVTQYHGSFLKGSDLWIVMEFCSGGSCGDLMKPAANVLLGANGQVKLADFGVSGQLSATMTKKNTFVGTPFWMAPEVIKQSGYDHKADIWSLGITALELANGEPPYSDIHPMKVLFLIPKNPPPRLDGNFTKAFKEFVELCLQRDPRERPSARELLRHPFVRRAKKTSYLTELIERYERWAIHHKSDDDESDDGQEEAQPRTAANDDLWDFGTVRPVGGKAAGRAGLNTMGESATNARSSRSSESEDDYAERPRQQSPSKMSPTRTRHEEYGSTNETVKAANSPVASQPRQGSPQRRPPPIMQPLSPAKVPLPPSPEKTRGQGPETPRASQQNFVPRDSTESPDYDRSLQEQLHKDMGFLKLANDNVSLENPFLAQAQPQFQAPQPTQPRPILQQPLPKLGPIKLPEIPPFRGQQPLQKVTNHSIPPLPKEHGNAPSMQPLSSQTVDPRQVAQQPLPALPSKLLRNSPSRESISSNSSQTPTAMPDRAPSGSDGELDALNDVIFPALEEALKRRQFRLQQACRAAGPTPKQQRAQAAHEKLRKLVFKLAHVCKEIDHWDKQEPVGMGKDVDVFLEGLLEEILVRVEPADEEEGEYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJJ4</accession>
    <name>A0A3D8RJJ4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_07550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJJ4"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW74108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="32818" checksum="5C3FA6CAA83BA54B" modified="2019-01-16" version="1">MSSQQKVALITGGASGMGLAVAQKLSNLGNWSIHIIDLNEKTGKEAMESVPRSMFHQCDVTSYAALGNVFKAVFQEFNRLDFVFANAGIHEMGTTGDFFAKHTTGLEPPAEPTAKHRVVEVCLNSVINTSYLALHYFRQNPDHRNIDCNLIITASCGSFYHSSNAPVYTAAKHGIVGFMRSIAAKMYAHDRIRVNAICPGAVITGLFTQKQWDAFPEHLRIPLSHVVEVVSMLLEGKLKDGVDEAQLRIDGPKKEKENEPLWGEAVEITPSRYYFREAPKFSDDSMRENMEAANPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPG0</accession>
    <name>A0A3D8RPG0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arylsulfatase</fullName>
            <shortName evidence="5">AS</shortName>
            <ecNumber evidence="5">3.1.6.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Aryl-sulfate sulphohydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_06716</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an aryl sulfate + H2O = a phenol + sulfate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17261"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16189"/>
            <dbReference type="ChEBI" id="CHEBI:33853"/>
            <dbReference type="ChEBI" id="CHEBI:140317"/>
            <dbReference type="EC" id="3.1.6.1"/>
        </reaction>
    </comment>
    <comment type="PTM">
        <text evidence="6">The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.6.1" evidence="5"/>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPG0"/>
    <dbReference type="OrthoDB" id="96314at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005539">
        <property type="term" value="F:glycosaminoglycan binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008449">
        <property type="term" value="F:N-acetylglucosamine-6-sulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018958">
        <property type="term" value="P:phenol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16147">
        <property type="entry name" value="G6S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000051">
        <property type="entry name" value="Arylsulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012083">
        <property type="entry name" value="Arylsulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-SULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43108:SF8">
        <property type="entry name" value="SD21168P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000972">
        <property type="entry name" value="Arylsulf_plant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017693314" description="Arylsulfatase" evidence="7">
        <location>
            <begin position="17"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="domain" description="Sulfatase N-terminal" evidence="8">
        <location>
            <begin position="30"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="modified residue" description="3-oxoalanine (Cys)" evidence="6">
        <location>
            <position position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR000972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000972-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW75895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="593" mass="66598" checksum="F3BE5C42F33BF575" modified="2019-01-16" version="1">MQLFGTALALAALTSAVDHQHALKHGDSRPNIIVILTDDQDLHMQSVEYMPLLKKHMIDQGTYYKKHYCTTAICCPSRVTLWTGKNAHNTNVTDVHPPYGGFPKFVSEGLNKNYLPVWLQEAGYSTFYTGKLFNAHNVQNWNSPHPAGWTSSDFLLDPFTYEYLNATFQRNQDEPVSHEGEYSTDVLAQKAFGLLDEAVNSGKPFFLTMAPIAPHSNVAAQQSPEPRSTPFTPAELMAVKMTTPIPAQRHKELFPGAKVPRTANFNPDKPSGVSWLKHLNQLSAEVIEYNDDYYRARLQALQAVDEMVDELFERLASRGLLENTYVIYTSDNGFHISQHRLAPGKECGFEEDINIPLIIRGPGIPVGEETDIVTAHTDIVPTIFELAGIKPREDFDGSAIPLNTKGLQQAIGERQEHVNVEYWGNAIAEGNYWFSLDDGKPVFYGYNNTYKALRLIGKDYNLFYSVWCTNEHELYDMVTDPYQINNIYPSAPTEPERALLNIPLSKVLPRLDALLMVTKSCKGVTCVNPWSVLHPQGEVKSLGDALNTKFDAFYMLDVKEKVSFDKCELGYIVESEGPQARGLPVFGQHKEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RQ59</accession>
    <name>A0A3D8RQ59_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">LicD/FKTN/FKRP nucleotidyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_06956</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RQ59"/>
    <dbReference type="OrthoDB" id="444255at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009100">
        <property type="term" value="P:glycoprotein metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009644">
        <property type="entry name" value="FKTN/MNN4/W02B3.4-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007074">
        <property type="entry name" value="LicD/FKTN/FKRP_NTP_transf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407">
        <property type="entry name" value="FUKUTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15407:SF32">
        <property type="entry name" value="PROTEIN (MNN4), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G03790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04991">
        <property type="entry name" value="LicD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017736613" description="LicD/FKTN/FKRP nucleotidyltransferase domain-containing protein" evidence="5">
        <location>
            <begin position="19"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="6">
        <location>
            <begin position="93"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="domain" description="LicD/FKTN/FKRP nucleotidyltransferase" evidence="6">
        <location>
            <begin position="201"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW76135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="279" mass="32731" checksum="EB4B64A8FF38B0E2" modified="2019-01-16" version="1">MRVAWLLALPAVLSVTSAAVLHRRNADFYSVRTKMHQDLSGRLGDPKEKYFHESVFHPHYDGRFASEQLPYTERKQALSNLIQTYLATFADIGVETWLMHGTLLGWWWNRKILPWDSDSDVQVSEESMKYLASYYNMTIFHYKTPRIPEGRDYMLEINPHYINREQTDNLNVIDARWIDTDSGLFIDITTARYNYTHPAGKGILSCKDGHEYRDTYVFPLRDTFFEGVPAKIPYAYKEILEAEYQSKALIQTEFEGHRFDQEKSEWIPVLKKAKPYVPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RUX6</accession>
    <name>A0A3D8RUX6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_05705</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW77853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3990906at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17327">
        <property type="entry name" value="MFS_FEN2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000018">
        <property type="entry name" value="MFS transporter permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF101">
        <property type="entry name" value="HIGH-AFFINITY NICOTINIC ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="430"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="45"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="645"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="553"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="731"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="553"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="748"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="770"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW77853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1351" mass="150811" checksum="FFE4A50FAA4E2D17" modified="2019-01-16" version="1">MGSPETVGNAPEMQAPFDKAESLDMDLYIDPVKERKMMLKFDVCAIGMLGLFYMMANLDRGNLGNANIAGMSKEIGLVGNQFGTAVTLLYATYVTVELPTAILLKIIGPRYLLAGCAFCWGVTTLGMGFIQNVAGLYTCRLLIGFFEAAIFPCIDVYIGMVYKKEERGTRSAVIFAFSSFSSAFGGLLAFGITQINGPNGFSGWRWLFIVEGVITLFIVPLYWFLFPNDARTAWFLTAEEKRMVHARYELDPHWGIDDEFSWGAITSVLIDPKFYAFFIFQFCCDVSLYAIQTFLPAIVKGLGYTSVTANLMTVPVYMLGLFWFLFVAYMSDRTKLRGVWIAGPLLLLIIGLAILIGVDKTSIRFFGCFVTILGIYPTVGLSIMWMSDNVGRHFKRASMVGMVLTIANTAGVVVGQIYRTEDSPRYIKGLEISLGLNVVAFVMVMALMGGMWWVNRKRAAAIQKGLAEGNPVPAQPEKGDYDPHFSCKNIEQGESITRPVLHEDYLASSRVAELFHAMHQEDALGSFWEDILPDCGSSRPPPLLESLETTKRNLHSDQRDQKRAHPQTDLRNVGRARDPYRRHPHSRQLRPIQTFNNLPSKHQLHSALFQRCQCMMEQSRSPSTSYSVEDDSQRRVRHIRRGGVACKRCHKNKTKCNGEAPCRNCLQARKPTECVYPVREKKIPVAESYLKTLEAENKALKRRRSSESQQLTARNESSLNQLLNNTIAQQTALPGPSDRHKQRHVSGQPGSTNSTTPDPQHDPGMGFFSDESSIQPRYSGEASSETFGGRLHQYINHGERRPPQRSYIYYKNPKLLRISSTECNLPNKNYAKLLVRAVLRFIGGDHHLLLRKSFLQKLEETYHLEVLDDPVWLCRLFTVLALGELYSAGITGGALKGPGVPGTGFFVKAMGFFQDLHEEPTVSYVETLLLLSFYCVALNRRNTAYTHAGLALRLSLTLGLHRRIPEDSGMSAPEREHQVRVWWTCYALDRIYSSKVGLPIMLRDEDIDVQMPSMDGLTAEEAEDFYPPELMTAQIKLARITGMVMSDLYKIPQPGRANTFVQSVQRILTSLRSWHETLPKVLRLDFSAMPIYPSRSVASLHLHFGNAVIQTTRPILFHLFRSCFAEASATTASGPVSSMTAALGESCIQAARTSNSILAQLWVDGCLAPYGYFDALSVFTSTMILMMSSTMKEDNSSDNDAVETAWSLLRSMRATGNLPASGYYDQLVELKIDLDSLQKRSKSPHASHPDTEERDGLKVLLAASSSVGQQQPSSSQYNRGVNMPSDSGTFGVGDAMGALDDPFLQDFLQQPYGNWNSESFDPSSGLPPAQFQFEWENANLFGNPGSFFQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RV88</accession>
    <name>A0A3D8RV88_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_05829</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW77977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RV88"/>
    <dbReference type="OrthoDB" id="272703at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12398">
        <property type="entry name" value="RRM_CSTF2_RNA15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.70">
        <property type="entry name" value="Transcription termination and cleavage factor, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025742">
        <property type="entry name" value="CSTF2_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026896">
        <property type="entry name" value="CSTF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038192">
        <property type="entry name" value="CSTF_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14327">
        <property type="entry name" value="CSTF2_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14304">
        <property type="entry name" value="CSTF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="8"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="83"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="213"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="213"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW77977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="314" mass="33016" checksum="376748B9194F2C71" modified="2019-01-16" version="1">MSTKTPSKSVFVGNIPYGLTEEQIVDIFSSAGKVVSFRLVYDRETGRPKGFGFAEYPDSDSAASAVRNLNDFEIMNRKLRVDFSNDGGDDDNQTASTSYQAPLPTNGNYPPPPTMNAPSNSSLPALPTGVDLPPGLTCPDAISRTLATLPPAQLLDVLSQMKTLTSADPSKATELLNQAPQLSYAIFQALLLMGLVSTEALSSVVEAAAAAPTPAPQPAYSIPPPGSYSAGFPPPPPHMSGQLGAQIGTPPPNYGQAYPPPPPQRAPPAATPQPALSETDALMQQVLAMPQELIDSLPPAERAQLLALRAQFGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVE6</accession>
    <name>A0A3D8RVE6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_05901</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVE6"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012681">
        <property type="entry name" value="NCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00800">
        <property type="entry name" value="ncs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="254"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="338"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="492"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW78049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="555" mass="61921" checksum="70D3FE4C2FFB5C99" modified="2019-01-16" version="1">MQHSIRARATAVKENVISKRKSSGWVLKKETTSFAPPGTWTNLDTDVTPVERRTWTSWTMLFYWFSDILTAQSWEGGSSVIEAGLTWREALITLIMGIVIIVIPMVFNGAIGSRLHVSFPVAARSSFGFHFAKFAVVVRLCTALFWHSIQTYSGSTAVTQMIRAIWPSYLDIPNHLSASAGITTQGIVSHFIFWSIQFPFCLIAPHKMKWFFKMKVVVVLATCIGTVAAMLTLAKGSSGEIWKQETTIHGSKRSWMIMAYMMSMAGGWSTMATNIPDFTRYLKTSQGTYWQALFVPILSTTIACFGMICTSCAKVVYGKYIWSPLDIAAEWTSPGGRAAAFFVGFSWAVAQIGVNVSANVISASNDMSFLCPKYINLRRGAVITTLIGGWAMVPWKVVYSATSFLNFMSALTVFLAPCCAILCSDFWVVKRRNIDIPALYRPYARYRFHAGFNWRAIVAIIVSIGPNMPGMVYAVNSKVPIGGAIYIYDMNFLYGFFSAFGTYCFLSFIWPARETLLQSCIYSDEDVIEGQHRNVSVDGDSDPQKYIPREKVSPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVG8</accession>
    <name>A0A3D8RVG8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">DNA repair protein REV1</fullName>
            <ecNumber evidence="14">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BP5796_05909</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. Involved in mitochondrial DNA mutagenesis.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 2 magnesium ions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the DNA polymerase type-Y family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="14"/>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVG8"/>
    <dbReference type="OrthoDB" id="427711at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017125">
        <property type="term" value="F:deoxycytidyl transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070987">
        <property type="term" value="P:error-free translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17719">
        <property type="entry name" value="BRCT_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01701">
        <property type="entry name" value="PolY_Rev1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.100:FF:000001">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.270:FF:000040">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10190:FF:000011">
        <property type="entry name" value="DNA repair protein REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1630">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.100">
        <property type="entry name" value="DNA polymerase, Y-family, little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1280">
        <property type="entry name" value="DNA repair protein Rev1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036775">
        <property type="entry name" value="DNA_pol_Y-fam_lit_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017961">
        <property type="entry name" value="DNA_pol_Y-fam_little_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025527">
        <property type="entry name" value="HUWE1/Rev1_UBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053848">
        <property type="entry name" value="IMS_HHH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012112">
        <property type="entry name" value="REV1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031991">
        <property type="entry name" value="Rev1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038401">
        <property type="entry name" value="Rev1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45990:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16589">
        <property type="entry name" value="BRCT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11799">
        <property type="entry name" value="IMS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21999">
        <property type="entry name" value="IMS_HHH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16727">
        <property type="entry name" value="REV1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14377">
        <property type="entry name" value="UBM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036573">
        <property type="entry name" value="REV1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100879">
        <property type="entry name" value="Lesion bypass DNA polymerase (Y-family), little finger domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 14" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="10 14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="17">
        <location>
            <begin position="61"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="UmuC" evidence="18">
        <location>
            <begin position="421"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="290"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="816"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="933"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="992"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1110"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="294"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="933"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="943"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="992"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="1036"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="425"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="520"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="521"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR036573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR036573-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RDW78057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1251" mass="138364" checksum="F3C8D7100D0F4A15" modified="2019-01-16" version="1">MGSRLEKGSESTRKRIQAHSFDDEEGDEYEGSKFGGFTEYFRRKKIKLQNLDAELRSSSTQNPKLFRGIVAHVNGYTQPSLNDLHRLIVSHGGGFSQYLDGKTSVTHIIAANLTPKKAIEFRRYRIVKPAWVVDSIKAEKLLPWDAYRVVDEGVNQRLLGFDDGKIVAQANTQQRTYREQTNTSWYTSQVKTVAEDIDDEKEPHFPSTQPLFAHEVGYKSSHNAERVQHSQDTITQAHQLSAPGSSANFDVTSSLEDALKAVDDAEEDELDQMAGTSMTLAPGVALLDSEDTQDLSSSTKPRNTGSVATGNFLPGPSTRRTKHDQVTAFYKELLKDVPPPSKETEAMTAEEHNAILLADPHIRKSSTANPGFLKQYYAESRLHHLSTWKADLKLRFQQMALDRSPSQKNLFKRKPGARRYVLHVDFDSFFCAVSLKSAPEYIDKPAVVAHGSGTGSEIASCNYPARAFGVKNGMWMKHALKLCSDIKVLPYDFPAYEEASRGFYEAIIDVGGIVQSVSVDEALVDVTSLCLPAGGSDGLGINEGSIWREQEKADEIAAQLRTRIKEKTGCAVSVGIGGNILLAKVALRRAKPAGQYQIKPEEVLDFIGELNVENLPSVAYSIGGKLEEIGVKLVKDVRQLSKDRLMTVLGPKTGEKLWDYSRGIDRTEVGEQVIRKSVSAEVNWGIRFISQPEAEEFVQNLCGELNRRLVEQRVKGKQFTMKIMRKAADAPLDPPKHLGHGKCDTFNKSIVLGVATNSAGILGREAISILRSYGFSPGELRGLGVQMTKLEPLKSDALPEGSQRRINFGSAVPKLAKKATEDPIDDPESPKAQKVQPVSVCADPIDDIVTPQKPKVLRSQSQDGDDPIDDKISPLRPKPTPVHPAAIIARTNATDQSATKRLNLTGTQFIIPSQIDPSVLAELPQDLRSKLLAQSKSRPSSRAQSPAVVSRSQSPAVPAAAPLPSQLDPEVFDALPEDMKAEVLASYSSHNAHPYLRNQTLLPQSPRKPRPLPPKKTTPTKRRGRPRGAFNRPKPDTSSAYTQSNFNKSEFLSKSKDQTDSDGYVSDTLDPEFLSALPEDVRQEVIDEHRRNRLAKKSHLFLTTANVSKRPKAVQEGPVPGGRKLRLPPRPPKPTFTTMNLSKLSELRGTIKDWFREFKHEGPNIEDVGALERYLRRVVVDERDLSKVVGVVKWIAWLIEDADDQEERVGAPGGEEKGKGKRAWEEALKGIKDKIQDAVKERGLGRLELSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVQ7</accession>
    <name>A0A3D8RVQ7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_05743</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase S12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW77891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVQ7"/>
    <dbReference type="OrthoDB" id="5946976at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.50">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050491">
        <property type="entry name" value="AmpC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027279">
        <property type="entry name" value="D_amino_pept/lipop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012856">
        <property type="entry name" value="DAP_B_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009622">
        <property type="entry name" value="PRK13128.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825:SF9">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46825">
        <property type="entry name" value="D-ALANYL-D-ALANINE-CARBOXYPEPTIDASE/ENDOPEPTIDASE AMPH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07930">
        <property type="entry name" value="DAP_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50886">
        <property type="entry name" value="D-aminopeptidase, middle and C-terminal domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="17"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="D-aminopeptidase" evidence="4">
        <location>
            <begin position="355"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW77891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="540" mass="60273" checksum="AE5FFFDA027F3AE0" modified="2019-01-16" version="1">MSEQAEKLQHILETIPRLYRGPGGAIAVLKDGELIAQKTWGYADLNKRIPITSQTLMPICSISKQMVCALLMDLEDNPPPEIAAKGPFQQQMETALRSLAPSLLTQGTGLTVRHLCDMQSGLRDYWALAMICGAKPDDRFTIEGDGKTLLSMYKTFHFEPGTEYSYSNINFYLLGRLIEIITKEPLPKLLEERIFRPRKMTTAQLIPDTAKQPGNCFGYEGDEQHGFLPTVNRIEWSGDAGITASLEDMTAYETYFHRQWSEKGRYYTTASPQVYKDGHSAPYSYGLSHASVEGVATVGHAGALRGWRIQRRYVEQERLSVVVMFNSENLSAGKAADHIIKKALNLPEPQIPDITPDTAWFGDFLDRETQLSITVSRGPKLGQIVLRYARDPENVSIVAPDRAESPDNVASIDGDILTIRRVKENRTLVAQRIIEQTITDGSRLQGKYFCSEMETTFVCEGRDNMLYGAFDGPLGHGPANLMRRLGENVWAWACPRGLDHSPPGDWTIVFSEDADGVTNGCTVGCWLARRLDFPKSQDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RW89</accession>
    <name>A0A3D8RW89_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UDP-galactose transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_06175</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RW89"/>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="408"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="81"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="789"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="789"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="816"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW78323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="827" mass="91557" checksum="05D9706B37BEAE2E" modified="2019-01-16" version="1">MFRLFSHNRLAWLHGPQGAAYAAALGLIAIQVGIGIIMKISQSKGTYDFSPSSSVTISEFFKMLLSTIFFYRECKTRTANREPAHTPLPTSERNSFEETKPFAEDQTSGLNGNGHSMSPTSAYTPAANMDIKTFILFIRNEVSRDTRYGFAQLALFYALINNSIFVAYKLADPGTIQLTKSGVTFITALVMIATLGSKITKIQWIAIVIQICGLMVTQYHPEEGTAYPISTYLILLFQVFLSALSGVYNQALLKSDGSSLHADNMILYASGAAINLLLHLVIRVLKADEPGFFTGYGSIGACLVILSNVFIGLAITAVYKYADAVIKCFATAVATGILLYLSPILFGTELGFLVLPGTIVVFVASWLYMEGAAPKDTNASMPKPVNEPTQPSIFSKMSAVSRLHQRRVLGIATFFTVVVVAFLTMSNSIMPDRAKGKTVGSQPASNQAADLVLESPFKNTLAMVRWNSDHPERMPLLQQYAPFFHDLHFSMPGYVKGDAEFHNLTHDSFPSAEVIYTQIAKTMQLILDAPAGSATSEIEGLFYYHFDAWIDPLAYAGSNMHNIWFPDIVDQAPPNGGGPRFECMTDPKRYDWWGWGQKFHHASMAASAVVDHFDMDYNVNPHEWCIGWTDIYYVPRRFFADYIFLSSIFGGFSVFHEVAVPTMLHIIDESRRRHPSRSIIDRFGDCWGSCCASNPNVQDILWNRCGHRLDYVNEKVTAVHYERLGNQTAMLGEPIGETVYAHKRPTSPNAFSAETLTALTVDEHGVKPANVTSESINEANAEMDRLARQREKNLEKIQDASESVDGFLEPEPNPLTDGSSKSTVQEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWK9</accession>
    <name>A0A3D8RWK9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DRBM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_06218</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWK9"/>
    <dbReference type="OrthoDB" id="3429652at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00048">
        <property type="entry name" value="DSRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014720">
        <property type="entry name" value="dsRBD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00035">
        <property type="entry name" value="dsrm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00358">
        <property type="entry name" value="DSRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DRBM" evidence="2">
        <location>
            <begin position="262"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW78366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="332" mass="36997" checksum="EA6D09F4231DAA68" modified="2019-01-16" version="1">MGASSKLSRTFKAFSLNSFACFNLHTDRSDTKAAAETRPTKSLDPLKFDYPIGGISELPSSHTMETFPQPVELIANESIINHDSLLGHKAVEKAIMTDTLRHIGRNAPLNVVTDIFKEKSLDFQYEACLRELCGGDELLEPNSDIRILLFERIGHIILRGKDNESQNLDFKLERHVHDRRRFQNEKYRALQPSNDENIQHAGNSSAPFAGSFPPGRSTDQILPSSPPQSDSRNATVQGDERPPSPPESSAGGDDELENMGDYTSRLLERGAKMGLVPMYEEKETSSKPKRFEGTVTFGERRAVGRVCSSKKAARHEVSKIMLNRLAAEERVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWT1</accession>
    <name>A0A3D8RWT1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_06310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWT1"/>
    <dbReference type="OrthoDB" id="433738at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF3">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="148"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW78458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="200" mass="22329" checksum="63AF47C7E070838F" modified="2019-01-16" version="1">MEDPETFDALPIRIDPVSKAIGTTSSSKALNEELEKLNALHRSILALETPVPPPPMPVNQKRTAGITKLRETGNDAFRKGKHAEAIKYYTLGLQMALGRPLWEPQGLVREEVAGIYANRAQAHMAMQNWVEGAVDAEASVEMKRVGNAKAWWRRGKCLMEMGRWEEAKEWIGKGLELEGSESDLTSLLKEIEKHVDVQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3K3</accession>
    <name>A0A3D8S3K3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_05570</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3K3"/>
    <dbReference type="OrthoDB" id="10009520at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20339">
        <property type="entry name" value="BRcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20353">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16630">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047545">
        <property type="entry name" value="BRcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051628">
        <property type="entry name" value="LUBAC_E3_Ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047546">
        <property type="entry name" value="Rcat_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047544">
        <property type="entry name" value="RING-HC_RBR_RNF216"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770:SF47">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22770">
        <property type="entry name" value="UBIQUITIN CONJUGATING ENZYME 7 INTERACTING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26200">
        <property type="entry name" value="Rcat_RNF216"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="404"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="367"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW80872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="834" mass="94091" checksum="44B8DB6C2609D4E4" modified="2019-01-16" version="1">MFRAQRQPFRWQPGHEVIDLDNEAEVDGSPAREVIDLGLDSEEDGIAPKNNDILNRINLGGRARKDEIVLDDSDLEDFYSPADPQTRQPAAVKQQLVQDREDGGLDDFILDQSRSDSLEKGDDDDSVYFDLELGQSERGFHAALASNGSIEAEDNASLQDMLAQTKGKSIPAVPREQQEVISPKVQTKAACIDTVAAMFPGICLNYAEGIFHSISHDSEQLIAHILDQAENGEKWPKAKDMQKLLKRKREVNEEDEAIRKYTTERQLADPMHDMKILIKECLQEDFVSTPMTYIEAVLKQDNYRLFPAYIVLELAERTWDSRNPTYLKLKKNRKVRNAYLDKSNPQLLDAHLENDHLEIQTREILLEFQAARKLRRKQDQAREAERQLVAAEEQNLLEAQREGLMSECGCCFCDHPINRMVYCDKDEGHMFCRGCARQMAETEIGNSKKLFLDEKSTIALERNEQEAALRMAGIENLASCPFCPYAAEYPPVEVNREFTCAAPDCERVSCRLCRMDSHIPKTCAENAKENSLSIRRQIEEAMSAALIRRCNKCSTPFVKENGCNKMTCTRAGCSNTQCYVCSKPAGYDHFNDLTRGGKVGNCPLFDTQDLLLEQRHENEIRQAEKVALAKIRADHPEYTEDDLKINMSEKVAEDDKRRRAEHDPRARVLANIVAGRLDRYHRRHLNQGLAQPQNPQQPGDAVDLRLFNAMVLARAEDLNIRQAPIRPGGPDNIRQAIAVDRGVHPRLLRGGNAAIQQGEVQAQAPRAYALGAAAVPPQPELLLDRGRGIPGYGMDDFRDMHFMLGGPLRQGLARLEAGDRGDAQVQNLLQGDWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SA40</accession>
    <name>A0A3D8SA40_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04708</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SA40"/>
    <dbReference type="OrthoDB" id="2129362at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW83217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="728" mass="81339" checksum="3D80B02B2B8A4675" modified="2019-01-16" version="1">MADLANVPPDSSGHVSMWADPAWKPGMNFTEWRRAQPQYLKDVPYNMQAAPKKTVGSKSPPTPLSIKTKPGGYLPPHLRGPCSSSGPDAKQETMPLPPHLRGRESKTPSVRQNSIPSQLRAVDSGNPKSQQVAQDPTLANNSSSTGPSIAETYDTISTIPQGTSITRTQVKPITMPSTLTTPNAQPSQHLQEQAFLESVGLLPRMSNTPPHLRGIENEPRHAPPKQMLSASTLDLSSQSFRLPQSSKKPHTLKPFLQEEALNRLIAQTGLPFHDPKRLSQMMIEELNNSSSKDNRKIDSAQAPAPSGPLAEKSRISIPSNISLSGRVSDAGIVESEKSRSALYPLRENIRARQGIDARELFLDWDGKTWMPPPVDWENDRGTFDDSFIPEYCKEWALGVEGSGQITNISGEGFRSGTHPINNGKLADPMPQPESHPDLRNCENEEKRRMQTAETESFRAKKRLEKRLRSQIVHQETSLPPYEPAQLVFPESNRYKPLIDIYLRPATNKDVSGMTAIFNHYAEEGILTEDQGPIVESVIRKLLSILEEENAPIVVAIKGHLPEPRFQRGKKTIILPQFELVVGFVFLRRHEYTLNDGDMGRSRYTSNLNIYVHPEYTRKGVGRSLMDRIFQCASATYSAKDGYDWYNPSEHPVYKSGGGRQCHQIVANYMTFNGDPNLEWVQKLLEEFSFKKVGTIESAGRSAPCARELKWLDAVIFQARASRAIEIYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAJ9</accession>
    <name>A0A3D8SAJ9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_04662</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAJ9"/>
    <dbReference type="OrthoDB" id="996720at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002673">
        <property type="entry name" value="Ribosomal_eL29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01779">
        <property type="entry name" value="Ribosomal_L29e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW83171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="84" mass="9563" checksum="BDD71E2F102DB7F7" modified="2019-01-16" version="1">MASKYRAPGENKTIRINPICAESKNSSQHNQSKKAHRNGIKKPKTSRYPSLKGTDPKFRRNHRHALHGTMKALKEKLEGKRDTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAT6</accession>
    <name>A0A3D8SAT6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04874</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAT6"/>
    <dbReference type="OrthoDB" id="3938623at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045142">
        <property type="entry name" value="BCAS3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13268:SF0">
        <property type="entry name" value="BCAS3 MICROTUBULE ASSOCIATED CELL MIGRATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13268">
        <property type="entry name" value="BREAST CARCINOMA AMPLIFIED SEQUENCE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="757"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW83383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1126" mass="120531" checksum="5D0778AAC240B70B" modified="2019-01-16" version="1">MSPSSDQDSNNPSSGNVTNGKLSQKLSPAGVQIPSKNGKKHGTAKDKDNGVLAAVTKNASKLSKQAAASKWQSPKMEPATPAINDSTEPSPLLEDASTPAINSVNNQNTSEWAKNVPPYSSSPSNLINLGESPPTLPSSYEERGANFGGWTAREQRIPHSHNPSASPPAGRRRPLSYQLDSNFQHSPDEHFNQMSPYGRRTSLYSQHPRFNQPPLPHQAQAHFYGAPDANMLLSPRMPGLTPGENGFFCGFDLLPNQDFAKPADNVVINGYDGGLNMYTVTKKGLDKVLSIDGIRGGVYHAKIIPWTIRGGTSDDYPLVAVVVHGPVSSSSDVSSAELAVSDGNSVRPTESARGSPRPTQGQQPTEHHAYQTSVEIFSCNTRQHVATLLSLSSSPYTNSMQSPLLAPFAPEGSLTVRADDGKIVVASGSSGETWIFCQDETGLPKFRCIGKVWTTIQQGLSVNPGAANSNVDGDWASHDLVQPQQKSLKTPILSLHGRWLAYCPAAPASVVTSRAAIPGISTTTKVPGLNSLAPPNLPPANCAVDMPDGESMIGKIAQVATQEVIKGAAYVGKQSLQVWNHYWNKSSTQSSNGALPYQTQTSAAQFPPTHAVTNQTAVTNKDPGLISILDLNALALYSSGTTVPHPLVTFKVPHGCSFLSFAPNGLSLFTASSKGDIQFVWDLMRIQYVKSSLLKGSFPGNGPPGIHVRRIARFSRMTIARIVDVVWTKPHGERIAMVTEHGTVHILDLPASAFTWPPPRRKATANSSKDQAPGTEVASTSLTPASVASSAVSSLWSAAQPLVRPRRSSSGVTNATLPSVASHGSHGTQAFAAGFSRSVGAATGKMNEMRKYSSKQVRVQLPPSAAPPGLCCVVVVGGKRNDSIIVVGGGIVRVYTIKSRRADRPADKQKPSRGAKFVEYRLPSLPDSKLAPDNLSNLHLDEEFDEVQDLRWRKATVTPGSKATHIGTESSIPQAEIESNAPYQPFHTDRRVALHIFSHEEAQSSSPSVSALLSPNLAGVKASRTTQKKSAWAFGGPIKATKLDVGPLPTSDDDYDGPFDHRALPLSAIERFTRVAESSENIDQIVITTRRRKGAPRTGDENGVDIDEEGFFEDDCEVLDFASQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SH58</accession>
    <name>A0A3D8SH58_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">PAN2-PAN3 deadenylation complex catalytic subunit PAN2</fullName>
            <ecNumber evidence="10">3.1.13.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">PAB1P-dependent poly(A)-specific ribonuclease</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Poly(A)-nuclease deadenylation complex subunit 2</fullName>
            <shortName evidence="10">PAN deadenylation complex subunit 2</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">PAN2</name>
        <name evidence="13" type="ORF">BP5796_03985</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10">Binds 2 metal cations per subunit in the catalytic exonuclease domain.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Positively regulated by the regulatory subunit PAN3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase C19 family. PAN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="10"/>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SH58"/>
    <dbReference type="OrthoDB" id="16516at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06143">
        <property type="entry name" value="PAN2_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02672">
        <property type="entry name" value="Peptidase_C19P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000459">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex catalytic subunit PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000028">
        <property type="entry name" value="PAN2-PAN3 deadenylation complex catalytic subunit PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03182">
        <property type="entry name" value="PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030843">
        <property type="entry name" value="PAN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050785">
        <property type="entry name" value="PAN2-PAN3_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048841">
        <property type="entry name" value="PAN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028881">
        <property type="entry name" value="PAN2_UCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728">
        <property type="entry name" value="DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728:SF0">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20770">
        <property type="entry name" value="PAN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13423">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="USP" evidence="12">
        <location>
            <begin position="481"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="386"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1064"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1121"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="871"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="873"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="980"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="1033"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW85660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1145" mass="127818" checksum="31BA541D56173F31" modified="2019-01-16" version="1">MDADWEEVARLALPPPGLNALQTPVKTTAFDTHQELLWTGNEYGRVTSFYGTELQRYTSFKAGEGPVRQLLFHDKGIVALTPRAVHMSMRRGPPLWHIAHEEMKDLQCMSYTSKGTSEILVAGIQDVMFVIDVNKGTITKQIHTSDHYMKMQRSRYICGATKTGTVNILDSITFNVIKTWTAHSALVSDMDAQHDFIVTCGFSIRQLGNYMLDPLVNVFDLKNMKPLPPIPFPAGAAYVRLHPRMSTTCIVVGQTGQMHIVDLMNVNTSNVKQANCLTYLTYLEIAPSGEAIALVDAECNIHLWGSPSRIRFAEFSNPVDFPDPIDEVPTLDWSPDTPLSSIGMPYYREQLLSGWPSHMIFEVGAPPVKMEQQPLPGFKTAEWGSYGRNPRGVRRNQIENTRAIEKKNESLQAPRFLSEKAREAANDASSERRISDASESLSALDLSKSEIPRRYRNVEIKYSKFGVDDFDFGYYNKTSYSGLEIHISNSYANPLLQLMHFTPIIRNMALQHTATSCSNELCLLCEMGFLFDMLEKAEGSICQATNMLKTLSCHREAGPLGLLEEETPGSSLTAMLQGLNRFLLDKIVQDFRSIPPRSTALDQVLATPATTAIRCMNCRSEHTRPGTTFVNELIYPVPKIVVRNPRTPKLSFSQILKSSVERETTSRGWCSRCQRYQSLQTRKTIHNIPAVLMLNAAVNSPEAKQFWSTPGWLPDEIGVIVDQGQFFCYQGEDLKLHLQRGIHNVIVYSLVGLAADIENGPNQKSHLISLINVGHSKPTPPTESQWHLFNDFLVAPVSKDEALAFNTTWKVPSVLAYQIKAANNQIDNTWKQNLDTSLLYIDHNRNPGPKTYRPLVPPQEAPTEGTIVALDTEFVAIRQPEIEMNSDGERETIRPIVYALARVSVVRGSGEDEGLPFIDDYVKSKETVVDFLTSYSGIVPSDLDPRVSKHNLLPLKIAYKKLWILLNLGCKFLGHGLKQDFRVTNIHVPKSQVIDTIDFFYVKSRLRKLSLAFLAWYFLKEDIQLETHDSIEDARTALKLYRKYQEFNDAGILETMLNDIYSKGRETNFKPPPPPKSKGAPEILRTETPPILSDGSLSAAALEGPTTPVRKPISGLLPGSAGTGGFGSGGWTPGRGSGLGGSPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHB1</accession>
    <name>A0A3D8SHB1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Class E vacuolar protein-sorting machinery protein HSE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Class E vacuolar protein-sorting machinery protein hse1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BP5796_04060</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endosome membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the STAM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHB1"/>
    <dbReference type="OrthoDB" id="10255964at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11805">
        <property type="entry name" value="SH3_GRB2_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16978">
        <property type="entry name" value="VHS_HSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000072">
        <property type="entry name" value="Unconventional Myosin IB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004152">
        <property type="entry name" value="GAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF3">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03127">
        <property type="entry name" value="GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00499">
        <property type="entry name" value="P67PHOX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0967">Endosome</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="8" id="KW-0813">Transport</keyword>
    <feature type="domain" description="VHS" evidence="15">
        <location>
            <begin position="16"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="14">
        <location>
            <begin position="212"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="136"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="368"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="180"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="393"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="476"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="495"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="522"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="539"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="13">
        <location>
            <begin position="566"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="598"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDW85735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="643" mass="70481" checksum="2EEE21EE13EE4A0A" modified="2019-01-16" version="1">MFRAQQNAFDDVVAKATDENLTSENWEYIMDVCDKVTGEESGAKDAVASMIKRLAHRNANVQLYTLELANALSQNCGPKMHRELASRAFTDALLRLANDRNTHQQVKAKILERMQEWAEMFTDPDLGIMNDQYHKLKSQNPNLHPPSAPQKSRLTDVDRQKEEEELQMALKLSIQDKGTPGPAKAQAGPSAGAAQTQAAAPQQPVPSGTTAATVSRVRALFDFQATDPDELNFRKGDVIAVIESVYKDWWKGLLRGQTGIFPLNYVEKLADPTPDELHREAQMEAEVFAEIKNVEKLLTLLSTSSSDMNARDNEEITKLYHSTLAIRPKLIELIGKYSQKKDDFTQLNERFIKSCRDYENLLDASMTSQPSYQYGRPQGPPQGYGGYPPQPHPQAGQPGPQRQYYNQTPQQEPTQQYPQKTSSPGYPAPQRNQPAPFYIVPQQAGPGGPSGPSGPPRDPVQRIPSAGQPAPSHTSSPPPNQYPQSAYPPPLQTGHRPQSTYAHPQELASQSFDSPVAADPNSAYSASVYSQEDGNPYTASSANQQPPSQQYSAYVPPSQHQQQPGYAPPQPPGQVPSPVQMVGGAGYPVIGADARANLPSQTQYKAYQRPGSSEGQVRPRAPSGPSAPPGGSPQDYYRQSAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHK9</accession>
    <name>A0A3D8SHK9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Smr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_03969</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHK9"/>
    <dbReference type="OrthoDB" id="443981at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14279">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052772">
        <property type="entry name" value="Endo/PolyKinase_Domain-Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058864">
        <property type="entry name" value="UBA_10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46535:SF1">
        <property type="entry name" value="NEDD4-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26286">
        <property type="entry name" value="UBA_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="460"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW85644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="550" mass="59548" checksum="978A08A14370BB28" modified="2019-01-16" version="1">MSPPSLTEQELQARFEKEYCPPLDTATLLAIIQDYDLTNEAQQVEARQTLDIIKESAAEEEATGFDPSGSSWIQPGPVDDTANGLTEDGSLSARSHPEWASTTDGTSISQGIPAVDLDGVDSSEALRETHGRSDDVYGFDLDGLGDESKESLLLGIFPALKPFDITWTLKKYKGDASAAIDELMNQSFLEESGARHKGIDAFSESELSSKQRKNKGNKGRNRRMEDTSQSSTESPPTNSKWDTGRQDVEFISSKTSMPVEQVSSLYHKNGASLQATISAIIDAHAALNINTEDDAVLQLHAHELGKQFSSISPSDIMTLVQITHPSQGFAQDLAEALAHRPSTTKPGLHLEFRHAPIDLTPEIRSSRWKPQSHNAVHAEGTQTYFDSADASAAASAYRATRNDAFAKASTAWRKGKSDHLMGAAAAYYADLGKEYDVRAKSAESAAADALVATQSSWDLLDLHGVNVKDAIRISRERVTTWWHGLGDARISGRAGSYKIVTGLGIHSKEGKARLGPAVAKMLMREGWKVEVGQGTVLVTGVVRTPATTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHM3</accession>
    <name>A0A3D8SHM3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_04097</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMP52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHM3"/>
    <dbReference type="OrthoDB" id="430436at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051170">
        <property type="term" value="P:import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000366">
        <property type="entry name" value="Protein FMP52, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014843">
        <property type="entry name" value="Him1/Fmp52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14097:SF7">
        <property type="entry name" value="OXIDOREDUCTASE HTATIP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08732">
        <property type="entry name" value="HIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW85772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="230" mass="24198" checksum="E4D8D5D703191013" modified="2019-01-16" version="1">MTSTALVGSTGLVGSHILSTLLSLPTNSNVYALARREPKVQDNKLHPLISSESSSWSSQLTSISPPPSIFYSSLGTTRGAAGGVENQRKIDYDLNLELAQAAKKAGVKVYVLISTSGASSTSRMAYPKMKGELEDAVKSLGFDNTVIVRPGLIVGAREEFRGPELVFRKLAGALGSLSSALKDPWAQDADVIAKAAVAAGNKALAGEAPTAVWEVGQSEVVRLGRTEWKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHV8</accession>
    <name>A0A3D8SHV8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_04260</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHV8"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055497">
        <property type="entry name" value="DUF7069"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054471">
        <property type="entry name" value="GPIID_WHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23239">
        <property type="entry name" value="DUF7069"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22939">
        <property type="entry name" value="WHD_GPIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="7">
        <location>
            <begin position="499"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7069" evidence="6">
        <location>
            <begin position="702"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="domain" description="GPI inositol-deacylase winged helix" evidence="5">
        <location>
            <begin position="786"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1072"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1105"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1138"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="57"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="446"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF22939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF23239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW85935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1164" mass="133344" checksum="12980BA3475C1AD8" modified="2019-01-16" version="1">MAPKRKAREQLAGHLQKVPAHEGHASGVRRQRGQLLHLKSRHPSLITLAAGQRRIQNEQNNEQPQQASSSNQHPNVTDHERADQHSLGNSTNTRPFQNTRLRTKERGISQQRPPHAASSSPPRPHRYEQHDQKEREEEIQTRRDLDVDANHDFIFDTALNVLRIILEYESSRTFLVYAHENEHSEKKASQKIAQKLINWLNCIGTNLQSDQLPKGSDKGTFFCHSVHDEAVHDILHNQMCLLPRRIHSESVDKVILCGSELLAEYMESDFYQTYRKAIHYTFNDVEKTGNEIKESWRQIVENSLDKPGFHHVLTEVALLELPEKKPETSAKIIPVELNGECNKILPANLFPPTNVRIKSTKAYTEVDLHKKLFTLLPRIFERKDSAIKKVEMAYHMCMKIPTDSEMYRASVINKFYHEVFRKLEDDMRSISFGDFITKLRYLPAQMTQIQGTLKFLQEKAVSAEEREQLAREEKCHQALFPLGMDYSHQKDQNPQRVPGTCLWALEHENYFRWKDNNTQRLLWISADAGCGKSVLSRCIVDEDLPKTLHRTRSCIIYFFFKDTSDDQRSARKALLSLLHQLISQRHSLIKYVLPLYKEQGDKIKDASFSKIWSILMDSVKDRETGQVICLLDALDECRQEEREDLISSIGEFCISEKRSPRCDLRFLITSRPYLDLKAAFANIVNTSMGIQLDGTTESEQIKMEIDLVIKHRVAELDRKLSFPVKVRDYLQKTLLEMEQRTYLWLRLVLDSLPKRWPRTVTMMKKEITTLPKGIDAAYESLLTKCDDEEYTRKVLEIVLAAYRPLTLKEISEALCISEETRSYSSLDLEDEESLQELLPGRCGLMITIIDSKVYFIHQTVKEFLLKKVDVQDFTHGRHKIEENGAPQESVWNGSFTNQQSHYRIAMACMRTLLFPEISTKDFDACQSLIETYQRTTEREHGHTPAFFSYTALYWADHYRDCQRRIDIEKRLVPKNVLISSKESQVIGTVAQVAAAGQHEQIFNLHIDDISNIDEITDGQYGTLLVAAAYGGNIKITRKVLVDRRAEINTQGGREMVELLLSRGAEVNTQGGSYGTALQAASGRGHREIVELLLSRGAEVNIQGGHYGTALQAAIVQGHREIVELLLSRGAEVNTQGGRYGTALQAASGRGHREIVELLLSRGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMU7</accession>
    <name>A0A3D8SMU7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">feruloyl esterase</fullName>
            <ecNumber evidence="2">3.1.1.73</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_03331</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.73" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SMU7"/>
    <dbReference type="OrthoDB" id="424610at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043595">
        <property type="entry name" value="FaeB/C/D"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38050:SF2">
        <property type="entry name" value="FERULOYL ESTERASE C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5032683398" description="feruloyl esterase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW87637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="315" mass="34644" checksum="5CC2B5FBEBD0EBD9" modified="2019-01-16" version="1">MAGLRSYLLLVAGLAHASQIILSPPIKGNVAYTLPTERTFLLNVPEAYTHGEPHPLVLSFHGAGGFSEKQQRITELSDPSLSIAGKPFMTAYAQGVNNTDWNMNHIWKGAPYENTTVDDIAYVYDIISTISATYTVDISRIYACGKSNGGGFTALLACRPDTSSIFAAFAPVSPALYQGTYAFHNCSPSHATPILHSHGVEDTITPFYGRTPEGGSFGPEPDVRLWRRMWAERNGCRGEYDGEWPRPIVREVHPGTWLETWDCPGTEVEALTIEGLGHAWPSTLGLDLAGSPNHTANFNFTSQYLIPFFSRHRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SN65</accession>
    <name>A0A3D8SN65_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TEA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_03318</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SN65"/>
    <dbReference type="OrthoDB" id="10006572at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.40">
        <property type="entry name" value="TEA/ATTS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000818">
        <property type="entry name" value="TEA/ATTS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038096">
        <property type="entry name" value="TEA/ATTS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050937">
        <property type="entry name" value="TEC1_TEAD_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834:SF0">
        <property type="entry name" value="PROTEIN SCALLOPED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11834">
        <property type="entry name" value="TRANSCRIPTIONAL ENHANCER FACTOR TEF RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01285">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00426">
        <property type="entry name" value="TEA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51088">
        <property type="entry name" value="TEA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TEA" evidence="8">
        <location>
            <begin position="117"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="TEA" evidence="6">
        <location>
            <begin position="117"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="44"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="670"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="47"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="65"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="84"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="713"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW87624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="746" mass="84093" checksum="A0CEEEFBFBA45AA9" modified="2019-01-16" version="1">MDHRRHILPSSFNAQDDPNGQSRVRQPLSDSAGNAQLHALASGGLYHDNKGSQPRVDRPIYTIPTVPSQPARQFNPNSLELRRQTTRRRRQHRHTRNPIHDSPQYQAYRARQIRDGAPESDQKWPEILEIAFLDALIDIPPMGRRKFSLRGKPHGRNELIAEYIWIAYQQGLPPGQKPDKAMMRSRKQVSSHIQVLKGFFREHPAFLRLFPAPRGANKNGFDDNFKSDATLRALSEGRVLSRRHDQYLEINQIINSNHVPMRPATFWLLISLGADPNGSWKYKSEEDIHNDRRVVHRYTGLSAERPRTSLESIPNWRLKWPFLATLHAANDLACDIIHMDVSLELTNEHAPEGAELLSRTEMIIPGTAFADSHWQSITSLTKPEQLYGHEEEVPHGATAFPIDVAEVTDTETRLRLQFPASPWAHAFTMLTRLQYQFEDMQKSQSGGNSNVRGPNKTARELINEVSMYQELRSAAPGMPYIRRAVIVWTFSKTKAGESGKTSWSYLDAAPSRSMIMSPPPHASHHVAASMNEQFNTWAETPLHLQQHNIMDTFPPGLVTPPQTAGLQSPFGSNYLNSMSHYDMPSEHLSFVSDATVDSDSTLVNHDNTTNIDNFLSVPSTTLGSDYEQSASNWHLPNTEVFDADPAWASYSVPSTTAQLNWDSPAKANHTWNETQESQASEKHDWHSNAVSPTKQGYTEHDNENISTGLPPLNATTPVVSTTASQPQNWVSSDAFDYEAHLGNRLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SNL5</accession>
    <name>A0A3D8SNL5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Knr4/Smi1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03613</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SNL5"/>
    <dbReference type="OrthoDB" id="2788868at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018958">
        <property type="entry name" value="Knr4/Smi1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037883">
        <property type="entry name" value="Knr4/Smi1-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09346">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00860">
        <property type="entry name" value="SMI1_KNR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160631">
        <property type="entry name" value="SMI1/KNR4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Knr4/Smi1-like" evidence="1">
        <location>
            <begin position="276"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW87919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="469" mass="53246" checksum="24278076C50DBACE" modified="2019-01-16" version="1">MFLQGFLEDDILAERSTDAVVANASLKAVELAMLGLPDEANAIFTLLHPTGSLRYSSQMEFFFAASGMRRPDGTEPLDDQQLAPLEQRALESFGHLPRDINFANIDETSYEKITSIVNDLDSRNSPYKDARTGFQAMLMSAGVTALLAMANVLGHEDQASNMMNRITLRIQANKQSVYLSLVRSAWRPYFLSGWLRDKLGMTVAELQQYAAFVLQTTKTRLENGPRRIDDFYADKDVPQLLDELSRNTVTSPDYTSDVYRDDHVGDTAPISVLGRPATEEHITATETRIGHRFPEDLKNFFRITNGCLRVKVGSPPGQIFQRRLVSLGFMAWEDSCFMASSTFYLLPDIPKIDFDWPEFENGAIAMYEHSGQSTQYIWMVPEAPVQIAKQRVQDVYERANDETKAIIDQEINFRFGSREAFNAMTVCFFQQYWGEADGEAFPSFRSFLNRVVYESREMPQRSPLKLPVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SP10</accession>
    <name>A0A3D8SP10_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_03222</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SP10"/>
    <dbReference type="OrthoDB" id="17948at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002738">
        <property type="entry name" value="RNase_P_p30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01876">
        <property type="entry name" value="RNase_P_p30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="247"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW87528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="337" mass="36843" checksum="D3DE7C03C0944F7F" modified="2019-01-16" version="1">MLYDLNVAWSATQQPQELQRTISFLSELGYDTVALNDNVNVPLPTKIINPIPLEQSFPLPKKTTLLRRCTLHFADPSQNYRLPELARAYDILALRPTTEKAYLAACTALSENSIISLDLAQRFPFHFRPKQVMTAVNRGIFFELCYSPAAVGDSTSRRNVINNVLGLLRASCGRGLIVSSQAKNALGLRAPADVVNLLCVWGMGREKALESLGVNPRAVVVNEGIKRTGFRGVINVIDGGELPKNEIKENEKGVTKGSQGGDKTGKTDKTNKNKRKVEEKESNPDGTPIISKRKAKKMRLEALKANKTTLTTAQEPDSANSLPQSNTSGDTTPNTNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SP39</accession>
    <name>A0A3D8SP39_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_03252</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SP39"/>
    <dbReference type="OrthoDB" id="10301005at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW87558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="76" mass="8527" checksum="6BB7CBB0F054D78C" modified="2019-01-16" version="1">MSSALRASLKIRETTAFAALLLAFSPAVVLGTPLALERFPRTRFTQSRFWRQAQGQFDGQRVKHALEVILRRGRGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXK0</accession>
    <name>A0A3D8SXK0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SXK0"/>
    <dbReference type="OrthoDB" id="3530648at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="26"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="286" mass="33198" checksum="2B7D55340BC54B45" modified="2019-01-16" version="1">MSHVVCWEELTRTLAEDAEGSSPRTFTLFPKLPKELRVRIWFYALPDPADVRLEPDPRSWRFKRESIDGNVDKNLFAIVGTWKNIFKEMPYQIAPPITLRINRESRQETLKHYALFFHQDVPGLLHNPALKALPKRPFFFSPSRDTIFVPVVGFEDDDCDLPGWLTHLLNIKPAWAEKFRTMKFTGMECDETLIRDFKDCVEHSLAQDSRSSILGSLLRLPRLTRIEIVFEPSNVDEAHANTCRQEFGVLLLNFFSKYRRHFLGGHIPTIDLQSIIPEKAEDESSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXT7</accession>
    <name>A0A3D8SXT7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PRELI/MSF1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SXT7"/>
    <dbReference type="OrthoDB" id="341300at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="52"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="290" mass="31974" checksum="5990004851937BA5" modified="2019-01-16" version="1">MRKLLIITTSQPHHPISSSSSSLPLALSNHVSHSADVFIAYPPPLGKAVTMVKFYESSYSYSYSFPAVALAYFLRYPNPYSTHVLSTDTISRVIDPVTGRLTTTRIHQKRTRLPPAVMKLLPKSVLGNISGGRSESYILETCEVDVKEGWMRTQSKNLDWTSILSVIESQEYRSVPASSAAAKGRGEESTDVTTTVTFRSRMGERLRARANKVKDENEVPESNGFFANLGKSGIQRSIEAIASRKTENQLGKAKEGMMVVLERLRSGGLGGVLDGMRKDRELVFATAVNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SY54</accession>
    <name>A0A3D8SY54_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_02354</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SY54"/>
    <dbReference type="OrthoDB" id="269919at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10470:FF:000008">
        <property type="entry name" value="Translation initiation factor 2B, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051855">
        <property type="entry name" value="eIF2B_beta_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="467"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="492"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="17"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="236"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW91189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="618" mass="67643" checksum="E09B373EA74C0626" modified="2019-01-16" version="1">MLRCNYRGGWTEAAYKKAQKNHSKVERSGRTVRQGSSEVEKQKQPVGRQSGNQRPLSKPQAKKPKAKIPTRNWLASVYITETETKAFHLQTEEPIFQKNSSAGLAYIECRPYCATYPSKFETCISSANGMAPAQAGYAPDLSAFLKSLKVQSLEKSIENLISLFKRRQIKNSRSCAIATAHLLRQVVAKSKWSDLGKLLERIQQVGQRLMEAQPREMVVGNIVRRVLGMIREEAKEDRNEEFSDSGSNSQKASPRREPSDLSLSKAGAVPPIGTFSPLRFESNIGPDATFESSSNDDIFGKNSRPPLITSHASYAVLNGVPVQQSMFNLLSTNSSPSSTPVAASPVGKSAPSSAAISHRISTATLDLKAEIMNGIEEIIDELLQVDEQIAAYAQEHIHSNEIILTHSSSGSVQKFLLKAAEKRKFTVIVAESYPNDHEATHAAVTGKTSQDEKSVDEMSVGTFMKPLAAAGITVVLMTDATIFAIMSRVNKVILATHAVIANGGLIAAAGARIIARAAKVHKTPVIVVSGIYKLSPDYPFEFESLIEYGDPGSVIGYDDGPLVDKLEVDNPLFDYVPPDLVDLYITNLGAHAPSYLYRIVADHYKPEDINFHKPELQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SY78</accession>
    <name>A0A3D8SY78_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02421</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SY78"/>
    <dbReference type="OrthoDB" id="21418at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38645">
        <property type="entry name" value="CHROMOSOME 9, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38645:SF1">
        <property type="entry name" value="YALI0F12243P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="275" mass="29543" checksum="44CE5A5C944A64E9" modified="2019-01-16" version="1">MDSMRSLNTSLPGTSPSKTQPSEPPEQLLQAFKAAALSVTKLYKTAAADQGRARSEGYQDALDDLLTFLDKENIGLSDGEGWRIRRWATERLDGRDSMPTESDDEIVEKVPVERASSPVAQRSNSATRASNSTRSARTASPVRMESAPPTIPEGNHEHVTNMVPPQGNFTFRSSHAYPQDADMDLSNLDLSDNGRGQGHDATSHAASSAPGITITRPSRGNPRHNTPRNTRSSGTIGRGAGQKRKINLGDFFDIGNLGPKDGFGGGGNAKRGRYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYR7</accession>
    <name>A0A3D8SYR7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Chorismate synthase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYR7"/>
    <dbReference type="OrthoDB" id="4218123at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39470:SF1">
        <property type="entry name" value="CHORISMATE SYNTHASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39470">
        <property type="entry name" value="CHROMOSOME 10, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="356" mass="39399" checksum="F6352200A1363391" modified="2019-01-16" version="1">MSISWGTIKQIAILVGPMLLPKAIGYYRSVRAAPSIHGIPIRPVPANVARALAILFITAAGFLFKSLPFFSPENIFSLTQSRLQIPTDVLFTRLSGLRTAGLTATDDILRSKINSLESRLLYLQFGPGVITDCQFCNVEDPKSYLYYALPAILGPYLYNLCILALVTSGLFIGKEGAVWRTTATLAGSAIALLEVYLVSSYHYQGNARATRLEDLDAFYWKMRIYRSLMIAAVDGVIGWVLYLSSTNRAFVNPPSTAERVETATRIVEMMRSKLNAMGIVRNTVNRDTDLRTRSQNYWVQESMIMGALMEDREVIDGVKNALENRINMQTIATDAGTYAENILGPIEADLGMNGQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZ07</accession>
    <name>A0A3D8SZ07_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02566</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZ07"/>
    <dbReference type="OrthoDB" id="10293937at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="354" mass="40339" checksum="1BAE11A93EA8D9EE" modified="2019-01-16" version="1">MTLEGRHLAGSKPLQLPSIDEGFGSMASQYESTSTTSVKCETCAARGHTVYTIQGSPCPRCAINKLTPDPEQPNLNHESLSIRTRGMFSPYYEEVDPLSRRLSQGHGVSRPYHDSYPWVSSTSSSPLTATASVSSLSSVAPSQPSNPYHRHSIATQPFIFASEAEGHGNRKPYRSEKDIRHCDAEKARRDHQATYIDMGHSLRCEFPLDEEDASGDEAELTSELDQGHPNKRKTKEKTTKQHKLHNQVLWEFRACLRIDTNKVRKWLDRVKSQGEELKRRKYELKEGQGRGGLREGERERDRDRCVKAEAVMAMWDLMDREYWKFVAKHEESQDAQGQELEPIPGNRKRCLERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZ32</accession>
    <name>A0A3D8SZ32_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bacteriophage T5 Orf172 DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_02193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZ32"/>
    <dbReference type="OrthoDB" id="3511049at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053006">
        <property type="entry name" value="Meiosis_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018306">
        <property type="entry name" value="Phage_T5_Orf172_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 113 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094:SF1">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 113 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10544">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00974">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacteriophage T5 Orf172 DNA-binding" evidence="2">
        <location>
            <begin position="555"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="399"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW91028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="723" mass="80671" checksum="2C753C30AC152FD1" modified="2019-01-16" version="1">MLDHPPTHKGIIPALTDPSEASKPRLCRNVQSFQDKIDELRNLKTDSIRCGAIPSHGQCRKETPIRDSEVLRNLDQLDISDSETRLKLIMLMLCDTHWAKAIYTLALFLDSESLCNLKLNTERVEDTITDYESSIAIDGKHLTSKSLHPPGNNKGRGTVYVAATNKHDVQDGIQTIKREEVHTSSSTSKSTEAFYKNAEESISEPPVVAGMGSFASLELGVAKLEILNRESLNCIAMTTNGWRCKNIIDPDQLLKARELLRSSVSTGSSVDFNILSSLVLCSNHQRTTLPEKYSEKWATFSAQRLSKDEAISRFNPDKWNVVQFFGNQESEKTARSKGSESPGLPSRVSTPRSRQTTPSNSFLRPESSQPPNCNFSARRHSFNMESTIPSISDRLRELNYSQSPSPAPLGTRLFNPKPPISLKPSVSVPELVEDPFNDNGPKHTGALSSGLSKNASCSVPIKSEVPPNSGLAIRTPQSSSGVPHVSGVFVEELDHPGERNTPQSAQCTKTRKISLFKGASPQSAPTMYPGAIDDKLTDEIRLPVSRKGYVYIFKSAHLKQVKIGRTTDVNRRINEIKIACQISDLETVDCSYVKYPERVEKLAHLELQNFRAAANCHHNKGTISGAVVHREWFDVPDEVAVKSVELWKAFVELAYGRHGTIKEHWAEMLENLPRPSSSETKSLRKGIAEKNTDEIALHHHLRHERYTKWFEDGQLWEENCGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZG9</accession>
    <name>A0A3D8SZG9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZG9"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046536">
        <property type="entry name" value="DUF6601"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34414">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34414:SF1">
        <property type="entry name" value="SUBTILISIN-LIKE SERINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20246">
        <property type="entry name" value="DUF6601"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="312" mass="35093" checksum="736BDA6283E18139" modified="2019-01-16" version="1">MVAPDYIVPFGTHETIDTEQLDGTDPIRTADEVVATRDRYTAAFCQEQLDAIYSHLWSAGSKGNISPLHHQKVLCRTIILTERPDLHLVWFSRIIYIQPLPNTLLNEHFFTTVVLPSPSLYSTVVGFLYSYTKLIAHESDLTLAHELHLVNKAVTWKAWVDFRTAIVRSLGSGAVKPVQIHRRYDYGELRLARLNYIYRLTFRGVTYFTTHREYATYFTEYLTTGITVFAFVTVALTAMQVIVGIEGISQALVETMYRFSIAVLIVVAGFSAAVGVLFGVLFVFNTGLAIAEAFPVRRGGENGNQRGLHVPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZJ0</accession>
    <name>A0A3D8SZJ0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_02897</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZJ0"/>
    <dbReference type="OrthoDB" id="4060227at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="30"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW91732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="694" mass="77300" checksum="1F89842BE763D8BF" modified="2019-01-16" version="1">MNRNKRPRVDSDAAAAEDHLPASKPQLTRACAECKKHKIKCLVQPGQDTCNKCLKSGIRCVPHSLAQRFIDKDTDWKSHATSTMEQLKRAVGHLLQHNNLSDLSSYKVSTSICPRPAEVPAGPISPSTMDHSNVRTIGNFISEGPSIQQQENDSDLVPLPMNNLYSLTNPGNSRLIRVDPSLVNGPDFISRGVIPLAEAEFLFDHFRCYINPLLWDGILCVHKTLSQARESSSLLVATMLTVAALHIPNREQSLRATYDAFVSLMRASCMLRSQNLDDVRGLCIGAFYLTSLSWALCTRAVRVATEMNLHKSSLQFARGSLESYERVRLWYILYVCDHQFALAYGRPPMMHDDVAIRNADKLLASGLSSEGDRGLVAQVKLFRILARCYFMYGCDADLELGGQDFEILQSLNISLDQWRLEHQPRGTDSTRNTLVSPKAITLYYHLARFQLNSLSLRGISARRAATSPDMNWDRQEAANNAIAAATSTVRLMIEDSDLRSAQIGMPIFVHAMVAVCASFLLKMAVVFSEPNIRNGNTLYLPEDLSKYGLTFHTKNILTEAERLVRMLNEVADNASQQHVARHVVTGLRELLQRFSPGAEMDSFVYSRSSGMPSLLESSVANQSISKGYDAYAMEQADSSGFNQSYLNIPAGQGNKAAQPASHEQQQDPFDLLGDLDWRFNDAFLLNIQADETYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZP7</accession>
    <name>A0A3D8SZP7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_01197</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZP7"/>
    <dbReference type="OrthoDB" id="73348at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1050.10">
        <property type="entry name" value="At2g23090-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045230">
        <property type="entry name" value="MBS1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026939">
        <property type="entry name" value="ZNF706/At2g23090_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21213">
        <property type="entry name" value="GEO09665P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21213:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN 706"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118359">
        <property type="entry name" value="Expressed protein At2g23090/F21P24.15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="11"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW91803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="78" mass="8667" checksum="7A9D154E689F6798" modified="2019-01-16" version="1">MARGLQKIEAQQKAAANAKKGGNSILKKDKGMKYQCSTCKADIDNKNNMKIHWEAKHPKLPAPTDEFASMERTPPAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZV5</accession>
    <name>A0A3D8SZV5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_01236</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZV5"/>
    <dbReference type="OrthoDB" id="4200124at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="19"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="841"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="500"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="862"/>
            <end position="876"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW91842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="912" mass="101244" checksum="5EF6FF30B86F4BA0" modified="2019-01-16" version="1">MADPGNMQPAQSPQSKKHALHLHDLPKETQQTIFSFVSCADLVSLCLVSKRTRDLATQRLYQAFHIVFPDDDDPSNDSQIDGLAAGLDTLATSDYNYAQHLKEIALYAFSGGEKGERAYTWDIRVELGRQVFKALHQIPSLTNVHIRMHAGPSLYEPPPAIRSKATSLDPKEASKPASRFGAVDQLFDWHEYDERAVDTRSIVINPSTLFPSGISFVMNQPKRSANGLTLDPPTISGFRNLKKLSILDMDTLDYITELKTCLRNSSHTLSKLELSFSTNLANQARKPPAETSDDDDSDQDADDFGGTNDDVSGPAQAFRAQEERKLQEGFLGQIFGSFDIPQNKADRVPEKPKSESRAHSKAATNIKMQQILELFTKTMQEAKSAIGLQDHQDLEGVITKVIDEINKSIDKNVESHFREAQSEMVALEIESETEPVGSQETQNTSGSAPSPPVDSAFPTTTEEEPSLAEIKVDEPEGDLVIEEGDQLIAPAETAETISDPSEKQPERERPPSPKPNEILKKGSIQYGQTKKLVMDLKSMVASGHPLLDGEGCRYSVEDLDRIHSELCSVEGALGQPQSESSALDNKKDRLRSSEQVATREYIRKTRGLSLTELSIFLIPIKASVFSKAINLSVLQSITLLNVGAQAPFWTMLKKENDIKPLGLHKIHTDNVTSTFLTFVSQLEKVTELYLLERKINSKVESFAAKTITTITSIRRLALKKHAGTLKVLRISNDSSYAWDVDAKTIALLCQKAKKMEELAMSLNVRVMHNFLQALSGLASLRALHFLHLRTDDLCMWVVREARKFTIDTISQIPSCKIEYVALEKGLERLIRCKPQAKAKTISKKKSKKAVPNLDPIPGFPIPEEESVGESESDGDDDKLTQPQLRIESSEGMPFHDAVDVKIFKNGIMFGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0C2</accession>
    <name>A0A3D8T0C2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_01409</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0C2"/>
    <dbReference type="OrthoDB" id="5333304at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="379"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="119"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="63"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="454"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="494"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW92015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="862" mass="96874" checksum="87829FF688D07DC1" modified="2019-01-16" version="1">MAQGAVAFLPANAATLTPDELHEIRECQKICAFRDAVLAGTHPRIKVPSHPVNVSKLSSAGHVPGATTPAAHTHAVSSSNTETPSLFSRTKNATAQQNSTLPVKPAKSEINPILLEKSEDLIKAEIQLQRQRLERALREQIEQQRLAQKAAYQSSESLPNFDLTEVLTKALAIVHPSAIVEAAPSVGAASDSFDDNTFYSSQHDTPNLSSSPHGKDQKESGEVQSHAIVSADESSGTGSASQSRANNREMVATGNSRSNDNVETAQHFSSSHQLTHNIHTTDNSLMVDARNNITDVYTTPDESSHVLKLRDTQKSTNSLLKEAFAIDSTSPLVRGHDLSPVAPQPARVSPLALAREPPIAHQLHPDEAPPAQVAALREKISENSSTDSSPKGSRSERKKRKEKKQKRKSAVVNTPDSPYIKPEPRSPSPYGVTPLPRPNKRPRVSAYGTELNYDEPRHDEPSASHGERTVPRREIVPYESYGEPRRVPPPTYERVGRDEDNYRRRVSEGQYIRRLSPQAPQGHDLYGQPEATSARPVSHAVVDRRIDEPARYYRDLPPRASVRPDVDRDRSRSPIMRERASPIPMGPPRHPVRIVVDEYGREYIDQTPVRQAMAPTARREIYYERAPTRAVSSRAPVETFEENGVIYRRASPIAMAPRRVVTQPEYNDPEYRQYRQREYSVRPMGPPSEEIVRQREYSVRPSMAPPADDYLRQREYSVRPMAPPGEEYIPKRAPIRREATYLEEVPPREYIRAPSVRPETVRYELPREYVGRLQSVRPEVPGREYTGSVRPEALREVAIPPQREYSVRPVERPRREYIMDAGDRYYEGGREAERVTYMERPAPEAGDVVYAGDGIRREVYRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0J2</accession>
    <name>A0A3D8T0J2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Lysophospholipase</fullName>
            <ecNumber evidence="6">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_01434</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the lysophospholipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="6"/>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0J2"/>
    <dbReference type="OrthoDB" id="6121437at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00147">
        <property type="entry name" value="cPLA2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF40">
        <property type="entry name" value="PATATIN FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5 6" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4 5 6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLA2c" evidence="8">
        <location>
            <begin position="234"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="660"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="677"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="692"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="716"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW92040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="872" mass="97526" checksum="827CEA79B7B9E0F2" modified="2019-01-16" version="1">MAHQPGLLLPNMLHSPSRGGSVLRFLCSSSLRPPQRYQVQRPRTSCYSGSWHKQVYNRNCGVRDLSTRSSTEHPQTKMASTARSTLVAATTIVITGSLFYILYRNDFVQPLPPTKPRSLVRAQRQKQEAVEEKQAELAAENAQELSHLPFQNPATTEHQDDSAWGVFSARFATFSALTDIQWNALTETISDYIMPEWVKVLPGYINKLQQELTMAPGSLASEIWQEAHDPYINPEIEYSASVRISGDLCDEEKEFLVKRKNHTRKALAVYLGLPEEEVHPDDVPCIAMVGSGGGLRALVAGTGSMLAASQDGLFDCVTYTAGVSGSCWLQSLYHSSLGRQRFDQLVNHLKARIGIHIAYPPVALSALNSAPTNKFLLSGFVEKLKGDPNAEFGLVDVYGLLLAARLLVPKGEVGVDNRDLKISNQRESIKYGEHPMPIYTAVRHEIPVEEEASDVEKQMDTPSEETKERAKKEAYFQWYEISPYEFFCEEFGAGIPTWALGRKWEKGVNIPYEDGLYVPEYRLPLLLGVFGSAFCATLSHYYKEIRPIVKGLAGFGGIDDMIEERNEDLSKVHPIEPASFPNFAYGMEGQLPETTPETIYKAKHLQLMDAGMSNNLPIYPLLRPGREVDILIAFDASADIKTENWLSVADGYAKQRGIKGWPIGSGWPKGSDTAEKTAGQLDAAQAATASEAEDKVMAAKQHQADHPVKDAHEGHSQNSNGNSDQQQNGDLGYCTIWVGTTEERTTDLEEDQTPQSKTVEEDWQLMEPDAGIAVVYFPFMKNPKVEGVDPVTSDYMSTWNFVYTPEDIDNVVALAQANFDEGKERTRRCVRAVYERKKRIREEREKTEKYERFRRKMRMGAVGKKGEGDHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0P3</accession>
    <name>A0A3D8T0P3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Vacuolar calcium ion transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_01484</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Vacuole membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0P3"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000026">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1420.30:FF:000027">
        <property type="entry name" value="Vacuolar calcium ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004798">
        <property type="entry name" value="CAX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00378">
        <property type="entry name" value="cax"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF14">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0050">Antiport</keyword>
    <keyword evidence="6 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 10" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <keyword evidence="10" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="98"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="381"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="441"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="120"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="12">
        <location>
            <begin position="317"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW92090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="483" mass="52856" checksum="3E67344CE5619362" modified="2019-01-16" version="1">MGLFERRSEERRQDSMSRKDDVEMTTSASASASLGDPRSPAAAHTKSKKGHHHLPIYNHKGHKVTPGIQPDGESGRRGIHPLHFFKIVWASSSDASRLVNILWPVVPAAIAVRYALPDHQLLIFILNYIAMVPCANLIGFAGQELARKMRKVFGVLTETTLGSVVEIILFMVLLSRDKIQVIQAAILGSILATQLLCLGLCFFVGGLTMDEQEFDSAVSEVGGGLLLVAGFGLMIPAVFKVANQGKTNVTTAVIDAKVLDMSHITAILLIVAYFTYLWFQARTHHGIYDAIFERDEERDADRQRDLDKNKLTLTECIIALAVSITLVTYIAIALVEQIDYMVETHGISDSFIGLILIPLVEKAAEHLTAVDEAYDNQMNFALSHVLGATIQTALFNAPLAVIVGWGLGKEMSFAFEIFDVVVLILAILVVGRFLDDQKSNYLEGALCVIVYMIIAVAAFFYPNPIIDTATGTIVERSIEALAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T2I2</accession>
    <name>A0A3D8T2I2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_01602</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T2I2"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW92208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="122" mass="13907" checksum="28AB268859B21614" modified="2019-01-16" version="1">MKYKTLSQDANSDENIAASENISHDRESKAIERTATRRLMWAILVNIFLTLLLLVSLGFHLYRPATNIDSGFKAQYGRNYDYMTLDHEFDHLWMDPAVETGGMIVMSKDEQGKPTEYGAIAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T2T2</accession>
    <name>A0A3D8T2T2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Glucose oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_01702</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T2T2"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.450.10">
        <property type="entry name" value="Glucose Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027424">
        <property type="entry name" value="Glucose_Oxidase_domain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017584328" evidence="9">
        <location>
            <begin position="19"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="10">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="11">
        <location>
            <begin position="293"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="526"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="569"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="32"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW92308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="589" mass="62586" checksum="E3C0A170C67D2F85" modified="2019-01-16" version="1">MLRTLSTLALATAAAARATPVSYDYVIVGAGTSGLVIANRLSELSNVTVAVIEAGDSVYDNVNVSSTTGYGLAFGTAIDWAYQTTNQSFGGDIVQTMRAGKAIGGTSTINGMAYTRAEDIQIDAWEALGNVGWSWEVLFPYYKKSQQLQIPTEAQAAAGVTYDAADNGFEGPLKVGWNPALNVGDVHTVLNETYAALGVQWSEDVNSGRMVGYNRYPSHIDVALNIREDAGRAYYYPIANRTNLHLYPNTLAHRMTWDTTAQIPTANGVVVQAVNSTTPYTISANKEVILSAGALASPLLLELSGVGNPAILSKYNISTVVDLPTVGENLQDQTNTGLAIDTAGNTSYSGTSDYVAYPTAADIFGSEITNISATVLAALPSYAATVAAASGNVTKASDLLSFFKIQHELIFSTTHPVPIAEVLLTPSGTAVDCEYWALLPFARGNIHITSATAGVPAAINPNYYMLDWDVTGQIQVAKFIREIFATQPFAGLLGTETKPGFDVVPQNATNAQWQAWNNGVYRSNFHPVATAAMMPKEVGGVVDTSLKVYGTANVRVIDASVLPFQVCGHLVSTLYAVAERAADLIKSEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T378</accession>
    <name>A0A3D8T378_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_01842</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T378"/>
    <dbReference type="OrthoDB" id="5350396at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46201:SF9">
        <property type="entry name" value="PHD FINGER PROTEIN MALE MEIOCYTE DEATH 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46201">
        <property type="entry name" value="PHD FINGER PROTEIN MALE MEIOCYTE DEATH 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="351"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="29"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="165"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="320"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="76"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="194"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="331"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW92448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="824" mass="91205" checksum="F9380EB7BAF39B67" modified="2019-01-16" version="1">MEVKLRWTSRPEKCTLDAVFGSTQGWTATHTLGMSQKKSIKDFFKPPSKTPTTSKQSTKSNATSSRPPSTSATGSKATLSGGTLMSQKNVRSPTTSQSQVEQPHQPSFTSLSSAPSSLHTVLAFSDGQELAMSPSSDTAAVPLEALEIAPDVPVIARPEMVIKDSDDEDSDLDSDDELPDFLGQLQSKSGAANTRSMSRPRTPPRTARAHKLASFHSPLTVQSKKMFDFNSLIQEAKIDDATEASSKRLKALLSDSKKSGDDPAIGQDDVGIDNVMKKGELLDLLTEDLDEEEAQKRKEVLKKSQGGTAEKRWYFFDTKSRPSSSDSEAGNLRSNRASSTSRSATLESEGFLDCLCGEHGKIDDGSHSISCDKCNRWQHSECVGVNEVDAGNPEFSFLCRDCMVQKTPPDRTAFPLAAVTESWKAGLTVPEVRRHTLVSGMAENMVTLGRTLPDEILSWMLDELCFEKDALLREVYVGILVKSPSQVHRLINDEAVQDLFRKLGGTTRTTSLAHKILPVKELTSPYPYHDWANLRSIVKLLGRLSGLLSQQTRQYVINMLLRLGADTVLLHNVDLIHIAHNAMTAFCEAASEPEWEICVGLISLKRPGLLANIKRQCPQICSSVFTSIEHINIRLQVIKCIPSMTQRTRDIKRRLATACFFGDISYCHKDIYVHNDINKYTNHLTSAQEFKIGRKTDFHEVAARISLLDIAVNDGQHAGFDLSSKQVVELHNEDIVFLGRRIKAIYQAIPTDISATLDRRIEAKIAMEVVAYRIQSLTLNRPKPKTYRLVGKEDFEQERSGMSSFLKKRPNLLGVGTPIDNANS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7R2</accession>
    <name>A0A3D8T7R2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_00349</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7R2"/>
    <dbReference type="OrthoDB" id="5415072at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031632">
        <property type="entry name" value="SVIP"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15811">
        <property type="entry name" value="SVIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="1" id="KW-0519">Myristate</keyword>
    <keyword evidence="2" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW94586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="134" mass="13801" checksum="1B55F91BA8B0A177" modified="2019-01-16" version="1">MGNLCGKQSDDPFSQPGRTVGAAPPPSNNRTSTIPTGAKPNAPAAGGRKVGGPPRTLGGAGESTSSDAQKEDARKKAAAAAEARAKEASKTTGKLGGKLAEQKRQSRVGTLDALSKDERRTREVDAAQESRNYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8E4</accession>
    <name>A0A3D8T8E4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative nuclear protein SNF4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_00560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase gamma subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8E4"/>
    <dbReference type="OrthoDB" id="286637at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04618">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04641">
        <property type="entry name" value="CBS_euAMPK_gamma-like_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050511">
        <property type="entry name" value="AMPK_gamma/SDS23_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE, GAMMA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13780:SF35">
        <property type="entry name" value="LD22662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0129">CBS domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="166"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="241"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="6">
        <location>
            <begin position="309"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW94797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="374" mass="41916" checksum="22C8FA4A2AE9E52C" modified="2019-01-16" version="1">MSDAAAPEGIRPPALQPADHGNSSPISYGHEPPLVAQPSTFLLPRGHNRAMEDKPLSPLDRDQMHGLKSIRDFLRVRTSYDVLPLSFRLIILNTELLVKKSLNILLQNGIVSAPLWDSQTSTFAGLLTTSDYINVIQYYFQNPDALSKIDQFRLSSLRDIEKAIGVLPIETVSVNPTRPLYEACRQMLKTRARRIPLVDIDEETQREMVVSVITQYRILKFIAVNVDETEMLKKSVKDIGLGTYGDLQTATMDTTVMDVIHIMVKHSISSVPILDEKKKVINVFEAVDVITIIKGGVYDELGASVGDALSKRSENFAGIYTCSEEDRLDSIFDTIRKSRVHRLVVIDEDHHLKGVISLSDILQYVLLHGEDDDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9E0</accession>
    <name>A0A3D8T9E0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative opsin-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_00900</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal/bacterial/fungal opsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9E0"/>
    <dbReference type="OrthoDB" id="10261467at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15028">
        <property type="entry name" value="7tm_Opsin-1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001425">
        <property type="entry name" value="Arc/bac/fun_rhodopsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018229">
        <property type="entry name" value="Rhodopsin_retinal_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286:SF2">
        <property type="entry name" value="BACTERIORHODOPSIN _OPSIN, NOPA (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01036">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01021">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00950">
        <property type="entry name" value="BACTERIAL_OPSIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00327">
        <property type="entry name" value="BACTERIAL_OPSIN_RET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="213"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW95137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="332" mass="36061" checksum="7554933733892CB2" modified="2019-01-16" version="1">MMVDPVEALLKKTSSLLVPTSSATHTVSPIPTVVPGPSRVFEKVGGSGATTLWVVFVIMLLSTLAFIWMAFKVPVQKRVFHVLTALITTFATLSYFAMATGAGGEHYSAAGIYMVSIPLHVVVSNETSSVSFAHTVIRESHKHTGVDTVTHVFRQVFWARYIDWSLTTPLLLLDLAFLAGMNGASILVVVVADVIMVLLGLFAAFGKSDAQKWGWYGMACLAYLVIVYQLVVSGRRAAMTKDNSTSKLFASIGGFTLILWTLYPIVWGIGDGARKMGVDAEIICYAVLDVLAKPVFGFWLLFAHTKNVTNIEGFWSRGLGGEGSVRLEDDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9I5</accession>
    <name>A0A3D8T9I5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial</fullName>
            <ecNumber evidence="10">6.2.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Succinyl-CoA synthetase beta chain</fullName>
            <shortName evidence="10">SCS-beta</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_01002</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>succinate + ATP + CoA = succinyl-CoA + ADP + phosphate</text>
            <dbReference type="Rhea" id="RHEA:17661"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.2.1.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10 12">Belongs to the succinate/malate CoA ligase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.5" evidence="10"/>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9I5"/>
    <dbReference type="OrthoDB" id="1552at2759"/>
    <dbReference type="UniPathway" id="UPA00223">
        <property type="reaction ID" value="UER00999"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042709">
        <property type="term" value="C:succinate-CoA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004775">
        <property type="term" value="F:succinate-CoA ligase (ADP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006104">
        <property type="term" value="P:succinyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000002">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000001">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000004">
        <property type="entry name" value="Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00558">
        <property type="entry name" value="Succ_CoA_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013650">
        <property type="entry name" value="ATP-grasp_succ-CoA_synth-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005809">
        <property type="entry name" value="Succ_CoA_ligase-like_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001913">
        <property type="entry name" value="PRK00696.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01016">
        <property type="entry name" value="sucCoAbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815:SF1">
        <property type="entry name" value="SUCCINATE--COA LIGASE [ADP-FORMING] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11815">
        <property type="entry name" value="SUCCINYL-COA SYNTHETASE BETA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08442">
        <property type="entry name" value="ATP-grasp_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001554">
        <property type="entry name" value="SucCS_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52210">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 10" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="ATP-grasp" evidence="13">
        <location>
            <begin position="42"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="86"/>
            <end position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="361"/>
            <end position="363"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared with subunit alpha</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00063570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW95239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="444" mass="47642" checksum="08B07FE7E9220C20" modified="2019-01-16" version="1">MFKLARSRPFTAAFKAAHVSPSRLAGVAQQKRALSIHEYLSADLLRQYGVGVPAGQVAKTAEEAEAVAKKIGGDDMVIKAQVLAGGRGKGTFDNGLKGGVRVIYSPTEAKMFAEQMIGHKLVTKQTGAQGRLCNSVYICERKFARREFYLAILMDRATQGPVIVSSSQGGMDIETVAKESPEAIITTQVDIHKGVTDEMAIKIATDLGFSEQCIQDAKDVIQKLYKLFMEKDATQIEINPLSETSDHQVLAMDAKLGFDDNAEFRQKDIFALRDTTQEDADEVRAAESGLNFIKLGGDIGCLVNGAGLAMATMDIIKLNGGEPANFLDVGGGATPAAIKEAFTLITSDPKVTAIFVNIFGGIVRCDAIAQGLISTVQSMNLTIPIIARLQGTNMEAAHKLINEAGLKIFSIDDLQSAAEKSVQFSKVVKMARDMDANVSFSLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q3T3</accession>
    <name>A0A3D8Q3T3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_13150</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000026">
        <property type="protein sequence ID" value="RDW56509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q3T3"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd08760">
        <property type="entry name" value="Cyt_b561_FRRS1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006593">
        <property type="entry name" value="Cyt_b561/ferric_Rdtase_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018825">
        <property type="entry name" value="DUF2427"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797:SF1">
        <property type="entry name" value="CYTOCHROME B561 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47797">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G05805)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10348">
        <property type="entry name" value="DUF2427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00665">
        <property type="entry name" value="B561"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0249">Electron transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017699251" description="Cytochrome b561 domain-containing protein" evidence="9">
        <location>
            <begin position="33"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="165"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Cytochrome b561" evidence="10">
        <location>
            <begin position="100"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW56509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="299" mass="31499" checksum="89198AD908D31CC1" modified="2019-01-16" version="1">MSAFSQILGTGSLAPRSLVLGLTCLNYGVVAADPSPSPGRFDYPRRSALLPSTALAKRADTASDPADSGFLGLLSGIGNNGGAGSTRANRVGGGGKASIAHGAVMIVAVLILFPIGVLSMRLLKRWYIHAALQGIALVFFLIGVFLGINIGTAKNKLFNNAHTNLGIFLTSLLLILQPLLGMFHHRSHEKFGYRGLVGNIHRYLGHALLLLSVINGGLGIQLAGQTGALKNAYIVLAVLMGIVYLYVILGKVIKGVFKKVSLKDEPKPASEPETTSAKDKGKEVAAEETATIKKKGIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q3Z9</accession>
    <name>A0A3D8Q3Z9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF4387 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_13179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000027">
        <property type="protein sequence ID" value="RDW56430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q3Z9"/>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025496">
        <property type="entry name" value="DUF4387"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14330">
        <property type="entry name" value="DUF4387"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4387" evidence="2">
        <location>
            <begin position="183"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW56430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="261" mass="28185" checksum="B4C4F7271BEB8738" modified="2019-01-16" version="1">MFMGGIRDPILICQMDAVLERVQAYVAHVTSNFEGQYEVGFHVYGNDGIRGTLEPDNASYVPREIFIVGEVMANTQEIATIIASTARVACVHGSYPEQRGTGGSFVMGIGDGTEGACQISGPVEQSSGLRLFSWTMQQIGEAKPKPSVNGHESTGTLSATKQAPAQSFTKHQKFSFNSCLLTLADIAPVIRSTNSGPYDITFDVIFSSLPVYGIVKSSNLLSKSLIGKLYKLRGDEIIWCGFSNQAMAFKATIPRKRLVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q405</accession>
    <name>A0A3D8Q405_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_13060</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000025">
        <property type="protein sequence ID" value="RDW56595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q405"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031389">
        <property type="term" value="C:Rad17 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000028">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000004">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000129">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF9">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="77"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00070184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW56595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="396" mass="43289" checksum="E65C675374843CC2" modified="2019-01-16" version="1">MSDYEDDMDVDAPAPASTIMFSSDNTNSKGKRSAANLPVEAEDSLPWVEKYRPDTLEDVSGHQDILATINKFVDTNRLPHLLLYGPPGTGKTSTILALARRIYGSKNMRQMVLELNASDDRGIDVVREQIKTFASTKQIFTMAPTANSGSSMASYKLIILDEADAMTSTAQMALRRIMEKYTANTRFCIIANYTHKLSPALLSRCTRFRFSPLKEKDIRVLVDKVISEENVHIDSAATDALVRLSKGDMRRALNVLQACHASSTPLHIKGTPKVLEKDIVRDLITETTIYECIASPHPSDILKIMNTLLKTTDVTSCLQMVNSLKATQGLALADIITALSEELSKLDVPAPVMITWLDGLAEVEYRLSGGGGEVVQTGAVVGVVRNGVELMGNVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q4N9</accession>
    <name>A0A3D8Q4N9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_12856</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000024">
        <property type="protein sequence ID" value="RDW56789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q4N9"/>
    <dbReference type="OrthoDB" id="10453327at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW56789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="257" mass="27500" checksum="4569978967E9BED8" modified="2019-01-16" version="1">MDLFPRRIPSRDTMLDAEWARKAVSTGDLQKGSKGKRDGCDADNDDDNDDVNSTCSQSIITSITSTATPTATSAVKSICVDDDDDDDDDDCTSTSTTMHVKSTILSTPSGAPTALSAASLGISSVQTTQGQNGTIAIVIILVGIVFVLPAAILIGRKFWKRRQSATTEFQEEPSNAGQSLNQGVANIGIAESEVVVASRPELTQAREDPFADPKETINNGVNVNGEEYGSLASRFERHLEEYHVNDTEIILCFEPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q523</accession>
    <name>A0A3D8Q523_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_12854</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000024">
        <property type="protein sequence ID" value="RDW56787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q523"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF3">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="217"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW56787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="388" mass="43442" checksum="CA918E94FC418B23" modified="2019-01-16" version="1">MATGHGPAPPLPALSPQLPQTSALPRTSGSEQPESHYSSSVPASFSHEVKSAVDVRLGYPSSGRISLFPMIDAPLFGSPCQIPATDSKAPHTDNVLPPRKHADVLMDIYWRQIEPLEPFLEKESFSRSYQALFDGTLADDEERLLLSALNTIFALSTQWQESLPREQREEVSGTYFGRAWALLRPEAIIWGPPSLDLVQCLLLMARYLQCTNRSHQTWMAIGSAVRIAQSLGLHHKPDLSSSDSACESWRRRQLWQYCVIMDRAISWVLGRIPMAPPTVSSFFIDPVLNHGIRGPSHAPPSHYVAKIIDLYEMSNHIMLLQAPASNSSVDRLGLPRLYQDNEYLSTAVQIDACLNKWERGLSQPLRSDADQRNTEDISYTQGVYLRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q5F0</accession>
    <name>A0A3D8Q5F0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_13099</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000025">
        <property type="protein sequence ID" value="RDW56634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q5F0"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF697">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="50"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW56634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="473" mass="50668" checksum="DF1B21B1C1D6D902" modified="2019-01-16" version="1">MGVPITEKPLEATVVEPRGSSIVEGEVVDANTLEEREVFKSTVDGVDFRTVTWQRAILIFLKVQIATGVLGIPGAFGTLGAVGGVLSVIAWQALNTYTAILLADFRNRHPECHTLVDECGIIWGRLGREIAGILFLINYVLCTGSGILGISTALNALSNHGACTVWFSFVGFIMITMFSSIRTWGKMTWPLTLAFVSVIAGVLVVVIGVSFQDRPAAAPQTGPFDLGFHVITYPDFIAGITASATIFVSSAAGPNYVSVIAEMKRPQDYRKAVYPVGFIVGAVYLSFSMVIYYYCGTWIATPSLGSAGPLLKKVAYGIAFPSLIVSAGLFNHNSSKYAFVRILRGTKHLQSNSPIHWSTWIACNLVAGFASFIICSAVPVFNDLLALIGSFCGAPMSIIIPASLWLYDFNHYRKGNLKQVIFYGIHLLLALLGVFVFIGGTYGTIVTIKASYTSGGGVGSAFSCADNSNTIAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q664</accession>
    <name>A0A3D8Q664_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dipeptidyl-peptidase V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_12971</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000024">
        <property type="protein sequence ID" value="RDW56904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q664"/>
    <dbReference type="OrthoDB" id="43744at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="WD40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776:SF27">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE FAMILY MEMBER 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="5">
        <location>
            <begin position="411"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW56904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="624" mass="69411" checksum="04626BCB4929F8FC" modified="2019-01-16" version="1">MDLIGDVLDLIVPTRLTLSPDGKSVAYSTRLKWNHKKDDYICPSIWMAETGLQKSARRLTDGLFNDKMPQWSPSSEVIAFVSDRGKQGRANAIYLLPLGTNTPRAITPAENEQQILKFKFSPDGKQIAFICAPENIQKATIVSLFNKNAHVTDFDWSDSGTEIAFTTLRTPHVESQYIHGTTLSIVRIEDRELRTVCHMPRGVSSLTWSGSVLYFITNNTPEHDTSGFAVYSVKLVDEESIYEKVADGEENCTVSLVRAGKEVLVHVEHGLEDQLRALNGHVLLSCKKRIVEIDAVYVRDRNDMVIAFTQGDVNNPTEVLSVTTAQETTQLSNHGSIFASQKFGECTFVQCPTIDGNELLNGIYLTPTSYAGLDDKPTIPLPTFVLLHGGPYTRMTNAFDVWDPLSFLIPSFLSEGYGILIPNYRGSSGKGERFASYARGGMGIYDEVDVVAMTQYAVQQGYADKNKLLAGGWSQGGYLAFLLSVRNGRHGFGWQFKGLIAGAGVTDWDSLVLASDVGYMQAQLAGGSPWSMDKSDTRTRAGSALWEFKDALEMGTIPPILIMHGEKDARVPISQAWGFRRALDEAGLPFEFVTYPREGHFFRERKHVEDLLKRMFRFVKEHIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q6A6</accession>
    <name>A0A3D8Q6A6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RmlC-like jelly roll fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q6A6"/>
    <dbReference type="OrthoDB" id="5793281at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02234">
        <property type="entry name" value="cupin_BLR7677-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38599">
        <property type="entry name" value="CUPIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G13620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38599:SF1">
        <property type="entry name" value="CUPIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G13620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="19"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW57385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="112" mass="12155" checksum="C90B76D73E9C471B" modified="2019-01-16" version="1">MFDYEIANAPGKSIIGLQVTLPPNGWTPPHRHGGAHVVAIVQEGELRSGMNGNPPQVYTSGQSFRELPGCHHTVADNNRKDESCRFMAIIVIDTEVVKKGGYGALTVLDEGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q7L6</accession>
    <name>A0A3D8Q7L6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_12590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q7L6"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF12">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW57789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="558" mass="63765" checksum="E7BC607017E52F8E" modified="2019-01-16" version="1">MEANVNPYVIDEHPFGEPRRLRVITIGAGASGLNVARAVGAFMKNIDLQLYEKSDDVGGTWLENRYPGCACDIPSHNYQYTWEPNPYWNKYYAPAAEILKYFQGVADKYNLRRYIKFQHQVVKAVWDEDKAVWNFKIRNLVTGEEVDDYCHFFINASGYLNNWKWPDIPGLHSFKGSLLHSAAWDPKIDLKEKTVAVLGCGSSGIQIVPSIQPVVKHLTTFIRTPTWITAGFASKMAAPGGNNFDYTREQKVAFAEDPEMYLKYRKDVEHELNSRFKMLHKDTPEQAAAIKFAEEDMRKRLGCNPQLADSIIPKFSLGCRRPTPGNGYLEALNCDNVRVVIDEINRIVEDGIILKTGELIKIDAFICATGFDVSFCPRFPIIGRKGIDLRTQWKDRATAYMSLTPENIPNYFMFMGPNSPVGHGSAPPIIEHLTKYMLKIIYKAQLENIKAMSPSPAAIQEFTEHSDIFLARMAWSSSCRSWFKNGSVDGPVTALHPGSRLHWFKMLEEPRYEDWEWTTWNKNRFAYLGNGFSTKESDGRDLTWYFDSPDAGYERLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q801</accession>
    <name>A0A3D8Q801_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_12628</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q801"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF6">
        <property type="entry name" value="OXIDASE USTYA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW57827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="243" mass="28508" checksum="B6F5C10EA6C8A9B0" modified="2019-01-16" version="1">MSKIEETSYMPVQDDSNEHLPLERQRKKRGSMFNFRQFLMLEGIHLTLILGVYALFLTAKYRTEYRTTMTKAHGLDTYFGLSEYNIIREFYGNANLTNKTAEADALFERIQNTDGIVALDTEWALQNGYAPSRLHPEDPTKSIYQIDMFHTLHCVYRIRNLLTSSLSLEQWLRNDDHTLHCLDYLREQLMCNPDLLLQGTEDYVHFNVNHGHTCRNSDMITDWAKSHHWSGHRQYLIDTVGIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q8Y5</accession>
    <name>A0A3D8Q8Y5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_12233</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q8Y5"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF213">
        <property type="entry name" value="DEHYDROGENASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017610322" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="385"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW58303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="683" mass="72986" checksum="C1435A3D7EE72BE4" modified="2019-01-16" version="1">MWTPLHLLTFAAVLCCVSAFSFPRHSHPKRVTSRTTSLPTSRTTSLPTKGTVLPTYDYIVVGSGPGGGPVAANLAIAGYKVLLIDAGDDHGTTYEYQVPALQLQSTEDERTRWDYFVNHYPDLTRAKKDSKMTYRLADGSKYVGLHPPAGAVPLGILYPRAGALGGCAVHNAMITIYPHDSDWTNIQTLTGDASWSPTNMRNHFIKLERCGYLPNGARGHGFNGWLGTALTDLSLVVQDPKLLSVILSAATAAGKHVLGLLLNTVLGLAGVLLQDINAPGQSSIPGVYQVPLATIGGARNSPREYILRTANAVNPDGSKKYHLDIQLNTLVTKVRFVKIGTTPVAVGVDFLRGQSLYRADPRSGSATPSGSGSVNATREVILSAGAFNTPQLLKLSGIGPAAELTRFNIPVLVNLPGVGTNLQDRYETTVISKSTSDFVVTRDCTFLSKLPDPCLTRWVRGNTASAKGIYAASGVAVAVVLRSSVAEGEPDVLVSGAPVQFTGYYPGYSKAAEVDARHWVWITLKAHSRNNAGRVTLRSANPLDTPVINFNSFDAGTGSAIKDLQAMYEGMQYSRAAFKDLIPLDGSFAETWPGTNVSSESNVKQFILDEAWGHHASCTCPIGADNDPMAVLDSSFRVRGTKGLRVVDASVFPKIPGFYVSLPVYIISQKASEVIIADAVKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q906</accession>
    <name>A0A3D8Q906_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NmrA-like family domain-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_12245</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Perinuclear region</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q906"/>
    <dbReference type="OrthoDB" id="3358371at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000181">
        <property type="entry name" value="NmrA-like family domain-containing protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF31">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="8">
        <location>
            <begin position="5"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW58315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="319" mass="35071" checksum="10C39C26542D7A82" modified="2019-01-16" version="1">MSSNKKIIVVIGATGGQGGSVVNTVLTDPKLNATWAVRGVTRDASKGSAKKLESQGAEVVEADVNSKDSLMNAFQGAYAVFAVTNYWEKLDMELEIQQGKNLADAAIATGIQHFIWSSLKNVTEITKGALPNVYHFDSKAKVEEYIRSTSLPATYMMPGFYMSNFPGRNLRPSPPDNAWTLAMPLPATATVPLIATIEDTGKFVSAILLNREATLGKRVLAATEYYSLEELLQDFKDVYAEAGKTARYYEVPHEVYKGVLLNAGLPEFGAQELLENMRLLNEGGYYGGESLEWSHSLLHDKLTTWKEFIKTAPAFKDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q984</accession>
    <name>A0A3D8Q984_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q984"/>
    <dbReference type="OrthoDB" id="1577640at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009116">
        <property type="term" value="P:nucleoside metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1580">
        <property type="entry name" value="Nucleoside phosphorylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053137">
        <property type="entry name" value="NLR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035994">
        <property type="entry name" value="Nucleoside_phosphorylase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082:SF11">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46082">
        <property type="entry name" value="ATP/GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53167">
        <property type="entry name" value="Purine and uridine phosphorylases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="333"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW58386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="378" mass="40973" checksum="D9A5B18FDF71E2BB" modified="2019-01-16" version="1">MLVKATKNGHQSVRTLRPEEYTVGWLCALPASELPAAIHSLDEHHDDPELKLPDTNTYSYGSINRHNVVIACMPPSSPGKVSASGLIPTMRLNFPNIKIYLFVGIGGGVPNKFFDPDPENDIHLGDVVVGWPDKVGAPAVVQYDLGRNREDGFEITSYLDGPEPSLQSALGKLLANRVVGRTRFDDWLQQTAEQNPRFAHPGVAEDKLFKATYPHGQAPDCSNCPSAGYAHRPKRVDTKLIFHQGTIASGDSVMKNALERDRISALCGGARCFEMEAAGVMNQVRPLIIRGISDYADGHKNGKWHNYAAAAAASFAKEFLYTISPVIVGGLEPVKQSDNGQRDTKSSQENHFTGTFSTNGGKMMIGGTYNSGGGSMSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q9M4</accession>
    <name>A0A3D8Q9M4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">L-serine ammonia-lyase</fullName>
            <ecNumber evidence="5">4.3.1.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_12300</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-serine = pyruvate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:19169"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="EC" id="4.3.1.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the serine/threonine dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.1.17" evidence="5"/>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q9M4"/>
    <dbReference type="OrthoDB" id="7773036at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003941">
        <property type="term" value="F:L-serine ammonia-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004794">
        <property type="term" value="F:threonine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006565">
        <property type="term" value="P:L-serine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006567">
        <property type="term" value="P:L-threonine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000040">
        <property type="entry name" value="L-serine dehydratase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050147">
        <property type="entry name" value="Ser/Thr_Dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000634">
        <property type="entry name" value="Ser/Thr_deHydtase_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078:SF2">
        <property type="entry name" value="CATABOLIC L-SERINE_THREONINE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48078">
        <property type="entry name" value="THREONINE DEHYDRATASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00165">
        <property type="entry name" value="DEHYDRATASE_SER_THR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="11">
        <location>
            <begin position="15"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW58370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="342" mass="36529" checksum="C65E31585597D8D7" modified="2019-01-16" version="1">MAPVYQTTASSPPWITTPCVKSLSLSASAHCEVHMKLEQFQPSGSFKSRGVGNLVWRVVQRRSQMNHGSGAKTHFISSSGGNAGLATTTAAKMLGQDATVVVPETTGKYMRNKITAAGGNVIVHGPTWREADDYVRSLVAEDPSLAYVPPFDHEDIWEGNSTIIDELYLQFGGCPPSVIVCSVGGGGLLNGIMIGLDRYNWSDAVTVIAMETEGADCLAASVREGCIVTLPEITSIARSLGIKRVSDKTWEYSQMPNVKSVVLSDAQAAMACVRLAEEENIIAEPACGVSVAACYLPVLREVVPDFCRDTKVVVILCGGSSISAETLVEYRSQYSAVMTAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q9Z9</accession>
    <name>A0A3D8Q9Z9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_12430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q9Z9"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF315">
        <property type="entry name" value="FAD-DEPENDENT MONOOXYGENASE MDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12831">
        <property type="entry name" value="FAD_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="247"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW58500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="491" mass="53964" checksum="00338C6C270715E3" modified="2019-01-16" version="1">MGDFISNIQVPPEIASESGQHPSVQRYPLTGIEVLVVGGGVGGLTAALECYRKGHSVRIFERESNASTAGDMFSIGLSARRWLNHWPELKNEFETMFPKVPRTIIKKHTGEIAIQSAAMGRVDSTPKDASEEPMAMLLRPVFHQMLHNQIRKLGIEITYKKRAIEYTEDSAKAYVLTDDQQRASADVIIAADGIGSKSQQIINNGQVEAMLSGTAMYRAVCPSTLAVADQAVAKAFGLQAGEDSHAQEANSTTPSKESWHNTVEPSEVLRTISMTPGWGEGICGLIRSTPASCIISWPLIWRNPSTIWHSPQARVIQVGDSAHSFLPTSGNGATQAIEDAITVATCLERAASSLLFEDQTTSPTPSIVDLAVRAHNKLRFERVSCAQKLGFANAFLLHHTDWDGAKKDPGKAQPNIPQWIWRHNPEAYAQERWDEVHAYVTGGGVERESRGEESTFKNTNIPPGFQWSPWTLDDLVHKGKHARVKLEGDWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QA48</accession>
    <name>A0A3D8QA48_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_12418</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QA48"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF27">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01030)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW58488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="252" mass="28191" checksum="A6D3E14F30E1F228" modified="2019-01-16" version="1">MPAEPSASTSFANPFVSVVEFIGYAGRAASASQEVNCWSLGPFIIQGIFILVPPALFAASIYIILGRIILLTEGESYSMIKRTRLTKTFVWGDVLCFWLQAGGGGLQAASASATLPKIGNYVVIAGLAFQIVWFGFFLIVATTFHRRMLRAPTERSQQPEVRWESYLTTLYVCSSLIMVRSVFRVIEYAMGNDGYLMAHEAFLYVFDSVPMFIVVVWLHWKHPSEIGLLLRGQEPRANGFEIVTMRRKEAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QB32</accession>
    <name>A0A3D8QB32_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_11976</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QB32"/>
    <dbReference type="OrthoDB" id="3499582at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596:SF4">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G03140)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW59052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="850" mass="96004" checksum="2536A429FDB5C847" modified="2019-01-16" version="1">MLYSIFESPFTYTTSRVHQVLEGDRDDAESTDRSTRAEFTVNPIGYRTEYRDTRVIHHFATAESHQSQAAAWCQQCLDALDDTPRHVEIMDEVFSRLAICHFRPRRPIHEIAEDASHMLSRLPSIPLEIRETSISSSLSRVPEGFFLAGRERKWATLRVVQHVTRNIIRVALLPVMSNAGDSIASQVHSLGEAIAELFTYSLKIRKGTDRSCGWKTFLLKAFLWTQWQRCVMLNSWIVLKDQLKNGFNTDLSSLTLVSRMTADLLKPSNCLSGESAIEIVPPQPVPYVCKWALRLLQTDRASISLDFRRLFARYAELFGQLSPRCNRLDNGDIAQCAGDTLYNCNRFVGMKIDDQTTHAKSCGGMCNRLHWDENSYRNTEGARAVSLYQADNGLLKYCTASHGTMAISHVWSHGQGGRPEIEESGLNRCLHERYVKIAHGYSCDSYWMDTPCIPKDRILRDEAIEHINSVFANSKLTLVCDRDLMSINVNEMSIALQESILASVLLCDWNVRAWTLLEALRGRKNIQILCANDQTVSLRDMLQNVHREGSIDIATFFLTAQHLLPAALNPPGRNANKYWYLNETEANGALSMEQAASLLHLRHASRPGDEIVIWSLLCNDKPPRSKSDRSVLRDLHLVSDTNVHETTAEVPNGDPSLLLAEAFWKMKVGYMLKTGFLMSSAPRDIQRKGWRWAPSRPALPPPRPNGLENEGPVVSESYMPFDGQSTEGGTITPWGYMAKWLTHIFRIAKPPSKYKKLTHFQSMTSAKKFHAGQARISWISETFLQDDDWGALLQPVDSLGLPARYRGPAAGTLLAVVGSSDRSVWRWRGLYDWDGSVPVPELEEEEIVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QB52</accession>
    <name>A0A3D8QB52_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycoside hydrolase family 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_11990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QB52"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF53">
        <property type="entry name" value="BETA-1,4-GLUCOSIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017795829" description="Glycoside hydrolase family 1 protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW59066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="643" mass="70908" checksum="82F8E0BB2AE3CF14" modified="2019-01-16" version="1">MKASLFSLLPLLLPAAAQQVYISSNGSSPRPWCTSAVAVTTYAATPTFYHSNFSYTQTETVRTATAVQSTTPAPTYAPAYSAISSLLNNISTTTWGNWDPSAAATTTAPSSNDPYGPAAFSSLWEWAALSSFSRGAYSTTVSPTAVPTSSLILPPPLYFGPTDCLPVPKDFVFGVAGSAAQIEGAVADEGRGPAISERAGQIPIPAFTSGLNDSQLSNNFVATESYYLYKQDIDRLAAIGVKYYSFSISWTRILPFGLPGTPVNAQGIQHYDDLINHILEKGMIPMATIFHWDTPLVLTGLDPMATSDSGYLLGNFNFGAQNSTFREALVNYGKIVMTHYSDRVPIWVTINEPQTGIVTGPSFYNVIMSHADLYHFYHNEINGTGEITIKMAVTPGVPQDPTDPTHVAATEHYNEILLSDYLYPLALGQDYPDAFKYTLQDYIPLSTDDLAYVGGTVDFIGVDVYSIPVIIPVVDDYQACGLNNDTTSNPYWPYCVYPVYETVNGWNVGYDNNDAVYTEPTYLRTALNYLWNTYQVPVMVTELGISLYGPGTTDFVGITSQQYDVERSHYYLSYLTEVLKAIWEDGVNVKGVIMWASADNWEWGSYEFQFGLQYVDRTTSTLDQYYKRSLFDVVDFVESRRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QBM0</accession>
    <name>A0A3D8QBM0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_12179</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QBM0"/>
    <dbReference type="OrthoDB" id="2094269at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF7">
        <property type="entry name" value="SERINE HYDROLASE FSH DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="2"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW59255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="276" mass="30876" checksum="4B547A94FAF3DB0C" modified="2019-01-16" version="1">MRTLMLHGHATSAFIFKAQTVPFRSKLDKTFSFDFVDGPYPCAPPRGLSSVVSIAYTWFKSPDANSIRNAVAWLTQYIEKNGPYDSICCFSKASVVVVAMMMYAAREGTDESRKRIMPKSLVIMNGGIEYSFLEDLGLPITEEARRIKFKTEEQVRSKADALSKLSRATVRPGATNGLWDDTSRLMHDPTKLSPLSNCFGLDFTSLPEDLLIHLPTVHILGGKDPIWPSSVQLANLCHPDKRSFYDHRGGHDLPRTPKVSSDIAEIFKDLARKLHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QBS2</accession>
    <name>A0A3D8QBS2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_12081</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3559145at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030020">
        <property type="term" value="F:extracellular matrix structural constituent conferring tensile strength"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008160">
        <property type="entry name" value="Collagen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057230">
        <property type="entry name" value="DUF7908"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1095">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01391">
        <property type="entry name" value="Collagen"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25485">
        <property type="entry name" value="DUF7908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="1259"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="386"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="426"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="454"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="542"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="574"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="604"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="659"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="682"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="698"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="716"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="752"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="792"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="873"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="951"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1077"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1235"/>
            <end position="1250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW59157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1363" mass="121272" checksum="4BAE1D763B828C68" modified="2019-01-16" version="1">MVYRPVYISSFINVNTEIVINGGLTISITNAPTNLLLTTTVLEATTITLGINSSTPTNGITSASNSQLLSASAVSSSLLSLPAPPTGALSSSIPPFIPPATNLLLIERGFIVELVVTEPRFARRQVAQRFGVASNVTTEACQLATAYSLANGQLFADGNLVTGSTAFNFGPLGPLTPDGDIVDGFSIMNNMLFWNNPTFTNQVARYCISASNIITAVYRGAVPNGCIPVILNILAISECFPTISVTGITSGVTGPTSFASSLSTTGPSSPAGTTITSAPVSSSGGSGTAGATDLSGTFGQSGVTGTAGATSSVDLSGLSASSGSSSLPNGTGSAGATGTAGQGGSGTSSGLSSTSGPGSSGATDASGTSGQGSATGTAGQGGSGVTSGTTGLSGTSGSGSASATGSGGSTGATGTGSEGGTGTSAGGSSASGSGSATATGTSSVDLSGGSQADGSGSIISGTSSSGSGSTGATGSASQGASGTSANSSSASGTGSTGTPGSSSTDATGTGSQGGTSTSASGNGASGSGSASTSGSGSGSTGTTGTTVSGSASVSGSGGSTSATGTGSQGGTGTSAGSSGLSGSGSATATGTSSVDLGDGSQADASGSIVSGKSSSGSGSTGTSGTASQGPSGTSASASGISGSGSADTTGTSGQGGPGSSSVLGGSSGSGAATTTGSGGSTGTDTNSVSGSGSASATGTGGSSGTNGVSGSGSGSGSASATGTGSQGASDTSAGASGASGSGSATATGTSSIDLSDGSQADASGSIISRKSTVSGPSGPSGPSGPSGPSGPSGPTGTAGPSGPSGASGLSGQPGSTGATGETGATGATGPTGATGPSGPTGVTGPSGPSGPTGVSGQSGIPGSTGPSGPSGPSGPTGDTGATGPTGATGPSGPTGVAGPSGPSGPTGVSGQSGIPGSTGPSGPSGPTGATGVSGQSGIPGSTGPSGPSGPSGPTGDTGATGATGPTGPTGVTGATGPSGPTGATGISGQSGIPGSTGPSGPSGPSGPTGDTGATGPTGLTGPTGPTGPTGATGISGQSGIPGSTGPSGPSGPTGATGISGQSGIPGSTGPSGPSGPSGPTGDTGATGPTGPTGVTGPTGATGISGQSGIPGSTGPSGPSGPTGATGVTGATGPTGVTGPSGPSGPTGDTGATGPTGVTGATGPTGATGPTGPTGATGATGPTGATGVSGQSGIPGSTGPSGPSGPTGATGTAGPSGPSGPSGATGPTGIPGPSGPTGQTGPAGPTGATGPSGASAFAASFAYEGCSTTAISSAFTASLQAIPFTSITIESCAVACANYFYFYIEQGLYCNCLTPLGNGNLTTLVGNQNCNVRCLGNTAQYCGGASTNPVTLVTTYYYSVFQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QDU9</accession>
    <name>A0A3D8QDU9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">dual-specificity kinase</fullName>
            <ecNumber evidence="1">2.7.12.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_11622</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.1" evidence="1"/>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QDU9"/>
    <dbReference type="OrthoDB" id="283111at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14134">
        <property type="entry name" value="PKc_CLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000612">
        <property type="entry name" value="Serine/threonine-protein kinase AFC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="309"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="67"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="144"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="200"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW60016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="689" mass="77123" checksum="0A51213E3558BB50" modified="2019-01-16" version="1">MSTPSTLPPPYHPNYGYSHHQNIYQASNGGYRANNNSLNGVGRLGGTYFPTASNNDTLLNGIGIADSPPQSATYTSRVETKQPTMPASSSTVKQNTKKRQRSREPREPDWHQFYKNGLPKEVIVIDDSPPPELSTSVISNAPGRAVAGSATKQHAAKKRKRDDAGQMFDPVYQLNPSPSNGVSPAYKDSGSASTISTDRTTSAIHTTAATSLGSHSSNGNGYEAVDVQPGQKRKRTVTRQQLANEAKRRELEENGDAFTNYKPPPRPPIKAQEVNVKVVHDNSYTKNQKVDDDDGHYIVVPDSDLTDRYSVTKLLGQGTFGKVVQARDKRRNKLVAIKIIRSVQKYRDASRIELRVLSTLKANDNENRNRCIHLRDCFDYKGHICIVMDLLGQSVFDFLKGNAFVPFPNSQIQNFARQLFTSVAFLHDLNLIHTDLKPENILLCDSSYQAFTYSRRIPSSSSTVNRQAAQRRVLLDTEIRLIDFGSATFQDEYHSSVVSTRHYRAPEIILGLGWSFPCDIWSIGCILVEFFTGDALFQTHDNLEHLAMMENVCNKKLDNHLIQQVNKMATRSGGNPAAKFFKRLKLDYPTPDTTRASRRFVKAMKRLDEIIPESNKFCKNFLDLLKKIFVYDPSQRITAKEALQHPWFKEPASPDDGTEAAKIRLQRIQAREEAAAAVAAGAPRHNGYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QDX4</accession>
    <name>A0A3D8QDX4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Xaa-Pro aminopeptidase</fullName>
            <ecNumber evidence="5">3.4.11.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Aminoacylproline aminopeptidase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Prolidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BP5796_11649</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Catalyzes the removal of a penultimate prolyl residue from the N-termini of peptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide.</text>
            <dbReference type="EC" id="3.4.11.9"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.9" evidence="5"/>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QDX4"/>
    <dbReference type="OrthoDB" id="10261878at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01087">
        <property type="entry name" value="Prolidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007865">
        <property type="entry name" value="Aminopep_P_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052433">
        <property type="entry name" value="X-Pro_dipept-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43226:SF3">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE AN0832-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05195">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01011">
        <property type="entry name" value="AMP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminopeptidase P N-terminal" evidence="14">
        <location>
            <begin position="38"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00030849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00032413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDW60043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="538" mass="60195" checksum="FA5317BEA03CEC49" modified="2019-01-16" version="1">MAVYVQKEEQRQICDDLVFVEEFDALSIEYKPKPVEKYPAKLHAQSVARRLGVRDGLIYLPGLTEASYEDSDMAPAFRQRRYFYYLSGCNESGYAVTYDIHTDKLSLWMPPQRDPHSAIFNGVIPSVEEVKATYDVDYVERVTKLDDYLTFYAHHNLGYIYLLHNYQVPSGVKAVMSYKDGSTSRLDSSPFDSSKLLNAMDAARAVKSPWELKAIRKASAISALAHINVLRGISRFTNETEIEAVFTATCIASGAKNQAYGVIAAAGPNASTLHYMSNTSSLKGQQTVCLDAGCEWKCYASDVTRTFPISGSWTPEAKEIYDLVAKMQEECIAMVKPGFNFRLAHLHAHKVALEGLMKLGILYNGTANEIFVSGVTTAFFPHGLGHFMGLEVHDVGQDAPSSKADYALYGFRDNPTSWASAFGEMLRTSPRMASVASLEPNMVITVEPGIYFNRWAIEEVHLKTEKYAKYINKDLLEKYYPVGGVRIEDDILVTKDGYENLTTVPKGDAALKIINEAREKREGKQEAVEESKKKGWLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QEM1</accession>
    <name>A0A3D8QEM1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SPT2 chromatin protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_11793</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SPT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QEM1"/>
    <dbReference type="OrthoDB" id="5430658at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013256">
        <property type="entry name" value="Chromatin_SPT2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08243">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00784">
        <property type="entry name" value="SPT2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="174"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="245"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW60187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="319" mass="34570" checksum="EC119EFA0B6A7BA6" modified="2019-01-16" version="1">MPIGDLLAQISGEPSPTLAPSTLPPKRKADNDLRQPVDKVQKMPTPAANSSRPMSQPRPPTLNTSMDRMKIGMNGRNSGSAQAAAPKSATPPVSATAPKAPPKKGSFAEILARGKAAQATLGPVGKIQHKKIEKRPTKKEMEDAKAQQAKNVRRGVERNGVNGKSSKPGQGPSRDPREGTKKVDPEPEKKVKKAATATTGYAGTARPKPGSSQSRPSPRYGREEPRRNGSGSGYGGTSKRYTYVSDDEDDEDMEEEEDYASDVSSDMEAAAFEVDEEEELAARIARKEDAEALAEENRLKREKAERKRRLEAMARKSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QHZ7</accession>
    <name>A0A3D8QHZ7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_11365</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QHZ7"/>
    <dbReference type="OrthoDB" id="419616at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17330">
        <property type="entry name" value="MFS_SLC46_TetA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23504">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="286"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="354"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="59"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW61473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="492" mass="52459" checksum="236E369B3BF84F93" modified="2019-01-16" version="1">MAASGTGNGGTSGSTQDEATPLLAAAETGPTSQPNEESLLIPAASQQADDDDRPLPKVQIFLLCYARLVEPIAFFCIFPFINQMIWETGTVEQADVGFYSGLIESLFSMTQMFLMIFWGRAADRFGRKPVLVFSLAGAAIATALFGLSTTIWQMVVFRCLAGAFAGTVVTVRAMITENSTPKTQARAFSFFAFTSNIGIFLGPMIGGVLANPADQYPSVFGKVQFFKDYPYALPTFATGAVGLSASIISAIFINETLDRKTAGKSSDTTPLSTWEVLKSPGVANVLYIYAHVMVLAFAYTAIFPIFCFTDPQLGGFGFSPLYISIFLGGSGLSQALWTLLIFPPLQHRIGTGGVLRACAIAWPFFFLVMPISNLLLRKGWNAAFWTLSSTGVLVGSGASMAFIAVQLALNDISPSSSSLGTLNAIALALISGERAVAPALFSSLYATGVRLGWLNGQLAFVILIVLAVGLSFGLRWLPAKAEGKIQPAHNEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QL78</accession>
    <name>A0A3D8QL78_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Acetoacetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_10857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QL78"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921:SF4">
        <property type="entry name" value="ACETOACETYL-COA SYNTHASE (AFU_ORTHOLOGUE AFUA_8G04770)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="118"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW62555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="695" mass="76905" checksum="D3CB6BBF15FCBA3C" modified="2019-01-16" version="1">MDYLQVPRKLWEHPDPTSTEMYKLMQEINQRHHLNIKTFWDLYQYSISRRAQFWDQCFQYLNLIYSGSYETVVDESARIDSIPVWFDGVHVNFAENLLYSRRAGTPASQRGTLGKEDGKVAVTEVREGATEIRHVTWGQLRREVAVLASAMKAHGVQKGDRVVVVASNSVDTLKVLLAVASLGALFSSSSTDMGVQGILQRTLQVTPKYIFMDDTTVYNGKTVDLRVKMTEIVNGMTGCENFVGMVSMPRFVEAKDISNVPRTETLARFSSKATSSQLSFEKTSFRDPFLVAYSSGTTGVPKCIVHSIGGALVSSVKEMKLHRELTPESVALQYTTTGWIMYFSSVMALQPGCRVVLYDGSPFQPDLTTFIKLLADQKVTKFGTSPRWVHEMQKNGIKPKEVADLSNLKMVVSTGMVLSDQQFEWFYDVGFPKHVHLGNISGGTDLAGCFAQENPLTPVYVGGCQGPSLGTPLAVYDSLLEGGKGVKGTEVTHGTAGELVAPAAFPNVPIQFWNDAAGAKFSAAYFEKYDGVWTHGDFVMIHPATKNVVFLGRADGVLNPSGVRFGSAEIYAVLENDFPALADAICVGQRRPQDDDEAVMLFCLMKPGEQFTARLVREIKAAIRTQLSARHVPKYVFETPDIPTTVNLKKVELPVKQIVSGKIIKPSGTLLNPQSLEYYYQFAKVEDIVNPKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLD9</accession>
    <name>A0A3D8QLD9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alcohol dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="9">1.1.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_10911</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a primary alcohol + NADP(+) = an aldehyde + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15937"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15734"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.2"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:15938"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:15939"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.2" evidence="9"/>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLD9"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008106">
        <property type="term" value="F:alcohol dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000158">
        <property type="entry name" value="Zinc-binding alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="63"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW62609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="407" mass="44048" checksum="EB14E5CA01328CB4" modified="2019-01-16" version="1">MPSSSSIKFPSSVAADRILAITNHLHDSLNPADDLRSVKDKMGADTSYKFQGWMGLDKDSDKGNMVWQEFTPKTWSEDDVDIKITNCGICGSDLHTLRSGWAPALYPCCPGHEIAGIAVRVGSNVKHLQVGDRCGVGAQSLSCLKPDCWECSSGMENHCMNLNVTTYNGKYADGSKSYGGYSDYCRAPSHFVVKIPDTISLAEAAPMLCGGVTTWSPLVKNGAGPGKNVGIIGIGGLGHFGLLWAKALGCSKVVAISRSRGKAEDAKKMGADLFIATDEDKDWNKKNRCTLDLIISTVSSPNMPLQKYLQLLRTNGQFIQVGAPEDKIPAFNILALINRGVNIGGSSIGSPKEISDMLKFAAEKGIRPWIEERPMKDANKAIVDMENGKARYRYVLKNEANVKELGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLI7</accession>
    <name>A0A3D8QLI7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_10964</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLI7"/>
    <dbReference type="OrthoDB" id="5397701at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37331">
        <property type="entry name" value="YALI0F11671P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37331:SF1">
        <property type="entry name" value="YALI0F11671P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW62662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="234" mass="24407" checksum="4E0B24422E36B81A" modified="2019-01-16" version="1">MISTRLLRPQTTGKLLRQAVRCASTLDSNPNIYVFPSPTSPSVHILTLLPTSPPNSSLAIGTTSKLPPTPDSVRENPKFLSILDSVLSAHAHKDPGLVAQAAVFASTSGSALGSGGMFFPTQNKRGRKGKGGAGSMAGDGAGGASSQGGAGGGGRGGWVHLSDSRAPPDYGRIAWPEDIFGSLEVDGQGAIVGENGNWQRSGSYRVITRDGILGLSDFLREKLVQRLREEESKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLS9</accession>
    <name>A0A3D8QLS9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_10912</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLS9"/>
    <dbReference type="OrthoDB" id="5390at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06185">
        <property type="entry name" value="PDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.20">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006058">
        <property type="entry name" value="2Fe2S_fd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052353">
        <property type="entry name" value="Benzoxazolinone_Detox_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30212">
        <property type="entry name" value="PROTEIN YIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30212:SF2">
        <property type="entry name" value="PROTEIN YIIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00409">
        <property type="entry name" value="PHDIOXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00197">
        <property type="entry name" value="2FE2S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="4">
        <location>
            <begin position="48"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="5">
        <location>
            <begin position="250"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="3">
        <location>
            <begin position="474"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW62610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="563" mass="62244" checksum="BF8F5805927BC269" modified="2019-01-16" version="1">MPTDQHHTRRLPADPVQDAGGHFSGSYSRCPVQNGQGLSITSGILKDSRGDDAVFCSYNGLESDEHDLTFHGGVDKAVHQYCSLHYPSWQSDFPDNARLFTVGGFGENIVSEAMNERNVCIGDIMQIGNESSGCILQVSLPRQPCYKLNHRFEIKAFASQTWKKSRTGWYYRVLKEGWMKRGDEIVLLERKHPKWTIERIQEYLHRDGNKNVPVLKELLAIEEFGAECKRHFTGLIAEAEKGPNAKKEPEIFAEYKLVEKKRQTPRIVAFTFEATDPKGVANDVDPGSHVRLKLPNGLIRSYSLVGGTTHKLMLGIALEEQSRGGSRYIHETLAIGETILVGKMTTSVPIAGGASNHILIAGGIGITAFLPTTAVFDQININYDLHYAVRSSEDVAFKDMLEKMAGTIRIYDASKGERMDIPTILKTRKWNSHIYVCGPQRMNDAVTQTANLLGIDPDEIHSEAFQALNTGDPFTFSLKAAEQTGDTSKRIFKVAEDESLLAVLRKEGFEVDSSCETGNCGACKIDLCAGSVEHRGSALGVTEKEMGMLSCVSRGQGHIVIDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QM13</accession>
    <name>A0A3D8QM13_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Tubulin gamma chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_11141</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Spindle pole body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QM13"/>
    <dbReference type="OrthoDB" id="10249382at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005816">
        <property type="term" value="C:spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02188">
        <property type="entry name" value="gamma_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000004">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000003">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000012">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002454">
        <property type="entry name" value="Gamma_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01164">
        <property type="entry name" value="GAMMATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="10">
        <location>
            <begin position="48"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="11">
        <location>
            <begin position="249"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW62839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="460" mass="51400" checksum="8621024EDB12676B" modified="2019-01-16" version="1">MPREIITVQAGQCGNSIGSQFWQQLCQEHGISQDGNLEEFATEGGDRKDVFFYQSDDTRYIPRAILIDLEPRVINGIQTGPYKNIYNPENFFVGKNGVGAANNWGDGYQTGETVHEDIMEMIDREADGSDSLEGFMMLHSIAGGTGSGLGSFMLERLNDRFPKKIIQTYSVFPDTTNSGDVVVHPYNSLLSMRRLTQNADSVVVLDNGALSRIAADRLHVQEPSFQQTNQLVSTVMSASTTTLRYPGYMHNDLVSIIASLIPTPRCHFLMTAYTPFTGDSVEQAKTVRKTTVLDVMRRLLQPKNRMVSTIPGKKSCYISILNVIQGDVDPTDVHKSLLRIRERRLATFIPWGPASIQVALTKKSPYMPMNHRVSGLMLANHTSIATLFKRIVRQYDGMRKRNAFMEGYKKTAPFAENLSEFDEAKQVVTDLIAEYEAAEDANYLNPDEVPTGEASDRRMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QPW6</accession>
    <name>A0A3D8QPW6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosomal protein L21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_10368</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW63866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QPW6"/>
    <dbReference type="OrthoDB" id="1539250at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.70:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3260:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="entry name" value="Ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_eL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018259">
        <property type="entry name" value="Ribosomal_eL21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_eL21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01171">
        <property type="entry name" value="RIBOSOMAL_L21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW63866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="23388" checksum="A7A553EEDA44C065" modified="2019-01-16" version="1">MGKNPWGNGARPTSCFQENFSWSPEHVLGLGLRWSVLLSSANLLLQQVIQLVFARVPAMPSPEISSSKKGMIKLSTYLRQYKVGDIVDIKANGAVQKGMPHKVYHGKTGVVYNVTKSAVGVIIYKKVKHRYIEKRVNLRVEHVSLSRSREEFVRRVKTNAELKKKSKAEGTHVHLKRQPLMPRESRTISMKDNVPETVVPIAYETTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QPX7</accession>
    <name>A0A3D8QPX7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Palmitoyltransferase</fullName>
            <ecNumber evidence="11">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_10378</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="11">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="11"/>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW63876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QPX7"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF43">
        <property type="entry name" value="PALMITOYLTRANSFERASE APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="358"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="473"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="518"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="13">
        <location>
            <begin position="428"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="598"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="152"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="218"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="598"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW63876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="645" mass="70815" checksum="09DC19DB1617EF4E" modified="2019-01-16" version="1">MQQFLGTEAGDRSSVISSRMTDIASEDGRDNVLNDPTNPTATQSPNGASRPTTGVTRSSSQRAAWTQAPPSRRGQGPTPSSQRGSIPGSLSGSISRPPSSSRTHVPSLTSHAFFRPMSSQRLQAQRGGSRPPPVSQQATSEEGSVEGGGSVRQSMRSNEFVGQSARIQEDAEMQPPPSRGTEMTEPEITDRVTANTSPTHGYTAEGSMADSVRPLQRNVANTKGLSLNTDRNYMPGSGTATPAKSPRSFRSSFLLPSRGGGTSHTPSPNRSTQGREKLSSIASSPGLTPVDPPKHVMKQNLGSNYQYFTGNTAFCLGGRLQNTKDKPINIATGLLVVVPSALFFAFSAPWIWYNISPAVPIVFGYVFYICMSSFLHASSSDPGILPRNLHPMPPPDENEDPLRLAPPTNDWTMIKSATSATAAMEVPTKYCKTCQIWRPPRGHHCRVCDNCIETQDHHCVWLNNCVGRRNYRYFFAFVTAGTLLGTFLFAATLAQLLVYANQQSISFDASIRHFRVPFAMFIYGILATPYPAALMFYHLFLMARGETTREYLNSHKFLKKDRHRPFTQGSAIKNWIVVLCRPRPPTYLTFKQKYQEGDQRFGEKRGRPAPAAKDEQAGMEMQNVPPPQTGFQGPTTLDEERASRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QRD0</accession>
    <name>A0A3D8QRD0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">beta-glucosidase</fullName>
            <ecNumber evidence="4 10">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_10556</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4 10"/>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QRD0"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF3">
        <property type="entry name" value="BETA-GLUCOSIDASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56988">
        <property type="entry name" value="Anthrax protective antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="11">
        <location>
            <begin position="413"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW64054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="849" mass="92833" checksum="B51E450EF5D7B5E6" modified="2019-01-16" version="1">MADAQFQDLLDQLTLEEKISLLAGADGWQTQEIPRLGIGSLKTSDGPAGARGALSVDGPPAAFLPAPVSQAATWSKDHLYALGQLLCREVKTKAAQVLLAPTICCARNPLGGRNFESYSEDPVLSGQLAIQYVRGVQETGEVAATVKHFVANEQEYQRFTINADISERALREIYLRPFETVIKSKNPPKCVMSAYNLVNGAHMDASNILQDILRNEWGFEGLVMSDWGGTNSTVESLIAGCDLEMPGPPEKRGSLLLEAAQTKPQGLLEAIDASALRVLKLLAELKLLNLSPEDAVKTRRGVETSSDNKDDQKLLREIAADGIVLLKNSNNALPLDPYSLSGKKIALIGPNALNGTPGGGGSATMVPLYQTQPLAAFESALTEMNIPATIKHSPGAFIHKWLPLVDSKFVADDNKSMIRLDFFARDDFSGPLVETQYRDSSYVDLFDSAPSAWYEDKKPHSVKISSRLTPETTGLHSFGISSVGHARLFVNDQLIIDNFDWKKVGEAFYSFGSVEVQASYEMTAGETYDIRLEASSKVIPKDAASDDPVHVFGVQPSVRLGFIEQLPSDPIGDAVKLSNESDVTIVIIGLNDEWESEGYDRQTMKLPGGQDALIESLLRESNKPESIVVVNQSGSPVEMRWANKIGTVVQAWYGGQEAGNALADVLLGRVNPSGKLPISWPMQYEDLGFEAKSWPGVDGVVKYTEEMSVGYRRYQNAQIQPRWWFGHGLSYTSFKYEEAGLSKEDDGWVVSVTVKNTGSLAGRDVVQCYISAESTKELKAFEKTSLLLPGASETVHMRISARDMAHWNTESKKWVLQAGTYGLYIGSNAGDEDAIKQQLEVVQETEWLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUD1</accession>
    <name>A0A3D8QUD1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative eukaryotic translation initiation factor 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_10145</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUD1"/>
    <dbReference type="OrthoDB" id="10250831at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071074">
        <property type="term" value="F:eukaryotic initiation factor eIF2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11561">
        <property type="entry name" value="W2_eIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000031">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.350:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF7">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00515">
        <property type="entry name" value="eIF5C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="7">
        <location>
            <begin position="259"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="145"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="246"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW65453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="427" mass="47306" checksum="1ECDEF6A086DD91B" modified="2019-01-16" version="1">MATVNIRRDVSDPFYRYKMEKIQSKIEGKGNGIKTVIVNLSSVASSLARPGAYVIKYFGFELGAQTNTNPADDRWIINGAHEASKLQDYLDGFISRFVLCKKCKNPETEVVIKDGRILLDCKACGQRSDVDLRLKLSGFILKNQPKKGKKDKAAKKEARRAKQNGHGDTEENGHGDSGDGSDHGSNENGDIGVEAGSDDELTRRIKAGAEEVDTPVEVKDDEWTVDMSAEAIKARQQQLPDDLKQKLVLGGGDDDEDGEGGGNSSYDQLGTWIISEAESKGGVSKVQDIDIYVKAKELGIESKHRTLLVLVQTIFDDDIVKQIPARASMLKKMTTSEKHQKSLLGGIERFIGFRGEEKPDFYNQTSKILMVLYNEELIEEDVLSKWGTKATKKYTGDISISKKVRKSAEQFLTWLAEAESDDDEDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUV5</accession>
    <name>A0A3D8QUV5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_10318</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUV5"/>
    <dbReference type="OrthoDB" id="4216928at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="9"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW65626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="425" mass="48081" checksum="2660A8771E9555DC" modified="2019-01-16" version="1">MSATLRQKACISCAESKRRCDKQLPECQRCLDRDADCVYPQRKKDRRNPTARIRQAAELPSFSNFADADVLGNSLEFGDWVSMGAADPTVSLLDVTILYVPTLSTSFTNLSTQGTLLERGDVANKPSPWFLRDDTWAMKPCNHEPACVTYVELEPFVGAVEEMLQCWVRTGHNSFIHRRLYEKGMPTCLQDAFTTLAAYSGRTPAMKETILQIAEERSSALASQSPPTAEGAQGILAHLARVQALFIYEFIRLFDGSVRLRASAEQQLPTLRLWVIRMWETAKRYRGQDGYLPSSWTASEFDREYDAASQMWQLWILTESVRRSHLIIDTIANIYDTMTKGWAECSGAVMFTTRHGLWEAESAMKWFELSCAKSPLLVPSLQPGPLISEYAAEEIDDFAKLYWKFVVGTDKIQCWIDKGSKTSRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QZ83</accession>
    <name>A0A3D8QZ83_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Arrestin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QZ83"/>
    <dbReference type="OrthoDB" id="2333384at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011021">
        <property type="entry name" value="Arrestin-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF166">
        <property type="entry name" value="ARRESTIN (OR S-ANTIGEN), N-TERMINAL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G02050)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00339">
        <property type="entry name" value="Arrestin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arrestin-like N-terminal" evidence="1">
        <location>
            <begin position="22"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW66971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="398" mass="44960" checksum="A149BA7E13E23641" modified="2019-01-16" version="1">MSNSLNIILDRHGSDGNSHAARPHLFIPGERVTGKVVLTLEEDTEISAVVIRFRGKCKTQVPHNEDVTISHKFFMFAFEKRLFEGPFTLEADTHEWPFSFTFPEHYEMKGNPFRGIGCAGMSKPPTRRLPMLPSMSMHAGETEAHVQYKLQARVPRSFVDWKSKVTLHLTPVRLEALPDPHVISRKQVHAPWTQLYRYSENFVPRPLSSKEKFKSKFHAKADNRSITFSFSASAPTAIVIGRPYPVTITLNTEPTDMVIPTFILHTPRAHLDAHTNLCVPGSFHDHKAYKEQSIGLNNISTTNFEMPPNKPVTLKHVFPKMLHAPPTFSSLSLARKYGLSIHFKITMLDEKFDVVCKFPEVTLFAAKMEDGVEEAINAMNQAAPRYEGPSDGPPTYNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R2K8</accession>
    <name>A0A3D8R2K8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">CDP-diacylglycerol--inositol 3-phosphatidyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_08940</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R2K8"/>
    <dbReference type="OrthoDB" id="10251079at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003881">
        <property type="term" value="F:CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000011">
        <property type="entry name" value="Cdp-diacylglycerol-inositol 3-phosphatidyltransferase pis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF4">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--INOSITOL 3-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="132"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="176"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="464"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="464"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW68283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="57812" checksum="79B2988F96833688" modified="2019-01-16" version="1">MSSVRTRRQAAAVSTPATPTPMAKRDQQIMKENGSAKAADEVVSKENIFLFWPNVIGYFRIVLAFGALYYMPLHPRTCSLLYSISCLLDALDGYAARYFEQSTRFGAVLDMVTDRCTTACLLVFLASAWPRWALLFQGLISLDLASHYIHMYATLVMGTSDQSHKKVDKSRSYILYLYYTNKTVLFLFCALNEVCFIALYLLSFSSPLLSPSLLQTGTTGSTLQPGNPSTPPVSSLFANPYSAGALELARANKMDSFWPWVIFGVSFPVMAGKQIINVVQLVKACNWLAEGGLVLHNASKRRATECASSYEEAKGFDATCLETSKSSWRVCNGVPDVSGNSGDSPWTGGRFRGGPCTGVISYLAGRTTRDGLGMLEAAAIFISGTPCNVVPPHPAVSFLLRDPTLPAASATPAAQRQPTTVSCFQLTCGAGQGRGLPVHTHPPKLVLTLSHTAPRPRRCFRVNVDHPSNRRHPDSARTQAGQTPGLPFTSFRIGCIADQTCPCLPLLNSATIPTWYLSGLVRIQLDSTRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7A2</accession>
    <name>A0A3D8R7A2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_08329</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW69932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="4850289at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="896"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="937"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="1142"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="697"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1232"/>
            <end position="1473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="697"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1240"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1262"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1305"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1323"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1423"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1463"/>
            <end position="1473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW69932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1473" mass="166064" checksum="232B26F82B4B3881" modified="2019-01-16" version="1">MATRNEINLNRWGEGDPNDDGGDPENNEVAPLAPLPLDPDVAARIQAQSLDEYMARLQRQQFLNEKVENSKIIQKPGLDRNDPNYQEVRKQIRERLRTESIQSIMDDELDEVQRTLLVSPIMDPGGFLLNIQELRSQSYKTALRSPKWKGEMDNIATKLAMAKFGLPVQPITFSNQLALIDPTKDQDDPEDKTDTVPPIQRVVNSGTPLGFLDEYWERFYGYPGNRRARPTTLGLRGGAGCIEDIASYADGAYRNSLYDEAFLTRGFSTPALRLRGGDLQVNHTVYSYNGYAELPDCRVEGFIDASLRLLHYPSRDSANGNTSWAFKIYFSGVLPSLFKSRSVHVNQENYNKVWHDNEKAFESCLTGEASLHPDGGSQFLFVCHRGLPLPDSPTPIDDHHVIRLTRIDNSLALTVYWVLAKNLDGTHGLNQVQGDFYSAMKILASDHEFQGRVVINKCNLGFAGMEATQELWDAAKKSLKRRHPPQPWKVSVRPINQAAGLHLIGRSNIAVWRPQDYQGAFDAIKSLFQDLGAGRSGNIDKIRMFPTLDARLNGSGSAIIPLGDSAEGTKRIKNVWESQPVHLQGRCLYFRPEFSVLQVQEVGNDANRITWTVENTLQPDIEFMSKVVPKLFPGFDRQKDFITIPQIEPEEKFVISPDLSLKDRRVFVFDYLNREKICVSRGGDAYDREKLWGCDNSSPQFASSSTAAGTQPPTDPNPPAGTKSPTGPNPLAGTELPTCINPPALSGLRINQPRLLAARALKPQEMAFKPWRKLQDEKDAERLRAYTSYNSVAGPGRQGRIPITNNLRERSINVGSSMPQLFHQHRTPTEFKNLQDENISLRNQVLRRELCCPICTEKFPAYPQDDSQPGDGHLGEVDEVKRKHFQKHLKQCQAGGKCPLCDTDRFQFWSQDEKKQHLDNHYSVWYNQVANEERNGVYCRVCYIKFSTNLFPTVADITRHMETHVAGLKKFCDKCGLDMRNGRLEPWEQNQHLQKCINAPNKCTQGWPKEEQKYKRADNPEDMFCRQCGTDLEKANENEQTKKQHQNACDLKKKESKKWEYCGKCGVLLTLPQITEKQREAHAKKCIVPGGWSDRYCIQCGVETATLSDPQKNAEHIRSCRFKMPEFVDPSLRPQIPVETDHDCPVCKTRLPKDIKLLIAHMQTHARSPAKGDCHITQSCRDGLKSMRDELEKSALKYPNETPDIKRPATKMPSQKDVDDLLKRLDAAIRNAVNNGQQSKLDKPPGEGAKNEKAEREGGIIDLDDDDVDDDDVDDDDDDDDDIEEEETSHTEAGNQEGIPEGKRRSQRKRKRPRDKSYQQEQDSSEDFDLEPEPEDLDLKNLPPSSKKARLNLDTSFRPDHGDEDSDGNPVVSPIRTAKGKGRGGRKASSTSHVETVSLTKKASRLPGNRAASPEKKGKATVSRRSVSPREASTPTPQERSSRSRNATPSEPAESKKAASPSKRWRKSPAKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7Y7</accession>
    <name>A0A3D8R7Y7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nascent polypeptide-associated complex subunit alpha-like UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_08341</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW69944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7Y7"/>
    <dbReference type="OrthoDB" id="285219at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14361">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052617">
        <property type="entry name" value="Huntingtin-int_K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038922">
        <property type="entry name" value="HYPK_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31184:SF2">
        <property type="entry name" value="HUNTINGTIN-INTERACTING PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31184">
        <property type="entry name" value="HUNTINGTIN-INTERACTING PROTEIN K FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nascent polypeptide-associated complex subunit alpha-like UBA" evidence="2">
        <location>
            <begin position="89"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="42"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW69944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="133" mass="13860" checksum="9954D367EE39B786" modified="2019-01-16" version="1">MAEKQPPTIVEGATTGDVEDEIPVAKSAEDRKAAAALSSMDTPRDDETSGTKDVDQEAVRKAMDRLAGTGGSNGVAAKKDDAKVVKKAVKVDAADVALVVEELELSKIKATDLLKAHEGDVTKALRAYITPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCL7</accession>
    <name>A0A3D8RCL7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_07754</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RCL7"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42044:SF2">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42044">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="430"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="519"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW71720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="720" mass="79566" checksum="8179221EB25D68CC" modified="2019-01-16" version="1">MPWLSRSNSPNRIVTSQAPEDVIHKSALMDSSVTFIPAMIDGSCGTTPLSFRETPLQLLLNDLKIIGQNFACVPEMARSLCTLKSVKDLFESWRAFRDLLLQILLALIEIVALVMAVPMFLALPGGLFLGGCLIFGCVVALLSMPLKGSRILRNRHYAEGEFDDERWVFVNGSLTSHNQLRNHLSKLSDIFGRPVVGVHNRTNGIVLDLFSSLLAHCISFTTPTSTNLYTQLREPLLSPTMRKVIVLGHGTGAHLISLALDKLHADLPIDVLAKLEIYTFGSGATHLSNPPFVLEGSTSANGLGTITRADGSIISPVKATLASRGYRTEDTERVLPHCEHYALSNDITAKCGILHHTRNTLDNRFCGRVFAIDRPGFLLTHYLNTLFPINPLTTPNKALDEIVSVEVQTAEKREFTAQGVSMPLKTLSHSPRNSLSPLGSPRPLSQSAKEERRRSWNIGGIYGTGMDSIGQARNSARENEGKSVRQLSRLWRYVGGARPVGEGVPATNGVGVAAPPSPQAQYQHQQQQPGQPQQYGQQFPYPYSHNHYQQQQQGNVREVMTVSGANEDEEEHVEWHDAAIGPFNNDLYDNEDRNYDLDEEDEVQWHDALFEFVDVSDHGIDFVAITDTEINVSNGTKEKEQHCTRLTLDDQTTFHDAGAADWGMDLDLARDVDVTTVASVDLDLDMEVRSGERNSNVVVTVQQEGQGTCDNLDMLVALWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCZ3</accession>
    <name>A0A3D8RCZ3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Leucine-rich repeat-containing protein 51</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_07953</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RCZ3"/>
    <dbReference type="OrthoDB" id="5273213at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.190">
        <property type="entry name" value="CAP Gly-rich-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036859">
        <property type="entry name" value="CAP-Gly_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000938">
        <property type="entry name" value="CAP-Gly_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46545">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46545:SF1">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01302">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01052">
        <property type="entry name" value="CAP_GLY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74924">
        <property type="entry name" value="Cap-Gly domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50245">
        <property type="entry name" value="CAP_GLY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="CAP-Gly" evidence="7">
        <location>
            <begin position="36"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="553"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="269"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="555"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW71919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="613" mass="68267" checksum="F8BFE98ACF3CFC9F" modified="2019-01-16" version="1">MANSFHVGQRLSIKHQSCTVRYIGPVQGTKDESEEYLGLEWDDAARGKHDGSHLNKRYFRCQSTSSTAASLISARKVVLDPRQTFVEAVRHKYATNLADPLGPGAAEQKIMISISKVAEEVGFAKINAILAQLNRLRIVIVDGLSIYSADEPGEIKATCPAIVELDMSRNLFEDITPILKICGELEALKILRLNGNRLQIKDNDSSPQFQIGSVNPFNGLVELELNETLLSWVDICKIAQRCPSLTSLKASQNLLACLSSEPLPVVTRTSGFVNNNSNDSREKPSEASTNGLQQSSLVLTLKSMYLELNEFSNLADLAPLVFFKNLRNLHMKGNKISNISSSLPTSTEPIFDTNLRFVDLRNNGISSWDLVDALPRVFPGLTELAISGNPIWKAVREGGILAEEEDGYRLTVARLGNLKRLDFSEVTDVYRKDAEMFYLSQIGRALSKVPESEESMITALHPRYAELCSIYEPPVVFRSNDGSTNPDFLEARLIKLDFYLPPNTIPGQMEETHRLIEVPKAFSIYRAKGIVGKKFGLPTMKIRLVLETGDWQPDPDYHLESDDENRIDQAGAEQPGGDLRGIWNKREVEIEDSTREIGFVVDGLEGTVRVELR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RD41</accession>
    <name>A0A3D8RD41_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08003</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RD41"/>
    <dbReference type="OrthoDB" id="5344482at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW71969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="333" mass="35651" checksum="A27D3CB74896B443" modified="2019-01-16" version="1">MALHTPPFEADSVPATQGQIASAVSFSTAFARYEIESGRGNAGTKILMIEWGDEDDSDVQGDWEVSWEGKSTVLSAKDVAEDKLHRLYFLLPPASNVPRIVTLSQAGGRTMQTNPLPAIFPTELGITARAAGRKGVLHTIWAKKRLQVLGQEIDAEMKTNGEGVGLEMALQEKQWIEDHFGVGSKSVVDPQLSPSPGSPKTPGGGSGRLSEKLKGLRLETNSPASSQDAHPLSPDTSDIAVSSFSAFHGSSARPVRAVAQNPPDHIIAQQGGLGDNRRMNSLDAITGGEVPEKVDEVEEGLFAVRMSPRSPDMTQSPFSFTADDTAPWLKNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RE78</accession>
    <name>A0A3D8RE78_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH myb-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_08198</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RE78"/>
    <dbReference type="OrthoDB" id="3366990at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010833">
        <property type="term" value="P:telomere maintenance via telomere lengthening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11660">
        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000137">
        <property type="entry name" value="MYB DNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013867">
        <property type="entry name" value="Telomere_rpt-bd_fac_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052833">
        <property type="entry name" value="Telomeric_DNA-bd_trans-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47807">
        <property type="entry name" value="PROTEIN TBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47807:SF1">
        <property type="entry name" value="PROTEIN TBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08558">
        <property type="entry name" value="TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="5">
        <location>
            <begin position="478"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="669"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="670"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW72164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="713" mass="79843" checksum="8B5B642F1548F47E" modified="2019-01-16" version="1">MVQAPMPSAPMMAGTEDTTSKYASPYVADTLQDNGLKRRRSSENMEGYEKRQKVEPITLANDNLAALLAQATASATQAFSAPVSNGFEAPQTIQEPVVQHVNPAPVSTNGTSDPYLYMRILSLPILESLSVQILSRLAQGPYSETIRIITEPESELGQAYTTLKSLFDQTKKIYTRDEPFLSAEKLNIQETEHRATIRTTNLATFVSSVFGGQDVGFCQLNDHFIETFTPDGERLQKEPGLLYLNFKTQMYLSAVSEEEQDQTKEEILEGLFPDSLEDLLASRHPDIPLSQHEREFMGAIRGRREFLLLEPSNIESIQMLSEKFAWEDFLRRLSHYLSQTYEPLLKPYMQRHSLTAPAFPPQQPDQSHSPNMFAAYTEQTDVKPTRLTPQDIAERAKRAADAALRSVQYSQSFSTTPQQNGSLQHNTFQQPVQNSYHSEYNSATVPFPTQTAPTQVLYEQARQAAAAKATPTRSRPGLPSYQRRPWSQEEENALMAGLDSVKGPHWSQILALYGAKGSISEILKDRNQVQLKDKARNLKLFFLKSGIEVPYFLQSVTGELKTRAPTQAARREAEERARLANGEERARFNGIMTLAGGMQGHASEMLEEEEESSSLNDEIELFDFEVQDHVGGHPNQSMTLTPNLDENQNQNQNQNLNMDMSMGIDMSVSQDQEPAQTQTQLQSQQISDEDRFTQQLMAATAAAQSVSTDIHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RHW0</accession>
    <name>A0A3D8RHW0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">O-methyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_07077</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RHW0"/>
    <dbReference type="OrthoDB" id="1606438at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF12">
        <property type="entry name" value="STERIGMATOCYSTIN 8-O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="235"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW73635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="408" mass="44793" checksum="9BF7877851D892EC" modified="2019-01-16" version="1">MAPARSLLELASTIQAHTVAIDGALKSEALPEPTFQSGGPPVFGLPASQERDRVALLEALEEMRALLMGPVPYVVVSAASWIPQKLELNERISYAELGKRCGLTEANTQHIVRTAISLRFFEEPEKDIVMHNSFSHALATVPGVMDWVGFCAEDVLPAAAKWAECLKAYPGSEDTTKAAFAMANGGQDGYFSLLDKDAKRQQRFANGQGLIMAHPARDPVHFVNSVDWSGDKCPQTVVDIGGSNGPLMVAILNKFPGIRQGVVQDLPGVVSQAKVPDGLQDRMSFEAYDFFTTQPRKADVHIFRVILHDWPDADVIRILRNQIPVLEPGHRIILNEVVVEGSPDGRAVEDQQKWISDVMMHLLFNAKERSRDDWIALFAAADPRFHVESFTVVPPAVLSTIVVVWTGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RID5</accession>
    <name>A0A3D8RID5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_07096</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RID5"/>
    <dbReference type="OrthoDB" id="762982at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF49">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="245"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW73654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="638" mass="71827" checksum="702A354C27BC8AC7" modified="2019-01-16" version="1">MVAQQPHSPSEETASAPLSMSFRSGGAQAQPTPPPEVARAYPDGGGVIKLVGDQSFYHGSTHWADVLEEVQALKSTWDQVQSDELMPSVDESNVPDGPSLLYGLASPIELSELLASVPSKPAVDKMLQIFFNFVDPTVPTLHVLHKPTFMRQYEEHWIDPSKSSLMWIGLLFSILNLVMTGHGLLENELPEYKGMTVSLAELYRQRTAQCLMMADISKCLPYTVETLIFNMIAEYSRPNDNQRRVWMMTAVAIRAALQMGYHRQDTMVPVQGERLTFDRDPSNFPNISPLQGEMRRRTWSFLQELDSLTSFVVGLPSMIDSLGSDTAEARNVHDWELSEDMVELPPSRPPEERTAVGFLIAKSRVLKGLSGVVKSLGSCGHDAYDSVLALDRHLETIYNQIPSWIRLPDLKDVVKDSSVELAGRIKLEFYHHQGICALHRRFIGHNRSQEAFEPSRRRSLISAQALLSLQEFLYEESKIRGTYRSPLWYRISYANNDFILPATIIFLELHRRKESHAEGSQELWIMSGNDLELLRALQTSQSIWEAATEHSPQASRMCRILAYMVNSFSITARPLDTALQSISLSVSHTGLRSPSISQSPGIGLDSDIDWTAWTEFVERPAFEDAYLSVPINDDWSML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIJ5</accession>
    <name>A0A3D8RIJ5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">H/ACA ribonucleoprotein complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_07309</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9 10">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 10">Belongs to the GAR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIJ5"/>
    <dbReference type="OrthoDB" id="2187159at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034513">
        <property type="term" value="F:box H/ACA snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000454">
        <property type="term" value="P:snoRNA guided rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237:SF6">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237">
        <property type="entry name" value="NUCLEOLAR PROTEIN FAMILY A MEMBER 1 SNORNP PROTEIN GAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 10" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="128"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="8"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="148"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="196"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00053712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00062786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW73867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="206" mass="21001" checksum="DD9219428D6A35C1" modified="2019-01-16" version="1">MSFRGAPRGRGTGANFGGGGGRGGRGGFGGRGGFQQRDMGPPAAVLEMGSFMHACEGEIVCESINTKIPYFNAPIYLENKTSIGKVDEILGPINQVYFTIKPTEGIQATSFKSGDKFYIGGDKLLPLEKFLPKPKPPPGAPKPKRAGGARGGRGAPRGGARGRGAPRGRGGFSAGGRGGARGGGGGFSRGGFTPRGRGGFSRGRGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJ04</accession>
    <name>A0A3D8RJ04_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytoskeleton-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_07467</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJ04"/>
    <dbReference type="OrthoDB" id="5385189at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW74025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="334" mass="37536" checksum="C9C45B9D8F942087" modified="2019-01-16" version="1">MSTLSPAGQDRLLMFGLGLTACAVVGLMRHLLVQYRDDAIEKPVRGKPQYITQEVEDSLKLGTLAKLLKSTSHGIQDTASTIICERAVHDGSTIDILLWYIAQPDYESREQGVRALVHIMSTCSPILHLLNTPKGYSALVTSLQYSVDDYKHNVYDPDWDNWELRDMCERGCLMILGQLSDHYGVKGLVRAGFIEKWLAKEPWGGRNEDERQLAFMDSLAKDTRLADIAMPLFRDEAARLRLEATRLLPPRLEEQILDAGHVSSVKDVRMVGGEGTSGEGEEGDHFVQAFVEGLRRPRESSVEEAVVRQRHREAMVLNDGSRPLGRADIIERQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RNT0</accession>
    <name>A0A3D8RNT0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_06524</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RNT0"/>
    <dbReference type="OrthoDB" id="3530008at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW75703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="211" mass="23031" checksum="9B1DE20190A187BF" modified="2019-01-16" version="1">MTTTDKTPPKPTSTHPTIAELRAPLPVPSSSTKGTFSIYASRPINAPAHKLLKATLAHNQYSKWNAFAPDLTIKSQPAPVSDPAKALWRPDELQPGTVFTMRTYRDGSGLKSAQELGPATVTELRVETVEELGEGRAGYRVVWRNVALPGWCMTAERVQEFEDVAEGGALYTTWETMGGPLAWLVRLLYGRELVSMFAGWGAGLQGFVEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RNU4</accession>
    <name>A0A3D8RNU4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_06449</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RNU4"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01389">
        <property type="entry name" value="HMG-box_ROX1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.30.10:FF:000041">
        <property type="entry name" value="HMG box family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050140">
        <property type="entry name" value="SRY-related_HMG-box_TF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270:SF161">
        <property type="entry name" value="SEX-DETERMINING REGION Y PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10270">
        <property type="entry name" value="SOX TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HMG box" evidence="6">
        <location>
            <begin position="104"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="4">
        <location>
            <begin position="104"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="159"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="489"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW75628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="682" mass="75355" checksum="173B34855CB151CC" modified="2019-01-16" version="1">MSDLQRRGAPSFEIPRSPVSNSTDSSRRDSLRAFQAEKGSEPPTPNSQSPPFRLTRKRAASIDTDGANQPRIGDLALNTASPAGLPICDSAREQVCLCQPDPKIPRPRNAFILYRQHYQAQVVAQHPGLANPEISKIIGEKWRETAPEVKNDWKRLAEEEKQRHQRQYPGYRYQPRRAGKPNGVKPPSFSSPDEPIRCPKCNGRYISTPSTPLTPFTSAFGSAESRNDRLLPPFTPTMTPRTGDMSRYSQDARMDSPRTGPSHPINQRRGPYPPPQPLQTLRERAEDLSLSPDQKRRRFNEAPQRAYPSPSPISYTAPQGFSRNAPPMSAGGYRAAQQFTSQGPFTRSGTMGPPTQSSPLFQQPRHPYPTRANTFDESLRLPPLQTQLGNPAPATPQNPELRLETRDSQARSVEAMVMTIPYLNKIKVLSKISGPLPSPGPTSPAQDVRGAIIAVEGVDTNLVTEIGAFLNDALSREVGLAVKTWTAPLSSPVPRERSTPDADTGMTEASDEPSSNKDENPFIDYLGVISKWHSKSQSIVKHITTSSSPETSNPGALKRSPDILPKSLPVALLPEGYSLTTSDTYALRIPINDSYAPVDHWQWMATLWRGIVGPDLTVYVKKIRDKEEFETMTGVELRKDCAAIIVRVMEGTKLDEKSARRLAFEVSEYVRGVDSGFGGPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RP15</accession>
    <name>A0A3D8RP15_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">hydroxymethylglutaryl-CoA lyase</fullName>
            <ecNumber evidence="3">4.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_06521</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(3S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA</text>
            <dbReference type="Rhea" id="RHEA:24404"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:43074"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="4.1.3.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Metabolic intermediate metabolism; (S)-3-hydroxy-3-methylglutaryl-CoA degradation; acetoacetate from (S)-3-hydroxy-3-methylglutaryl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HMG-CoA lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.4" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RP15"/>
    <dbReference type="OrthoDB" id="1905920at2759"/>
    <dbReference type="UniPathway" id="UPA00896">
        <property type="reaction ID" value="UER00863"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004419">
        <property type="term" value="F:hydroxymethylglutaryl-CoA lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046951">
        <property type="term" value="P:ketone body biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006552">
        <property type="term" value="P:L-leucine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07938">
        <property type="entry name" value="DRE_TIM_HMGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000071">
        <property type="entry name" value="Hydroxymethylglutaryl-CoA lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043594">
        <property type="entry name" value="HMGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000891">
        <property type="entry name" value="PYR_CT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004283">
        <property type="entry name" value="PRK05692.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42738:SF7">
        <property type="entry name" value="HYDROXYMETHYLGLUTARYL-COA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00682">
        <property type="entry name" value="HMGL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50991">
        <property type="entry name" value="PYR_CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyruvate carboxyltransferase" evidence="7">
        <location>
            <begin position="38"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW75700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="354" mass="38003" checksum="F5E76FF0645A6268" modified="2019-01-16" version="1">MLRPLLRRSNFKPPQLRALATATDPTIQATPPHHNNRVRIVEVGPRDGLQNEKKAIPLQTKLRLIEKLAGTGLRDIEAGSFVAPKWVPQMADSDSILSHILATPPASTNSMRYSFLAPNMKGFQNAASILDQASTNRSSEDAEDPMIEISVFAAATESFSQKNLNCDIATSLERFRPVIQGARAKGLRVRAYISVVLGCPFEGYDVDPKKVAEIATDLLEMGADEIALGDTTGMGTAPRTSELLRAMQAAGVRTEDIAMHFHDTYGQALVNTAVSLEHGIRTFDSSVGGLGGCPYSPGATGNVSTEDMVYFVESLGMDCGDVDLEALSDVGQWISGEIGKENASSVGKALLGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RP86</accession>
    <name>A0A3D8RP86_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">p-loop containing nucleoside triphosphate hydrolase-8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_06587</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RP86"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF69">
        <property type="entry name" value="PEROXISOMAL LONG-CHAIN FATTY ACID IMPORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ABC transporter" evidence="8">
        <location>
            <begin position="263"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW75766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="509" mass="57652" checksum="8B5C6656B22C0B60" modified="2019-01-16" version="1">MTFYSLSALDDRIKNADQLITVDVSKFANSLAELYGNLAKPTLDMLIYNYSLSKSVGGEGLFFMSLLVQLSANVMRVLTPPFGRYVADEARLEGEFRFEHSRVIDYSEEVALYGGHEAEKDTLDKGYFTLIKHVNYILRQRFYHGIMEDFIIKYVWGALGLILCSVPVFFKIPGATVQTMGDRTESFVTNRRLLLSSSDAFGRVMFSYKEITELAGYTSRVATLLEVMDDIKAGQFEKTLVGDSTTDLELMKNRGKVIDSDEIEFIDVPIITPGGSVLAKALSFHMKPGDDMLVVGPNGCGKSSLFRILGGLWPVYGGTVRKPSLAQVFYVPQRPYLSSGSLRQQIIYPDSLRTMRSKGITDNDLLEILRVLDLDHLVGSFKDGWDAEAEWRDVLSGGLQQRVAMARLFYNRPKYAILDECTSSVTLEMEKIMYEHAKALGITLMTVSHRRSLWKYHSMILQFDGQGKYIFTKLDAEKRLRLEDEREELELQLRQVPEIERRIAELTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPF4</accession>
    <name>A0A3D8RPF4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_06595</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPF4"/>
    <dbReference type="OrthoDB" id="1703270at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11380">
        <property type="entry name" value="Ribosomal_S8e_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.168.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.168.20">
        <property type="entry name" value="Ribosomal protein S8e, subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001047">
        <property type="entry name" value="Ribosomal_eS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042563">
        <property type="entry name" value="Ribosomal_protein_eS8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00307">
        <property type="entry name" value="eS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10394">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW75774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="203" mass="23101" checksum="C2677028A83A1E06" modified="2019-01-16" version="1">MGISRDSRHKRSASGAKRAYYRKKRVFEAGRQESNTRIGSKRIHLVRTRGGNRKFRALRLEAGNFSWGSEGVARKVRVIVVAFHPSNNELVRTNTLTKAAVVQIDAAPFRQWYEAHYGVNLGRRRQQKAGQEVTEPEKKSKSVEKKHATRFAAQGKVEPALEKQFEAGRLYAVISSRPGQSGRCDGYILEGEELAFYQRQLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPV6</accession>
    <name>A0A3D8RPV6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_06914</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPV6"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF92">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="26"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW76093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="298" mass="33218" checksum="35E7CAF40209203E" modified="2019-01-16" version="1">MPLKLPATIGLECFLIFLPLVFIVGRIYVRLYKLNTVLNASDYFVFIGWFCLLGWAISTGLALKFNGYSWADSSSDELNGQLQRCLFAAEILFDIGLYFPKFSLLALYFVIIKDCFRKTRIALRVITTFIALASLTVMVLDFAICEPFSLQFSLIPGQCSSWTSWVTFDTNFVLNMVCDILVFALPFSFLGKMKISKKARIGLIGTFALGVVTILVGAMRYTLGVVYWDLPTTIVCTTAELCCALIVVSLPILRHLFGESVKEKGNRLINSSCQQQQVSSSENPVSDNCLALDMSSWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RQI5</accession>
    <name>A0A3D8RQI5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alpha-L-rhamnosidase six-hairpin glycosidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_07029</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RQI5"/>
    <dbReference type="OrthoDB" id="3455587at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017721384" description="Alpha-L-rhamnosidase six-hairpin glycosidase domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW76208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="755" mass="84291" checksum="A1D7EF52471C5428" modified="2019-01-16" version="1">MFYSLFPRYLLLVACVGAEALLLSSNDTLTIVDTAIQYNGESWTAYEDLTRTSGGLYFVSSSGKTRNFTRYLEQSYDPLPGTESVPFFLGLNQSDVNLALPDLLADALLANGEPVETHVRDAVPQVIFSYQSFVGNVQANDTMFVGAYGSTNNIGPLHTMDIASQSYFNYTYDGLVGGWMPTIRKVFRLSPTAENWLELIIFGDADSIEPFVIKTWFRTSLVINGKVQQQQFSREYPASPPARLEPTSEQFYAALLRSGDYWDSKVPDFSPLILPDQSWADITKHAFAIELLVRYGGDYPKYGFYDRNYAGSEYDGFQDIFTSSVMANLLWGRFDQAKKIIENYFIWFVSDTGDINMRGPEIPQYGLSLSLLTTYARYTGDTALLTKWKLKILAWVEILETLHDESLALQETDLNYGLIAGWSESDSCLSQNSSLYISPYWNNNANAARGLKDLSTIDIFSDNAVEWATRAETMINQTSSTLSKVIRFNMTPPYVPVLPKTSNTVRECMETESQCQQMWSHRVYAEMLQPGILPANLANQTINSMQAYGITSLGVVANVGLISPQSRDILGFISYGYAQALLLLGRVDEFILFLYSHRYHVHSRGQWIATEVAGTYGGTGDENPFCLPAEMTVPILMRLALVLEHPDDDVLFFGRGVPAAWLETGKEISIKQAPTRWGRVDFSVQMDTKAKKVHATVEFAGSPPAKLHVKIGLLQNQTIEAVMVNNQTGVLFTGEELVLDTSKFGNSVSIEGSIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RUW4</accession>
    <name>A0A3D8RUW4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_05695</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW77843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RUW4"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="6"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW77843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="579" mass="66586" checksum="3208A6A7FDCD7DA3" modified="2019-01-16" version="1">MRPASACKACRERKLKCSVQSKSQACQFCQAQNLECSLSPRDRVLARQEHRSKRILAAQPQSPIQSPKNDRHQGSNTAQLFQGAAKLNLKLPPIEVCNEIVDLYFQILHDKQHSLFHYPTFIRAQREGTVPPIIILAIITYTARFSNHSYFKGVERRYRGQEWSRAVKTMLNIQDMEVSITTMQACHLIGSLAISEGDSRMESMCSTIANRTAQLLGLPHRLSSDKLERELELRVWWSIYMFDVWSASSRGLPRTFTLDPTWEWPMDEVAFNQLTYGTAAHSHEDFDEDLGLRGIHPRKLSMWGQMIPLTDIKSDVFTLNEWTASQNHLTIDENRLLRSVAEISSKLAVWLHDLPPRLHNTPENLAYFVDLGFGTTFLALHVGYHYHSMLLYYQFLHEAESSGPSECLLSSSPYARDYAERCKFHATSISDILWTGSQTPRCECLWMLCGHMLVISSSVHLHTLLLGDDEELINQARNYLERNFELLLRLQSYWPGIFLSTTRLRVFHKACLRAARLNDTFRMDRWLLNMLQEHHEAIVNESTNDDQVDVTGDSLSAANMSAHSPSSTEFRSEMYSWIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RV32</accession>
    <name>A0A3D8RV32_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="13">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BP5796_05784</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:21249"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="13"/>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW77932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RV32"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1070.20:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000016">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1110.10:FF:000007">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000007">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009674">
        <property type="entry name" value="Rpa2_dom_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06883">
        <property type="entry name" value="RNA_pol_Rpa2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13 20" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="17">
        <location>
            <begin position="42"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="16">
        <location>
            <begin position="202"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="490"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase I subunit RPA2" evidence="19">
        <location>
            <begin position="595"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="14">
        <location>
            <begin position="702"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="15">
        <location>
            <begin position="1081"/>
            <end position="1145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF06883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RDW77932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1206" mass="134371" checksum="3412CB02759625B2" modified="2019-01-16" version="1">MAPSALSPTSTTWSHEFDTVRREKLFRNPPTDHSPYPLLQAAVAPHIESFNAVFEKDGLLAQGIKDIGTQTFLDGDDRLGPAGKNKLEIKIKDFYLEKSMLPASNKFSTKNREIFPAECRERHVTYRGKFSVRCEYRVNGGDPKEFVRELGQLPLMLKSNKCYLENASPAQLVQWKEESEELGGYFVVNGIEKLIRLLIVNRRNFPMAIERPSFQGRGPAYSKYGILMRSVRPDQTSQSNVLHYLNDGGVTFRFSWRKAEYLVPVMMVMKALVETNDREIFEGIVGSAGSKGSENTFLTDRVELLLRTFKNYGLYSKSQARSYLGERFRVVMGVPDTMSNYEVGGEFLRKIVLPHLGNVNVTDAQNNDKFRMLIFMTRKLYALVAGDCAVDNPDAVQNQEILLGGFLYGMIIKERLEDFIGTNLKLVLRDWLRKNPENNFTSQTFAKDFPAKIFGRTNENIGGALEYFMSTGNLVSPTGLDLQQVSGFTVVAEKINFLRFISHFRMVHRGSFFAQLKTTTVRKLLPESWGFLCPVHTPDGSPCGLLNHLSHKCKILTHACDASAIPKLVAELGVVSTGSSSTEESVVIQLDGRVLGFCTPKQALRIADTLRFWKVEGSHNVPKELEIGYVPASQGGSYPGIYIASAPSRMIRPVKYLPLDSEDMVGPMEQAFMSIAVTEPEIISGESTHVEFDPTNILSILANMTPFSDFNQSPRNMYQCQMGKQSMGTPGTAIRYRTDNKTYRLQTGQTPIVRAPLHNDYGFDNFPNGMNAVVAVISYTGYDMDDAMIINKSAHERGFGHGTIYKVKKIDLEEGGNKSRSSKNIKKLFGFAPGGLIKAEWKEAIDEDGLPRIGRRLGEGSLICAWHTVTSDASGKLVNRDGITHFEKYKETEECFVEEVRVIGNENGVEPAQAISVKFRVPRSPVIGDKFSSRHGQKGVCSQKWPSIDMPFSESGIQPDVIINPHAFPSRMTIGMFVESLAGKAGALHGLAQDSTPFRFDEENTAGNYFGHQLMKAGYNYHGNEPMYSGITGEELHADIYIGVVYYQRLRHMVNDKYQVRTTGPVTQLTGQPIKGRKKGGGIRVGEMERDSLLAHGTAFLLQDRLLNCSDYSKSWICKDCGTFLSVQPTVSAFAPKKKGTGVVRCRRCAVRAEAWSGKGEIWEDGEGQRWVGGENTTIVAVPGVLKYLDVELAAMGIKLKYNVGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RV72</accession>
    <name>A0A3D8RV72_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_05824</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW77972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RV72"/>
    <dbReference type="OrthoDB" id="8120565at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="312"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="350"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="476"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="37"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW77972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="559" mass="60448" checksum="2E736F3B5D5A40AE" modified="2019-01-16" version="1">MHASGPSSHDALSKRRAQFAGPSGVKGLLQNKKMFAIAVFASLGGFVYGYNQGMFGQILTMTSFSNTVHPDSISNTVTRGLLTAILELGAWVGVLVNGYTADKLGRKLATVVGVVVFVVGVIVQACAKNADYIYGGRFVTGLGVGTLSMVVPLYNAELAPAELRGSLVSLQQLAICFGIMVSYWIGYGTNYIGGTGKGQSNAAWLVPICIQILPAFVLGVGIMFMPQSPRWLLSNGKEEESLRVLSNLRRLPKESELVQLEYLEIKAQHMFEVETSIAKFPDYQSGSLSDNFKLGFYAYASLLTNRSLRKRVFAAVMIMVFQQWSGINAILYYAAFIFQDLGLTGNTTSLLAGGVGGILLFLATIPAVLYIDQLGRKPVLIVGALGMGISHLIVAGLDGAYNKSWPSHVAAGWVAVVFVWIYQINFGYSWGPGAWVVVAEVFPLGVRAKGISIGASSNWLNNFAIGQATPPMVQHMGFGTFIFFGLMCFIGAAFIYFVVPETKNLTLEEMDEVFGDEAGNAMEDRIRLDRIYGELGLFSDSSFDESDHKFSAVGVETKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RV80</accession>
    <name>A0A3D8RV80_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_05702</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW77850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RV80"/>
    <dbReference type="OrthoDB" id="6846267at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43142:SF5">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="18"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW77850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="556" mass="62204" checksum="DCEC3283870FB52D" modified="2019-01-16" version="1">MDADSEVTLLHRQLSTTFKGVKHPFSSSDFPIAQFRGIKYGTISARFKQASLFDRYPEYSNTTAHGPACPQTPRSTSLEEALNGLSLNQIQATGVKGKGNVDEFECLNLVITVPQMAMGNSGLPVLIYFHGGGNYSGSNSSWFNDGANLVQQSMKIQKPIVFVGINYRLAAFGFLASQALRDDNGGTGGGNYGARDQHLAIEWVYRYITEFGGDPQNITISGESAGALGVQSQIHSLFPSHFSRAILQSSSLSSPALHYPQSLEEKNEIYAKLLAALHVNTVDELRKVPWIDLLNAYEICNGRNGLPELLLVDDEFISASWQKSFSFPSWNGKEVLIGDTANEGDVFRLLAMSVPDSKQPFDPEKLVLDICRDLSERQAADITHVYDILPSKSNTEIYNTVLELWEDLAFYHSTSSFVTSVKDNLGKAYRYVFEQLNPFSGGLFYGSSNHSLDLIYLFGSENTFRDLKSHEIENAMREKLQDRWIAFVYGLEPWPQSSVYEFGPGGATRQLSEKEFRSKRRVQHHEVLDTLEPRDHRHLFGISTSFLIQHSQYAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVA0</accession>
    <name>A0A3D8RVA0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">NADPH--cytochrome P450 reductase</fullName>
            <ecNumber evidence="18">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BP5796_05722</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">This enzyme is required for electron transfer from NADP to cytochrome P450.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="18">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="18">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="18"/>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW77870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVA0"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016126">
        <property type="term" value="P:sterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000036">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023208">
        <property type="entry name" value="P450R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF108">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000208">
        <property type="entry name" value="P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 18" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="4" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="15 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 18" id="KW-0521">NADP</keyword>
    <keyword evidence="12 18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="17" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="16" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="19">
        <location>
            <begin position="83"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="20">
        <location>
            <begin position="281"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRNR" id="PIRNR000208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RDW77870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="693" mass="78148" checksum="9347A93499BDDE89" modified="2019-01-16" version="1">MSKLFGTSHLAALDTLLIQTHIDDIIFILYAVVSYTLYHRYVKEKPDPYHHIWFDRPQSINGSCKTAESRNISTKLDENNKDGVIFWGSQSGTAETFATRLARDCRSRFGLEMLVADLSDYDPQSIGDIPTSKFAIFIVSTYGEGDPSDNAAQFVSWLASNGSISLSNLRYAAFGLGNSKYQFYNRIVDVVTQSMDTLGATMMMPVGKADDAQGATVDHFIAWKNALFKHFVEILGYGERPYVYEPAWKIIDDPSLDIIDLHTGDPVEGRSDRLTKNVATSSIQRLPIKSIHRLLSTESRNFIHVEIDIGDYPEMKYRTGDHLAVWPSNPQSEVDRLLKILNLEGSRQTPLLISAVEPSTQTKIPNPVSWETLFRSYLEICAPVSRETLISLSRFADCPSVRAGLEKLGADVQLYQKFCASRHINFGRVLEHFTTESNTWSKLPQSFLLESLAALAPRYYSISSSSIVSPKRLSITVAIDAVSIGNLTTGGLNTSYISAICTRGLSQSHDDESDFTLVDQGTKFYAQVRASKFRLPVLAKHPIIMVCAGSGIAPFRGFIAERTRLAQIGREVGKMMLFFGCRNEDDYLYREEFETIRQENPYTLEIILAYSRSNTGPKRYVQDEVAERKDELARLMTEHGGYLYICGSASMARDVTSRIGECVRDTLHWKRDKLDSWLAHTRRTHRWQEDVWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVD6</accession>
    <name>A0A3D8RVD6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA polymerase V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_05879</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MYBBP1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVD6"/>
    <dbReference type="OrthoDB" id="342531at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000182">
        <property type="term" value="F:rDNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007015">
        <property type="entry name" value="DNA_pol_V/MYBBP1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213:SF2">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04931">
        <property type="entry name" value="DNA_pol_phi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="717"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="722"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="763"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="807"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW78027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1011" mass="112109" checksum="1B25DE1B87E17CF6" modified="2019-01-16" version="1">MGSKRKRAPQDAGPAPNAKKMQKTPTGKSGESKKKSVAPIEVDTTSPFLDYPSPADHKREVQLYEMLGSEMAEERLVAAGAVITGLLGGDGVEEATLQRHLERRLFRGLASGRKGSRLGFSIVLSEILGQLFGTANLAAEKYAGLTFENVLAILVAKTKPDGDLSGQEEKDHALGLLFGLKGFVQAKILFSDESRWTTILDKLFDLAKKKPWTREECGWVIVQALEQMNKAQAEVTLEKLFEAGLAVTPEGVGIWITAKNQFPKMKFPTKPWGPTGNPLDRMQNLAKALKESSSGDGNSEKNPQANQTGSWNPKLHFVWTLVLARYVNAAQSKTPGIKSEFENFWKVTVDENLFSASASRERKFWGFLLFQKVLEEASAYQDLLSSVFSLNLVRCLINSVQDKDRFLNRAADKSLKVLHHAAESSPDLVIIFLPQLLANNGNYNFDKITKTKTVEKLLQLTNDDTATEIVETLLQPVLSVDSADSAKEPESRRQMFGDYLLNLIRRVDASSSPTWLKSTAFPKLFDLAYGTELACSPPLSDRTRTLFRNRLSSALTHVLSGLENCHYPCDLLSLSPDAVKMDDDITSAKDQATSTVAKLLKKSKKAKEPKEKAPLQALALLYALVIFQLYNGESEAVSILDELKLCYDKLIRHKDSEESDVEASEVLVELLLSFLSKPSALLRKVTQLVFSAFMSEITADGLKLMTDVLESSESLKGQQELFDQEPEDGDQMEDDSADEDDDDELDSDVEVVDLKVLNGHLDESDDDDDAEEDEDEEMEDVEDEEGKKLDDALAQALGTNRLGKEGLEEDSDSDADMTDSEMMELDAKLVEIFKQRKNEPNKKQEQKDAKETMVNFKSRVLDLLEIYAKKQATNPLAFGLLIPLLELIRTTKTKQLAEKAQSIIISFSKAAKSAKKSDETPEIDVSAQIKLMKAIHVEASQDPSHLFAKAASNASLLIASSLYRSDKENAKKIAKVYSNTQLEWLGGEIKMQAAFFHDWVNWIQGHASASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RX92</accession>
    <name>A0A3D8RX92_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_06306</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RX92"/>
    <dbReference type="OrthoDB" id="5422510at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42032">
        <property type="entry name" value="YALI0E30679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42032:SF1">
        <property type="entry name" value="YALI0E30679P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="120"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW78454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="494" mass="54781" checksum="F7D3A7E2D531966F" modified="2019-01-16" version="1">MTDNSSPAARSSSTASPSTPYRKTLPGDEPALLRQRPPPTRFATNGGDGPNLRRRSSTFSDYSLNEARRSFHETADDVLLPTPDGKDRMRHATSNWDSAPLAFALLPAIGGLLFKNGSSIITDIMLLGLAAIFLNWSVRLPWNWYHSAQAIRKKDEYSPETVLESDSDGDDALSFSQGSLDKVPEEEAEEKATPAPPRSNKRHPAHTEAASELYTYEVLALFSCFLFPVLGAYLLHTIRGQLTRPSEGLVSNYNLTIFLLASELRPMAHLIKLIQARTLHLQRVVSSNPYDNDSEKLSSSEIQAMVQRIADLEARSLSTETPEAPNKKPVEQALTSKQTSILTTEVRRTLQPELDALNRAVRRYEKRATLQALQTEGRLQDLESRLNDAISLAAAAANGGQRRHSLSAMIIEWSAAMVVLPLQAFGTLASLPFKTAVVVLNLGKTAVIGKKVPVMSEKKMRRERERDREVMSAKYAMHNGRMGLDRLQGRVTRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2K0</accession>
    <name>A0A3D8S2K0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">18S rRNA factor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_05220</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF2/ABP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2K0"/>
    <dbReference type="OrthoDB" id="287393at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034462">
        <property type="term" value="P:small-subunit processome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12263">
        <property type="entry name" value="RRM_ABT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:001147">
        <property type="entry name" value="Pre-rRNA-processing protein esf-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039119">
        <property type="entry name" value="ABT1/Esf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034353">
        <property type="entry name" value="ABT1/ESF2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311:SF7">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="RRM" evidence="11">
        <location>
            <begin position="113"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="257"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="257"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="302"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW80522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="324" mass="36761" checksum="6825FE4D73C4E271" modified="2019-01-16" version="1">MATRKHNDFLDADQSEDDGSQGYNSDVEDLRKGGRSAKRRKVDSGASDDEGADSDLEEELPEDEEIEASNDKATAEKESKPKRLRRSAELPGVDKPLTKKNLVATEKARKRSGVVYLSRIPPFMKPSKLRSLLEPYGAINRIFLSPEDPASHSRRVKNGGNKKRSFTDGWVEFVNKADAKHACELLNARIIGGKKGTYYHDDVWNLLYLKGFKWNSLTEQIAAENAERASRMRAEISRTTKENKEFVQNVERAKMLEGMEAKKAAKRRKDDEDSPDVKEPKDDAVAKQRKGGERARQFKQTEVAKKRKPEDQPEQVKRVLSKIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2Z8</accession>
    <name>A0A3D8S2Z8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_05370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2Z8"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW80672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="234" mass="23589" checksum="C5959E0EA58D9D26" modified="2019-01-16" version="1">MLKNTILARTGTANNSGAADNSGAADNSGAANNSGAADNSGTADNSGATNNSAAWDNPDTPSGAWDNPDTPSGAWDNPNTSSGAWGTGTGGNSAAWDSFDKSSGAWGTGTATVEDVPVPASGPAPPRPVFGPEPPSGFPSGNGPAPPRPVFGPEPPSGFPSGNGPAPPRSEFDPDDVDLPPDDDPVWQSETGKIWLRTTRDLHDILRVANDSLSSAAAKRDGKDKDKDNNNGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3J9</accession>
    <name>A0A3D8S3J9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Nucleoside transporter family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_05585</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3J9"/>
    <dbReference type="OrthoDB" id="2116389at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015851">
        <property type="term" value="P:nucleobase transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000002">
        <property type="entry name" value="Purine-cytosine permease fcyB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026030">
        <property type="entry name" value="Pur-cyt_permease_Fcy2/21/22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806">
        <property type="entry name" value="PURINE-CYTOSINE PERMEASE FCY2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31806:SF8">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G03000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002744">
        <property type="entry name" value="Pur-cyt_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="101"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="255"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="287"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="380"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="484"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR002744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW80887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="514" mass="55226" checksum="2FEA9249587EF865" modified="2019-01-16" version="1">METPAHDSADIEKGQAPLETSIDQDSATSKNVATTDLPSSNKPAWKTLLASAFVEARGIDRVMPDERQQVSVFGYMQMLLLWFSANLTANNIALGFLGPSAYGLSFLDTALCAVFGSIVGAMGAAYTGTFGPVSGNRTMIIARYTMGWWPSRICVLLNIVIMLGYGMIDSVIGGQILSAVANNNMTVIVGIIIVALITWVVTVFGLPIFHVYERYAWAPQMAVVFILIGVAGPNFDVTYASSGNSATVIGDRISIFSLFVSAGIAWAPAGADYYVYYPENTPKYLTFLLTSLGLGLSTMFAYLVGAGIASGIETTPAWSDAYEISSGAVLVAAFDGLGGFGKFCGVILALGVIANNVPGTYSAGLGFQCLGSWPKKVPRAVWNTFGAIVYTICAAVGRNHLYDIFENFLALMGYWVTIWLTITLEEQFIFRRKIGYNWEDWDNKAALPIGLAALAAFLIGWVGAVLDMDQIYFVGPIAKLVGDYGADLGIFVGVGFAAITFPPLRFLEKKFIGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3W1</accession>
    <name>A0A3D8S3W1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">pyridoxal 5'-phosphate synthase</fullName>
            <ecNumber evidence="7">1.4.3.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">PNP/PMP oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BP5796_05646</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>pyridoxamine 5'-phosphate + O2 + H2O = pyridoxal 5'-phosphate + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15817"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:58451"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>pyridoxine 5'-phosphate + O2 = pyridoxal 5'-phosphate + H2O2</text>
            <dbReference type="Rhea" id="RHEA:15149"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:58589"/>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
            <dbReference type="EC" id="1.4.3.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxine 5'-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the pyridoxamine 5'-phosphate oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.5" evidence="7"/>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3W1"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="UniPathway" id="UPA01068">
        <property type="reaction ID" value="UER00304"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004733">
        <property type="term" value="F:pyridoxamine phosphate oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008615">
        <property type="term" value="P:pyridoxine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.110.10:FF:000010">
        <property type="entry name" value="Pyridoxine phosphate oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01629">
        <property type="entry name" value="PdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000659">
        <property type="entry name" value="Pyridox_Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019740">
        <property type="entry name" value="Pyridox_Oxase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011576">
        <property type="entry name" value="Pyridox_Oxase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019576">
        <property type="entry name" value="Pyridoxamine_oxidase_dimer_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00558">
        <property type="entry name" value="pdxH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004231">
        <property type="entry name" value="PRK05679.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851:SF0">
        <property type="entry name" value="PYRIDOXINE-5'-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10851">
        <property type="entry name" value="PYRIDOXINE-5-PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10590">
        <property type="entry name" value="PNP_phzG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01243">
        <property type="entry name" value="PNPOx_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01064">
        <property type="entry name" value="PYRIDOX_OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="9" id="KW-0288">FMN</keyword>
    <keyword evidence="10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-0664">Pyridoxine biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase N-terminal" evidence="16">
        <location>
            <begin position="53"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridoxine 5'-phosphate oxidase dimerisation C-terminal" evidence="17">
        <location>
            <begin position="192"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00050700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00052480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00083138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF10590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDW80948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="269" mass="30982" checksum="6FE529A8A479C84A" modified="2019-01-16" version="1">MALHPPQETSKLIFAPANDKTNAQADQYTKGALERTQLDANPLTQFHSWFSHAQQHGVHQPETVCLSTASLPSGRVSARMVYLKELDPKGFVIYSNFGTSKKAADVASNPWASLTFWWRELERQVRVEGRVERLTSAESQVYYDTRIRGSRIGAWASQQSRVLKGREELEQQVKEIEEKFEGQEKIPVPEFWGGLRIVPEMVEFWQGRESRLHDRFVYSKEGEEWKIERADRTHFSSLLAKAALLPSSYIDECFDAGWLTFRAEDERKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S958</accession>
    <name>A0A3D8S958_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative PRM10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_04397</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ThrE exporter (TC 2.A.79) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW82906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S958"/>
    <dbReference type="OrthoDB" id="413008at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010619">
        <property type="entry name" value="ThrE-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051361">
        <property type="entry name" value="ThrE/Ser_Exporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024528">
        <property type="entry name" value="ThrE_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31082:SF4">
        <property type="entry name" value="PHEROMONE-REGULATED MEMBRANE PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06738">
        <property type="entry name" value="ThrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12821">
        <property type="entry name" value="ThrE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="570"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="593"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="621"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="660"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="727"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="750"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="775"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="844"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/serine exporter-like N-terminal" evidence="8">
        <location>
            <begin position="438"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="domain" description="Threonine/Serine exporter ThrE" evidence="9">
        <location>
            <begin position="707"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="319"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="327"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="343"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW82906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="875" mass="94430" checksum="861547C74A7F3D5D" modified="2019-01-16" version="1">MSSDYMTASEGRASGHEQGYSELSGSPCATDSASPSRPSSALGHAVPKRSRVRFNSTSEANDSTNTRSQFPLRDRSESPPSASSLLALPKKSKASPAHSRNNSVTRLQRHTPESEKTNPFDDPLPSPVLRPRPSVLRKESVNSYNGDDVPDEAEEHNEKAFSALAAQERAQRIASLVGSHSAPASRRTSIDSEVDDDYEPPEKRTGLPVRIDDIPLINIDRQRTDGAGYDVDDELLEEREPTAATSSSLAHKLVRAHTTKYLNPKGVRMADPAPTGLVSGQVTPTEDQRDIEEYVPRPTHYRGGVLSSLLKLYNAPQNGGYGKMDSRSGTMSGSPSQAGTQLTTPGSSGTATPSRQKQAKWYNHKNQSQDTLAGLIEASAILGAQGGHAKPQRPGMGKRTHSGKLLDQAINRLNTRPRLEDEIRITVHIAETLSRHKYILKLCRALMSYGAPTHRLEEYMTMTARVLEVDGQFLYIPGCMIISFDDASTHTTEVKLVKSVQGVDLGKLKDVHEIYKEVVHDVIGVEEATQRLDAVITKKPKNNPWVLVLVYGFASATVGPFAFEARLIDMPIAWILGCLLGTLQLIVAPRSNLYSNVFEISAAVLTSFLARAFGSIRGGDLFCFSALAQSSIALILPGYMVLCGSLELQSKSMVAGSVRMVYAIIYSLFLGFGITIGTALYGLFDPHATTATTCPNPITGLYKWPFVPLFTLSLTIINQAKWKQTPVMLFISFAGYIVNYYSAIRFPSSAQLSNTLGAFAVGVLGNLYSRVRHGVAAAALLPAIFVQVPSGLAASGSLLAGLSSAESITNSTSNGTSHINGTSSVTVTTSEDLNTIVFNVGYSMIQVAIGITVGLFLSALVVYPLGKRRSGLFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S9Q0</accession>
    <name>A0A3D8S9Q0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_04568</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S9Q0"/>
    <dbReference type="OrthoDB" id="5578001at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017800954" evidence="2">
        <location>
            <begin position="27"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="242"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW83077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="369" mass="40501" checksum="51047949A8C79A16" modified="2019-01-16" version="1">MTAIAISPLSVQQLLLPLLSSLPTAAVAPSPPTALLPILSPILRQRVQLLSQGSPDPWLSLLCYDSAKAAKLQEVVKSDRFEPHPVSGEVEVDWDSDVEVRYKRQDEETLHALVALREMDLAVNCVWCTGDQEGGGDGWRVGEVKALEDSEGEELQKSIAEAEEAFKAAAAAKRDGYLIIQYGEKEVEEEEEDDDDDYWAQYDNTPARTPAPQHSPAPTQQNGASAGDEDSYYAQYASVQPAMDNHDPDEDIPEGVETSLGPQDHTHASEMPERVPEYSYEATEPALSAAELAHPRPGSSSSGEDTVARLEKEAARETESREETGIKQHIGTSIKSLYRLARVAGIERSEFDRLVKTELECLALMDEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAT1</accession>
    <name>A0A3D8SAT1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">DNA topoisomerase</fullName>
            <ecNumber evidence="3 7">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_04871</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3 7"/>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAT1"/>
    <dbReference type="OrthoDB" id="430051at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.290.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.140:FF:000005">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF21">
        <property type="entry name" value="DNA TOPOISOMERASE 3-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="9">
        <location>
            <begin position="4"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="10">
        <location>
            <begin position="168"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="529"/>
            <end position="556"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW83380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="651" mass="72718" checksum="DBDA556038DBD562" modified="2019-01-16" version="1">MVTKILCVAEKSSIAKAVAGHLSGGRVETSNTGNTYIKNYKFQFDFGRTWGHCEVCMTSVSGHLSAVDFASEYKNWSHPPPESLFGAPIREFVPEDKSAIAQNIAAQARGAKALFIWTDCDREGEHIGNEVKTEALKGNRRLQVKRAKFSNIERAHILQAARNPIDLDDRQVNAVATRIELDLRIGYAFTRFQTNLLRTLGGPLAEAMISYGSCQFPTLGFVVDRYWRVKNFVPETFWSIKVTQKREGINVVFNWKRNRLFDRATVIILFERCLDAKRAKVTKVTEKGTRRIKPLPLTTVELQKMATKYLRMNSQQAMTVAETLYNKGYISYPRTETDRFDKEMDLKALVQKQIQDNRWGEFANNLMNGGFNQPREGRHDDKAHPPIHPVTYCAPGGLSADEGRLYEFVTRHFLACCSEDAKGAQTDVEIEYGDESFHTHGTIVLERNFLDVYVYQNWTNSTMLPKFTLGEVFEPTEAMITEGKTTAPGYLTEPDLLALMDANGIGTDATMAEHIAKIKERVYVFTRPRGTNAAGGDSQDDAPAAGRGRSGGRAGAVGARGGAGIDEFIPSSLGVALVDGYDQIGLESSLSKPFLRKEMELKMKAICEGRATREDVLQESLRQYKRVFMDCKEGSAVLKSSCRRFVLNGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SC93</accession>
    <name>A0A3D8SC93_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_04879</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ING family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SC93"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15587">
        <property type="entry name" value="PHD_Yng1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF94">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="769"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="207"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="272"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="504"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="465"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="518"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="571"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="657"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="772"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="774"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="785"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="790"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="796"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="799"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="814"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="817"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW83388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="836" mass="90954" checksum="80D6CB0607312DCA" modified="2019-01-16" version="1">MGSSPARRWLDEGVWSCRIKLPRSQIDPRPQPRQGIILSNNDDAGDMPATTASMDVPLDTTSPRHKEQIAEALQNLPSMNHSMGPLNMPMGPDAQATITDFLDFTEYLPSDMIRSLTLVGNLDRGHSKASVLSQDLLKTYAMLPGLPVDDRPKPLKLREDVSENINESVRSRNMSHAEASRMAESVDRHLARAITINAKLQAMLENYPTSRNPSPEPQKSRSPQLSRITKPKITLRLDGSKQPENGGPKVRRRRVPRITVPGEVLAPYELDYDSYGTDTGISSDDERTPRATPGRSLGGPVIKLKINNNRAPKQQKVPKPPRPPRQPGMGTNVHSAVAGISTSNALAKLKPPPDDAVPGSPDAPWLQLTAWELAKLRKRMKKNAVWSPSDTMISRELKTLGRGIEAYRAAKQQADASGETLEHAIQPLIDGDDGTRVYNEGAISMDTLEKDEVQLSNRGMKLNEAKKLKRENQAKELAKQAAEEAEQSARKMAKAAAAVKDLFGESDPANEKKGLAKTPKKSAPKKRKRGSEEASGIIEPEQADTVETPKPVLPQAKKMKTETPIPVPQPMASTGTSSGTPTVESAPSVFSDGLPATEPTPAPAPSSPKKSSTPILPPGTVKKDTKKPQPIRTSQRQASAAPPTPAPEEPILKRPTSARSNLSRPSSRGKAASLEPAAVVSRDRPRRASTVHNTPAPEPRQPANRRAKRPPPGTITGGAGIEGAKAVSKRNTAPKKKGSKRQKDENSGIVMEVMDEVDDEGNIIDPNEPRYCVCNRVSFGTMIGCESVDCEKEWFHLECVGLTDIPSRTTKWYCPDCRVKLNLGERGEVTARGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SGU5</accession>
    <name>A0A3D8SGU5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Histone deacetylase</fullName>
            <ecNumber evidence="2 10">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BP5796_03838</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-acetyl-L-lysyl-[histone] + H2O = L-lysyl-[histone] + acetate</text>
            <dbReference type="Rhea" id="RHEA:58196"/>
            <dbReference type="Rhea" id="RHEA-COMP:9845"/>
            <dbReference type="Rhea" id="RHEA-COMP:11338"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="3.5.1.98"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the histone deacetylase family. HD Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2 10"/>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SGU5"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033698">
        <property type="term" value="C:Rpd3L complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070210">
        <property type="term" value="C:Rpd3L-Expanded complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032221">
        <property type="term" value="C:Rpd3S complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000001">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="15">
        <location>
            <begin position="41"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="399"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="440"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="316"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00061569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR037913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDW85513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="455" mass="51044" checksum="635DC9A8BDA53C7F" modified="2019-01-16" version="1">MASKSFAPLDDPLRSSTGRSKKRVAYIYDSDIGNFAYETGHCMKPHRIRMAHSLITNYGLYKKMELYRAKPATAAEMTQFHTDDYIKFLHLVTPENASTFKKEQDHFNLGGDCPIFDGLSDFCGISAGGSMEGAARLNRKKCDIAINWAGGLHHAKKSEASGFCYVNDIVLGILELLRFHPRVLYIDIDVHHGDGVEEAFFTTDRVMTVSFHQYGEFFPGTGELRDIGVGKGKHYAVNYPLRPGISDESYKGIFESVIGKVMEYYRPDAVVLQCGADSLSGDRLGGLNLSSRGHANCVKFVQSFNLPTLVLGGGGYTIKNVARAWAFETGVLLDVPMDPALPFNEYYGYYGPDFMLEVKASNAPNLNTDDYLNKITTSILENLKKVAFVPSVQMTEVPRKSLGISDEEEARENDRDDDEHKDVRQTQHRMDKMVSKNNEYYDDSEEDEDYGQPHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SGU9</accession>
    <name>A0A3D8SGU9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Vacuolar protein sorting-associated protein 27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BP5796_03902</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 12">Component of the ESCRT-0 complex composed of HSE1 and VPS27.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Endosome membrane</location>
            <topology evidence="2 12">Peripheral membrane protein</topology>
            <orientation evidence="2 12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the VPS27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SGU9"/>
    <dbReference type="OrthoDB" id="957735at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033565">
        <property type="term" value="C:ESCRT-0 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032266">
        <property type="term" value="F:phosphatidylinositol-3-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043328">
        <property type="term" value="P:protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15735">
        <property type="entry name" value="FYVE_spVPS27p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21385">
        <property type="entry name" value="GAT_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1940:FF:000001">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000161">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017073">
        <property type="entry name" value="HGS/VPS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002014">
        <property type="entry name" value="VHS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049425">
        <property type="entry name" value="Vps27_GAT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47794:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00790">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21356">
        <property type="entry name" value="Vps27_GAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036956">
        <property type="entry name" value="Hrs_Vps27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00288">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50179">
        <property type="entry name" value="VHS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0967">Endosome</keyword>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="VHS" evidence="16">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="15">
        <location>
            <begin position="120"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="182"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="289"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="481"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="573"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="617"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="635"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="657"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDW85577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="686" mass="75341" checksum="05462FC157E4FF4D" modified="2019-01-16" version="1">MRSLKRRIGNKNPNFQLSALNLTDTCVKNGGSHFLVEIASREFMDNLVSLLKAYGGAAVNDDVKNKILELIQGWATATEGRSELSYIGETYKTLQKEGFHFPPKVDVASSMLDSSAPPEWIDSDVCMRCRTAFSFTNRKHHCRNCGNVFDQQCSSKTLPLPHLGILQPVRVDDGCYIKLTDKSSKSGGSFAAERSPTHVSHRHKSQSMQPRNARVDDGFDEDLKRALAMSLEEVNGHAGAGYVPQAKLQETPKPVAQPINGTSNKSASKPVEDDDDDLKAAIAASLADMEEQKKQHSASMKQQAETSDSKSAAPFVLPKNDYELTPAESEDINLFSTLVDRLQTQPPGTILREPQIQELYGSVSSLRPKLARTYGETMSKHDTLLDLHAKLSTVVRYYDRMLDERLSNTYNQHTIGGYNLPPQRTSSGIYPSISSNVASRQNGVESFYTGNPNPEPYGRPQSMYSYAQPPQQYAFDKRASIANPGYPTPDLRSEAYNHFQPDQPTTQLQRTGSWQPTDKSPVQVPSHPPGYAPEGPLQQQYAPSAPLQPATPSADPNAAFYYGASAPPPQQIPEANQAQYSSQSPQQFHSSVQHSAPPTQYPQPLSQEQQAPPPPQAAISPPAAQQGPPQSPYWQQQNAAAAAAPAQPYQTPGQTYGGYTQESFPTAPQHNIQPQPKLVEESLIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SGV7</accession>
    <name>A0A3D8SGV7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_03827</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SGV7"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF7">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="75"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="236"/>
            <end position="239"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW85502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="561" mass="61312" checksum="C8285404C3ABA703" modified="2019-01-16" version="1">MTNWEALAKEKRDSVNALLPKPWLLPSPVPTVQEQRDVTGKYIQQFLSPQEVEITETDAVGIVAKTTSGEWKSKDVAEAFCHRAALAHQMVSCLHEIFFDAAIADAEKLDEYFAEHKKPIGPLHGLPVSLKDQFHVKGVETHMGYVGWIGTFEGKKGTGKERVFESEMVKELRSLGAVLFCKTSVPHTLMAGETTNNIIGYTWNPKNRNLACGGSSGGEGALIALRGSPLGFGTDIGGSIRIPSLFNGLYGIRPSSGRLPYEGMANSMDGQNTILSVVGPIATSVASLQLAVKSILSTEPWLHDPLVAEIPWRDEQEQAVLDAVKAGQGGQLAFGIRRTDGIVQPLPPVRRAMDIVVKTIEKLGHKVVEWEPPAHERAIELAFKTWIFDGGEDVHGAFALSGEKVVPPIASVYGDKPVKQHTASEIAAVNVGKRAYQKEYMEYWNSTSSITGTGRPVDAIVTPGAAFPAARPNMYDYYAYTTWVNLLDYSATTLPVTVVDKNIDVFDEDYTPMNAQDEKMHKSYDPEIFDGAFVGVQIVARRFQEEKVLALTKILSDGLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHS2</accession>
    <name>A0A3D8SHS2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Carbohydrate-binding module family 18 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_04147</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHS2"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd11618">
        <property type="entry name" value="ChtBD1_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00118">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001002">
        <property type="entry name" value="Chitin-bd_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052210">
        <property type="entry name" value="LysM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997">
        <property type="entry name" value="AM15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34997:SF1">
        <property type="entry name" value="PEPTIDOGLYCAN-BINDING LYSIN DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00187">
        <property type="entry name" value="Chitin_bind_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00270">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54106">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50941">
        <property type="entry name" value="CHIT_BIND_I_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017810796" description="Carbohydrate-binding module family 18 protein" evidence="4">
        <location>
            <begin position="20"/>
            <end position="1179"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="272"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="463"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="6">
        <location>
            <begin position="653"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="5">
        <location>
            <begin position="731"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="5">
        <location>
            <begin position="803"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="5">
        <location>
            <begin position="869"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="domain" description="Chitin-binding type-1" evidence="5">
        <location>
            <begin position="934"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="747"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="823"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="889"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="954"/>
            <end position="968"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW85822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1179" mass="120632" checksum="8A558226CCB3B4F8" modified="2019-01-16" version="1">MSLFSIFFVAATLLGACSAHDGLSGFAETEEACYAAGVEEISCMNSFFPTNTVLTIPSACIITVTSAPTSIATCYTVTSMITPPPTRLPYIEVETRVVVPQPPAQTEIDYITVTVSSFETFCPSPTTFTWGTRTYDITAPTTITIMDCPCILTKPVVTTPPSPSLSQSRDVAMYTTITTSDFTTELPSPTAPFVTTYGTRPFTITDRTTITVTDCPCTLTRPITSTRPVMISPSTPKIGPSGLSTAEGPMPTCSSVMPPAPTPIGTTECCTEWYIVVEGATCATIELEFDITFAELQALNHVLDNMCSNLVLGYSYCVVGQIEICPGCPPCQGCPPLPASSSIVILPSLSGGSMSFDRPSLRTTGAFPTVTPLPGISMSMTDYTTAISPSSSIPMPGSFLATTPVPSGLFVSGYGSVSSISTGSAPVIPSAGSVTSMFPVASCSASVPVPSNVAPETTGCCIEYYEALEGDSCTSIELRFNITLGEFQALNPGLNADCSNLLSHVTYCVHGQIEVCPGCIPCRGCPPLPLSSSATVLRMPSNSPNTMSAPSVPTTPVSPSGTACAMTGAITSILGMGQPKASLYCSSYLSQLTPTSTINLAESTVPVAYVTTTVGAMLTSGTREAVSPTAIPSCTAVPAPAETRAGATENCCEWYIVVANDSCTSIDTRFGLTFAEFQDLNPDIFCDCYNLLQSFAYCVKGSPSSVKPSDSCPAYMATSTATVLPSTPATGPYCGPLGQGYSCASACCSQHGYCGVDSEYCGTGCYPDYSGSGLCSQFSSSSVGISSTTAKTAAPVSTSVGIAPNCGTQGNGVTCSAALGGECCSEFGYCGTDNAHCGVGCQALFGNCYSRTSSVSFSSAPTATSVGLPPNCGTQGNGVTCSAALGGECCSEFGYCGADNAHCGVGCQSPFGNCYSKFSSVSSSAPTATSVGIPPNCGPSANGAVCSAALGGECCSYYGYCGTGGAHCGAGCLSLFGQCSLSVFASSSIIADTATPVLATTTVRPAITTTTHTPSEISSACSCILDLPSATVNQIDPYSAITGSVIVPTATVSLPNCDNPGVCGVFSSHICGGSCADVGDSQGGICAADTDGVGWCISKYSMCGNACNTNADCDSKVCLMNTCCKGGNTCLSPDNQSLCTNNMAARRLFAKRKATYGTIFNDDIPVVGDTPLIDKARIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHS5</accession>
    <name>A0A3D8SHS5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Pentafunctional AROM polypeptide</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-dehydroquinate synthase</fullName>
                <shortName evidence="21">DHQS</shortName>
                <ecNumber evidence="21">4.2.3.4</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-phosphoshikimate 1-carboxyvinyltransferase</fullName>
                <ecNumber evidence="21">2.5.1.19</ecNumber>
            </recommendedName>
            <alternativeName>
                <fullName evidence="21">5-enolpyruvylshikimate-3-phosphate synthase</fullName>
                <shortName evidence="21">EPSP synthase</shortName>
                <shortName evidence="21">EPSPS</shortName>
            </alternativeName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">Shikimate kinase</fullName>
                <shortName evidence="21">SK</shortName>
                <ecNumber evidence="21">2.7.1.71</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">3-dehydroquinate dehydratase</fullName>
                <shortName evidence="21">3-dehydroquinase</shortName>
                <ecNumber evidence="21">4.2.1.10</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="21">Shikimate dehydrogenase</fullName>
                <ecNumber evidence="21">1.1.1.25</ecNumber>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="28" type="ORF">BP5796_04039</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28 29">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20 21 22">The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21256"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57701"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="EC" id="2.5.1.19"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:21257"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:21968"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="EC" id="4.2.3.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 21 22">
            <text>shikimate + ATP = 3-phosphoshikimate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13121"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:145989"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.71"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21 22">
            <text>shikimate + NADP(+) = 3-dehydroshikimate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17737"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:36208"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="21 22">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="21 22">Binds 2 Zn(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 4/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 21 22">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 6/7.</text>
    </comment>
    <comment type="subunit">
        <text evidence="21 22">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 21 22">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the 2nd section; belongs to the EPSP synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the 3rd section; belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the 4th section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21 22">In the C-terminal section; belongs to the shikimate dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="22">In the N-terminal section; belongs to the dehydroquinate synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="21">In the N-terminal section; belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.3.4" evidence="21"/>
    <dbReference type="EC" id="2.5.1.19" evidence="21"/>
    <dbReference type="EC" id="2.7.1.71" evidence="21"/>
    <dbReference type="EC" id="4.2.1.10" evidence="21"/>
    <dbReference type="EC" id="1.1.1.25" evidence="21"/>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="197068at2759"/>
    <dbReference type="UniPathway" id="UPA00053">
        <property type="reaction ID" value="UER00085"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003856">
        <property type="term" value="F:3-dehydroquinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004765">
        <property type="term" value="F:shikimate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08195">
        <property type="entry name" value="DHQS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01556">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00464">
        <property type="entry name" value="SK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000135">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001256">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.65.10.10:FF:000007">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.65.10.10:FF:000008">
        <property type="entry name" value="Pentafunctional AROM polypeptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.10">
        <property type="entry name" value="Enolpyruvate transferase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00210">
        <property type="entry name" value="EPSP_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03143">
        <property type="entry name" value="Pentafunct_AroM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00109">
        <property type="entry name" value="Shikimate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018508">
        <property type="entry name" value="3-dehydroquinate_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016037">
        <property type="entry name" value="DHQ_synth_AroB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030960">
        <property type="entry name" value="DHQS/DOIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056179">
        <property type="entry name" value="DHQS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001986">
        <property type="entry name" value="Enolpyruvate_Tfrase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036968">
        <property type="entry name" value="Enolpyruvate_Tfrase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006264">
        <property type="entry name" value="EPSP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023193">
        <property type="entry name" value="EPSP_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008289">
        <property type="entry name" value="Pentafunct_AroM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010110">
        <property type="entry name" value="Shikimate_DH_AroM-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000623">
        <property type="entry name" value="Shikimate_kinase/TSH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023000">
        <property type="entry name" value="Shikimate_kinase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01356">
        <property type="entry name" value="aroA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01357">
        <property type="entry name" value="aroB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01093">
        <property type="entry name" value="aroD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01809">
        <property type="entry name" value="Shik-DH-AROM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090">
        <property type="entry name" value="AROM/DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090:SF5">
        <property type="entry name" value="PENTAFUNCTIONAL AROM POLYPEPTIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01761">
        <property type="entry name" value="DHQ_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24621">
        <property type="entry name" value="DHQS_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00275">
        <property type="entry name" value="EPSP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000514">
        <property type="entry name" value="Pentafunct_AroM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01100">
        <property type="entry name" value="SHIKIMTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01028">
        <property type="entry name" value="DEHYDROQUINASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00104">
        <property type="entry name" value="EPSP_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00885">
        <property type="entry name" value="EPSP_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01128">
        <property type="entry name" value="SHIKIMATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 21 22" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="15 21 22" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="12 21" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 21 22" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 21 22" id="KW-0418">Kinase</keyword>
    <keyword evidence="16 21 22" id="KW-0456">Lyase</keyword>
    <keyword evidence="8 21 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17 21" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="13 21" id="KW-0521">NADP</keyword>
    <keyword evidence="9 21" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14 21 22" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21 22" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 21 22" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="3-dehydroquinate synthase N-terminal" evidence="24">
        <location>
            <begin position="80"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="domain" description="3-dehydroquinate synthase C-terminal" evidence="27">
        <location>
            <begin position="194"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="Enolpyruvate transferase" evidence="23">
        <location>
            <begin position="405"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="25">
        <location>
            <begin position="1293"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="domain" description="SDH C-terminal" evidence="26">
        <location>
            <begin position="1541"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="region of interest" description="3-dehydroquinate synthase" evidence="21">
        <location>
            <begin position="1"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate kinase" evidence="21">
        <location>
            <begin position="862"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="3-dehydroquinase" evidence="21">
        <location>
            <begin position="1055"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Shikimate dehydrogenase" evidence="21">
        <location>
            <begin position="1288"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for 3-dehydroquinate synthase activity" evidence="21">
        <location>
            <position position="263"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for 3-dehydroquinate synthase activity" evidence="21">
        <location>
            <position position="278"/>
        </location>
    </feature>
    <feature type="active site" description="For EPSP synthase activity" evidence="21">
        <location>
            <position position="822"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for 3-dehydroquinate dehydratase activity" evidence="21">
        <location>
            <position position="1178"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; for 3-dehydroquinate dehydratase activity" evidence="21">
        <location>
            <position position="1206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="49"/>
            <end position="51"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="86"/>
            <end position="89"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="117"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
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        </ligand>
    </feature>
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        <location>
            <begin position="142"/>
            <end position="143"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
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        <location>
            <position position="164"/>
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        <ligand>
            <name>NAD(+)</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="165"/>
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        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="182"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
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        <location>
            <begin position="197"/>
            <end position="200"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="267"/>
            <end position="271"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
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        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
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        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
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            <position position="290"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate</name>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="21">
        <location>
            <begin position="869"/>
            <end position="876"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00054455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="PIRNR" id="PIRNR000514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF00275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF01761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF24621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="RDW85714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1575" mass="170352" checksum="3394AAD858690B15" modified="2019-01-16" version="1">MGSSLPHNPTRIAILGKDDIIVDFDIWRNFVAEDLLSNLASSTYVLITDTNLAPLYVPVFKEAFERRAAQSDATPRLLTYAIPPGESSKGRETKAEIEDWMLSQKCTRDTVIIALGGGVIGDMIGYVAATFMRGVRFVQVPTTLLSMVDSSIGGKTAIDTPLGKNLVGAFWQPQRIYIDLRFLETLPVREFINGMAEVVKTAAIWDEVEFATLEDNAALLMETIRAKSTNTATRLDPIRDILKRIVLGSARVKAEVVSADEREGGLRNLLNFGHSIGHAYEAILTPQVLHGEAVAIGMVKEAELARHLGVLKPGAVARLVKCIASYGLPTSLADKRIQRLSAGKLCPVDVLLEKMAVDKKNDGQKKKIVLLSAIGKTHEAKASVVEDRAIRIVLSDSIEVIPGVPKTLKNEVVPPGSKSVSNRALVLAALGTGPCRIKNLLHSDDTEYMLTAIGKLGGATYSWEEAGEVLLVQGKGGDLKASPEELYIGNAGTASRFLTTVVSLCKPSSVSSTVLTGNARMKVRPIGPLVDSLRANGVEVSYLEKEHSLPLRVAASGGFAGGEIELAATVSSQYVSSLLMCAPYAKKPVTLRLVGGKPISQPYIDMTTAMMATFGIKVVRSETEEHTYHIPQGVYKNPAEYVVESDASSATYPLAVAAITGTTCTIPNIGSKSLQGDARFAIDVLRPMGCTVEQTDYSTTVTGPGRGQLKAIEEVDMEPMTDAFLTASVLAAVATGTTRIRGIANQRVKECNRIAAMKDQLAKFGVVCRELEDGIEVDGRPIDELQHPAEGIFCYDDHRVAMSFSVISVVAPKPVLIMERECVGKTWPGWWDVLSLSFHVELEGKEVGGPHAKHASSSLMPEQSLFIIGMRGAGKTTASGWAGKILNRPHLDLDIELERVVGMPIPDFVRSKGWDAFRTEELALLKRTIKEKPKGYVFACGGGVVEMPEARQLLSDYHKSGGIVLLVHRDTEQVMEYLKIDKTRPAYVEDMMGVYLRRKPWFQECSNFQYHSKGGEAGALSIAREDFARFLSLVSGASTHFEEIRDKKHSFFVSLTMPDITAAAHLLPTVAVGSDAVELRVDLLVDPDSTNGIPTPEFLSLQVAHLRSIVHLPVIFTVRTVSQGGRFPDDAHDEALKLYKAAVRMGIEYIDLEIAFPDELLQTVIDAKGFSKIIASHHDPLGQLSWKNGAWVQHYNRALQYGDIIKLVGSAKSLEDNFALAKFKAAMTAAHDVPLLAINMGAHGKLSRVLNGFMTPVSHPALPFKAAPGQLSAAEIRQALSLIGEIEPKAFYLFGTPIAASRSPALHNTLFQQTGLPHQYSRFETDRAQDVEEIIRSPNFGGASVTIPLKLDIIPLLDDTTDAVKVIGAVNTIVPTLEPDGKQQLIGENTDWLGMTHSLISASYLPTISTPPGSGLVIGGGGTARAAIYALKSLGHSPIYVVSRTPSKLTTMIASFPTEFNIVALSEIADAEAVPEVPGVAIGTIPADKPIEQNMREVLAVLFRHPKAAAGQRTLLEMAYKPSQTALMKMAMDAGWVAIPGLEVLSGQGWYQFQKWTGIKPLYSAARAAVMGDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SI09</accession>
    <name>A0A3D8SI09_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Lysophospholipase</fullName>
            <ecNumber evidence="2 9">3.1.1.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_04271</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a 1-acyl-sn-glycero-3-phosphocholine + H2O = sn-glycerol 3-phosphocholine + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15177"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16870"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="EC" id="3.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the lysophospholipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.5" evidence="2 9"/>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SI09"/>
    <dbReference type="OrthoDB" id="4084751at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004622">
        <property type="term" value="F:phosphatidylcholine lysophospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004623">
        <property type="term" value="F:phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002642">
        <property type="entry name" value="LysoPLipase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728">
        <property type="entry name" value="CYTOSOLIC PHOSPHOLIPASE A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10728:SF33">
        <property type="entry name" value="LYSOPHOSPHOLIPASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01735">
        <property type="entry name" value="PLA2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00022">
        <property type="entry name" value="PLAc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51210">
        <property type="entry name" value="PLA2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8 9" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="6 8 9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017496890" description="Lysophospholipase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="domain" description="PLA2c" evidence="11">
        <location>
            <begin position="28"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="636"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW85946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="677" mass="70512" checksum="8594CB825CD2E719" modified="2019-01-16" version="1">MRYSTSYALATASLVSSVLAGYAPAPTTCPSTSLVRAATGLSDDEETYRVARKAKADVTLASWLTSTNNAFDVSGELPALGLANSGGSYRAFLIGAGVYNAIDGDGGAGTSVSGLYQALSYHSALSGGAWLLASIMSHNWESVSSLLTLWEPAFAYGLFDPEGTAILQVFANITEDLALKEAAGFRGTLTDLWSRALSCQMLPGESCGVDNTLSAITSQTEFMWNNVPYPIITAQNVDLSGTSCLPTPTTAAVWEFTPYEFGSWDSSVAAFTPTKYLGSTVNNGVAESCFTNFDNLGFVLGTSSSLFNDLNYEVDNGVNPPLLADWCGSNSDTSAIGSEITTLIEEIYTIEYQTVADLFAQWPNPFYNSAASPLVSSQANLSMVDGGQSGQTDPIFPMLVPERNISVILVNDNAGDTSDNYPNGTAIYSSYLSAQAMGMTRMPFIPTPSVFVAENMTERAVFFGCGDSSVATIVWLPNAPLTAAGGGTSTNLLTYNTTMTESMIANGVAVMTQPDDIEWPTCLACVIMEGTGTTLPSECTACLAKYCYSTSTTTSASASATCTGTCTSTSIPTSTPISTPVYNSTSTPVVALISSSASTPISTPVYTSTYTPVVALISSSASTPISTPVYTSTSTPIVAPTSSSTSTPVVAPTSLPTSTTVVAPATVTDVVDDDTVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMS9</accession>
    <name>A0A3D8SMS9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">LNS2/PITP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_03311</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lipin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SMS9"/>
    <dbReference type="OrthoDB" id="4567at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009062">
        <property type="term" value="P:fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000063">
        <property type="entry name" value="Nuclear elongation and deformation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026058">
        <property type="entry name" value="LIPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007651">
        <property type="entry name" value="Lipin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013209">
        <property type="entry name" value="LNS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057124">
        <property type="entry name" value="Ned1-like_M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181">
        <property type="entry name" value="LIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181:SF12">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04571">
        <property type="entry name" value="Lipin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08235">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24565">
        <property type="entry name" value="Ned1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LNS2/PITP" evidence="4">
        <location>
            <begin position="446"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="96"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="340"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="653"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="658"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="721"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="753"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW87617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="787" mass="86275" checksum="4F6D842413C61CCB" modified="2019-01-16" version="1">MQYVRSISGSVSKTWNSINPATLSGAIDVIVVEQEDGTLACSPFHVRFGKFSLLRPSEKKVEFRVNNAKQDYAMKLGEGGEAFFVFETSDNIPEAMQTSPLVSPASSPPLVPDGLRREGSNLSEPDFLDLDITSRSRAGTFARSGSEEPPRRPGQLSSFTPLSSSPNFNSSRPDSGDWSAVTNGRHHTDEILPSSARTNTSDDTERDRQTRSLTPEMRTRDGASETLTERSASPPPLPTKEAIQRAIALSKQLSASNIPTQVTDTGDLMLDMTGYKSSDDDALRAEVIARKILSEELEGNYDIGALIGADENGNLWIYSSEEAKEVAAQRAVMAGIPSSQVLTSDAASDPGYHSDAESDSLSGPPIPSHRRAGSDSGPLSLETPPNTPPDSAAAGDPNRNYAKTLRLTSEQLKALDLKAGANPMSFTVNRATCTAYMYLWRYDVPVVISDIDGTITKSDALGHVLNIIGRDWTHIGVAKLYTEIVANGYNIMYLTSRGVGQADMTRTYLKGVVQESYRLPQGPTIMSPDRTIAALRREIYLRKPEVFKMACLRDIKNLFGPNRTPFYAGFGNRLTDALSYRSVSIPSNRIFTINSYAEVSLDLLSLNKLRYSYVNMREVVDHYFPPVNTLVKGGGEEYTDFTYWRDPVLDLDNFSASDSDEEADDDDDEDDDEDDEQGAGLGDSYISRDSIDDANEGSILSGSAMDDYDENEHMTSSMFEGDAEEEYEEDEATPGLESTTPQERDDREIPQPNRLQPATEQPGSRRDSNAEIISGVKNLSLADDKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SN20</accession>
    <name>A0A3D8SN20_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03409</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SN20"/>
    <dbReference type="OrthoDB" id="10278602at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW87715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="232" mass="26634" checksum="82CBB621B87F3C14" modified="2019-01-16" version="1">METSPDTHSFRRRAHRSLEDSSGFPAFPSYTGSQDLTLGHQIRSKDHMDRIALASATRKLYRQLEKSIKVYENLLKAYDADVAKIRKYADERTMEQLWFLKVEGRPDRGGLVEDGFSGTMVKMMETGSLLVECLCDVRRSTLDEYTRGTPKEQRQVEKSRRLYKQVGFAGDQILDLLHLSVKSEDYCKELVSDMQRLKTLVDPKDKALSYDDTTVESSAPWYTTSTEDIPED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SN81</accession>
    <name>A0A3D8SN81_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SN81"/>
    <dbReference type="OrthoDB" id="5386674at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="850"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="580"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="624"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="663"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="682"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="714"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="742"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="761"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="819"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="853"/>
            <end position="869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW87631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="949" mass="103797" checksum="13A8F251D93EF620" modified="2019-01-16" version="1">MTSINSNSGAAPSKRSSFRRMLDLEKKSKLDRMRASASFAVQSPSSAVPPIPTRLSYAPSSSQPQMLQTTRRAKTAPPSAPLPPNPILPVNTRLEQHMSVQRPGASPWEEPAFCASPAALTIEIPPRELDEDSDRSSICQSPGWGDAKERKRKHEAKEKRKKEKEKAEKDRLKVEKERAKKEKEKVKSDKDGREAKKLKKRSNNGPPTNKIFNRMAIPMERSVSAPVVVALAEEKASQGGSSKPSSSSSRRSSLEVGLKSLRSLTGSWKQNETPASLQELPADAEGFVGGLKLQNERDLALQDQIRKLTLDEPSAVLTGRPKKPVQMRSMSADAVSVGTGSKFHYLEFHPTMPPELSESELETDSFHDPASYAARASKQPAFNNEESSTSIMERKIRRPRKNRGLDEHEPMNNRNDSRQSLEERTGSRDGDTSQFPFDAQTTRRLSPTYNPESETLASHVDLDGSRGRKGSDTTNDARSIRRGRPVTAYHTERRASNATFNQTPQSANRSHQRCLSVQPDVANGWDSQQGNGETTMKSWGELGEGSARSRDSYHSFVAQSQILPPHQQQANLQGEDKSSKVYPSSPSFKSFKSAARAAFSRNSQVPPLPVAGLTGSIPGHHSRPSTTQSSADSQKALSKAERVLGETDLPAPRSMQQSRATKSQSSSLLSSSDGSILDEDSNITTPSASRPQSHQGEFSPSREPGHHASTAVDSIPPIAAASSSKHSEDRLGTSPIIEDDTDWQRPDLDGHNKKSSLNNISRRPSLTRSLSTPELQQDLSFLPPLKHQSLERSAKGKEKEVTRQQPSKAADEELGGTSLAHSASTTVPGQRPTLTKEDGGQYLQNARLNVLRTSPKSKPGSSGSTVGPKPGMDSIAKMFVVCCSCLYFHDLPSKVYECMTKPDNIVEDKDLGVTGQMTTMVRCPWCEHGMSTSCCSGILTTLQVIQKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SNV0</accession>
    <name>A0A3D8SNV0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_03656</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3182339at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022099">
        <property type="entry name" value="DUF3638"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022105">
        <property type="entry name" value="DUF3645"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046541">
        <property type="entry name" value="DUF6606"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051346">
        <property type="entry name" value="OTU_Deubiquitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367:SF34">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367">
        <property type="entry name" value="UBIQUITIN THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12340">
        <property type="entry name" value="DUF3638"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12359">
        <property type="entry name" value="DUF3645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20255">
        <property type="entry name" value="DUF6606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUF6606" evidence="11">
        <location>
            <begin position="26"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3638" evidence="9">
        <location>
            <begin position="2017"/>
            <end position="2238"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3645" evidence="10">
        <location>
            <begin position="2363"/>
            <end position="2396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2830"/>
            <end position="2849"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="588"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="2832"/>
            <end position="2849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW87962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="3103" mass="353520" checksum="7BAA6270B825773E" modified="2019-01-16" version="1">MTRSRNDTTVRRPPVLYSDIETSLYMVHHVFLPPKLPQKDDFASWLDSALADMVLDSLQEFSNLQNQHCATGSVASMVENFQAVHNESGHITQARLEETLAVLSRDESKVVALHVSAQNAGVILHRDPDVVIFEVFELSPDNKSVVSTKGRLQRSFPAFAVSVPLEEFSDQGFQTTLSQAISKMSTERIDEMQPKVKKAGEKQSETRDTTIPHLVTEHLVSFLRAVGEPVSTAAIRKNTREEVMWKDAKSPWRRSPMWLLLRVAMQLTFSRLSAGPLKSPYKPFMIFLMSRIIKLALTYSGIESDVIYAMNAKLSQRLLKVEDYREESWFSSVQNTMTRAQCHINSRWQSVMTESCPRLDLSALREINPPENVVHELPHLDELLHQLQGFSTSKMHSTFKAQGNFPSFDPAHLPRFTHLALNSLDQSFGLAALEAWVELHLEGWLNRHINMENTCVSLKDLIKAYHHEAGAKYAGNPEALSLMVLTIMDLWVACDKAACCLYKSLKQYDHEIAPSLLWSLLLPLKSQLNRVSSVESYLHSRATQINKTFASPFRKFGHWSSFAVRYFEQSPQHQQLLTNIEEKAHRQKADKVQELAKLNQTHRELMNRHESASCEYVQVTEYDIDGSPYEKTQHSSYCQKCAFLQQATSMRISLHEWPVSKESNKAKATVFELTVPPDFGAWRDVTHYMLQTVLGYKYESKIAMGSDYILQNDPGIKYFYQANIERVGIRSHTKPSTLTHRNPVSIPTTQASVCLANGLSYDYFDFNTGSLISPFVTTSELHAQCTFVLPTRSEALQKFIQRTPNEPNGPEPNEVIASLSECPDGMSVDEFRSFALLPLGYEIQWQNILSQLAIPSLDFAKVDTTFLFLQISQQIGPDNNSPSRASHEILSDECFSAALLEQLREAKRRVGENWESFQALAAFICLAARLLASTPFPNIHSDCLEYLASCRSLLFGWVTKLRGKVQSCTDDAQRAEFAARAVDLALICISSFGIDREHLHSVLCFTAEASVFLQCSITIQEHLLSIDLSRLSSANIFLARWRQLMYKAYPELVHLIVGLLDSCLNLAIKEFWADHTPCSKWQQLPEQNQYWLQSSSCSDDGSDSFSVHFNLLTAELLVNGAPLAKLPVQYENHAIYPILFGRSHIQVMPSSRPGFHFSSRCKYAGHLIHFGFLKNDMLLYAVNDDCTYSLVPPRVLSGYLPQAFVQDYVHWFDHQLQAVYFVPIKDPWSRNPHYWRLSNNGHGWILTKGDETLVNMQSRTAGVFANILSFLEDSLFLHIFYHPGSRDVYLELPRLRLGFFFKTGNDTIWSRQYQDMSIDRSQNVGTLFGLTSKLVLKSSDGSRRVLIPEGRVSYHRHSGHVSVSVKRGESRVHSYCVDEQLGRLVGSGSMQSMLLLCYLHSLTSYCLPDPLIRVTGTEQALAIITSAAVRSFDLLGRDNLDTLELIAQLAPKRLFYPPHLQDMQTVHWDPGLSFLSQHGQLYCEVRDIFSQAARSKPLHPHFVDPPSLDWTRFHLLERDLIRSSTFRVSGFGAENYTNKYDVCYWPRDHDQRSDRAQRAFVVARSVFNKEPILHNQSLIHLRGYLWKELSVQEPIPGPQTVLAQTETLYGGHLLGKTAQYLASQWCPAHLSLSRSDCESRYRLMMWLSTIAFAQKADMLLIETFTAFYCIRNIGRIVPPDHRVFNVKEGDRVRNLAASIKYRPVEVCPEARLPPLARESAADTRTRRRRVHQREQKVAKTSFTRMLEGQWPCEHPIRPSGNEVDVYIKVEAAMAIITAMWKVWWQNLQFHSYLNDIESELKVQSYRVLDTKLNDFQHCDIPGRNRKRHIRNQDVFDLPPPQIPDCFVDNLAWLVQSSREQEHPSARVECLLVALESRVSASHEQQYLSDLRDSIAHLNRDSQTHVLACSDLENIDGLLQYHRDVCRQQVQDLFGGLVQRSNQGFELAASVLHAPRTSQRFYLQQLSHSRWHSLSDDWRRYLVRYAKALRALQRAERLTRTNINSIDWISELINVGDQNWDPMTFPEWLLLEVESGLLMREVQASIAKHMLSPEAGRNSVMQLNMGEGKSTFIVPAVAATLANGQSFVRVFVARPQSKQMFQMLVSKLGGLLGRRIYHMPISRSLRLGVSEAESLWAMYAECMKNGGILLVQPEHVLSFKLMAIESILNDDDLLGQSLLKSLHFFDTESRDVIDESDENFSVKFELIYTMGLQQPVELSPDRWILIQHILGLVARFAPEIVVMKGTQSIEVDDRSGRFPRIRILQPEAGSHLRMLIAGHICKSGLVGFPITHQCAEMRQAIFRYITQPNLNPEEIAKIEDKDSAVWNSSSKGPLLLVRGLLAGGVLDLVLGSKRWRVNYGIDPLRLPPTKLAVPFRAKDCPSPRSEFSHPDVVIMLTSLSYYYGGLSEEDLFHNFQHLLRADQADVEYLIWTDSAPNLPERFRHLSSINLKDRFQCVEEIFPALRFSKGAIDYFLSHYVFQKYMKEFPFKISASGWDLGQAKSKPTTGFSGTIDSRHLLPLDVYHLDLEQQKHTSALVLKYILQPENSVQVLPLRNALSQEERQISNADILLQTVNAMHPAVRVILDVGAQILELNNQQVVEKWLGMWEDTQETEAAVFFNENDDISVIDRKGQVELLQVSPYAGRLDVCLVFLDEAHTRGTDLRLPTNYRAAVTLGPCLTKDRLVQACMRMRKLGKGQSLVFCIPDEIRNKILQLKEIVDRSLIEVSDVLSWCISETFVDHRRSMPLWAMQGHRFISQRKVWEAAHRNDCIVLSNEMAKQFLEEESHSLNHRYRPGTTEEKQFNKAVQDKNVARILQRCREFNISNTKSAALEEEQERELSPEIEEEQEVEKPARAQALKHSLHKDLISIVATGKIVEHSQALLPAFKTLLDTTAAECFDTSQFPGDLLVTADFSRTVRAIGGRYVSDSYLRPVQWILTCTNNSGGMILIIISPFEAQKLLPGVRKFKKVSLHIYLPRPNLQFRPLDSLDLFTEGGSFRLSTLPQQVSIQLNLFAGQLYLSTFEEYTAICDFLGLAWQPQEHGIEVSSDGFIIRSNPSSFATSPVKFLYVFMTKIRRNCDSIEKTHIGRILNGTLLEETDFVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXB4</accession>
    <name>A0A3D8SXB4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_02079</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW90914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SXB4"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW90914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="118" mass="13160" checksum="8DFEC0ACE79C2C7B" modified="2019-01-16" version="1">MSPVDVGSDVSRLQNAKVAHSPRDTLTLTRRITTNNDLRTIFEPNTAIHIYSQHLRLTRALGGLEEVDLHAKQLGTIWGEIIEYYHSPAVNDRYNQINYYTGPSPIVEVGSIGTSGVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXK1</accession>
    <name>A0A3D8SXK1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_02201</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SXK1"/>
    <dbReference type="OrthoDB" id="10265891at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF31">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G09850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW91036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="357" mass="37797" checksum="BE89401BD7A1EC1E" modified="2019-01-16" version="1">MASPQQLRTTVTDLLQINHPVLLAGMNVAAGPKLAAAVTNAGGLGVIGGVGYTPDMLREQIAELKSYLNDKNAPFGVDLLLPQVGGSARKTNYDYTKGKLDELTSIIIDSGAKLFVSAVGVPPKKVVDRLHAAGIIYMNMIGHPKHVKKCLDLGVDMICAQGGEGGGHTGDVPTTVLIPAVVDLCKGKTGGLGKQVQVVAAGGIYNGQTVAAALMLGASAVWVGTRFILTDEAGAPKAHQEAVRTAGHDDNVRTIIFTGRPLRVRTNSYIKNWEEERAPEIKELTGKGIIPVEHDFEKLGDDIDDETMDNARPFLMGKAAAVVNEKKSAKAVVDELVTDAVAWIHKGESLIQTKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZG6</accession>
    <name>A0A3D8SZG6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_02804</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZG6"/>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="71"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="25"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="49"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW91639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="597" mass="67556" checksum="677B251562B4D413" modified="2019-01-16" version="1">MAQERLPSRSASGLTSLSLRGADLGSAGAIVQLEPKTDSKPRKRRKNTKQVSNPSTQGCPISIRPDILLDRIRRVKCDETKPQCMRCTNTGRKCDGYPHAAALDQDKSHSPGNFPVPASTSAHETPAPVLEFPSADPILLRHSLLDFQGTQIEHRYLDFFHSQTAPSLAGHFDGYFWTTIVPQIGCSEASVRHAMIALGSFHESFSLEEMGMTDSGLQFALRQYNKAIRDLTFSKKLREENVAAVLTTCILFICLDLLRGNLKQAVDHITGGIRILNAHQMSISNYLNPKVPTSFEMDFIGIFSRLIVQGNLCGYPLPPLQLASTNTVSDLDIMQGPFITIDDARKSLGDIMMFAMPYIQTCMSLKFLPDKECLESSKATRERILNQLEVWRKRMDLFIVEKYPDGKHEDMGIYTLFSGYQNSAIWTKIVIYEEECAWDGEIECFREMVSLARSVTDNSSNKTRKGPYSLVGLPRRSPKRPLWRDAITFEMGILPHLYFTAVRCRDSKLRREAIKLLGLARPRREGFWDARILIKVAKRVVEIEEDGLSGEGLPVEEKRVHDTYILDECQNSSRMQKIVIITKREGEWNFKEEMIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZQ0</accession>
    <name>A0A3D8SZQ0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-dioxygenase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_01186</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZQ0"/>
    <dbReference type="OrthoDB" id="187894at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048244">
        <property type="term" value="F:phytanoyl-CoA dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001561">
        <property type="term" value="P:fatty acid alpha-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047128">
        <property type="entry name" value="PhyH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21308">
        <property type="entry name" value="PHYTANOYL-COA ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21308:SF8">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G09620)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW91792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="402" mass="44574" checksum="35A45642710E4D85" modified="2019-01-16" version="1">MPATTATETLYASITQAPNRVHSTNRPPSLAAIKTICSETASTKQYPHCEGIESNVPIYNLLKFDPTDPVTASALQEEWYNILHSGPGVFVLRNMYSNKALLEQVNGVFQKTIDHERSSSAKKGDHFAGNGKNDRIWNSFSKHGLQDPMSFFEYYFNSWLALVSDAWLGPGYCITAQVNIVRPGGEAQTVHRDYHLGFQTAEECARYPKSMHNASQFLTLQGAVAHSDMPDGTGSTRLLPFSQRFEEGFMAYRLPEFNEFFLSNYVSLPLSMGDGIFFNPALFHAAGNNQSTDFVRKANLLQISSAFGKTMESVDGLPLIERCWDALKQKYEAEGFSAEVKAFVSAVAAGYPFPTNLDVRSPAPGGLAPESEQQTVLKALQENWDKQEILGAIQQIREDSRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZS7</accession>
    <name>A0A3D8SZS7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_01143</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZS7"/>
    <dbReference type="OrthoDB" id="4158087at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="484" mass="54154" checksum="1FBA19221C0650B3" modified="2019-01-16" version="1">MDEQTPKFAFVAGGESGKPRREPVEQPVVQWLGPDDAPNPSARPLLLSFSVSTLHKEKNKRIVRRSTTKDRRRILTPQQLHAETAANNIIACPVPNPPLLRFADHLGPDSLELLFTVFPGTLRAFSLADFSLLSNLKSTQWQDWLFTDVAYVHAAITVSTVARDLLLKREPKLPSFHLRRAISQLNKNLFHKSVCLSDATIAVIISLSMASWISQDYASTSSHVAGLSEIVRLRGGLDSFHSNPQLQVGMTRIDFCVSLGSGKSPIFTTGPSTFPYESNSVQLSTCGQQSVPPDLQSIENLVDDRVAAIFQDLQGLARSMNAAASSQRVMLASDFHAGVMSIQYRLFELHSKLNDIISEWIRVAMLASLTTTFQVMGSRIKYQYLTDRLRELCCAVEVSTEELRPVMFWVLMVGTIALFDSGEPWLSKKWRLDVLPLVRGLQWEDAKRLLKRFIWIDACNEKAGTATFNKIKQDLGDGSRHDRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T035</accession>
    <name>A0A3D8T035_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_01185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T035"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF12">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="22"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="222"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW91791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="564" mass="63404" checksum="AE5A83CBCFAA547B" modified="2019-01-16" version="1">MRLIDTRTGELVSKTNPEPGSYAILSHTWGDEDEEVSIQNYGDPATASIKTGLAKIAGVIRIAQSLNLNYVWVDTCCIDKSSSAELSEAINSMFTWYQDSAICVVYLSDLPSHANFEDNFPRCRWLTRGWTLQELIAPKHVQFYTEAWELCGDRSSRRDILSRVTGIDTEILENSEGLGQIPIARRMSWASNRHTTRVEDQAYCLLGIFGINMPMIYGEGPKAFMRLQEEIAKDSGDLSLFAWATTDDAPPKQDQRYRGIFATSPKEFTIARGMKYRSAGILLEKEFSVTNRGLKIKTTLVEVPGLSMDLVLNLGVSDRDDWPRASSQGWMGIYLTKTSNGLVRSNPNELYTAGAHLRYLHKSASPAFYIRKTVSPSESVDLEKRFTNAIHVPQIQSFFRIQHAAPDHLWDPLRGMFLHQGMGINAYLRLIFHPQYGKYDGFQVIIACSTMAHKPVCTLWMEGVDQWHNVRHFLENRKEVSDYVAVDYLSGFVGGDTSVLSSSASTKFQDPATNNTVILTVNVKDCWIEGGTPAYSLEANVATIPCNSDKHTYDAHGYRSTLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T037</accession>
    <name>A0A3D8T037_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">eIF-2-alpha kinase activator GCN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_02533</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GCN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5148094at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904688">
        <property type="term" value="P:regulation of cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000090">
        <property type="entry name" value="eIF-2-alpha kinase activator GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022716">
        <property type="entry name" value="Gcn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056810">
        <property type="entry name" value="GNC1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057546">
        <property type="entry name" value="HEAT_GCN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056809">
        <property type="entry name" value="HEAT_GCN1_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF7">
        <property type="entry name" value="STALLED RIBOSOME SENSOR GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12074">
        <property type="entry name" value="Gcn1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24993">
        <property type="entry name" value="GNC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23271">
        <property type="entry name" value="HEAT_GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25801">
        <property type="entry name" value="HEAT_GCN1_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24916">
        <property type="entry name" value="HEAT_GCN1_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="TOG" evidence="6">
        <location>
            <begin position="1358"/>
            <end position="1594"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="1535"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="domain" description="TOG" evidence="6">
        <location>
            <begin position="1678"/>
            <end position="1892"/>
        </location>
    </feature>
    <feature type="repeat" description="HEAT" evidence="4">
        <location>
            <begin position="1995"/>
            <end position="2032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2646"/>
            <end position="2665"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00072275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW91368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="2687" mass="293268" checksum="7E78639E414C0DBD" modified="2019-01-16" version="1">MTEVEVNGTGGISLDFTATKAALSSASTSLRQAHLHTLEERLAKNEINHELFPPLLQHFFNTYSYYQDRPSRTAVQRCIRSIFSSRPPPDVLSGFIKAIHVEATKPGIAATNAFVLVEWCSILLQVISTVDEWEKWGLAILLTDAQVLELCLRATTRPNVSHSSLVVTWRALRSLLTARKQEIKELAPQKVIEDVVTKLTAKGAQPSWKNAIMLGALAGVCARKPGAKEILETKKNDVFTFYTREIIGSRTPVPSHIANGLHDFFVDFTSTEDIEKQVIPPLEKALLRAPEIVLNDLVTPLFKALPKAIDLSSILKNNLLKPLLSNIKSTNATIRLGALAAFKAAVLKCNNLELMTQVGSEVMAPLKTGKLASADHRALHADMLTVLPLSTSTVSALAAEIATVATKETNEAALSSETSALLHFVKWGVQNGSEVDKAVIDAFSKGLSDKKIPVRKLWSVRFGELLWAIEDLDIVKSKISKLAEASVVPLIQAWNETIANPTAAGQSGLVTIAYVFTAVSQSKLSLISSSKIDGELKKAQIFKHALAVEPKPSYILNQRVYGKLVADEDCLWFSRALSSLAEAVVTMDPNSEVALTWSQAVIFSVCSSGTKPSLRKQATEALTRMYMQNPVKISQIIVSGIWRWRHCIETSDKDSAAAAAKSDIQNLHIVVRAICPSSGGDEQNGKAVVDISIRKEQMVSLLVLSRPELVPRISWIDLCLRVGVDPGDLARDFADTMMDQIRMLTTYDEKKSLQSEIVRNATFNAAAELAFVAPDAMTPRIVQLIEHDLDPEKLSDIGPTEAAIFRTPEGTAFVDVLAKKTQTYVPNKNTKDYDTLKWEEELRSQLAEKKGQQKKLTPDEAAKVNAQLKKEAAIRLRIKGLQAELLRGIGIVRSLATGPPTEAHLWIGPAVKALVNTINAGAGLITGNAAADAYILCSNRTAARIGTLRQFIGVATLRAMEVPNLPEELCQEPLGPLITRVLYRLRFSGEQRPFDTVSLTYILPLVFLVLRNGGFGDTDDAEAQLVLALEFMSFHTDTCSDSLAPREEVLSVLIFSMQNYNQHYKMIKDCLADLCRCIAPNITNKEIAILARGAIVPQVSVRTSVLQSISAEIDLSELDFSEEMWLACHDDVDENIDLGREIWEESGFKITEKSPFTMLPYLESTDKELRRAAARSLAEAAKLQLSTLDDILSRLRSSYQELAKPRVQQLDEYGMPRKMDLSDPWQARHGIALAFKEMAPIFNERLLDEFLQWLIEQGPLGDQNPSVREEMVEAATAVIALHGKNKVENLMKTFEQTLEAPDKGSESADRVNEAVIIMYGALARHLQAGDPRVPKVVNRLLETLSTPSETVQYAVAECLPPLVRASSSKTSEYVQTVLDKLLNSKKYAARRGAAYGLAGIVHGKGISALRENRILMTLKGAVENKKDVNHREGGLLAFELFSTILGRIFEPYVIQIVPQLLSSFGDSSADVREACLAAAKACFASLSSYGVKQILPTLLDGLDDDQWRSKKGACDLLGAMAYLDPQQLAQSLPEIIPPLTGVLNDSHKEVRLAANRSLKRFGEVISNPEIKSLVNILLKALSDPTKYTDDALDSLIKVQFVHYLDAPSLALVVRILERGLGDRSATKRKSAQVIGSLAHLTERKDLISHLPILVAGLKVAVVDPVPTTRATASKALGSLIEKLGEDALPDLIPGLMQTLKSDTGAGDRLGSAQALSEVLAGLGTSRLEETLPTILQNVSSSKPSVREGFMSLFIFLPVCFGNSFANYLSKIIPPILSGLADDVESIRDTSLRAGRLLVKNFATKSIDLLLPELERGLADDNYRIRLSSVELVGDLLFNLTGISANTEAEDAEEGAQEAGASLLEVLGEEKRNKVLSSLYICRCDTSGLVRTAAVEVWKALVASPRTLKELVPTLTQLIIRRLGSSNLEQKVIAGNALGELIRKAGDGVLATLLPTLEEGLQTSTDTDAKQGICIALRELISSASVEALEDHEKTLIAVVRTALIDSDEDVREAAAEAFDSLQQIFGKRAVDQVLPHLLSLLRTEDEADNALSALLTLLTETTRSNIILPNLIPTLTTSPISSFNAKALASLSTVAGSSMTRRLPSILNSLMDNIITCKDDDLRADLDASFDTVILSIDEFDGLNTTMSVMLTLVKHDDHRRRAAADLHLAKFFSSSTIDYSRYNQDIIRALLNSFDDRDPEVVKAAWAALNEFTKHLKKEEMEALVYSTRQALQHVGVPGSNLPGFGLPKGINAILPIFLQGLMNGTAEQRTQSALAISDIVDRTSGDSLKPFVTQITGPLIRVVSERSVDVKAAILLTLNNLLEKIPTFLKPFLPQLQRTFAKSLADTSSEVLRTRAAKALGTLITLTPRIDPLIAELVTGSRTSDSGVRNAMLKALYEVVSKAGANMSEASRNAVLGLIDTDAEDNDIAMGITNAKLLGALIKNVIPEAATSLIKNRVVPNHPSHSSVLALNAVLLEAASSLTETAFADDLPQILCHGMSSKNNFISDNCVLATGKYLLTDTRSGDFEALKALFETLATLIQPGNSVDTRRLALVVIRTICRHHEDIVRPHLALLAPPIFASVRDPVIPVKLAAEAAFMALFSVVDEESKVFDKYISSQDMPANSKRSMQDYFKRVALRLGTQARERREAEGGQGGLGLSNDEVDDEREIWSIGKVDLGEKAFDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T089</accession>
    <name>A0A3D8T089_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RAD52 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_02583</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RAD52 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T089"/>
    <dbReference type="OrthoDB" id="206565at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045002">
        <property type="term" value="P:double-strand break repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.80:FF:000001">
        <property type="entry name" value="DNA repair protein RAD52 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.80">
        <property type="entry name" value="DNA repair protein Rad52/59/22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004585">
        <property type="entry name" value="DNA_recomb/repair_Rad52"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041247">
        <property type="entry name" value="Rad52_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007232">
        <property type="entry name" value="Rad52_Rad59_Rad22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042525">
        <property type="entry name" value="Rad52_Rad59_Rad22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00607">
        <property type="entry name" value="rad52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132">
        <property type="entry name" value="DNA REPAIR AND RECOMBINATION PROTEIN RAD52, RAD59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12132:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04098">
        <property type="entry name" value="Rad52_Rad22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="197"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="259"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="202"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="221"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="259"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="310"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="399"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="446"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00077224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW91418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="531" mass="56543" checksum="E084AE1E0601685D" modified="2019-01-16" version="1">MPAPGEQHQNTGNLAVMNPFEEVKPKVSEYTAQEIATLQSRLEKQLGPEYISARAGPGGQKVHYIAAEKCIQLANEVFGFNGWSSQIMNTQVDFVDESPQTGKVSLGLSVIVRVTLRDGTYHEDVGYGHIDNCKGKAPAFEKAKKEGTTDALKRALRNFGNVLGNCIYDKDYLGKVTKVKVQPTKFDVGRLHRHSTYAPVNRESELPKPLEDRPSNPSTEDALDDEFGDFDEADFSVPTDPDAHPDEVILPASVSARDFNNSRTAGSNTNAPSSAVTGTLANQSKPSVSRPQPMAAPARPPHPPGPILQAPQTPNSGFSRSNSGAGPGMQTRSQDTGVARVAIPGTGRVLNQPSRNIPPPAPESLAPNRLSSNDPESISLPPAGAGFFSARAAQLLPEGQNNDSVPANIPSNLPAFNPHAESPSIRKTPGIDHTSSKPLTRDLKHAPSSSQASAPPSRPNIINPSMDVTRRIGAPGSPSPMANRGQYKAPTLKRPMDQSNTVRAPLVDLPANEAIGSGDAGDVKRQRVNGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0Q5</accession>
    <name>A0A3D8T0Q5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Urea carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_02753</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0Q5"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.20:FF:000010">
        <property type="entry name" value="Propionyl-CoA carboxylase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001882">
        <property type="entry name" value="Biotin_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050856">
        <property type="entry name" value="Biotin_carboxylase_complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003778">
        <property type="entry name" value="CT_A_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003833">
        <property type="entry name" value="CT_C_D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866">
        <property type="entry name" value="CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18866:SF128">
        <property type="entry name" value="UREA AMIDOLYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02626">
        <property type="entry name" value="CT_A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02682">
        <property type="entry name" value="CT_C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00796">
        <property type="entry name" value="AHS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00797">
        <property type="entry name" value="AHS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160467">
        <property type="entry name" value="PH0987 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00188">
        <property type="entry name" value="BIOTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0092">Biotin</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="10">
        <location>
            <begin position="8"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="9">
        <location>
            <begin position="126"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="8">
        <location>
            <begin position="1163"/>
            <end position="1235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW91588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1244" mass="135649" checksum="6F20A10CCAD99027" modified="2019-01-16" version="1">MAAYTFSHVKKVLVANRGEIAVRCIKACAAAGIKSVSVYTESDSTSDHVSLADEAVLLSGQNVNGYLNVENLLQICKSHQVDAVIPGYGFLSENVDFAKEVQDAGMIFVGPSSESILEMGQKHRARALAVEADVPVVPGSELLTSEADAIAAATKLGYPIMLKATGGGGGMGLEVCNAEEDIKSAFTKVKGRGDSLFGNNGVFMEKYYPSSRHVEVQVFGNGEEVIHFGERECSIQRRHQKVIEECPSPYVHSHPEMRQRLTKCAVAYASKLKYKSAGTVEFLVDDISGDFFFLEMNTRLQVEHGITELCYNVDLVALMLRQADYEKSGAVGIPTADLRSFQKDGPNGAAIEVRVYAEVPYRNFAPSPGLLQAVDWPQGDGIRVDTWVRTGQRIAPYYDPLLAKVMVHAVDRATAMPKMLKTLSDCLLQGPATNLHYLSAVIASEGFQKGETLTNYLSTKFQYKPCAFDVLAAGAFSTVQDYPARATSGHGIPKGGPMDNISSRIANVLVGNSPGMETLEITISGPELLFTASAVFAVCGAPMPVTIDGIEKPMWSRLVIKAGQKLKIGAAKNGGCRNYLAIKGGFPDVPVYLGSKAATPSLKYGGTQGRQLQTSDYIALAEETEIWAAEATEYTLPASCIPNFDISEVYVLHGPHDDDTFMTAKDREMLYSTKWKIGHNSNRTGIRLIGPVPEWSRKDGGDGGAHPSNCFDYGYPLGGINWGGDSSVVFSMDSPNLGGLICSSTVISADLWRMGQLKPGEYVRLKPTTYDNSLQLTDRVEKYVSQMQELVEGKTTHVPVLDVALPEGETGAVLKKVEGDGGVRPEVKYRQGGDSYLIVEFGQQKADITITCRIRLLIQKIEALQIPGIVMNPSIIGVTIQFDSRVITQHELLHKVDELESAIEPTLDVTIPVRTVKLPVVLDHPSLTECLERYMATIRSTAGYLPDNVDYLRKANGFSTRREVFEILLQSRFLIVSVGFLVGNPILFPLNPMSHITGQKFNPTRIATPGGTVGIGGSLFSLYPVEQPGGYMMLARTLETWDTFGTKPGFSPTNPWLWEPFDMVTFYEVSVDEYNSIEADFIAGRYQWNVSEDIFNLHEIYNVLEAAKTDPKYVAFKEGQRKGVAEQLAIENKMYSEWTAGLAATAASEAERLKEIMLLNPNPINIDSPIDANVWKVEVNVGDVLKKDQVVVILEAMKMEINILVPEDAIGSTVQAIASKPGSTVAPGSLLVVAKGKEPDPKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0X9</accession>
    <name>A0A3D8T0X9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_01588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3552690at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1037"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1156"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="698"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="715"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="749"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="766"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="794"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="821"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="838"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="909"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="933"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="975"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1188"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1209"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1254"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1266"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1306"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1322"/>
            <end position="1334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW92194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1352" mass="149588" checksum="423F7D5C120C694E" modified="2019-01-16" version="1">MASPPEPDVDRTAETSSVSDGGIDQAPDAATLAEQDTIALCIERAFESMDVPHFYEEETDMDDTDDEETDSDEPNDETSEETDGDIDDEETDDEETDDEETDDEETDDEETDDEETDDEETDDERTVYDETIAELITEAINRASDASSMSEEDDLTLCIERALERMNLTDFSEEDAVANDEDVEEDVFSQFINMDGLSAQENLQATGMNLTDASEEEPVAYWEDVEENFLNSFSNIDDWSAQEDLQAAGLNLPLVSDKYQASMMAWAQHFEELSYQGAVYRTGIVLFVYDHYFDFRQFAMHYPGSKVLGVGQLHDWQWHINERGYPNIRNVMRTPLPFLNPDRDPALSQPMINDMINSRPASTYGYVFEICPDTFNELIMEYGMTHQWCKQYVQLPIGEKNYRSACYVFYDARHTCDRRGVDILLDQYEKALWSGGFELMRLLDVPESFQHEVLMSLQGNPKYQLPCQDANERIIYGFEKLSNLHEYLKEVESRSNYLDPAVRPRESYPRPEAAEQGQVYPETAQRSDSADVQDIDDFEFNQNLQPEQDGPSESVHMWNVTEEEEYHHSKSVQPLEPVNEKGKGKEASTLIQPPVPSISPFLSSSQIAPLLPSLWAYRQIKDGGEELYEINRDDLIWEETYACSERSSQQSSPRQADHSLILGAPKESRSIAEVQFHNRESNKSDLVSSISPPNTHKSTNKPSRKHRHKKEDIPSSSSSSTASKKSIPLKLSLRLPPPSSHPQGPTRGYFSSSRVLEDTSAATPESSDSSLSSGTSSQSEIPPPRLQGPKRGYFSSSKAPKQSSIITPSGFPRIILKLGTSSQSPKPSSSQQGPERGYSSSSTAPKQTSTAEPSSSSKQNPPRFGFPRSPLRDPSRGYISPPTVPKPTSAFVAHPSKLRFSTTMTGDNSPSGDSPEGGPSRSSELLGRDRSSPVGTARSNVPATPKKARRFSSGDGKSRSMTIEGARKRATDNRSSSSSSSSPSSTESSTPSPDHASSSGTSRHSEVQLMASVDDATLGKMVKELLTAPFIAGDADLGQRVRTLATVQSGMRDEPTPPSQDLSPDPPRIQFKDVTPSPEAVAAFWQNAEDAIAKQDQVFRETGKKGRIPWTSKHGVIESGQGFVPSQDIVDLMKKLHGKLDDKSKAKAQECLERVQQQMADYEENKNSSSSSAAGVPQPVVQHHERQGSSSSTVSMKPTAASDLQSTAEHNRPGPRDLQEAQDNESRYLDAFINELSNNMDEESRAQFAGIVKRTQESMKNYEDPQASSSSSTTMEPAAASNNTSAGQLTRAVEHGPVVTPSPQNSRRQSSTPSLSSSPTSGTHRASSRFNLQPDTPCKPRRPRKQSNGGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T174</accession>
    <name>A0A3D8T174_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">M protein, serotype 2.1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_01678</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T174"/>
    <dbReference type="OrthoDB" id="2121319at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38120">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38120:SF1">
        <property type="entry name" value="M PROTEIN, SEROTYPE 2.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="409"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="409"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="454"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW92284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="641" mass="70129" checksum="FDA1EBE309C7CF3F" modified="2019-01-16" version="1">MSTIAKKPPPATTMSGRRPSTDPNSSSSPSRGPSRSPTPSSPSVPNGVARTRSVRGGTPVSARAAALQRTGTNLSSATAASDVDDESRAETITALDDLKERLHKAETTSEQLQKQNQVLQSRFEEANEEQGKLEEKLHESEERIEALENEKRDALRQKREMESIYEAERVSMTKEREEMTNREEEMQTIIQRLKDSLNQRNNVEEEHRLSRHSNNASPNLENQFAPPSALSRSDSRNNSKLVLQKDRLIESLRLELAEAQIKLVESENQGGGRLHEVEKLLLEARMTNARLMEDNESFQLLLSEKTLNLEDFAKDHFGFHSKSTNEDALSALEGRAPTSLADELSEVAEDGPEGVTGSEAEPDNYKRLEAELKSAKDSNKALTLYINKIIERLLEHSDFEAILDQSSDFKPKSRNVSNVEKELPPPPPPKEQASGASILQRAKSVAMGGRRQRPQSVMPTSYSALSDPDTAPSIPFGLGRSASHRTGRPMSEQYTSGAASVVNQMYRGQPPQNSPPLQGPQTPRHSQSFFAPPSISGNPNAAARAPSGGQAGTAGNFPGMKSETSSISGDSGVTTPPSNSPPRAEKQTTFAGNKPRPLRLVQDNADRKVSDESNKRASWMGWATGAFGKKDEPIATEAIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1H3</accession>
    <name>A0A3D8T1H3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_01743</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1H3"/>
    <dbReference type="OrthoDB" id="2991872at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW92349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="531" mass="59690" checksum="7A2C027D7A1EB280" modified="2019-01-16" version="1">MPTKSRCDEQIPACKRCVKRNEICTGYRDDSTLLFRDENAKAAFAAHAPVRRRASSQSARSRVRNDSSASISGKSSTSAPSDDASSPCARPKPLSSPQDDEAISQFFSEYVVYPCTQNSTPGFLEQLPCLFEEVQHSGRIALRMAVEAVSFANIATKGPRNDDLVRKAQQCYGSSLEALANTLEKKEEQVSDYTLMTVVVLDLFEVILHSKLPVSLGTYYFQSIFTPSPLSRTTHSEGLKLLLRLRGPSQIYSERGWSLFRLAHHRIQRTQLSFKHPAMPEQSAWLNSLNDGLPGIRGEKENLEISKICQRARELQKRLRKSSTGQDSEVLQLVKEMHALDQTASTWRVGSQWAFRILTNPYQPSSTTFPEHIHIYPDLWIAYEWNYHRTARIIMHEHLLKCLASLSCHTQTPIQSSYQPSTTTEEEVSALSMFSRHIINTLIEEIFSTVPQLLGDVNSLEDVPIQRDLEKTGEEAEGRGTKAIGAYFLLWSIKVVKSTNSATEMQRERAGLVLERLRKVGGMFDLDSSGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1N1</accession>
    <name>A0A3D8T1N1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tetraspanin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_01838</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1N1"/>
    <dbReference type="OrthoDB" id="2279611at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW92444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="224" mass="24394" checksum="908F0D18B2004671" modified="2019-01-16" version="1">MRNNILLTYVVMDLLFVATGALLLVFSLSMESRVRATPTLANITTNLLLDVCPLKAGVANAVFIFVSFVISLPGILSSTTRGWLKFHGYMVVISGLFTMVIGLVIWFETLKTRNNLFNIWNLQPATSQSLIQESLVCCGYFNSTAPPFVVDSVCPTAAVAATQIGCVTPFTSLANAFLDTIFTAAFGIVGVDVAVILAIAMLLKDRKEKERYRHIDEKNGANGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T204</accession>
    <name>A0A3D8T204_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rad21/Rec8-like protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_01954</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T204"/>
    <dbReference type="OrthoDB" id="5427633at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030892">
        <property type="term" value="C:mitotic cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21789">
        <property type="entry name" value="Rad21_Rec8_M_SpRec8p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF70">
        <property type="entry name" value="RAD21_REC8 N TERMINAL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G02900)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="262"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="401"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="274"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="415"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="476"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW92560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="697" mass="75599" checksum="3BD1EDC8D2F8CA0D" modified="2019-01-16" version="1">MEPEAPLALRLQGNLLYGVSRVYSQQVGYVLADTQTAQNTIRALMKISSSNALDPGAGKTRPNQLILMDDPAFVPDMELLPFDFDLSQLERDIVAAGSSQQSLMSPGGRYHSSASVSQRSATLPGISLPSSSSFNAGFHLLQPEDPFGEPSTQKNLGITGRPFPNEEQNMFEELNLDFVIGEDGIMHDVTEEELQARRVSDPLLQGRKESDSAASAHVRREHQDVIAGLNNPLIDADGDFVMMQYDDDQILPYAAPFPVMSGANPSAPPRGHGPSATLSPLTPSSESGAEALQRARKPRRAKLMPVDQQLEYRNADLRSWQNCYLDNMAKAIKDRELHQTRKSAKKTAYQYVCGGGLGGVGNGVGFARLQGPLAGMFSGDALLEGLTGKVIGLKVSVERGTKRSLDEVTSGTTDSEPRRVRARQEEELGRGINMSFNDADGGMLGGNEDSSSIEIGRDAPSALDDHPPSSAMPWNMSASLHSHQRGQSSSIAGRGSQVASSLGAGARRSIIHSSPLIGRGSNIPGELEKFSLLQDESLPVQFGRSFEADSTNQSSDALLRKYNPSQAQGSQEQEFELFGTAAGVDTQTAASSQWMRSALDNESNNFFEYVRNSILEKSDHLAIDEDEDELQAAGEEAYYVSFEELFHPIQNSKVVAAQAFYHVLNLATRRRIWVKQLETAEGELEGEIRIGVVGVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7E4</accession>
    <name>A0A3D8T7E4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_00240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7E4"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF87">
        <property type="entry name" value="COL-21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="99"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="55"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="132"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="663"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="664"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="707"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="732"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW94477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="833" mass="92463" checksum="97D4B7D40DCEA90E" modified="2019-01-16" version="1">MPSGCPKSPNRRLASPEELCAFIHFADAFANVASLESLDNVNSKVQWSERSEHKFVKQPVRETPPSIPKMSSEPSAADARHPTMEVVKPTRKRKRIVISCTECHRRKQKCDRASPCANCVARGKESSCHYENEAARKQQEDEDASSTAKNGNQNPANAIKTVSASAAQVATLGYAKDNGNNTLGLFKKIEDYGGDSNFLSATVSEAAHISGLREKYKSLIRQLPSKPHIEKLVETFFRDVNPTYFALDESTFKELWSEWSNLSFSTLNKGPLELSPDLRFFPGLLFQVIAQAMQFQPPDYDPSLDSLKYAAAMSLDDLACDYSESGVSILTLLGKRHTTLVTVQAGFLRTSFLKNCGLVPESWHSLSITIRDAQEIGLHKEIVDHQPRDPGQALENLWTIQLRRRMWLLLSVWDVHMALVLGRPTTIDLRDGWATFPIDAPVPKNRREVAPMPRSDSDPPTPLTALLWNAEITAPLRDILALEKEGPHPKDPSKIEKMHNQILMIGDHCPAFFRSENPDTTWDNYPDCYWLPRSRPGFANGIAFTIMALHRPYIFTNSSSRAAALNAALDILRAQQAYFGYLNAKHYKMFNIVLNTFDAIVVLAAIHIIHPWENREHIDDSLQHFDWAMERFQTISQRNVIAKGALGVLKAIHVRLMKALGLPKTNSPGPTKIGSNKSGPPRVRTPLPTPPIKSDIPSPVLSHSIYQQSQPISSTRSSISTTTNSAPNNVQASSTASSSYSPPDDSWNTTIPPTNFDVTSLAPLQPMHDLLFNDLTGAGFESQLDALGPGLEIYNQGLGIPAGGLSTVPNSSWQFEGDFGQDSFWGFMNNYNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7L6</accession>
    <name>A0A3D8T7L6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Translation machinery-associated protein 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_00310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7L6"/>
    <dbReference type="OrthoDB" id="548474at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038966">
        <property type="entry name" value="TMA17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40422:SF1">
        <property type="entry name" value="TRANSLATION MACHINERY-ASSOCIATED PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW94547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="20910" checksum="3529C5AB02628E7C" modified="2019-01-16" version="1">MSQEALPISPARFAEAIKDLPISTLHLKAAELRNSIAHLDYSNEQLLPFTEGTEPDQDCVDAIRENEVVIQRMQERIELLKKEVEDRGASWTEFQSSEELAAAAKVNGVPDVEGVNGIAEAENGQSSDAWRDGTFTTGRIVNGEVVMDGESTEPRTDNSMGGRLDDEALRRAVEDRLREDEEEEGGMHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7Y2</accession>
    <name>A0A3D8T7Y2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LDB19 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_00446</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7Y2"/>
    <dbReference type="OrthoDB" id="3832628at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070086">
        <property type="term" value="P:ubiquitin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050357">
        <property type="entry name" value="Arrestin_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024391">
        <property type="entry name" value="LDB19_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188">
        <property type="entry name" value="ARRESTIN DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11188:SF76">
        <property type="entry name" value="PROTEIN LDB19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13002">
        <property type="entry name" value="LDB19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LDB19 N-terminal" evidence="2">
        <location>
            <begin position="131"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="486"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW94683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="499" mass="55020" checksum="2157026177349E46" modified="2019-01-16" version="1">MPHRVATFFRSHTNNFDIPAELKKASRRSSSSKRPAVTERTPSSSASSIHSDYSSSSSNNGKMLDKRMSLTGLHAAKNSAAIKPHHPSLDVKIESPPLVFYGTTTNSSGALFSGQMMLDIPDDMLVLDNFKMKLVVETTRKKPFHAHCAECAQQVKELHRWDFHQGQATLKKGQHSYPFSYLFEGHLPASMNSSLVKIDYVLKATITPKSGEPIKLSKSLTVKRAVPPAETPKKSIRIFPPTNLTANCELPTVIHPIGEFNLTMRMDGVVKRNEDSKSQTQWRLKRMTWRLDEIQKEVSPACPKHLAKLGLAATGEDDQKKGTAHENVRTLNTDELKSGWKADYSAIDGGSIEMEFPFSIKPDARPICDTKSADGTEVTHQLVVEMIVAEEFAPISKPTQITPTGAARVLRMHFSVVVTERSGLGISWDEEQPPLYENVPDSPPTYGMVVDFETNELPDYEDLAPLDGAAPSTLAQPPPAHLPVERPSSSRSGPHGPSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7Z7</accession>
    <name>A0A3D8T7Z7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_00324</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7Z7"/>
    <dbReference type="OrthoDB" id="690068at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46266">
        <property type="entry name" value="TRANSCRIPTION FACTOR TT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46266:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR TT8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BHLH" evidence="2">
        <location>
            <begin position="146"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW94561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="368" mass="39555" checksum="5E5579F059FC049C" modified="2019-01-16" version="1">MPPGRAPPTPASSTEIKGLDGSQSIQMSFELPPPAVTEPGSTSASKSSSASSYQPSTPRSPAPTIPASETVKIRRRSSVAQPPAKDAFALPPPPTRSRKIIQMKPRGHSEQNVEAAAVEPSPAEGKSTPGKKKQPSATSVAGRKIARKTAHSLIERRRRSKMNEEFGVLKDMIPACSGDMHKLQILQATIDYVRYLEDCVGKLKVENQRNNPNTVLAEFQLPSPMKRDSHDSSKKYSGPENNEDDVEMEDSEAASPTNSTPVPSKHPSISPAIMPQDHRGRQDSYSSTSYGYTTSANTSPHFGASSYTYAHSNASVGSTLTSPALQPQRDRDLDHEATAALLMLNSDRRGAHGSISGRSMSVKDLLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T962</accession>
    <name>A0A3D8T962_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Urea transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_00863</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T962"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11476">
        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF2">
        <property type="entry name" value="SOLUTE SYMPORTER FAMILY TRANSPORTER (AFU_ORTHOLOGUE AFUA_6G03200)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="300"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="457"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="497"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="598"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="630"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW95100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="680" mass="72665" checksum="7959F72E16C1F450" modified="2019-01-16" version="1">MTTKVADLQVLSPSDGYGIVVGLGVAFTLIMIVLSLIQNRYGAHNTFKSTEEFNAASRSVKPGMIAAGIVSSWTHASTLLTSCTLAYSYGVGGGLWYGAVGTFQTLFFAVAAFKIKEKSNNAHTFPEIVLQKHGNIAHMVYTFFGLVTNLINGSALMAGGCAVFSALTGMNIWAAYWILPAIVTSYIVVGGLRATFICDYLHTIFLYVCIFSFMFKAYSTDPTLGSPAELWRLLKAQEATLPADSYNGSYMTVNSRDGLVTAATIFLGGFSGVWTDQAYWQRAIASQPATAVKGYVLGSLAWYAIPFAMSTTLGLTAAALTGTSLIPVKLSSEQVSAGLVGPAAAIALLGKAGAGLMVVLVFMAATSSTSAESIAASSLITFDIYKAYINPKATTRALFWVSVLGLVLYGIFLAAISCIFHSVGISLNWLVKILGCLLGGGTIPMVMVVLWDRTSTFAVIVSPVIGLASGLASWTVATKMRSGVINITTTSNAWSSLTGDCVSLGMGAVSVILFTFLVPNKKKLVVVEARSSEAAPDKFTVGAKDTELDAEGLGEAEKDGSNVVEENAAAQDLRPIGGEEYVPVEALTKEEAKSQQKLALVSLVVGALIFMILIPFTLYGSKYNFSVKFFTGFVAVVFIWIWVSCAICVFMPLWESRKDMWYIVKAMYRDATRSKVHHTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9N4</accession>
    <name>A0A3D8T9N4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GB1/RHD3-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="primary">SEY1</name>
        <name evidence="12" type="ORF">BP5796_00997</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <text evidence="8">Enriched in the cortical ER. Concentrated in punctae along the ER tubules.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9N4"/>
    <dbReference type="OrthoDB" id="1597724at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016320">
        <property type="term" value="P:endoplasmic reticulum membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01851">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000727">
        <property type="entry name" value="Protein SEY1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03109">
        <property type="entry name" value="Sey1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030386">
        <property type="entry name" value="G_GB1_RHD3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008803">
        <property type="entry name" value="RHD3/Sey1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046758">
        <property type="entry name" value="Sey1/RHD3-like_3HB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45923">
        <property type="entry name" value="PROTEIN SEY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45923:SF2">
        <property type="entry name" value="PROTEIN SEY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05879">
        <property type="entry name" value="RHD3_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20428">
        <property type="entry name" value="Sey1_3HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="1"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="8">
        <location>
            <begin position="799"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="802"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="8">
        <location>
            <begin position="823"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="domain" description="GB1/RHD3-type G" evidence="11">
        <location>
            <begin position="79"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="852"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="89"/>
            <end position="96"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW95234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="894" mass="100039" checksum="8A9A6F0739DC5ED6" modified="2019-01-16" version="1">MSSSTNGNGSSLHSPRRPSAASRFPTAPSVMTMNGHFAGLGEKPTIEQYEHGIQVIDEDKEFNPNLSTYLQVTKVAPAGFDYHLISVFGSQSTGKSTLLNHLFGTEFGVMSESERRQTTKGIWMSKNKKEAAEGSGAEKMANNILVMDVEGTDGRERGEDQDFERKSALFALATSEVLIVNIWEHQVGLYQGANMGLLKTVFEVNLQLFLKDKQSNPRSLLFFVIRDHLGTTPLANLRNTLIQDLSKIWSTLSKPKGLESSRIEDYFDFAFAALPHKILQPDKFLIEVGKLGTRFRAGHRTSKPGLPLDEEFTGGVFLPEYHRRIPADGVSKYAEGVWDQIVNNKDLDLPTQQELLAQFRCDEISREVLVAFDEAILPLEEKQAEGVRLGKPAVLADLGVTGKATRSKTIKAFETEASRYHKGVYTRKKVELEGKIDTRMKALYLGQLSAAHKAGVTDFSESVSGAVKNGQKKGGSYDFADIVEREKAVALKKFKKEAMGLAIEGVPWTNFKQQYGLYEKDLDEVSGRLRKEEMRRLATRVERWVRSRLGESVGLEFNKLGSGRGGSGAPEDGVKPATEKDLWDRIWKLFVTTVKEAETRFVERAKSFDASEEEIEVGLWRLRRKSWGVLKARIDEEVMEGNILLKLRENFEDKFRYDDDGVPRIWRPTDDIEGMYTKAKDSTLTLIPLLSRFRLAETYAPPELPEWIGLAPQSVDSKDEEDLIPIGGVDEEEGKSLEEEMTVLSEAKRQDLVVRFKKTADGVYVEAKRSAIGGVAQVPLYFYGLLLALGWNEIVAVLRNPVYFIFLILCGAAAYVTYTLNLWGPMIRMANAASAQAVEIGKEKLREFLESSDTGRQAMAMSSRDRDSDSISLNTLDSRGKRKPAVEDDDDDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9Y6</accession>
    <name>A0A3D8T9Y6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_00591</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9Y6"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW94828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="153" mass="16232" checksum="58025B2655C11908" modified="2019-01-16" version="1">MARMAVTLNNSTLASYTLSAPSTPPHPPTAARPNPNTTPGAGAVQSHCRGRRQGKEHAACWLGASSMGDSTVLSRRMHARCKRRTASDVSGPKQVRSASPALSMSDQDAMDRMSTPVSDEARCSWVDPGRRCSHFPLTPLESTGAGLVMGRVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8TAY4</accession>
    <name>A0A3D8TAY4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_00791</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8TAY4"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000426">
        <property type="entry name" value="Aldehyde reductase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF562">
        <property type="entry name" value="ALDEHYDE REDUCTASE II (AFU_ORTHOLOGUE AFUA_1G11360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="11"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW95028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="337" mass="36771" checksum="B952B55073F948FE" modified="2019-01-16" version="1">MAPAIPKGTLVLVTGVNGYIASHVADQILEAGYKVRGTSRTLEKGNAVKAALEKKHGAGKVEIVVVEDMEKEGAFDEAVKGVSGVAHVASNMSFDCDPHKVIPGVIAGVNNVLTSAAQEPGVQRFVYTSSSTAATRPKPNQKFTITKDSWNTEDIETAWKPAPYDRSRAMAVYGASKTQGEQELWKFVAEKKPSFVANAVLPNGNFGPLTFPTQSGSTATWIFSVYDGDFDPVRHVAPQYFVDVRDTARLHVAGLIDPNVQNERIFAFTEPFNFSDVIKIIKEIEPDHKLPEDALSNDRDLSEVAEIPRAIELLKEFGRDGFIPLKQSIIDTLASRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q8Y1</accession>
    <name>A0A3D8Q8Y1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 13">Fumarylacetoacetase</fullName>
            <ecNumber evidence="3 13">3.7.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Fumarylacetoacetate hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BP5796_12222</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>4-fumarylacetoacetate + H2O = acetoacetate + fumarate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10244"/>
            <dbReference type="ChEBI" id="CHEBI:13705"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18034"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="EC" id="3.7.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="13">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 13">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.7.1.2" evidence="3 13"/>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q8Y1"/>
    <dbReference type="OrthoDB" id="9971669at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00341"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004334">
        <property type="term" value="F:fumarylacetoacetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902000">
        <property type="term" value="P:homogentisate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.230">
        <property type="entry name" value="Fumarylacetoacetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005959">
        <property type="entry name" value="Fumarylacetoacetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015377">
        <property type="entry name" value="Fumarylacetoacetase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036462">
        <property type="entry name" value="Fumarylacetoacetase_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43069:SF2">
        <property type="entry name" value="FUMARYLACETOACETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09298">
        <property type="entry name" value="FAA_hydrolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63433">
        <property type="entry name" value="Fumarylacetoacetate hydrolase, FAH, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12 13" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 12 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Fumarylacetoacetase N-terminal" evidence="16">
        <location>
            <begin position="29"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="15">
        <location>
            <begin position="134"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="143"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="263"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR605959-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU366008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF09298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDW58292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="443" mass="48782" checksum="D97ACF72CF7BE5A0" modified="2019-01-16" version="1">MIIDKIHNGESSGQQGPSSSGKGSPFTIENIPYGIISTRSNPMRRCATAFEDNAVDLEVLEKGGLFQNVPGLEPGTFSQTTLNAFAALPSSSRLQVRETLIAFLSDNSLHGRFPDAFISLENIKNHYPMQTFNFSDFYCSLEHTRNCTEVFGVKEISPNWFALPSVYNGRTSSLVVSGTPITRPYGVIRTSESQVFAPTAQLDFELEMGVFISNPVPRGKRLSIAESSTHIFGFVLLNDWSSRDIQAFEMPPLGPFHSKGSGTSISPWIVTLEAMEAAHCPRATLQLPKPLGHLEWQGSDDKATWDVKVEVKVIRKSHSFYAGKSDTHVLGQSNLRELHWTPRQMITHLASAGEGLTTGDIFGTGTISSDRVDEKGEKIGLGCIIERKLERNTLAHLKDITSTYLMDGDEVVMEGWCCSKKTGNWFGFGQCKGVVLPAIKDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q947</accession>
    <name>A0A3D8Q947_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_12276</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3557006at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF15">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="212"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="938"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1504"/>
            <end position="1536"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1709"/>
            <end position="1732"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="1789"/>
            <end position="1821"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW58346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1832" mass="204731" checksum="12CF60F698D43971" modified="2019-01-16" version="1">MAEALGIAGSVAGLVQLSIAVYQGITKFCREAKDASFSVSQVATQTRNLAGVLQNLSLLSTSLELEGDNSSTSFQATYIDACFTTLRKVESRLQEAQDDFKSGKKSRIIVRSLKWPFSTDETKSLLGELGEHRNNLELALSADTARRLRECLSDTNSLKHSIDKLQVKIDRKIEIDTRVQLTKKRRKIVDFFLKVNPEPSFKTSQGLRMAETGKWLTERDAAFRNWMDVPGSKLWLSGIPGAGKTILAGAVIDETLQKQSTSTGIGYFFCDYKVPESQKTVNVLSALAVQLAKQATSAFKLLEAYYERLNPEHGLARNPEADELVKLVEKILSLYVHVYLVIDGLDECGEHVVEVVQSLKSLTTQPQTSIALFSRKEDDIRDELAAEYEPIEIAAHTEDLELYVLAEMEKRKSLKNLGLKHPDFHKHIRQTLVEGANGMFRWVACQLDHLSDLPNNTMRRNALTELPPTLFETYDRILDRVLQCPKSVQNVTRKALHWVGLGYPNLNVPALCEAVSIPDDIDILHEDDQVEIHEITRRCSSLIRLSHDSERFEYAHFTVKEYLQSLVMEPKRGFFRFEEDKAVQSLLITSLRFLTFSIFDQKPSPSPTEIKKMERRNEEHPFYSFAGSYVFGIGRHPKGVIFTNSFALILENEKVMKYARDLFHPRKSNTFLSWVLNFVLQSNQSRKEGDSMFADAIGIVLDRQFSTLHVAAMLALPTLCEYLLKSGEDVNVSCRLGSPLISLLIGIDLLFNIIYMNEYIPHIHCRRIYGGGEQEENVLTILLSAGADTSLKWHDTSILRLALGHYFQNHERPWILPLLSPTTVVEDDALEQLKIILGEAILKTECGATEIANAILAKHSESNSSRQWSRLQSIVRRCAMDQKVDLNKDFEVFAASTISDEEFPIVVKIAAEQNLIEEMMALVKDRRFSNSDLRFDPGGVTPLHVAARCGSATVVGILLEIEVDRSIDGLHSQHVLHDRNCEATTFPNRSQSNDNIRDDADNTVWHAAAEGGSVDVLEVLLENTDDLAIPLAVTSQQGRTPLACAIHEGNLDASLLLLQHCDVNSGHFQSDYPLLNEAVSLGSEKLFRALHGQLKNCNANSNASDESRPLHNIRPSCPPDFVDYLVSIFDIADTTHDGESSFELMLLGLKFESENPYKWPERHQLEHNIVALLPDSHELTSARRVKHAWEIFCESVLSKLTVEYDPEDTEKCDPIVSTVHILIDRGVLASYETKCHQSGYRPLFRGLLRQSQLGSEWRYKWITKIVDITLRKIRFTEDIKKDAVCTDLLARAITKHNVSLVEMLLDYGVDVHQANKDRSPIEQACFSSTLQIFRRVVDHSDHSLLDRPGHSGAFLLQLILKGPTRNKTDRVKELVKRGAKLDIVANDRFATPTVVMAAKLGYFDTLHYMLAQGADSLLRSNAGWSILHEVAWRGNTQILEDLRRLQPPLAFWSQSCNIIIDTPSGPIGMDSTATHISAVQGHVGFLKRLISLAIVNNVNNATRCNTTPLHQASWRGHLKMVKFLISNGANVNSQRSNGWLPLDCALDGSHFEVAKVLLDSGSHKPAYLSLSETDLRKLFPEGTDLTVTGSSITRHLGAIKSPAICLESAILSGNHGLCQRIIQDGCSVDVKMPNCQPCSSLVRAITADKPKIVDLLLSKGAKAENISCSSFHPVFGTIAALATHFLSSTDSLERVLSRALDSHISWYGSGLSPLHIAVLDGKIERLRLLLSHIRNNSETYRQVIGENLTIYPIDDGWLSRSVMSLLINELSQSFSAQAGVPWDLKGYFVSATPMHFAIIRRDLAAVKLLLAYEAEVDAIDLDGRTPLILAAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QA86</accession>
    <name>A0A3D8QA86_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_12304</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QA86"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF164">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW58374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="42380" checksum="EDD02F9C44943390" modified="2019-01-16" version="1">MAEIYTSGGGYTKTDLYSLFKQEGHTNLFTALDKKDHNEKKRRFTDLYSNSNILGSRVLDFIRDRAETFTSAYSEIASADIYLYLHCYTLDCVTAALFHPYRTQSIKGGSDKEMIEYFYNMFSRDVSNGGPLIHDYAWTSMRKGNHLDFTLAARLLEYPKIGLSNMVVECLDHIGAGIDTTGDTLCFLMWELSQPYNMKRMGRLSKELRTIKADGRLENLLYLSAVIQEALRLWAPGTLPLPCYIPNGGRVIDGYFLEAKVIVSCQSYTLHRFDSTVFENPDIFLPERWLEEECSTERQRLFFAFGSGARTCIGKYLALAEMRALLYSVYSQFRTRPADDMHASMKLSDQFITSRPEGMCCQLTFERLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QBI4</accession>
    <name>A0A3D8QBI4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fungal STAND N-terminal Goodbye domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_12063</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="448455at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031350">
        <property type="entry name" value="Goodbye_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF17">
        <property type="entry name" value="FUNGAL STAND N-TERMINAL GOODBYE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17109">
        <property type="entry name" value="Goodbye"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Fungal STAND N-terminal Goodbye" evidence="3">
        <location>
            <begin position="23"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="321"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1293"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1297"/>
            <end position="1312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW59139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1447" mass="163877" checksum="A3F678A2C7CA8822" modified="2019-01-16" version="1">MADDVKQMKVELERDQRDVSDLWNDALKKYRGIVQVDLDKLPVPRFTSTEEMIAYGSDQMEDFHRYRHNQKKVDKLRGLFRDSMWYIQKGAEQLAAAATPAFPPAAAISTAFSYMLNACKQVSADYDVVMNFFEDMNSFLQRITILESRLPSYPAYRNCLMDVFTSLLEMCAFATRYIREGRFKKWITNLIKGEDSDLGGARKKMDTSIDRLQSATEYAILGNTEEIQKMNTELRENQEAQTKMIETLLEKQDQMLTADAYFASYSKLLKLIEVQKDGDASRFKAKPAKGKVASANRVKNIFAVTNPMVEHRNIKYSFLNGTCTWLTGEANWNSWNAQKSGLLTISGPPGSGKSCLAAYAYDQLTASAEADANIVVASFYFREANKDFSSFVNAIYWIIIQIAEQDKALCEKILAETMREDDDLDLSDWHVVWTAILAPLFEEKSDSRLQLVLDGVDELDAQQRKLLIQFLNEIKEKHLNIAVLCTTRPNDMQELDGLGGCSMIVDKDKMMPDMQNLMWNRLDHFDRLHKFSRLAKQKIAWKVEEKADSLLYVEHILRRYDTIGREGAVLKDMDRVFPENLEGLYDLMLSDCLRRTPPEQRETLRIIFVWLAYSLRPLTLELLTSLQTFTSQGNSYDIEEELQGRLSRILQLVESTKASDEETNPKVSQLLRDTEAIDGPAKEQDDSSLPVQFQERSLRGFFRPSKKVESGLRTSYTPAHMSIFVTCSQILCSGATPNSESLQEYAAACWHSHFYSISGSELSDTDNISVLEALAAIMTNENNVSKTFEEIGFDYTNLLAVWEEGKFEKRVVDWAASAVKRFQPRLSSNASAWVQSVAEDSQNAWVPLAKAHIKNWYQATDITGSMRSFRYAQSAILKTNLKHLVDKGKKNKTGEDGLEESYSKEEITAVKDAFDDIEADAQAHWAISVAFEYCGHHVEALAEAEAALSMHDDQITWFRTLDLKAGIQLNLDNAEDAYKSISDALASNIHGIISSAAIREALVTRAKVEFKLGKFEEAAKSYEEARLACPGEILPGDILQAAAKVFEANDDYVGLISMLKNWTSFDRITWLTWQYDDNDTMQYTFREAAGKTGEHDFMVKTYEEVIQHLDQFNAGAPLRSELVLAHKEVRRDHEAAKHVLNDILDSNSTGDLYAFTKADPSDVLYNTICDMSDIIYEQFRSTSDPKLKGTLLDEVKNLTQRNLAQEIASLKSELTHHTVVIATILQKMGPILEFQDTLDGAFNACYEALSDSVGWNDSQNLVILATILARMTGLEKEAQIAVSALFSRLDPTLSDSADTEDDGSDDGSDDGSETSKLPTDEGDLTEDVEVACEGECIPPRKFHSWSGRSIYQCIVCTRCPLCEECYQKRQAYNHGEKLTNWRTYCGENHRYVRGPVKGWKGITDGVMTIEGEEPVSFKDWMTELKDVKWKKVWVDFWKNGTKDPDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QBL6</accession>
    <name>A0A3D8QBL6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_12160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QBL6"/>
    <dbReference type="OrthoDB" id="5419179at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11578">
        <property type="entry name" value="DUF3237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW59236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="153" mass="15792" checksum="4E7AEAD5D4F7503B" modified="2019-01-16" version="1">MAASTSASTVAIPTPSYLFSATVNLGKNLDPIPLLEGGIRIVEPITGGTISGPAFNATIEGGLAAPIIIRDDTGNGTKAQMAFIYAYGHASDGSPFYIDESGVGTGSSQTTRLIIQVGGQYQDLQTKYVLGQPSVNADRTVALVECFSVPLPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QBU5</accession>
    <name>A0A3D8QBU5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12125</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QBU5"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051531">
        <property type="entry name" value="N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792">
        <property type="entry name" value="GNAT FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00765)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792:SF1">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="105"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW59201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="264" mass="30080" checksum="1ED3421A4121B505" modified="2019-01-16" version="1">MWKITSAILQKLSTHIYAMEEPQVPFRPFLLLTARLILIPTPIAIAIPSYRALYASLHADPVFCGMGFGPSFGTRAWSDDETREVIHTRDIMRCWEPRGLGDFAVGIRPKGLDTDVGQPLNEQLQIHMVQGDEYTHLVGDEHLWLHQEQIEWAGYAGVRDATTTSMPARTADDLPLPSWKEMVELRYGVAPAWWGKGIARAAAEAVMQWAASERDVRRFIAETERENVRSARVLEKMGFTLSGTEYWKEPCEVEWERRVEQAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QC59</accession>
    <name>A0A3D8QC59_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">laccase</fullName>
            <ecNumber evidence="6">1.10.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BP5796_12154</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Lignin degradation and detoxification of lignin-derived products.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 22">
            <text>4 hydroquinone + O2 = 4 benzosemiquinone + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:11276"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17594"/>
            <dbReference type="ChEBI" id="CHEBI:17977"/>
            <dbReference type="EC" id="1.10.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.10.3.2" evidence="6"/>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QC59"/>
    <dbReference type="OrthoDB" id="2121828at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052716">
        <property type="term" value="F:hydroquinone:oxygen oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046274">
        <property type="term" value="P:lignin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13854">
        <property type="entry name" value="CuRO_1_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13880">
        <property type="entry name" value="CuRO_2_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13901">
        <property type="entry name" value="CuRO_3_MaLCC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000021">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000038">
        <property type="entry name" value="Extracellular dihydrogeodin oxidase/laccase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.420:FF:000046">
        <property type="entry name" value="Multicopper oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001117">
        <property type="entry name" value="Cu-oxidase_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033138">
        <property type="entry name" value="Cu_oxidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709">
        <property type="entry name" value="MULTI-COPPER OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11709:SF71">
        <property type="entry name" value="OXIDOREDUCTASE TPCJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00394">
        <property type="entry name" value="Cu-oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00079">
        <property type="entry name" value="MULTICOPPER_OXIDASE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0186">Copper</keyword>
    <keyword evidence="13" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0439">Lignin degradation</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0964">Secreted</keyword>
    <keyword evidence="9 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017606173" description="laccase" evidence="16">
        <location>
            <begin position="17"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="19">
        <location>
            <begin position="74"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="17">
        <location>
            <begin position="196"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="18">
        <location>
            <begin position="421"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RDW59230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="588" mass="64388" checksum="C1E4B221FEAD44D6" modified="2019-01-16" version="1">MKLMLSLLALVVGSAAFALPQEVAKTSLITPRQSCENTPTSRSCWGQYNTDTNYYTTIPNTGNTVEIWLSAEEGICNQDGYKRPCMTFNGTIPGPTIIADWGDDLVVHVTNNLQSNGTTIHWHGVRQLNSVEYDGVPGVTQCPIPPGETFTYKFKVTQYGSSWYHSHASLQYSDGLFGPIIFNGPATSDYDEDLGVLVLQDWSHLTTFIDWSAKEVAGITKVMNNLLINGTNTFNCSAISDSNCVSGGKKYETVFQPGKKYLIRLLNVAIDSQFQFSIDGHQLRVIANDFVPIEPYDTDSVIVSVGQRYDVIVEANATPGDYWLRGGWVPATACQGVANDHPSDMTGIIRYDAASTNSPTSLSTVEVPRTCSDESLAGLVPYVKLDVNNIAGTTVEDVNYQITSASLFQWTINSSSLVVDWSNPTLHQVFNNVSVFPTSYNVVAVDKKSPNEDEWAVLVIENKAAAAFGGIAHPIHLHGHDFWILAQEATMWDGTTTSFKMANPPRRDTAILPARGYLAIAFQLDNPGAWLIHCHIAWHASQGLALELIESEKSISVGSADRKVFDDTCSSWSSWSPGAEWQQSDSGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QE91</accession>
    <name>A0A3D8QE91_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative inorganic phosphate transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_11745</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QE91"/>
    <dbReference type="OrthoDB" id="433512at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="378"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="475"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="503"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="90"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="591"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW60139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="634" mass="71408" checksum="CA3B3D672842A3D7" modified="2019-01-16" version="1">MADQVQADAAPEAQHPATLSPSEESEVFQSMLYPDDIYTPEGVYWADLPVGQRISFVTSTDNAEVAKELGQIGAMMKKDPLSPIGWYFRNAVVPGAGLGLEGYVLFSIGNLTSLFNVVWKDCWKSYKTCNKNWVAAVTYLEIIGIIVGQVLVGLLGDGIGRRWGLVQDAIIMFIGLLWLTAAWGLNTEGWVICYAWGLFFYSIGVGGEYPMTVTAAMENAQTGRVSDRNDRLHRGRNVTSAFLMQGWGQFFNQVLLILLLLIFHSGSGSPPYSELSAQWTYRVSFAIPAVGTLWLIYYRWYKMPLASKHLQTVKRRNQVTGYDVQSLKLTIYHFGPRLFATAGAWFANDVFFYGNKLFQSTFISVIDPHVGSNVITGWLWNLINVVVSLAGYYLASFLIDNKLYGRKMMQQVGFLVCFITFVVPAFHYKHYTSVAGIKSFQAMYFLSSFFNQFGPNAVTFLVAGEVFPTPIRATAHGFSAACGKLGALLAAVLYNYITTQMRFYVVPWFGLAGMFVTFFFLPDTTGLDLREQERRWQYIREGRSDEYHGIAVHPKHLSVWERLRGQGKHYNPELDRQSKIADMRAEWELRESEKAAQESGEIDDGNEFSPEVHAYFRSTRGKTASENSLEKPAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QHM7</accession>
    <name>A0A3D8QHM7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pre-rRNA-processing protein IPI3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_11197</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 6">Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the WD repeat IPI3/WDR18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QHM7"/>
    <dbReference type="OrthoDB" id="756370at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000929">
        <property type="entry name" value="Ribosomal assembly complex component Ipi3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045227">
        <property type="entry name" value="WDR18/Ipi3/RID3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763">
        <property type="entry name" value="WD-REPEAT PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 5 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="172"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU369067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW61305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="403" mass="43131" checksum="E5F4124BB49F08F2" modified="2019-01-16" version="1">MLSEGFVTSIRAQPKSANTAIAKDVGIHLHTLYPTPKIESTLKKSSTPVNSLAANSTHIFAAQADKAVVHVYSRERGNQEALVSFPERLHSLTLVGDGIVALGTAEGRVILWEVYTGRQISTPAAHLQAISCMVADQTHLITGSEDSNVNVWSIPKLLSLTSSETHEPLRTLSNHRAAITSLALGHSSTSTNICVSASRDNTCIVWNHQSGTLLRTFLLPTTPLCLALDPCDRAVYVGFEDGSLQLLEFTTAAAVLNPLYDTRLQDTPVQVTLPPWTASFNPGACNCLGLSHDGTTLLSGHASGKVARWDTGLRAISGGEVVDLNAPVTNLIMLSPFSESKKIKAITIMKPKLGEGDYILAAQFTGRATREQNQFDRILQGPGFPADVLERAIASFATPSKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QHY1</accession>
    <name>A0A3D8QHY1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative major facilitator superfamily permease-5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_11239</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QHY1"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="196"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="1"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW61347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="397" mass="44276" checksum="9A01E280FF7DD32F" modified="2019-01-16" version="1">MTGLIAHAQNAKQVYVLRAFLGACESSAWPGMMTLFMHWYTPTELAKRMGFYHSCQALGSMMSGAIQVAVIKTLDGRGGLAGWRWLFIIDAIITVCWAFFGFFMIPDLPNRPNPRAFWFSERHAEMSMERLVRHNRAEPKKMSWAGVRRTFTSWVVYFIAVLYIACVLGSYGYSYFSLFLKSLKNPDGTKTWTTAQINAIPIGGGAIQVVFVWVWALLSDFLNTRWTLIVAQAVIGLVPCIIMSIWTSHPAAVALSAAYASYFITYLSLGTAPLIMSWLSDLIPQDPEARSLIVGVAIAGYYAIGAWSQVLVWPAVQAPYYKYGWQSALACWVLVVIMTCILRYIDIKHLRPKRLEFASQLHRPVVDEAASVQGSEDEVTPGVDSKNAAVQVKGSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QI92</accession>
    <name>A0A3D8QI92_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_11397</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QI92"/>
    <dbReference type="OrthoDB" id="10384943at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="238"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW61505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="258" mass="28895" checksum="CA3FEAEC5861C847" modified="2019-01-16" version="1">MTPSVDTPHSLTDMQETVQASPTEQRIPTMTPQPGTQPTDDTGFEVKLPKIYPKGKLNPVFMPPAMKAGSEARQDADMMEESGAENDGERANAWDGKFSITSKGYANKLTSGDGEMHQYHTYPYQHPDYRGDQDQHWPFQSQVRRNTLSFEALGALSACERVDYLSRGIVTPVELMARDIRALIIAKPKAPRPRPTLQHWKGREGLSSWDRARAATRLRRVSDAQRSFGRFEVDTMDVDGGSSSSTDCDVSTDEEEWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QIQ1</accession>
    <name>A0A3D8QIQ1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cytochrome P450-7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BP5796_11473</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QIQ1"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902181">
        <property type="term" value="P:verruculogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000063">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12 13" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12 13" id="KW-0408">Iron</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="14"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDW61581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="516" mass="58172" checksum="DB4F870C7B602BA0" modified="2019-01-16" version="1">MDIVEAPRTVLGAVGYFCTLSLGLAVLFCVGTAIYRLTLDPLAKFPGPKFNAISPIPGIRDLLRGRLAFENKLLHDKYGPVVRVSPNELHFNSVQAWEDIYGHRVGHPNFHKDPVHVGSVEPVVGVTTLTMADDENHARQRRALAHSFSQKALVDQEDIIQDYVSMFIRHLSRMSDDREAFNMVNWLNFTTFDIIGDLAFGEPFGCLESGQFHFWVSLIFEAVKAGAIEQATRRFATAGSAFQNFLLQCIPSTIRDNRRNHLKFSTEKVMRRLANKNTDHKDFIWYILKQREKFNLNQDEIIVNSALFIVAGSETTANALSGMLARLIYNPDVYAKLCAEIRDAFKEEKDIKYEALSALPYLNAVIEEGLRIHPPVPTGLLRTVPKEGDTVDGYWVPGGTAVSVGSWAASHNSENFVDPDSFIPERWLESDNPNSRYAHDKKKAAQPFSLGPRGCIGKHLSYLEMRIILGRLLWNFDLVSVDGAPNWNPANEMGRARAFMTWEKPDLNVKVVRVQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QL39</accession>
    <name>A0A3D8QL39_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aflatoxin biosynthesis ketoreductase nor-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_10814</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QL39"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW62512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="26310" checksum="5AD5C765818A047D" modified="2019-01-16" version="1">MPSKTYLVTGANKGIGNGLVAVLLSRPGTTVIAGVRDPTQQVSKDLGLLPLGEGSKLITLKIDSTSSSDPVEAAKALQMDHGIKTLDVVIANAGTLTHFGPVLTTPPQALLEHFQINAIAPLQLISAMWPLMEASPSPQFYVVSTNIASLELSLQILIPALPYGVSKVAANFMVRKLHLENPSLVSVALHPGWVQTDMGWFAANNVGAKEIPVTIEQSVRGLLDIVDTASREKTSGKFIGYDGAEVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QM45</accession>
    <name>A0A3D8QM45_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Stc1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_11073</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QM45"/>
    <dbReference type="OrthoDB" id="3514033at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024630">
        <property type="entry name" value="Stc1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12898">
        <property type="entry name" value="Stc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Stc1" evidence="2">
        <location>
            <begin position="29"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="162"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="198"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW62771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="334" mass="35611" checksum="E2B7CB80FE73F844" modified="2019-01-16" version="1">MPPNNQKFTDMSSTGRKNLPLLKDTGIHLNAITAKLCCRTCKGEQVHEMECEGPCGLVKVLDDFSKAQRSTGSRWCKACINWKEATEPGVVPVAAPNNDLAPDEEFEYFGSREGTHDPEAGYDSDEDYGMPYGTMNNTLVIGETLQQPQAFLNTATSVTTNGLHTMPANGGHDKRSTHSGSVADSSTASNPYAGRLNAATASVSSWSAADPRRASATGREYRAWNSSGQYVTRHQDVSSTHETTSNFGKDRDAQLFPASGLPLQDAATLAVTAASLVASSRASMASSVPDAKAASRWARPAGRKTAKLKGVVRSPYTPIEQAPRAGGDSGDDYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QM47</accession>
    <name>A0A3D8QM47_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_11070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QM47"/>
    <dbReference type="OrthoDB" id="4448936at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="57"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="169"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW62768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="259" mass="29539" checksum="8C065CBD5521F1B8" modified="2019-01-16" version="1">MSFKESSPDEDVAQDSKDVLIDRLNDLVLRISDERYMEDGAVAAIHKEVDQIEGLMREKSPKAVRSGSQNSSVRHLGVGGKDDEVFWGTPSPTRTSRRRLPESWTKAQANTASQPSDMTTSRATELTTAVDTLATQLSNALSEIKARKEESNHIHDLLVVRCEHAASRILSLEEHISQVEEDYEACQSELKFLRLQLRAMEVQCLRHVPPDEDEELTESIRNWKVDWEDIDRRTKARRKKARIPRPELSTEDSWCTVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQM5</accession>
    <name>A0A3D8QQM5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HhH-GPD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_10618</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQM5"/>
    <dbReference type="OrthoDB" id="10265068at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045138">
        <property type="entry name" value="MeCP2/MBD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074:SF0">
        <property type="entry name" value="METHYL-CPG-BINDING DOMAIN PROTEIN 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15074">
        <property type="entry name" value="METHYL-CPG-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="148"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="285"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="546"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="608"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="824"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="218"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="313"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="402"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="428"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="447"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="481"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="501"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="609"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="657"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="724"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="755"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="825"/>
            <end position="840"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW64116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1154" mass="127685" checksum="CD2ED7922CBE79BB" modified="2019-01-16" version="1">MQNTPHVLPSAKGLMFSQQLQPFAIPQAGTMELDSEAKGLVTKFAKIHLLKLRRQNGPDRRKMYAMDVYQYARTVGPHFGVIWAKEKVIHNEAVFRKYLWSNAQALPRDTVYTGFHNVNAKENADLIATLSMEDAGFWKEIERLQAKNGGSQLTSSQKRKRSNSDASSQPANSEIGEKQRKRQRKRVRKNKDGTLRQPKTITPTDAASLEQSIGSIVSNGTNTNTPSTASSSTEATGKIDPEAEAKKLRKEAKKLRLQQQKQADTETSLAQEIVENVAVQDPVLATKNMENERPGSAATSSTTTSHKVGEKLSRKKKRNQKKLKSTATESTYFASTDGLKSKIVEKKSEDENKEAETDKKPAGSTKARKRNKNKNILTEPPTLHDASKYYPDYPDTEKLSVKTATDVQSQITSTGKNKNETAAKANSSKKEPVPKEKKANLSPMERVAAEMEAEKEAKRVSETVAEESASRITELGPKTTPVEQNNVKPEVLNSTEDNPQKSKRRSRGRRSIGQTQVEDSQPEAPPLIDSAEDMVIDTLREAEKLSTETIGSIDNTPIPMDVTEESKNSVEQPAQAVDSAAQGDSLELDNEKPVLAEVEVVATEKLTVEEPVAAAPVAVEQAQLEPTPATEVPETTTKQATPEDEGLPAKSSRRKTNPLTELPNNSQESASGSQPLDVIEQEDVKTAGPQYDLSSELSDPPTTPSSIPQGLLYTPSPAKTPEDATADLEAQQEDDDASQRKSNCGVSKLSFAPKSSHEFVDMPKPKRRKSSPFKNESAGFNMKLEHACEAGEVTDGDLGEASFFEDRMLRSACKAKRAPAKSPYFTPTASVSKTQKSKMTIDTEPATPQRASSVSPSKKSPKKRSPVGIISCIPFPPLSAEHFGLIQEKLASDPFRLLVAVTFLIRTHGKHAIPVFYELMDQYPTPESLVEADKVDIIPIIRHLGLQNQRATTYQTYAKIWLENPPVKGKRYGVRDYPSKGDGRDVKKDEVLDDADERFGWEIGHMTQGPYAIDSWRIFCRDRCRGLALGWNGEGVEDKSFQPEWMRVLPLDKELRAYLRWMWLKEGFEWDPFTGEKEIASEELQKAAMAGRIAWDDMGGMRILDEADAGIMLGDTNALEDQVRVEGPEEVTTVTANKVEMEMHPEQSELSQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQY8</accession>
    <name>A0A3D8QQY8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dimethyl-sulfide monooxygenase-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_10406</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW63904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQY8"/>
    <dbReference type="OrthoDB" id="5561043at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF16">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="6">
        <location>
            <begin position="16"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW63904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="460" mass="50036" checksum="7481D2D014117064" modified="2019-01-16" version="1">MAVDDKFNDSAEATFHGGSGVGTLDPLVLVPAMASVTKNVSFGVTGSTSYINPYILARTISTLDHVSNGRFAWNVVTSYSDTAAKAMGKLQVTGHDRRYEEAHEFMDLVYTLLEGSWEDGASIWSAEKGAYDFSKVHKVNFDGLYHRTVSYGPMHPSPQRTPVLFQAGTSSAGSAFAAKHAEAIFCGGHKPSETKRIVDSIRAAAAANGRDPNHVKFFPQITPILGRTVEEAQAKYEKALANVDYAGGLAKMSGYLGVDFGQYPLDEPFVLDDSKPDSGIHAMITALQRYSDLPMTPRRIGQQMAFCGFAAMPVGTPEMVADVFEEWANEGDIDGFNIAYVSNPMSYEDIVELLVPVLQERGIMWKDYTVPGGTFRENLLREPGTSKMPDCHVAAQFRYENLKKQDGVIDGKGDIWIKRKEPPQAESTLPSAPVAATEDAVEKVSKLKVNGTSPTVNAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QTQ7</accession>
    <name>A0A3D8QTQ7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase family 32 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09905</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QTQ7"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF8">
        <property type="entry name" value="TRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW65213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="30429" checksum="49C8BF8A93640B2F" modified="2019-01-16" version="1">MLSTPSSEFPKLIWQTSNDKAKDKYANYTATWRDVNPTWKYEWLSDDGATEFVEAHFKHRPAILRFWHDLQVVILRADMLRYLIMLARGGVYGDIDTTNPIAIEEWIPPNLRHVEINAIVGIEYDDTTFKVFGKNISFCQWTLSAKPNHPLFETAIRRVMSNLEYISRMKRVELKDLKLSKDEVLQATGPGLYTDVVMEVLRNQVGENLQLEDFHGQKEPKVFGDILVLPVRGFASGQRHSHSKDSEYGTILVKHHFGKSWYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QU84</accession>
    <name>A0A3D8QU84_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HAUS augmin-like complex subunit 3 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_10027</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QU84"/>
    <dbReference type="OrthoDB" id="5314201at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="352"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW65335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="59532" checksum="5398EA26F1D5A1C7" modified="2019-01-16" version="1">MAQSSMESLLDILRDHDIVFDRDAITSAFANVADRQAIQGWMELYLGQDTLLTKEEATLYKSLLKSGEIDSVSAAQDTALVQSMSEAELAEAVEELKRSTAAIEKQTETLKMQHNAMSTLVKNNTHASKTRSQMDANQIRRWDIEKSQIKQAAEELTETLNYQCLDFEQQMISSENAVKQTLDCILKSDNKLLSSLQKLSGELEPGQSGDDILVSKIRDLCARLIKHTVDGVRTKLDRIYLTALQEPVAEISGDEQPPEGAEMQEELESLYAEILPVSQMATEQQFLEPALKEIEIRNGFVQVRNERAVEYMHGCLTFLVDRLQAFLERAEQLRSHHSTVQAVIGIAKRAMEDVQPRPSEKDSFPASRPQNDTVPASPIRSRHARQRSALYIDDEVEPEQHLLRNLGIYVPPDVASDAARIELLERAVQERTSKLEGHTYNVQKASEKSISTYLRDAQSTLQLLRDSLHAESLYGKVQLLDVDTESAIHILEKEVEDLQDPLTSIDLRKLQDKNVRRDELVQRWSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUL4</accession>
    <name>A0A3D8QUL4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_10063</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUL4"/>
    <dbReference type="OrthoDB" id="2874598at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW65371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="183" mass="20327" checksum="B5E15505A43EC6E0" modified="2019-01-16" version="1">MFGRSKATTSKSSSGNARRERPTLDVPIFFGIMFILSIAEMGFTIDSFQYLQKTHTWASGTEKARLAFLIFSSARTIALSAAYIGFHFAQRFFHTMLHTIFLVISTILWIVSGVLIRQMWGVINCNQGIGGIKGGLTKCHELKIIEIIAWVLAVVSVVAAIPVVMNAMKRRKRQAERKTATSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QY72</accession>
    <name>A0A3D8QY72_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_09377</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QY72"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF3">
        <property type="entry name" value="HEXOSE TRANSPORTER PROTEIN (AFU_ORTHOLOGUE AFUA_8G04480)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="272"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="371"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="24"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW66628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="503" mass="55636" checksum="970B07D17CF40B28" modified="2019-01-16" version="1">MSSAPPDDGIPWYKKSHLRRLNFSIATLVLFSASSGYDGSLMNGLQALPQWQEFMGNPSGAWLGFINASASLGTFTAYPCVAWVCNKYGRKRSIAIGYIFVILGTVLQTTAKSSGQFVVARYCIGQASAWWGGSAPLLITEIAYPSHRGILTAMYNTGWYVGSLLAAWITFGTRNYANSWAWRIPSVAQIFIPAIQILGFLMAPESPRFHTAKGEMEAARQILTKYHAGGEDTELVRYEMAEIEHSIVTEQESNRSSSYMDMFKTPGNRRRLYISVTLGIAAQWNGVGVVSYYLSLVLETAGIKDLTQQTTINGCLQIWNLIFAVGAAFSVDRIGRRSLWLTSCMGMLASYILITALSGSFATTGSAPTGIAVIPCLFVYYAFYDIAFTPILVSYIAEIWTYQLRAKGMAVMQCVTYIAIFFNTFVNPIGLGSIGWKYYIVFAVILVFITINAYFFYPETGGHSLEEIALIFDGPSSSAPRREFVETLHHKGDLEDYSHVEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYT8</accession>
    <name>A0A3D8QYT8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_09589</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYT8"/>
    <dbReference type="OrthoDB" id="3766406at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00646">
        <property type="entry name" value="F-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="2">
        <location>
            <begin position="81"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW66840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="433" mass="49529" checksum="40AB41BB53CAABE5" modified="2019-01-16" version="1">MVQTRRSTRRPVQGESSSFTRFQAPKASGTAPTRQTKRKATQETAQQGRNTVEDKSKKRAKKEHPSYLQRSHDAEHDPNHSIGLLNLPRDIFNEITSWLEPDSVACLSLTCKEILSIMGTESWTQCRSKRHFWDETRSTWTHFRQSFILFLSRDVPHLTLCDVCMTLHPPLKPPREHRETKLTKHCFGQWSIIDYLPSDELGQYNLLWEHILEARELLITESTDKIGSPIELLDGSFTMQRERLNYTLNSSARQIGKNLVLKHEHIFHASSPQASLPVADILSFPVRLCPHQTTSTQKPEKGRYTTSRVPSGLLTHSIAIVLPPSLRAGISEPSRIISLPSSEKKQMDSVVSGVNPLWKCRACPTKWRVQHSTEGAGELKITAYHSFGDTAYRAQEYWKMLVRREAPNLGSEKRNSEFFVVTRQYLDFAVDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYV5</accession>
    <name>A0A3D8QYV5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Myosin class II heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_09762</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW67013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1293114at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083:SF0">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32083">
        <property type="entry name" value="CILIA AND FLAGELLA-ASSOCIATED PROTEIN 58-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="20"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="178"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="288"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="618"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="685"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="800"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="959"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1240"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1399"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1452"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2138"/>
            <end position="2255"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1534"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1636"/>
            <end position="1857"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1920"/>
            <end position="1954"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="2003"/>
            <end position="2030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="115"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="316"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="685"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1070"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1119"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1244"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1455"/>
            <end position="1471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2141"/>
            <end position="2157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2175"/>
            <end position="2187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="2242"/>
            <end position="2255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW67013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2255" mass="248769" checksum="13F306472ED2AFB3" modified="2019-01-16" version="1">MRLEVNLAGVQYPVIISTTITSSLPPSSPPPAAAAQDGSHRQDPHSPRSPAFSTSSTADDVGSSPVLPPLPPPSFNGRSDLLRTPPRSEVGSQYYTASWGSPYQQPTGSQRARTRSPSRSLSSDPSGDSPIRHLEFHTPYLRPVPAPRSHSDFGDSSSHYGVSASVLAARARRPAQGLTEDWIRQHTVGESTEGHNWLSDDPGESEHSSLSGSISGENLDPMQETDPRTPTLKSFLGKSEQARFDRIQALSGLLKKKSSTETLKQSDYSQAPIPRMELDGAEMELMSSPLRDNQRPPPPPPKDEAPEWRAAAMPKPFNPPVPTLSPAPVPPRLKKKVPWKGKNIMVLLPLDEERGKRGKAPIPMREKDVVAMLKDWEQLGYDTTGFNISHDHDTEAGYEGQSRSVWPNAEDVLQERAQRSFRVSIPNRSEWDAYVRELSEAKLRALGVTLGDEEPAVPPPPPINRRMSTQYPQLPFSPPIPPSSGASSRGNNPFSPPLIPGIGIPASQSSINGSIASPASMQSFSQAKFNPRASVSFSSGAHPFGSPFEFGQQSPSFSPGHMLNQSISFARGGSPNLQNLGAMISPSSPFQEGYFPGDNTLAQLQQRQQQLQAQINQQQIQMRSSANPSPRLQELREADDEEATQLAKSPSKTPEARVNGHNPSASLQKEIDDAEYHLEEQFQRQLEHEDYSPHSDREGQDLSHRRNKSSVENIGGLASSRYAEDTNGPILHHPQPHSRGHSLSQQPYQEGDGSSSDAASKDILRGLKSADNLNFSDADTNPSNMGTPVPMSGFSSHDRNFSTISNPWVDADSQGSKPQRPRHGSKPSMSTLNVEAKEFKFEPSKATFTPGQFSFTGTTFSPSAANFAPTVPLSATSSHFSHRSTGSRINVEAPAFTPGHSEFNFSTSGPSFRADAPAFTPYGGNFSDSIGSGNEAPVPGSIFGNIDLTHIGIVKPSKKSKAITIVRPDSGPKEDDEVMEGKDGRITQGEGRIKRARGGKDDGDSVPLFAEPSMPLGETLRGQSPPKETQSAVLTQADKENSEPAPSEDETLPDTSLQFPRPEPFNEGSEEVKDFVPFEFHQQKQAEDFNAARPFTSKRYSGGLQPYGIPASPEQNKAAPEEPKAERPKTHRKNTSSLSATAKPFEFRPGAFTFSTEPPKPLPEAPVFVPSAGLLSSRYAKSPTPSREESPEVQLEPEEISQFQDSLPGPASPHNFAREATSDHEPTFEEIDAVMRQLNEVENENASRQVDSSPRWQQSSPNRLLPVQDLADSSPIRLAPQNLMRSDAPSPSPARFRALPDMGTMGTNVFARAQDDVFVGESATNLTFDSPIHHLNTTGSVAASDWDDVISEAEEAKLQPRAGFFDSHVNEIVGGILEERLDPLEKALESIQMSLEMMANRAPSRRRDARSLSGELPSDADDEDDEFPPRRSISPRRDRKMEKIRTIITEALASHQLSSRPQSSAAPSVVPENNSNVLRVLEEMKESFGASLRLDLRGEDLRNVVEQAVEARMPQQPPVDELALAKTAEDKARISDLEEILRRADLKIEDQIKERRAAEDRLAEVQRLLRISSEEEIRLREALDDRDDKIRVISQERDQKVRDAEDARVEVTMRNVHLEAAQEHALKTQSDLHSRLAIAEDDLHDANEKVQRWQIEAERALEAAKRHSDDAEQANETNRDLRRTIETLRTQMEESIRVREGMRGKLMGLQEDMANAARNIAEENARRAKREAELVARQEVLDAKLQAEARTRERLEMEIERLETGERDGMRAVNECKKLELLLSELRQENHVAQQDAMKFKREYEEARESGLSEVQRTKYYMQAEIEAANNQVNVARDDLETQLARARVEVDQVKLDADTTKAKYEMLLEEVNSSKIAILEDLTNKHANEVEDIHTQHERQLSNAVEDAQRSEQHLLERLTLSSAKNDHLQDRVQHLEEKLEVAKAAAHAAANAARSERSVSGGSYQSAVSAAPVQLEVPKPARDPRLELPEKISPQALRESIMVLQEQLQDREKKIEELEQNLSTVDLDAPNKITKRDDEIMWLRELLAVRKGDLQDIVKTLSNDDFDPETVKDAAIRLNANLQMEEQERERAMNGGSALNLPNIAASLAASPRVAQAVGPLAAAWGNWRKNRDSVSEVAGSSATPAKNTPGSQGFLSGLLTPPASARTPPGSQPTAFRRSNQRFSAEQLANRPKSMTPRQQGKMPMRGSPKRGPPATPPMMRKSSYDLDATAASGSDFGFDVDEDDDSVVDYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QZ78</accession>
    <name>A0A3D8QZ78_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_09826</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW67077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QZ78"/>
    <dbReference type="OrthoDB" id="4329349at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="13"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW67077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="325" mass="35490" checksum="DB111ED350F39AA3" modified="2019-01-16" version="1">MSEKDPEFVIEEWSLYGLGAVMIMIRFAVRLRVVGWRHFRGDDCMAILVLTFFTMGVANSYIICGDEPVKPRHLLLTDSEISTYEYGSKEELAAWVTPDPGPKCTLKLQNFLVTTILNILKLVIFLLLPSGLFIITAAIIRVVLTLSAHPSALNINRWGNREVFVGIITINIPILRPLFTTDFWRLHPCDSAGSHASAGNARAEFHGSPYVLSSGSSSTHHASPKSSPHAGRTKFAHSDDDSLNRMVLAGGHNDTYPFREFQPAAAPSSEGVRVHTTYEGVSEPMADVERTAGGCTRWDYSSGWVAPASPTCCVCGAVCGGCSEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QZF8</accession>
    <name>A0A3D8QZF8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_09703</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>a diacylglycerol + H2O = a monoacylglycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32731"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:18035"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a monoacylglycerol + H2O = glycerol + a fatty acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15245"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17408"/>
            <dbReference type="ChEBI" id="CHEBI:17754"/>
            <dbReference type="ChEBI" id="CHEBI:28868"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. Lipase family. Class 3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QZF8"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051218">
        <property type="entry name" value="Sec_MonoDiacylglyc_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45856:SF24">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="4">
        <location>
            <begin position="166"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00043996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00047591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW66954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="397" mass="44068" checksum="1AC15D7200670B39" modified="2019-01-16" version="1">MPREQSEWNKSIERGIDTLLHHRPLTVSVDISASVLQTSNLAESTQSTSNSLAASKAIHHARERLNQTLVQGEDDEEINYAPDPKVLDYIANIERYSNHKLPDKLTPCHFSYLDWQKVCLAAQAAKSIHKMTPTSGDALFFPGSTFGTFKSFAVSKNTYSGAQYLIVAIRATRTTWDWMVNLNAEPTEYTEFGNRFKCHRGFLLVAQNMKASVEKSIMEHLSTLVGPTNVIFAGHSAGAAVAQLLFTFIRTHPAADLVANVLGPNVSQMDCITFGGPPTSFPPLPIPPSCLFLDFKNEGDPVTLAQPDYIESLLQAYVLKPPRTSSVWAVPGPLYYSSGDQILLRDVAGEDSDEEHPAAFRVDHDETKSIIFGNPVRHSMSLYLKRVETIRDRFLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R2K5</accession>
    <name>A0A3D8R2K5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">OPT oligopeptide transporter-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_08873</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R2K5"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="293"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="648"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="696"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="734"/>
            <end position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW68216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="805" mass="90126" checksum="29772BF8051BBA46" modified="2019-01-16" version="1">MLPTTNEKVVLGSVEEVKTPATANSPADIFKEKHQFNLSLDESDRGNASDDEPQYDFSSEEFANIPELVRNIVGFEDDPTISVITFRSLLLSAIFCALGSVVSQLSYFRTTTAPFPIFFVILASAPLGRLLARVLPAYTVPLGRFSFSLNPGPFSIKEHAIIGIAANAGSQGQWATYLPTNAALYYGITMNPAVALFFGWGASLLGFAFAAMVRKILIDDPEFIFPLSLQQVTLYRAMQGENETHKATSKRRMNVFWLLLLGTFVWQFLPEYLFPFVASLAPLCWFASQNHVVNFLGAGRGGIGLLNITLDWSNITSTVITYPYSVQVTVFVGFVITTWILIPVAYFGNIWGSPTYDIMSNGVFTKNGSSYPFNSLIYTDASGIQRVNETKYEEVGLAYSGVQYTWEIFMWYASYISSFVWCGLFLAPKFISLWRARKQLGQYHTDRLSRIIQKYPEMTKWEWGILTAVPIIILLILVATNSVWMPTWTYFVALAFGAAAMLPMGLVYAVSGYSIKVGLFNELVYGYMIDAKGSSRHPLGQLAYRIISGNVWYDARVVLEDQKIGHYLHLPPRDVIGMQIVANMIALPVNYGVMRWVLASKFDYVSGKVTDPSGQWTGQDFKSYNTAGIQYALVGPKKLFASSYFSPVQYGLLAGAVAPAIIWILHQKLPKFRFHLWNTTIFFASSATFYGNLSTGPFTAILIGTFFNFYLYRYKHEFWNKWAYIIGAALDTGYNANLLFIFIFLGTTGTVMVHWWGNNADIPGYQYEFAAIRVLGLGLKPTAPRAQIATSEEFCIYQQPIDSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R3E2</accession>
    <name>A0A3D8R3E2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R3E2"/>
    <dbReference type="OrthoDB" id="2588190at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02215">
        <property type="entry name" value="cupin_QDO_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053146">
        <property type="entry name" value="QDO-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36440">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36440:SF1">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_8G07350)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="1">
        <location>
            <begin position="63"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW68334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="349" mass="38199" checksum="415AF36E2F446A05" modified="2019-01-16" version="1">MPIETLTSPPGKTGQAYVIPCYSGELWTIPTSNSTMRLLVSGKETDNAFAVVGTGGTFDKPIGFHFHKEAHDVFLCLKGRINVWANDKARSLYPGDFASVPPGTIHQYQIDAAHAEFIGLIIPGGWEEFFRFIGEPYSGPLFPTNDKRNPFEVLIPKLMAATEKFDMIPVRDKAQFEPQPWDGSENKLPGLCENGGYYLKDGAGEKYIVGNTVVRPMATRKETNGRFSIYELQGSKLNGDRKALTVEFAETHHAIFTVEGVLKLTVDGSEVKTTASETSFVPAGSKWSLEVESPWARVYVFANGGGVGEIFTTTGTKYEGVAVPGIEEGKASDTSKLKDLAEELKFLVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R3Q7</accession>
    <name>A0A3D8R3Q7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_09245</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R3Q7"/>
    <dbReference type="OrthoDB" id="3172332at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF4">
        <property type="entry name" value="HYPOTHETICAL CONSERVED PROTEIN (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="55"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW68588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="601" mass="67159" checksum="3071DBB28CE85B24" modified="2019-01-16" version="1">MKKSELLLVDRSLSSGAGVSARPPTEAATDPLYEHGRAPSGSRRIRAKAAKVKTGCRNCKIRRIKCDEGQPGCQRCWKYGIYCSGYSWPTKSHQAESRVLAPMRNGSQISLRAICPRYVEPAQLTLLPFPGSNKDEMECRYFGYYLEDIATKIGGPGFSDLWVKVIPQVGDTHPYIAQAIVALGALSRSRQVQDKAQQIQHRVYALAKHVESLSGMRKVLYQDGYDKRIAMHACLLIFCFESLQGHQAAASMHAAGGVSLLESWNHERNFKGAMELGDTVGDSSSLSYAIACLDFQALAFVDARSADLHKHTAQRLKKWIKSMPTIYGPTGHFKSLDDCRTYGHMIMRRTFHFIRTVRIYLARNNRSFVMPNADGETANLHPGNNTWTSGPVRASEVPEEMLQEYNEHMDDIRRWQVAAEPVIAQARRIKDSDQFTSATVALIRCTMTILTLAGTLIDEGEYDKYIVEFREITSLVTSVWAAVTRTRNPFTFQTGMLPALLLVGMHCRDREIRDQAISLMSSGEGYREGIWDSIAIGKISVALRDLEEKWVDADGHIPGEMRALLVSCSIMLEEKTAQLVITQKAAPGDTNYQVKPVSLAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R782</accession>
    <name>A0A3D8R782_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_08300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW69903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R782"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF23">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="325"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW69903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="427" mass="45704" checksum="166ED1ECBD36D698" modified="2019-01-16" version="1">MDHLPKLDHDAHVAGSSHHSNGFFDTPLPPTGTEHRSSAKKGFFRKDDDSDGHSADHSLEAMGYQAELIRSRSTLQVAFMSFVLASIPYGLATTFYYPLVGGGPANVIWGWVLTFAIFWTFAGVIAIVVCVLAIAKEGRRSAKYVFTDFEPSSGWPDGWSFCVGLLQAAYATSSTGMIISMCEEVQYPSTQVPKAMVGTIILNFFAGLLILIPLLFVLPDLAGLVALASGQPVPTIIASAVGSPGGAFGLLIPLLVLAIFCGIGCTTATSRCAWAFARDGAIPGSQWWSKVNKRLDVPLNAMMLSMIIQILLGCLYFGSAAAFNAFSGVGVICLTVSYAVPISTSLFNGRTHIKEGKFDMGMLGLVCNIVAIGWSLLAVPLFCMPSYLPVEAATMNYASVVFVAFFAIAAGWYFAWGRKHYAGPPMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7H7</accession>
    <name>A0A3D8R7H7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">mRNA-capping enzyme subunit beta</fullName>
            <ecNumber evidence="8">3.6.1.74</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-phosphatase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8">mRNA 5'-triphosphate monophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_08323</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67004"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
            <dbReference type="EC" id="3.6.1.74"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:67005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the fungal TPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.74" evidence="8"/>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW69926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7H7"/>
    <dbReference type="OrthoDB" id="272147at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031533">
        <property type="term" value="C:mRNA capping enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140818">
        <property type="term" value="F:mRNA 5'-triphosphate monophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07470">
        <property type="entry name" value="CYTH-like_mRNA_RTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.10">
        <property type="entry name" value="mRNA triphosphatase Cet1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040343">
        <property type="entry name" value="Cet1/Ctl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004206">
        <property type="entry name" value="mRNA_triPase_Cet1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037009">
        <property type="entry name" value="mRNA_triPase_Cet1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118:SF1">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE CTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28118">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-TRIPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02940">
        <property type="entry name" value="mRNA_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="4 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="mRNA triphosphatase Cet1-like" evidence="10">
        <location>
            <begin position="486"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="422"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="185"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="222"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="247"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="298"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="370"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU367053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW69926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="773" mass="84964" checksum="12EC285F55C2DFFA" modified="2019-01-16" version="1">MDLRSIINTEGGDGSASKVAAPVTPVQAVSQQSFREYSHPPHASPSKHPPADYGSRSGGPYASPTPYQSQGNYQGRPGQPPPLQTANHNDIRSPAASYTAQSPYRQTPNSSVGGGQYPFPQTHQSPVQAHQYPPPQQQQAQHRDSYQQTAHLQHQNSHGQGSITPQTPPVGIPGAPHPYLQHQRSQSSISVSTPTSAHSQQQYFGNQQQQDSPISVHQFPVQSLPQHQRQSSQQSHPGTPLGPPIQAQRQSSGGFMQPTSPYQQRGMSAGTVSQYQTSPAPPPPAAIPRLPSTPSAYESHRTSTSENFRRSQSERERSLSVSPKTRLPSQTPSNSRESFSILHEQPEVGPSASAKRKLSDRESPVEQRQFVEQVSKPQVNGNHQSTPAPASSTQRPQQPPAKKKMRYTEPPIWARSVRGGFKSSGIKVNGRPGVSGESTPPPTQTEANGHRHVSPAVGRSGPPSTTGACGLLGAWEESISGIKPVEELSRLVADWLYGKVVSRSDIGELQVRGVEVEIEAKLGQLINKDTNERYRLPVESECLLSESGRVGFKSSMTETQHKALNEFLNQQVTETHPENPRQATKKRVPIGYRHRRERDRFFELPASAQAMLPPAIRAELNPRHTVKVRVTHDQKTNQLLAKIVKARVADLDMYCPQSVLDCRISVNLEMRYDGDIEGLIGGEGTRLPDRNKDRLSYTQSHYQIDLTQVTQVTSINGVSKVDKEHELEIELSAAALREQGRRATAGEPNEYIKLVEGLMDNVRVLSRKASQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R853</accession>
    <name>A0A3D8R853_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative ras-related GTP-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_08624</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Endomembrane system</location>
            <topology evidence="11">Lipid-anchor</topology>
            <orientation evidence="11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the small GTPase superfamily. Rheb family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R853"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04137">
        <property type="entry name" value="RheB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000273">
        <property type="entry name" value="GTP-binding protein Rheb homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0488">Methylation</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0636">Prenylation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00037969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW70227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="187" mass="20988" checksum="681418D4FE7BDA04" modified="2019-01-16" version="1">MPAPPKQRKIAIVGSRSVGKSSLTVQFVDGHFVESYYPTIENTFSKVIKFKGQEYATEIIDTAGQDEYSILNSKHFIGIHGYMLVYSVASMQSFEMIRVIRDKILNHLGTEWVPVVIVGNKSDLRPEQRQVTVEDGKSLAAEFECAYTEASARYNENVTKAFEQMIGQIEKSQNPNEPTGGNKCQIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8R5</accession>
    <name>A0A3D8R8R5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoserine transaminase</fullName>
            <ecNumber evidence="4">2.6.1.52</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_08839</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>4-(phosphooxy)-L-threonine + 2-oxoglutarate = (R)-3-hydroxy-2-oxo-4-phosphooxybutanoate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:16573"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58452"/>
            <dbReference type="ChEBI" id="CHEBI:58538"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-serine + 2-oxoglutarate = 3-phosphooxypyruvate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:14329"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:57524"/>
            <dbReference type="EC" id="2.6.1.52"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.52" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8R5"/>
    <dbReference type="OrthoDB" id="1703350at2759"/>
    <dbReference type="UniPathway" id="UPA00135">
        <property type="reaction ID" value="UER00197"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004648">
        <property type="term" value="F:O-phospho-L-serine:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000082">
        <property type="entry name" value="Phosphoserine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000006">
        <property type="entry name" value="Phosphoserine aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00160">
        <property type="entry name" value="SerC_aminotrans_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022278">
        <property type="entry name" value="Pser_aminoTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003764">
        <property type="entry name" value="PRK05355.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43247:SF1">
        <property type="entry name" value="PHOSPHOSERINE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0718">Serine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="12">
        <location>
            <begin position="9"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class V" evidence="12">
        <location>
            <begin position="117"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW70442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="430" mass="46864" checksum="DB4B1129AE710292" modified="2019-01-16" version="1">MTQREEITYFGAGPALLPTPVLQTAAQALVNYNGTGLGLAEHSHRSKIAEDVLNTAKADLATYLDIPDDYEVLFMQGGGSGEFSATVYNMVGIWVEKRKQKILKELGITNGKDISEDVIATELRKAVEEELKIDYLVTGSWSLKASQEAARLLGPEHVNIATDARKINDGKFGKIPEEKSWNLSRNPAMVYYCDNETVDGVEFPGFPEVLKSNGQDEEPIVVADMSSNILSRRIPVKNFSLIFFGAQKNLGCTGVTVVIIKKSLLPPTVATPSPSLMRKLGLPIGPIVLSYETIAKNNSLYNTLSIFDVYIAGQVLKSLLKTFSDKVDGQQAIAEKKANLIYAALDAHSNVYKVVSDKSARSRMNICFRVTKSQDTNESEKQFIAGAEKIGLTGLKGHRSVGGIRASNYNSISLEGAEKLAAFINSFAET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8Z0</accession>
    <name>A0A3D8R8Z0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_08721</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8Z0"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002343">
        <property type="entry name" value="Zinc finger protein 33A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000016">
        <property type="entry name" value="zinc finger protein 37 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050329">
        <property type="entry name" value="GLI_C2H2-zinc-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818:SF139">
        <property type="entry name" value="PAIR-RULE PROTEIN ODD-PAIRED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19818">
        <property type="entry name" value="ZINC FINGER PROTEIN ZIC AND GLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="173"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="203"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="7">
        <location>
            <begin position="261"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="148"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW70324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="417" mass="46953" checksum="D4911A7027CA4F00" modified="2019-01-16" version="1">MAPQYIAVAQPYSGPGANTLVAHSQQMEQLQRQNNPFTYPVYNNGSNGIAPVFPVNYIRSRPQHPTEMQQNAYTPRSVHQGYLDTRYHQQSQSPPLKIEPLPAITRSPIHEPGNIKTINPILQGTGSSQDFKTEVDTLMKAIQAKVEVAKQPSDAEARRSSGRSRAKATKKKHRCTFENCDQVFGQKTHLDIHARCHTGEKPYACPWPNCHHTFSQHGNMKTHLRRHSGEKPYPCAECGRTFAQKGNVAAHQAIHTQAKPFLCLLDNCKKKFTQRGNLKSHMNKFHKPSLLAYTTKFASYQPGDYVSETDREMWKYFADMYKNSNKGIKGRGKDRKVSSSSDRLVARMRDLKVMHNESVRYNGGHMNNMAYDMYAVDSRSNSASCQSSQTGGSPCYTTCDSFEDTGKAALTFGESMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R928</accession>
    <name>A0A3D8R928_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08788</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R928"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053185">
        <property type="entry name" value="SET_domain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332:SF6">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47332">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="134"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW70391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="425" mass="47565" checksum="D95E075DA688FA54" modified="2019-01-16" version="1">MRYPTILSSLALISYSRASQPHYTHSQLAGICNVADNNNVLSFGQKTFGLDHESCTHSRVDVQNTPVYHPWTHKPRCTPKNGLNETYCVYTNSNFADGRGISFLTSPLVAKEIINLPAFTNPEIPENVNTFTDPPWEVRNIPGRGNGLFATRTLYRGEEILAATPVGVYMSDAFPVDYGLGYQYLNTAYKQLPKATREKVMMMAAHNAGDPIMERVNTNSFSGEFGGEPHFIVYPETARMNHDCRPNAMYYYDPATLIHSTHASRTILPGEEITITYINILQPRADRQEVLEMTWHFQCTCPLCTSSDEEVAISDARMQRIHEIHATLADWSPNTMATPELAEELITLYELEKLHAAVATGHMFASMAYNAIGDTDRAKQFAERALKAGMVNSGVNGGNSDVDDMRAMLRDAESHWSYLARPRKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R9A6</accession>
    <name>A0A3D8R9A6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7702 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_08841</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R9A6"/>
    <dbReference type="OrthoDB" id="2560628at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056119">
        <property type="entry name" value="DUF7702"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109:SF2">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42109">
        <property type="entry name" value="UNPLACED GENOMIC SCAFFOLD UM_SCAF_CONTIG_1.265, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24800">
        <property type="entry name" value="DUF7702"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7702" evidence="2">
        <location>
            <begin position="1"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW70444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="190" mass="21119" checksum="56B54CF0BAB195CE" modified="2019-01-16" version="1">MLSFIGILHESNHYIRGLKPVLLTIIPALIFHIVVVGAMVLIILGYQSNQNQGPALQKIGYILFVTIFLAVALLTGLSWRITNRGNGPHKLLIAIAIALPFLGVRVFYSLVSAFDHDINAYTGPITYRVCLAILMEFVMVVVFAVFGVMSRNLRAEEQVYSTTGENASDHDVELVPEGGNRKRWLQARRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RD68</accession>
    <name>A0A3D8RD68_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">L-galactonate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_07902</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RD68"/>
    <dbReference type="OrthoDB" id="14161at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050023">
        <property type="term" value="F:L-fuconate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03324">
        <property type="entry name" value="rTSbeta_L-fuconate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000007">
        <property type="entry name" value="Mitochondrial enolase superfamily member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034610">
        <property type="entry name" value="L-fuconate_dehydratase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046945">
        <property type="entry name" value="RHMD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794">
        <property type="entry name" value="ENOLASE SUPERFAMILY, MANDELATE RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13794:SF58">
        <property type="entry name" value="MITOCHONDRIAL ENOLASE SUPERFAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00111">
        <property type="entry name" value="L-fuconate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00270">
        <property type="entry name" value="L-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00909">
        <property type="entry name" value="MR_MLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="5">
        <location>
            <begin position="200"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW71868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="450" mass="50235" checksum="2101AFBD886A9F44" modified="2019-01-16" version="1">MAEITITGWDSRDVRFPTSLDKTGSDAMNAAGDYSAAYCILQTDSKFSGHGMTFTIGRGNDIVCKAIDNVADRIKGRTLSSLVEDWGKTWRYLVSDSQLRWIGPEKGVIHLALGAVVNAIWDLWAKTLNKPVWRIVADMSPDEFVRCIDFRYITDAVTPEEAIEMLKKEESGKEKRIQDALNNRAVPAYTTSAGWLGYGEEKMKGLLEETLSKGYKHFKLKVGTSVEADKRRLSIARSVIGYDKGNILMVDANQVWSVPEAIEYMQHLKEFKPWFIEEPTSPDDILGHKAIRDALRPHGIGVATGEMCQNRVIFKQLLASGAIDVCQIDACRMGGVNEVLAVLLMAKKYNVPIVPHSGGVGLPEYTQHLSTIDYVVVSGKLSVLEYVDHLHEHFQHPSVIKDGYYQTPTEAGYSVEMKPESMEQFSFPGKDGVSWWKSEEAKPILEGIKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RD94</accession>
    <name>A0A3D8RD94_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SUZ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_07974</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RD94"/>
    <dbReference type="OrthoDB" id="5422283at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW71940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="23338" checksum="7F67D2249847F651" modified="2019-01-16" version="1">MSKKAAVPDAWDDDWEAQADKADELAEKAAADIKVEEQVKISKAERLARHADENKKLWESAEAPETPFFLAARDTVPLKSEFKPALKVLSRKPAPKVIARHDPVTGVAQMTIDDDDDEEETKKDQPTPEELKLIAERQRLEKQKRYDEARARIMGTGSGPSTPGTVTPPSNTEDSNSKSSRGKGRGRGGNRSENSRPSSQTGTKELLWFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDA2</accession>
    <name>A0A3D8RDA2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF833-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_07888</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDA2"/>
    <dbReference type="OrthoDB" id="191601at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008551">
        <property type="entry name" value="TANGO2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985">
        <property type="entry name" value="SER/THR-RICH PROTEIN T10 IN DGCR REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17985:SF8">
        <property type="entry name" value="TRANSPORT AND GOLGI ORGANIZATION PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05742">
        <property type="entry name" value="TANGO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW71854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="357" mass="39699" checksum="F19BD1EF665534E1" modified="2019-01-16" version="1">MCIALITTAHPSYALIILDNRDEFILRPTSLPHWWTSVNNNQQVLSSRDLLRPEQGTWLGITKSGNFAVLTNFRETDDPLHPIQGLKSRGGMVTAWLGAEEEVDTATFVRRLFEDGGVKGVGGFSLVAGKLRRDGAGGIEPLAVISNRSGGVEDVPWIAGERDQVHGLSNTSFHDPKVWPKVRMGKEMISAITEQAANERWDEEKLVNALFQALDTDTLPPAKEDEAFEEYLSQLRESVFIPPIGSENPDEIPEADVIAAAKPIENGHATHGDVKLINATKEAEKAKNFMSGVYGTQRQTIILVDWDGKVTFRERALYDEYGKPIERGHGDQKFEFKIEGWEGKFNGCLRTRGVEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDH0</accession>
    <name>A0A3D8RDH0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Myb-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_08137</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDH0"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF238">
        <property type="entry name" value="MYB-LIKE TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="95"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="95"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW72103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="23523" checksum="DADD9EBA1616FDDF" modified="2019-01-16" version="1">MSTRGAGQKAESTSGPSNPPTPVKPTSAAAAVAGEESSPKQEVLSQPGRNKRRASGTGTSSMASNTLPASTGPAEASGSGMGETSTDSPAMPPAKKSRTNTPWTPAEEQRLKVMRDAGNSWADIAKTFPSRTEGSVKKHWYKDMHYAEFAEDESQALLNAIKEYETNKWKVIGAKVGKPAKVSLAKVLKRGCLLSLIALFVSNDENNQMDGIIIAGFTVDRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIC7</accession>
    <name>A0A3D8RIC7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_07251</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIC7"/>
    <dbReference type="OrthoDB" id="4314040at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF13">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW73809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="608" mass="67612" checksum="F53506CFC1186299" modified="2019-01-16" version="1">MNCEKLKKECPGYRSAIDTILRNETKATERKARARKPRKTSKTLPEFDWTSVSSGGSHGGHSRSSSISSNSSICSDAVSRSAESPEDSSNWLVRSSPQSRPSSMYQQLSVPIEQQATNYFFSNFVLLPKGNNNFGYMTYLLPLMKMHDPGSTFALSLNAVALASFGNRSYSKALLPRASQEYAKALRQVNAALRDPELVKLDHTLASVLLLGLFETICSSKVHMGWNDHMNGAVALVKMRGTDIPTNAVTRELHLTVRAQMIPYCILNSRSLDLPVEWWMSLSLEGMHGCNDTNLKVVDLRTRTEAVISVAQRTPANFEKVLDIMHRAEALENEYLEWIKSLPAHWLFKTVAWNDNMSEEELASSNCFSGKVDMYAGMWMANLWNMSRACRLLLSQITVRCTAWLCAPRDYRTTPEYRKAARLCEELIGDTIASVPNFLGGLPRNDTTKDIDTGFAFPCGEDTGTAGKGISGLFLLWPLIAAATSDFATEAQRKWMITKLQFVGDSIGINQGAVYSGFHVRQPSMKIESDRSVFNKMKDASESISFANWPQSKNLDGMTRGTFLSRQLYPPPWLIRHREVEAAGRATHSGTPSELERVEGSGVSAPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIV7</accession>
    <name>A0A3D8RIV7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="9">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_07223</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 8 9">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="9"/>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIV7"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000097">
        <property type="entry name" value="Serine hydroxymethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF28">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="7 8 9" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="10">
        <location>
            <begin position="23"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="8">
        <location>
            <position position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW73781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="480" mass="52932" checksum="2EB2AC2538648E52" modified="2019-01-16" version="1">MATTGTYALPKSHQEMLEKSLIETDPEIAEIMKLEIQRQRESIILIASENVTSRAVFDALGSPMSNKYSEGYPGARYYGGNQHIDSIELTCQARALKAFNLDNQKWGVNVQCLSGSPANLQVYQAIMRPHDRLMGLDLPHGGHLSHGYQTPQRKISAVSTYFETFPYRVNLETGIIDYDRLEENALMYRPKVLVAGTSAYCRLIDYARMRKIADAVGAYLVVDMAHISGLIAAGVIPSPFEYADIVTTTTHKSLRGPRGAMIFFRKGVRSVDAKTQKETLYDLEGPINFSVFPGHQGGPHNHTITALAVALKQATTPEFKQYQEQVVKNAKALEVEFKKLGYKLVADGTDSHMVLLDLRSHALDGARVEAVLEQVNIACNKNSTPGDKSALTPNGIRIGTPAMTSRGFGEADFQRVADYINQSIIICKEVQAALPKSDNKLKDFKAKVAGGEVEKINVLQKEIAAWAGSFPLPVEGWRTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIX6</accession>
    <name>A0A3D8RIX6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">UTP--glucose-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="3 7">2.7.7.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_07434</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a central role as a glucosyl donor in cellular metabolic pathways.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>alpha-D-glucose 1-phosphate + UTP + H(+) = UDP-alpha-D-glucose + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19889"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.7.7.9"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.9" evidence="3 7"/>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIX6"/>
    <dbReference type="OrthoDB" id="932129at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003983">
        <property type="term" value="F:UTP:glucose-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006011">
        <property type="term" value="P:UDP-alpha-D-glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00897">
        <property type="entry name" value="UGPase_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000001">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000002">
        <property type="entry name" value="UTP--glucose-1-phosphate uridylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016267">
        <property type="entry name" value="UDPGP_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43511">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000806">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 10" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="142"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="235"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>UTP</name>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR000806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000806-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW73992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="521" mass="58148" checksum="4785E2A352E209DD" modified="2019-01-16" version="1">MARPRSKSLPEATLAGVFFTKPVGRAVLKQILLQAFENTSTSVAASQMRNALNNLADTVTDPEEKKLFETEMDNFFALFRRYLNDKAKSNQLDWERIAPPAPSQVVDYNELANSESVGFLNKLAVLKLNGGLGTSMGCVGPKSVIEVRDGMSFLDLSVRQIEYLNRTYNVNVPFVLMNSFNTDDDTQNIIKKYEGHNIDILTFNQSRYPRILKDSLLPAPKSFQSPISDWYPPGHGDVFESLYNSGILDKLIERGVEIVFLSNVDNLGAVVDLRILQHMVETKAEYIMELTDKTKADVKGGTIIDYEGSVRLLEIAQVPKEHVNEFKSIKKFKYFNTNNIWLNLKAVKRIVENNELEMEIIPNNKSIPADKKGESDVSIVQLETAVGAAIRHFTNAHGVNVPRRRFLPVKTCSDLMLVKSDLYSLKHGQLQIDPNRFGPAPLIKLGNDFKKVSDFQKRIPSIPKIIELDHLTITGAVNLGRGVTLKGTVIIVATEGSTIDVPPGSILENVVVQGSLRLLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJA3</accession>
    <name>A0A3D8RJA3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein YTM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">YTM1</name>
        <name evidence="9" type="ORF">BP5796_07567</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR12/YTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJA3"/>
    <dbReference type="OrthoDB" id="10251381at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000593">
        <property type="entry name" value="Ribosome biogenesis protein ytm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03029">
        <property type="entry name" value="WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028599">
        <property type="entry name" value="WDR12/Ytm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF11">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="8">
        <location>
            <begin position="14"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="168"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="217"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="375"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW74125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="482" mass="51680" checksum="0E8EAF5C96E358BE" modified="2019-01-16" version="1">MDTPMVDAGRQGQVLVYFHTESPDIELPEGKRQLLVPTDVRRYGLSQILNSESMLDTTSPIPFDFLINGTFLRTTLDEYLTANGLSSETTVNLQYVRSLIPPLYEASFEHDDWVSSVDILSSTSVAGTWGKNSVAQGQERILSGSFDGLFRVWNKSGQAIVTSASASAGGHTSSIKAAKFISPTQIASSDMDRVVRVWNYREAEDQLSAKVKPTLELYGHKRSVDCIAVHGPSNRILSASADCSIGLWSTEASSAPAAPPSLLPSAKRRKVTTSVTIPQRGALSMMSMHTAPATAVIFNPLDPTVAYSASQDHTVRTIDLVTSTLVDTRTTSHPLFCLSALPGISSQLLAAGTSARHITLLDPRVSATSNQVMTLRGHTNLVCSIAPDPNSNYGLVSASYDGTCRVWDLRSSRQGTREEGGGSVGEAVYVIDRESQKDASKKPVGGEGVKVFGVAWDKEVGIVSGGEDKMLQINTGRGITKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJB7</accession>
    <name>A0A3D8RJB7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Origin recognition complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_07498</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ORC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJB7"/>
    <dbReference type="OrthoDB" id="10265211at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20704">
        <property type="entry name" value="Orc3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020795">
        <property type="entry name" value="ORC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045663">
        <property type="entry name" value="ORC3_ins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045667">
        <property type="entry name" value="ORC3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040855">
        <property type="entry name" value="ORC_WH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12748:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19675">
        <property type="entry name" value="ORC3_ins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07034">
        <property type="entry name" value="ORC3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18137">
        <property type="entry name" value="WHD_ORC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 3 N-terminal" evidence="10">
        <location>
            <begin position="15"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 3 insertion" evidence="12">
        <location>
            <begin position="135"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 3 winged helix C-terminal" evidence="11">
        <location>
            <begin position="381"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF19675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW74056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="484" mass="55372" checksum="B0CBB2FE5C7816A5" modified="2019-01-16" version="1">MLYFMEISFLADKHISSWRDRIPFVLLFGIATSVDLFHDRLSRRATRCVFGAQFDVEQTSSIVERVFTKVVISADARLRLGSALVSSLMERQYDHVQSVQAFIAALKYSYMCHFYANPLAVFLGMSDDPKAVRKVLQDEHFEALRNLPSFRLRIQDLLEQNEPEHARKMLEDDEKLLDEAMASMNARDHSIRDMLRALHVLASSSKVLSVNVQIFMEAFTGSIYDSGTITKVINAIKRMGPEPLLETTQKIIGAIQEGNQELGLDPWDDDAADFVKSMKDIQVQTEKLVEEADEANVPIRSKYSAQHKVLRTTVIAQKVQLSHDSAKLSHHDVEFTSLVDRLIELLRNYFTIISPQNDFMNEIWLYDHRSPYRDVFTPRPRFVIERALSAPHEYIDTSIEELSSAKPATALLYEMYLENGSLINVFDLWSAFSHQMSSDDDEGNNERETLALFYRALADLKSLGMVKHSKKKTDHLAKLAWKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPA8</accession>
    <name>A0A3D8RPA8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_06609</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPA8"/>
    <dbReference type="OrthoDB" id="2690153at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF8">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21274">
        <property type="entry name" value="Rng_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="7"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW75788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="587" mass="65147" checksum="8B72C91BD1D2F039" modified="2019-01-16" version="1">MALPLELDLLIVGAGPAGAALACFLASHGLTGMMVANTPTTADTPRAHITNMAALECLRDIGLEEECLKVAVDGQNMLHTRWCRSMAGEEFARIYSWGNDPKRAGDYDAASPCKHVDIPQTLLEPILVQHAAHHGFPCRFHTAFLAFEREASGTILSKVEDRLTKQTYEIRSKYLFGCDGARSQVLRQLQIPLIKKPGQGLAMNILIKADLSHLVEHRMGNLHWVLQPDEEMSDFGHSTLVRMVKPWNQWMFIVLPKPGSGGEFAPTHEEYLKWVQRAIGDVSIPVEILNVSKWVINETVAEYYSDGNIFCLGDAVHRHPPLNGLGSNTCIQDAFNLAWKIAYVLSGQASPSLLDSYSPERQPVGKEIVTRANQGLRDHGPVFEALGMMGETLEERKRDHGQLSEATPEGAARRARLQAAIENTSHEFHGVGVEMNQRYESGAIYVHDESPRPSLPQDAVLEHEITTYPGSRLPHAWLNTRCPSKPFSTIDLAGHGAFCLLTGIGGEKWKDASKAAATELGVEIRSYSIGWKQDYEDVYSDWVRRREISESGCVLVRPDRFVAWRSAEMISSPEAKLLQVMKSVLGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPC6</accession>
    <name>A0A3D8RPC6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_06482</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPC6"/>
    <dbReference type="OrthoDB" id="6161812at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056125">
        <property type="entry name" value="DUF7708"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056681">
        <property type="entry name" value="DUF7779"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002182">
        <property type="entry name" value="NB-ARC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35205">
        <property type="entry name" value="NB-ARC AND TPR DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35205:SF1">
        <property type="entry name" value="ZU5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24809">
        <property type="entry name" value="DUF7708"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25000">
        <property type="entry name" value="DUF7779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00931">
        <property type="entry name" value="NB-ARC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7708" evidence="3">
        <location>
            <begin position="116"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="NB-ARC" evidence="2">
        <location>
            <begin position="295"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7779" evidence="4">
        <location>
            <begin position="521"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW75661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="985" mass="110830" checksum="F10096E0C19DCBA4" modified="2019-01-16" version="1">MASIRESTSSASPLYYTPSTTSSDSLRHNGLRTPGSAMRWQDARDKCLANLRLEERAIIRSFTSPEHLIADLQRREAEYSETISAQFISQIFPCISTIQDFSLLFLASMGPATVEVTFLWGILHLALKGLKTSQTTRTKTVEMLYQIRNELALFKRFSAGLNDDEEMRHAQSDMFSAMINFWSKAVGYLRKRSANVFSELLPQLDGDFKAAIIEMESSVERIHKIASFANRATEFELTSRNLDLLHISHLQESSSSNFPCYIIPFSNPYFYGRDKEMKAMAHHLDPPLEPYELRSYIVHGLGGVGKTALALAFAHRSRMSGLYDSIFWVKAKSHADLQNSFADIAASLKLSDSSQAITSDSSKLLVKNWLYTTRKRWLLIYDNVESWEVLEDFLPSSSGTIIITSRYSWIVHRVPGWRDGCALELETFTEKESFHLFTTLLKMYNPKASPASEKEAITTLLKKMNGHALGIEQIAAHIGYRRYSVKQFMAKYERRAAQIHSKKDHSSTSLHTVATVWEMHFENIQDTDSANLLALLSFLSPDDIPIQLFLPESELGISDFAPFCGDDTKLEDALDLLMHVALIKRHGENISLHPLVQAAYLESSYGRGQDIRQQAFHTVTVLVNDLFPKKSSSVALQERWAQCAVYLPHVLTLAAAYAQYSKTDHPLRSSSSLVELFKNSTHYQNDIGELHDCLKLLAIARDACTDKTGLPYSFLSNTTSCIYYELNDLPLCKKYQEETLAIRQAMLSSTDPGLGNIIMNIACRLTSEWRLDESLDLFQASKKIKLKDPNVSKQYLAHASASCGRVHMLKKEFELAEPLLTEARVILESLGPGGQFELAFIMFDIGKLGIGKGDVSAATKAFYAGLELSKNAYPMHILTGSYYFKLGVIAANARDFKGAREHLEKAFCIAEYQRIPGQMARIMRKQAMVLAEDPESNLNELAEGRSLRIRAAQIKGSLTMNSGLILDRGWTEDEVYDNLVVGHLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPN1</accession>
    <name>A0A3D8RPN1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Oligopeptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_06751</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPN1"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="140"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="271"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="532"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="581"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="613"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="684"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="722"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="760"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW75930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="815" mass="90652" checksum="DA15E885638B4B56" modified="2019-01-16" version="1">MAPRKERPFSIPAWKPIMAGIVVPDDDDEPILEEDRASTSSTDIKGGIQMNAYSKKDVSVMESEVSSVQSLVKLQSNDVEQLREKPLEANMETIALQALHTDDDFSLDPWTFRMFFLGIALSTFGSALATIFLFKPQSVSVSIIFLTVLSYVAGNAMSTLLPRTGTIGRWFNPQPFNSKEHLAIVVMSGSASGAAYATEVLATQKLYYNVVPNGFIAIMLLLSSQLLGYGMAGILRKSLVYPTKMIWPGILPLSSLIETLHRDKTEMKRKFNFFWIIFTIVAIWEWFPQYIMPALTGVSIFCLANRKSLVFTNIFGGTSGNEGLGLLSISFDWQYITTSSLFLPLITLTNAFIGFILCMILYISLYYGNVWRAQDFPFLAQQLFSQSSNSTSFAVYNQSAILDANNELDVKLLDSQGLPFFSATNASYLLTTNLSVTATVVHMLLYNFDNIRDAFSLPGTVAIKRAFSNPRFWRRSTETPEDEQNIEELDPHYQQMLKYDEVPNYWYALVGVTSLFIGLVCIYALKSTLPWYGFLIAVTLSFLATLFFGALAGVIGFSVPITSVIQLIGGYLHPGKPVANMYFVLFGANAQAQALGLVGNLKLGQYGKLSPKCTFTVQIIGTVLGAIINYGLMSSITTNQREILLSIQGTNIWSGQVIQSFNSNAIAFGALSKFMFSVGRTYEWIVLALPLGFLVPLPFYFLHRKFPGQGWDYIVTPVIVWYLGYLSVGINSSVTLFFVIGFFVQFYIRKRYPEWFLKYNYLLAAAISGGTELLVFVTTFAVQGASGKAVPFPPYWGNNFQKGNFDFCATNPALG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RQ08</accession>
    <name>A0A3D8RQ08_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_06906</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RQ08"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF3">
        <property type="entry name" value="HALOTOLERANCE PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="52"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="703"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="769"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="136"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="710"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="769"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW76085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="863" mass="96401" checksum="568B8F1679500404" modified="2019-01-16" version="1">MDRQADADAASKTTYRQERLPIARKPDVAARRPIALPNINHPPHDRQRVRRACECCRKKKIKCNGEEPCQRCIDYGVHCEYADYVAPIKPGDNGNIEQLENRIASMESLFRQFLERFENGNLGPTLPSAPFARVNAAAAEPPPAESSEVPNTLVGIESPGRDAALDGQSLECDEAGEFDIRNNSCNDNYDLDNEEPDSPSHSHCYADGFGELDTDTTGQLRYVGLGSTASVVDTCVGLRRHIYEGLEKKGIENEETIFRSPEATVTEAAIPTAQDMLSREMPSRPLICFLMDTFSADLYFLFPIIAKDDINAIYDTLQRDEVVDTSLAAIFFAVLAISALLIPPNHEIFAKVDARYQNMNCSASFYSTSLWFSNFPQRNMARRNGKLQDNVVALGLLSMYLAAIGSQAEAWIMIGNAIRHGQDLGLHRSPERLQLPQKERSRRRYLWWCLYVLERQLSTALGRPLSIDDADCDVEVPCKDTDPSHFEETTGFVSMIHLHKILGTILKTVNSVKNADSWREVTKYDELRKRIRDSNVALHTWAKEKVPQEIRTAQSGKNLIQKHVALSAFFCAVMLLHRIFMSNPHRPSPLADPQAQLQCAKAARDCIQGATDFLQCVPRSHFLVFHGQYVFVSAIVLLQCIRGSNDHQYIASDLCHVQSALDSLRALESSWVGAKKCRAIAEEYLEFTYHVLQAGRKGVCNFEHGTTRKPSSRRHSHTRPSAKRGLDYGESKSQSPTKSFKKRRSQNPRPHPSTETSIALACQSSGELGESLSRSRSNNISGTPPRLRGILKKPQVHVPAPPEMDGSYFDNVIDNGLGPMLTPQGVSFLPEGFFPNADFAFGSSDLSMLLPDFRNTWDGNEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RQ89</accession>
    <name>A0A3D8RQ89_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_06986</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RQ89"/>
    <dbReference type="OrthoDB" id="10310204at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW76165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="664" mass="75224" checksum="DE4252D4FB53250F" modified="2019-01-16" version="1">MAAEPSKTPDPEQDNAMDLLEDDHWVDKLSLIGSPRSFLSKDWSECALGPVKSWTKNLRLYTVKAFANSQPCSILWGTSKATVYNQYFALLAGNAHPQLMGNPPETHFPELWNLIKRVASKMEESKVPSDLEESQISIAQNQRIEETNLTAHVDPIVADSGEIEGLYLSFEEIADQKIKDRRAATLDHLVTQNVCLDGSLGKIMASISTSQPDVPLALLYGYDTSNVSRRCPFRLLDQTTNPANPTFEIIELDLFGLSILAKFLNEAGSAIATKPFEHMFGATEWQALGEPSQLVAILPLVGRDRIIGYLLAALNPRKSFDHHYRQFLESLRRYSSSVLYRELKHIELQRSLQLRERELIESRRQLDFLARHASVGVQHLSVDGTMLWANEQYYYLTGYPQLKEQQAKFSFLEVYLEDDQARIVDSWPDIAHDKNGTSIQLRQKRNFTPPSGVPEPVTIICTFFPCLKNGVKVIISYTVEKNSIHACAQLADSHHSQDRKVVTALVQEDGQRTTIEGIVRPYILPRERVPISRPMFVRELQAKEKRYPSRGTPLRNSHIFQRAGCITHIANHGVEALNYLRTTTCWYEHDANSNPLDIIIIGRGMQIIDGKACSREIRAYHASGKIIRHVPIIAIWPTTFSHIEEPPNDNVVRFSDRFGSLVRC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RV18</accession>
    <name>A0A3D8RV18_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sugar phosphate transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_05771</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPT transporter family. SLC35D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW77919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RV18"/>
    <dbReference type="OrthoDB" id="18894at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="363"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="483"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="507"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="545"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="583"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="613"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="641"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="10">
        <location>
            <begin position="335"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="43"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="676"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="124"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="222"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="709"/>
            <end position="718"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW77919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="735" mass="79941" checksum="87995833275CA2D7" modified="2019-01-16" version="1">MVDVCWFPLFHPCSASPLVRLAAAHGPSHHPRPLGHSPLSIRASAAAATATATEPRKSTSHLPVILSSSSPPSPINGTRPSPPVSRPAPANWKIMDGHSLPLPPPTASASSSSSTTAPDHHASRSPSATAPAPKHITNSISTSTTTPGSSSASHFPHPGLPRLPTVSDLLARESSEHDEWTPDAADAVESLSSHPQDPGMEPTQPSGHRRRRSSLMNSIDGGKGHARDPSKRTNLSPRHLPGGIQEEGRPLNSARGSDEDSKSTSEDLELDDLSEEDGLQDDEETGLTAKDKSKRRRRRRRNTLLDQRVARDVKVTAEEKKAADLTVLKNGIINGFLIGLWYLFSLSISIYNKWMFSPNHLDFHFPLFTTCLHMLVQFSLASAVLYFLPHFRPRYDSLSNPHNTQAADEDLAQHEAEQKKPLMTRMFYLTRIGPCGLATGLDIGLGNMSLKFITLTFYTMCKSSSLAFVLLFAFLFRLESISWRLCAIIATMTAGVIMMVAGEVDFVPLGFVLIMSAAFFSGFRWALTQILLLRNPATSNPFSSLFYLTPIMFVTLFIIAIPVEGFPALFEGLSLLMEKKGPILGPLLLLFPGTLAFCMTSAEFALLQRTSVVTLSIAGIFKEVVTISAASIVFHDMLTKINISGLIVTITAIAAYNYIKIRKMREDAQIELVKQHHPNLNGGGSGSGSDADGEDDYDEGLYVTADGDLLPRPDRTEDVPVGGHGNESSRKDNTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWH7</accession>
    <name>A0A3D8RWH7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_06249</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an important role in cellulose degradation. Shows hydrolytic activity against several glycosidic compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWH7"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080079">
        <property type="term" value="F:cellobiose glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000011">
        <property type="entry name" value="Cytosolic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033132">
        <property type="entry name" value="GH_1_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF36">
        <property type="entry name" value="LP05116P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00653">
        <property type="entry name" value="GLYCOSYL_HYDROL_F1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW78397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="478" mass="53557" checksum="B76B478516FA8F09" modified="2019-01-16" version="1">MPTPVLPKDFQWGFATASYQIEGAPEADGRGPSIWDTFCKIPGKIADGSSGAVACDSYNRTAEDIELLKSTGARAYRFSIAWSRIIPIGGRADPVNEKGIAFYKKFVDDLLAVGITPFVTLFHWDLPDGLDKRYGGLLNKEEFVQDYAHYARTLFAAMPKVKHWITFNEPWCSSILGYNTGLFAPGHTSDRSKSPVGDSSREAWIVGHNLLIAHGAAVKIYREEFKSKDGGEIGITLNGDATYPWDPNDPLDVEAAERKLEFSISWFADPVYFGRYPESMIKQLGDRLPTFTPEEVALVKGSNDFYGMNHYTANYVKHKTGTADPADFVGHLDMFFENKAGECIGPETQSVWLRPNPNGFYELLKWISKRYGGPKIYVTENGTSLKGENDLPREKILDDEFRAEYFRGYVGALADAVKEGVDVRGYLAWSLMDNFEWAEGYETRFGVTFVDYEGGQKRYPKKSAQTIGPIFEGLIKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S239</accession>
    <name>A0A3D8S239_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_05024</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S239"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF115">
        <property type="entry name" value="DIHYDRODIOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G07520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="8"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="149"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW80326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="382" mass="41445" checksum="F2DCACE2BAF5B9E5" modified="2019-01-16" version="1">MASPKTIRWGILATGGIAATFTKDLLVDPTTRGVSNIKHIVVAAASSSSKSRAESFLRECDCDASTAAYGSYEELVRDPNIDIVYIATPHSHHYQNAMLALEAGKHILCEKAFTINAEQAKKLVAKAKEKNVLLMEAVWTRYFPLSIYVRETIQNGVIGPVSRVISDNSVSMNPTVKFADGKHRMVNPDLGGGALLDLGIYSLTWIFQTAYHTQAPGLRQPPEVLAAVKKYRGSAADETTTVVLNFPRPESAGGDIHAIATTSLSLAGPGSSIPAVRIQGTKGEIQVFGPAPRPNRTKLMLADGTIEEKAWSQPGPEGQGQGQGMFWEADEAASAVLEGRKEGKYLGWEETITIMEVMDEIRRQGDLKYPDKIETTEYPTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S295</accession>
    <name>A0A3D8S295_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_05115</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S295"/>
    <dbReference type="OrthoDB" id="166134at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15761">
        <property type="entry name" value="FYVE1_Vac1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15737">
        <property type="entry name" value="FYVE2_Vac1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.20">
        <property type="entry name" value="Rabenosyn, Rab binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052727">
        <property type="entry name" value="Rab4/Rab5_effector"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021565">
        <property type="entry name" value="Rbsn_Rab-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036531">
        <property type="entry name" value="Rbsn_Rab-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510">
        <property type="entry name" value="FYVE-FINGER-CONTAINING RAB5 EFFECTOR PROTEIN RABENOSYN-5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13510:SF44">
        <property type="entry name" value="RABENOSYN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11464">
        <property type="entry name" value="Rbsn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140125">
        <property type="entry name" value="Rabenosyn-5 Rab-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="8">
        <location>
            <begin position="200"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="FYVE-type" evidence="8">
        <location>
            <begin position="338"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="155"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW80417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="648" mass="71867" checksum="6CE17DA5B87F3A02" modified="2019-01-16" version="1">MSARRLGGGRILGSGKSLAPPAPPAHQRSSSLVSPSESTLSLESHTSVSPLATSPLPDNIQDLASRVSLENGAVGAVAAASSKLVCPICNEEMMTLLQLNRHLDDNHQELPEVEQDEVKNWFDKQVVKAKKFQPLAVINQKLKGLDVFESNDVSTSSAPPSLISGNRVSTPEYRPDPDEVVTRAHWQKAGYSDLCTEPACGKRLGAVNGSVNCRKCGRLFCEDHTMYQMKLSRSAQHEPVRGFWCRVCETCFKSREGYNDHNGLVKDHTSDFLAMRRKTVDKQYLEISRLEKRLTKLTQLLANPPEDLTGSGGSLMSLSGQKTQRKVLEQSIVTWEDDAKVLKCPFCRQEFGSWSFRRHHCRLCGRVVCADPRTGCSSEVGLNVAAKKASGDLSLDIRMCRDCKATVFSKKDFAEEVMHKPPDQRSYENLVQFEKGIRLLLPNFQRLLFALQDPIKPPSQAQLAEASKVRKRLIDSFGKYDLAAKRIRDLPTKSPTQMKLQRSIYQQSSNFLHIHMLPLKTLPKILKHATPHGATSLRNNITSNGNGGALASIRINDLDAASQISSSSAVSAMEAEEKELRERLIVLEEQKFFVSEMIADANKRRKFDEVSSLSSNVADLSKEIDQVNGMLSQLDFAGAYAQNGVMGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2X6</accession>
    <name>A0A3D8S2X6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinase</fullName>
            <ecNumber evidence="4">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_05149</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2X6"/>
    <dbReference type="OrthoDB" id="338650at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000824">
        <property type="term" value="F:inositol-1,4,5,6-tetrakisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF103">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE MULTIKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="271"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="280"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW80451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="339" mass="37290" checksum="01204F71C18639B6" modified="2019-01-16" version="1">MAKPLPAPADLVDYNYAVAGHDGVLCDADGELFIKPCTLPEVAFYEASIQDHPDFAEYMPTFLGTLELSEHQNVSIEEQGAALIAKRSIPEPVVPTKTGKRIATNTAVVLENAAHGFVHPNILDVKLGVRLWADDAHQDKKKRFDLVTLETTHKDLGFRIAGMRVWQGEGAVGADIDQDGYRIYNKDYGRFSVNTSNVNEAFRNFIFAESAGIDEELGRLVAQAFLADLTRIQEVLEGQESRMFSASLLFVFEGDGAALRCAMEDASKPAINGNGHHVVDEDEEEADEDDEEEETLPKIYTLKVIDFAHAQWTPGMGPDENALTGVRSVARILRDLGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2Z3</accession>
    <name>A0A3D8S2Z3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Basic proline-rich protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_05336</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2Z3"/>
    <dbReference type="OrthoDB" id="3366093at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005034">
        <property type="term" value="F:osmosensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006972">
        <property type="term" value="P:hyperosmotic response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007232">
        <property type="term" value="P:osmosensory signaling pathway via Sho1 osmosensor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001402">
        <property type="term" value="P:signal transduction involved in filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039295">
        <property type="entry name" value="MSB2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35778">
        <property type="entry name" value="SIGNALING MUCIN HKR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35778:SF1">
        <property type="entry name" value="SIGNALING MUCIN HKR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017723588" description="Basic proline-rich protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="989"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="627"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="678"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="764"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="952"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1020"/>
            <end position="1092"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="564"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="649"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="952"/>
            <end position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW80638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1092" mass="105001" checksum="FB4F86C3297E0997" modified="2019-01-16" version="1">MHTPSLAIASVALFSTFAAATPNQPKFYFPRQIKRFTNSSITSQSSVLPSSTPDLTSSDSTTTKRSSSSLTDLFSQLTSSDGLTSAGSTGSAPVLIPTSPTSPSDSSTVVSASTSTDTGVTTVVNTATVLVDGTSTSTLDSSTETSSAVASSSAGLVSVLSSVLSPLVGTGSSSVVIVSPTASVELTTSQPAVASAVGTGSSSAVVVSPTASAESTTSQPAASSAVGTGSSSVVVVSPTASAESSTSQSAASSAVGTGSSSVIVVSPTASTSSEVAASSAVGTGSSSAIVVLPTSSLVSVLSSVLGTGSSSAVVVLPTPTSSSAVVSSVASAGTGSASIVVVQPTTSQTSEVKSSSVASLASNSGAITFGPSGVVTSSSSSASVETSSPVAVSSEVARSSGVSFTGSASVTDPASSSAPTTTSALIPALLSSVVSDLSSVVATSSAAAGITGPASTGAAASSSTPVSGGSSSALLPSLVSSIVSDVSSVVGISSVASATSSIAAGITGPPSAGVAVSSSTPVAGASSAVASSGSSDLLSSLVGSLTDVLPSASSAASITNSGISGPASTGATATSGSAASTTASPDLVSSLLSSLSSEIKGSSTIASAGSASTTGLGSIISSIFGSSTATSDPGSATETASPSIPGAETNSSTVSTTPATTVLPTSIAGDNTTAISTAPSSSLTSSVFTSTSAPSSQSTGSSSNGTDSVTSSASLTTLPTPSSNGTSVPIIISASSASSVATSAQSVSVTSLASGSFSSVPAPLTTSSSQTPVFTVQPTGSDSATSLWLPTTIIAQSSSGTLSTAGSTATALPTDLPKVISPASGTPSAPPDSTLIQIGFKYALNYPFVVDHTMSSAQIIEYLPEGVADGLRLSMDQITMHSLIPYDTRKQLGFVTTLALLYIPTSMVNTLQLAIKTPVSEIYKLPSTSVSTLMTYINPAIPILPGSTLSGTDASGTGAAPSATSTAASNGNGVFGSTTQNTSSSVKGATAGIALGAIGGAAAYGVAMFFVARRYKKKKQAHRRSSSILNPAEMRQSGSPALAGGALMSGGRMSPYDRDSRGSRGSGRSNGNSARTQQISAPMMAENSLGWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S429</accession>
    <name>A0A3D8S429_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_05628</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S429"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW80930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="88" mass="9605" checksum="990D4FACF77561B5" modified="2019-01-16" version="1">MNSSRQDYSVQGKDLSPVILQTIEPAEEVLLAQPVRNDSDSPSIRVPNVFSSMPVTDAVLISPFPIIGESARENYRPCQIIAASYARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S9I4</accession>
    <name>A0A3D8S9I4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Saccharopine dehydrogenase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_04424</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW82933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S9I4"/>
    <dbReference type="OrthoDB" id="10059875at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004753">
        <property type="term" value="F:saccharopine dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000008">
        <property type="entry name" value="Alpha-aminoadipic semialdehyde synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000072">
        <property type="entry name" value="Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1870.10">
        <property type="entry name" value="Domain 3, Saccharopine reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051168">
        <property type="entry name" value="AASS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032095">
        <property type="entry name" value="Sacchrp_dh-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005097">
        <property type="entry name" value="Sacchrp_dh_NADP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133:SF22">
        <property type="entry name" value="ALPHA-AMINOADIPIC SEMIALDEHYDE SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11133">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16653">
        <property type="entry name" value="Sacchrp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03435">
        <property type="entry name" value="Sacchrp_dh_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="3" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Saccharopine dehydrogenase NADP binding" evidence="4">
        <location>
            <begin position="6"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Saccharopine dehydrogenase-like C-terminal" evidence="5">
        <location>
            <begin position="124"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW82933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="450" mass="49275" checksum="AC7437196EE19D4B" modified="2019-01-16" version="1">MDTKNVLLLGAGLMAKPTLNVFEEASIPVTVACRTLSRAKELCKDTKHANAISVDVNDQQELDHAVAKSNLVVCLTPYIYNATIIKSAIRNKKNVVTTSYISPAIQALEPEIKAAGIVVLNECGLDPGVDHLYACKVIQEVHTKGGKIKSFISNCGGLPAPEASDNPFGLKFSWSPRGVLLASQNPAKRLWNGQVQEIAGGIDLMDTVEPYFIYPGFSFVAYPNRDSSVFSERYQIPEAETVSRGTLRYPGCTEIFKTLGAVGMFSLQPLQILDGTSKPPSWKELTQEILSAPTTSETQLIAEVDSRTQFKSVCERNHVISGLRWLGIFSDKPVDVRKTPLDTLCALLQEKLSFAPDERDMVILQHKFEIEHKDGSQETRTSTLLEYGDPQGFSAMARLVGTACGVASTLVLDGTITMPGVCAPLTADINEPFMQRLLKYNIKCVEKTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S9P9</accession>
    <name>A0A3D8S9P9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial ATP synthase epsilon chain domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ATPase epsilon family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S9P9"/>
    <dbReference type="OrthoDB" id="269124at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12153">
        <property type="entry name" value="F1-ATPase_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1620.20:FF:000003">
        <property type="entry name" value="Mitochondrial ATP synthase epsilon chain domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.20">
        <property type="entry name" value="ATP synthase, F1 complex, epsilon subunit superfamily, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006721">
        <property type="entry name" value="ATP_synth_F1_esu_mt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036742">
        <property type="entry name" value="ATP_synth_F1_esu_sf_mt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12448">
        <property type="entry name" value="ATP SYNTHASE EPSILON CHAIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12448:SF0">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT EPSILON, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04627">
        <property type="entry name" value="ATP-synt_Eps"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48690">
        <property type="entry name" value="Epsilon subunit of mitochondrial F1F0-ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW83089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="75" mass="8337" checksum="0952DAD62C71448F" modified="2019-01-16" version="1">MTFAWKASGITYNKYLSVAARVVRRSLKDDKRLAAERRGEMELRMAKWSNGKQGEIKNVADVNAAAIAEHNAPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SA14</accession>
    <name>A0A3D8SA14_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_04435</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the germin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW82944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SA14"/>
    <dbReference type="OrthoDB" id="1921208at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02241">
        <property type="entry name" value="cupin_OxOx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001929">
        <property type="entry name" value="Germin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019780">
        <property type="entry name" value="Germin_Mn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31238">
        <property type="entry name" value="GERMIN-LIKE PROTEIN SUBFAMILY 3 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00325">
        <property type="entry name" value="GERMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00725">
        <property type="entry name" value="GERMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017735120" description="Cupin type-1 domain-containing protein" evidence="6">
        <location>
            <begin position="24"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="7">
        <location>
            <begin position="141"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW82944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="344" mass="35442" checksum="BE77B9BD17570C1B" modified="2019-01-16" version="1">MGFTLRVFLLLAISVALLALVEAMPVQDFPGINARSQTAASLVGNQDAAKKAGTNAKSTAAQSSTVVAANAKTTAATGATATTDVDPNFDLAAATSAEKAAAASATVLAASANELKVSQLMTASSSVQKLDILSDDTDWKFDFNTEPAGANGLGGTIVTANLASFPVTQMTGSSMAIGVMGACGFATPHSHPRANELNLVTQGQLISTMTLENGVRVINQTIGFQQMTVFPQGSMHMEYNPGCTNATFVAAFTSADAGVQQTMTAFTNFGDQVVQATMGGALTVDGKDIDAFKTAIPINVALGVESCLQACGLKKRSLMETREVLKRGLQARTVATEKAQAFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SA36</accession>
    <name>A0A3D8SA36_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04621</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SA36"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW83130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="85" mass="9197" checksum="A8A987F811239E84" modified="2019-01-16" version="1">MADQETSFVVTAAEVFRAAMKLGKGNGQRMRKLASARITAAAGRSRDDRRAKVSPSQVSLSDAEREVEIRELIQAQSAAHVELAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SA65</accession>
    <name>A0A3D8SA65_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Clustered mitochondria protein homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Protein TIF31 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">CLU1</name>
        <name evidence="4" type="synonym">TIF31</name>
        <name evidence="7" type="ORF">BP5796_04651</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">May associate with the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CLU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1414216at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048312">
        <property type="term" value="P:intracellular distribution of mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd15466">
        <property type="entry name" value="CLU-central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000293">
        <property type="entry name" value="Clustered mitochondria protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000532">
        <property type="entry name" value="Clustered mitochondria protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2280.10:FF:000002">
        <property type="entry name" value="Clustered mitochondria protein homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2280.10">
        <property type="entry name" value="Hypothetical protein (hspc210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03013">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028275">
        <property type="entry name" value="CLU_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027523">
        <property type="entry name" value="CLU_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023231">
        <property type="entry name" value="GSKIP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601:SF6">
        <property type="entry name" value="CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12601">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13236">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15044">
        <property type="entry name" value="CLU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12807">
        <property type="entry name" value="eIF3_p135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103107">
        <property type="entry name" value="Hypothetical protein c14orf129, hspc210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Clu" evidence="6">
        <location>
            <begin position="335"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="634"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="916"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1261"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1270"/>
            <end position="1287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW83160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1287" mass="142220" checksum="7296D4255DD51FFD" modified="2019-01-16" version="1">MPEMDDVHAATSEIPAESTNGTTLTEEDGAVTAGASHEAEEAAEQGESFFSLNVILPHEPHKMHIMVSSQEQIHEVRQSIIELPGTFQYSCFHLEHNGEAINDFSQISDIKDLAADSELHLVEDPYTEKEARIHIVRVRELIGAAGDRTDTLQGILSGVSLHDFVSQGPSDAADASTPVAHPLAGYDLQAPGVLSTLLPQAQEIAPKTVKSISVSPWNPPPYHLRQKGHLLYIQVTTNEGEQYQITSHVSGFYVNKSSNSKFDPFPRAAPKSHAAHSLLKLISDLSGSFESTFKNLQEFNNQKEPLSTFQITNAIPSSPWIVPSSSSPLTVHQSDLTRTQESYLISGIENTETLRDWNEEFQTTRELPKETVQDRVFRERLTSKLFADYTDAAARGAVLVARGEVAPLNPTEGRDAQIFVYNNVFFSFGADGVGTFASEGGDEAARIATGKDVMGVRIVNQLDIDGLFTPGTVVIDYLGKRLVGQSIVPGIFKQRDPGENQIDYGGVDGKDVVAADEKFVPVFEKLSKALKVKKHSVWDKSGKKFELEGSVETKGLLGTDGRKYVLDLYRITPFDICWMEENGTAVSSQEATDGASNTAYPHRMTVLRPELVENYWKLKMREWVNEELKLRSKAKKDAITASTGDTAAPKEEGTEEDSSNAEKPTETENIDDERIDISKFSFCLNPDAFSGQEPQTEAEKEEWASDEQQVRLASEYLRTKVLPELVSDLKDGDIGFPMDGKSLSGMLHKRGINIRYLGKLATLAEGKKLDALRILSIQEMISRAFKHVAARYLRYLPIPLTSACFAHLLNCLLGTGFNPKPKAEIDEAMAALYSQADLTFQDMTPESLKQEIETQILKRYRYTIADNWVTEIKSVQLLREVSIKLGLQLEIKDWRFTAQNTNADVAPVNNGTISKDKVLSGQSTSSKKKKKARDGSPASITSVTAASPTTFSPDDILNIVPVIKEASPKSSLAEEALEAGRISILQGQKKLGQELLLESLSLHEQIYGILHPEVARVYNSLSMMYYQLEEKEAAVELARKSVIVSERTLGVDNAETLQSYLNLGLFCHSSGDTKQALGYMRHALELWKIVYGPSHPDSITTINNAAVMLQFLKDYHESRLWFEASLEVCEKVYGKQSINAATLLFQLAQALALDHDPKGAVNRMRESYNIFLAELGADDKNTKEAESWLEQLTTNAVSIAKHAKDVQQRRLKAGLRVSPRVTLGQTHPQLQVGQSAESVVGRNQPGAGGLDSRTIDELVKFIEGTDQKTTPKKRTGRTNPKRRGGKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAX5</accession>
    <name>A0A3D8SAX5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative 60s ribosomal protein l16 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_04792</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAX5"/>
    <dbReference type="OrthoDB" id="1882297at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3250:FF:000001">
        <property type="entry name" value="60S ribosomal protein L13a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023563">
        <property type="entry name" value="Ribosomal_uL13_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_uL13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00783">
        <property type="entry name" value="RIBOSOMAL_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW83301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="184" mass="20924" checksum="9708C43EA2076CB6" modified="2019-01-16" version="1">MSTFEPVITIDGKGHLLGRLASTVAKQLLNGQKIVVVRTEALNISGEFFRAKRPFHFRAPSRIFYKTVRGMIPHKTARGAAAMERLKVFEGVPPPYDKVKRVVVPQALRVLRLKPGRKYCTVGRLSHEVGWKYQDVVARLEERRKVKGAAYYARKKAARRQLSDAQKSAKVDEKTKKQLAEYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SB32</accession>
    <name>A0A3D8SB32_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS transporter-20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_05007</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SB32"/>
    <dbReference type="OrthoDB" id="440553at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015137">
        <property type="term" value="F:citrate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000172">
        <property type="entry name" value="MFS multidrug resistance transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000009">
        <property type="entry name" value="MFS multidrug transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF26">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="520"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="548"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="589"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="616"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="182"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW83516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="650" mass="71076" checksum="F58E641789EB89C4" modified="2019-01-16" version="1">MDRQYPPRSTAAGRASRRLSTMEGWRDVRTGVYSAAGNGLRALSIQQQFDPERYDNEERVAATRMSKRVSTLYASGAYANGAYGNYGNYPNYPNDGPRYEYRESTPADVVKQMESVNVTEQYPPLPPPPAPPLNPFHDAYAPQNPFGDAYAVQNPPLQEKLPPAPLPEEPYHVFNPKQKWTLVIIIGVAGLFSGLSSNIFFPSLDAISKDLNVSLNTVSLTITSYLIIQGISPVFWGSLADTLGRRPIYIASFSVYIIANIALSFSPNFAILLIFRGIQAAGSASTVSIGNGVIQDICPPSERGAFISFYQAIRNFSIAVGPVIGGILANFFGFRSIFVFLLILSALTLIVIIVFLPETLRSIAGNGSLRLSGIHQPIIRRVQKEPAYMEDPDENYQRKKVTFMTFIEPLKLLRRKDVLFNLLFGGVVYTIWSMVTSSTTGLFKDQFKLNELLLGLCFLPNGLGTIVGSTIIGKLMTNDFKAAEVTYRQVNNLPADYKLPSKNLPANFPIEHARLRHLPWITAIFVLATAIYGFTLAIPAVVSLTGWIAVPLFLQFLIAATSNAIFALNQTLVSDLCPGKGASSTAINNLVRCGFGAVGVAFIETMISSIGSGPAFLGLAFIVIAVTPLVVVNWYNGPGWRAERANTSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SCG0</accession>
    <name>A0A3D8SCG0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">G-protein coupled receptors family 2 profile 2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_04949</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SCG0"/>
    <dbReference type="OrthoDB" id="18453at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007166">
        <property type="term" value="P:cell surface receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022343">
        <property type="entry name" value="GCR1-cAMP_receptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017981">
        <property type="entry name" value="GPCR_2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF22">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05462">
        <property type="entry name" value="Dicty_CAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02001">
        <property type="entry name" value="GCR1CAMPR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50261">
        <property type="entry name" value="G_PROTEIN_RECEP_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="26"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="G-protein coupled receptors family 2 profile 2" evidence="7">
        <location>
            <begin position="20"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="248"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="438"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="264"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="454"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW83458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="466" mass="52249" checksum="E6629738FEACF7B8" modified="2019-01-16" version="1">MNLFKRTATDEISEAQLEALVIVERVGSSLSLIGCIFIIVSFLMSKAFHKPINRLVFYASIGNIMSNIATIVARASLGSLSSFLCQFQGFLIQMFMPADAYWTLAMACNVYLTFYFKFDAPRLRRMEPVYIACCYGIPFVPAFIYIWIKTSENGRFYGNATLWCWVANNWDIWRILTFYGPVWIVIFITVAIYLRAGVEIYTRRKQLQYFSQSALETLPHVENPFTTMKTTEVSVTSEAIDTSDTIDLHQLGRPHKPNPGGYSVSISTSQAMGDQSPPSFTEKLPPSSIQLPEIHPLSLSPIQPTTSSAAQPPFIPPEIPDRSHAHPAKRRAAVEANSAAWGYTKVALLFFTAMLVTWIPSSANRLYSLVHPGQVSIPLEFASALVLPLQGFWNAVIYITTSRQACKAFMGHLFSRQRVTTRPVTQLSNLFNHEVKSPRRLSSPLHSLDGESMTELTSRPTASHQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SH63</accession>
    <name>A0A3D8SH63_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial</fullName>
            <ecNumber evidence="4">2.1.1.201</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ubiquinone biosynthesis methyltransferase COQ5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="primary">COQ5</name>
        <name evidence="6" type="ORF">BP5796_03971</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-methionine = a 5-methoxy-2-methyl-3-(all-trans-polyprenyl)benzene-1,4-diol + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28286"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="Rhea" id="RHEA-COMP:10859"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="ChEBI" id="CHEBI:84167"/>
            <dbReference type="EC" id="2.1.1.201"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion inner membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
            <orientation evidence="4">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.201" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SH63"/>
    <dbReference type="OrthoDB" id="6329284at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008425">
        <property type="term" value="F:2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000133">
        <property type="entry name" value="2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01813">
        <property type="entry name" value="MenG_UbiE_methyltr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01184">
        <property type="entry name" value="UBIE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 4 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="4" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="169"/>
            <end position="170"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW85646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="305" mass="33652" checksum="2E0D35B38FAA18E1" modified="2019-01-16" version="1">MATRSVLRPLLRSRQLPSFSAQRSLSTSLRRADSPSQPSNHERTTHFGFETVPEAEKEARVAGVFSNVAASYDTMNDFMSLGIHRLWKDHFVRSINPGSPNQAWKMLDIAGGTGDIAFRLLDHATNINSSPASTITISDINPAMLAEGKKRSLETAYANSPRLDFLVANAENLHTIPSNSIDLYTVAFGIRNFTDKDKALREAYRVLKPGGVFACLEFSGVTNPILDAVYKQWSFGAIPMIGQLVAGDRASYQYLVESIEKFPKQEEFKNMIQNAGFVVPGKGWEDLTFGIAAIHKGIKPIETKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHX2</accession>
    <name>A0A3D8SHX2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">galacturonan 1,4-alpha-galacturonidase</fullName>
            <ecNumber evidence="14">3.2.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BP5796_04264</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="14"/>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHX2"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF12">
        <property type="entry name" value="EXO-POLYGALACTURONASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10 16" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017749891" description="galacturonan 1,4-alpha-galacturonidase" evidence="17">
        <location>
            <begin position="16"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00037312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDW85939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="438" mass="47275" checksum="3719DA4F49E7ED51" modified="2019-01-16" version="1">MRFLSLTLLASAVAGFVVNQGSTCTLYPESLTHGGLPVDDVPSIHEAFNICGINGTVIFSNGTFNIATVLNTTNLLNVDVILRGVLQFTDNIPYWRSHSWSVIFQNQVTSWLFGGTNVTLRGDGGWIDGHGQSWYTFSANTANLPGRPITITVYNSTNVLIDSLSIIQPQFWAFFVWKSQNVSLTNYYTNATSNNAKFSTFNTDGFDSWNSDTILIENATIITNDDCVAAKGNTTNLYAKNITCYGSTGMTIGSIGQYPATPDYVFNVTFEDVRCIGGLDCAYVKTWQSAALDVTTNGDAGGGGGGLVKNVTFRNFEVQDVGLPIQVTQCIYATASGQGCNTSNLALEDISWVNFTGTSKYNIAASMYCASNHPCPGIMFSDVNINSVNATEGLALYNTTLQTEVYQCDNIIGQNTSGIPCNHVAPAFFSQAVTKNVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SI59</accession>
    <name>A0A3D8SI59_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glycerol kinase</fullName>
            <ecNumber evidence="3">2.7.1.30</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">ATP:glycerol 3-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_04186</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the FGGY kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.30" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SI59"/>
    <dbReference type="OrthoDB" id="5422795at2759"/>
    <dbReference type="UniPathway" id="UPA00618">
        <property type="reaction ID" value="UER00672"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004370">
        <property type="term" value="F:glycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019563">
        <property type="term" value="P:glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046167">
        <property type="term" value="P:glycerol-3-phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07792">
        <property type="entry name" value="ASKHA_NBD_FGGY_GK1-3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000086">
        <property type="entry name" value="Glycerol kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000085">
        <property type="entry name" value="Glycerol kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000577">
        <property type="entry name" value="Carb_kinase_FGGY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018483">
        <property type="entry name" value="Carb_kinase_FGGY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018485">
        <property type="entry name" value="FGGY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018484">
        <property type="entry name" value="FGGY_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042018">
        <property type="entry name" value="GK1-3_metazoan-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005999">
        <property type="entry name" value="Glycerol_kin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01311">
        <property type="entry name" value="glycerol_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000756">
        <property type="entry name" value="PRK00047.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196:SF69">
        <property type="entry name" value="GLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10196">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02782">
        <property type="entry name" value="FGGY_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00370">
        <property type="entry name" value="FGGY_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000538">
        <property type="entry name" value="GlpK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00933">
        <property type="entry name" value="FGGY_KINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00445">
        <property type="entry name" value="FGGY_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 10 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase FGGY N-terminal" evidence="11">
        <location>
            <begin position="59"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="Carbohydrate kinase FGGY C-terminal" evidence="12">
        <location>
            <begin position="323"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW85861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="571" mass="62907" checksum="D01AAAFF8F8CE107" modified="2019-01-16" version="1">MLSANSLTANPHLEDLKLVDVDPEPTSLHVESITPPAVEETEPKELTYATTEKKDKWFIGSIDQGTTSSRFLIFNGEGTPVAGHQIEFENIYPESGWHEHDPAELVSSVEQCIEQATAKFLDLGHEKADIKAIGITNQRETTICWDTNTGEPLYNAIVWPDTRTKDLVRELKDRKGSEDLLQMCGLPLSTYPSSVKLLWLCRNVEAIRLAYEEGRLSFGTVDTWLIYKLNGGKEANVHVTDTTNASRTMFMNIHTLQYDDTLLDFFQLDRKNVTLPKIVPSSDKDAFGKLASGALQGIRITGCLGDQSSALVGQCGFKPGQAKNTYGTGCFLLYNVGDKPVISKYGLLATVAYDFGNGRPAAYALEGSIAVAGSGVKFLMNNMGFIRDSSKITELAESVKDNGGVVFVTAFSGLFAPYWIDDAKGTMFGMTQHTQRGHIARATLEATCYQTKAILDAMEKDSGHALEGLAVDGGMSNSDMTMQTQADIIGIPVDRPVMRETTALGAAIAAGFAVGIWKEFDELKNINREDRKIFSPGPDKKKYRQMFRKWEQAVEMSRGWVRETEALDAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SLV1</accession>
    <name>A0A3D8SLV1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-rRNA-processing protein RIX1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_02999</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RIX1/PELP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SLV1"/>
    <dbReference type="OrthoDB" id="20900at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012583">
        <property type="entry name" value="RIX1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34105:SF1">
        <property type="entry name" value="PROLINE-, GLUTAMIC ACID- AND LEUCINE-RICH PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08167">
        <property type="entry name" value="RIX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-rRNA-processing protein RIX1 N-terminal" evidence="6">
        <location>
            <begin position="7"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="647"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="700"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="472"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="649"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW87305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="744" mass="80460" checksum="6A69689EBD0A1BD1" modified="2019-01-16" version="1">MSLPPELRLLCLQLSSTPTEQLPRLTPVLLRHVLRCQGPLSSSGNNTAKADASASSVLVHKLKTQLSTLLNGRSTEGRFAAVVLIKGVVEVGGWEVLRGSEPWIRGLLSILKKPDPEATKELCVVTLTKIYCMTHQYQTLVRELTTPTLPAFITECVALLPARSSGKALDTSQSLIEAIFRSFAVLIPRHSTIFRSFAGVIRSRAKPFLAPTFSDGYFVSSSVVESARCASVALHHTVAKNAGGDEWARFVREYVKHVHITADQVFRAVIEDWESTTGYISSSVDVNQELFGGSELDDPSQFPRWDGIDAGVQRLIGLLGLLEEYLKSETPAQVSVPLGLLLDMTTRMLSIIIPTTTPTGTEQGGSRLHPAIGREERDGLWSGLPQVYVAALGLVSAMLDRFESKFMSLASGSLDQLLWMFPSGRGYPEFRAAAYSLMTNLLPLIGGGLSRPTVVKMAPVMRLCCKDLQPDSQSSSNNNNGSESSGGKPNIAGMNMNADALLQNGVGNASQLIQDPALVAAASTLLPVLLSHVPQQNIDLSLRALLDRTAILSQNKEAMLSSIVHPFIGKNGNGIPSILPHFARAFSHDNTVEVLLRPRMPVVPSSKVVEHLDETAEFREEEEEAVMDTSDKPVHQELPMVFETERNAENNTTTDTTTGTTTSKNMVENHSWFGGASSGVATTITPAGSAFTGVTEMVEPVQASEKVPASGPNEDVKMGEDSESDSDDESVHLTMQLDEMSDSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SN49</accession>
    <name>A0A3D8SN49_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_02912</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="8">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
            <location evidence="1">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SN49"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF19">
        <property type="entry name" value="SERINE PROTEASE AORO, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0106">Calcium</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase S53" evidence="9">
        <location>
            <begin position="268"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="343"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="552"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="593"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="594"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="612"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="614"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW87218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="635" mass="69403" checksum="BE97C5EB0781DF76" modified="2019-01-16" version="1">MLALPLLDEYFGLSIIFPAEIPLVFKMKGLRLLVAISIFASVRAAPYSPYVVHAKRDTSLASNWIESTEKVHSNAIIPLAVALAQQNLENGYDFLMDVSDPTSQNYGKHWSLEKITETFAATDEAIEDVVSWLSGNGISENRTILSTSKTWIRVNVTIAEAETLLKTEYKLYNHIHTRKCSLAVEEYSVPAAIKRHIDFISPTVLSSSTLKRMNPKRHGPVESDPVFANFPNPPTPEKPNNAALQTGGSKVVATNPWAWDLSYCAYEFITPACIRKLYNVPNGTLDLSSYAVVEYYTEYYNQTDLSTYLYNMNPVAPSDTFPTMYVAPDAAYPTNFTGDDDVEGNLDIQLATAIVYPQTMSYYQLNDDDVFLDAVDASYCQLTGSTSGCGVMPLTDVVSTSWGYSEDQIDDERIRECNEYMKLGLNGKTLLWSSGDDGVGCTATNAFQATWPSVCPYVTSVGATQIPKGGSVSDGEVATFGFSSGGGFSSYYPAPAYQAATIARYWQHYNPNISAVYFNTSITNRGYPDVAANGAYAAIVVGGEWQLWGGTSQSCPTFGGIITLINEQRLAAGKSTVGFINPVIYANPNAMNDITSGSNPGCLDYGFSAVKGWDPVTGLGTPDYKKLLNVWMRLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SNH0</accession>
    <name>A0A3D8SNH0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_03567</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SNH0"/>
    <dbReference type="OrthoDB" id="5362512at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW87873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="505" mass="57288" checksum="78F4A6B45C5B2B2E" modified="2019-01-16" version="1">MDQVYNNSLCNISATAATNSSKGLYVDRDSKQFWVDEVALNTNGVPGQPQPPVPKKVSIQDIAHQLQDTMLTNGNHVKRTKHGNSDGKSRLKVADASNSVKKYTILDLNFWETTVDQAPVNRRGWVLQERLIAPRVLHFCHDQIAWECWEKDAIESRPDGIPLLQLKAGSIVPRSRLKGMVPSVDGKALRHARLSRGRLKNGKYTDIDEDMGHAVPSVYCFEVWKRVVETYSKTRLTKATDKLIALAGIAKIMSRRILNGRDEDYVAGMWRDNLESQLLWRVDPAVKKDGTYDFHSDRPGMDEYRAPSFSWAAIDSERGINYADVTDFGRDVKDDLLIKIETVILKYKTDDRFGMLTAGGFLELKGVLKKIIIVDSMDSMEASSRRSGYTRFHWQLVRHGRVLEEPYKMIYLDAPSSDRKHIIGPNRGIYCLPVCRDRAAEPKELICLLLQAVGGVPNTFKRVGLTKISRYHKEYQDEILQPSGDENSMDCIWDAQAGRHTLRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SNM3</accession>
    <name>A0A3D8SNM3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03627</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SNM3"/>
    <dbReference type="OrthoDB" id="3539444at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW87933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="411" mass="46504" checksum="9630201582EC2D26" modified="2019-01-16" version="1">MCTVGDMVRVLQTINPNIPVDELFQNSTFTSQIRDVVNLWPEKSKKTARKILQQSGRLERRSLPSEEALRAIRRIKEIALPATLTMIYEKWQRDPSTFWNSQGLEIGSRNIYQVYRGMKQLETQRHSGTIIWRYFTMFFYDLMGLLGDGRKYLVETLQDKLVNMIDVSGLVNASKITIQKDLKRWASAGSKYCNIARVLGNGALILLPHDVTDNIWENRLPMKGACFEEAMDHLNGLGIREVSKSIGADDLGRDIREVIIRPFREIVHDQVCQADLSKSKPSLVRDPEREPVADEGVRLIGEYEDDSLQCFTDGSRIGTSVEQSEMNERLSTQARQAHVERNRLSFGRGVADDPAEESDATRGGQAQEPFTPSFDIANYLTFMPTPESSVSSQGFADEECATVGLLQFNAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SP16</accession>
    <name>A0A3D8SP16_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_03615</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SP16"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24184:SF11">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24184">
        <property type="entry name" value="SI:CH211-189E2.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13606">
        <property type="entry name" value="Ank_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="25"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="388"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="421"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="454"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="487"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="522"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW87921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="574" mass="63801" checksum="168340B44B80764E" modified="2019-01-16" version="1">MARNFTYHHEHHVYTRDEDLPFGPDGNEQRIGIGNVDKVVKKPWSSFGSLQYARKSIPIDEHDRQARELAKRRILQEAEILHHARHGHVVNMIMSYFLEGDQETRFAMIMERAEGNLGGYLNGQMTRKNLCHLSRWFGCLIGVVAYIHTLGIRHRDIKPTNILIQNKQIRLADFGISKMGLGKTMPTTIPAFARARTAGYCAPEVEEGSTRGRSADIFSLGAVFLEMLIAHSYPTKLSDLEKILRSPGGQRSYARYIDLVHQFMDGLEQEMKPDRWILKLLSHCRKMLHVERDQRPLADELGSAWSSLQSSDKPLTPCTCPGVVPATNSNKLIELCKKNSLEEVEVFLAKGADPNTVGAIHQASARGFVRVVKCFLDHNVNVNLQDYSSQTPLHCAAGYGHQGIVELLIQKGADVNLKDEEGQTALHYAAAQGCQIIVTLLLSKNADMQATDGEGRTALHFAARRGHDEVIRVLLDKGADATVKNEQGQTALHFAAGYGSVEVVRGLLTVVGNGTIDVQDKEGQTVLHFAARGKNVGGRYREVREVLKQAGANTTLKDRDKRTASSYIDENNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SY76</accession>
    <name>A0A3D8SY76_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein phosphatase 2C homolog 2</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_02375</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SY76"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.40.10:FF:000016">
        <property type="entry name" value="Protein phosphatase 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF565">
        <property type="entry name" value="AT28366P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="13">
        <location>
            <begin position="67"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="365"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="427"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00074087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW91210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="489" mass="52537" checksum="CFE9D7C8CA79B8EE" modified="2019-01-16" version="1">MGQTLSEPVVEKVGHTTGFYLRFAALDMVACQPYFLANISTAMLHGLCAPAADRPSNSATGGDDRVIFGVSSMQGWRISMEDAHATILDLQSDSGKAAKPASADERLSFFGVYDGHGGDKVALFAGEHIHEIVAKQEAFKKGDIEQALKDGFLATDRAILNDPRYEEEVSGCTASVGIISATKIYVGNAGDSRSVLGVRGRAKPLSFDHKPQNEGEKARITAAGGFVDFGRVNGNLALSRAIGDFEFKKSAELAPEQQIVTAYPDVTVHDITDDDEFLVVACDGIWDCQSSQAVVEFVRRGIAAKQDLDKICENMMDNCLASNSETGGVGCDNMTMVVIGLLRGKTKEQWYEEIAKRVAAGDGPCAPPEYAEFRGPGVHHNYDDSDSGYDVDAEQKSKSFGGNSRGRIILLGDGTEVLTDSDDTEMFDHSEEDKDLDSQVGGNKAQKPEILPEKLSTEPEHKGDADATPSTSNESAENAQKPAPEPKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYG3</accession>
    <name>A0A3D8SYG3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative 54S ribosomal protein L22</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_02465</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYG3"/>
    <dbReference type="OrthoDB" id="416470at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.470.10:FF:000017">
        <property type="entry name" value="54S ribosomal protein L22, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047867">
        <property type="entry name" value="Ribosomal_uL22_bac/org-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501">
        <property type="entry name" value="CHLOROPLAST 50S RIBOSOMAL PROTEIN L22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13501:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL22M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW91300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="323" mass="36864" checksum="45A9ACE5EB124BF2" modified="2019-01-16" version="1">MSLNAPSRRLARSAVALTTSQAPLSFLVPCIQRRTIFGWGRRQTLDTSPMPENPLTEEFLKKKPKAQQGLVRGDLSSSSIFEDEELAGPRPSELAKSAEGGKLPARNPEYMRAALDPDPDARRRWERKMVIREIHKRGRLTKTQLLKKQERESISKSHAFSTSVKKLVPLAKQIAGKTIEEAITQMRFSKKKVAKDVREHLEHAKNEAIVRRGMGLGGAEGKTFDPLMIQTKDGKRVKVTDPTTLYVDQAWCGRDLYGSTPDYRARGNVHMMKNRTTKLTVVLKEEATRVRLHEEREKKIANRKVWVQLPNRPITAQRQYYSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYS6</accession>
    <name>A0A3D8SYS6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Actin-like protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_02611</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the actin family. ARP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYS6"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10216">
        <property type="entry name" value="ASKHA_NBD_Arp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000015">
        <property type="entry name" value="Actin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000018">
        <property type="entry name" value="Actin-like protein (Centractin)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW91446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="383" mass="42651" checksum="12177F31FA6E19BE" modified="2019-01-16" version="1">MADTLHNAPIVLDNGSGTIRAGFAGDDLPKCYFPSFVGRPKHLRVLAGALEGDVFIGDRAQDLRGLLKIKYPLEHGIVTDWDDMEKIWEYVYGEGLKTLSEEAPIQHPVLLTEPPLNPRSNRDTAAQILFETFNVPALYTSIQAVLSLYASGRTTGIVLDAGDGVSHAVPVYEGFAMPSSIRRIDVAGRDVTEYMQTLLRKSGYVFHTSAEKEVVRMIKEKVSYVASDPKKEEKDWVGSKMGEGKSIEYQLPDGNKIKIGAERFRAPEILFDPEIIGLEYPGIHQIVVDAINRTDLDLRKALFGNIVLSGGSTLTKGFGDRLLHEVQRLAVKDMRIKIFAPPERKYSTWIGGSILAGLSTFRKMWVSIDDWHENPDIIHTKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZ85</accession>
    <name>A0A3D8SZ85_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_02802</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZ85"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007817">
        <property type="entry name" value="Isocyanide_synthase_DIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37285">
        <property type="entry name" value="SPORE WALL MATURATION PROTEIN DIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37285:SF5">
        <property type="entry name" value="SPORE WALL MATURATION PROTEIN DIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05141">
        <property type="entry name" value="DIT1_PvcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="3">
        <location>
            <begin position="441"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW91637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="690" mass="77558" checksum="59F9A4ED4FF8A06F" modified="2019-01-16" version="1">MPSEIPGTGNSCNLWNLLSKNASSQGGSYFSESCQMTAREESSSDSDHGSLSDDSTKTTVTEPDEGVTTIEDILLNRAKTENPYLTDADVEISDRIMRILCSYSPATRKSVDRSTIENMVSSTVGRKQPIHLVLPAFPFKSPNNIEKVLGKLPDKGEELALHTLDGLCAQIDEFYPGTTLSIISDGLVYNDLLGVTDEDVWNYGSALRKLAREKFPRISFARLSKLISDDCPEPLTREDYLEHAAWYRSEVISKNLPKDFDVNLEIKHQINSLLTYRGYIKFLATDLKHEPSRQGKTNSQVKKMNEKVAKKMIHRGAAFTLAIQKAFPSSIRISIHESESKYKLAIALFSGGQAYTTPWHCVCALELDGSWRYAHKQAIASDSAYELICKDGRPSYYRRKSDLYSWDNCSIEVDPIYPCGLKITPTQVDTELSMSVIDMGKIRKLSEYNSPIVLRGFKNTTDLSLFTAKAREMGAVMTWIFGEVLVVKDAGSESGGLNNVLSPEPMPMHFDGNFKTKMVKDENGEERAAPMPPKFQWFTVATPAPKSCGFTLVASSRILFSLLPKPFTLEQLQKLTWTVKTAAFNNSTIYRLNLVEPHPTHLTPCLRYHEPWPSTKTRFDATHVTIDGFSPEESKKLTDTLNSLLYDRRVCYYHEWVEGDLILSDNVSTLHTRTGFTPGAPRELWRILID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZB5</accession>
    <name>A0A3D8SZB5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase C14 caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_02832</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZB5"/>
    <dbReference type="OrthoDB" id="4760831at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="2">
        <location>
            <begin position="93"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW91667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="526" mass="58772" checksum="62D365C646F018B1" modified="2019-01-16" version="1">MTTQILTSDSSLDEGHEKLPALPNGQLDADATIPSTHDRPSFSEIQSETASINDKLRNSWEESMKGFGSTGTPKKKAAVLMISWHESIDDMDTSEEVEKLGSVFEKQFRYTVIKKELTRERPSHQINTYLSSFVMDYDDDSTLLIVYYAGHGMGNKPGELHLTGCTGNGDPTDYLLTRDSIPWHDTEFLLKNVTADVLLIFDCCYAGNLTPTIQGRGQIWPTRGFEYLAACPYNECTHPPGRKSFTTALIWALDSLLKARGTFTTHELQQKIMKEAPNFPRKQIVEIQERGQPCDQRLVLAPLPEPNSSENGSGVSDGRVPPQNFIDLRVWYSIAPNEAEIRTLASIMRRIIIDRKITASNIAWVHFGNHMDPVRKVLDKWQSLLSPGLGQRLRSTPTNLNHEIRLGDQGDLQPPHTPPPSDSGRSSMEDGHTKLPQPVEGYSCVYSSALGQDENVGEFHKSVSEISVDILEEGELRTPEDMLTTDHCVKSLTTWMCNPISLVACTALYICVDRLVLRPSLSYRPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZX7</accession>
    <name>A0A3D8SZX7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_01250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZX7"/>
    <dbReference type="OrthoDB" id="3471929at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="48"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="638" mass="72843" checksum="38ADDAAC11C16764" modified="2019-01-16" version="1">MASFTYTHLSLDDPTQQIRLVSLDCTASDDEPISCSIHHIDTNAEVSYAALSYAWGEPAPTSSIWLDGQPYRVTRSVRAALEVLRRQGREWDYTTRLLWIDAICIDQSTYHERTQQVQIMSTIYQRAHHVFVWLGQYYERDDNLELQRNIWGFSRVVPGTPAIMQAIFQLLNDLNVTCSSMFGIDQYFQSPRKPTLDYQCWAYLSILFRRPWFERLWVIQELAMARKTVVYCGDCMVEWRVLEHAARAISAHIAAKDISPIGQLPFIYNIYHQNVTIPSLQGVDRTNMLALIYRTRRSKAREPLDRLFAVKGLLQNAEIDIPNPDTDTLIDYSSPPEAAYREWAFKRMHRTKSLDVLTLCTDRYRQQDAKNNGWRSWVPDLRDLTGIDESLFFLGNRINSDPRNTLYAAARATECVPRLIGQTVLTPSRLSIQGISIGRIVKLAPPSRQLGPSVTKEQLTIAMAAWEELVLDHFGWPSEGEPSNSLLSAFVDTIFRGHVAYGEDGNFASFFHRYKVWRGIATISPSFNPRSYEEDRAKDYLGLFETVLALMIGNTNLFITSDNSIGVISSHCHAAVGDEIFVFLGANAPYVVRETPKLLDQCTLHQLLGPCYVNGYMQGRAIDEWERELKALVTIDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T066</accession>
    <name>A0A3D8T066_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-polygalacturonase</fullName>
            <ecNumber evidence="3">3.2.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BP5796_01215</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(1,4-alpha-D-galacturonosyl)n+m + H2O = (1,4-alpha-D-galacturonosyl)n + (1,4-alpha-D-galacturonosyl)m.</text>
            <dbReference type="EC" id="3.2.1.15"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.15" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T066"/>
    <dbReference type="OrthoDB" id="1546079at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000002">
        <property type="entry name" value="Endopolygalacturonase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050434">
        <property type="entry name" value="Glycosyl_hydrlase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884:SF1">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017673001" description="endo-polygalacturonase" evidence="14">
        <location>
            <begin position="21"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDW91821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="377" mass="38553" checksum="D92881A80C79A328" modified="2019-01-16" version="1">MVQLSTLLSLATASISLVAAAPAPPTVTAAPSLEKRASCTFTNAASVSKSKTSCATIVLDNIAVPSGVTLDLTGLTKGTHVIFEGETSFGYEEWSGPLVSVSGTDITVTANSGAYLNGNGQKWWDGEGSNGGKTKPKFFYAHKMISSSITGLIFKNTPVQMMSINNSEDLTITGVHQQNTAGDSEGHNTDAFDVGSSTGITISGAVINNQDDCLAVNSGTDITFTGGSCSGGHGLSIGSVGGRSDNDVKTVNILSSTIKNSQNGVRIKTVYGATGTVSGVTYKDITLSGITKYGIVIEQDYKNGSPTGTATTGVPITDLTVENVKGTVASSGVNYYILCGSSSSCSGWTWSGNSVTGGEKTKTCSHVPSVAATTNCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0F1</accession>
    <name>A0A3D8T0F1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative KH protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_01408</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0F1"/>
    <dbReference type="OrthoDB" id="271862at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22453">
        <property type="entry name" value="KH-I_MUG60_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056553">
        <property type="entry name" value="KH_Mug60-KHD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627:SF76">
        <property type="entry name" value="KH DOMAIN-CONTAINING PROTEIN YLL032C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10627">
        <property type="entry name" value="SCP160"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24563">
        <property type="entry name" value="KH_Mug60-KHD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="258"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="484"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="554"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="639"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="823"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="860"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="901"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="877"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="956"/>
            <end position="966"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW92014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="976" mass="108884" checksum="DDC23D28031348D1" modified="2019-01-16" version="1">MNKLANMRHWSERMGPGFGMSRPNMNMNAMPPQQQKTHANSPIMSPQPQDTPIHYSFNVPFASELTGPNTEDIIYATTDAIQRWTHPEDAPDDVPVHELPVHANNLANLKRLCKDITSAPTLIEAHVKSFQPKRIKGQVTNVCLSGTPDLVHQTRDRILNETPLALRCAVVDINGDLLLDDSESAIKQQVLSHLDDISIFCGVDVFLLGPKIASLAEGLNTNGDAGRDQRWRVAIYGDMESAEHAKTRVLILIDRLLGRVVDAMKLELSLHTVLCGRSRKNIKLIESATNTAIYFPPPSSRIYRYVPAGAEQRNPEEVFITGDGPQNIAMAKQKIHELVTRVRLFMKDAVVSAAKIDSILLTRLDKVRKIMETNGTFIQFPQLASQRNMIRIQGVEGLHVERTVRDIMSLTGQFYSASWWIQNTDITRTPSPSDIRTMLSDICANSDADVSFDKLTFTITGSDDAVKAALMVISEIRFVTRSQYQIRVKIELANEHKEFVSGKKNGKINKIMGQSSVQIIFDGFNEYNFNIDVCGGNYEAMKSGLMLVEQEMPASISFHVPDQYHKRIIGIGGQHIQRIMKKHSVFVKFSNAMDRGGVGREDDDIKVDNVICRTPARNAQNLELVKSEILDMVDRVDSEFTSQTVNVDRLYHRQLIARLSQLEELERKWNCKIIFPSTEQASDDVTVSGPEWQVPHCVDEFLGMVPDNHELVLARTPELMKYFESPDFKTDLVSKLKSQYVVEVQVKEDANERTEDDGPTVTLLWGFTRNNAGGVRDAIDFLHSNLATAGIETTTVKGAIPRPKSDSFEESLQYFDSKLLQHAPAPVSTDSPTKSSFGDDVARERSTIFDKLRKPGSMSSISSFLDRRKNSSHSPAGSFFKNGSSNVSKSSLISIESTRSFNADRNPWNDSGVNLPDDDTTPWPTRPFGTGNELKPNPQFSHPGDATPRHALDSGRPSTSHSSNSGYPGPIGPPRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0G1</accession>
    <name>A0A3D8T0G1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA-binding S4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_01447</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0G1"/>
    <dbReference type="OrthoDB" id="3356781at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005763">
        <property type="term" value="C:mitochondrial small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF4">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US4M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="9">
        <location>
            <begin position="133"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="215"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="345"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW92053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="456" mass="52447" checksum="A73AA2E60DD78A0E" modified="2019-01-16" version="1">MPRSRSFHTLKRLGGGKIRQSWNKINLYNLSRLLSRPAGVTHYQQKWKAKSTTRAYHGEQIREKHWERMFRSRLRAEIPMDINYLARHDGSELAAGRGSGRETRPRDAINLRTNNKKSFRIPYMHMTYAPMERRLDTAVFRSLFASSARQARQFVIHGKVKVNGKKMPYPGYMLNPGDMFSVDPEAVLFATGAPKDQEAVRSGRRLKRMQQHEARQEAEAQKAAEIRRTKALEAKRAQEEEENSQQEADAAALKQERENLDEAQLKKVQRKQINELVETAQVLIRDTQNEPSAKRKVELRSFVKSAKTVSNKMQRKDPEQVDKEIEELVTSFAKLTPSPPQAGEAAKREAKASKAAAEEKEALDTEFKKEYQKSLDAIMQARYAATDESKPYATPWRPRNYMSAFAFIPQYLEVNQNICAAVYLRHPIAKPNAAEVPSPFGEEVQQLAFGWYLRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0Q1</accession>
    <name>A0A3D8T0Q1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rRNA-processing protein FYV7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_01537</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0Q1"/>
    <dbReference type="OrthoDB" id="2135053at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41805">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41805:SF1">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN FYV7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW92143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="24521" checksum="8AE702A87805F980" modified="2019-01-16" version="1">MAPKRPIEDDVESSKPKKARSKFNVGPDNLPDGTWRRKVIKIKHDMIHKAKVKKAYAKIQAQEPAATTTKSVYELPTETEDKEEGREEEATTAEPSQELHPERQAMLSAPIPTPLPDQSEVYEKRISQTRKGKRPAYFEKEQSFAQQKKEEAEARRLEFERREKEKRERIEERERFRKAMAKARTGGKNGQRKLGRESKVLLERVKRVVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0T9</accession>
    <name>A0A3D8T0T9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_01534</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0T9"/>
    <dbReference type="OrthoDB" id="10367067at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW92140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="332" mass="37355" checksum="FF2D1DCB0873B2D0" modified="2019-01-16" version="1">MAPSSAKEKQPRLRSFLRREILRSRLKASCKPRNKAGDHPKPVNFILESKSPSVSQPSLQAPTIDEGFVDSLFGDPIVPVQNDLTSLELFLKQGASGVEQKNKEATDVEFESMKNDYLALLDAEPAISYNKDTLPEPIHPYEKRKLMRTARQVNEARKGIMENPKEPLKQGSKMPGESVEETEDWDGEALLHMYNHPPKHKTRPEKLSPVPPDVQEITKIYNRASERALGRFLQQDLLEQSKGVKRKGLGRKGRMAEKELLEYENEVKRMKAVSESALKASLAQEKGNEMGKKATEMGVMGDMRSYTQYLYSEASGPAGKLFGKIWKDGAPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1A7</accession>
    <name>A0A3D8T1A7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Transaldolase</fullName>
            <ecNumber evidence="2">2.2.1.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_01749</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:17053"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:57483"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="2.2.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; pentose phosphate pathway; D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage): step 2/3.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.2.1.2" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1A7"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00414"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004801">
        <property type="term" value="F:transaldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009052">
        <property type="term" value="P:pentose-phosphate shunt, non-oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001585">
        <property type="entry name" value="TAL/FSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018225">
        <property type="entry name" value="Transaldolase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10683:SF34">
        <property type="entry name" value="TRANSALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00923">
        <property type="entry name" value="TAL_FSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00958">
        <property type="entry name" value="TRANSALDOLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0704">Schiff base</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW92355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="325" mass="35906" checksum="BFBD4D9FB8276CFE" modified="2019-01-16" version="1">MAASQTLLQLLQSRSIVDCDTMDLEVPKSLGPFVDCTSNQAIAYNELLKPEHQELIKKAIEASKTLTEEYPELTAAQLATEIAMIKLQLEISKVVTGFVHVQTNPYFSYSVPKTVANAKRIVQLFKHVDSNFDVSRVCIKIPSSWEGLKACQELEAGGITTLATTLFNIEQAAFAGEVGCHYIAPYVNELRVHFDPGFVDEHKAQTLCFESQRYYEKYNLKTQVLPASLTSTTEIMALAGVHHITIAPALLRELAATPASANTTTSLFDSTTTTFEPAGLMSFKDDEAGFRIAFTRSGKGEGERKLSQAVNIFCDMQDKMETMLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1I4</accession>
    <name>A0A3D8T1I4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_01826</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18597">
        <property type="entry name" value="ABC_6TM_YOR1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18606">
        <property type="entry name" value="ABC_6TM_YOR1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000010">
        <property type="entry name" value="Multidrug resistance-associated ABC transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF464">
        <property type="entry name" value="ABC-TYPE TRANSPORTER CICA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="314"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="421"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="819"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="859"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="936"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="959"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1046"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="140"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="498"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="824"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1140"/>
            <end position="1398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="233"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="500"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="750"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="240"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW92432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1417" mass="156825" checksum="65366AC063CA1C1E" modified="2019-01-16" version="1">MESRTSNDGKKTPAVSSTPSSEASQDVESNHEKTGKGQSRSWLRNPLRTKIPPVPTERRRSPEETANILSRVTFDWMNRLLYVGYKRTLTETDFPLLNESRRAELKSEKIKASLRKRAARGDKHALLFSLWDTFWVEYSLASVSMLATTCIQALSPQVLKVILTYATESYYNEAPPIGRGVGLVLALVAMLTLSAFAVNQWVFRGLVVGGMARASLISLIYSKSLVISSRAKAGGMTSDNKNDAHEKKPAKKSSEPDSKRHDFHGWSNGKVMNLMSTDTAHIDQAAMWTHMLYSMPLQIIIVIVLLIINIGVSALAGVALFAIIMPALAWSAKRLATRRVAMKKITDKRLGLTQEILQSVRFVKFFGWENSFLQQLKSLRRTEIRSIQVLLGIRSAMNAVTVSAPILAAMLAFVTYSLTHANLQAANIFSSLALFYGLRIPLNMLPMVIAQTIDAYVSIGRIQDYLLAEEEVETREVDDTLEHAFEVTDADFTWENAMKPEDVSKEKSGGSNKSAADDPEKGIPSDASSSATEEDEAFHFDKLRISIARKELLAVVGGVASGKTSFLAALAGVMRKTAGTVKQGTNMAYCPQHAWIQSSSVRDNITFGREFEQEWYDLVVDACALRPDFDMLPDGDATEVGERGITLSGGQKQRLNIARAIYFDAGIVLLDDPLSAVDAQVGRHIFKEAICGLLKEKCRVLATHQLHVLSQCDRIIWMQNGKIEAIGTFDELMATNSGFVQMLSMTAKNEEKPPVEANEADGAVADSTEKSTEEDLQPVPKAASQPILPAATLMQKEEKGEKGIKWQIYRAYMKASGSYLTLPFAFFLLCLAQASNIMSTVWLSYWTSNSLHIANNTYIGVYCGLAIAQALLMFGFSMGLTIGGTKASKAFLQRAMQSVLKAPMYFFDTTPLGRIVNRFSKDVDVMDNFLSEAIRLYLFTLVQIVSIFILIIVYFPEFIAALVPLCGLYYFVASYYRSSAREIKRNEAVLRSDVFAKFSEGLSGTSTIRAYGIGNIFEKKLNDSINSMDSVYFLTFSNQAWLSIRLDIIGILLALIVAMLVVSNRFNLDPSTAGTILTYMLQVIGMVQFMIKQLAEVENSMNSTERVYNYGSELPQEANVIGDATTEVKAPATWPESGGIKFNNVEMRYRDGLPLTLKGLDVQVRGGERIGIVGRTGAGKSSIMSCLFRLTELSGGNIEIDGIDIAKVSLQHLRSRLSIIPQDPTLFQGTVRSNLDPFNEHSDLELWHALQQAYLVPQASEPIVETDNPESDEVRAASSKEQSKINKITLETTVLEEGQNFSLGQRQLMALARALVRGSRIIICDEATSSIDEETDRKIQETMAVGFKGRTVLCIAHRLLTILNYDRIVVIDNGRIAECGTPWELWNQTGETGLFRGMCDKAKIRRENFGVEGNVGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1T6</accession>
    <name>A0A3D8T1T6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Shikimate dehydrogenase substrate binding-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_01898</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1T6"/>
    <dbReference type="OrthoDB" id="204377at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019632">
        <property type="term" value="P:shikimate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022893">
        <property type="entry name" value="Shikimate_DH_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089:SF1">
        <property type="entry name" value="BIFUNCTIONAL 3-DEHYDROQUINATE DEHYDRATASE_SHIKIMATE DEHYDROGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21089">
        <property type="entry name" value="SHIKIMATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="1">
        <location>
            <begin position="19"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW92504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="311" mass="34498" checksum="FF8A14A4319E950D" modified="2019-01-16" version="1">MATEPLTPDSTHLERVGYLFGFPIAHSLSPLLHQTIYDHLFPPRKWSQLFLESVDIPNFLRLTKEPKFYGASVTMPHKVAIIPFLDEITQEGKEIGACNTVFLREKDGKRILVGTNTDTIGIREAFYQNLKPGQSPEIFKGKPGLVIGGGGACRSAVYALERFMGCSPIYIVNRDVAEVDAVLSSGISKNLIHIKTVADAQAAIAPSAIVSCIPDFPPKTPEELEARAVIEVFLEKPEKGAILEMCYHPSPFTQIAALSEKNGWQLILGTEAMIYQGLEQDRYWTGVEVKDLPREKVKEVILDALNKARKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1X5</accession>
    <name>A0A3D8T1X5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MYND-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_01938</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1X5"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="4">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW92544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="185" mass="20080" checksum="13B1569DC54CAD96" modified="2019-01-16" version="1">MAPSQRFPNFTSPRTFPTFQALPLTNPPSLPGVTYPSAADLSSPYFLLGTLKENMTLSSNPTYILQDCAGQNFACVLRVPDSTASSPKFAVDGLKKGQTLVLANPTRGGVKEGKQGHVAANLEEVLILPTKVERLMELSIRVKSEQVQREGEVEEGEEVCQACGKKGDKLLRCKGCESAWYCDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T2E8</accession>
    <name>A0A3D8T2E8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2'-phosphotransferase</fullName>
            <ecNumber evidence="2">2.7.1.160</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_01572</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP-alpha-D-ribose 1'',2''-cyclic phosphate + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:23324"/>
            <dbReference type="Rhea" id="RHEA-COMP:11106"/>
            <dbReference type="Rhea" id="RHEA-COMP:11107"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:76596"/>
            <dbReference type="ChEBI" id="CHEBI:82883"/>
            <dbReference type="ChEBI" id="CHEBI:85027"/>
            <dbReference type="EC" id="2.7.1.160"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.160" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T2E8"/>
    <dbReference type="OrthoDB" id="419694at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000215">
        <property type="term" value="F:tRNA 2'-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="entry name" value="RNA 2'-phosphotransferase, Tpt1/KptA family, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PUTATIVE PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684:SF2">
        <property type="entry name" value="TRNA 2'-PHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="296"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW92178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="329" mass="34974" checksum="F5FA6F61FADD4E99" modified="2019-01-16" version="1">MTAVLQQMPGLALDGGIMAPSPVSPGAARHGRSKHGGSVVKKTRGRGYSVVDDREVTISKAISFVLKRTTEEGEEEEEGKLVASDGWVDCEEVLQHPNMAALEVTLSELLAVVESSASKGRFAVRRDPDAAAETTDPSDYEIRLAPIMTPTSSSPTADSAADKLTPLTTASADLPDMIVYETSYPNYPLVLASGGIKRAGGQAVLQFKSIKVDEDGNEIRAASTADVSIQINLRAIMEADDKIRWARAENGNIVTEGDAKGSIPKEFWTKAVARRSDIGVLFENGEVRKEIPIGLRGKGVKGKKGSGKGKGWVSKEMKASSEDDGSSSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T334</accession>
    <name>A0A3D8T334_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_01802</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T334"/>
    <dbReference type="OrthoDB" id="302966at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16536">
        <property type="entry name" value="RING-HC_RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000512">
        <property type="entry name" value="RING finger domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039739">
        <property type="entry name" value="MAG2/RNF10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983">
        <property type="entry name" value="RING FINGER 10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="181"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="358"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="413"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="543"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="689"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="429"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="543"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="610"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="713"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW92408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="722" mass="80678" checksum="5369D4986BA22609" modified="2019-01-16" version="1">MTSNPPNAALSGGKLNTTSTHSPVQHQQSVTSPGFESSSRRSGSSITAALPRNGQSQRKQHKNARKPRLADEDAMAESRVIRNANGRRGQTSITHLMNITLPPRPQYNQHSMGRGTRRGNIYGIGSGHHASDKARYIHANYRFIVKPNGDYKQQAVNADQHLDWNDVLQILASAESQASACPICLSPPVAPRMAKCGHIFCLPCLIRYMHSTDDTNSIPEKKARWKKCPICWDTVYISETRPVRWYIGQEGPAPREGDDVVLRLVMRQPGSTLALPRDGADALAKSDDIPWFFAAEVTDYARVMKGSEDYMTEQYESEIEELRRQEKEDELMFGEETEWTTKAVNSIKDAKERIKDIGNAPAPQQPTEKKPKRQPIQFNQTDDGVPEMYLIQHATKSGRSMSSTLSASAYTPYSAETGSELPPERGALQDNQSSRSKPAQHDTSGAHRPDEPYYFYQALLHYYLAPLDIRILKSAFGHFSSFPATLLPRVERVSTGHIMDDDLRKRTKYLAHLPYGCEVGFLECNWTDVVSPEVLAQFKEEIERRRKRNRDKENREEKDRARAEKEEEDKRWASARRRRPETAEDSFQEDFSIASTSLDASHASPPWPTRQGSSFATLASPSTSPSDNTMPSLSHAGPKTVWGTTLVAPSSPETHPQIPEDVDDGWLQSWEQELLAENELIAKAQAASLEGGVGSSSVPEPKGKKKKAKKITLMSTTARRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T3U4</accession>
    <name>A0A3D8T3U4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_02062</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T3U4"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050314">
        <property type="entry name" value="Glycosyl_Hydrlase_18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11177:SF333">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="7 9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="11">
        <location>
            <begin position="105"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="731"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1065"/>
            <end position="1091"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW92668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1091" mass="116495" checksum="AABEE49C6D82DFBB" modified="2019-01-16" version="1">MVHVVERMASVVTHPLNAQAQPVYQTATPRQNAESTRHQLRPVAPSMSAAHTLGSAVPLILVMDENLTNTNEDFCLTTGDTPCQDGYGSCGNVTEPSCSGASTKTRSIGYYESWSSTRTCDSRKPSDLDLTGLSHINFAFAFFNPTTFEMSPMDSGDPTLYSEFADVKSNYPGRMVFQCTSIILAIYGDVKRNSLRQDDTNSPNTRTAFSDMVSSSSNRAAFISSLSSFMQTYGFDGVDLDWEYPAATDRGGVAADTANFVSLVKELRSEFGSKKGVTATLPSSFWYLQGFDVAGMADYVNWFNFMSYDIHGTWDSTSKFTGPYIRPHTNWTEITQGLDLLWRAGVSPDKVTLGLGWYGRSFTLTDETCVTPNGVCMFSAGGSPGECTASSGTLSNAEILRVIDEYSLEPTYDDVAAVNWIFWEGSQWVSYDDGVSMQAKIDRANALCLGGTMIWSIDQDNTNYDSMSNFLGIGPTNGNTAEQTTLLKEQLAVATTATSVQTSCYWSFCGKGCDDAYYPVTQAKGEIGNNGADASINTVCTGTDVQSLCCAPGTTLGTCQWEGWNGVGMACTASCSNDSAIVIAENTNHYYSDPDTSTLEDQTCNGGFQAYCCLGFVASSKANTGSLDLIDQTTSSKRSLEKRGLNTAVARVCLSAAEIAVEAIAAAAAAWFTFGVSEVVFAAEVAANVICLALAAAATVEAAVAAAAAASVGTSVAIGVAAHAMVLRTKRPAGGSQSGSAPKKPKTGNSGGAKSVYGQWNIATYPTTSDATSCDCSVTYTCVYGMTATAGGWDEICDNQRYAIDKLLNGRLGDSNYAKAQWSPQHSGWQAAAQTAVNNVARCQVDEFPMGSLAEGVLPNPQACRLVNGPANGRQGSDFQQFLLAQYIPCSSYKENVCSTASPVVPITWAFSGMDAVRSAGSTAAPHFVQYYGFDSQTAGSECWATASFNDPSGNPVISTVADHGFRVLNNDPMITNAAYNWPLQSYRPSPFAAQVGQPSSIASAQFQKRQEVLASLRGERPEYDIDCAKCDVFIDKAGREFHQPHWRRHHRHFPSQVVTTTAAAPEGTNAASSAGSTPVHKVPRETGVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T6V2</accession>
    <name>A0A3D8T6V2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_00085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T6V2"/>
    <dbReference type="OrthoDB" id="5427070at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW94322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="152" mass="17782" checksum="6D7F60C9CB1593C3" modified="2019-01-16" version="1">MGATWSLLKTLVIPALISLILYLLISFVVVPVWRRYRVRYGQYLPVDAISTRTTSLRQRIQNAIARSLVPSSWRADLEQHRYPMSTDRTSSDFDEEEGEELYEVNDRRREALSLDVRRGRDDNRRLSRDLEEGFKDDSSDDEEEERPGRSTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T6V5</accession>
    <name>A0A3D8T6V5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative bifunctional fatty acid transporter synthetase (FAT1)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_00032</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T6V5"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044539">
        <property type="term" value="P:long-chain fatty acid import into cell"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107:SF20">
        <property type="entry name" value="FATTY ACID TRANSPORTER_ACYL-COA SYNTHETASE (FAT1), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G11360)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43107">
        <property type="entry name" value="LONG-CHAIN FATTY ACID TRANSPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="136"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="578"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW94269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="726" mass="80350" checksum="4B7D685AD14C2CE8" modified="2019-01-16" version="1">MPPPTRGIPPLPRDARESQGVLAPVGVPHPCRSDLMGVVVGIDKHDVVWYFEQLEKSAWVWLRFLNSITMATLPLNALALGLPAAIAAGAYINAKFALATDWKTIRHDREWTQRLQNRLKEAGGNCTFWGMFDRVDPSAEFLWFEGRTWTYGDIKIEVKKFAKVLQDNGIGTGDFVAVFTANSPEMVVSILAISRLGAVGALINTNLRGDTFIHCMNISRAKFIISTPDLTPHVLGDLPHISLNMGSFENVTAEVVSQNKVPIQSIDLRAQSYPQITTPPPPRKPSDLSVLIYTSGTTGRPKACAIRNMQTYVTSNPLSLDLDGPGKYLPVRTYSPLPLFHGTGLFTGFSYTLGTGGSLCIARKFSSSRFFKDVHDSKATRILYIGELCRYLLASAPSKYDKDHNCVTASGNGLRREIWNEFKERFNIPEIREFYRSTEGVAKFDNFGRAAWGAGKIGFAGPLRRALEEDTFVIRSDPSTGEPIRDPKTGFCIRCGLEEPGEAIGRVKDRGLLTEYLGNEAATEEKLLRDVFKKGDLYHRMGDLVVVDNDGWVRFHDRIGDSFRWKGENVSAGEVRDLICELSNVQDAVVFGVRLKSYDGQAGGAVISLKQNSREEREKLAKSLHRFLRKKGLPAYACPRLVRIAERYAAALSPPSVHLGPATDYANSSIGTGVTFKQGKGEEAKKGWAPAEYVGKTETLYWLDGSQYRVLDEGAWESIEAGKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T6W7</accession>
    <name>A0A3D8T6W7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_00058</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T6W7"/>
    <dbReference type="OrthoDB" id="1898221at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF149">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="2"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="4">
        <location>
            <begin position="182"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW94295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="281" mass="30900" checksum="769B91C41E8C310B" modified="2019-01-16" version="1">MYTGGPTYWMPKFEFSKFLEYNKQHRITYMLTVPPIYLLIAKSPLVTDQFDSLKVAVTAAAPLGKDLQYAASMKLGRGETFISQVWGMTETTGSVTGFSPEERDDTGSISVLLPGQPEEFLVKGPVVTRGYYDNAKATKESFTSDGWLCTGDVGSERNGLFYIVDRKQELIKYKGLQVAPAELEAILMSHDQILDAAVIGVDGTGYSEGTEVPRAYIVPAPGGISKEEIMKLVEGKVAQHKKLRGGVVFRDVILKSPSGKILRKEFRALAKKEKEGTSSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T6X4</accession>
    <name>A0A3D8T6X4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucose-repressible protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_00070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T6X4"/>
    <dbReference type="OrthoDB" id="10039103at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020100">
        <property type="entry name" value="Glc-repressible_Grg1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38789:SF1">
        <property type="entry name" value="GLUCOSE-REPRESSIBLE GENE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38789">
        <property type="entry name" value="REPRESSIBLE PROTEIN GRG1, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14210)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11034">
        <property type="entry name" value="Grg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW94307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="71" mass="7428" checksum="250AF863EA48D5D1" modified="2019-01-16" version="1">MESIKNAANYVSETVQGTGAEASKEANKNVAKDSDASLSSRATAAKDAIVDKKDESSHNAKADVHKEAAKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8G8</accession>
    <name>A0A3D8T8G8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dynamin GTPase</fullName>
            <ecNumber evidence="3">3.6.5.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BP5796_00645</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.5" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8G8"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061024">
        <property type="term" value="P:membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031623">
        <property type="term" value="P:receptor internalization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000741">
        <property type="entry name" value="Putative mitochondrial dynamin GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019762">
        <property type="entry name" value="Dynamin_GTPase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056495">
        <property type="entry name" value="LIS_MGM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF212">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24550">
        <property type="entry name" value="LIS_MGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00410">
        <property type="entry name" value="G_DYNAMIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="13 17" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Dynamin-type G" evidence="21">
        <location>
            <begin position="254"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="20">
        <location>
            <begin position="821"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="914"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="914"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RDW94882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="938" mass="102700" checksum="AA57F5DE0CDE04B7" modified="2019-01-16" version="1">MRVKLMISTSIPPPSQPSAWALPQAQRAVTQAARGFHHHTSSTAGGLLRSDAAVRSARRRIWPVGITPFSNAVAVRNASFVRILPRLFLNFFRLPALLGGATIAGFTYIQYQAAQAGTYAMDILNRTKDTVTGVAGGFFGSAKDIADQTRRGWQNTTSEVELPEWMQKVLRIHEEIGEGKGNEGHGGPGGEPPKESRLGAAAIGGSAAAYGYDQSTEEDSRSNEEAARDDQMMVLTKKMIEIRSILQTVGQSSALTLPSIVVIGSQSSGKSSVLEAIVGHEFLPKGSNMVTRRPIELTLVNTPDAQAEYGEFPALGLGKITDFSSIQRTLTELNLAVPDSECVTDDPIQLTISSPHVPDLTLIDLPGYIQVVGHDQPSELKQKISDLCDKYIQPPNVILAISAADVDLANSTALRASRRVDPRGERTIGVVTKMDLVDAPRGASILNDKKYPLRLGYVGVVSRVPPQTTGLFKKGSGSISAAISKNENAFFSAHPIEYGPEAGLSVGTTTLRKKLMHVLEQTMAASLQSTSDAIKQELEEATYEFKVQYNDRPLSAESYLAESLDAFKHSFKEFTEHFGRPQVREMLKEELAQRVLDLLAARYWNKPVPDLSPAPPEPDSLADLPNADPESLYWHRKLDASTSALTKLGVGRVATSVVANAIQAHIDRLIAQSTFASHPFARQAITEAASGILNERYYSTSDQVENCIKPYKFEIDMEDGEWSKGRENVAGVLKNELQACEAAVKNVEDTVGGRRKLRDVMTFVDRARKGDVVVEGDGASGAGGFSSALLQKGREAVFLRDRASILRMRLAALKSKQCASMKNKYYCPEIFLDVVATKLTSTAVLFLNVELLSEFNYNFPRELDIRLGRGLGKDEVERFAREDPKIKAHLEVIRRKELLELVLSKMDGLRALEVEGKSRRPSPPDRKKEQGRGGWSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8L5</accession>
    <name>A0A3D8T8L5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pyrimidine monooxygenase RutA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_00695</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8L5"/>
    <dbReference type="OrthoDB" id="2558704at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008726">
        <property type="term" value="F:alkanesulfonate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046306">
        <property type="term" value="P:alkanesulfonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006212">
        <property type="term" value="P:uracil catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01094">
        <property type="entry name" value="Alkanesulfonate_monoxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01699">
        <property type="entry name" value="RutA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019914">
        <property type="entry name" value="Pyrimidine_monooxygenase_RutA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050172">
        <property type="entry name" value="SsuD_RutA_monooxygenase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03612">
        <property type="entry name" value="RutA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42847">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42847:SF4">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="5 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="6">
        <location>
            <begin position="1"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW94932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="359" mass="39337" checksum="00B4C31E7A48929A" modified="2019-01-16" version="1">MEIGVFIPIGNNGWLISDNSPTYMPSFELNKQIVQKAESYGLDFALSMIKLRGFGGRTEHWDHNLESFTLMAGIAAVTSRIKLFASTAILTLPPALCARMAVTIDSIAPGRFGVNIVTGWQAAEYEQMSLWPGNAYFGYRYDYAEEYVKVMKDLWTNGSSDFKGKHFTMNDCKLSPKPSQPIKIVAAGQSPRGVEFAANFADYNFCGASGHNTPKTFEKGNQALVEAATKAGRDVGAMVLFMIIVYETDDEAWAKWDWYSKGVDLDATSWVTSQATKDSNAASTSTASRISRNDNPVNLNGGALIGSYKTVAKHLDEAAEIAGTKGIMLIFDDFLLGLDKFGKHVQPLMKSRSHVKMAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T949</accession>
    <name>A0A3D8T949_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_00818</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T949"/>
    <dbReference type="OrthoDB" id="9991913at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030267">
        <property type="term" value="F:glyoxylate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016618">
        <property type="term" value="F:hydroxypyruvate reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12168">
        <property type="entry name" value="Mand_dh_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000526">
        <property type="entry name" value="D-mandelate dehydrogenase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050223">
        <property type="entry name" value="D-isomer_2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996">
        <property type="entry name" value="2-HYDROXYACID DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10996:SF281">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE NAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="2">
        <location>
            <begin position="124"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW95055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="346" mass="38517" checksum="E13DDF3B77DE679F" modified="2019-01-16" version="1">MAPSLVSPNKPIVLHIGDPVKWNLDQFSEFSKDFTIIRPSLSERQRPEFMKALQDKRWGDFAAIFRPFWNTGGEMGRWDRDLIPLLPESCRIFAAAGAGFDWADVDLLAERAASESVADFALFQILATFRHLNWCTTSARSTTAAFTECHMDAPALSHNPRNHTLGIIGLGAIGQLIAQKAHLAFGMRIRYFDIVRKSDQIEMSLSATFDADLDGMLRECDCVVLATPASPDGRKIIDAERLKHFKTGSRFVNIARGVLVDEEALADALDEGRLCAAALDVHEHEPVPNERLKDMRNVTLTTHNAGGTLETHIGFESWSMRNIDAVLKGREPLTPVNLHLFPSVEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9G7</accession>
    <name>A0A3D8T9G7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Potassium transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_00966</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TrkH potassium transport family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9G7"/>
    <dbReference type="OrthoDB" id="9999863at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140107">
        <property type="term" value="F:high-affinity potassium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030007">
        <property type="term" value="P:intracellular potassium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003445">
        <property type="entry name" value="Cat_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004773">
        <property type="entry name" value="K/Na_transp_Trk1/HKT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015958">
        <property type="entry name" value="Trk1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051143">
        <property type="entry name" value="TrkH_K-transport"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00934">
        <property type="entry name" value="2a38euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064:SF30">
        <property type="entry name" value="HIGH-AFFINITY POTASSIUM TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31064">
        <property type="entry name" value="POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02386">
        <property type="entry name" value="TrkH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002450">
        <property type="entry name" value="K+_transpter_TRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="4 10" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017606829" description="Potassium transport protein" evidence="12">
        <location>
            <begin position="16"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="31"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="433"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="503"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="567"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="632"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="687"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="716"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="743"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="127"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="783"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="185"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="783"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="824"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="857"/>
            <end position="871"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR002450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW95203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="927" mass="104343" checksum="AFF67FFAD233D8F1" modified="2019-01-16" version="1">MVFAMLLVVWAHVKALKPAFMSKTPHFNFITIHYFYIMGMAILGSIMVFPNQSINYIDALFLASGAATQSGLNTVDINLLNTWQQLVLYWLSMMCNPISINTAVVFLRLYWFEKRFQHITRQARLGRRTFSKSRSQARPESRDIGLEEHGVHGRKITVMHDTSRLNGMANDGTLTPGRHSAKGPVSEEKSAKSEESSSRGSASEDQTIVTVPTHQTQITFADNVKRSNGEEDEPLRMPVQRSEAEHIAFLERQRNPGDKKVLRIPGPRDADAGVAPEAVDDTDELRRTISQRSSTFNSTHESLDIGEAHPQAVEPERKRNITIAEPDRPVAEHVVDDAIAAKHTMDVFRFRKPRALTKTKTHEEKDEIYPITSTKSRTHTFQTLRRALTSDKDESMPYLSWEPTVGRNSAFVDLTEEQREELGGIEYRSLKSLAMILVTYFWGFSIFGVVCLTPWIYTQTKYGDIVRADGQGRAWWGIFSANSAFTDLGFTLTPDSMISFNTAIWPLLLMSFLIIIGNTGFPIMLRIIIWVTSKWVPKESGIWEELKFLLDHPRRCFTLLFPSTATWWLLWILILLNGLDLLFFIILDLGNAAVTQFPVHVRLLDGWFQAVSTRTAGFGVINLANLHPAIQVSYLIMMYISVLPIAISVRRTNVYEEKSLGIYGSSAEEIEDEGEPSYVGAHLRRQLSFDLWFIFAGFFIISISEGKQIQNDPSFTMFNVLFEIVSAYGTVGLSLGYPTINASFSAKFGVIAKLVIIAMQIRGRHRGLPYELDRAILLPSENLHQKETEDAEARTKRRASTANLDGDENAPYASGALRDHRRSMSASHKQGKAQNLLGTLLHPGPTIPNQFRHHKPTPSTDSQMIRRNSMTPVRGRDTRSISPSARAALSSTPEGRDRRSSKASGRRSFYQEGVNPPPPKDTTISGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9J2</accession>
    <name>A0A3D8T9J2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nuclear pore complex component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_00968</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9J2"/>
    <dbReference type="OrthoDB" id="429932at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005640">
        <property type="term" value="C:nuclear outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070762">
        <property type="term" value="C:nuclear pore transmembrane ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030474">
        <property type="term" value="P:spindle pole body duplication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012578">
        <property type="entry name" value="Nucl_pore_cmplx"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28003">
        <property type="entry name" value="NUCLEOPORIN POM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28003:SF1">
        <property type="entry name" value="NUCLEOPORIN POM34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08058">
        <property type="entry name" value="NPCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW95205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="264" mass="28102" checksum="E9B777FAA16BBD26" modified="2019-01-16" version="1">MSTPKQPSTPSGKSSTPATPLTGTWRHPQFDEIARRQNASTFTDRNFRKVMYNVGGLVVLYLVESSLATSFPRSYHAAFDFLNPYSTYSRWLLQLIFITNIAVASMPLLRKKDDLSDIALTPAQRQLLGLPPSSAPPTPGSQYITPPRYQRTPTPLSGSAGSRGSYSDSPLSRKGSPTGSLQGSSFSPGPSPLLQKAMGGGINGARRSSYGSASPLGPGASRSSFGEVPGSPSPSGAKVPSVGLNQKWLFDKSRRGSGSSRLYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9N8</accession>
    <name>A0A3D8T9N8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative glycosyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_00904</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9N8"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000004">
        <property type="entry name" value="Glycosyltransferase family 32 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF8">
        <property type="entry name" value="TRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14040)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW95141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="398" mass="45260" checksum="7917846A9DACBE8E" modified="2019-01-16" version="1">MPLGGRLTRQIQRALPVYAVIIFVVSFISFHESVSSSLKSADLWKRDFHSKSSSKALGDSFPKKIWQTWKVDPLAFEERDLMSAKTWTAKNPGYRYEVLTDGNDMHYVETHFGPNALNRPDIVYIYRTLTARIIKADILRYLIMYIEGGLYVDIDVEALKPVERFIPDRYVEKDIDMVIGVEIDQPHFVNHTILGPKSQSFCQWTFMCKPRLPVMLKLVDNIIKWLNEVAQKQNVPISEIVLDFDEVIVGTGPSAFTNAVLAELSARNGQKVTWDTFHNMAESKLVGGVLVLTVEAFAAGQGHSDSGNHNARTALVKHHYHASNWPNRHPRYNHPVYGEVEKCNWDVECVALWDISKWEFENLPEEEQARLIAEKQAAIAAEQAQANQDQAPMQIPPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q571</accession>
    <name>A0A3D8Q571_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_13033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000024">
        <property type="protein sequence ID" value="RDW56966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q571"/>
    <dbReference type="OrthoDB" id="14970at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051750">
        <property type="term" value="F:delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045002">
        <property type="entry name" value="Ech1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149:SF1">
        <property type="entry name" value="DELTA(3,5)-DELTA(2,4)-DIENOYL-COA ISOMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43149">
        <property type="entry name" value="ENOYL-COA HYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW56966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="235" mass="26174" checksum="F077A0D4FCCCB8BF" modified="2019-01-16" version="1">MVEFELVPDTTKASLYITFPELDYVVIELNSLVSQDGYTDAICSRLRELFCLFSKDPLVRAVLISIDTTTELDTFNPMALWVPELNPDPNTGKQGSDFMLEAIRNCSKPIICVNHGKMSRTNLQIASASSIRICTSDSRFCIRDDEQVDNKLVDVLQEILQTTENKSLLRQFVLTGKPFPADVAKQLGFVSGVWKTKSEALDEGRRLAKAIAERRVDVVQKLAAEMKGSGKPGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q671</accession>
    <name>A0A3D8Q671_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7068 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q671"/>
    <dbReference type="OrthoDB" id="427518at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055496">
        <property type="entry name" value="DUF7068"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46312:SF2">
        <property type="entry name" value="NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23238">
        <property type="entry name" value="DUF7068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7068" evidence="1">
        <location>
            <begin position="48"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF23238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW57312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="316" mass="35873" checksum="C7E533013F2C24EC" modified="2019-01-16" version="1">MSRPYAKLPFKADLELETIGFDTGQVDDYVNMAFTNPKTMVLDQEGASAVRSFLIGHQHIQDLMRIPIQLDAFCFTWDASKSSPAQLDTMTAVYQAMDLRLWKKDILRLEKTGERQLITSSHLETSTQSTIEGFVSKEISFLEALAFTGLYSYVIEFESAYLDRIKPRINFPDKVLPKLSFLQTSNSAPSSRSHHFLHLTYQEYFAVRYFVRPRPRVSPIIMEAVASSLGNNSSRGLKTAALSLFEHYHEDLVVTALAEYPAKTQSDTAQYKKEEAVVEQGKMGYVLLLIGQSIHNSGHVWFVERFYYHGNSKCGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q6R2</accession>
    <name>A0A3D8Q6R2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative transketolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_12827</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the transketolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q6R2"/>
    <dbReference type="OrthoDB" id="10267175at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051157">
        <property type="entry name" value="PDH/Transketolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005474">
        <property type="entry name" value="Transketolase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43825">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43825:SF1">
        <property type="entry name" value="TRANSKETOLASE-LIKE PYRIMIDINE-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00456">
        <property type="entry name" value="Transketolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transketolase N-terminal" evidence="6">
        <location>
            <begin position="95"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="7">
        <location>
            <begin position="340"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Transketolase C-terminal" evidence="8">
        <location>
            <begin position="522"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW57377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="638" mass="69216" checksum="9E9778662743C496" modified="2019-01-16" version="1">MASATADFGIDVFAKYKPVSLDPENPKLSEQAKSDLLANISLLRDTIVYFTASGAARGVSGHTGGPYDTIPEVCILLAFFEHSVEKFVPIVYDESGHRVATQYLLSALHKHIPFEHLLHYREANSKLPGHPELGLTPGIQFSSGRLGHLWAFVNGVCLANPEKTVFLLGSDGSQQEGDDAEAARLAVAQGLNIKLLIDDNDVTIAGHPSEYLKGYSLGATLGGHGLKVFETAGEDIDQLYASICGAVAYPGPAAVISKRKMAPGIKGLEGTTHAHDVIPVKIAVEYLEERGYNEAAAKLKAITPNSLAYLYSGSSTEKFANRVIFGEAVVTVLEALSKEEAKRRVLVVDSDLEGSTGLSVIHKKRPEVFLSSGIMERGNFSAAAGFGSTKDKVGVFSTFSAFCEMIISELTMARLNFANVLCHFSHSGVDEMADNTCHFGLNTFFADNALIDGDTTRIYFPADANQMRACVSKVFWDQGIRLVLSTRAKCPLIYKENSQDPYYEEGYEFTPSKDEFIRVGTAGYVVAFGEMVYRALDAVDRLRSEGVDVGLVNKSTLNVVDEEAIKNFGSSPFVLVVESLNQKTGLGSKMGTWLLERQLTPKYKYIGTTKEGCGGLGEQIFHQGLDPQSVVKAIRSLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q6T2</accession>
    <name>A0A3D8Q6T2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_12820</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q6T2"/>
    <dbReference type="OrthoDB" id="196103at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010291">
        <property type="entry name" value="Ion_channel_UNC-93"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051617">
        <property type="entry name" value="UNC-93-like_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294">
        <property type="entry name" value="ET TRANSLATION PRODUCT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23294:SF59">
        <property type="entry name" value="UNC93-LIKE PROTEIN C922.05C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05978">
        <property type="entry name" value="UNC-93"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017624001" evidence="7">
        <location>
            <begin position="20"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="320"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="389"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="437"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW57370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="462" mass="50405" checksum="8498E9C0FD4345A5" modified="2019-01-16" version="1">MCLFCLPGIYLALTGLGAGGGKPSSQTVAANVNAILYGIFFVTGWFSGTTLNLLGPKWTIFMGAIGYSLYTGGLWYFDRSGNSWLAYLGGAVEGVSAAFLWASAGFVAYSYAEEKDKALYITIQWCLTEGGSTIAALVALGINMNAADSSGGAPTPVYVVFIVIQVFAMLIALTCLVHPSKVTRSDGTRIAIFKQPTFSEEIRGVAALFTDWKFMMLLPAIFVAEMALALESSVNGYFFNLRTRSLNNLMFNFIQIPASIGMTWILDSRRFGRRRTRALVGITVMSAITLGICSAEAAWLSQKKINRNETGPSTDWKDSAFAGAFVIYVIYGSVYSIYQIATQYVICSLTNDPSILARYAGVFRGVTALGMMFSFIIDGNGGTYICQLSFQFACYFVGIVFLYVAAIYFITDTNYFKEDTVIVPIHVREELAVDALEADEERGPKSDPGFENKAESESKGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q7I6</accession>
    <name>A0A3D8Q7I6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_12584</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q7I6"/>
    <dbReference type="OrthoDB" id="4114509at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW57783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="473" mass="53196" checksum="41231EF580C66A7D" modified="2019-01-16" version="1">MEVSNKTDIVVDYLVVGAGASGLSFVDELLTRTSASILIVDKRDRPGGHWVDSYPYVRLHQPANQYGVESKELSNGRIDERGLNKGLSDLASGVEIEAYFHTLMRDTFLPSGRVTFLPSTEFLPDGTLRRGPSGQILTVQIKKRLVDASYYTNVIPLNHMRPFAVENVTCTPPNHLPNVAKDFTNFTVLGAGKTAMDTCLWLLEQDVDPARIRWIIPADYWFFNRANIQGSLEFFEESIDGFAGMFESISEARNASDFTLGCERAGVWMRLDPTIEPKQFHAATLAPREVEELRRIQDIVRKGHVTKIEAHQITLTHGIVEAKPDSLYIDCTASCLPNKPSVPVFQPGKIVLQMVRYPLIPFSCAKIAFLESLAMQDEERNTFTTPIRFTKNIDGFIPAFGINLENTAREKQHPLLQNWLWQSRLDTFNRLEAAIKPEDTEKLAQLGRLQTSFMAAYSNMPKLMSSLESSATY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q8D8</accession>
    <name>A0A3D8Q8D8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">LijB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_12505</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LovG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q8D8"/>
    <dbReference type="OrthoDB" id="414698at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF3">
        <property type="entry name" value="ESTERASE DBAE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW57704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="282" mass="31016" checksum="E230642C52A8E6CD" modified="2019-01-16" version="1">MIRSTVRPDGASATDSILHLPRILCLHGGGTNSRIFRAQCRIIRRHLENSFRLVFSDAPYLSKPGPDVTSVYADWGPFRSWMKPQPGAANYPFSTPPHRANDVLMPVHEADANEVINAIDESLAATMKADDEAGATGEWVGLLGFSQGAKLAASLLLREQYQMELAGLSYQSPSRPSPGPKFRFAVLLAGRGPLVTLNPDFQAFFGREEDIQEAILRLPTVHVHGLQDEGLAFHRDLRDRCCVGESTTTVEWDGNHRVPIKEPDVAAVVKALVIAYQHSRAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q941</accession>
    <name>A0A3D8Q941_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12285</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q941"/>
    <dbReference type="OrthoDB" id="5428890at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW58355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="262" mass="30039" checksum="BE532C5B4A28969C" modified="2019-01-16" version="1">MRNGLSREEIEMNLSQKFPGHGSKDVLSNSIDLVVRLILMLDVGELRNAYSGRNRLIWKDGLLQDYVRHVFSDNVSLIHDGIKLGTMFTARSLDQVAGFGVNLTTNLADHLRLRHEDRAVTIFHHASFLQCQLQQSILSPELVEETLNTLALLFPVGDSGTKKWYHKQNEPEELDPGVLNCGRHRGDDYRQIGKYRFWHDRLVILKEAFDESQPNNVSQLWNDRREGSQWYGLWVAIGITLFFGLVQSIEGAMQVYKAYQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q9D0</accession>
    <name>A0A3D8Q9D0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q9D0"/>
    <dbReference type="OrthoDB" id="5296at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF1">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW58270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="227" mass="24000" checksum="E38D145AC0839FB6" modified="2019-01-16" version="1">MASCLITGCSRGLGLELTKQLSSQPAVDSSNGRINFVLLDVAKEDSIAAAVLEVTQILGAGNGLDLLINNAGIQILEQNGVTGLHALTESFDVNVIAVHNVSVGFLPLLSSSRQKKLVIITSELGSITNTAIFSTAPFPSYKVSKAAVNMLMAQYAMELGPKGFTVFAINPGWLSTDMGGSQANLEPVVGACQVVEIIQKATPADNGSFRQIYVEGWDVYDGKNIPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q9I8</accession>
    <name>A0A3D8Q9I8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_12416</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q9I8"/>
    <dbReference type="OrthoDB" id="3477286at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="220"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW58486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="789" mass="89366" checksum="0AC01D80BD86E914" modified="2019-01-16" version="1">MADHSIDPRLLREAPSPELGHDAEPRDEAGADDGDSASEPEAEGHDGRQKRQKLNLWKCKQCRDARRKCFPVGRVWPQKCERCLQHRPELPCSQPELNSRKRGPNITKPARRVRTRLASEVTEPQSRDKENESSAEETFTYDRPVRLVKRFKREPRMVEPSSPSLQPAHDGKPNPSQVAFPYLELQQDEFRLLQLAPGKKDDAKLVGSFLTASVHDPPAYEAISYVWGGNEGAEVSPDVIELQDAASPPQVHTYYLRSNIHAALRALRRLHEPQLFWIDALCINRSGNMPEVNQQVTMKREIFHKSKNVCFWLGEEANSKAALDFIPRMLDVAVIDDIIRDTSTRTAEGWSAFVALLKNRAFSRLWFVQEVAVARNVTIHCGEQAIHYADFVDAVTMFSSRRNDICRHQPKLYGDLNDRRIAMAERFVDVTSNALRWPKGSNVSERLLSLEDLVSQLSDFTSSNPKDRIFAVLALAKDGLPWFEDGQAPAHETRNPPSIEINYDRSLQDIYEGFFAHVVKNSESLNIICQRWSNSVPENAEQLPTWVRPLHSFNQLHTEDMTSGRIDADVLVGLPGKSFYDASKGHRASKQLQINDQYLIKHIIVDGFPLDEITGLGPRALEGIISYEWLELGGCVLSDEVDPIPERFWRTLVADRGLNGSHAPSWYHLAFLHCLERSTPTGDIETKRIIEDCGQGYSFVVEFLRRVQSVIWNRKFLVTKDNRIGLAPMAAREGDVICILYGCTVPVVLRPSDGSRTHWSVIGECYLHGMMDGEAIERHQGGPVRLELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q9J8</accession>
    <name>A0A3D8Q9J8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nitrilotriacetate monooxygenase component A IIA synthase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_12426</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q9J8"/>
    <dbReference type="OrthoDB" id="5561043at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF16">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="7">
        <location>
            <begin position="41"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="479"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW58496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="520" mass="57949" checksum="C9ADE56F34CEDA85" modified="2019-01-16" version="1">MVQPSETALRGKRHMHINFAETACAGSHMGIGQWKRPGDMTRFKDRLDYYVWMAKTAERGKVTAIFFADTYGFFDTFMGSPDPQLRAGTHTGQIDPVTIVGAMAQATKSVGFALTGSTTYLRPFILARTWGSLDHVTDGRIGWNVVTSFGETTAKQMGYKEQMSHDERYEAAHEFMDIVYQLWEKCWEDGVQQWSVEPEMAYDPSKFNKITFDGKYHQFEGYGQTHPSPQRTPVLFQAGNSTAGIDFAGKHAEAIYCGSPKIPGLKEYSKKVRAAAVAHGRDPYDIKLFASMTPIIGRTVEEAEAKKKEYWENSSWQGGLAHFCGYSGIDLSNAPLDEPFDFDGGDLNKAQIQGFVKAFRTIAGDRSWTPREIGKAFAFGALVPKPTGTPEMVADMMEEWFYECDVDGFNLSYFSNPDSFEDIVDLLVPELQKRGIYWDDYPVPGGTFRENMHQVPGEPNIPLRHPGAVHKYNYEELKAKDASKEPTDTAAAGESVASEPVADAKQNTTEPKVAEITVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QDS1</accession>
    <name>A0A3D8QDS1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein O-GlcNAc transferase</fullName>
            <ecNumber evidence="3">2.4.1.255</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_11581</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.255" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW59975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="421121at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000180">
        <property type="entry name" value="Related to UDP-N-acetylglucosaminyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000552">
        <property type="entry name" value="UDP-N-acetylglucosaminyltransferase (AFU_orthologue AFUA_1G03380)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11380:FF:000004">
        <property type="entry name" value="UDP-N-acetylglucosaminyltransferase (AFU_orthologue AFUA_1G03380)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000110">
        <property type="entry name" value="UDP-N-acetylglucosaminyltransferase protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029489">
        <property type="entry name" value="OGT/SEC/SPY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44998">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44998:SF1">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE 110 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13844">
        <property type="entry name" value="Glyco_transf_41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13374">
        <property type="entry name" value="TPR_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 8" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="543"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="902"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="936"/>
            <end position="969"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="10">
        <location>
            <begin position="1136"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="10">
        <location>
            <begin position="1393"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="65"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="371"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="611"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="76"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="315"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="371"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF13844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW59975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1620" mass="179947" checksum="E32AE5E4252E738E" modified="2019-01-16" version="1">MSNMIPQIANHNQRPAYLEYNTRLDESLHAPAAGAHPEALLPYSSQHPDTPSSSLRQQGFLNELPDVPRWGHMSDGRSSQALTSQYDDPGEHMLRRKTPNGTLAAGYNGEGRAAMKHIVLPLSGSSQDHTHSSDLYLQGRDSSDIEWIHREPRFESRPAVDGDMQSNNTTWANGTYLPSFGNQVQHMPGQTISNHGPALFGYNGMQIPTVLQPAWQPSPGPTASNDGGLYGPYWPDGRYVPYRPAAFQDHGRYGLNHYWGGGRDQQESYPGAFSAHRSFTHNIDSTPREPPMFAVPPKFNLTRVDSGYGTTQNLSINSNVQYTPDGNEGRTPTGYSNFNRANNAHFKERTLSWAHSIYVELLAFLHQSKKDPRHLKPHGSRSHSKNSIFPKPPRQPYPHFDSSTWAANRRTEQSQSGHAINVSGHGSPARDATARSDTASTYSGDSFAQWPGTGEPAARRQSYVATQVTPHYMSPFQSVNISTGSPSSKARDALEILTTLCEQSEWCWIDGMLLGGCLAYGLEEYQKALDWYSKIIVIDPKHVEAMSNLAATLLCLGRREEAEQYWLQSVKLRPSYFEAVEHVIGLLCGDQRGYEAVGIIEFVEKSLRLPGREESHELTSETSSSTDHDSCGSFSSEYTASDYDYGLSSQAQARNGLPDLSHPGFGSSGFAIPGSENGRILALVHAKGNMLYALGHTGRAAKAFEDAVLISAGTRQHGIQGLIRRITHVLSFDSWAKLRTGYETAASPGTSSPLLLPPDKALQTARLVFPKNGSLPGLCHVPEGVARRAAISTTSNSLLSLAKIFQDAMSKTNSSQKFTMMPSGIGDILALYYLSLSLQPSPSTANNVGILLASVQQPASTRPITQQGNFIQSTIPGVVPGSGVALALAYYNYGLNLDAKHAHLYTNLGSLLKDIGQLTAAIKMYEQAVACDSTFDIALANLANAVKDQGRTSDAIEYYRRAVASSPDFAEAVCGLANALNSVCDWAGRGGVILDGGKRDRWHVDESGMITEARSNGSGSGWMKRVVDIVEKQLKDGCNWGRGTLNDQSLPKFLLQLEAAESGAKWSVDRRTSMHTALRAWCGHPWEGARLTRLVERATKIATHRWYQDKYISKINFPGSCYPRPEFPSSLSVPSAPTVLPFHTFTCPLSAKDIRKISQRNALRISCSTLKAPWMPECAFAPPSPPAPQLNIGYVSSDFNNHPLAHLMQSVFGFHNPLRAKAFCYALTASDRSVHRQQIEREAPVFRDVHDWPAERLVKQIVQDNIHILVNLNGYTRGARNEVFAARPAPIQMSFMGFAGTLGAEWCDYILADETAIPPETLRPWRRNIDLQDQILDEEACEEEGWVYSENIIFCRDTFFCCDHAQSESPESRMSWEDEQTKRWRMRKNLFPNLSDDAIILGNFNQLYKIEPTTFRTWLRILDKVPKAILWLLRFPDLGESNLKRTAQEWAGESVASRIWFTDVAPKHQHISRARVCDLFLDTPECNAHTTAADILWSSTPLLTLPRYKYKMCSRMAASILKGALPRNEDGKQAASELIAKDDQQYEEFAIRLATGFSYEAHPSGRGEGVGRLGELRKLLFDSRWTCALFDTRRWVRDLEDAYEEAWRRWVDNEGGDIYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QE72</accession>
    <name>A0A3D8QE72_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_11633</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QE72"/>
    <dbReference type="OrthoDB" id="10325670at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW60027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="588" mass="64960" checksum="DB95770E10D3B738" modified="2019-01-16" version="1">MNLDGVGGARQAGVHSAESKQVYLNNEKRLRLNWGIEKDQPWESKFPIEIRPGYGDNKPLGLTALTFLSQISSLVSCDEGVRLMIDECRDEKGRPIGMGWKHTKTIANALKESTQNTQTTSKESRRRTKSLDVDEPAATGAADWGSRKAAKDMPWKPIKLSSKLSAMEPNETPGRGEMSSSVRTSLPVSFNTPLAPMSIPTSPPSTSDKVTGYSASRRRAVPRTPKFPKISPKSAKNPPSHSIIVSRESPTSSLRQTENNDKPVTTERKRDLLTRPAELFSSEPPTKRTRIDTIIIQASQSPNTTSVSSTEAAPKVQEISAFPEAPIHAAPPVQEVSAASPQIDTDHQSPLSMLSSSSSSPVALSSPTSSVSPSIEVEPFGIQELGERATTWSPKSKVNENQSVEAEPTKTVAAATTPPLPYIRANARIIGTPASDFQAVEGDTTQSDEWEKQATVVREQLKDLDKRKPMKAWPGAIREPVPGKPIQPYGFYRNTATMQQCWLQLKENERMKELRLQDIDEANRALNWPRSLEIWCYGRMKDYEELFGGKKLKEITHPADDKKLELVQELMSKVGKQLKDGIEDIFKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QHZ8</accession>
    <name>A0A3D8QHZ8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MOSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_11291</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QHZ8"/>
    <dbReference type="OrthoDB" id="17255at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030151">
        <property type="term" value="F:molybdenum ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005302">
        <property type="entry name" value="MoCF_Sase_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03473">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141673">
        <property type="entry name" value="MOSC N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51340">
        <property type="entry name" value="MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MOSC" evidence="1">
        <location>
            <begin position="132"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW61399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="319" mass="35317" checksum="0903720E42D80798" modified="2019-01-16" version="1">MLIGSQLTMALFGTFLETNPKTAESKGSSLVITFIPPQSNADPKLEWTGSPDQIRFPVQPDTEKKTVVDVNLHGSPTKAYDMGSDINDWFSERFGYEVMLVHIGKENSRAVFGSLAPSNPEAAHKSLRMRLSAMVSSFVPRFRPEGERLAFNDLGQYLVVTQSSTDEVSSRFASGIAMDVTKFRPNIVLSGPVPAFDEDFWAELTITPSSQHSSPRNAKARNVKMQLTGNCFRCQSITVDYKTGQTAADESGLVWKKLNKDRRVDKGAKWSPVFGRYGFCARSDVGVTLSVGDEVKVTRRNVERTIFDWPGLTTFGLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QL84</accession>
    <name>A0A3D8QL84_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_10809</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QL84"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF237">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ATNE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW62507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="522" mass="58093" checksum="D1FBE4420B6A9F52" modified="2019-01-16" version="1">MGSLPMAAIQPQQVVLSLLTVGVLSLLSFAVYRLTFHPLAKYPGPVLAKLTSFYKVYHAYIGDMHLDVERCHKKYGPFVRYGPDNLLVNTVEGFHDIYGTGKKIKKGPSYVMHGPGNLIGVRDKKYFARLKRIFSQGFSDSALRDHEPKVRKQIDIFCNRMEDEQALEKGSSGWTLAKNMSKWCNYLTTDVVNMVVFSTSWDLLTSPKNRGVSESLATAVRMVGITHQTRWLYQFKLGPVLFPHLIGSILGLRKHTLSILGESKKAREENPDIKDVFAQFINAEDPATGTVLSADTVRLNSGTLIIAGSDTTSSSLAGTFFYLARDPEAYAKVVNEVRSTFPTPASIRAGAELNSCVYLRGAINEALRMSPVVIQPLWREVESPGASIGGQFIPAGMVVGSGIYSLHHDPVVFPDPYRYDIERWVVGTPEEMKTRQHHFAPFSVGPRQCLAKNFAMMEMLLTMANVVTRMDFKLPEGDAAKVGGGGKGQGWAREREGEFQMKSWFTSHVNGPMITFKKRQLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLH5</accession>
    <name>A0A3D8QLH5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endoplasmic reticulum-Golgi intermediate compartment protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_10954</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a role in transport between endoplasmic reticulum and Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Golgi apparatus membrane</location>
            <topology evidence="5">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ERGIC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLH5"/>
    <dbReference type="OrthoDB" id="5541786at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF81">
        <property type="entry name" value="ER-DERIVED VESICLES PROTEIN ERV41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="7">
        <location>
            <begin position="23"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="6">
        <location>
            <begin position="190"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU369013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW62652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="376" mass="42162" checksum="86541DCFFAFC93F3" modified="2019-01-16" version="1">MNGFEAHGLDEDAFGEKPGNIVQAFDYFPKAKPQYITKTSGGGKWTVAMITVSALLIFSEFRVWWQGQEEHTFAVEKGVGHSMQLNMDIVVAMQCQDIHINVQDAAGDRILAADILKRDPTNWGQWVDNRGVHKLGHDAHGRIVTGEGWHNLEHDDGFGEEHVHDILAAAGSGKKAKFGKTPRVRGAGRGDSCRIYGSFFVNKVQGDFHITARGHGYQEMGQHLDHNAFNFSHIVNELSFGLFYPSLLNPLDKTIATTPNHFHKFQYFLSVVPTIYSAGRDIFTNQYAVTEQSHMVGDRSVPGIFFKYDIEPMLLTIEERRDGFLRFVVKVVNVFSGVLVAGHWGFTLTEWAMSVWGRRRRSYSDGVLTGKASLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLU6</accession>
    <name>A0A3D8QLU6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Homoserine acetyltransferase like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_11039</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. MetX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLU6"/>
    <dbReference type="OrthoDB" id="9972683at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008220">
        <property type="entry name" value="HAT_MetX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268:SF15">
        <property type="entry name" value="HOMOSERINE ACETYLTRANSFERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G15350)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32268">
        <property type="entry name" value="HOMOSERINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="67"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW62737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="343" mass="37435" checksum="59CB76541C1DD251" modified="2019-01-16" version="1">MSSKAPYDATGIEYFDIPDFQFSNGHRQPIKLAYRSFNPAGTKGTVLIPTCYGGRINTTLNFSTGALQDYQVIVVAMLGNGESSSPSNDPAFPLTKPGPSVQYEDDVHAQYQLVTERFGLQHLEAVMGFSMGGQQAYYWSVMHGSGPAPFLKNAVVICSSAKTSGHNYAFLEGPISALEAAGDYAGGAYRAQGSKPREGLRAFGRAYAGWLTSAEWYRQELWRKLGAASLKDYLHPEVANYESWDAEDLLALARKWQAGDVGKVGGGGEGYEKALQGIQARVLVMPSMTDQYFSWRDSEREMEHLQNGVFRPIDTIWGHIAGGGANPADAKWMDGEIATFLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQA7</accession>
    <name>A0A3D8QQA7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dipeptidyl-peptidase V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_10508</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S9C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQA7"/>
    <dbReference type="OrthoDB" id="416344at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000028">
        <property type="entry name" value="S9 family peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011659">
        <property type="entry name" value="WD40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776:SF13">
        <property type="entry name" value="DIPEPTIDYL-PEPTIDASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07676">
        <property type="entry name" value="PD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="7">
        <location>
            <begin position="485"/>
            <end position="694"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW64006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="710" mass="78372" checksum="3245BA07C30C33C9" modified="2019-01-16" version="1">MTVRAHKFTPEVLLSAPRRSAASPNSTGTLALYTESVYSFQSHSKTSEICVLDTSNGQSTCLSSDLNASEPTWLGDKDLVLWLKSGDKGITNLILGDASSPHSKPETIATFDGGVSNIKVKSLDDTTVAFVVSGLCTPDGQLYNSETAEKPRSTAKVYSKLFVRQWDAYVTENKNTLWYSTLNKSSGKWTLNSTGLINALGGHPVKLESPVPPFGGTGDFDISAFGIAFVAKDPKLDPANYTKTDLYYIPTRTFAETKPSSAQIIKTGNLRGYSQSPTFAPNGKSLAFTRMKSDQYESDKPRLLLVPDIGDLSNVQEFFMTDDGEGGWDLRPESIVWSDDGETLYVTAEENGRGKLFSLPSSPRHATKLPTALTSRGTVADAKYLADGKFKGNLFISSSSLVDNSNYTILDPAKPAEVTPISSTSKGGRMFGLHQNQVDEFWYTGAGDYKVHAWVVKPSNFDKAKKYPLAYLIHGGPQGAWNEGWSTRWNPAIFAEQGYVVVTPNPTGSTGYGMALQNGIQNQWGGRPYEDLVKGFEYVESNLPYVDTSRAVALGASYGGFMVNWIQGHPLGRKFKALVTHDGVFSTLNQYSSEELFFPHHDFSGTLWDNRENYEKWDPAAHVKNWATPHLIIHNELDYRLPIAEGLAPFNVLQTKGIPSKFLTFPDENHWVLKPENSLVWHREVIDWINHYSGITEQDSLQQGVSNLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQM0</accession>
    <name>A0A3D8QQM0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AA1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_10470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW63968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQM0"/>
    <dbReference type="OrthoDB" id="3562476at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017629688" description="AA1-like domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW63968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="13247" checksum="0DE4A68A7CFA387E" modified="2019-01-16" version="1">MKTFTATILAIAAATLASAAPASIKRDYGLGSVEVTFLGATDNPQQSYCIEVEISPDADCEATSVAPYDPKSLSISYVDYDHDVATCYFYGVDSDKTNLAESVIDSYHGQLGPPQTILDVLCVPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QR64</accession>
    <name>A0A3D8QR64_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative sorbitol dehydrogenase-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_10769</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QR64"/>
    <dbReference type="OrthoDB" id="5363962at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF25">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="9">
        <location>
            <begin position="10"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW64267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="373" mass="40107" checksum="42199B51698A02D7" modified="2019-01-16" version="1">MSVKASVLHGVKDLRVETREVPELSPTEVRVQIQATGLCGSDLHYFNHYRNGDIIVREPLTLGHESAGTVSAVGSSVTSLKVGDKVALEVGQPCKKCERCAEGRYNICKEMRFRSSAKSFPHFQGTLQEFIHQEAEFCYKLPENVPLEMGAILEPLSVAMHASRRANLAPKSKVLIFGAGAVGLLCAATAKVNGASEVIIADIQGDRVDFAIKNKFADAGIVVPMKRPQTIEDKLAFAKEVAAMASEKFQAGSGTEADAVFECTGVESCFQASIFATRAGGVILAVGMGNPIQTLPISAAMLREIDIRGSFRYSNTYTDAIELVASNNPALPDLSTLISHRFKGLDNIPSAFDMAGRVKDDSGNLVLKVLVEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QRK1</accession>
    <name>A0A3D8QRK1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">T-snare protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_10772</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QRK1"/>
    <dbReference type="OrthoDB" id="421009at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15844">
        <property type="entry name" value="SNARE_syntaxin5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000007">
        <property type="entry name" value="ER-golgi SNARE complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021538">
        <property type="entry name" value="Syntaxin-5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF3">
        <property type="entry name" value="SYNTAXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11416">
        <property type="entry name" value="Syntaxin-5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="230"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="187"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="187"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW64270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="322" mass="35571" checksum="771F0608023AE3AC" modified="2019-01-16" version="1">MAVASIQDRTTEFRSVLAQVQKRQASSKVGAQRQSLLTDAQKAANGGANGDGKPRRSEFARRAAEIGRGIGATMEKLEKLAQLAKRKTLFDDRPVEINELTFIIKQDLSSLNQQISSLQSLSRSQHPKADQEGEHNKNVVFLLQGKLTDVSVNFKDVLEVRTKNIQASRSRTENFVSSVSQHAAPSISQSASPLYSTPTRGSPGPGQDLLSLNPVSDQQLLMMEEAQPQNTYIQQRGEAIEAIERTISELGGIFGQLASMVSEQSEMIQRIDANTEDVVDNVQGAQRELLKYWSRVSGNRWLVAKMFGVLMIFFLLWVLIAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QRL2</accession>
    <name>A0A3D8QRL2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_10636</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QRL2"/>
    <dbReference type="OrthoDB" id="2264294at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF4">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN DAL81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="592"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW64134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="685" mass="76914" checksum="F2424E8BF2B9A9AF" modified="2019-01-16" version="1">MASSHQPRRKERPCDACRKRKSRCVLDGDSTICVLCRFHNQDCTFLQNPQSRKRKPTIELDDLELDAKRRPSASSVRSKKSPGTQGRIIRTTNGTGVEEYDDLDGPSLLKKTLGLQNKHHSRYVGATSSLEPALLGEACLPGVDELQLTGSTLRRVSSKEAFTLLPDPETQGYTDELDDLDAIESIVKPHGKSLIDLYFRIVFPSFPILHKEVYLEKYSRSYREFSPPLLAAVYLLALQYWTYDDRLSSLTKPNVQKLEELARKALRDTIHRPKLSTVQAGLLLLQHTDTDSAELTAQLVSVAYGLGLHLDATDWNIPDWEKGLRKRLGWGLYMQDKWSSMGSGRPPLINSSNWILRAVVDSDFPENAAHEDDQEGSSEVEKGRILFAHMISLSQILAELLENVFTIRAAREIASAGDEGLDIVLGKVKPIQLKLKEWYASLPDCLTMNSTRAMKLSSVGYLRLAYFATEISLHRRILLAVSSKTDPQKASVCRSAAQERFNAAIDFVEKLKPQHLLSFWYFASPHNFALIGMFGTLLRATAPNLEEAEHYRTKLKEYRWTLKLNSENGAKFMRPAMAILDANTDLLENARAKSQSNPSLNDYTTPEQSDGSASTKMEDYSFPLAQFEPGADYSTPGLYSFGTPYYSGQTPDMSATTYAANLNTSTRTRNFTYESSADPSLWTFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QTU0</accession>
    <name>A0A3D8QTU0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_09874</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QTU0"/>
    <dbReference type="OrthoDB" id="5226580at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW65182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="43416" checksum="46B876CA668220ED" modified="2019-01-16" version="1">MGGEKNLDVLQGLLVYILWSNGLAFERPQLNILLGLALALAIELSLFTAPCSFESHEQFLPEMKCIIDCNRSWVRWTETSKEEKRAVLGCLYLFSFASVKFSCWNPLQWTPYIQQCHKDILEDPDSDADIYLAHLLGLQRIADTIKNVSMQSLALDPSSRRTSVAIHVKLLTSELQKFMAALPDKLKQDSLMLVHYHVVETRLFDLGFLMPPTNLVHGPTPQRADLLLLCLSACQKLIKSLLRLDCETIAHFSTSNAANISVAMSILSKLMLFHAEDWDISNVPLEMDLPTFISWAVALLEDGSSRYDRVGSSKQPWLQLSRKIKLVGVRFDGLMTIENNRLFSQTVDQTRDESMATPLDLNTFDLFDDAFWQLLPVGPPLQSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUA8</accession>
    <name>A0A3D8QUA8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_10049</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUA8"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="89"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW65357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="222" mass="25444" checksum="E34FD45B63F6C741" modified="2019-01-16" version="1">MLPITVWGHWAGPNPWKVCMILKELDLTYDYRIVEFVDAKKEPYTSINGIGKLPSILDPNTGMKLSETGAIILYLIGQYDSQGKISYTDLPQKFDCIKWLMYQVSGQGPYFGQLTFFARFHPEKIPAVIDRYTEQVEMVFGVLDKALENREWLVGEKCTYADLSFVTWSHVAKGMLRELGKEVIFKSFPRYTAWFEAMESRQPVRDCLKEIAAGRISHGLPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUM1</accession>
    <name>A0A3D8QUM1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_10080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUM1"/>
    <dbReference type="OrthoDB" id="21266at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070692">
        <property type="term" value="C:CTDK-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032786">
        <property type="term" value="P:positive regulation of DNA-templated transcription, elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000032">
        <property type="entry name" value="CTD kinase subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042326">
        <property type="entry name" value="Ctk3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024637">
        <property type="entry name" value="Ctk3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024638">
        <property type="entry name" value="Ctk3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28291">
        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28291:SF1">
        <property type="entry name" value="CTD KINASE SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12243">
        <property type="entry name" value="CTK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12350">
        <property type="entry name" value="CTK3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="3">
        <location>
            <begin position="51"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW65388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="306" mass="34327" checksum="5EC3C2DE3EEA164A" modified="2019-01-16" version="1">MSGLNKALASSRTASHKRGGASGPGNDNEIPSGPDRGHAPKFAEKANETMDPFEVRIRFTNHLQHLNASVTSSQKAAQYALKYRDMDEDLHSCILEQLERASSNAQEFKTSKLMILCDMASREGHKDYVRMMQRDILRIVDAVTPEDGSGAANVKVVRKVLQGLQTKKYLLGQTVTEIEECLKERDTSSEHLGLSSPLHPDDVEMGGTEGGAVQRSKQVPNGTLRQDKKQVEQRIEEDRERHKRLRENIWAVPSIPGNPNAEFDKLWEETSDLGEDDFILYAEEAAERRKMAEEWKLECIVKGVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUQ8</accession>
    <name>A0A3D8QUQ8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Large ribosomal subunit protein mL60</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_10199</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Component of the mitochondrial large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUQ8"/>
    <dbReference type="OrthoDB" id="2332379at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016340">
        <property type="entry name" value="Ribosomal_mL60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28271">
        <property type="entry name" value="54S RIBOSOMAL PROTEIN L31, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28271:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09784">
        <property type="entry name" value="L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002216">
        <property type="entry name" value="MRPL31_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR002216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW65507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="110" mass="13084" checksum="5F0332B58B0A7BE1" modified="2019-01-16" version="1">MFGAFKPTNSLSGGLLWKIPWRLSKFQKQRQRRRLRAVDTVVSVIDQALAKKGITTKAVERWKDEMPIEQEMLPKDKYTIFDRKEKKYRKGIHKLPKWTRLSQRLNPPGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUR1</accession>
    <name>A0A3D8QUR1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">WSC-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_09926</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017636063" evidence="8">
        <location>
            <begin position="30"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="938"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="1076"/>
            <end position="1168"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="1263"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="9">
        <location>
            <begin position="1462"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1171"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1364"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1171"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1364"/>
            <end position="1446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW65234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1566" mass="161958" checksum="259CE9262123A949" modified="2019-01-16" version="1">MVSPSKVSGILSTSFLLTFSTFFIGHVQSLGATDTITWGGDNSRSGYQDNHNMDPSVVGSGAFGQIFKTQLPGVYNGAAEQLFAQPLVYTPPSDNTQYVYLATTQNNIYKIDAKTGAIVLSRNLHIPFLTADLDGCVDINPLVGSTATGVIDPDTDTWYLTTKTYVNQNGGTGAQGKPNGRYYVHAINVNDLTERPNFPVNLEGTVARNNPIRSFNGGIHHQRPALLHTGQFIYAGFASHCVQYNFTGWIMGWDKTTGATVERYATEGAGVPNTTPGGGVWMSGGGLTSDDAGSMWFASGNGYASQLSTIPVNGRNPPTSLEEAAVHMTINADGSLQIVDFFMPYEKTQLDGADKDLGTSPLELLPSQFACGDYKRIGVVTGKSGKTYWLNMDDLGGYQNGANKLDRVIQVTQNENSVYAGAGVYPLEGGYIYINVIQYPTHVFKFSCTNGVPAFTKVADSPTNNAYTLGVGHGTTTSLNGQVGTGLLWVSDVQGLNLKIYNAVPVNGVLNMINSFNIPGITKFTRPVFGNARVYLGTTTGFFYGFGSPVNQPVNCTGQTNFGTANLNNATAPSTITCLASVQVTVNSLNVNGDANFVVASKPTLPLTVAAGTSFTFTAYFNPKAVGPLSSDVIVNTTNSVAGYSATTPVTLRGNGQSVNALLSISPVTLAFSGVIVGQNVGGSNASVLFTNQGNSPLNITSILYSQTAESGPYIDANSSESGPQVGPFTFINLPTSIPGNAVVTVDVNFNPQYSGNFQAYLKVNSNSGIKYLDVVATAGSAPSAVVEFQTPDGTGWVQYQSGTNFTFGNVTENTTRSLKMRVTNNATTNSASLSLTVSKPPFGVAGIIGANNQVDLAEGTLIPPGGNATATLYCSVPKSQLNVNPYVGTAQWTMNLNDPNFGKQFIQFACGAIAEQAPPTIQSPGSWNGQPLQPQGVYRYVGCFKENNPGRQLKTQFYGNNNNTNEMCIQTCAAAGVAYCGTQYNRECWGGPTIPTLQVDEGNCNFPCTGNINEICGGNGVGANAGGSYISLFALNTTIPAASSTSTTAGSTSTTAAGSAPTAKGGPYVNPGVAGYTSLGCYAEPSTGRALSTQLTGTGNTVAGCLQACSLKSTGQYAGLEYGGECWCGSTLLAGATAASTDCSMVCSGNTTEYCGAGLRLNLYQRSSTSTSSTSTSSLASTSSSSSVSTGTSTSTGLSSVSTGSSSTGSSSTASSSASSSSSSSVTSISTTSSSSSSPSTSTTSSAGPTQTLARKPIVNTVWGRKGCWTEATNSRALTVSTFANDSMTLEACGSFCVGKSMFGVEYGRECYCGNDLKTGSVQATDSDCSFTCPGNKYEYCGAGNRLELYTAISSASTSSSVLTSTSSSVSTTTSTSSSSSSVASTAGSSTSAGSSSSSSSSSSISSSTPTSSSSSSASTSTTLTTSASSSTSSSSTSTSSTSSTFPTYTGPPVITQGNVNFTYYNCSTDTGARVLPVLKEASDLMTVSRCLANCWNYGFAGVEYGRECWCGNTLASTSTNVTDSPKGGQCSFTCPGNSTEYCGAGNRLTLYYFDTAKAALNAGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QVH3</accession>
    <name>A0A3D8QVH3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_10206</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QVH3"/>
    <dbReference type="OrthoDB" id="190201at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF87">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017754293" description="AB hydrolase-1 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="124"/>
            <end position="379"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW65514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="398" mass="41784" checksum="2B4FAB5AFA4584FD" modified="2019-01-16" version="1">MASIHSIFALSVLSIASASAAMHNLTSYGAGFLDPTIIPSAGGFAICIQGDIPVTASAQNVRLNYTEPANQLSVTNTILEYLQANTTLPETVLGTAANISGTYNINSKLCLPSTQTANSTTIQILTHGVAFDKSYWDFYSSDYSYVDAAALAGYTTFSYDRLGNGKSSHPDPIQVVQTPLEKEILHELIQMLRAGSIGATAFENVVGVGHSFGSALTVSNTVDYPEDLDAAVLTGFSIDSSGKPVFVAGLGLDIAANNNPTRFGSLPNGYLISSTVSNNQFGFFRAPNFDPLALWAAEATKQTFALGELFTNSLLGGIATKFTGPIDVVNGENDVPACNGNCLVPTNAAAAVIRALYPAASNSSQYYTAPGTGHGLNLHFTAPVAYQHILNFLAANNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QY74</accession>
    <name>A0A3D8QY74_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Alpha-ketoglutarate dependent xanthine dioxygenase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_09495</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QY74"/>
    <dbReference type="OrthoDB" id="93019at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051178">
        <property type="entry name" value="TfdA_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779:SF2">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT XANTHINE DIOXYGENASE XAN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779">
        <property type="entry name" value="DIOXYGENASE RV0097-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="7">
        <location>
            <begin position="23"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW66746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="396" mass="44610" checksum="E2508105E81420F1" modified="2019-01-16" version="1">MPSAVREIQVEPMVHGPKSNVNFGATVRGIDLNKLTDSDFEIIHKALHQHKLLVFKEQPEMLQPEHQYELTRRFDPDETTGGFAHGTDPYLTSHNGVDIYGLPNRPAIPVQPQVHILGRGPVPDGHYQFPPGFKIKGIDHHYFHLPPHIPVEEREAGKSRFYQWHFDGSLYKIPPPRVGCLLAVRTPKGPDVKVQWDDGTGTEMAIGPGSTAMVAGSRALELLSPEMRALAYHSRIEYAPHCFEWMSTAHSTRLGHTIETEGLEKPLDKLKPWSPEHICTYPMVWENPVTGEHSLQVHGQGAFKLFLKSSADGPEKIVTDLAEVRAFLHNMMRPVLDPSNIYAHRHEEQDVILWYNRALWHSITEFPESYGPRIMHQCNIAASDHPVAAPVPADLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYB0</accession>
    <name>A0A3D8QYB0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransferase-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYB0"/>
    <dbReference type="OrthoDB" id="184880at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW66668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="419" mass="47092" checksum="9D64FBE757F273B6" modified="2019-01-16" version="1">MSTTPQHDDDSAISVVGTSSNQSSMTQASRARNRSSVSPPKSEHSPQQSGWNQLSAAEQAEQNAEGEAAVLQAQNEIDVDSGADAQSVSDAGYETDSIGTTSTSLASSYRNFAFENGRRYHRFREGSYNFPNDDLEQDREDLKHAMMMHLLHGRYHYAPIGPHPGNVLDIGTGTGIWAIEMGDLYPSADILGVDLSPIQPEWVPPNVKFMVDDVESPWLKPLNHFDYVHSRHTVMAIRDWPKLMRSVLDHLKPGGWYEMQEIHHIPYCHDGTMPPDHPVCQYWHLITEALAKLNVNFNATLLLEGIMRDSGFVNVHTRIFHVPIGLWPRNKVLKKVGLYWRTVLIDGLEPIALAPLTRGLGWSKEQVEVWLIEVRKAYMDSWVHSHMPLYITCGQKPGPGVYVYRTGEIPPWADVPIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYJ8</accession>
    <name>A0A3D8QYJ8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYJ8"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW66847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="160" mass="17982" checksum="91109FF91F165C9F" modified="2019-01-16" version="1">MEEEIGSVNDRYGSILSQEQHALFGGLYLKTDERDNDSVPALESYIVNPCASIPISGYDHKFEDECEDENEDNNEDFQSEAGEPSSGSSQGSVATGDKLGVWPQRLLRVDNMKSYEWQPGNIYGGEVAPKYNAISYTWGRYDIDSPFAEHKANKRVMRKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYN2</accession>
    <name>A0A3D8QYN2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09636</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYN2"/>
    <dbReference type="OrthoDB" id="40334at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032801">
        <property type="entry name" value="PXL2A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42336:SF2">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42336">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13911">
        <property type="entry name" value="AhpC-TSA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW66887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="246" mass="26979" checksum="5D7DFB2A930E7442" modified="2019-01-16" version="1">MFSSLTTKLALRKVGLSTKDFSFPSEPTGKAGKQDPDNASPFPNPFATIALPKSLLSWQTPPPPPVELGVPPVWGTRAPTSSKLRLPGQDGRPTVVVFMRNTGCPLVHEVAEKTFIEMRRLANKYPDLSFLAVSHASKAATDRWVSSIGGAWAVQIIIDEEREVYAQWGLGISNTWYVLSPWTQWTQYKLGKEEGVWGREVDPSGNHWQIGGSWACDVMGTVRWGAASKSADEIPDLIEACKSLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R2X8</accession>
    <name>A0A3D8R2X8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_09060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R2X8"/>
    <dbReference type="OrthoDB" id="342264at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="13"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="329"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW68403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="352" mass="40313" checksum="4AC6B98AF0B7A229" modified="2019-01-16" version="1">MVRARASRTGRSRSKQIFAGKRMAVAGDFSKLKWNYDQMINWIKGHGAEFAAKVDNNTTHLICTIEEFKLARKSPQVAAALKLGSRQCKIVVGDWLEDCLIGGKRARLLNEKPYTLDRVLLRIKNAKKEMILHKQKFDDGIRSCKQLVDNNLYQVYYDSTGFQYKVVLTRLSFDGRIDKNKLEKYTLYLYQSLANQPYLYMCGAMLSRPHRPNIYYREDCHPKYFHEAFADFKKFFERKTGVAWDDRLEGKKAGDDKFVWTPPPLGRPVGLLPEGYIRPRYREENRSATKSSAEENSDEGLIYDTESEVGGSDDEVVYMGASRLSCSHDRSFRSAASQTPSGISHAQSHSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R356</accession>
    <name>A0A3D8R356_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Succinyl-CoA:3-ketoacid-coenzyme A transferase-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_08901</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R356"/>
    <dbReference type="OrthoDB" id="1933379at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:succinyl-CoA:3-oxo-acid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004164">
        <property type="entry name" value="CoA_transf_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707:SF58">
        <property type="entry name" value="SUCCINYL-COA:3-KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01274">
        <property type="entry name" value="COA_TRANSF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW68244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="406" mass="44320" checksum="0F882E20D98475F0" modified="2019-01-16" version="1">MKLLWMTRVSDLRHIGILRSFSTAARRQAINKIVASAQEAIKDMKSSTTLLVGGFGFSGVPDTLINALRDRKDLKDFTVVSNNAGMPGVGLGQLLESKQISKMIASYVGENKTFERMYISGELCLELTPQGTMAEKCAAGAAGVPAFYTPAAYGTIVQTGDLPLKHNSDGSVAVMSKPKETRIFNNKEYVMEESIMGDYAFVRVHKADRLGNCQFRKAQNNFNEAMGKNAAFTIVEADQIVEVGEIAPEDIHIPGIYVKKVIQAREKKGIEKLTFDKEGNEESPVSESHKRRLRIIKRAAKELKDGMYVNLGIGIPLATPAYLEPGVEVILQSENGILGMGRHPKPGEEDPDLINPGKETVTLNRGASLFGSHESFGMIRSGRINLTMLGGLQVSKYGGIFSGFMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7P7</accession>
    <name>A0A3D8R7P7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08444</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7P7"/>
    <dbReference type="OrthoDB" id="10331842at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW70047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="500" mass="55689" checksum="537A09FEFAF26F86" modified="2019-01-16" version="1">MHNSGAASTRVRVPMRSSQDSQARGSRWSMEMLPARGLDGTEAAEPILSSISSHITVPTINGTCDGADISDEVEPTCVSEAAVDEHSPKSKHPQWITDMFPAFELFDKARIGDAKLLRLFTGQAGNLDALCITKHAFVLLADMEAGLRFPALMNAEQLLKLLVISNNKFKIFIQGWEKPEMHCQHQSLTSWAHKPNEANRLIRRTTPAARRQWRVQRRKAAEYRAPTHPSSDGCAEGSRYPYLFDSGQSKQEQMLFSYLVVMLLGEMWYYFRYFRRLQNWAYASKKSSVPGYEFSNVFLDYLNRLYNDEQDHIKFHPWAGKSLLAGEEEPEARPLSEIYPPPDESTKLQKDCLEKSSQSAAPLPPDICPSSLVRSLLGEIVESVGTSCVLAPTASWLSFSDLGSYRQVQEPAASSISSGEGTSETLERRRSAVRNARMASKQNSHRVPMRIYGPSAQAGSQAASKPDQPLVNPDKPTTGDHMLEPSSPPKAQGRLRCSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8E9</accession>
    <name>A0A3D8R8E9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">OPT superfamily oligopeptide transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_08716</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8E9"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="139"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="214"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="272"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="342"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="503"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="528"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="617"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="682"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="721"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="757"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW70319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="811" mass="90245" checksum="7E4C6CD4614EA988" modified="2019-01-16" version="1">MTSRIPGAVPAQLSADVNPAFNTGHTTGIEALEELGVHTLPNESSEKGRISVGQYPAKGEVDNQIQDVSAGEDEIPAEKHGMSAADMVDNMEEIALYAIHTDDDPSLNPWTFRMWFLGLGLSAFSSVLATIYQFKPQGIVLSATFLCVISYVLALILEYIPKSGFIGRWFNNQPFNHKEHAAILIMSSTAARSAMAAEVIAVQRLWYSSVPNPAVCIFLIFSSQILGYGIAGLLRKILVYPTKFFYPANLPIMSLLDTLHREKEGNRRRLKVFYIAFALIFVWEVVPEYLMPILTGVSIFCLAKRNSMAFTYIFGGANGNEGLGIGSLCFDFQYIGSSALYLPLMTIGNILIGYVLCCVVFCGVYYGNIWRAQDFPFLSQLLFSPTSNSTTYVTFNQSAVLDSFGRLDEAKLAAEGVPYMAATFASYVLTQNLAITATITHCLLYNWDDLKEAWSFVSLRNLQLLAKPSTWMFWRHEPPSQEQTGDKDPHQLAMQAYKDCPDWWYGLVFLLSGVIGIICIYEANSGMAWWAFIIATLLASFLILFTGAQAGLTGFHVPVQPIIQMIGAYLEPGNPLTNMYFTLFGYNSVGQGLLLLQDLKLGQYAKLSPRCTFTMQMIGTLVGAVLNYVITLSITTNQREILLSIEGTHIWSGAGLQSFNTQAITWGGLAKHMYSWGSTYQWVPLGLVIGFVAPIPIYILHRLFPKMHFDYLNVSIISWHIGWLVTGINSAIVSFFVVAYFSQFYLRRYKPDWFLKFNYVLCAGLDGGTQVVVFIMTFALFGASGKPVTFPNYWGNNGNGNIDFCMVDPRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8F0</accession>
    <name>A0A3D8R8F0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RNA-binding-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_08719</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8F0"/>
    <dbReference type="OrthoDB" id="10259687at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048026">
        <property type="term" value="P:positive regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12334">
        <property type="entry name" value="RRM1_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12335">
        <property type="entry name" value="RRM2_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000121">
        <property type="entry name" value="Splicing factor 3b subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000288">
        <property type="entry name" value="Splicing factor 3b subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034158">
        <property type="entry name" value="SF3B4_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034159">
        <property type="entry name" value="SF3B4_RRM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052084">
        <property type="entry name" value="SF3B4_spliceosome_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030:SF3">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="13"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="101"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="226"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="257"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="316"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW70322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="348" mass="38001" checksum="87CD6686B6ED1041" modified="2019-01-16" version="1">MSGARHWEQDKEATVYIGNIDERVTDSLIWELMLQAGRIVNVHLPKDRVTQTHQGYGFVEFISEEDAEYAARIMNQVRLYGKPIRVNKASADKVKTVEVGAELFIGNLDTMVDEKTLYDTFSRFGSLLAPPKIARDEMNNSKGYGFVSYSNFEASDDAIANMNGQFLMNKDISVQYAYKKDGKGERHGDEAERMLASQAKKHNVMPEMQQMPTQLLMNGGVPQAPAAMLDVPMHPGTPQGIAPPGFARPPNGSYNAVPPPPQRQNAPLPPPPSGLPQRPPPSQAGYGGPQDFHQPGFAPPPGFQNVQMPQGFGPPGGAPPGMPPGFNHMPPPGFPPPQQQGPPGYVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8I2</accession>
    <name>A0A3D8R8I2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">PHD-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_08749</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8I2"/>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045814">
        <property type="term" value="P:negative regulation of gene expression, epigenetic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15502">
        <property type="entry name" value="PHD_Phf1p_Phf2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12628:SF10">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12628">
        <property type="entry name" value="POLYCOMB-LIKE TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="223"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="74"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="196"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="335"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="159"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="335"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="362"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW70352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="481" mass="51259" checksum="46C7811EA2C5449E" modified="2019-01-16" version="1">MDANAQANGAGNSDAPMTDNSPPRPYVQQFSANTAMILQRIKSGVGGLGVGILGQGAAPPPGYEDMKRSVLQGMKTSMNMEIPTPLSAQARRLAKQSPTPTGASRNASGAPSPYTTPYAKKDATAGTSAGGIGSNGRGKRSRAPKAGTKRKRRKSESVSPEESDMPDLDDESDSDGSGSLNMPRMTQSGRQIVKPAAFVPSASSGSARKRGPSKRTQEEKNEQALCKRCGRGHSPQSNMIVFCDGCNLPWHQMCHDPIISDEAVRDETADWYCAECSRKKGILPAFDPTRGVSWQGRSTEQKRAYLQSLSHTQLVSLLLHSTHLYPNIPIFPATASQPTSRTTSQSQERNSTPQQPFPPSVAASSGLFNRADSNPAGTMNFIRKISPIGNTPSPSFPPKDLESSTQKPSAPHALAIGAQAEDGDAEASRESTPASPPYPKPGMGLMAKLGPDDQDDEWLIDNNDFDAFSHVVFEDGDAHAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8M0</accession>
    <name>A0A3D8R8M0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">B-related factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_08792</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8M0"/>
    <dbReference type="OrthoDB" id="511529at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20554">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000002">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000007">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.650">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011665">
        <property type="entry name" value="BRF1_TBP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07741">
        <property type="entry name" value="BRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Cyclin-like" evidence="12">
        <location>
            <begin position="127"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="12">
        <location>
            <begin position="225"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="341"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="471"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="592"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="653"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="592"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="662"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="711"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW70395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="752" mass="83051" checksum="FD258D7209AEF887" modified="2019-01-16" version="1">MPPRPKPAPPRKPNPLKNMRPIVNAPPVIRGGQKAAMVKPKARLCPNKHCETPKIEDGICHNCGTVVDDSNIVSEVQFGESSSGAAVVQGSFVSADQGAAKSLGPAFRRAGGNAGESKEATIRQGKHEIQNMGSQMEIPEPIVTSAVQIFKVCAMHNFIQGRRLDMVGAVCLYSACRKEKPCKVMLIDFADRLQVNVFKLGHCFKALHKTISFAADGIMPIIPEDLIFRFAARLEFGDMTEKVATDAIRMVQRMSLDWMVMGRRPSGVCGACLILAARMNNFRRTVTEVVYIVKVTTNTIQKRLEEFKLTPSSALTVDEFINNEFLESAHDPPSFYQKSEEFLKNKKSKKRKRGVPAEDEDAEEDNAEGSNKRQRDANAGLASPPPTQPSEARKDADGFSIPNPPLRVESVEPGSSTSAELQGGLLPSREGSDEAPEQSVDSNIPIDPALLNEVEELASITEEQLAKEYGDVALDEEAVENNRELSSSNGKSLQVPEAWLHDENELENQISEMINDPNTKEHAAEYARAAKKVTTHMLMVSSKPVNMDVHIGEDEFADDPEVKNCLLAPEEVAKKEKIWVNENKVWLREQQKKLLDKKRAELDPPKATRRRKKKPRIGEGASVAESPAEAAKNMVKMRTWSKKINYDAINSMFKNKVGPGSAATSQVTSRAPSTASDSREGSAAPTVSEQAEDDEVETVVEPGKRHIPNEFGDDEIEEDEEYEEDPEQGDIDPFADQDPDDNFGVDDYEDYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8Q2</accession>
    <name>A0A3D8R8Q2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08753</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8Q2"/>
    <dbReference type="OrthoDB" id="10392912at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW70356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="218" mass="24411" checksum="71C4653F430C6642" modified="2019-01-16" version="1">MEGKGDHVEKMNAKFEATKLKIKQAQNLITRPNPKSDDVEKLLEAVKEREALYQQYNSLISGGESKILSLTADLHRKQVTLDTAIQHMKATGRMDAKRIAVLEASRIPVVECLVQCASDYQRLREYCEPAGTGSGRGGDEGEEPRTLKRSIGSRANSVDEIGRGEDNARAAKRYKENNEKREIEIEKREKVEKSRAEKAASLTKSPITREGQARSKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCR6</accession>
    <name>A0A3D8RCR6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_07881</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RCR6"/>
    <dbReference type="OrthoDB" id="4088837at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF87">
        <property type="entry name" value="SIDEROPHORE IRON TRANSPORTER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="142"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="556"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="76"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW71847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="595" mass="63826" checksum="3390D2CD3FAF7A6D" modified="2019-01-16" version="1">MTINDSLDGGRRSTSSLTPFEPSMTIAAASNSTVDVNTPLLSSPSHHPSPSSQPPPSSHSSRTKHARTWLASAPFAWVGILLLALAISLDAQTVQSLQTYALSTFAANGKLGILSSMQNFVTAAARPPIAIIADSYGRFESFLFSITILTIGFVGLALSPGLDTFMFSQFAYATGQVGIQFMETIIVADTSSLPNRALATAMPMTPWMITVFTAAPIVEALVPDHWRLGYGIWAIIVPVSGIPLLLSLYYREKRAARHQRPQTPKSHSPSIPKATFMHFDIIGFLIFTIGLAFILFSAAYATPGSYSTSSIVIGVLGFILLIVFCYYELHVASHPILALDLARDRTVACGCTLAFLLFGGFAIYQPYFYSYLVVSRDASPSIATNLGLVSLFVSVIAGLIASAAVKFTKRYKNIMILGVVIRIVAASLLLFFTTTTSSITNLTTAQFLVGIGTGMGGIIVQVGVQAAVSARDIATACALYATASSIGNFLGDLISSLIWSSMLLSRLEAELPVEAVGNATAIANSIMVAQSYAMGSVEREVINRCYVEVIRTLQGVGLSVFVVALLVCFLMKDIHLDREDPMSREDRIDAESFVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDK3</accession>
    <name>A0A3D8RDK3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)</fullName>
            <ecNumber evidence="2">1.2.4.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_08163</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + 3-methyl-2-oxobutanoate + H(+) = N(6)-[(R)-S(8)-2-methylpropanoyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:13457"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10497"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83142"/>
            <dbReference type="EC" id="1.2.4.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:13458"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.4" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDK3"/>
    <dbReference type="OrthoDB" id="878at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003863">
        <property type="term" value="F:branched-chain 2-oxo acid dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009083">
        <property type="term" value="P:branched-chain amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006091">
        <property type="term" value="P:generation of precursor metabolites and energy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007584">
        <property type="term" value="P:response to nutrient"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980:SF1">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42980">
        <property type="entry name" value="2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="5">
        <location>
            <begin position="78"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00051764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW72129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="402" mass="43895" checksum="79FD561FDC7DAEE4" modified="2019-01-16" version="1">MKATTRFGIRSLLAAALPRTKAPYSIIQQRRYSTPPPSAKLNLPTDFSTTPLLAHSSQSALQNPELPQEIRNGTTKRMNLFQSINDALALALAEDESVLLFGEDVAFGGVFRCSMNLAENYGAERVFNTPLSEQGIIGFAIGAAAEGMKAVAEIQFADYVYPAFDQLVNEAAKFRYRDGSEGRHVGGLTVRMPCGGVGHGALYHSQSPESLFTHIPGLRVIMPRSPIQAKGLLLAAIASNDPCVFMEPKALYRAAVEQVPTAAYTLPLSKAEVLKEGKDLTIISYGHPLYTCSAAIAKAEKDLGVSIELIDLRTVYPWDKETVLASVRKTGRCMVVHESMVNAGIGAEVAASIQEDKETFLRLEAPVLRVAGWSIHMPLMYERFNIPDVARVYDMIKNAVEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDM3</accession>
    <name>A0A3D8RDM3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative BRE4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_08025</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDM3"/>
    <dbReference type="OrthoDB" id="1924968at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023244">
        <property type="entry name" value="Brefeldin_A-sensitivity_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052430">
        <property type="entry name" value="IVT-Associated"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049453">
        <property type="entry name" value="Memb_transporter_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47804:SF3">
        <property type="entry name" value="PROTEIN BRE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13515">
        <property type="entry name" value="FUSC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02047">
        <property type="entry name" value="BREFELDNASP4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="839"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="892"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="domain" description="Integral membrane bound transporter" evidence="7">
        <location>
            <begin position="785"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="96"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW71991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1145" mass="127763" checksum="DB61D94F29F2A17D" modified="2019-01-16" version="1">MASSEGIESSRGSASISQSVDTPDPEPQLTPAAEPETQDSKTPNDTSQPRRRLLRRTNTGERHIRLAAPPIRPGGRQPGSTSSIYLGSFTPRRSKGSLSGSVKSPSGSAPGTPRHSIATSISQVHLEAILQDLNLDLETYGVEERRDGFFDGAFFKPAKTNFEDLMRAAEFTLPETFRKNHPLSPRSLLPKQWHDIKSVISQVATTRAGIKLTKTFLAFLISYILCLVPVVSSWLGRYSYIFVLSTIINHPGRTVGAQLEGALFTSLGSASGLGWGAFALWLSTSTSVVRRGYGGVLATFLLLFMVAIAALRSYYIRMYQFVLCSGIAIIYTCLADTSRNISWSKLFDFGIPWLFGQALCLIICCAVFPDAGARPLAVSLHAAFGVMQEGLVIPQSQQFIIHRRLAMTFVNLSQAYRDLVLDISFTRFPPKDVESLRNLMQAVIRSLLSLKMETLLFDNLQEDEIVPQREAGLRTSILDPGKIDMTSSDSTAPVDPGPVSGESVIDIDSIRRPAMSRTDSEDKAVKLVVNKLADPTSKLLACMRSALRRCDAVLMDMSGYRVYLGPPKSVSTDILDSLTRLRKTMIKYDEEEDSLLENPALPPSYSNQPEVVELFLFVHPVRQAASTVEALLVKVMEMQQSRRGWRPYLPSYPLSKALQRTNAAVRHDRGGLTAGYYFRSQSQLAKIMKGMANVYKPLPRQSSDPSSVNDPREDVTRMESMGKYEEEEDIAMNRSGHASKQKRLRYRIWMILHRLQGFESRFALKVGIVTSLLAVPAWLGPSRGWWNENESWWAVVVVWIMMHPRVGGNFQDLVTRAFCGILGAIWGGLTYGARSGNPYAMAVMASIFMLPMLYRFTQSSHPRSGIVGCISFVVVSLDAYKLNGQPSIERIAWTRGVAILVGVVSAVVMNWILWPFVARHELRKALSAMMIYSSIIYRGVVAKYVYYEEGEPPNKQDIERSEMLEGRLREGFVRIRQLLALTRHEIRLRGPFNPLPYSALIDGCERFFEYLVSVRQAAIFFHPHYMTDNDQAAESLLAYRRDAVATVLMNLYVLAGALRGDCKVPRYLPSAAAARKRLLDHMAELEVQQPTTNGNSRATAGADARKWSQIYSYSYSQSLTGCVQQLEQLQKYTKEIVGEQGFDPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RHW3</accession>
    <name>A0A3D8RHW3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative trehalose-6-phosphate phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_07079</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the trehalose phosphatase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RHW3"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005946">
        <property type="term" value="C:alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003825">
        <property type="term" value="F:alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03788">
        <property type="entry name" value="GT20_TPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01627">
        <property type="entry name" value="HAD_TPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1020:FF:000003">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000036">
        <property type="entry name" value="Alpha,alpha-trehalose-phosphate synthase subunit Tps2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000131">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1020">
        <property type="entry name" value="Trehalose-6-phosphate phosphatase related protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00685">
        <property type="entry name" value="T6PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF123">
        <property type="entry name" value="TREHALOSE-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="184"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW73637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="968" mass="107780" checksum="3A9E0BA33D53BA17" modified="2019-01-16" version="1">MSQPQNFSGQDAPLAESPQPIVPSRPGLESKASIHPGLHPNVVNVPVTPGIHVGEYSSGSSSKSGGAPSYFTHDVSRLRERMAQSPAEAASGANSDREILRRMSTQRDSLSEIDPRAANPSLGLSGSVISATFAVPHSLQYKKGSDWILNSRRGTSALFDSFAHLSSDKTPWNHTLVGWTGEITQNEDLTPPDTPPATTTASKMPPLNKNSAPIPVDGVARPATPTQAEGLWVSKEDQARLERQLSHDKHVKTVPVWLADDADMTENGICLKDQARWRRFAERELYTLFHYKQHEPTDGRSERQSWADYYRMNQKFATRILEIYKPGDIVIIHDYHLLLLPSMLRQRIPHMYISFFLHVPFPSSEFLRCLPRRKEILEGVLGANLIGFQSYSYSRHFVSCCTRILGFPSDVAGVDAYGAKVTVGVFPIGIDAAAIEKLAFDNKSIDEQTAALKKLYEGKKIIVGRDRLDSVRGVAQKLQAFERFLDMYPEWREKVVLIQVTSPTSVEEEKEDSGNKIANKVSELVAKINGLYGSLGFSPVQHYPQYLSQEEYLALLRAADCGLITSVRDGMNTTSLEYVVCQRDCHGPLILSEFSGTAGSLKDAIHINPWDLSGVAEQINYALCMTDDKRAAMQTNLYHHVTTKNVQAWSSNLLKRLLTVLSSRNTTIATPILDEVRMLRQYREAKKRLFMFDYDGTLTPIVKDPQSALPSDRLIRTLKALVSDKRNAVWVISGRDQEFLGKYLGHIPEIGFSAEHGSFMRHPGHSEWENLAETFDMEWQKEVMSCFEKYTEKTPGSFIERKRCALTWHYRPSDPELGAHMARECQKELERTVGKKWDVEVMAGKANLEVRPTFINKGEIAKRLVEAYSTEIGGGAPPEFTLCLGDDFTDEDMFRALNGREDLDPEHVFTVTVGASSKMTLAHWHLLEPADVISAVALLNGGDAAVVDVGALAAVEGRVPDDGPGDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RI51</accession>
    <name>A0A3D8RI51_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative tsa family thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_07050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the peroxiredoxin family. Prx6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RI51"/>
    <dbReference type="OrthoDB" id="2996783at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03016">
        <property type="entry name" value="PRX_1cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1020.10:FF:000001">
        <property type="entry name" value="1-Cys peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000011">
        <property type="entry name" value="Peroxiredoxin PRX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1020.10">
        <property type="entry name" value="Antioxidant, Horf6, Chain A, domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045020">
        <property type="entry name" value="PRX_1cys"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503">
        <property type="entry name" value="MCG48959-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43503:SF9">
        <property type="entry name" value="PEROXIREDOXIN PRX1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="4" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="57"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW73608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="272" mass="30059" checksum="693F5D86B510AFFA" modified="2019-01-16" version="1">MASVAGLRLMRALPITIARPLLQAAVPTRQQAAWRLIKPVASRAYSSTVLPKEQPRLRLGYTAPNFQANTTQGPIDFHDFIGSSWVVLFSHPADFTPVCTTELGAFAKLEPEFTKRNVKLIGLSANDLDSHGKWINDIDEVTGSSLKFPIIGDAKREVAWLYDMVDHQDLKNVDAGIAFTIRSVFVIDPNKKIRLTMSYPASTGRNSAEVLRVVDSLQTGDKHGVTTPIDWTVGEDVIVPPSVSTADAKKKFGEGNVRELKPYLRFTTLEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIE1</accession>
    <name>A0A3D8RIE1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Vacuolar protein sorting-associated protein 74</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_07257</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Mediates the cis and medial Golgi localization of mannosyltransferases through direct binding of their cytosolic domains. Involved in vacuolar protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">Golgi stack membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOLPH3/VPS74 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIE1"/>
    <dbReference type="OrthoDB" id="2189106at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070273">
        <property type="term" value="F:phosphatidylinositol-4-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048194">
        <property type="term" value="P:Golgi vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034067">
        <property type="term" value="P:protein localization to Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3630.10:FF:000002">
        <property type="entry name" value="Vacuolar sorting-associated 74 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3630.10">
        <property type="entry name" value="yeast vps74-n-term truncation variant domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008628">
        <property type="entry name" value="GPP34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038261">
        <property type="entry name" value="GPP34-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704:SF2">
        <property type="entry name" value="GOLGI PHOSPHOPROTEIN 3 HOMOLOG SAURON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12704">
        <property type="entry name" value="TRANS-GOLGI PROTEIN GMX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05719">
        <property type="entry name" value="GPP34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00058727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00073084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW73815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="356" mass="39063" checksum="BD6847033DFEBCE3" modified="2019-01-16" version="1">MSSGLTRRRGAGGGGGGVGGDNEDGDTSRVASPVPRGGGSRDTGPETSYESGENGHKIAFDPRDISESAERSKQPKLTLMEDVLLLGLKDKQGYLSFWNDNISYALRGCIVIELAFRGRISMQKDSSRRRFPLADRVIEVIDDTLTGEVLLDEALKMMKASEKMSVSSWIDLMSGETWNLMKIGYQLKQVRERLAKGLVDKGILRTEKRNFLLFDMATHPVADGGAKEEIRRRVRNVLTQRTVVLPGSQFLPDDLEFRYVRTIAMVCAAYAANVLENALSTLSHEARERAFAQVDELLAAYSQWPFGKITGGASGGVGANLGQVISEEVEKGKERELQLEVVAACLSVFTRLDSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJ20</accession>
    <name>A0A3D8RJ20_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit K</fullName>
            <shortName evidence="4">eIF3k</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">eIF-3 p25</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_07283</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit K family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJ20"/>
    <dbReference type="OrthoDB" id="337745at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000389">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.250:FF:000003">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.250">
        <property type="entry name" value="ARM repeat, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03010">
        <property type="entry name" value="eIF3k"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009374">
        <property type="entry name" value="eIF3k"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016020">
        <property type="entry name" value="Transl_init_fac_sub12_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="46"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW73841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="245" mass="27241" checksum="2739D788118EB9A4" modified="2019-01-16" version="1">MGVPFDYSPDRPDHINAILNGLDRYNPETTSIFQEYVAEQCEGKFTDTYANLALLKLYQFNPHLTKDETITNILVKSLTVFPSPDFSLALHLLPPHILTPVSVSSALPAAGDAPLSEAVQKLNVLNNLLGQASYSAFWSTLDSDDLYADLIADVAGFEELIRIRIALTISQSVREIEKQVLESWLGLQAEAFEKFVTGVCGWEIDGSVVKVPLNKENEAKGSIVRENVKIEQFSRVIRRAYEQPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJE9</accession>
    <name>A0A3D8RJE9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Bifunctional lycopene cyclase/phytoene synthase</fullName>
            <ecNumber evidence="8">2.5.1.32</ecNumber>
            <ecNumber evidence="7">5.5.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BP5796_07542</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>2 (2E,6E,10E)-geranylgeranyl diphosphate = 15-cis-phytoene + 2 diphosphate</text>
            <dbReference type="Rhea" id="RHEA:34475"/>
            <dbReference type="ChEBI" id="CHEBI:27787"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58756"/>
            <dbReference type="EC" id="2.5.1.32"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>all-trans-lycopene = gamma-carotene</text>
            <dbReference type="Rhea" id="RHEA:32219"/>
            <dbReference type="ChEBI" id="CHEBI:15948"/>
            <dbReference type="ChEBI" id="CHEBI:27740"/>
            <dbReference type="EC" id="5.5.1.19"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>gamma-carotene = all-trans-beta-carotene</text>
            <dbReference type="Rhea" id="RHEA:32239"/>
            <dbReference type="ChEBI" id="CHEBI:17579"/>
            <dbReference type="ChEBI" id="CHEBI:27740"/>
            <dbReference type="EC" id="5.5.1.19"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Carotenoid biosynthesis; beta-carotene biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Carotenoid biosynthesis; phytoene biosynthesis; all-trans-phytoene from geranylgeranyl diphosphate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">In the C-terminal section; belongs to the phytoene/squalene synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the N-terminal section; belongs to the lycopene beta-cyclase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.32" evidence="8"/>
    <dbReference type="EC" id="5.5.1.19" evidence="7"/>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJE9"/>
    <dbReference type="OrthoDB" id="6600518at2759"/>
    <dbReference type="UniPathway" id="UPA00799">
        <property type="reaction ID" value="UER00773"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00802"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004311">
        <property type="term" value="F:geranylgeranyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045436">
        <property type="term" value="F:lycopene beta cyclase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051996">
        <property type="term" value="F:squalene synthase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00683">
        <property type="entry name" value="Trans_IPPS_HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017825">
        <property type="entry name" value="Lycopene_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002060">
        <property type="entry name" value="Squ/phyt_synthse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019845">
        <property type="entry name" value="Squalene/phytoene_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044843">
        <property type="entry name" value="Trans_IPPS_bact-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033904">
        <property type="entry name" value="Trans_IPPS_HH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03462">
        <property type="entry name" value="CarR_dom_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31480">
        <property type="entry name" value="BIFUNCTIONAL LYCOPENE CYCLASE/PHYTOENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00494">
        <property type="entry name" value="SQS_PSY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01212">
        <property type="entry name" value="Phytoene_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01018">
        <property type="entry name" value="Squalene/Phytoene_Synthase_Lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01044">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01045">
        <property type="entry name" value="SQUALEN_PHYTOEN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="11 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00008247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00008406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00012242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00012396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00018909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RDW74100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="596" mass="67134" checksum="EC457051FC18D8A3" modified="2019-01-16" version="1">MGFEYAWVHLKYTIPPAIILSLLYRPFFTRIDAYKVLFLVSIAVIATTPWDSYLIRRKIWTYPPGVIIGPTFLAIPAEELFFFVIQTYNTALLYLVLSKPILHPNYLLGCFPGHQTPFKTIRNTGQFLLAACILVGGNLIRKGGEGTYLGLILVWAGPFALFLWSLSYQFLVALPYTSTALPVLVPTLYLWVVDTIALRRGTWAIESGTKLGIHVWEGLEIEEAVFFLATNILVVFGLVAFDNAMAVLLTFPRLFPQVPILPSPVLLMQALTTGCAKYDLARLDAIKQASRRLQSKSRSFYFASSVFTGRLRIDLIFLYSFCRVADDLVDEASSEGDAREWIIKLTKYLDLAYQSKETWLITEQPDVCSYITKNFPESTQSALRLLPTHILSFGPLYELLEGFKTDLDFHSDNSAKSSRNFPISNQQDLDRYCGRVAGTVGELCLELVFHHSKSPLTISQKENLVREGGRMGVALQLVNIARDIATDAKIGRVYIPKTWLKAQGLQPQDILENPNTSVTERFRESLLKRAFTAYLTSRDAISQLPSDARAPIRVAVESYMEIGRVLMKKGYQVKEGKATVPRLRRLKVAWKALSQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RK04</accession>
    <name>A0A3D8RK04_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_07613</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RK04"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="34"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW74171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="305" mass="33407" checksum="949059680EFC7FBD" modified="2019-01-16" version="1">MTENIVTTTSTVTMDDGACLHVKVLGDDPKATKPLLIALHGAPGLSTLVDPESSFAFLSGTFRVLVFDARGSGASDLTGPYTHERWINDIENLREWAGAEKFLLAGGSYGGFIALDYALLHGDRLLGIILRDTWANGAVGMMTALANIVTSDRLRVDVARQIRVWSGILYDDKDFEEGVMEILPIYDPPEGVSKKAPMSNDTGPKTFEGFVPTVSKYHSATQNAAFGVNMPRFDVRHRLKEIKAPTLVVVGRHDYIAPVHFSQEIADGIPNARLEIFEHSGHAPPADEPEKFQDTVWSFLKAEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RNG5</accession>
    <name>A0A3D8RNG5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Aspartate aminotransferase</fullName>
            <ecNumber evidence="8">2.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_06463</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:21824"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="EC" id="2.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3 8">Homodimer.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="8">In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="8"/>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RNG5"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006533">
        <property type="term" value="P:L-aspartate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000026">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000181">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004838">
        <property type="entry name" value="NHTrfase_class1_PyrdxlP-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF22">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00105">
        <property type="entry name" value="AA_TRANSFER_CLASS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="10">
        <location>
            <begin position="63"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="855"/>
            <end position="889"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW75642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="892" mass="100388" checksum="BCA9556A98B4599B" modified="2019-01-16" version="1">MLSSVRIAGRRVAVRGAAARSCNAIRAASTWDNVPQGPPQLTVARSKAILGITEAFKADSFKEKINLGVGAYRDDQGKPYVLPSVRTAEDQVIAAKLNKEYAGITGVPEFTKAAAVLAYGEGSDALDRLVITQSISGTGALRIGGAFFARFFPSKKIYIPTPSWANHAAVFKDCGMEVEKYRYYNKDTIGLDFEGMVADIKAAPKGSLFLLHACAHNPTGVDPTPEQWKEISDAVKAGEHFAFFDMAYQGFASGDTNKDAFPVRHFIEQGHNVALAQSFAKNMGLYGERVGAFSIVCENADEKKRVDSQVKILVRPLYSNPPVHGARIASQILNDPALNKQWLGEVKGMADRIIEMRALLKKNLEDLGSKHDWSHITSQIGMFAYTGLTPEQMDKLAKEHSVYATKDGRISVAGITTGNVKRLAEAIHASLNAARIRANKRHLVRNTLQAADLSETSRSVSQSASLPAELVELILLLSHRLSCPDIPLEQRQLLESTEQWALLQTYTPRIGELIASHLHNQALGLARILSPTSNPSFLHRQIPKIVPLVTEMQKRLLLQKLEIEQRRIGLVTKTTTLLGLYQMAITFTIHILEQNKHGAISRNAKTKSEYLVLSAKKEAAEAKILVGKAEKMVYTEDVKDALGNYERELRNGRERLKERRKMLERELWAYGIGREDDTKQRTMKEIARVYGEMVRELEEVRRDVKRLGGRSISTLIFSTDVSRRRQQQQRLRQDRPQHRFDIEAKHNHKVRRMSISQFNTSLSILKTARKQRPEMPSFLSKLPMFKKYGRVDLVTDDDFLTCLEMQSFNGAVAVQKTPNGKPTKPEEMGEILWDATEEEHFTKDDWFLTLIDMELTNLEAEFGEWKRKINEFDSKIQESQARYTKLEMELGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RNK7</accession>
    <name>A0A3D8RNK7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_06503</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RNK7"/>
    <dbReference type="OrthoDB" id="3501663at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01300">
        <property type="entry name" value="YtcJ_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013108">
        <property type="entry name" value="Amidohydro_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033932">
        <property type="entry name" value="YtcJ-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642">
        <property type="entry name" value="IMIDAZOLONEPROPIONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22642:SF2">
        <property type="entry name" value="PROTEIN LONG AFTER FAR-RED 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07969">
        <property type="entry name" value="Amidohydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase 3" evidence="1">
        <location>
            <begin position="84"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW75682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="622" mass="68488" checksum="E7480E493398523B" modified="2019-01-16" version="1">MPSRIVVVLAFLSTIAVPLFAGFPFLLKPSTLYCLSDQGSLSITTLNSTTPRAKCFRVQDGIFTGVFETKPKYSLLEKVVTIDGYVLPGIIESHGHILQYGEMLESVLLYGAESIEEVRQRIQQFLAEHEGEGYGSKEKWLRGIGWDQAYFGGVMPTAEQLNIPGLENLYIMLDRVDVHCVWVSNSVLSLLSDPLPEAPPGGVIVTDPGKGVFCDNAMDAIIYPVAPKPDVAQKTRWFRTAMKELNRVGIVGVGDAGMRAEDIQILESLAENRELSIRINVMLECEERNTYCPDEVKNLNILDGKALGGHTLMLGGVKLFADGALGSWGAALLEPYADKLDTKGTMLINETQLIKVVEEWFTAGFQVNVHAIGDRANRAAVDAFENVIGLHCDEQCNAGRRLRIEHAQIIDPADQKRIQAMGIIPSIQPTHATSDMAYALARLGDFRTSNSAYRMASLFPRADSKSAYPGPVLGSDFPVEPPNPFHGMYAAVTRLSPSTGTSPSGTSGWHPEQRLSLEQALLGFTRNGAYGWFKENQTGAIEVGKWADWVVVDRDFWADPSGSALREMEVKETWMGGRQVFGESSTPSWVVTTELWPMIERKLQDWSAFAVERLVGGQRAEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RP78</accession>
    <name>A0A3D8RP78_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">GTP-binding protein ypt5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_06713</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RP78"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016050">
        <property type="term" value="P:vesicle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000464">
        <property type="entry name" value="GTP-binding protein ypt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="186"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW75892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="218" mass="23595" checksum="D6305675FF82CABA" modified="2019-01-16" version="1">MAARGPGSRAGNSRFAQFKLVLLGESAVGKSSLVLRFVKDQFDDYRESTIGAAFLTQTISLDDSTTVKFEIWDTAGQERYKSLAPMYYRNANCAVVVYDITQASSLDKAKAWVKELQRQANENIIIALAGNKLDLVTEQPDKRAIPAADAEAYAREAGLLFFETSAKTSENVKELFTAIAKKLPLDQAGPRNPRSGPRAGVDLRPEAPGTQGAGACSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RP92</accession>
    <name>A0A3D8RP92_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MFS general substrate transporter-20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_06646</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RP92"/>
    <dbReference type="OrthoDB" id="433512at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="399"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="441"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="468"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="504"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="547"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="48"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="307"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="325"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW75825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="646" mass="72525" checksum="92D042BCD3B5B388" modified="2019-01-16" version="1">MVLWGFRWFKLFLNPYESDEFEHIKEADRRAYIIGRLESAEFSEWSWVIVVAGVGFFTDAYSIFAINMVVPLLGIVYYGGTLPHNYETALSVVTLGGSMLGEIGFGLAADLWGRRKMYGLELIITIGATLGVVMSSNGTQGSMSVIVWLLIWRFVLGIGIGADYPLSAVICAEFAPSRLRGRMLTLVFACQPVGQLAATLVTLIAVVRQRNSIPSDATPTSCDSECIRTLDSIWRWVIGVGVIPAVIALWFRLTIIESPRYTADVGRDTRKAASELDRYLLSQEESIVASAVSIQQAREMDHLTRQESVEVESIGESGYEEPLDNDGHDIERIPPSEDKPPPEPSWQDFKQYFWYDGNLRTLIATSLCWFCVDLPFYGLGMNSSNIITRIWWGRDPSPATIYAGLISNVWQSLVIVSLGALIGVAITFVAIDKLGRRTIQIIGFFWLFILFVVIGGSFNHLYEVKGQAAVVVLYILCQIFFNFGPNTITYIISAELFPTRYRGLCHGISAAFGKLGSVLAQLFLAYVKYGPNGYNYKNVQRWLPYSLLIFSSFMLCGLLMTIFWIPRAEHGPDGAVKTLEEWELGREKNGFAETRAARTFFWLYKGITGKLDTFYLWLDKMIGGDEAEKRQLLKEQTRMRELAQAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPL0</accession>
    <name>A0A3D8RPL0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Geranylgeranyl transferase type-2 subunit alpha</fullName>
            <ecNumber evidence="6">2.5.1.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Geranylgeranyl transferase type II subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_06562</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="6"/>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPL0"/>
    <dbReference type="OrthoDB" id="1658at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF2">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="80"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="91"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW75741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="392" mass="45437" checksum="F2948160E5348C51" modified="2019-01-16" version="1">MASHGVPRPSTITTKDEQARLKEEKDIKDYKTLVDLTSEREYSLEVLELTSKLLTKNPEYYTIWNVRRRLLTYGLFSKPSDSSLPSMELPSTSQTDTTITSSADSSSSSSQATPPSQNSRMTGKTGTTLEAIKNDLAFLVPLLMGWPKCYWIWNYRLWLLQQAKERLDMEIARAMWTQELGLVGKMLTRDNRNFHGWGYRRKIVAELESPELGGSSMVETEFEYTTKMFSASLSNFSALHTRSKLIPKLLNERRSDDGARLRFLTNEFDLIAKALWTDAYNQSAWFYHEYLMTNLLEPVRQSTITPNMSSTERSAYVVLQIENVKEMLEGEEECKWIYNALLGNTMALWQLEERSPMSDELQDCKTWLAELRKLDPLRRGRWDDLEKEFRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPP5</accession>
    <name>A0A3D8RPP5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_06747</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPP5"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11058">
        <property type="entry name" value="CYP60B-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF210">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE ASQL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="380"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW75926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="384" mass="43251" checksum="32EC5F969F4B42F1" modified="2019-01-16" version="1">MTGAFYLEIDRLHRKYGPVVRIAPNSLSYTNSDAWNDIYNLGVDKQELSKSRIFLGETKDAGIIGSTWHNHQRIRGSFKNAFSTQAMKEQEPRILSLVNLYIQRLHEHAMQGPVDIQAFYIYATFDIMGDLAFGESFGCLEGMIYHRWIKVINDMPQALTAISMLNLFPPLNKLVSYLVPKSARETQRWHKEYAVDKIQRRIAQKEARPDFMTYAIANRDTPKGPTMKELEVTAGTLVLAGSETSASLLGGITFHLLKNPDKLAKLTAEIRSSFASESDINMTSVNSLKYALAVVDEGMRIFPPVPGTLYRTTKAGGNMIAGRYVPPNINVGVAHWATYHSPDNFKDPHRFVPERWLGDPAYANDNRLALQPFQVGPRNCIGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RQ31</accession>
    <name>A0A3D8RQ31_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EthD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_07013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tpcK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RQ31"/>
    <dbReference type="OrthoDB" id="3454835at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009799">
        <property type="entry name" value="EthD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07110">
        <property type="entry name" value="EthD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EthD" evidence="2">
        <location>
            <begin position="23"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW76192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="141" mass="15895" checksum="E2ABF27EFF45E782" modified="2019-01-16" version="1">MATHTGTEKLLKICVNHYKAAECSHEDFEKFMTTSHVRAAAGIIARHDVVKYAQYLTPPTARAIFAPDVSTLPPGWSLSPYDAQTQYYVRSADDLRGLLMDPEWHEKVSKVETAYTNVSEVMIMVGWETVYIEDAKVINVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RQJ0</accession>
    <name>A0A3D8RQJ0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Methyltransferase type 12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_07027</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RQJ0"/>
    <dbReference type="OrthoDB" id="429813at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041068">
        <property type="entry name" value="HTH_51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050444">
        <property type="entry name" value="Polyketide_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45681:SF6">
        <property type="entry name" value="POLYKETIDE SYNTHASE 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45681">
        <property type="entry name" value="POLYKETIDE SYNTHASE 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18558">
        <property type="entry name" value="HTH_51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase fungal type helix-turn-helix" evidence="3">
        <location>
            <begin position="20"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase type 12" evidence="2">
        <location>
            <begin position="211"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF18558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW76206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="42577" checksum="32D9F11C465C8384" modified="2019-01-16" version="1">MPHTDEDSLNRASVLNAFQNIKDATDDIILKNNMDTYCEEYLPRSNELAIAIVSQAFEILGCKAQSSAPGTQLALVESSPNHAKLINWMYKVLEEAGLIEIKGKDKNVIVRTSMPCPSDDLETLLEDLLDDRPGQSFELQIIEIVGPAYADSISGKTDAVNLLFSNDHGRALLSNFYAKSDLTSTVLDQLALFLEKFGGTWKKENGPLRILEVGAGTGGTTWRMLAVLKRLGIPYVYTMTDIGSAFGAAAQAKLAQYPTAEFKVLDIEKEPEAELQHTQHIVFGSNVFHATRDLNVSMAHVHRLLRPDGFLVLHELTTQMLWSDLMSGLFPGWWAFEDGRRNTIQSAQDWAKVLKSVGFDHVDWTDGQRPEAKVQALVIAMNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVN3</accession>
    <name>A0A3D8RVN3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_05900</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVN3"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="6">
        <location>
            <begin position="85"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="140"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW78048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="562" mass="60932" checksum="30829FE411D3E173" modified="2019-01-16" version="1">MTVSATKTPADFEAAIQAKHAQQLELIPKEWHIPAHKLPPAEQARVIEFTSECGILSAEELAIVTKDAGDLLADLASGKLSCLAVTTAFCKAAAVAHQLTNCLTEIFFTQALARAKELDASFAEKGKPSGALFGMPISLKDQFQIKGTECNMGVASWIGQISKENSVLVDILQDAGAILHCRTNISQALMFAESDNYVYGQSTNPFNRKLTPGGSSGGEGATVAMYGSVVGVGTDLGGSVRIPASYNGLYGLRPTLHRLPYAGARNTLLGLEAIASALGPISHSLSGVSAFVKAVVDAKPWFLDPKTPEIPWRQDMANLEHLVDSEGKPRKPVFGVMRWDDYVMPWPPMKRAIDMAVEALKKSGYEVVVFKSPFDAKEAERIVQTVYSSDGGEDLSRTFAPSGEPWHPMMVTANGSPHLTVYESWQLNQEKDEVKTAWLKAWNATSSLTSTGQPIDGLILPPSANVAHMHGKWPRNIIYTSLFNMIDYPGMVIPVHSAVDPNLDPIDKEYKPANDRDAEFQALYAPEDYAGAPITVQLVCRRFREEECIGLTSVIADALKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVU8</accession>
    <name>A0A3D8RVU8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 7">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_05783</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW77931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVU8"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.310.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041640">
        <property type="entry name" value="Tyrosinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF32">
        <property type="entry name" value="TYROSINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18132">
        <property type="entry name" value="Tyrosinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017562312" description="Tyrosinase copper-binding domain-containing protein" evidence="5">
        <location>
            <begin position="19"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="6">
        <location>
            <begin position="123"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="7">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW77931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="618" mass="68773" checksum="9E9FD936979C1CB8" modified="2019-01-16" version="1">MLLLAFFAFLVCFSWSAAADGGPYNYGMEARSIYARNAATDYITTGIPISTNGTPPLRLEIRDLEKDNATWTLFILALDMMQYTNQSELFSWYQIAGIHGRPFYSWDNVNGPAEDQGNGYCTHVSILFPTWHRPYLALYEQIIYGITQYIATLYPVGSVRDDYVAAANRFRIPYWDWAAVPSSAHTTADSLMTPTISVDGPNGVQTIHNPLFDYDFKPLISDDLPDAPFDVFPRTQRWPSNMTAASVSRNDQMAAALDNSASSLRNRLYNLFTNYQNYTEFSNEAFSNSVYYDSIESVHDFIHGYTGNGGHMTYIEYSAFDPIFFLHHAMIDRCFALWQVLNPDGWIQPEPATYSTFTTTAGDIEDSRTPLTPFRNDSNGGFWISDTSRETAPFGYAYPETVGGPGVDIKSVVTNAINNLYGTTAPANVVSRDQFRTRRSTSEVHNRALSYANAAGLPHDLVQNNQYSEWIVNIRVRKRALSAPFFIHIFLGVFDPDPVTWPFEPNLVGSHSVFTMAPKGMNSCVQCNPEQVISGTVPLTSALLAEISKGSLHTLDSSQVVPHLNQNLRYKVAMADGTEVGNVDSLSINVVSAPVQKPDGELPIWGAMEVQIESVICG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWA5</accession>
    <name>A0A3D8RWA5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">L-ornithine N(5)-monooxygenase [NAD(P)H]</fullName>
            <ecNumber evidence="4">1.14.13.196</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_06147</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-ornithine + NADH + O2 = N(5)-hydroxy-L-ornithine + NAD(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41512"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-ornithine + NADPH + O2 = N(5)-hydroxy-L-ornithine + NADP(+) + H2O</text>
            <dbReference type="Rhea" id="RHEA:41508"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:46911"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78275"/>
            <dbReference type="EC" id="1.14.13.196"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Siderophore biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.13.196" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWA5"/>
    <dbReference type="OrthoDB" id="3519933at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025700">
        <property type="entry name" value="Lys/Orn_oxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802:SF1">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42802">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13434">
        <property type="entry name" value="Lys_Orn_oxgnase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW78295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="480" mass="53116" checksum="2A7CB30770BD32D9" modified="2019-01-16" version="1">MSSGEMNANISADTGVSASTQKLPIMPSSDIQDLICIGFGPASIAIGVALTDAQLLSPNVTFLERQPKFSWHSGMQLPGAKMQISFLKDMATPRNPHSHFTFINYLFAKGRLNNFINLSTFLPSRAEYEDYLRWVARYFEHRGVVRYGQEVVAVEPQKSSSGKVSHFNVTSRHVATGEVTTRSSKRVVVAVGGKARLPPQFPENHPQIVHSSQYSSRVHRTLPDSQRPYHIAVVGNGQSGAEIFNDLPSRFPNAKVTMIIKGAHLRPSDDSPFVNEVFDPDRVDGTFAQDPEVRAQAITLDKATNYGVVRLELLEHLYDTLYSQKVKNPDPSSWCLNIIPKRQVVSTATVDDKLLLKMKWVEGGNVVNGDDSELAVDAVFVATGYLRNAHEDILKQTRDLLPEAQREGTKFTVSRDYKVLYDESKIEEGAGVWLQGCNEKTHGLSDSLLSILAVRGGELVESMFGKELASSGVERVRAMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWC0</accession>
    <name>A0A3D8RWC0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vps41 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_06205</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWC0"/>
    <dbReference type="OrthoDB" id="244107at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057780">
        <property type="entry name" value="Beta-prop_Vps41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045111">
        <property type="entry name" value="Vps41/Vps8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12616:SF1">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23411">
        <property type="entry name" value="Beta-prop_Vps41"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23556">
        <property type="entry name" value="TPR_Vps41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Vps41 beta-propeller" evidence="5">
        <location>
            <begin position="55"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Vps41 beta-propeller" evidence="5">
        <location>
            <begin position="172"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Vps41 beta-propeller" evidence="5">
        <location>
            <begin position="385"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="3">
        <location>
            <begin position="915"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="138"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="453"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="660"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="26"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF23411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW78353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1276" mass="140353" checksum="19A9630E05B72416" modified="2019-01-16" version="1">MAEGSEDPGDTDKKPDDADPTQSGDDTVDADDEDADDSEPDEEDDDDEEEEEPKLKYARLTSHLAPVYRNGDATSAFLVAGDKMFIGTHNGNIHIISLPSFQQIRSYKAHQASVTSISISPFPPPLPNALPEAVTRIASQSHHTPKRTPSIASEAPTNSPRTPNMKLVSNTQSNAIYIATSSIEGKVCISSLVDVKDVQLRDFQRPVQAVSLSPDYKNDRSYLSGGLAGSLVLTVGGRAGTTTTSTTVNTTAAAAAGWLGSMGLSGNNGKDSVLHSGEGTISTIKWSLSGKYVAWANEHGVKIMRSHLHLESADAESAWKRVGHVDRPQEDEWEEMASVWKARIEWIDEKSLETDEDDKAQVIASSSPVAAKLRQQVLKSNGRIEKLLVGWGGTIWIIHVHPGGTGIGKHVGERSVGRAEIIKILRMDCIISGLSLYTPTLLLVLSYITPDNDEVNESSKPKGHKSKDSTASSSSEPSGGVRRRQNALSPELRLIDLGTSEEVDTDSLTVSRFERLSAGDYHLGVLPAPRALPIVPTSRGTLETLTGMGSGMWNATINATALLSSSQSVRSSGSKSDADSATKVSSMAGSLRNRFAAPSHVAHPNITTPSMKIFIHSPYDCILATKRDLADHLSWLLENSRLKEAWELLDNNPEIISSSPERLAEIGPGVPEPRRAESDDFDDDGTSVAESASKLINSSVEKEKRRIGELWIQQCIGKNDWTEAGKVCGQVLGTSTRWEYWVCTFADANKFDEITNFIPTTQMRPPLPSIIYEVVLGYYIAHDRPRVKSLLEQWSPDLFEIKSITTALENQLKYRDVRPDSVEDGVKGRDWRIVMESLGKLHIADGRPREALKCYMQLQDADTAMALIKDSHLVDAVADDIPGLILLRVSKEQARSASVEELQEATSEAIALLVNEAHHGLVRPEVVVEQLEEKNMPLYLFFYIRSLWIGDGVEEQPGESRDRVITESKSFVDNLADLAVHLFATYDRELLMDFLKSSTSYAFEKATQECEERDYVPEMVYLYSKTGQTKRALYLIIDKLSDVSQAISFAKQQDDADLWEDLLNYSMDKPRFIRGLLEEVGTAINPITLVRRIPEGLEIEGLREGLSRMIKEHEIQHSISSGVARVLRGEVAMAQTTLRSGQRKGVKFDVVRKEPDHVDVSPSDVPTNTNDVPAAQTAKEFSKDKVAQPGHCVGCHEPFSEHEIETLIGFACGHVFHLSHLLSYSKDSRPVTPPDVELDENGEFTQTHSIGAKVTHARLLRDQIADGCPVCKDIPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWD2</accession>
    <name>A0A3D8RWD2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glycosyl transferase CAP10 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_06177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWD2"/>
    <dbReference type="OrthoDB" id="541052at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006598">
        <property type="entry name" value="CAP10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051091">
        <property type="entry name" value="O-Glucosyltr/Glycosyltrsf_90"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203:SF22">
        <property type="entry name" value="CAPSULE ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12203">
        <property type="entry name" value="KDEL LYS-ASP-GLU-LEU CONTAINING - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05686">
        <property type="entry name" value="Glyco_transf_90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00672">
        <property type="entry name" value="CAP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase CAP10" evidence="2">
        <location>
            <begin position="320"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW78325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="633" mass="72470" checksum="4740C44D6267D689" modified="2019-01-16" version="1">MAYPGPPRKVNSLIRYIAVAVVLLAGLFYFKHSAYSLSAPQYLGTAPTTEQAPLVPPAEAEHPFVEAPPPRPEPTPAKVHAIDTLIADADKRFDEMMKKECHDLKCAAAEYRKRRGRHPPPGFDTWFKFAQENGAVIVEDFFDQIHHDLAPFWGFHPAQMRKEASEFEMNINIRNQKASAESEWFWTQIWLNLTQTIEHLLPDMDIALNAMDEPRIVVPWEEINEYMDIERQTRNMPAVADVIQTYNSLPPPTEGDMDMEVASKNWEDDLPYWKIASRGCHPESLARKAEIMEDFSHSPSLSLAHANPHTYRGYVSNYSQSTDFCHQPDLQGLHGALIHPLSVSATSQMFPLFGGSKLSTNNEILLPAPMYWMGGERFSGGNDHGGAWAEKMNHVIWRGVATGGRNTEDNWKGFQRHRFVAMTNATQVSRAESWESIPQNFALPSSQYDLAAQHENRLGEWISEWADTGFVDLMCEPQQDNGTCEYTGHYFAVTPGMKMGDQFDRKYLPDIDGNSFSGRYRGFLMSTSLPIKATLFKEWHDSRLVAWKHFVPMDNRFLDFWGIMQYFLGYEGEKTRIESHDAEAQKIANAGQIWANRVLRKEDMQIYVLRLLLEYARLSDERRELMGYVQDLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RX82</accession>
    <name>A0A3D8RX82_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_06296</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RX82"/>
    <dbReference type="OrthoDB" id="5572108at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10206">
        <property type="entry name" value="ASKHA_NBD_Arp8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000232">
        <property type="entry name" value="Actin-related protein 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.580">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="60"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="194"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="676"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="74"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="677"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="708"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW78444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="876" mass="97683" checksum="2655D2C7B2C8CCE3" modified="2019-01-16" version="1">MGTNEQAIEDRYQRGLAKLRALRNSNRGYVKGENQRLKKCRTSSLYDFCRRQCVRRARLGSAAESSSSSLQDGQQDDQDDDDDDSEVSLLLPNLSPDYGLQNKSAQRYLNSSAEAGDNTMAGKKSGKALLREEGLERTDNGMKQTSWPETPMINQKNYYTEYMKRDDQILALRLQNDANRDRMIRDAKDRDRALARTGNTDVPMPLNGDGVPEEEDAAATDDLDASKTVVIHLGSQNTRIGFANDALPKTVPTTIAYHFPCTEAEEYAALPKRQKIETKPEEMFGEEFAKKFVKMSNDLKIDMRANKRKVLPNSKELVVNFNKRTPPEKIPEHNDPMRIEWTEVLPLDKDGKMQTAEFFTGVDAQRIPDDSDPKYKLFWPIQNGWPNEKEYANANGYKDDLESILEAALKKELGLKHSRSWADYSCVFVIPDLYEKKSLEHALEMFLKEFEFKQIAFIQESLAATYGAAYTCTCVVDVGAQKTSICCVEDGMCVEDSRINLKYGGYDVTETFIKMMLFDHFPYADINLKRRYDFLLAEELKVGFCTMNQADIAVRLYNFHLRAPNQPTRKYEFKTYDEVILAPMGFYDPTIFDNSEKLVGRRKLIERSYNAYDTDIPDDPTSAAQLEILSSIKPSLATSTNGLSLLNGNGTTGLPEISTPSKEKLQPFNFLSRMDSEANAASRATSAAASPAPEGSNTPVPAAPFVFGANGTNGTNGASPGPGMLANGSHNGGTPIPPGGMFVDPHARTAKDMAVERDGVLPIAPLDSAIITSIKHAAKGDEKKVRDFIGGIMVIGGGAKTPGFVPFLEEKLKARRPDLAEKILVGSSPREMDGQVVVWKGATVFARMTTHESWISPLEYERLGARVLHHKVMWHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RXD1</accession>
    <name>A0A3D8RXD1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Molybdate-anion transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Molybdate transporter 2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_06346</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RXD1"/>
    <dbReference type="OrthoDB" id="263957at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17487">
        <property type="entry name" value="MFS_MFSD5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008509">
        <property type="entry name" value="MOT2/MFSD5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23516:SF1">
        <property type="entry name" value="MOLYBDATE-ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23516">
        <property type="entry name" value="SAM (S-ADENOSYL METHIONINE) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05631">
        <property type="entry name" value="MFS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="84"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW78494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="417" mass="46162" checksum="43D9BAF38886412C" modified="2019-01-16" version="1">MVGGHSAESVAAAEAVNWHFKMKFLPVYLLVFGADWLQVDRIFTLYQKGLAEETVAHLFTTGFLAAAISASFIGSLADRYGRRAACLTFCVTYSVSCFTVLFDDIIILFLGRMLGGLSTTLMYSVFESWMVTEYHRQHLDDAGGSLSELFGIMTALNSVIAILAGLFAQFMSDFTGTQAAPFMTAVVCLVSAFLLISRRWSENYGDSAKFNALLPNVIPEKSGYQIILDDKRLWALCITSCFFEGSMYLWIFFKFPALRLTHELNGLGSDLPFGMIFAALMCAMMLGSLFFTWYSSLPRGPYVVGPSSLLMFALLLASSCFLIPVLYRDEASTFWCFCLFEFCCGIYFPTIGTLKEKIVDDGVRAKIYGITRIPLNLFVFFGLAFTQDGERHRDNMFMVLSGALLAAAAAVGTLLLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S220</accession>
    <name>A0A3D8S220_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Beta-lactamase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_05051</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S220"/>
    <dbReference type="OrthoDB" id="3478025at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF7">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017763980" description="Beta-lactamase-related domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="227"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW80353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="565" mass="59988" checksum="04363F8C332F9A8E" modified="2019-01-16" version="1">MGAVTMPNWIPRLTVALALANLPGSHAMPPHFQILPIPILTNFSVPLNITLPHPPPPLPVLLDPTSATAPFPSTPPAPNTAPAQSVTTALSLPLPTSLSLPTSLSLPTTPSLSSSLSLPSDVSLSISNGTLSSSASSSSASSSSVSSSSASSSRPQPTANPRYCTLPLAGAGFQTAIGVEVNMIQDIIDLAIANFSQNGAVSIKVFRHNCLVGESTNSAVTDPIKKNIFSATKGVISILTGIAIDQGKLHIDDQIGQFLPNYPGWGDPIHRSITIRDLLTETAGFQAALYSEGLTVGYDLSLPQEALGQAMIYPPGTHFTYSQRVPDLLAYVVSQAVGQELQSFAQQYLLTPIGIPDTDYTWLKDLSGNTYGYAYLYLTAPDFARLGLLMQNGGTWNGQRVVSQAWVDAVHVPDATNGCYGLLFWTNAGHTCFAPSGYPFNRSWVPSAPTDLFAMSGSPQQKNFMIPSLDLTVSWAGVLTDVTPYSGIFYEFFTMLMTAFTDEPPLPPGIYNPEPYTIWPLIDSYDAAVLTADSLSSPVCNALWCNGGVPMVAPLDLGKLLPILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S226</accession>
    <name>A0A3D8S226_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_05027</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S226"/>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF4">
        <property type="entry name" value="HYPOTHETICAL CONSERVED PROTEIN (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="2"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW80329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="512" mass="57629" checksum="7558FCDF1FD73FB0" modified="2019-01-16" version="1">MRHVKCGEEKPICIRCISLGASCNYAGLSKKVALPLKLQVLAPRPRIQEISSTFQIEIDEGYQYFELFRDKTSFQILSHTSDIQSLRLILLQAGVLESSIRHVIAALGALEKVSETTSNPVKVGRNDYLGEPERHYQNAIKLYSHAISQMQSAVSNGTQDYRTTLLTCLVNQCFEAWTGNQDLALQQMQIGIKLIQQWKVDTRNPPRDSSVIVTAVEADLVRAFDRLAIQVVCFTAPAARSPVCNVSLSRDGREILSHIPLNFTSLQEAGIYQSSVMRYGMHLITTLLSKPEPVPSGRIYPFNCNAEITEAVLAELNTLIVHIKQWYAAFHALSQSELANGGENMTIAATLKIHVYTVHLCLVGLLAADETVYDSYHEKLSEMVDLAEMIIKARSNESSRGHFAFDLGVIYSLQLPAQKCRDSRIRKRAVALLSENPRREGVWDSVFVGKMMEWAVDVEEEFMKDGYIPAWARIRGVAQSADMQRRRATLLCQQRISEDSDELIIRQKHICW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2Y3</accession>
    <name>A0A3D8S2Y3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_05365</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the xlnR/xlr1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2Y3"/>
    <dbReference type="OrthoDB" id="5365785at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.240.10:FF:000004">
        <property type="entry name" value="Xylanolytic transcriptional activator XlnR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051439">
        <property type="entry name" value="XlnR/Xlr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663:SF1">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="51"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="130"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="258"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="551"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="727"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="262"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="558"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="744"/>
            <end position="757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW80667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="934" mass="102400" checksum="6539C7DAD7C8018B" modified="2019-01-16" version="1">MLSNPLHRFSTYSSVPSNSMLSNGQVPSGHMHNTGLGGLAQSSQYALHHLPQQTQSPQAGRSNKRHHPYNGQPGARSSNANSGPVRRRISRACDQCNQLRTKCDGQTPCAHCVEFGLGCEYMRERKKRGKASRKDLAQQAAAAAASGQKSPNSQSSGRSPSESRLDHSLSAATENSDFRRPNSRSLSLNTGGIDAGLRKFRENRHRTGSLDSLEMQTQSHMTHPVDDALHQDPIGSPSSLSMNGYSNLHGYRPVLDPHLVNTGGNHPNYNSGASNLSGYPDLQYMPQSPPAYPGNHSTSYRLGDSPLPGFSIGHDAASPSWMSLPSPSNQYQQVPHHSFNPPLRYPVLQPLIPHLGNILPTSLACDLLDLYFASSSSALMHPTSPYVLGYVFRKQSILHPTKPRQCTPALLASMLWVVAQTSDATFLTAPPSSRGRICQRLLELTVGLLKPLIHGPPPGDVPPNFSNTVINGVALGGLGVAVPGSINTDSLGGETGAFGASGALDDVVTYIHLATVVSASEYKGASLRWWNAAWTLARELKLGRELPYISPAQANDSNDTDADADAEDMPTPGMITEEEREERRRIWWLVYTVDRHLALCYNRPLFLLDIECDGLLQPMDDTLWQAGEYYTGDSNIHITSPSGTPRIRTRGPNFQCTGHSIFGYFLPLMTILGEIVDLYHAKNHPRFGIGFRSAQEWDDHVSEITRQLEAYGSSLAEFEARYISQPTEPEQSMEGQTPLDVGTPVQSVHSAHTSSTTRVRTESDFQTKIVVAYGTHVMHVLHILLSGKWDPISLLDDNDLWISSQSFIDATGHAVSAAEAVDNILEYDPGLEFMPFFFGVYLLQGSFLLLLIADKLQIEASPSVVKACESIVRAHEACVVTLNTEYQRNFRKVMRSALAQVKGRIPEDFAEQQTKRREVLALYRWTGDGTGLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S360</accession>
    <name>A0A3D8S360_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_05298</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S360"/>
    <dbReference type="OrthoDB" id="5346159at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990862">
        <property type="term" value="C:nuclear membrane complex Bqt3-Bqt4"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048315">
        <property type="term" value="P:conidium formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070197">
        <property type="term" value="P:meiotic attachment of telomere to nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044820">
        <property type="term" value="P:mitotic telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030435">
        <property type="term" value="P:sporulation resulting in formation of a cellular spore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037548">
        <property type="entry name" value="Bqt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018004">
        <property type="entry name" value="KilA/APSES_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38044">
        <property type="entry name" value="BOUQUET FORMATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38044:SF1">
        <property type="entry name" value="BOUQUET FORMATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04383">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01252">
        <property type="entry name" value="KilA-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0183">Conidiation</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0749">Sporulation</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="388"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="HTH APSES-type" evidence="5">
        <location>
            <begin position="64"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="192"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="336"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW80600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="409" mass="44959" checksum="5D939EAC09AB0BFB" modified="2019-01-16" version="1">MSAYVRPHKLPARYNELLNENIPPYEELVSRRRLGQTDLTVKAGQVGTSNSTKPKNLGTFDYAHLRAPLPKGIMSGIFRPSPNSYFLMRRSQDGYVSATGMFKASFPYSDVEQEEAERRWLKTLSSTSTMETAGNIWVPPQQALELAEDYKIVQWIKALLDNTPIEQNPTKETQPKSISPPPKFEFLQPQEALTAPVQSSRSRSLRSASPSKIVSPRKTGTTRSRKARAPSETPSVPATSKAANKKLQQALKAASIDAEATPSEITEDSEAKEPEANEDPVVRVNVDTDVQVQGDVETTRTHVDVEIPAGFAEMPLPEDTEKMIAKAKEMVEAAVKGTENASSSDSKKVKRKLEEVEAEEEETALIPAPAKKAKVETELKKERVKTRALIGLSATLAIGAIIPYVMGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3H9</accession>
    <name>A0A3D8S3H9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative mannosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_05514</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3H9"/>
    <dbReference type="OrthoDB" id="439943at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000032">
        <property type="term" value="P:cell wall mannoprotein biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000051">
        <property type="entry name" value="Alpha-1,2-mannosyltransferase (Ktr4)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002685">
        <property type="entry name" value="Glyco_trans_15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31121:SF6">
        <property type="entry name" value="ALPHA-1,2 MANNOSYLTRANSFERASE KTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01793">
        <property type="entry name" value="Glyco_transf_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="44"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW80816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="418" mass="48198" checksum="941D978C4A07C59B" modified="2019-01-16" version="1">MASGTSRYLRYILFAFFGLTVIYFISSSSTQRLPSANDILNGGKTSWSQGAQSPVSGGKAPADSQVAPVVPAATSPATTPNTAASLPPATAPGERMNATFVTLARNSDIWEIARSIRQVEDRFNRKFHYDWVFLNDKPFDATFKKVTTALVSGKTHYGEIAKEHWSFPDHIDQEKARKVREDMAQRKIIYGDSISYRHMCRFESGFFFRQPLMMNYEWYWRVEPSIELFCDIDYDAFKFMADNKKKYSFVLSLYEYVETIPTLWDSTKKFIKEHPEHIAEGNSMGFLSDDGGETYNHCHMWSNFEIGNLNWLRSKAYIDYFESLDADGGFFYERWGDAPVHSIAASLLLKKEEIHFFNDIAYYHVPFTHCPTGEKTRLDLKCHCNPKDNFDWKGYSCTSRFFELNGMEKPEGYENQQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3T3</accession>
    <name>A0A3D8S3T3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glycogen debranching enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_05647</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3T3"/>
    <dbReference type="OrthoDB" id="2591256at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018909">
        <property type="entry name" value="Eng1_septum"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10645">
        <property type="entry name" value="Carb_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017645672" evidence="1">
        <location>
            <begin position="20"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="domain" description="Endo-1,3(4)-beta-glucanase 1 carbohydrate binding" evidence="2">
        <location>
            <begin position="26"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW80949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="792" mass="85817" checksum="28E646F4F7312FAA" modified="2019-01-16" version="1">MLLFGKLVATFWLVALVVGQEDLRPCGDAFYSPAKYTCYDSDFLCPVLAGTPTLRCGGDCYLPSMYSCAGNHLVYPPKAVTASSETSCASAATTLHLSSPPYENYFSSDCHSSAQVVVTSPLPGSNLTVISPRIIVAWPAGNSGVVTYFAPENGINGSLGINLLNVTSDFPLQPIYRPGENATNGISMQLQLNSSAVLPVAILGSIRTVRDFTEGPSLLRSQIQSALQFSQIDNGVEISRLWLDNITTTTISFTSIDSVVQIDNTTLIFEAGTYTYNASFNYPQLEQISSTSVLNPDSQALITQSPEQTESLSFLSYTTKLTAGAWRFLTYFGRDSMIAALLLQPVLSQGDGGAIEAVIAAVLERINSTDGSVCHEETIGDYATWLNLQENITSTAPSCDYKMIDSDYYLPILMERYFLQSTTGSSRSESFLSTAASFFPSNSNLTYLDLAKINANKIITLAQPFTAPGNQTIDNLIHLKDGQIVGEWRDSTYGIGGGRIPLDVNSALVPAALNSIAALSTAGILSYNASMISGYAKIWEDFTLPFFEITLPQATAQDRVTRYAALAPKYNSQLTSLPAQASSIEGNVTFYALALEGNNNLSQVAVMNTDTCFRLFMLNTTNEAQLTSFLNTTADSIRRRFPAGLMTDVGMLIANPAFGEPEIYAANWTTSAYHGTVVWSWQLAMMASGLQAQLGRCIPATNGLVTPEFCGTASVFENVKHAYNVLWDSIEANREHLSTEVWSWIYTADTDAFVFEDLGALPPPPGQSPTESDVVQLWSLAFLAVGRDARFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3W8</accession>
    <name>A0A3D8S3W8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_05690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3W8"/>
    <dbReference type="OrthoDB" id="3563651at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW80992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="204" mass="21165" checksum="737437D2C56EE5A4" modified="2019-01-16" version="1">MTPPVLTTIFTPPPSCSSLTYDGEIIWCGQLSSTAGDHSCYPSDFSRAWYYFYSPRVCPHGWTSAGSVSDAGALVSVSTETNALCCPSGVFIGTGPVADSNGIFCGSVLSGNVTNVLSIQKSGSTGLVTLDAATRPRLTAWADFVQVRWQSTDEPVLASVSSVGNLVGSATSSQASSRAVSSLPSNTNPPPSTAPINRPTNHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S439</accession>
    <name>A0A3D8S439_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_05638</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S439"/>
    <dbReference type="OrthoDB" id="6509908at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF234">
        <property type="entry name" value="MFS-TYPE TRANSPORTER DBAD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="136"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW80940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="24618" checksum="08F38AA8E4FF0F94" modified="2019-01-16" version="1">MSAPVVENEPGAAVLPPSKSTAMEPGAALHQPPPNGGLLAWLQVLGSFFCFMNTWGLINTFGAFQTYYSANLLAHEPESTIAWIGSIQAFLLLASTLVMGPLCDLGYTRPQFIICSVMAVFGLMMTSLCTQYWQFMLAQGICMGIGFGGVFIPAVSIPSSYFTTKRAFALGVCASGSSFDWIPMDNENYGIHHARHDTRQCLVYEGSRAAKPEEELSRSLRFHQVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S9I7</accession>
    <name>A0A3D8S9I7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S9I7"/>
    <dbReference type="OrthoDB" id="4828117at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW83019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="509" mass="55365" checksum="033C76C6E2E93BFF" modified="2019-01-16" version="1">MPNWKTYESSVRLLSAIVAAHPELKLNYQELSKCFGGDATKSAMENRFRRIKSDAQLIKASIAKGLDPIHIPIGEGDGTTHRKGGRGEISKHMGSDTTEGGIGFQFRRIKAGAKVQQAAVKAGKDPKDVDVDPKGKEISKFMGKDTTPNGIKFQMTDRFRPLAKRQSDAVAKGEDPQYLEISAKAGKEVSKCFGSDATAVAISQQFQKTFKAGAKLQLDALARGKDPKDADFENGLKGVTSSRKPQTTEVNSIARLCGSDVTPKAISEQISKVIKPRGHLLQATLDKGGDPKDLDFGTLPTYLPAASSSKTKEIAKFYPEATASALDHRFRPIKKAAAELRAAYASGGTAAVADKYGEGVTGRAVSERFFRLKKEPAWNLDLTENADGGAVRTPKKARTPKKNKVAIAEDDEDDDDENEFPSPSKKSTLNKIKNGRVSKPSPRKGTNGLSSFMSLDSDSTIKDEVGRDCMLTSFENSHSFDDDDGWAHPDPASFDNEDQYHYDEDRNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S9V1</accession>
    <name>A0A3D8S9V1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">inositol-3-phosphate synthase</fullName>
            <ecNumber evidence="6">5.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BP5796_04402</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:10716"/>
            <dbReference type="ChEBI" id="CHEBI:58401"/>
            <dbReference type="ChEBI" id="CHEBI:61548"/>
            <dbReference type="EC" id="5.5.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the myo-inositol 1-phosphate synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.5.1.4" evidence="6"/>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW82911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S9V1"/>
    <dbReference type="OrthoDB" id="2887at2759"/>
    <dbReference type="UniPathway" id="UPA00823">
        <property type="reaction ID" value="UER00787"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004512">
        <property type="term" value="F:inositol-3-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006021">
        <property type="term" value="P:inositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000069">
        <property type="entry name" value="Inositol-3-phosphate synthase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000204">
        <property type="entry name" value="Inositol-3-phosphate synthase 1-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002587">
        <property type="entry name" value="Myo-inos-1-P_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013021">
        <property type="entry name" value="Myo-inos-1-P_Synthase_GAPDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11510">
        <property type="entry name" value="MYO-INOSITOL-1 PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01658">
        <property type="entry name" value="Inos-1-P_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07994">
        <property type="entry name" value="NAD_binding_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015578">
        <property type="entry name" value="Myoinos-ppht_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0398">Inositol biosynthesis</keyword>
    <keyword evidence="13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="12" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="14" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myo-inositol-1-phosphate synthase GAPDH-like" evidence="15">
        <location>
            <begin position="329"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDW82911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="536" mass="58650" checksum="1A407995DCC081AC" modified="2019-01-16" version="1">MAPHADIGPGSSNEVAATAHKDLFTVNSPNVVYNANEIRSKYTYRTTLVSQNADGKYVATPKETVYDFKVERKIPKTGMMLVGWGGNNGTTVTAGIIANRRGLKWDTREGSRAANYYGSVVMGSTMKLGTDAKTAKDVNIPFHDVLPMVHPNDLVIGGWDISGMNLSAAMDRAAVLEPTLKMQVHKEMAAMVPLPSIYYPDFIAANQEDRADNLIAGSKACLEHVEKIRKDIRDFKAVNNLEKIIVQWTANTERFAEIIPGVNDTADNLMKAIESGHEEVSPSTVFAVACILENTPFINGSPQNTFVPGAIQLAEKHNAFIGGDDFKSGQTKMKSALVDFLISAGIKLTSIASYNHLGNNDGKNLSSQRQFRSKEISKSNVVDDMVEANTVLYKKGEHPDHTVVIKYMPAVGDNKRALDEYYAEIFMGGHQTISLFNVCEDSLLASPLIIDLVLIAEMMTRIQWKSSSSDGAATKDFKNFHSVLSILSYMLKAPLTPPGTPVINALAKQRGALTNIFRACVGLEPESDMTLEHKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAK8</accession>
    <name>A0A3D8SAK8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_04856</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAK8"/>
    <dbReference type="OrthoDB" id="259769at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.10:FF:000009">
        <property type="entry name" value="DNA-directed RNA polymerases I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00192">
        <property type="entry name" value="RNApol_arch_Rpo6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020708">
        <property type="entry name" value="DNA-dir_RNA_polK_14-18kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028363">
        <property type="entry name" value="RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002208">
        <property type="entry name" value="PRK01099.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500154">
        <property type="entry name" value="RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000778">
        <property type="entry name" value="RpoK/RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="RPB6/omega subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01111">
        <property type="entry name" value="RNA_POL_K_14KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="74"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW83365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="164" mass="18325" checksum="11649AF3E408F9F1" modified="2019-01-16" version="1">MSDFGDDDNGGFSPTYENEEPEYDPDEPVEPFEGETNGQVDDLAVGQNPDQLLTHGERGVVVSGDPAAAANRGKAAEKAPKDKKIPSDQRTTTPYMTKYERARILGTRALQISMNAPVLVDLEGETDPLQIAIKELREKKIPLIVRRYMPDGWYEDWTCEELLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAU6</accession>
    <name>A0A3D8SAU6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase-9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_04917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAU6"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF50">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="2">
        <location>
            <begin position="240"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="56"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW83426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="556" mass="61698" checksum="D6B5E4455343F8AF" modified="2019-01-16" version="1">MAEAAFFYNFTTQRPDRSKPPSAHTNISVHSQAQPLKPKFRKRPSIDRGERRPETSSSSSSRASQSSHSNATTSFPDTIRDTALSQDRMISSPLIDYKLSANQPSKTKAAAAVAATGKTKPPISGNNPERKYATQTAEQRSAATTRGDMAGRSSSISSATGSSGLTAVTSSDPPPSDRLLARPFSRRNGRKHLRDATLPYPLPCDLAELHRQTMRTMLLCQVFNGPVCSPAFQITPPKRVLEVACGTGFWSVMCHRHFAQRGFSSIEFTGVDIAPLAPKMDMNDDMIWRFVQHDLRRAPFPFSDEEFDLIMAKDLSMTTPTIGMQQSLMDEYLRILKPGGTLEIWDGDHSLRMLLPHAQPPTRENEDGDENEEQVHTNAMGTYTITPQTPFAAPQNQFLLDYNSWITKALDLRKLSPMPCTMVRPMLLQEAEGLADIDSRRLAIPLGEVRWEREGVGGVVSGNELSNALSSKGKGKDQDRRMLTPGQSALRRTALMNVVQMIESLEPLLREASGKGQDEWDRWQGNMMNDLLKNHGASWGECLEVGAWWARKKSPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SGI9</accession>
    <name>A0A3D8SGI9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_03775</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SGI9"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43812">
        <property type="entry name" value="BLR2425 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43812:SF2">
        <property type="entry name" value="FLAVIN REDUCTASE LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00903">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="2">
        <location>
            <begin position="25"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW85450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="268" mass="29858" checksum="BCE27C43CADCA310" modified="2019-01-16" version="1">MVHESIFYQPPKGEKSGLPHDPFKSYVIPRPIGWISTKSRDGQDNLAPFSQFTNVSFDPPTIMFVGHQSLYKRRSKDTVMNCIETNEFVWNMATYELKDSINSSALESWGDEFEESKIEKAECKLVRPPRVAKSPVSFECRVHTILRVPNESHGEAMFGPHLVGTSDIVIGRVLGIHINGEYITSDGLFDVLKAAPVARNGYHQFTHITQVWDMAMPIMSDDNVSGGVLGGDVDYDAPNKEVEGSAPESPVEKVISKKVRSSRTAFPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SGX6</accession>
    <name>A0A3D8SGX6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_03847</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SGX6"/>
    <dbReference type="OrthoDB" id="3862662at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW85522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="516" mass="57492" checksum="EA59AA9F33A5ACC6" modified="2019-01-16" version="1">MAILGAQPEYNGFALTACVNCRRQKKKCDKHLPSCSRCVGGLRTCQYSQDQDKLPSPPYDAVKDCSRPRYVVASSQPSLSISPASSTTGSLPMNTRSFLLPKEIHVRDIHALVTSYVHDLLLSEGQTANHVAAEYFTLTCHWLPFISRMKMHANLRPTIVERRADVMLLLLAMYLSIQVPGPAVEGTGMRTPLYLKTKELLALVQSGDILSIETAQATILIAFYEYAHDLSNASYQSISSCAVMAYQLGWYDQAANAQRSPSDFEEIKRTWWSIAAFDRLIQVRHINSGFPCAIPSSRLEFELPVEDERWDLFPDNPQSPYLISGTAVLQARATQAISRTIEFVKNPPSDADIKEAQLRELSEALISLAISTVERSFAIFGAHCGAIDSSLNVLHTPDLPAELTPLAEYTPSNSRATFALKKMCNNTTSTVREIFIAIKQLDLRNLIPITLDSIVRSTLIHIQLAGSEFGSVDWERDFIDLKGCLAHFGKRFLLARKFLDDVNNAYNARLQREQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SH20</accession>
    <name>A0A3D8SH20_9HELO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03918</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SH20"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW85593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="72" mass="7682" checksum="CCB364C11798F875" modified="2019-01-16" version="1">MWSAALCQSIHHGQNPLSENAPCLATVTAKGTTKPNEAAQPRSALNPISWQTPRAWRDREESIAAGTAADVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SI20</accession>
    <name>A0A3D8SI20_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_03743</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
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        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
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        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
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        <property type="entry name" value="PROTEIN VAPYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
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    </dbReference>
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        <property type="entry name" value="Ank"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="6"/>
    </dbReference>
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        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
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        <property type="entry name" value="ANK"/>
        <property type="match status" value="23"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="16"/>
    </dbReference>
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        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="17"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="495"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
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        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="595"/>
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        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="629"/>
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        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
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        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
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            <end position="731"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
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        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="768"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="800"/>
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        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="833"/>
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        </location>
    </feature>
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        </location>
    </feature>
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        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="932"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1061"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1185"/>
            <end position="1217"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1218"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1251"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW85418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1310" mass="140879" checksum="A3A4F5A04C9DCE24" modified="2019-01-16" version="1">MESDQASKLSRAPSTPRPYRAKVEDTGFTTLYDGSGYDGEDGLVDIILVHGLGGHPEQTWSTASLSAQSQQTSSGSDQRLSRDWISTSRGIQGETFWPADFLPLDFPRARILSWGYDSNVERFFSGAAEKGMYYSHAKDLLSDLSDIRARDVVSPPNTHKRQSNLLTKQQRRRPVIWITHGLGCIIIQEALLHAHSDMREDIPNHLQEIYGATSGVVCLVAPYFKSTASEWESMTARFVEAAGVDANTGMLKQLTAQSPELASVQQQFSDLIKNSDFQFRTFDEGRSMEGLRGLNSKVIDNVSSTIGGFNSRTIQANHMESCRFSHPADIGYCRIKEDLNEFIDQIQTLAKESPLQERTILLEDEMVTLFSVANSSFRALNVACGDFLAADRGKGLARNPPQYAKSVTTVPPQHLGLLRKPITENDVGRDYDLHDVIKMGDVTRTHGLLAKGSEINEIDPKFITDLSLAISSGKVEDVDLLLTKGAKIERRHPYSMETPLMEAIRLKSHTIVDMLLQRGADSQATNRYGQTPLEIACGVGDKRTVDLILGAGKASNKQYPGFMSMPLILATKSNHSEIVDMLIQSGADIEAKDMDGQTSLHIASGSANNRVVEVLLRNGANIEAKEPGQSRTPLHCAAEYGNAAVVSLLISKGAIVDVPEYKSGKTALHLASENGHDAVVDLLIRTGADVSAKQYPKIEGKTPLHVAAQNGHVPVLELLCAKASKDAVNEKEIFDGNTPLLLAARGGHSLAVTWLLKMGADIEATSYTGSTAFYLAVKQGHEEVALSLLREGASVEWPDAASTPLQYAAFLGLVTVAQKLIALGADVQETNENGDTALHRASSAGRIACVSLLLDNKADLNAKNDFGYTALHQAARNGHRDVVRLLLTRGADLRISDKLGMNALHNAVSQGHEEVVKLLIAKGADLTLADQKSMTPLHLAAAAGYANITLLLLRSGAATDALALNRQTPLGLACLNGQESTAMVLINNGTRLAASGIGPPLVAAATGGHLGLVNLLLSRSDDDGTIGETAALLAAAQNGHAAVIKRLLETGEFDIDESGEDGLSALHLAATNGHVAAIQVLLEEGADIDQESYIEWPPICGAALNGHASAIRILLKAGSDIGCLQDIFSEDISSLQESDPEGLVRVFVENAEATKQFYMSIKDGDIPSIREQAAERAVTKMRDAHGNTPLHIAVANGHTKAISILCEMGVDVNTGNYRKQTALHEAVMRRHIDALLLLLHYGADVNAQSARGATALHGAVYSKQETAVRILLEAGADVSIKLSGLTALQHAERMGQKANVQLLSDRVVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SI49</accession>
    <name>A0A3D8SI49_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_04311</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SI49"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045016">
        <property type="term" value="P:mitochondrial magnesium ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd12823">
        <property type="entry name" value="Mrs2_Mfm1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039204">
        <property type="entry name" value="MRS2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890:SF0">
        <property type="entry name" value="MAGNESIUM TRANSPORTER MRS2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890">
        <property type="entry name" value="RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22099">
        <property type="entry name" value="MRS2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="756"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="789"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="12">
        <location>
            <begin position="225"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="464"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="465"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW85986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="842" mass="93942" checksum="4830756881A3C70D" modified="2019-01-16" version="1">MPSQTTTTTKAGRKILKLDSSNGQAYREISTAAPRAASAEEIPVIDISKITSPKLEDRMSIALQIKPAAEDSGFFYIKNHGVEEQTISNAKAAAVKFMAEPMEVKQKIARNKQKYWNGYCGPEGSQANKTESRDYKEGFGWQYSPDFDPLYDYLPKPIPLSSIPADTREFSRAEHHIWDGTLTVPGFKEDAITYYRSMLNLARHLTKVFALALDLKEDYFDALTTYPGADLAFNYYNPVGPEVGGVSGDEVMSHEVGLGSHTDLQCFTILWQDMIGGLLILNRIGEWIKATPIEGTFVVNIGDFLMRMTNDKWLSTVHRVEVNRSAEPRISMPLFFGFNFNEVIGVLPSCVSEENPAKYEPLRVGDEPRSFTNVIHNSFKSCRVDHSGCDEVIIALLPRLCQRDNLSLLHEPIIMHASSQGESESPADQCREIEDPSTVVTMSMDDKGKAQTILDNLCGIFNERLSPDPDTKPIGRDQPQDGASSPEKLPLLQKLDSSEQSTASEPQKDSSLESDTPENKPFTVDSSLAARLSTDRKLQCTSFDAEAILVRRSTILVNLLQHRALITHDNVLTLHVDGPYTNANHDSAFRHGLQGKLDAGISQHENLPYELRALETILIMVISELDTEYQELKKPADHVLEELGRDVDLEKLKKLLDVSKQVSAFRQKVKLVRSALHTLLDADDDMAAMYLSEKAAGKPRAEADHEEVEMLLENYYDASGEIVERSDKLLSDVEYTHDSVRSILDSHRNSIMMLEVHFSVAMLGMATGTYVAGLYGMNLINGLEDAEHGFSFITSCSTMGILGVGLWGLLKLRRIKRIYNFPRTQHSRERVKRAAATDAVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SLZ5</accession>
    <name>A0A3D8SLZ5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_02990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SLZ5"/>
    <dbReference type="OrthoDB" id="48988at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19075">
        <property type="entry name" value="AKR_AKR7A1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW87296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="313" mass="34268" checksum="1364D6FC3B7DA763" modified="2019-01-16" version="1">MVKIIVGMMGSSVASGSAQMAEVSQVSSFLEAVKAHKVHELDTARVYNDGRSEELLGLSNAQQDFAISTKAPAFAPGSLAYDKIIENCGKSMKALKQEKVDIYYLHGPDRTTPLAEQCRAIGELYKLGRFERFGVSNIKDAEVQEIYDICKREGYCMPKVYQGGFSPLHQKAKNTLLPLLKKLDMDFYAFSPLAGGLLAKPIDQLLKPAKGSRFDAMPVFGDMFLTETIVAALKSHTALCEKNGMSLMEATMRWFMHHSPLGDKDGMILGASSTSQIEATLAATEKGPLPDEVVKGWVDLWDTIEEKAPGYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SN28</accession>
    <name>A0A3D8SN28_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03433</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SN28"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021838">
        <property type="entry name" value="DUF3431"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF3">
        <property type="entry name" value="DUF3431 DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11913">
        <property type="entry name" value="DUF3431"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW87739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="424" mass="49510" checksum="4392B196D3F52BD0" modified="2019-01-16" version="1">MFVGAFLFSTREIIHETPLEVIQQHVIKQSGGVYRIPDGPPPTVHLVVAATSTEDTSWLTELRVPGMETIIYIADNKSAPHHAQENKGHEAMMYHQYFYDYYDKLADISILIHSQKMAWHVEQLLDQSMLFSLNHMDMREIQRRRFLNLRVTWGVGCSSGQINTTKVNEESGSIPEQKEMQEAFRANFNIYDIPEILATPCCSQIAVVKELVRSRPREQYKHHIQWLLDTKLDDSISGRTWEHMWQYLFLKKAVDCPIEHRAYCRLYHICFGGREQYDEWIELQQGAQRLRDEIHKLDQKKRALDEKSRRNEDEEKRRQEEHKDSELDETEQRQEAARKKQEKARADVQAKADQKKRQWLEEELSTVDEAIRVRKEVAMVRGSVEANRIAEGEDIYGDALEPGLEFTSSLSATPMPTPDRSREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SNC3</accession>
    <name>A0A3D8SNC3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">MFS sugar transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_03375</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SNC3"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010255">
        <property type="term" value="P:glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000115">
        <property type="entry name" value="High-affinity glucose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF40">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="283"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="318"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="377"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="23"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="514"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="529"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW87681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="565" mass="61668" checksum="C1401A9959559927" modified="2019-01-16" version="1">MVYGVIWQKPDNVAGSSAPAIMVGLFVACGGLLFGYDTGTISGIQAMNAFQEQFSTGYVDIHDHERTITPAQASQVVAILSAGTFFGALMAAPMGDSRLGRRSSLMVAVGIFSFGVLLQTLAMALPLLIAGRFFAGVGVGIISVLVPVYQSEMAPKWIRGTLVCAYQLAITSGLLLAAIVNISTESLQSHNAFRIPLALQFVWAAVLLFGLALLPETPRYLVKRGLKSAAASSLSRLRRLDITHPALAEELAEIEANHEYELSLGPSSYRDVFLGSPHLGRRLLTGCCLQMLQQLTGCNFVFYYGTTFFKNIGITSSFVIQLIINLVNVFSTIPGMFLVEAWGRRRLLIVGAAGMACCQFIVGALGTALEPSREVKILLIFFVCLSIFFFASTWGPVVWVVTSEIYPLKVRAKSMSISTASNWLLNFAIAYGTPYLVGSGQGYANLQSKVFFVWAAFCVLAIVFVWAMVYETSKISLEQIDELYERVDHAWHSRNFQPSWSFQDMRDEGAAASGIQLEEQDSEARRRTTSSTSANLSESSTHSSTHTMSEEDKIIAQLGDVDLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SQ45</accession>
    <name>A0A3D8SQ45_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_03612</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SQ45"/>
    <dbReference type="OrthoDB" id="47494at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF5">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="140"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW87918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="402" mass="42671" checksum="CD24A10DD6977F84" modified="2019-01-16" version="1">MAQKPVLISGAGLASLLLAQSLRRAAIPFLLFERDASLSFRAQGYRLRLSSEGLDAIESVLGPKDFQTFWDKCGKTGGSGFASLDANTGLTLSEASKDVKAEEAKPKVPTEALASRDGKIVGISRGDMRKLFLTGCEPFIHWAHHVTGYELTASGVHAIFADGSKSVEGQMLVGGEGIYSKVAKQLSQGKLKVYDTGARGIHGQAPTTAFNGLGEGVWRLTDDSNPVGRVFAITNVRPGEMDDPNLHFGWTMGAQPGVIQPQNDDFSMIGAPAAEIAKSLTANWHPRIRPLFEEMVESEAAFWKITCSTPSGVPEWPNEPRVTVIGDAVHSMTPAGGIGANTAVRDSALLGRLISEAGGCKDGVTAAYEKDMRVYASEAVKTSYGLATGQFGVVINENSATV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYD7</accession>
    <name>A0A3D8SYD7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ORP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02449</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYD7"/>
    <dbReference type="OrthoDB" id="4161595at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="430"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="643"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="679"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="712"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="789"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="689"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="834" mass="93298" checksum="C01FF05A843CE371" modified="2019-01-16" version="1">MDVTSLLNGNAAAGQQKVEDQAEKMEIQRKPSTSPPRNRTPWDAGGYSLPINTVSNQSISAAQSGQSGDLNSNEDIPHSPKHKFSDSRSSLSSFTSSQHSAGHSRFSSMSTVGSSHPAAVDKVSGESRRGTPQPQSLGSPIDNSVIEPRLRSSLSPTGSLDALAVAAERRQSREEQLSPMQQTTEAMEATNITPTKERAHGRPGSPSDAILIKRASVPSLRLNTEELVDSADKQTSMYLSAPLEHQGHPTYNGGHRHKRAVSAPDFPPTVITEFAARRGSSVMIGGHAEPTPPPSHHPDHHSPPAPIRYNAPDTPPTTTAEMENQQVICMYIPNCDTGSQPRKAISHIFGRNKMCTRLIPQQVWVHYCRKHYQRSRYRNPKEYAKLQCDLVQQQIRRVHAWSEENRQRGEAGVVENWGLAVRKREQKRLDDLGGANRKRRASAFDRNDSDEGDNGDDARGNPVPATAVPQWLLEQCQKGYSTEEILHIFSRLHREILEDSMPCFPDIEILPNIVVDQEEEPKADAKGFSKRKPFANAHKRSQSLGVAMKPGQFYQQPMVGRRMSQPVVWQPQDMYANSPIQKRRRATEEDYAEQQMPPFQRQRMMERPVEAGRRLQGLVHRPVFANIEEHQVDENDYREVQGRGSYFTHSPSPAYRAPLPAPTPQRLHNPSMAAHLETTNEPARRPMHQRSQSDMGFSQRGQVAYGQPTSVYTQSPAYQPHAAPVQQRHEQPGGYSPYAQPQQVVPRYHEAPVRQHPYADPRQLRPMSGPGHARHQSTPMMIPQHVHQAQPMAYGREAPPPHPSYAYSQGHAGNLPPPRMENQHPQGVYATARR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYT3</accession>
    <name>A0A3D8SYT3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7598 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_02619</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYT3"/>
    <dbReference type="OrthoDB" id="5327148at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056019">
        <property type="entry name" value="DUF7598"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24535">
        <property type="entry name" value="DUF7598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="26"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="56"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7598" evidence="3">
        <location>
            <begin position="17"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW91454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="327" mass="36532" checksum="E6731ACBAA036ADE" modified="2019-01-16" version="1">MFAFDSFNAAHKLAGPGYIILNVIRVLNIIVLLLIAIASWVMLVMTFFFFDGVSHFITSLISLFLIVSELSLFPDYFLRYWPLLGLESGLVFLGSAMVVLGFNTMGNLNKTATSIENLGLPLWRLVLASGILATIMGVANIVATIVLCDSAQGITGRQVRSRGATAMNEKLEPSLSRNYSRNSFRPGTRTSDLPSYNTQDRRRSKFGFKFPIRIAGLSRPTANEPEQSKWASRFSRAPVEISGPIPTDNDQFSKWESRTSPVAPEIERPPTALHPAYSPASRYSERNYEMTGPFEYGVWESGVNFFYTRHYDGDDVGDGNRGRRRES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZ89</accession>
    <name>A0A3D8SZ89_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_02646</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZ89"/>
    <dbReference type="OrthoDB" id="397265at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd22385">
        <property type="entry name" value="KH-I_KHDC4_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22386">
        <property type="entry name" value="KH-I_KHDC4_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000037">
        <property type="entry name" value="KH domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000051">
        <property type="entry name" value="Putative kh domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047890">
        <property type="entry name" value="KHDC4_KH-I_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047889">
        <property type="entry name" value="KHDC4_KH-I_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056149">
        <property type="entry name" value="PRP5/DDX46/KHDC4_KH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031121">
        <property type="entry name" value="RIK/BLOM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15744">
        <property type="entry name" value="BLOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15744:SF0">
        <property type="entry name" value="KH HOMOLOGY DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23469">
        <property type="entry name" value="KH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="240"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="441"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="377"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="441"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="453"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW91481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="482" mass="51839" checksum="C6A84E6D2A5DA3EF" modified="2019-01-16" version="1">MDDTERRTAKRSRFDQKEPEPKRASRFDRRSRSPPAHKPEYRRSRSPVAQGSRSPAPESVPKSALDPAAAAAAAAAKINAQLQAKKGIQHVDVPPIRATSENYTPGKSASPGASGAAGNSASAINGEMYIADGDYIKDIEVNDLRNRYTLTKGSTQKMIKEETGADVTTRGNYYPDKSMATAANPPLYLHVTSTSKKGLEEAIQKIEELMKQELPNLVDERRFRRREPEQVERDEFGRRKWPEEKIPIDFEPIPGFNLRAQVVGHGGAYVKHIQQETRCRVQIKGRGSGFMEHGTGRESDEDMYLHVAGPDPNEVQKAKELCEDLLKNVREQYEEHKNRPQQRGYGASTGYGGERGYGDRAPDRSNSYGGGYGGYGNSPAPSAPGGAMSPSTPSAPGAGSPSSAADPYAAYYASIGQPDPYAAYGGYAAYAQYYQQYMAAAQAAQQAPGAPGSAPPPPPSEAPPAPPGGSGSYGAVPPPPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZ90</accession>
    <name>A0A3D8SZ90_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02765</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZ90"/>
    <dbReference type="OrthoDB" id="10353970at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="101" mass="11353" checksum="D9F6831EC456B418" modified="2019-01-16" version="1">MRFVEAVGIQDAEQDQGHARHDAGHNSEPRDSPGERRVFQPVHPGGVAREMHRADSANEADRRQDPADEEHRLQRKGTDVRDEPVKGSQRRVGTLAILTRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZA0</accession>
    <name>A0A3D8SZA0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_02818</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZA0"/>
    <dbReference type="OrthoDB" id="5667at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17352">
        <property type="entry name" value="MFS_MCT_SLC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050327">
        <property type="entry name" value="Proton-linked_MCT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360:SF224">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11360">
        <property type="entry name" value="MONOCARBOXYLATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="54"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW91653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="443" mass="47456" checksum="B541F6B2E3B42836" modified="2019-01-16" version="1">MTKEALDPEAGGITEGGGTQASSITAFVQKPSEAPTSIEQIDSVPDGGLRAWLVVLGAWCGLFCSFGWLNSIGIFQSYYETSLLPQYSASTIAWIPSLEIFFTFAMSPVIGRLYDSFGPRYIILGGSFLHVFGLMMASISSEYYQLLLSQGVCSAMGICAIFQPSVSTIPSWFQRNRGAAYGIISSGTSLGGVVFPIMVSQLIRRVGYAWSMRISAFLILVLLVIVNLTVKSRVPPQPQHMSRGTLLQPFREVPMVLLLVGFFFLTFGVFIPINYLVIQAIDEGMSDSLAQYLIALLNAASLFGRIIAGILSDRIGTYNILVTACYLAGVLSLALWIPATSNAGIIMFSILFGFASGAYVALAAALVVRISPSPEIGYRTGILFLVGSVSGITASPIAGAILQSRGGSYIGMQVFSGITLLVGTTFVFGTRLYKTGLVLRAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZI5</accession>
    <name>A0A3D8SZI5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ethanolamine-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="10">2.7.7.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CTP:phosphoethanolamine cytidylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_02343</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.14" evidence="10"/>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZI5"/>
    <dbReference type="OrthoDB" id="40021at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004306">
        <property type="term" value="F:ethanolamine-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044608">
        <property type="entry name" value="Ect1/PCYT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780:SF2">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="13">
        <location>
            <begin position="27"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="420"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW91178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="446" mass="49942" checksum="7904E8B441B30FC5" modified="2019-01-16" version="1">MSLATQYESDGPPGEAAPEILEKRIWVDGCWDFFHHGHAGAMLQARQLGDELFVGIHSDESILENKGPTVMTLKERIAAVDACRWVTQSVPYAPYVTSLPWISHYGCKDVVHGDDITSDSSGEDCYRFVKAAGRFKVVKRTPSISTTDLVGRMLLCTRTHFIKSLSKVLEGLEGSGTADERKSEGQAMSERVRLYATDETGLNPGSSVWFWTASLEAREDDTEEEKGVFSSLCQGSRPKPGQRVVYVDGGFDLFSSGHIEFLRQVIKAEETIGEQEGWYSEQATQERVGKGGDYGPVFVVAGVHDDEVINHWKGVNYPIMNIYERGLCVLQCKYVDSVIFGAPFTSTRAYLSSMPWGTPDAVYHGPTSFMPLTYDPYTAPKEMGIYREIGKHDFANVNAGQIVQRILKSRDMYEERQRVKGVKGIGEEAQRRREKMEEEQRIRESG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T005</accession>
    <name>A0A3D8T005_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase C45 hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_01301</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T005"/>
    <dbReference type="OrthoDB" id="189997at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.60.10">
        <property type="entry name" value="Penicillin V Acylase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047794">
        <property type="entry name" value="C45_proenzyme-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047801">
        <property type="entry name" value="Peptidase_C45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005079">
        <property type="entry name" value="Peptidase_C45_hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040521">
        <property type="entry name" value="C45_proenzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34180:SF1">
        <property type="entry name" value="BETA-ALANYL-DOPAMINE_CARCININE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34180">
        <property type="entry name" value="PEPTIDASE C45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03417">
        <property type="entry name" value="AAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C45 hydrolase" evidence="1">
        <location>
            <begin position="107"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="347" mass="37676" checksum="34683267C42F99DA" modified="2019-01-16" version="1">MLQEIHCAGTPREIGFKHGSEAKAKIQGTLSFYREYFMRKANLDWDAACLNAEKFMPLLTRDWSSLVEEMEGVAEGSGLSFSSILAINVRTEISMGMMTDGCTALAWKTDSEALLAQNWDWEVPQQANLIALHIHRQAPQTSISQVTEAGIIGKIGLNSSGVGVCLNAIRARGISYSRLPAHLALRVGLDSTSRSEAVERLEKAGLGAAAHILIADETGGTSMEFSALDLVKFEMRDGKVAHTNHFLVQHAEGVADATFLPDSKERMQRITELMARETTAGVPSVQKMLQDEMNLPGAINRVASEKSPSATLFSIVMDLKARKAMVKVGRPTECEDTLVLDAGSVGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T200</accession>
    <name>A0A3D8T200_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_01845</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T200"/>
    <dbReference type="OrthoDB" id="5417386at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="485"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="559"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW92451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="724" mass="79838" checksum="CC439E8DC0EBF2DF" modified="2019-01-16" version="1">MITSVRSVTPRLVTVRRPSNKSNGAVYVDREVVVVSTAADDPTERSAMYSTTPSSSDINEAKSDPREPSSYLRTSVFAQHMDVDRPASGSNHPRSSIRSFRRTSTRDVVLSENNRQSMKELANFLRTREPPPDHYMSIPESRELPSVRKRSSFNLFRRRKSQQPQGPKLLQLPDSAIASKTSGGHRHIAISIPIEHEYVASPSRNKSSGGSYADRLGGRNGLLLNPVRSFELPSPAQRRTPNVAGSSNLTETISIPNGGKTEFERHAHPQCTCPPKRGSMLLENPSLGTGPVVDPGVEFSPRSSVNKGLRHSIGPIYIDKSLPPPPHESRPTSTVPSLRSTYRYSLPPRTSSKGSARKPFSDTAAASNVQRVSGHKPTISGASAMSGGAESLDSIGSLHTAGVVDLQNFVGNNLRVRTKSNSSDHVGMYIVRPSTAPSTAPPERQLQAVTDMKKAEPNRSPTSIDSREMQLILASRQCRQERVRAKKQRDIEAHKEHGRSEPTQSENGLRPNAVRILTRSSSSLTRELGVKKRNANAITPIMVVAAVEPTFDYKAVSRNRSIKRRADPPLSHTPPRSSTSQASDEDTIARQPRKSMAIGSVATRARLSRRNSILSQHHKIAQEREADLDLRLSRIERDNTILLHTLNTLSRSFLNMNRLLVPSSRRENTKRPVLHDIGSTMGKEPAPVAGLDSIEPLMRELQDNARVSREEGRFMGPDEVEDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T259</accession>
    <name>A0A3D8T259_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-polygalacturonase</fullName>
            <ecNumber evidence="3">3.2.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BP5796_01983</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(1,4-alpha-D-galacturonosyl)n+m + H2O = (1,4-alpha-D-galacturonosyl)n + (1,4-alpha-D-galacturonosyl)m.</text>
            <dbReference type="EC" id="3.2.1.15"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.15" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T259"/>
    <dbReference type="OrthoDB" id="1546079at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000002">
        <property type="entry name" value="Endopolygalacturonase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050434">
        <property type="entry name" value="Glycosyl_hydrlase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884:SF1">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017586846" description="endo-polygalacturonase" evidence="14">
        <location>
            <begin position="20"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDW92589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="378" mass="38054" checksum="AFE0A8BDFAD089B2" modified="2019-01-16" version="1">MVSFSSAVALLATAGIALAAPAPLPTAAAKLEDRATTCTFTNAASVSKSKTSCATIVLDNIAVPSGTSLDLSGLTKGTHVIFEGTTSFGYEEWSGPLVKIGGTDITVTAASGAYLKGDGARWWDGKGSNGGKTKPNFFAIEKLISSTITGLYFQNSPRQVMSINDATTVTIADITIDNSAGNTGDTSTAATNTDAFDIASSTGVTITGANVSNQDDCLAINSGTDITFTKSTCTGGHGLSIGSVGGRTDNTVKSITISSSTVTNSQNAVRVKTNSGTTGTVSDVTYSDISFSGITKYGIVVEQDYLNGGATGTPTSGVPITGLTLSNVKGTVTSSGTNVYLLCASGACSSWKWTSVSATGGKTSTKCKNIPSGSGASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T262</accession>
    <name>A0A3D8T262_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_02018</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T262"/>
    <dbReference type="OrthoDB" id="2991872at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW92624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="506" mass="55616" checksum="E7A98701052259E4" modified="2019-01-16" version="1">MANITCNAVDVASDFIFLNENEYVGGQRKRPRGPNVNKSAGTRDISQAALMRPTNRPNISLPPVLAPLLNDLALAYYSHYYVEVPRSLPEIIAGHMKYSRADICYTHPESILSLAIFAVSYATFGRAQKNSVALAAAASQYSKALVKTNAALMHTSEATNDEVFLAAMLLSFYENSVMDNTSLFSGQDIQATASRSFAHHDGAMAMLKMRRQLKDRTESSMELDKLVRRQLIRSLILRNLPVPSWLRDGSQYGETDFALKLDRCTIIVAKIRHQAASFSGELASPFAPGSPYELANIQSLLAEAQALDNCLIAWARELPIESLYTTHTLQESGISEKDSRIFNSTVHIYPNVGHAGMWNRYRALRLIVNDIILKALSSLVRFPGFDAASQLIATKLKIEKVANAFCASVPYMLELFEIQQSGDNDMALAIKAPASLKISVRGTTASLLCWPLTIATTVSGIPGSQQRYLRDRLLDVSEIVDDGVLERIAASFSPSCCSANIQEVSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T2H9</accession>
    <name>A0A3D8T2H9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_02035</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T2H9"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF8">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW92641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="31788" checksum="D7E5769F02A94E1E" modified="2019-01-16" version="1">MPRPVSRPVFVIVPGASQTPSHYAHLIHLLQSHGYPTLSSMLPSTGTGANVTVQDDADYIRSRMILPVLEIEKHDVVLIMHSYRHDFPFLLNFLLLFGVFYDHLSLPLFTEQQLTPNSGLPGSAAALGLGKEDRAKEGKSTSVLGQIFISSMLVKGGDGKDVVATFGGQLPPHLIVNEAAGLIECEDPAPVLLGDVASQAESDALVLSSLCPSLASFTSPCPTASWDSPAFKGRLAFIRTLKDLTIPPVVQDMMIAGTGQEFVVKDLDVGHNAQIVAPEDVRQILIELAKKFEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T774</accession>
    <name>A0A3D8T774_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 15">Dipeptidyl peptidase 3</fullName>
            <ecNumber evidence="4 15">3.4.14.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13 15">Dipeptidyl aminopeptidase III</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14 15">Dipeptidyl peptidase III</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BP5796_00170</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity. Also acts on dipeptidyl 2-naphthylamides.</text>
            <dbReference type="EC" id="3.4.14.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15 17">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15 17">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M49 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.4" evidence="4 15"/>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T774"/>
    <dbReference type="OrthoDB" id="4694525at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008235">
        <property type="term" value="F:metalloexopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000001">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000002">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.540.30:FF:000004">
        <property type="entry name" value="Dipeptidyl peptidase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.30">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005317">
        <property type="entry name" value="Dipeptidyl-peptase3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039461">
        <property type="entry name" value="Peptidase_M49"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422:SF11">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23422">
        <property type="entry name" value="DIPEPTIDYL PEPTIDASE III-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03571">
        <property type="entry name" value="Peptidase_M49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007828">
        <property type="entry name" value="Dipeptidyl-peptidase_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="7 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 15 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 15 17" id="KW-0862">Zinc</keyword>
    <feature type="active site" evidence="16">
        <location>
            <position position="448"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="447"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="452"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="506"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRNR" id="PIRNR007828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR007828-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDW94407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="707" mass="78860" checksum="01E6783CE812B81F" modified="2019-01-16" version="1">MNAQELKNFLADSPPSTVNLEIKKHFDALTDQEKRYAHFISKAAFAGTRITLRQVSPESTDIYDFIISLYKSCDGDWASLQKKAEITEQELNSFLEYSTQFLGNAGNYKGFGDAKFVPRCEEKAFTALAATSPEADKYYKATKGAIFSSNNAGIMHLGYLDEGHMTTYYPDSPAITKADISAVSDFLEQKKLLIENTRLRKTADGNFELLIASAVTKIPENGGDLGKATEFEIDSGPLKGHKLKLVYGDHSKEMSRIAEFHRNAAKEAANENQKKMQLAYAESFETGSQETWKNSQRFWIKDQKPTVESNIGFVETYRDPHGVRGEWEGFAATVNLERTKAFGGLVDSAQEMIPKLPWSKDFEKDKFLSPDFTSLEVLSFAGSGIPAGINIPNYDDIRQSEGFKNVSLGNVLSAKAPNEKIPFIAESDLALYQKHRDAAFEVQVGIHELLGHGTGKLLQETKPGVYNFDNKNPPISPVSGKPVTTWYKEGQTWGSVFGSIASSYEECRAECVAMALSCDFEILKIFGFGDGTADMDGEAGDVLYAAYLSMARAGIASLEMWDPKSRKWGQAHSQARFSILQCFLSAGPDFCKLSYEKEDLSDLTILLDRSKITTVGRKVVEDYLQKLHVYKSTADLEAGTKLYKQMTDVDADYWGGKVRNEVLRNKQPRKVFVQANTFLDEKTGKVELKEYEPSLKGMIQSYAEREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8B2</accession>
    <name>A0A3D8T8B2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AdoMet-dependent rRNA methyltransferase SPB1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_00576</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8B2"/>
    <dbReference type="OrthoDB" id="1287559at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000004">
        <property type="entry name" value="AdoMet-dependent rRNA methyltransferase SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03163">
        <property type="entry name" value="RNA_methyltr_E_SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012920">
        <property type="entry name" value="rRNA_MeTfrase_SPB1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024576">
        <property type="entry name" value="rRNA_MeTfrase_Spb1_DUF3381"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028589">
        <property type="entry name" value="SPB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF13">
        <property type="entry name" value="PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11861">
        <property type="entry name" value="DUF3381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07780">
        <property type="entry name" value="Spb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="10">
        <location>
            <begin position="24"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3381" evidence="12">
        <location>
            <begin position="234"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA methyltransferase SPB1-like C-terminal" evidence="11">
        <location>
            <begin position="623"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="365"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="442"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="600"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="764"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="457"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="512"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="607"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW94813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="836" mass="94028" checksum="B6314E22DC3DEB3F" modified="2019-01-16" version="1">MAIQKKHGKGRLDKWYKLAKEKGYRARAAFKLIQLNKKYGFLEKSKVLLDLCAAPGSWCQVAAETMPVSSLIVGVDLAPIKSIPRVITFQSDITTDKCRATIRQHLKTWKADTVLHDGAPNVGTAWVQDSFNQAELVLQSMKLATEFLVEGGTFVTKVFRSKDYNSLLWVFNQLFTKVEATKPPSSRNVSAEIFVVCQGFKAPKRIDPKFLDPRSVFAELSDPTPNNEAKVFNPEIKKRKRDGYEEGNYTQFKEVPASEFIQTTDPIAILGSLNRLSFAQPANGDVALAALDKLPETTTEIRNCCNDLRVLGRKEFRMLLKWRLKVREKFGFATKKSAKAAAEAAAEEVAEVEPMDEELKIQEELQALKDKENTRKKRERRRENEKKQKEVIRMQLHMTAPTEIGLEQAGPNGEGSMFGLKAVDKSGAVDKIAKGKMAILKESDAHKEFDFGSGGESDVDSDPEEDELDKEMDAMYEQYQERKSEADAKFRAKKARKEHEDGDWEGFSAGGSDDDDELEEDSSDDDSDEEAPSKRSLLTNLERKEQKAGGLSKRAAQFFDQDIFKDIGGVIEEVEEDEGSLDEDDQETLAAGLDELEIIRESKAGSDEEESELVEEIGAESDESEEDGFEIVKRKDQDANWEDEEPRKDGKLDIDIITAEAMTLAQQIASGEKSRYDLIDDGFNKYAFKDRDGLPEWFLDDEGRHDKPHKPISASAAAAIKEKLRALNARPIKKVREAKDRKKFKAAQRLEKLRKKSALLADEEGMTEKEKANSISKLMSKATKRKPRQEVKVVVARGGNRGIAGRPRGVKGKYKIVDARLKKDVRADKRLAKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8S0</accession>
    <name>A0A3D8T8S0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_00713</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8S0"/>
    <dbReference type="OrthoDB" id="5148443at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="575"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="626"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="660"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="702"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="732"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW94950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="793" mass="80731" checksum="6B9765275D358E19" modified="2019-01-16" version="1">MAFTQNETSLAWSFTRYGMLILVALFLFTAGLFSGRNSYNGAVQVVRPRSLDEASTINELNAIIAAHNEHLRQRDEEAQLASRSLFSALGDALQSGASSVESSISSLLPNASSLIGSLTAGINTTSLIDSLEPPANSLGVGLASGAMTALKLQIENKTAPSGIAGVAQSLGSGLTSTIFSSANITALLNSPPALSANSTVGLAALSLAQGLGGGAVSGLNINKVDMVMFNTSGLNGVVGNFGQGLAASALGSVNIKSLTSGLGSIASNMRKRATETNSTLGLGSLSNINIADIAGGFGTGLGQGAAIGLGFQADASAPSNDSSPAVVSQVFAKGLVASFLSNGTLTKAAASFTASTGNSSSSLDGNDTTASSTSSFGGISLGNINIASAAEGLAVGLVSGAASQVMSLRLISADTTSFNDTVGGAATSFGRGLGSEGAKLVSQILGTSTVATPMKHKRSLAETAGFVSFSGKSLTKREDTANATDLASVLSNLNASNINPLVQTGLNALTCEGVGGLAGIFVGLILGGTVDVNKLKFSGNLTLPDQDFFIRSGGNTYALNPSKGLTTATVNNTAIISYVILAVLHIVLAILAYFIMLPLVMLAFSCQRITKLMQSANGTTAPLPKWIVLVGYAILPLSLTVFILGIAFRASAKHFATVHAVIGLIVFFQTIAAGVTTKMLYPPMSTSPPAYPNQNLAKAHKANVGLLLLISTITLLSGFADLSSVSVCITNVVPSVVWMTLSLLSLTPIVLAAGSEALKWWLSKAPKSNTAIKSQISIVRDEKTDLKDTYGIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T943</accession>
    <name>A0A3D8T943_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_00797</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the 2nd section; belongs to the type-I 3-dehydroquinase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the N-terminal section; belongs to the shikimate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T943"/>
    <dbReference type="OrthoDB" id="4415835at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003866">
        <property type="term" value="F:3-phosphoshikimate 1-carboxyvinyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004764">
        <property type="term" value="F:shikimate 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009423">
        <property type="term" value="P:chorismate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00502">
        <property type="entry name" value="DHQase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01065">
        <property type="entry name" value="NAD_bind_Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000386">
        <property type="entry name" value="Quinate repressor protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10860">
        <property type="entry name" value="Leucine Dehydrogenase, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001381">
        <property type="entry name" value="DHquinase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041121">
        <property type="entry name" value="SDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031322">
        <property type="entry name" value="Shikimate/glucono_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013708">
        <property type="entry name" value="Shikimate_DH-bd_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006151">
        <property type="entry name" value="Shikm_DH/Glu-tRNA_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090">
        <property type="entry name" value="AROM/DEHYDROQUINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21090:SF17">
        <property type="entry name" value="QUINATE REPRESSOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01487">
        <property type="entry name" value="DHquinase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18317">
        <property type="entry name" value="SDH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01488">
        <property type="entry name" value="Shikimate_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08501">
        <property type="entry name" value="Shikimate_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01202">
        <property type="entry name" value="SKI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01100">
        <property type="entry name" value="SHIKIMTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Shikimate dehydrogenase substrate binding N-terminal" evidence="5">
        <location>
            <begin position="499"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Quinate/shikimate 5-dehydrogenase/glutamyl-tRNA reductase" evidence="4">
        <location>
            <begin position="637"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="domain" description="SDH C-terminal" evidence="6">
        <location>
            <begin position="779"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW95034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="818" mass="90381" checksum="150FCB8F8274330F" modified="2019-01-16" version="1">MATAISETSSAVRSPVASQNGGTAPINPGSSLDSNPRLLLTNSVAGPTRSRKLFAPDASIVLIGLRGSGKRSLGFIAATALGWRFITEDHYFETITGISRALYLKQHGNEAFRRMDVEVVGLMLERHRTRCVIECGLGSLATGAQTYLKEFCQTNPVIHVRRGMNRIQQLLRLDDAQARLMEQGDLAHRSCSNFEYYNLYDPNCETYREDGGLDGQLQYFPFKLKAAKEDFGSFVRSIAGPASPPNSLLQHISITALPVEQREHTHAVIVRFSEIVKSEVNIRDLESSEDAIEYKVDSMTENSLPLISKHIASIRRFVGVPIIFSVEGTIQDRNSVFSLFLLGLRLAVDFLVVNIDDEDSRISALVEAKGPTKIIGNYVELAPTAGAWTSRSRYAKYQAAEQLGCDMVRISQPAISSSDNDDVADFRNRVKALPGLHLPLIAYNSGRGGLESLLTNGVLTPVRRSLADSSSADDPAMTAREIMQELYRRSVLQPLHFYLFGDGISHSLAAYMHNGAYQTCGLNFDYEIRETSALSDLQAASRDPHFGGCSISHPFKVSVYHNLAQMSSRAKAIGAVNTLIPLRAAPDGQRDTLGDQLSHRGRVGPVIGWYGDNTDWIGMTTCIQRNLSPRNVIQPSKTTGLVLGAGGMARSAVYTLLQLRCRRVLIYNRTAAHAQQVADQFNVWLSEQQRHDQKVEILQSKQEEWPAAYHHPTMIISCVPAHSIDGRPSSDYELPLAWLSSSTGGVLLDMAYKPLNTPLLQQVRRLRAETGKAWIPVDGLEMVPEQGIAQFELMTGRKAPRGVMRAAVSRRYQDLERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9B6</accession>
    <name>A0A3D8T9B6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_00935</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9B6"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF43">
        <property type="entry name" value="QUINATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G16230)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="422"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="11"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW95172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="491" mass="54421" checksum="4BA3DE5E295D650B" modified="2019-01-16" version="1">MFRVRLYYVFTIIVIASGSIPKGYDEGGFSASITLKSFEQDFGLTESQWKGTASGLANRTANISSFGVLGAAFGSLIALALADRLGRLRCWRLFVLLWASGILMQVFSSGYLGLLLFARIWGGLGAGGLTVIAPLYLSELAPAKSRGMVVSIYMVILLSFLSLGFFVNYAASVTMPATSEQYRVVMAIPLVPVGIAFICSFFLSDTPRWLASKDQGEKALDILVRLRRSGRNNPSVIAEYDEILEQIHGSNQTLKNVPIMSILKEIATVSTYRERFLLGCTMQTVAQWSGGNGITYYIPKIFTYAGIVGNNTSLITSGAYGILKLVFTMMFTWFLIDRLGRRVLYMAQWKGSNNKSASDAAIASVFVYAVGWSIGLCTVQYLYGTEIYPTRIRGVCYATNMALHWFFQFAVVRVTANMFVSLGIWGAYVFWALVCAIGFVILGLWAPETKGVPMEKMDELFAGRWWMGWKAKRDLTDNVEMPTLKHGERET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q455</accession>
    <name>A0A3D8Q455_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_13088</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000025">
        <property type="protein sequence ID" value="RDW56623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q455"/>
    <dbReference type="OrthoDB" id="10557416at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW56623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="74" mass="7987" checksum="19DD6E5A3B18BCA3" modified="2019-01-16" version="1">MPFTSAFALAWAQRPPSTFRDGEIEDGAEGFRIIVPDNNIAATFGRGITSIEAAYRRGKLISVCAGEICARLVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q4V5</accession>
    <name>A0A3D8Q4V5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_12909</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000024">
        <property type="protein sequence ID" value="RDW56842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q4V5"/>
    <dbReference type="OrthoDB" id="189997at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF12">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="24"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW56842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="404" mass="45639" checksum="19C789D69B56847D" modified="2019-01-16" version="1">MRACAAAQLHLANTEPRPLNGHMHVESQMHRRIFWCAYHLDRLVSAAFDLPVSIPDTAIDAKIYANVDDKDLVQVAFATPPGTKLKGSSRFTEVSPALHIIQIRRIQSEILNYTLNCGFAAQFAAQSDWRNWILSELKAWKSQVHHYTEPGSKGYTSSRWFAIIYHCALLMLYRPTKDNVLGPAGDWSVQASTQACLAFRKSQMDRQVALPWLALLFQFQSGITLLYCFWATPENYRTPNFESSDIWDALRACSNTFAIMADHWPMAECLRDVFELLARDIPLVGRLNRDTPRISPQAVIQIQSSMPSVRSIVINRSVLRMIEEMITEDFPGADNEPPQVVLAEQSQVQYTNGSAINEISHPSSAPLPSEMPFFSDNWQNLYDGGVNLQEFGNETPLFPGLFDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q819</accession>
    <name>A0A3D8Q819_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_12611</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q819"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW57810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="223" mass="23994" checksum="49E65338E6D0881F" modified="2019-01-16" version="1">MSNNQTSRWRRVLSLPTGSQGLPQYSTQLKKTTSHGQIYLFDQFREKVPMNVKNHIIAVLSELVGTFLFMLLGLGGTSAAISLSRDNPVSPNKYLFIAASWGTSAAVNGWVFFRISGGLFNPAVTIAMIAIKAVSLFRGTLIILTQITACIAASGVLIRLVPPESVAMTELDKGTSVIQGLFIEMFLTAQVVFAIFMLATEKHKATFIAPLGIGVAVFAAVLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q8S2</accession>
    <name>A0A3D8Q8S2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_12635</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q8S2"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03469">
        <property type="entry name" value="Rieske_RO_Alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756:SF6">
        <property type="entry name" value="CLUSTER-BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="7">
        <location>
            <begin position="93"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW57834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="411" mass="46034" checksum="D59B118A53C2A24C" modified="2019-01-16" version="1">MFGLTAAAPPVFVCTFVALLVSLFLNIWLLINNFKFALNDLDAGPATAATNDGLIKRSELPQGWWTDSMLFQAERRAIFSKTWICVSHRSRFVKPGDYVSHEIAGFRFFLILGKDNTVRAFHNVCRHRAFPVTEKASGSSTILGCKYHGWCYNTQGQLTKAPHFDDVSGFDRSQNSLFEIHTKVNEYGFLQINLDGSKEAGESQLPDTKKIGKPAGINYGSQFLHSWELKGNFNWKLTVNDEYQNGNKTSKAASGAFRVFHTQDLTPADQLYFFPLTTVYTKSGSTLWYQLTYSPDSPQQTNVRCDVYSARKSDAAVFEGTIKDNLEAEIKAKIQKYEATYGTLTSSNCNPSDSSYDQARIADAVTAHLEQEKIEGREIKPATVQQCRSEAFTKAEKLCQALECTSDTLAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q996</accession>
    <name>A0A3D8Q996_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="13">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BP5796_12299</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 13">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 12 13">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 13">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="13"/>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q996"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00051">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF57">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 13" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 12 13" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="14">
        <location>
            <begin position="43"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="12">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00002224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDW58369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="467" mass="51548" checksum="3C98BAB67903F67F" modified="2019-01-16" version="1">MTLQPPTRQFTTSLRSPASIGKCYAKRVIPKLNLEIPLLIPTCTDKYSEGYPGARYYGGNEFIDQAERLCQQRALEAFNLDENEWGVNVQPHSGSPANLQAYSAVLNVHDRLMGLDLPHGGHLSHGYQTPTKKISAISKYFETLPYRLDESTGLIDYSKLEEIALVYRPKLIVAGASAYSRLIEYERFRETADKVGAYLLSDMAHISGLVAAGVLPSPFTHSDIVTTTTHKSLRGPRGAMIFYRKGIRHVVKGKEVPYDLEEKINFSVFPGHQGGPHNHTITALAVALEQAKSKEFKAYQNQVLRNAKALADRLGKGHGGLGYNLVSGGTDNHLILIDVRDCGIDGARLERVLDLVSLTSNKNTVPGDVSALKPGGLRIGSPAMTTRGMQEGDFAKIAEIIHRAVGITQRLDKEAKVASKESGRKNPQSVGAFYEYLRDNEDADVIKLREENEEWAGKFSLPWEKMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QB40</accession>
    <name>A0A3D8QB40_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_11986</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QB40"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38846:SF1">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="4"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="31"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="38"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW59062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="225" mass="25850" checksum="12C10DB9C9956CA1" modified="2019-01-16" version="1">MRTAKPSGFCFQYAESGACRFGSQCKYTHEESNKDQNNKALQSVPRNLTQSRKKPKGKGQEIKRPTDHIGDFFAQHPPFRHDSSAPIWSEFYRMCDDFDWGRHDPEMLEAKREFKSAMVLQFNGIYGKSERNMRSWKKLYRALNITPVPMDLNACRKIISKTHVNLVDLVDAPRTGASVMIFPSLTELQDYTIESGKFFPKSHAYAGGLLRLLLREILNARESLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QBJ9</accession>
    <name>A0A3D8QBJ9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12025</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QBJ9"/>
    <dbReference type="OrthoDB" id="3559448at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW59101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="547" mass="60600" checksum="22921B63AB86EB0D" modified="2019-01-16" version="1">MALNDPREQLLANLKCLYGSDVDVFTLCVVNTPRDQYQAIALRIDPLTKTWTKFLHGEPNCISSRDAIDTLLAQSERELAKLFLANGSIIPFQGDMVQTLTPQGRHRRDSVAADSMASEFSIVVTPASTLSDAVPDESVHEKHLIQVVTSKEPSVDEVAAEGAVVEVDELISVPEAPTPLCVKPEPAYRQTQLAEKYPTEVPTEEYPVEAGVKDCQIEREYPAVEVCDAGEEVPACYSGLDAPPLEDESSWGSFSAPKKDKKKIGKKGKKAKKVKTVTQEEEFPPPEPAPEPAEAFGWGFALKKKKKSQALIQDEEFPPEPAPEPEPEPEPEPEPELEPEPELEPEPEPELEPEPAPEPAEAFGWGFALKKKKKSQALIQDEEFPPEPAPELEPEPEPELEPEPAPEPAPEPAEDPSWAESQPKNEDSIWETLKPEVPLKPEPVAQSRQIVVLTIQFPNETSNKPLKVMAGIAENTYTAIIDTVNLYLDSKRLPNGLQGQRKVQITYGIGRDGAVDLSNLAETMWPEYLDYFRQYTKIPELTVDVMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QBV1</accession>
    <name>A0A3D8QBV1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_12173</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="662"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2125"/>
            <end position="2204"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="7">
        <location>
            <begin position="662"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="792"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="7">
        <location>
            <begin position="811"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="2212"/>
            <end position="2276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="804"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="2222"/>
            <end position="2243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="2252"/>
            <end position="2267"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="7">
        <location>
            <position position="693"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="7">
        <location>
            <position position="872"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW59249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="2276" mass="251307" checksum="A249D4689162D81E" modified="2019-01-16" version="1">MPSSTAQTQLIRQTYARAGLDIEKDRCQYFEAHGTGTKAGDPQEAAAIYRAFFGERPNETTDHDSLYVGSIKTVIGHTEGTAGIAGLLRASLALKHGYIPPNLLFDELNPDIEPYYGRLQILKTATLWPELPPGVPRRASVNSFGFGGANAHAIIESYEPTAPSKTETRSSTAAIPFMFSANSEKTLTNQLQKFLSYLDDLDEEATNMRDLAWTLSRRSAFSLRSSYSALTLETLRNKLRTAIDAKNKDGENNGVRPSHKKHTILGIFTGQGAQWPQMGYRLIESSPMAAKVIESLDESLQSLPKHERPDWSLREELCKASDTSHVMEGTYSQPLCTAIQILLVDLLKEAGVTFDVVVGHSSGEIGAAYAAGFLSAQDAIRIAYYRGLFVKVASGPSGTAGSMLAVGTSMEDAQELCELATMKKYGKFNVAASNSSASVTLSGDAKAIDRAKFIFEDEHKFVRGLQVDTAYHSHHMQPCAEPYMNAMARVKIQVQESDMSCQWYSSVLGGDLVTSDMKEQLAGSYWRDNLLQPVLFSQALEAALEKTGAPALALEVGPHPALKGPAGLIIEEKLGSAVPYSGVLARKVDDVEAFSGAIGTVWATVGSAPLDLGRLDRAFASQSLDKPKFLRSSPGYTWDHTQSFWAESRLSKSMRQRQHGHHELLGVRLDGRENELRWRNFLKPSEIPWVRGHSIQGQTIFPGAGFAAMAIEATKAFGADAGEEMELIELEDLTIYRALGFLDENAGAEVIVALCNIERSYGLILCDFVCEACPTRDAPPATVSTARIRLRLGPGSPQTLPPREPTEDGDKETEVDTDIFYSSLAKLGYNYADMFKGITSLSRKRLAASGVIHTVIDSGYKPDLIVHPAPLDVAFQGLFCAIGAPGDGQLWTLMVPTVIRSIKVNPFTCNQTGCLGMDLSFDAGVQVERSSHHISGDIYLYDTDGTAMLQIEGLQVTPVTQITAKDDAQKFSETSWAPEKPDAAKEYTEFWNVETEKYEKSYFIERSCFFYMKRLHDAIPLEERDDLEWHPKKYLSWVASVVEAASAGTHPTIQKEWLDDTLETMEGPMKKFAEQYEDFHYLTILGDNLIPFIRGEVSLLELFRGSDVLDHVYKHTYSVPEYNSYLGSLVGQLAHKHKQIEILEIGAGTGSATEAIMSRVGHHYGSYTYTDISASFFPDAQDLFKDQDSKFMYKTLDIEQEPTEQGFSERRYDLIVASNVLHATKSIEKTLKNVRKLLKPGGYLVLLEITDTDPVRQSFFFGSLPGWWLGEEDGRVHHPLLPQSGWDAALKKSGFSGIETTTPETGMFMVPLSVMLSQAVDSQMQLIREPLHMEHSNLDAVKLPKLLVLAGQDIVTAQLQDEILSALRPFSTEVEIVSRMEDLEERNFSPKQLVLSLMELDTNVFNPFTPERWNAIQLLTEKSANILWLTRGGAGENPFSNMMVGVSRCLVPEKPDMRLQLVDFATNEPVDATYIASTLMRMHISAGWNGWVEPYITTWVLEREIRVVDGQVMIPRMVPCTAIDSRYNSSRRTIREEITLEDAVVALVNKMGTYELREARKPSWAVPPREDFVQVETLRSTLAALEIPSVGSLYLLVGKVVGTAQTVIALSETLQSRVAIPEDLVLPVDLPEDQALQLLITAANYLLGDYLISHTAKGTALMIHEPTPLLAAALNELARDRHVVLRLTTSSSGCPDWQYIHPRAHHRTITALLPPKLSTFTYFSNADESAQSGAHIEAHLPSHVRRLSPKEFFASNDSAYLKPQANPEDALKLLQQARAFFELHSGLDAAERVQEVGLDEIPGYRPDRMHFILEVLDFSSQSSAWGALCPAEDMVQFRTDRTYWLAGLTGELGLSLTRWMIERSARYIVLTSRNPKIDEKWLEAMQANGVTVKVFPMDITNAESVSKTHTIITETLPPIAGVCNGAMVLNDGLVAKQSYEDFNATLEPKVKGTTYLDALFQKPDLDFFIIFSSLAYTTGNIGQASYAAANGFMVSVAEGRRRRGLAGSVMNMAGIYGIGYITRREANLMDRLEKLGYSNISEWDYVQFFAEAVLAGKPDDDAISKVWEISSAIRPVDADAENQPPWLQAPRFSWYKKARGNAAERDDSGTISVRENLKEQTTMQGVSKALLAGFVANLYKLLGMRPEDGAISPSTPLIELGIDSLVAVDMRFWFTRELDLDLPVLKLLGGATVEEMVEDAVARLSPALIPNVKDAPKPAVEEGAEPAPNDESEEDSSAQDENDDGKSHGTSESDAPSAGTSIGTTPPESIKDVPMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QE36</accession>
    <name>A0A3D8QE36_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_11718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QE36"/>
    <dbReference type="OrthoDB" id="3260716at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW60112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="145" mass="14782" checksum="D9A2975FAA0C85F4" modified="2019-01-16" version="1">MSSNPDSVSNQGEFHSRIAPSEPLTTSGHKPGLKVGSDAAPEFHAQTLPTGTAPADRTFKPDTTSEVPGQAMNPNISKETWTSASDTIGGATSADVHTGYGLPEGQASTELHGSGATKGKKEELGLAGRPGGPDKFEGTLDGGRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QEC3</accession>
    <name>A0A3D8QEC3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_11594</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW59988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QEC3"/>
    <dbReference type="OrthoDB" id="4194555at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="31"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW59988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="872" mass="96923" checksum="CCC74EBCB24016C0" modified="2019-01-16" version="1">MSDSSPTKRRKTRGLFSMESRNTTSNLTWPTSDAKRLPVEIFVIIASHLSRQSIQSMRLVCKEFEEKISEYLFRVVVVPFKPEIYGITPEPNHGGMLHENDILKGSIMLQDKGMRVFQGFGQHIKRFALSFEFDEDKLARPPVKSDQEAITSFWGIYRWPFKSYNRYSQLEGLEQTADETRTMAKALRFITNASELGLSVDGGLGWLAGPDINMVVLERDGSVPVFGESRFPLDDASNVERIRKAKARAARFSGTSFEDTTTSSEWSALERMLTEAGYGGADLERSVQTLLDSERLGSSTASSSSTSTQTTYPAFRRMQKGRFSNGRPARSVSTSIAAQNINAATMSLLLPNTTPNSSTQVDSVHDIPGDADAESPGQEVSNQNLVAFPVSISDDDDDDDNAFQIITDNSHPAIKTEVCPLKPNDLTNAQKEMLLEMEWAQRAFMQSYAIAIIDNPVTFQNITTLTIARLPNRHLPILRREDFWDSLPRVNKLSIAVIPDWREVVKLPTSWVQDNRVEPSQSITGVYQLLQDQISRRKNIEAVHFEWLCGGEESPGIFSRNQHVLAAPLTSKAPEMVNRRQQTQILTLPYVKHLSLKNCWISPHVILQFVSSLKHGHLEGLLLDSVSLCAPVSNNAQPNILTGHANNNHAAQNAHLHVQAVANIGVANGFPMLANLHHLQMHHAQQLHHPGQNVPPAPVVIAPPAAPQPQSNQKWFDPPRVGSWPHVIDNLTPGERLAHFRHARDLGPEPPASKPTHLKRLEFRSCGYVRLALDMDQSMFDPPDAPTANTTSFLKRMNDMEGVMMKPNDPYLGVIASHIQQVEETALENGWYMQIGWSGDQWATLTTEAAADGVRSPGQGRFSGVIDVGSAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QEG4</accession>
    <name>A0A3D8QEG4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Symplekin/Pta1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_11821</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QEG4"/>
    <dbReference type="OrthoDB" id="331600at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021850">
        <property type="entry name" value="Symplekin/Pta1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032460">
        <property type="entry name" value="Symplekin/Pta1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245:SF20">
        <property type="entry name" value="SYMPLEKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245">
        <property type="entry name" value="SYMPLEKIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11935">
        <property type="entry name" value="SYMPK_PTA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Symplekin/Pta1 N-terminal" evidence="4">
        <location>
            <begin position="92"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW60215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="731" mass="80992" checksum="5FA81CF17D2B052B" modified="2019-01-16" version="1">MAAAPALTPAQQIKQLNDARKLVLGDPTFYPQIVQGVVPISGKGSRLEMRRWGADFLAETFAMPTIPPLEKESLSLFVLESIKDMLEDPTEDPGVIKSLVQTAASIYPLVFRWIINNAYDAPSWERMVAIKSRILRMWDTASPGVRICCIKFAQRVVLVQTAGPAADPKRGDPLEISLAMVPPSHPLIPARNLDAEAQALLDRMLSVFQENSSDAILVDATLNTLPVLIRARPQLANKILTVILNFNPLKLANSPMTPKLRVMVKSMEKTTRSLLINVNKRDPQNPLAQRIQQHIERLLRSRTDIFDESTRKRGPPEPIDGLDAAKRQKLGAQLPPPVRIHIPPLAPGPHTIGELFTISADDGLKAFDVAQLAPDLVAKIDVTILQRLDKELLSQAINGIRQRLESMAAVKPEQLNPATAPLSVEEDEDDYEPDFSVAEDTEQILNKLDAEPTGSEEPEAMAGVPDMALGTFVLPQPPPMSLNEIMQAGRASISRLFATMQSLDEPGKKSKSGFNRLAASSNDRDAWITVITRIATRSTYGLEDASVKKEEPDHATISDIVRETLYLYVLEDFRKRIDPAVSWLCEEWYNDQVSIRALGAEKTIQHYEKWALKVLDGIVPYLDAKDKVLTRFLSEIPSLNPEMLSRIKNLCRDPAMISLSITSLVYVIMFKEPAREIALDALEAIHESYEDAKPMAAKFLTKHRPGWDARLKGLDNGEAKVEGASAVATVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QEM5</accession>
    <name>A0A3D8QEM5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 76 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_11704</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QEM5"/>
    <dbReference type="OrthoDB" id="9984024at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053169">
        <property type="entry name" value="MUG_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47791:SF3">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 191 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017624944" evidence="1">
        <location>
            <begin position="29"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW60098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="378" mass="41785" checksum="ACC65048E0F137EF" modified="2019-01-16" version="1">MPTAQHFRTLHRMLLVVVLILLSYQVQASPNTTHPEDASSSAEKAADALESLMTWYNSTTGRWGNDSVVPWWLSGNALQATLDYMDKTGSREYMWDAKNTIAIQRAPLTWWPEGEGDFRADSTDDTGWWALANVKMYSLTGDEQYLTIAKEDEAYMYSYRDNGTCGGGILWDIPTKTYNNAISNELYLLLAISIHNSIPGDTYYLGQATREWNFFKNSGMINNASLVNDGLTETNNSCINNNGITWTYNQGVILGGLTELYKATGEYGFILTARSIADAVIASPLLTQNGILTETCESDGTCDSNGPAYKGIFVRYLSQLNGVLPNRPYSSFLSAQVVSMYNLDRNGTDFYGLHWAGPLDDVDIATQTSAVSLLTAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QEV1</accession>
    <name>A0A3D8QEV1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-histidine N-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.85</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_11784</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the methyltransferase superfamily. METTL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.85" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QEV1"/>
    <dbReference type="OrthoDB" id="1723750at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018064">
        <property type="term" value="F:protein-L-histidine N-tele-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF39">
        <property type="entry name" value="HISTIDINE PROTEIN METHYLTRANSFERASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW60178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="360" mass="39181" checksum="40146466F92366D8" modified="2019-01-16" version="1">MSFSFSFSGDDIEDVPTTDAEPPILNHAAETGQLRKRAPSTAFPISGQPLLTPQAHSLQSLLESLPSKIQYSTLNVRLDDGTEVRFPRRELWDVRVQLMAEDDEEGLGNLGKDDVKTGVYEGGFKSWESSVDLVRVLAARRGELLAGDARRILELGCGTALPTLAVFQWALQSYAEHSSNPLHLGFADYNPTVLRLVTLPNILLSWAQTTHQEGEGPWEPTSELEITESLLAAFTANLQQCNISLTFYSGAWSPSFVSLIQSEVSQAPASLTIIGAETIYSPAALKAFAETLIAVLMLNKDTSKSMALVGAKMVYFGVGGSVEDFCDMVVLHGASVERVRMEEDGVRRAVVKVCMAEIQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QF57</accession>
    <name>A0A3D8QF57_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S8/S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_11894</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QF57"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04077">
        <property type="entry name" value="Peptidases_S8_PCSK9_ProteinaseK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000007">
        <property type="entry name" value="Subtilisin-like serine protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034193">
        <property type="entry name" value="PCSK9_ProteinaseK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017701352" description="Peptidase S8/S53 domain-containing protein" evidence="7">
        <location>
            <begin position="22"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="167"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="176"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW60288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="425" mass="43267" checksum="9E365A20BF582315" modified="2019-01-16" version="1">MFLSIRVFLSFFAFFIAVVAAAPRTKHGAEVNGIGVPVSNPDAANIIANRYIVVYNSNASDTAVAKHQATIMTAMRKRSAALRKRDGTSFSAKMNTFSMTGWRAMALDAEDAMILEIANSKMVNYVEADTYVKTQALVSQANAPTGLKRLSHTATGGSEYIFDDTAGAGITVYIVDTGVRTTHSEFEGRATFAANMVNTVNTDENGHGSHVAGTIGGATFGVAKSVKLVAVKVLDAAGAGTNSGVIAGINFVASNATAMRLSGKSVMNMSLGGSKSQALNSAIAGVTRAGVVAVVAAGNDNVDAVNSSPASAPSAITVGAIDARTDTRATFSNFGASLDVFAPGVNIQSVGITNDTATNVLSGTSMASPHVAGLAAYLMALNTSLTTPAAVTNRIISLANKTGAAVLKAGTGSPTLIANNGDGQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QFX1</accession>
    <name>A0A3D8QFX1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_11920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QFX1"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630:SF7">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31630">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW60314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="336" mass="37942" checksum="3C8AD38F20F8C98F" modified="2019-01-16" version="1">MTTTTAVTSPVQRLVSEPAPDRLAMSGSSGPLSDWHRDLIRDGFAVVKGAVPKERADKYANDMYTWLEDFNLGFNRNDASTIHKDNLPVINEKGMCLHYAVTHEDFVWQVRSEPGVVGAFETVYNDKDIIVSFDAVGFGFPNRTDLPKNVPWPHQDQDPEKPGFRCLQGLVNLLPNGPDDGGLIVCKGAYHLSEQFHREMAWEDRIPQWTNEWYGFTENGMKWLADHGCEWVKVCAEPGDLLLWDSRVPHYNLSSTTSQPRFCVYTCYMPVADVTQDDLVHRVGTTHWPNARHVGGNVAKRDGEIDSYNRICPRKDAVLSERAFQLTGIPYIKAST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QHH1</accession>
    <name>A0A3D8QHH1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nad dependent epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_11185</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QHH1"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF579">
        <property type="entry name" value="3-BETA HYDROXYSTEROID DEHYDROGENASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G02250)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="10"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW61293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="346" mass="37205" checksum="F3FCAFACB3C4D102" modified="2019-01-16" version="1">MPSITAPATVLVTGANGFIAAHCVAHLLQANFKVVGTVRSSAKADAVLQSHFNHPNLRLEIVPDVTTESCFNTAVEGCDAILHLAAPFGYAYKDFEEELLLPSINGTLAVCEAASQEESVQRVVLTSSFASVYDARKGLNPEKTYTEEDWCPLTYEDGKNAAITPVAYRASKVLAEKTAWNFMEEKHPKWDLVTLCPGMVFGALLPGAIESIAQLNTSNAIVWSLIDAKSVPDTKAPIWTSATALAAAHTSALVTAAASGERFLVTNGTYDFQELADIIHASSDTPVNIKIRVPKGESGRRLAESHYKVDNSKGLKALALEEPTLENTVIPLIKQLAELETITAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QHW7</accession>
    <name>A0A3D8QHW7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_11335</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QHW7"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF2">
        <property type="entry name" value="AMIDASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="6">
        <location>
            <begin position="76"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="3">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="3">
        <location>
            <position position="231"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="228"/>
            <end position="231"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW61443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="548" mass="60380" checksum="92BDC26D659BDFC3" modified="2019-01-16" version="1">MAPWEDIAAEKQEQRADKIPERWRIPSDLMPSEEVLDVQDWPKTSGFFTAEEIAITELTASEVVAKIAKGDLKAADVVDAVCKRASVAQQLINCVTEIFFEGAMARAKELDAYFEKEGKTIGPLHGLPISFKDQFNLKGLDTSVGYISWANKPASEDSTLVTLLCNAGAIPYIKTNIPATLMMGESVNNVFGRTKNPRNRNLTTGGSSGGESALVTFRGSYMGVGTDIGGSIRHPCSFTGLYGLRPSHGRVSYQRVANTYLGQEAVRSCAGPMCRSPSDIRLFMSSLAAQKPWLYDPQAIPITWREDEEILPKKLCFGFGMGDGVVTPTPPLRRAMEMTKKALLAAGHEVIDYIPKEHIEAVEIITKMWSADGGEEFQRDTDASGEPLHPQLEAWLGHSAKAKPSSVFETWQNQHRRTTLQTAWLERWQATQAITGTGRPIDGLIMPSTPFPAIRHDGGYPHHWGSLSPLLDLTTGAFPVTKVDLEKDIVPVDWKPISDLDQKITDYYGKPENHENALVGLVVIARRLEEEKVTAMLDTIKDCLAAQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QJ32</accession>
    <name>A0A3D8QJ32_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_11336</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QJ32"/>
    <dbReference type="OrthoDB" id="6132759at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015489">
        <property type="term" value="F:putrescine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015204">
        <property type="term" value="F:urea transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11476">
        <property type="entry name" value="SLC5sbd_DUR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1730.10">
        <property type="entry name" value="Sodium/glucose cotransporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031155">
        <property type="entry name" value="DUR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038377">
        <property type="entry name" value="Na/Glc_symporter_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001734">
        <property type="entry name" value="Na/solute_symporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46154:SF4">
        <property type="entry name" value="UREA ACTIVE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00474">
        <property type="entry name" value="SSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50283">
        <property type="entry name" value="NA_SOLUT_SYMP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="258"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="496"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="567"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="599"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW61444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="669" mass="71624" checksum="D3EBE6ABA79F41CB" modified="2019-01-16" version="1">MVTVAGKPPLSQGVAYGVVLGFGIVFALVMNGITWVGRKYLNESSDTQMLMTAKKSVKTGLVASAVVSSWCYAATILNSVRLTYVYGFAGLWWFVSGATCQIVCYAIMAIELKRRAPRANTILEAIRIRFGTSSHLVFFAYGVSVQILITAALLLGGSAAMTATTGASTVAMNYLIPFGVVIYTYLGGLKSTFLSDYIHTVIIFVILLITMFKVMASSSVPILGTPGKLWDLLGPASLESPATGAKDGSYLTLDSGEGLLLAGVILVSGFGSVFVDPSYGQKAIAGEASAVVKGYFYGAFAWFSIPLGLCATMSFVAVVLQNTEYWPTAGGVTAYQINNALILPLAAQATMGVGGVVAIILMVFMAVTSSFSAEIVAHASIVTYDIYQPYINPKASDSQLKLISHMSLAGFALFSASFATALNASGVSMGWILEFVGVFTGSAVIPITLAISSSHVSPCFITWAPPIGTICAVATWLGVTKGMYGAVNVNTTFENWPMFAGCLVGLMLPVVAWCCMRPFSKTPYDWDNLFLMIPLEPRPGDVSFSHDDDDSLGLDWDPKELARASKMAKIVSGVLCLIFLVLIPFPMYGTGYIMSRKFFTGWTVVVFIWSWCAALLIWCMPVWQSREPLLRVFKGIIGKSDNVKREETAEAVVGVEIIGDGKEVSQKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QJ66</accession>
    <name>A0A3D8QJ66_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative fructosyl amino acid oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_11366</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MSOX/MTOX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QJ66"/>
    <dbReference type="OrthoDB" id="2219495at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051698">
        <property type="term" value="F:saccharopine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008115">
        <property type="term" value="F:sarcosine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045170">
        <property type="entry name" value="MTOX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961:SF26">
        <property type="entry name" value="L-SACCHAROPINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10961">
        <property type="entry name" value="PEROXISOMAL SARCOSINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="6">
        <location>
            <begin position="14"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW61474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="437" mass="47883" checksum="BFB5A5D4F3866B61" modified="2019-01-16" version="1">MSSSSTSSRSSKSILIIGGGTFGTSTAYHLSQRGYTSVRVLDRWPIPSIEAAGNDLNKVVRADYAEPLYSRLGSEAMARWKDENGIFKKYFNPTGWLLGAANVSLPFIDKSIENSKALGVNLEYMPHDEIRKRWPRVTGKMSGWKVLWNSAAGWVDARGALTAMAQAAARNGVEYISGDAGYVTTLLFDNDKNCIGVQTADGKKYMADEIIMAAGASAGSLLDFHGQLVAKGHTVGHLQLTAAEAEYYKGLPLVDQLEQGMMFPPTSDGIVKFAAVEFFTNKGKHSTIPGISLPRYRSDHPQDTIPAAYESKIRNFIKELVPELANRPWVETRICWDADTPDLHFLIAPHPIHRGLKLAVGGSAHGFKFLPVIGKYIVDMMEGTLEARMGEAWRWRPGVTSAKAGPEPHPFKSLDLENLEGWNLEGNAGKSGRQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLE0</accession>
    <name>A0A3D8QLE0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trafficking protein particle complex subunit BET3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_10914</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Golgi apparatus</location>
            <location evidence="1 8">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLE0"/>
    <dbReference type="OrthoDB" id="10262857at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14942">
        <property type="entry name" value="TRAPPC3_bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000001">
        <property type="entry name" value="Trafficking protein particle complex subunit BET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016721">
        <property type="entry name" value="Bet3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13048">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018293">
        <property type="entry name" value="TRAPP_I_complex_Bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR018293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW62612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="192" mass="22107" checksum="C505C5CD83D050ED" modified="2019-01-16" version="1">MAANKAARMGEEVWKTRVDKVNAELVTLTYGTIVAQLCKDYENDYVEVNKQLDKMGYNIGLRLIEDYLAKSNTMRRCSNFRETAEMIAKVGFKIFLNITPTVTSWTSDSKQFSLIFEENPLADFVELPDDGRSQDELWYSNIFCGVLRGALEMVQMQVEAHFISDVLRGNDTTEMRITLIRYIDDEMPQDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLW7</accession>
    <name>A0A3D8QLW7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">GOLD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_11094</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLW7"/>
    <dbReference type="OrthoDB" id="759142at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017715786" description="GOLD domain-containing protein" evidence="9">
        <location>
            <begin position="24"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="39"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW62792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="219" mass="24721" checksum="CB6DD54E3DF624C0" modified="2019-01-16" version="1">MAYPRSVLQLLCSLLVFLACAEALKFDIQAYTKGDKKGERCIRNFVGKDTLVVVTATVGGHKGDGMKVDMHIKDAVGNEYGRPKDVVGEQRMAFTSHADASFDVCFTNEFTGSKSVKDANRHIELDIDIGADAKDWSAVQATEKLKPVETELRRIEEMVAEIVSEMDYLRQREQKLRDTNESTNNRVKWFAFGTMGMLVSLGAWQIVYLRAYFRSKHLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQA0</accession>
    <name>A0A3D8QQA0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_10474</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW63972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQA0"/>
    <dbReference type="OrthoDB" id="43906at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048250">
        <property type="term" value="P:iron import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000029">
        <property type="entry name" value="Solute carrier family 25 member 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758:SF4">
        <property type="entry name" value="MITOFERRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758">
        <property type="entry name" value="MITOFERRIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="21"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="118"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="211"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW63972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="311" mass="33579" checksum="C1949AAE1B2197C5" modified="2019-01-16" version="1">MAQPNAEPVEEYEYEGLPPNFSLLQNMAAGAFAGIAEHTVMYPIDAIKTRMQILNPTPSAVYNGIVQGGYRIATGEGILSLWRGMTSVIVGAGPAHAVYFATYEAVKHLMGGNQAGVHHPLAAATSGACATIASDALMNPFDVIKQRMQIHNSHKMYRSMTDCAKYVYRSEGLSAFYVSYPTTLSMTVPFTALQFLAYESISTAMNPSKVYDPLTHCSAGAVAGGFAAALTTPMDVVKTMLQTRGSALDPELRNVNGFMAGARLLHRREGFGGFFKGVRPRVVTTMPSTAICWSAYEACKAYFINQNDTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQI7</accession>
    <name>A0A3D8QQI7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 19">Autophagy-related protein 9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BP5796_10473</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(in) = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)(out)</text>
            <dbReference type="Rhea" id="RHEA:67920"/>
            <dbReference type="ChEBI" id="CHEBI:58088"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out)</text>
            <dbReference type="Rhea" id="RHEA:38663"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out)</text>
            <dbReference type="Rhea" id="RHEA:38571"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out)</text>
            <dbReference type="Rhea" id="RHEA:38895"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Golgi apparatus membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3 19">Preautophagosomal structure membrane</location>
            <topology evidence="3 19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 19">Belongs to the ATG9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW63971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQI7"/>
    <dbReference type="OrthoDB" id="2020634at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030659">
        <property type="term" value="C:cytoplasmic vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006869">
        <property type="term" value="P:lipid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061709">
        <property type="term" value="P:reticulophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007241">
        <property type="entry name" value="Autophagy-rel_prot_9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038">
        <property type="entry name" value="APG9 AUTOPHAGY 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13038:SF10">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04109">
        <property type="entry name" value="ATG9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 19" id="KW-0072">Autophagy</keyword>
    <keyword evidence="14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="11" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 19" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="13 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 19" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="215"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="278"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="446"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="532"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="635"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="99"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="773"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="156"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="20">
        <location>
            <begin position="829"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="917"/>
            <end position="926"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00006185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00024479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00024631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU364027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RDW63971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="926" mass="104602" checksum="6B9CF5F8D36BB694" modified="2019-01-16" version="1">MMTSNLISRLIPTNPNTRSIYEDLRAHEDASDSDIEERAGMALDEENLRFQGTDLDAADIFNGEDSRLTTVSTDFMTRKHAAPDAGKSRANMAASKWLPQSPRLLEEDGDDDVPASLLIEDNRGPSSQRSPHGRAQKHSSRPYAVPGPSTRETRAQWEAAQAQQQLHPDDIPNPNTPRPVKQKAGVLTGSPRDKAMWTWLNVTNLDDFMRQVYDYFLGAGIYCILLEGVLGLLKTIFVAFFTTFLTQCIDYKKIPTSREMSEIVVPQCTKKISGMPNVAIWLFSLFVLGKTYQILADIPRLKRLHDFYLHLLDIPDGDMQTISWQDVVARIMALRDANPLTATTPVAPGIRKFIGSQNKERLDAHDIANRLMRKENYLIALFNKDILDLTLPVPFLQGRQLYSRTLEWTLDFCITDLIFNKTGQVNQMVLKESHRRQLSDALRGRFLFAGFMNVLLGPVVVIYLMITYFFKYFNEYHKNPAALGSRQYTPLAEWKFREFNELYHLFHERINMSYPFASRYLDQFPKVKMVQVANFVAFVAGAIVSIITIATLWDPELFLSFELTPGKTALFYGGIFGTLWVVAHGVVPDENLVFDPEYALRNVIEYTHYEPASWRGRLHSDEVKRDFASLYQMKIVIFLEEILGFIVTPFLLWFSLPDCSDQIIDFFREFTIHVDGVGYVCSFAVFDFKKGPGKTGPGSGANTDMREDYYSTKHGKMAASYYGFLDNYLLNPKTGVPGHLPPGMRRPQFHPPPAFPGLMSPTLAADMQASRMGRSERLPRNRGHTAVGLPTSARTPRFQPTGAHAASPMTSILLDPHHQPSNSGFGGRSVRRNSRSRYQIRKDILEEPLEDDEDRPGRTRQESGQTGAPYESVVGLDQSRWELSPVRNMPKEVTEEEDDGGAPGGGVLGLLDQLVKTQRDGRSGIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QRC3</accession>
    <name>A0A3D8QRC3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_10720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QRC3"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="93"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="175"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW64218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1047" mass="117761" checksum="02CB15E54BACE880" modified="2019-01-16" version="1">MPSSLPVPSKGALRTLRNLALGTSCTVSFTAGLLTEDRRRRIHAAREVHENAKRIKSSRSYHSAGAAPIVDRFEDQIRINQEDGPLLLGRKQTGRPERLASEKCALKPAIGDIQSDPSRREQCLDSRPPAERSNDPVPTAAPQVKLQWQVQTRRVNSKDPRGYNPDWHPIQQRTTLASVSDPFHGTSATARRQEPTKENDKQFSIRGKGRQIRLASDVKNLLNGATDVADVDAAASRFLDAFDDGFEIGYSGVSSSLMNAAIDLSTACLCHSRLQAVEKILLLMLEFGPIDEAFYSLLSPLKVIENLVQGPLNDHQWIQVEPDNIQKAAKIFLAEFKERPQKLSELGMALGVELCAQTYRIGMTKTTVKLYGRLQAVRGDSNRHLQALKYNILAEHHNGKHKYVVDHFSRWFKHTMPNQSDFASVGSAALDSALVQSRFDRAEKVVAVASEIAIANRLVVSTTWFLRLLGGFWRSSKDIESTRALFDRLEASLKLVPRPVAAYSAIIQFCVEAGDEPTARAYQARLESIYGRQETDIRTCGHFALAKAMRGEWQGVEDDFEFMSKSLTEATIPTYSKVFVPILMEYIRTHSLDEIEHFLQLFTQQYKVPLHVFMSNAMVDAYARARELGSMLRWLQYAAATTSTMDAVTFNIMLDNCHKTWGFKFDELYHLFDSVQSMQQRNGESLVDSTTVAILRNVAMTEYKREKDSGALRRALKLLKKIPVSATTEYSVDSHEIGNSIRLALSKGDSTTALQIYGKALKHHVFLHASVIGTATQASLQIHGRDFTPTAKLLAEARENRYDITIALGSVFVYEMTQRTKQPGLEPVDVTSIVRSMGSTLSDQQHILPAAATHAANILVSRGLHQEALDLWTTVTRQQSSSRSFIDIVTLTVLVQAYIGLRNSSGIDWVIKMMKENDLIPDKIFKMYLLNARQKTLRYMERNLLYLDQHEMIQLQQFHKTLDRAFKMTAEIKQDATKLRNNVRLETIRIMQEAVRAQKGDPELDFEEAVASDVEEVQNFRNAHNALRLWEDEVQSAWPQAAVAEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUU9</accession>
    <name>A0A3D8QUU9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Endosomal spry domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_10249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUU9"/>
    <dbReference type="OrthoDB" id="5393404at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW65557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="44165" checksum="A6457BC6A095508E" modified="2019-01-16" version="1">MAPVPESSITSIIKRSAHTLFTRSGAILPRSTVDPSAGVTDPSSIPNKAVFILFGILGVGFVCTGIWFFFWAKNGGFYFHDNDWDDYKSTVLRRKGPNGTTLSGATESTDLGGGSVVHGQKKWRRKNKKSEKSRYKDDFGEDEGSSMTGSSAMSEVKWAQNEKNERRSKRGLRGGHMDDEESVIDAVRAYRHEKPARVGGINKQPDGSSWDGSNTDAQTDLLSNRETTPTSTPTKPKKRERKDSFTTAKGGIRKVMPSTTANTSTSFWSRSNPSQEPTPSEDDRIKSEARKLQEKGRAAQRRDFSFQKGDDSSTVADEAEERRTRREERRARRRAEREALVPGSYAESSVGGSEISETGTKTYHHVIPGLSSTAGSDYAGDRRKQRKGGYRRGGTGSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYL2</accession>
    <name>A0A3D8QYL2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Isocitrate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_09393</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>(2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate</text>
            <dbReference type="Rhea" id="RHEA:16809"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:57429"/>
            <dbReference type="EC" id="4.1.3.30"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Can also use Mn(2+) ion.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYL2"/>
    <dbReference type="OrthoDB" id="4078635at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004451">
        <property type="term" value="F:isocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046421">
        <property type="term" value="F:methylisocitrate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006254">
        <property type="entry name" value="Isocitrate_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01346">
        <property type="entry name" value="isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631:SF3">
        <property type="entry name" value="BIFUNCTIONAL GLYOXYLATE CYCLE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21631">
        <property type="entry name" value="ISOCITRATE LYASE/MALATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00463">
        <property type="entry name" value="ICL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001362">
        <property type="entry name" value="Isocit_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5 7" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="6">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR001362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001362-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW66644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="518" mass="58547" checksum="1A932EC5E8ECF0DA" modified="2019-01-16" version="1">MPRVARSVDEEEEAFNACIRRIEEWWRTPKQAHLKRPYTAARVAGLRSNLEQKYASSDMAEKLWKQMHEHDAKGTHEMTFGTTDPIIASQIAKYSQTVYVSGSLCNSSETYEPGADHADYPWDTVPKVVEKLFRGQQWQDQRQRHYRMLHSKEERAKMDEWDYLTPIVADGDMGFGGLTSTVKLTKLFVESGVAMFHLDDLAIGCKKFTTGEGRTVIPLCEYEDRLIAARLQIDIMGAETLLCGRCDVDDSEYITNVIDPRDHEYIQGATVPIESLEKVLKAASAAGKPVLSARKQWISDSGLSTFDEAVQKVASESEFAAYKAKLGDQTVPIEQRRMIAEATVSKPVFFDWDLARIRGGQYFYKTCVKAMIERAVAVAPLTDVTWGRMDAPKWEKIQKFHQGMRSIIPDRLFLFGYTGQYDYPKAGFTEEMVKNMGVEMAKMGVVWQVQPVWAAQGMNMVVDEFAKMWAEEGIAGYVEKVQKPALAMSPNPDGFGKTSYRGAHFADGLYDAIVSRDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R2U3</accession>
    <name>A0A3D8R2U3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_08935</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R2U3"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF4">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="407"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="449"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="476"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="512"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="543"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="97"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW68278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="584" mass="63552" checksum="3133CF03081D9545" modified="2019-01-16" version="1">MPDYEKQHPNVATTLTTAPAPTKIETNVSTKGNVDAIDRVFVAAPGTEIMMDEDGHGSTENRLRTLQHAKIGDGHILLVPQPSLTDPNDPLKWSTGKKWMVLMNGVYYAFNGAITGPMMAGGMLQLVAFFDVSLAAMSHANGATLICQGLGNIFWMPLAVKFGRRPVYLTSNFLMGIACIWLAICAEKTYTPFIIGRAFLGLWQAPIEAIVPSTVTDTFFLHERGEKISIYGLGVLGGNEIGPLISAYIIQSLSVRWAFFVIAISVFINQITLVFAMPETKYTGTRPQILPPGLAQEEKEKLASELIKGGEVADLASNPLGATASTDPNQPIAKITYFQNLKPWSGSDPNVNLVKTFLRPFILVTYPTILWSSVIYGLALGWNVILGVSVAQLFAPPPYNFQSGAQGLIFLSPLIGSLVGTYLCGPLADRIATYYTKRNHGIREPEMRLPACAIAILLTFFGTLVAGLSYNAKTHWSGPIIGFGILSAGAQMGATLAMAYSLDCHKQLSGELMVTISCLKSLIAWIWTWVINDWIIKDGMLTVFMSIAAINVALYASTILLYMRGKAFRQWIVKADLMGRAGLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R3Z3</accession>
    <name>A0A3D8R3Z3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09335</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cyclase 1 superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R3Z3"/>
    <dbReference type="OrthoDB" id="5396at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007325">
        <property type="entry name" value="KFase/CYL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF10">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04199">
        <property type="entry name" value="Cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102198">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW68678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="37912" checksum="7576F7526AD8839A" modified="2019-01-16" version="1">MSGKSQDRTSIPWDPANELFPLRRDLPKLPDAPEDAAWVWGKDDFCGRLNLLTPARVKAASAEIKTGESAPLDLPTNMPAVPGAGRQEFKHEIKALIEGVAYDDIYTLNTQSGTQWDGFRHGAHISKATFYNGAKVADFIGPSSNEKCSIHFWRDNGFTGRGILLDYRSYAESKGFKYDASSPCSISFDELEACGKHQGINILPARQGGDIKVGDILFIRSGWVQDYNNRTPEENKALAVQEEFSSAGVKQEPKMLDWLHDCYFAAVAGDSPTFERWPTAEAYLLHEYILALWGMPIGEMVDLERVSELAKKNNRYTFFITSAPFRTHGGVASFLNATAIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R418</accession>
    <name>A0A3D8R418_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Luciferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_09328</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R418"/>
    <dbReference type="OrthoDB" id="5561043at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF16">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="7">
        <location>
            <begin position="16"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="458"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="462"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW68671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="487" mass="53820" checksum="081C1BF73F08FF52" modified="2019-01-16" version="1">MGAIEEPSPVKKLMHLNFFDMACAGSHMPYGQWKDPDDISRFKDRLDYYLWLAKLADKGKITSIFFADIYGGHDVYRGNMDAMFKGGANCAMIDPVTIVSAMAAVTESVGFGITGTPYILARTWSSLDHLTRGRIGWNVVTSYGESAAKAMGKDTVPSSTERYAAAEEYLDLTYQLWEKSWEDGAAVWDIESNTAYDPKKIHKIEFNGKYHKMSAYHQTHPSPQRTPVIFQAGASKSGIEFAGKHAEGIYTDMSSKAGLLAHTKAVRAEAVKCGRDPSSIKFFAAITPVLGRTIEEANAKFEKAKRNMTGEVSLAKFSAYTGIDMSQYPMDEPFVFDGNTSAANTITGVIKNMKAKFDQFEGPVTPRMFMESMSFGNSGLTPVGTPEMVADVFEDFFNATDIDGFNVVYVSNPGSYEDVVELLVPELQKRGVMWQDYAVPGGTFRENLHSCPGQTFLSPEHPGAKHRWETKPLTKETKVAPTESVRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7H8</accession>
    <name>A0A3D8R7H8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_08287</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW69890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7H8"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF4">
        <property type="entry name" value="7ALPHA-CEPHEM-METHOXYLASE P8 CHAIN RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW69890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="301" mass="34312" checksum="9D513942E1E5118B" modified="2019-01-16" version="1">MTAANMTTATFKHIDPSSYDPLATEAFKKPWGKVDGPGYSYQLKEYQRAVHDLRGHESDFSIDLSGFAVYNAPAKEKLFIRETDVREGYYAEVEALLREKLPGVRDVVIFDHTIRRRDKDSPRQPVQLVHVDQTPHAAEARVRRHLPTSAVDNWLKGRYQIVNVWRPIENPASDFPLAVIDGRSMDASDFVKVDLLYPKESDRLGEVRPDPNSASSTEGYEVKGEVYNIAPNEKHRFYYMKDMTPDEVLFIKCFDSRSRQMTGEKTDIAHGSGHTAFRDPLTPADAPGRQSIEVRCLVFYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7L6</accession>
    <name>A0A3D8R7L6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mannose-P-dolichol utilization defect 1 protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_08338</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the MPDU1 (TC 2.A.43.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW69941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7L6"/>
    <dbReference type="OrthoDB" id="271506at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000006">
        <property type="entry name" value="mannose-P-dolichol utilization defect 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016817">
        <property type="entry name" value="MannP-dilichol_defect-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226:SF2">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023381">
        <property type="entry name" value="MannP-dilichol_defect-1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="224"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="252"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="269"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR023381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW69941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="292" mass="30523" checksum="FB82876972CFEC13" modified="2019-01-16" version="1">MDSLRAIVQPITHNLPAPIADIGTTLLGEQCYKTLILDVSLDSPDCLKLAISKGLGIGIIATSTIVKVPQILKLLNSKSATGISFLSYLLETSAYLISLAYNFRKGFAFSTYGETALIMVQNVVIAVLVLNYSGQKAAAAVFVAGLAVAGASLFGEGIVDMNMLSYLQAGAGVLGIASKVPQILAVYSQGSTGQLSAFAVFNYLIGSLSRIFTTLQEVDDKLILYGFIAGGTLNAILALQMIYYWNAPAPASKPVKGKEKGKAQAIPMAAATTSGSSVSASKGKSPTTRRRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8I7</accession>
    <name>A0A3D8R8I7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Brix domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_08756</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8I7"/>
    <dbReference type="OrthoDB" id="10261452at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045112">
        <property type="entry name" value="PPAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661">
        <property type="entry name" value="PETER PAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661:SF5">
        <property type="entry name" value="SUPPRESSOR OF SWI4 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="35"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="297"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="306"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW70359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="449" mass="50407" checksum="E3FC9D15CF1EA10A" modified="2019-01-16" version="1">MARRRTKKRTHVGAINNGPQGKQVSANQVSRAPKSMVIRIGAGEVGPSVSQLVKDVRKMMEPGTAARLKERRANRLRDYVTMAGPLGVSHLMLFSRSATGNTNLRLALTPRGPTLHFHIEKYSLCKDVRHALKHPKGGGKEYLTAPLLVMNNFNTPASETDSKNKIPKHLESLTTTIFQSLFPPISPQTTPLSSIRRVMLLNREPTKDGEDGSYTLNLRHYAITTKSTGLSRPLRRLNAAEKLLHSQSKGKKGGLPNLGKLEDIADYMIGNDGDGYMTDATSGSEMDTDAEVEVVDTQTRRVLSRKQQDRARKAEKSGSRSNVEKRAVKLVELGPRMKLRMTKVEEGICGGKIMWHEYINKSKEEVKAMEKVWEKRRQEKELRKKIQKENVEKKKAAKKGGKDNEEDEDDEMVDEWDSEGLEGDGEMAYNEQMEENGEWEDEQEEIAAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8U7</accession>
    <name>A0A3D8R8U7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_08725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8U7"/>
    <dbReference type="OrthoDB" id="5218140at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="168"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="168"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW70328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="405" mass="44614" checksum="FB272765BC769FC3" modified="2019-01-16" version="1">MVDQENTASSKGGFFVKHLWRRSKDKSSAKDAKSMPSTTTLDESNNVEPPVDEVNRKQHRRAQVRKAQLEHRQRKANHLKELEQEIVQLRNMITAVENDGGRLLKENRCMREILSGAAILMPAHISPPRMTPQTELHSFWNCGQGDSLVHTSYDPILKADCLMISSSSSSEGSNVESRDVSVPPSVPGLSGVPGTAEASDAGDSPAIPPVSLDQSDVAVNFILALEAPCRTHFRHNPPTEAPFNPDIPETGHELMASALLYSAAPESAFDFSAQPTECNHEPTSRTLTQWSAPILDISRLYVMSLSLPKGDFEITPVQAWFMMVEKYGLESVMENIEDLKRRIAPYHENPNGPRSAVASLPRMAQFGENTTQKHDTGAVLGSVFNVPFNIQALRVIESGKGLMVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCG6</accession>
    <name>A0A3D8RCG6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Large ribosomal subunit protein mL50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_07766</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL50 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RCG6"/>
    <dbReference type="OrthoDB" id="6220758at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018305">
        <property type="entry name" value="Ribosomal_m50"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10501">
        <property type="entry name" value="Ribosomal_L50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="220"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="220"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="237"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW71732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="404" mass="44710" checksum="E253D67A9B163430" modified="2019-01-16" version="1">MRRISRVDRSIGLMRRSVAANNTYLCAACHQSNLFSTSSPRTLPSDGKAPFTERVRRRIWGTDSPPGLADPYGDASVFDQTKKRAQRSENADDVEARGPQTIVRDMTGYEPAATWDGLDKVGGFGGWWKENWDAENKFRGFLPAERLADIEDVTGALRRAIVESFALRMAGKPLSEISAAEPSFDLTTEVELTPTATGATLQFTEAASLEDIVLSLAPKVDETATKENPTESEEDVAADRSTVDPLEPEHNEEPIDETAVKEQPTESEEMVAADRSSVDSFEDTRMDYEAAIETWGSEWYKVSLADPEIKFAVIKRVMQLTGVRISDHAIQSSGTAYALLTRLATPPKSRKLVDDLAAKEQLMTLPNVSVFAKRVTPIDKERMAGRWKLIEAELEKRGLPITGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDB7</accession>
    <name>A0A3D8RDB7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Inclusion body clearance protein IML2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Inclusion body clearance protein iml2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_08056</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Inclusion body (IB) resident protein that interacts strongly with lipid droplet (LD) proteins. Involved in LD-mediated IB clearing after protein folding stress, probably by enabling access to the IBs of an LD-stored soluble sterol derivative that acts as a chaperone in inclusion clearing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with lipid droplet proteins.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDB7"/>
    <dbReference type="OrthoDB" id="2154985at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019412">
        <property type="entry name" value="IML2/TPR_39"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31859:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 39C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10300">
        <property type="entry name" value="Iml2-TPR_39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="170"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019539"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00043897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW72022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="691" mass="77750" checksum="8FB346C666B206C3" modified="2019-01-16" version="1">MSRWFRSAVKGQNPMKAEDEMRYLRDAEEALMLLLNDDIEKADKILKEQDSSFHLLGRGISAFLASMLGGEKDLMKNAAALLQAAETRTWEDMKRAEKEPDAFQSAIYPPGTEYAVCFSIAMLTSAITSVLSGSITEAVKGFYKLRRAYQTLEGILEIEATFIKRRRANLGTPGSTSTEGLANGAGSRPSSKAGSTKSNSNGVATPGFTSSRNSSDLARTEEELLKAIEAGNPDLSTAQTTSSYKPSRKLDLDPAMISKALTSHIDIFIYSGSHVCFGLLLIVLSMVENPVFNRILYIVGFKGDRERGVEMLWQATKFENFNSATAGLGLLGYYNGLVGFCDILPTDAAAEDDLSGYPRARCKALLAEMVRLNPDSKLWKLEEARSMSFERRLGDAIVVLKENTESNMKQIATINIFEKSLTTMFYHDYQEAADSWLMCAELNTWSPTLYHYMAGCAYVELYRNALLSDPQAAVIFKTKATENIRKAPSFAGKQKVMSKQLPFDIYITRKVQKWEERAKEWEVEFIDAIGVSPILEMIYLWNGLKKMSSVELEKSWIAVQWERTKQPEKFRADFDEAAMHNLLQACTLRNMHKFSEARVILETELLVHDRLKFKGPLKDDWTCPAAHYEMACLAWFEKDLEGVDHTAKVLDCEEWLQKTQTFESYVLDTRMSIKITTSVATVKRHKAIMAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDC7</accession>
    <name>A0A3D8RDC7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphatidylinositol-specific phospholipase C X domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_07962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDC7"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08586">
        <property type="entry name" value="PI-PLCc_BcPLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF113">
        <property type="entry name" value="SI:DKEY-266F7.9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphatidylinositol-specific phospholipase C X" evidence="1">
        <location>
            <begin position="184"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW71928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="500" mass="55233" checksum="3ADE3BDA52E20EF7" modified="2019-01-16" version="1">MASSSKSLACWQLCCCYRPSSATTGLMAPLSIRNFTKTPIELKHLERFESPQSLDNGGGLNSITRSLTTLMSNITTSPTSPQLAAKSESFSHQDVSILVGSFETKPTDIQPNPQEILRLTFQIEGERYRVDTPTPSQRSTVLTPLSPNPSFEFTAVYLPNGSFLAIYSSAKLESWMSKLSNEMPISRLSIPGTHNSPTCHTALPSVRCQAVPVKEQLSNGVRFLDIRVQPENPDNPTKDGLILVHSAFPISLTGNKYLRDLINVVFGFLDANPSETVIISLKREGVGKTTDAQVSKILHDHYATDPARWFTENRLPKLGEVRNKIVIIRRFGLDASLKGDNGWCIDAESWPDNCADGICSSGEIRVQDFYEVEETHNIDKKINFSEAQLARSAKIIAPPPSEVNSTEAAKMPIWINFLSASNFFRPGCWPDKIAAKVNPRIIDFLCKKHNQTEPIAALGAEQRPVGDGSTGIVVCDWVGEKGDWDLIRCIVGMNTRLELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDG4</accession>
    <name>A0A3D8RDG4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">U1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_07948</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDG4"/>
    <dbReference type="OrthoDB" id="191651at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040023">
        <property type="entry name" value="WBP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173:SF10">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="U1-type" evidence="6">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="197"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW71914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="285" mass="32025" checksum="FF888A4C6EC64FAD" modified="2019-01-16" version="1">MSEYWKSTPKYWCKHCSTYVRDTPLERKNHDATPKHQGNLKRFLRDLHKNHEKDEREKQRAKAEVARLNGVVAGAGSGSSTTASSSHSFSPASRQPATSAQIIQQREQLSELGVAIPDEFRREMAMVGDWQVTSERVIESEDREKKPDAIGFGIRKRPAEDEEEEEAIEVKKARWGSAYRTHPVGDDEDDLDALLDEATRKGKEPAVKADPEAAIKAEADSEEQIKAEDDTKKLSDIPQVGNADERVESDQPEAALSADLAASDAKHNLREVVFKKRKAKNIRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDG5</accession>
    <name>A0A3D8RDG5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flavin-nucleotide-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08109</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDG5"/>
    <dbReference type="OrthoDB" id="444432at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024747">
        <property type="entry name" value="Pyridox_Oxase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34071">
        <property type="entry name" value="5-NITROIMIDAZOLE ANTIBIOTICS RESISTANCE PROTEIN, NIMA-FAMILY-RELATED PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34071:SF2">
        <property type="entry name" value="FLAVIN-NUCLEOTIDE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12900">
        <property type="entry name" value="Pyridox_ox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW72075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="28980" checksum="65CC075E651B1F00" modified="2019-01-16" version="1">MADSEAYAKHPRSTVNRYGKPRGRYDYQTIHSVVNTVPVFHVSFPTPDEDDPFPAMIPMLGFMGDFSAPGSDDLARPLDLYLHGYISSRLMKLGGTGDGVHEGLPLTIAATHLDGLVLALTPNHHSYNYRSAILHGFGTAVTDADEKMWALEKITNAVVTDRWQNTRLPPTKAEMISTQVIKVSVVSASAKIRAGMPGDDRNDMKNDELRAKTWIGVVPTWTQYGQPIASPENRVKEVPAHVRDFVKAVNEREEGTAKDAALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDH8</accession>
    <name>A0A3D8RDH8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal RNA methyltransferase FtsJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_08012</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDH8"/>
    <dbReference type="OrthoDB" id="417125at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="2">
        <location>
            <begin position="386"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW71978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="663" mass="73741" checksum="3A82EEED9BAF7622" modified="2019-01-16" version="1">MPRFNNTACALLAPSPVNTPELGHVGTSIDTTSLDPVQTSREASTISSLPGTPRRLSTMYGSAAGCAVAPKMVISSSALDPKNAVDDRRNMAANGVPLSTGSTIHQPKFTSKHCIRTSSPPPAPVQVKLPKYKANELYINELGQLVPYQEILHAVSDTSANVLESAVAVGITTKNASVSEPEVPTETDQHPSPSGPDLLVTELTMEDATRDYVTSRTFGTPTDSVDGIFLSKDTAAGSGAEKPTNTSKSQEECQPSETKQTPDLPNLFALTITPGRDRNMADLERPVTDFIPRIMPANRHLEGCNRYVYDFLMAQEPEYARVADYRARGWQNEKGDEVFKRQREKADTTGPEGEKAIFKIMMDIGEELQAFANIYLPQVVLVRPLIVLDLCMAPGGYSAIAMRYNALAEVYGITLPPQQGGHPVNTDVKARVKGLKFCDLTMIAGEFTNQKIPEEHPEYKSFNRIRPFSKHKFDLIFCDGNVLRTHQRPEYRKQREIETLRLNCSQLILALQRVHTHGTLVMLLHKVDYWDSLHLIYSFSKFADVSLFKPCRAFKARGSFYMIAKNIRPEDPAAQEVIRSWKEMWWRATCGEGQDLKPVVTEHKKEYVLKVLEEFGERFIELARPVWKIQADGLSKTAYAGDGSSFEAQKKTTNVDQPDASLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDW8</accession>
    <name>A0A3D8RDW8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08269</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDW8"/>
    <dbReference type="OrthoDB" id="4158087at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW72235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="587" mass="65766" checksum="D2937168B626E557" modified="2019-01-16" version="1">MTRSHEDHTPGDVLMSTTGARTRGLSPPAPVAAPSIVVFNTSGTGSSDPVLCSTSIPTSWADAKLTGFVKRGRPRKGRKTAPRSSEKTKGLGLTHSNNKSDFNFINCTPTTQISHPEIRKVVRSNAMLHFRRLGRGSLYPCSRIRQDHDTEPIEEVSAVNSSSGSLDVAETEEGHWEQSKLKSNEQQQDGTLDRRVRSVLVSALTLPLEIGDTDPFDVFPLKIKPYMLDLLTKYATSIYETMYSIEKYAAINPVKECWLPMAFQDGALLHTILACADIYGSPYWMNHPTALMHISKAVTMVSERLLGPTPEITDATIVVVCALAYSEMVNNNQENWRVHMRGLKQMVHLRGGIEAFESTPMIQNKISRADLCGSLSAVQKPYFDFPRECLAIPPLSNHMTHFRGVRSAVELDNRLLQILWHVEHAVFNLNRIHINKADIHPMAVRKEITSLQYALLSFGVRRNDVREELMHEVLRLSMLVYLVIVLDESPPGLPIYKMLGVDLVAALKELGLESSLEPKFLLWITFVGASFDQNAQNSDYFMASAAKMSKRLGISSWESAEVVLKSFFWVDKTQSYSFSRVWDSLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDX5</accession>
    <name>A0A3D8RDX5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Solute carrier family 2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_08125</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDX5"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF11">
        <property type="entry name" value="MONOSACCHARIDE TRANSPORTER (HXT8), PUTATIVE (AFU_ORTHOLOGUE AFUA_2G08120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="299"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW72091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="478" mass="52501" checksum="FE532D481C357A68" modified="2019-01-16" version="1">MKGFDTGIATTTIAHQSWINYMGHPSNGLTGAVVAVYIAGEALGALTQTAIGDKLGRIRFMQMMCIIATIGTAIQTASVNIGMFLAGRVLAGYAVGGLVATVPIYLSEISAPNHRGLIGGISGCGISFGTMMSNWVGFACGYAPYGSTQWRLPLGLQVPWGVILFVGLATFMPNSPRQLIRIGKVEQARKEYSRIHRDLASQEVQREFAFMLAQIEYEMQRELTSLGEIWKLYRHRVLVHWRADDDESDGGECHSAILYKSLGINSHTILALAAVYGTIAFASNAITTKYLTDQWGRRNMILTGLAGIIVVEIYAAVMQREFQNTNNKVGKGFAILGIYLFVVTYYGMLNSTTWLYGSEVLPIALRSKVMGLAAASHFIVNVAVTEAGPSAFANIRENYYYVFVACSFFFLVLAWFYFPGNPNSETKQKSLEEIAAAFGDKVVEIGEREMLDAGVKMDEEKMEMEEGRNAHLEDVRGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RID2</accession>
    <name>A0A3D8RID2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatases II</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_07245</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RID2"/>
    <dbReference type="OrthoDB" id="10253954at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18533">
        <property type="entry name" value="PTP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050348">
        <property type="entry name" value="Protein-Tyr_Phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000242">
        <property type="entry name" value="PTP_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003595">
        <property type="entry name" value="Tyr_Pase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134">
        <property type="entry name" value="RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19134:SF449">
        <property type="entry name" value="TYROSINE-PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00102">
        <property type="entry name" value="Y_phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00700">
        <property type="entry name" value="PRTYPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00194">
        <property type="entry name" value="PTPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00404">
        <property type="entry name" value="PTPc_motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50055">
        <property type="entry name" value="TYR_PHOSPHATASE_PTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="3">
        <location>
            <begin position="253"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="4">
        <location>
            <begin position="434"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="124"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW73803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="553" mass="62654" checksum="8352235EBEC92645" modified="2019-01-16" version="1">MSTRTYAFPLCRPSGHFFALLGQSQPSPRNSFSSLLTPCLNCLCVRHNYLADVFLGIAFGLQQTKVSLISISSARTARVASNLIVDRLRAFRRHRHEPEPTPVRSNPSVPGREAPCPNLAVETGENSSQQSRGRSPGWLSKMHRNRSASKKRSRSPSSLPSTPVSGRQREPLPKMTEIPGTNGTRSSKSSPGTRPADVEPPAQKIPAFLQLTTEERHAKFLELNQLEMGRLREKRDPTMESPWSYLKIDKTLDRYNNIHPWYNNRITLQVPEGFNDYINASPVALSSDTRKDHAPHKFIAMQGPKKETIDHTWMMIWQSLSNPSTTTPGVIVMLTPTHLNHPEDPSIILMEKCYQYYPIDEESEPLQINDTSVLGEQFKATVRFVSREETTQGDAIELRKLAMRVEGSDEEKIIWHFLYPGWPDYGALEEEDVDSIIALMHLSREKNASPENPRIVHCSAGVGRSGTFIALEYLLGELEAGAWEKWDDDEADPIFETVNTLRMQRRTMVQAAEQYDFLYTVLRRFWDEKYGEQAIQEPASKMAKLAVDGSVFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RID7</accession>
    <name>A0A3D8RID7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UDENN FLCN/SMCR8-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_07249</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RID7"/>
    <dbReference type="OrthoDB" id="5599713at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037521">
        <property type="entry name" value="FLCN/SMCR8_DENN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021713">
        <property type="entry name" value="Folliculin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037520">
        <property type="entry name" value="Folliculin/SMCR8_longin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31441:SF2">
        <property type="entry name" value="FOLLICULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31441">
        <property type="entry name" value="FOLLICULIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11704">
        <property type="entry name" value="Folliculin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51834">
        <property type="entry name" value="DENN_FLCN_SMCR8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDENN FLCN/SMCR8-type" evidence="2">
        <location>
            <begin position="203"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="358"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW73807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="452" mass="48696" checksum="AEE3F7D57E03B2A8" modified="2019-01-16" version="1">MVTEGQPVGCETCFDEDDSLSVRRPSASSAAASSSQERRATAKGTTDRARSSSADKENRPQSTPLRDNHANLPGTPPAVETPPESPRVLALQSTQRTNSGRRDSSFRKTYDENDQKRAIPCDNCALTLPKKTKTSEGNAKAGRVDSQPILRTRVPYERVTSPGPRSSEISPPKSATSDSSDSDEAGSSEEPRRPSRGITRTATSSSSSSFSSVAHEHNMEYISTHEPLSPTSFSIIRQSCLRTLSCETLPPSSNPTSAVSSPTSPIVNNPFSSGPSAPSTSSGGPILFGDPLAGYTTAYIFRIPDPTSRGRRRVYAFMALSTHREQLAVKAFSHLSNAFRNLAQWITDLAARELERIQNSSPNPSHPSYNSSAQSSFSTNSLNYPSGNGGSSNTSYHTPTSSFLSSRSNASSYMGSRGKGLAELVGLPDFFFELHRRFVLLLVELGLLLNHP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIR6</accession>
    <name>A0A3D8RIR6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_07288</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIR6"/>
    <dbReference type="OrthoDB" id="1049195at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000145">
        <property type="entry name" value="Putative RNP domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000280">
        <property type="entry name" value="RNA-binding domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF3">
        <property type="entry name" value="FI21236P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="191"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="354"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="435"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="444"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW73846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="454" mass="48443" checksum="D4C3B5BA9FF8CDE7" modified="2019-01-16" version="1">MLQRERTRSPRRARSRSPGRSTRRRSYSPRSRSRSRDDHRRNDRRSRSPMSGAGAGAGAGGSGSSGYGGQPPRSFEDRAAAREQMMSSIRETSQQDRRVYVGNLSYDVKWHHLKDFMRSEYATREQAQQAVNTLSNQNLMGRLVYVREDREAEPRFTTPSTARGGFDGGPGRGGFGGGPYGGGMGGGGGGRQIYVSNLPYTVGWQDLKDLFRQAARNGAVIRADVHVGPDGRPKGSGIVAFESPDDARNAIQQFNGYDWQGRPLEVREDRFAGSAPGFGGRGGFGARGGFGGGFGARGGFGARGGFGAGFGRGGYGGGGYGGVGGGFDAGGAPAPSAVPNPFTDYATAGTDRSETIYVRNLPWSTSNEDLVELFTTIGKVEQAEIQYEPNGRSRGTGVVRFDTAENADTAIEKFSGYQYGGRPLGLSYVKYQTPGSGGDAMETEATSLTQDQIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIU3</accession>
    <name>A0A3D8RIU3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">6-phosphogluconate dehydrogenase C-terminal domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_07407</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIU3"/>
    <dbReference type="OrthoDB" id="9988102at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015814">
        <property type="entry name" value="Pgluconate_DH_NAD-bd_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF2">
        <property type="entry name" value="CYTOKINE-LIKE NUCLEAR FACTOR N-PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09130">
        <property type="entry name" value="DUF1932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="3">
        <location>
            <begin position="7"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphogluconate dehydrogenase NAD-binding putative C-terminal" evidence="4">
        <location>
            <begin position="223"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW73965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="335" mass="35557" checksum="4521E1004D0B141A" modified="2019-01-16" version="1">MAKVATVGILSIGEMGMGIAKLLIAHNYHVVTNIEGRSEDTHTRARQSSIETLPTDTALVQRADYILSIVPPRDALATAQRITTAFSSLGPEGKPTPLYYLDLNAISPRSAREIAAVFHSAAPAIRFLDGGIIGGPPSLAASATKENTTSNHPETTHPWKRPSIHVSGSHPLSSAPIAGANLEEVLNSKHISAEIGPASGLKCCFASTSKGFTAICIQAFTTAAQLGVLEELKEEISTRAPGLFKAGTNGVTSMPPKAYRWVREMQEIAVTHADDGGFEGEGMGIFDAVARVYDTVANETVLGEEKTERRKRGRTVEDVAAAMGEGLAAKKMKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJH2</accession>
    <name>A0A3D8RJH2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_07634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJH2"/>
    <dbReference type="OrthoDB" id="3799661at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="334"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW74192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="352" mass="39439" checksum="DC4CE2112522AE7D" modified="2019-01-16" version="1">MTTFKISTGHGLVSSNSPDSLDSTPNPRGTSVESTRSRITLVADDPDTASYQAAKLKEIDEVVRGIYRRKYTWFQHLQAVFCIKTNQEEDAAANVKYIQTQVLEAINEMDHTSPWVLPVFVLSARVDIDKHRLPQQAKCTIDTGNQQGNLVSQDFVENVLEYSKANFHSLTEEEQMGGIGVTGHTLVPIGAIYLTWYHKKSTRVFRDMRFLISPIKDYDLVIGARSIQKDRLLSIPNLMSGSAGVVFTTQRDSEVLEDTGKDNTEKAIYEKSKEINKVKNSLSRATDPAKKEKYQNELDKLTQDHALLEKNRKVKNDPTMDSEEVDETTELDGKTITGSSETSSTSAKIKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJK9</accession>
    <name>A0A3D8RJK9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_07473</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJK9"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000145">
        <property type="entry name" value="probable ATP-dependent RNA helicase DHX40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF118">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="149"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="468"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="371"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW74031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="908" mass="100059" checksum="2778449F021D34B9" modified="2019-01-16" version="1">MPPKLHNKFQKDAEPAQNIGSHSSTSGPAATKKSPAHHGANGVKRMRDGSPKQNSKPQGSPHTNGLKELGLVNDVKSTGSRGTQDSPGLGKKRISSSGSSKGEQITKRNGEFRDKAGPSTSNRDLERTAAKLLEVRKTLPIWAKKADIRWSLRNNDVLLLVGETGSGKSTQVPQFLYTEPWCKKQTVKVQNKDGILEEVSVGGVIAVTEPRRIAATTLAQRVAREVGSHLPNSGSGDRRTPGKVGYSVRFDSNLPVGYKIKFVTEGTLLQEMLRDPHLRQYSAVVVDEIHERSVDVDLIAGFLRQIVHGDKSGRGGVPLKVVIMSATLDLGGLESYFSRPETVPEYEPGKNHQRVFAEHLLEDQRLKLTIGDDQSRRTSTDSESSYPSWGGIDSSDEADANSQLTDGNEDAKQFALAQKKKSRTPEKVSGIPDGDIHESGVAVEYVQGRAYDVEVLYRPTPTTDYMESMLKTILQIHTSEPLKGAGDILAFLTGQEEIEALRIQLEHYAGQLVKSVPRMKILPLYGSLPASAQQEAFEKVKEKFTRKIVLATNIAETSVTVSGVRYVVDCGKAKVKQYRPRLGMESLLAKPISKVSAIQRKGRAGREGPGKCYRIYTENDYSKLDMDELPEILRSDVIEAVLKMKARGVDDVLSFPLMDSPDLVAMEKALLQLHLMGAITDDGKLSDTGKKMAAYPLPATYGRVLIAAAEPQADCLLEAIDVISCLTADAEIFMQAQSEEERDDIGENRKDLQRREGDVITYLTTVQRYAAEQTDRTEWCKNRLVSIRAMKMAMTIRKQLRTLCVSQKLLKDMPPSDPQPFEPISPERAEVLLRTFLVSFATKTAVLAPDGSYLTTQGRNIIAIHPSSVLHGQKKEAIMFLEHVWTAKNYAKKVSAIQANWIVEALGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJQ2</accession>
    <name>A0A3D8RJQ2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF6594 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_07642</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJQ2"/>
    <dbReference type="OrthoDB" id="5342093at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046529">
        <property type="entry name" value="DUF6594"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502:SF5">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34502">
        <property type="entry name" value="DUF6594 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20237">
        <property type="entry name" value="DUF6594"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="357"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6594" evidence="3">
        <location>
            <begin position="53"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF20237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW74200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="377" mass="41946" checksum="D6BE8CB06844A3A7" modified="2019-01-16" version="1">MQSLSPTTDSSTGSDTAFDTPPDSPASTGRQSATQTCDPPDANGDTNNPTEGWPLLAKLMETVPEFAILSRFEVLNLKMLLYYQAEIKRLEKNLDELEKSDHYHGKGDLKDFACDLGSLIPVGGAAASKQWTLVQRIQTLLYKYNKALLQVSQIAALPEPDPQTVESLRLWLTRTNGGDYSIVGLGADTWGDIFTEEEKDQKLIPHLLQVLRTLFWKREPTNEKYPLVKSRMVAIKAPTKLDGFTEWVVREWIPFWHKQKPKSKAIRKASGDRDAEKGNRIAKSNNFPNTITQYSENSILRFTCSVATIVACLLPTLGIYIISTVDSIHIRIVYIIGFTALFAMALVFFTSAAHPKISIFTATAAFSAVLVVFVQNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RNW2</accession>
    <name>A0A3D8RNW2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_06405</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RNW2"/>
    <dbReference type="OrthoDB" id="4676at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03884">
        <property type="entry name" value="M20_bAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010158">
        <property type="entry name" value="Amidase_Cbmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01879">
        <property type="entry name" value="hydantase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494:SF5">
        <property type="entry name" value="ALLANTOATE AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494">
        <property type="entry name" value="ALLANTOATE DEIMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001235">
        <property type="entry name" value="Amidase_carbamoylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW75584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="432" mass="46912" checksum="C0A3B20818596993" modified="2019-01-16" version="1">MRVTFSRILHRAQAGSSLRGKLPSSHRPFTATRSRYVKTTDLSEEQLSGVKINRERLWKDIHHTCEWGKGERWGDEPTDVGMHRLALSDADKQARDWFVETTKSLGCKVTIDEMGNIFAIRPGLKEGLATFAGSHMDTQPTGGRYDGILGVHAGVEALRAMNESDIETEYPTGVINWTNEEGARFPISMIASGVWAGAIPLEAAYNLVEVGGGQATQKSELERIGYLGPLKASHTTNPIAAHFELHIEQGPILEQSGGKIGAVEGVQAYKWYVITVKGADCHTGTTDFKNRSDAMLTAAKLIVHSHNEASRLGCLASTGILNLKPGSTNTVPGFVQFSLDIRAGEDARLLELEKVLKSDFQKIAAGEDVGDMNTKGTRGRGCTVEWKLDTDSPATKFSEECIECVEASARGMLGANADTQVQRMTSGAGHDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RP70</accession>
    <name>A0A3D8RP70_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BP5796_06688</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Single-stranded DNA endonuclease involved in excision repair of DNA damaged with UV light, bulky adducts, or cross-linking agents. Essential for the incision step of excision-repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the XPG/RAD2 endonuclease family. GEN subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="31113at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048256">
        <property type="term" value="F:flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09904">
        <property type="entry name" value="H3TH_XPG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09868">
        <property type="entry name" value="PIN_XPG_RAD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000025">
        <property type="entry name" value="DNA repair protein RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000030">
        <property type="entry name" value="Flap endonuclease GEN-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000061">
        <property type="entry name" value="Single-stranded DNA endonuclease (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001044">
        <property type="entry name" value="XPG/Rad2_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171:SF7">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02809">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00066">
        <property type="entry name" value="XRODRMPGMNTG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="17">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="16">
        <location>
            <begin position="933"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="115"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="350"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="528"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="599"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="739"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="841"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1170"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="889"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="356"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="746"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="758"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="852"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1171"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1196"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1222"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1248"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1267"/>
            <end position="1278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDW75867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1286" mass="144049" checksum="D211428B4F3AF67C" modified="2019-01-16" version="1">MGVTGLWSIVQPCARPIKLETLNRKRLAVDASIWIYQFLKAVRDKEGNALRNSHVVGFFRRICKLLFFGIKPVFVFDGGAPVLKRQTILGRKKRREGRREDAVRTAGKLLAVQMQRRGEEEAEKRKKERGLAPARTTVEDGEEPLPADLVYVDEIGMSNTERQKTRQFRKTDAYHLPDLTNGIEGMGQPNDPRIMSAEELEDYARQFHNGEDVNLYDFSKIDFNGEFFMSLPAGDRYNILNAARLRSRLRMGLSKEQLEEMFPDRMAFSRFQIERVRERNELTQRLMNLNGMNDVDTLSGSGRIAGERGREYVLVKNDGVEGGWALGVVSTDKSVGERNKPIDVDALHQEVKRDEIEESEDDFEDVPVEGLNRLPKLKTDGSQNPTYDSFQAQELARQRKQLYNSRNEAGPSKRQRTEAEDTDSLFVDSEMPVVSNPVYDSEEEDLNRAIAMSLQKEGSPAGDSDENHLNEAIALSLQKNHRQEFEVEDDFEDIMMPQYEQRAVEAPKPIINNSGRMVAHIVNNRANAAVPKRRAAESDESDSDMDLQSALAAARKQKAPARRSKLAPIPTNQKNPFDGPLPFEKLDFKSSIFGRKLHGTKAVEKAPEGEDVDDEAGGFENGPAEEAPKPLPPWLVGSGDIRSQVEEQQKRDLELNNADRERAIEEDRIFQRDHGIIELESSDDNDSDVEIVSAPSPRLQATATMKDFAEVARANPTMGEIAEDVQGGLEEDEVLPQIEVNGNDGEVVDWSESEYEDNVVKERKAIDDTPLTEKHDGTDSPKSPSPEFEDVEVPEPPSNMEDSLHSELRPSSISPEFEDVSMPDAGAAFSSSLHEVPAALPNEDTFDRQDNDGENVDFGDFSDPEDEELLAQLATEAEEHARFASTLNNKSERENQEAYERELKQLRSQQKKDRRDADEVSHIMVTECQALLRLFGIPYITAPMEAEAQCAELVSLGLVDGIVTDDSDIFLFGGTRVYKNMFNSNKFVECYLSADLEKELSLSREQLIAVAHLLGSDYTEGLPGVGPVTALEIISEFPSAEGLQSFKEWWAASQHSKKPLPEDIGSTFRKKFRRSQATKLFLPPAFPSPAVTEAYMKPDVDSTPEPFQWGVPDLDRLRDFLMATIGWSQERTDEVLVPVIRDMNRRETEGTQSNITRFFDGGVGLGAQSIAREKDIGSRRMKDAVSKLRARKSGSARGSTPALSSTFGDEAAEWARTNDLSFTEREREKSTKGRGKKGKKTTSVAPEVEIEDADDESLGVENDNVEAENRNVGKDKASGKRKRTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPB1</accession>
    <name>A0A3D8RPB1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative dicarboxylate carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_06666</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPB1"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="55"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="9">
        <location>
            <begin position="153"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW75845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="246" mass="26232" checksum="27DC59A0634EAA66" modified="2019-01-16" version="1">MSTFASRDGIPSLWAGISASVLRQTTYSTTRFGLYNYLARALKQRSGSVELSAASTMTCAGVAGGIAGLVGNPTEVVLVRMCTDGVKAPEQKYRYHNALNGLLRIAKDEGVQTFTKGIGPNVIRSVLMNVSQIAVYTKAKSQLLSSRVLSLKDGLPVHILASLAAGTVATTVCAPADVLKSRLQSAASVKGKRVGMLSVITESMKNEGPGFLMKGWTPAWMRLAPNTVLMFIFMEQLQKLVIGTGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPF0</accession>
    <name>A0A3D8RPF0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_06649</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPF0"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050956">
        <property type="entry name" value="2C_system_His_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058846">
        <property type="entry name" value="PAS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013767">
        <property type="entry name" value="PAS_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719:SF30">
        <property type="entry name" value="TWO-COMPONENT SYSTEM RESPONSE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00989">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26131">
        <property type="entry name" value="PAS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase" evidence="5">
        <location>
            <begin position="818"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="6">
        <location>
            <begin position="1141"/>
            <end position="1273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1108"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="629"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1108"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="1202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW75828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1276" mass="142517" checksum="2611C9ADBFA2B64E" modified="2019-01-16" version="1">MRLEDVLDSPHRPRRASTLPHSTSIVSSYSAQHLFKFSGRFLQLQRLRATALPHTSQAFATFVPATYKALGTIAEEVDFEGRYRIEGAIQLWPSMARLSLERDASLEDFQLVGITELLDGDKRPVCIIDRKKELLQEPVYANASFLRLQASTGKAFDSKTNGFHEQLPNEQYTELVRWIISSQTDDDVASYGDHRWTVQTLRERWRVVSGYPTLEGSSGTIGKRPAAVGAQTTVADKSREVFTLANSLTNMLAPNESIQPRSSDFNLGGGQGQSEEHGKLLELFDPNCSNIHARMTAHKKLVLEFDWGSTDLGPISSWSLELQRSCDFLLSDPRPAALYWPESRAMMYNEAYSQIAGQKHPHMMGQPFNVFWSELGDDFFKYMDDVYANGVAVTQEDNLYYLNRNGYIEETYFSMSLIPFATGDGRVACYNSAYDCTRQVIADRRITFLLRLSQSIASSKEPKDFWSQLLKALECNTFEIPFALLYSAGGESNETLSECSEQSSNIELWSLEGTVRVPSDSSHVPKRLNFECPVENFIKHFQKHLKSSDPTLLQVSDGTLPTGLLEDLRSSGAEICDSAIFLPIRSTGENVLGFLIVGVDSHRPYDADYQLFTQLMTRQLTNSMATAVLFEEENRKARAAAEMATLDRNRLTKQLAATTQEAVAADHRFRRMADLAPVGMFHIDPQGILLYANEDYFVMTQHPRDPKPQAMSWYDVIAEIDHPRMDIEWAKLLGGDPVSFELRLKTQFVPPEPANDDTFLNTWIIAAAYPDKDESGNVVGILGCLTDISRQKWAEGIQARKRLEALELKRQQESFIDMTSHEMRNPLSAIIQSADSISNSLSAMINSPNPMIEISRETLENHIDAAQTIVHCGQHQKRIIDDILILSKINSHLISVTPVEVQPLLVIKNALKMFEGELQTNDMELKLEVEESFSELSIDWLKLDPSRLLQVLINLTTNAIKFTIPEAEKNITIRVGASQTPPASTNGVEFLAREPSRKDLSFGLDWGSGETVYLIVQVQDTGRGLNEHERKLLFQRFSQASPRTHVQYGGSGLGLFISRELTELQGGQIGLLSEAGVGSTFAFYVRARRCSPPQCAIPLVEIDTQAQPNAATSSVPTGPQAEPTRAQSSQAKSNKVTVIRNVLIVEDNLVNQKVLSKQLRTAGCTVYVANHGQEALDFLQASEYWKDSTEGKVLPNFICLMDLEMPVMGGLACVRRIRELQNEGTIIGHIPVIAVTANARSEQIAVAREAGMDSVVTKPFRIPELIPEMDKLLGQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPF3</accession>
    <name>A0A3D8RPF3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_06754</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPF3"/>
    <dbReference type="OrthoDB" id="4480814at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G07470)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="498"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="528"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="573"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW75933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="684" mass="74425" checksum="C73A0848DD04C325" modified="2019-01-16" version="1">MPAHSIGWYNPVYSTFGFSERTRRRLIAQWLSPGLVVRETTIIEKMVDLAPLRMQAYSIVDDAPQERVEKSRSYAQSMTVRGSRVEQCRWAGRSKRWECAADASLDANRTERRDRPARNDLMSQIVIYNRHTPPSPPSALLPPTSAVQALETAQVLHLRKVIVGDRPKVMTRLWPGFDLRPRHDTAMGKEKERSAVENDTIVSLIDSPTIVHGAFTTPSREEISVDLRHPSATFLATNPCLGATLESFADCADLAPRLTPERPVHKHETNLLSSTSHSTLTRLQTPSNPQPSSLLSLVCVLSFAIRQKTSTTTVVPCSIDPEKKFVVTMGAGRFLCVALPFGLTVASLICILVAMLAGVTNKNLEMFNINTANLSISSSSLTNLASLISRDNHYYNNALLESMARAATSGSSSSSSINITASDLGLADSYRVTLWNYCSVTGTNVTCTKPAFNWAATALNTSSISSLASSTTGLTVTLPTEITTALKTFTTVEKWTEVVYIIAIVATAVELILGFFAMCSRVGSCCTFLLSGFSTVAIIAASIMATILSSTVVGAVDTAAKAYGVHSSLNTQFLATTWLAVAFSLASGLFWMFTICCCGSDHSSRNKSSRKPWGRDRDTEDAEKMIPVGAYQRVGGPDTTYAGQQHGIYNQQTGVHQGQYGVPMNNIKAQRSQQGYEPYSHTAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPQ5</accession>
    <name>A0A3D8RPQ5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_06878</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPQ5"/>
    <dbReference type="OrthoDB" id="10543197at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="350"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="217"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="386"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW76057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="553" mass="56615" checksum="EF1C9185EDA6BC72" modified="2019-01-16" version="1">MAATEGTLDAEVDVAWTIEERNRSPTSKPSRRKETLNSVKARRSAPHLPEILVFGTEDHLMARAVSPYSNAAINPREGNGDGGSGGNGSGGGQGGGGGPDRGGGNDPAQRNPPGPGDPPPTPGEPGGKGPSKPQPPKTPKPKPTEPSTTKSPTTTTTSESKTTPKPSPKPAAATTSQTKEPFTSTTSSTSLSTTSSTSTSTSTTSTPTPAPTPTPTPTSTSTSSTSTSTSTTSTTTSSESTSSDSSTSLVPTSTPAAAAAASTTDVPNPSVAALPDEASSVSSSVASTPTPPPAPTMNAPKEPPPTPPLSTPLATPPAAAALGSSSVSTPLSVPPPPAQQIAGTKDLDTMGIAVISSVVVVGCVLLATAGIYIWRRCSRLKRAHDAKHEKDERRFSTESITRPSSPYPQTPTVSASPPLLPTLQTSFPGPSEKTVTPPVQATPLPIRIPPNAYVARFTHRISSFFFSSSSARASTSTIGDDPFQYSSYLSPSTKSPVPDQSPSSLDPNNEKAADNTNDDQNLPLPKSPSRERVHTFGDQKPQESFNFGLGTAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPV1</accession>
    <name>A0A3D8RPV1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF1446-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_06797</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPV1"/>
    <dbReference type="OrthoDB" id="10265871at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056362">
        <property type="entry name" value="AtuA-like_ferredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585:SF2">
        <property type="entry name" value="DUF1446 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G11420)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23544">
        <property type="entry name" value="AtuA_ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyclic terpene utilisation N-terminal" evidence="1">
        <location>
            <begin position="11"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="AtuA-like ferredoxin-fold" evidence="2">
        <location>
            <begin position="504"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW75976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="614" mass="68098" checksum="ACBB75E9A69BE5DB" modified="2019-01-16" version="1">MAATVTPKRPIRVLNISGAPVDRRDAMANAAASDEPVDVLVGDWMSELNMPSKSYLLSEGLSPGYEQSFVESLEPAIENIAKKGIKLAANAGTVGTKALYDIVVEMAKSKNLDLTIAWVEGDVVLEQVQTALKEGTHDFVNFITKQKLKDWPFKPLFAQCYLGGLGIATAFKEGADIVICGRVADASPIIGAAAWWHDWVAEPSKYYDELARSLIAGHLIECSTYCCGGNFTGFKSLDWDTIAEMGFPFAEIAHDGDVIITKQKNTGGMVTPETCKEQLLYEIQGTYYYNSDVIAKIDQVEFTQVAKDKVRISGVTGVAPPPFTKVGITAHGGYRAELHYCFVGLDIEEKAKMTEIQMRKSFGEERLKKFTTWEFTINGSVPVNPRNQASCIVDARLVAQSPEEEALSLKNFCAPALDIVMEAYPACTFQRDLRTAEPQPYQEYFVSLIPQSFLKQKVHFSTSGKASIDIKAPEITSSLDAQQPSYPPTNPVDLATFGETVEAPLGYIVHARAGDKGSNCNVGFFVRHEDEWDWLRSFLSTERLIELMGEDYVGQKIDRMEFSKLWAVHFLVHDHLDRGVNANTTYDILGKFLSEYIRCKPAPLPKKFLDRGKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPZ0</accession>
    <name>A0A3D8RPZ0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_06837</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPZ0"/>
    <dbReference type="OrthoDB" id="10339102at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017579287" evidence="1">
        <location>
            <begin position="21"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW76016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="79" mass="8924" checksum="5853C305756D312D" modified="2019-01-16" version="1">MKLSTLAAALAVFSVQAVLAAPTAQPGANAATPAEKRQYKDDSFLYFEDYVESKKDKRQYKDDSFLYFEDYVESAKKDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVM7</accession>
    <name>A0A3D8RVM7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ricin B lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_05852</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVM7"/>
    <dbReference type="OrthoDB" id="5383818at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW78000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="507" mass="50791" checksum="2306BCE1FFF6AFE0" modified="2019-01-16" version="1">MSNSSKDQGPRREKHSSVQLPSEFDVAAAGIDVSEHKTRRRPSQAACLPQHVLASDSPTATPFTTALPGLALEARTVTALNTAAFDEAQQRDATATRAFSSTTIKTSTGQCLSVDELSGDFRANLTPIQVKDCDGSTGQAWDIITNGKHDDQAGTMLIVNTLTQACMNFDPRRAAGNTVIMFSCGGRADGGGAVTNSQLFNFTGASGPLSFTPLNAVGTCLAVTSNNVLDQATCSTGSAGQTFTFGGSGASSAAATTTAAAGNASTIVAGAAASTSCACVVTTMVTVTRQTGTSTTANTQAASTTKAASTTAAASTTAAASTAAAASTTVANAVSRAGGVLNPSAAAEANPRDDTATRAFSSVAIKSSSGQCLTIDASAGDFRENLIPITLSACTGSAGQQFDFITAGQHNNIANSTLVVSTLTQGCVNFDPRRAAGDTVIMFSCGGRADGGGQVTNSQLFPFAGTAKSIVLAPENANGATCLVQNTAGKLDSAACSGGSEQAFTIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVP2</accession>
    <name>A0A3D8RVP2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_05786</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW77934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVP2"/>
    <dbReference type="OrthoDB" id="3556830at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020999">
        <property type="entry name" value="Chitin_synth_reg_RCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28187">
        <property type="entry name" value="PROTEIN RCR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28187:SF1">
        <property type="entry name" value="PROTEIN RCR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12273">
        <property type="entry name" value="RCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW77934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="175" mass="19298" checksum="40ED9C3BDE0A3D8D" modified="2019-01-16" version="1">MAPSSENLRALAARQTIDNNNNLSCDYYGGCYSTWDTWGRWVALVVIIVIFLLIALAFSCVNNRRRRRRGMQPMYGTGWFAGKPPVGHYQNAPGYYGQPQPFYGAPAPPYTPSPMGDQMTGNTFNSNEGYYGHHAGGAYELQPPSSAYQPQRGGDPVYESPTGPPPDRKGNAIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVR4</accession>
    <name>A0A3D8RVR4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_05806</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW77954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVR4"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000263">
        <property type="entry name" value="Carboxylic ester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017635744" description="Carboxylic ester hydrolase" evidence="4">
        <location>
            <begin position="16"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="5">
        <location>
            <begin position="34"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW77954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="576" mass="63525" checksum="A1624C23E51DDB78" modified="2019-01-16" version="1">MPSLFLLALPVLGLALFLYAPLQDQLQAFFPSVSPQIRLSQGLVLGTIVNDGFPKPVEAFMGLPYSMPPTEDRRFRPAVPLPASNRTFVAKKYGSVCPGKQLLKVKVNPMSEDCMSVNIFREKGVEEGAKVPVAVYIHGGAFNRGSSMMHNTASMVGWSEKPFIGVSFNYRIGALGFLPSKLTFDEGIVNLGLHDQVFLLQWVQENIAAFGGDPSDVTIFGLSAGAHSIGHHILNYKEGVPALFHKAILESGAPTSRAVHPYNAPVHEDQFALFVEEAGCGKVSPSEITNCLRTQPAEMIIEAQATVFYKYNPSLRWAFQPVIDSELIHQRPIDAWNSGKWNKVPIMTGHTTNEGTYYVPPGLSTPEGFTDFWHTLLPHYTPEDLKTINSLYPDPSKNPKSVYTESRNMTALSIGPQFKRVEAAYAHYAYACPVRQTASIVSSASSKEPPVFLYHWALNQTVKGGANHGDNMWYESFDKAITSISPAQEEVSGLLHAYVTSFITTGNPNTVKGRYENRPDWKAYTKNKAELAMTFGQGNDERAGGSSTGTPAKLVDSTWVKKECAFWWEKSVDTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWP0</accession>
    <name>A0A3D8RWP0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PEBP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_06315</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWP0"/>
    <dbReference type="OrthoDB" id="2506647at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030162">
        <property type="term" value="P:regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046578">
        <property type="term" value="P:regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF141">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017664679" description="PEBP-like protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW78463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="20136" checksum="0C97C78F4AD83440" modified="2019-01-16" version="1">MKAGSISLILALVGVVSAMTPPGLIPSNTENMTVFFNTSSLATNGIAIAQSGAKSTPTLALDKSLTGTTFMVLMVDPDAGNVGGNGSSAFLHWMQDGFTSSSKSVTVGNKTVFALENTANVVPIAAYLPPGPPTGQTHRYTQYLVDTTGVKGFTVSSSVANSTMTRVAFNMQDFVKQANLTIISANFWKTTGGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S289</accession>
    <name>A0A3D8S289_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_05074</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S289"/>
    <dbReference type="OrthoDB" id="78947at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047134">
        <property type="term" value="F:protein-disulfide reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045108">
        <property type="entry name" value="TXNDC17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010357">
        <property type="entry name" value="TXNDC17_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452">
        <property type="entry name" value="42-9-9 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12452:SF0">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06110">
        <property type="entry name" value="TXD17-like_Trx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="6"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW80376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="108" mass="12160" checksum="52AAC117BCCB967D" modified="2019-01-16" version="1">MTQDYTYKIYYSARDEAGVMWCPDCRDVESTLSSTFKLDQAEGAQAEIIYLTRPDWKSPANQYRHAPWNLTGIPTVLKFSPQGAIVAKIEDADILDPAKLAAFLKQEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2G4</accession>
    <name>A0A3D8S2G4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">D-xylose 1-dehydrogenase (NADP(+), D-xylono-1,5-lactone-forming)</fullName>
            <ecNumber evidence="3">1.1.1.179</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">D-xylose-NADP dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_05048</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>D-xylose + NADP(+) = D-xylono-1,5-lactone + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22000"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15867"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.1.1.179"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfo/Idh/MocA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.179" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2G4"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047837">
        <property type="term" value="F:D-xylose 1-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050984">
        <property type="entry name" value="Gfo/Idh/MocA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055170">
        <property type="entry name" value="GFO_IDH_MocA-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604">
        <property type="entry name" value="OXIDOREDUCTASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22604:SF105">
        <property type="entry name" value="TRANS-1,2-DIHYDROBENZENE-1,2-DIOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22725">
        <property type="entry name" value="GFO_IDH_MocA_C3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="6">
        <location>
            <begin position="12"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="GFO/IDH/MocA-like oxidoreductase" evidence="7">
        <location>
            <begin position="157"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00042988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW80350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="360" mass="38951" checksum="AF7AA90B4A96D0BA" modified="2019-01-16" version="1">MGDITNSTPETLRWGIIGCGLISSWFVADIVLPRSSAPTKHIVQAVGSSSKSKAQAFVEKHCPAATPTLYESYSGVYTDPDVDVVYLGTPHALHYQNALDAINAGKNVLCEKPLTINAKQADALIAAARAKNVFFMEAVWTRFYPLVKKLGELLHTEKVIGDISRAFIDFGLDMPISKLPPSARTADPALGAGALLDVGIYTLTWAAVIFDQHPVQKASGQEPLVASSMSLTGGADDITSVILNYPALHAHAICTCSMNCRSGPEFARVEGSLGTISVGGPAASKPEYLIVKKKDGQEEKLEFKFEGWGFFYEQDAIAECLAKGEKECSVMPLDETSRIMRLMDQIRAANGLKYVQDDEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3Z3</accession>
    <name>A0A3D8S3Z3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_05588</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3Z3"/>
    <dbReference type="OrthoDB" id="3598904at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF4">
        <property type="entry name" value="HYPOTHETICAL CONSERVED PROTEIN (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW80890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="341" mass="38793" checksum="BB7D1D7356F201E2" modified="2019-01-16" version="1">MHPTHDMRSTLIASLLFNCFESFHGYHECAIQQVKEGLREIGECFEADGEGVADLLKKLDEQAVLYANTRNAEIHELYRKCGQESIDAMPRQFSTLAEARILLEIIIRRSVHWLASTIQLHDFSETCEPWSLFDVNPPAKEKKKTLYEYERWRQAYEPLLESEKKTKGGESFVLAMTLRLHWLAGYLTVASNASDISLDSGRFAAELEEIVSVSGLLLVEAMKTGKPYNFAFDMQVIVPLTTVGWIYRHRALRRKVITLLQQSPRKEGVWDGVVIAKVLAWLVDLEEEGLADEEYIPINSTARMIRMTFDAKAKVAEVSCLKPVRGAGSEKLIQMEAKIPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SA01</accession>
    <name>A0A3D8SA01_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">HOOK N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_04594</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SA01"/>
    <dbReference type="OrthoDB" id="49395at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030705">
        <property type="term" value="P:cytoskeleton-dependent intracellular transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22211">
        <property type="entry name" value="HkD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043936">
        <property type="entry name" value="HOOK_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947:SF28">
        <property type="entry name" value="GIRDIN, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18947">
        <property type="entry name" value="HOOK PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19047">
        <property type="entry name" value="HOOK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116907">
        <property type="entry name" value="Hook domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HOOK N-terminal" evidence="6">
        <location>
            <begin position="7"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="567"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="241"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="591"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF19047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW83103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="600" mass="68354" checksum="AAC0BEC6096629B8" modified="2019-01-16" version="1">MAGNKEAALIEWVNTFPLDTKVETLLELTDGYVLNQMLGNLDRQYLASNLEKNTAPSKWLSKKQNLEAVYKSLLRYIRNNCEDFGSVTLDNTPNFNAIAENSDIEETIKLLTIMLVAAISGPNQAKYITDIQALSTPSGIAIMQIIQKMQEMDQHASGTETPLEDTEKPSRLTHDAELAAEEERASLLAEHAALKKRYADHITRFEILQDSHQELLSKQEETVSELRSLKASNSGDLADYVEEMRTEIQRRDELIASQEAQIEDNRRTRERQEKELSTLRPAYEKARTLEDVVQELRNENATLSKKANMVDNFQRKLESQSGIEKENTKLREQIDTYQENQKFFDETVQENSKLKASVNEYQKRFHSYEREYLDLSNEKKMLEEGVRRREAEISTLNEQKLHDERFISDLQESLATGGGQPAYPSTPTAQAGSVMTLDKELDESHETTNYALENSRLKAEIQLIKNSEGSSDADLHNKLLDAEARYNDLEQRFNQLTQSVPANGAALKEVSQDISPQRRTLQPRRSLMWHKCCSPKRKAAVTAPGLAKEAEDCRREYCRWTEGIDEERSSRKRNDVNGLVRLNESLAKQPCGSSTPTRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SA89</accession>
    <name>A0A3D8SA89_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">MFS general substrate transporter-52</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_04746</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SA89"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046943">
        <property type="term" value="F:carboxylic acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000013">
        <property type="entry name" value="Related to multidrug resistance proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF84">
        <property type="entry name" value="VACUOLAR MEMBRANE AMINO ACID UPTAKE TRANSPORTER FNX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="215"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="360"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="528"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="64"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW83255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="554" mass="59611" checksum="332B3D55AD8ADE71" modified="2019-01-16" version="1">MALANTENEVSEHSPLLGEQTPTKSSTGAEGIDGSPDAEAGVGEVREMPLFEGNKVMIAKLPYLLPPLVIGILLIAADQTITVTSYGRIGTDLNALNSTSWIATGYYLTMTSFQPLYGKLSDIFGRKACLLFGYAVFGIGCVFCGLARNIEELVFARAFAGIGGGGMTTVVSILLSDIVPLRERGTWQGYLNIVYTIGSSSGAALGGILADTIGWRWSFLGQGPLCFIAFGIVYFVLDLPQQEDTHWREKLRRIDFLGAFTLVIAVFSLLLGLDRGSNVAWSDTITIVACCLSIPLSALFLLVEIKFAANPFAPGHIIFERSLCASYFSNFFQLASYMACLFYVPLYFQAVGGMSATAAGMRFIPLVVMSTAGSLAGGVIMQRTGKYYWLTVISYILQATGIFGVTIACALHADSWWLLLALIFGAVGGGAAITTTLINVIANADAKDQAVATACTYLFRSLGSVVGVSIGGTVIQQVLRKELRSHLKSGHQADQIVERVRQSLDYINELDPRTRALVRICYQKAETVTFALAVAVAIGAIISSLFMREKKLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAD0</accession>
    <name>A0A3D8SAD0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HTH CENPB-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_04820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAD0"/>
    <dbReference type="OrthoDB" id="9909311at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050863">
        <property type="entry name" value="CenT-Element_Derived"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006600">
        <property type="entry name" value="HTH_CenpB_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007889">
        <property type="entry name" value="HTH_Psq"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303:SF70">
        <property type="entry name" value="HTH CENPB-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19303">
        <property type="entry name" value="TRANSPOSON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04218">
        <property type="entry name" value="CENP-B_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03221">
        <property type="entry name" value="HTH_Tnp_Tc5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00674">
        <property type="entry name" value="CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51253">
        <property type="entry name" value="HTH_CENPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH CENPB-type" evidence="4">
        <location>
            <begin position="185"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="269"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="342"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="409"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="292"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="471"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW83329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="568" mass="61146" checksum="C8F29BC55D943DEE" modified="2019-01-16" version="1">MHESMTQIGMDHERHIGPENGYSNEWVEIGNGYSSQHQSPVQEYGGYGFLQPMQQQHGMPIEPSFTMPPPPPAHTTHQQLLPLIMPSHPTWPSMLTNPVNYSAPPVAIPSASNQKPQKLATAHVAPSPRKTLTDNDRRRMCQYHEDNPSVKQTEIGAMFGVERSTVSKVLRQKEKYLFPEDRSLSPVKRAKGKFPDIERALSNWVRNSQKQGIPLTDAAIKEKARFFATTVGNNESHLKTNSTSWLEKFKQKNGIGAGKLMRRASETNISDAGSLNPDSAGGSASQTPNGVSPSSPGGLASPSPLSASKSDEDLRSDGVNGYIDFGHGNGAYRHTNSQSTTSLSSAFTDTAPSSFSGGPTSPTTPFTFSPDGSFMPSQHARLPPPGNNFQRPRSQTFPMLGIDPSFISQHSQASDAMTPKYNGLPSTAPSSALDSPIQEMDQPFGLDSAISPPPLHHSSSNGSMAPPASGASVTGLQSPLSSSAPNSPTQDDARRALDTLLGYFNQAPNGLVDQNEYMTILKLTEKLRLQTGNNSGPLPGGLHCIAEQDNEQQIQTAPKMEASMSSDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAT4</accession>
    <name>A0A3D8SAT4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_04907</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Sterol O-acyltransferase that catalyzes the formation of stery esters.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAT4"/>
    <dbReference type="OrthoDB" id="10039049at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034737">
        <property type="term" value="F:ergosterol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008204">
        <property type="term" value="P:ergosterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF9">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="192"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="220"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="350"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="403"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="534"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="265"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="281"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000439-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW83416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="558" mass="63903" checksum="DD9915A87B68F75F" modified="2019-01-16" version="1">MSSSADVFTNGNGHHDHILRPRAIKPPNPSVVRTLSEDGLLMNSSYMKESGENGGTAQTSGRSTPVPHDAPPSVKTISSARKQLKADQRRRIFPTIEYASRVSHFDPNSEYRDFQGFFVLFWIALTIMAITTMLRNIKDTGYPMRVQIWQLFTVKTWELALGDALMVGSTGLSLPLHRLFRSDLGKSLGLRWATGGMAIQSIYQAIWFAFWVFIPFHRDWTWTAQVFLTLHTLVLLMKMHSYAFYNGHLSETERRLQALDNPNTASKAPAYQYPNPGHKRSSSERENAEKDADELSRLREDLAVELVSPMGSVAYPKTLTWSNYLDFLLCPTLCYELEYPRTAGIVWTELGYKVLAVFGVIFLLTITSEEFILPVLTESASRLETVTSFAEIMLILAESISNLLFPFMITFLLVFLVIFEYVLGAFAEITCFADRHFYSDWWNSTDWLEFSREWNIPVHHFFRRHVYSASRPHIGRPMATLITFLISAIGHEIVMACITKKIRGYGFLAQMSQLPIVMLQRTEWVRGKRLLNNVCFWCSMILGLSMVSFTLYYLLDYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAY4</accession>
    <name>A0A3D8SAY4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_05018</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAY4"/>
    <dbReference type="OrthoDB" id="2118427at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017674753" evidence="1">
        <location>
            <begin position="20"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW83527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="244" mass="24337" checksum="92AE4CD901BAEFFF" modified="2019-01-16" version="1">MKLLYSCFILALLPRLALTHPISVPANAIVVSSEFTPDSVGARGEPFESFDKRAIKAASTKTAAAAKAASTTKAAAAKAASTTKAAAKAASTTKAAAAKAASTTKASAQSVQSAVSGFASDANTVSSSLNSLLTTTDTATIKSLATTAFARESNENSQRAVLAAAAGTTATAANALIVKNTPIVLKGLQAIIDSPTAATAKSNVATIAKARNPNILPSITTLSNAALKAVGLTQNAQTFTATNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SB84</accession>
    <name>A0A3D8SB84_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SB84"/>
    <dbReference type="OrthoDB" id="2924818at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW83421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="406" mass="44897" checksum="422346C4ED73675E" modified="2019-01-16" version="1">MSSPALSSALAPVVKRGRGRPRKVDRPLNAVANKGEKRTKKEKAGVAITPPTSVRRSTRAMRSSEKKIEDEQEEEGQGKKKKWTEPPLAFASPSTRIKEKDEDGVIYEDRAPIKTLPESPTTRMNHEYSGEKFLGCIKASDRKENEAIQTESKALVWDNVRYYPSPPQMCFEKDRAIIGAEAQIVSIPASTSPAYTAINREEKRGFYFAYDEDMDTSFLQSRHPSARLVGAAKLADYKFVINEAGFAAIVSHKGSQVYGILFSVLASALANMEGELVVEGMYEKACLEVEMVELGLNTWGHTRLESDRELAEATGGLGDGEVIRALVCVSSAEVKEPGAIDEELIPYMNRAILEGLAEGFPDVYVEELRKVVPRPVAPWNMGGRKNEKKSRKSAEQNKAEEVAGKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SBI4</accession>
    <name>A0A3D8SBI4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_04955</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="8">Belongs to the xlnR/xlr1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SBI4"/>
    <dbReference type="OrthoDB" id="3837332at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051439">
        <property type="entry name" value="XlnR/Xlr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47663:SF1">
        <property type="entry name" value="XYLANOLYTIC TRANSCRIPTIONAL ACTIVATOR XLNR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0010">Activator</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="10">
        <location>
            <begin position="48"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="79"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="193"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="484"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="663"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="92"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="196"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="245"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="686"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW83464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="869" mass="97247" checksum="6CF0D8CBDFDD4CCD" modified="2019-01-16" version="1">MAWSNGVEADTDSRVGGGDSSVVRIQPDSLSAETRQGNQRNKQRTSRACDHCNAARRKCDGHQPCAYCVRTKSICDYKRRIKKRGKPPGTATKKQNQPLQDNSPSLTEQTSPEATPSQGQSSSHVAAPSTEYGESVSPDFTVSRSAFMTDDYHMFDIDPSWRIEDFDNGLGQDIEVPQPFSTYGIEAQRSMMAEMRSSSGYPDSQNTPPSPHDSTADNEPVVVYGIHSFPSAKDASSARVEPNHKTAQSPPLTFKISRSGTLPRATSIADKLRQRKLSHQMSSVERPIRNGSGLQYPVLRDTIHLLRPFIPDSLSFDLLEAYFRVSPATNAYLAPCAPPTVYRKHSFLRQENPRSSSQVLLVSMLWLSAQTADIPVLNVSIARRKYVRRKLLEMTTKLLRPLNEVSLDTDFLQSHNGSFATPTSDESNARLRQENGSVNALDEIMAYVHLAMVTSASEFKGASLRWWNLAFSLAREARLYQEFPDSQAESTHESDHHTPVPESPKQRPHNYPPEYTFGEPSAFPSSKVSEETREERRRVWWFLYTMDRHISLCYNKPFALLDSECQNLHRPCDDELWLSERDIVPASMSHVGQGPSYECSAPTFFGFFMPLAALLGEIVYFVQAQNHPRFGISQSTLLDWKQWEKGISDRLYAYQQSLESLLQPDETGTPRGPPCAGVELPAVHSPSGTTQSSPHETAIPIRNRVIYAYAKCIIHVLHILLAGHWDALTLLEKASWASSSAFVTAIGHVVEAASCLEMLLDVDPDAHFMPFYLGVYLLQGSLPLFVAADQLKTDAADLIIQACKTMIRVHEAHIIRMPSEYQILFVSALRLALNEMQGRTAYITESSVAKQMHVFQRYSWTREGRGLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SGX2</accession>
    <name>A0A3D8SGX2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="4">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BP5796_03924</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SGX2"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008349">
        <property type="term" value="F:MAP kinase kinase kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071470">
        <property type="term" value="P:cellular response to osmotic stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019236">
        <property type="term" value="P:response to pheromone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001402">
        <property type="term" value="P:signal transduction involved in filamentous growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01093">
        <property type="entry name" value="CRIB_PAK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06614">
        <property type="entry name" value="STKc_PAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000011">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000385">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.810.10:FF:000007">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.810.10">
        <property type="entry name" value="CRIB domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036936">
        <property type="entry name" value="CRIB_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051931">
        <property type="entry name" value="PAK3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033923">
        <property type="entry name" value="PAK_BD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45832:SF22">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE SAMKA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00786">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00285">
        <property type="entry name" value="PBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0589">Pheromone response</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CRIB" evidence="18">
        <location>
            <begin position="248"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="566"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="147"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="330"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="78"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="117"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="330"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="16">
        <location>
            <begin position="399"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="471"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="489"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="595"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RDW85599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="846" mass="92578" checksum="1945541B89BA693D" modified="2019-01-16" version="1">MDAVSRSIKTKRRLTKKPPPDRAAAIANQASVDGSSGRRGSTDSKSVRSQRSSTSLQRAPSAPYPRSQPYGHTRNTTSPNPAAYASSNSSVDRQIPGGPSPILAGSEFTLPAGQPGGNQYSSQSRRLSQKTSAELIGAPFDGSGILNQFDSSKASGYQNSLRRPPPPALSHTSPGRITSPPLRQSASFSAGDKMSEKLAPRVSENQLISPKRYSDESKEPKSGMLRKKSGFSGFMNSIGVGSPRNVKISAPENPVHVTHVGYDNQTGQFTGLPKEWQRMINDSGITKKEQEQHPQTIVDIVGFYKENTEKGNDEVWDKFDHAKVPELRIGTTNQGPLSPLLNTPNYQNMGTPMMSPPASPRFPRNAEASFENPRSPPPVPPGVGLAIHSKDPNGLVPSRPAPRPPVPGPTRSAPPPPLAAKDSGIGMPRQSDDLPALAYVPPSQPMLPEEHRSRSNSRVNGSSPYQATSPQATYQAQLSQQQERAMYEVQQQQLARSQSTKQKGQTPPAQPGQFPRPEANGIPHPSQQARAAPGPRPRQRPRQSTSFDVVARLNQICTAGDPRDIYRNLNKIGQGASGGVFTGYESGTNRLVAIKQMNLEQQPKKDLIINEILVMKDSSHPNIVNFIDSFLITGELWVIMEYMEGGSLTDVVTFNIMSEGQIAAVCRETLKGLQHLHSKGVIHRDIKSDNILLSMDGNIKLTDFGFCAQINEAHNKRTTMVGTPYWMAPEVVTRKEYGRKVDIWSLGIMAIEMIEGEPPYLTESPLRALYLIATNGTPVIKDEHQLSHLFKDFLYFALKVDPEKRASAHDLLRHDFMKQCADLMELSPLVRAARKARAQEKAQKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHT8</accession>
    <name>A0A3D8SHT8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphate transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_04240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Sodium-phosphate symporter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHT8"/>
    <dbReference type="OrthoDB" id="260807at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035435">
        <property type="term" value="P:phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001204">
        <property type="entry name" value="Phos_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11101:SF57">
        <property type="entry name" value="PHOSPHATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01384">
        <property type="entry name" value="PHO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 7" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="491"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="574"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW85915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="606" mass="64518" checksum="E375975E9A50D454" modified="2019-01-16" version="1">MALHEYTYVFVIGTFFAMLDAYNNGANDVANSWATSVSSRSITYRQAMIFGTIFEMLGAITVGARTADTIKNGIIPNSAFRGDAGVQMLAFTCALAAASSWVMWCTKHSAHVSSTYSLISAVAGVGVATVGASNVQWGWNNGKGLGAIFAGLGMAPVISAGFAATIFMLIKLTVHMRKNPVPWAVYTSPFFFLIAGTICTLSIVYKGSPNLKLNKKPGWYVAAVTMGTGGGVAVLAALFFVPYVHAKIIKKDPTIKWWMFIQGPLLFKRPAPAVADRAIVPNYAVVQDEEEEHTSAHSGASVSEDEAHATKDGIEPIMTSSEGSEKQAARTEAAQPTYKELMAQGDEKLHAKLLTKRGPLGWAMRTLRDNPMGPGALYELHNMKMAAIRLPAMVVVGALYGINYDIHAAQTGIAGTPEGKRMQRVYANAEKYPNEVEHTYSFVQVLTACTASFAHGANDIGNSVGPWAVIYSAWSTGNAAAAKAPVPVWQLAVLSAMISIGLITYGYNIMKVMGNKITYHSPSRGSSMEMGAAITVLVFSQFSLPVSTSMCITGATVGVGLCNGTLKAVNFQRVGLLLLSWIATIPIAGTLGGVLMGILLNTPHFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMC6</accession>
    <name>A0A3D8SMC6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RTA1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_03028</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SMC6"/>
    <dbReference type="OrthoDB" id="4521223at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF9">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW87334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="35654" checksum="ED175CB0B4BADFD5" modified="2019-01-16" version="1">MSARNFTAGTVPGVAANITSITQCTPALCSLEYATVLYVPTLAGNTLYLAIFALLLVIQAVQCVFFRTYSYTIAMICGLVLEIVGYLGRVQMHFDVFAGNPFLLYIICLTIAPVFFTAALYLTLSRVITHYGTQYSRLQPKTYTLTFITSDVIALILQAVGGALADTAATNAASLLGVHIMIAGLAFQVVSLLVFALLAGEFFGKVYGDRARRASRTDSKPSLRVLGLAFAAATLFILIRSCFRVAELAHGFKGKLANEQVTFMVLEGAMITLATILMTACHPGIWLKSVWSAQVWKFRGGKMPEAEKRPALREGEWTAIEGGGSMEMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMY6</accession>
    <name>A0A3D8SMY6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Uracil-DNA glycosylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_03371</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SMY6"/>
    <dbReference type="OrthoDB" id="565731at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008263">
        <property type="term" value="F:pyrimidine-specific mismatch base pair DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10028">
        <property type="entry name" value="UDG-F2_TDG_MUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.470.10:FF:000010">
        <property type="entry name" value="G/U mismatch-specific DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015637">
        <property type="entry name" value="MUG/TDG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159">
        <property type="entry name" value="G/T AND G/U MISMATCH-SPECIFIC DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12159:SF9">
        <property type="entry name" value="G_T MISMATCH-SPECIFIC THYMINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="5">
        <location>
            <begin position="100"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="43"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="282"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="66"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="285"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW87677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="301" mass="33154" checksum="E9929555118A3959" modified="2019-01-16" version="1">MSLPAEDDSSDATATSTTMAPASFAGRLDLANFAFSPKLAISSTNPTRNLRRTTSASRPQPKRRSSNSLEPSHSPSPSKKRRSLSGYAPPSKYAHLPLLPDVIAPQLLVLFIGLNPGLQTSIQGHAYAHPSNLFWKLLHSSGCTDRRLHHSEDASLPVLYSMGYTNIVARPTRNGAELSKAEMDASVVALEEKIQKFRPEAVAVVGKSIWESIWRVRYGRPIKKEEFKYGWQDDKERMGTSDDWEGARVFAATSTSGLAANPLPAEKERIWRDLGTWVEQRRAEQSSGASVNSAQDLSHEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SN64</accession>
    <name>A0A3D8SN64_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03426</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SN64"/>
    <dbReference type="OrthoDB" id="3505331at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="12"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW87732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="218" mass="25145" checksum="5E133D04313A82C9" modified="2019-01-16" version="1">MPLRNNLCLSKFTVFPLLPKEIRLRIWDFALVPRVIPIARREDACRGDGIQFQILSSASHNPFVIWIALACAESFRVVNMRYYEWSIWDFFRDVTNSLISPLHDVIYLPYDLRGSTVQQLHQDFTAQTAFLRAIALSSTSTHGIGKPTELLEALHNFPRLEELVIVKTNAGKDWGDENKVWQIPQDILNAMEILKKEKWPDWEIPLIRVVTAEGDVLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SQ86</accession>
    <name>A0A3D8SQ86_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_03652</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SQ86"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF562">
        <property type="entry name" value="ALDEHYDE REDUCTASE II (AFU_ORTHOLOGUE AFUA_1G11360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="3">
        <location>
            <begin position="15"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW87958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="347" mass="38790" checksum="A6FB233B81D19156" modified="2019-01-16" version="1">MSDPKTAIPKGSWVLVTGATGFVASHTIKLFLERGFKVRGTVRDVRSAAWLTEDIFKSFADRGDLELAHVPDLGAKHAFDEAIKGVSAIAHIASILSFSDNPNEVIKPVADCVKWILEAASNEPSVKSFVYTSSIAAAVDLTPGVTVHAGPDAWNDKAVELAWAPPPHPPDYWHWVYQASKVEAEKSVWAFVEKNKPHFAVNVISPATIIGEALTKKHVESPYPWIKNLYDGKEEIRALFQAIIHVDVKDVALLHVAVVLDTECDGARLQAWAEYCNMNDILDILRRLRPQKRFMDNFPNQTMLTITADYDQQLALLKKWGGKDEWTSLEQTVADELKSITKWYPEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXU9</accession>
    <name>A0A3D8SXU9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Capsule polysaccharide biosynthesis protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_02269</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the lcsJ thioesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SXU9"/>
    <dbReference type="OrthoDB" id="265761at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00586">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051490">
        <property type="entry name" value="THEM6_lcsJ_thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12475:SF4">
        <property type="entry name" value="PROTEIN THEM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13279">
        <property type="entry name" value="4HBT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="314"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW91104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="382" mass="42153" checksum="18B0F1A8F408BE72" modified="2019-01-16" version="1">MASATQLPLKSITFTTALLVAAGLSRVNIHKLLVSTFTGPGSYSRIAVLAVVLANLKNVPYAWHFRVWNGILKHCLFSIPRYPRSTPKPSTLFLPIITTSHSPVAECDYNLHKSNSTYFADLDVSRSHLVCCLFQPGIDALQHNPARQLVTDAAGKPVKGRWGIMLGAVHCSFKREIKPYEPYEMWSRMLCYDRKWIYIVTHFVKAGTVRPSAYILGDGSWFGGKNALKRGAKVRGEADDELDQKAIFASALSKYVVKLGRLTIHPEVMMEASGMLPPRPSGWANMRGEVAAAGAAAPASVEDSYIEFEFLSRENGNGSGSESASSDEGKHGAEEEWDWKRTVAMNEKGLKLAEHFAALDALQDEFTGSKEPALGRYRDFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYJ7</accession>
    <name>A0A3D8SYJ7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">[acyl-carrier-protein] S-malonyltransferase</fullName>
            <ecNumber evidence="1">2.3.1.39</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_02515</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.39" evidence="1"/>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYJ7"/>
    <dbReference type="OrthoDB" id="541883at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.250:FF:000006">
        <property type="entry name" value="Malonyl CoA-acyl carrier protein transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.250">
        <property type="entry name" value="Malonyl-CoA ACP transacylase, ACP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050858">
        <property type="entry name" value="Mal-CoA-ACP_Trans/PKS_FabD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42681">
        <property type="entry name" value="MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42681:SF1">
        <property type="entry name" value="MALONYL-COA-ACYL CARRIER PROTEIN TRANSACYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="5">
        <location>
            <begin position="58"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW91350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="422" mass="46819" checksum="CE47467170990F45" modified="2019-01-16" version="1">MKRITSSAGKQCFESRMLNKLAFRYPFSQESSRASLCNAQRQVRHSSTQPARPRTAMFFPGQGVQKVGMLTPWLEAFPATAGPIVEEIDHLLGYKLSTIIEKGPNSLLTATENAQPAIMATSILILRILEREFGFKLLERVDVTLGHSLGEFAALVAAGCLTFEDSLYLVRKRAEVMADCSRRAMAEHGGEYGMIALVTEPDHLFPLIDAIHEFLGHHSAGSKSESAEDVPPIQQVLIANINSKNQIVLSGNIERIKTLLTHVRQFGGHDPRAVRLNSDSPFHSPLMQPAAIAMKKMLEGKSRVKDRADQDMVSFPGTMECLSNVSARPFQNKEELKDLLARQCVETVKWWDSIRYLDQEEHVRRWIGIGPGKVGRNLVGKEVGMRGKDTVKGGGVWGISHPKEVEEVLRALDETELAAESQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYL0</accession>
    <name>A0A3D8SYL0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_02514</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYL0"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF80">
        <property type="entry name" value="DIENELACTONE HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="2">
        <location>
            <begin position="89"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW91349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="350" mass="37685" checksum="7F50941E5ECEC491" modified="2019-01-16" version="1">MAEPEVATKAPESDVMEDVDTGTPIEPKPEALAATPEEPAGAGQGSLFPGDTPAQTGPALGEHCVKDRPTPFGQGPTGEMSQLGGVDVYISKPNDYPHTSSKLLLFLTGATGLHSENNQIQADRYASEGFLVVLPDMFSNDPLPGTPTYAEEKDVSLLDQIKMKFAETSKSFLIDMWLARQTPEKVLPIIHKVMDAAKDEFADAVASGGGIYGAGYCFGGRMILLLAGEKPDTVTWGQQQPATDEEAGIVKKGPYLKAGAIAHATLVTKDDFEGTKAPLSFVCVENDQLFPDDVKEYGDKYLKENNIENEFKVYPNVPHGFGVVGEYEEASIKVAQGQAFDQMLGWLKSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYN3</accession>
    <name>A0A3D8SYN3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_02555</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYN3"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000374">
        <property type="entry name" value="3-oxoacyl-(Acyl-carrier-protein) reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF111">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_1G10100)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="29"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW91390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="303" mass="32313" checksum="B12A29FAFC66A8DC" modified="2019-01-16" version="1">MGDSARPPHTRMASTNLGAAQSYRPLEGKLAIVTGASRGIGAAIAQNLASKGASLVLNYTSDTSEKATQELSESLSSEYGVPTFVVQADMGSPAGPEHLIATTKNHFSHPKTGKFQIDILINNAGVSKNQSIEETTIENYEWTYRINVLGPLLLVKAATQYLPTDRSGRIVNISSVSSSEGFIGQSIYGGSKAALEAMTRTWSRELAERATVNSINPGPVKTDMWNGTTEQFKENMKPWIKKTPSSAIRDLDDEDLKAGAEAAGGRPAYTHEIAGIVGMLCTGDSVWCTGQVVCANGGMRMVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZ57</accession>
    <name>A0A3D8SZ57_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glycosyltransferase family 32 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_02760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZ57"/>
    <dbReference type="OrthoDB" id="409543at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF1">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="343"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="343"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="407"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="481"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="525"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW91595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="538" mass="61899" checksum="6D1EDF94DB095F4E" modified="2019-01-16" version="1">MFRRHPRHQPLWIAVILFSCSILLMTFYKRDELSCMRISHIEDDTRPQDPITNNGTVEEEAKIPRHIYQTWKNIAVPNTAHVNSWQQKNPDHEYTLLTDHTADNFLQRYYAHRSDILEIYHGLRQRILAADMLRYLIIYALGGVYTDIDTSCSRPINEWLLNERAQKDFNLVVGVEADVDWDPATLELAGFVDNIQFIQWTVMGKAGHDALNRTIEGIVTKVHNDAWARNSSISQLEHDQNGILATTGPWMYSRAVRSHIDQTLNRTVPNAEFHGLTEPKIFGDVLVLPVNAWAPDPPHSNSGSKRTSLLRHWKAGSWRTEFVAAQARKEQKVAMKIEADESKRLSEKQMEQIRLNRVEGPGEHAEERRKKEDERRVQLEKGRHRKQTLMMDRLRASKNSTVASESNNRDGTKTPEPKEASQQSDEHPQEKILQQDHDPAQQPQQLQQEPTIESGQQPEKPMIGDQRQEEKLWSPAEGLQEQEHKPVPAHKEEKSGEKQDEESTRSEEQQGQETKPVPANEGAKQRTTTELSQEGLQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZG3</accession>
    <name>A0A3D8SZG3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isochorismatase hydrolase-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_02849</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZG3"/>
    <dbReference type="OrthoDB" id="1739143at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF1">
        <property type="entry name" value="ISOCHORISMATASE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="29"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW91684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="221" mass="24019" checksum="DA245339DDB7312C" modified="2019-01-16" version="1">MTMIEIPHQQPSYKRPENINRLGWGARPALLLIDVCRAYWSEGSALDLLSNPEAAAAPDSMRRLVAAARAGKVPVIWAQVRYNAGVMLDAGMQYQKSTVCSIWQDGDTRGMDAWLPGLTADANDTIIYKKNPSAFFATTLSTELQLMHVDTLVLCGVSTSGCVRATALDAMCHGFRPMVVGSACGDRSKEIQNATLYDLDSNYADVVSEAEALEKVISGWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZS8</accession>
    <name>A0A3D8SZS8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_01200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZS8"/>
    <dbReference type="OrthoDB" id="4216928at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="8"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW91806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="377" mass="42212" checksum="FEE4031A4D86C151" modified="2019-01-16" version="1">MPTSLRRACYGCISAKRRCDPQLPKCPRCRKNGLACTYENQPLSHVQPTDEEKLEPLPEVPAQPGFLVFSDIVSAERAARKFFDMQSVDPHLSIPEIRVVPDPGVVYSVIAQIANIPKAIAQGQTSPLVHSQLHQRLPEDSVRLEHVLLLQKAFVGNTSSEIKSPSRNMHLQRLMKTSVLDLPLVDILIRVHELVLYIIVYSCNNFPSPYMSEIRPCLDILLRWIEHLWTVAQQPPTNSDGPWQNWVVAESTRRSIIACAMVRGAVTVASCGYCVYQPFLEALPFDNRNELWEAMSEDAWKSAVARHGGEPEVLVSFHEFIQGYEEISGIMNEGLFQRLLLIMYHGSEALDALGSCRAIAPPRTNVLAAAVTCRHGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T147</accession>
    <name>A0A3D8T147_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF3533 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_02893</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T147"/>
    <dbReference type="OrthoDB" id="2140105at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022703">
        <property type="entry name" value="DUF3533"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053001">
        <property type="entry name" value="MNNG_permease-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814:SF2">
        <property type="entry name" value="DUF3533 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34814">
        <property type="entry name" value="NITROSOGUANIDINE RESISTANCE PROTEIN SNG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12051">
        <property type="entry name" value="DUF3533"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="273"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="333"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3533" evidence="3">
        <location>
            <begin position="36"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="460"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW91728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="505" mass="57302" checksum="C163BE6492DE5B20" modified="2019-01-16" version="1">MAFERWYPKAHQGRVSGRDAAVRNPRHRFLKEAGINLILLQILFLGLFCYIFGALFQQSIHTHNFQLVYVDYDGGIIGSSLWAAYQKMKGDTFPSIMQATTVDYPSPQDLRKAVCSTRFWSAIYTSPGASLRLELALAGGAAATNYNRSDVITYIWNEARYSPIQDTAISGSLKTLASAARLEYTATNGTGAMKVLSSTNPSAISVFANPWELVDTDIQTTIQGSRLIYNTLVVILILIQEFFYLGTINGLYIQCKIYQRLYPHRIIIYRNMISLAYTCCGSLCTTGAIWAFRAGWNVNGNQFALTWLVLWLFAHSNFLWLDVFTVWLPPKYVPMSLITWVVFNVTSILVPFELSPGFYRWAYAMPAHEVYQALTDIWSRGCNPQLHYALPILFSLELLGLFLGALGVYHRCHYATLAEEQQEKALSERVNIGMAFEEKHKKRGDVSEDQRTGVENMGDLETIMSEREELGEEIQKEDSKIQENQRQTNRMINFGPSFNLAYESV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1D5</accession>
    <name>A0A3D8T1D5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Class II aldolase and adducin-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_01212</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1D5"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF41">
        <property type="entry name" value="CLASS II ALDOLASE_ADDUCIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G01330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="1">
        <location>
            <begin position="57"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="294" mass="32103" checksum="B766BFCFD7163D7C" modified="2019-01-16" version="1">MAPPSATGNDREIVDGVLTHEPGISEEEQISVIANGEDHPGAPVFTDKYQEREYKKGRLALAFRIFAKHGFDEGVAGHITLRDPVDPSSFWVNPFGLAWPLIKASDLIRVNHEGKVVDGGPCRLLNSAAYMIHHAIHVARPEINCVAHSHSIYGRAFCTLGRPLETITQDSCAFHNDLALYTSFRGVVLAADEGIAIAKELGRKKAALLQNHGLLTCGKSIEACVFWFISLEKCCHVQLMADAAAGGRGHETVKIDEADALHTYKAVGLEKAGFFSAKPAFDMMEHEAGVDYKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1I1</accession>
    <name>A0A3D8T1I1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative glucose transporter rco-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_01810</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1I1"/>
    <dbReference type="OrthoDB" id="5141738at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010255">
        <property type="term" value="P:glucose mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17356">
        <property type="entry name" value="MFS_HXT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000115">
        <property type="entry name" value="High-affinity glucose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF17">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="123"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="341"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="382"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="418"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="12">
        <location>
            <begin position="21"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="11">
        <location>
            <begin position="56"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="519"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW92416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="542" mass="58923" checksum="403FCB7680098BB3" modified="2019-01-16" version="1">MGLALKKPQGVPGKSWPAIVIGLFVAFGGVLFGYDTGTISGILAMDYWQNQFSTGYVNPQGHLDVSPSQSSEIVSILSAGTFFGALAAAPLGDFIGRRFGLIASTGVFTFGVILQTASTAIAMFVAGRFFAGFGVGLISALIPLYQSETSPKWIRGVIVGSYQLAITIGLLLAAIVNNSTHNRQDSGSYRIPIAVQFAWAIVLVTGMLILPETPRYLIKQGKPERAAKSLSKLRRLPADHNAIIDELSEIQANHEYELTLGKASYLDCFRGNMLKRQLTGCGLQALQQLTGINFIFYYGTQYFKNSGITNAFIISMITSSVNTASTFPGLYAIDKWGRRPLLFWGAIGMTVSQLLVAVLGTTTTGQTADGTVFAKNVAAQKASIAFVCIYIFFFASTWGPIAWVVTGEIFPLKVRAKALSMTTATNWLLNWAIAYSTPYLVNFGPGNANLQSKIFFIWFGCCFLCIAFVYFMIYETKGLTLEQVDELYAEVSVARNSVGWKPTTTFRDIRASVAQQGGLAPTGKVDEKTGEHMAEYRSEHDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1P2</accession>
    <name>A0A3D8T1P2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative 2-methylcitrate dehydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_01891</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PrpD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1P2"/>
    <dbReference type="OrthoDB" id="10055203at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047547">
        <property type="term" value="F:2-methylcitrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019679">
        <property type="term" value="P:propionate metabolic process, methylcitrate cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4100.10:FF:000001">
        <property type="entry name" value="2-methylcitrate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.120:FF:000001">
        <property type="entry name" value="2-methylcitrate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4100.10">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.120">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012705">
        <property type="entry name" value="2Me_IsoCit_deHydtase_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036148">
        <property type="entry name" value="MmgE/PrpD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042183">
        <property type="entry name" value="MmgE/PrpD_sf_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042188">
        <property type="entry name" value="MmgE/PrpD_sf_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005656">
        <property type="entry name" value="MmgE_PrpD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045337">
        <property type="entry name" value="MmgE_PrpD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045336">
        <property type="entry name" value="MmgE_PrpD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006943">
        <property type="entry name" value="PRK09425.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02330">
        <property type="entry name" value="prpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16943:SF16">
        <property type="entry name" value="2-METHYLCITRATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19305">
        <property type="entry name" value="MmgE_PrpD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03972">
        <property type="entry name" value="MmgE_PrpD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103378">
        <property type="entry name" value="2-methylcitrate dehydratase PrpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MmgE/PrpD N-terminal" evidence="4">
        <location>
            <begin position="78"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="MmgE/PrpD C-terminal" evidence="5">
        <location>
            <begin position="351"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW92497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="556" mass="61320" checksum="0DBE1CAF86E5BF17" modified="2019-01-16" version="1">MSSLHRGVRTAAKTLRVPALQCRIAASAPLAFNNSRTKSASTAPRHFQSYKQFSTMSPLQSGAPPPPQAREYDPEIKDIASYVHNTPIESDLAFDTARFVFLDTLGCGLEGLRFKECTKLLGPIVPGTIVPNGTKVPGTDFQLDPVNGAFNIGAMIRWLDYNDCWLAAEWGHPSDNLGAILAVADWISRTNRAGGNLGNGKVITIKEVLEAMIKAHEIQGCLALLNSYNKVGLDHVVLVKVASAAVVSKMLGLSEKQTADAVSQAWVDGQSLRTYRHSPNTMSRKSWAAGDACQRAVNLVLKVAKGEPGVPTVLSAPVWGFYDVLFKGKPFEFQRPYGSYVMENVLFKVSYPAEFHSQTAIECAKGVHQQLKEMGKSAEDIKEITCRTHEACIRIIDKQFKPMDNFADRDHCIQYMAAVMLVYGRLEATDYTDGGEAATSPLVESLRQKITCVEDPQMTLDYHNPELRTIPNALTVTLNDGTVLEEIHVAAPLGHKQRREEAKPEILAKYKRHLGPHYPEAKVKELVDLGNDPSKLMSMSVDEYVDLYVSKDSKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1T0</accession>
    <name>A0A3D8T1T0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PLP-dependent transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_01884</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1T0"/>
    <dbReference type="OrthoDB" id="5419315at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005685">
        <property type="entry name" value="PRK07483.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094">
        <property type="entry name" value="AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43094:SF1">
        <property type="entry name" value="AMINOTRANSFERASE CLASS-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW92490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="469" mass="50553" checksum="09B0441A7398C030" modified="2019-01-16" version="1">MSLDAFFQDSHIFHRSFSKKPLHVASANGLTLTLDSGKQLLDATGGPAVACLGHNQPEVAQAITTQLQKVGYLFSGGGYSESSTEELAAFILKNKPGGLSKAIFLNSGSEATDTTIKLITQFWHAKGEPQRCNFIARKQSYHGNTLGGLAISGHQSRRQMYSHFMPSNVSFVDPCYAYRCKLAGETDADYVERLKQQLDNEFQALGPNTVAAFFAETIAGSTLACVPAVPGYFQAVREICDKYGALLVLDEVMCGMGRSGTVHAWEQEGIRGPDIQTIAKSLGGGFVPISAVLVHQHIFDVVANVSGSLAGGHTFQAHPVACASALAVQKIIARDNLISNVREKGVLLADLLEKEIAPLPLVGNIRGRGLFWAVEFMLDRENMIPFPMDDDFSSKVKDAGLEVGVNVLSNMGFAGMHKIDTAAITPPFIVTEEEIVKIVELLKVAIEKVSEPYLAARTIVSAEKVQAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1X0</accession>
    <name>A0A3D8T1X0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycoside hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_01815</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1X0"/>
    <dbReference type="OrthoDB" id="5287295at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="258"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW92421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="454" mass="49795" checksum="ADC03D2BC3D8D54F" modified="2019-01-16" version="1">MGGLPQAAVTVSVVVLIYSFICLVLTVLLTFLLWTYGERWTYVALLTIFTSISTLGSFVQQLHYVSDFTVIKEAQFQKALASLDTPALGFGGSAEIGDVVLYWIQFYCYNVMSLMVLFWTVALFSASWGLKTDWLGVWRLYIGPGSKAFGILFPTIVVGLGNCKAVIENPALAFISQTILMFFSLTAGGVLLVMILFKYIKTRRLTMKHSYRSPWWASHNSKSVSSSTGMDASETNATFGTTESEAISARQSTYDRALVTRFTIGFVILAVFEVAIIMFTLVQSDSSASIAAAGHPNFTASGAIVDICLFIPGASASLVVFLVFGTTKSWRQYWTMIVGGCGARSKLQNRSLVRRTRYATEQSVRMDTFERLPSITNEGRSTSKGTVPINLGLDFDFEGTRVQDTTTIELSDSSDDEVLRLPIQSPGGSVKQPQHQTKTSTVSYTSRIPSNSPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T6W6</accession>
    <name>A0A3D8T6W6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Multiple myeloma tumor-associated protein 2-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_00042</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T6W6"/>
    <dbReference type="OrthoDB" id="5390672at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019315">
        <property type="entry name" value="MMTA2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039207">
        <property type="entry name" value="MMTAG2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14580:SF0">
        <property type="entry name" value="MULTIPLE MYELOMA TUMOR-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14580">
        <property type="entry name" value="MULTIPLE MYELOMA TUMOR-ASSOCIATED PROTEIN 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10159">
        <property type="entry name" value="MMtag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Multiple myeloma tumor-associated protein 2-like N-terminal" evidence="2">
        <location>
            <begin position="11"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW94279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="274" mass="29626" checksum="15335C46C7D0D004" modified="2019-01-16" version="1">MDLLSSIRKSGSRGGVNFSWDDVQTSQHRENYLGHSLMAPVGRWQKGRDLSWYAKADDESNSNETAEERRARERKEEIRRIKEAEEDALARALGLPVPERNGAGTGANNIDVGEMRRVIKETGAGDDEIDEVGKAKGFGDFRNQLSNQRRVVYCGDLKEMIEDPEDTEKGAEMAGAEAEVGRGSIEDSGIGQEAGTDIGIGEGMVNGLRGGNEVVLLIGKKGGTGAVATTDIGRDGTINCLEETGIEDHIAANHRMLDVQTEAMPGVDICFLGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T785</accession>
    <name>A0A3D8T785_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">QDE2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_00178</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T785"/>
    <dbReference type="OrthoDB" id="10252740at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02846">
        <property type="entry name" value="PAZ_argonaute_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04657">
        <property type="entry name" value="Piwi_ago-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.10">
        <property type="entry name" value="paz domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014811">
        <property type="entry name" value="ArgoL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032472">
        <property type="entry name" value="ArgoL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032474">
        <property type="entry name" value="Argonaute_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003100">
        <property type="entry name" value="PAZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003165">
        <property type="entry name" value="Piwi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045246">
        <property type="entry name" value="Piwi_ago-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22891">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08699">
        <property type="entry name" value="ArgoL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16488">
        <property type="entry name" value="ArgoL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16486">
        <property type="entry name" value="ArgoN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02170">
        <property type="entry name" value="PAZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02171">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01163">
        <property type="entry name" value="DUF1785"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00950">
        <property type="entry name" value="Piwi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50822">
        <property type="entry name" value="PIWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Piwi" evidence="2">
        <location>
            <begin position="663"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW94415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1022" mass="111556" checksum="6C0DE42F75703274" modified="2019-01-16" version="1">MSFSGFDNRGRGRGRGGPRGGEGGGRGGGGRGGGGDRGGGGGDRGFRGGRGGGGRGGRGGFAAPIQVFSDPNSIITPDANITKIEDDYMTSTAGIGALKLTASFPPRPGHGTLGQKLTVFTNYFELKSVQDLNLTRYNVEVSPQATGKKLKRVFELLLENPEFDGVASEFKSLIISRHPLNISDPYVTEIRYLPEGQDEPKTNAQVYRVRVVTPTTLAVSDMVNYLRATSNTSPVFAQKHEVIQGLNALMGHSANIRPNITSIGQNRHFTILPRDPSNSHPLGGGLESLRGFVQSVRAATGRMLINVNVSHGIFLQPGLLSNLYPQLGFGARHKLETKIKRIRVALTHLPGSKDKKTNLVIPRVKTIFGLASVNDGSGSPNPPRVSSFAAGPKDVKFWLSDVPLSAPKGTKPPTKKKQPSTTNLPNNAYVSVYDYFKHKYPKIVLNERNPVVNVGNRENPSYLPAEVCKVLEGQTIKRRLSPEQTKNLINFAVRLPAANAKSITTDGKVTLGHGDPNLSRFGVSVSAGLVTVPARQLPAPGVRYKNLAGKDFIVEPRDGSWNMRDIKFHTGSSIDPWTYLHIRSNRSGHRDIFDDQDLLSYTVKEFVKFLNRSGIKAAPPIRGPSGYFPALTMVDGDDYANDRQVRHLFTAMSQASAAARPKFVLVILPYNETAIYNSIKTAADTGSGIHTICVVGSKFGKEQGQPQYFGNISLKFNLKAGGINQTVDPKKLGIISEGKTMVVGIDVTHPSPGSKDDAPSVAAIVASVNHTLGQWPSDFKSQEGRKEMVAALEMMFLGRLTMWQKHNKNLPENILIYRDGVSEGQYQILLDTELPLIRRACAQKYPANQTKAGFPKISIVVCGKRHNTRFYPTTEQNADKNSNCRNGTVVDRGITEVRAWDFFLQAHTSLKGTARPCHYYVVLDEIFAGRSVKPPHKNNADALEDLTHNMCYLFGRATKGVSLCPPAYYADVLCTRTRCYMSEYFDPVESSSAPSVSSTGTSQVSMHNIQVHEAIKDSMYYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7H5</accession>
    <name>A0A3D8T7H5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_00253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7H5"/>
    <dbReference type="OrthoDB" id="3439035at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="993"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="515"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1041"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW94490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1041" mass="116047" checksum="019826194676C723" modified="2019-01-16" version="1">MAHSGRDTVNSREQPYSNRSTSTGGRSDKPLFEPRERTRKYFTGANTNATKAGEQDEQRLSTLQRSGSSGNWMNGRTTRRLGLEEAFHKTDENASVQRRQSQTVAGRGSARAENPAARRASYSPGMTPTPPRTLTAAFKMADSEERSASVPIESQRLQRRALDGSPSPAARVRPSSRGSDEKRFQQLKNSEPLDLGRGRGSPLSRRASVVEDDNNTVASSEGSFSGLSLVEDPTDDDFDEKMKQYARDQARVDSLSRMRTGPFSRADVAKATGSPNRTVKGSSTTSLEHSEPPTKPPRTWGSKAKKLPGFLSKVLSPDSSVELKDQEQAQNASLAASSLAADVPIPSVEHESIQPTPPSSRPASAQPNFTSPEKSAPWQADLDFTAQSIMMSPQLRLRSSSKIDQIRDREIQDLAKSAIASRALEEIRERNSAERSRSNSPEIVRKPSIDKMANSPAAKQRKSNSAAPDFVHEPGYAHEKTILEEEGEAIPGTPITVFTGSSINANNNINNQKTSSDRNSERRSSEYKRDQSRDVLRRLSRAASKSPSPLSSENTVDQKPEASSEPAEERPLKPKPQSTLRLEQLSEDSAKRLSSGSVDPEERIAAEAKLFDLDNKSERDSTRGPSPAVSDDEAKVDVTPRPKVDPMSLPTPKVTGAFIDTPAPTARELRRQARDLSPTVKAEEKDAVDKKPVARESRLDKKDSELSHRERQPYRNREKRSQSQPEKQKERPPLINTAKPHRVSEDLRRIKLESQVDDSTLDDFDAILAADFKITDEANDTTIFDAMLDLEHDDKGRLLSDREKQRRLETLALERMSKSLKRTSVSIRDAKRGIEGLEDQVTSITTETPITTHSHTHCSTCATSSPTYHLSIPVPRLWYRHPSSSRRKMTWLGLIITMLLSWYISESIMCDLYCHPTVSSVNTWSPWDPFFPYAIPSKLDHWTGRKVSGAAYEVYRVWTDGKEGRPRWAGPAPRPLNLEPVHPIRYDSMVEARRTATQGSPKAESKEQKSNFWGWDSSARSQKSQVDDSEESSMFEDEMIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7N1</accession>
    <name>A0A3D8T7N1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Survival protein SurE-like phosphatase/nucleotidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_00287</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7N1"/>
    <dbReference type="OrthoDB" id="202825at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1210.10">
        <property type="entry name" value="Survival protein SurE-like phosphatase/nucleotidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002828">
        <property type="entry name" value="SurE-like_Pase/nucleotidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036523">
        <property type="entry name" value="SurE-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027746">
        <property type="entry name" value="TTL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004344">
        <property type="entry name" value="TTL/TTLL_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47551:SF1">
        <property type="entry name" value="TUBULIN--TYROSINE LIGASE PBY1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01975">
        <property type="entry name" value="SurE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03133">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64167">
        <property type="entry name" value="SurE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51221">
        <property type="entry name" value="TTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Survival protein SurE-like phosphatase/nucleotidase" evidence="2">
        <location>
            <begin position="12"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW94524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="710" mass="79307" checksum="D147B8038E96C472" modified="2019-01-16" version="1">MTVLQAINRHLLPNQQRSWIGKAHMIGQTVKPTYFRPGSLHNDDGTVHSRPSPASANQEEWVLVSGTPASCVQIGLYHYFQDKGPIDLVVSGPNYGRNSTAIFSLSSGTIGGALEAAVCKRKAIAISYAFFSRIHDPEIIAGASKLSVKLIDYLYNNWGKDVDLYTVNVPLVENVENKQIFWTKMLQNYWGHGSCFDEIQDEDGDPEDEEQKIREGEGAAESRSDETSGHKHKHFKWSPNLSDVYKSVEEAGPGNDGWTVKEGFTRQANFMHAAASTEGELKLPSSTPPLEKLSLSSESPSFLAHVDYEDSYVQPLILSALAERFPPGTFTNVESSAESTEPILHIGAYESLPFEQALSSSESLLVNAYIIRKALIRKHYLSTTAFNWITKNPLSILSTNIKPACEFELDYAEFLDDALVEAWELQTAFQKNEGRDAEDREWWILKPGMSDRGQGIRLFSTEEELQTIFEEWEVDQPDSDDEDSESAAKEDGDGDYIVTSHLRHFIAQPYIHPPFLIPGNPRKFHIRTYVLAVGSLKVYVYKPMLALFASKAYVPPWETTSSSSGDLSSHLTNTCLQDGQHDGSVQEFWSLPLDSSQKIDIFDQICQTTGEIFEAAAKGMMIHFQTLPNAFEVFGLDYLVDATGRAMLLEVNAFPDFKQTGDELKSLIAGLWRGVVDKAVVPFFGIDGQENSHRSEDSMVLVRDLDMGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7Q9</accession>
    <name>A0A3D8T7Q9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nuclear localization protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_00317</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7Q9"/>
    <dbReference type="OrthoDB" id="5598844at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013933">
        <property type="entry name" value="CRC_Rsc7/Swp82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597:SF5">
        <property type="entry name" value="LOCALIZATION PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08624">
        <property type="entry name" value="CRC_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="209"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="278"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="349"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="41"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="214"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="286"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="370"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="400"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="465"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="492"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW94554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="567" mass="61508" checksum="711891D1B1DC10E4" modified="2019-01-16" version="1">MSGGIPESPTQSSMPPSYSLPPQTPQSQHAAIPQQGGIPVTPTQASPTKSTPSKSVIKALPTVRDHTTDQLGPDGDEFIPREYDEAGEKKVTATGHLVEGRDYKCRTFFVPNRGDKLFMLATECARVLGYRDSYLLFNKNRSLYKIIASQAEKEDLIHQDILPFSYRSRQIAIVTAKSMFRQFGSRVIVNGRRVRDDYWESKARKQGFTEEDLAGEKRPGAAKARDAAAHEASTNASMTLGHHGDIVYSPGPGHPSFGGVLAQPPSVPGVIGASGNPSAYPMINVPDQNNPRDYSSLQRPRQEITGPPYQDRTQSSPPAQLLQEAHNTAEYNKHINAQSAQSRQFLQDKWNRPHEPPPTVTQPAVASESLPATQAMQSPRGVNSHHPGMPGPGTHMMAPQSYSQPTRQPSSLAQAPMRMAQQTSQIHARSPGLSLGPGGIGQGSGQYGFSQQNQMWPPSQPQPSPQHGLPSYNHPQQSPHFQSSPHQAPPQLRQQSSNPQMPSAFQYPGIQGVGQGYPAPGQGLYQQDRGSQHFMQQTSAGTQPGAPGWSAPQQPPGPGSNWGWSGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7X7</accession>
    <name>A0A3D8T7X7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">TATA-binding protein interacting (TIP20) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_00387</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAND family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6260732at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010265">
        <property type="term" value="P:SCF complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039852">
        <property type="entry name" value="CAND1/CAND2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013932">
        <property type="entry name" value="TATA-bd_TIP120"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12696">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08623">
        <property type="entry name" value="TIP120"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25782">
        <property type="entry name" value="TPR_CAND1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="TATA-binding protein interacting (TIP20)" evidence="5">
        <location>
            <begin position="1163"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="370"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="370"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW94624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1353" mass="146412" checksum="F3FEC7BDF418F2BE" modified="2019-01-16" version="1">MSNNSSIPAVPTSQTVAALLPKLQDADPDYRFMSLNDLFQVLTIGKPDFLHNDYNTAARTVDGVIGTLDDQNGEVQNLAIKCLEPLVSRLPSSILAPLIEKLSNLSTENSVDNSIPAMALRSVVITLPRPVPGVSPSKEVSEAYSAISRVLIPRLVGKLVVPKSTRLVKLPAPPPGMLDLDGTKDIDPEAVDVLIEVVRCFGPMLHQNEVEALQNLLVTILETEKASSVVKKRAVVAVSILAIYLSDEALSAFVSQLIESLRNPHLTLVQRRLYITILGSMARSIPSRFGPYLKTLAPFVLSALSEQELEEQRENAAEDGEPDPEIDDVRESALVALEGFLASCGNEMRSYTEESITAALLFLKYDPNYNDDDDDEEMSGTQPDDDDMDDFGDDDDFEQDAGFDDDDDDSSWKVRRCAAKALYTLISTRGSGDLLDDGTLYSQVAPMLVQRFNEREENVRLEVIATLSSLVRKTGGGVVVNLSIEEGADYISPVTPSRKRRRESSTAASFDTKALLSLSAGLTSPILEPVPASGPKADLARLSPSIIKVTNKLLKSSSIPTKQALITLLDDMIAVQSGGLSEYLSQLVDPIIDAIKTSSGTTSSTMTVGGATSATATTLRIAALRLIGDICKTHSSSVLQPHLPKIIPAIVAAVNDKYYKISSEAIGTVEQFIKALTPPRSRSFEQSHGAEFQKLYQVVVNRVTANDADVEVRQRAIHALGILLARTASKDDDSLLSAADRTSALDNLNDRLKNETTRLAAVRAIDTVAALTTSKDQLQPQWIREVSIELSAQLRKANRSLRGASLGALKNLVLSPAARSSLDATTIKGLTSALYPLLTVSDLHLLGPALLVLAALVLDDASLVVTDELNIALCGLLTASLSGSVLDAVLVLVTNIGQAGVGQPLMGGLLKDVSINGDPSVVGKVIGTLLVYGGSSVGVTIDSFLAEVQNPASDDARKSLALAVLGEAGLRLGGKSPLKPAIFTEQFDSKSDKVPLAAAVALGRAGAGNIPVYLPEILTIMDKGGNTQYLLLHSIKEILQQVGTNSADISNYAKAIWDRLLSASQSEDNKAVGAECIGRLAIIDPKAYMPQLQTYLEDKSPTVRAMVIQAIRYTLPDSDETFDAMLKSTLIDMLSVMLHDSELENRRLALTTLNSAAHNKPDVILPHLNKLLPLVMKESVTKPEYIREVMMGPFKHKVDDGLEVRKSAYETLYSLLETAYSRINVLDLFDRIIAGLQDEHDIRSLCNLMLAKLVALDPDETARRLDSIAPCFRAILMTKLKDTAVKQEIEKQDEATRGALRVTLLLHAAIPGASSGTSAQGIQHQIWRDYWEWVEKDFEPQLRAVRQENKESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T881</accession>
    <name>A0A3D8T881_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_00487</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T881"/>
    <dbReference type="OrthoDB" id="3596006at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW94724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="249" mass="27069" checksum="89C01BB3F2352649" modified="2019-01-16" version="1">MAVIWGLDLKEMQWGKFKGSYMFNQEYHLRRTKMIVYQFAMILCVVSESVGTAALSDYVDEQDGISTRSGGRALIHNNDIVGILSYNIFIGIAVATIFGSGFFFDLFWPERKESNGVRLAWKISAIAVCLGALGDALALTVIVATHAAFITGVSATEAATLIRNNSGGKPTLVYRHNPYCVASVVLLWLGVVATFASTYILFKSHKHDDALGPKSAQARRRDEEAHVGTQSASNNNPAFAPQMAQVGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8I0</accession>
    <name>A0A3D8T8I0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">EXPERA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_00071</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8I0"/>
    <dbReference type="OrthoDB" id="5415655at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047750">
        <property type="term" value="F:cholestenol delta-isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016125">
        <property type="term" value="P:sterol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007905">
        <property type="entry name" value="EBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033118">
        <property type="entry name" value="EXPERA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207:SF1">
        <property type="entry name" value="EMOPAMIL-BINDING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14207">
        <property type="entry name" value="STEROL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05241">
        <property type="entry name" value="EBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51751">
        <property type="entry name" value="EXPERA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="197"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="EXPERA" evidence="8">
        <location>
            <begin position="45"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW94308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="248" mass="28077" checksum="AA673ED7D3CEF940" modified="2019-01-16" version="1">MAAPVPSIMDFIDETTILSLAGVLVLLVSAYITSLYLLSPSTPGRLRVLFIWHAFDFLIHSVFEGSYLYNCFFSSAPFAPESSHPAAITNFLSRPDRLYGAAYADNWASKLWMVYAQADKRWAGADLTVISLELLTVFVAGPMAAYICYGITRRDIRVSFWMIVLATAEIYGGFMTFCPEWLTGNVNLDTSNFMFKWVYLVFFNMIWVFMPLYVLYIAFVDINNAMLVRNGVVAARLDMMEKEGKKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9P4</accession>
    <name>A0A3D8T9P4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_01065</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioesterase PaaI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9P4"/>
    <dbReference type="OrthoDB" id="2831072at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039298">
        <property type="entry name" value="ACOT13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660:SF9">
        <property type="entry name" value="THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21660">
        <property type="entry name" value="THIOESTERASE SUPERFAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="65"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW95302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="186" mass="20574" checksum="02B2B39DC6D519B9" modified="2019-01-16" version="1">MASETKQKAIKAVEAIFDRYRLIAAGTNFNGFDRHVMDNCKIINASPEGVVEFEFLIDERYGNLNGVMHGGAAGVIFDMCTTSALGPLAKPGYWDFLGGVTRTLNISYLRAIPIGTTVRLKSVVTSAGRTMAMIRGTMASVDGKTIYCTAEHHKVRVPTQPEHNKYRVEWDDMWDAEGKEIIKGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9U6</accession>
    <name>A0A3D8T9U6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytokinesis inhibitor byr4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_01079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9U6"/>
    <dbReference type="OrthoDB" id="19159at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990334">
        <property type="term" value="C:Bfa1-Bub2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031578">
        <property type="term" value="P:mitotic spindle orientation checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034586">
        <property type="entry name" value="Bfa1/Byr4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35140">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BFA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35140:SF1">
        <property type="entry name" value="MITOTIC CHECK POINT PROTEIN BFA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="708"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="769"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="833"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="918"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="458"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="494"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="593"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="623"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="769"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="837"/>
            <end position="846"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW95316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="999" mass="109438" checksum="3E2AF11564411860" modified="2019-01-16" version="1">MESLTLKPREPVVEEAIENWDDDDLDIGGDDFTFRSASIATTAPSHHRDSISSRLSIRSDFESTNGDEERQVHLPGDDEKSTTDAIATAKRAGIPIPQNVPSSALVGGTIKRLGGRKIRKIIQDDWDDGDLELPREGGFKIKAQDASRFPDTLRQVSGPGSSPPKSLQAAPIFDLKSQADQQARLTSANLERFRDDDEDDFFGDSGATIKVAKSRQGPKLIPLITPPTPQRVEGGDEDFDKDFQLPSEDTPLILSSHKDIPKTPVSAHEDLDGWGEGSLGTRFGGTRRDGRSNRSSSISALSPSVSNVSSSVTIESEDEGLDGLVLPSGPLRFDDILKKKQQDRSPERMHNDAKAGNFSAPTATDDFLSGLEIGDGDVFSSKKLTLNRNVRVKATRQASPTRPKTAVSLTFTNKPAPAVGSRLPRPLGHERVQSSSLEPVSESGGPIAARNRRSQSRLSGHSAQSSISSIPTPTTPSSTHSQLPSTPRRRELSSKLSATTLRNEPTTTSAQLLKLKRSMPIMKSFSDSPAKPVIPRYGRPPSRTDTNSRPNSMSRPKTPVDRDRSGADSSLSHSRKPAPFLPAGGFNAQSHHVTIKTSRHFRRHDSESSIHSGEFRPSSRAVSRSTMRSPSPRRTQRGTEALAREAAGKRQITKPVRRRHFGDGCELDGFDDLPTSQQAEQKFIKQPIARGAPKSLLRNMIHQNIVPDRTVSPAPLSPYSPVKSHDNLPRFARDTTASRMAREHVLSQRAPSGSGAPLATLTNQWKAQVSAKTGLTSNAQSTIRPKKTRGPPQKPQLIKPLGNINNPKSIKGMRYDPEMFRWVGNENDLTSFDVPASSPTTGSIPASSYREKDASTPRPALITNINASQGVQVVGGMVFDPQRMCWLKMAPQSAGKSDASDTMDGFDAFDDEEDVFKDVPDLEDSPTKADAENGGGRKSEGLKDEWLVGEEFDVGPEFVKRQREEEERWRRKCERWVGAQREEQGDAWRWSIRDVVGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9Z2</accession>
    <name>A0A3D8T9Z2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_01100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9Z2"/>
    <dbReference type="OrthoDB" id="10341232at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW95337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="354" mass="41156" checksum="DFF36F9C83F165C4" modified="2019-01-16" version="1">MPPFLNITHSPVILFSARFECATEALGKYAAARLFFLARSKYETEEDELVTIYIPSQCSKPDPQIWTVPSSLLYRKAPFLESLQKTSVPTYFQGMKSEIDRTIRSTRTIELPDENPKIFNHIISWVQNHEVFVGGDNIKEEEKEETHISEWCQLHVTASKYRIKALAIFALRKYIHGSRKAVVLDPESFWFPTVAEVRLAYYAPSLVDEEGDGRHHRENQEQVTSLQDDTKKLLRSTLAHILASHLLSTLFGSKEDMEHWFRITGAHRVFWKDVMQALKAHMWERRERCMGVACAVHDILEHPWIEEGDIEDVGDGVVESFECSYVEKRVKRKIDDHREEKKKRKRADVILLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q6V3</accession>
    <name>A0A3D8Q6V3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Biotrophy-associated secreted protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q6V3"/>
    <dbReference type="OrthoDB" id="2132010at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017690460" description="Biotrophy-associated secreted protein 2" evidence="1">
        <location>
            <begin position="21"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW57390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="123" mass="12000" checksum="2B52FF400FD43AA2" modified="2019-01-16" version="1">MVYINSIVAILALSFSTVLAVPGPYFPIVNSVSVRAAGGNVTTVNAGAAAVGKGGCINDADCGTQCCAGGAISGSTGRAGVGVCSGKGAGVEFQKGKTGCGFQDPNAQLTLQEAAAQVKKQGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q7H1</accession>
    <name>A0A3D8Q7H1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_12550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q7H1"/>
    <dbReference type="OrthoDB" id="446723at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="129"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW57749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="401" mass="44171" checksum="3A04093B8CD84B08" modified="2019-01-16" version="1">MTAGETAASFFKYASISIAVVVGLYATLLGLLTTSTVQSHVVYLHAIQMTWFKDLNVPETFGFLKNQVTPFSIKTSDGERLYAWHILPAELYRRHEQPLVAEPVGFVSDITSRLAFQLLRDNPEARLIIHMHGAAGTVGSGYRVPNYRALSAGQPGKIHVLTFDYRGFGRSTGTPSESGLILDGLAVVEWAMNVAGIPPSRILIFGQSMGTAVSIAVSKQLALQSPPVVFAGTVLVAPFVDTARLASTYRVAGTIPILSPLARFPLLFNYLQCFIWDKWLSKDNVAQYIRANEANDEKYRLTIIHAEDDYDIPWHHTPILFWHAVNASVPAGISYNDLELRKLESKVDLGAAGSVMEWRTDNGVIREEILKTGLHDVIMGYPVITMAVMRSFAAVDPAFTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QEB0</accession>
    <name>A0A3D8QEB0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_11782</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QEB0"/>
    <dbReference type="OrthoDB" id="5415512at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="467"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="502"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="588"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="699"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="753"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="797"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="909"/>
            <end position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW60176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="927" mass="105857" checksum="07B8F26C4E74B01F" modified="2019-01-16" version="1">MLTVYQPAKSASKEASEDEVEEVILPAKRPYLTKINGRLVMARQKHDRSASAMNLLGEAFGLNTTRVVRRRPPSLECEKTVPVYKTLPSPQRHYYPTNYASPDPIQAVSSPILLYPANTIQVVAIAPPQLLPFLPRRISIQTINSQAASEQCRVIGEDLAQLHLLDAHYRTYVAKNEDKIPIENAGEKQIPCTTAVTDQQDSSKTTTTITKHVCAGCGRLRSRKYHHNNPIQSGEQAKQTFCRKCQKDPSSTSSDDNDQVEKRRKNKQKRKKARKEKVPPAYISIITGEILNFTQDSESPSSEAVEIAAQASNKPAPGIEKAPHRTLKIKEIKRRPSAEYIVVEEYESNDQPQENGRSTTWRYLEESDISSRMQTSHTVGRNKSTSHKNYQTSMTAREPIPPPAADNFSPSDSSHLPKRQGQHYRLSPRSKGYKKGGVRGYDDHLHRPISHSVIQARRRGSQEYYEPFDHEDSQVQKDSHPREKRHYLEDQSKRYTPSPTWHYHDPNTLVEHEPFIEDQRRSQDYPEGRYSPDFAENSFPQSYADQVEARREHPQSRQQRDRPTYQERSREHFETSHHPTYKGRQDQENFQEQPPAQSSFTRRRRERQSPDSPLLGARPWEKPPEIRPEDGDEVVIVTERFTYLPKNSSVSRNPKTHFENPVQASKYYEDWLTDDSDEGNQHRERLARKATYGAITDRSGAEELRRAEKVAYQSLPRAPSPPSPPHRFGSSNKVPNMPPYPRSSDSDLEMEVEVERLDDPHIRLVMPGNKTSSSEKVPSPLFDNPSPERKQRRRGRIARDSRELSKARARSVSNHRPPYVGEATDGGAEIASIFPRHQYDGSQSTDALGDENKSEGNRRVRFMSPESAVTASEDSSETVRNLEPAVHGDEDSTVTEEYEIPRKLKKKPAKVEVSGRNDRSPTEHGHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QEK0</accession>
    <name>A0A3D8QEK0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ABC transmembrane type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_11861</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QEK0"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF399">
        <property type="entry name" value="ABC TRANSPORTER ATNG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017603628" description="ABC transmembrane type-1 domain-containing protein" evidence="9">
        <location>
            <begin position="25"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="61"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW60255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="264" mass="29054" checksum="A489CC144C92ECF7" modified="2019-01-16" version="1">MSVKTWIGVYALFALLELAGIALACVAQIREEFALITASGRYRGSAARKLCNEDSNMLENSAPMSVLTKIETGFLVSTFSQDMRLIDDPARGSCECLIACVTGAILTTIAVKYMAALLPFLCGALYLVQIFYLRTSRQLRLLKTETKKPLHSHFIETQARLTTIRAFSRYAKASQQNIDLLDALQRPFYLLLSIQRWLTLVFDLIVAGLAIFLITLATTLRSSISAGLLGIALVNGMSLGSTLSNLIQFWTSLETSLCAIARLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QHZ3</accession>
    <name>A0A3D8QHZ3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 4">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_11249</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QHZ3"/>
    <dbReference type="OrthoDB" id="283575at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17178">
        <property type="entry name" value="SECRETORY GRANULE PROTEOGLYCAN CORE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17178:SF0">
        <property type="entry name" value="SERGLYCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="559"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="3 4">
        <location>
            <begin position="625"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="779"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="803"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="780"/>
            <end position="795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS01186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW61357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="928" mass="97005" checksum="7061A42200161D53" modified="2019-01-16" version="1">MEAGLPPEMPPPVQKPFENPRKTPSPNQGRPRPPLPQALQGQGPIGVAISRPTQVPQWPLQGALDSPENERSQYQPPAGRGPAPQRPPRPSRVPSILDASRLQEHTPAFQYKPQQSLSPPGQRDKYDDDEELTSPGSRSAMTSASSRPSTVSSVGTIPDFPIPNIPVMPTPPRRSANLGPPPSSRRGASSYYSQISYVSPIPEENTPTRSHGSYASSAAIPSSWGSDSNYDALDSPTVDMRDDAIEEGRESRGSNDDNDERGLVRKASVGKRVQPSIITTSSSEKGPQRQEAANIGKPGSKLERMGVLPLASPNPKGGTEAGLEAPRATARPETTWPNSEDMRSPVNGRLAGGTGLIDSSSEETIPTLATAVTTDNRVPAQIFNSEDPKAQEMLAAYNGASSLPAGGVAPTRTPSQRFSRLSAIRRPPRLDIDAVRTAEARGSLTSLPDLIRRATRLAAMMDRGRRPASRINDLNDFPFAGDEKSSGEERSSPPGDEKYRSGLSGMLAAFPPPGVATPRETSPRPVSPWPSPYAAESLGDIKNGGQPKRSRKCCGLPCWGFILIILIIIIIIAAAIVVPLELLVFNKTKSNTAKSTSSTSLSSCMTQLQCQNGGINTISSGICSCLCTNGFTGTTCTVGGTPGCSTTSISGSSSNVTIGDAISRLLDGAQTNFSIPLSSTIIVARFNTASLSCTSENALVTFDGQNTRQGSAADVVVATASLNSKLVDTTSTANAIQSDPSGKTITITFGSAIDGLTTLPTAGTASTTLATAGTSTTSLETIPTAGTSTTSLETISTARSSSTSLTTASSSSKTTSSATTSKTSTSASATASSTAGFVVTQQVLDFSRVAVLYVLQQESVDNAISAQSALQSFLSLTSPSIAAAANLSIGNSNTINLNNFKIDVGNGTVGSNNVASRRRRWDGRGLSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QI19</accession>
    <name>A0A3D8QI19_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_11385</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QI19"/>
    <dbReference type="OrthoDB" id="566138at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42678:SF34">
        <property type="entry name" value="OS04G0183300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="29"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW61493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="508" mass="54643" checksum="32B982331D3AA883" modified="2019-01-16" version="1">MTDRSFNVLSATAVELQDMMTLGTLTSVEVLERYMDQIEKHNHAGLKLNALLSVAPRENVLAQAKALDDERKHGITRGPLHGLPVVVKDCIMTHPSLGMKTTAGAYAFANAEPKKTAAVLQQCINAGMVILGKATLTEFCGHRASEFDPGYSAYGGQTISAYDPRTPEQRKKSTSSIMQESACGGSSSGSAVAVSAGSSPLSIGTETGGSLVYPAGKNGLYAIKPSKGSVSSDGSFRISSSFDCIGAMAKTPADLALLCETMLIPAARNQLPAVGYQHFMTKSWDGVKAAFLDLKWADPPQEKWQSPGVKSKFEDVASTINELGGKAVYPVRLPEPNILNHEGQYLHQIAFFEFPAVFEEFCEQFEKTAVHNLGQLIKFNEENKDLAMPQPSPDQQPLIDSLNSPLSGQQAEEAYVAVKSLARAEMDKLMAEHDVELLVSNSDSGIVGFAATAGYPTSSIPLGIFEATGQPYGMFVIAKAGREDLIFRFMSAYEATFDKLPSPPLLRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QI83</accession>
    <name>A0A3D8QI83_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carbonic anhydrase</fullName>
            <ecNumber evidence="5">4.2.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Carbonate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_11387</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Reversible hydration of carbon dioxide.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>hydrogencarbonate + H(+) = CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:10748"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="EC" id="4.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="4">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="4">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the beta-class carbonic anhydrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QI83"/>
    <dbReference type="OrthoDB" id="10248475at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004089">
        <property type="term" value="F:carbonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1050.10">
        <property type="entry name" value="Carbonic anhydrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001765">
        <property type="entry name" value="Carbonic_anhydrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036874">
        <property type="entry name" value="Carbonic_anhydrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175:SF3">
        <property type="entry name" value="CARBON DISULFIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43175">
        <property type="entry name" value="CARBONIC ANHYDRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00484">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00947">
        <property type="entry name" value="Pro_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53056">
        <property type="entry name" value="beta-carbonic anhydrase, cab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0456">Lyase</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 5" id="KW-0862">Zinc</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="98"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR601765-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW61495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="179" mass="19565" checksum="0D9FCCDC359036D8" modified="2019-01-16" version="1">MAQNPLATKILDQNRTTAANHQPIPFFSELSGLGVKTPNTIILTCVDPRVTPEKFLDLSPAINPITVRNICGHAGPAIADIAALDAFMGIENVVVIHHTDCGALSFTEDMIKNRLKERLPEKGEEIDGMVFGAINNLEQSVRDDLDILRASPYIRKELAEKCIGFVYDIKTGLITPVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QI93</accession>
    <name>A0A3D8QI93_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative ribosome-associated complex subunit SSZ1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_11282</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QI93"/>
    <dbReference type="OrthoDB" id="29851at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10232">
        <property type="entry name" value="ASKHA_NBD_HSP70_ScSsz1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000009">
        <property type="entry name" value="Heat shock protein Hsp70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF32">
        <property type="entry name" value="HEAT SHOCK PROTEIN PDR13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="483"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="489"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW61390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="564" mass="60235" checksum="977D795E5D5310C8" modified="2019-01-16" version="1">MGEESATNGSAPAQRHAIGISFGNSNSSIALTVEDKAEVIANEDGDRQIPSVLSYVDGEEYNGQQAKAQLVRNSQNTVAYFRDFLGQEFKSIDPTHNHASAHPIAFESTVAFEIQDKEGDEKSTVTVSEITTRHLKRLVQSASDFSGKSINSAVITVPTNFSESQKVALIKAAKDAGLEVLQLINEPIAALLAYDARPESKVADKIVVVADLGGTRSDVAVVASRGGMYTILATAHDFDFAGVHLDKVLEDHFAKEFIKWNTTDPRTIPRSYAKLKLEAEACKKSLSIGTNASFSIESLAEGADFASTINRLRYETIGRKVFEGFNRLIEGVVKKAGLDVLDIDEVILSGGTSHTPKIANNMRSIFPETTTILAPSTTPTAINPSELQARGAALQASLIESFEAEDIEQSTHPAVTTVKHLTNAVGVLAITGDETKGVFTPVIVAETAVPARRTIHINAPPAGGDVLIKVVEGGSHIKVTQIEKTAEEKEADAEDSDVDSDEEPEEKREKIWKIGKVLAEAAIKDVKKGGKVEVMINIAGDLAVTITAREVGGKGGVRGNLSAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QM04</accession>
    <name>A0A3D8QM04_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">HAD-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_11168</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QM04"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.240:FF:000001">
        <property type="entry name" value="Haloacid dehalogenase-like hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.240">
        <property type="entry name" value="Putative phosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006439">
        <property type="entry name" value="HAD-SF_hydro_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041492">
        <property type="entry name" value="HAD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023198">
        <property type="entry name" value="PGP-like_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01509">
        <property type="entry name" value="HAD-SF-IA-v3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901">
        <property type="entry name" value="2-DEOXYGLUCOSE-6-PHOSPHATE PHOSPHATASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18901:SF38">
        <property type="entry name" value="PSEUDOURIDINE-5'-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13419">
        <property type="entry name" value="HAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW62866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="275" mass="30370" checksum="0073B9D5D0A78914" modified="2019-01-16" version="1">MATARKDFPPVRACLFDMDGLLLNTEDIYTVCHNILLAEYGGPPMAWSIKSQLQGRPASEAVALLLNWAGLSHVPIEEYMQKLKIIQAEQFPLCKPLPGVEALLKNLKATGTRGDKKVHMALATSSHTLAFNIKTERWTEMLEAFTPERRILGDDSRIPAGRGKPSPDIWQVALRAINDTLEEGEEKITPEQCLVFEDSVPGIVSGRRAGMRVVWIPNPGLAVEFKGREDVVLAGRGEGSLKDEHQLGVSGDGWGEQLITMEDFSYEKYGIAISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QM07</accession>
    <name>A0A3D8QM07_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Plasma membrane fusion protein PRM1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_11165</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cell membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the PRM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QM07"/>
    <dbReference type="OrthoDB" id="5356111at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032220">
        <property type="term" value="P:plasma membrane fusion involved in cytogamy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026777">
        <property type="entry name" value="PRM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31030:SF1">
        <property type="entry name" value="PLASMA MEMBRANE FUSION PROTEIN PRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0184">Conjugation</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="419"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="629"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="662"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="688"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="715"/>
            <end position="752"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW62863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="752" mass="81330" checksum="C75B2183ECC77451" modified="2019-01-16" version="1">MSPLATLRQFLASHTEMSSARNSPPGYPAVPPSLNAGDHELQDYYRPSSHSAPPTTVPYYTPYLGLRARLSQVWINRWTILLVLIICRLLLAINDINHSIAQAKTQALSACTSVENVGSAMASMPHYLSEGVNALAADGVTHAVNGLMDMLLLTVTGVEEIVLFIINMMTSTYVCLITLAISGSLHVAIQMIEEVGAFMNKSIASLTGNLDSDISSFTSSLNKFLAGLSDVTGLFGGSSSPPTINLNSTIDALNSIQVDPTTMDADLTKLNNSIPTFAQVQNFTNSVIRFPFEEVKKLINESVSGYTFDKSVFPVAEKQALTFCSNNDAINNFFTGLLKVIKEARIIFVVVLTVLAVLVCIPMAYREIWRWRTMQQRAILLQKNSFDPMDVIYIASRPYTTTAGIKAASKFKSTKRQILVRWAFAYATSLPALFVLALGIAGLLSCLCQFIILKVIVKEVPILANEVNNFADTVVNALDNASSAWAVAANGVINSTNTKVNSDVFGWVNTTTSAVNSTLNTFSDEMISALNTTFGGTILYTPILGVFNCLVELKIVGVQKGLTWVSDNAHVTFPEFQPDVFSLGAAASITNSSSTESFLSSPGSVASDDITSAIVDVANYLQNGIRTEALISTALICIWLVIVLIGLMRVLIAMLGREKTRAEGGPVGYTGDNRAALSPRSPNRFDRSKFPQFGGPISSVHPTKSTEDMWASRAANEDEKFGHVGHRSVEASVKPGHERSSSYGYLDGKEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QU33</accession>
    <name>A0A3D8QU33_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">G protein-coupled receptor GPR1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_10048</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QU33"/>
    <dbReference type="OrthoDB" id="5368598at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004930">
        <property type="term" value="F:G protein-coupled receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007189">
        <property type="term" value="P:adenylate cyclase-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023041">
        <property type="entry name" value="Glucose_rcpt_Git3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022596">
        <property type="entry name" value="GPR1/2/3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR 157-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23112:SF37">
        <property type="entry name" value="G PROTEIN-COUPLED RECEPTOR GPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11710">
        <property type="entry name" value="Git3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11970">
        <property type="entry name" value="GPR_Gpa2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose receptor Git3-like N-terminal" evidence="7">
        <location>
            <begin position="2"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="G protein-coupled receptor GPR1/2/3 C-terminal" evidence="8">
        <location>
            <begin position="204"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="145"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW65356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="32953" checksum="716982F01D92944A" modified="2019-01-16" version="1">MVVIALQIALLVFRQYHDPAFGGLYKYRYIIYTLCVLFPGLMASLAFTNPKGGYIFLGAFCYLPREPIWYRLSLAVIPRGAVFSVILTLHSAIYLYTVGSLKEFMRVDAQSAQKFLGHGQANGKQDSHQAPMEFVTSCVTRKSEVEPTSVLPTRPPREESYPADTEKCNSHPDQEGSFAHTSAIPTQTFESEIASSGVSNVFHKREEIQHHVRLLLIYPLIYLGCWVFPMICQIVQFSKANEGGAVPFWMALVWGMILAAQPGLEALIVSARERPWRKKEKVSLSESRRVSNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUL2</accession>
    <name>A0A3D8QUL2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">nitric oxide dioxygenase</fullName>
            <ecNumber evidence="4">1.14.12.17</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BP5796_09886</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">In the presence of oxygen and NADH, it has NADH oxidase activity, which leads to the generation of superoxide and H(2)O(2). Under anaerobic conditions, it also exhibits nitric oxide reductase and FAD reductase activities. However, all these reactions are much lower than NOD activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>2 nitric oxide + NADH + 2 O2 = 2 nitrate + NAD(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19469"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>2 nitric oxide + NADPH + 2 O2 = 2 nitrate + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19465"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16480"/>
            <dbReference type="ChEBI" id="CHEBI:17632"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.14.12.17"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.12.17" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUL2"/>
    <dbReference type="OrthoDB" id="436496at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008941">
        <property type="term" value="F:nitric oxide dioxygenase NAD(P)H activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019825">
        <property type="term" value="F:oxygen binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071500">
        <property type="term" value="P:cellular response to nitrosative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046210">
        <property type="term" value="P:nitric oxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009636">
        <property type="term" value="P:response to toxic substance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08922">
        <property type="entry name" value="FHb-globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06184">
        <property type="entry name" value="flavohem_like_fad_nad_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.490.10:FF:000003">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000034">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000010">
        <property type="entry name" value="Flavohemoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.490.10">
        <property type="entry name" value="Globins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008333">
        <property type="entry name" value="Cbr1-like_FAD-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000971">
        <property type="entry name" value="Globin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009050">
        <property type="entry name" value="Globin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012292">
        <property type="entry name" value="Globin/Proto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009805">
        <property type="entry name" value="PRK13289.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43396:SF3">
        <property type="entry name" value="FLAVOHEMOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00970">
        <property type="entry name" value="FAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00042">
        <property type="entry name" value="Globin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46458">
        <property type="entry name" value="Globin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01033">
        <property type="entry name" value="GLOBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0216">Detoxification</keyword>
    <keyword evidence="9" id="KW-0274">FAD</keyword>
    <keyword evidence="7" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Globin" evidence="17">
        <location>
            <begin position="2"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="18">
        <location>
            <begin position="149"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00049433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00056398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RDW65194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="409" mass="45161" checksum="FF227108EDDCD981" modified="2019-01-16" version="1">MSLSEEQISIIKATVPVLAEHGNTITTEFYQTMLDENPELYNIFNKTKQVNGHQPRALAGALYAYATNIDNLGALGGALENITQKHASLFVTPEQYDIVGKYLLEAMGRVLGEALTPAVLEAWTQAYKLLAGVMIEQERKLYAAHAEWADWKEFEVSKKVPESEEVTSFYLKPVDGRPLPMYRPGQYISVRAHVPNFSYLQARQYSLSDAHLGSVYRLSVKRDDGLHIAEGATTTQAGLVSNMLHGLNVGDRVQVSHPHGDFYLSQAAIDQSLPVVLISAGVGVTPLMSMLNYLVNSGSSQPISWIHGARRSTSQAFNNHVRDICKTHSNVHCTVFLKNPSDKDVLGETYQHAGRVSLAALDKEKDLFLGTEAEYYICGPESFMADIKRDLIENGVVESRINLESFGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUT8</accession>
    <name>A0A3D8QUT8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_10315</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUT8"/>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058846">
        <property type="entry name" value="PAS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF72">
        <property type="entry name" value="OSMOSENSING HISTIDINE PROTEIN KINASE SLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26131">
        <property type="entry name" value="PAS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="746"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="1046"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="1103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW65623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1194" mass="133122" checksum="24B1D08B1D04DC78" modified="2019-01-16" version="1">MTTRHDRVANPSPACGADSDVDPVDPEGTQLIEILELPLELRGSMLLAALDLDPRPTFIFNLEQTYQGGNARQPALVFCNAALNARHALRNVIKAQERKIVATWHSSLLATVDNSGELDTPLMLFALPWEFYTINGRWRVASTTRPAESALAFISSALTPPIAANTRQLQPPLELKAEAVNSRIEASLESTADPSRKAFIDNPSAFIRNFTPLLSSDFGQSLYHFNWASTQLGPIDTWSLQLLEMFKLMLADPRPTILYWGPQNVMLYNEAVVPLMLDRHPTSMGQTIEMIGENILKDLHQPLVARIKKTAQAETHVNTLLCYAKENDFLEEVYADCTSVPVIGADGHVSGVYQSIVEVTEHTLTQRRTNTLSALAAVSVQSRDLKGIWGNITTGLEANDKDIPHMLLYSLDARWGESVTLLKCKLEGSIRWAPKSNVEFETLNFYDQEHVLSNIFQQSMSSDVPLYLHQRQANRSGGEPTFDPSLYLPNFVDDFEPGPFGDPCGRVVVFPIRASITDEPMGFVVWGLNSRQPYNQTYRDFVSLLQRSLAASISSGLRWERELLRSQIAAEQAEMDHASLSAQLLQQTKEARANELRFSRFVQHGPIGICIYAPDGSKAFANEQWYSMTDFPRDGDSTGPSWWAPMIFEEDRAYATEMFTQLLVEQKPVHFEIRLVAPPKQASMAKKISTWTLVSAYPEVSNENALEAIVACFTEITEQKWAAEVERMRTEDAMEAKRQQEAFVDITSHEIRNPLSAVLQSAQEINSICQGQLNEAPDHTTNVSVSIEGLKDAVHAAEIIEQCTLHQKRIVDDILTLSKMDAGLLPVVASPAQPLTIVKKTLDFFLRELSQAATEMRISIDDSYTELDLDWLDVDTGRLSQMLINLTTNAIKFTKQQPERQIELRVGASTGSTRLEAWHLDYLTPTTHKIQTIGCDWPEHECVYLHFSVTDTGTGMTLEEQKTLFARFSQGSARTYTQYGGSGLGLYICRALVEIHGGQIGFSSVPGVGSTFGFFIKSRRSPLSGSRRLSTKHVPSKIVSRELVLNIMLVEDNLINQKVLSRQLSRLGHAVMIANHGQECLDILRQSHFCQESGSSLSVILMDIEMPVMDGLVCASTIRKMEAEGLVHAHVPIIAITGNAREEKVQQAKDAGMDEVVLKPFTVPVLMPLIDKLIQRYGKRIPRPDDITEDASLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QY39</accession>
    <name>A0A3D8QY39_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit WBP1</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_09448</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DDOST 48 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QY39"/>
    <dbReference type="OrthoDB" id="29105at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005013">
        <property type="entry name" value="DDOST_48_kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055459">
        <property type="entry name" value="OST48_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055457">
        <property type="entry name" value="OST48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23358">
        <property type="entry name" value="OST48_MD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03345">
        <property type="entry name" value="OST48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017497438" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1" evidence="8">
        <location>
            <begin position="19"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="434"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 N-terminal" evidence="9">
        <location>
            <begin position="25"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 middle" evidence="10">
        <location>
            <begin position="317"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW66699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="473" mass="52390" checksum="EA3D3933CA227578" modified="2019-01-16" version="1">MRWLLSFLFLGLLGVAQALSASGNRLLVVLEELDDKSKYSKYFGDLEGRGFQITYESPKSESVGLFTLGERAYEHLLILPSKSKGLGPNLTPKILLEFINKGGNILLTLSAITPTPTALVSLLLELDIHLPTERNALVVDHFNYDTLSASEKHDVVLLPRPDTIRPGVKNFFKGDGKGGEVIAFPRGVGQSLGNTSPLLTPVLRAPRTAYSYNPKDEAESLEDVFAAGPQLSLVTTMQARNSARFTVVGSAEMLEDGWFTGEVKRSVGMGGVGTDAKKVKTCNQAFAKEITGWAFQEIGVLKVGKIEHRLNEGVRSNITNPKIYRVKNDVEYSIELSEWSWDKWVPFTPVAEDVVQLEFSMLSPFHRLDLAASGTTTNSTVFTTSFKLPDQHGIFNFKVNYKRPFLTNVEEKNTVTVRHFAHDEYPRSWVISGAWPWIAGIAATITGWLGFVALWLWSKPVPLKLTTSGKKIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QY87</accession>
    <name>A0A3D8QY87_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_09390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QY87"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047975">
        <property type="entry name" value="Heme_bind_FMP"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040572">
        <property type="entry name" value="heme_bind_FMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW66641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="414" mass="43838" checksum="1DD413765D5D7A37" modified="2019-01-16" version="1">MAAQQIISAGSAPANPANASISLAPDFQICEIDDKFEPEIKSVKAPPSPPLGVLSRFTGKFCGKGLNLIFRPNSGPPTTTTFPNPIQPPAPTPPSENVLELNLTTETLSFSDPLGSIPNRGLETQNDIFLNGVPYVQAINDVTNTATGKADSKPTGIHFEPGLWMHIPATTADPVLGESLTRMASIPHGTTINAQCLAPTTSIAGPPKIEPVDITPFVIATGKKVKFASQTASDTATPRLPQDLSKFIAAGTITQAILDDPNTVLRNANMGKHITKTIVFQVSTTPTVPELGGGTANIAFLQGNSLGPNASAVQMTATFWIETVQHKIVVPMFKPGQPALKIKPAEPHPGAQVPVFSVNPPHEITEPKTITVTSTQIQYSQVVFLNFANLTWPHVSVATLVPTSEQTVPPSVWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QZ19</accession>
    <name>A0A3D8QZ19_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_09795</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW67046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QZ19"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="218"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW67046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="788" mass="88790" checksum="F684AE26EF17A23E" modified="2019-01-16" version="1">MDYIKSAIDDFTSASVGLGLRLLFSRYIWMRFVFTKTQPLPAHAFPILLACLWLYRASREIYELGSRHTRGFRLPPEQGWLVQTFLDQALVLLGYVVYARIIFPALERFIPFSRMVWIVIVELLYIFLNGWVSPRPHLQMLHSLDQHVHSALPKLAEKIRAVCFPDTSSLDEQPKEEYKHSAILQRQIRLIRIRRRPFRSDIECELVVRDLDAVGPFYAISYAWGNVLPLQDIAINGKGYKVTQSAFKVLHAVGDRFASKFFWLDSISINQEDTAEKTAQVRLMTDIYRKASATIVYLGSTGYLRGVASTMNNLSTIRSDKRSYRPEAMGAFSFLQGHNAPGYSQAVQALYSLPWFQRAWVLQEVAVAREVFFMWGTEFLSWKTLLSGVQDVMQYSVDPADVMIRSGLNSESVEFAETWIGHVNSFGKLASNIQSATAIHTMKMVQESIVSQQLPSLLDLLRQTHASASTDPRDKIYALLGLADPKSLNSIEVDYVTTPKDIYISAARRILSGSTSTDIILSAGIGVPRKMLGLPSWVPDWSCYPGPLLEGIMATITNPEVKLAKELSETEILNPYLATAGSEIDSIRKLSSTISEIEHKIKLQTSHLSAILYWIAGAIKFSNAHNLALTQDDSHLQKPSHGKPREARDAFDNQPLWRTILGRDFLLENKNILQKGSIKKTLKAGLADLTLNLDSDLNKICMRVYRRCWARRLCITKQNKISLVPEGAWVGDGIWLLTKLSSPVLLRKYRPVEVGQNTTGTLGQYLLVGQCTYDVVGGVVIDQVIVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QZ46</accession>
    <name>A0A3D8QZ46_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_09831</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW67082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QZ46"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="4">
        <location>
            <begin position="8"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW67082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="351" mass="38279" checksum="B8DF483D1039A486" modified="2019-01-16" version="1">MPTSEDLVLLTGATGFIGYVVLVKLLEAGYPVRCAVRSPSKIEQILSAPSITALGPIRERVSWVVVPDMTAQHAYDEGAKGAKYIIHVAFPIPSLGKQGPLVQDLEKIFIEPAKRGTIDLLETAKRAGSVKRVVFTSSIVAIIPDKYFLAKGDDRIFDAESRIPSPSGPYQDDKDAYRASKAIALNQSEAYIQSERPDFDIVSIIPGWVLGKNELLVHPDQMALGGSNSMLLSPLLGHKNQFHLNKNYVHVDDVAKLHVLALGAKVEGNQAFVASSDGLTCPDWEDAFPIVEQEFPEAVREGRLKTTGKQPSHSIRIDGTKTKDVLAIDLVPFKVQVKDVAGQYLKLFGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QZB9</accession>
    <name>A0A3D8QZB9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase M20 dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_09769</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW67020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QZB9"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990845">
        <property type="term" value="P:adaptive thermogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043604">
        <property type="term" value="P:amide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043605">
        <property type="term" value="P:amide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05674">
        <property type="entry name" value="M20_yscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.900:FF:000003">
        <property type="entry name" value="N-fatty-acyl-amino acid synthase/hydrolase PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000027">
        <property type="entry name" value="N-fatty-acyl-amino acid synthase/hydrolase PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017141">
        <property type="entry name" value="Pept_M20_carboxypep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047177">
        <property type="entry name" value="Pept_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962:SF1">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037217">
        <property type="entry name" value="Carboxypeptidase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="9">
        <location>
            <begin position="303"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="254"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="220"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="557"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW67020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="585" mass="64977" checksum="A7679F5570F678E6" modified="2019-01-16" version="1">MPQLKNMKPQSRNYTLLPSGERETPIPKQKPSRKKLWQWSIPVLLAGAVVVTLAVTNTSKSGEVKWEPNSSSPACPQFPALKPMGIDQTELQQKVMLEIDSDDFFDKSLKRLQGAVQIPTESFDDLGEVGVDERWEIFKEFHAYLEKTFPLVFSKLEITKPNTYGLLINWQGKDKSMKPYLFMAHQDVVPVLAVTESRWKYPPYSAHYDGRFVWGRGASDCKNNLMGVLGTLETLLEQDFVPERTIMAGFGFDEEISGFHGAAYIAKELEDKLGKNSIELIIDEGGLGIKEMYGATFALPGLGEKGYMDIKITVETEGGHSSVPPDNTGIGILSRIVAAIEDAPYSPDLTPANPYFTTLQCAAEYGPSISKALKKSIKKSLTSKSEAKALAEYLAKDDIKNRYLMQTSQATDLVSGGVKINALPEKVYAVVNHRIAVESRIADIRANMQTVLEEKILSKFSMSLDAWGSVSGNTSAKSTGQIILEDFSVPLEPSPVSPYDTDAYRVFTGTIKQVLGEDIIVAPSIMTGNTDTKYYWDLSKNIYRFSPVREEGRFNAHTVDERVGMKEHMEGIKFYTQIILNGEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R362</accession>
    <name>A0A3D8R362_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_09073</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R362"/>
    <dbReference type="OrthoDB" id="3034343at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001080">
        <property type="term" value="P:nitrogen catabolite activation of transcription from RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050797">
        <property type="entry name" value="Carb_Metab_Trans_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668">
        <property type="entry name" value="GLUCOSE TRANSPORT TRANSCRIPTION REGULATOR RGT1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31668:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="29"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="70"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="587"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="75"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW68416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="608" mass="68123" checksum="629F8A509FE911D9" modified="2019-01-16" version="1">MTNQQEANSSNAEAQVNVGRKYKSRKERPCDACRKRKICCTRDAFEKDCSLCKTRGESCKYVLPPNVRRNRQPTANASMSRVASSSSGTSIPPRPVANASASNQGSRSSKQAASEWICQFVGLSGDQDPFVLRHCSFNHLNCYKAPDWACIRVKGDTDVPLHFTVVPDSHLDARPDYYPTTDTEALVAPHSDALLRTYFDVVHVSYPLLDPSRFSHPPKTGDPLVAIMYNLAGPFCQEAEPYYKDLSHFVHRALPIERRHPRLETIEACLLHVQRHIAIPRAPTIPGLWGDVGAIVGMAHDLGLNVDPSTWNLSHSDAARRLRIWWALYIQDKWSALGLGRPSYLNDEHSNVPMITIDQFSHLGLHDEPIGLQPALQFVAMAHLTTILSDLLSTFYTLKAMERVKLLPIDVLYQVMDEFQSRIHNFHEEHLIQLYNVNTLLDSSGSTILAFYTVEIVLYRAMLRCLPMSDPGYPAIRENAKQTLLNITAFLEKLPVSRLRAFWWSPMTRINFAIAGGFAFFLLLTSITDDDITFWSAQIEHYRALLRLQSISFDMCKLACMRMDLLAAGMGVDPPALDNGLEEGEGVIAGNGGRQQAAKLTPGSAEEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R370</accession>
    <name>A0A3D8R370_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09065</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R370"/>
    <dbReference type="OrthoDB" id="5427732at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW68408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="425" mass="42714" checksum="813076EAAB9BFEA8" modified="2019-01-16" version="1">MAPTNGNAKARDLEQNISSVPNEKGSSCTNRELPRRTTKMPSIRNLLVGLTLLSLLTWSLVSAVPSNKPSAEDQQNFRQLLDSVEATCLHDVLHKLVPEKFKHGVFEEDKKAIAAVYEEDAARASSMIELAKRQSSNTTTVATSQATSTSVVVQTTGVSVTSTVVSTVPASSQDTPTPTPTPTPTTTATTQQGTTTTAVVTSQQASSDTGSPSSEQASSTIVVVSTPQPTTVVVSASTVVSSGSTVVIPGSTVVSTAQPTTITGTSNPASTIAASSSEIVVSSTSVFTSAGVLTTSVVVSSSNVLVSTSNPASTLTTSLPSATSNPSSSTGAPTTKAPTKSASATTKPNTSSRTTSIVFTTTFANGDVSTITSVTVVPAASDDAGSGASSTSSGQASLQTGGANSQSFNAGIFLGVVGIAVAGIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R3S1</accession>
    <name>A0A3D8R3S1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ubiquitin-like protease family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_09228</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R3S1"/>
    <dbReference type="OrthoDB" id="5065855at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019784">
        <property type="term" value="F:deNEDDylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044613">
        <property type="entry name" value="Nep1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46468:SF1">
        <property type="entry name" value="SENTRIN-SPECIFIC PROTEASE 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="152"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="176"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW68571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="188" mass="20997" checksum="D9CD77F884B72791" modified="2019-01-16" version="1">MAFMLMQTPDPLTLKDALPNFTHTTHIFLPINDARSVTVAEGGSHWSLLLVSVIDGVAFHYDSLSPSNFNEARLATQKLAQLLGRQLRFLNLEDSPQQENSSDCGVYVCIQMRHLLLSRLLSANAREKVSMSMGGKLVDANGGRKEMLRTIEGFRKEGERRRSVDQSSRSSSPFYKKGDSRSPPRIDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7H1</accession>
    <name>A0A3D8R7H1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">prephenate dehydratase</fullName>
            <ecNumber evidence="2">4.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_08402</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>prephenate + H(+) = 3-phenylpyruvate + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:21648"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:18005"/>
            <dbReference type="ChEBI" id="CHEBI:29934"/>
            <dbReference type="EC" id="4.2.1.51"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-phenylalanine biosynthesis; phenylpyruvate from prephenate: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.51" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7H1"/>
    <dbReference type="OrthoDB" id="983542at2759"/>
    <dbReference type="UniPathway" id="UPA00121">
        <property type="reaction ID" value="UER00345"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004664">
        <property type="term" value="F:prephenate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009094">
        <property type="term" value="P:L-phenylalanine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04905">
        <property type="entry name" value="ACT_CM-PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13532">
        <property type="entry name" value="PBP2_PDT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.190.10:FF:000034">
        <property type="entry name" value="Chorismate mutase/prephenate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.10">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002912">
        <property type="entry name" value="ACT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008242">
        <property type="entry name" value="Chor_mutase/pphenate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001086">
        <property type="entry name" value="Preph_deHydtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022">
        <property type="entry name" value="PREPHENATE DEHYDRATASE P PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21022:SF19">
        <property type="entry name" value="PREPHENATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00800">
        <property type="entry name" value="PDT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001500">
        <property type="entry name" value="Chor_mut_pdt_Ppr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53850">
        <property type="entry name" value="Periplasmic binding protein-like II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51671">
        <property type="entry name" value="ACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51171">
        <property type="entry name" value="PREPHENATE_DEHYDR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0584">Phenylalanine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prephenate dehydratase" evidence="9">
        <location>
            <begin position="12"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="ACT" evidence="10">
        <location>
            <begin position="273"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="133"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW70005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="361" mass="40202" checksum="0AF27CF97E9DDBB6" modified="2019-01-16" version="1">MAATSTSDGVPVVAYLGPQSSYTHQVPTLFHYEIPPWATGLTSHEMAQAALNYFEQSEYNYKPVRSIEAIFEAVQSGEATRGVVPFENSTNGAVIFTLELLADRHAWFKDVSVCGEAYLDVHHYLLGRTAPASATDSPLISGTSTPTPTTPAPLNPRTKPLASLRHVKRIYTHPQAFGQCEAFLGTYLKGVERFEVDSTSRAAEMVAEDTTRSSVAIASSLAAEIHGLDILGESIEDRADNTTRFFVIRKDVETDDDAIHAAATAEGPTKSLVSFTIDHREPGTLASALHCFKRYNLNLTSLNSRPSKLRPFHYIFFVEFWGSRWKDPYKEVDRVLEDLKGHTQSLRWLGSWEDQLRMKEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7N6</accession>
    <name>A0A3D8R7N6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Origin recognition complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_08434</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the origin recognition complex (ORC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the ORC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7N6"/>
    <dbReference type="OrthoDB" id="346673at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007220">
        <property type="entry name" value="ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056772">
        <property type="entry name" value="RecA-like_ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056773">
        <property type="entry name" value="WHD_ORC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04084">
        <property type="entry name" value="RecA-like_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24882">
        <property type="entry name" value="WHD_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 2 RecA-like" evidence="7">
        <location>
            <begin position="324"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Origin recognition complex subunit 2 winged-helix" evidence="8">
        <location>
            <begin position="567"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="236"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="42"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="75"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="112"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="166"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW70037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="636" mass="70451" checksum="63F2FC3691490A1E" modified="2019-01-16" version="1">MKRKKSFEDVEGELSNGDAPSPGPLSDTEDVEMHDAVDGTPSKKRSSINGRTHKSLTPSVDSTGAISASREAEENGSTTKSSTPAKKISRELARLQWESEGVKASKARVEDPLVEDEEEDYMDELSAPDQVGTPSKRTPMHPGSASRGQGIGTTPSKSTVRKNLFATPTKTNGIGKGTPTSTPKFNRTADRSARRKTTKSLIERTILGNTSDNEEDEASLLQVIYGSDEENEIVEGDVPGIASESVEVLATPSKRGRGRPPGSKSKPREPSPLPQNLGPPELYFAQNRGKVQTSNNTLTSLSLLDHEEYFSLIRKHDDPHTKDINFLQDTHAGSFNQWQFELNQDFNICIYGWGSKRELLSRFANHLYNTFDDPEKNRIVVVNGYVPTLTVKDVLNTVAAAVTDRGQKLGSQPAEMLETLVGLLERDPSQHVTLMINSIDGSPLRRPSTHTVLARLASHPQISLIASADHPSFPLLWDTSLRSTYNFLFHDCTTFQPYAVEIDVVDEVNELLGRSGRRVGGKEGISFVLKSLPENAKNLFRVLVAEQLIGMSEDDDVEDDDNDKRTGNQEVGVEYRVLYNKAAEEFICSNEMNFRTLLKEFHDHQMIESRKDALGTEILSVPFRKEELETILEDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R845</accession>
    <name>A0A3D8R845_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate reductase</fullName>
            <ecNumber evidence="3">1.1.1.302</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one reductase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_08498</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NAD(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27274"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2,5-diamino-6-(1-D-ribitylamino)pyrimidin-4(3H)-one 5'-phosphate + NADP(+) = 2,5-diamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27278"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58890"/>
            <dbReference type="ChEBI" id="CHEBI:59545"/>
            <dbReference type="EC" id="1.1.1.302"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HTP reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.302" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R845"/>
    <dbReference type="OrthoDB" id="5432at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008703">
        <property type="term" value="F:5-amino-6-(5-phosphoribosylamino)uracil reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002734">
        <property type="entry name" value="RibDG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050765">
        <property type="entry name" value="Riboflavin_Biosynth_HTPR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011:SF8">
        <property type="entry name" value="2,5-DIAMINO-6-RIBOSYLAMINO-4(3H)-PYRIMIDINONE 5'-PHOSPHATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38011">
        <property type="entry name" value="DIHYDROFOLATE REDUCTASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_8G06820)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01872">
        <property type="entry name" value="RibD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0686">Riboflavin biosynthesis</keyword>
    <feature type="domain" description="Bacterial bifunctional deaminase-reductase C-terminal" evidence="10">
        <location>
            <begin position="47"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW70101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="274" mass="29793" checksum="214AAFCC91334B6F" modified="2019-01-16" version="1">MPPSPVPLFFAADHQIQLSDYLPLPRTTFLQENTAEPPPPHPSTQLPHVTLTYATSLDSQISLQPGLQTVLSGPETKAMTHFLRSQHDAILVGRGTAEADNPGLNSRFSNDGQYAVGLDRQPRPFVLDPRKKLDPSRTPKLLENAAAGIGRAPWWIISDSEDVDQTIWTNVVRAGPYVGSESGIDWEILLNNLAATGVRSIMIEGGATVINDLLKAKNQKWVSSVIVTIAPTYLGDGGVVVSPPRSNATQNEARLTQVRWFPLGQDVVMAGKIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8I5</accession>
    <name>A0A3D8R8I5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Autophagy-related protein 101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_08683</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATG101 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8I5"/>
    <dbReference type="OrthoDB" id="10259639at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012445">
        <property type="entry name" value="ATG101"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13292:SF0">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07855">
        <property type="entry name" value="ATG101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0072">Autophagy</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW70286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="194" mass="22353" checksum="2F4FD8476555B59B" modified="2019-01-16" version="1">MDQRRPPEYIIEVFADPTSVKDVVRGILHTIFFHRFFPSIRPKTRDVLDLTLPVVEDVELETLIDQRTATLVRQLDTSSDMGARNTGVRGLMAVQFFEKKRRKAWFTKAEEEVCWEQWTLDVTLATPRTESERAKVRNAMEAMLLKAAMKIVSTVNREKDLIPPITTSESNPFPYQITVNPKGDGYWGARMGMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8J9</accession>
    <name>A0A3D8R8J9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CBM1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_08772</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8J9"/>
    <dbReference type="OrthoDB" id="2586582at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630:SF13">
        <property type="entry name" value="ACETYLXYLAN ESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="CUTINASE RV1984C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017682280" description="CBM1 domain-containing protein" evidence="4">
        <location>
            <begin position="17"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="5">
        <location>
            <begin position="261"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW70375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="297" mass="29797" checksum="224402B0725445F2" modified="2019-01-16" version="1">MIQPFVAALFVTGVIASPLESVLSLETRQSCPNIHVFGARETTAPAGYGTAGVVVNLILNAHAGSTSEAIVYPACGGQSSCGGVSYANSVIAGVAAVASAVNSYNTMCPNTQLVLVGYSQGGQIMDDAFCGGGDTNEGLTSTAIPIQASAVAMIKAAIFMGDPRHIPGLSYNVGTCQASGFAPRPAGFQCPSASKIQSYCDAADPYCCNGSDAATHQGYGTEYGQAALAFVNSKLGTASSTIITTAKTTSTAAPTSTSGSGTVAHYGQCGGIGYTGPTSCTTPYVCTAASAYYSQCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8V9</accession>
    <name>A0A3D8R8V9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative nuclear cap-binding complex subunit NCBP1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_08718</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8V9"/>
    <dbReference type="OrthoDB" id="10252707at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000079">
        <property type="entry name" value="Related to cap binding protein 80 (Cbp80)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.180:FF:000035">
        <property type="entry name" value="snRNA cap binding complex subunit (Gcr3)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027159">
        <property type="entry name" value="CBP80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015172">
        <property type="entry name" value="MIF4G-like_typ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015174">
        <property type="entry name" value="MIF4G-like_typ-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412">
        <property type="entry name" value="CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12412:SF2">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09088">
        <property type="entry name" value="MIF4G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09090">
        <property type="entry name" value="MIF4G_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G-like type 1" evidence="2">
        <location>
            <begin position="326"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="MIF4G-like type 2" evidence="3">
        <location>
            <begin position="533"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW70321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="808" mass="90998" checksum="9F7B1FCD471AC690" modified="2019-01-16" version="1">MADYDHRPRGGRGGYNNRKRRYRDEDDYDRRPQRRRYEEPLSVKVRKQLLAIAESPLKRVEDEVYSIAKVVADNHEDAELRKSFEDLALQLVVEQPFKTPFVASVVLAINALKSDFVDSIIAKAVTEFDSAISRGEWREVKLLMKFLGCLQGILEGDGVFPVLQDILTKAVELQTENSDDTLGPELVKIILFTIPYIMVSSGSDAIEKAASMIENTDIIASEPHVLQALVDPYPGNGKEDATPPTSVLQLLQKQLSNEATNGWELACLPRPWKLLQDAEQEITIANAPKHVLPPVNLPEVLVAGPRALFPELYFSVYANQDVETVPPTTDIASCLLRDALIDTINILDYNRNATAKFLIDLDCYFSPGTFVKRATPFDRLRDIDGDRSTWKPEDVAVDAVFSQLFQLPAPEHKLVYYHSVLTEACKIAPAAIAPSLGRAIRYLYRGVDSMDLELSYRFMDWFSHHLSNFGFTWKWTEWIDDVELPSLDPKKAFIQGALDKEIRLSFAQRIKGTLPAPYQQLITEEKEKDTPDFKYNDEATPFAADGRELMSLVKKKSPEDAIEPIITRIQSTAKDLNLPLPPLYYSTDAYVTSICYIGSKSLSHVLSCIERCKDRLLASSEARSQIIESVMAYWKDQPGIGVNIVDKLLNYTILSPDSVIEWALGKSGSNLSESAIFEMVAATVGKVTGRVRQVVKSTQEPDIPADEKATLQETVDRERQSMKELFELMEDKLTGWASGSKDQMLDGRGVTDEESAMIVQWGERYLRVFRRRGAVEEAWFLDQSKIVVPAAVEEMKVDIPEPETVEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8Y3</accession>
    <name>A0A3D8R8Y3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08738</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8Y3"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW70341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="62" mass="6482" checksum="30C50CBB75248279" modified="2019-01-16" version="1">MPVEQAPQAPQAPAPMSMEPPSDIEMQQPAQQAAMSTEEVTMRGGESAACDCCCCGCSEQCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCL2</accession>
    <name>A0A3D8RCL2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative UV-endonuclease UVE-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_07827</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RCL2"/>
    <dbReference type="OrthoDB" id="541883at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043504">
        <property type="term" value="P:mitochondrial DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.150:FF:000012">
        <property type="entry name" value="Related to UV-endonuclease UVE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004601">
        <property type="entry name" value="UvdE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00629">
        <property type="entry name" value="uvde"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31290">
        <property type="entry name" value="UV-DAMAGE ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31290:SF5">
        <property type="entry name" value="UV-DAMAGE ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03851">
        <property type="entry name" value="UvdE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0228">DNA excision</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2 9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="80"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="625"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="686"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="566"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="152"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="625"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="686"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="705"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="729"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW71793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="781" mass="87564" checksum="B16BDAB019A97226" modified="2019-01-16" version="1">MPPKRKRSTATTATGLNQDPASIVPPANNAIKPPASKRQASRQGKVDTNPDQNADIVDGKFALRASPDADEKGEALDISAINQGPPVTPASDPNAVVKEEAESDSALSELDEMPLAKKNKKAPTKSSIAAKKGSDEIKAFKAEQAAKKAAEMKIKKEDADEDVRADPDGDEGVAEDVDTMKKEAARPPPVNSDYLPLPWKGRLGYACLNTYLRFSNPPVFASRTCRIASILEHRHPLKDPTQPEHATKNRPDKSKPASIERGQKYVEELGVANARDVVKMLRWNDKYGIKFMRLSSEMFPFASHEEYGYRLAPFASEVLAEVGKVAAKLGHRLSTHPGQFTQLGSPRSAVIENAVRDLEYHEEMLSLLKLPEQADRDAVMILHLGGTFGDKAATVDRFRENYQKLSEKVKNRIVLENDDVSWSVHDLLPLCEELNIPLCLDFHHHNIIFDDTKVREGTRDIMDLYPRIKATWDRKRIKQKMHYSEPCPEAITGRQRRKHNPRPATLPPCPNDMDLMIEAKDKEQAVFALMRTFKLPGWETFNDIIPYERDDDNKPAPKKAKKKKTKKQIAAEIEEFGKELSEEEEVIKEIIAEDEVGMGGKEDRVFWPVGMEEWLRPKKREIKKKEQGADENLKEMMRNPTPANFEARKKAQAAAKSNLLLPEDVKERLKTVSSTADIQALLDEMKNLTGDEKSSNIKIENSKKTPAKKTSAPKKRTARSVPTPSVSTPDEEEDEDESMLDLSDDEADAKSLRPKIPPSRASGRAKGKRMSYADMDEDELH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCM4</accession>
    <name>A0A3D8RCM4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_07809</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RCM4"/>
    <dbReference type="OrthoDB" id="10264538at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00499">
        <property type="entry name" value="Ribosomal_eL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001380">
        <property type="entry name" value="Ribosomal_eL13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01294">
        <property type="entry name" value="Ribosomal_L13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="190"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW71775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="215" mass="24466" checksum="8CED7CA5F2D8A4B6" modified="2019-01-16" version="1">MAIKHNQQIPHNHFRKDWQRRVRVHFDQPGRKLRRRNARLSKAAAVAPRPVDKLRPIVRCPTIKYNRRVRAGRGFTITELKEAGIPRKMAPTIGISVDPRRQNLSVESLSVNVQRLKEYKARMILFPRKLGQHKKGDATKEDVSAVKNTVTSVKSALPIAPVSYEFSEIKKSDMPKAVEGGAYRKLRDARSEARYQGARDKRAKDKADEAAAAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCV1</accession>
    <name>A0A3D8RCV1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_07896</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RCV1"/>
    <dbReference type="OrthoDB" id="10592921at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025363">
        <property type="entry name" value="DUF4267"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14087">
        <property type="entry name" value="DUF4267"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW71862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="131" mass="13487" checksum="5C65EFD511C90921" modified="2019-01-16" version="1">MSTTATTIPFLVGTTYTLGILNTLIGLISIIFPGISGQLLGLPTSPHSANFSTTATFIAAKGARDIALGFCFVVFAATQNVDGIKTMIAASVLVGAVDATLIWRYGSTERAWLLGIGTAVLAGYLLLGCMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCX1</accession>
    <name>A0A3D8RCX1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_07854</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RCX1"/>
    <dbReference type="OrthoDB" id="10450858at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW71820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="200" mass="22901" checksum="6ADB0AC2FF33E623" modified="2019-01-16" version="1">MAPLVKAEPKDKPMSRIHVQSWKKAEVFGGIRKEDKHIKPRIILKMDNYYAKAAAFRELVEDERTTGLWSSKHAIYSWIQHPDAMTANYDMTTYSSYCKKYHAIYLEQREEGTTIAAQDGTAVSQSSHNEGEESNEKRYIIRIEGQKSPGYKILHKGAVVAVIPGKTKWRISSRIEDQDSFELLRVGLGRVDLFVRLSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RD92</accession>
    <name>A0A3D8RD92_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Origin recognition complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_08053</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">ORC is composed of six subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ORC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RD92"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000199">
        <property type="entry name" value="Origin recognition complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001025">
        <property type="entry name" value="BAH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043151">
        <property type="entry name" value="BAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054425">
        <property type="entry name" value="Cdc6_ORC1-like_ATPase_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048867">
        <property type="entry name" value="WHD_ORC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF23">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01426">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22606">
        <property type="entry name" value="Cdc6-ORC-like_ATPase_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21312">
        <property type="entry name" value="WHD_ORC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82061">
        <property type="entry name" value="BAH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51038">
        <property type="entry name" value="BAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BAH" evidence="12">
        <location>
            <begin position="100"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="253"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW72019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="763" mass="84689" checksum="144DC971AE4B98F2" modified="2019-01-16" version="1">MPHRTAASKSPDEQARKARETRRFLSGAAPTRNDSEAELEADDHQWQWVYREGYDQEGNAAEEDSDDDATAKSAAKSRRSSRHVTKQRSQNIVAARRAGCEYRLGDCVRLRAEGINETWVGIICNFDDDDPDEKAAAFMWFSSEKEIKPLNKYKKRTDFLENELYITPSTDPNPLESIIDKANIMSEKIFNENYPTGKVPKKSSDYGRTYICRRGCNLRTATYTDEFNWEELYQGGEAGKDSLLEWVKDATAKTTRKRRMQKQEDENGFDPEDEPETTVQTPRKRQKFLAATPTKTRSPSKLLTPSHRKVVIKKALEITPLGTRFLSPGHTQASPFQTARSKLHVSSVPTSLPCREDEFGSVYSHLEAAITDGSGACIYISGTPGTGKTATVREVVAQLNASVMADELDDFIFVEINGMKVTDPHQSYSLLWEALKGDRVSPTHALDLLEREFNHPSPRRVPCVVLMDELDQLVTKNQSVMYNFFNWPGLRHSRLIVLAVANTMDLPERTLSNKISSRLGLTRITFPGYTHEQLMKIIQSRLEGVPGNIVDPDAAQFASRKVAAVSGDARRALDICRRAVELAEAESLEAGIQPGTPSKTGKSKSVGQVTIATIKRAINEATTSPLQQYLRSLPFASKVLLAALLTKTRQTGLAESVMGDVLDKAKQMAKMDTGSNMIEHLLRDKADGTSKSKLSQQVGSKGAKIPRVLAMGTSAVDLMDAGIIGLEARRADRTGKVRLNIGEEDVRLAFKDDPDIKSLGFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDG9</accession>
    <name>A0A3D8RDG9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Isoleucine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BP5796_08002</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDG9"/>
    <dbReference type="OrthoDB" id="1706657at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004822">
        <property type="term" value="F:isoleucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006428">
        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07961">
        <property type="entry name" value="Anticodon_Ia_Ile_ABEc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00818">
        <property type="entry name" value="IleRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.740.10:FF:000044">
        <property type="entry name" value="Isoleucine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000004">
        <property type="entry name" value="Isoleucyl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000023">
        <property type="entry name" value="Isoleucyl-tRNA synthetase,cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000050">
        <property type="entry name" value="Isoleucyl-tRNA synthetase,cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.220.10:FF:000003">
        <property type="entry name" value="Methionine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02003">
        <property type="entry name" value="Ile_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033709">
        <property type="entry name" value="Anticodon_Ile_ABEc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19302">
        <property type="entry name" value="DUF5915"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 13 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="14">
        <location>
            <begin position="12"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="15">
        <location>
            <begin position="692"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00069879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDW71968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1080" mass="123978" checksum="979248879514BE18" modified="2019-01-16" version="1">MGSINFPEEEEKILKQWKEIKAFERQLELSAGRKEYVFYDGPPFATGLPHYGHLLASTIKDIIPRYWSMKGFHVERRFGWDTHGLPIEHEIDKKLGISGKDAVMKLGLANYNAECRAIVMRFSTEWRVTIDRLGRWIDFDNDYKTMDPTFMESAWWVFKQIFEKGAVYQGYRVMPYSTALTTALSNFEAGENYQDVNDPAVVVSFPLLEDSNTCLLAWTTTPWTLPSHTGLAAHPDFEYVKIHDEASGKNYILLEKLLTTLYKDPKKAKFKIVEKIKGRDMLGWQYEPLFDYFYEEFKDVGFRVLNAKYVTDDSGVGIVHQAPAFGEEDYNVALEAGIISEKRPPPNPVDERGLFTSRVRDFEGQHVKAADKAIIKYLKGTGRLVVESQIRHSYPMCPRSDTPLIYRAVPSWFIRIPEIVPQMLKNIEGSHWVPSFVKEKRFASWISNARDWNVSRNRYWGTPIPLWVSDDLEEKVCIGSIAELKELSGYTGDITDLHRDKIDGITIPSKMGKGQLKRIEEVFDCWFESGSMPYASQHYPFENKEKFERSFPGDFIAEGLDQTRGWFYTLLVLGTHLFGQSPFKNCVVNGIVLAEDGKKMSKRLKNYPRPDLVMDKYGSDALRLYLINSPVVRAEPLRFKEAGVKEVVAKVLLPLWNSYKFFEGQVALLKKIENVDYCFDPTAESSNTNVMDRWILASCQSLLKFVNEEMAAYRLYTVVPRLLDLIDNTTNWYIRFNRKRLKGELGLDDTKHALNTLFEVLFTLVRGLAPFTPFLTDNIYQRLLPHIPKDLQAEDPRSVHFLPFPDVREELFDAAIERRVGRMQRVIELARVSRERRTVGLKTPLKTLVVIHPDPTYLEDVRSLEGYITEELNIRDLILSSDEAKYNVQYSASADWPVLGKKLKKDVQKVKKALPGLTSDQVHQFVLSKEILVDGIKLEHGDLIVKRGLKEDASSKYLETNTDDDVLTILDAELYSELADEGLAREIINRVQRLRKKAGLQPTDDVKMEYRVLSDPDNIGLESAFKGQAKVLEKALRRPIDHHVVTAVEGKIPDGFEEGIILEEEAEIQKAICILRLLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDY6</accession>
    <name>A0A3D8RDY6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amine oxidase</fullName>
            <ecNumber evidence="6">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_08224</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:26414"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:58855"/>
            <dbReference type="ChEBI" id="CHEBI:65296"/>
            <dbReference type="EC" id="1.4.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="6"/>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDY6"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097621">
        <property type="term" value="F:monoamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00448">
        <property type="entry name" value="YjgF_YER057c_UK114_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.40">
        <property type="entry name" value="RutC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050703">
        <property type="entry name" value="Flavin_MAO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035959">
        <property type="entry name" value="RutC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006175">
        <property type="entry name" value="YjgF/YER057c/UK114"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563:SF14">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01042">
        <property type="entry name" value="Ribonuc_L-PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55298">
        <property type="entry name" value="YjgF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="7">
        <location>
            <begin position="156"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="176"/>
            <end position="177"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="379"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="486"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="577"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601613-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW72190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="611" mass="66137" checksum="19F0CD13CC14B488" modified="2019-01-16" version="1">MAPPTFQDTDSGFKPLYSDIASSQSSPGTIFISGQYGSTKTGSIPPSYEAQVHLALLNLRKCLLKANLTVKDILKLTVYIVDYTKTKRAHAPHLLTFLNGHRPAMTLVPVPELAKPEILFEIEAVASLPEPKGPVPTFSPELSQPILDVIVVGAGLSGLQAARTINKAGLSCIVLEARDRVGGKTWTKEMRKKKGHGVELGAAWINDTNQTTMWGLAKEFGLETVEQNTQGDCVLIDFEGERSTFPYGSLPEFSAAEKANAAEIRDKVESDCQEVDVFNPTSTKLDTMTFQDYVVSLGAGKAALANAATWTRAMLGVEPTELSALFFLNYCKSGGGLLQMRSDRKGGGQHLRLRKGTQGFSKALASVLPEGSVKLSTPVLAITELPGQNVTEVTTTYKTYLARKVIVSVPTPVYKTISFTPALPPAKTLLSESTKYGYYTKAIIAFKSSFWKSHNLCGLSQSFVGPASVIRDTSTEIDSSYTLTCFVAGIPGREWSLLPAEEKIDVLLKQVAKVYTPSNDLAFVREQFEDWIASEWLEDPYAGWGCPCASTAPGVLDATGSEPLREVVGNVHFVGTETAGEWKGYMEGAVRSGERGAIEVLNILKPAKAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIN4</accession>
    <name>A0A3D8RIN4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Acyl carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BP5796_07258</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Carrier of the growing fatty acid chain in fatty acid biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acyl carrier protein (ACP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIN4"/>
    <dbReference type="OrthoDB" id="448946at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099128">
        <property type="term" value="C:mitochondrial [2Fe-2S] assembly complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000035">
        <property type="term" value="F:acyl binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000036">
        <property type="term" value="F:acyl carrier activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.10:FF:000003">
        <property type="entry name" value="Acyl carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01217">
        <property type="entry name" value="Acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003231">
        <property type="entry name" value="ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00517">
        <property type="entry name" value="acyl_carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002148">
        <property type="entry name" value="PRK00982.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863">
        <property type="entry name" value="ACYL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20863:SF28">
        <property type="entry name" value="ACYL CARRIER PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="6 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Carrier" evidence="15">
        <location>
            <begin position="59"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDW73816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="138" mass="14982" checksum="2E0A3669EC8B688C" modified="2019-01-16" version="1">MFRTALLRSARSATAQIARRSGPIARQATPSSFVTKSQFAPSAFQAVRCYSAAAGLQKSEVEGRIVDLLKNFDKVSDPSKLSPTSHFSNDLGLDSLDTVEVVMAIEEEFSIEIPDKEADAIHSVDKAVEYILAQPDAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIU6</accession>
    <name>A0A3D8RIU6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SURF6-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_07256</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SURF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIU6"/>
    <dbReference type="OrthoDB" id="444809at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029190">
        <property type="entry name" value="Rrp14/SURF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029188">
        <property type="entry name" value="Rrp14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007019">
        <property type="entry name" value="SURF6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14369:SF0">
        <property type="entry name" value="SURFEIT LOCUS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15459">
        <property type="entry name" value="RRP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04935">
        <property type="entry name" value="SURF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA-processing protein 14 N-terminal" evidence="6">
        <location>
            <begin position="9"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal" evidence="5">
        <location>
            <begin position="299"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="34"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="283"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="376"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="427"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="132"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="159"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="179"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="225"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="297"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="342"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="430"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="442"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="454"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="475"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="489"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF15459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW73814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="57541" checksum="E5B06C85BE7012E4" modified="2019-01-16" version="1">MAESALHERLRDHSEAFDGLLSLIPAKYYYGEDNSDQWKKKKQTKEQAAAARKAKLDPDSAKSAKDVMDERARKRKLEEMGDESDIEGVEKEMPKQGLKLAQDKKAKKQKTADETETPTKTKSPATPQSKKTAAEAEAAKLAKAEQKAQKLQRKKEKQAKKTEEKKSRKEQVVTLPAENEAEDQATAEEEVVVEEEAAAEDDEDLPADEMANFEADGLEEEKVDSSNSSPPSPTFDTNVSAPSTNTSTSSVIPPGQAPKHIKIPSDPELLKARLAARIEALRAARKADGPDGAPARNRQELMEARRKKEEQRRAHKKELRNKARAEEDAKREAALASARDSPASSMMSPAIQSPEHNFSFGRVAFADGQTLTDDLSTVLDAPKKRGPQDPATALQASEKKRLRLAGLDDEKRADIEEKDLWLNAKKRAHGEKVRDDTSLLKKTLKRKEKQKQKSTKEWGERKEGVAKGQAMKQKKREENLQKRKDGSKKGKAKVKAVKGKTKVKSRPGFEGSFGGKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJ05</accession>
    <name>A0A3D8RJ05_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_07464</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJ05"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000037">
        <property type="entry name" value="alpha-1,2-Mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF103">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSIDASE MNL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="433"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="499"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="585"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="390"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW74022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="596" mass="68252" checksum="95261516D8FFF14B" modified="2019-01-16" version="1">MLTSRLSPLYPLTGITVMLLVYFYYSLDLEFTPGGSKPQQFTRPPVADGKFDWAKRVEKNPVASFIQMPMRGAVKIPRIQFRFQEDSVAAARETIAKRNEVKQAFKHAWSGYKNRAWLKDEVAPVSGISRSHFGNWAASLVDALDTLWIMDLRTEFEEAVEGVKNIDFTTTADIEINTFETNIRYLGGLLSAYDLSNGQYPVLLEKALELGDLLYAAFDTPNRMPITRWRWQRARDGEDQTAGYGVVLSEIGSFSLEFTRLSQLTGDPKFYDAIQRVTDMFAEQQQGTKLPGMLPLVGNAKEADFAADRTFSFGAMADSFYEYLPKQYLLLGGLSSQYRRMYEHAIDTAKDNLMFRPMSKENVDMLMTGNVYMKSPSGIELDPQGQHLTCFVGGMVGLGAKIFDRPDDIATARKLVNGCLWAHQSMPTGIMPETYRVVPCDNTTICEWDEKKWHTEVARWNNDFEATDSAMKKNKWLEENRVYPGFSAITDRRYILRPEAIESIFILYRITGDKKLQDDAWNMFRLIDTYTRAEFGHSALRDMTVVPPPKADSMESFWMAETLKYFYLIFSEPDLVSLDDWVFNTEAHPFKRPHFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJ27</accession>
    <name>A0A3D8RJ27_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_07495</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJ27"/>
    <dbReference type="OrthoDB" id="5125733at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW74053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="208" mass="22581" checksum="7A7B5978147D8247" modified="2019-01-16" version="1">MDRSESIAPIHAFYIEASLGLPYRLRTSVFGVPHPSEEPKSTPRSIWMSILVDYPERELSFPEDRLPAFSGMASELQTTSGDIYYAGVWQSCLLPRLVVASFHGPLHTTDVHEEDATFLEASTELVDEDSPLGNVHCGQVVLDARLFSKDTAKASNLTFNMDIGPDGIRAMDEKSKIGFLGGDDEDPVDKDGSGLILSPAGDGVLPAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RP58</accession>
    <name>A0A3D8RP58_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_06557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RP58"/>
    <dbReference type="OrthoDB" id="10292008at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW75736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="285" mass="33146" checksum="A583446624C5A8E7" modified="2019-01-16" version="1">MSFSTTSKRLLPDDNEVKSSINDDVTEYKGQMIIHVNKRERVSEGDDDLPIATNGQRDDNIILLQAVCHIGKLPSEVTQHIFKLAIGGPTAKSWAAGQVIEGFAPNRRLYLDAVQAYVTTNYFDLVRFKHEWRFHLCMDRFTRSQARKLRVFLDHNAPYNLNHMPVLVKKWHIHDFQKLQEVNFQVTATGWLEDSNTVKFLDRWVQCFTNLKRVEITIPITGYGPSAFAPWREHDQHKEIGIMRLNNITGVYGKLAWVPDETQSQGHDEIWFWQAPQDQYLRIPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RP59</accession>
    <name>A0A3D8RP59_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein BTN</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_06559</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Vacuole membrane</location>
            <topology evidence="8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the battenin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RP59"/>
    <dbReference type="OrthoDB" id="5965864at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003492">
        <property type="entry name" value="Battenin_disease_Cln3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018460">
        <property type="entry name" value="Battenin_disease_Cln3_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10981:SF0">
        <property type="entry name" value="BATTENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02487">
        <property type="entry name" value="CLN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015974">
        <property type="entry name" value="CLN3_BTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01315">
        <property type="entry name" value="BATTENIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW75738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="460" mass="49797" checksum="956BE3944114671C" modified="2019-01-16" version="1">MPTSPSAAARLPLPGSPGSSWAMYQARFKALFQGADASVLVAFWLFGLINNVLYVIILSAALDLVGPSIPKGVVLLADVLPSFGTKLVAPYFIHKISYSKRILIFCGLSSSGMLLVALTPTTQSVGVKLLGVILASLSSGGGELSFLGLTHYYGPFSLAAWGSGTGGAGLVGAGLYVLLTTTIGFSVKHSLLASAFLPVFMLVSFFIILPRAPLRKANMSKDYHDVPTTDIDSDDIDDLPTAAASSSLLAPGPSVAATAYSTTSRPSSPSRRSPNALFKANLRRARALFFPYMLPLLLVYIAEYTINQGVSPTLLFPLSSTPFSEYRSFYPFYNFLYQVGVFIARSSTPFYRIHNLYLPSIFQMGNLFLLISHSLYNWIPSVYFIFIIVFWEGLLGGAVYVNTFAEIMEKVPEGEREFSLGATSVSDSGGICIAGFVGMALEVWLCTWQVQHGRKFCKMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPE1</accession>
    <name>A0A3D8RPE1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S11-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_06696</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPE1"/>
    <dbReference type="OrthoDB" id="10254436at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00364">
        <property type="entry name" value="Ribosomal_uS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.1000:FF:000001">
        <property type="entry name" value="40S ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000266">
        <property type="entry name" value="Ribosomal_uS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028333">
        <property type="entry name" value="Ribosomal_uS17_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019979">
        <property type="entry name" value="Ribosomal_uS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032440">
        <property type="entry name" value="Ribosomal_uS17_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03630">
        <property type="entry name" value="uS17_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10744:SF9">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00366">
        <property type="entry name" value="Ribosomal_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16205">
        <property type="entry name" value="Ribosomal_S17_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00973">
        <property type="entry name" value="RIBOSOMALS17"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00056">
        <property type="entry name" value="RIBOSOMAL_S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS17 N-terminal" evidence="5">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW75875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="161" mass="18364" checksum="D3A8088DDB8AF501" modified="2019-01-16" version="1">MATELTVQSERAFQKQPHIFLNSKSKAKSSRVGKGGRRWYKDVGLGFRTPKTAIEGTYIDKKCPFTGLVSIRGRILTGTVVSTKMHRTLIIRREYLHFIPKYARYEKRHKNLAAHVSPAFRVEEGDQVTVGQCRPLSKTVRFNVLRVLPRTGKAVKAFSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPM0</accession>
    <name>A0A3D8RPM0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative phosphoribosyltransferase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_06572</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPM0"/>
    <dbReference type="OrthoDB" id="363185at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004689">
        <property type="entry name" value="PRK06031.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43218:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43218">
        <property type="entry name" value="PHOSPHORIBOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00156">
        <property type="entry name" value="Pribosyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="1">
        <location>
            <begin position="82"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW75751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="245" mass="27059" checksum="522DFCEA2EC418C8" modified="2019-01-16" version="1">MSDSLSEGSGHEHFTEPTTNYWQELLPQTSTQNQPPPWKYGVPVTLPDSQVLVLPIRQLKSSPEHGVASLLVNHASIEVVEVLGRMLGEKIKETVGDEEVMVVGLPTLGLSLAPIIAKAVGLKRYVPLGYSHKFWYSEKLSTSVSSITSPGLNQKRVYLDPYLLPLVRHKKIIIIDDAVSSGKTLKAVWDLLEDVAESEVVACGVAMKQGDVWRNVMGDERAEKCCWVFESPLLRAVNGGWDLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RQ61</accession>
    <name>A0A3D8RQ61_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_07024</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF28">
        <property type="entry name" value="SYNTHASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="65"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="951"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2428"/>
            <end position="2505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="7">
        <location>
            <begin position="951"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1094"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="7">
        <location>
            <position position="983"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="7">
        <location>
            <position position="1167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW76203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="2520" mass="275011" checksum="50FF238324A96828" modified="2019-01-16" version="1">MITTNGTAAGPNGLSVNGANGIPHQKDLNGAMNGATSSPAGGENVAINGYANGNAVNGDIKEKKFTPIAICGMACRLPGNIASPKEMWDFIVAGNDARSEVPATRWSTKAWYSATKKKGTSRTKHGYFLDETVDLGALDAAAFPMPRGEIERMDPQQRLLLEVAHECLDDSGEINWKGSSTGVFIGCFGQDWYDIQTRETLKYSNYQITGSHDFMVSERISHELDLHGPCLTIRTACSSSMIALNDACMAITKGDCKAAIVGGTSLHLSPATVTSLSEAGVFSPDGSSKTFSADANGFARGEGIVAIYIKSLDDAIRDGNAIRAVISGISTNFDGKTATMGRPYAPAQEANIRRAYEVAGISDIWRTGLFECHGTGTAAGDPVETEALAAVFSEKGIHISSLKPNLGHSEGAAGVSGVMKAVLALQNRTIPPNIKAWPLSPNIPFEKAKLLVASECMPWPAGRHERVSINSFGIAGANGHAIVDSAASYGIVHDSVTREEATPSLFVYSAYSSKSLGTITQNLQNFLETTSDSFADIAYTLGRKRRHLPYRSFMVATKSRPGNTAPAFTPEQDPIHSLVMVFTGQGTQWPQMGRDLIRSNKAFAEIIKTIDMELQFLGANWTIEDELRKNSRSTKVNDAEFSQPLCTVIQLALVEALAAVGVRPAAVVGHSSGEIAAAYAAGALNLREAIAVAFHRGKISKLQTKRGAMAAVSMSWEEAHKYLVPGVVVACDNAHNSVTLSGDADEVASVTAKIKEARPETLTTMLKVDRAYHSYHMVEVGSDYYEALVACGVVGAPHVVPFFSSVSGQQLGNPDKQGQLGPRYWQQNLELPVRFKSALVGILKHPAIVNPVFLEVGPHAALEGPIRQILANESRKAPQVSTLVRRQNGTESLLVAIGKLWALHINVDLSTLMPTGRTLNDLPSYPWDHGKSHWYESRVCREWRLHGHACHDLLGRRLPESTDMEPIWRNLLHLENVPWLYDHRIENDIIFPASAFMAIAIEAVRQLGEAPQAVDLRNVAVRKALPISEDSPTELVTALRHCRLTDSLDSEWWEFTISSHNGNLWTRHCTGQVRAGSGHLASVKPVPFAASQLPRKVDSGKWYEAVQRKQLSYGPHFTSMEKITASVTKTLSGQEDCTRRISKASATLRNNWHGDEENYFMHPVIIDSLFQLLSTAVYDGQSHIYRRLVPTGVDYMAISPCSSDNVQIFMAGDLSNDGAASGYGQCIGDSKVIADCSGISLVLFEGADLRAENDFPLTSRSEWVRHIGFGDIGARFETLSTNADAEDSQIFQDLVDLAIRYSQQVAYDVEPQAPHLQAYKTWLDTQATTSPRQTQALKTADEIQSMALRLKASSLATEAKAVASVCASIVPILAGIQNAYEVLGIDGLLERVNRSMVEYAGSKFFHEFGLFKPNMRVLELGAGSGAATAKILQYLRHEKGQNLFSRYVLADASTGLLDIARKRFKETKDLEFACLDIERDLFNQDFEHEEFDLIIATGVLSSTKKIAHGISNIQKLLSSKGRVLVQEPRPGSTWAKFVLGILPSWWSGHADERAAEPFINQERLEKELCTAGLGSFRVLNGDKSTIVVAQATGEQPISPKVTVLCEQQTLEIEAICYGLEARGYDVARYTLNDAPTTNNQNIIALLDLTEPFAWNLTEARLNSFQRFVMGLQKSGVLWVTRQSQAGVIDPRYSTMIGLARTMRTELAANFATCEVDDLVNRANADALIQVFCDFQDRRYDGALGPEYEYAISDGAILVNRFFPFELETEIRQSLPAPEASLAIAKVGQPGTLYWSAQPSVAPRSGEIEVQVHTTGLNFRDVLVATGILQLPETHFGYEAAGIVTKLGPTATKFSVGDRVMLVGHKTFASSVVQSEMLCEKIPDSLDMLQAAASPLVYLTAIHGLLDMGRLDEGQSVLIHSAAGGVGIAAIQVAKMLKANIYATVSSEEKRKFLAEKLGIPSENIFDSRSTAFAMEVMSKTGGKGVDVALNSLSGELLHATWTCIAKWGTMVEIGKRDLMGSAKLDMRPFSDSRNYCSLDIDQMAKERPKLIEKLLRRLKIYFQQDQLQPIPVAQIFFPSRAGEAIRCMQRGQHIGKIVMNLRDSDKNVLFNQVELPQKRLSRFDGSAAYLLVGGFGGLGRSTARYMVQQGACNLIFLSPTSDRNHPQHKEYIREIEAMGATIHCVQGSVAEAADVERAIDGAQAPIKGILNLALGLADNAFQRMTFNEWDSAVTPKIKGTWNIFEIVKSRQLQLDFFLIISSLSGIVGQTGQANYSSANTFIDAFSQYSTNQGVPCTAITSGVMEDIGMMSNNAEILRRLKGSGWRLNNEIELLEAVDSAIQLCSQRTETPASYSPMAIDKTRFVFGLCPAVPLSRPDSYTNLRADSRMAVYHNSKRQSNNSGGAEDSSLRTLLGTAKKNPSILESDASINHLAMEIGKKLCSLLLLPEDQLNTSMRTADMGLDSMVAVELGAWWKVTFGIELRTLEVVNIGTLQGLGKQAAVDLIRLYSEPTRIYKSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RQH5</accession>
    <name>A0A3D8RQH5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">UBC core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_06955</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RQH5"/>
    <dbReference type="OrthoDB" id="47801at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043066">
        <property type="term" value="P:negative regulation of apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116">
        <property type="entry name" value="(E3-INDEPENDENT) E2 UBIQUITIN-CONJUGATING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46116:SF39">
        <property type="entry name" value="BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="4">
        <location>
            <begin position="458"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="700"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="155"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW76134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="828" mass="91482" checksum="B8B338E9DFBAFF13" modified="2019-01-16" version="1">MKRALRLFCFTPSGSPSTTLRKRQKSQARMNSLEETLNMDLESALSRARISEETDCWDLHVNMSQLASFYESFSAKGACVGCGSKLDFRSAIESEQMGLGCTKCEVPICICCGKKLQTELGLPRICCEAGRLYSIWAALAKFDATDLKFRNQAAEKRKLRKDDSQRNKIPKWYTGSGSSPNSGVGYGGGLDFEDFESAFNDLSDAEKALWAAKYGPPQPLEDQAPPRPKSPKLDYQEDTLISSTLRHITALLVNPKKGPISFRPEELFLFRLSFLLDRVCDLLRNDSIVDITNRSDTYRQAFVFTAKIANCPELSTLIYEQRAQKKDSPGILDLSQSSTSSSASNVETVSSATLPSLFSCCKDTYTQAKALLELADRKISKRGKKRLIENDESLSVCQNVIDLYNLLSSKAPVQVSKLSKDPWLEFCESNRVTFTEDVLTPHKYHSLFTRSKFTTKSGRMATIGKEIATMTTSLPPGIFLKVAESRSDVMKILIVGGDDSPYSGGLFEFDMFLDGNYPLSPPLVTFTLYEGEDGGGFHGFNPNLHMGGSVCLSILNTWDGAPSQKWQPNKSTMLAVLISIQAMILGAPFPYKNEPGFENAKDSDPKVVSNRNHVQLKTVWYAMAHWLQDETVKTSVWADISKTYWNLNADIVLATVTSWGVTNASLTNLGGPSKPMHGYPRGKDESMIQLLCRLVATHNQTSESVSDGESGGSDDNGKSKRKSSLADDTESEKRRRLNHGSGTSSKTHSSHKWVYTGARTQTEVLNARIKFGVKPGHTIADSIAKLEAAVNAGKIGPNLANEFGEWREVLKGDDSNDEDEDQDFDMIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RQJ4</accession>
    <name>A0A3D8RQJ4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Elongation factor EF-1 gamma subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_06975</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RQJ4"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03044">
        <property type="entry name" value="GST_N_EF1Bgamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000142">
        <property type="entry name" value="Elongation factor 1 gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050802">
        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF1">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="3">
        <location>
            <begin position="2"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="4">
        <location>
            <begin position="93"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW76154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="229" mass="25836" checksum="92220F7D81C692A4" modified="2019-01-16" version="1">MSFGKLYTYPKAPRSTMTLYIVEHNKLDVEIVTALPGKVYLDHDGVGEVYFSKFHTGKVPAFETADGFCVYESIAVSWFLAKQDPQTTLCGSNLREETTVLRWASFTNYELLPPIMAWINPIIGRSTASPEKLLELEDNCELTVRAVEKEITGKKFLVGDTLTMADLFVISGLARGYQFVFTKPWAAKHPIVHEYYMRIRSDPIFVKIAGEPVVRDEPGGTYPDYDGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVC5</accession>
    <name>A0A3D8RVC5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8004 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_05778</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW77926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVC5"/>
    <dbReference type="OrthoDB" id="5300331at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058317">
        <property type="entry name" value="DUF8004"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39601">
        <property type="entry name" value="CHORIOGENIN HMINOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39601:SF2">
        <property type="entry name" value="CHORIOGENIN HMINOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26013">
        <property type="entry name" value="DUF8004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8004" evidence="2">
        <location>
            <begin position="403"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="266"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="814"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="897"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="920"/>
            <end position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW77926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="967" mass="106208" checksum="E31FC2835AE29AEB" modified="2019-01-16" version="1">MSKRDSLLGRKSTRLQRLSAYLPNLNTSESKRSQAPPLPARKALPERSRRPSESPSPPLPPLPSSAPADLTEHASKLQKPTPPARSPPRLPADANGSSPNSITPGRLTKVRPQSPNASPRGSPSVRAAGRRGSLVPPPVFNDMLGGRTVSAPVASEEANKLSRRSWMPGGKSRNTSQNTNTHNHSPAPPAWIIAGEHKIDYGLTSLTHGEKIPELWDEDKGDTFVYLFPRSSGCGASFKVSSMLLSSSQPLLNLIHGDIYAGRPRAASPSGRTWPLDEAAPNPSLRGPGTPPYTPKTNPLDNISNSDGSADSMTSLSDPPREIHLYFPGILILPAATGQELPPEDIQSLIGVRNLFAFLTGQPLVATRECHSLYRIFMAIAALLKQFDFTNFDGSTYGEAADASFRFFMHELKLADVTHSREKTLEALVLGERMRSMELYTEAFAHAAGKYASIMSIKSPLYEELSVHTRHRLERASLDLRQRQQAAEIRLTDFEFPSMFSGIGNSTSRPEARAVNFKSWKANFLAFRKALLSHYKHLHGQWPPKASSKKNQFEENGLNRLVLKGLYKDLSDLYDLLANREALTTRHYDASDDAEVTNIEPTITVLRTVLGEYDRSSPPVQPPIPFDVPRIPTMASINPTYPSLSPKDQHKMSTRKLKSHEMLLLLAKSHNLDCDYKTPFLEMYKAFEEKEAKGKNSQELADQRYGHWLFLYAVIQSLPMLVVDVPGLHYTSGAEYFLCEPPLGNAPWMDEASVKMAWYGVQGGAGVVSLPSDVVVHGVEGIYRRSHCWTVAEKWISEGEQEALSAPAALTEDFGGILSPLEPPPGFGEAGSRPSSRGRDRSDSQGSLSPYASDNERRSRSRTSYRASQRNSIALGLEQLPIPSGMGASTEYRPNMGSRHGSASRGASPGPGMMGHGQMRSISRSRGDSPTTEANRGSTFDDILGTSLKAPVERKERRKSFISFGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVH2</accession>
    <name>A0A3D8RVH2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mitochondrial intermediate peptidase</fullName>
            <ecNumber evidence="4">3.4.24.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Octapeptidyl aminopeptidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BP5796_05905</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.</text>
            <dbReference type="EC" id="3.4.24.59"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="15">Binds 1 zinc ion.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.59" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVH2"/>
    <dbReference type="OrthoDB" id="17530at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06457">
        <property type="entry name" value="M3A_MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033851">
        <property type="entry name" value="M3A_MIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF79">
        <property type="entry name" value="MITOCHONDRIAL INTERMEDIATE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="9 15" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="16">
        <location>
            <begin position="299"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDW78053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="801" mass="89077" checksum="3D5243C53368031E" modified="2019-01-16" version="1">MSLLGRAPGARIAITRIGDLSRISTTCAGPKFQRYLASAASRLYEPRPTPVDNSPPGAIHDDRVLRQIFDSSDLWREFSQSSKYGPGRKSLGLVQNRYLTDAQGFEDFVNTSLANAKRVVDKVMGASSVEDYKSIVQDLDRLSDLLCRVIDLCDFIRATHPDAKIHNAATEAYSKMFEYMNVLNTTPGLNDQLTIALRTPEVVASWNEQEVKVADILKRDFGRSAINLPQAQRDRFVALSQEISELGNAFSNHMGPAKQQLTFDSSKLTGVDPVIARNLTSRWGKISLPTVGGYTSLALKTVQNEDARREIFMASRTSSQASLGLLDALLRKRLELANLTGYESWGHVALEDKMAKSPESVSQFLQALSRDNKPIVEAELADMVTAKTKNPKAFNAPLQPWDREFYQAQILSSIRSRSRTPDFLAAYFSLGTVIQGISRVATRLYGIRFVPRETTPGETWNHDVRRLDIMSESDGHIGVLYCDLFSRPGKSPNPAHFTLRCSREISEDEVAEAAAFHNPRFTPSEEAANDGMATSTTSGKLMQLPTIALICDFEHLHKNANTPTLLSFGEVLTVFHEMGHALHSFIGRTSLQNVSGTRCATDFAELPSILMESFVSNPAALGLFARHYETDQPLPYHMIADRLALDKRFEGTDIENQILLSMVDQEYHTTAPQRSSFDTTQIYLDIQRSYGVLPADPPGTSWQGMFGHLFGYGSTYYSYLFDRVLAKQIWKILFASGEGAATIDRRNGEKMKESVLKWGGGRDAWKCLADVLDDPRVENGDKNAMAVVGSWGVKQRQGLIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RW20</accession>
    <name>A0A3D8RW20_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative APC1-subunit of anaphase-promoting complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_06050</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26401at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000400">
        <property type="entry name" value="20S cyclosome subunit (APC1/BimE), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000283">
        <property type="entry name" value="Anaphase-promoting complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000531">
        <property type="entry name" value="Negative regulator of mitosis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024990">
        <property type="entry name" value="Apc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048971">
        <property type="entry name" value="Apc1_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046794">
        <property type="entry name" value="Apc1_MidN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049255">
        <property type="entry name" value="Apc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827">
        <property type="entry name" value="MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12859">
        <property type="entry name" value="ANAPC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21282">
        <property type="entry name" value="APC1_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20518">
        <property type="entry name" value="Apc1_MidN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 N-terminal" evidence="7">
        <location>
            <begin position="32"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 middle" evidence="8">
        <location>
            <begin position="1068"/>
            <end position="1118"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 1 beta-sandwich" evidence="9">
        <location>
            <begin position="1742"/>
            <end position="1821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="414"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="794"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="824"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF21282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW78198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1951" mass="216255" checksum="249C0E999991EEFB" modified="2019-01-16" version="1">MASVTSLGLHQPTGLQYALQERLLPVDPAKGSYVWHNDCDHVTAHTVEDDELLVTPRCVVWSRGGLFRKSYKFDLEKEEVSQALLTWFPNVKSIPGTGRRGGRLSTETSSRSKAIVVLLKTQAHIYFLSGTSHVIHLPFEVESAVAAPNGLIIQRKLRVDNLAAASLKFPRVPPNSFVSSQPQTFSATSSQQSTFSIADLGAPKQMPLPPVSTLKDMWDPPALTNDSNWPRLFSLTDPLSEMGLIVTQLSKQERRNHKTNTKKLQHLDTAEEIIHVTKSHEFAHKDDDQPLILALTLNRETSMYTVWKLLYVGKDAGKKGKARAVSGTFSRRRSSFVPGTGTGATTPAMNAQHTFRESFGGEPNMLRSKQVSAHENELRDDLASTLDPDYESTNVPRRKSRRVSSMLARADLSASHERSAFNELTGNNAPNKRGESLGSQYTRGSIGTYGHAGGNLPGFSQSQQFSHSINSLLEAPVDDLLDELRAGGDFEGFHNMGLDDEEFDALKQEIILTKITSVPAEHSNVRYSSQHIPAKGQCKVFTMAAPPSAADDQQKNTIVICILDPDEKRLLVLTLYTKVHKKEHLDGSSHGSETKKAEKQVTVVSLGDVMRAKGVIDACRLDDGSVSRILVLTDTSDGFGELTLQAPWSALMKIPLPEKFAISGIRSLEQDSVPRARREGSLKRVLSQGPRALKGLRNSKPFGIVDLIDDDDKLHQLRILMQPRNPHVRRILEVGRAVLPGPVRGGEGILVGWWNVMQWLRLEDVETVDTEWSAAVITLFTLVLATDDAAKAGQPRLQTRQRKVRSGLLRSSSGAQSDHESWEMMQSQETFNGNPVPSWANNGGWSWIADQDEFDQTATIGNGQVFNVVPDDKGRFLQKHVRLTLDFMDSALGQAAVSGYLPTSDSGNRPADARVAAVTDVIVALHLFREEQKLDTMAADALATGVGSLTPVLAQICRWLNWKNWTEVYDVEDVCLAGIEYDTRPMHLHIPEPYDCPTIYQWVQTCLLTKSLAPFLTLAELAASQSSASSKSIWDLEQWEDLTPRTLLFVKFFASMKPNWTPVQFVEALSSAGISVDFLETLPEAILLPLREAIVQCRKEPPTTWNKELLTLVGREDVNTLLTPGHQPRQNNTTLLAPSHESNLDVHSICASIADVETTGSFDGSAEFDRQSITRAIFKDDRRMNEARNILNTIKPTVARVKTEPSWSESDILEAQKEHVQMLAYRTLAIPAGRGLLYFSARIPLLTQRFNISGFNLNCVMKPDNNTVGVDKNAFTEEKVCWAFFHAGVAAGLSISRDAKGIDTSWILYNKPIQELSNRHAGFLLALGLNGHLKSVAKWVAFKYLTPKHTMTSIGLLLGLAASYIGTMDSLITRLLSVHVTRMLPPGAAELNLSPLTQTTGIMGIGLLYCNTQHRRMSEIMVSEIEHIDTEVDEEPLRNEGYRLAAGFALGLINLGKGSDLKGLHDMGLTERLLALAAGSKKVDLVHVLDKATAAAVVAIALIFMKSEDKVLARKIDVPDSILQFDFVRPDIFLLRTLAKHLIMWSKIEPTLEWVERNLPQPYRERSKLDNVTKLTSEDLPFYDIVTGLCFAVALRYAGSGSVPARDLLIHYLDQLVRICQIPTDTFDKKLTRNTIRNCQDLLALAVATVMAGTGDIIVFRRLRAMHGRDDGLETPYGSHLAAHLAIGALFLGGGTHTFGTSNLAIAALLIAFYPIFPSSVQDNKSHLQAFRHFWVLAAEPRCMVTKDIDTNQPVAVPIVITPRIGESIDRHTPCLLPELDQISNVQTKSSEHWNVVVDLQHNETHIASFKATQTIYVRRRPVHETNTSTFQATLQALNETHDSSPQSLEWLFELESFASLTQAERALVLPADNGGATDIRAGTDSTVVDARLVLERATLDSGKRDRLLGLKLLFEWADMARSEGREMQWIKREAIERLKGKVWMAQEQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RW84</accession>
    <name>A0A3D8RW84_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">NADH-ubiquinone oxidoreductase-like protein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_05956</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the complex I 49 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RW84"/>
    <dbReference type="OrthoDB" id="1009at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006120">
        <property type="term" value="P:mitochondrial electron transport, NADH to ubiquinone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.645.10:FF:000005">
        <property type="entry name" value="NADH-quinone oxidoreductase subunit D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.645.10">
        <property type="entry name" value="Cytochrome-c3 Hydrogenase, chain B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01358">
        <property type="entry name" value="NDH1_NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001135">
        <property type="entry name" value="NADH_Q_OxRdtase_suD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014029">
        <property type="entry name" value="NADH_UbQ_OxRdtase_49kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022885">
        <property type="entry name" value="NDH1_su_D/H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029014">
        <property type="entry name" value="NiFe-Hase_large"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01962">
        <property type="entry name" value="NuoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004739">
        <property type="entry name" value="PRK06075.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993:SF10">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] IRON-SULFUR PROTEIN 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11993">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 49 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00346">
        <property type="entry name" value="Complex1_49kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56762">
        <property type="entry name" value="HydB/Nqo4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00535">
        <property type="entry name" value="COMPLEX1_49K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0520">NAD</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <keyword evidence="8" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="NADH-quinone oxidoreductase subunit D" evidence="7">
        <location>
            <begin position="206"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="55"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW78104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="476" mass="53616" checksum="18100F643B0C3FA2" modified="2019-01-16" version="1">MAASITRLAGRSAKRLCLQTSISRSSLPRTSLRAFSAAVPWKYAQPYEGTRLIPTDAAFSHPTNPDDPQHINVTPDSNLHDGENVENRKIRHYTVNFGPQHPAAHGVLRLILELNGEEIVRSDPHVGLLHRGTEKLIEYKTYLQALPYFDRLDYVSMMTNEQCFSLAVEKLLNVEIPERAKWIRTLFGEITRILNHLMSVLSHAMDVGALTPFLWGFEEREKLMEFYERVSGARLHAAYIRPGGVHQDIPVGLLDDIYQWATQFGDRIDETEELLTDNRIWIGRTKGVGVVSAADALNYSFTGVMLRGSGVPWDVRKSQPYDAYDQVDFDVPVGVNGDCYDRYLCRMEEFRQSLRIIHQCLNKMPAGPIRVEDYKISPPPKAAMKENMEALIHHFLLFTKGYTVPPGETYSAIEAPKGEMGVFVVSDGSERPYRCKIRAPGFAHLGGFDQISRGHLLADAVAIIGTMDLVFGEVDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3J5</accession>
    <name>A0A3D8S3J5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein BCP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_05438</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 3">Involved in nuclear export, actin cytoskeleton organization and vesicular transport.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the BCP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3J5"/>
    <dbReference type="OrthoDB" id="27543at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025602">
        <property type="entry name" value="BCP1_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261">
        <property type="entry name" value="BRCA2 AND CDKN1A INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261:SF0">
        <property type="entry name" value="BRCA2 AND CDKN1A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13862">
        <property type="entry name" value="BCCIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028983">
        <property type="entry name" value="BCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW80740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="285" mass="31981" checksum="8A388BA8B70F9D00" modified="2019-01-16" version="1">MVKKRTRDPEVLPEAPEIENDSDDDMDVVNVDFEWFNFKPDIDFYGIKALVRQLLDVDHQLFNMSEVADLILSQPTIGSTVKVDGEDTDAYAFLTILNLHEHREKPVVKDLTKYISEKAKSNPSLAPLSELLSSNAQVGLVLAERLINVPTEIAPPMYTMLIDEIEAAVEDKEPYEFTHYLIISKTYREIASALDQEDAPRQKKNKATKGSSETFYFHPEDEVLQRHALAAGSYDYTRDEGEGMADSKRAFQDMGIKPQGSMILIEASKFEGAVKAVGEYLGAAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3R2</accession>
    <name>A0A3D8S3R2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">T-complex protein 1 subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">CCT-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_05429</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3R2"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03335">
        <property type="entry name" value="TCP1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000005">
        <property type="entry name" value="T-complex protein 1 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000009">
        <property type="entry name" value="T-complex protein 1 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000070">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012715">
        <property type="entry name" value="Chap_CCT_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02340">
        <property type="entry name" value="chap_CCT_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW80731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="568" mass="61737" checksum="855FD999B787F997" modified="2019-01-16" version="1">MGSLFEQPRNAGTLFLGGTKISGSDIRDQNVLATQAIANVVKSSFGPSGLDKMMVDDIGDVTVTNDGATILSLLDIEHPAGKILVDLAQQQDKEVGDGTTSVVIIAAELLRRANELVKNRIHPTTIITGYRLALREAVKYMHENISVKVDTLGRESLINIAKTSMSSKIIGSDSDFFANMVVDAMQAVKSTNNRQETKYPVKAVNILKAHGKGALESILVKGYALNCTVASQAMVTRVTDAKIAVLDMNLQKERMKLGVHITIDDPQQLEQIRQRESGMVMDRVEMILKAGANVIMTTKGIDDLVLKLFIEKGAMAVRRCKKEDLRRIAKATGATLVSSLSDLNGDEKFDASSLGHAEEVIQERISDDECILVKGTKVHTSASIILRGANDYQLDEMERSVHDSLCAVKRTLESGSIVPGGGAVETALHIYLEEFAGTVGSREQLAIGEFAQALLVIPKTLAVNAAKDSSELVAQLRSRHALSQRIQEGDANENEKTIAKKKNYKNYGLDLTKGKVVDEIKAGVLEPSMSKIKQLKSAVEACISIMRIDTLIRLDPEQRGEQDDGHGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S406</accession>
    <name>A0A3D8S406_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_05502</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S406"/>
    <dbReference type="OrthoDB" id="3490312at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF4">
        <property type="entry name" value="HYPOTHETICAL CONSERVED PROTEIN (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW80804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="20474" checksum="E8AAF765994F68BE" modified="2019-01-16" version="1">MGLRTQPFENEDEFQYFTLFRDKTALEISPYFKTQTWRKLVLQAASLPSIRHAAIAIGALDKVSTLLLQRSSLPADGEKSDPDFHHHFAVQQYSRAINRMKGDATAGNQDLRTTLITSLVIIWFESYHGNRKLAQAQIQNALRMIRAWKESFRDSEVEAPLGFSSPQPGVVEHDLVRIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S9R5</accession>
    <name>A0A3D8S9R5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GPI anchored protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S9R5"/>
    <dbReference type="OrthoDB" id="10435508at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017656818" description="GPI anchored protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW83085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="183" mass="18037" checksum="1DABA88A411A0A17" modified="2019-01-16" version="1">MRVPTILLGLTALMMPALGAVHGTSTIESSITSDTSSATRSTSTPTTFTTATSAADLVSAQTQTPSFPMSNSTAVATSTLSAGVSLTTTFANTSATAIQSFSNSTMTAISTSMAETDALLTASGSPTMNTVTSMVIITPTGVITASGSAASASASASAASQQQYGSSLALGLLTLGATLLYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S9W9</accession>
    <name>A0A3D8S9W9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Cyclic peptide transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BP5796_04422</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW82931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000055">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000066">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001854">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF269">
        <property type="entry name" value="ABC MULTIDRUG TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="265"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="406"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="918"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="961"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1029"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1140"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="275"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="624"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="922"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1235"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="860"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDW82931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1469" mass="162510" checksum="0BF2CFC6CE5AE329" modified="2019-01-16" version="1">MSLNSTNFEEHSFSLSAIGHFDFSPLFENSILSILPSSLLFLVLPFRLWALRKEPPKISKTPSILYSNKLAFLAVYIALQAALLVLYAANSSVRTPSSLTAAVLAVLDALGLLLLSHAEHFRSLRPSDITNTYLFITLLFDIARTRTLWIQHAPKPIAAVFSAMLAVKLSVAITEAVEKRGILLLPYRHVSPEATSGIYSRAFFWWLNKIMMVGFRRVIRDEDLFPLEDDLSSIVLKRQAETSWARANKTRSHALFWSTLNANRVKLAASMFPRLALIGFRYVQPFLLSQTVDFVGRKEESDSIGWGLTGAFLVVFLGIAIASAIYSHTCYRFVTAVRGTLVSMIYAKTVDLSITALNESAAITLMSSDTVMAKKESICSSFQNLHEIWAVPVELGIALWLLQRQIGLSLLAPAAVALLSAVGTMWISNYIGSAQKIWNEGIQTRVDVSTSMLGSMKAVKFLGFTPTIINIVQGLRVKELQLSFVFRRLLVAGAFFSNNMRLLAPLITVLLFVPFEGALGRELTASSAFTTLSLIAMLDGPVGTLLRTIPNLKAGLACFDRIQSFLESDSRRFHVLPLNAASNLSNLNFNEDPVAITDVDVHPNMSFELQEFEVQLPHPSKVLIDVRNASFGWSLSGPPQINDVTFSVAQGSFVFIIGPVGCGKSTLLKGLMSETPSLKGFVYSNSLESAFADQSPWIQNTSIRDNIIGTAIFNESWYNEVIEACALQYDIAALPDSHDTIVGSRGISLSGGQKQRVALARSLYSKKELIIIDDGFSGLDAETEEQVFVRFFGQQGLLRKLRTTVLLVTHGVTRLSYADQIIALDANGHIIEQGTFQQLQHAGGYVEGLAIKHKFESTSARTVSREESKNTAAQPALSTEAVKARTKANAEEDDLKRPIGELSMYRYYFSSIGWSKTLLWLFFTILSGVAAKLTELVVTYWTNALSSHGIEVNGVYMGLYGMLTGIGTIFWVVACYQFFLYLVPVSAETLHARLLNTVMNAPLQFFTSTDTGITTNRFSQDMSIVDNDLPFALIDLIVAVVQAVIGAILMCFVAGYFALTLPPVAFAVWVIQKYYLRTSRQVRILDLEAKSPLYSHFIESLSGLVTIRAFNWSDVFVEQNLLLLDNSQKPYYLLWCIQRWLSLVLDLLVTVLAIIMMVLVVILRNSVDSGFVGLAILNVINFSQSLAWIIRQWTSLETSLGAISRLKNFTLNTPNENLAGEDQPVAESWPEHGGIEIKNLVVSYTITGPPVLKGFDMSINPGEKIGICGRTGSGKSSLIMTLFRLLETSSESSILVDGVDVTKIARQAVRSRFNAIPQDPFFMKGNIRLNASPENIHSDAEIILALTKVDLWTIIEARGGLNAQLDVDFFSHGQRQLFCLARAILRKSNLVVLDEASSNIDVTTDKLVQRVIREEFKHATIISVAHRLNTILDFDRVALLDNGELIEFDSPQALLGHPSAFKELYSSSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAJ8</accession>
    <name>A0A3D8SAJ8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_04817</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAJ8"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045719">
        <property type="term" value="P:negative regulation of glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14004">
        <property type="entry name" value="STKc_PASK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000320">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000314">
        <property type="entry name" value="Serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057213">
        <property type="entry name" value="DUF7891"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF51">
        <property type="entry name" value="PAS DOMAIN-CONTAINING SERINE_THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25421">
        <property type="entry name" value="DUF7891"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="945"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="86"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="239"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="460"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="504"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="856"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="277"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="304"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="473"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="504"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="859"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="914"/>
            <end position="937"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW83326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1210" mass="132832" checksum="87F13CA0A5ED84A2" modified="2019-01-16" version="1">MLEPDGTNNHGQLASIPSEEPPFLSVETQARGRRPHPEDIVLPKTRSSNNLYAHGSNGTDRARIRFSFDAGLAPAELDSISRSNVMTEHEHGLGGPSGLRRIRQQPRAPTIPSESSSRAASIGPRSSSMTLPVSTSRAASIIGPSGPSSPTLNFTEDLSRFPSESLHSFSFAHQSDEFIHNRQNVLKRSVEFMSQKLGWGSAGIASAQARLSGDQEMQSMLELLARANLVGADNIAGHSQRSAYGPLTGPPTAEDIDNPFENSFIPRPGSPPIHESPQASPKMTKRLVSSKQDLEDVGPKNEALLTSNIDGDSEASSRTPTDESHTTAKTSPPVTRRPSVRRTMTDTAPLSLQNKLMDALAQPYVANDLLYDNLLSPGLPPAITPATLTGSHPLGSAVHGHSSRWAPAAQAIFTTEGCSPYTILAANDLACLVFGVTKAEVRKMGILEVVREERRAWLEEKLGSPGTSETGKNSRSSQSHSNQPSPTPTTSFLLGRSGITASLLSKPNSRQTSKTMPNRRAQSDDGAGSSIVARKKAAARDGYHHPSNKSRGVLLCGDVVPIQKRNGSVGSASLWVKEKRGGLIWVLEEIHEDVATIQLDDDAVITKISGSTEPIWGENAVQVGMDIGKLIPQLPRQGLDGRSGEIDYAEVSKRKYFTARNAARVNIPTMVERVQDCTDLRISSFPHIAGIMVLSSKTLEITSSNSVFSAALFGQEKPDGRPITDLIPGFDRMLKVLTEEDGVQLQDGLVIPEHSFRRARAFLALRDGKADAASYFLRPDGLPAKHRDGSEIKIDAQLRVVQSETPVYDEDVIEERSDEEDEIRSEAAPQSELVYALWITYSRHLHAAKGDPGVLSLMASGSETPLRQPSPGQKDEIATPMDMDSDTSTKEPSHASLLTTQLKAVAKKTAAKLTGRDPEPKHEESTDAKGSEVVEPTEKKSIDDFVILEEMGQGAYGQVKLVRYKKNGNKKMVLKYVTKRRILVDTWTRDRRLGTVPLEIHVLDYLRRDGLKHPNIVEMADFFEDDVNYYIEMVPHGLPGMDLFDYIELRVNMEENECRSIFVQVARAIHHLHTKALVVHRDIKDENVVLDGEGNIKLIDFGSAAYIKNGPFDVFVGTIDYAAPEVLAGKPYRGKEQDVWALGILLYTIVYKENPFYSIDEIMDRDLRVPYVMSDNSIDLIRAMLDRDVESRIDIEGVLAHPWCQMEEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SBQ4</accession>
    <name>A0A3D8SBQ4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_05015</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SBQ4"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051911">
        <property type="entry name" value="SDR_oxidoreductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43976:SF16">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW83524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="310" mass="33584" checksum="5E1DAB423E1F2C4C" modified="2019-01-16" version="1">MDQSNARSYQLPSNAVWFITGCSSGIGQALAEFIATETPNRLVATARNASALSYLPDRPDILKLALDVTSTQSVDAAVGAAVDHFGRLDVVVNNAGYGMSSDTEAVPDDAARRLVETDFWGTVRVMKHALRVMREENVKNGQQGGVVMNVTSMGGFMGFPGNAFYHASKFAVEGFTESVAKEVNPDWNIHFAIIEPGAVQTNFAATILGQPAIHPAYASPSMPTRMIEAYVKDPKMHESWALPTVVAGCMYEVVSKGGQIRLRTPLGADAWGMAMLELEHLKKEFEEAKDIANKVSCPAQLEAIDFLKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SG91</accession>
    <name>A0A3D8SG91_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">dihydroxy-acid dehydratase</fullName>
            <ecNumber evidence="14">4.2.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BP5796_03694</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(2R)-2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:24809"/>
            <dbReference type="ChEBI" id="CHEBI:11851"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:49072"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:24810"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(2R,3R)-2,3-dihydroxy-3-methylpentanoate = (S)-3-methyl-2-oxopentanoate + H2O</text>
            <dbReference type="Rhea" id="RHEA:27694"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:35146"/>
            <dbReference type="ChEBI" id="CHEBI:49258"/>
            <dbReference type="EC" id="4.2.1.9"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:27695"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="13">Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 3/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 3/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IlvD/Edd family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.9" evidence="14"/>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SG91"/>
    <dbReference type="OrthoDB" id="3851628at2759"/>
    <dbReference type="UniPathway" id="UPA00047">
        <property type="reaction ID" value="UER00057"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00049">
        <property type="reaction ID" value="UER00061"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004160">
        <property type="term" value="F:dihydroxy-acid dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009097">
        <property type="term" value="P:isoleucine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009099">
        <property type="term" value="P:L-valine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.30.80:FF:000001">
        <property type="entry name" value="Dihydroxy-acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.80">
        <property type="entry name" value="IlvD/EDD C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00012">
        <property type="entry name" value="IlvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050165">
        <property type="entry name" value="DHAD_IlvD/Edd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042096">
        <property type="entry name" value="Dihydro-acid_dehy_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004404">
        <property type="entry name" value="DihydroxyA_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020558">
        <property type="entry name" value="DiOHA_6PGluconate_deHydtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056740">
        <property type="entry name" value="ILV_EDD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000581">
        <property type="entry name" value="ILV_EDD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037237">
        <property type="entry name" value="IlvD/EDD_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00110">
        <property type="entry name" value="ilvD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002068">
        <property type="entry name" value="PRK00911.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21000:SF5">
        <property type="entry name" value="DIHYDROXY-ACID DEHYDRATASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24877">
        <property type="entry name" value="ILV_EDD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00920">
        <property type="entry name" value="ILVD_EDD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143975">
        <property type="entry name" value="IlvD/EDD N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52016">
        <property type="entry name" value="LeuD/IlvD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00886">
        <property type="entry name" value="ILVD_EDD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00887">
        <property type="entry name" value="ILVD_EDD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="10" id="KW-0100">Branched-chain amino acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase N-terminal" evidence="17">
        <location>
            <begin position="72"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="domain" description="Dihydroxy-acid/6-phosphogluconate dehydratase C-terminal" evidence="18">
        <location>
            <begin position="403"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00052865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF24877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RDW85369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="599" mass="63804" checksum="EB29B8E961118E47" modified="2019-01-16" version="1">MPPILRTKASRALAFNGLLNRHVGVRQLSHTAARDADAKLNKVSSKITQPKSQGASQAMLYATGLTEADMAKPQVGISSVWFEGNPCNMHLMDLSSVVRDSVAKAGLVPMRFNSIGVSDGISMGTTGMRYSLQSREIIADGIETVMNGQWYDANISLPGCDKNMPGVLMAMGRVNRPSLMVYGGSIKPGCSSSGQQLDLVSAFQSYGQYLTGEINEQQRFDIIRNACPGSGACGGMYTANTMASAIETLGMTLPGSSSCPADDPSKMKECEGVGETIKNMLKEDIRPTDIMTRQAFENAMIVVNILGGSTNAVLHLIAIADSVGINLTIDDFQAVSDKTPFLADLKPSGKYVMHDMYKIGGTPALLKFLLKEGLIDGSGITVTGKTMKENVASWPEFAADQAIIRPRSNPIKPTGHLQILRGSLAPGGSVGKITGKEGLRFEGSAKCYDYEDAFVEALERGEIKKGEKTVVIIRYEGPKGGPGMPEMLKPSSAIIGAGLGNDVALLTDGRFSGGSHGFLIGHIVPEAMEGGPIALAKDGDRIVIDAEKRIVDLEISPEEMANRRKEWKAPESRAKKGTLRKYALLVSDASHGCVTDGPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SGW1</accession>
    <name>A0A3D8SGW1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_03871</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SGW1"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015233">
        <property type="term" value="F:pantothenate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098717">
        <property type="term" value="P:pantothenate import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000386">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF4">
        <property type="entry name" value="PANTOTHENATE TRANSPORTER FEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="32"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW85546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="475" mass="52818" checksum="6851642DDDB8F3CB" modified="2019-01-16" version="1">MGTAQRLREYLSPGSAHQPGEAKLVRKLDFFILTFCCLMYFTNYLDRSNLANAYVSGMKEELHFVGNQYNLINTVFTVGYIIGQVPSNLALYHITPRIYFPTMMVIWGALTMITAAAKRPGDIMAIRFFQGLAESSTFVGTHYILGSWYTSAELGKRSGIFTSSGLAGTMFGGFLQTAIHSSLNGAKGLSGWRWLFIIDGLITLPIALYGFILFPDTPSTTHAFYLSSEERALAISRVPEVPERRPWNFGFLKRILTSWYWYGFVILWIIAGETESFSSNSLLSLYLKSIGGYTVSQLNNYPTGVPAVGIVSTLFWATLTDFMGGKRYLVGYWIALTGIINSAMILAPGSSVAVHMAAYYWAGSVYACQATFFAWANDAMRYEEDSLRAVVIGSMNAGSNAVNAWWSLLFYSANFAPKFTKGMWAMIAMCILLAIWTTGLIWMVDRTEKKRLTEQEVVAAEKPEMVTTGVGEEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SH11</accession>
    <name>A0A3D8SH11_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_03962</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SH11"/>
    <dbReference type="OrthoDB" id="5431075at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW85637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="393" mass="41377" checksum="9E149A89B3397504" modified="2019-01-16" version="1">MASDCYYPNGNLSSDVSCGTASSGASVCCPSGSSCGDVTSGICTSTGNVALRGSCTDQTWKDSNCPSLCAGVDLAGNAIVTQCSNSGLWCCGTDCCDDASRLFTVVSRITAPSAASQSSGGSSVLSFPLQATGSSNTGGKKGTSQEPGTPFPPDNETHKPHHVAVALITMITAGCLAIAGSVFLFFVLYRRQGKEQRAEMDQQVAGDATGSERVRGISILNLTHLPTSHPPQYSESQENLVRKNNISPLHWPEGWTEQRQRDTSQPSSPLPLSPHSSWNTPSNLLYHSSIPVNNSPISELSSSPISYPSPVYQTPSQELAAARARSLASAPQSPVGPVSILEISTAEARTAEHSWGLSNAELRGSQSTTEEVRRRSVGNRLSEFPLDVKSELP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SH98</accession>
    <name>A0A3D8SH98_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_03876</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SH98"/>
    <dbReference type="OrthoDB" id="2898618at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009688">
        <property type="term" value="P:abscisic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF18">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G12480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW85551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="285" mass="29428" checksum="30E44EBCFBC7AFD5" modified="2019-01-16" version="1">MATSSIQAANLFAVNGLVAVITGGGSGIGLMMARALALNGAHKVYIIGRRKDVLEKAAASVTTSNIIPIVGDVTSKSDLESIAARITSEEGYINVLIANSGILGPQAKPSISPSMTLSEFQDAFTSTTFDDFVNTFAVNVGGVWLTIMSFLSLLDAGNKKGNVSQKSQIITTSSIASFNRAVPGGYSYGQSKAAVTHLTKQLSTGLVPYEIRVNSIAPGLFPSDMAAGLIGDGNLPKSKVPLERAGSEEDMAGAVLFLASKAGAYVSGNILLIDGGRLSIHPAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHU3</accession>
    <name>A0A3D8SHU3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxal phosphate homeostasis protein</fullName>
            <shortName evidence="2">PLP homeostasis protein</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_04215</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHU3"/>
    <dbReference type="OrthoDB" id="10264196at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06822">
        <property type="entry name" value="PLPDE_III_YBL036c_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000007">
        <property type="entry name" value="Pyridoxal phosphate homeostasis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00044">
        <property type="entry name" value="YggS family pyridoxal phosphate-dependent enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146:SF14">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE HOMEOSTASIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01211">
        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine racemase N-terminal" evidence="5">
        <location>
            <begin position="26"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2 3">
        <location>
            <position position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW85890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="266" mass="28862" checksum="7904676019115668" modified="2019-01-16" version="1">MSCDEMRVDPARAKTLVSQLQAVSERVTKAASGRSVRLVAVSKLKPAADILALHQEPTSWVHFGENYAQELTEKAELLPKSISWHFIGGLQSNKCKPLAASIPNLFCVSSVDSSKKATQLDKGRAELVQAHPEIQDKLNIHVQVNTSGEEAKSGVAPGAETLDLCKHIVKECPNLNLLGLMTIGAIARSKATTAENENEDFVTLREERDKVAQELGIELELSMGMSEDFEGAIALGSGEVRVGSTIFGERPNKADFKVKEAVEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SI29</accession>
    <name>A0A3D8SI29_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_03753</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SI29"/>
    <dbReference type="OrthoDB" id="4005299at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018825">
        <property type="entry name" value="DUF2427"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018827">
        <property type="entry name" value="YTP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685:SF3">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31685">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_6G12730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10348">
        <property type="entry name" value="DUF2427"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10355">
        <property type="entry name" value="Ytp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="428"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2427" evidence="3">
        <location>
            <begin position="12"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Protein YTP1-like C-terminal" evidence="4">
        <location>
            <begin position="200"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW85428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="500" mass="56135" checksum="356135DDBC01F231" modified="2019-01-16" version="1">MSNSLDEPHLPPKSYMRHPEHVTLILAHIVLMTVGWVFCLPVAVVFSVARSHLTVAAQLVFLSINALGVLIGIIYNRSTPNLYEHGKHGTVGYIITLLVFAWVFLGFVDTYSRRNLHKRHLTGSDFSLQDDESENSIVDTTPEYNDDYNEPDSGDDEKHGFLRGKIVNRFLKGNFARFRRTIRAIQLFHLVLERAALVLGFLGITTGAVIYTGIFHDHNIFNGLAHFIKGGIFFWYGLLTFARWMGCFADMGWAWNRKPSRTLVGKVASMPSAEFVESAVICFYGVSNVFLEHLANTDGKWAAIDLEHVSITLMFFSGGLLGMIIESTYIRDLLRSNITIIRADSALPGESASFSQPRQYAFSMNPMPALIIYLLGRMMSSHHQVSMVSSMIHTQWGNLFSDFALARLATYSLLYVQPPVGYLPQRPPTEVLSSFCLVGGGMLFMMSNRDTVIGLEWNELDAMFTFNVAMGLTAFLMAWSTVVMALKGWAQLRVAKEREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SI67</accession>
    <name>A0A3D8SI67_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_04308</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SI67"/>
    <dbReference type="OrthoDB" id="2151789at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF53">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017764912" description="FAD-binding PCMH-type domain-containing protein" evidence="5">
        <location>
            <begin position="21"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="76"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW85983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="509" mass="54511" checksum="3BF452F1BA27DA97" modified="2019-01-16" version="1">MLFSKSSLSGSLLAAAVANAQNVTSSNTTSTIPSVDLLTGANCACTQLAAQYGSLVLTSNSTNYTAETINYWDTRADLLPSCIFMPTDADQISTAVNTFTSCGTQFAIRGGGHMSFPGSNNINGGVLLALNDMTLLRVAADNSSIEVGPGNRWGDVYNALAPYSLYCIGGRLKAIGVSGLALIGGFHYLANTYGLAMDNVLSYDVVLGNGTQVVANKTSNPDLFWALKGGAGNFGIVTKYTIKALPIPLVSTTIQSFDEAAIPDFIAATVDMAQNNGPDIAAGSVISLSYNITTKKASASLLGVQAGDVSPPSRFANFSAIPSVVAINNVSTPAVWQSQLDSPNQMSRIQFAHKTIKPDYDHLYNIYEAWKVASDDVQDVEGLYLTFVMNILPASALSVAKNNGVGNTWGLDDNQSYILWQLSTGWTNAYDDLRMTNWARSFVDYWHLEGQTLGLASEFLYMGDSGEFQDPFAGFPIANVQRMRSTRDLYDPLKVFSRLNWGGFKLGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SLV8</accession>
    <name>A0A3D8SLV8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_03023</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SLV8"/>
    <dbReference type="OrthoDB" id="2980193at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW87329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="320" mass="35616" checksum="CE73EFA49B213131" modified="2019-01-16" version="1">MASPSASSATISIHSNGSEEDFFTLPLEYMNPTSESEPSPSMLASTHPDPLFLQAVLYNCSRLHPQRLLGRFLFGTAPNTDYKVILTPGHEYDRRDTWIHSWPPTSMADFGPDSTRSSKSPVGISSSLMEAIRARLPQNLNILHAAHANPDGLPLDILEQHAAHYLRFRPRLLSLSGLQDVATRTTLLNCMSLPQVSNLTFEEVGDRFWDGMAPFWCEEDFTPMNYFPYGDEIPSMLCAVKTGSIDILRQLMEFGADITFWTSPQFYVPDPPTPSSLAITTPLHVAIQAGDLTMLSYLLNVHHFDPNAMALVAPTRCHTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SLY0</accession>
    <name>A0A3D8SLY0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03017</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SLY0"/>
    <dbReference type="OrthoDB" id="3836772at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39602">
        <property type="entry name" value="ACW-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39602:SF2">
        <property type="entry name" value="ACW-9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017814590" evidence="1">
        <location>
            <begin position="18"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW87323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="138" mass="15190" checksum="4670514620794BBA" modified="2019-01-16" version="1">MQFPILVLSTLLTTALAALPPYPRQSSGWTIRKFTRDCTNPNTCIYNFNIDTNDGSTPAPCTIVNTGNPATTQAWYGVACQQPNDWQISWGWDHQGDFTVMTTMNIASKLEAFFGYKSPNANSNATYSDNGPQTPQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMC7</accession>
    <name>A0A3D8SMC7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carboxypeptidase</fullName>
            <ecNumber evidence="7">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_03169</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="7"/>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SMC7"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000118">
        <property type="entry name" value="Carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033124">
        <property type="entry name" value="Ser_caboxypep_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF116">
        <property type="entry name" value="CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00560">
        <property type="entry name" value="CARBOXYPEPT_SER_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 8" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017496931" description="Carboxypeptidase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW87475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="545" mass="59565" checksum="E864F81860254F98" modified="2019-01-16" version="1">MHTFNCTSLLLAASAATALQSPHDRVRHVTRSESVSAPRNPTIKPRSTSKYLTNVTTPFAVNGSALPEFDFDIGESYAGSLSISSNATDENKLWFWFFPSSNPLASKEITIWLNGGPGCSSLDGLFQENGPFLWQSGTFAPVPNPYSWVNLTNMVYIDQPVTTGFSKGTINVTDEVDVASQFKGFWKNFIDTFEMEGYSVYLTGESYAGQYIPYIASGMLDENNTEYFNVKGVQINDPSINYDDTLIYTPSVPALLKYQNVMNLNKTFLDNITARADACGFTAFHDLYTSTFPPPGPIPTAPDSTLPGCGVWDDIYNAAYYVNPCFNIYHLTDYCPFLWDELGFPSLGTGPNNYFNQSDVQKVIHAPPTDYAVCAGGSNLFPEGDLSVPSGLGPLPSVIERTNNTIIGHGDLDFLLFTNGTLITIQNMTWNGLQGFQTAPSAEQNLFVPYHETIGEILDLINGAIAYTPGFTDTAGGGYQGTYHTERGLTFVTVALAGHEIPQYVPGAAYRQLEFLLGRIDNLGQRGDYTTGPQGNYTGVSAPLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMR8</accession>
    <name>A0A3D8SMR8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peroxisomal ABC transporter-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_03333</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SMR8"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005324">
        <property type="term" value="F:long-chain fatty acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015910">
        <property type="term" value="P:long-chain fatty acid import into peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042760">
        <property type="term" value="P:very long-chain fatty acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF67">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY D MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="174"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="529"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="749"/>
            <end position="786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW87639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="811" mass="91270" checksum="9D122157DE815D64" modified="2019-01-16" version="1">MAVQSTLQHQDPVAALYHRYIDLMRSRFKGTTRATRLVGTILLAITIIVTGTGSRRWWLKKKAEKEQGRRLLRRNSGLRLKDGSRVIFVPYGDSTSKVTIHPTKPTTFDAHRRLFLNPPRASGLTNGQTTPQIPPPQTKPGLNLAFLHQFLSLLSIMIPRWRSKETGLLLSHGVFLMLRTYLSLVVARLDGEIVRDLVAGNGRSFMWGIVKWCGIGGFASYTNAMIKFLQSKVSIAFRTRLTRYIHDLYLNDNLNYYKLSNLDGGIGQGADQFITQDLTLFCASAASLYSSLGKPFVDLCVFNYQLYRSLGPLALTGLLSNYFLTATILRRLSPPFGKLKAVEGRKEGDFRGLHARLIANAEEVAFYGGSNMEKIFLDKEFRSLKKWMEGIYTLKIRYNILEDFVLKYSWSAYGYLLSSLPVFLPAWGGLGGRQEMIETSTSGGKERGRMKEFITNKRLMLSLADAGGRMMYSIKDLSELAGYTSRVYTLISTLHRVHANAYFPPRGTHAELFSLSDVQGTIQKGFDGVRLENVPVVAPSVFPHGGEDLIDSLSVIVHSGEHLLISGANGVGKSAVARIVAGLWPVYRGLVSRPRSIGTDGIMFLPQRPYLSVGTLRDQVIYPDGEMEMRDQGRRDIELKRILEEARLGYLPDREGGWDTRKEWKDVLSGGEKQRMAIARLLYHEPRYAFIDEGTSAVSSDVEGLLYERAKEKGITLITISTRASLKRYHTFNLTLGLGDDGNGWEYERIGTEKEKMGVERELTELRERLSKVEQWKARTEEIERELAPVWTEQGVLSPPPYSAELEHAGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SN70</accession>
    <name>A0A3D8SN70_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03459</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SN70"/>
    <dbReference type="OrthoDB" id="5324692at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW87765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="825" mass="91377" checksum="C857262F640AB587" modified="2019-01-16" version="1">MQVFKKAQIKVKAAVKEIQSATEKAGDSTRERQYLVTRKFSNQDHEQNPPNFGPFSKHRKSSSLQKSPYTIPSEPCTPCKDPIDKENILPFQQPQLPDFKFSQISLCEPPKAQVQATPQSPTVQVIASTCTGTEAVPTDFAQFYVLKPGVLPTGSSDRTVQDFAICHHCFSSNVAQVPSLASKFVRVARTDASRKESLSLLSYDTLLCNFSWPRVRQTFLTRCVPTNSIRALVEFATLLPVLTTCEGTWQPSGQEFYSSTSWPDSGLCVTCFETYIRHSAFEPHFNLQRDDADPNRLWVCDLGLYPYLQRVLRAELESSSPSFQGFLAAAKERQLIPDCPGEGNPIVAVGEEKAFAFRAPGEKAGVFCSACYYDRVHGTSLDGFFEKKFELQGDQEGILICDLASEYSQTAIVAAIHEKDADLWGRLVAKRGTVPNCVGVIGMDEEEIEAQKASFGDLANWYYLRGFPNIEICPQCYWTTTALVGAENFFTPLSRPLKNGIIRQCFLTAPADPSADVNDPTGFENTLAWRGQMLRSMLQYASSTDGDFSRFLSLAKVISKFPTPCGGQFRRYKEGSGRRWLGKTAKNKKDLNDCTLMICEECHLSIVKGTALEGQLSDDVTSSTFDYDNGYSCPVYTKLIRKRLGEACRSGNLDVFAAYWNKRAEVWKRYEPWPAAMAAQRKALGQETANTIAHTSIQTQQGAIQLTNQMNAQTNAFMMGVGLLVTEASTFGTSSPFGNSVVSNTIISRSVGSYSSNKLPNFMQQLFPEYQTSVGAQPAQAHHDAASLPGSDVITPEFAGLNDVEKTEAMLARFMELHAEWAALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SN84</accession>
    <name>A0A3D8SN84_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Antigenic cell wall galactomannoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03446</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SN84"/>
    <dbReference type="OrthoDB" id="2422134at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021054">
        <property type="entry name" value="Cell_wall_mannoprotein_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123">
        <property type="entry name" value="CELL WALL SERINE-THREONINE-RICH GALACTOMANNOPROTEIN MP1 (AFU_ORTHOLOGUE AFUA_4G03240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123:SF1">
        <property type="entry name" value="HYDROPHOBIC SURFACE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12296">
        <property type="entry name" value="HsbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017661545" description="Antigenic cell wall galactomannoprotein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW87752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="173" mass="17715" checksum="679E5EE83648050E" modified="2019-01-16" version="1">MLINLVPLTLLITAVLASGDAIAAAMGKIANSTMALNKTVGTFPSGVLAAVSDALPLLSDSATLLADINSGTQIAKASANLTIPEAFQIASATSSLATTVQQTLATVENAKKKFDSLVFISPVILLNLKMEKDATDKFSAAVVSKVPDALQGTAKSLIAPIDTAFDSAISFYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SNE3</accession>
    <name>A0A3D8SNE3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_03395</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SNE3"/>
    <dbReference type="OrthoDB" id="5977743at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF4">
        <property type="entry name" value="METALLOPHOSPHOESTERASE, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="682"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="566"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="570"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="583"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW87701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="701" mass="78838" checksum="28D9EDB1CF925197" modified="2019-01-16" version="1">MAPSYHSSSYPTARDESPTLLNRIIAALPRNLATQAQELLDKYSYSPVSTSSSRSPKTLRQARAGFSFSFRKLLSVPYLLVAIWIVVLLWGERWVFESSIAACQWGSWERWPRGATPHHLVLLADPQLTDPHSYPDRPWPLSTFTIWHTDNYLKRGYIQLQKQLFPDTLFFLGDLFDGGREWKTTHGNTDDPAWTKGMRPQVEEKWLKTWNRKYGEKFWLKEYDRFGRIFFNFWNLGTTEAGVGQRGRRIIASLPGNHDLGFGAMIKIPVRNRFETYFGEGNRVDVIANHTFVSIDGVSLSAGSSGRPLQETINITAPVEEFLDGVQAAKRKAVARELRFLAGEKNELHLPHTVEEAEDIDVSKMPTSDPGEGAPELPTILLTHVPLYRNPDTDCGPMREHGKAISISRGYQYQNVLSEEDSVKVVSKVGNVVSVFSGDDHDYCELVHPENKNHAREITVKSMSWTMGVRRPGFLMLSMWNPITPEGKPSHSMHTGHGAASAQTSPTFESHLCLLPDQLGIFMRYGVLLAITFIALIMRAVLTPFLGLDPFAAPLSDFEQELSILPTSTRDTDREDKSPHRFSNSSTSSTSSNSAGLASRSAAARTRSVSPANGYGFPQAQSLVRNAVPPFIDSAGYYVNPYGGVKYPEREEPIKVKAPVYDKVPRRNLTKLEIIGRELYHSIYRVAWLVGGWYLWLAWFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SNG0</accession>
    <name>A0A3D8SNG0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_03415</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SNG0"/>
    <dbReference type="OrthoDB" id="25131at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039328">
        <property type="entry name" value="WDR89"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22889:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 89"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="147"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW87721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="315" mass="34372" checksum="7E40C6BA1EA75B16" modified="2019-01-16" version="1">MYLLNNTSTFHVKSPADTYIYEIVADSKLGDILVSISSDNCLRVLNPLDLNGPPIREIKKVIEEVTCLKFLGESVVATAGRDGLVGLWDLRNGEKVGSVRSEQNAPILSLACLSPNGLAAGTELTNHQATVSIWDSRNLGQTMRQYIESHSDDVTELQFHPSHPSILLSGSTDGLVNIYNTTIEDEEEALHQTINHGSSIHHAGFLSDVDIFALSHDEKLATHKLVTNTEETVEEPLPVQYGDLRELLGGEYVANVVSRPDGAAVVGIGTHSRESFDLIHFNNSPPWTFAPESKVTLVGAHGSEIVRSFCFLDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SNL0</accession>
    <name>A0A3D8SNL0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 25">tRNA-dihydrouridine(47) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="4 25">1.3.1.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="25">tRNA-dihydrouridine synthase 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">BP5796_03478</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28 29">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>5,6-dihydrouridine(47) in tRNA + NAD(+) = uridine(47) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53364"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="20">
            <dbReference type="Rhea" id="RHEA:53366"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>5,6-dihydrouridine(47) in tRNA + NADP(+) = uridine(47) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53360"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="23">
            <dbReference type="Rhea" id="RHEA:53362"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="21">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="22">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 25">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="25">Belongs to the dus family. Dus3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.89" evidence="4 25"/>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SNL0"/>
    <dbReference type="OrthoDB" id="259935at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106414">
        <property type="term" value="F:mRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102265">
        <property type="term" value="F:tRNA-dihydrouridine47 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000145">
        <property type="entry name" value="tRNA-dihydrouridine(47) synthase [NAD(P)(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25585">
        <property type="entry name" value="zf-CCCH_DUS3L"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 25" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 25" id="KW-0288">FMN</keyword>
    <keyword evidence="11 24 25" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="17 25" id="KW-0520">NAD</keyword>
    <keyword evidence="15 25" id="KW-0521">NADP</keyword>
    <keyword evidence="18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16 25" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 25" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="14 24 25" id="KW-0862">Zinc</keyword>
    <keyword evidence="13 24 25" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="27">
        <location>
            <begin position="180"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="24">
        <location>
            <begin position="180"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="26">
        <location>
            <begin position="56"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="26">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="26">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="26">
        <location>
            <begin position="170"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00045934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00048266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="RuleBase" id="RU291113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="RDW87784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="775" mass="86407" checksum="58C485A14BEE5C35" modified="2019-01-16" version="1">MTENSPADASNPLKRSLEQDHAVATQPILPEDSVVTKAEKVESNGLVGEAVLTEPATKRVRLEGETANSVQESNGKTTASNGSKQDAEGVARELPGSGPPESTNGNSRQKVKGVALVKEEYLITPTGTRSPQIDDDAAEGRDSRDSRDSRDTRDSRDKRDGGKKKKQKGQNTARQFGSSQDTIKLCVSRANSSEFSPKQCKFGDKCTFTHDLRKYLAEGKRGDLETFEGKCPVWEVNGKCHAGWKCRFAKSHSKEIEHEDGRKELVLIEDPTRVTSEGFEDDENRAGVFNVVKTAEKLCLAKRQMKLEKSEVYSVWLDKEARELEKIYQRKKDDANADREENRANFVDPPLLPSEKRRIYFGPETPVLAPLTTQGNLPFRRMCVEFGAQITYSEMAMTLPLLQGQKGEWALLKAHESEISPPRYTPTSIVQTYDNSKDLKFGAQVSANRVPEAIRAAEAISLLVPHLRVIDLNCGCPIDLVYKQGAGSALLDAPSKLEKMIRGMNTVSGEIPVTAKIRMGTKDGKPNADKIIERMAFGSSSREDRLGAPGCAAITLHGRSRQQRYTRNADWSYIADCSALIKSYNQKKADKTDTIREPDARTLPNSPDGKMYFIGNGDCYSHVDYLSNIQNSGVDSIMVARGALIKPWLFEEIEKGQYLDKSSSQRLGYIEKFARFGLEAWGSDEQGVGLTRRFLLEWLSFAHRYVPVGILDHLPPSLQDRPPAFRGRDDLETLLASDNYLDWIKISEMFLGPAHKDFKFQPKHKSNSYEIQAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXM1</accession>
    <name>A0A3D8SXM1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02221</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SXM1"/>
    <dbReference type="OrthoDB" id="3565233at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF12">
        <property type="entry name" value="AT HOOK TRANSCRIPTION FACTOR FAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="861"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="274"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="865"/>
            <end position="884"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="925" mass="103136" checksum="A6F25347038F1C6B" modified="2019-01-16" version="1">MEQTATLSSIETLLKHTITYCNQLSQVLHTWTVLQDCPRPGYFDECLQSIDDTTQTLAQLSAIIEIQRNPASKPLFNKEGLARASLLTKECFTEVSRIELAIRKCASRGVHVEVSDQAHASRGTLTASEFLETKNADPLLKSFDAKEFLELVERMRCVLIETDIERCVTRLRDLTQNIILLSQIAELQRRCVFPAFSQITLFNVFDAKNACSYDGEKPSVEDTVILYARISRAADLVDLAPDEEDESDSSSTYYDTESNSDSDSDSDSERSARSRSTCGSRSRSRSGSSRGTSYPMRPRGRRVSFSLRRGGSVGSDRSFSPRPRSPPRWPTPIQRWSDRSLTPPPRQVPPFTNARTSVAFASPGNENGSPPSYIESRRPFSSGPCTVISMAAPIPPVSPFKPGKSTVSVEVSEQAEQAETVEIVPNVTPKEGQLFKSEPHGMFYKLQFYLRPSSLAAEITSVLAATDSKLSAYLIQTNMLREIPHSAFHTLESTHLRALLFHGSNTSNGWYKTFCKLTNDEHRQLDGVLHQRDANGVLRHREIVVLQVAKQNKANMWLRMLVRRLGNGTRVELPVEVRNNRVILAIMREKISENIPPLPAGTYAYLGAHPPPPPVVPVSQVRVPPLPIIKRPDGPSDLRILPPPPLVPSYPLPPPAGRSVGALQGVLTPEKAREALTTFNEYHLDVLPASQAPGAPQQPPNWQRINITQSTTAGPTDLLKHLNAELINNCTLNPTPPPTPTHTTRTEVFNSHPPITPAQDLHLSRLLAQLQASDRDSNFEWKWVWLGLRFGTGSAQELQEFTGVQNATSIHVIAARTPVAGIDCIALYGEMCKNPFSPRLTHHPPPLRRAPSPVVVVRTPVSPRARPRPRSRTPLREVARRRRRERQEKEWIQSRAEEDLQIRFGDLAPSRKGIADALLKLWCRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXX8</accession>
    <name>A0A3D8SXX8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein-18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_02352</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SXX8"/>
    <dbReference type="OrthoDB" id="2962696at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF1">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="225"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW91187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="273" mass="29266" checksum="4C4E1E38F93F13C4" modified="2019-01-16" version="1">MSSTESLRADKLFSVKDYICVVTGGGTGIGLMAAQALAANGAHVYITGRRMEALDQAAKNHSPANGGKITPIGPCDVTKKGDLERIVAEISSKEKYINLLVAAAGISGPKAEPDEEDASKLKEKLMSNESFAQWSDTFNTNVTSVYFSTVAFLPLLQAGRESHGHLSASVIVISSMSGIMSHAQGHFSYNAAKGATVHLSKLMAYEFKKAGIRVNSIAPGYFPSEMTTKESDEHQKSELPDHKIREKGHVPLGRAGSDEEMAQGIIFLTKNNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SY07</accession>
    <name>A0A3D8SY07_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-mRNA splicing factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02305</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SY07"/>
    <dbReference type="OrthoDB" id="61370at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.150">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="200" mass="22102" checksum="9E01DEDD06B6DC5A" modified="2019-01-16" version="1">MTRVIVYTAALAAFIAATAMTFAAIFIPDWITWESTSPSGGHFTKTVGLHRSCSSIDSQKPTCAHFPQYEDCHGTDRYFCSMWRSVGFLMSFAAVFELATMVAYVVVILGGKQKRETGWKILGFLLVLVAVVQCAAMALVAYLFDNDDRFFVGWKLDKSWILCTISWSIAIISAALISLSAFVFPPEDGYELIPSERHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYJ5</accession>
    <name>A0A3D8SYJ5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Mitochondrial protein-like protein import receptor tom70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_02406</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Tom70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYJ5"/>
    <dbReference type="OrthoDB" id="2942533at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015450">
        <property type="term" value="F:protein-transporting ATPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005687">
        <property type="entry name" value="Tom70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00990">
        <property type="entry name" value="3a0801s09"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46208:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="13" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="2 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="372"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="406"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="474"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="10">
        <location>
            <begin position="549"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="63"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW91241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="623" mass="69069" checksum="3D58506E86D0BD08" modified="2019-01-16" version="1">MSAPATMPPQRSVPDFALPTSQSSVWDRITTWASENKAVVYTIAGVAVVVTGAGVAYYLTDSKSSSADSKDTPKKASKSKRKKKDEKKGADLEKGTAPQDTKPKAPAAETTEELPEVDESTVGNLSEQERKDYAAKLKAAGNTAYGSKDYNKAIELYGKAILCKPDPIFYSNRAACYNALGEWEKVIDDTTAAIALDSEYVKALNRRANAYEHLEKNSEALLDFTASCIIDGFRNESSAQSVERLLKKVAESKGKAILASKDKRLPSPTFVTNYLQSFRVRPRPEGLDSKAELAEDTGKGQLQLGLDAMDKKTGDGYEEASAAFDKALELNELGEYEAFAYNMRGTFKYLRGNNVEALSDLTKSIDLQPALTQSFIKRASMHLELGDREAAAVDFEKAMEQNSEDPDIYYHRAQLHFILGEFADAAKDYQKSIDLDTSFIFSHIQLGVTQYKMGSIASSMATFRRCIKNFDKVPDVYNYYGELLLDQQKYQEAIEKFETAIEMEKQTKPLGMNVLPLINKALALFQWKQDFAEAEKLCQKALIIDPECDIAVATMAQLLLQQGKVTEALKYFERAAELSRTEGEIVNALSYAEATRTQLEVQEKYPQLANRLQGMGGGFGSMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYL7</accession>
    <name>A0A3D8SYL7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Acetyl-CoA synthetase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_02567</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYL7"/>
    <dbReference type="OrthoDB" id="3633556at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05926">
        <property type="entry name" value="FACL_fum10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045310">
        <property type="entry name" value="Pcs60-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="28"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="6">
        <location>
            <begin position="421"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW91402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="516" mass="56256" checksum="99AABD9A44ADF215" modified="2019-01-16" version="1">MATTLSDSFPSGGDATAIIIPSKPNPLIVSYSQLAAEVASFQKKLARLGVTPQAAVSIALPNTYEFIIAFLAASWQRGIAAPLNAAYKQEEFEFYIDDLKSAVALVPKGSFQQDGAAVRAARKYNAAIAECYFDGREVVLDVKDEGKLKGKGNQKVEKAQPDDIALVLHTSGTTGRPKAVPLTHKNLTRTMKNIKATYELTPADRTMLVMPLFHVHGLLAGFLAPLHSGGSVIVPPKFSASEFWDDFITHKANWYTAVPTIHQILLKNPPPQTKPNIRFIRSCSSPLSPTTLHLLEETYNAPVLEAYAMTEASHQMTSNPLPKNGKHQPGSVGIGQGVEVKILDQDGKEVEQGKEAEICIKGENVTNGYLNNPKANKESFTANGFFRTGDQGKKDKDGYVIITGRIKELINKGGEKISPIELDNVLARHPAISEAVSFAVPDEMYGQEVGVAVVLKSGQKLSESELRTWVAEKVAKFKVPKKIYFTDSMPKTATGKIQRRIVADTMMKQDTPKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZ29</accession>
    <name>A0A3D8SZ29_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_02705</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZ29"/>
    <dbReference type="OrthoDB" id="1747771at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374:SF1">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE PAD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="2">
        <location>
            <begin position="121"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW91540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="394" mass="43921" checksum="3B6A7555BE82B0AA" modified="2019-01-16" version="1">MYADIVLPIYPGLVDPELFDAQLKLLLDNRDEVIADADNISSTSNPQGASWFALLFAVLACGAQCISTIEREAELNSKVFGSVSFCFLRKANYLVSPCLNTTQALLNIGISLRNDMHSSVAWSILGITIRHAQLIGCCDKPTALSNDNISNDLYNGKLRLWWAIVWQDISLSFCYGRPCGSLSVKARFPPTLDPNGRYGFIDVINRICGTCHDFYRQTLLAEEDVPLSQDIVENFVEKFEKIHQKAQPHLLDVVNCLSPRHHVEFFVVTVYKTHAACRLLKTLIQAPEAENRNGYDRIMDKITVLSVETVEAFMLLRQFSILTSLYWSLVQATITAAKFLLTRSRGADKPAWDSLVGSLMVSLRSSCDETTSIRNGFTANLSKLVAELSILVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZ95</accession>
    <name>A0A3D8SZ95_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Complex I intermediate-associated protein 84</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02253</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZ95"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051240">
        <property type="entry name" value="Mito_RNA-Proc/Resp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47933">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47933:SF40">
        <property type="entry name" value="PENTATRICOPEPTIDE REPEAT-CONTAINING PROTEIN 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="792" mass="91032" checksum="C90FA9ABCC92CD2D" modified="2019-01-16" version="1">MASHLTRQVFRALLSNEGLVLRCPNRTGALCRRQHALSLRSRLPSRRTLFGFSEKAAKLPKEPSLVPGYRQMLELNSREKLQARPPPHDELVKAFAAFFNHKRISEESINNLQAQHALRTFRYIQKNAASDGGDGLTNESLRNAMLCLARKPNDQTDWHCIFAKELYAELARRNNPDPNFITSIRYIKVLTFSGNSLAARDQILALSKTNSNNIEPRKGTKAHWWPLVLEGFAAENNESELVKSLELAKEDGIDYTPRFQYVVTKFYFSKNDTAKARFWFDKALAERKEGEVPHQPLPETLVEMLRFSIRNNELDWCNTKFRQLLDSEPTKPLWDVIFQWAAGALGKGVEDVERMMDVMIRRYPEEDGMRPDADTINGLVQLAVHLEDPYLAERYLSMGQKRGIRPNSETFMLQLDYRIEAGDLTGAQAAYEALQIEVITNDEDLPIINKYIRALCTSKSANSDAIQMITSDLEQRHARLEADTVAALSTLYLNNREFQEVVDLLQTNAFHQNLEERALVRKAFVDFCFDRNTSTALAWETYTIILNLFKEADIKQRTGLMNEFFDRGRSDMACHVFGHMRAHIRKEIRPVAETYIQCFEGIAKHSDRESLDMVHNMLKLDVSIEPSTRLYNSLMLAYTACDDGYRALDYWSDITNSREGPNYKSLEIVFRACSRRPFGDQPAREIWTKMRRMEIEITPKVFAAYCGALAGQGKVDEVKSLIEDMEKDVGFGPDFMTLGIFYNSTKGQNRKDIIENWAKELYPKAWAELAVFEQIEEEEGWMTFKIVLDMTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZK2</accession>
    <name>A0A3D8SZK2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02889</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZK2"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF102">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="337" mass="37509" checksum="1755701D7B9AAF0F" modified="2019-01-16" version="1">MAAQNLTQSPQATTTDEQISTPIDTSSTSIANLEADSDDSNDDADSAIGRSLLSPTASVQESIYNFPEENGRSYHRYKEGRQIEKDRLDLQHHLCSLTFEGLHMAPLKTVDGGLHNVLDIGTGTGIWAIDFATQYPSAIVLGTDLSPIQPTYVPPNCYFEVDDVEDPWVYTRKFEYIHGRLLASCFESHLNVFKSAFSFLTPGGFIELQDAAFPNRCDDGSWNGSSFEKWMGLVMKGAKIFGKDWSSVSKYTQYLEEAGFVDIVEHKFYWPIGTWAKGARNKKLGLWCKENFFSGLQGFSMAVMTKALGMSAADVDMLLAEVRAEVESKKVHVYVPM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZM4</accession>
    <name>A0A3D8SZM4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Salicylate hydroxylase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_01159</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZM4"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000153">
        <property type="entry name" value="Salicylate hydroxylase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="14"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW91765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="440" mass="47703" checksum="9C9B65F5A091FF0E" modified="2019-01-16" version="1">MPETSAEYPNGGIAIVGGGIAGVTLALGLVNRGIPCQIYEQGHGFAEIGAGVAFAPNSIRAMRACDPSVYTAFKAVATHNLWESKCADITQGRKGLYFDFLDGYHDTDPSKPLFSLWNDEGANSVHRAHFLDEMVKFLPKDIAAFRKRVEGVEEVNNHVVLHFADGTTATADAVVGADGVKSHVRQSILGATNPESHAGYTYKYAYRGLIPMDKAIAELGEDMAANSKMHLGPDGHILTFPIDKGETLNVVAFTTTREGWPDLHKSTRPATKQNALDDFAGWGKNVTHILSLLNEDVDIWAIFDMLDHPASTYAKGKICLIGDAAHATSPHHGSGAGFAIEDSAVLAELLASPDAKSPAGIHAAFQAFDHCRRPRTQWLVASSRRTGELYEWQAKGVGADVEKIAAEAHDRFEKIWKGDITQMIAEAQTSFQKILEYTEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZR1</accession>
    <name>A0A3D8SZR1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication factor Cdt1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_02413</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Cdt1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZR1"/>
    <dbReference type="OrthoDB" id="341730at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1420">
        <property type="entry name" value="DNA replication factor Cdt1, C-terminal WH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032054">
        <property type="entry name" value="Cdt1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038090">
        <property type="entry name" value="Cdt1_C_WH_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16679">
        <property type="entry name" value="CDT1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26121">
        <property type="entry name" value="HTH_CDT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication factor Cdt1 C-terminal" evidence="4">
        <location>
            <begin position="358"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW91248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="487" mass="53335" checksum="079B2B30614ECFE3" modified="2019-01-16" version="1">MSAAIKRRKVSASSSASALARPRGLDAFTRISKATTPSKSVLDKNNYVDSSIVTRVEEAASPGRKRKLVTLEEENLDEEISMKVDPSRDVKPLPRKRTTTAATTRTPQTPQKPIVEDVSTTETPTKGARGLLDRLVLANTTPTRSPLRADAGSTAILDNSTTAHDLPHELLDLINLHAAFLTALTLHYAHNGTNSPADLRLLCPDVARAWGKRRVTVDDIRKSLGVMNSNYHTAGKGLSRLALSDYGHGKICIEINTTGPSRLARPLNENVMNHIFIQGLRDLWESQDSGDVQVTEFIQNLPAEAITTCSSVSKISPLLAKGQRRLEDMKAGIIFKKEAVKEKVSDEATVVTGKRPTLLERLRAKQLERSNMPPSATKEELQRKAALQRLEEVVAILTILSTSSSVGQQRVSFTLPTVMSKLRDSFKTPMSKDEADVALRLLASEIAPKWVKVVKMGKMEAMVVDREEKPDELALKESIVRASSCGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZV7</accession>
    <name>A0A3D8SZV7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_01230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZV7"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="211" mass="22638" checksum="75A01E7D993F0CCB" modified="2019-01-16" version="1">MDVRAPNPKNTASDPVSDAQHRLQPLQQGPPGDKSEQGSVSATEPFTTRRIGWLLSNVGSCCSARHSSSTSNASTLKDGKARRDGAKQHTDPRRYRPDGSFYQGLLSADISPLVGAHHAETDEGTTHRSATSGRGTVCTGRSVTRGHGRDTNFVQSADTREAEAKMIWGHLGAQLARLDGQARQGGEGSQHPVFFFAPLGHIRSYCDPIPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T020</accession>
    <name>A0A3D8T020_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_01306</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T020"/>
    <dbReference type="OrthoDB" id="447251at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429:SF2">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0157">Chromophore</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="6">
        <location>
            <begin position="127"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="PAC" evidence="5">
        <location>
            <begin position="348"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW91912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="623" mass="69531" checksum="5B9AA4D17C84B433" modified="2019-01-16" version="1">MAESMDQVLQNGQSYQETINGTLNQYEPVSPRRFRSMSFHKNGQHDTGLQRSKSKSGPRERYGSPPLSLDREGGADGRTATMRSRETSRSGSSGGYGTATPAGARNTSAGTSIGSEVHITDFFSPDVFQIVLRNPTTSHQFLKFCQSRSCGENMEFLEKACGFNFVCTEFLLGEVACQIWISHERKANWSDQAAQLLSSIHSTYATVNAPRQINIPSHISRQLSHDIKTSSNRTFPALESIFEGAQDHIEKLIASDIYPRFVKHQITTSAALALAKDRERFHGLGDCFCLTDPAIADNPILYASNGFVAVTGYSRKDIIPRNCRFLQGSMTDPRSPKRLTQAIKNGDEIVELILNYRKNGDPFWNLLYVAPLYDEHGTIKFFLGGQINVSTTVHSCTDVLRVLGQNIEEDDDRELVRSAHGRPRKSSLIEKPKSKNSFFKSWRTHRAPALSSREDLGVRDEVGIGGALLNRVGKMDIQTQLEAFYTTYSKYLILKYNTAPNMTSCTLKVSHYSPGVVDMLCLNLPNGSIAPIFHQDIFGVLASHGTISKAFKPTVLDNLRARRAISLDIGLMTGYEEKKGRFFGSSGAERSYRRVEEPYIAHWTPLMNDEEKVGWVVLMISPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0Y0</accession>
    <name>A0A3D8T0Y0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_01617</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0Y0"/>
    <dbReference type="OrthoDB" id="3358371at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF26">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="2"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW92223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="333" mass="36416" checksum="50C24B47A5A83F42" modified="2019-01-16" version="1">MAKTIVVLGVTGTQGGSVATEFLSQGWNVKGITRNTTSATATALASQGIELISADVDKPSSFTTVFRGAHVIFAMTDFWQPFFASFAELSQKSDRATGEHAYGVEVTRGKTIVDAAAKVLEEDGTLERFIWSSLPPMKKLSGGKYTYIYHFDAKAEVADYIRDKQPKLWERTSLLNMGFYTSNMIKYGGLMGVAKDKETGGYMMKKPGKNTAFHPLVVTSDTGKFTDLLVRTAPGKNLLACNGMTDYASFIKLWSEVTGVPCEVIEVSVEDCDKAAPGGIGREAGESTACSSEFGWGQREGTLVLPWEIDPNLKLTSLREYFESEDWEAFFAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T121</accession>
    <name>A0A3D8T121_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1996 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_01593</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T121"/>
    <dbReference type="OrthoDB" id="74764at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018535">
        <property type="entry name" value="DUF1996"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43662:SF12">
        <property type="entry name" value="DUF1996 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09362">
        <property type="entry name" value="DUF1996"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017575407" description="DUF1996 domain-containing protein" evidence="1">
        <location>
            <begin position="18"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1996" evidence="2">
        <location>
            <begin position="32"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW92199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="319" mass="34247" checksum="F2867008D6FB20C0" modified="2019-01-16" version="1">MLPAILLLTGAAGVANAYTIVAGDTFMFKNIDPIVMPGEYKSHMHTFMGSDAVTINTTTSAELRKGCTSAQSLNDQSVYWTPTLYYTGAGSDYTPLAPYRFSAYYENIAEAEIAIPEDYKVVVGNAAGTTQADVDAAGTTASWFCEGDSAPASKEAAAFPTTTCSTHLQHIVRFHDCVNPTNISEHSYSGRQNLPNTNRCPTGQSRIPQLRFSIRYDLRKTISSGWSGAPPLTLACGSSFCAHGDFINGWDKTALTNMLNATSKTEYMYINGSLQTGSGGDPTCGPTDADPNNGTNDYLKSVAMMAAKKMVKRAMSFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1H9</accession>
    <name>A0A3D8T1H9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_01831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1H9"/>
    <dbReference type="OrthoDB" id="5238363at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW92437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="114" mass="13104" checksum="2A3B57D5475070C6" modified="2019-01-16" version="1">MVPSEDAKKRVIRSHLTRKLRQAFVESLKKQGYAKDGTRLPDSTQERDLVGTLQMSAEMALMKMRREEAQKSTDELVKAMLEVRSKARQPEGRRNIHQKRGNGAKDAALKIRRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1Z9</accession>
    <name>A0A3D8T1Z9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein EFR3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_01987</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EFR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1Z9"/>
    <dbReference type="OrthoDB" id="19232at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039786">
        <property type="entry name" value="EFR3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049150">
        <property type="entry name" value="EFR3_HEAT-like_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47766:SF1">
        <property type="entry name" value="PROTEIN EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21072">
        <property type="entry name" value="EFR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="788"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="867"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="976"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="404"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="798"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="868"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="936"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="989"/>
            <end position="999"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW92593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1107" mass="120646" checksum="4D448EF4EB943F11" modified="2019-01-16" version="1">MTKGAVDVKPNSSELSYLLYYATTRRSKVQKVGAFLEKKTASDVWRARIGDVQVTLQILASLIEKAPRDLPLYAPYMLKILNLILRSRDITMVESSIPTFDTFCEHHDGASLAADQEYLIQYEQIVGIYASFASTQSPPSKTPISAPVAVRWRNVGLQAIKSVASADALSSVAGRQLNVIVPILLENMWTGDQAFLDVLLHRLKAEEKTEQEKLTRRRSSYSTVRTVDTVDDANAVALSGTAADVDRVAEEDLGLLAIQCLKQLFVANNRSQIYGSSTATLKFIADRVAQNQPVLEGKTGAPYRGWATRIFEMETRWTPVQDRYVLLVTAMDALVRSPLLENNLQQQLVLTTMVDSLLQSDINLIGLSVMDVLLGLIQHVLRILQLGGAAHLQQESVPGAGQESTDTSASQSAAASTELVTTPSNLRRALLARLQSCIGNLATHIYYADQISDMVSTILFRLKPSPMSSVASSTAAIENSDAATSALAEKVDIVEDSHTDGFFSFGTAKLSALESIKKILLVASSRKKMAGGTLQRNRVQVKVWEGTPWLLRDSDGRVRKAYVDALLTWLNQEMTKSDLKALDDSPKSLMRTNRDDSAIGLSKRAVSNASNHREKPSKPDRTNFLQLLHLAIYENALQFVDSEADIVLLHLLLTSLVGKLGVNAVKHGLPMIFRLQEDIQELERPLAKVRIGSLCHGYFWMLAEIFDFEASAVGRAIQSEISRRQSKGFWVARVRIPPLSLENIGMPGSATGNDIPMDKVETESLLPFDDRFQLVKLISLAYEESLLSPPSSPPTSPGRSFSQPILATTSDKPEPQGSLMPEKIKDQMMLEWTKESVIAHAHESTKTVSLSGSRSGTLAHRNFLAVNGNLNGSNSRTHSPAGQHHGRSRPNSTYGLVGGLGSIRKMRKESGPSPSPASESSRASVTRVDQLKRVLSGQQSGLPNSQAGPTHSDASSDSMVSMDFTVSELSFNPGQENVARAASQQGSNDRARSKSRDRVSSIGDPSPLSSNPTGTAEHPDELEEEVPPVPPLPASLAGETTAVQDHAVTHANRTSRSIKRDSKNRGLPSEKTVWGDDNGVVTDLENLLKGIEVGSFSERGNVAKPPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T225</accession>
    <name>A0A3D8T225_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase S33 tripeptidyl aminopeptidase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_02016</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T225"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="7"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="4">
        <location>
            <begin position="351"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW92622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="487" mass="53093" checksum="E4A1C256F42B5D9F" modified="2019-01-16" version="1">MTDYRGPVFMNPGGPGGSGVFMLIDHGRSLQAIVGKNHDIISWDPRGVGASTPSIDCWSSKQRAQLWSIQAPGVIDSHPGVLYDAFSHAVATSQACAAAMPGPNSLLKFVSTASAARDMLEILDKMGWSRLKYWGFSYGTVLGVTFASMYPERVERMVNDGNVDVVDWTSDGHIHFLADADKVMGAFWKFCHLAGPKGCALYESNPEMIEKRFQNVLNDLRMHPVIVAQAANSPDLPELVTYSSLKRLISAALYRPVLLYPKLASVVASLEAGNGRPFMDLVTAYGMRQPFSCSCEIGGDPGDLEGTDDAFAGIMCSDSGIRIESVEKFESYAKYMMEVSKASGAVNVLFEMSCAGWQIRPKWRYNGPFQGNTTHPILFIANIADNVTPLRSARMNAQGFNGSVVLVQQSYGHTSLTAPSFCTASHIRAYFNDGTVPEPGIECSADIDPFQDLDNLRIMREGGDMELANALYNLTTSFSIRPFAGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T3B6</accession>
    <name>A0A3D8T3B6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_01882</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T3B6"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF7">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW92488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="346" mass="38837" checksum="07DD25462F107160" modified="2019-01-16" version="1">MSMESPLLLNAIIAWSSSHLALRIKSYEPIAIANRCLALQSLSASLSSTTRNPEMELASCLIHCAIESITGDTKEWFNHLVGAYEVIRSVTSSEDTSQLDLSRFSTTFEGRWLLRSFAYHDILMTVVEDRKPLIIAGEYWNFASDALVADSYFGLASRLMYLISRISILNGDMMDCADGSASAESFSHEAQTIQQELVSWTCGQSDNAMLVHLAETYRSAALIHLFRTIRQHRPQLTATLAPRIATQAKEIVTRIEKMPANCLAESSLLLPLFMAGGEVEDPEQIAVIRHRMQDIVEVRQFHNVQAVLTVLEEVWHLRATGVLGPGRRKVDWKDVLARRKWMLSIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T3N3</accession>
    <name>A0A3D8T3N3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Small nuclear ribonucleoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_02002</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T3N3"/>
    <dbReference type="OrthoDB" id="274944at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01729">
        <property type="entry name" value="LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000043">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017132">
        <property type="entry name" value="Lsm7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF5">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037188">
        <property type="entry name" value="U6_snRNA_Lsm7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="42"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW92608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="130" mass="13743" checksum="9C16BCECA5D39966" modified="2019-01-16" version="1">MSERGHQRGGRGGGGRGGSHRGGGGGGRGGAHSSQQERPKKENILDLGKYMDKQITVKFTGGREVMGTLKGYDALMNLVLDDVQEVLRDDEGNQSSRPLGLVVARGTLLVLVSPVDGSEEIANPFVQAEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T725</accession>
    <name>A0A3D8T725_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_00093</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3182339at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022099">
        <property type="entry name" value="DUF3638"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022105">
        <property type="entry name" value="DUF3645"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046541">
        <property type="entry name" value="DUF6606"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051346">
        <property type="entry name" value="OTU_Deubiquitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367:SF34">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13367">
        <property type="entry name" value="UBIQUITIN THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12340">
        <property type="entry name" value="DUF3638"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12359">
        <property type="entry name" value="DUF3645"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20255">
        <property type="entry name" value="DUF6606"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DUF6606" evidence="10">
        <location>
            <begin position="7"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3638" evidence="8">
        <location>
            <begin position="2000"/>
            <end position="2214"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3645" evidence="9">
        <location>
            <begin position="2335"/>
            <end position="2367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2797"/>
            <end position="2827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="2802"/>
            <end position="2813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2816"/>
            <end position="2827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF12359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW94330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="3082" mass="350720" checksum="ED14FFD4CCA228F9" modified="2019-01-16" version="1">MSDLRYLINHVFLPPKRPQASDYSTSNVSSLISSVQKALVAFNNLLHPVPSELENLVKMLDVFKSGTIVSSMDLLPDMRAGELIILHIHNQNAGIIIRRSVTEPAFSFEMFELSPTNEAVTETIGRLTRTFPGPSISLGEDLIRDESFRNELTYLLEKLDSEVLPEATEKVTKARSNAIEVRQTSHPRYVTEMLTAFLRANGHPTTVQRIEKHTRGDVLWDNSLLPWRRSPDWMLIRVALQTTLATLSYSNPHISYKAVMIYFMSKILQLASSQELSSEVLYIMLCKISSRVNKIMASDDPPWLSEVDQITSGVRIQLQTRWAAIEGSTESKIDHPEIEFKEDSWLVDTKLSLHTLGRYLLEMECRRLPQSNHNAFRPDCDQRITASYEVNRIIDNLNIPKSGHSLRLALHDVELWVQENLSTWKQKAKPLTSSCMELAEMFKTYTSKARTVYLGSPEYASRMILTVLEIWIALDISVLEQEPLMKQHRTGFPRPFSKILASLILHTKHDMHRLQMVEGYVVRRDRQAVPSNPSMLSNTTCRNCFAARYFEQSIKHQNLKREIEAAATAERAKKRAEYAEKKKCYADKMQEAQGLLCDTANREVGRVGQRVLETYHPSNCRKCRLKAEANTISIEAHEWPLPGDANEACVAVFELFVPLAIREWRDTTYSITVDLLSPPMTDKFRDPYWLDDFKDLQGFVRTSPGRLRLASQVKPFYRSHFSRPTMINANEDNVCVRHASRYTMMDFQLKCRADYHLDKYNITKICTFQLGAGPLQSLQCFLSSTHQDSNLALASQHKCQTSMTLHEYYSFVSLRAGDTLQWCNIARELIAGVLDFNREETFMLVTQAIWQAGDPDWTVYRRPHRSLEDEVFGMHLISAVNTKLTAVESNWQASRCVRTLTALASRLLSLSPHESVQEKCLKVLQRARDISFQWIREIKILIHSTPDEKELTTLNPRALQLALTCHGTFNVDQSFLIRLLKRSGNIAVITECIITMYNLCPENTNTLSKETQVLIDRSLALSHRVEPLLRAEVLKNREGLDSSISSIWDGYKPGSTWQAMATPNERWLISTVEETSIQSSGDICFNTLNGDLLVNGSPIGRLPLEFQKHATFQRHFSSTLDVVPSSMPGMRFETQLAISGQQVHFVMHKGELIIRTKKGDQIHELLPQSALKHDFPAEFVKNFSHWLNISTGSIEFRSLENTWQPSPNNWQSPEYSLSLIQGHCKLVDVRSTTAKNIARLLEGIEDASNIHTLYHSESSFLEVQLPRLNLDFYVPLHGQNLQSKQFRGMAVDTVQGIGCLTGLRNKLVLSEVKGNARIILVPDGKPSCRNLGNHLQVTIQKSQGRHTPYHTYHVNTLLGRLEDNHNMSSRLFRILLHASTSHCLPDTLTGRTGTEEALYGLSRSSMCSVQELHDRDIELLLTIHKLTPARTYYPPDTDKKVMQTVYWSAMPAMSQHDRFSREVESILKRLKHLYLFQPQSKRPKVESRTSPELLEKAAIRSLFFRVSEFGAQDFTSAHDIVYESRDVHDLSRETDSCHMVKLAMDWSQDLTVCSDLLTTLESLSNKSSSLGGPDKKLSVHIGFDKQMFSPFPDFLANTWGSLHKFLTASNVLRDKHRIMVFLLILRYSQIVDRELCETLLAFATVAALRTLPCPAFSQAKLSDGYQPDRNTILSLFRSNLRGYSNSPESCLPLLPNESAYDAKSRRRKEYDAAVEDSLAKCVDHVMNQWPGPISILPDLEEGICRTHIKMEDAIPTVLDMFNSWRRNIEIQDWAQKVQQILQTLNPSVIGSTKSFSMKTPERQRQVQRGLITFDDLLAASPSHDMETAPKFDLVTTKTRTNPDRSNLDILLGRLSALQTGAYEVKYIQDLRESTDVFCATTTITDELQLETAGAKLAKYQEETNSRMMQSYKELCASLQPRHQGLALSISRNASLWPRISSAIILSHLASPKLKVLSKAWRRALVQYALSISQYQKACRLVACGENISEFLSEINNVGHLDWDPMENPDWLLFEIENNMLIRQDQSQIARQMITPVSGHNSLTQLNMGLGKSSVIVPISALNLADGKQLARIVVLRPLSRQMFDLLVEKLAGILDRRIFYMPITRSMRLSLSNVQIIRKLYETCMKEGGLLLVQPEHLLSFELMGIDQKLFGERALGEIMVKTQTWLDEKSRDILNVKFELIYTMGNQTAIDYSPDRWLLIELVLRKIGDLAPKFMKTFPLGLEVIVGVPGSFPRIRITDQTAGDELLKYAAETICREGLPGVPLQNLSKNERQLVYRFITDPRMSAAEFSPSKDILFSIHTEKMGLLLLRGLFANGVLYYAFSQKRWRVNYGLDPSRTMLAVPYHAKDTPSPRSEFSHPDTAIVLTCLSYQYAGLTNDQVYSSFKQLLLSDQSQQHYEKWTSELVNFPPEFAQLSGINLSNARLCLKKLFPIVRHARNIDYFMSYLVFPKEMKEFSHKHSSSSWQIAKEKQHPTTGFSGTNDSKHVLPSSIEQYNLPHLRSTNASVIDTLLRPENKVDFTYTASHETPGASTILDMAIKIRPRIQVILDVGAQVLELQNEEIATVWLSRVAVDHAQAVIFFDNYNDELCVKNRDGLKERLVASPFVKQMDQCLVFLDEAHTRGTDLKLPSEYRAMVTLGPDLSKDRFIQACMRMRKLGQGQSVILCGPNEVQERILQITGKKRGDTISMIDVLQWCISNTWHLTRKSVPLWATQGVRHYRRQATIAKMGTIEMSVLEKESQSLEQRYSISGQPSEEKVLLHDEMDNILSAYQSEIQDIRQKCRDFGLTTLSDATLQEEQERELQPEQEREQQTETSPAATSRSHSLHPSVQNLAELGDVDSSSEAFLPAFKILLGTTFAKLLDTKAWPQDLLVIKDFLLAIKQDESWVLENEQAELKTSLDFFMRPVHWIITTKTTPIRMVIISPYEANCLLPDIRKYGRVNLHIYSPRLSLSHSTLEHLRFCAIPSVPPSWEPPQNLVMQLNIFSGQLYLRSYAEYTALCKFLGLISHVQGDDTSHKIAADGFVLPNGRSGGYADCQFSKSPIELVRGLISIRRKGQEFITSHMGRILNGEMLKPEDFEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7B0</accession>
    <name>A0A3D8T7B0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Elongation factor 1-beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_00245</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7B0"/>
    <dbReference type="OrthoDB" id="331763at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005853">
        <property type="term" value="C:eukaryotic translation elongation factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00292">
        <property type="entry name" value="EF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.60:FF:000001">
        <property type="entry name" value="Elongation factor 1-beta 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.130:FF:000001">
        <property type="entry name" value="Putative Elongation factor 1-beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036219">
        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018940">
        <property type="entry name" value="EF-1_beta_acid_region_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049720">
        <property type="entry name" value="EF1B_bsu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001326">
        <property type="entry name" value="Transl_elong_EF1B_B/D_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595">
        <property type="entry name" value="EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595:SF21">
        <property type="entry name" value="ELONGATION FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10587">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01182">
        <property type="entry name" value="EF-1_beta_acid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="eEF-1beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00824">
        <property type="entry name" value="EF1BD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00825">
        <property type="entry name" value="EF1BD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Elongation factor 1 beta central acidic region eukaryote" evidence="7">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange" evidence="6">
        <location>
            <begin position="143"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW94482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="229" mass="25244" checksum="FA6A24CC20DC2266" modified="2019-01-16" version="1">MGFTDFAAETGLTMLNSWLTTRSYIVGYQPSQADVVTFKAIASAPDASKYPHAARWYKHIASYTDEFATLPGDASKAYTTYGPEVSEVTLNPAKAPAAEEEDDEVDLFGSDDEEEDAEAARIREERLAEYKKKKEGKTKPAAKSVVTMDVKPWDDETDMKALEAAVRGIEKDGLVWGASKLVAVGFGIKKLQINLVIEDDKIGLDDLQEEIAEFEDYVQSTDIAAMQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7P2</accession>
    <name>A0A3D8T7P2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_00308</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7P2"/>
    <dbReference type="OrthoDB" id="4207724at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW94545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="432" mass="47007" checksum="FC89EF767462739F" modified="2019-01-16" version="1">MGNVLSLNTISGYFVVLTALGGYWYYTTSTSARGARRSLPLKAVVKPVEARKEPKEQTKPRKGKKEGVQSGEDVRLEKAAKKKAAQPAAIESKIDTIPVPTKDTDKDGDAEFARRLSSLKTGTILPSKGQIAGPRQKSVKQGRAQEKPVVVETSSDNATAPSSAAGGDADDDQSPISSPEMKATTRVDDPVADMLQPASPGVSILRITEANGPVRPKKDNRPTAYEAVETKKQRQNRKKAEQKKVALQEQEVERKNLMEKQRRTAREAEGRAAKDGSSFMASKAPSSSAWTAPPANGQNKAQAGAVDLLDTYEAPVNKAVPQATASEKRDSQLNGSGLNDLNPEEEREIRRAIQDSQWEEVKKKPRKTKKPASDLEVSETEKPVKQPTDFGVPPVIKSTGPSQRWETTAPTVEDGEAKEYPKEVQDSEWEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7S7</accession>
    <name>A0A3D8T7S7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA polymerase lambda</fullName>
            <ecNumber evidence="4">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BP5796_00338</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DNA polymerase type-X family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7S7"/>
    <dbReference type="OrthoDB" id="205514at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00141">
        <property type="entry name" value="NT_POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000010">
        <property type="entry name" value="DNA polymerase lambda"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.110:FF:000005">
        <property type="entry name" value="DNA polymerase POL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.210.10">
        <property type="entry name" value="DNA polymerase, thumb domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002054">
        <property type="entry name" value="DNA-dir_DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028207">
        <property type="entry name" value="DNA_pol_B_palm_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018944">
        <property type="entry name" value="DNA_pol_lambd_fingers_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037160">
        <property type="entry name" value="DNA_Pol_thumb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022312">
        <property type="entry name" value="DNA_pol_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002008">
        <property type="entry name" value="DNA_pol_X_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010996">
        <property type="entry name" value="HHH_MUS81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029398">
        <property type="entry name" value="PolB_thumb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276:SF28">
        <property type="entry name" value="DNA POLYMERASE LAMBDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11276">
        <property type="entry name" value="DNA POLYMERASE TYPE-X FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14792">
        <property type="entry name" value="DNA_pol_B_palm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14791">
        <property type="entry name" value="DNA_pol_B_thumb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10391">
        <property type="entry name" value="DNA_pol_lambd_f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14716">
        <property type="entry name" value="HHH_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00869">
        <property type="entry name" value="DNAPOLX"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00870">
        <property type="entry name" value="DNAPOLXBETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00483">
        <property type="entry name" value="POLXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81585">
        <property type="entry name" value="PsbU/PolX domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="12" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="BRCT" evidence="19">
        <location>
            <begin position="180"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="293"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="403"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="293"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="330"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="18">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="369"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile; Schiff-base intermediate with DNA; for 5'-dRP lyase activity" evidence="17">
        <location>
            <position position="530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR622312-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RDW94575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="801" mass="88703" checksum="34A5B93DE4A55072" modified="2019-01-16" version="1">MANPDKAAYFRQLEALSRASDDDDEVDDNDVRSILRNSEPLSISASVSSRIFNSRMLSQRLCTPNLLKKLPPHLSRVESAPTPASSRSVQVVKETPIPRIAALRASFDAATTPASSEPSLIKETPLGPSIFRPRAERRSISTPILGASTSPLALATATVASTTMVNKRKRKVGSITLKPDHELYLKGLVFYYIPPDDTAPARRKQIVRAREHGATWAKELQPDVTHIIADKDLTYKDVMSFLKLNALPADVVLVNENYPLDCCISKSVVNPREIAYILDGFSEVVGPTNEASLVPRTSQRSEMSLELKPAETKPNRWDFVPPKETPPRSEASTQIYGASASPAQNFSEPESSLRLSSGGLGSSLVESLQRATDSPIANNTSSKSPHISGDDLDDLIEKAKQNAHLPLDDTDDDLPASSGAEDIDDSDSEALPTAKRKASQTKMRPYSSRSFKQDSFSCMRGGTGKATSNPNDRTIEIMQEMCDHYSRTNDHWRTTAYRKAIGTLKRQTERICLAEDARRLPFIGQRLADKIEEIVRTDSLRRLESAKAEPTDQILRLFLNIYQVGNSTAWRWIQKGYKTLEDLKEHVDLTENQKLGIEHYDELLQRIPRHQVTELAKIVEEASKMIEPAIKVIIGGSYRRGAATSGDLDCIITMPGTCSSKQLLPFLSKLVNNLTSSGFLVAALAQPSATHGDGSKWHGCCVLPSDPTKTWRRIDILLVPDSELGAALIYFTGDDIFNRSLRLLASKYNCRLNQRGLYKDVLRSDGRFKLTEGSLIEGADEVKIFEALGVPWRPPHERICN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8J2</accession>
    <name>A0A3D8T8J2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FAD binding-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_00652</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8J2"/>
    <dbReference type="OrthoDB" id="1047367at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.400.10:FF:000001">
        <property type="entry name" value="FAD binding domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.400.10">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010451">
        <property type="entry name" value="Acetoacetate_decarboxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023375">
        <property type="entry name" value="ADC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF261">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00590)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06314">
        <property type="entry name" value="ADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160104">
        <property type="entry name" value="Acetoacetate decarboxylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="49"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW94889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="734" mass="80840" checksum="8AFE37067CB91EDF" modified="2019-01-16" version="1">MKQPLEQILNQAKGVLPGTNGLNGTDAASKYSNSACGGNGTVQPASSFKVLVVGAGIGGLTAAIALRQQGHEVLIFEQSKFNNELGAAIHLAPNSNGVLRRLGIFAEDFGANPMQALTEYTPEGECTRHIDLDGPNKMWQHPWLLAHRVHLHDALKKAATRPEGQGKPAELHTSNRVVDVDPEAATITLENGKTIQGDFVIGSDGVRSVTRKKVAGRDVNLFSSGKSAFRFMITRQSALDDPVTAKFAQSPGELIIWYGTDRRIVMYPTTNNTQLNFVCIHPDSESGAGGADTWSQKTSLEEMTKVYEGFDPAMIALISKADKDSLKAWKLMDMETLPTWVRGKLALLGDAAHPFTPHQGQGGGQAIEDAISMAIVFSGDAKKEEINERLNLYEKIRKERAETIQEYSRIAGSDIKAVGQNNMQTYTVYNFGHDEYDNSMQQLRKWFWARNPSMYWRMPIAFGPMPGPRQTHTGVVRQAEQSTFTTASIKFKTSRTVLQNLFPHTSNSYRFKSPGTVAYASYSQTTLGKMEWLGGSGYKHIGLYIHGVEYVKKDGSIISGTYMPLLFESLTDPIVSGREELGMPKLYTSVDIHRRSKGYRINTGWEGAIWGNFVWEGLEESDMAAESGKISGEDDDGILVHRYIPKVGRVHKGEAEAEYPVFVPYAEDFPTPKPQRVYKASKASFKIDPLDVDALPTLHHIISRLAEIPCYEVVSAKVVEGVGVPDVGAAHRVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8Q7</accession>
    <name>A0A3D8T8Q7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ATP-NAD kinase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_00584</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8Q7"/>
    <dbReference type="OrthoDB" id="24581at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003951">
        <property type="term" value="F:NAD+ kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019674">
        <property type="term" value="P:NAD+ metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10330:FF:000029">
        <property type="entry name" value="NAD+ kinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000008">
        <property type="entry name" value="Putative NAD+ kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF11">
        <property type="entry name" value="KINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G12870)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="134"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="143"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW94821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="578" mass="64977" checksum="197104F4FC392BB3" modified="2019-01-16" version="1">MFPAPSPELNIPLNPKHSSDLSPMNPNEEDHGHSSASDSEYQHALEVVFDAQNAHRRKSSLIAADTPRHVFERRKNTECYVHALLESQRKQGRPSHSGLENIAEGLKQRRLATETSESLDIALEKDNALVEVKGSDADASGQEDEKAWKERHSAQAEQKVEVQEGDDSTAVHSRLLTKKQLSDMAWGVRELSKRLGKIRLKLKVKTVFLLTKAHDETLIGNTRDVAKWLLSPERDVKYTVYVEENLKDNKKFDAEGLMKEIEETTSSQEGESNGVTKSASKRLKYWSNTMCRTRPHNFDFVVTLGGDGTVLYASWLFQRIVPPVLSFALGSLGFLTKFDYDKFEDTLTTAFRDGVTISLRLRFEGTVMRSQQKNTKAITDGEEGIVKDENHHRRDLVEELIGEEKEDERTHRPDGTYEILNDIVVDRGPNPTMSSTEIFGDDEHFTSVQADGVCVATPTGSTAYNLAAGGSLCHPENPVILVTAICAHTLSFRPIILPDTIVLRIGVPYDARTSSWASFDGRERVELRPGDYVTISASRYPFANVMPQGRRSEDWVNSISGKLGWNTRQRQKSYKEWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8W2</accession>
    <name>A0A3D8T8W2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_00766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8W2"/>
    <dbReference type="OrthoDB" id="2245989at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF1">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW95003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="32452" checksum="250DE178274EABC7" modified="2019-01-16" version="1">MEGPLSLCIHAEDWTGRADRATRRKIQNRLSQRARREHKSRATHPQATRGSAPVDGPKGVTGVLKVRNDSIVRYFISDRHLGSELNPQSSQLPMALQNPTAGLPAVEQQVAHWMLYWLHKAPIDDSNRGALIHLEYTLSAPETLCVLPADHLLTLVHYNVLRAFVSNALCLGLDPKRICFELSSPFTSSDHRTIRPPPPALYPTALQQTRAHHPFIDIFPSATARDNVLSAAGDSFDEDEMWRDLFGTRFLRGNVGVKENVGLVVWGDPWRVESWEGSLGGDEFLEEGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9Q5</accession>
    <name>A0A3D8T9Q5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ELMO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_01017</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9Q5"/>
    <dbReference type="OrthoDB" id="28413at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017124">
        <property type="term" value="F:SH3 domain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024574">
        <property type="entry name" value="ELMO_ARM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF56">
        <property type="entry name" value="CED-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11841">
        <property type="entry name" value="ELMO_ARM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16457">
        <property type="entry name" value="PH_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="2" id="KW-0581">Phagocytosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0729">SH3-binding</keyword>
    <feature type="domain" description="ELMO" evidence="6">
        <location>
            <begin position="255"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="260"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW95254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="729" mass="82038" checksum="A0B457FAE759C438" modified="2019-01-16" version="1">MDQADIPALLSRLSSDEDAMRKMAVFKLQSSINDPAFADVFISSGGLVILRRLILTTGGNTLAYSLQSLSRLLEVDMGWAIFETTGAGELVERLVELIVTHPLVNILRGAMSILVAVVSYLQSSRGTTRTPGAFGFRALKPGVAVYPQFFEMVVSQLNSADHALCANALMLLNALIRDAVTSDSKEGGGKSSGTGEEWPKFIKRLQDLGVIKAVYILMQSSALQDLAHPLLEFQALTKVLLRKWRDVRVDLERPEHRRALKGLHLSSAPERRQNLDPGTPKLEEAPPPPPPGGRKGSKRHNPEKWRRLGFETESPAWEFDTTGFLGMMDLTDYVRKQEDGFQKLLLEQSTKPMHERCPIARASLAVTLILYEHFEVDKSDVEDAKAYLVLDGMKNYDKIFRPQLLQWSRLHTASLQAFFRLWKATGATQDDFEKVADLVSILIEQVVGQASRTKDVQEVEEELFEFEYSRLRELQMEILELTFEEQWGHHLYQVRDELKHEALQFVKEQRIRCLLQGAWFPKMTNLQNTNDEGAVGKLGAKKHLPWRYVKLSHNRRYLHYSDFEIQPALEPLLEQLQEKIDLSTISSVVSNVSASHDDTSSMSSMSTLKDISQTPKQTSTTKITINSFVNPHDDGLQISHSDEPAERAILTLLPPTHSLASEWLDGLLMLLNQAPITAETNKLVGLVSDYGLKIRLLNMRVDDGYAGQPEGSGIVPSREGLDEDYYYEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q3G1</accession>
    <name>A0A3D8Q3G1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_13168</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 3-beta-HSD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000027">
        <property type="protein sequence ID" value="RDW56419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q3G1"/>
    <dbReference type="OrthoDB" id="10058185at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006694">
        <property type="term" value="P:steroid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002225">
        <property type="entry name" value="3Beta_OHSteriod_DH/Estase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050177">
        <property type="entry name" value="Lipid_A_modif_metabolic_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245">
        <property type="entry name" value="BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43245:SF51">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01073">
        <property type="entry name" value="3Beta_HSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="3-beta hydroxysteroid dehydrogenase/isomerase" evidence="4">
        <location>
            <begin position="7"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW56419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="219" mass="24349" checksum="9D83BB3C8D7941D8" modified="2019-01-16" version="1">MPLCFEPEQKEYYTPTKAVAEEIIHTAYGQNGLLTTIMRASMLFGEGDTTSTPQIVQNARAGRGKFQIGDGLNLFDFSYVGNTAYAHILAAKALVRESNAADPIAEDSEVNGEAFVVTNGEPCPFWDFTCAMGAAAGYPVKKEEIWIIPATMYCLFGIVFDWTVWIISLGRRESIINRRMGKYLTMTRTFDISKAKERLGYAPQVTMQEGIDRAACDIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q4Q6</accession>
    <name>A0A3D8Q4Q6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Class II aldolase/adducin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_12859</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000024">
        <property type="protein sequence ID" value="RDW56792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q4Q6"/>
    <dbReference type="OrthoDB" id="3238794at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.225.10:FF:000009">
        <property type="entry name" value="Class II aldolase/adducin N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051017">
        <property type="entry name" value="Aldolase-II_Adducin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004855">
        <property type="entry name" value="PRK06208.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672">
        <property type="entry name" value="ADDUCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10672:SF41">
        <property type="entry name" value="CLASS II ALDOLASE_ADDUCIN DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_3G01330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="2">
        <location>
            <begin position="53"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW56792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="297" mass="32296" checksum="E12761C9C534AB0F" modified="2019-01-16" version="1">MAPSATEAAPDITSKTEGKEYSSGNPDLCFPTDVPTGPPTFEDKYEERKYLKHRLALAFRVFAKFGFSEGVAGHITLRDPVDPNSFWVNPFGLHFSLVTDDDLILVDHTGMVIDGGRNRMLNYAAFAIHSEIHTARPDVNCAAHSHSVFGRAFCSTGRTLDMLTQDSCVFYKDHALYDNFAGVVLASDEGKHIAKALGHRKAVLLGNHGLLTAGKTIEEVVAYFVLLEKCCEVQLAADASSGGTGKPLVKIGENEAQNTWEALGHSASGYFQGLPLFQTVEAEFGERTFLGRGLEPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q589</accession>
    <name>A0A3D8Q589_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PEBP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_13039</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000024">
        <property type="protein sequence ID" value="RDW56972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q589"/>
    <dbReference type="OrthoDB" id="10251855at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00457">
        <property type="entry name" value="PEBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049556">
        <property type="entry name" value="PhiB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289:SF1">
        <property type="entry name" value="PEBP (PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30289">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBCL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW56972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="213" mass="23903" checksum="5498915F9998F485" modified="2019-01-16" version="1">MGLLSTILKYVEYALGKLLISRRGYDDGLFSRTPAFRKCPEPTIQLSSLDCGPSYSRLSHDYSMFGKGLMPTLTWPEANENIREYLVIIEDVDAPFGGKPNVHGIYALIPPSTTSLSPHDLETVDTDVKGQHRLKSGFRVGKNRRNVVYIPCRPPLGHGPHRYFCELVALSEKLDPDTLSPVPTKEELAELVKGKVVAWGEWVGVYESDWNER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q6I3</accession>
    <name>A0A3D8Q6I3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12737</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q6I3"/>
    <dbReference type="OrthoDB" id="5376804at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021514">
        <property type="entry name" value="DUF3176"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394:SF5">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11374">
        <property type="entry name" value="DUF3176"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="500"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW57287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="589" mass="65054" checksum="75BDA74411B226AA" modified="2019-01-16" version="1">MATPRYKVLSQSFESPNYPTNVARYPVSTPSTAARLRFEGIQQPYLIAQAPKSGFTVAKKAISKPHVWDDTWVFELLCLITSALALVGTVIVLKYYNGHPIPIVLPYDVKLGSVLAVLSTVMRAAIGVFLAAGLGQMIWSQFRQGSRPLSDVSLFDDASRGVTGGITLLWSRHGNWRSTIGIFCTLLVFAIGPTIQGTLGSEYTTGLSTLPRCTGNHSAAGNGFTVENMGTLFNQYQASIFLSTFDPSGPSDETLQSLNTNCATGNCKWPVFASLAICSNTTDMYDQTIKNYDSDGSVASLTLPNGLSVPKIGGNPTYWNGSITFPTINYNDWRYDPIARFSVLFHHNDLHGSGMPDYRSAEGIMYWCVQSYEASVTSNILSSKIKSNWWPDYMNNSAETQVLSPPDEFWKDSGITEPTDFTVHRSMTRWLPFFNLSVDINNTKYNPPNQLQIIAGFSVASLPDFFTYLASAMTNRFRGTICNESVDGTMHELQVLKVQWYWLILPCASIVFTFGFLLAVIADSWSQGAMIWKNSILPILFHGLSEDIRKNKGTGNVASARTMKNQAKSIHVQLKENDADYAGLLLRSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q6W7</accession>
    <name>A0A3D8Q6W7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_12838</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q6W7"/>
    <dbReference type="OrthoDB" id="5376287at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW57388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="483" mass="55370" checksum="E33B59B5219C4582" modified="2019-01-16" version="1">MPSRTSTIFGKWFEMPRRADMAGLDGCSGKPSEILFISSSDIEKADPTTRKLIRSHVMRGRKWKTSGPSKVQRVPIRRTMAARTPAVQVQLQELFDKYTQLVPGRVGSDFSCIDFPISPVASKVIFPLMAAISFQRDNQGWLYLIDVDTAALHITIFAIESFIDRILRHQVNRVNLPARLHFQEGLRLLRERLLGDDDDTRISDSTMGVVLKLAGAAHFDGDYATAKHHMEGLRRMVDLRGGLDVFQGKYLLAEMLRCDLGIAILNGSNPVFYCRPTEPVINYPERLLLASNDKICFDDNIDMIQNMDHDLAIAWQVIRRFCFMVNVGTQTQRLMAPEFVYETMTAVIYRLLHMHFANNSIAEAIRNGLLAFSYHIFLQWQDIKLPYDYFATTYKDCILGLKDIDGISSQLVLWLLMTGANAVFNIPNEAWLRDCLREYTHKCQVKDWKEMRGILKSLMWIELLGEQPEKQIYNLLQLDHGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q8J1</accession>
    <name>A0A3D8Q8J1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_12555</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q8J1"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000117">
        <property type="entry name" value="MFS hexose transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="347"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="32"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW57754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="527" mass="58892" checksum="C1E65A0904EDFFF9" modified="2019-01-16" version="1">MVHEISPTLKAVLADRKVGYFADKGLTKLNFILILSLLSSYATGYDGSMMNGLQSLDEWKGYFNQPGAHTLALLNAIQNVGQLITIPFAAYSCDQFGRKPVLIGSAFILLIGVILQAAAQNVGMFIGARCILGVGLGFNITAAPLLIIELAFPTHKSQMVSLYNSLWGSGALVAAWTTYGSFRILNTWAWRLPSILQALSSIIQICLFWFVIESPRWLISKERYDEARDIIIKYHANGNPDDPIVDYEMQEIRAAIQIDLEQQQNNSYLAFFHTTGNRRRFFIILAVGFFSQWSGNGIISYYLSLVLDSIGYTSQDTQTLINAILTIYGLVIGIIFAFLCDFWPRRTLFLFSTAGALASYIVWTGLEATYEKQTGLDGVGNAGIAKGVLAIIFIYNFFMAVGWGPLQVTYVVEILPFHLRARGLVLYNFFVDLALIFNQYANPVALTNIKWKYYIVYDVWLFVECLVVYFLFVETRGASLEEVSFIIDGGSIQEELLEHTSRHLEKDPVSPAVVIEKGESGEDIKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q8Y7</accession>
    <name>A0A3D8Q8Y7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_12201</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q8Y7"/>
    <dbReference type="OrthoDB" id="3172332at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF4">
        <property type="entry name" value="HYPOTHETICAL CONSERVED PROTEIN (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW58271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="363" mass="40595" checksum="EF07AD48ABCEC72B" modified="2019-01-16" version="1">MSSILASSNQELTIEQSSRGVRGRKPLFPPFPIHHRHGHGRCLGLGPVELPGAAEQPPRIICVAFHCCYWCFAIGALLKSLETAYAAVEDEIVEAFQSLDIQIIGLKDGLSTACHEETTENHDITIASLPTSFSNVRDAQIYLTHIVRRSYHFIGTVLTYLPSTSATVQQRDGELAGDFFMSRTMNSSRPFPNTDTMRTQQAQLATETAAWMHAFAPDVPTPCAYNAAVMMQMQTITTTILIAGVAMTNEMEYDKFRPQFDELVALATAVIGLRQQRKKDRVWAGGFWVDIGITPQLLVVVTRCRDTAIRRQAIALLEGWYIEGGWDPRLVAELGLFMIEVEEQEIERVMKFNAEQDENRIMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q940</accession>
    <name>A0A3D8Q940_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_12266</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q940"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="338"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW58336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="885" mass="101564" checksum="06D393A0C02CE870" modified="2019-01-16" version="1">MTIVVNPATDMDNIQLSRTALARIGGAPLRRSADVLAPQAMDPVIGAPEAYRASDEHDAVTPGSTAGTEHAENPEQAREPSKSRSPDRKRMSIGPQILFILSQEKTEEYVAKIRTKLSSTSDNWALAKLLWHYAEEWATSEVTKENFQGYLSTTQLHSYALLHDWIHSKYELEAVIRPFSRSLYDMETDALIHEALDDDDSHVLKEEYRQITLYQKVMADLFRIEFSPNHWVGEHYRKRAHHGIDFQGDEFETIDYLRLRAWQVGTAQRISWKFTSVSWNDGLNMSSKSKAFENPSRRIDYCPWLKRDKSRSGFPRYLWDIAQKKTVDTSEFPIRVEYTCISHTWGRWRKKEWVTMPGVPWRVPSNTRFDIEELPTTFYNMKDRFTTNFIWLDLFCMPQETTDPHFLSILKAEIARQAVIFQNAIACVAWLNYINHWVAEYCTIGWLSAQFVTLGSRPGMSNAESILRAADHGCYLPLQLTRLSNPTFGYPKWRALLIQVANDLDEWWRRKKERGPYYHFEPSDWFSGVWTLQEAYLRPNMVLADKEWNVLSDASGEPISLEELFALDSVVWQLRTWGTQVLGGFIIEGHGVEDWPFDDTMQVHACANPKYGCPPGPQQLHAMIKKTHLFPEGPGSRLDPLIQANARYCTAGATGRAEAIMSSLGVTDWFKADAAVHEKDLVLGMYPVRFLQEALLSIGPDFFRTSVDDPSIWPALNPLTRRTGSMMPFHRYRTNHPRMKSIKTRGSLPYHDPSALDPSVRTWQIQSNGSVVISQAVIFASNRPEFPGIEGLGLAYLTFWGPLYSKSDVYEFSEWVEQQPRFLDTFVVPITRPNPFKVVGLLLQGRTLRKKTRLVKIGTFELAMIGITESPETWSKVEKVDWIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q9H8</accession>
    <name>A0A3D8Q9H8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EamA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_12406</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q9H8"/>
    <dbReference type="OrthoDB" id="306876at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911">
        <property type="entry name" value="ACYL-MALONYL CONDENSING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22911:SF6">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="34"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="207"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW58476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="374" mass="40482" checksum="FF2B86894C210DC7" modified="2019-01-16" version="1">MSDPSGDNPAPQADSVPLSPPKPSAWRSVWQNNKGMLLILLAEIVGSSMDAIVRFLQQGGHGMHPFQVIFARMGMTFVLSSIYMWWTKVPDFPLGNPAVRGWLILRSLFGFFGLFCLYYSVHYLPLAEATVFRFLAPIVTAWACSVFLTEKFTRQEMLAGLVALLGIVIIAHPAGIFGRVEDNIDTGKGDDVDNVTSAQRLFAIAISILGVFGASGAYTTIRVIGNRAHALMSVNYFAILGTVGSAVALLVIPGIGFTMPHGPREWTLLLLLGVLGFVLQFLLTAGLQLDRSSKATSMMYTQVLFALAFDWGIWGVLPSRWSLFGGAIVIVSTLWSALQKNTIAASPTKTITDEESPLLGENNGALDRRASIGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QHL6</accession>
    <name>A0A3D8QHL6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome P450-14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_11218</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QHL6"/>
    <dbReference type="OrthoDB" id="6692864at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902181">
        <property type="term" value="P:verruculogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000063">
        <property type="entry name" value="Cytochrome P450 monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF187">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="508"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW61326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="565" mass="62932" checksum="0717C12AE991E88D" modified="2019-01-16" version="1">MGTSPLVLAALLGSVFGVTSHLGYFIHGEHHMQSGRILLSFLFGPILIFIGILRLDSSSSAAIAAKLTTITSVSYFTALSLSILTYRIFFHPLRNFPGPFSAKLSKFTHVLRVAKDSDNFRRANELHKKYGEIVRVGPNELSIIVPEAVPAIGGSGSKCTKSAWYDVVGIPHKSLHLCRDRVAHDKRRKVWDRGFSAKALRDYEGRVTSYAGDLIKQLTTSAGKPFNASLWFNFYSFDVMGDLAFGRSFDMLKNGEQHHALKTLQEAMAPLGILSPLPWIFPMVHHIPGARDGIKGFIDFCDEQIDKRREVRPQFPLMIYAHRLIWSIQKEPEVPDIMSWLIDAEKSSNDPIHKDPDWLHGDARLVVVAGSDTTASTLTYICYYLARSPEIVASIRNELKPIYQAESPTESKDIQDAKYLNGVINEALRLHPPVPSGLLRQTPPGGITIGSTFIPGDVTISAPTWTMGRLESCYQNAEEFIPERWGDRPELIHDKAGFAPFSAGPYSCIGKQLALMELRVVIARIITQFDVSFAPGEDGTNLMTKTRDVFTLDMAPLMMVFTKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QHR4</accession>
    <name>A0A3D8QHR4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_11237</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QHR4"/>
    <dbReference type="OrthoDB" id="2094269at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005645">
        <property type="entry name" value="FSH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050593">
        <property type="entry name" value="LovG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48070:SF6">
        <property type="entry name" value="ESTERASE OVCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03959">
        <property type="entry name" value="FSH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine hydrolase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW61345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="273" mass="29444" checksum="E96F740656D82066" modified="2019-01-16" version="1">MTNPTSERKLKILMLHGYTQNGPLFHAKTRALEKLLNKAFPASKASPIAAQYPGGVQLIYPTGPIRLQAADIPGFDVNAAGGEEREAFGWWKRETGSGNYIGLNDGLGTIAATIKAEGGIDGVIGFSQGAAGAGFVASLLEPGRVEAFAKREPQGGIEYPEAFELGQVNPRGMLKFAVSYSGFYAPNEAYRAFYEPKIATSMLHFIGSLDTVVEESRCLALVKACEKETVIYHPGGHFVPIGKEMAGQLIGFIKECCSEKKVEESVEDMDMPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QIE9</accession>
    <name>A0A3D8QIE9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_11393</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QIE9"/>
    <dbReference type="OrthoDB" id="4841197at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.140">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW61501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="166" mass="18670" checksum="5E403DE278DCA8C1" modified="2019-01-16" version="1">MDQVQKSFNDIERKLTKMGKIREKGGSNLGMKDVMKMGQKGMSVEKIMKKIVKEGNNMNPTEIEAEKMLETMERITDLTCMQMQFALDNKPMFEKLHLAGMVKKNMGKSKQTGVALSVLLIEKSPVYLKPKAEKLEQRSQAQFAVTMAAFSNATGGEEKELQDDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QIG6</accession>
    <name>A0A3D8QIG6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amidoligase enzyme-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_11518</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QIG6"/>
    <dbReference type="OrthoDB" id="412402at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022025">
        <property type="entry name" value="Amidoligase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847:SF1">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12224">
        <property type="entry name" value="Amidoligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW61626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="58357" checksum="0BBAE9307A1E6A68" modified="2019-01-16" version="1">MSSIQTGEKTAIVSKVNESISVKPPRGITYGIELELVFAFHESELRNNPSPALSPDMEIAKDLSLSLRRTAAFTNIRDTPLHIYNSWGKRPKHDSFAVPAPYTTEPQQILFDHLTNNDLMARFDIRDTMTWGEKAHQDYKRWLITKDYTVCGVGSHNLPEWLPNIVNASNHPKRGQASWDSIGLEIVSPVMHTQRAENRREIEEVVQALQKPANGTGVFITNQCGFHVHVEAPTDLKVLKTLALLILVYEEEISRLHPPCRQPNHPCASNNLESNRQMLTTKHRSDNETTPVVGKADCSIKALRSQLGWKELVQCFDDYVPEDDDIDYNLSRFMNGPATGLEPLGARGRLVNFTALARHLMPSEAGRARTVEFRQARGTLDHNDIAHWVDFCTGLVQLAHALSGDESRFSARFEGWDDLFSSGPGKKKGIDVFDLMADMGPCSESIRYWVERVERYQNCEIGGPLDRTDLEDEVASLKRDGDWAGDEEDDFVLHDDYEEDSRCGKIDKRVFANKVAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QIT5</accession>
    <name>A0A3D8QIT5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pectate lyase</fullName>
            <ecNumber evidence="10">4.2.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_11472</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Eliminative cleavage of (1-&gt;4)-alpha-D-galacturonan to give oligosaccharides with 4-deoxy-alpha-D-galact-4-enuronosyl groups at their non-reducing ends.</text>
            <dbReference type="EC" id="4.2.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3 10">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the polysaccharide lyase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.2" evidence="10"/>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QIT5"/>
    <dbReference type="OrthoDB" id="441042at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004898">
        <property type="entry name" value="Pectate_lyase_PlyH/PlyE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33407:SF9">
        <property type="entry name" value="PECTATE LYASE F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03211">
        <property type="entry name" value="Pectate_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5025092963" description="Pectate lyase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="46"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="88"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW61580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="388" mass="39386" checksum="B4895D4CFB4C6866" modified="2019-01-16" version="1">MKFSNVQLAVLAVALGVSARPAEHGPNVVARVNGARSPFFDLVERKPAGADQPRRSFGSANSPFDNLKVRKTSKSKTTSASDSEETDAASSDDSSESSATDSSSKATSTGSSKSGSTGSTVKSSAVASKTASSGSSKSSGSTKSSTTTAVSSSGNSTGSTSGSLPASSGSSALSAVQTIAAGESFDGGMFMYDRGTACEGQTEGGDSAAVFQIEAGGSLSNVIIGPNQMEGVHCQGACTLTNVWWSAVCEDAFTIKNQDAGDTTYIKGGGAFGADDKVLQHNGGGTLSVSDFTVETFGKLYRSCGNCDTMYERHVIMDGITATDGTELAGINYNYGDSATFTNIVASGVDDICVTYTGTDDNSQEPSEYGSGADGTYCIYSTSDISSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QIX5</accession>
    <name>A0A3D8QIX5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase M3A/M3B catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_11512</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="7">Binds 1 zinc ion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QIX5"/>
    <dbReference type="OrthoDB" id="534666at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06455">
        <property type="entry name" value="M3A_TOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.390.10:FF:000006">
        <property type="entry name" value="Thimet oligopeptidase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1370.10">
        <property type="entry name" value="Neurolysin, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024077">
        <property type="entry name" value="Neurolysin/TOP_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045090">
        <property type="entry name" value="Pept_M3A_M3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001567">
        <property type="entry name" value="Pept_M3A_M3B_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804">
        <property type="entry name" value="PROTEASE M3 THIMET OLIGOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11804:SF84">
        <property type="entry name" value="SACCHAROLYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01432">
        <property type="entry name" value="Peptidase_M3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M3A/M3B catalytic" evidence="8">
        <location>
            <begin position="158"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW61620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="655" mass="74426" checksum="263196E9C9B4E069" modified="2019-01-16" version="1">MQKPPQAPPLFNGTPGSIVVDARAVVENKRKVQDQLVQAVRPDHATFANVIQPLANAENGLHAQSHMLGFYTDVSADPELRDASAEAQRLFNDFAIESAMREDLFALVDAVLGKQEDLRLDGISSEIISDLEKGTGENEGKLRLTFEFHHLIPAQMFAKDGEIRKRCTLGYENKCNANIPIFKEVMLLRDEAARLLGYPNHATFRIEEKMAKTPETVNTFLEDLRSRLASGGQKELQNLIQLKRADLESRNEPFDGRFFLWDLAFYKQIMLEQQFSIDQQKIAEYFPLQTSIDGMLEIFQHLFGLTFVEIEENKRNDLAESGNGGELVWHEDVQLFAVWDDVEEGGGFLGYLYLDLFPRDGKYGTPANFNVQPGFCRADGTRQYPSTALVCSFTKPTAETPSLLRHDELVTLFHELGHGIHDLVSKTLYARFHGTMMVIDFGEAPSQMLENWCWTPSTLQSLSRHYSSLSPRYLETWKARSEGGEPVPPVQIPDKVINKLIRTRHVNGALFQLRVLQFSIFDMMVHEPTSHEALERMNMSVEYNKLRKDLMKIDGPEVLGEDYEWGHGEGNFGHVMGDYDAGYYGYLYSQVFADDIFHTVFQADPMNAQEGRRYRYGILEKGGSQDEMKTVMDFLGRQPSSDAFYRELGLVEPPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLN0</accession>
    <name>A0A3D8QLN0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_10920</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLN0"/>
    <dbReference type="OrthoDB" id="5571754at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3370:FF:000001">
        <property type="entry name" value="40S ribosomal protein S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_eS24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053709">
        <property type="entry name" value="eRP_eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_eS24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018098">
        <property type="entry name" value="Ribosomal_eS24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00529">
        <property type="entry name" value="RIBOSOMAL_S24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="97"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="106"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW62618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="133" mass="15206" checksum="8ED8793A6B645461" modified="2019-01-16" version="1">MADQPVTLRTRKFIRNPLLGRKQMVVDILHPNRANISKDDLRAKLAEMYKASKEQINVFGLQTQFGGGKTTGFALVYDSPEALSKFEPHYRKVRVGVASKIEKPSRQQRKQRKNRQKTLRGTAKVKGAKKKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLX8</accession>
    <name>A0A3D8QLX8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">p-loop containing nucleoside triphosphate hydrolase-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_11138</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLX8"/>
    <dbReference type="OrthoDB" id="10265467at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18139">
        <property type="entry name" value="HLD_clamp_RarA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3710.10:FF:000005">
        <property type="entry name" value="AAA family ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000001">
        <property type="entry name" value="Putative AAA family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000137">
        <property type="entry name" value="Replication-associated recombination protein A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3710.10">
        <property type="entry name" value="DNA polymerase III clamp loader subunits, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032423">
        <property type="entry name" value="AAA_assoc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051314">
        <property type="entry name" value="AAA_ATPase_RarA/MGS1/WRNIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021886">
        <property type="entry name" value="MgsA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006642">
        <property type="entry name" value="Rad18_UBZ4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779:SF7">
        <property type="entry name" value="ATPASE WRNIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13779">
        <property type="entry name" value="WERNER HELICASE-INTERACTING PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16193">
        <property type="entry name" value="AAA_assoc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12002">
        <property type="entry name" value="MgsA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00734">
        <property type="entry name" value="ZnF_Rad18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBZ4-type" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="180"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="28"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="33"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW62836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="596" mass="64747" checksum="A8FE55A0E6F4180F" modified="2019-01-16" version="1">MVECPICSKSVKSRDINNHIDSGCASFIDDSPPATQNGTSQPAATQKPAVSSFFQTPAAKRGSAYPTPKIEPSPTLSFHQKPQSNGVGSITPSQPQRKRSFEDVASTAGIKEEGGSALRLETGAPRQENIEPAAKKPKTNAFQKVAPLAERMRPRKLDDIYGQELVGQDGVLRGLIEEDRVPSMILWGGPGTGKTTIARCIASMVGSRFVEINSTSSGVGECKKLFADARGELSLTGRKTIIFCDEIHRFSKSQQDVFLGPVEAGQVTLIGATTENPSFKVQNALLSRCRTFTLQKLTEEDILKILEKALAVEGPRYGILAKEPEMSKPESPIPENDMEVEGAEPGAPEKMLKAEDTSAPLIDGELLSYLSAFADSDARTALNLLELAMSLSTRPSMTKDGIKSALTKTLVYDRAGDQHYDTISAFHKSVRGSNADAALYYLARMLQSGEDPLYIARRMVVIASEDVGLADNSMLTLATSTYSAAATIGMPECRINLAHCTVALCLSPKSTRTYRALNNAYAALREPGVASLSIPIHLRNAPTKLMKELGYGDEYKYNPNYKEGKVVQEYLPEQLKGRRFLEDRDLGTEIDPGAWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QM22</accession>
    <name>A0A3D8QM22_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Galactose-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_11053</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PITHD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QM22"/>
    <dbReference type="OrthoDB" id="2635at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.470:FF:000003">
        <property type="entry name" value="DUF1000 domain protein (AFU_orthologue AFUA_1G09230)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045099">
        <property type="entry name" value="PITH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175">
        <property type="entry name" value="AD039 HT014 THIOREDOXIN FAMILY TRP26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175:SF1">
        <property type="entry name" value="PITH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="3">
        <location>
            <begin position="23"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW62751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="221" mass="24456" checksum="E23B13885D375198" modified="2019-01-16" version="1">MSSHCHDEHDHSGHSQHDGHDHSDDLTPALQYSLYQHINFDEITTLNESQAHSGKAIVKKTWAERMQEEPALESDADEQLLLHIPFTGQVKLHSILIRSSPADSAPQTLKVYINRDDLDFSTCGDLPPAQEFSLSQTSEIQDIQVKRALFGKVQSLTLFIEDNYGEDTTLLSYLGFKGDWMQLGKAPSNILYESAANPADHKLKGTEVNKMGSGLGGGRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QPW4</accession>
    <name>A0A3D8QPW4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SUI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_10351</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Additional factor that functions in concert with eIF-2 and the initiator tRNA in directing the ribosome to the proper start site of translation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW63849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QPW4"/>
    <dbReference type="OrthoDB" id="10248435at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11566">
        <property type="entry name" value="eIF1_SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.780.10:FF:000005">
        <property type="entry name" value="Sui1 translation initiation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005874">
        <property type="entry name" value="SUI1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10388">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="SUI1" evidence="6">
        <location>
            <begin position="29"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00060093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW63849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="122" mass="13986" checksum="D21907372D74FB58" modified="2019-01-16" version="1">MPSPLVALGHPFAEADEDTGETKQSQNYIHIRIQQRNGRKTLTTVQGLPKKFDQKKILKVIKKKFACNGTIVVDTEMGEVIQLQGDQRKDVQEFLTDKKEGLELDAKTIKARLKYFLKLRLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQC7</accession>
    <name>A0A3D8QQC7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_10423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW63921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQC7"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW63921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="215" mass="23670" checksum="6631009199ECFC47" modified="2019-01-16" version="1">MDRWVDSAPSEVASPSSSCTAKPHREPQKTFPIPASGILFFGASRKLSSMPCHAMTRQPTSSCKPTSPPLISTPLHPAPLVRALPHPSQNTTSQSSSGANSCYQRDEGFTAAVSMCIEAIQRNEVSRNWSKQTLSRRHRCPAAQQGGVRQERSHSPDSKVLRMLDLPRDALTNQAPTLEIRWRKKEKQNSAPTKQTTKWSEQEQQVGSNAGAGWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QR25</accession>
    <name>A0A3D8QR25_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="6">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_10620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="6"/>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QR25"/>
    <dbReference type="OrthoDB" id="4699125at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000005">
        <property type="entry name" value="Phospho-2-dehydro-3-deoxyheptonate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DAHP_synth_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009395">
        <property type="entry name" value="PRK12755.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225:SF18">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, PHENYLALANINE-INHIBITED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 6" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP synthetase I/KDSA" evidence="7">
        <location>
            <begin position="57"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW64118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="375" mass="40508" checksum="C4906B69D61591AB" modified="2019-01-16" version="1">MASSLIPNPNVGNKNDTEDWRIRGYQPLTAPDFLQHEIPQTVKSKETVLRGRNESVEVVTGTDANQRLLVVIGPCSIHDPPAALEYCDKLLALKEKYKDDLLIVMRSYLEKPRTTVGWKGLINDPDIDNSFNINKGLRTSRKLFVDLTEKGMPLASEMLDTISPQFLADLLSVGAIGARTTESQLHRELASGLSFPVGFKNGTDGSLGVAIDAIGAVRHPHHFLSVTKPGVVAIVGTVGNEDCFVILRGGTKGTNYDAKSIAEAKAALQKAGVRERLMVDCSHGNSLKNHKNQPKVAATLAEQIEKGENAIMGVMIESNINEGAQKVPKEGKAGLKYGVSITDACIGLDDTESVLEMLATAVAKRREMKKANSNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUZ7</accession>
    <name>A0A3D8QUZ7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NADP-dependent malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_10281</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the malic enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUZ7"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000182">
        <property type="entry name" value="NAD-dependent malic enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF32">
        <property type="entry name" value="NADP-DEPENDENT MALIC ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="10">
        <location>
            <begin position="164"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="9">
        <location>
            <begin position="353"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="19"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="258"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="329"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="501"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="549"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW65589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="654" mass="72581" checksum="7287D29575238242" modified="2019-01-16" version="1">MSAAYNYSTSVSEAATPRSSSPASMVSSRSSTSDSTKRMSISSARRMTEQNPLSSIDIQTLEANMRAQSLDTLRGYATNHYGEVHQDRPTEYVSKETATGYQVLREPAWNKGTSFTPEDRLKRNLSGLIPHTMETLETQCARAMKMINSRSTNIDKYLYLSSLKSTNTDLFYRLLIDNVEQLMPLVYTPTIGDVCLQYSTLYTRPEALYISIKQRKSIATLLRNWPYANPSICVVTDGSRILGLGDLGVNGVGISIGKLALYTGAAGIHPEKTLPIVLDCGTNNETNLHDPLYLGLRQKRVSMADQQDFMDEFMAAVKQVYPNMLVQFEDFDTEKAFGYLERYKKEKCFNDDIQGTGAVVLAGYIGAVNLSGVPIEDQRLVFMGAGSAGVGVAKQVMEYYTRRGLSEQQAREKFYLVDTRGLVTKDRGDKLAEHKKIFARTDNNGHQFDTLEAVIEYVKPTALIGLTATFGVFTESVVRALKVSVDAGGMGRRPILFPLSNPLTKAECTFEQAINWTDGTAIFASGSPFSPYTTKKGDSVTTYYPNQGNNVYVFPGLGLGAILAQCSRVTDDMVYTAAAALSGCLNKEEIQMGLIYPKVQRVRDASVVVAREVMKCARRDGVSTLPEETWVEWEEWGDVALTKWIQKQTYDPKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QXW8</accession>
    <name>A0A3D8QXW8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">beta-glucosidase</fullName>
            <ecNumber evidence="10">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_09378</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="10"/>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QXW8"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="UniPathway" id="UPA00696"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.300:FF:000006">
        <property type="entry name" value="Beta-glucosidase H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000495">
        <property type="entry name" value="Periplasmic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019800">
        <property type="entry name" value="Glyco_hydro_3_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF27">
        <property type="entry name" value="BETA-GLUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00775">
        <property type="entry name" value="GLYCOSYL_HYDROL_F3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PA14" evidence="11">
        <location>
            <begin position="395"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW66629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="832" mass="91158" checksum="AC610E835EFE71F6" modified="2019-01-16" version="1">MATFDVEEVLSKLTVREKIDLLAGIDNWHTAPIPEHGIPSIRVSDGPNGIRGTRFFNGSPAACFPCGTAMGATFDKTLLREAGVLMGKESKAKGASVILGPTINMHRAPLGGRGFESISEDPVLAGLGAAEIVKGIESTGVVATIKHFVCNDQEHERQAVDSIVTQRALREIYLLPFQLVVRDSRPSAFMTSYNKVNGKHVSESLSLIQTILRGEWGWEGLVMSDWFGTYSTVDAVNAGLDLEMPGPTKWRGALVRSAIAANNISLHTLDTRAREVLKFVNRCAQAGVEENAVERTNDTPETAKLLRKLAADSIVLMKNERHLLPLKKDKSTLIVGPNAKTATYCGGGSASLPAYYAITPFDGISSKLKQEPAYTVGCYGHKELPLLGAQLKNADGKPGIDMRFYNEPPTVKDRQVIDELSIVRTDMFLVDYSHPLLNEEFYATVEGTFTAEEDGNYEFGLIVWGKGNLYVDGKLVIDNSTKQTQGTTFFGSGTIEEKSTMPVKKGQSYHVLLEYSSSSTSTLKPEVLASRGGAIRLGGAMVLDPKAEIKKAVALAREFDQVIICAGLNSDWEGEGSDRETMSLPGYMDELISSIASENPNTIVVMQSGTPVEMLWLEKVPALIHAWFGGNETGNGIADVLFGDVNPSAKLPLTFPIRLQHNPAYLNYRSERGRVLYGEDVYIGYRWYEAIEQAVLFPFGHGLSYTSFSISSLSITTDKAQISTRVLVKNTGNIAGAEVVQYYIAQANPSIRRAVKELKGYSKVYLQPGEEKTVEVNLDKKYATSFWDEGRNAWISEKDTYCVIVGNTSATTDNNTLRANFDVEKTEWWTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QY90</accession>
    <name>A0A3D8QY90_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nonsense-mediated mRNA decay factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_09521</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Plays a role in nonsense-mediated mRNA decay.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QY90"/>
    <dbReference type="OrthoDB" id="2017974at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005697">
        <property type="term" value="C:telomerase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000202">
        <property type="entry name" value="Unplaced genomic scaffold supercont1.7, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018834">
        <property type="entry name" value="DNA/RNA-bd_Est1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045153">
        <property type="entry name" value="Est1/Ebs1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696">
        <property type="entry name" value="SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15696:SF0">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN EST1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10373">
        <property type="entry name" value="EST1_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA-binding" evidence="3">
        <location>
            <begin position="481"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="844"/>
            <end position="876"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="189"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU369098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW66772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="876" mass="98553" checksum="F0AC92DA2370F738" modified="2019-01-16" version="1">MPQQNVSDRWITHQRRNHKPPQIWCCVHCSDKKPFSTEPDLIAHATSSHANIIPTEQEHLRQWQQSYASQSLQQRRPSAKDESPRKPSMNDATRAQPEPPPNASGHVKRPLSHPTPARSLSGIQALNLGSPRNSEDAVMDEAATPDDGPRKRAALGDGISASGSSQQAPDSRENSQSPPPSRRNKNRPTSAPFNSSSAEMHLRKQTTSPLRPHVPSKKLWNPDQDSPVVKGSFDPSNVASTHAQKSRAPGLQSKTRKPHQPQGYNMSPRQSPVAQPSVILGSNKSIQTPLQQTPPISSTEQYDIMLELETRPISQEQLVAEVKGIYAGLVMVEAKCIEVDNKQATLAQQEGVHSKLNNEQWQALIALHRTLLHEHHDFFLASQHPSASPALRRLASKYAMPARMWRHGIHSFLELLRHRLPASLDHMLAFIYLAYSMMALLYETVPAFEDTWIECLGDLGRYRMAIEDDDIKDREVWTGVARHWYSKASDKAPTTGRLYHHLAILARPNALQQLFYYAKSLCVPVPFTSARESILTLFEPVLNTDSHAQFRLPPLDTAFVKAHGLLFTNREIERFDPTIDEFLMLLDNHINKVTRKFMEQGYQIAIANIVSMLGFASKDNIIIKAMFPSPVAGDITMEETLATSSPELLIFEKAERLHNSTLEIVLDRINDANILPFIHVTLVFLLRISQHPAAMKLIEEKFPWGPLARLLNALLASYSTLDRIESDKFPMPEKDDKRPFPEDYAIRGLLWAENYFPDDWFTNEKIDGEEKYHERASMTTYRKERILFLAYQVAKSGQWIQYHSQEGFTVSLDLFSGGSQCEPLAAGSRSLTFGSATTISGLDRSDTWTSHDLGPESEIEEDAQSSTMSPEAALMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYD0</accession>
    <name>A0A3D8QYD0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_09430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYD0"/>
    <dbReference type="OrthoDB" id="5411518at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39290">
        <property type="entry name" value="C3H1-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39290:SF6">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW66681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="343" mass="38836" checksum="CF4FD38294B577D3" modified="2019-01-16" version="1">MVSPDAVLENWKGMVDDDLEVTIRTAFDLPPVDDYVYAAESFQMTLAQVQESMATGMLTWNYWSPDHPPQRIPIPDSDVTAYTSIFSPTTDTAKSLKSFEANAKKSSPRALISSYLNSRRLVPSDLKIPKSKQHLNPYYDIWIWSCLKCHFIGPTNDYNYALPTNAKRTHPMLPILYHHFGCVCPSYEALSVISYACNRAKSDGVLDMASGNGFWTYMLRRHGVKCAAVDNMEAKWRYMWINDTIKANGVTYLKQNNGAQNQVLLMVYMVTRGDFTKQVLKAYKGSVIVIAGTQNANRFTSFGDITVEEYFAKDMPSWELAVRVALPSFAGKDEGLFVYERKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYY3</accession>
    <name>A0A3D8QYY3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1479-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09714</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYY3"/>
    <dbReference type="OrthoDB" id="8249012at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010856">
        <property type="entry name" value="Gig2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613:SF1">
        <property type="entry name" value="DUF1479 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G09280)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30613">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBIU-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07350">
        <property type="entry name" value="Gig2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW66965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="54084" checksum="CA4CCC5A8D9880DC" modified="2019-01-16" version="1">MAAVQKPMVEEPIFGFARDYTAPQTTTDRSARKQKVVNAGAWADTRGAKPKPLDARFADVKKRLVKPAHYAALQASWHRLLQAIEERVNVIEAAGPDFIPTVEFAEITPQGRFPEDFARQARERGCCVVKNVVSETQARDWKAAMVDYCARHPDIKGTPPAAPQIWKAYWTPAQAEARSHPAMLECQRAMSRLYHAGDEVNVDLDSQAMYADRFRVRPAGVENILPPHLDNGSIERWEDEAGYSSVFTAIWEGRWEEYDAWDMTHRADAVTDLYGGPGACSAFRSIQGWLSLSNNGPKKGTIQLLPDIKLSTAYLLLRPFFTDDGQLDMESTYFYGADPGMGQVLSTTWHPHLQLDRSIVSIPDIAPGSYVFWHCDMVHKVEEKHEGSEDSSVAYIPVVPLCKYNIGNLVEQRKAFLAGNPPPDMPPLPEEGVESDHADRGRPEHILTAEGRRMLGLEAFDALADGLTPGQKRMRELANRELGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R2E1</accession>
    <name>A0A3D8R2E1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clavaminate synthase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_08882</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R2E1"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="3">
        <location>
            <begin position="35"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="2">
        <location>
            <begin position="198"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW68225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="366" mass="41669" checksum="FD3856505B029A6A" modified="2019-01-16" version="1">MPSAAIEQVQPARPVKTPYSAIKESEQEFDWVDLSIIDLAEFDKPGGKQKLAAQLYDALKNIGFIYVINFGLTQEEVDEQYDFAQELFDTPLEEKMKYIADLDKGEYIGYKPFGLREVKPGVPENTEVYNIPRFSADVAPRPHPTAITNHWSKVEKFSKHIHQEIVMKLFALFAIVLELPEDHFTKFHQYNDNHSSYLRYMKYHARTPEQNEALDNIWLKGHSDFGSLTLLFRQPIVALQVRTPKGEWKYVKPYPESITVNVADTMQFLSNGFLKSSIHRVIAPPKDQAHLDRLGVLYFVRPGDDVVLTGAKSAVLKRENMLASSEAIVAKDWVKARTIANISAKEVEVEKQKLNNVGDGLTPVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R315</accession>
    <name>A0A3D8R315_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_08861</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R315"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF9">
        <property type="entry name" value="TAH-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="6">
        <location>
            <begin position="17"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="623"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="625"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW68204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="726" mass="80761" checksum="D259A72C06197137" modified="2019-01-16" version="1">MPRPPVPIEQRQRAPRACGVCKASKRRCDSRLPCSACVKRNNVYACSYSEPVGRRRNVRHASKAEPRIASQYPEHHVAIDPSSQVEPADQAFAPSPTMLSQSSGAATREPDQETATPVRVPVLTRSRMLFNAKRERVFLGDAASLSFLQFLREILAQHLGPCTFPENGRTRVTPEEDILSELPETSEDVEYKKALLESYFAASNGLLDLYTKDELAALMAETNNATDIPTETTAALYIAIAIGGQCRASGPLDLKYAKKYFFLGQKVAFQGMVEDPSITLTRSFLLMAFYMLGACRRNAAFMYLGIAAKSAYALGLHVTEHYASTTENERHLHSSTWKSLRILDITVSTFLGRLSATPTLMVEPETFDTYQNETSSNRRICQDAIYRAATIMDDIFQGLLSSKSIDTTTAEDYLQKLNAWSSGLPSDLRRFTRASPIQQSDQELLIGNIHVAGIYYWTVMLITRPFLICTMSCSSKTAADPFPYEKQSYAEIKKLSQVCVSAAIYMAQMCRSALEPGSLLDNMCVLKGWIYSAGLVLGFSLVTSADIRYDVEEAFSGARDVLQKLSQSSPRTEHYYDVLHRLNEAITKYRQKLANESRKKHTSLVTELLTIEVNAPVYAGQQRTETPDHRDGHSHVYASTNDREQDVRVNGNELPNHHNGPHSDMDKSVASDTNAWAAYDHNLPGLPMAFGAGDTDDTEAAWDSFAMQISQSFPIDNGFGQLFDNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7K4</accession>
    <name>A0A3D8R7K4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_08305</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW69908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7K4"/>
    <dbReference type="OrthoDB" id="4685598at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="268"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="552"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW69908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="585" mass="65676" checksum="E8AA443C5DA88861" modified="2019-01-16" version="1">MLPLSQAAAKRSHSPPSPALAASPVKRSRSVVSTPTPQTVDGDDGKASAKHASSGRPAADYPRKRVASHEEKADGADVLSKIFNRLERMEPCLERMEEHLRNSSTQPLTADSFPAEELHRALRQPSRQRDIESLPTPESYLSPTDRHVQRNPSLAPLAPWTGQPILTFKPAETHEISIPRLEGFRCLPPFNAAVYDDTEGYYQREFEQGATLYQPHGDEYLDLTPSVCYRLQRLFTKNVLIWVPIFDAEYCSAQFAEAVRCGFSSSSISVAITMFVLALGAISNEEEYTGNCAKEFAGISYFQKACKIVDENRGQMNSIIVVQCRILWSLYALFCMRSLQAWNAISEASRDVVVLCHFRSRMESDSQFGQMVRRAYWACYIIEYELKGPIRLSQGLRMFQETMPLPSSEHNEPGFFYFLSEIALWRLYESVFDNIGFSAGLTRYAPVVALELCSQLSEWYENLPGSLKFPRGTMPLLDPQKAFLRAQYYSIICVTKWSFIVRFVAQNPDFRGEQDILITQGRDCLESAVLLSKLSRSLLPDDDLTSYVPGAATRADTGRRGGCGNQERSGNDGDLGRKPHGGCWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7Q1</accession>
    <name>A0A3D8R7Q1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7Q1"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW70057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="106" mass="10992" checksum="DF52998AF1AAE375" modified="2019-01-16" version="1">MLKKLIADPCAAPGAQGGRREGPDGAEAAQGVKAPKPHHTRIGQWPWVSNDRSATTCSSHTLVSSARHYNGASCIEPPALSARLKGGEAEADYMLEIPAEGGDSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7R2</accession>
    <name>A0A3D8R7R2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha N-terminal protein methyltransferase 1</fullName>
            <ecNumber evidence="5">2.1.1.244</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">X-Pro-Lys N-terminal protein methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_08464</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54712"/>
            <dbReference type="Rhea" id="RHEA-COMP:13785"/>
            <dbReference type="Rhea" id="RHEA-COMP:13971"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138057"/>
            <dbReference type="ChEBI" id="CHEBI:138315"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine = N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54736"/>
            <dbReference type="Rhea" id="RHEA-COMP:13787"/>
            <dbReference type="Rhea" id="RHEA-COMP:13974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138059"/>
            <dbReference type="ChEBI" id="CHEBI:138318"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54724"/>
            <dbReference type="Rhea" id="RHEA-COMP:13789"/>
            <dbReference type="Rhea" id="RHEA-COMP:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138061"/>
            <dbReference type="ChEBI" id="CHEBI:138317"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. NTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.244" evidence="5"/>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7R2"/>
    <dbReference type="OrthoDB" id="1298661at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071885">
        <property type="term" value="F:N-terminal protein N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008576">
        <property type="entry name" value="MeTrfase_NTM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753">
        <property type="entry name" value="AD-003 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753:SF0">
        <property type="entry name" value="ALPHA N-TERMINAL PROTEIN METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05891">
        <property type="entry name" value="Methyltransf_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016958">
        <property type="entry name" value="DUF858_MeTrfase_lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="126"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR016958-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW70067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="180" mass="19484" checksum="A340408580158F99" modified="2019-01-16" version="1">MADAQINHQDAIKYWQGIDADVNGMLGGFPYISRVDLQGSKNFLAKLGIGGKSKKKLDRAVDCGAGIGRITEGLLVNVASTVDIVEPVAKFSDGLHGKAGVGEIFVTGLEDWSPSEGAKYDLIWNQWCLGHLTDVQLVGYLQKCRKALTGDGWIIVKENMSTSGEDIFDDVDSSVTRHDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7Z5</accession>
    <name>A0A3D8R7Z5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Map kinase kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_08566</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7Z5"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000165">
        <property type="term" value="P:MAPK cascade"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06621">
        <property type="entry name" value="PKc_Pek1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000294">
        <property type="entry name" value="Map kinase kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000263">
        <property type="entry name" value="MAP kinase skh1/pek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050915">
        <property type="entry name" value="MAP_kinase_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE DSOR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47448:SF5">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINAE MKK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="208"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="138"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW70169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="512" mass="55309" checksum="AC9BCFFCDCAB0C31" modified="2019-01-16" version="1">MSSPAPLLRPPIPGSRQNSGSRTPRLGLAIPPSPNAKAVNPPPKAPALSLQMPSRPSLPRLQLATPMGSNTTPYEQNSLQNGRPNPQPLTGQSASGGSESSAAHSRTGSFGPLDGRASGPTSAGSQYSAFSLASQYGLQSGAKGTPDPASAVGSMYSETSQGGAGMERDGSMNGLEAFDKLSLERGRTLDVEDLDDDGWRVASMEKRIEELGSLGEGAGGAVTRCMLKGGKTVFALKIITTNPDPDVKKQIVRELGFNKDCASQHICRYYGAFVEPSTATISIAMEFCEGGSLDSIYREVKKLGGRTGEKVLGKVAEGVLNGLTYLHGKKIIHRDIKPSNILLCRDGQVKLCDFGVSGEFGTKGDANTFIGTSYYMAPERITGQSYTITSDVWSTGVTLLEVAQHRFPFPADGTEMQPRAGLIDLLTYIVRQPIPKLKDEPEAGIKWSDNFKYFIECCLEKEPSRRASPWRMLEHPWMIEMRSKRVNMAHFLSTVWGWDDKKRPTSTITTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCE0</accession>
    <name>A0A3D8RCE0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_07761</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RCE0"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050956">
        <property type="entry name" value="2C_system_His_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43719:SF30">
        <property type="entry name" value="TWO-COMPONENT SYSTEM RESPONSE REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13188">
        <property type="entry name" value="PAS_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PAC" evidence="6">
        <location>
            <begin position="201"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="4">
        <location>
            <begin position="621"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="5">
        <location>
            <begin position="939"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="2">
        <location>
            <position position="998"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW71727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1078" mass="120193" checksum="6271FFD0E7B762DB" modified="2019-01-16" version="1">MVSSIMDHLSDLSQLSLNPPGVISTTPASHATKNGTQVTASEAISRPAQEVPVQDQRRGSLGPASNAPRQDLGPAVDKPLLATCDPEPVSLDWTLPSSRTDFSDHVKLCRSIDWSQTPLGPLSSWSPQLRQMANLVMIDPGPCILFWGPQSTVIYNEHYILMAGQNHPRLMGSDPFSIFPDAWDHFATIFKQCRETGQAIRQVDVNMFFNRHGYIEEAYFTFDMLPILGSEGSVVGFLEPVRETTKEKLAERRLSTLLCLGQLTADARSLKDYWKQVLHGLTLNGRDAPFAILYSVQNAVEKMNPSAGLMTQVCELEGTIGVPDNHPCAIQILDLMKSSDGFAPAFKIALKERTAMHLQRSDKAFPETLLNGIESRGFEEPCQEIVVLPVYPTASREILGFLVVGINTRRAYDDQYRQFIQLLERQLSSSVAGIVLLEEEMRRAEVNAQIAAADRDELLGRVEEMETRFKQMAEHAPVGMFNYEPDGSLIWANATWYEITGHPVTTSATLPFMELIDGGEAAVEETNRRWSALLDGQALVRYEIQLKKPWMKQLPGTDETFEGNTWVLASAYPEFDEVGGIKSIMGTITDISEQKWAEGVQDNRRKEAEELKRQQENFIDMVSHEMRNPLSAIIQSSDGIIGLLSSAKLLRTKEEIADIEDSVETILLCAQHQKRIIDDILTLSKLDSDLLSIIPTSIQPLHVVQRALKMFSGECIANNIDATLTVKNSFHKMNVDWVMLDPGRLLQVLVNLITNAIKITIPEQTRKINLSIGASLKRPMQNEHQINYLPTKLTRQDSDLEAPEGNEFFLKFAVSDTGAGLTEAESQKLFKRFSQALPRTHVQYSGSGLGLFISRELTEMQGGEIGFKSEPGKGSTFAFYIKATPTSPPRPSIKRSSSASKLSQTERDMAFLTRLAAGDVLSHSKLATSELNDSKDQLNILIVEDNLVNQKVLSKQLVNQNYIVHVANHGEEAIAFLHNTRFWAKGSKKDDVYMVLMDLEMPVMDGLTCIKKIRELQQNGEILGHVPVMAVTANARRQQIDSAISAGMDDVVCKPFRINELVLKMKAVKERISQMEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCS4</accession>
    <name>A0A3D8RCS4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_07883</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RCS4"/>
    <dbReference type="OrthoDB" id="3936150at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015606">
        <property type="term" value="F:spermidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000297">
        <property type="term" value="F:spermine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF38">
        <property type="entry name" value="POLYAMINE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="492"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="83"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW71849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="522" mass="56806" checksum="C581BE659C2B0BDC" modified="2019-01-16" version="1">MEAQPSSPTIFSSGDTASNRYSPQNGSSTITEHSPANNKDVENEPSAFKGSHDGKASELMISILEVDGVKNPHNWPLYMKVHASAASFAMTFAAGFGITGYTAGLTDVVSEFDVSMTKAIAGMSVYLFGNFFAPIYNPHLSERFGRSPIYLTNVFIWGLFILGAGYSKTYAALIVCRFFAGFFGGATLVLIEGTFADVWGQCVTSRYYSILTMASYIGAACGPLVCGFVIAAKTSWRWTQWVTLMIGLAAYLLGIGSPETYPRQIVRRRAARQGIPHGLEPALSGVTITQMAHVTIIAPLKMLVTDPIVIMIAFNLALNFAVLFQFFITVPVALNMLYSFKINQIGLAFLSAIVGSLAAVLITVISDIIMGPKKLPSDHDHDNNCMTHVEFRMWPAILGNLLMLGASFWVGWSASPMFHWAVPVVGTGFFVCGSALVLIAMVSYLFDAYSPRGTLAGLTAAACLRVAFAGWLPLVIVQIFDTITPKWGLGLWGFMFLLTVPIPVTILLFGFRLRERSAYRML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RD95</accession>
    <name>A0A3D8RD95_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Protein HIR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BP5796_08039</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 12">Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 12">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RD95"/>
    <dbReference type="OrthoDB" id="1741719at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000290">
        <property type="entry name" value="Protein HIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031120">
        <property type="entry name" value="HIR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011494">
        <property type="entry name" value="HIRA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019015">
        <property type="entry name" value="HIRA_B_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831">
        <property type="entry name" value="MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831:SF0">
        <property type="entry name" value="PROTEIN HIRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07569">
        <property type="entry name" value="Hira"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09453">
        <property type="entry name" value="HIRA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12" id="KW-0678">Repressor</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 12" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 11 12" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="27"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="15">
        <location>
            <begin position="29"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="67"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="128"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="170"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HIRA-like C-terminal" evidence="14">
        <location>
            <begin position="742"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="418"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="512"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="650"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="450"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="513"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="653"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU364014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDW72005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1049" mass="113382" checksum="C5C23210CA1CBB88" modified="2019-01-16" version="1">MRTGHSAGHDHAFHQAILAYSQRCHVSPDGKRLATAAGDGYVRIWSTDAIINAADTGYTEPKQLSHMSYHSGTIHTVRFSPNGRWLASGADDKVICIYHLDTNPPSHSASFGTNEQPPVENWKILKRLLGHDNDVQDLGWAYDNSIMVSVGLDSKIVVWSGHTFEKLKTISVHQSMVKGITFDPANKYFATASDDRTIRIFRFQSPAPTATPYDSMNNFVLEHTIAAPFTSSPLTTYFRRCSWSPEGNHIAAANAVNGPVSSVAIINRGQWDGDINLIGHEGPTEVCAFSPRLFSNQQETSNAPDRYNAHNLVTVIACAGQDKTLSIWNTSTSRPVVVVQDVAGKSISDLAWSPDGITLFASSLDGSIVSIRFAEGELGYVAPWDENDKALAKYGANRKGAGVVEDVAGFRLEEQSKASELRGAEGRMGALMGDSGGSPAPTINGNGTSTPMAGVTATTPTAASATTNGQAPADQEKEKPVPEVDENAEKLAAMKQRVTITKEGKKRVAPLLVSSSGTGQSSLPQSQLMASSSSNTQSDAPQTILDLSKPYDGLPRGGLAAMLLGNKRKAIVVEEEEEESQPNKRSNINGPIPIMINGVNGAEPAMAIPPQNGILPTPEFLRPAVINPIMSVSQVRLAVPKVRTHILRSLDRGTSANSTSAANGASGTEEPAKFSEDVILEAQNPEAHPAQIRDPSRISATKRGALLWQDFLPRAVILVTGNKNFWSAACEDGSIYAWTPAGRRLLNAMVVESQPVIIECRKWWLLCVTSAGMCHIWNLKTLASPHPPVSLAPILEIAMHTLGPAATTGPGVTSAHLNSNGNIIITLSNGDGYLYSPTMYVWQRLSEAWWAVGSQYWNSNDSSISSLQSTAVGPDSNRNGDVDSSNISAGIIPHLERHTTNEVLLKGRAYHLQRLIKTLLSKEGFEGFESGVSIAHLENRVAAAMQLGARDEFRIYLYMYAKRLGAEGLKNKVEELLRSILGGILKDNPDAPTTEKGEGWQSEDEQLCGWDRKELLKGVVLILGKFRDLQRLVVQYARVLGMVDEENGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIA3</accession>
    <name>A0A3D8RIA3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transmembrane protein UsgS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_07215</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIA3"/>
    <dbReference type="OrthoDB" id="10041630at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38421:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38421">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN USGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="103"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="379"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW73773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="406" mass="45624" checksum="665265902DB87145" modified="2019-01-16" version="1">MAHNQPRAPSSLLTKEGLRSKLEDVKSFDPNAILRGAQLTVVGAHRALQNPALFTSEHYRQAAYAIAAGIAIRLLIAIPIWGVKLLLWSLSFFIAKSATWDESIVSGLDFVMFQCLQIPFFLMSLMRYVTPTLDNMQVSVFNTFMDSLLWVDQTYYKKHEGEDANNLREGFYPNLRKYPTRDGSTHTTSTAEAVSMYLVRVGKRAGISLIVYALSYVPYVGRLVLPAASFYTFKQAVGIGPATVIFGTGIFLPRRYLVVILQSYFASRSLVRELLEPYFSRIRFSQEEKKRWFRDRQGLLFGFGFCFYIFQRIPLLGVLVYGIAEASTAYLITKITDPPPPPNQSEGFAASQQKWRNKHEIIQSSLSALDAHNLPSRNYSAAGQAQASTSAAPSEPPPPYTELRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIQ9</accession>
    <name>A0A3D8RIQ9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DUF726-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_07374</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIQ9"/>
    <dbReference type="OrthoDB" id="277931at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF3">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="609"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="186"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="449"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1002"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1069"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="961"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="66"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="198"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="215"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="250"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="454"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="502"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1002"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1090"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1157"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1183"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1211"/>
            <end position="1221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW73932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1221" mass="133123" checksum="C45DC2D8F3D42161" modified="2019-01-16" version="1">MPESVVEAVQETSASQTTDASLDTASTPANNGNVAAPNGTSSTTPDLDDFGLPLKKRKPSMAIAYEPEEVVDEEEKPELPSEPVNGHNDTPQSIGDPATFNDINLASDAEDSDDDFRDAQSTSNTEPQTPQEAIADKDIISNGDLKKEKAEEEHAISSNVDAAQVAVEPSEDTVVKVTEVDAAADAAVTATESEEPEQEKVVLHDVRDEPASKKTPPSSTAQKGHMRGQSSKGQAISEWSHQQLTTKDGQEEEADDDDGWQDMPAFAPYDMYDDDNKLIAREAHESDEEANAYSGLGGAGRGYTRVQLDEDAQSATSLDENTKYLFKDVHGTGAGELDDEEQRDALSQMQATKDLLTEGQRIAYVGMTRLVLSAMLKEAESIEATRGSKKEVVLAAEAMKMWTQKMMVRLYAHMDISTDEQIMVEQLAEHGVVPTDLTPTLMQNARVKNPMAESVSSPSNLASPRTESIASFSHRDSLSSLGSPEFARHPRDEEPAPVPPPYKEHDGEDLPEVRTPSQLPTTKNIDIDLRWTVLCDLFLTLIADSIYDARSRVLLEKVGQNMDVPWLEICRFEKRVTDALEMQQAAEKENWNEDEHKESRRKMALKKRYMMMGLATVGGSLVIGLSAGLLAPVIGAGLAAGFTTIGVAGTSGFLAGTAGAAIITSGAAASGGIIAVKAANRRTGAVKTFEYRPLHNNKRVNLIVTVSGWMTGKVDDVRLPYSTVDPIMGDIYSVLWEPEMLTSMGDTINILATEALTQGLQQVLGSTLLIGLMAALQLPVVLSKLAYLIDNPWSVSCDRATAAGLILADSLIDRNLGTRPITFVGYSLGSRVIFSCLKELARKGAYGLVQNVYLFGTPVVAKKDDYLKARSVVAGRFVNGYARNDWILGYLFRLTSGGISRVAGLAPVNGIAGLENIDVTEIVPGHMAYRAAMPKLLREVGWSVESDEFTEIEDPDPENHTSRQRELINEIEEARKEFEKKEKEGKGKFGFFGRKKKGAVERKEWETYEESKGEPSSNKRTEDGDGNNHGVLFDVDAMRAELATENEELEVKELRTTLPPMKLDLAAAASNPAVSPRLPLRETHSYGYETGSSLQVNNHSRSHSLSPRQSFSSQTKTSFDSKPLPTPRHEEEEELQMTFDTTYHPPTPSKALSFHKPSAPSSAAASTTNIPGDPLAGARPDLKTSQTLPATLPTINFNHNAWADEDDEDFGQEKEIEMTFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJ74</accession>
    <name>A0A3D8RJ74_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phytoene desaturase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phytoene desaturase (3,4-didehydrolycopene-forming)</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_07541</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Carotenoid biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the carotenoid/retinoid oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJ74"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016166">
        <property type="term" value="F:phytoene dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016117">
        <property type="term" value="P:carotenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000171">
        <property type="entry name" value="zeta-carotene-forming phytoene desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014105">
        <property type="entry name" value="Carotenoid/retinoid_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008150">
        <property type="entry name" value="Phytoene_DH_bac_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02734">
        <property type="entry name" value="crtI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43734:SF1">
        <property type="entry name" value="PHYTOENE DESATURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00982">
        <property type="entry name" value="PHYTOENE_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0125">Carotenoid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="561"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW74099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="580" mass="63927" checksum="0F2C5416C422C5D8" modified="2019-01-16" version="1">MADTRSPKTAIVVGAGVGGIASAARLAKAGFSVTIVEKNSFTGGRCSLIHHEGYRFDQGPSLLLLPKLFKETFHDLDTSLSLEGVELLKCDPNYNLWFGDGEKFELSTDASVMKREVEKWEGKDGFERYLKWLGEAHRHYELSVTEVLHKNFDSIFHLLRPSFIGKVFALHPFESIYSRASKYFWTDRLRRVFTFGSMYMGMSPYDAPGTYSLLQYTELAEGIWYPVGGFHAVAAALLRICERLGVTVRLNTPVESVLTSADGKTATGVVLTSGETLKADVIVINADLVYAYNNLFPSTTASSQSYARSLQKRDGSCSSISFYWALSQQVPELSTHNIFLADEYRESFDSIFDRQSIPREPSFYVNVPSRVDPTAAPAGKDSIVILVPVGHLLNSSTTASAKAGGIPAEQDWESIVAATRTTIQKTIETRTGCASLAPLIVHESLNTPHSWEETFNLDKGSILGLSHSFFNVLAFRPKTKHPQVRNCYFVGASTHPGTGVPIVLAGAKITTEQILSDFGMYIPWKDKPNVVQDTGVPQSKGLKDIDLIRKPVSRILGPEGLLIYFLIALLAVALVYGTQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJD7</accession>
    <name>A0A3D8RJD7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Sec20 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_07446</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SEC20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJD7"/>
    <dbReference type="OrthoDB" id="46868at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005606">
        <property type="entry name" value="Sec20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056173">
        <property type="entry name" value="Sec20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825">
        <property type="entry name" value="BNIP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825:SF0">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SEC20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03908">
        <property type="entry name" value="Sec20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="281"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Sec20 C-terminal" evidence="13">
        <location>
            <begin position="175"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="357"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="3"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="357"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="378"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW74004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="397" mass="44104" checksum="D30B3C5B5B34085A" modified="2019-01-16" version="1">MSFEVLSERLNALQDANAQLRDLIERLANMKFQPGSIPLGSGEDNAVVELRAQIQDTIKDQNEDFELLYEEALDITAGRPGSETASQKSALTSAVKRAMQELQSLQIDFRKAQLKAKRNLEAAQREERLLISQSYMQARNSNSLSPAPSLRPQAPERRKTLNKELTKEEKTVNAASDVTLALRRTHDMMASELSRSQFAHDTLRESTAALAQLGETYSALDTMLSTSRNLIGTLLRSQKSDTWYLETAFYVLLATIAWLVYRRFLYGPLWWFVFFPVRLFYRSLIGVLTGIGLVGGTAVSSSSPSAGSGSILHSSISVDMPEASMVDGGVPPLDKQAKNSPGTADDSLVEEIGKIIDERDLGVEEQGHSEPVPNPKKRMWEEETERVPVDGRKKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJI1</accession>
    <name>A0A3D8RJI1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_07558</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJI1"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000001">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017495932" description="Peptidyl-prolyl cis-trans isomerase" evidence="4">
        <location>
            <begin position="29"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="6">
        <location>
            <begin position="39"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW74116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="291" mass="31665" checksum="5AE88BB74359E83C" modified="2019-01-16" version="1">MLNLQRIAVSALLILTVTFLFFAKTAEAVKGPKITNKVYFDIEHDGKPMGRIVMGLYGKTVPKTVENFRVLATGEKPDVGGYEGSSFHRVIKNFMIQGGDFTKGDGTGGKSIYGNKFADENFKLKHSKKGLLSMANAGQDTNGSQFFITTSTPGHLDGRHVVFGEVLEGYDIVEAIENVPKGAGDKPVKPVKISKSGELPVPEEAQYGIAEFQPGMEEPIEVPIVPVPEPEAVTPVTPATQDPEVIEELDSEDGFSIMQKGLFFAVIVGCVAMYMKINGRKNKRYDDKSMA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RNI6</accession>
    <name>A0A3D8RNI6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_06483</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RNI6"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW75662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="123" mass="14625" checksum="9FA2EA55E07A49EF" modified="2019-01-16" version="1">MASLVVEIEFIQDRAEYEDEKPYILLAEEKEPGMGSRSLTNVEWLSRKVNVQDLRGREQMFELDKTGFQILLHPSMNLNFADIESINRYKRETEKLLMDTLKSSYVFCYDFRVFYNPNRIKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RP11</accession>
    <name>A0A3D8RP11_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_06507</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RP11"/>
    <dbReference type="OrthoDB" id="10335220at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="335"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="335"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW75686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="387" mass="43482" checksum="2DF3645F76998AAD" modified="2019-01-16" version="1">MTSLPPSPSPRPRKQRLTVSRPRDARNNTEINRSEPNLCFSPPKYPTPELSSQDSIPAPAVTDDDDLIDLDDKVQIKRGCAKTPHACRSPSLSDAEAEAWALDAEAGSHFASRHSAGLEQTPTSTWQLKSPRRFLFPTPTEANQQESENPCPVGACQEILQRYSLAEQHPGAAHSSCFIDVDHEPPSPSRSDLGEQLNAVQIDFRYCPNCIQSVGCGLVLLRDTMPTFRTMTGLLRDCWIRNAIEIRITSAHGYPIPYDGLPTFSLAKVFIALPGQKEIIWGREDEWQAALKEMKERGWRDCLVAVWVSDHGCAACQQMERDKRRAELEAMRKQWDEEKVLKEQKQQQQEDRDDASKRENSECDSGDGSEHENENDSQGVQGNEETE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RP81</accession>
    <name>A0A3D8RP81_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_06680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RP81"/>
    <dbReference type="OrthoDB" id="8300214at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW75859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="299" mass="32330" checksum="731D790C09B5D8F8" modified="2019-01-16" version="1">MDQAKIASQFLELRSPAEPEVSSPSLNSQMEHRIGLVSGPIWAIQKGKRVLEIGCGQGDCTVVLADAVTGSGEGWVDGVDPGSPDYGAPFTLSQAQAHILSGHYGGNIAFHNLAPEAYLAKYHGPVYDYTVLSHSIWYFENPSVIHTVVTSLEGKSHTLCIAEWSLRASSKEAEPHVLAALILASVESKRKEASSGNIRTVLSPKGIQSVVERDGKWKLVRDEVRQSTVGLLDAFWEVGYAIKTREKKLGGLRADGVSEKELAALVAMYDSLESAVGLLPEGVKSVRCMDVWVARFEAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPS9</accession>
    <name>A0A3D8RPS9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_06913</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPS9"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016620">
        <property type="term" value="F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07093">
        <property type="entry name" value="ALDH_F8_HMSADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016160">
        <property type="entry name" value="Ald_DH_CS_CYS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029510">
        <property type="entry name" value="Ald_DH_CS_GLU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43720:SF2">
        <property type="entry name" value="2-AMINOMUCONIC SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00070">
        <property type="entry name" value="ALDEHYDE_DEHYDR_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00687">
        <property type="entry name" value="ALDEHYDE_DEHYDR_GLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="6">
        <location>
            <begin position="52"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW76092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="510" mass="55756" checksum="9844ADA8AB9D4879" modified="2019-01-16" version="1">MSSRSDTDNVGTETITALWECNTLEKAQSLCSSLGNAAFPLQNFISNTYNTSTSTEYLDSHNPKTGKVFSRVPISSAEEVDRAVQNATEAFAGWSKTTRAVRSAYLGKITRLIEENRELFAVWESIDQGKTLERARIEVDRAISNFSYFSTYILHEANTVRMIDNVALTYEHRSPAGVFALISPWNMPLYLLTWKIAPCIAFGCTAVAKPSEVTSISAFLLTEVFRRASLPAGVVNMVFGNGATTGSALVKHDKIKGISFTGGTATGIQIRKDTAHQIYKHLSLELGGKNPTLIFEDVDMEKAIATAAMAAFENQGEICLCGSRIYVQKSIYATFVTQFTAHVAEKYQVGQRIGAVVSLPHYQKIRSYLSLAEEEKAVFELGSLPPSTPESGYWIAPTILTSVSPTSRIMTEEIFGPVVTIHPFEDEAEAISLANGNPNGLAAVLLTKDGSRIRRVGEKIEAGLVWVNCWLVRELGTGFGGMKNSGTGREGGAFSREVFTNLRTLHVPDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPU5</accession>
    <name>A0A3D8RPU5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Neutral protease 2</fullName>
            <ecNumber evidence="13">3.4.24.39</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Deuterolysin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_06846</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Secreted metalloproteinase that allows assimilation of proteinaceous substrates. Shows high activities on basic nuclear substrates such as histone and protamine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>Preferential cleavage of bonds with hydrophobic residues in P1'. Also 3-Asn-|-Gln-4 and 8-Gly-|-Ser-9 bonds in insulin B chain.</text>
            <dbReference type="EC" id="3.4.24.39"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12 13">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="12 13">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="13">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase M35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.39" evidence="13"/>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPU5"/>
    <dbReference type="OrthoDB" id="412874at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11008">
        <property type="entry name" value="M35_deuterolysin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050414">
        <property type="entry name" value="Fungal_M35_metalloproteases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001384">
        <property type="entry name" value="Peptidase_M35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37016:SF3">
        <property type="entry name" value="NEUTRAL PROTEASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02102">
        <property type="entry name" value="Peptidase_M35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00768">
        <property type="entry name" value="DEUTEROLYSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0165">Cleavage on pair of basic residues</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 13 14" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 13" id="KW-0732">Signal</keyword>
    <keyword evidence="8 12 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="10" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017496430" description="Neutral protease 2" evidence="13">
        <location>
            <begin position="18"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="306"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601384-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR601384-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW76025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="365" mass="37771" checksum="EB529DE7138D192A" modified="2019-01-16" version="1">MHGIAHKLALLATVANAARLDIAKRASPLEVAIAPVTEAPATFQVTVTNTGTEDLSLFPYGSILDTAPVQKLNVFAADSEVAFTGVFKSVLRTGLTAENFVTLAAGATYETTIDAAAVHDLSTTGSYTFVAEGALPYAAANSTELSGDALYFKSNIITMDVDGPAAAAVPNTITKRAAVQSDCSTSQRTVTLRALTNCASLARTASSAALSGSATKFSEYFKTTSSSTRSTVGARLSAVASECGSSSSGATTYYCTDVYGYCDSNVLAYTIPSLDVIVNCPLYYSALPALSSTCHAQDQATTTLHEMTHAPGVYSPGTDDNGYGYAAATALSSARAVLNADTYALYANVQRSTLDANRKYTGGSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RV52</accession>
    <name>A0A3D8RV52_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_05804</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="7">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW77952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RV52"/>
    <dbReference type="OrthoDB" id="10259622at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072670">
        <property type="term" value="P:mitochondrial tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01445">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017860">
        <property type="entry name" value="Peptidase_M22_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022450">
        <property type="entry name" value="TsaD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF6">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01016">
        <property type="entry name" value="GLYCOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="8">
        <location>
            <begin position="121"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW77952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="451" mass="49970" checksum="3C73D88E68E23647" modified="2019-01-16" version="1">MRPSCLLVRRAYASSKAICQQSRQLLTLAIETSCDDTSVALLEKHPNNSATLHFHEKITCDNREWEGVNPLSAHISHQKTLSALVKQALQKLPIQRPAIAHIGNSLLIPTQYGTETRRKPEFIAVTRGPGMRSNLNTGLDTAKGLAVAWQIPLLGVNHMQAHALTPRLVSALEIDETTGLNGDHNPAFPFLSLLVSGGHTMLVHSRDLCDHEILASSSDLAIGNLVDKAARDILPASTIKATSDVMYGRTLEEFAFPEEKPDYKYIPVFNNKGNFERLPTAYEHSLGVPFMLKPYEMEYSFSGIGAEVRRWMDSKPDMGKVERQVIAREAMRVAFEHLASRVLLALSKDDVKDVKSLVVSGGVASNQYLKHILRQVLDARGFEQMALVFPPPKLCTDNAAMIAWTGIEMYEAGWRTNLDALAINRWSIDPRAEDGGILGCGSWVREEKVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVJ8</accession>
    <name>A0A3D8RVJ8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thiaminase-2/PQQC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_05822</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW77970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVJ8"/>
    <dbReference type="OrthoDB" id="10028886at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008902">
        <property type="term" value="F:hydroxymethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008972">
        <property type="term" value="F:phosphomethylpyrimidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050334">
        <property type="term" value="F:thiaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009228">
        <property type="term" value="P:thiamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19367">
        <property type="entry name" value="TenA_C_ScTHI20-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.910.10:FF:000003">
        <property type="entry name" value="Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.910.10">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016084">
        <property type="entry name" value="Haem_Oase-like_multi-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013749">
        <property type="entry name" value="PM/HMP-P_kinase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004305">
        <property type="entry name" value="Thiaminase-2/PQQC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027574">
        <property type="entry name" value="Thiaminase_II"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04306">
        <property type="entry name" value="salvage_TenA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858:SF17">
        <property type="entry name" value="HYDROXYMETHYLPYRIMIDINE_PHOSPHOMETHYLPYRIMIDINE KINASE THI20-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20858">
        <property type="entry name" value="PHOSPHOMETHYLPYRIMIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08543">
        <property type="entry name" value="Phos_pyr_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03070">
        <property type="entry name" value="TENA_THI-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48613">
        <property type="entry name" value="Heme oxygenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine kinase/Phosphomethylpyrimidine kinase" evidence="2">
        <location>
            <begin position="19"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Thiaminase-2/PQQC" evidence="1">
        <location>
            <begin position="266"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW77970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="489" mass="54315" checksum="AD21BD0DD795E29D" modified="2019-01-16" version="1">MENHANVLLIGPLSHQATSGLEAEQRVLAAHQCHAVTATTAMLTRNDDESLDTIETPPEFLNKRIGISLKDAAVDVVKIEDSVGVTESTVEYLAAILKNNPKILSLLDCNEKSSAPLFAHLTVLCTTKADALDLLGLNSTTEGVNVDQFEIAKSLKSLGSKYVVIKPLFQATEEPLTVTVYGDDGLLTLKSDLSTSRLPAGLDSAFVASIAANIAKNLAVPKAVEAALRYIEACAKDQPVQLNYFHSIYKLPFTSGHFVDYLLARDDVQEAWKRHTEHEFLTRLANGTLPLEAFKYYLIQDYLFLIQFARANSLAAYKEKDLDKIVRSAEIVLHINREMALHLSYCKDFGLSKEDILNTEESQACTAYTRYVLDTGASEDWLALQVALSPCLIGYGVIARRLYDDPKTVREGNPYWKWIANYVADDYTEAVTLGIGEEIIFFEIAQIQLLDKHAQKQSPSRIEELVKIFIHATNMETGFWNMGYAKIGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVZ8</accession>
    <name>A0A3D8RVZ8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Exoribonuclease phosphorolytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_06020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVZ8"/>
    <dbReference type="OrthoDB" id="27298at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11372">
        <property type="entry name" value="RNase_PH_RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="6">
        <location>
            <begin position="12"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW78168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="250" mass="26528" checksum="3F151DA8D77869A4" modified="2019-01-16" version="1">MTLSSEPTAILSHLHRADGSATFSQNGYTVIGAVNGPIEVQRRDELAEEAAIEVIIRPAAGVGGTRERHLESIIQSTLRQIVLIQNFPRTLIQLTLQITGTPENETTGSKIVQAGSNLAILPALLQTSNLTLLSASIPLSTTISSVAVALILEDSSRSIIPHPTLLEIQRADSVHVLGFTSAGGLLIAESEGCFSLEDWDDIHIGAKQLCCGTSSEEGMSDAAEAGPGDMMAFIKSTMQEKVANDLSWKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWG1</accession>
    <name>A0A3D8RWG1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FYVE-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_06274</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWG1"/>
    <dbReference type="OrthoDB" id="10018316at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15760">
        <property type="entry name" value="FYVE_scVPS27p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000306">
        <property type="entry name" value="Znf_FYVE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017455">
        <property type="entry name" value="Znf_FYVE-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23164:SF30">
        <property type="entry name" value="EARLY ENDOSOME ANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01363">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00064">
        <property type="entry name" value="FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50178">
        <property type="entry name" value="ZF_FYVE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="FYVE-type" evidence="6">
        <location>
            <begin position="162"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="26"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW78422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="284" mass="31419" checksum="2CE8DB5E774D3ED7" modified="2019-01-16" version="1">MATDFAMPVQQFTTSPTQYNLYGTNGQQISPVNSATGTPNNISPTSPRTGAPPYMSQGVGQQLRTPRSPLYIPAVLRPTDAPRRTNRSSPLTPPHSKQNSFDDVASVKSLMRRSTADSGKSGIGAITEAEWSCEGLGKVTAPPTRDHWKADHESSICDEATCTRYFTYFTRRHHCRRCGNIFCDDHSSRVIPLDQDANYHPLGMRSRACSHCFNEFTAWQMTRFSRVNSDSSESDLETPSTPTVNCAVNKGLRGAMGNVFGQKHQGTPESLAQSVPRDWHWSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWL1</accession>
    <name>A0A3D8RWL1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_06321</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWL1"/>
    <dbReference type="OrthoDB" id="10254604at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020">
        <property type="entry name" value="FLAVIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020:SF50">
        <property type="entry name" value="UPF0659 PROTEIN YMR090W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="10"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW78469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="268" mass="28743" checksum="9BB8765D6565BA02" modified="2019-01-16" version="1">MSSPRVLLLGGHGKVSLFMTPKFTSRSWHVTSVIRNADQKPAILEAGKNGPGSIDVLIASLDDVKSQSDAQKILDQAKPDYVVWSAGAGGKGGAARTYAIDQHAAIHFIKSSIATPSIKKILLVSALSERRKPAPWWSDEDWAGIQKMNTQVLPDYYKAKLAADDVLTLLGEERMARDKSFSYICLRPGLLSDEQESGKVQLGRTGTTGSVARADVADVADRLLAAGARGWIDLLGGEKDVGAEVERVVKEGVTSIEGEDLEAMKASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWR9</accession>
    <name>A0A3D8RWR9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="12">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_06349</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="12"/>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWR9"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF134">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="59"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="317"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="325"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW78497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="345" mass="38863" checksum="61C35177B31DF1FF" modified="2019-01-16" version="1">MSSSGSDIMKSIPLPTIDRPFGIELWPIFDKAFTTIMGYHPQDFGFEPRVTPMSTLKESGIAIVVYYIIIFGGRELMKNRPAFQMNGLFKIHNFYLTAISFSLLVLFVEQLVPTVVNKGIFFAICDAKGGWTPPLVILYYLNYLTKYLELLDTVFLVLKKKPLTFLHCYHHGATALLCYTQLIGLTSVSWVPITLNLMVHVVMYWYYFQSARGIRIWWKEWITRLQIIQFVIDLGFVYFASYTYFTSTYWPWMPNAGKCAGEEFAAFSGMGIISSYLLLFISFYAATYKKGGKKTGRKAARSLTAAQVPDIATLTNGKVNGGASNGSAISTGTSPNRPVTRSRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWX3</accession>
    <name>A0A3D8RWX3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative alpha beta hydrolase fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_06163</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWX3"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017753344" evidence="1">
        <location>
            <begin position="21"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="90"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW78311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="353" mass="38975" checksum="CD81145D8FFB4F53" modified="2019-01-16" version="1">MMNFTQLFSLLLSLAALASSKTTNAPYSYSPYTYSPYTYSSDDTPAGGLSFQYPFPVHFYEFASQQKHLSMAYMDVPPANGTTFKGAIALLHGKNFCGATWNYTAHVLAADGFRVIIPDQIGFCKSSKILQYQFSLHQLATNTNGLLRSLSITNATIMGHSMGGMIASRYALTFPHQTHQLVLVDPLGLEDWQAIGVPYQIIETSFQTELATTFSSIKAYQQATYYSGNWSPSYDIWVQMLMDVYQGPEGRTFAYDMALTTDMIFTEPIVYQLPSLTMKSLLIVGDEDNTAIGKTWAPANIKPLLGHYEVLGKATAARVPNMTLIEFPTLGHAPQVEDPVGFHAALLGWLGQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S246</accession>
    <name>A0A3D8S246_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_05047</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S246"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002974">
        <property type="entry name" value="Cyt_P450_E_CYP52_ascomycetes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF18">
        <property type="entry name" value="CYTOCHROME P450 MONOOXYGENASE APDE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01239">
        <property type="entry name" value="EP450IICYP52"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW80349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="558" mass="62597" checksum="492EBCE15F1194C6" modified="2019-01-16" version="1">MVPVLGRITPKSLGAGKPVGRGCADPLGLYAPILTGGSQSVKKSTRSSEKLCISLSTVILLSIVAYISFSYVRSSIAYRAETAWGEQHGCMPIQVKLPYKWPLAIDIVRKGFRAHWDKQLLQLFQDLYRGLGPNIEQTLLGATGFVTIDPENIETMLSTRFEDYGFGPRRDAFFALLGEGIFNQDGPPWKHSRALLRRQFVRMQYQDLSAFQEHVDNLINALRSSDNVVDMQPLFFKYTLDLTTALIFGQSVHSLTNEGVDSFSNDFSEAADITAYRGRLGDLYWAYTPARFTKSCKAIKIYVDGYVQSALKTLEKGQDCPEGNVGQFVFIRELQDELKDPILVRDQLVNCLLAGRDTTACLMTWTFRLLVQYPEKLVRLRKEINDVLGDQQIVTRTHIRAMPYLDCVIKEVLRIYPPIPANLRFATKTTIMPRGGGPDGRSPVLIRKGWGITYAPYLMHRRVDLYGEDAEVFRPERWEDGKLKGIGWGWLPFNDGPRVCLGKDLALMEASLGILRIVQAFPNIKLPSGQVRGDPGTEKHALTLVLAPADGCKVQLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S299</accession>
    <name>A0A3D8S299_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pre-rRNA-processing protein ESF1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_05084</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S299"/>
    <dbReference type="OrthoDB" id="431825at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039754">
        <property type="entry name" value="Esf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056750">
        <property type="entry name" value="RRM_ESF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202:SF0">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25121">
        <property type="entry name" value="RRM_ESF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ESF1 RRM" evidence="7">
        <location>
            <begin position="173"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="6">
        <location>
            <begin position="638"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="216"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="397"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="418"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="477"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="516"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="541"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="560"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="589"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="604"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="617"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW80386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="718" mass="81484" checksum="C2CACCA511A51160" modified="2019-01-16" version="1">MPKPKQKTAKGSGATGASSTTPSDPRFSNFTTDPRFRLPSKKHTRTTIDKRFSRMLEDDDFSNTAKVDRYGRKLSSSGKKKALERLYVPAEDKEEDSDSDEEAEGDVEVEDDEVVAKELKRADSGYDAARGGGFSSSEDESDDDEEVEVEEEEATFPDMQTESAAVEMGEVSTRIAVVNLDWDNIKSTDLMAVFSSFAKPGRIHKISIYQSEFGRERMEREELEGPPKEIFARQHDEEEDSEDSEDDSEDEEEDEKIKKELLKEDEGKDFDGAALRQYQLERLRYYYAVVICSDNDTALNIYEATDGTEYLSSANFFDLRFIPDGTEFDEKPRDECQSVPDGYRPTEFVTDALQHSKVKLTWDTNPEDATRKDAINRAFSGSRAEIGENDLRAYLGSDSEEEDELEEQNEETDDEPSEEPKLTKKELARQKMRAALGLADEATTSTKTKKGGPVGDMEVTFTAGLTSTEKGSVFENEPIKDETTAEKYIRKEKERKARRREKARAQREGGETPAEAPEEGGGEEADEDLGFDDPFFATNEAVKEKAAKGNRKEDRRKKREAKEKEAEEKATQRAELELLMQDNSTETAAHLDHFDINEIARAEKQKKKRQRSKKLSKKGEEESKRGGLQENFEIDVGDERFGKLFENHEFAIDPSNPRFKSTEAMRKLLEEGRRKRGIEGDGEIVEKKEKKRKVENSEKTEGELSELVEMVKKRAKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2R1</accession>
    <name>A0A3D8S2R1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Polynucleotide 5'-hydroxyl-kinase GRC3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Polynucleotide 5'-hydroxyl-kinase grc3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="primary">CLP1</name>
        <name evidence="13" type="ORF">BP5796_05148</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Polynucleotide 5'-kinase involved in rRNA processing.</text>
    </comment>
    <comment type="function">
        <text evidence="9">Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of a pre-mRNA cleavage factor complex. Interacts directly with PCF11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the Clp1 family. Clp1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2R1"/>
    <dbReference type="OrthoDB" id="258143at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1030:FF:000001">
        <property type="entry name" value="Protein CLP1 homolog 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1030">
        <property type="entry name" value="Clp1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.330">
        <property type="entry name" value="Pre-mRNA cleavage complex subunit Clp1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03035">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028606">
        <property type="entry name" value="Clp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010655">
        <property type="entry name" value="Clp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038238">
        <property type="entry name" value="Clp1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032324">
        <property type="entry name" value="Clp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038239">
        <property type="entry name" value="Clp1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF6">
        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06807">
        <property type="entry name" value="Clp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16573">
        <property type="entry name" value="CLP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clp1 N-terminal" evidence="11">
        <location>
            <begin position="31"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 P-loop" evidence="12">
        <location>
            <begin position="134"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="Clp1 C-terminal" evidence="10">
        <location>
            <begin position="346"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="137"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW80450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="467" mass="51015" checksum="6FE98F54E33D47F9" modified="2019-01-16" version="1">MSIPGIPGLGQSVPVATSSAPVTVATTAIHELAPNSEWRFEVAIGQSIEVRVLSGTAEIFGTELALNHTYTFHGTKSSIYTWHGTRLEVTGSCEEYIAEETPMIAYVNTHFALEKLRQQAQQDGKEGPRVLVVGPSNSGKTSLMKLLTSYAIRMGRQPLVVNTDSREGLLSIPGCLTATAFASIVDVEQGWGSSPTSGPSPVPVKLPLCYYYGLASPEDNTKLFKPVLTRLALAATSRMAEDANVKESGMLIDTPGVISQGKGGYDIISHIVSEFSVNTILVLGSERLYSDMQRKFSTYRTSNSEAITLVRLDKSGGCVDRDDAYMQKSREAAIKEYFFGDVKRTLSPHTQQVDFDSLTIYKIRESNNMYAAFLPGGQEEAEPEAESLYEAVEPTSQMQHCLLAVMYASLNDSQEAIRDASVMGFVYVADVDDKKRRVRLLSPVNTRIADRPLILGSWPEPTMSLIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3Q8</accession>
    <name>A0A3D8S3Q8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">C6 zinc finger-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_05594</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3Q8"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF1">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="528"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="26"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW80896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="625" mass="70835" checksum="38239A35E5CFCD86" modified="2019-01-16" version="1">MSTDDLGAESSQATSNVRKRRRAAQACNICRVRKIRCDGREPCETCSTTGQACAYGAEPNTQSKSDLILEGILRVEKTLQEMNMRNSKVTSPGILSGYLRDENIISTPLSYGGPETRSRHIVSQSPITSGPNIHNAILSSFHTSTTESVLEWSCFDHVPSIRQSYVSIFGLEQSRPPIAERTTARIPFVSGSDLNNIINSFQHSVNFWYPTMSMQKMNHLRSRIMEGYEDNTTTTCLAFLMMALGCASQSVMKTFEAHDPEAANEQQSNKAMADMYFDGALKRIHVAQMEVSSTANQCFLFVALYFAFLQRPLQAWSYINATAAKCRLLLAYSPLESTAEDEECTRRIFWSCYILESDYLAELSALPQSGIAEIESSIPLPGDYSTHENRDTEEQSSLYFLACLSMRRLLNRVHNLLYAKETGAGLDDARFPYIVCELDHQLEEWRELLPSNFQFTVDTQSTVTQHGGFLRQRYLTCRSVIYRPYLTWLLTNFNESKESPPNVLEKCQVCLDACLLHMLNLRDFTHTVMVDTWICSLSMTCAMLILLAAIRVPALRDLIRSEATTVGDHLQQLMHRWAQVPGHFQSPSVAQSLQMIWDVHGFIQHEYEQDDVRKRRLSNNTVDTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3W5</accession>
    <name>A0A3D8S3W5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_05654</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3W5"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF5">
        <property type="entry name" value="GABA TRANSPORTER (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="271"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW80956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="470" mass="51870" checksum="B5A299C31FE4F4FC" modified="2019-01-16" version="1">MSSWEVMAMNMGATFYNGGPQTLAWGIIAVVIGALAQASSMAELAAIQPIAGAQYHWTHLLAPENHKRFITWMQGWVTWFAWVSALAGSTSSEANILLGLISVNYTDYVYHSWHLTLLIIAQLVVAGLINMYAFRTIPWIELFAGVMHVLLFIIFVVVLSVKTPAVSSSNFVFFEKSVFSGWENSFVTWNIGLLVPAWGFIGFDGVVHMSEEVRKAKQAVPRAMIWTILINGVMAYGIILCLLFTMGNASVLHSSFPIIPICINATGLKAGTAMVCGLLVITFCVVTASLASVSRITWAWARDGALPHYFAKIHPYHRVPIRSLWLPIIIVGILSVLNVGSNSATVFSAFTALSSLGLYSSYIIAISCMLHARLTGRIGDGPQYSIRYGEWQLPRGWGTPINVFALLWTMYLTVWLPFPTTIPVTGRNMNYAGPIYVFVVVAAVMYWYSHGRKRWPGLNATAIAMVEAER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S949</accession>
    <name>A0A3D8S949_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative N-methylhydantoinase A carboxylase beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_04370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW82879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S949"/>
    <dbReference type="OrthoDB" id="5404895at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1610.10:FF:000001">
        <property type="entry name" value="Hydantoinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.390.10">
        <property type="entry name" value="CV3147-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1610.10">
        <property type="entry name" value="CV3147-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048350">
        <property type="entry name" value="S-Me-THD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024071">
        <property type="entry name" value="S-Me-THD_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010318">
        <property type="entry name" value="S-Me-THD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027479">
        <property type="entry name" value="S-Me-THD_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF10">
        <property type="entry name" value="HYDANTOINASE_OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20906">
        <property type="entry name" value="S-Me-THD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06032">
        <property type="entry name" value="S-Me-THD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160991">
        <property type="entry name" value="CV3147-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="3">
        <location>
            <begin position="3"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="2">
        <location>
            <begin position="203"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="S-Me-THD N-terminal" evidence="4">
        <location>
            <begin position="613"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="S-Me-THD-like C-terminal" evidence="5">
        <location>
            <begin position="775"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="567"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF20906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW82879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1007" mass="106566" checksum="E999776D594AD5EC" modified="2019-01-16" version="1">MYRIGVDVGGTNTDAAILDVTAYDTPSRGVLASVKTSTTPNITTGVQDSIDQVIAKSGVQKDDVLSVTIGTTHFVNAVVEADARRLTKVAVVRLCGPFTKQIPPFSDFPADLKDIVNGGTYYVDGGLEIDCREIVPVDPVQVRETLAKIVSTGVTTICLVGVFSPLDHAGLHEERCKNIMLEANPAITIICSHNIGTIGLLERENATILNASILAVARKTFRSFSRAMLNLGLRCPLYITQNDGTLTDVATASETPVKTFASGPTNSMIGAAFLAGLDKSRAADLESEDELLAKQILVVDVGGTTTDVCALLPSGFPRQAPNFVEVGGVRTAFSMPEVCSLGLGGGSRVHQDEKTGDVTVGPKSVGHFLTSQALVFGGDVMTSTDIVVASKKQILGDPKLVSHILPEILTAARRRIKKMLKGVIDDMKVSSAPVTVLLVGGGSIIHMDDLENVAEVIRPPHHDGANAVGAAIAKVAGEIDVIEVLHESNEKAAIARLSQAAIDAAVQRGALRESVKIVRVEKLPLAYVTDRSTRIIITAVGSLAPPNLSTGLNPLLAAVDSMAELDTEDEVEAPKEAKSSAPSGSPVKPSLDIDIPTYRPAVRRHVWYLSEVDIEFIACGTGVLGTGGGGTSYYAMLHALDVLRTTGQGKMRVISLKALQDDNRVGFGSYYGAPSAMNEKISSGTEIQTAIDTLDRVLGNKGFDALLADEIGGGNGLAAFPVGSHYDRPVIDGDAMGRAYPTMEHSTLYIYGQPIVPCAIADGKGNVSVVMSAESNARVETMLRTTSIDLGLTTAVVACPLPGSAVKQLAIPNTVSQAWYLGRAIHMARKAKTSIMTAIFDVNPGRLLFSGKIIDLSRGIAGGYTIGKVLLSPLLAEEKDEGSVASRSLATTATTTDRSSHISIAFQNEYLYARRADAEGIEGEILCTVPDLISILDQDGEAVGSQDLKYGLKVHVIGMPAHPLWTSNQKALDVGGPKYFGLDMEWTSVGEYTIPRSVIDDFNSEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S9I0</accession>
    <name>A0A3D8S9I0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Thiol-specific monooxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_04507</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FMO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S9I0"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000138">
        <property type="entry name" value="Flavin-containing monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000960">
        <property type="entry name" value="Flavin_mOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050346">
        <property type="entry name" value="FMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23023">
        <property type="entry name" value="DIMETHYLANILINE MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00370">
        <property type="entry name" value="FMOXYGENASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW83016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="51306" checksum="1AD3145727C4D098" modified="2019-01-16" version="1">MGSIARGFAVKRIAIIGAGPSGLAAAKYLKAERAFSEIDVYEQQSEVGGVWNYTPNIAGKTTVPQTNPQVPLDEPIWPKGASVPLFSNPMYDHLNTNIPKDLMQFSDQPFLAESLLFPSREDVQDYLVRYSQDVRNLILFSTQVQNVRYEDCWKVFSKNLSTNEATLKEYDAVIVASGHYTVPVIPSVKGIEAFHAAYPFVVSHSKTYRNPTTYKDKKVIVVGSAASGLDIGNQISDVCQKPLLNSVRTLSPIKPDPRYKEELPPIVEFVVEDRAVKFADGRLEKGIDAVVYCTGYLYSYPFLDSLDPPIITSGQRVIGLYKHFISISHPTLAFTALQKKVIPFPLSEVQSSVLAKVWSNKLQLPQKQEMLDWENQLLREKGDTAEFHVLGTPGDGQYINDTHDWAMTADGPVTKEPPYWGKRLQDIRAIFADIRKKFIENGASAKTLEDLGLHFESDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S9Y0</accession>
    <name>A0A3D8S9Y0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_04432</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW82941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S9Y0"/>
    <dbReference type="OrthoDB" id="3491535at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0085020">
        <property type="term" value="P:protein K6-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF8">
        <property type="entry name" value="BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="132"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="165"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="198"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="231"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW82941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="260" mass="28626" checksum="67A754FED8E49961" modified="2019-01-16" version="1">MSEKHTVATNSRSLQGAKERKRQQNRIAQQTYRRNQKQRLQALEAAVGQSLDLTSPFMSSQGDNTTPTTQGWNFNEVDHTLPSPSFDQFLFPSPRTETIKHNASVDLSISTENHNSCLPSIIARPQSSSGCSPSSALHRAIERENIPMIRLLLERGADVMKKDANGLTSFHVAVKNGNEEVVKLLLDRGLDPNVKDSLSRTVLFYAVESENEHITKVLLDASVDVNSIDTHGNVALYLAVERGSMSLANLLLSYGADVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SA47</accession>
    <name>A0A3D8SA47_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">25S rRNA (uridine-N(3))-methyltransferase BMT5-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_04733</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SA47"/>
    <dbReference type="OrthoDB" id="273345at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070042">
        <property type="term" value="F:rRNA (uridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019446">
        <property type="entry name" value="BMT5-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF26">
        <property type="entry name" value="FERREDOXIN-FOLD ANTICODON-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10354">
        <property type="entry name" value="BMT5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="25S rRNA (uridine-N(3))-methyltransferase BMT5-like" evidence="2">
        <location>
            <begin position="61"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW83242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="288" mass="31637" checksum="C7FEBA988270DE5D" modified="2019-01-16" version="1">MGKNKRQKLQSSGGKKPKPALAKTQGGRVSKPAPNTPKPKSHIQASQAEPTIPFLFNDQILLIGEGDLSFARSLVENHDCRNVTATVLESGKDELEEKYPHVGENIEVLEAAGAVVKYAVDATKMLPWTDKKGRGGVGIMDRIFFNFPHVGGKSTDVNRQVRYNQELLVAFFKAALPSLSPKSGSSIIVTLFEGEPYTLWNIRDLARHSGLQVEKSFKFQAKAYPGYKHARTLGVVKSKKGETGGGWKGEERPARSYIFVRKGDKGAPLLGTNKEEEKDDEGEEEADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SA74</accession>
    <name>A0A3D8SA74_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Peroxisomal carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_04661</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SA74"/>
    <dbReference type="OrthoDB" id="446044at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015217">
        <property type="term" value="F:ADP transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052217">
        <property type="entry name" value="Mito/Peroxisomal_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939:SF1">
        <property type="entry name" value="MITOCHONDRIAL THIAMINE PYROPHOSPHATE CARRIER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45939">
        <property type="entry name" value="PEROXISOMAL MEMBRANE PROTEIN PMP34-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="10"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="119"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="212"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW83170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="338" mass="36369" checksum="297CB20A2C19E469" modified="2019-01-16" version="1">MVAASKEAAIPPWGLAVAGATGAVIANALVYPLDIVKTRLQVQVKRKPTDLASTDVDATHYTSTLDAISKIVAEDGASGLYAGINGALIGVASTNFAYFYWYSVVRTLYISSQKIVGPPSTLVELSLGAAAGAVAQVFTIPVAVVTTRQQTQGKGEKKGMVDTARDVINSEDGWTGLWRGLKASLVLVVNPAITYGAYQRLRENIFPGKANLRPWEAFLLGAMSKSLATIATQPLIVAKVGLQSKPPPSREGKPFKSFIEVMQFIVQNEGLLGLFKGIAPQISKGLLVQGLLMMTKERMELMFILLFRYFRKLKSEQLQKAAELAASKAKQALPLVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAK5</accession>
    <name>A0A3D8SAK5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Erythromycin esterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04635</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAK5"/>
    <dbReference type="OrthoDB" id="5204833at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="383"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW83144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="657" mass="70591" checksum="6CFDDB15F66583EA" modified="2019-01-16" version="1">MSPPRRRSSRLRGSSATPAKSLVHANRLDALAERDETPTSGPQSNLDDVVTSPIPPHTPATAGRIKPALEEMHPSKAHQSTTEQPDSGLRLGFTDIDTSGSNLPSGVKQKTPSKTGISSTFDFRFARPGPQLGPEAQRMMEELREDAARIKAKLAAEQEEAKRKKAENTSISSRKIAQPKGKAGRYSDVHMAEFKKMDSIAGHPSSFRALPRTPSRQNLKRTQSKANLDDREAESSKRDQPNRSGRLENTAPAKRARQHIADDASTARPVSRDTNSSVKLLPSTPTHQRSHSSFLSSITTPTQASLARAASLNKSSALIPTLSRSPSKQTLATPGRLRKTATVGSISSTPKSKSKVTLRSPGKLDRVKSALRYPGFSSKKEQASSSMARSTTGPDLDKGLPPLPSTPHTIQRSRNVKHVNFTPDTMNKHGATVQHSPSPVKSGIPRSISRTNLSAAAKVPNSESQGHTSNTMGANDASIDNLSGTSNAVEYPSLAGVRPLPKVPQQSTSYPAKSQPQIVPPCVSGEFTFRCDNTLSVGGSPKGFGSSAGQASIRQVRPSMPGSFPSGNKENKAPIPSVPHGMSNKKRRRAGSDDSDEEDFERSPKKQKSGAPEGDMLMAPRLMAEKMAPPSRIPSPEKKKGLSLSRLNMLARPRARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAS9</accession>
    <name>A0A3D8SAS9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RabGAP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_04897</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAS9"/>
    <dbReference type="OrthoDB" id="27140at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000038">
        <property type="entry name" value="TBC1 domain family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000031">
        <property type="entry name" value="TBC1 domain family member 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF337">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="55"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="351"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="531"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="630"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="531"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="632"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW83406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="714" mass="79237" checksum="48D0973698CB9B77" modified="2019-01-16" version="1">MANYNGSGSSSVEEGHQITRRRQPMHIGTPLSLLEGREHILRFIEHPDEIGSALDPLDDDKNSPWNTLRQDEEMRAEIFQDVERCMPEEPYFRQPETQRMMLDILFIFCKINQDVGYRQGMHELLAPILWAVEQDAIAPSNQKEKSTIISASEELLMKDVLNARYIEHDAFTLLSLVMRTAKSFYELGEPEKNTAHEAGPNRTAQGGTSPIVERSKCIHEVYLARVDPGLAKHLTDIEVLPQIFLIRWVRLLFGREFPFEELLAFWDVLFAEDPGLDLVDMVCVAMLLRIRWQLIESNYSFALMLLLKYPSPVYPNGPQTFVDDAVYLRENFNTAGGATLITKYSGKPPVVPALDSRPQTPSDQPLSPSKKLSRTRSPLQTPAKFLQQQGGVEALFQGAAKGVYQRGERLGINQAVRNAVGEVRKNMQELQVARANSMNRTASGDSRWSLDEGRSIHTSKSSAAAMSHRNRQLAQMLDDAMKGLREVSASTDGEKARYVQAMDLAIAKVDFVRVYLEDATMPLPEEVIQPASTGSITKTQNATKDEHPLTSAADSVTATLDLQAKQTTTVETLPTPIVTDGIEKDPAGQEVNDTESLIPKKTAVQALRPKAPVPTRSSIAQSSFSWMLEPDSAATSGTSPPKSPSPFLKSTKKPIAGTSREKKSFLFGDDGGDTKLRNSKLPSLLEPDEAFILGTMKGGKGKQVKREFTDQEPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SB20</accession>
    <name>A0A3D8SB20_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04469</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW82978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SB20"/>
    <dbReference type="OrthoDB" id="5406216at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031452">
        <property type="entry name" value="Kre1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17056">
        <property type="entry name" value="KRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017789093" evidence="1">
        <location>
            <begin position="25"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW82978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="118" mass="11713" checksum="CA47544A6055FD2E" modified="2019-01-16" version="1">MQFSSSSLATTLLLLSSALTPAYAQLAGRQVAAGGGAVAATTVATQQATTTYAASHVVVGTSTTVEYLMFTQTFAATALGTWAFGSVTSSGSIGLGTISGSVGNVKTKRALPTPDFAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SGF0</accession>
    <name>A0A3D8SGF0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">glucan endo-1,6-beta-glucosidase</fullName>
            <ecNumber evidence="13">3.2.1.75</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Beta-1,6-glucanase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Endo-1,6-beta-D-glucanase B</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Endo-1,6-beta-glucanase B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BP5796_03752</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Beta-glucanases participate in the metabolism of beta-glucan, the main structural component of the cell wall. Acts on lutean, pustulan and 1,6-oligo-beta-D-glucosides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>Random hydrolysis of (1-&gt;6)-linkages in (1-&gt;6)-beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.75"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.75" evidence="13"/>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SGF0"/>
    <dbReference type="OrthoDB" id="1887033at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046557">
        <property type="term" value="F:glucan endo-1,6-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004338">
        <property type="term" value="F:glucan exo-1,3-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000269">
        <property type="entry name" value="Probable glucan endo-1,6-beta-glucosidase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050386">
        <property type="entry name" value="Glycosyl_hydrolase_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31297:SF39">
        <property type="entry name" value="GLUCAN ENDO-1,6-BETA-GLUCOSIDASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 17" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 18" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017770330" description="glucan endo-1,6-beta-glucosidase" evidence="18">
        <location>
            <begin position="20"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="19">
        <location>
            <begin position="106"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00036633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00041472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00043257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RDW85427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="454" mass="50516" checksum="55BCAB5F52CF8C0F" modified="2019-01-16" version="1">MHSRIYALILLVLISFSSAWLPGTDKTLVAADGTDLFSSSSPASNSSKQASRRWLKTSEKIRGVNLGSLFVFEPWLASSVWESMGCGNTKSELDCVTALGQTKANSAFQAHWAAWITQNDITTMKSYGLNTIRIPVGFWMDESLVNTETENFPQGGFEYLAQVCQWASDAGLYIVIDLHGAPGAQVADNPDTGQYVQTSGFYTADQYDRAVSFMSWLTTQIHSNTSFRNVGMLEIVNEPLQYSSKTATMISSYYPDAYTAIRAAESTLAIPKKDLLHVEMMNSLWGAGNPHQDLKKTRFMAYDEHRYLKYITSIPVSQSSYLSASCNAKPNSDHETPTVVGEFSLSPPDNVSSTSDWDTSTTDNIAFYKNWFAAQATTFEKHTNGWIFWTWKSQLNDYRWSYSEAVTAGVIPTDLDDIYTYGSCDAYSVGVMSSSLSNRMWFVIILAIVLIVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHT5</accession>
    <name>A0A3D8SHT5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_04049</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHT5"/>
    <dbReference type="OrthoDB" id="69269at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058055">
        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509">
        <property type="entry name" value="PA-PL1 PHOSPHOLIPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF6">
        <property type="entry name" value="PHOSPHOLIPASE C1020.13C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01127">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDHD" evidence="2">
        <location>
            <begin position="843"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="158"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW85724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1070" mass="117320" checksum="6ACC4AD041253CD9" modified="2019-01-16" version="1">MPSSTHTYGPTCLLAQSVFKAGSRRGDDDIPDLKAQFFYTSALPIDDPLSAAPSPAGSDTTRHPPRPFSAYDNNTLEEAWLSLASEKDRKHHFKGKPPMWATKDDTERRASILKRLAAKSGKKSTQGDDIMSTIPQSPLQAPVLEGEAVPDMENLGKALESSSKTESVHKNKKTKDDGEGAVESAEETGKSGKEKGHEAPEKASNEPSCTDKDHGVHPQHCTCCGQNPDADGQACCKCAEQRTNTGDQQDGASDSKPTPSSKPTPNLNASKEHRALEKHQSHKGHKEHEKHHHHTQSKGHKEFERHALHDQALQSGELADAGPSRALPSGPAGITGSPFARVPSRRSSPLMQSALPDSDEPNGEADQNQAKIHVSGHVTELSEETVEVPGCRAHKNFKEKDDLEVPVGISRLHLVKLPSLQLKPIYWSPVHDQAAVTRGTWFYRDSMYPVEPAVANQLEIGYRELRPWSQTWKDELSSALEVGAAGEEKLAHRLWPKEADQEHSRKTDDQDAKRGPSESILSTDPYCAARCFNGEAAATGSLDDEKASDKTTIVKRYLNSQVIFKDGDNAFILKPSMVPSAYYSRKPVTKIMKGHTVGIHVVRGFNWKFWDKLHPSKKGATVAKAEENAPVASNAAATKDTACAACRSHEERPQVTDLVLVIHGIGQKLSERVESFHFTHAINAFRRSVNVELGSEAVQPVLRKGLGGVMVLPVNWRSNLSFEEGGPKKGHAENKESVDPEAFTLNDITPETIPAVRSLISDVMLDIPFYMSHHKPKMIEALITEANRVYTLWCKNNPEFHDAGRVHLIAHSLGSVMALDVLSKQPTYAPKTSPGKKINTKHFDFDTSNLFFVGSPAGFFLLLEKGELTPRRGRAKPGADFEDIHSGSVTGLPGTFGSLAVDNVYNVMHYNDPIAYRVNATVDPLYAASLKNAQVPSATTGFFESIGNAIKSITPGVTAPTELAVGQLTKPPPFQRLPSQLEMDVHDFTREEIAEKKFHLLNDNGQVDWFLSSGGGPLEIQYLNMLGAHSSYWGSPDFVRMLVTEVGREPGKRNTLPNLRAVKVGHRKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SI85</accession>
    <name>A0A3D8SI85_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_04341</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW86016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SI85"/>
    <dbReference type="OrthoDB" id="1658288at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047499">
        <property type="term" value="F:calcium-independent phospholipase A2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019369">
        <property type="term" value="P:arachidonate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046486">
        <property type="term" value="P:glycerolipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24185:SF1">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="5">
        <location>
            <begin position="27"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="4">
        <location>
            <begin position="31"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="4">
        <location>
            <begin position="85"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="4">
        <location>
            <begin position="281"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW86016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="450" mass="51809" checksum="7AA9816839D2B609" modified="2019-01-16" version="1">MEYQANTRSNINENSTSQAIKEIALGLTLDGGGIKGYTSLLILQRLMLFVSIEEVSEPRNEAPTPEELRSITPALPHEYFDYIVGTSTGGLIAIMLGRLHLTVEECIHEYDTFAHKIFARPRRGHVRSLLWLPRSKFDCRELKKFIQDVIKHHKYPNTANSDNSEVDRGAPWKMFSDPPLVGRPLCCSGTCDCFSKGTSESEATSHSCKTAVIATKKEYPSSRAWFIRSYIHENTLNLDIPPGTTSTKYEIWEVARATSAAPGYFKPLIIEGEEKEVQFMDGGLEYNNPSLLAFYEMEYMAKNTHATRNIELRGCLVSIGCGISAFDVFPEDKQWPATRYIKLLRAFRKIATDTEKAHKDVKAATDLHQFPYYRFNVDKGLEKVMLDDWGYKRREFVEDGEQKSERLRTFEYFRRVTLNYLEQPNVKEKMRDCAKLLVRYHRQRREVGYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SLM3</accession>
    <name>A0A3D8SLM3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_02911</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SLM3"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF26">
        <property type="entry name" value="GENERAL AMINO ACID PERMEASE AGP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="187"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="44"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW87217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="532" mass="58584" checksum="E49B3167B211B6A5" modified="2019-01-16" version="1">MESPEVKSAAVEEIRDESSEGKVFARIEGTVIDDGVRRALKSRHLLMIALGGVIGPGTFYATGFALRYSGPVGALIGYIIIGVDVYFVTQSLGEMATLFPSTGSFNEFAGRFVDPALSFALGWNYWFMWVTILGNEYNGAALILSYWTDKLPNYAWILICWGFFMCTSLLGVLVYGEMEFWLASFKFIIVIILYLVAILLDTGAIGGDYIGFRYWKDPGPFSNGINGFGKVLVLAAVMYSGTEAIAITGGESRNPKKDIPKALKQTFWRILIVYIGMVFFTGLIVPSNSKSLLSATSKSASSPFTVALEQAGWSRAGNLINTIIVITLLSSINSAIYIASRCIYAQAKVGRAPKFLAKTTSNGIPVNAIVMTNLCGLIALLNITQNAGNVFTYLLDISGAAAFIAWAFIGLTHVRMRAAMNAQNMPVSSLPYISWGFPYLPWILFVANIFLVFISGYTTLLTPFDLKGFIFSYLVIPLFFILFIGWKLWHKTKWVNPAEADLTSGRREWLQVADEEKVGRSLLRRTKNALIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SLZ6</accession>
    <name>A0A3D8SLZ6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03039</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SLZ6"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW87345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="226" mass="24351" checksum="256496E8FFBA3195" modified="2019-01-16" version="1">MNPTPTDQERRARRDRKNASWWQHKAENMDGQARKSSGYELCLLRAGPAIMGMWQRARSERAQSEAAADRVGLPAEAAPPRPDQHFSSSPKWASKGLPSPVPPAAAPHKATPCETGVFTSPTPNGALLTGGISIPSMTPRRHLTQDPATPVPPTNAFALIDSPAVLPCEIEPWAAHPEDEMGFSEHSGRRAHQVDFGLLLPEWPNCVGREAAAMDNSGGFGTGRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMW2</accession>
    <name>A0A3D8SMW2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Meiotic expression up-regulated protein 6 PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_03320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SMW2"/>
    <dbReference type="OrthoDB" id="5593352at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039712">
        <property type="entry name" value="Meu6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039483">
        <property type="entry name" value="Meu6_PH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42073">
        <property type="entry name" value="MEIOTIC EXPRESSION UP-REGULATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42073:SF1">
        <property type="entry name" value="MEIOTIC EXPRESSION UP-REGULATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15406">
        <property type="entry name" value="PH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Meiotic expression up-regulated protein 6 PH" evidence="2">
        <location>
            <begin position="92"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="240"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="306"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="394"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="418"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="537"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW87626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="537" mass="56529" checksum="6C765FF7C4ED6408" modified="2019-01-16" version="1">MSEIQKPVEEPVAAPAPATTETPAVEAPAETKVEAPVEAPVEPSTETPAAVESAAEETPAAATTADEEPKKEEVTPVEEGVLGYKGPGLLKSFIFQKKFFWFGSEPVESKSLSSYLRGEKPDAANHNAAWASHSGKGLLFFSKKPTEKASPAGIINLSEAKDLTEDGTVDFHFTIGAHKHTFQAGTLAERDNWVAVLKTKIAEATELASTIKDTDAYKSTLSSLSKPAAAVAAVATPKTTEAKKEEKAEAKEEKKEEKAEAKEEKKEEKKEEKKDRKDRSQSRKRQSIFGSIFPGKKEEPKEEAAATEATPVVTEATPAATEATPEVAPAAVESTPAPAAEPAAETPAAEPVTETKAEEKPVKAKRASIFGGLSFNNKKKEEAPVVPAKDEPAASEPVAESAPVIPAVESTEPLADSTATPAAAPATETPETPAAETEAPAAPANKRKSSLPFGFGAKKDKVVSSDDEAEKPKSPFAKLRATVKGKKSEKTQEKTPEVPEVPETEAKVETVAPTEAPVVSEPVPAAHTSTPQVSATA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SPG8</accession>
    <name>A0A3D8SPG8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_03382</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SPG8"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1300.10:FF:000003">
        <property type="entry name" value="Amidase signature enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF10">
        <property type="entry name" value="ACETAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="7">
        <location>
            <begin position="64"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="191"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="215"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="212"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW87688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="566" mass="62668" checksum="632E3BD1E73E0165" modified="2019-01-16" version="1">MVYLLDYFQHRKDCKFKQAERAQRIAGLSRYHGSFSSPEQEVLARSVEDLVRDVHKQVVQPIDILRVYGKAALKAHEKTNCVTEVMIGAAEGWITDGSINMKGPLAGIPISLKDSVVVGGFDTTVGYSCNVGNKNGVGLQDGTMVRLLKDAGAIPYVKTNLPVTLLSFESTNDVWGRCTNPHNNKYSPGGSTGGEAALLAAGGGRIGIGSDVAGSVRAPAHFCGIYSLRCSTGRWPKNGMCTSMPGQEGIPSVFSPMTRTLPDLTYFTKSMIGMQPWKYDHSVHPIPWRADTFQEFSEKKKFKVGVLRTDGVVDPSPACARAVDQVVAALKKEGHEVVDVQPPSPYEALCIASELLNSDGCKTFRSFFRTGEWEDTGAKQMARYMALPRIFKWVYYAWVKYVRRDDIWAGLLKNWHEKSAYEQWKLVAKREAFKAKFHDWWEQVAKIDFMITPPNATPAVPHDGMKDAVSSCGYTFLFNLLDYTCGIMPITHVDQGLDALPASFSMKPLNGVARGAYKHYDATAMHGLPVAVQIVGQRLEEEKVLAIMERIEASLGAEKYELMEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SX69</accession>
    <name>A0A3D8SX69_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02078</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW90913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SX69"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017572868" evidence="1">
        <location>
            <begin position="20"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW90913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="263" mass="29637" checksum="27ACB23E9DA1A710" modified="2019-01-16" version="1">MRTSIIVLSLLTWILSVNAEDLDKRQASNTTASSTSSFTPLPIPSQAPTVNSSIYDLTQHYCRLWRHASVYVNGSIYIDSGDTYTPQGNGTFNTTPPGQFDNGMNVNLLVIDLSKNFTENDTFPYRTIHKPPGVPPALEDSALWYSALTRKIYQLGGWFSRNGSPGTPGYVETQSIPEAAIWEFDIDTETWTQSKEFHDVDTGHKIDRPGAAAYCDAPDLNQSFIFEGFVQQMSDPDYVNYSLYHTFKYIEDTATLKRQERWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXW4</accession>
    <name>A0A3D8SXW4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">5-oxoprolinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_02337</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049517">
        <property type="entry name" value="ACX-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF2">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19278">
        <property type="entry name" value="Hydant_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="6">
        <location>
            <begin position="11"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="4">
        <location>
            <begin position="252"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Acetophenone carboxylase-like C-terminal" evidence="7">
        <location>
            <begin position="568"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="5">
        <location>
            <begin position="779"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1329"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="453"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1332"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1356"/>
            <end position="1365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF19278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW91172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1365" mass="148810" checksum="43F014F6C97C283D" modified="2019-01-16" version="1">MGSHTREKGIRIAIDRGGTFTDCVGNPGTGRMEDDVIIKLLSEDPSNYDDAPLEGIRRLMSKFLQKDIPRGEPLDTSKIESIRMGTTVATNALLERKGEKIAMVVTKGFKDCLEIGNQSRPKIFDLAIRKPDVLYEKVVEIDERVTLEDYAEDPERINTKTAPRGSSKESDDLVRGLSSEAVRILQRPNENTIRSQLQKILDEGIKSIAVCLMHGYTFPDHEALVGRIARDMGFSHISLSHELMPMIKLVPRATSACADAYLTPAIKKYIAGFQKGFEGGLGTESVRKEHGSKGARCEFMQSDGGLVDVDKFSGLKAILSGPAGGVVGYALTSYDPETKTPVIGFDMGGTSTDVSRYGSGRYEHVFETTTAGVTIQSPQLDINTVAAGGGSRLFFRNGLFVVGPESAGAHPGPACYRKGGPATVTDANLFLGRLLPDFFPKIFGKNEDEGLDLEASKKLLQELTEQINKEQGKNMTADEVAYGFLTVANETMTRPIRSLTEAKGHDTSKHRLATFGGAGGQHAVAIAERLGIRQILVHRYSSVLSAYGMALADVVDERQEPDSKVWADKGEVRESLQSKIAELKGKSRKALREQGFDDASIVFEEYLNMRYRGTESALMVIKPEKEDAKKDFNGDEWAFGQVFVKQHQQEFGFTLPDRDIIVDDVRVRGIGKSFEGLERTVDQQLKAISAKKLTSGSKEYGRTSVYFEGGRVETPIYKIEDLAVGDQIKGPAILADGTQTIVVTPTATALIINTHVVINIGESAGKEMPSPEQPESDVNPIMLSIFAHRFMAIAEQMGRALQKTSVSTNVKERLDYSCALFDHTGGLVANAPHLPVHLGSMSTCVKRQAEIWRGKLVKGDVIVSNHPEYGGTHLPDITVITPAFNATGDRILFYVASRAHHADIGGILPGSMPPHSRELFQEGAAIKSEKLVSAGRFNEDRITELLLKEPAKYHGCSGTRCLADNISDLKAQISSNMKGINLISALIEEYGEKTVDFYMVSIQRNAELSVRNLLKEVSKRFEGHDLSAVDYMDDGSPIKLKVTIDAEKGEATFDFSGTGPEVYGNTNAPQAVTYSAIIYCLRSLISEDIPLNQGCLKPIKVLIPPKSFLSPSDKAAVVGGNVLTSQRVTDVILKAFQACAASQGDCNNLTFGFGGNTEGEESVKGFGYYETIAGGSGAGRDWDGTSGVHTHMTNTRITDAEVFERRYPVLLREFSLRPGSGGAGKHRGGDGVVRDIEFRIPVQVSILSERRVYRPYGLEGGEDAQCGLNIWVRNVEVSNPERSDKLLNGSTDELDEAVFEERRINLGGKNTAAMKAGERIIICTPGGGGWGKAEERSGIKEPFTDPKHSWRGGSHANREEMALQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXX0</accession>
    <name>A0A3D8SXX0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Chromatin remodeling factor mit1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_02289</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Component of the NuA4 histone acetyltransferase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17919">
        <property type="entry name" value="DEXHc_Snf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056616">
        <property type="entry name" value="Chromo_MIT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055565">
        <property type="entry name" value="DUF7141"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041684">
        <property type="entry name" value="Znf-PHD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF17">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23615">
        <property type="entry name" value="Chromo_MIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23614">
        <property type="entry name" value="DUF7141"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15446">
        <property type="entry name" value="zf-PHD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="760"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="1064"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="134"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1348"/>
            <end position="1583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="20"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="270"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="1374"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1399"/>
            <end position="1413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1450"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1496"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1541"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1564"/>
            <end position="1583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW91124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1583" mass="178484" checksum="B87B035949E1BD4C" modified="2019-01-16" version="1">MTSDEDSEDELASAGIAERATSSGTNSSAAILCVQRSRHNRLDEQETKDRQQSREKSLAIVLPGPSKPWEYQRYDHSTTVDEIVGELKGSQGQRSYRIQYEDGSTEIVSPDHLSRMRNGDFALRRFQSGTNQYREALESDDQLSMASLRRKRSRTTRNHSDQTETNHDASSSDEGDSKRQRTTNHGMRRSRRAASRSTRSRNIYHEDKEDTSEDELPTRRSTRHSSKVPLSKTRLTRSVSVKPAIEHRNDESAGEVQETDDSEVEFEPRPRHRRRRKRPARKTARPSKFTLSADENDDDDDSSDDEPSIPTRKSGRTNQARKSMREQALDEELYAEEQPVVSTASKVVSVREIFQPLLENSPFRALHSKFCDVCAGQGTHSNKGTSPLIYCQGCSISIHKVCLGYRSGREHVVTKVGEDNFVMQCRRCIGIAIKKDSSAPRLDICQTCKEPGLGCAAFSAKKTSKQEEKLREENDGKDPITQVSLHLLDNAGNLLFRCRACQRAYHFHHLPALGRKSKAVESQAQIRERRLSEYSPSFHCMECRQQQAKIHVMVAWRPVDQESYEEGYTADMFREDEKEYLIKWEEQSYDKSTWMPGAWVWGVTAATMRNAFLRRDDGANLLPKWTKEDAIPEDYVTIEIIFDVEYQSDFESKSEKADKAKIGKVERILVKYKGLGYEDTVWQEPPDPEEKDLWTPFVSAYNEYVAGRYFKQRLGSEMRRDIEAFRDSDFEDAVDINRPPSALEGGELMPYQKSGLNWLLENYHKEKNIILADEMGLGKTIQIISMIASLVKDSPQCWPFLVVTPNSTCPNWRRELKKWAPSIRVVAYYGGRVARDMAMKYELYPGGCKDMRAHVVVTSYEAPVDDKAFFRKIKWAGMIIDEGQRLKNDANQLYTALTSLRVPFRVLLTGTPLQNNLRELFNLLQFLDPSQNAKDLEEEYEDLTNDKIKEVQTLIEPFFLRRTKQQVLKFLPPMGQVIVPVSMSVLQKKLCKSIMARNPALIKSIFGQTNKALRPQEKGNLNNILMQLRKVLCHPFMFSSAIEEEATPEVMQRQLIEASSKLQLLEIMLPKLKDRGHRVLIFSQFLNQLDIIEDFLNSLDLPFRRLDGTISALEKQKRIDAFNHPDSDLFAFLLSTRAGGVGINLATADTVIIMDPDYNPHQDIQALSRAHRIGQKKKVLVFQLMTKDSAEEKITQIGRKKMSLDHALIETMGAETEVPIDLESILKHGAEALFNDDDSADIRYDSASVDRLLDRATIENTTTDDDKTAESAFSHARVWTQKGELEDIGDSDVELSAPDASVWEKILKQREADAAAEAAKNMVTLGRGKRIRQTVDYQKTELDDALATSPVKMHGRRKKNGDVESDTEFAAAGESEEDEEDDPEHVDVNELQSGRPRHASNSSGKGTRKNPSSGKAKIVKPAPPKTATRIRTATLEAKLSTKNTTRKGTSKSTAPAKPPAARKSANSAPVQGGIGKTKQKEKHIPASQAKGRKALTKSNKTPGSKKSGPSTIKTNASEHTETVNKVALEQSCSKLERMRTSPATEGVQESSSTSLVPDKVDSRPLSSNVPAKHSSSCEETAIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SY13</accession>
    <name>A0A3D8SY13_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_02368</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SY13"/>
    <dbReference type="OrthoDB" id="8300194at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05120">
        <property type="entry name" value="APH_ChoK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002575">
        <property type="entry name" value="Aminoglycoside_PTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF54">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01636">
        <property type="entry name" value="APH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoglycoside phosphotransferase" evidence="2">
        <location>
            <begin position="178"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW91203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="399" mass="45199" checksum="0FD736787A61EB4D" modified="2019-01-16" version="1">MADASCSQNTNDKNDGDISKGGSAKAKLNQAVLERLQAAVKANPEIDLPSKFPLIHKRAVYEQELMKPTSFKLDNLKFTGLPKPTGPPNFCADLVARARNAEIVYALSDEARKFLSSYIKAEFQGSELIDSSLVSSLSQMILSCERLWELPTRGVVLKCNTNLIAKIIRGNSNYTEYTSIQYLAEHAPEIPAPKPHGLVKFHNVRILFMTHFPSMTLESAWPKLIHEDKISIQKQLNDIFIKLRSLVGDSEFLGGVNSEGVQDRHLEHNMNSKTISTVAQFENFQFSLMPPYDDLSWVKFLRSLLPPAPSTTVFTHGDVRPANIMVDIDETGKYFVTGIIDWETSGFYPEYFESVTMLYLFNINKEEDWWQYLPPCITPARHLERWLVGRLWDQAVHGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SY50</accession>
    <name>A0A3D8SY50_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_02427</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SY50"/>
    <dbReference type="OrthoDB" id="10330458at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW91262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="151" mass="17114" checksum="1E89239888EEFD97" modified="2019-01-16" version="1">MCEKVRVMHRCGHACFQNPPAVCYPDPPLGAPISLHICGKPIMLHFVGSRRLCINCRKEKRADMRSQLKKPSDPDYSVRATMQWMKDWDSLEMAFQRQRARTESAAWAVINTAIAAAQKEGAVGLFDEEVFQQIEKEQFGNLQNATAGAWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SY85</accession>
    <name>A0A3D8SY85_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative Fe-S cluster assembly protein dre2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_02384</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.</text>
    </comment>
    <comment type="domain">
        <text evidence="10">The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the anamorsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SY85"/>
    <dbReference type="OrthoDB" id="311633at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11000:FF:000002">
        <property type="entry name" value="Fe-S cluster assembly protein DRE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11000">
        <property type="entry name" value="Fe-S cluster assembly protein Dre2, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03115">
        <property type="entry name" value="Anamorsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007785">
        <property type="entry name" value="Anamorsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046408">
        <property type="entry name" value="CIAPIN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031838">
        <property type="entry name" value="Dre2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273:SF14">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05093">
        <property type="entry name" value="CIAPIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16803">
        <property type="entry name" value="DRE2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="3 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 10" id="KW-0408">Iron</keyword>
    <keyword evidence="8 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe-S cluster assembly protein Dre2 N-terminal" evidence="12">
        <location>
            <begin position="130"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Anamorsin C-terminal" evidence="11">
        <location>
            <begin position="344"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site A" evidence="10">
        <location>
            <begin position="348"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site B" evidence="10">
        <location>
            <begin position="409"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 1" evidence="10">
        <location>
            <begin position="409"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 2" evidence="10">
        <location>
            <begin position="420"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="348"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="362"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="412"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="420"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="423"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW91219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="446" mass="47839" checksum="AEEF02EA89053C81" modified="2019-01-16" version="1">MLVCPLPLCLCGHSFFGEKFTTLTNAQWQASPLVSNYYYSYASSPPLARHPRSHHSCLALPSRIPLALSRIRRIKVPTTCDSGLLSILLAGAASVATLYPAMAPSVMMIDNDSDFNPVFPPAKSAFPPTRTLLLAPPSIASHEDNLRNVLAAYDRAATDLQMLDRLSAGLVTLPDATYDLILVLTDADGTRRESSQLLTRDVFGRIVRALKFGGKLQAQDGTFGQTVGSDELREAILAGLVTQGDGMVKPDSAASQAVPLRFGRKKDTTAVSNAGPPVPTATVPVNGKRKSVDMTDNQPSGVGFVDFSDDFGEPIITGEDDDDDELIDEDTLLTEEDLRRPVNIPPECAPRVGKRRRACKDCTCGLAEKIAAEDAAKRADADAQLQTLKLGADDLAEVDFTVQGKVGSCGNCSLGDAFRCDGCPYIGMPAFEPGQEVRLLNNEVQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SY98</accession>
    <name>A0A3D8SY98_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Phosphotyrosine protein phosphatase I</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_02460</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the low molecular weight phosphotyrosine protein phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SY98"/>
    <dbReference type="OrthoDB" id="3388at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004726">
        <property type="term" value="F:non-membrane spanning protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16343">
        <property type="entry name" value="LMWPTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050438">
        <property type="entry name" value="LMW_PTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023485">
        <property type="entry name" value="Ptyr_pPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036196">
        <property type="entry name" value="Ptyr_pPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002115">
        <property type="entry name" value="Tyr_Pase_low_mol_wt_mml"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017867">
        <property type="entry name" value="Tyr_phospatase_low_mol_wt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717:SF7">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PHOSPHOTYROSINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11717">
        <property type="entry name" value="LOW MOLECULAR WEIGHT PROTEIN TYROSINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01451">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00719">
        <property type="entry name" value="LMWPTPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00720">
        <property type="entry name" value="MAMMALPTPASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00226">
        <property type="entry name" value="LMWPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52788">
        <property type="entry name" value="Phosphotyrosine protein phosphatases I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphotyrosine protein phosphatase I" evidence="7">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR617867-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW91295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="143" mass="16185" checksum="BD2D3FADB58797C3" modified="2019-01-16" version="1">MAEGIFRSLTSKPPYQAKIGLVDSCGTGAYHQGADPDDRTMATLVEKGITDYEHSARKVKSSDFDTFDYIFAMDRDNLRDLQRLQQRIGGKAKVMLFGEFSGRKPEEIDDPYYGGRNGFTVAYEQAMRFSKNFLKQTFPDTEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYI9</accession>
    <name>A0A3D8SYI9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative RAS-2 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_02519</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Ras family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYI9"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000654">
        <property type="entry name" value="Small g-protein ras2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="192"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="204"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="221"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW91354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="233" mass="25802" checksum="612E6657275B0268" modified="2019-01-16" version="1">MAGKMVLYKLVVLGDGGVGKTALTIQLTLQHFVETYDPTIEDSYRKQVVIDGQSCMLEVLDTAGQEEYTALRDQWIRDGEGFVLVYSISSRSSFSRIQRFHNQIQRVKESSASSPSYPGSPISSVSPSAPVPIMLVGNKSDRVTEREVSTQEGHALARELGCEFVEASAKNCINVEKAFYDVVRLLRRQRLQSVRQSPTSGKGQRMGGPGDGGPQRDSNRHYRSKSSRKCVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYQ8</accession>
    <name>A0A3D8SYQ8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA replication checkpoint mediator MRC1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_02466</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2130597at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024146">
        <property type="entry name" value="Claspin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018564">
        <property type="entry name" value="Repl_chkpnt_MRC1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14396">
        <property type="entry name" value="CLASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14396:SF10">
        <property type="entry name" value="CLASPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09444">
        <property type="entry name" value="MRC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication checkpoint mediator MRC1" evidence="5">
        <location>
            <begin position="1004"/>
            <end position="1142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="45"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="329"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="383"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="586"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="995"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1090"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1142"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1327"/>
            <end position="1373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="167"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="204"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="256"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="285"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="586"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="643"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="682"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="996"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1148"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1167"/>
            <end position="1183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1248"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1259"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1327"/>
            <end position="1351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="1352"/>
            <end position="1367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW91301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1415" mass="154990" checksum="98200162BBC28101" modified="2019-01-16" version="1">MASTRESTPAGDSGPPSPSQLTPNSKVKAMLAALDESDDDAISGKAAAKLSAATRKDTSSKPADSRRSSPRAERMEDSAHSTGQVDSDSNEDDEDIVRPKGRLAAQMLAADESSEEEINTAVTARDRVRQLLARKSKSPEPAAKASTDDSDEEDAPVQPRKRKVQRARSSTPISVLRQQSASPGLFVSPNSQRSASPPANESNSDSDDLPDEPLQDSRFLALVAKKRQERMEKDAELKRQKAKKAAENQKLAATMMEDEEMDDSDDNVERRLTQTQRPTRKAGKKALEEMHRETQRLSRSMQLAHQAKTKKKITKASLFAKFNYKPAGFSEADAESSAPTSSSPVHSDVEMRDTPPTSPASHANDVEKSTISLEAQSVETALHMSDHDEPQPLKEGLTVPSSPPAAIGEGYSVVMEAPDMITPSKADKGKGKAIESIPASAFQDKKPLFKQRRFRVQPPKVPNWNGLLSDSDSDIEIVNSKTPRKQRMDAIFDRVPEKKSSEASSLHALRMLAHLTSPGKQNIGKNKKPSMTTVELQMSLQQRARQQAAREREERLQALREKGVIVQTAEERQKELAEVEDLIARARREGEEIMRREKEAAKRARKARGEADPLDGSTDDEEWKEDEQKDPETLSASGSGSGNDEDLSGEEASDEEDLEEDDEVASVAEGDDTTVLNPLFDVEAESSEEEATAPSNHDEAEDEDEDLPVRTVTRPARKSNVISDDEDDVEAMVQSPNASVMNTPTHAALPVQPRTASPAAPHSVLRSATKTFIPGLTVAGPAGLGLTQIFAGTMDESQMDESPTFNRAEAQQNAKNSMAFLRQLPPPTLPPFEATLVQASQDMVMDSQAHVTESQTMETQAETQRISLDFSQSQIHGFDSLVHDPFATQISDFTETQDIGFQHTTPIKTRFMELPPSTVDTVLLESKTMPDIVAESPVAKKKGKLRRRVATAAFSDDDDDAAATEHVESMVADEDDFEISENVFDIMRKASKKKPAVADDFDRKKSKAKEMVNEQAEESEDEYAGLGGNSDDESGGEEDEYVKEMIDDAIGKDGDASKLAAFYADRERANDEKAVEKLYNDITKGMLRRKRGADYDLSDSDDGGEAKRRMKRREFAKMRKALLADERIGKIAENPKKQAFLRAIEDRGSEDEMDFLDDFAEPDETIESQSQSQSQAEGSEQIIPDSQTDTSMGPPKRKNSDDPYTESRPPPNLRRTQPNKKPANLSEIRESLSSLIEEPNSMIVAEDSGSDSELEIEGEPDKDSFKGKEKENRDPFALRRKDVPVIDRISLKRASSSGLTANTRLAFSVSNSAPGFKVPPLLRRATTNSSIASSTSSSVSGGIASATERMAGGAGSEGGVKRGGGKNSGVNYFARETERKAKLMKTEKKREQKRFKGAEVRGKVVGGLFGGGKFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYX0</accession>
    <name>A0A3D8SYX0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_02645</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYX0"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14518">
        <property type="entry name" value="DSP_fungal_YVH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016278">
        <property type="entry name" value="DUSP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848:SF4">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000941">
        <property type="entry name" value="DUSP12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="7">
        <location>
            <begin position="4"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="8">
        <location>
            <begin position="77"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="324"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="5">
        <location>
            <position position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000941-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW91480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="351" mass="38480" checksum="7DF21D8C4889875E" modified="2019-01-16" version="1">MALSRVPGDDEIYVGGIFTLRRKSTLVSLGITHVVSVLKYDFKDFEDWEQYAHLSIEVDDVDDENLLGEFENSGAWIEKALKDGKDGKPGKVLVHCAMGKSRSVAIVIAYLLRKYPHHTVATALGLIRQSRPIAEPNDGFMAQLELYKEMGCPGDIEAQPKYQRWLYQREVDLALAAGMAPDKIRFEDEESQDEVKEGGKQVELRCKRCRRTLATTPYLVTHTPKSNMFSTVLNNGPIASLAEINSPPKTPSTNCTSHFLHPLSWMRPALEQGILAGRLECPNAKCGAQIGRYAWQGLRCSCGIWVCPAFSLQKGRVDEIVGAAAPGSGGPSAGGAGGIRLPPGMRPKETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZD7</accession>
    <name>A0A3D8SZD7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 subunit I</fullName>
            <shortName evidence="7">eIF3i</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Eukaryotic translation initiation factor 3 39 kDa subunit homolog</fullName>
            <shortName evidence="7">eIF-3 39 kDa subunit homolog</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="primary">TIF34</name>
        <name evidence="9" type="ORF">BP5796_02293</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the eIF-3 subunit I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZD7"/>
    <dbReference type="OrthoDB" id="24966at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000127">
        <property type="entry name" value="Eukaryotic translation initiation factor 3 subunit I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03008">
        <property type="entry name" value="eIF3i"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027525">
        <property type="entry name" value="eIF3i"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF1">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24805">
        <property type="entry name" value="EIF3I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7 9" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="6"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="48"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="284"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW91128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="339" mass="37989" checksum="CC1588DDBA167C49" modified="2019-01-16" version="1">MRPILLQGHERALTQIRYNRDGDIIFSTAKDQHACAWYAHNGERLGTYHGHQGALWTVDVDPTSTIIATGAADNTVRLWDIKSGKCLKVWEFNTAVKRVEFNEDGSKLLAVTEKRMGFLGTIVVFDIKLDLEAEQTDERAMTITCEDSKATVAGWSFLSKYIIAGHEDGTVSQYDAKTGEQLDNTQAHEPDALITDIQWSPDRTYFITASKDKTAKLINARDLEVMKTYVTDTPLNSASITPKKDFVILGGGQAAMDVTTTSARQGKFEARFYHKIFEEEIGRVRGHFGPLNTVAVDPQGKGYASGGEDGYVRVHQFDKGYFDFTYEVERQVRAQQQQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZE1</accession>
    <name>A0A3D8SZE1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02847</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZE1"/>
    <dbReference type="OrthoDB" id="10535712at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="77" mass="8594" checksum="4062C2566F73AE1E" modified="2019-01-16" version="1">MPQASNFSKTTIGDKALSADEDSELPRYTEKAFEIPEIEDRKNYTTPLIAVCERNVQLDGFVAATKMDDLKTPVSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZE2</accession>
    <name>A0A3D8SZE2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_02831</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZE2"/>
    <dbReference type="OrthoDB" id="9974981at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05259">
        <property type="entry name" value="PCBER_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051609">
        <property type="entry name" value="NmrA/Isoflavone_reductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045312">
        <property type="entry name" value="PCBER-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706:SF1">
        <property type="entry name" value="CIPA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47706">
        <property type="entry name" value="NMRA-LIKE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="6"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW91666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="300" mass="32160" checksum="E3D4E9F7AC94EDC1" modified="2019-01-16" version="1">MSSTIKNVAIVGAAGALGSVILDKLIASGRFNIKVVRRSGSKPSLPAGIEIAEVDFTALDSLKSALAGQDAVVSAVGNEGIESQILLADAAASIGVKRFIPSEFGSNLENPRARQLVVYAPKVKVQDHIIKTSKTTDMTYTFVFNNVFLDWGLQHDFVLSTSNSKPILINGGDLLFSATTLSSIGDAVVGILSHPVETKNRAVRIHDLVTSQNQLLALAKQAAPGRLWEPMIVSLDDMVAKADEMLAKGILDMQTFAPYLSRAALDPNYGGNFEQTDNELLGIKGKTEQDVIQIFKKHLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0F2</accession>
    <name>A0A3D8T0F2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_01373</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0F2"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000127">
        <property type="entry name" value="E3 ubiquitin-protein ligase RNF181"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017629691" description="RING-type E3 ubiquitin transferase" evidence="10">
        <location>
            <begin position="25"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="361"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="71"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="407"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="448"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="466"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="550"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW91979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="561" mass="60663" checksum="EC07B0A5B4471F0C" modified="2019-01-16" version="1">MLRRAGLALSLGALAAYGLRNAMAESHNQMHLDASGPREVVFCHRCEHEWYKDDSPDLTCPQCEGVVTEIVSPESDPRPHLPEPSPDIPPELEELRHHNPWATQGHDSDPDEADIEEHITRGPHGVFIQRTIRSGGRPQRQPGTQDDPAHLINDFQTMIGNLMGPNVRMGQVGRSGPDSIFPPLSGGGAIRGGGFRLGGETGPRVVGGRYTFTTGTLHPRNADGPQPGGPPVDDLATYAPSPPPSGRQLYLVSVTARPDQLARILGSLFGNMGPPSPGGEERHGGMPMGLPGLLAQLLNPQNAVHGDAVYSQEALDRIVSQLMEQHPTSNAPGPASAESISALPKKSLDEKMLGPEGKGECSVCMDDVYIGDEVVSLPCNHWFHEACASAWLGEHNTCPICRKGIDGEANASPQGRRSSRSSPGSGSERSSRRGMFSRRLSDLPSSRNESRNEARLEAIRDMGRLSPTQQGTPTTRWQASDDPTRERNSPSPQAMPGAFDYVPPHPPLRRASQMSDTQRDSRRANTSGSDHSRRSSISGNSGNGGPMNWFRDRFGNSRRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0T1</accession>
    <name>A0A3D8T0T1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_01576</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0T1"/>
    <dbReference type="OrthoDB" id="3560771at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="90"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW92182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="29368" checksum="680D7E1033A69695" modified="2019-01-16" version="1">MTGSDDAAEASHSSEASMTTTPPVPWPPGGGGYDNQMSSWLSSHSFVPVTTSNSSPGPVSTTTLIPSATFPISSILPTPNANTGEQHHGIGIGAVAGIAVGVLILAAAGICWIIWRCCACCGRKRRRETREPHSEVEQHLDTNMLLRGGNRTLSATASPAAASPAAASPASTTISMAAHSVARPPSLDPNAPPPSYDAIRHDAIVPAHAHHRIGGQGQGEDDEFNVVADGKMPLSEIPFEDVDIEALYRFESNSAISSINASRDFAQNHRRGGGNTIGHTNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0W0</accession>
    <name>A0A3D8T0W0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_01599</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0W0"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11059">
        <property type="entry name" value="CYP_fungal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF164">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW92205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="475" mass="54280" checksum="146E319C6EF8A6C5" modified="2019-01-16" version="1">MFLEPWPVLAVAAIFILVSTHLIRRMRSPVASIPGPLYTKFTSIWLMRQEFISNRRPYIHQLHEKYGPVVRLGPNEVSFSSGEAIKEIYASGGSGYDKTEFYTLFKQFGVRTMFSTLVKGDHSQKKRYIAGQYANTNIKRPQVMSGIQDRADAFVQQCRNSAGMSTDAYVSLHCYALDCATHHLFHPHGTHSLEREEDLGLMKELSYHNSLQRYLCQYYFPDIWNFFMKFSKPKRSPDSNDYVLKTNEQSDLGECTLLHKLQASKDFFQKTEMAAECMDHMAAGIDTTGDGLCFLMHQMSLPESRYVQKKLLEEFKQEPEKPLDELPYLDAVVKEGLRCFPPIPMSQPRYVPSGGRTIDGYFVPMGTIVSCQAWTVHRLNEAVYPNGEKFFPERWLEEKGSLERNRLYFAFGAGGRGCTGKHLAIAEVKVLLKEVYSRFTTTIADDMVGSMELSDQVISSRPLDQTCKLVFTEIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T176</accession>
    <name>A0A3D8T176_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_01719</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T176"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006846">
        <property type="entry name" value="Ribosomal_eS30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S30/UBIQUITIN-LIKE PROTEIN FUBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650:SF15">
        <property type="entry name" value="RIBOSOMAL PROTEIN S30, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04758">
        <property type="entry name" value="Ribosomal_S30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW92325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="62" mass="6905" checksum="3BB427B763679C0E" modified="2019-01-16" version="1">MGKVHGSLARAGKVKSQTPKVEPQEKKKTPKGRAKKRITYTRRFVNVTLTGGKRKMNPNPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1R3</accession>
    <name>A0A3D8T1R3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_01864</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1R3"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="63"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW92470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="109" mass="11482" checksum="327C7BE1A57CE69A" modified="2019-01-16" version="1">MDAMRHPTGCRRGATFLPSTLLATAKSEQSARSQNHVAQGLPGTFVTVLGRDRVAPAFLVNRPPSFSSSTGRAAQANASLPHGPISPEARPIPSSMGTYSHVLSKLIMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1T7</accession>
    <name>A0A3D8T1T7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Mitochondrial pyruvate carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_01920</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Mediates the uptake of pyruvate into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1T7"/>
    <dbReference type="OrthoDB" id="869189at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006850">
        <property type="term" value="P:pyruvate import into mitochondria"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005336">
        <property type="entry name" value="MPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14154">
        <property type="entry name" value="UPF0041 BRAIN PROTEIN 44-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03650">
        <property type="entry name" value="MPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW92526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="177" mass="19486" checksum="A9D1437C4E44882D" modified="2019-01-16" version="1">MPPSTVFRAARPVFRSSQFFTQQAYRTQGGRVAGRRCQSTASQATEAAPGLFKRMWESPVGFKTVHFWAPVMKWALVLAGIADLTRPAEKLSLTQNAALTATGIIWTRWCLIIKPRNILLATVNFFLGCVGVAQVTRILLWRRSPEGKAALQLEAAQQSAVDTAKDVKGKVEDVIKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T249</accession>
    <name>A0A3D8T249_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Actin-related protein 2/3 complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_01973</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5 6">Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
            <location evidence="6">Cytoskeleton</location>
            <location evidence="6">Actin patch</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the ARPC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T249"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1460.20:FF:000001">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008384">
        <property type="entry name" value="ARPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629">
        <property type="entry name" value="ARP2/3 COMPLEX 20 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05856">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039100">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR039100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW92579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="169" mass="19650" checksum="DFC7735D94AD5998" modified="2019-01-16" version="1">MSQSLRPYLQCVRSSLTAALCLSNFASQTSERHNVPEIEAQTSPEVLLNPMVVARNENERVLIEPSINSVRISIKIKQADEIENILVHKFTRFLTQRAEAFFILRRKPVKGYDISFLITNYHTEEMLKHKLVDFIIQFMQEVDKEISEMKLFLNARARFVAESFLTPFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T2F3</accession>
    <name>A0A3D8T2F3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF967 domain protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02005</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T2F3"/>
    <dbReference type="OrthoDB" id="2209940at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.150">
        <property type="entry name" value="Haem-degrading domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005624">
        <property type="entry name" value="PduO/GlcC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038084">
        <property type="entry name" value="PduO/GlcC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010371">
        <property type="entry name" value="YBR137W-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28255">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28255:SF1">
        <property type="entry name" value="UPF0303 PROTEIN YBR137W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03928">
        <property type="entry name" value="HbpS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143744">
        <property type="entry name" value="GlcG-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW92611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="384" mass="42722" checksum="9FBA784F8F98E02A" modified="2019-01-16" version="1">MSSFCGLRLKTAKRQVIHKRGHSLLSFAAEHAITTPANNTVFDPDSDNIYNKVVKYDQSRSYSTEEGNTFWAPAREDQLSIILEVLDAETRRTPGNELDELNWGKPPKVPHFKPNSLQRVREVNESSNENSPAHTRASSRAGLPKPQTPKLLKEHGEQRPVLLRRKATGFGLSSQFQHIEMSDIRGESRSRGEGSRRGKSAERRGSFETSAPPTPNSQRGIRPISSPPRDLDAIARIDASLVFEHFTTADAWALGCALRSRLILLPTPVVIDISLANQNQVLFHTCTHTGVMPDNDSWVSRKRKTVLRWGVSTWYMSCKFEGDERAFAAKYGLGEKGGEYAIHGGGVPIRVRGVEGVVAVVVVSGLKQDEDHGVIVECIRELYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T2M3</accession>
    <name>A0A3D8T2M3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_01642</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T2M3"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000726">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF83">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="380"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="569"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="33"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="98"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="119"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW92248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1014" mass="115597" checksum="75844A8D53033C24" modified="2019-01-16" version="1">MGAAKKYALLPMEEEDLGPAKVIEKKDKRRHGERSSSRREKSTRDRGHDRSRERSPRLETERRSKTIRRREANEADFEDRWGDEEYVSEEQPEFQESASKRVKTDHEPEQELDMSEEAVAERERRRDLAERDEFAKRLHSKDADKTKKLVEDRSSTKEGQVLAQRRRLAEDAAARSAALPDLRERSRQEYLKKRETERLALLRKQVAEETEELRSGVRLSEKEKAEFAKNREVLRIAEERLRIDDHLDGYAMPEDYITEKGKIDKKKKEDAMYKRYVDRDEYGQERFVTEHEEWEREQAAKAKAQIASTERVDNGEYDYVLDEEQGIKWVMDSRLPGEGKGLSKEERFLAEQLKAAEKKALSMEETRKSLPIYQYRDQFLAALEQYQILVIVGETGSGKTTQLPQYLHEAGYTKEGLKVGCTQPRRVAAMSVAARVADEMGVKVGNEVGYSIRFEDSTSDKTILKYMTDGMLLREFMTEPDLGGYSAIMIDEAHERTVHTDILLALVKDLARERPDLKLLISSATMNAAKFAEYFDDAPIFNIPGRRYPVDIHYTPQPEANYLAAAITTVFQIHTTQGKGDILVFLTGQDEIEAAEQNITEISRKLGSRVPELIICPIYANLPSELQSKIFEPTPDGARKVVLATNIAETSLTIDGIVYVIDPGFVKENIYNPATGMSKLVAVPCSRASANQRSGRAGRVGPGKCFRLYTKWAFMNEMEESTTPEIQRTNLNSIVLLLKSLGINDLLEFEFMDPPPTETLIGALNQLFALQALNHQGELTKMGRQMAEFPTDPMLAKAILAADKLGCVEEVLSIVSMLSEASALFFRPKDKKIHADSARARFTVKEGGDHLTLLNIWNQWVDSDFSPIWSKENFLQQRSLTRARDVRDQLAKLCERVEVTLSSVGAAELVPIQKAITAGFFPNAARIQRGGDSYRTVKNNTTVYIHPSSVLMDSNPPIKMVIYHELVQTTKEYMRSCLPIKPEWLHEAAPHFHKKKDLEALEDRKMPKSERSRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7R6</accession>
    <name>A0A3D8T7R6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_00328</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7R6"/>
    <dbReference type="OrthoDB" id="10586621at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="349"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW94565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="430" mass="47332" checksum="E9B29A0F298F9728" modified="2019-01-16" version="1">MQPRRPSDCSAPSTFAQHTGGKPSPLAPPHAILILGSASAALLRGSTSKAELRTGRTGRERAANGAFLFPSPSRRMGVVCRDAINTRQFNTSTLYADPTTILGHHRAVLERKWQPWSRLMTGCLDGPAGYLIKWPPEMSTLVAIKFEALQSKYSGQRIGATRDSTERLHRPTCPPKRKHYQYCHEALAVIDKPAPPIREATIQQWWTVRTVYDLVAMPLQPKTRMGRRKMHATHSGSPAQDTRTPGTLLSICIGFPKEQASFLEPAEDLMHETGTASPAAAASWGDKILILPSVHGRKPPPTEFEVKADMRNPVQRHVSDKVKVSRCPMPTLFRPRGLQRAAWKKQLFAKKPSASDAAPEAACRPTQGPYPLHSSGREEQSSRRPPPKLQGQPPTAPGGRNLQSQPRRRRSPKARPKSTLGGESNSSLTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7W1</accession>
    <name>A0A3D8T7W1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 12">3,4-dihydroxy-2-butanone 4-phosphate synthase</fullName>
            <shortName evidence="12">DHBP synthase</shortName>
            <ecNumber evidence="3 12">4.1.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_00426</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18457"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15740"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="4.1.99.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="12">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="12">Binds 2 divalent metal cations per subunit. Magnesium or manganese.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Cofactor biosynthesis; riboflavin biosynthesis; 2-hydroxy-3-oxobutyl phosphate from D-ribulose 5-phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 12">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">Belongs to the DHBP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.99.12" evidence="3 12"/>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7W1"/>
    <dbReference type="OrthoDB" id="60371at2759"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00399"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008686">
        <property type="term" value="F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.870.10:FF:000002">
        <property type="entry name" value="3,4-dihydroxy-2-butanone 4-phosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000422">
        <property type="entry name" value="DHBP_synthase_RibB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00506">
        <property type="entry name" value="ribB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327:SF18">
        <property type="entry name" value="3,4-DIHYDROXY-2-BUTANONE 4-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21327">
        <property type="entry name" value="GTP CYCLOHYDROLASE II-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00926">
        <property type="entry name" value="DHBP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0318">Glutathionylation</keyword>
    <keyword evidence="10 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 12" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0686">Riboflavin biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW94663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="238" mass="25841" checksum="125C96E8730ADF33" modified="2019-01-16" version="1">MPTSQVPADVANQFDTIEDTIEAFKNGEFIVVLDDLSRENEGDLIIAASDVTTEQMAFMIRYSSGYVCAPTTPSILDKLDLPPMVTNNEDPKGTAYSVTIDASSDLTTTGISAHDRALTCRTLADAKAVRDSFRRPGHVLPLRAKEGGVRERPGHTEAGVEFCRLAGKPLVAAICEMVEDGEEVAGQALRREPGMMRRDGCLAFGKKWGLKVCTIEDLVAYVEKKEGKFVPKQTNGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7Z9</accession>
    <name>A0A3D8T7Z9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_00442</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SWD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7Z9"/>
    <dbReference type="OrthoDB" id="27537at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="WD40 REPEAT PROTEIN SWD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="59"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="138"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW94679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="378" mass="41934" checksum="57911DA56E0640BB" modified="2019-01-16" version="1">MSSTPMAIDSPIGINGHPSVVRPPPATGKLTDLISFYRPNKLFRREPAKGSKSIREPNVLSIDFDDQGNLMLTSESDDTLQIYNVQEGKAQKTCYSYKYGASNAIFTHKDSCIIHSSTKLNHTIRYLSTHDNNYLRYFEGHEENVTCLSLHPGSDNFLSCSEDNTLRIWDVGSKNVCGILNLNGANLAAWDPSGNVFAVASAKAGTILLYDFRYYDHAPFSAFDIYPMAQTYNMSAVGKGWNKLEFSNDGKSILLGTTGRGHFLLDAFDGSMKSFLARERGGTRRLGAGDHLTADEDLATTSGDCCFSSDGRYVLSGQRKENVLVWDTLMTDPERKIKPIHEIEHKGEAAVMGFNPRYNFFATGDKEVVFWTPDLNAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8D7</accession>
    <name>A0A3D8T8D7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative acetoacetyl-synthase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_00615</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8D7"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030729">
        <property type="term" value="F:acetoacetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005914">
        <property type="entry name" value="Acac_CoA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01217">
        <property type="entry name" value="ac_ac_CoA_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002937">
        <property type="entry name" value="PRK03584.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42921:SF1">
        <property type="entry name" value="ACETOACETYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="6">
        <location>
            <begin position="47"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="5">
        <location>
            <begin position="115"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW94852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="680" mass="75059" checksum="79107CDF76A76A4E" modified="2019-01-16" version="1">MGFMASDTPASSDLAVELWRHPNPASARMWEFKDVINQKYSLNLDSYDDLYRWSIANISDFWAETWHFTGIVASKPFDRVLESNAPMFPRPDFFAGSQLNFAENLLFPANTIIDPNSPAIISATESIRFTTTWAELRELVRKCSLALRNLGVQPHDRVAGFLGNHTNTVVAMLAATSIGAIWTGVSPDTGVGAVLDRLVQIEPIVLFADNAVEYNGRFHESITKTRDIVKELTELKAVVLFKTVASMPVSIDNFVVAKGNAWIYEDFLQSATSPSGALTFTQLPPSHPVYILYSSGTTGKPKCIIHSAAGTLIQHKKEHILHCDIRPTDKVFYFTTCTWMMWHWLISGLASGATLILYDGSPFKPNSNHSMPKLIEELRITHFGTSAKYLSILEQNNAYPIKDGIDLSTLRAIYSTGSPLAPSTFSYVYSAFPATINLGSITGGTDIISLFGAPNPLSPVYKGEIQVRGLGMAITAFDPSGQPSDAGEPGDLVCTKPFPCQPVGFFGAEGEAKYKSSYFETFPGVWHHGDFVRFNPETGGILMLGRSDGILKPSGVRFGSAEIYNILLKYFAAEIEDALCIGRRRETDPDETVVLFLKMVDGQECTEELKDAIRKEVRRDLSARHVPGVIDECFEIPVTTNGKKIEVAVKQILCGMNVKTSASVANANCLDWYREWAKMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8X8</accession>
    <name>A0A3D8T8X8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_00782</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the PTH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8X8"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1470">
        <property type="entry name" value="Peptidyl-tRNA hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001328">
        <property type="entry name" value="Pept_tRNA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018171">
        <property type="entry name" value="Pept_tRNA_hydro_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036416">
        <property type="entry name" value="Pept_tRNA_hydro_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00447">
        <property type="entry name" value="pth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17224:SF1">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01195">
        <property type="entry name" value="Pept_tRNA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53178">
        <property type="entry name" value="Peptidyl-tRNA hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01196">
        <property type="entry name" value="PEPT_TRNA_HYDROL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0820">tRNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="21"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW95019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="263" mass="28513" checksum="3B87FBA2876536A8" modified="2019-01-16" version="1">MTSREPTQISVQESWDTTPTKKTKNKSRRAKNSPVPASSPERHPSNNDAIITPTLPRLTYSSHLPMATKAPLRLLVCSIGNPAPYLQTYHSAGHLVVSALQRSLAYPPFQKSRAHGNGLVSEGLTPDGARYTLWQSASLMNISGPGVVAAWRTFLKSSGGGTGEDARLVVVHDELELALGQVRVKKGEMSAKGHNGLKSIKESMANTGQEWWRIGVGIGRPLSREKDDVARFVLSKMKEGDRERVLGCVRKVEAELGRLAAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9J0</accession>
    <name>A0A3D8T9J0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">26S proteasome regulatory subunit 7 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_01005</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">The 26S proteasome is involved in the ATP-dependent degradation of ubiquitinated proteins. The regulatory (or ATPase) complex confers ATP dependency and substrate specificity to the 26S complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9J0"/>
    <dbReference type="OrthoDB" id="1937997at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000005">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048723">
        <property type="entry name" value="OB_PRS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21236">
        <property type="entry name" value="OB_PRS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="214"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="11"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00067449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW95242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="439" mass="48938" checksum="0AD43054B060E980" modified="2019-01-16" version="1">MPSAKGANWESYKKDFEDEDTPEKKITPLSDEDIQVLKTYGAAPYGAALKKLEQQIKEKQTSVNDKIGVKESDTGLAPPHLWDVAADRQRMSEEQPLQVARCTKIIQDDKDAEKSKYVINVKQIAKFVVNLGERVSPTDIEEGMRVGVDRNKYQILLPLPPKIDASVTMMTVEEKPDVTYGDVGGCKEQVEKLREVVEMPLLSPERFVNLGIDPPKGALLYGPPGTGKTLCARAVANRTDATFIRVIGSELVQKYVGEGARMVRELFEMARTKKACIIFFDEIDAIGGARFDDGAGGDNEVQRTMLELITQLDGFDARGNIKVMFATNRPSTLDPALMRPGRIDRKIEFSLPDLEGRANILRIHAKSMSVERDIRWELISRLCPNSTGAELRSVCTEAGMFAIRARRKVATEKDFLSAVDKVIKGNLKFNSTATYMQYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q417</accession>
    <name>A0A3D8Q417_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Glycoside hydrolase family 61 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_13061</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000025">
        <property type="protein sequence ID" value="RDW56596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q417"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF34">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017548097" evidence="6">
        <location>
            <begin position="18"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="7">
        <location>
            <begin position="18"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW56596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="267" mass="27978" checksum="72B795C188E2EA83" modified="2019-01-16" version="1">MLTDFVLLGLWASLATAHGTVSGVVADGVYYTGYSLNFQYMNPIPTTAGWSIPKDQSLGPLTPDQFSSPDINCHVGATPGQTSVAIKAGGQLELQWTPWPESHKGPVMDYLANCNGPCETVDKMTLQWFKIDGVGLIDNSVQNGKWASDVMIANNNSWTVTIPADIAQGNYVIRHETIALHEAGNQNGAQAYPQCVNLAISGSGTAKPDGVVGTALYKATDPGILINIYTTLSTYPVPGPTPYSGAVSLSQTAPAAPTASATGVPPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q482</accession>
    <name>A0A3D8Q482_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_13097</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000025">
        <property type="protein sequence ID" value="RDW56632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q482"/>
    <dbReference type="OrthoDB" id="4314040at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF1">
        <property type="entry name" value="TRANSCRIPTION FACTOR, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW56632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="54917" checksum="6229DDBA8BE6E1DF" modified="2019-01-16" version="1">MAQQRAVRNAKSCDLERPACRECARLNYNCPGYRHELDVVLKDQTASVVSRYRNQRHKPPKLPAKVACVASETWSLPKDIAYGLESHALAFLFSANTSMGARDGRTIYGLLDFLQPLYRGVTPDSPLAVATLWLAVSMMGNSGIDTSHPLEVQLMTKVIQRILTAIQDPIKSVEDETLTAVILVTYGGYLRDRRYGARSFNTVHQDGAEALVRKRGLLNFQDRRSLALFNAVRHNAVNLAISGARETRNWDLWNLHGETRLLCDSYSPATELDACGCTMVILKSRLRYEDFHTGKSLRKGLLELLQRLHSWQYSVPPEWQPRQIPFGTFSYPSPEVSYLFNQWYLLQLMVSHLKKEVEMRTHVIETPSPPSWCEMEWMNNIKASENSYLRHGSNKDNTLGLKVPNSSAYIDIDESFSGATIQLCCCSPFGSRLLGQTLDSLDRAISEAIEKLNLPSQVDLHYRDILCWTRRERDTIRQANNFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q5M2</accession>
    <name>A0A3D8Q5M2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_13044</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000024">
        <property type="protein sequence ID" value="RDW56977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q5M2"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW56977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="93" mass="10101" checksum="DC1ED87FF1FEC287" modified="2019-01-16" version="1">MAPIPAPTPIPAFAPVDRLRGIGADVLVVADVLMAVEDSDFEDIKDVEDVEVEDVEVEDVEVEDINVVDVNVNTNDVDIEDVDVEVVIERSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q9B4</accession>
    <name>A0A3D8Q9B4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_12346</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q9B4"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017494108" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="31"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW58416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="555" mass="59707" checksum="E641E3B0AB934B72" modified="2019-01-16" version="1">MFRNLKVATLLLGACSVLAAPSYGRDASNLTVTLKNGTYGGVHSPQYDQDYFLGIPYAQPPVGDFRFLVPQSLNSSWAGTKSATSYPSACVGYGSDDLPYTSISEDCLYLNVVRPSGYESETLPVAFWIHGGGLYEGSSIDQRYNLSFIVQKSVDVGKPIIAVSINYRLSMWGFITGEEVLESGNANLGFRDQRLALHWVQENIAAFGGDATKVTIWGESAGALSVGMHLTAYGGRDDGLFRGGIMESGNPVFYGNFNAWNPDDFTTAAAAMGCNSTADKLQCLREVPYETLNNWVNSTGQSLSWQPLIDGDYIQGYTSLQLAKGEFVHVPIISGANSDEGTAFSPTGVNSSAIFLANLEASLPAASASAIAAAYPVNITNGAVPTGLPASWVPPDSLALGSNWRRSAAYTGDYNFIANRRLTCETWAKNAVSAFCYRFNTVPNGISTYIGATHFQEVAFVFNNKNGLGYPPVSEDPFEGEPQSYFELSDKMTTAWATFIHDGSPGSFWPSYAVGNGTNFVFDANATGLGYVEPDTFRSAGISLINSWSSELYGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QEA7</accession>
    <name>A0A3D8QEA7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">L-xylulose reductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_11673</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QEA7"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05352">
        <property type="entry name" value="MDH-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF13">
        <property type="entry name" value="L-XYLULOSE REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW60067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="293" mass="31235" checksum="40CD94C97FF60AE3" modified="2019-01-16" version="1">MAGNAMNGGDFSHNNTTAPEATRVMPLFSLKGRTAIVSGAGAGIGLAIAQCLAEAGANVAIWYNSNKKAIAEAEKIEKEYGVKCKAYQVNVLEFAPVEAAINEIVKEFNGRLDIFIANSGIPWTQGPALDGELDHYRKVVATDLDGTFYCARAAGIHWRRQKKEGTTIDGKKLEGFTGGSFVATASMSGHIVNIPQLQAAYNAAKAGVIHLCKSLAVEWVGFARCNTISPGYIATEISDFAPAETKKSWRDKIPMGREGEAHELKGAFLFLASDASSYCTGTDIICDGGYCLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QEQ6</accession>
    <name>A0A3D8QEQ6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_11899</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QEQ6"/>
    <dbReference type="OrthoDB" id="429143at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF260">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="55"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW60293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="200" mass="21928" checksum="CD60912A174E25DA" modified="2019-01-16" version="1">MEEQPPIPASSTAIPQERYGFPKPDGYSLSYWLQGVQGDPLLNHRTTPEVPPSADIVIIGSGITGTSVARHCLTTWPEKSIVVLEAREFCSGATGRNAGHCKPDQFRGFKRYETAFGTEQALKILQNEGQTWSDLVQYVRENDVDCDLWVGNTLDVPVTPEAAEIAKDVYDRFKAAGGKTDHIEVTPEPAEAAKVSPRLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QES3</accession>
    <name>A0A3D8QES3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA (guanine(37)-N1)-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA methyltransferase 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="primary">TRM5</name>
        <name evidence="12" type="ORF">BP5796_11766</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="10">Predominantly in the mitochondria and in the nucleus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRM5 / TYW2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="10"/>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QES3"/>
    <dbReference type="OrthoDB" id="408788at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070901">
        <property type="term" value="P:mitochondrial tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.110:FF:000001">
        <property type="entry name" value="tRNA (guanine(37)-N1)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.110">
        <property type="entry name" value="Met-10+ protein-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03152">
        <property type="entry name" value="TRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056744">
        <property type="entry name" value="TRM5/TYW2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025792">
        <property type="entry name" value="tRNA_Gua_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF36">
        <property type="entry name" value="TRNA (GUANINE(37)-N1)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25133">
        <property type="entry name" value="TYW2_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 10 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 10 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="11">
        <location>
            <begin position="139"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="268"/>
            <end position="269"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW60160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="463" mass="52369" checksum="4109DB1624D0A585" modified="2019-01-16" version="1">MSLFRPPIVRSASGLLDRSLFSKTIPLAAARIANVKNVSKIRAKLEGSREVLKLERTINVRPDPDSALASKGGRCLLLKPEVKVGDSTTWSDTLKEAVNLNEVGVIPYNLELDYKYWTYQDIMESVLPEEDQGEIPTGFAIVGHVAHLNLRDAYLPYKHIIAEVIADKNNGIRTIINKVNDVGAESEFRTFAYEVLYGPDDMNVEIKEQECLFRFDYSKVYWNSRLNTEHERLVEAFEPGVAVCDLMAGVGPFAVPAGKKKVFVWANDLNPDSIASMRDAVVRNKVQAYVRPHCENAHKFIYSAVDDLLNLTATSQNTVTIPGTASSRNLPKEERERQILERSKTITIPQTFSHFVMNLPATAIEFLGSFNGLYRDHAELFTPHTNVKLPMIHVHCFSTKSEDNVREGIDICNRISKYLDYTVTPQDKELVIYEVRDVAPNKRMFCASFRLPAEVAFRERRNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QFB7</accession>
    <name>A0A3D8QFB7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Superoxide dismutase</fullName>
            <ecNumber evidence="13">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BP5796_11720</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="13"/>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QFB7"/>
    <dbReference type="OrthoDB" id="239262at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.990:FF:000001">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.55.40.20:FF:000004">
        <property type="entry name" value="Superoxide dismutase [Fe]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050265">
        <property type="entry name" value="Fe/Mn_Superoxide_Dismutase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404:SF29">
        <property type="entry name" value="SUPEROXIDE DISMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11404">
        <property type="entry name" value="SUPEROXIDE DISMUTASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 12 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 13" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="14">
        <location>
            <begin position="6"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="15">
        <location>
            <begin position="101"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDW60114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="218" mass="24100" checksum="3C0116A630B2E8AF" modified="2019-01-16" version="1">MSSVAKYTLPALPYAYDALEPHISKEIMTLHHSKHHQTYITNLNNFLQTQSTASLAGDLIKQLSLQQAINFHAGGHINHTLFWENLAPASSSSTSPDCAPKLVAAINTRWGDLSTFQQKFNTALLSLKGSGWGWLVQDLESGALEVITSRDQDVVPATKKPLLGVDFWEHAYYLQYLNDKAAYAVGIWKVVNWKIVEKRFTGSTDIVFGSLVGLKAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QFQ8</accession>
    <name>A0A3D8QFQ8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit D</fullName>
            <shortName evidence="5">eIF3d</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_11860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QFQ8"/>
    <dbReference type="OrthoDB" id="16538at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098808">
        <property type="term" value="F:mRNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002191">
        <property type="term" value="P:cap-dependent translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03003">
        <property type="entry name" value="eIF3d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007783">
        <property type="entry name" value="eIF3d"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05091">
        <property type="entry name" value="eIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016281">
        <property type="entry name" value="EIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="108"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA gate" evidence="5">
        <location>
            <begin position="304"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW60254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="576" mass="64023" checksum="BF6D29C7C83255BC" modified="2019-01-16" version="1">MAPISISDIVSALPSEDGWGPPTSTETTLDGVPYAPYSKGDKLGRMADWTAEGKDGRDGRGGRQQYNRNYRDQQVYGAGTSSLFAVQVAEDESSFSVVSNTRDSVKTRFGRGGAFTRGRGQRGGPANARGRGQFQRVGGRGGQQGYGNYDNRGGRGGARGGRRFGWKDYDKPQRNRDASVNIKPDWKMLEEIDFNRLAKLNLDTDDGEDLDNYGFLYYYDRSFDKPAVKSAERKLNVVDRAAYNVTTSSDPVIQELAEKDEATIFATDSILSMLMCSPRSVYPWDIVIVRQGNKVFLDKRDNATLDMVTVNENAADAPMDASEGSKDSINQPSALAEEATYINHNFANQTMLENENQKVEMAHENPFYNPAEETEPPASKAYKYRRFDLSLNDEDPVHLIVRTEIDAVQKNAISGEDQFITVKALNEFDHKAQGSGGALDWRTKLVSQRGAVVATEMKNNSCKLARWTVQSIMAKADVMKLGFVSRANPKTNDKHVILGVVGWKPRDFAAQMNLSLSNGWGIVRTIADMCLKREEGKYVLVKDPNKQILRLYEVPAGSFEEEELGDAIEEVEVEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QHL8</accession>
    <name>A0A3D8QHL8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7907 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_11235</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QHL8"/>
    <dbReference type="OrthoDB" id="3515453at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057229">
        <property type="entry name" value="DUF7907"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25484">
        <property type="entry name" value="DUF7907"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017616936" description="DUF7907 domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7907" evidence="2">
        <location>
            <begin position="35"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW61343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="201" mass="22283" checksum="0C6A8339DFA06B56" modified="2019-01-16" version="1">MKFSTFLQAFALASTAVAQFDVQSAPFKLVLLSECELNGTLLITCHEGAAIEGLCLGDKDGATPSINEVFQFNYSSENFDNKTYNIPGYVTWILPASNINVSSAFGLNYSPTSNVAIPLFFPGSDFATTVSFDMYEYLNVQGYIDDTKTPITGQGSTFVEYRWYICDTYWGYAYTTLAWVMGNGKPQNPTCTKVKVKRVFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QI49</accession>
    <name>A0A3D8QI49_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_11293</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QI49"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF50">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="92"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW61401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="765" mass="85261" checksum="61F38D508E74CACD" modified="2019-01-16" version="1">MTGGAPRSGTTASKPLSCTNCRQRKIKCDRTNPCRQCQAAGIECVTPTRVRAPRSSRQSKIAARDSELLRRVNRLESLLSKSDLARALLSEEADSQTATTELPPDSAAPIPSVADEVSDVPPSGERMDEQYAHFIKQQRNDIKLQSGDFIKSIGSEVCGLRRFLVQSLDEEEDGDEQLSFNDSPPNMIFGSPNSSLSTEGFYPSEEHRDRLFSTFFVNVHPVCRILHNPAFALHAESSKEFLNEDGIYKFPSMEAVSFAVYFAAIVSMTPNECWDNFQEDRNVLLSKYQHATEVGLLKADFSNTVEIVTLQALVIYIMALRAHNKSRPSWSLIGLAIRIAHGQRLHRENDGRPLSTFENEIRRRLWWQIIVLDVRAAEDRGSDPMILETSYNTRMPCNANDADYEFSSSKPKYATPDPSLIVKLCSGDQTRLCYASDKPLKDKFGITEMTFNLLSMETAVVYRKINFIPPGSQTMLTPNQKEMLVKECVDKIENKYLAGCDPTDKNVWITYMYGRSLVLKLWLAVQFPLHSVDSGRASLMSTSGLQNAISYLTLMEVLDKHSEGSGVQWYFKSQVPFHAAAVSLAMIIRQPQGPLADQAWAVIERNFAKWAERVAGAKDGMPWGPMKILFQKAGATRQQQRLPSMTPGGDTASSISSQRSLDVLPELPNLNLSETTSTYTVPNGGRLFNVFLPTNTPPAPAKFGILPSIDMSAPDPSMPYMGTPNMDMDLDVSGDPANWADWNQFILDTNVDMTDPGDQMWGNIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QII7</accession>
    <name>A0A3D8QII7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_11372</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QII7"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.330:FF:000040">
        <property type="entry name" value="Chromosome 21, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-haem dioxygenase N-terminal" evidence="3">
        <location>
            <begin position="34"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="2">
        <location>
            <begin position="205"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW61480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="42058" checksum="ADAF9ADFD85785E9" modified="2019-01-16" version="1">MAQVLPAQAGIARPLQYEQVAETKHDLDWADLVTIDLSKFDSPDGKEELAKQLFNAIQQIGFFYIINFGLSQQEVDNQFAIGKEFFNLSTAEKLKYRADLENGGYNGYKPLGLREIVPGKFDNTEIYNIPKFIPEYARPYPEVIKENWPDIQKFGQHINDEIARKLLVLFAIILELPEDYFLDRHRYTERSDCHLRYMKYHHRAPEENKELGNVWVKGHTDYGSVTLLFRQPVAALQVRTPQETWKWVKPYPGSITVNIADSLSFLTNGFLKSSIHRVVAPPPDQEHLDRIGVLYFVRPEDKLPLIPVESPVLKRLGLKKTDSSDNGEIVTAGEWVRARVAGNVSGKNGSRDAGDHEVIKGKKAKYYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QJ15</accession>
    <name>A0A3D8QJ15_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Efflux pump dotC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Dothistromin biosynthesis protein C</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_11552</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Efflux pump; part of the gene cluster that mediates the biosynthesis of dothistromin (DOTH), a polyketide toxin very similar in structure to the aflatoxin precursor, versicolorin B. One function of dotC may be to transport early-stage dothistromin biosynthetic intermediates from the cytoplasm into vacuoles, thereby affecting the rate of dothistromin production.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QJ15"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000014">
        <property type="entry name" value="MFS drug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF102">
        <property type="entry name" value="DRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G08530)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="227"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="294"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="336"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="545"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="77"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="577"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="14"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="581"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00057269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00069956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00083178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW61660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="600" mass="64228" checksum="108418565CE35F32" modified="2019-01-16" version="1">MYSHRSTPEACLPEAERETHADPILDREEKRAVHDSDSSHAATINANENASSPDAANGMPMPPEPEASRTKLQTSIIMVCLCASVFLAALDTTIVTTALPTISEYFHSSAGYTWIGSAYLLANSASIPSWGKLSDIWGRKPILLGACSVFFIGSTLAATSVNIGMLIAARAIQGIGGGGLLVLVNICISDLFSMRNRGQYFALVGMTWALASALGPVLGGVFTEKVSWRWCFYINLPITGTVTILLFFFLKLDSPRTPVWDGLKAVDWVGSLTVVGGTLMLLLGLELGGVSFSWGSPTVVCLIVFGVVVTGLFVLNEWKLAKYPVMPTRIFSNISNAAALGACFSHGFVFISASYYLPLYFQAVMGASPLLSGVYVLPYALALSFCSVATGIFIKKTGMYLPPIWFGFTIMTLGVGLFIDLPVTTNWAKVILFEIVLGIGVGPNFQAPLIALQSHVQPGDIATATATFGFVRTLSTAISVVIGSVVFQNQMKNHYTTLVGPLGAALANELSGGSAGASVGIVKQLPPAQKAVAQEAYYQSLRTMWIMYVAFAGLGLVISLFIGRHVLSKEHQVTKTGLAAEEEKRKLNQQKKVKDEEPVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QL32</accession>
    <name>A0A3D8QL32_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_10801</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000002">
        <property type="entry name" value="Probable polyketide synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF13">
        <property type="entry name" value="POLYKETIDE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="8">
        <location>
            <begin position="37"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="9">
        <location>
            <begin position="961"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="2149"/>
            <end position="2226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="5">
        <location>
            <begin position="961"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="5">
        <location>
            <begin position="1125"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="17"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="5">
        <location>
            <position position="993"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="5">
        <location>
            <position position="1190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW62499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="2240" mass="243386" checksum="92257B9AA63ECC6C" modified="2019-01-16" version="1">MAPSAIPIDGNEWLHSEATNGDFSPKTNVEESQPSNMMPIAIVGMGCRLPGDVSSPEEFWELCSRARSGWSPIPKERFNHEAFHHPNPDKLGCYNPEGGHFLKEDLGLFDAPFFNLTEKEAISMDPQQRLLLECTYEALENGGIPKHTLVGKDVGVYVGGSFADYELRNCRDTDTAPMYQATGCASSLLANRLSYYFDLAGPSLTVDTACSSSLTALHMACQSLRMGESSQAIVASCHLNILPDYFITMSMSSLFSNEGKSFAFDHRGSGFGRGEGVGCVILKPLDEALKANDSIRAVIVGSGINQDGRTKGITMPSGDAQVALMKSVYEKSGLNPSDTGYIEAHGTGTKVGDPIEASALHEVFGEGRTAKKPLFIGSVKSNIGHLEGASGVVSVIKTAMMLEKGFILPNCNFEKPNPKIPFDEWNLKVPTNQRPWPPGKKYASINNFGFGGANAHAVLGKAPAVSKVVPRQNIDGPVSTTQGPTKRIYVLSANDKVTLEKQQNDLTIYLEQRPEVFQNSLLPNLAYTLGQRRSVLAWKVAVPAYSSAELIATLAGNIVTPSRSVKAPKIGFIFTGQGAQWHAMGRELLESYPIFNTTMRKIDDCLSKLGAQFSLLDELSTEAEASRVSAAEISQPACTAVQIALVELLKSWNIHPSAVAGHSSGEIAAAYATGALSLEDAVAIAYYRGQSIPQLKSRFPDLKGAMMAVGGSADEINSMLEQMTCKGKVVVGCINSPASITASGDEDAINQLQQLVEEKQLFNRKLRVETAYHSHHMNLVAEQYAESIKTVSSREATQPTLFHSSLLGRQISTSELGPSYWVDNLTSPVRFSEAVQSMCKPADETSPDPGVDVLVELGPHAALEGPIKQILKAVGGRAIKLPYVSALLRNKNAVDTALNLAATLFMKGAPVDFEAINYPIPPTKRPSLLTNLPKYPWNHSRKYWHQARIAEQHENRQFPRNDLLGTLANYSNHLEPIWRNIINADDMPWVRHHKMQDMTVYPMAGYMTMAMEAAAQRAVMRNVAFDKFELREITVSRPLVIAEGSNVEVNVTLRAHAEGTRSSSDSWDEFRVFSWASDRSWIEHCRGLISVQKNTDNNVIDGAQQKLDEKLLLLSEIDTINKASNCNVDTTQMYETLSAAGAGYGKTFQGLENCRASDSHAVADLVIPDTAAVMPMGHETDCIIHPALLDQFIQIVWPIFGAGRKGLDCFYMPSFVESMSVSTGITRKSGDRLKVFGSGRPTPFNPSPTKFSFFATDYDGRNEGLLSVTSLVMTPVLNGDSGSGAVTSRELCYKLEWEPAFSQKDEVDVQENSAASPAATTDAVPDQEIAIVCEEAQQSLVSSLQKLICDFTNKTPVVGSLGKMSTEGKICVVLSELDHPTISAMDKPEFEAIQNMVKGASGILWVVRGAYTESENPNSQMVVGMARSIQSETLLKFATLDLGTSPQLSETESAAKIFQVFQRTFSSTSSSIGLDLEFAERQGKLMVPRVVDDWEMDKFVHQETQDFAPPDLQPFEQEGRPLKLAIGTPGALDTIYFADDLVAGQDLPEYEVEIKVEATSMNFKDIMVSMGQLNQPYIGVECAGIISAVGSRVTGLAIGDRVCAMSEGAYSTYARCLGTSVQKIADDMSFVDASTIPVVYCTAYYSLFDLGRLAKDEKVLIHAAAGGVGQAAILLCQMVGAEIFATVGSVTKKEFLMAEYGLPEDHIFFSRNTSFAKAIRRATKGRGVDVVLNSLAGDQLRETWDSLAHFGRFIEIGKRDIVGNTRLEMARFEYNATFSSVDLTVVAAERPQIMKRLLADVFDLLSTGSIRPVSPITIFPISNVESAFRTLQSGKTMGKVIVVPNPGDQVKAVPRKTPNNLLKSDATYIIIGGTGGLGRSMGRWMIEKGARNIALLSRSASTSGKVGELIEEAKTKNARIVVRSCDVCDREQVNTLLTEGIREMPPVRGIIHAAMVLDDVLFEKMAWEQWDTVVKAKVSGAWNFHYALADRPVDFFICLSSAAGAVGNRGQAAYAAANCFLNAFVQYRNKHGLAASSIDLTAVSDVGYLAENAAKQAQVAENLGSETISEMEVLALIGAAIRGDLQKNCNNHCITGLKIGSKAQDLFWVDDAKFGYLKKAALAKQEEDETALPTVSLASALKASTSKEQALQLVCEGLMTKVSAVLMVPREEMDSSRPIVAYGLDSLVAIEIRNWITRELEASLQVLELLTSSSITGLGDLILKKSKLVNFQTAEPANSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLG5</accession>
    <name>A0A3D8QLG5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_10944</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLG5"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF149">
        <property type="entry name" value="TRANSPORTER, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="193"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="519"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="266"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="269"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW62642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="559" mass="62061" checksum="A1EA2F7651A7EF47" modified="2019-01-16" version="1">MDQNLDERAVHELEQELHTEIYPGTEIMIDVGSHHFVKGGSEVLVPQPSDDPHDPLNWSPMWKASAIFCATFTSFAQGLGPLALAPMFGDYIVAFDSNLPDVIQFTGIAILILGFSNFIWVPLQTCFGRRPVLIFSTLVCFGSSIWRARANTYGSFMGACVLNGIGAGPAETAQPTIVADVQFLHERGKYNTLYFAFYFGSLMVGPIISGPMAAHLGWRSFWWFNTGVLGLCVICNIFLFPETKYTRNFAPANSILQTPSPLKSASTEMVEHKGNNSSDGIDHEHGAPIQPTQTHGSAELQTIHTHQDPWLGRGRPSKAQFKLWQPYEGSIIRELVLPWYLLAFPIVEFAAFVVSWSASSFLTLNLTQSQAFAVPPYNFTSQTIGFFNFAILVGALIGLFTAGPLSDAIAARLTKRNHGVREPEMRLLAMVPYVVIMMIGNIVVALGYERGWDWKVIVIIGFTCAGIQVAALPAIASTYAIDSYKPVAGSMFVAITVNKNVWGYGFSKFITVWIERSGYIPPIMTNMSLITLWCLFGILFWFCGKTFRKWTRDSKVHRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QM05</accession>
    <name>A0A3D8QM05_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF7580 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_10796</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QM05"/>
    <dbReference type="OrthoDB" id="1911848at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF1">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7580" evidence="1">
        <location>
            <begin position="696"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW62494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="899" mass="100208" checksum="C10216D452C14AC2" modified="2019-01-16" version="1">MAFSACRVSLLPQSFQRAQVPELFSPLDRTLITHTSLAPGIDGTTQTATVTFQGAPEILSHLTGDVEFVELTIGCASDEGSQVDISVRVDVGFRGLTPLNTTPDDNAVVLVAVTGLAGRAFGSWQGRSGSMWLRDFLPQDVAHLRTLTYGYPSRLFRSLSTASLLDFTISFMEDLKAYLSISKARRLILVGHSMGCLIIKQALCECAARGFDELERAVLAVIFFGPPHRGLNNPKLQECVFGTPPETLVQDLRRGSSVLTNLNEAFSRICREMPIITCFEMLQTPTVTVDENGIWKRNGPPDMMVDRDSACLYIPNEKRIPIHANHSIIAKLGNDPGSEYHSLRDAIAVIVEEASGIRYQAFRLFHECRDMYKVLISAVEAGNQTQLVDRFKIELTRFELWGRLSKIIVLRSVSDANQSANYGLEDAARRICELVADLTDEGVLNQRFGIKFLSHSQRTASANNTGIMMSSPASATHTMFPLSEACLNSLGLQIHRLQALSCVSSDHQKALDLLNTIHRVHNLILSTLLHSGCQSFDQLFTAALLRMNSRVDFSGAEHSDGTIPSDVSRSATLKLLGLYLKSGIVQRLKPSSSRKVFPATLDLVGVPQSTSRFITMQNSTEMGLKKRVFIEWRYYDRKSEIAQSGDITVRIDNLMKILTCSPRPTSLRILDYSGYFHDFHHDRFGFVANLPLGIAESSQHSHRTLNSLLSDGSFKPSLTDRFQLARTLLRCVHQFHLLGWVHKGINSHNVIHFQMESDKVVLICDPVMTGFDLSREDSPVEISERNLGDDLDIYRYPDCRNGSPAKFRASFDIYALGLVLLEIGFWRPLDTLAKANSVTKSESATKVDRVLPSLIDQLNHRTGDRYYSVVQKCLQAPRFATEEIKTLEDGLIELDRCCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QMC9</accession>
    <name>A0A3D8QMC9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_11102</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QMC9"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW62800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="156" mass="17184" checksum="2206A39B0E7864D5" modified="2019-01-16" version="1">MQGSAVNSPKATDLQCFIVAKVQDASTAAKVQIIDVFWRDGRQGSMVRGRARVVTAFAKQWAKTSQEARPQTSVENPGQCRGTPPGPGSHYMTNLAQQVWLPWAPPHIQASSSYGWLWGKGPRGKPAVSQRGASRRKAQKKQVDALSRYRMTPLRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QPW2</accession>
    <name>A0A3D8QPW2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein S4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_10334</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW63832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QPW2"/>
    <dbReference type="OrthoDB" id="1109245at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000005">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.740:FF:000001">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_eS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032277">
        <property type="entry name" value="Ribosomal_eS4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_eS4_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="Ribosomal_eS4_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_eS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018199">
        <property type="entry name" value="Ribosomal_eS4_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003312">
        <property type="entry name" value="PRK04313.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16121">
        <property type="entry name" value="40S_S4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00528">
        <property type="entry name" value="RIBOSOMAL_S4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 9" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6 7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6 7" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="8">
        <location>
            <begin position="42"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR002116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW63832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="262" mass="29328" checksum="3D0E9A3727BBB544" modified="2019-01-16" version="1">MGRGPKKHQKRLSAPSHWLLDKLSGAYAPRPSAGPHKLRDCMPLIVFIRNRLKYALNARETKAIVMQRLIKVDGKVRTDATYPAGFMDVISIEKTGEHFRLVYDTKGRFTVHRIQAEEAEYKLGKVKRVQLGKGGIPFLVTHDARTIRYPDPSIKVNDTVKIELATGKISDFIKFDTGVIAMATGGRNMGRVGVITHRERHDGGFNIVHIKDAIDNSFATRESNVFVIGSEKPWISLPKGKGVKLTIAEERDRRRAHAIAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQL3</accession>
    <name>A0A3D8QQL3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoglycerate mutase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_10608</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQL3"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF24">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW64106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="245" mass="27424" checksum="5A861A63A22AB187" modified="2019-01-16" version="1">MAPTVILIRHAQALHNVAQDYTIHDPPLTELGFGPQCDELAQHLQTKLPLAHQIDLIVISPMRRTLQTAQQGLGWLIDRGVPVVLRPEWQENSAKPCDTGTAIVDMAKEWHQFDWSTVDPRYPAKTGLYEFSRDGLTRRGVECRKWLRDRPEKVIAVVSHAGFLRCGVSGRKYENADFRIFDFENGAEELGGKLVEWELTKSNGGGLGKSPKGFFPMTPEDYANVWPPAQDVKKAVGEPVKESPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QRB0</accession>
    <name>A0A3D8QRB0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prenylated rab acceptor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_10682</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QRB0"/>
    <dbReference type="OrthoDB" id="63113at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="289"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW64180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="46884" checksum="C68B1352E80BACFA" modified="2019-01-16" version="1">MPSWGRPPGARGSRRRRQWEYDQAYWQEQARVEELESDDTDTHGVGLNFKEKRFASDPLQFTGIDLASATRTRKKYAYDDTDTSDESSDSLGEDDDGAMQIVMRDKEEALVQSALARIRRAEEKGKREVRLNQDELDALAKRRKRMQSAATAKSKKKSSSGSGSDHRRKSERHVVSLPIASVEPISRKSKSRRSDDIQAAAPAPGMLIAGPDGPMYAPFGYNPAKSNSTRNSPSRPRSATNRELRGTPPPFPFPQGQAGRHFSDGTRPGSSASNSSRRPLPDDEDWVPSNSRRSSVSSQYADPFLYQTSSEQPPPIPPQFIQPTASGRRNNSGPAEVNYASVRRTPPIGGYASNSRGTHSDQSLSRRHEAEVPDSQGSSSSVSTEESSDDPLGNGVQVFVEEREPDRSKSVVSRKPVGGRKKGKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QTP9</accession>
    <name>A0A3D8QTP9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative NAD dependent epimerase dehydratase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_09895</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QTP9"/>
    <dbReference type="OrthoDB" id="408152at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040632">
        <property type="entry name" value="Sulfotransfer_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978:SF4">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOSIDE TRIPHOSPHATE HYDROLASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36978">
        <property type="entry name" value="P-LOOP CONTAINING NUCLEOTIDE TRIPHOSPHATE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17784">
        <property type="entry name" value="Sulfotransfer_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW65203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="178" mass="20188" checksum="63B5CE2A612F921A" modified="2019-01-16" version="1">MREVGKNQHPQYWIAALKAKFEGDGPAIDRAGFDEFLAGYAGVSDSPAAIFPDELIHAYPDAKVILTTREEDKWYESMMATIIHAFGSINKPGPMRSMAELYHKHLWDNDFVKNGRARFREHNEHVKAVAPTEQLLVYEVKEGWAPLCAFLGKEIPEKAFPRSDDWLSYKQAHSSGHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QTY4</accession>
    <name>A0A3D8QTY4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase C14 caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_09927</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QTY4"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW65235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="267" mass="29113" checksum="9D313684BFA2F822" modified="2019-01-16" version="1">MPRRKALLIGINYVGTKHQLSGCVNDALNIRKYLIEGRGFSGDRHDMVMMTDTPENRGTPFEPTGANMMAAFQWLVTGNRPGDSVFLSYSAQVRDPDGDRESGFDDTICPLDFESHGQIDSDTLHKTLISPMIPSARLTILFDCCHSGSAVELPYVYRPDAAGNVNLIDNVKQGINLASAAMNLLQGGFTSKKVEDAKVLFGGAQSFFKSLHHRPGRPVNEDGLDEEVFVEDWKNEGKDVWMFSGCADNQTSADTSIAGAPTGLIPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QU80</accession>
    <name>A0A3D8QU80_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vps72/YL1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_09933</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS72/YL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QU80"/>
    <dbReference type="OrthoDB" id="3942062at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046757">
        <property type="entry name" value="YL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275">
        <property type="entry name" value="YL-1 PROTEIN TRANSCRIPTION FACTOR-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05764">
        <property type="entry name" value="YL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="3">
        <location>
            <begin position="539"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="208"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="287"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="603"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="88"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="330"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="378"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="410"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="603"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW65241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="648" mass="70529" checksum="092F36691DEB2CA5" modified="2019-01-16" version="1">MTADDADTPMTTEDHEDVDSSSASGSEEEQVEWLATTREKRSTAGNRLNSLLQAEEPDDELELLFAEDDEDAGFEDDEGAQSDVQMDSSDDDEDQGPAAGADDDEGERELQRQAKAEKAAAKKRRVNDGIPKVFKKKVKIDPTASQALPPRPKKKSERASWLPTAEDAPTRASARGTTKKSKEQLHEQMKDRERRRLKQLANMEKAAARKEAMRKPAMTQEDRLREAARVEKQNSKSLSRWEEAEQLREEEQRAKLAALSNRKLEGPVITWWSGLGQYVGGKLKQVGKVLTLEDPKEKPSTKKRKASEMEAAADVPVSVQPTPASQPPEGEEKPSDAIQKSDETTTKSEIPSPTEEKETPKAETPASTSPLPSMTAPAPIPHPMPAPMSTPIAQPLRAPSPLAPPQSFLAPPPFSLAPPNGPAPSPLLAPPPFFNPPLPRPPPPLPAPPVQSPAIPKASTPVQNPAIPKAAAPQGPPPQNPFTFTPVPAPPPPPPVHEKTVRNYLILSNFDETAIKDKNVQTQILFNRKFTKAQKISQTPCAITGYPAKFRDPATGLAYCNAYAYKEIQKLRKGTYKWSDLLGVYVGQGTFAARGVPGRFLKGGEKEKDKEKEAVVVQGKEVKSEGLDGGGEKEKENAQEKSSAAVPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QV22</accession>
    <name>A0A3D8QV22_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_10317</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QV22"/>
    <dbReference type="OrthoDB" id="2328572at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045122">
        <property type="term" value="P:aflatoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013700">
        <property type="entry name" value="AflR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050675">
        <property type="entry name" value="OAF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069:SF31">
        <property type="entry name" value="MONODICTYPHENONE CLUSTER TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31069">
        <property type="entry name" value="OLEATE-ACTIVATED TRANSCRIPTION FACTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08493">
        <property type="entry name" value="AflR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00755">
        <property type="entry name" value="AFLATOXINBRP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="25"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="330"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="330"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="351"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW65625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="459" mass="49751" checksum="3382EAD7012D9AB5" modified="2019-01-16" version="1">MTASPGLVAAPLSSSEPEVQKLRSSCEGCGNAKVKCDRGHPECRRCVTLGQSCVYGISRNFGKPPRKRVSAHLDIANNLSNRKRVKGTTGTCEIRRKGVEQSQVANQPAQHTQSSHSSFDTTKCIENCEGRTKALSPREPQCAIEAAQLSISDTMTGGLPIASSNNPTLSIFEQNPLSTSFTAPLLFNEWSEFDIWGPALEFPSVSKSSGPENRLSVSALHSISNPSTSIDSAESHSCPRGSYELFRDLICPSPFLHAPEANSDTVSAQFDEVLHFNRDAICRLSRLLKCPCARSGHRAMVHASIVSRILIWYQQAAGWTGSGSWETRESSFAASSLPDSESSSSPPDPGTTANTEPSSPLTLTQCTGFAVAQVPVSMGTFSIEDQNMQTAFRNQLILSELKKIASLIDNFICQGPLESPVTGVTSLYSHLGTWLRNELLKTMTVLKARLRELNKSLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QY40</accession>
    <name>A0A3D8QY40_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RhoGEF protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_09471</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00160">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.900.10">
        <property type="entry name" value="Dbl homology (DH) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035899">
        <property type="entry name" value="DBL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000219">
        <property type="entry name" value="DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041675">
        <property type="entry name" value="PH_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057283">
        <property type="entry name" value="RGF3_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052233">
        <property type="entry name" value="Rho-type_GEFs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572">
        <property type="entry name" value="RHO1 GDP-GTP EXCHANGE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46572:SF1">
        <property type="entry name" value="RHO1 GUANINE NUCLEOTIDE EXCHANGE FACTOR TUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00780">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15405">
        <property type="entry name" value="PH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00621">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23582">
        <property type="entry name" value="WHD_RGF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00036">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00325">
        <property type="entry name" value="RhoGEF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48065">
        <property type="entry name" value="DBL homology domain (DH-domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50010">
        <property type="entry name" value="DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DH" evidence="5">
        <location>
            <begin position="946"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="domain" description="PH" evidence="4">
        <location>
            <begin position="1174"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="1419"/>
            <end position="1724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="458"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="518"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="579"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="692"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1260"/>
            <end position="1297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="213"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="244"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="292"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="611"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="702"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="724"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="738"/>
            <end position="747"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW66722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1762" mass="193933" checksum="22C400A05AF50C0A" modified="2019-01-16" version="1">MSFNQNGSQRRYGHVPPAQYGPPGSQDLNSNMQRRPSFNNGDDAALSHGQGFPGRTTSLHEERYMTSPNTTSPRSPTHSTFGNNTQTFPVLSGYQHQYQPEDQHSPPLAQQSYNPQAFARAQSQSSQYRPQPTPSYGSTPGYAGHQPYNPAAYSPVASPQRQTTSAGYGSYTPSYSTSSLPQPPQSPTYWPGTQGPPVPPRPTSSHHGPQYASRPTSQAEYNQPYNPSYVPSHSGSLSSRHAEYYQPPSSSSYSNGYGLDDNTTPTSSQAPYPSDDAFTAIPAPSYADEENSFANRTKRFSTGSHHSGGAITSPGLPQGSPGATGLQRHPTLRPLPRAPVGDETDDEDWGFGAHGKTEEEIAQEKLFADIDSAVNVGSSRSRHGSEQNGDLLDGELRRYNSTRTTLNPTDPEHSMAAITSYETIYDDYDDANESDVEAAAGLEAMRLAEEQEAQLGSGGLTFGTYESHPAQLSSKPLPPQPQDESSDSDYKNMDLGLAGGGYDAHMSYGAHVGGLATGNSSEMEDQSRPLPTPGEIGRSDIHQHQPTPGLGGMTDYSIPGETTLHPFPAFEDARVDTFGTGGLQRPTSQSHRLSFDEGDEQVSLHSRNDSRLSNLSGSESPTRDDMPELFYHPGMSSSPYNRPLPAVPPLSSDTIPQLMPAGSYMHNYSGSFSTGERPAYLNNGSGDYSPQTMLSPGGAYVPVPRSTSLSSHSSTPVTVPPVRSKTDAEERQARAKAARGGVRSASGLDGFDATTPQTAMSLDLPSLPAGRRKKFSPSRLSSADFKKCQEPWALSGIATWIREMAGGDTGEGEADLRTKTIEDGLVALFTHKVPTMNTADAEILSSRIVNSMLDGGLLVPEEEWVKFGQGEISGVLWQLTGSGCYAPKLHEQEIPGRCYSHHCTRTLKKINLHSQTLEPSKKSEDWVTFFKLTKEQLEGAHKKEIERQNNLHEIVMSEDLYMDHLNVLRIIYRDELAAWNPPIIDKKKISKFLASVFGKVEAIKEVNENYLLAQLKYRQKEQGPWVVGFSDIFREWIRKARAAYIEYAAGFPYATYLVRREAEKNLLFRQFLDQARENKMSNRLDWNTYLKAPITRLQRYTLLLGTVLKNMTQDTEEKVLLATAIEEIKAVTLECDAKVDEQAKKVEMIELQSKLFLRPGMERVELNLDHLGRELIFKGDLQRAGTNRFTWLDTHAILFDHYLVLAKTVVQRDASGVRKKEVYDVSKLPIPMQLLVLESTNDDPVVKSSVKGIGAVTSVAKPTTGSSADARLMRPTTNGERPGPLEHTNTGSSASSMSMVSVTRISTNPTGEADKSMYPFRVKHLGKADIYTLYAPSAQNRQDWCEKILEAKTRHAASLFAQNAEPFRLRVMADTAFGNNEGFPSRSTVVSVKGTPLDRSIRDIERVFGSGPRPGPVCRAMVNCATAFNSYGKSMVAIGTDYGVYTAEAGDTRGWTKAIQISRVTQIAVLEEFSLCLIIADKSLIAYHLDVIVPVSSFPAPQHDSARKAPQKLSGNRDVSFFSTARMKDRTLVFYKKREGLHSTFKVLEPVFQKSTEKKTRLFGKKFGGNTEFFREFDEFYIPTECFTINLFHTYIAISTLKGFELMTLDKKTPISIPDTKNPAIGSIAARLQGQKPLGMFRLSDAEFLLCYEECGVYVDKHGEISRGVVMEFVGKAKTAAMYGAYLVLFDSDFVEVRNAENGRLRQVVAGREVRCLDYGINPQGGGGQVDTSRTLKLAMAHPEIPSNQIVLELVLNDGHTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QY50</accession>
    <name>A0A3D8QY50_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_09369</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QY50"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF12">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW66620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="32961" checksum="4724FFDB4013C283" modified="2019-01-16" version="1">MVLTFAGTTWNWNDGRTIATFVMFGLLLAFFVVQQRLAIFTTRENRMFPPGRLFRSRSQILLNIEMFLASWAVFVPLYYIPNYFQFVHGDTAIMAAVRLLPFVTILIVTNIVAGVLLPRISYYAALYFAAGILVTVGSCLMFTITIDSPPAHIYGFSVLIALGVGLIFNAGYSIAGIKMGAKGGSTDDINAVVAVQNMSQIGGVLTALLVAGQVFQSIAFRKLTVLLRDQGFTDAQVRSVAAGSTSLVFESLSPSLARKAVEAVTSTISTIYVLTIVSGGLSLLCSLLLKRERLFKPTTVSPSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QY96</accession>
    <name>A0A3D8QY96_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glucosamine 6-phosphate N-acetyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_09508</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 8">
            <text>D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10292"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="2.3.1.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="8">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the acetyltransferase family. GNA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.4" evidence="8"/>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QY96"/>
    <dbReference type="OrthoDB" id="10039976at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00529"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004343">
        <property type="term" value="F:glucosamine 6-phosphate N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000048">
        <property type="entry name" value="Glucosamine 6-phosphate N-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039143">
        <property type="entry name" value="GNPNAT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13355:SF11">
        <property type="entry name" value="GLUCOSAMINE 6-PHOSPHATE N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="9">
        <location>
            <begin position="27"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW66759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="179" mass="19918" checksum="2E29084A6D43BA8B" modified="2019-01-16" version="1">MAATASTSLFDASLISPEVASSLPDGYQVRPLERGDYAKGFFECLQVLTSTGDISSQQFNERFDWMSTQGKGTYFFLVIEAEGRIVGTGALIVERKFIHNLGTVGHIEEISIQKDQQGKKLGLKMIHAIDSVAANTGCYKTILNCGERNEGFYLKCGYRKQALEMAKYFEEEKNGYERG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYL7</accession>
    <name>A0A3D8QYL7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_09520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYL7"/>
    <dbReference type="OrthoDB" id="10379460at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017762091" evidence="2">
        <location>
            <begin position="18"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW66771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="202" mass="23548" checksum="A1DEBA2349319937" modified="2019-01-16" version="1">MKLALLGIAILISSALAFSIERLKELNKAVPKPRYKHDCAHRMPLEYHCHRKPIPTEWTKEARPKLGYSPRTGGPLVTPTPNPPVSKGGHRKRRLHERALATREPAYPGSDERGVTSYFRRRDQHDNADARDWKKFWRWLINGNEYTPLEDPLKRPVRDTVYWLPPGLDYDYHPYSDDPDTPVDLKNGKMWGNPQPEYWMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYX5</accession>
    <name>A0A3D8QYX5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_09782</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW67033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYX5"/>
    <dbReference type="OrthoDB" id="5030973at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW67033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="288" mass="31863" checksum="221261473EF4B036" modified="2019-01-16" version="1">MATETAPDDDLPSFDIDMFPIGDDSAFRTQNDPSAPYQRSDVIKRKGAVDIRCNCVDIVHGKFDSSAYATLLVLQFRFDPRKRARRIASAHITLAFSGTTPDKPRPEVYAISLDGSFHMAQTSEHQEVVKGGEARLGTSIIPGVSVDGGFKWEKMTSACVTDTTRVVGSIDRIGYNYGPDNCVSWDLLENETRKTGVPALMRAGVLLKRKNNDTFKCTVKIKAEADFRSNLETIFGSTPKVDPILFDPTMPPTNRLMKYNTENMEDLDLGSVSDVTFMNVLDGTMKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QZ04</accession>
    <name>A0A3D8QZ04_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6546 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QZ04"/>
    <dbReference type="OrthoDB" id="4802432at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046676">
        <property type="entry name" value="DUF6546"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20183">
        <property type="entry name" value="DUF6546"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6546" evidence="1">
        <location>
            <begin position="145"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW66910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="363" mass="41143" checksum="B73377AEC2E16110" modified="2019-01-16" version="1">MCGRDQHAEQSMLVKASSDHHHGWIAGSQNSIPTSVAIDKVFDEIMGEGPFDNEEQEGQWWQQLPLVSAVTGVLLRQQNRRRWKPAALAHMFARRLDSRKLITSLGGNGAIFSSSGRTNVSATASVYRSPPLLSLRLLFESLSSDRLRRLVVFENFDQMYPASYMNLGCVPMRIPSSYVSRAVANVSLTLEHLSASFIVDARDFFDARELSWKWPNLTWLALTSRLLVPQERSTELDDMLRAAAVAAMKMPNLETMEIWNGENGLAMLFRYQRAERGRPAVITWRGTWELTLRPAVIQAWRSVALRHRGQGHIIVKELLDASICVKSHGDAIRHLKLSRPVIRPVSLRQIRMEHIIREGVQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QZ76</accession>
    <name>A0A3D8QZ76_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF7779 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_09804</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW67055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QZ76"/>
    <dbReference type="OrthoDB" id="6161812at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056681">
        <property type="entry name" value="DUF7779"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641:SF19">
        <property type="entry name" value="NEPHROCYSTIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45641">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN (AFU_ORTHOLOGUE AFUA_6G03870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25000">
        <property type="entry name" value="DUF7779"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13424">
        <property type="entry name" value="TPR_12"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="DUF7779" evidence="4">
        <location>
            <begin position="549"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="780"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW67055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1003" mass="113698" checksum="D8F115156B15749C" modified="2019-01-16" version="1">MQDQVSPTSSSADSTEIWSSWDRRPAECTPEGSSTPPLSNIEKHWEAIWMDALSVCKKTLCEEDYAVVFQFNSCEALMENLQVMHETYTRESFPSILRKLKPLLDPTLKRVTHAIALCMRSHHIRTGIIWGLVNLLLDAASAFDTALSQIIEMIETIIRGLEIIHIYLPSHSVSIEDQNCLVVLFVDVISFWSLAVTQLRRESIESLLLEAWSRFAETDLAKISTKIKNNIQHLKEKSQALAIRQSGQDRSQTSIINDVVRLAREENSVHPSERNLAQPSGKLPCHYISLDEYPNLFPRDDISRKIREDLDPKPTNIALQSCLLCGIGGAGKTQLALAYAYEWKSRGMQATFWLNCETPLELSQSFTEIAVALNLEGAASVGKNDANKFLVIQWLKTTDVHWLMVFDNVEDFNLLRDNWPVSSCGSILVTSRHDNSDVTDLIPKQIPVAELGLEEGARFLLDLVYLDNTLTDSERKSESQFAADLLSEIGGLPLTLTTTARQVRRRSTSVEKFLPLYQTNASRVHMEGRVLSHKPFYKHSVSTVWDMPFKSLDDNATVLIGVASVLAPVDIPIALFQPNSFTDLPPCLEFCGDMWKFDIALTDLLKNSLIGRDSRTGLMSVHRTIQMEFRQRMNQVELLDFFDTAARLLLASFPKLVNGVSLRTRWPVCNQYINHVLTLSKRIQEHGLTDPTQTKFENFVECASSAVWYLLETGEWVVCLELLNIALRLCKKDSLIHANLLNTKGGVENKRNHSKEAYAAFFESRRIRETLLPKDHEEIANTYNNLGNVYQSDCKYEEALDLHQKALAIDMTKAVEEQNKIVHIRYLNIGNTYAFQGKCSEAREYIEKGRRHAIEMFGAQTHYDAVADWSLARIDYAEGNYRVAREKYQRAFEIQEKGNPMSPLTSAAAYKLACVAIREGKLEEASNLLQRTLLIAQFNEARKGDKGEIARVIRKLATIYYLRGDNGNGDTLLAKAEVVRKKLQPELLNEENSYDLLVSSFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QZC8</accession>
    <name>A0A3D8QZC8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Methyltransferase type 11 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_09673</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QZC8"/>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF80">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="4">
        <location>
            <begin position="66"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW66924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="220" mass="25610" checksum="F5808090EC3571E1" modified="2019-01-16" version="1">MAMSERELKELADPKYWDERYIKEREKNGEDSEATLESFEWFRDFQKLRPFFETNLPSPQSECHILHLGCGNSTLTADLHALGYTNQTSVDFSHVVIDAMKIKYSDLDTRWKFMDVRDLQLPDASVDVAIDKGTLDAMIHGSLWDPPEDVRENVGKYVQEVGRVLKPGGVWLYITYRQPHFMKIHLEQEALWNLEVRVLEDPDGAGGFEYFSFVMQKRID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R314</accession>
    <name>A0A3D8R314_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ypt of gyp1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_08997</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R314"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.80:FF:000055">
        <property type="entry name" value="TBC domain-containing protein C1778.09"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000023">
        <property type="entry name" value="TBC domain-containing protein C1778.09"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="485"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="16"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="234"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW68340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="757" mass="84941" checksum="6749AE01D47A86AB" modified="2019-01-16" version="1">MAVGPALDEHGIFSIPYEETLPARPPIPVTVALPREPPEEQHPALRRPLTIDEKKDETKRDSGLAPTTSTAALDGSTNTTEEGSSLSINSDSNAKKTQPRPSTSMQSPPQTPKMVKSESWGSGSMSMFKRPMSRRAETPKSPVSSIQDFSPILTPIPTENLMDNEFLSQMSFSKRGSMMLGGKKAVNSQARLNGGRRQPSCSMLASSSLRVLPDELEKESQKVRSMYETSASYDWHAGKFSTSGDQPKDSSETTSLEAPSISTGLLSPPLESHPRAESRMSSRDTLARNEHELAGGIEDWEDVNGGDVDRYGFIDRQRKSTPGEEFQEPRPPQRVSTVLQMASETPRKKRAFGRSPSTATSRTGFRRAPSRKVSARSLNTFVSSSSKRSISRQHLRAAANRLPGNRDRRWMDEAGDMLTLPPGLADIAEENEGGKAVEEMKKKEWERTEKWRRMAKVVKNGKDGEGMEFEFNTRSPKLIARTWKGIPDRWRSAAWHSFLSTSARKRPDSATDEEIIQAFFRLQDQSSADDVQIDIDVPRTINSHIMFRRRYRGGQRLLFRVLHALSLYFPVTGYVQGMASLAATLLCYYDEERCFVMLVRMWQLRGLDKLYESGFAGLMAALDEFQKSWLHGNDVSQKLDELCIEPTAYGTRWYLTLFNYSIPFPAQLRVWDVFMLLGDSDVSVATSPERPFAGGLDILHAVSAALIDGTREILLDSDFENAMKVLTSWIPVKDEELLMKVTKAELKLHRRRKQSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R3E7</accession>
    <name>A0A3D8R3E7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_09135</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R3E7"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW68478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="129" mass="14573" checksum="0D2BBA96714975A0" modified="2019-01-16" version="1">MHNLHKDVFYVPDPSLAFIEGPHHVATFYLSEYQAIAIAAVYSGKSALPSQPEMRNEYNKKVKEKEVGRAFHSLKGVEIKYTNELISWINPRIVASKGRAVDAHLEAWKAQYEVLRQAITALGPQAKRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R3K1</accession>
    <name>A0A3D8R3K1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R3K1"/>
    <dbReference type="OrthoDB" id="5945798at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF298">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE ATXR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW68633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="329" mass="37648" checksum="1AA855B5808E827C" modified="2019-01-16" version="1">MSIHQPHQNTIGTALDLVGSLINHSCDPNAFIFFEQSQLRVRSLRPITAGEEIAQTYVDSRLGVMMRQKILKSDYFFTCECEYRTDFSFTWLSKEKFLGGSRCQEELRDCQAWASKENISVHVFADTENEILQCLNRVIKDRNTSGTRKALEQIEADFSLLTTRVFPKQDWPDTLWPMNDVKLLLAKLYKDNENHQQAVIYALKGCLGFTRRSGPEWDDTLFELLQFIALLVIPERKGISAKPSSFPGDQQLWDFFHGLLHQLLLQSEKTFGLDTAYTKAIITWHANAERSAGRPLPGETGFSKRFDKAQSVILSWAEIDMSRKIVLTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R3L4</accession>
    <name>A0A3D8R3L4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7029 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_09274</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R3L4"/>
    <dbReference type="OrthoDB" id="160645at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054293">
        <property type="entry name" value="DUF7029"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22974">
        <property type="entry name" value="DUF7029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017610325" description="DUF7029 domain-containing protein" evidence="2">
        <location>
            <begin position="17"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7029" evidence="3">
        <location>
            <begin position="95"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="708"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="708"/>
            <end position="764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW68617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="984" mass="102855" checksum="5497307D086E5316" modified="2019-01-16" version="1">MVVVLAWAAMLSLAAASALIPTRQDQPKVVVYHDCAAAPAPPPTQQIIETTTILVPSVHSSVDVNNLNNLKPATSSSFYFANGESAQNYALVNAVTNHPTVVLQHTSYITNVQCGPSQINITFSNPDAFSLVQGSWNGTYIIATSSGSCQSSGNTNNLGFFLVTNTNFVEGILSVILDAVKISVEAALSNFDVNFGVSPTATSAAPTETATATDSLTPLPTPVADGNSTCGDPPAATISGFPTAPCGALFDATLDQEIGFFLFDESDFSASLSSAAPGLGDYNFADYDDDLDNDISSLQKRQRGKVTKPTVNKTPVVKEDKVQQETAARQKKKEKDDADKLKAAKAAEVMKAKAKADQEAADALAKSKAATAKAEQDRLAKVAADAKAKSDKTNAKNVAAISPDAAAKLASTLNTAVAVIKIATTETVLDQVLLFDLPPKSAQYSSGDSPFGSAIPIFKGDSSATGAGSLYCVGCAASGKLSFSGKLSFNLAGGVAAPFKAAYINISGGLTANFGLGLQSEGKLVKQGNLDLGKKPGTKYTAAGIFDFVPEVAISAVYDVDVEAPGTLFGSASLNIPDFNTYLDLADRSKTTVGTITPAFTTNFTADGQIVAKNVSLSLPMRIGMRLEILEGRVPIPPTDIFLVNKPYLIASAQYVPGSSTPSSCNNGINYKAEFFDETSYILLGKPNDINKFSAASIGPTCKLLGGSSTSSASSTSATTTSATSTSADTTSATTTTTSTGSTTSASTTSMSTSTTSTSTSTATPGAKRSLPQREVLDAKISERQETDDTDPPDSVYVDDSASLAAAIDEPYNASDPTLLYFSPIYDSTQEFSLLIDDSGNFGVQLANASSPIEFGGYENITVTDSAGRFMFYYPAVMDTYGVSRFRMNFFENIPVSADLVTLVPINDDDSLSTPGAYSAIDTQDNIFFTVICLYEDSTSKIFLVDDIVDGLVTLTDPALRFIVTGGVVTDCYPIEFISPGPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R3P4</accession>
    <name>A0A3D8R3P4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Muscle-derived protein (Neurite-outgrowth-promoting)</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_09091</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the taxilin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R3P4"/>
    <dbReference type="OrthoDB" id="425555at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026183">
        <property type="entry name" value="Taxilin_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16127:SF13">
        <property type="entry name" value="GH01188P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16127">
        <property type="entry name" value="TAXILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09728">
        <property type="entry name" value="Taxilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="134"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="392"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="414"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="456"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW68434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="55194" checksum="2751A0E3A29FF251" modified="2019-01-16" version="1">MSTTVNHTSAPASSRPPALSANHSHSDPAYTNGEHHHHHHSGPSYPPGANTSKKSKQKKTADPQETSRQLAAKIAQLESANLKEDEEAQEVERDVKVCKRELNATISKMDEVAKIEHLNSKAIEFYREMKRTSLSYQKEKKQRDQLQKEKDRNGSELSKSVTLREKLEKLCRELQRENNRLKSENKTFADNEKENQLTWDEKYQQLLWTLQDYQEAKDHPQAQVVPVEVEDLFKQRFKSLIDQYELRELHFHSLMRTKELEVQYNMARYEKERKAAEAEIAKSRSLNTQVMTFSKTESELRNQLNIYVEKFKQVEDTLNNSNDLFLTFRKEMEEMSKKTKRLEKENLTLTRKHDLTNRNILEMAEERTKNNQERDALIKKNEKLTNIINQMQKQGRGLHASMTGGGSSSMEGEYAGEGDLEGTESEYEYEDEDGEEEGSEGEYDEDTEEELHPEAPKPFGPVPPPPTNGVPTANGINH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7X3</accession>
    <name>A0A3D8R7X3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 5">Tyrosinase copper-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_08405</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7X3"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1280.10">
        <property type="entry name" value="Di-copper center containing domain from catechol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008922">
        <property type="entry name" value="Di-copper_centre_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050316">
        <property type="entry name" value="Tyrosinase/Hemocyanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002227">
        <property type="entry name" value="Tyrosinase_Cu-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474">
        <property type="entry name" value="TYROSINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11474:SF126">
        <property type="entry name" value="TYROSINASE-LIKE PROTEIN TYR-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00264">
        <property type="entry name" value="Tyrosinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00092">
        <property type="entry name" value="TYROSINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48056">
        <property type="entry name" value="Di-copper centre-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00497">
        <property type="entry name" value="TYROSINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00498">
        <property type="entry name" value="TYROSINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0186">Copper</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017567823" description="Tyrosinase copper-binding domain-containing protein" evidence="3">
        <location>
            <begin position="16"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="4">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosinase copper-binding" evidence="5">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW70008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="341" mass="38249" checksum="549BFE01230F5F7B" modified="2019-01-16" version="1">MLTLSLLGLAAFASASPLLTRNNTLAPGHYLAENITSQTFFNNSCTADTVTIRKEWRSLTDAEKKAFISAEQCLISSPAKTSLQGATTRFDDFQAAHQQGTNTSYGDIIHYTGQFLAWHRWMVHVHELALINECNYTGTIPWWDEALDAASGDFFQSDMWEDQYFGGNGSYVDSDGNNCVTTGSFANRTEHIGPLEETTDYCFARNFNQTKGLIWGARSQTDACYEYSDFTDFYSCMAYAPHIAGHQATGGIMTDVDSSPGDPVFYLHHNYLDRLYWQWQQINPTERLHLVGGNTTVTEPPSGWETMTLEYEMSMFGIADNVTIATVSNIQGGYLCYEFEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7Y5</accession>
    <name>A0A3D8R7Y5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I and III subunit RPAC2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_08559</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7Y5"/>
    <dbReference type="OrthoDB" id="510325at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055029">
        <property type="term" value="C:nuclear DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07029">
        <property type="entry name" value="RNAP_I_III_AC19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerases I and III subunit RPAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033898">
        <property type="entry name" value="RNAP_AC19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF28">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="8">
        <location>
            <begin position="69"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW70162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="162" mass="17640" checksum="F5EF292F55B3C610" modified="2019-01-16" version="1">MAPAKTKKSAKVVASQEEDITMDDAPVAPQEHEDEEGEEVAGEDQAPPEDEDTLEQRITVLPGGTEQAASFQLKEEDHTLGNALRYIIMKNPDVEFCGYSIPHPSEALMNIRIQTYDGTAKDALSKGLDDLMDLCDVVAGKFQIARDGYMNSEAGKADQPEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R804</accession>
    <name>A0A3D8R804_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_08458</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R804"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017494090" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="17"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="48"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW70061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="598" mass="63929" checksum="1FCDF2083CBFA3DF" modified="2019-01-16" version="1">MFSLPLLLALAAVGYTAPTHNATSTALPVVDLGYTLHQATLNATGPYPLLNFSNIRYGAPPTGDLRFAAPIAPTKINRTVNDGQQGVICPQATPTWVITALRYVEGLPAATSTAKASSSAALASLNVSALSGPAADISEDCLFLDVILPEKIYNSPFAVAQRGNSAIEEDACGGDESENGSGAPVLVWLYGGGYVTGNKKSTDNPSTLLARSVEADGEGVIYVAPNYRLGMFGWQASPAFQSQNGTANAGLLDQRLALQWIQKNIHLFGGDKNRVTVIGESAGAGSIAHHIAAPASYSTSSLFKQAIAQSPAYQPIVHAQETKTWLETLKIASEISNKTISTLAELRALPFLTLYYTNVILVAQSAYGTFTFGPVIDGSYVPDLPGRRFLAGKYDKQVSIIAARNQNEGRFFTEPTFLNATNTTSFDELVKMDVPTASAASLKHIIETLYPPIFNGSLPYMNEFERAALLTQEFTITCHSYELASAAAAGNSSAAGRWKYQFSVPPALHGDDIEYTFFNGDTSSQDIGGGTVVSKVAGVLQDIIVDMTEKGTPNFQQYGTGAGMVFDLNVTRLGSVMSDFDNNERCKYWQTAPWLTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8C5</accession>
    <name>A0A3D8R8C5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rap-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_08689</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="19311at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033596">
        <property type="term" value="C:TSC1-TSC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032007">
        <property type="term" value="P:negative regulation of TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051056">
        <property type="term" value="P:regulation of small GTPase mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11210:FF:000007">
        <property type="entry name" value="Tuberous sclerosis 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11210">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035974">
        <property type="entry name" value="Rap/Ran-GAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000331">
        <property type="entry name" value="Rap/Ran_GAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018515">
        <property type="entry name" value="Tuberin-type_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027107">
        <property type="entry name" value="Tuberin/Ral-act_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024584">
        <property type="entry name" value="Tuberin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10063:SF0">
        <property type="entry name" value="TUBERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11864">
        <property type="entry name" value="DUF3384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02145">
        <property type="entry name" value="Rap_GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03542">
        <property type="entry name" value="Tuberin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111347">
        <property type="entry name" value="Rap/Ran-GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50085">
        <property type="entry name" value="RAPGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rap-GAP" evidence="3">
        <location>
            <begin position="1284"/>
            <end position="1519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="643"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="765"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1059"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1518"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1554"/>
            <end position="1596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="649"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="665"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="784"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1064"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1522"/>
            <end position="1541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1554"/>
            <end position="1573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW70292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1596" mass="177222" checksum="238489B7BBB19B17" modified="2019-01-16" version="1">MSPAPADVAQTPEPKTTSSLASVFKSLTGTRSSKNAISQTPTPPPNAQLEQQLHPSAGKNAIYGGPSNYKQLYEQLKGGDTLAERAAAASSLCHVVAEYPLSGVMNIWFTAKNLIDSNNPPEVRVAGFELLTACVKHSSSSDLERKEFFDTLTAPANPDDFHLQLASVVALAKNGRDLSGFQYEIIPLLNSWLRDSFKMTTSARKQAGRQHRSQKAKAPLSEESNLALLFAFIVDVIKFSFNISTEETTNELIDVVLHICVSTPLSSDLKACIGVLDAIVTYGAIPSQKLLEFVKVLCSIHCLVEDVQPEAWRSISNLCKSHDGQTTVRYLLNILRQPNLDAANEKQTIREIRGALSVLEKLFAKDGESGYPLVPFTLLMDGLYRVTAVEHAKIETDILRMILSLFNNEKNEVMENVMEEDWALMFQVATKCAQRALETSDGRPLVDRSRMSSPLAGNSMVREEVIGQNVATSMAQTLYSLIIRIEQLLIKNSATEFLQRDECISFFISVHPHLPESCAKMVIDYYNELRLCYPSDSDWKNNARLILDAFFAARNQPTHIRLHALKAVTDVFDIVEMMDQGEEPESVETFVTSILDDVGDEKDIAVLQEVVTFAVAVATSVDTPLFSYVVDALCGTITSDRLQSPISPPGSRSSFLSSSRPTSPATSNSVVHTPSPSNVVTKGLIQIFMKTMDKTPAKTLRVYRELLSIVRSNSCETDARISALKMLCRLRADWAYRIFLTPFTESDGLASSLYRTQASLARKQAVDEASQQTRSSRADEASITRGSRSVSFGQGHPQTRQPVRASSGVHRALQRNHQMWMSPDPDALPETVSDKSSAMLTSVGDYEDPAVSSIEGRMALDLGEYLETIHTLLQNGCDWEVYSYVLVHLASQLTNQALFRAAIPQIKNLRVLVCEQLKNASFHEPPISSGLRKVDVGICLYQILTMVMGYHQEFSPQEEDDIVRTFVQGVGTERASKCCIHALSICCHELPRSTSKALASILQRMSQIITQSYVAVHILEFLAGLSKVQNLYSNFRDDEYRTVFGICFRYLQYVRDHPAKDSSNRNSQPYTRNSPATPDSVRDNSKAESNFQPNTSDDLPQYVSALAYHVITFWFLSLKLSDRAGHVSWITKNLISTDLNGKENMDEQSQITLDFMQRVAFADVDESAPDPNFTKELFGEILKKRWVIGNSIVTIEQSTRGEWAQITKRQPSGTSCYIIRERFARPPIHQSLVLTEATRIAPDVEANVVLPNHMLLQLSSSIPQGDGFTRPIALPDDDMMRRAISAFDRNSTVDGHKVGVIYIGEGQTNEVDILANVIGSSDYTELLTGLGTLTKLKGAKFNTQGLDREYDTDGEYTFCWRDRVTEIVFHVTTQMPTNLAHDPQCIGKKRHIGNDFVNIIFNNSGLPFQFDTFPSEFNYVNIVITPESRATFVATRFRSESHAQTAFYKVQVMSKPGFPEISPAAETKILSLAALPGFIRLLALNASVFSLVWANREGGEHISPWRNRLRQITRLREKYGTKQANPSPPGTSSTSANMRDSLNSLGRRSSVATFLTSTSEQNSQRTSVLSTAETEVAHPGTGEGSMAESMDFSKWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8F2</accession>
    <name>A0A3D8R8F2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-xylosidase C-terminal Concanavalin A-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_08724</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8F2"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18617">
        <property type="entry name" value="GH43_XynB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF12">
        <property type="entry name" value="BETA-XYLOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="7">
        <location>
            <begin position="352"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="18"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="5">
        <location>
            <position position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW70327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="523" mass="58386" checksum="086E02816F5B5D6F" modified="2019-01-16" version="1">MSSACEYKNPIIPGFAPDPSVAFVNGTFYLVNSSFHIFPGLPIYASQDLKDWTHIGNAINRPEQIDLSKSSIDSFGIAPGITLIAAEGHLAPSIRYHKGTFYVVCTNSVSDGTNLTTQNFYVTTKDIMSDVWSDPIFFEFKGIDPSLFFDDDDRAYAHGSYRPGPVCDPQCAIRQVELDIATGKALSETKEIWKGYLGKNDAEGPHIYKKDGWYYLLTAEGGTFEEHQVDMARSRDIWGPYNSCPSNPILTAYGTDEYVQHTGHGDLFQDGLGKWWITCLGVRKENGRFPLGRETFLAPVEWVTDGWPVIEHPRMSFQRHVLLASPDQQLPHESSPRVEDVYIRDANLADYTFSKDNKTVTLLARSTDLFAPTRSTTFVGKRQRGLDCTVATSLQWDSTSSTTGLSEAGLTVYKEDFRHISIYYDYALSKICFRRFHKFHGGATIMEFEVEPASISKIDFRIQASAMEYKFSFRVGTEWADAGSADTSEMTGIDFTGTIFGVFASSREGKEGGLVVMSCVDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8H0</accession>
    <name>A0A3D8R8H0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Post-GPI attachment to proteins factor 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_08742</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in the lipid remodeling steps of GPI-anchor maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum membrane</location>
            <topology evidence="7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the PGAP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8H0"/>
    <dbReference type="OrthoDB" id="419770at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007217">
        <property type="entry name" value="Per1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148">
        <property type="entry name" value="PER1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13148:SF0">
        <property type="entry name" value="POST-GPI ATTACHMENT TO PROTEINS FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04080">
        <property type="entry name" value="Per1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 7" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017496311" description="Post-GPI attachment to proteins factor 3" evidence="7">
        <location>
            <begin position="24"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW70345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="324" mass="37634" checksum="F3D89A3CA20154FD" modified="2019-01-16" version="1">MILRDAGFLRLPLFLLFISTVLASVGDRDPAFHECVNVCKKENCAVGSKATSIPLVHRLLLWDCPQECDYTCQHIITNQRVAASQPIVQYHGKWPFQRLWGVQEPLSVLFSLFNFLAHQDGLNKLRTNIPPKYTLRKYYCYLSYLGMASWTFSMIFHIRDFKSTEELDYFAAGASVLYGLYYAPIRIFRMDQGGRKTRSILRAWTVLCVVMFIAHVTYLKYFDWDYGYNMTANVVVGVTQNALWSWFSFNKYRKSKRTWAAWPGLVVAWLMLAMSLELLDFPPLYGYLDAHSLWHLGTVFPTILWYNFLVKDAQDDMAGQRLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8R2</accession>
    <name>A0A3D8R8R2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_08840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8R2"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF50">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="38"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="177"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW70443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="752" mass="85618" checksum="CED133C30B18EE64" modified="2019-01-16" version="1">MADVDAVALNEWDFQRGSTSPSKINREPSPNPAPKPLSCKRCRQRKIKCDRGAPCASCRRFGMECAYPPRVRTRRDPRKHQELLDRIARLENLVTKTAETRATEVPVQFPTQEIQPNPALYQIPSAEKEGIWVTESDRPISYAKPGPHKSNETHQASNHFWSSLTAEVDGLKQLLDEPSEDEEEEDNLKSTPPAHQASQPMTSMLFNESPEMVDLRAFHPFVAHARTLCDIYFSRVDPICKILHKPTIRSTIFARAHDLDVLAVERSLEALMFAVYFAAVCSVSNPECIKYFGQSKDVLSERYRFASSTALHNANFLDDVDFVSLQALVIFLVCFRQGSGSRKAWTLLSVAIRIAQALGLHRESSGSVFTPFETEMRRRLWWQLCIHDIWQSEDRAFDPIITEIDFTTLRPANIDDEDLDPSDLRPIVSRDGPTIMTFSLIAYEAYTLYSKLHFAPSVDPEIKMVKNDASGRWQQKEALAKEFCDILEEKVIKHCDTNDPYFWMCSTLAKNMQLKAFIVLRFPMRSSDMSTAPLVSKDLILGNCVIFFKLLEDLTTNQKTVPWQWMLGTWKQWHPLAVTLAELCTYKQGPLAEIGWEIINVVYEKYEERVSDAKGSRLWRPIKKLYQTAKKAREMTIFGSLQSQGQQTSTTHSWDSIEAYAASLRIADGPTLQPRTMLAYDPSGVPLTSDYGQQRFQNISMNQFSDSVFPADSAMLNTRPMEPIDWAAWNQFLADTLDVDGTLYNNMDSING</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDA1</accession>
    <name>A0A3D8RDA1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetylglucosamine-6-phosphate deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_07905</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate</text>
            <dbReference type="Rhea" id="RHEA:22936"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="EC" id="3.5.1.25"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="10">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. NagA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.25" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDA1"/>
    <dbReference type="OrthoDB" id="10264777at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008448">
        <property type="term" value="F:N-acetylglucosamine-6-phosphate deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006046">
        <property type="term" value="P:N-acetylglucosamine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00854">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000065">
        <property type="entry name" value="N-acetylglucosamine-6-phosphate deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003764">
        <property type="entry name" value="GlcNAc_6-P_deAcase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00221">
        <property type="entry name" value="nagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF14">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038994">
        <property type="entry name" value="NagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="11">
        <location>
            <begin position="64"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="8">
        <location>
            <position position="313"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="256"/>
            <end position="257"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="291"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="348"/>
            <end position="350"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010716"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR038994-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW71871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="434" mass="46664" checksum="70556B3A747B6259" modified="2019-01-16" version="1">MPSAIPTKRDKITKFTNCRLVKGDELIEQDLWVSSGTGKIVRSQEVFYSEHAVPDATIDLGGRIISPGLIDVQLNGAFGFDFSVIPEDPTTYNKTLKLVNRSLVQTGVTSYLPTLTSQRAEVYHHALPYLGPSGGMRIAEDGAESLGAHCEGPFLSPTKNGIHKVEVLTEATKFSDLEDCYGACNINPTEDALNGAKKRPQIRMITAAPEVAGMCSLIPEITSRDIIFSTGHSEATYEDACAAVKAGGTMITHLFNAMRPLHHRNPGVFGVLGIAESLPRPYFGVIADGIHLHPTTIKIAFNAHPDGFILVTDAMHLVGLSDGTYEWTNGDNIVKSGPRLTLEGSDKIAGSSITLIECVTNFLNWSGATVPQALKAVTATPAAMLGMTGVKGSLEDDADADLVIINERVEADGTKTLVIDEVWKFGSKVFDRLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDN4</accession>
    <name>A0A3D8RDN4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08193</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDN4"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW72159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="132" mass="14253" checksum="7E4808DE1DF4A91A" modified="2019-01-16" version="1">MQQDRPRPPQTLPRTCAARPAVIGWRGRGAAPLPPNRLHKASSTDLVRRAQSTSHQSALQNSDGDGRRADLAGSRSHVMRAGSASPGRHGLWIGVRGLCDRESGCVVCAWENSWADLDAGWRLTHGLGTWVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDQ2</accession>
    <name>A0A3D8RDQ2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08186</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDQ2"/>
    <dbReference type="OrthoDB" id="3526284at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW72152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="309" mass="33892" checksum="9AB660B03939CF47" modified="2019-01-16" version="1">MNTKGSPSLAYPDPDPEREEAPPSYTSSVAPSSRHPKHEKSPENIPTHYGAQINAQLHALTNSLSSLHVQRSLLAGAKDDQILSLLTESIQTYIARFSTTGLRTGTLILIPSGAVVENGQPLPTMRDPTFGNRGEFDVVMRVGDAQAEGSESPAWPEAPGDEGGDLFWWTDGDMAQRLVQALRPQIEETEKSRDGNEEQQDCKTSTEPAQQSESTQPSKASVWGFLKKSSKNSAKPQSVAAMVPQKAASHDSMPSKTGLKEVKQREPDKENVIMHIDAEQIVFRYENDFGLLQTKTGWSIIVRLTILTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDU2</accession>
    <name>A0A3D8RDU2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Amino acid permease/ SLC12A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_08226</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDU2"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="120"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="327"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="9">
        <location>
            <begin position="50"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="491"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW72192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="524" mass="56555" checksum="99F27FE9F47D9612" modified="2019-01-16" version="1">MAELHVHNESGSRNSTKSNEPAPNNSFSLDEETGQAPAADMLHRKLKARHIQMIAIGGNIGTGLFIGSGKALHTGGPLALVVGFFMVSVSLTMMMQCLGEMSVIFPIPFTRYASRFIDPALGFAVGWQYWLCWVSIFGAESSAFVILINYWNNDPHLTPLWISIFIVLNIAIHLAPVRVFGEVEFIVSSLKVVTVCVFIIIVWCIMGGAGPTGHRHGAEYWHLPGLDHGLNNGFRGLASVFVTAAFAAGGTETVGVVAGEAQNPRYNIPRAVCTLMWRVFIFYVVSMLFLTFVVRYDADTLVGGSNANSSPFVLAVRQAGILTIPDLLNAIIMVCVVSVGSTSIYTSSRTLKGLADEGFAFPCFKKTDQHGRPCIALVFSATQHGSDCVRVVHVDFRAGVLHRLAGDHCVQLAVPRCLARAERRYAAAAVCVSGDGLAVFLHSRIRPDSFHDHLPTRRLGIAHPCPAISNDVLCQLSQRSPIPHALGGVQAAVQDEGDSTGEDRFAKRSTTTRPGGGWAFGKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIP3</accession>
    <name>A0A3D8RIP3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA repair protein rhp54</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BP5796_07240</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIP3"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016817">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000010">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000332">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013967">
        <property type="entry name" value="Rad54_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08658">
        <property type="entry name" value="Rad54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="265"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="598"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="28"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="40"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDW73798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="837" mass="94328" checksum="A88D51A08C35FFAA" modified="2019-01-16" version="1">MANETLVAKKLVVPLLQTTPSANRLKQPFKISLSDDKENSPTSLSTPSQKSSQRLYGGTPQSVDRLIRPFKCPGSATISRTSEKPTRKRRKVDYGGADGEKDDEDKAWTNEDRLALANRDANKFPVFQVKDKEAMFRKRFAVPLINKDVGGYNPNRPPPTLGLRTGAKFVAKPLHDPSGEFAIVLYDPTIDEKPKTIEEAKKAQAEVPKIDAPIVTKSLADILGIKKVVEGDHPKVPVVIDPRLAKVLRPHQIEGVKFMYKCVTGMIEEKANGCIMADEMGLGKTLQCIALMWTLLKQSPDAGKPTIQKAIIACPSSLVKNWANELVKWLGADAIVPFAIDGKATKEELTSQLRQWAIASGRAVTRPVIIVSYETLRLNVEELKNTKIGLMLCDEGHRLKNGDSQTFTALNSLNVSRRVILSGTPIQNDLSEYFSLISFANPDLLGSRLEFRKRYELPILRGRDAAGSESDRQKGDECLKELLGLVNKFIIRRTNDILSKYLPVKYEHVVFCNLAPFQLDLYRYFITSPDIKALLRGKGSQPLKAIGMLKKLCNHPDLLNLAEDLPGCEQFWPDDYVPKESRGRDRDIRPWYSGKMRVLDRMLARIRQDTNDKIVLISNYTQTLDMFDKLCRHRGYGSLRLDGTMNVTKRQKLVDKFNDPNGEEFVFLLSSKAGGCGINLIGANRLVLFDPDWNPAADQQALARVWRDGQKKDCFVYRFIATGTIEEKIFQRQSHKQSLSSCVVDSAEDVERHFTLDSLRELFQYQEKTTSDTHDTFKCKRCKPDGKQYIKAPATLYGDTSTWNHFVNEGLKSIQDLLLRQESEEDAVSAVFQYISH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJ66</accession>
    <name>A0A3D8RJ66_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">6,7-dimethyl-8-ribityllumazine synthase</fullName>
            <shortName evidence="7">DMRL synthase</shortName>
            <ecNumber evidence="3 7">2.5.1.78</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_07527</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>(2S)-2-hydroxy-3-oxobutyl phosphate + 5-amino-6-(D-ribitylamino)uracil = 6,7-dimethyl-8-(1-D-ribityl)lumazine + phosphate + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:26152"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15934"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58201"/>
            <dbReference type="ChEBI" id="CHEBI:58830"/>
            <dbReference type="EC" id="2.5.1.78"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 7">Cofactor biosynthesis; riboflavin biosynthesis; riboflavin from 2-hydroxy-3-oxobutyl phosphate and 5-amino-6-(D-ribitylamino)uracil: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the DMRL synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.78" evidence="3 7"/>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJ66"/>
    <dbReference type="OrthoDB" id="2965at2759"/>
    <dbReference type="UniPathway" id="UPA00275">
        <property type="reaction ID" value="UER00404"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009349">
        <property type="term" value="C:riboflavin synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000906">
        <property type="term" value="F:6,7-dimethyl-8-ribityllumazine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009231">
        <property type="term" value="P:riboflavin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09209">
        <property type="entry name" value="Lumazine_synthase-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.960">
        <property type="entry name" value="Lumazine/riboflavin synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00178">
        <property type="entry name" value="Lumazine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034964">
        <property type="entry name" value="LS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002180">
        <property type="entry name" value="LS/RS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036467">
        <property type="entry name" value="LS/RS_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00114">
        <property type="entry name" value="lumazine-synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058:SF0">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21058">
        <property type="entry name" value="6,7-DIMETHYL-8-RIBITYLLUMAZINE SYNTHASE DMRL SYNTHASE LUMAZINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00885">
        <property type="entry name" value="DMRL_synthase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52121">
        <property type="entry name" value="Lumazine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0686">Riboflavin biosynthesis</keyword>
    <keyword evidence="5 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW74085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="179" mass="18477" checksum="2AD88BF10C771F5D" modified="2019-01-16" version="1">MALLSRSAIIEPLLNGTKKALLASGVQESNIVVQSVPGSWELPIACSKLYSASQVQSTSSSTLGAGDLLGGSTSDLTSLSTTNSASTAPFDAVIAIGVLIKGETMHFEYIAESVSHGLMRVQLDTGVPLIFGLLTVLNEDQALARAGVASGSHNHGEDWGAAAVELGVKRREWAAGKIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJL7</accession>
    <name>A0A3D8RJL7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_07598</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJL7"/>
    <dbReference type="OrthoDB" id="189968at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000594">
        <property type="entry name" value="Small nucleolar ribonucleoprotein complex subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039241">
        <property type="entry name" value="Rrp9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="224"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="265"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="307"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="546"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW74156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="564" mass="62410" checksum="8CDCCC4192D152B1" modified="2019-01-16" version="1">MSSFFTIPGAQKKRKRTENSEVPKKRFATSKAPSKSNKAPPKKAQRDESISGSDSESDGPAAEEDEAETSGSESGEEETAAERRLRLAERYLENIREEVVDPEGFDAEDIDRDLIAERLQEDVAESKGRIYRNLADELDFKDARHSLFRNNTETVTAVAVCAPYTYTVSKDMALTKWRIQDLPDEQWKVKKKKKKGWKPVPARRVPEQVAYVRGDKREAKNNAYQGHTDSILCVATSQDGNFVVTGGKDRRLIVWDANLKPLRVFSQHRDAVTGLAFRRGTNQLYSASKDRTIKIWSLDELAYVETLFGHQDEVVDIAALAQERCISVGARDRTARLWKVVEETQLVFRGGGTGKKSKSIALEGSMDCVAMIDEEMFVTGSDNGSISLWTMHKKKPIFTLPLAHGVDPPLKHDEASAETNPSLAVIPPAQPRWVTALTTIPYSDVILSGSWSGDVRAWKLSDDKKKIEELGAISSTVNGEETEQKAAKGVVNSISVFERGDRAKDGICVVVATGKEHRLGSWQRKHIPGAKNGAVVFEVARASKENGTNGVNGTTDTDFEGLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJM8</accession>
    <name>A0A3D8RJM8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_07608</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJM8"/>
    <dbReference type="OrthoDB" id="410198at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="64"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW74166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="212" mass="23826" checksum="4B9ED3FB212000EF" modified="2019-01-16" version="1">MADPTISIQLASDADARHLAALMTAAFSASDAVYPLIWGKVDSKVHDLISERGLFTPVQKEGRMTYKAVDAEGMILGFATWTLPTERKETKEGDGLPDLPGVNMELWTVKVLGMRQYSDRDVDVEKDMFLQYLFVDPAYHRRGIGSLLLEWGSQKADDLQAKVWLTSTPVAVKAYEKNGWCVKETHEILLGQYGGEGTYTRAWMLREPRRVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJN2</accession>
    <name>A0A3D8RJN2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_07546</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJN2"/>
    <dbReference type="OrthoDB" id="3266505at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF32">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="2">
        <location>
            <begin position="161"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW74104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="268" mass="30216" checksum="C97682E9DAAD6AF7" modified="2019-01-16" version="1">MVTDRMPQIDSPEDPYNMDGTAVTFRWTRISEDKDPDISDLPSFDYSLYLFNAVKFYLGQLFNIIDEESFMQSLNEFYEDAATKSRLSRTWYCQYLLVLAFGKAFVVTPETPSSPAGSKYAARAMGMLPDLTDIRDEPLLAIEVLCLAALYFESIDMRVAAYQHIGQALRICFIEGIHREVSEGAVGSKVSQRCSTVWWTVYILDREFSALLGAPSSVREEDITTALPSERDNSLRAAATTLQIQLARLTSRILTSVYQATCFLEIIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RNR7</accession>
    <name>A0A3D8RNR7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_06417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RNR7"/>
    <dbReference type="OrthoDB" id="5204927at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="278"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW75596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="307" mass="35344" checksum="1BE2C6890E2666F8" modified="2019-01-16" version="1">MVMVNNGGLVLERPEIKPSRSMTHPLRDPKAGKHRTKNGEPFDPSELSRRLEAHLKEQKRLRSERRASKAAAAATSQKQEPYHHVPKVAASSFARTTTQDKPRKIHRLSQIVLQEQVKNFSLDDPHTGQPLVGLQRSIAQDQVVIKQENLRSRNQFQWTQYMEKAVEVDADRDVYRAPQRTFETGILATQNGRIHSRVPRPLSTGDLQLEDDDTPLIRNKQKLKPFHQNDWLQKDDNDDDSETRRKTKERGGPFSRKRDSVWIMKGRREKPTADEGTPTPNACQNVSTLDNKASRGKFLSRFRWHPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RP96</accession>
    <name>A0A3D8RP96_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="12">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_06601</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a very-long-chain acyl-CoA + malonyl-CoA + H(+) = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:32727"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:90725"/>
            <dbReference type="ChEBI" id="CHEBI:90736"/>
            <dbReference type="EC" id="2.3.1.199"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="12"/>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RP96"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF134">
        <property type="entry name" value="ELONGATION OF FATTY ACIDS PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6 12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="3 12" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8 12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="238"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW75780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="354" mass="40081" checksum="01954288FE6AB5A2" modified="2019-01-16" version="1">MASIMENTSLPFMPFSGFSGSSSPESNSVIGPVNLSPWATFNKLWTSLKGYPADNFEFIPGKTPFSTLGETVFMIVLYVCVVFGGREWMRNRPAYKLNTLFKIHNFCLTAISGTLLVLFAEQIIPTVWKNGLYNGICGTGGWTDPLVTLYYLNYLTKYIELLDTVFLFLKKKPLTFLHTYHHPATALLCYTQLIGHTSVSWVPITLNLFVHVVMYWYYFQSARGVKVWWKEWITRLQITQFVLDLGFIYFASWDYFSSTFAPWLPHVGRCAGEPFAAIAGCVILTSYLFLFISFYIATYRKAGRKSAKTKAQTAALDMKHTQVPTAQKTKETATKVVEAANVSMHKLSPSGTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RV02</accession>
    <name>A0A3D8RV02_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GroES-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_05735</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW77883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RV02"/>
    <dbReference type="OrthoDB" id="9992527at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052585">
        <property type="entry name" value="Lipid_raft_assoc_Zn_ADH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482">
        <property type="entry name" value="PROTEIN AST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482:SF1">
        <property type="entry name" value="PROTEIN AST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="1">
        <location>
            <begin position="25"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW77883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="179" mass="19394" checksum="4BB347EB710036F4" modified="2019-01-16" version="1">MQKAIFVTEVGKPVSLGTRPIPAPGPEEVLIKVSSTMLFPHDTYGRDMGLFIGKKLPFISGGDIAGVVLKVDDNVNKYTVGQHIYGQGRMLDPTPDSAGLQEYAILRPDFSALVPLGFTVDQLVTLPINATTSFSALFHQNWFGFTPPFPSVEQNSRSNYAEETIVIIGAGSNVRKLAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVC8</accession>
    <name>A0A3D8RVC8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_05807</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW77955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVC8"/>
    <dbReference type="OrthoDB" id="3636394at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF23">
        <property type="entry name" value="MICROBODY (PEROXISOME) PROLIFERATION PROTEIN PEROXIN 11B (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW77955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="242" mass="27287" checksum="04FE22D42BBA90E6" modified="2019-01-16" version="1">MVNIILRTSKFVNDAAGLEKTLRLLQSLSLIIAANVVQPAGWNQAKKQFALGRRYLRFTKFIDCFNTAYSAFSAPGSEKSGVVVLLEVGKWSCLGIYLLLESFTIMDAMGIWSTTWAPKLFKEAMKFWFYSLTCSLVLSLNSMKTLYMRPLVEIQAKKGSGDERIDEKSEKSEESAKIELAKKQWYGERQVLMKKVIMDSCDLFIPATAVGWVVMRPDLLGMIMVTGTLLGCIDIWNRVNPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVG3</accession>
    <name>A0A3D8RVG3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative hydantoinase oxoprolinase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_05706</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxoprolinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW77854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3643at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017168">
        <property type="term" value="F:5-oxoprolinase (ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049517">
        <property type="entry name" value="ACX-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008040">
        <property type="entry name" value="Hydant_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002821">
        <property type="entry name" value="Hydantoinase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003692">
        <property type="entry name" value="Hydantoinase_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045079">
        <property type="entry name" value="Oxoprolinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365:SF9">
        <property type="entry name" value="5-OXOPROLINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11365">
        <property type="entry name" value="5-OXOPROLINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19278">
        <property type="entry name" value="Hydant_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05378">
        <property type="entry name" value="Hydant_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01968">
        <property type="entry name" value="Hydantoinase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02538">
        <property type="entry name" value="Hydantoinase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hydantoinase/oxoprolinase N-terminal" evidence="4">
        <location>
            <begin position="10"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase A/oxoprolinase" evidence="2">
        <location>
            <begin position="242"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Acetophenone carboxylase-like C-terminal" evidence="5">
        <location>
            <begin position="548"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="Hydantoinase B/oxoprolinase" evidence="3">
        <location>
            <begin position="738"/>
            <end position="1274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF19278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW77854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1318" mass="142297" checksum="CAD8552F1982FD64" modified="2019-01-16" version="1">MPSAMPAGIRIAIDRGGTFADFWASIPNRKEDVVFKLLSVCPDQYEDAPTEGVRRILELATGTSIPRGTPLDLSSVESIRMGTTVATNALLERKGERVALLITKGFIDLLVIGNQARPNLFDLSVKRLDKLYEKVIEVDERVTIEGFTEDPEPQPIDISSDPDLVEGLSGEAVRIIKRPDYSNIRKDLQGLWDEGFRSLAIALMHSYAYSEHELTIAGIARDMGFKIAVSSQLQPMIKIVPRAQSATADAYLSPITQDYLANFAKGFQGEFKDVQNLNKLLLSQSDGGLVSFQKFTGLRAILSGPAGGVVGMAKTCWDKTDGTPVLGFDMGGTSTDVSRFDGAYEHVFESTTAEVTIQSPQLDINTVAAGGGSMLFWRNGLFVVGPDSAGSFPGPACYGKGGPLTITDANFFLGRILSDYFPNKLDFEATKEKFLALTLEVNAGKHGADQLSAEEVAMGFLSVANASMTRPIRTLSEGRGFETAAHNLACFGGAGGQHAAAVARDLGIKRVLIHRLSSILSAYGMALADVVVEVQEPESVAFSKDSIARISQRIEGLRQKAIAGLISQGFTAEQVVHENFLNMRYRGSDTSMMISQPEKIESFADAFTARHMQEFGFTQPRDILVDDIRVRSVGRGMDVQVSSAFEQLEALDDFPYLGRDYAASTRKVYFEKTGWTDSNVYQLGDLPRNQKISGPAIIIDATQTIVLDPAAEATILAEHVVIELLDTEKKAIGLESVDPIQLSVFGHRFMSVAEQMGQTLQKTSISTNIKERLDYSCAIFSADGGLTANAPHIPAHLGSMSYAVAYQAKRYPNKGDLKPGDVLLSNHPAAGGTHLPDLTVITPVFDDEENPTEILFFVANRGHHADIGGIAAGSMPPNSTELWQEGAAIESFKLVKEGLFDEAGLIHHLVDIPSSYPGCSGTRTLKDNIADLKAGIASNNRGIQLIGALIKEYSWPVIQFYMTAIQKNAEESVRELLKTFSVRFRGQPLEAIDYLDDGTELVLKITIDGKTGSAKFDFTGTGPEALNNLNSPPAVMYSGIIYCLRSLISSDIPLNQGCLTPIEVFCPPNTILTPSLKSATIGSNVETAQRIIDLIFKAFRAAAASQGTCNNLTFGYGGTDEKGNITKGFGYYETIAGGAGAGADWEGQDGVHTGSTNTRMTDPETFEKRYPVILREFSIRKGSGGGGRNPGGNGCIRDIEFRRPMQVSILSERRVIAPYGMAGGSDGQRGKNLWVKVDPTDGTTRTISMGGKASIMAGVGDRVIIQTPGGGGYGGIGTKTEQEQEFGEFKLHKKFIRNPHLFRASGSVGNREALGNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVX6</accession>
    <name>A0A3D8RVX6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NADH-dependent flavin oxidoreductase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_05866</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVX6"/>
    <dbReference type="OrthoDB" id="72788at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF2">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE PYRROLE 2,3-DIOXYGENASE (AFU_ORTHOLOGUE AFUA_5G01450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="2">
        <location>
            <begin position="29"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW78014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="416" mass="45454" checksum="CFCA71E82D334E81" modified="2019-01-16" version="1">MASASDIPYYTPRQSPPAGTALDDNPPTLFSPLKLRDLTVQNRIWVAPMCTYSAQDGHLTDFHLVHLGAFALRGASLTVIEATSVLPNGGITPQDSGLWKDSQIAPIKRVADWVHSQGQHIGIQLAHAGRKASTIPPWLVERGKSAVASKEIGGWPDDVMGPSAIQWGEGYVKPREMTAQDIQDVITGFADSAKRAIAAGVDVIEIHAAHGYLLCSFLSPISNRRTDKYGGSFENRIRLLLEVIQAVRAVIPQGMPLLVRVSSTEWMEESDEPESWDVPQTIELAKLLPSLGVDLLDVSSGGNNEKQQIKLSNNFQVGIAGQVRRALYSAGITNLLIGAVGLITEAEAAKEIVQEKEGTVQMTDEQGGLADANIVLVARQFLREPEWIFRVAYRLGVEVQWPVQYHRGTFLKNSRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RW63</accession>
    <name>A0A3D8RW63_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_06161</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RW63"/>
    <dbReference type="OrthoDB" id="4540492at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF31">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="251"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="306"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="1"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW78309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="450" mass="49001" checksum="B8FDD0E54EA6BED5" modified="2019-01-16" version="1">MYHILLWLGGAISGFFYGYVVDAMGRKPALFWAALFTIFAAILQAAAQNVAMFVIARILIGIGTGASGVAGPVYLAETLPLKWRAWGLGVFYDFWYVGGLIASGVTYGTAGMASTWAWRLPSALQGVFSIICILILPFIPESPRWLIYQGRNEEAKKIIAYTSCDGDENNPIVLVQYKEMVETLDFEKNAGETLSMMEIVKTPSARKRTMLACSVAVCTMLSGNNIISYYLGTMLDNAGITNSTTQLEINIILNAWCLVVAICGTLFVERAGRKSIAACSTGLLTVFIFVIGALTKVYGNTTNTSGIYGTVAAIFLFQGSYSFGWTPLTVLYPPEVLNYSIRSNGIAFYTFMANGLGLMVTFAFPYALAAIGWKTYMINGAWDILELAFVLLCWVETKGKTLEEIDEMFDGAKHTNAPDLESVMAGKADLEVLDGEEPVVEELPVTAGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWE4</accession>
    <name>A0A3D8RWE4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aspartate/glutamate racemase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_06219</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWE4"/>
    <dbReference type="OrthoDB" id="412093at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW78367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="265" mass="29278" checksum="CD92FDD2FE96262C" modified="2019-01-16" version="1">MSSQQMPKLGVLQLKTTFPRPPGDVGHPKSWGGIPVVIRVVEEATSSLVVGGGWGMELVDAFVREAEKLIVEEGCVCFVTSCGFLATMHPLLAQRIPYMGTTSLLQVAWLQQSFFPGEESKESVGVITYKKSSLVSIMIIEFIVCVIEDLKAEKRNLQIQTEKHLTSVGAHPETPVYGLPEDPKTAIFKGVLEEHDYEGMESEVLAAAQELVAKHPKIKAIVLECTNMPPFSHAVEKATGRRVWDILTLGRWLYDGAIPRDHRTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWG5</accession>
    <name>A0A3D8RWG5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoribosylaminoimidazole-succinocarboxamide synthase</fullName>
            <ecNumber evidence="3">6.3.2.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">SAICAR synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_06271</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAICAR synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.2.6" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWG5"/>
    <dbReference type="OrthoDB" id="9991235at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00131"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004639">
        <property type="term" value="F:phosphoribosylaminoimidazolesuccinocarboxamide synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01414">
        <property type="entry name" value="SAICAR_synt_Sc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000015">
        <property type="entry name" value="Phosphoribosylaminoimidazole-succinocarboxamide synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00137">
        <property type="entry name" value="SAICAR_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028923">
        <property type="entry name" value="SAICAR_synt/ADE2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001636">
        <property type="entry name" value="SAICAR_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018236">
        <property type="entry name" value="SAICAR_synthetase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010568">
        <property type="entry name" value="PRK13961.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00081">
        <property type="entry name" value="purC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43700:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01259">
        <property type="entry name" value="SAICAR_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01057">
        <property type="entry name" value="SAICAR_SYNTHETASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAICAR synthetase/ADE2 N-terminal" evidence="10">
        <location>
            <begin position="17"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW78419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="313" mass="34960" checksum="F4682628B2E0B511" modified="2019-01-16" version="1">MSSEALTTIPLTSLPRLSQGKVRDLFALPDDSKLLFVTSDRISAYDVILKNGISSKGLILTLLSAKWFEVLSSKVPGLKHHFLGLTPPPAPSVVTPDERQMLRGRSMTVRRLKIFPIEAIVRGYVTGSAWSEYEKSQTIHGLPQPAGLLCCQRLPQPIYTPSTKAELGDKDLNITPDQARAIVGDKYASRIEDLVLACYKAGVAYAEERGILIADTKFELGLDEETDEIYLVDEVLTPDSSRFWSKADYQVGRQQDSFDKQVLRDWLTSNGLKGKPDVQLPPEVVEKTKARYMEAYEKLTDRTLEEALKSLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWH0</accession>
    <name>A0A3D8RWH0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_06178</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWH0"/>
    <dbReference type="OrthoDB" id="3365563at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046964">
        <property type="term" value="F:3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF13">
        <property type="entry name" value="ADENOSINE 3'-PHOSPHO 5'-PHOSPHOSULFATE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW78326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="353" mass="38251" checksum="8C3FFF15363A8B2D" modified="2019-01-16" version="1">MAASKGEQSPNFIPLVLKTIALIGIYASYGLLQERIIKGTYENPSLGTVDKFHSPPLLVLCNRVVSFGAGLVLAGLFSFHYAGEEPSLPQNTATASSSWLSRFWKSIKPASPLRSYAIVAGLNNVATLSQYASLSYLSFTTSTLAKSAKMVPVLIIGYTFYQKRYKPRQWIGALVVILGIWMYLTSLGENVKSKGKKESEKQEGMWGVIFVLAYLFFDGLTSSFQEKLFGHAKGKDSSEGGGRAVTLWGISRGVVDQMHAYAQPALNHPSLPLAGPQQHYSPIPHLPPQSHSHRGTAAPVPCDLLARRVGGGADHDDPPICQHRVQRDGVWESGGCADQRVGGRGLAGRRGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWI8</accession>
    <name>A0A3D8RWI8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_06237</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWI8"/>
    <dbReference type="OrthoDB" id="2115692at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="97"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW78385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="235" mass="26420" checksum="F1207C82043A93C3" modified="2019-01-16" version="1">MPPYQVQPCDAAHAQGIANANMRAFNQDPHWRLVWPKTLTIEEIIDGNANRLPKQLSNSRETTRHEMAVDTETGEVVGYARWEFLHCPGSEALWKEAQTKEPTEEEAMEYEKSFKLHTDEEGRTKYVNREITSSYGKILHNETQKVVGGRPFLELDHLGTLPSHGRRGVGGMLLDRGVAQANALGLPIFVMAYPHGTGLYTKHGFKLMSTVTLDYSKYSDIGPQTVSFFVKEPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3I0</accession>
    <name>A0A3D8S3I0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_05565</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the proteasome inhibitor PI31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3I0"/>
    <dbReference type="OrthoDB" id="68090at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004866">
        <property type="term" value="F:endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1000.30:FF:000006">
        <property type="entry name" value="Chromosome 8, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045128">
        <property type="entry name" value="PI31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013886">
        <property type="entry name" value="PI31_Prot_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021625">
        <property type="entry name" value="PI31_Prot_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266">
        <property type="entry name" value="PROTEASOME INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13266:SF1">
        <property type="entry name" value="PROTEASOME INHIBITOR PI31 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08577">
        <property type="entry name" value="PI31_Prot_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11566">
        <property type="entry name" value="PI31_Prot_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0488">Methylation</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PI31 proteasome regulator N-terminal" evidence="13">
        <location>
            <begin position="28"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="PI31 proteasome regulator C-terminal" evidence="12">
        <location>
            <begin position="284"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="198"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="277"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="304"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="351"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW80867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="377" mass="40311" checksum="1A824B8F327C597B" modified="2019-01-16" version="1">MASNPLSTESILKHMAEALPTHKKGDTNSDISSSYEAIALFAHACMIAVGFRLIGYSEGQKTEAECRELAPRMSEKWNSTFNSHSFVYAHSQSSMEYVVKVDRLGGKAEIRGIGLGDERITRFEVVAKDYISSAALPLRIQMTEEGEEDRSTLEDKLKEVFISPSRIQDFASLFKTQIVQKLMPSLQKEGYEESIAADARDDMRDQREAAHAQRTGRDQPPRQPDALPEPARPYPFADPLASGPRGTLPDGGFAPPGFDDEYDLNRPLRGMAPPFPGAGSPFGIGHNDLNPPGLGPNDPLRGSFVGGGPGGFGGNGGMHPTFDDPLFGGRGGQGGFHPHAPPGSRYDIPGPGFGGSPRGSGGAPPNPFGGFGGNDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S409</accession>
    <name>A0A3D8S409_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA exonuclease 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_05529</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S409"/>
    <dbReference type="OrthoDB" id="8191639at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06144">
        <property type="entry name" value="REX4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000007">
        <property type="entry name" value="Interferon-stimulated exonuclease gene 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037431">
        <property type="entry name" value="REX4_DEDDh_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF45">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exonuclease" evidence="11">
        <location>
            <begin position="128"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="16"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="290"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW80831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="313" mass="34344" checksum="96B1E00B394FBECA" modified="2019-01-16" version="1">MAPELSSNWKRLQATLKQESEASAERKRKAVPSQKSLNSIAKRRRLEGIQGKDTVTSGRIGKASKMDAGSDKEKVAPSASLALWAEDNDISAKDLAEAYGESLTATNAKATAEDKINGGLSEDVEIGKYVAMDCEMVGVGGDEDRSVLARVSLVNFHGTQIYDSFVRPKEFVTNWRTHVSGVASKDMAKARSFDVVQKEVGDILTDRILVGHAIKHDLEMMMLGHPKRDIRDTSKFSGFRKYSAGKTPSLKKLAKEILGVDIQGGEHSSIEDARATMVLFRRHKSAFDVEHAQRFPTHPSGSSNKGKKKKSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S459</accession>
    <name>A0A3D8S459_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_05552</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S459"/>
    <dbReference type="OrthoDB" id="3163292at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF21">
        <property type="entry name" value="REGULATORY PROTEIN LEU3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="13"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="85"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW80854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="556" mass="62574" checksum="8CC8ED895C4C59A2" modified="2019-01-16" version="1">MSSSGKRFRSSSSCTVCRQLKMKCDRKERLPNRCTRCEKTDQTCELSTTFERKRMKGPYRDDEETRRLRQELEQLKAQVATLKPHEPIPQTPEVEPDITSPSLSTGSSIRPARPHSSDITIQRSANGIIVLPWQIDTSFATFFRQMHPFLPFLEEVTPNACYEKEPFLFWTICMLGLRSFCPELSKAIGDFVAVEALQAPIRCCHNQAAAAAVVQGLLLLSLWPFACPSLLHEAAWIHCGSATHLALHIGFHQPYAASEFVPKREREHIPNSFTEFRRTWIATAEKLSISPDLFKALLIARRIEEGQDLGHSRTGTHGQIDPGSREGIFRLLQSRISDTEKRASPLSPYISMIITAAKLQPAIQVLQSTTPISLQETTVLSACDNACQVITFARIVQGQTNMVHLPVFVDSLVLMSAVLIFKIHISRFSSLINGQVAQSQISEACSYFHDGINDFSDVPNRVGIFVEALYTLVAENLVPVGGFVIENTKSRYSQNILYEVLWTFKEWKRQKIEAATIQQEQTVYAPINPNPAMEATFSFLDADQLDHGFWQMVEGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SA94</accession>
    <name>A0A3D8SA94_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04694</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SA94"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW83203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="181" mass="19432" checksum="81DCC8B1FDD3FFFA" modified="2019-01-16" version="1">MGEGGSTHRMAWYAGVRCLSLRMSHGNGRVRESTYLRCAATVPEQRGSGMSPPKLIHRPMLPIRRYCIWGSLDFPMNSSAEEACSLAGCEAPHSTASRVASPPHLDPLVAWSTQAPPGPPFPSDPPRPPAPHWTPGPLAGSTRGASANPTTTLDSCRAAVPAWYGMRPRDQTGQQPQLQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAR0</accession>
    <name>A0A3D8SAR0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Trans-aconitate methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_04953</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAR0"/>
    <dbReference type="OrthoDB" id="66144at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030798">
        <property type="term" value="F:trans-aconitate 2-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.290">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023149">
        <property type="entry name" value="Trans_acon_MeTrfase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002463">
        <property type="entry name" value="PRK01683.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF1">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="4">
        <location>
            <begin position="53"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW83462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="277" mass="31101" checksum="A8E52BD5191A3883" modified="2019-01-16" version="1">MSSSTPTHRAFGSSAAKSAKDWSAAQYLKFEEERTRPSRDLLSQIPLKAPKSIIDLGCGPGNSTAVLAEQFPDAQIEGVDSSADMIEKAKKTLPSVDFSLQDLTTYVPKEPVDLLFSNAVFHWLPSKERINIIANLIKSQRSGGVFAFQVPDNFTEPSHAAMRSVAEQKPWAATLSSLHPALPQFQSAQEIYNQLQPLCSSINIWHTYYYHVLEDHQAIVEWVKGTGLRPFIDPLSEEERKSYLEAYLNRIKEVYPSSQDGKVLLRYPRLFMVAVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAX9</accession>
    <name>A0A3D8SAX9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_04947</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAX9"/>
    <dbReference type="OrthoDB" id="431212at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005345">
        <property type="term" value="F:purine nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015853">
        <property type="term" value="P:adenine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015854">
        <property type="term" value="P:guanine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337:SF3">
        <property type="entry name" value="PURINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="XANTHINE/URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="566"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW83456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="585" mass="63021" checksum="A45952A7ACF2AC44" modified="2019-01-16" version="1">MFSIRDTIDVIDAKIAKSTFARVFRLDGCGHEKERPGSKFVTEIRAGITTFFTMAYIIAVNASVLTESGGTCVCTSTTDPSCSTDADYAQCLIGINRDLVTATAALAGLGSIVFGFLTNLPVALGPGMGLNAYFTYQVVGYHGTGPVSYRLALMAVFVEGFIFVFLSLVGMRQWLVKIIPASIKTASGVGIGLFLTEIGLSYSAGIGAITGSSVTPTNLGGCPPQYLAVDGSCSSHQMQNPTMWIGILCGGMVTSYLMAYRYKCAIIIGIALVSILSWPRNTSFTYFPHTAEGDTRFEFFKKVVDFHPIQHTLAAQEWNVSNAGNHFALALFTFLYVDIVDCTATLYSMARFSGVVDPETGDFPRSTLAYCTDAIMISIGSVFGCSPVTAFIESGAGITEGGRTGLTAIVTGTCFLISIFFAPIFASIPPWATGCTLILVGCLMMRQVVNINWTYIGDALPAFVTIVCMPFTYSAAYGLIAGLMVYTILNSAIALTRIISKGRVQPPDADSAEYWTYKPHGGVAPWFVRVVQNRGRFWDHPIDDVFEVNSVEETLPRRQKEMVTVRGGGLGRSASDASRNTESRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SB02</accession>
    <name>A0A3D8SB02_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SB02"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW83470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="35789" checksum="713316C9D7DFF99B" modified="2019-01-16" version="1">MTEHTTQGSVDDGGGDEHHQDHDPALVLDDTASTTSTTSSVLNYQYENGRRYHAYHAGAYFMPNDEREQESMDLWHHIDMMILEGRLFLSPVQNPQHVLDVGTGTGIWAMDVADEFPSAHVIATDLSPIQPEWVPPNLDFEISDCESDWDYSAQFDLIHIQNLSGAIANWPRLLEQACASLKPGGWLEVSNMDGPYSNDGDLPVGSSCAEWSARLYEAAGLMKREIARGDRMLELIKDTELLEIQHRVVKLPHSPWLPGRKNKELAMYFGVLALDELEGLSLALFTRLLGWTTDRVNVLLAGVRNDFRNKDYQLHVNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SG94</accession>
    <name>A0A3D8SG94_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_03690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SG94"/>
    <dbReference type="OrthoDB" id="3360610at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004493">
        <property type="term" value="F:methylmalonyl-CoA epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046491">
        <property type="term" value="P:L-methylmalonyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07257">
        <property type="entry name" value="THT_oxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07267">
        <property type="entry name" value="THT_Oxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.180.10:FF:000034">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004360">
        <property type="entry name" value="Glyas_Fos-R_dOase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051785">
        <property type="entry name" value="MMCE/EMCE_epimerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037523">
        <property type="entry name" value="VOC_core"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048">
        <property type="entry name" value="METHYLMALONYL-COA EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43048:SF3">
        <property type="entry name" value="METHYLMALONYL-COA EPIMERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00903">
        <property type="entry name" value="Glyoxalase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51819">
        <property type="entry name" value="VOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VOC" evidence="3">
        <location>
            <begin position="202"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW85365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="368" mass="41652" checksum="D2CA038C5DC46F43" modified="2019-01-16" version="1">MDRVQSDTKPGAVEELSPNRGASVPDTVAVSSEREGLKSWRERNNIDTTKQIKLVKLIHMRYQHPDLGEITEFLRDFGMNVAKKTDDEIWYGGYGPDQYVYYARKGPNQFLGGCYEVESYADLEKAAKLPGAGEIEAMKNDPGNGFMITIIDPEGFPVNLMYGQTAAEPKSYPKPILINHEAEKPRVRRFNRFEPGPAAVHKLGHYGLCVQNFDSQVEFYTRNFNLVPTDFLYIDEPAVVAHSPTNKRDVALFAHIDRGENLVDHHTFFMSTNKTSHVHHCSFEVHDFDTQNLGHQWLAKKGYKSVWGVGRHILGSQIFDYWWDTTGNMIEHYADGDLVNEHTPIGYGPVGDESLAVWGPEVPSTFLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SGH7</accession>
    <name>A0A3D8SGH7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparaginase</fullName>
            <ecNumber evidence="2">3.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_03708</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-asparagine + H2O = L-aspartate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21016"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="EC" id="3.5.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the asparaginase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.1" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SGH7"/>
    <dbReference type="OrthoDB" id="542841at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006530">
        <property type="term" value="P:L-asparagine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08964">
        <property type="entry name" value="L-asparaginase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1170:FF:000001">
        <property type="entry name" value="L-asparaginase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="entry name" value="L-asparaginase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004550">
        <property type="entry name" value="AsnASE_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020827">
        <property type="entry name" value="Asparaginase/glutaminase_AS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00520">
        <property type="entry name" value="asnASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707:SF28">
        <property type="entry name" value="60 KDA LYSOPHOSPHOLIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11707">
        <property type="entry name" value="L-ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500176">
        <property type="entry name" value="L_ASNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00144">
        <property type="entry name" value="ASN_GLN_ASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="L-asparaginase N-terminal" evidence="10">
        <location>
            <begin position="5"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="Asparaginase/glutaminase C-terminal" evidence="11">
        <location>
            <begin position="217"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="active site" description="O-isoaspartyl threonine intermediate" evidence="5">
        <location>
            <position position="14"/>
        </location>
    </feature>
    <feature type="active site" evidence="8">
        <location>
            <position position="94"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="94"/>
            <end position="95"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW85383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="323" mass="34180" checksum="50FB07D460662F5E" modified="2019-01-16" version="1">MALPHITIFATGGTIAGSASCNTQTTGYKPGAIGIQSLIDAVPAITNVAVVTGVQVSNFRSTEITSPILLEICRGINAALESDDCQGVVITHGTDTLEETAFFLSLTLRSPKPVVLVGAMRPATAISADGPINLLQAVTLAACKEAIGRGPLIVLNDRISSGYYTTKTSASALDTFKAPEQGHLGYFDNNKPKFFYTPALPVGLQYFDVTSQPDLPQVDIVYGYQGLNPNIILEHIKLGAKGIVLATMGNGGWTVAGMEVVDRVIKEGIVVVYSHRSQDGTVSLAKDISISSGLLRPEKSRILLQLALSAGYTSEKIKSIFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SGS8</accession>
    <name>A0A3D8SGS8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_03679</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the avfA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SGS8"/>
    <dbReference type="OrthoDB" id="10254604at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020">
        <property type="entry name" value="FLAVIN REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15020:SF50">
        <property type="entry name" value="UPF0659 PROTEIN YMR090W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13460">
        <property type="entry name" value="NAD_binding_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="2">
        <location>
            <begin position="8"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW85354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="253" mass="27718" checksum="33EF5FD273CE6ADC" modified="2019-01-16" version="1">MPSVLIFGGSGKIAKFITASLVKQDYKVYSVIRREDHVPELRGLGATPIIQSLEDSTVAELTATIKSSIPDVVIFAAGAGVRAFEDPSLSILVDRDAAIRIFDAIAEANCTKRLITISTIDARNRDKPSPTWYNEEDQKGSDELWGMLPIYMKAKFEADKDLVAQNSRRGLEYTIIRPTWYGDGEPTGKVKAGLAGISPKVSRNDVADVFVACIENPATVGCVFEVSGGEVPIKEAIQRVAEERVDSFDEMYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SGV4</accession>
    <name>A0A3D8SGV4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03885</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SGV4"/>
    <dbReference type="OrthoDB" id="3446835at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017831355" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW85560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="9896" checksum="0967708D6020C602" modified="2019-01-16" version="1">MQFSLIAGITSAVLIGTSLASPLVEKRTVVEECKAANDCCFSTINACRRQASVLEANVICRILDFCPSMGVSFADCNADCCSISRKAGRGCPGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHJ4</accession>
    <name>A0A3D8SHJ4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_04144</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHJ4"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF3">
        <property type="entry name" value="CLC CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="380"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="477"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="705"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW85819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="761" mass="83148" checksum="8799F23C7CF8DA1D" modified="2019-01-16" version="1">MPQNGDSHERSPLLDPQLFDPHRAGRGHGQPEDVTSVISSTVSKREQSLGSTTIGERLPYNSYTTIDWLHDLIKDSFRYRAIHSKRGLRARLLAGWDSCQGWVAAAMIGIFTALVAFVVDVAEATIADYKLGYCSTSFLRNREICCTGNSPLLPASKEPVVDNCPEWKMWSNNYWGTFAIYVGFALLFGIIAGSVTMTTKATLPAVREGDHGKIGGKQGHLEVKTMYMAAGSGIPEIKTILSGFVIPHFLDFKVLFVKAVGATFAVATGMCLGKEGPFVHISTCAGYLVANLFPKYRENERKMREMLSVACSAGLSVAFGAPIGGVLFSYEEISTYFPRKVLWRSFLCSLFAAVVLKALNPTGTGKLILFETKYGVSYSPVHYLVFIFLGVAGGIFGGVFCRANFLWSKTFRKYRIISDHPVFELSLVVLATALLQYPNPLIREPGDVIMKNLLVDCIHPEGSWVCNQEASKEKARYYAWLVHGTAIKLILTIITFGCKVPSGIIIPALDAGALFGRLVGQLIPNISPGIFAMVGAAAFLAGVSRMTVSLTVIMFELTGEVDYIPPFMITILVAKWVADALSSEGVYDLAQTVLGHPFLDPEHALALVRDEGALVEELIPPVQTMREITVEVGLSFTIPKSILAMKLSQLKARGLMDAGLVLVDSNGMLHGYLAEGELEFVLQKGGILNNSESINLVEGPLSKFVDRTPLTICAKAPMEYAVEMFGKLGLRHLIVVEEGNSKVVGVIIKKRLVLYLEEIHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHP8</accession>
    <name>A0A3D8SHP8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_04161</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHP8"/>
    <dbReference type="OrthoDB" id="5835829at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016906">
        <property type="term" value="F:sterol 3-beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03784">
        <property type="entry name" value="GT1_Gtf-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000100">
        <property type="entry name" value="Glycosyltransferase family 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000009">
        <property type="entry name" value="Sterol 3-beta-glucosyltransferase UGT80A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010610">
        <property type="entry name" value="EryCIII-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050426">
        <property type="entry name" value="Glycosyltransferase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004276">
        <property type="entry name" value="GlycoTrans_28_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002213">
        <property type="entry name" value="UDP_glucos_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050:SF27">
        <property type="entry name" value="GLUCOSYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G04880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48050">
        <property type="entry name" value="STEROL 3-BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06722">
        <property type="entry name" value="EryCIII-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03033">
        <property type="entry name" value="Glyco_transf_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase family 28 N-terminal" evidence="3">
        <location>
            <begin position="146"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Erythromycin biosynthesis protein CIII-like C-terminal" evidence="4">
        <location>
            <begin position="454"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW85836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="856" mass="94008" checksum="A1A3B5A94A4D1BFC" modified="2019-01-16" version="1">MSDEKETVRQSSYNSAAPSIHSESLYSASTNLRRTVSYSSIGEDTTPGPSSRSTTFEFDPEDDDSVKTPSTIDWEQPPAYEINLTGRGGNVSAEVQKNGRISMIFDSLAKIPDIPAAGLEKLPEEDFKKTEQAPEYSHSAHPNLSIVVQVVGSRGDVQPFIALGKELQKSGHRIRIATHDVFADFVRDSGLEFFPVGGDPEQLMAYMVKNPGIMPKLATIRAGEITKKRKMVYEMLEGFWKSCVQPDPRTNRPFVAEAIIANPPSFAHIHCAQALGVPLHMMFTMPWTPTRAFPHPLANVQRSDNTAPQTSNYLSYGLVEMMTWQGLSDVINLWRRKVLHLDPIRAFMGAGLAEYLKIPFTYCWSPALVPKPRDWPRYVDVCGFFFRDSPAYTPPAYIADFLKAGPAPIYVGFGSIVMDNADEVTRMILSATDQNGVRAIVSRGWSKLGSKIPVEDVPVNVLFIDDCPHEWLFQHVTMVMHHGGAGTTACGLRNGRPTSIIPFFGDQPFWANMVAAAGAGPRPIEHKALTIERLVEAIQTCLTPKASEAANIIALKMSREDGVKQAVKSFHQNLPINAMTCDILPRHSAVWRYKTDKTFLKLSDKAAFILMEQRRIDIKNMKRYQSKPIAIEEKRWEPLSAGSSALLSAVVDVANDSADMVSRPIQELRKASTLRKGGSEAGSRSSEARHAFRDGLVNVGDSFAKGMIGVPVAMADGFHAIPRYYGEKTTKRAAVTDWKSGAVVATKGLRLGFFNGFTGIVTQPIKGAIDDGFKGFGKGFVAGSLGVVVKPGAAMLGLVGYSLLGAYKSISALHATPAEAKILLARQIQGSELARQIKKDDVEREMIIREFDARTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHZ0</accession>
    <name>A0A3D8SHZ0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HpcH/HpaI aldolase/citrate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_04116</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HpcH/HpaI aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHZ0"/>
    <dbReference type="OrthoDB" id="1621678at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="4">
        <location>
            <begin position="27"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW85791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="274" mass="28909" checksum="D5FAC68BDA2355DC" modified="2019-01-16" version="1">MASTMQEANRLRRAMEQGPSIGVWQMIPGANVSRTLARTGVDWVLVDCEHGNIDDAAMHDAVPAIAACGVSPIVRIPDNQGFMVKRALDAGAHGVLVPLLYTVEDARKLVLSSKFPPHGQRGFGSPFPQERFHPSLGASDYLAQANDAILTMVQIETKEALDNVDEIAAVPGIDVLFVGPFDLGNNIGHPIIDGKMHDSLHAAIAKVLKAAQAAGKKAGIFCTSGEQSKTYADQGFHMISAATDMHVLPAGVMNAVSTAKGQGPAPKLTGPYGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHZ7</accession>
    <name>A0A3D8SHZ7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04284</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHZ7"/>
    <dbReference type="OrthoDB" id="2823490at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW85959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="318" mass="36189" checksum="7AE9CD0640621A1B" modified="2019-01-16" version="1">MAPFPVEHLSHHSRIQGGAHSEATLMTIPREVRNRILEEVLLHPMIALPELNNVGDLLKERIEIPPQGLKAWTTKDAKFPHSPCRIHPIFLVNRQLNEEASATAELLPPNYILDVILFQEVYLLPTWIVMPKLIQSADTLTCNFRIAGSCEGPVQGYSRFGGGDGAGPISWIIYSLFERFIYYGPWWTAAGREAEHKLFIMRQLEVNIMTPPGLLPESSGPPQSSGNPHRGKNKDATVLSPMYLFDFIRQYFWTLLNMQNNWANYGHLLYENIGRIVFKLDGEVKSDIDMAEVLDDYEDADLEFKSFAQCHNDARVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SM51</accession>
    <name>A0A3D8SM51_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glutamine synthetase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_02955</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SM51"/>
    <dbReference type="OrthoDB" id="3364440at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43383:SF2">
        <property type="entry name" value="AMIDOHYDROLASE 2 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43383">
        <property type="entry name" value="NODULIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS catalytic" evidence="4">
        <location>
            <begin position="523"/>
            <end position="851"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00021364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW87261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="851" mass="94708" checksum="CA3C3570B6E1E0F8" modified="2019-01-16" version="1">MDDLIRAIRTTPIIDNHAHPLLIPSQHGKYDLLAITTEAGGEALKHTPSSLAHLRAVRQLAEILHCPATWQDVLQAIDGEKVKPGDAWAKRCLEGIETILVDDGLDGREEVFDYAWHDRLTRSPCKRIVRIEKVAQEILDEDLSQSDIPEVVAAFPRRFGEALDEAIRDQEVVGFKSVICYRSGLDIPPKPSLKEFSKELQGTLQELRATGVSGFKRLDYRPLNAWVVHTAAECISDAAVKKPLQFHTGLGDNDISLNTSSPSHLQEFIRAHPTLPIVLLHSSYPWTQEAGYLASVYENVYADIGEVFPMISKDGQERIVREILEFCPSEKILWSTDGHWFPETYILAVIQIREALEAVLSSYVADNALTVRQAIRIVEDILFNTSNKIYDLKLPLQPMHSNLVTASSAEVSDLALVKSFLKAHPAVKFLRLQYLDYTATLRLRIIPVKKVLSQLEKGFVFVGITKACLGLLQNDHIVPGITATGEYELRADFSSLRAGPSLEYACVQGDFHDADGSAVDLCPRSVLKRILVQAKQHKLEFLVGFEIEIVFMSPNPDTDLKYSLLPNSAGHAWSSSNSLKDKRVLRILSEILSTLQIAGIDLEQFHPEGAIGQYEFVLPPLPALDAIDQLLHAREIIVSIAAQHGLRATMVPKPFPECPGTACHAHMSITGGENKEAYEPFYAGVLKHLEAITAFTYSNMTSYERVLDGCWAGGRWITWGTNNKETPLRQAKGSHWEIRCLDGLANMYLTMSAIIAAGLLGVMDKEKMSWKDCQADPASLSPKEKQELGITTAFPESLTKALSALKGEDAAFTELIGADVVARYCLVKERESALLEAMTRTERMRWVIDRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SNI7</accession>
    <name>A0A3D8SNI7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_03583</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SNI7"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="533"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="44"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW87889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="654" mass="75357" checksum="3AB562272224624A" modified="2019-01-16" version="1">MDSRYSRSSYQYEHLLDGQIRLFEVHGQTIRTVEHVFLADNPSYEALSYCWGDPRPTEKLPCGDGRYIEVTKNLQAALRNLAHTEIPHDAPRRLVWADAICINQQDIGEKNVQVGMMREIYRHAQAVQIWVGEEEEDDDKGFDLLRRLLHVSSSRTASQHTHSISYMTPRTRATFLGLGDTWKDAFYIESGIVALLKMVDRPWFRRIWIVQEVGVARKAWLNCGKLSIEWEDFIQAIRYSIDVRVRPLEGYGREMALKIAQTRDTRQGFQISQTTENQGENLLSLLSRFHDFEATNPLDMIYALLGLTSSSTGITPSDIRVKVDYGLRKDEVYTQVARTILSKIGNLDILSACHLVPNESNDWELSLNQPSWVPNWSSSGKHITLRLQGSWREDYFDFAASGFHTRCVPKFPNNRTLCLNGILFDKVTAVSLPAETRRAPPDETPGIVVIFTDWFKEMYRTHLMFRSIDRMFDFGRHKAKYVTGESMFDVYWQTRICGCYGPEGYDVLYDYFHDKAKEGNWRHFPPPLIPRSLAPGFWIFSLAYIVSLIWLLVRGLFGVKRKPAEVDTLLSGKQEHMAYGLWRFIKTERGYLGLAPASTRLGDWIGIFEGGKVPLILRRTENLQAWHIIGESYVHGIMRGEAFDEKNCIEMNIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SNK8</accession>
    <name>A0A3D8SNK8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SNK8"/>
    <dbReference type="OrthoDB" id="5362512at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="205"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW87876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="880" mass="99680" checksum="6A75356CB7049FCA" modified="2019-01-16" version="1">MLCDRCQPIFEKPKFSKYTTFSFSKLAATSDFETHHPDFRSYEEAVHLKCLFCCRLRSILQAKAKLYLKDGNLDPAVDISSVTIEYRMAFETPRRTVVGFCSIVKFTKSGKGVREKVHQYMFLAEEQQPLTIHHEVSAWNGTDTSSMEIISNWVSGCLQKHPLCQRDKLPRQNRKLGRILDVGNTFDSPTIRLRSMEDLPEATTYMTLSHCWGGATIPVLTLDNYEQYRVSIKVEELPLTFRNALELTRHLRVQYLWIDSLCIIQDSADDWLEQAGLMDRIYQGSFCNIAATASPDPYGGLFSERDPALITPLRVQLKGVSPHNQDAFYDVGDDFSQEWMRQVALSPLAVRGWVVQERLLSPRVIHFAKKQLFWECAQMRTCEGSTVAGIDQSGFRHEMVDFKKWDPFSYDDLHVPSADPPPLGVEYVWSSVKALLGRDSRQFSRGVLTSDIEALEQAKKACFGEDTWTRTHPLLLYWANIIVTYGNAKLTQIDDRFIAIGGLAKILTLRTGVRYVAGHWLHQLPRQLLWTPKGMIAQSQSDKYIAPSWSWASQPVAPLSNMQLDRLLEDEGAMDLVKILGVEIEGARSEENPVGRLKSAELHIRGRLLPIQLDLTEWPKPLRKEGLVVPFFQPSVYDAPKAETFLVPLIFITGHKQVPVPVPNALLLEFLGQKGTYRRIGTARLSDIYDLRYTIPNLATIKTSDYEDAEFDTESGEETIFKAQAASKSIGHENNGRVPAGGLTPREEFHQVLMRSVSNPLLQSTLDKMVKHVSTKTSGKLLPQLTQYQALLDKHFVQSSNQKGIVLDKAMKEKIRVGSQKAFADSGLPDVHVEVTQGRNKLPEHDTKYRPKGSIAPMYYLNAIEDKDSTTYGDFVFKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SX60</accession>
    <name>A0A3D8SX60_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_02082</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW90917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SX60"/>
    <dbReference type="OrthoDB" id="648861at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW90917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="207" mass="22968" checksum="0F7F5738C306B55E" modified="2019-01-16" version="1">MVEDCTVNNLLNHQGVYTSWQGDLDYAESPSSRHAKTSQGIRLTVDIDKIAAAGEPVHSSFSYFVEVVDPPFISPFDDTNWRRIKAHIKELGKREGVIAKSIVAIEALHRAVTDRLPMAYAISAYDDAGTKFDSTFSNNIVDFDVILIVAFLLCLFKLTLPNEGSPTFDAPSGIFITRLEAWLRENHQSSIYIVANLCLVTAFGHGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SX75</accession>
    <name>A0A3D8SX75_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02087</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW90922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SX75"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF11">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW90922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="581" mass="65740" checksum="A3C4CC11FCCE4B8F" modified="2019-01-16" version="1">MPHIPDLQPVTDDAVRPSVVHPRGEPQPPISSAVWTSDASTSYQLDAKCQDFVTRYLGRSLITPDDPNMREVNRNLLILTFTHPFLMHASLAVALAYDRYLNSSSGGGRTIEECYHWSQSAALFHRRLREPIETKDKDPIWGTAAALTVLAFAFPDACTPEESWPLKPSEPSDLEWLRMEKGKMSLWHIANPLRPDSLFRVMSSTFAQMHSPLPEEGIDGIPRALAIVCHLENSSTVENNPYFTAAHALSQIQDLPDSQVTTGHTQLFTRCMHGPFNSLLRDKDPVALLLLYLWYLKVGRSIWWIELRARVECPSICSYLQLYHKGYVAVQVFLPGGPLADRWSQLDLQSLDLLPYPKLQFMAEAVTLHMQLLLRRPPHRNKNNPVPPWDDFDLMEVITSLLQKSLQKQAEDIYAGWVWFAYPKWYVLAILLVELCSCKAVDFSDRAYSVAQASFDQYAPLMSETDSGMFWRPITKLMQRVPMLRRVAIPAGFHHQSMGGIAEVEFSNTSIEDNILDSSSFSNQTQEANNQMIPESTIDTGSASIDEFARGSENNLETDDGMAWINWDLFLNDLSGSADMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXV9</accession>
    <name>A0A3D8SXV9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative alcohol dehydrogenase-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02279</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SXV9"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052585">
        <property type="entry name" value="Lipid_raft_assoc_Zn_ADH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482">
        <property type="entry name" value="PROTEIN AST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43482:SF1">
        <property type="entry name" value="PROTEIN AST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="15"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="323" mass="34558" checksum="5E241EEF2BF47FE6" modified="2019-01-16" version="1">MATMKAIKLVRESPELAPKILLETVAKPELIDNHVLVKVYASAVHPSDVLNALGGFGITKFPRIPGRDFSGVITEGPPDRIGEEVYGTSGFTHAFSQDGFHAEYCLVHEDAVVPKPKNLSFTQAACIGVPFTTAALTLRKARATASDTVMVLGASGAVGSAVVQLAKSHCCRVIKVSRSDESDINSAKDPELASAASLTENHGVDVVVDTVGQPGLTSNAVKRLAQGGRLAFIAAPRSGSTELSVDMLQFYRDEKTLVGCNSLKYSVQEMAAQMKAMKEHFENGHLKGAVEGEWTAVKLENAVGAYENAINKRSREKYVIVMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYD5</accession>
    <name>A0A3D8SYD5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Oxidoreductase-8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_02498</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYD5"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009688">
        <property type="term" value="P:abscisic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107">
        <property type="entry name" value="NADPH-DEPENDENT ALDEHYDE REDUCTASE-LIKE PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48107:SF26">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT-CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_4G05870)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW91333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="312" mass="33664" checksum="95A329600E5E20CB" modified="2019-01-16" version="1">MEAAKDTIKSAMGSGEQKSQFEKGHSVPVSNQDAPGKQHEMEGPDPVNDQLPTASGGYQPYRAAGKLVGKKALITGGDSGIGRAIAILYAMEGAESTIVYTPEEEKDAQETLKLVQEKGGKLHLQSADLRSQQTCKKVVAKAVEVMGRVNILVLNHGFQMMKETIDELSEEQWINTFDINIHPFFFLSKYTLPQMQSGDTIITCASVNPYIGRPDLLDYTSTKGAIVAFTRALSNQQIEKGIRVNAVCPGPIWTPLIPATMNEKAQKEFTSPMGRPGQPSEVATCFVFLASADSSFMSGQSLHPNGGVIVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYS0</accession>
    <name>A0A3D8SYS0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_02595</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYS0"/>
    <dbReference type="OrthoDB" id="2327445at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009571">
        <property type="entry name" value="SUR7/Rim9-like_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052413">
        <property type="entry name" value="SUR7_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28019:SF2">
        <property type="entry name" value="CELL MEMBRANE PROTEIN YLR413W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06687">
        <property type="entry name" value="SUR7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="220"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="265"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="11"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW91430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="339" mass="37139" checksum="0472D8853B4B81FB" modified="2019-01-16" version="1">MVAMPSFRSLRAGGRNKEDTSRAPATIRSSSDRTLTPTDGSFVQGVDLKRATQTRHRAILVSSFLYALSTIFLILTIIGNINKKPVIRSTYFFKLDLTNLIPASTPADITFVNSLARSLGLHDFYQVGLWNFCEGYNGEGITKCSTPQGLYWFNPVEILLNELLAGATIALPANINNILNLIKIASHLMFGFFLTGVCTNFLSIFIAPICIYSRWISLPFVIFTFISALLTAAAAIIATVMFSIFKNVITAQAGLNIGASLGTQMLAFMWIGAGSSVIAWVIHLCLLCCCATRRDVKQGRKRGSKYAYGNAATDEKKRPVRKRIVLPKFGRGSTSAEIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T038</accession>
    <name>A0A3D8T038_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative acyl-CoA dehydrogenase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_01284</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T038"/>
    <dbReference type="OrthoDB" id="435240at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00567">
        <property type="entry name" value="ACAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.10:FF:000012">
        <property type="entry name" value="Acyl-CoA dehydrogenase fadE12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.110.10:FF:000014">
        <property type="entry name" value="Probable acyl-CoA dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.540.10">
        <property type="entry name" value="Acyl-CoA dehydrogenase/oxidase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006091">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037069">
        <property type="entry name" value="AcylCoA_DH/ox_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43884:SF12">
        <property type="entry name" value="ISOVALERYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02770">
        <property type="entry name" value="Acyl-CoA_dh_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0274">FAD</keyword>
    <keyword evidence="3 5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA oxidase/dehydrogenase middle" evidence="7">
        <location>
            <begin position="41"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="6">
        <location>
            <begin position="153"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW91890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="316" mass="34832" checksum="0ADB83F6D143C85A" modified="2019-01-16" version="1">MAGAQSIHANVYATQPVAKFATAEQRQRMLPDLISGRSRACFGVTEPNTGLETLKLRTSATRYGDEYRISGQKIWISSAQVATKMILLARTTPLDEVKKLSEGLSLFFIDFDKTKPGLDLKRIKKMGGRAIDANEVFFDNYIIPGNSLIGEEGQGFKIVLHGMNAERCLLAGEALGLGYAALYRASQYAKERIVFNRPIGMNQGIQHPLADAYMHLEAAKLATYHAARLYDRSTIDEAVTQQAVGIACNSAIYLAAEAAFTACERSVLALGGMGYAAEYHVERYLRECFVPRIAPVSREMIMNYVGEKVLGLPRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0X5</accession>
    <name>A0A3D8T0X5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phosphoribulokinase/uridine kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_01475</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0X5"/>
    <dbReference type="OrthoDB" id="347435at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW92081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="22116" checksum="5B6B52198D2D5687" modified="2019-01-16" version="1">MNLARDFFTALKTSQPTKIPQYDKSAYNGQGDRVPREAWKSVNSTDQEPIRVIIFEGWSVGFRALSDAEVGAKHAAPGTVTLGKHRLEDLLFVNERLREYDVMTDCFDAFIHVDAEETGFVYDWRLQQEAALRREKGTGMSDEQVVKFVDGYYPAYELYTEQLRQGVLAGKGTEGRQLRLVVGKDRKVNQVFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T6W9</accession>
    <name>A0A3D8T6W9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Pectinesterase</fullName>
            <ecNumber evidence="4 11">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_00033</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in maceration and soft-rotting of plant tissue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1-&gt;4)-alpha-D-galacturonosyl](n) + n methanol + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22380"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14573"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:140522"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pectinesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="4 11"/>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T6W9"/>
    <dbReference type="OrthoDB" id="2019149at2759"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000014">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033131">
        <property type="entry name" value="Pectinesterase_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF127">
        <property type="entry name" value="PECTINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00503">
        <property type="entry name" value="PECTINESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017497906" description="Pectinesterase" evidence="11">
        <location>
            <begin position="17"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="12">
        <location>
            <begin position="33"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW94270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="325" mass="33928" checksum="39C31635FD8EBE36" modified="2019-01-16" version="1">MHTALAFLALVSSALAASRTTAPAGAITVGQGATYTTLQAAINSLSTSATTAQSIFILAGTYKEQVTIPARKAALTIYGYTTDDTDYSKNQVSIEHSCSQSGCASTNDGTATLSNHAAATKFYNINIKNTYGAGSQAVALSAYATQQGYYGVGLYGYQDTLLAQTGKQVYAKCFIQGATDFIFGQYAVAWIDGSKLSVNGNGYITASGRSTNDASYYVINKSNVVADASGTAKAGGVYLGRPWRNYARVCFQNTALSSIINSAGWSVWSSSDPRTDSVTFQEYGNTGSGASGTRASFATKLSSALTIGTILGSDYASWVDTAYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T707</accession>
    <name>A0A3D8T707_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_00073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T707"/>
    <dbReference type="OrthoDB" id="5425061at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018555">
        <property type="entry name" value="C630.06c-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09428">
        <property type="entry name" value="DUF2011"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW94310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="291" mass="33002" checksum="AEE7213D7450B5B4" modified="2019-01-16" version="1">MFDLPEAKRVRRSDLYTHSRSSSASPSPPDPSLVAKFQNQLAQIYGIVPPTAPLSPEDGAPGPSADTEEMHDAEDAQDDDQGFEFRLFSSAKPAEKDNPQTHKIVITDEDADWGDGAFVVPHRELSYYIIPKAEGDRRRGIELMAMSGEDILREKSRRHWGLEVPWRVKVLKVQGTVKKRGVERIVTMDQDAEEMAKRKKPGKKRRIILRERKKIKDEAEQKRKIAMEMKEEAEKEKRIRRNREKKIKRRLKEKAEKAKKAGLGDVNTDADGDAQSDASMDGMDVSLAAED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7A7</accession>
    <name>A0A3D8T7A7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein-15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_00182</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ornithine cyclodeaminase/mu-crystallin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7A7"/>
    <dbReference type="OrthoDB" id="41492at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000577">
        <property type="entry name" value="Proline utilization protein PrnX, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003462">
        <property type="entry name" value="ODC_Mu_crystall"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13812:SF19">
        <property type="entry name" value="KETIMINE REDUCTASE MU-CRYSTALLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02423">
        <property type="entry name" value="OCD_Mu_crystall"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="377"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="386"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW94419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="478" mass="51579" checksum="462BB52046927F59" modified="2019-01-16" version="1">MPLTVLSDANIKSLLQDLTQEDLFAFQQSLRSALYEYSTGTQDEGCCSLHQPKRTALTSGNGTTTLFMPSTSSGGIGMKVVTLATPGSEKASTGQTCPQGALTLMDTSGTPFGFLNAEEVTAFRTALASSLLVARRRNVKTLTVYGAGKQAFWHVRLALLLRGSTIKTVNFINRTFSDRARDLLKGFYAIDMQIKESEGWATTKFGMLTPGYGEFSRLEKDHLRAADIIFTTTPSTDPLFDPTILTNTEGRKKGRLIIAIGSYKPNMIELPTELLTQATKVHGSGHHFHKHAEEGGVVVVDTLDACLKEAGEIIQSGLSPQQLVEIGELVMLQDESQSSSSSLDLSDSPVESFSKLDLQPENGGKSLAHVFRENSMESARTGSTMSNGSRSVSRKSSFSGSHSRSGSFLGLGKKSGSVFSNNSKEKAQTSEEDKMSRWLCHGNVIYKSVGMGLMDLIVGADLVRLANEKGVGVTIDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T833</accession>
    <name>A0A3D8T833_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Putative DNA repair protein rad-5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BP5796_00480</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T833"/>
    <dbReference type="OrthoDB" id="2801544at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16572">
        <property type="entry name" value="RING-HC_SpRad8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014905">
        <property type="entry name" value="HIRAN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF22">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08797">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24975">
        <property type="entry name" value="UBA_Rad5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00910">
        <property type="entry name" value="HIRAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="511"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="902"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="988"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="135"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="383"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDW94717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1154" mass="128606" checksum="DD7A6F1EA59230C5" modified="2019-01-16" version="1">MDFTDFDGPPAKKRRFFTEDLERAEPSLTGENGLPIEVDAFSTKLPRTITNKDVDSNELIEDLGAQAAGEYVTDTSAAEENATPGFNPETFEAFVGVKVPPDVLKRLREASGDNLDRAVNMYLDGSWKSIAVTTGTSRNGLPARPLSMDAFTKPSPTDGSKTTSAKPASPPPKPQRRHAMPSYRYIGAFGVGGWATRSGALIKHGEAVHIERQKIQPPKPSVTKGKGRLVAVTPPKPNSAAAKRVDIIVRFTNARGDEIGRLPKETANWVSTLMDQKVCKFEGTCVYAPERIRTNDTIFLQLRCSLLKTAFDDRAFKVADNRKTGLWEEKESGEEKELRLRQVSLVKLFEEINLLPSRTSETTAKHKREGLLQAAEVAEQYEKEEAKKAKVEANGGSSPPSEDAEDGKELEQDQLDSLYRKAQSFDFNAPEAEPAESFAMNLRPYQKQALHWMMSKEKNERDESKEMSMHPLWEEYSWPNRDMDDKELPGVVDQEKFYVNPYSGELSLDFPVQEQHCLGGILADEMGLGKTIEMMSLIHSHRSEISNRLQVTSIPTSVNSLPRLPVNSSAVERAPCTTLVIAPMSLLAQWQSEAENASKDGTMKSIVYYGNDKTANLQALCCEANAASAPNVIVTSYGVVLSEFNQVAAKGGDRGSHGGLFSLNFFRIILDEAHHIKNRQSKTAKACYELAAEHRWVLTGTPIVNRLEDLFSLVHFLRVEPWSNFSFWKTFITVPFESKDFMRALDVVQTVLEPLVLRRTKDMKTPTGEALVPLPKKTISIVDIELSKPEREVYDHIFTRAKRTFAANVEAGTVMKAYTSIFAQILRLRQSCCHPILTRNRNIVADEEEAAVAADAANGLADDMDLESLIERFTAATDDEADFNAFGAHVLEQIRDEADNECPICSEEPMIEQTVTGCWHSACKKCLLDYMSHQTDKGEVPRCFNCREIINSRDIFEVVKDEGHPTIDGKPKISLQRLGSNSSAKISALLSHLKALRISKPGTKVVVFSQFTSFLSLIEPALTRASLPFLRLDGSMAHKARTAVLSEFASGKKGVVLLLSLRAGGVGLNLTMAKRVYMMDPWWSFAVEAQAIDRVHRMGQTDEVEVCRFIVKESVEERMLKIQDRKKFIASSLGMMSDEEKKMQSIEDIRELLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T891</accession>
    <name>A0A3D8T891_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_00497</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T891"/>
    <dbReference type="OrthoDB" id="3509960at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW94734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="294" mass="32758" checksum="579F4FB1891C8C77" modified="2019-01-16" version="1">MAWLSGSGGHLHGRNGSYSRAQLYGGAGGAPYGAPIRTSNVSNISHRSALPRASQEAHAANLCSTSNPLMPWGRGNGMAHPSTIGRWRGGLTPSYNINTGGQVPAPAPTYAVRNLDKKDIVIRDKTHAVRRSYLEEHPKFEKEIVGYMADKTEDNIPESVVDHLINYINNDFYANADLLDEVCLYLLSSAVNVSSVNAVALRNLVNWDWTGFWDWDGFTYAVLTILTSDNSNEAIRDWLKDVITTKLAYQHQNERIIRQKFNSDPIKTDHPEALIRFEQLVHGKKPALAKYRRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8H4</accession>
    <name>A0A3D8T8H4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_00590</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8H4"/>
    <dbReference type="OrthoDB" id="10018191at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000343">
        <property type="entry name" value="C2H2 transcription factor (AmdX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000576">
        <property type="entry name" value="C2H2 transcription factor (AmdX)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF13">
        <property type="entry name" value="RESPIRATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="58"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="9">
        <location>
            <begin position="86"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="108"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="779"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="924"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="782"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="793"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="951"/>
            <end position="974"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW94827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1156" mass="125999" checksum="4FC0C22D1A6320E0" modified="2019-01-16" version="1">MLNDPSALQSQPPVMPTATSSAAAGANGGMKKEETGPATNGKSSSSFPPPKTDKPRPHVCGTCQRSFARLEHLKRHERSHTKEKPFECPECARCFARRDLLLRHQQKLHMTTTPSSRPRNRRESAASSTAAGRVRKGSVASSAGPSAMRPRANTISHVDGAHMQLMAATNTAAAARGTMPPTHSRHPSLAGLPMQNYEHFGGMSTVMGQRGANHGLPKLETNSFNNIDYSGGLRTAPVNGGFNGNDFDFEGLLFGPTSTTINPNALHYSDSPQSMAIDAASPYHQAFPDMSASQALDENFDWMTGFEHQMSFNGPNESAIDGSSPSAISTASQSGISEVMLDGSNNPAAATTGAMWQSSMMAPPLMTPNPFTLDLGHSGFPDLMSGPLSPHSLPQKHANDPYFSTPPPSMSSLSPSVMPGLTTQGLHQTMNFGPETPVSMNGSMHTSLPLASITESTRQALLAALAQCAPFGGRKYSFTATSSPLSPHFSGRTSSASETTRTLPSTFDLQRYVGAYIRHFHPHLPFLHISTLSFDVSGYSNNGHNAGLVGGRGCLILSMAAIGALYELEPVQSKELFDSAKKMIQLYLEERRKEDVRKADHRRPSITSHGTRSTDNSVHTPVWLVQAMLLNVVYGHNCGDKTAGDIASTHCAALVSLARAAELLRPQQSSQQDVSMTDEETDWDKVDVSDDQYEWLKWKTMEERKRTLYAVFILSSLLVSAYNHTPALTNSEIMLDLPCDEEFWAAESASSFRAKGGARMADHNQITLHDALGELLRTSEKQQQQQLHMQQQFGSSVNSTELPKSDLRPSTFGCLVLINALHNYIWETRQRHHNKIWTNEETEKMHRHIEPALKAWQAAWASNPQHSLERPNPFGLGPLSADSIPLLDLAYVRLFVNLSRSKEKFWQRDFDGMAEELSRGSEIVQHAEHSPGSDDSADPSSGTSSVFVDTPPTSNSSTEFKISNSGNQANSGATSKRERHLRKAAFYAADSLSMSDKLGVTFADFTSRELPLQSAMCAFDCAQVLAEWIATVQERVGRYLGILGKDDIDLSQVPGIMLLEEEDCKLLAKIQEVLNSAEIKMNYDLQGMGAVASMAAAAQRLPGGDNSGYGSKILRVTAYMLDKAAVWPVTHLMARSLEIQASHMRARAEDSVAQRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8J8</accession>
    <name>A0A3D8T8J8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_00656</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006093">
        <property type="entry name" value="Oxy_OxRdtase_FAD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660:SF2">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47660">
        <property type="entry name" value="TRANSCRIPTION FACTOR WITH C2H2 AND ZN(2)-CYS(6) DNA BINDING DOMAIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00862">
        <property type="entry name" value="OX2_COVAL_FAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="9">
        <location>
            <begin position="988"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW94893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1417" mass="159140" checksum="3CDCE3987D4886B7" modified="2019-01-16" version="1">MSMSGRNNMYHYPDPQQQNIPGQIPGMDTFTQHSGSIPISEPTGSIDESMINMASTTLVNDPMLDMDMDDSSLADFLRDIMMPPSPNHMIDEAAIEFIPQNYSSRDVLNFGFDSSLDFNDMDYGWMSSQNNNISTVNFHMVPDHVDPPLDNGQQTPEVRNSIGLGAEAFQKSLWNWSPTQRDHVFNDTAALSLPYKDIESLEGRVESDILEHQLDQSSRDGILAMVLATHNRNVEHGMSRVVTSFPSAQLLNSLIHLFFRAESLKTDSWIHIPTFRPQSNRPEFNGIVVAAGAVLSSVPTVRKLGYGIQESVRLALPNLFEHDNSRTRELQILQAYALEIGIGLWSGNKRKMEIAESHAQPLITMLRRSGHFRRMRVPPSKPEVEDDEKTLESKWRAWIEAESWKRLAFHTLLHDAQTSISLLVRPLVSYAEVSLELPCSSALWRAKSPQAWREVYLQQPSISSRLPSLVNCVHDLTPILKAQDMIDLQHSTSIVLHAIWSLISEYRQLEFVLKLQSPDRHWNGALISTSWYQELCQLGDHFRISVSEWPGGMRPEQNMIQELFMMNLHVSFEELQLFAGKEGTEEAQRVYPLLKLWFETRKSRQAVWHAGQVVRAALCFPSNQLRDFYSVALYHASLALWVYGMISLASSRSRQRRGAPVDPPTENDVVYLDSVETAESRRFIAIGRGVPVIQELSPALPLQPRNQEQDKPGFARLDNPKAVMETVINILTRDCTAGKDAFSPLVENLGQLVRDLGNAARIQLLILYKTQWTDSCDTFLRLAQLREQLIRGRPASTEVRQCRLAPTTSNQLPIPSWYTIVTHNFLEIASKTSIGMWGRDAYAGFISVAAPLILPPQTEGGLWRIDETLIRGIVGSFSEVEFCFFGASRACYIGVRESYLLLGVAISRASRVFATSTLFPDPGYHPNPSQRLEAKSAIMLTQQTALVPEPKFQSPDATNIFQDTPVIWPSSPDYERARVGRVFNHRRPSRYPRGVIEATTVQDIINGVHLANQEGIRVSVRSGGHSWAAWSVRDDAILIDLGKFKCIEYDEATHIVKASPSTTGRMLNGVLVPLGRMFGGGHCPDVGLGGFLLQGGMGWNCKNWGWACEKVIGVDVVTAEGKAIHCDKDQNSDLYWAARGSGPGFPAIVTAFYLETRESYTNMKSSTFVYPISEYKPVMDWVQKVSLECDSSIEAVAVGAIDPATKAPVIIAHLVTFQNTAAAAEASLRIFNESHPPNYLVESMNEDTSLAKEYSDQCGANPEGHRYVAENAYLQNDADVTEVLRKAMTTLPEGSKAFSLWFSMNPTSRRPLPDMALSMQSDHYFALYTVWEHETDDERCKAWVRSIMKEVEPHAVGAYLGDSDFQVRQTKFWSDEKAERLMAIRRQWDPQGTVCGFLDRGDQSRTKGLANVTEWQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9C9</accession>
    <name>A0A3D8T9C9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WW domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_00942</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9C9"/>
    <dbReference type="OrthoDB" id="4586300at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WW" evidence="3">
        <location>
            <begin position="174"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="485"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="485"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW95179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="530" mass="60092" checksum="8B4E5FE159D687C3" modified="2019-01-16" version="1">MTRANLGLAEKEREAQEAQKAEHAQDQCNNNPFIKFRQFADAKISSLLQGVIGLPSTFSRSPGDTHWADIDDDLRRRDELHSRQNALKIAEQRRRMQNEADGSQEVAISVKTSADWDSSITRREGTGIGNNTTEDWPLYSRVSKSLFGHLVSVGEDNVEWGQCHPLFDLPDDEDELPAGWERKVNPFGRTYFVDHNTRSTTWSAGAPYLYLLRPDQKSHDVSRMVQHMAFNNLNKTARASLPYWGGLSLHAGNSLLPYLLFSTYSPINLQRSSEEPAYRDAFEDLLAMHNGLPLRREGRGEDLAIKEIEQTAKDDDIDIAKKNMSWIYTLKARGILSQPNTPSEVATDFASSFLRPDIMSDILRPFRQSEPEDNDQNTEQDMYDHFLRSASSAASTSVGLVDSLFSDAERFIQDLTEGTRKDQDQPEDTKTATKTFYERTPAGEATKPSGDADRVVSTITSSEHITHEDGRVETNITVRRRFADGRETVTEKSHIEHPRNDVADRIDEIQQPTRSGKNPENENKGWFWKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9G2</accession>
    <name>A0A3D8T9G2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_00920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9G2"/>
    <dbReference type="OrthoDB" id="3989227at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="18"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="56"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="659"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW95157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="706" mass="79144" checksum="CC50AEC8532B54AC" modified="2019-01-16" version="1">MPPPERVRKITRNRQSLICARCRIRKVRCTREHPECSNCVKVGEICTYGAHVQERVEPPTSKPRLTESALDNTPKSISESSHSPAPNDISVPAADTALVASQEIRALIQTDEFLEDARFLNIQDHVPPPVHVSGHLNTRDPSRPKYLEATFWGLVGGQNYMRVSSFCPHSNLDEYVDVGGLLNTCKDLPERPICDILVRSFLIGVHSIYPLFEAASFCASYAHFWVWCGNGMTGELHHHLVNDQTFLALMISVLYCGAVTAPAELWISGLFKEQERLELIETLKSAHSAGLAMCQHIRHPTLHTLVALLLVHSCEDLDSDSLGDAHFVGLVLRMAQSLGLHREETFSGPKEELELRRRIWWHIVWLDVQVNIFSGTPLTFGSGCDQSSTAMPNHVPANDYLTDLGRILFFPSPSTELGHSSFVLFAIARYETARFEHSLFELIQGTRPLLQADLNSSLKQIKTLHSQLNDLAAQLYVEGIPERGFMASRIADASPTTHLSLYGDQSTESTVFSSWARIMITFLKAESAILLQKAFTSNSLFVNKKQVDNIWKRTVALCISCLRNFIQLVRTPSFSPYRWFLVTRLPPIQPVYLILVHLKRHPNSTEIQLARYFTNEIFQVFDSEKQGPLDPLYPHKPSSQVAQAWNMLKALHARIDSDPDFETPPDMGGSPSSTTPSLDISGLEAWSLSIVGPDDTLALPAYKKHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9M9</accession>
    <name>A0A3D8T9M9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BP5796_01023</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000019">
        <property type="entry name" value="Polyketide synthase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9 12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="30"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="16">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="17">
        <location>
            <begin position="165"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="18">
        <location>
            <begin position="1118"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="15">
        <location>
            <begin position="2478"/>
            <end position="2559"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="13">
        <location>
            <begin position="1118"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="13">
        <location>
            <begin position="1283"/>
            <end position="1440"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="13">
        <location>
            <position position="1150"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="13">
        <location>
            <position position="1348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RDW95260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2565" mass="282670" checksum="0C2D5C22990D0F80" modified="2019-01-16" version="1">MEFPNIFLNIQKFLDKNGLRTSMLRTYNRYVLLTTYLFGRLIPGIYFQALMSRDIFNALQQKDPKIPGTYLLQLTEQAHMESTALYSVPPLPAWLAIIQLSSISLLNLQGLYWFGKLLRSPHYTPVPSDPVPDKVATETFRHIQPGLVNEIQSSSTSKKTSKDSDMPIAIIGMGCRFAGEATGPDKLWEMISAGADAWSEIPASRFNQDAFFHPNGAREGSTNVRGAHFLKEDISLFDAPFFNITLEEAKAMDPQLRLQLECTYEALENAGLKLDSIANSDTSVYSGIFARDYHESLFRDIETLPRYFNTGNGAAMFSNRISYFFDLKGPSMTVDTGCSTSIVALHLACQSLKSGESKMSIIGGNNLMLNPDMITAMSSFGFVSPDGRSYAFDHRASGYGRGEGVASIIIKPLEDALKDGDNIRAVLVQTSLNQDGKTNGITLPSQSAQENLIKSCYNAAGLDPAETPYVEAHGTGTQAGDPLEAGAIASIFGKGRPAHKPIYIGSVKTNIGHLEAGSGLAGIVKATLVLEKGLIPPSVNFEEGNSKIPFSQWKLKMPQTLEQWPVGSPRRISVNSFGYGGTNGHVIMESLEQFLYRAPKISASRTSAIPQTGEIQSLVPTRRRLFTFSAKDQDATNSLVASLALYLKGRKSSGRNELLDNLAYTLSERRTVFPWSMSMTGASVEELINSLEDNKLKAVRRRENIRLGYVFTGQGSQWYAMGRELINAYPVFKETLLAADVHMRKIGASWSIMGKNQFSVMEIAANLGTDELNKDAKSSLVNEAVYSQPLCTALQVSLVNLLRSWDIIPTSVTSHSSGEVAAAYAAGALNLESAITVSYFRGLVTRNIQINSPGLKGSMIAVGLSREDAEAYIQRVASGKIVVGCINSPTSVTVSGDIGGIEEMQKLLEADSIFVRRLPVDAGYHSHHMEVIADDYRKLLQKHYLNTEKWSGKVTYSSSVTGSFVTDSDVFGREYWIHNMTRPVLFMDSLRNMVLGQPRSTAGAPDSTIDAILEIGPHSGLAGPIRQTFRLPELKDLTIPYVPCLIRKENAEKTMQEMACTLLGIGYRVDVSRLNFPGRKPELKVLPDLPSYPWSHKTRHWHESHLNRQHRLREGAPHDLLGVQATNSNPLSPTWRHIIRTSDIPWVRDHLIQGSIIYPAAGYICMAIEGFRQAFAKDSQDIAKYRLRDIEVLNAVLIPETTEGIELQLSLRPAADKLPSSQGWYQFHVHSVAPDQDDKWTEHCTGFISSDFRPRTDDSNWSTGLNLGEESSNTHQAAPSTFLKPYDTSKVYEMLKSDGIFHGKAFQNLEHVEVAPNKSLAAILIPDTASVMPYGFEHEHVIHPTTFDTVLQAIYPVLQMESAEAKKPTRLPRSFKSISVSTDIFSKPGSRLKATSVVDKISAKSVVSSISVTQDCDDISSSVMEIAGFRCETIGDAATETDNSEQTKLCFQMAWELDVELNGPETYETLDNNSQLGEFLRRYAHKYPGSRYLGLDSTNFIMSATIIDILGKASTENRPLPHFDIAYSQGDAEVSAAEMFKDHKTSIRMINFDTLRDPVEQELRVDTYDLVLMSRASEPTETLKLSFPNIRKLLKPNGRLIMTQGNGYSSKDQESLSTFLVKEGFTIDSVAPGFVTAVKYGSQSCLEEASEKLPISLIYGKTYPPGLWREAFESSLASALDTQPEIASFDGRNYTSKTIVVMAELVKPLLATLTAEEFLVLKSTLMSAKTVLWVTNGGAICCEAPECSLVTGLFRVLRAENSGTRYLTLDLDPLQDCFTSVTSASIISILKAAINSTALTMVIDWEYAQRDGRILIPRLVEDTNANKIFLSQEDSLVPQMEPFYQAGRPLMMKIGTPGLLDTLGFVDDATIVTSIPEDIVEIEPRAFGLNFRDIMVSMGHLDETVMGYECSGVITRTGKAVPQEYRIGDRVCVMMKGNYANLIRVPWETVGKIPEDMPFDVAASLPMVFCTAYYCLYNTARLQKGETILIHAAAGGVGQAAIMLARLLGAEIFVTVGTKEKRDFLIETYGINPDHIFSSRTTAFARQIMAATGQKGVDVILNCLAGEMLQETWNCVSMLGRFVEIGKRDIELNNHLEMAPFTRNVTFSSIDLTYVMKYKPSILSTILGDCMELFKSGLIHSVRPITTFSMSEIERAFRLMQSGKHRGKVVIEPCKEDTVKVYPHRSAARFEDNASYLIIGGLGGIGRSISRWMVSQGVKNLILLSRSGLTRRAARDFADELMGAGCNVSVFSCDIADENQLSKILRKCAVSMPPIRGVIQAAMALKACNLPCDISDSIFEQMSYDSYTEALDPKVKGTWNLHKQFLDGIDFFIMLSSAAGIGGNPGQANYAAGSTFLDAVARHRASKRMPGVTLDLGVIGDVGYVAENEELATRLNKLGHVFLKEKQLLSMIESAIIDPIRDPKSSQIVSGLGQENEGTPWSTDAKFSIFRQMASAGEAAYNKQNQESGLPAQLARVKTLQDAASLICKAIAGKLSQDFMIAEADINFEESLASYGVDSLVAVELRNWVSRQLKADISIFDVLQSKSLRTLAEKIALQSEFVKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9T5</accession>
    <name>A0A3D8T9T5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative NAD indole-3-acetaldehyde reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_01069</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9T5"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016652">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd19120">
        <property type="entry name" value="AKR_AKR3C2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000002">
        <property type="entry name" value="2,5-diketo-D-gluconic acid reductase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044494">
        <property type="entry name" value="AKR3C2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827">
        <property type="entry name" value="2,5-DIKETO-D-GLUCONIC ACID REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43827:SF3">
        <property type="entry name" value="NADP-DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="7">
        <location>
            <begin position="40"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="6">
        <location>
            <position position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW95306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="311" mass="34525" checksum="B1D67B6DD8EE9BCD" modified="2019-01-16" version="1">MNSTTATYNPSTDGVAPKQMSQLQNLKLNDGNEIPMLGYGLGTARSKSDHNAPLDKELIQTTIMAIKNGYYHLDGATFYGNEAELGEAIKQSGVPREKLYITTKISGTDVTDTEEDFALSLKKLQLDYIDQYLIHAPYFAKTPADLQKKWADMEAIKASGRAKSIGISNFLQKDIETILETAKVIPAINQIEFHPYLQHGGLLDFMRSKSIAASAYGPLTAVARTSGPLDPVYEELARKYGVTPGEIALRWVIDQGIVAITTSSKEDRLKAYLKVAQFKLTPKEVDQIKELGQQKHFRGFWNAKFADDDRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q360</accession>
    <name>A0A3D8Q360_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_13231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000029">
        <property type="protein sequence ID" value="RDW56356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q360"/>
    <dbReference type="OrthoDB" id="190201at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017811708" description="AB hydrolase-1 domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW56356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="404" mass="44207" checksum="B0ADA1F80791CB50" modified="2019-01-16" version="1">MPRLNNLYFWFSACLSYTRGSLASPTSDHFHGSTPYMTCATWTLPVAATADNVIFDVPHVDSDIDVPDYVWYEDTWSTPNLAARTRSTLHVDDTFGINVQLCMPTLDTKGKRQILQIATPGFGFDKRYWDVEVESDKYSYVRAAVKAGYSILTYDRLGTGLSDKPDAYNIVQAPLQVEILKSLTILARNGELTKAAEPHFAGGLAVSNFTKFVHIGHSFGSTVTNALQAQYPELSDGAIQTGWLVSEHLGTFGQAAFGYQYARQNDPIKFNDRGSGYIVTGTKNSFQQLFLAKALLDPKMLNYGNSIKQPGTVGEGAPTGPIIGIPAIDFKGPLQIFMGEHDFPICDGDCKGVYNVTELKKSSFPKASALEVYIQPGTGHGCALHKNATAGYQVMFDFLDSNGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q3Q5</accession>
    <name>A0A3D8Q3Q5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_13225</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000029">
        <property type="protein sequence ID" value="RDW56350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q3Q5"/>
    <dbReference type="OrthoDB" id="5428890at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="327"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW56350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="409" mass="45817" checksum="D066864A8FADF076" modified="2019-01-16" version="1">MAGTSILSPLSGELKRKILQSFWSIDAEDLEEYKWFFSYYEKKCKNLRSATGVEFTKLSGKNHEDIMKVIDIIWKSGENKTSVERPELRSILKTHEEFVLKGDSALNTSINVALRLWTTINFCEDADPDISPGSVEWNDTTKLNEFIASQFKPAPIRSPTTLSTQSTAQKTGTKMDGQFSAVALQSLHGIQTQVATNIVNHLLYEDSEENGRILQVFMSKPFLEAHKQSNTKIFPTALLTETLTTLGILFPSTSEREHKKTTKYVEKYHAEICDPTNNPFSTPGFEHPAISSFSYWQVRLDDIYKIYRSKPTSLWYRFKDFRDPEEWLSFWMGLVAILILTFVFGCISTATAIASVVYTYQGLVIAKEGLAIAKDAASSAVASASLASVSAAMSSGVAATTERLVRKQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q491</accession>
    <name>A0A3D8Q491_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_13114</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000025">
        <property type="protein sequence ID" value="RDW56649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q491"/>
    <dbReference type="OrthoDB" id="3903189at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW56649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="104" mass="11868" checksum="1FAFD062B220B375" modified="2019-01-16" version="1">MLLGLFSLGILTIIAATINKYYNFTDPYNFSTFIPWYIREISMAMLVANLVLCRPALRTIFHGFELPEWLHFGIHLKKALSSNADCQGSNTDRFESTGSIFSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q4Y9</accession>
    <name>A0A3D8Q4Y9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_12953</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000024">
        <property type="protein sequence ID" value="RDW56886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q4Y9"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF152">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW56886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="503" mass="56391" checksum="0BF12F04F8AB2BFE" modified="2019-01-16" version="1">MTDLVGSLGGLRIATIAILVLCVTSLTQRLLYNLYWHPLAHIPGPRLAAATYLYQTYFGLAGGKSRYYMHIAELHRRYGPVVRITPDEVHLSDPENHEVIHSVGSKYAKATPYYSALGAGYSTFTAGPNEVHKLRRARLDPFFSRRNVIKMEYLVQSRAAKLLHIMSSKFSAGAAVDLHHAFRSISVDVISDYAFGESYSLLDRDDLGREFFELTGGIGPTWWVFQQWPALQAFALSLPLSVAKAMSKPLKQQAHSQVLEVKAKLDAGQKVDKPCIFEALLEPADGYQIPTPDQIKDEAYAILNAASDTTGNAMTVTAYNVLSNPEIYRTLTEELKTAFPNKDQPLEFSKLEKLPYLTGAIKEGLRLSFGVPGRMPRVVPEPGAKFNDYYIPAGSFVSLSSWMLHQDEGYFPKPQKFDPTRWSDPKDSRRMEKAFVPFGKGTRACAGMNLAYCELYITLGTLFRHYDNLVPNHLTLEDLTYDDYFSAQIPLNAAKLHVHLDKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q575</accession>
    <name>A0A3D8Q575_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_12904</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000024">
        <property type="protein sequence ID" value="RDW56837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q575"/>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF12">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW56837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="30669" checksum="CCE7DC7B96994677" modified="2019-01-16" version="1">MINSITQIESLAPAQEVRALEYFIRKTAPALGGFFDVYFWTVQVPQLSQNDAAVRFALIAVASVHEQMETIRNILIGRTRADKDAIGAKQLLGFNQYNSAVGRIAAQICSGTRPVEVTLACCILFICFDFLRGNFTTALLHLRSSLRIAKALQEYAITTSMHSIFKENIFRTFEHLSFQLTATHKPSLGSKLDFPSWEAQQADDREFLDLSSANRSLDSLSRVIFTFAMRSGQLHQPSLPSEIRADLEEERRRLLNALLLWDLNSRPSLLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q670</accession>
    <name>A0A3D8Q670_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q670"/>
    <dbReference type="OrthoDB" id="10351992at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW57316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="81" mass="9325" checksum="FB130134F434F578" modified="2019-01-16" version="1">MSRGGNTKQDGKSTYMQLIAIQGSFHAPLANVHRTRSESMEVHRFSDEEMDYDTQGPPKEPRRDEKHNKMNKPGKINRKPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q900</accession>
    <name>A0A3D8Q900_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LysR family regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_12242</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Secondary metabolite biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q900"/>
    <dbReference type="OrthoDB" id="21502at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051283">
        <property type="entry name" value="Sec_Metabolite_Acyltrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31896:SF69">
        <property type="entry name" value="FAMILY REGULATORY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02458">
        <property type="entry name" value="Transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW58312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="493" mass="55734" checksum="4E3E9693F57BFA77" modified="2019-01-16" version="1">MTWFFRRKKPAVVPTDTIIPLHHFDDIPIFRRAIYDFTLRFDDVLNPDELSAALRRLMEIGNWRKLGARLRLNDQGKLEYHVPMAYDKERPGFSYSHVKHEGSIQNDPTAARIPKMTSNPSVQDSPEQFGCFVRRPDAPMKLHDYVLTDEPQLSLHVVSFADATLVSITWLHTSFDIMGQAALIDAWSLVLSGQEHRVIELHGYDFDPLATFGCSPISAEQSLLASHDVKGLHYILFALRFFSEILWWPKDELHTVCLPASYLHTMKEKALQELTTNETSKPFISDGDIICAWITRLSLQHLPSSSTRSVAITNVLDMRRFLSKDLLPQGTAYVSNAASLVQSLVPASQLFQKPLSFTALKVRQGIQEQATREQVEAFIAFQRENTTSSGDSTAPFGDSTSQLMLFTNWTKGNFYEVDFSSAVVKPGIPLEKRANRVGRPSYVQAVGHYDTKIPSRYAFIISGKDAAGNYWISGRLRTGTWRSIEKEFASARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QBH8</accession>
    <name>A0A3D8QBH8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_12127</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QBH8"/>
    <dbReference type="OrthoDB" id="2152029at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF31">
        <property type="entry name" value="STERYL ACETYL HYDROLASE MUG81-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="45"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW59203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="296" mass="32435" checksum="007788CFB1ECEED2" modified="2019-01-16" version="1">MEAPMVSTDETYKNVVAAEGLPVDVESLDGYKLCWLGPRTGKKVIVYACGGALVMHANNAHIQWLVNGYKAMKANGQDVSIAILAYGLCPDVPYPGPIRHMVGTVKHLLKSRAPETISFSGDSAGGLLIIATLLHHNHPHPNIESYDLPPTARFDETLLISPGGPVDTGAASLHQDPQTDVINFADLQHLWGIITSTVEPGLAMPNAWMAPSTAPEEWWKDLPIGKITIFLGDLEILRDDILKYGALLKKYHDKEVVIQDFPGEYHEQAIIDVIQGVPEEKGSAKAWKAWFQNFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QE65</accession>
    <name>A0A3D8QE65_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phenylalanine--tRNA ligase beta subunit</fullName>
            <ecNumber evidence="5">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Phenylalanyl-tRNA synthetase beta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BP5796_11607</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>tRNA(Phe) + L-phenylalanine + ATP = L-phenylalanyl-tRNA(Phe) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19413"/>
            <dbReference type="Rhea" id="RHEA-COMP:9668"/>
            <dbReference type="Rhea" id="RHEA-COMP:9699"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58095"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78531"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="5"/>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QE65"/>
    <dbReference type="OrthoDB" id="1698572at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00769">
        <property type="entry name" value="PheRS_beta_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.40.10:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000006">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.10:FF:000004">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000052">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040659">
        <property type="entry name" value="PhetRS_B1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF0">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18262">
        <property type="entry name" value="PhetRS_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56037">
        <property type="entry name" value="PheT/TilS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="17">
        <location>
            <begin position="297"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00049255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDW60001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="609" mass="68815" checksum="1D051438705C2F00" modified="2019-01-16" version="1">MPTISVDKAELYKALGQEYTTEQFEELCFDFGIELDEDTTDQERPIVNGKQEPAQLKIEIPANRYDMLCFEGIALMLNIFRGKLPLPNYRLVKPQGGKLESITVTKNTERVRPYVSAAILRNVSFTQESYNSFISLQDKLHQNLARQRTLVAIGTHDLDTIKGPFTYDALPPKEIAFIPLNQTKKMNGEDLMEFYANDKNLGKYLNIIKDKPVYPVIFDSENTVCSLPPIINGNHSKITLKTTNVFIEMTATDRTKLEIVNNIIVAMFSQYCAEEFTIEPVEIISEHNGESRITPDISPRSAEAEVDYINACTGLDESPERICELLTKMCYSAKPSSKDKNIIDVSIPPTRADVLHQCDIMEDVAIAYGFNNLPRSSYNKSSTVAQPLLMNKLGDIVRLESAMAGWTEVMPLILCSHDENFAWLNRKDDGNTAVKLANPKTAEYQIVRTSLLPGLLKTIRENKKHSVPIKVFEVSDVAFKDVTLERKSKNERHFAAAWYGKTSGFEIVHGLLDRVLLILKTAFVTHEEGLEGKKLQYDVKEDPSKPDGYWIEEINEPTFFSGHAAAIFLRLDGKAVRIGEFGILHPTVLDKFELRYPVSTLEINLEVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QEK2</accession>
    <name>A0A3D8QEK2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_11696</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QEK2"/>
    <dbReference type="OrthoDB" id="3163292at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF17">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="7">
        <location>
            <begin position="264"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="27"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="84"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW60090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="676" mass="75902" checksum="60123DDAA3EAC902" modified="2019-01-16" version="1">MKCRRDPASAICERCIRKSMDCVFEKHKRGRKPGTRLVRKTQDQLSPAGPSTQSRGANQLWHSETTSQNDESMIEPGLRDGASSHYSSVGQSAPSEKGIWDESNALQPAELLNKNAKTGKFSLQNVLSTANASDPEEQDDGAAHHTSPEGRYIQHLDDPIRCKILNFPIALGLFDSFMRSLNPFISQFDPSLHTFEYVQHRSPFLLTSILAAAARAFHPPLHSQLRAHTELLMAKAFTQGTKSAEIVQAILVSTYWKEPDDTRSWLLIGYAIRMCIELGWHKLPPTTAESLEGETELQIREARNARRTWLILYVYDRSISLQVGKPCMIEQNDFITTAQDWYQLPCAVFGADALLSAFVTLRILTSEIIELVSPDRTSRHIQQGDNLMKLLNASLTRWEEHWHPISEDERVDRCQSFLIKFYGTHLRLLLNSYSLQESLKASKDGTPISKQAVWTCYSAALDMLKQISDQFGPLKLLYFAQDSVHVMTAYSAVFLIKLLLSLPAHMSNEFEATSIEAIKKTAQTFEAQCATQKTGCALQARFLNNVAVQYEKAKQQTKRIPITQLQQEVKTENVQQYSEPTGANPTTNSQLDQNQMVQDVLPQQAAYSQTFVSGQGMAPTQENGYANNAGMGYETELSGWNFDNNDQWEAMFANAGYRIYDGVFMPEDAMAAGLEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QF34</accession>
    <name>A0A3D8QF34_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="14">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BP5796_11640</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP phosphatase family. PP-2B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="14"/>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QF34"/>
    <dbReference type="OrthoDB" id="5593063at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07416">
        <property type="entry name" value="MPP_PP2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041751">
        <property type="entry name" value="MPP_PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="6 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="16">
        <location>
            <begin position="187"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="519"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="422"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="519"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00053858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDW60034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="560" mass="63614" checksum="D4783B8C4D09FD2B" modified="2019-01-16" version="1">MDGEAPTTPTAVPGVEKAYVDNALRAISDKKPVPEIDFTLHTMEDGSQVSTQERVCKDVQAPAMHPPTDAQFFSPQDPSKPNLQFLKQHFYREGRLTEEQALFIIEEGTKVLKQEPNLLEMDAPITVCGDVHGQYYDLMKLFEVGGDPSETRYLFLGDYVDRGYFSIECVLYLWSLKIWYPNTLWLLRGNHECRHLTDYFTFKLECKHKYSEKIYDACMDSFCALPLAAVMNKQFLCIHGGLSPELHTLDDLKSIDRFREPPTHGLMCDILWADPLEEFGQEKTSEFFVHNHVRGCSYFFSYPAACNFLEKNNLLSIIRAHEAQDAGYRMYRKTRTTGFPSVMTIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCTPHPYWLPNFMDVFTWSLPFVGEKITDMLIAILSTCSDDELKEDGTPSTVSPPLASPQGSAMNMDPESIEFKRRAIKNKILAIGRLSRVFQVLREESERVTELKTASGGRLPQGTLMLGAEGIKNAISSFEDARKVDLQNERLPPSHEEVARQTEEGRTAALARASREADNDKGLQALSRRLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QHV9</accession>
    <name>A0A3D8QHV9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_11314</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QHV9"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="5">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="178"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW61422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="209" mass="22330" checksum="11E7E4184704E02F" modified="2019-01-16" version="1">MSSTVHISSANQFRTLLSSSTIVVTDFYADWCGPCKAIAPTFESLATKHSKPNRVSFAKVNVDNQQQISQQYGVTAMPTFLIFRSGSVIETIKGADARKLTSAIENAVKLAGAAKPAYSSVGRTLGGAPSTRSSMTRPWNFKGFVDAIIAFFGLYFISLFTFDAYTAAENSPFNIHRVPTASQPAGRTAGAKKPVPPPAKKLGTLADLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QI00</accession>
    <name>A0A3D8QI00_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">OPT oligopeptide transporter-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_11233</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QI00"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="343"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="422"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="504"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="591"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="667"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="713"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="746"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW61341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="798" mass="90428" checksum="BA11A472FCA63B46" modified="2019-01-16" version="1">MDPISAPELVADTSSTDEKHPYDEKKTSIDIEVNDLDLAADPYDDAAKIYVPDEHEEFIDPRLKDYPVPLVAKTVDLHNDFSEPILTFRFWVLSTFWLIVGCGISSFYYFKPYQISLSSYAVQLLSWGMGSAMAKHLPTRVFSTFGYKWSLNPGKWNAKEHALIVVAYWGSVSQTRKRSLIDKVALSQFILTLFDSATYGLGPLSALELYYGKRMNAGWGILFLITTQSIGYGLAGLFRDILVRPPQIYYPGVLPNVTLFNAMHRNPTVTAKSLKFFTYVACATFVYQWFPGFIFPMVSSLPLLCYMGHGNWIAYILGSGYNGFGLLDVTLDWNYTGFFSPLYTPLWANMHQIIGAVMTVWFLYPIMYFTDTLNAKTFPPMSSGTFDSNGSTYNISRIMNPDFTLNQAAMDAYSAPHWSLSYAMYFFWGFAASTGALMYAILWYGKSSYRSMVDAFKNIHNDYDDPYLKLMSRCERVPHWWYGLLLAICVALSIGQLYGGDMQLPWWGFIIILVVSTISTFPNGILWGIANFQVGMGFLSEVIAGALFPGKPVAVLACMTFGRQILEQNLNLISDYKFGFYMKIPEKGKSCCGISIVITFLYGTLLGPFINYGMMRVIIDNIGKDVLTGVVSSSAWDALKTKNYYSLSVLWGVIGPKVIFSSSSNYAWIYYAFAVGPIIVTISWLINRWKPHWNMEHYCNPVVIMYGATLFPVYQSANLMTSAAFSIFFMGYVYRYHPVWFRKYNYLLGVGLDCGTQIMQTFLVFCINLPNQSMPYWWGNNVNAYDRCFPPDTLPPNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QIH3</accession>
    <name>A0A3D8QIH3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cupin 2 conserved barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_11525</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QIH3"/>
    <dbReference type="OrthoDB" id="504210at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW61633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="209" mass="23524" checksum="74850659B8FD10C9" modified="2019-01-16" version="1">MQRSARTVTRDRLVFDFPEHGGLAFPTPASGSQVVTIRFHARSTARTGLHWHESHTEYVRVVRGVAQVTLGRDSFPVRASDGMLTIPRGVWHEYGRAVEAEGEGELVLEEWTEPEDGLKWRFFRNVLGVIADSGVMESPGAARGLWTLWQLLVVFSVHDNYPVLVKQGGFLSRWLTYSVLWLAHWSGWVVGLKGSYEEYVSEDASGSEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QJG3</accession>
    <name>A0A3D8QJG3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C6 zinc finger protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_11466</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QJG3"/>
    <dbReference type="OrthoDB" id="5386330at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052400">
        <property type="entry name" value="Zn2-C6_fungal_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47657:SF7">
        <property type="entry name" value="STEROL REGULATORY ELEMENT-BINDING PROTEIN ECM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW61574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="38399" checksum="60FD0E4B07E78A49" modified="2019-01-16" version="1">MSSGIQDLDMNHLHLLHHFCVSTFETMHHDPLIRTLWRTTVIHIGYAHAYVMHGILSISALHLAHLHPEQKLSYWAQATQHHHLGLSIATSKMLYVSQENCSALYIFSVLTFMFALASPRKGEDDFVLVGEAGLSEWLVLLRGSAHIANFASEGLLSGPVAPIFVNGRRRNDERISRSENQCAETDQLMELYDLISRRTMGVEAKEACCTAVTALRRAYAAFYTPTSASTPFKRPEPGDVFSWVFQVPKEFLVLLAARSQESLCIMAFFAVIVHPLENIYWWLEGLSGHLMTKAYALLDDEHREWIAWPLEVIGWDTIENLGKTPWQDTMVDNDAFGLGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QM56</accession>
    <name>A0A3D8QM56_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">sphinganine-1-phosphate aldolase</fullName>
            <ecNumber evidence="14">4.1.2.27</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Sphingosine-1-phosphate aldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BP5796_11083</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 16 17">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism; sphingolipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Sphingolipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the group II decarboxylase family. Sphingosine-1-phosphate lyase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.27" evidence="14"/>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QM56"/>
    <dbReference type="OrthoDB" id="10254570at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008117">
        <property type="term" value="F:sphinganine-1-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030149">
        <property type="term" value="P:sphingolipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.140.2150:FF:000002">
        <property type="entry name" value="Sphinganine-1-phosphate aldolase Bst1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000020">
        <property type="entry name" value="sphingosine-1-phosphate lyase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050477">
        <property type="entry name" value="GrpII_AminoAcid_Decarb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002129">
        <property type="entry name" value="PyrdxlP-dep_de-COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42735:SF6">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE LYASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00282">
        <property type="entry name" value="Pyridoxal_deC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 17 18" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 16 17" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0746">Sphingolipid metabolism</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="16">
        <location>
            <position position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004760"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00042568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR602129-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDW62781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="567" mass="61253" checksum="DBC2DFFC99289EB4" modified="2019-01-16" version="1">MPGSSRMPVSLRNSFTVKKGGSSSQLLALNIDLLRNIVFFLFLMRWTRKGLLKLKGRGLFGTILDTYIAIRRNLYGLFLRAPGVRSQVQKQVEEAITKLQAKLVPSGPDVTRYLNLPKDGWSEETVLKELETLATMDHTRWEDGYVSGAVYHGEPGLIKLQTEAFGKFTVANPIHPDVFPGVRKMEAEIVAMVLAMFNAPVGGAGVTTSGGTESILMACLSARQKAYAERGVTEPEMILPETAHTAFRKAGSYFGIKVHLVACPAPLYQVHVPSVSRLINSNTVLLVGSAPNFPHGIIDDITSLSKLAVKRKIPLHVDCCLGSFLVPFLEKAGFETELFDFRLKGVTSISCDTHKYGFAPKGNSTVLYRTAALRTYQYFISPDWSGGVYASPSIAGSRPGALIAGCWASLMKTGETGYISACHTIVGATKNIIAAINEHPGLNTDLQVLGHPLVSVVAFTSKTLDIYDIADAMSSKGWHLNSLQTPPAIHVAVTLPITKVWEKLVADLEAVVEGEKEKERVRIVEGKGAKGKAVGDSAALYGVAGSLPHKGVVVELASGFLDTLYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QMK5</accession>
    <name>A0A3D8QMK5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNA binding methylated-DNA--cysteine S-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_10996</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QMK5"/>
    <dbReference type="OrthoDB" id="2548197at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06445">
        <property type="entry name" value="ATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052520">
        <property type="entry name" value="ATL_DNA_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014048">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036217">
        <property type="entry name" value="MethylDNA_cys_MeTrfase_DNAb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42942">
        <property type="entry name" value="6-O-METHYLGUANINE DNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42942:SF1">
        <property type="entry name" value="ALKYLTRANSFERASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01035">
        <property type="entry name" value="DNA_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46767">
        <property type="entry name" value="Methylated DNA-protein cysteine methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methylated-DNA-[protein]-cysteine S-methyltransferase DNA binding" evidence="2">
        <location>
            <begin position="10"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW62694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="141" mass="15295" checksum="C3808DFA2A1ADEC2" modified="2019-01-16" version="1">MPRTDEAEAFFHAVYSAIQEIPPGKVTSYGHIAKLVGTPQRPRQVGVCLKHLPDSPTFTHHNGNVPWQRVINSKGIISPRGHQSGAANQAQVLRAEEVTVSTGSLGELMVDFSIYGWFPKQLPSEEAAGLTAFSDGEEEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQD5</accession>
    <name>A0A3D8QQD5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">Altered inheritance of mitochondria protein 24, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_10489</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the AIM24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW63987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQD5"/>
    <dbReference type="OrthoDB" id="5295771at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.160.10:FF:000001">
        <property type="entry name" value="Altered inheritance of mitochondria protein 24, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.160.10">
        <property type="entry name" value="Mitochondrial biogenesis AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002838">
        <property type="entry name" value="AIM24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036983">
        <property type="entry name" value="AIM24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016031">
        <property type="entry name" value="Trp_RNA-bd_attenuator-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36959">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36959:SF2">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 24, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01987">
        <property type="entry name" value="AIM24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51219">
        <property type="entry name" value="TRAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="339"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW63987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="383" mass="41607" checksum="614CBEF472ACA8D5" modified="2019-01-16" version="1">MPGRVRPDIAARGFRQLGRPSGLHGRRSIQIRATPTTESPVLTGDVLSNSIDASTDPADARFEVLGAPYSLLSVSISASQKLYTRRGTLVGVSGKAENAQSTLSILEPFRRAALGIPFLYQRISSTTPLTALISTKSPFTSFTVLHLNGTVDWMVAQRKALLAWTGHTLAVTPTMNRSMSLAHWGNSKMTGRGLVALAGPGQVYQITLKAGEEYVAHPGNVVAYTITQHPPLPYRLKSSSLRFQIPSLGLGRLVSDVKFFRVMQTTDTWKSVTRLLFNLRTSARRTIWGDRLFLKFHGPTTILLSSRASRISDVLTSRDVNEIADSPAGAVQSAVTLATKPEEETTAPRRQASVKPTGFHVAEVTRGGEVKFGDVKEVKSSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQP3</accession>
    <name>A0A3D8QQP3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 10">Conserved oligomeric Golgi complex subunit 6</fullName>
            <shortName evidence="10">COG complex subunit 6</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 10">Component of oligomeric Golgi complex 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_10472</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="function">
        <text evidence="10">Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the conserved oligomeric Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Golgi apparatus membrane</location>
            <topology evidence="1 10">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the COG6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW63970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQP3"/>
    <dbReference type="OrthoDB" id="272987at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010490">
        <property type="entry name" value="COG6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048369">
        <property type="entry name" value="COG6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048368">
        <property type="entry name" value="COG6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506">
        <property type="entry name" value="COMPONENT OF OLIGOMERIC GOLGI COMPLEX 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20653">
        <property type="entry name" value="COG6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06419">
        <property type="entry name" value="COG6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01087">
        <property type="entry name" value="COG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric complex COG6 N-terminal" evidence="11">
        <location>
            <begin position="131"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved Oligomeric Golgi complex subunit 6 C-terminal" evidence="12">
        <location>
            <begin position="275"/>
            <end position="769"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031348"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00043873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF06419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW63970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="770" mass="85054" checksum="76D5C972D0082DFB" modified="2019-01-16" version="1">MFRTGSHLETGAGAFGHREHAVSMKAVGIVPAEHTATSPIGSVTPRSSSYINLARSRADCLVQHLRFWSYLNMATDYFAGMKCPSVADELGSPSSPNNPLAIRSNPLSTKLSSVLSASYADSDIKDALGLLDKRGIQNSAETRRQLRLDIQKEVIDSNGEIIREFGHVADQLKRIGATIAALNQGCEEMKRHISAAHQETAPVLEEASELLTQKEHVETKEQLLNAFKAHFILSEDDVSILTSTAEPVNDHFFTVLTRAKKIQNDCEILLGTENQRLGLEIMEQTSKNVNSAFQKLYRWIQREFKALNLENPQISSSIRRALRVLAERPSLFQSCLDFFAEAREQVLSDSFYTALTGTSANGDEDSSLKPIELVAHDPLRYVGDMLAWIHSATVSEREALEALFISDGDELAKGIQAGRENEPWNHMASEQDSSSNFDGLKALNDLTDRDVAGVARVLRQRIGQVIQSHEETIMAYKIANLLNFYRLTFAKLLGNDSILLDSLTTLEESALRQFRALMRDNVASLQGEAQTAPIDLGPPDFLQEGLKQLTAIMKTYETSFTAAESREADFESTLVESFDPYMKAAQGMVEAIEPPESAIFDINCLLAAISSLAPYKFTNQRVAKLQSFVAEHSKVLTEHQYSYFRSKSGLEPLLTALAHLTNSPEDIATISASDACKPEVLTQASQTLDNFLPSALMDAMENLKLLQSSKLIREITEEAAEKFCDDFEQVEDKLLAADGLVEQNEGPVGSTQPLKALFPRTSGEIRVLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQT2</accession>
    <name>A0A3D8QQT2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_10530</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQT2"/>
    <dbReference type="OrthoDB" id="433512at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006817">
        <property type="term" value="P:phosphate ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17364">
        <property type="entry name" value="MFS_PhT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004738">
        <property type="entry name" value="Phos_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00887">
        <property type="entry name" value="2A0109"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24064">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 22 MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0592">Phosphate transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="200"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="422"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="523"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="59"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="555"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="621"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="649"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="665"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW64028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="728" mass="78534" checksum="A98DDBEC0F7D9E10" modified="2019-01-16" version="1">MDDLGEPAVPTSHVRTYGGNAAFHNFHNDYSHISDPNLRRRLALSEIDKVPFGWYHVRAVVVAGIGFFTDSYDIFAINLITEMLGMVFWQGEPSAGGNRGELPTSVGTALKAATSGGAVIGQLGFGWLADRVGRRKMYGVELAIIVFATLAQALAAPSQAVTITGLLIWWRVMMGIGIGGDYPLSAIITSEFAPTRWRGAMMAAVFSMQGAGQAVAALVALITTYAFRSALLTTTNESSSCNAVCQLATDRAWRIIVGFGGVPACFALYYRITIPETPRYTFDVAHDIEKADADIKAYIANQAEGHVDPVVQINTKQKIGSDLSKTNPHASWHDVWSYFSTPKNAKILIGTTTSWFFLDLAYYGLGLNNTTVLNAIGYSTGSTMYHKLLHTAIGNLVLVCAGSIPGYWISVLTIDTVGRKPIQILGFFVLTILFCIIGFAYDSLSSGALLALYILAQIFFNFGPNTTTFIVPGECYPTRYRSTGHGLSAASGKIGAIIAQVIASPLLSKGAKPGCQGNACSPWLPHLMQIFALFMLCGTLVSFLIPETKGRTLEEISGERTSSLDAGPQHPPPARSGWKKWLLDPITGGLPAGFHPASKAGPRSPRPFAGLSMNRRQRIGIMTSPELLPKSSTSKSESRLKFKSRKKNRDLESQSQHERSESESGAYTVSVSSSGNPNMEEIYTGGGPFPGWGAGWNVQRHGHANGGNLRSDGRVESILLYDVGKLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QR08</accession>
    <name>A0A3D8QR08_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ATPase-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_10758</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QR08"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF3">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="1">
        <location>
            <begin position="491"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW64256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="697" mass="78469" checksum="CAAE35D6FE30381A" modified="2019-01-16" version="1">MYLDNGQPAGELRPRLKMWKSLTPQLPFVTKARDHYSSNPSSTPSKELLEAAALVPGKDADFGTFAAVKTFYEGDNSRPNAYNWVDTPPKQLNKKVAKANDRVAIKIFKIKDESQATIAGRTPLKIHAIELQSLVLVMALKDILIAENHWLEVTEPAKFQEPFKPLFFCYDKIVALKEETDGETVLGQHLQLLCQVMGEMFGGLMLQLKNLRASGLVSYKLAWAYFPRDSTIFSANDAATRVCRVLSTEYVTSLHPHLAVYCKEICFDGEAFSWKPFMLPISEFGGNVPVNSLSNYPLSFHPDPESVVERVKSRGKRVVEYQGLVHCEYSGLGILDRGKCIEKHNVSSRILIDNVGYHKHYEGVARKEAPIPQIPLPGLVRDFRIETNEGPAEQNTYLQPISEEQQQKNKEELLAREQDLLFVSPMLKGFSLKNKLWLNFFVDDITPVVWNDEAYGHLVYPEEQKDLVLTFVETHQRLGTSVDDVIMGKGQGLIVLLSGPPGTGKTLTAEAVADKTRRPLYYLQAEDLGTNAAYLGPKIKKVFEMATEWNAVILLDEADVFMAERSPADIARNELVSIFLRELEYFRGIIFLTTNLYATIDAAFRSRVNIHLVFHPLSVSSRLVVWQKFLSRLPAATTALSDADLHQLARWDLNGREIKNTVKTVRTWCTCKGFEMTLARVESGIKVTAPEATKEEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QR68</accession>
    <name>A0A3D8QR68_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aquaporin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_10642</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QR68"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF199">
        <property type="entry name" value="MIP17260P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="201"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="257"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="261"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="312"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW64140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="321" mass="34085" checksum="BBA007D431605234" modified="2019-01-16" version="1">MGMCLVGALPYLRGVFLVISQILGGITAAAICSALFPGPLTVRTNLGGGTSVVQGLFIEMFLTAELVFTIFMLAAEKHKGTFIAPVGIGLSLFIAELTGVYFTGGSVNPARSFGPSVVSHQFHSYHWIYWVGPILGSLLASGFYLFIKMLEYETANPGQDRSGPEGEHFNPDLHRSESNPRVSFAPEDYAMEEGRVGKPAATLTAGTGHYGEPQEYGTAARPFSDSPAPPHPNDQFAGLAHGMHGDEAGLQAASVSNASDSTMVTPSAATTAPPTVNNQKSALKPARGGYTNGREHSVNSNTFNNRVIGASTRDEDFYDHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QU75</accession>
    <name>A0A3D8QU75_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QU75"/>
    <dbReference type="OrthoDB" id="10479613at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW65238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="167" mass="17625" checksum="C444CBC8008BA175" modified="2019-01-16" version="1">MPSTVDDHHRLMYAMLKATSGNFTEKISWADINKEYDPSSTLQAGSIKQRWARFKKAIEDSGTATGSGDSGEGDKDSGKAKDKDNDALVTPTPKKRARARTATQSDGLPPTPSKKGKKTPPAKKKKSEKVVDADADVDADVDEDKDEGEGDGEGKGDATAGAAEGDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUM0</accession>
    <name>A0A3D8QUM0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ARM repeat-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_10144</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUM0"/>
    <dbReference type="OrthoDB" id="49511at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052587">
        <property type="entry name" value="TELO2-interacting_protein_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057567">
        <property type="entry name" value="TPR_TTI1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057566">
        <property type="entry name" value="TPR_TTI1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016441">
        <property type="entry name" value="Tti1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049362">
        <property type="entry name" value="TTI1_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460">
        <property type="entry name" value="TEL2 INTERACTING PROTEIN 1 TTI1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18460:SF3">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24181">
        <property type="entry name" value="TPR_TTI1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24173">
        <property type="entry name" value="TPR_TTI1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21547">
        <property type="entry name" value="TTI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005250">
        <property type="entry name" value="UCP005250"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TTI1 N-terminal TPR" evidence="2">
        <location>
            <begin position="13"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="TTI1 C-terminal TPR" evidence="3">
        <location>
            <begin position="765"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="797"/>
            <end position="826"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW65452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="966" mass="105547" checksum="4C5AD790503D6B3F" modified="2019-01-16" version="1">MDTRTGASRNELFQELRPRCIELSELARRDDGTTKTAKELAESTSQLLNLLEQKCRRVDGAFDPKLADYVFFPLSLILRRKETISNRLTELTIKCLNILIVYGWKNAISLDLAKQLLLLLTFVAGGVPGQESKLAPEELIVEAFKALAALFKALSTTPKGPQSLVETSTVPALGHCITVILEGVTDGPSAAVQLQALRALDAIWACVKDLQALSTFLPGTISGLTKCLMPSTKSKRSRKTIVTALQVLQHVLTSILGDIQARVYKDKESSPGNEQQTLTKPWLKATTDQIKLALANVIRLRKHESVEVHQALNKLCLVLLDECHDTLRESAAMLVETAMSLFEEEVSGDLLRRQTSLMDLAVIHTDIAELIKTTVYNWTTSLPRVMQSNDETAKVEALRSLSRAQKLLHDLNLESSILKETLAASLRDSVTATLDPGTTRKKLEEAPFDLNSQALTSLATENAQVIDFKPILMSGESQKQTRQQLQTLLANLGSRSSQIDMANEMLEYMRGAEGPSLLSAYWLSYHLLQAASSANADLDEFLEASVTFSEEEEAANQELFSYSVSLVSESTTTRSDEQDWRLQGIALEVIASTALRMKESFRTELIDTLYPITTLLGSPSPNLRTHAITTLNVLASSCGYQNTSALIVDNVDYMVNAISLRLNTFDISPQAPQVLVMMIRLTGPSLLVYLDDVVASIFAALENFHGYPRLVELLFSVLGEIVDVGSKGEQLKLPSATSTNALQREIPTGPTIGSIVDILKKRKQTQDSNASLDLAHEDFPRSPWKSAKELLDEADLARNPPSDSAEEEQAPTSHSTELAPAPPSKTHTMLTSITRLSQHYLTTASPYLRTKLLVLISKSSLALSNDQDSFLPLLNDIWPVLIPRLHDPETFVIIAAARTLSTLCNSAARARVEREGREGAGQARRLCAEFAGVGAAAKVAGRYCGVHGGECSVVGGGTGIAWPGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QV69</accession>
    <name>A0A3D8QV69_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_10273</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QV69"/>
    <dbReference type="OrthoDB" id="5241722at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="456"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="517"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="66"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="460"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="517"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW65581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="575" mass="60495" checksum="A6D14C5930BF40BB" modified="2019-01-16" version="1">MEFQMPEANSFQSSPTRVIATVTEIYVAGDPLITPPPELRLRNALPEPRPQADCGQISQQASQSAAQAIQQASQQAQQSIQQAQQSIQQAQQSASQQIQQATQAAARSVTDAQNSASQAIAAASRTASQASASASFASVSAQSAVASALSRMSAAESSQSQAQSQASSVMLQAGAAVAAATGSAAAAGSSFLAAAALATAGAQASVSGFAALASSQIQASQVQAITATQVALAIVGSIIASALITILIYFLISRRNNVKKDRKKASRERAESDVRKQRELDSPPPENFPKDLKFTPSDQDSSTVVGSVRGESMEQRNEASMQFRPTVGNDLNIKETSVRWNPNKPPKAPKLSSWLQEQTEQFPVKPIQLPINKQGQIPLGGQLKSPSRTIDPPTTVFRLAQEKSKPLAETAKRVQVVSAQKAVQVVQRNPSKKSVDSAQGEVSGPPGIAALARVTTTVTARERDSRVSQWTDDTRRSFSPPPAPMLGPGAVSQDSASVMQIPAPVAPVRNTAEWLASQSMSVPMSSQSRDSDSSLTVGWRPPNRGSSGNAAKVGLPSQVRMQNPTPEWGTVGKAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QVK3</accession>
    <name>A0A3D8QVK3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">T-snare protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_10236</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QVK3"/>
    <dbReference type="OrthoDB" id="10251371at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15845">
        <property type="entry name" value="SNARE_syntaxin16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.70:FF:000021">
        <property type="entry name" value="SNARE complex subunit (Tlg2)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF83">
        <property type="entry name" value="SYNTAXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="309"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="235"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW65544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="348" mass="38948" checksum="CFC04533C6F7B800" modified="2019-01-16" version="1">MWRDRTNLYISYRHSYAHHPSKKPAYSSTIGNGYSDGIDSERRGLMSAGAFEDDGDAIIEMDLLPPRWADISDEVTEYLTEIAKKSQKLEKLHQKHVLPGFDDEEAKSAEEAEIERLTQEITKRFHDCQKAIQRVEMMVRDSKSSGGISKGEETMARNIQISLAGRVQEASAGFRKKQSAYLKKLRGLAGPQPPIDRSSTPLYNNYNDPSMSAADADASYSSTVLQAQTTLTSNDSAIMQREREINDIAQGIIELADIFKELQGMIIDQGTMLDRIDYNVERMAVDVKGADKELKVADGYQKKTTKRKIILLLILLVAGMFILLLVKPKRHDSSPVPPTQEGENTLPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QVL4</accession>
    <name>A0A3D8QVL4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_10246</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QVL4"/>
    <dbReference type="OrthoDB" id="5424793at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="167"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW65554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="643" mass="72717" checksum="BF62C4BA3C10849C" modified="2019-01-16" version="1">MVVKRNQEMREHVKHVGQARVVVYSKKNNQSAKIRAKARPRRVRAGARCPNADITDKQRSAAQVTEFTFNLPSVTGPDSKNDVASLRSHHDVVFSTDATLEANYDTQSYFKKSPDSTAEMQQSIPSAPQIIQQRRISFKEASRLLLVFRTRMHFSPFVVIPPDATISSLSRTSPFLLLAILTTCATSDPDLHHQLDHEFRRVLSLKVIVNGEKSLDYLQGLLVYVSWYPFHIRPKNNQAFMFLNLATSLVVDLGLDREYPNPNISISDIRLDGLIDGYVFTKAAKRAYLGCYYLYSSLSLGFHKTNNFKYTDLMTTHAEALMRDEVPSDTSLYAMLRLQRLTERVGETSSATKPPVFDPITVSLSFEMNVQIFQNELQEWKATTPPPTQLLPFVGLAERFLNICIYSHELGSLRKPYHHANQILETSNDSDSPTHLAKCLMAGKRYFEFLLSIPETNYWDLTTVLWGNIVQTILILSRLTFLLAALNDWDADTTRENIPLGMYLECLCYRMQSLSRMAKLMVSQAAPAGDSKGTSTTATTATTPDVMFVFYLVMQSVKTSYERRVSNIKPNFFFVENGVAVGGARGHCPMMDPNLNPYFEPREETAWHSNGGEAEWDAEGKQVEIPALGNLWSTMTSSWAEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QXT7</accession>
    <name>A0A3D8QXT7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Lipocalin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_09392</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QXT7"/>
    <dbReference type="OrthoDB" id="3904217at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024311">
        <property type="entry name" value="Lipocalin-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13924">
        <property type="entry name" value="Lipocalin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017798708" description="Lipocalin-like domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Lipocalin-like" evidence="2">
        <location>
            <begin position="126"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW66643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="284" mass="30873" checksum="F34F228869B92747" modified="2019-01-16" version="1">MKLQQILSLAILSTISIAMPTQEDAKIGRTIIDNTSCKTANDACVTIKPVIPYPTPSCYQKDITLIMIDRYRSHISDQGSWLQGGVSPYPTLWSVNDISLIKTGKYSSAYLYNEPVSVIGEAYVLGAWKLISFEIFSDEASGSKLLGTSLGPTPLGRSIFSPDGYLSFILADPEPAKVFKSTALWLMAKDEDVAPPARAMMSYSSSFKIISDESGQVTVVTTVHISLDPAWTGTEQVRRASVREEDGKTILVLRPAQLGTLANGVAGVPVLTWEKMPSNDVFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QY33</accession>
    <name>A0A3D8QY33_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QY33"/>
    <dbReference type="OrthoDB" id="3513892at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="7"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW66675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="227" mass="26236" checksum="6DF5DB4D83F33398" modified="2019-01-16" version="1">MTSLESFTSFLHLPLELRTKIWRYSLPEPRVVPVQYNRRFEQYTSNTPQPALLHTSREARRVFLEKYDRLVLSPKYPSTVYVNFETDTIYFHDLDCSPDGDLALDLASSPHADRILNIAIDSELWEILRAFKLESLSELGLLRNLKTIALVEPRSLDVKGPPMDWMPEQGWEDVDGVVRLSRTTPARTGGLELGHLGFLFMLLRNELEARKEFEWGNGKPDVSMWLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYC8</accession>
    <name>A0A3D8QYC8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_09514</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYC8"/>
    <dbReference type="OrthoDB" id="245563at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF15">
        <property type="entry name" value="BLR5631 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="21"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW66765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="191" mass="20237" checksum="7D40A03A055B4A99" modified="2019-01-16" version="1">MAKAFRELIGVSPSTASTADSVLIIIDAQNEYAEGQLQTHNVSSTRATIASLLDKYREASAPIVHVHHRVPAGAPVFTPDTPLCEPFAELVPRAGEKVIPKEFPGSFTGTGLEEFLTASGRKKVVLTGYMAHVCVSTTARQADEKGFDVCVVEDAVGDRDIPGVSAQTLVEVTLKELGDAFGTVVKAGDIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYF8</accession>
    <name>A0A3D8QYF8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pyruvate dehydrogenase E1 component subunit beta</fullName>
            <ecNumber evidence="10">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_09544</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="10"/>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYF8"/>
    <dbReference type="OrthoDB" id="10266385at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07036">
        <property type="entry name" value="TPP_PYR_E1-PDHc-beta_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000001">
        <property type="entry name" value="Pyruvate dehydrogenase E1 beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000006">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027110">
        <property type="entry name" value="PDHB_mito-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005475">
        <property type="entry name" value="Transketolase-like_Pyr-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033248">
        <property type="entry name" value="Transketolase_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006667">
        <property type="entry name" value="PRK09212.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008854">
        <property type="entry name" value="PRK11892.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624">
        <property type="entry name" value="DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11624:SF96">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02779">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02780">
        <property type="entry name" value="Transketolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00861">
        <property type="entry name" value="Transket_pyr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-0630">Potassium</keyword>
    <keyword evidence="9 10 12" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0786">Thiamine pyrophosphate</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Transketolase-like pyrimidine-binding" evidence="11">
        <location>
            <begin position="52"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW66795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="378" mass="40863" checksum="57B8F8B827662311" modified="2019-01-16" version="1">MSRLLRPASRLLSSCAARPVAARSSFQSNTLPRIASIAARRSYASEGGPKEYTVREALNEALAEELESNPKVFVLGEEVAQYNGAYKVTKGLLDRFGEDRIIDTPITESGFCGLAVGAALAGLTPVCEFMTFNFAMQAIDQIVNSAAKTHYMSGGIQPCNITFRGPNGFAAGVAAQHSQDYSAWYGSIPGLKVVTPWSAEDAKGLLKAAIRDPNPVCVLENELLYGQSFPMSEAAQKDDFVIPFGKAKIERSGKDLTIVTLSRCVGQSLIAAENISKKYGVECEVINLRSIKPLDVETIAKSVKKTHRLLAVESGFPAFGVGSEILALGMEYMFDYLDAPAQRITGAEVPTPYAQGLENLSFPNEPMIEAYIAKMLRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYP6</accession>
    <name>A0A3D8QYP6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_09671</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYP6"/>
    <dbReference type="OrthoDB" id="41238at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008999">
        <property type="term" value="F:protein-N-terminal-alanine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000047">
        <property type="entry name" value="Acetyltransferase, GNAT family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051908">
        <property type="entry name" value="Ribosomal_N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441:SF2">
        <property type="entry name" value="FAMILY ACETYLTRANSFERASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G00850)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43441">
        <property type="entry name" value="RIBOSOMAL-PROTEIN-SERINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="2">
        <location>
            <begin position="54"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW66922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="255" mass="28746" checksum="24EFACF80C6D1F79" modified="2019-01-16" version="1">MLETHHDPPGKTVPDQPALPPTPITLNGQYCTLTPLSMEHAPVLYEILGGVENAAIWTYIPYGPYADLESFTEYIKTLEKGSPFFTFVIWVPKGSRLPAVPTGSIDAAHARPVGLISYLNIVPEHRSIEIGSVLYSKALQRTTAATEAVYLLIKHCFESLHYLRCEWKANSLNEPSKKAAIRFGFIFEGIFRKHWIVKGRRRDSWWSSMTDEEWDGGIQSALDAWLAAENFDHEGKQKKKLEEFRQGGTVVTKAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYZ7</accession>
    <name>A0A3D8QYZ7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09746</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYZ7"/>
    <dbReference type="OrthoDB" id="2507450at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017607145" evidence="1">
        <location>
            <begin position="23"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW66997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="165" mass="17071" checksum="3ABA86CF8A28CD0C" modified="2019-01-16" version="1">MLPPTSTILSSLLLCLVASASASSSFDPNSQPIDPALHRELAHEFAAGSPLRARTVTNLQTFTQALGGASAAPITNSGSPTKPFAVGADTFSDFASAATRTCNNQHNVCANMVNNGTMANAALTVADCDTQQTKCQAAQATATLQNFQVLVSSDANFDFICDSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R2R4</accession>
    <name>A0A3D8R2R4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_08974</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat MET30/SCONB/SCON-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R2R4"/>
    <dbReference type="OrthoDB" id="19711at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050995">
        <property type="entry name" value="WD-F-box_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604:SF4">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14604">
        <property type="entry name" value="WD40 REPEAT PF20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="F-box" evidence="6">
        <location>
            <begin position="76"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="299"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="326"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="450"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="490"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="189"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="581"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="768"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="194"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="768"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW68317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="858" mass="94772" checksum="0920EA114C28A4B0" modified="2019-01-16" version="1">MSALPMDSYEPSPLDEGYSEAPLAVGSNGPRSLAMPLWLAQMPAQDRTQYIMSIMDSLPTAEVCEIVRRLRPRLYINFFQHLPPEVCLKVLGFLDPVSLIHTARASREWMLLALDRKLWEHLYYLEGFRVIPAEVQNFEYELNSTLLNAAREASLKESHAARSLQSPLDVDSVMTGTLPPPLQYTSIFGGPSELPKEHNSSSGKGKEVMRGSTEDQVMADAPDRQRSTVTEDPFTTTSSLVIVDRSSKRKVLNWQYLYSQRRRLEANWEAAKFTNFQLPHPDHLNERHRECIYTIQHAGKYLVSGSRDKTLRVWNLDTQRLIHPPLVAHTGSVLCLQFDADPEEDLIVSGSSDATICLWKFSTGQLIHRMKKAHYESVLNVRFDKRVLVTCSKDKTIKIFNRHPLRPGDQGYPMTDIINPVPTFLNNYGFNPAPTAGLPVKPPYQIIAELIGHGAAVNAVQIHGDQVVSASGDRGIKIWNWPEQTCLRTFVGHNKGIACVQYDGRRIVSGSSDNEVKVFDKESGLEVASLRGHSDLVRTVQAGFGDLPYSVEEDREQAKAIDYEYFRAVDAGEVSRTVPLKRGRGRNAGSRKPQDITAYGAKLPPGGGGGNYGRIVSGSYDGNIIIWRRDKEGVWKAQHTLRQEEGAVAARSIRGQAPRTNGTQATTPPAEFQAQIAQIQTQAQPQAAIPTAPAITAPFAPGSQAHYNVLIDSALSQGSAALVVLLQTHPHLAQSAHLLASIANLAPSQRVQMNFVVTQIASAMPNNQPTGHVAAQATQSVQANPPAPQAGAPAPAPAAPHHHHHTHRTQPEVYRVFKLQFDARRMISCSQTPIIVGWDFANGDKQIIEASRFFAPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R2Z0</accession>
    <name>A0A3D8R2Z0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R2Z0"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="22"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW68413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="192" mass="20419" checksum="0C5103B2F57E5DA4" modified="2019-01-16" version="1">MMRRQLRWGASVIKICPRGVTVISDEAKRAGRGVAAHAHAKAGVMAALEMDSCLTIEHGTYIDEEAADPMKRKGVLLVAARFIIETRMQNLDHLPPAIRAKMVQFSEADKQTYALCVQNGVKIALGTDICSCDPSRIASAGKSGMEIGYAVAAGLSPLKAIEAATANGPETLGPQAPLSGQIYKSRLDTRAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R311</accession>
    <name>A0A3D8R311_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-nitropropane dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_09092</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R311"/>
    <dbReference type="OrthoDB" id="10265891at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018580">
        <property type="term" value="F:nitronate monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04730">
        <property type="entry name" value="NPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004136">
        <property type="entry name" value="NMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32332:SF36">
        <property type="entry name" value="2-NITROPROPANE DIOXYGENASE FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07940)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03060">
        <property type="entry name" value="NMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW68435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="351" mass="37105" checksum="9B8677A06029A091" modified="2019-01-16" version="1">MAPTGPITTPLTTLLGIKHPILLAGMARTSGGPLAAAVSNAGGLGCIGGLGYTPDQLREIIHELKSHLASPDLSFGVDLALPKVGDGARKTNHDYTHGQLDQLIDVTIEEGAKLFISAVGIPPKHVIDRLHGAGILVMNMVGAPKHAKKALDAGVDIVCAQGGEGGGHTGDIPNSILIPSVVDVARQYRPKMLKGQNALVVAAGGIYNGRSLAASLMQGATGVWVGTRFVACTEAGCSQAHKEAVVTASFDDTIRTLVISGRPLRVRRNEYIDQWEAQPEKIKELTEKGVTPLEHDMNEGVDFDIPHLMGQVAGVIWDIQPAGTIVDEMVLEAAKMLRQGQVYLGFYKSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R374</accession>
    <name>A0A3D8R374_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cyclase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_09156</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with coenzyme Q.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COQ10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R374"/>
    <dbReference type="OrthoDB" id="292693at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07813">
        <property type="entry name" value="COQ10p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044996">
        <property type="entry name" value="COQ10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901:SF10">
        <property type="entry name" value="COENZYME Q-BINDING PROTEIN COQ10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901">
        <property type="entry name" value="SPERM PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="4">
        <location>
            <begin position="38"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW68499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="243" mass="26948" checksum="B3E3E21F98A77896" modified="2019-01-16" version="1">MFRTLRPRSALRTIKTCERSFITFPGTEPQHLTATRILPYPSSKLYNIVADIDSYSEFLPYCIGSKVTKWSNPDQNGKRWPAEADLSVGWGGYEETFTSKNFCVPDSIVEALGGSATTTLPKSDLPNYTAIDTPGPSNTTFSSLSTRWTLRPFHYKPPPAQGDPRTDNTNEDAREQTEVHLVLDFEFKNPIYAALSKAVAPKVAGMMIEAFEKRARRLLDGPGARVSGRDPLGEHFAGNKMGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R390</accession>
    <name>A0A3D8R390_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_09103</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R390"/>
    <dbReference type="OrthoDB" id="3542212at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42052">
        <property type="entry name" value="ABM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42052:SF1">
        <property type="entry name" value="ABM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW68446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="214" mass="24402" checksum="0546CD758428E613" modified="2019-01-16" version="1">MTVTEFAILPLRTTQTTPLPSSLLAKFKTAKEVLEKASGFTFYFLQQIEDPSTVYILGSWPSVAAHHVFLPSPENQVLLELLEDTVTASEIQLWHLEADILKTSEGKQPTLDAPIISCNRHFVSLEKRAGFSEKMAAVKPLLEGYTRPYDVQGGWRIEKEVVQGTERDEWILFSGFEDVDHHMAFAKTDEFTKYREIVEFVEGFEVKHLKKLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R3E9</accession>
    <name>A0A3D8R3E9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09229</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3557174at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="402"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1047"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1152"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1284"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1542"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1729"/>
            <end position="1751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="701"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="718"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="743"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="793"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="841"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="946"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="966"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="990"/>
            <end position="999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1047"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1059"/>
            <end position="1072"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1152"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1222"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1290"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1548"/>
            <end position="1568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW68572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1883" mass="209123" checksum="B206D74D82068462" modified="2019-01-16" version="1">MAPKASQKELEKHLAKLCKELAQESKGHGTIAISKATCKALLDSIDLHSKHEESIPPTSVAKVLGVIDVGGNDICCRIDETIFQALVAFFLNVLPAYGSQRGVYLLADALHQGHTEPNEHNFANKKKKIGHGCSFVLLKYFIDPTRFTGMRRWMGVLLLQLLKGCPNNIVYLLKVSGDYSRQLGDLIVNDNNEIIRIVSADIVEAVLKVGMSAVDLWPLDTKPNIYQHFPAKKDAGYWIKDLASYMDYLEEHKSLRDIRNGDHTSGRLYYPQGILVNPDLNIDFGKSLYMLLDNKELTIFSRGSENGFYCSLEMPLTLLVHPKIDERSFVESQRAEALWDMILHPEDTDRCYLNASDTCLKSMCIALPESIREAMKDEIELMAVQASRGHVPRASIVEYAIDDSDESHDSSEVDGENKESPFAKDSPDAMPSDTQRATSAEQVRNSPSEIPSKGDRVMETLSDDERTSSSGFLALLELQHVDESKVLPTTKTPAGCGDEDEDSSRVRSDNLHNISPPKKTRNPTSDYRAIQNQPQVDHDNKLPTVDTPAESSPNSTKSQQKNDDRDRVHKLTPQETLNRPFRAPSKVANGVNSLKEFPLRQVVRSPNKSSIEGQNHALEESPQPPLILDDETSPSEHDASTPKPQTEQVGTKPMKVLEPDDTRQKFTPHPLPGFRDSGLQAKKDNIVANTQHVSQSNDSVDADRVNDAKAPLEGKSMAQRQEISTVSRTQETQKKGTSLKAKQPLDLKKDFPPSKPITYTQVEAQRESLSLKPASHPKSQGPKLLKTNKKSHSTREVDKTYHDQKDVFEIPKDNEQEESKLQSRKAKKSLKEKPNKSLKLPSKKQPKRVAGKSREPALSVLDLQEPRANPRRSNRVANKQARRVNYTEIDEELQNPHQPEEGVGSLGEPVTRKNINTDPERQILFQQTKATRADMTGHAMLSKRKSSVDDEKTSIAVGERSDRGQQHNTSVDNTAMDSGPLDDRARSVGDSKTATSKHSNGVAMAKSLESILADLDTSHEGVDVGLAMDGKLAQDLNANFDLEQDRDSAYQHSRDHRPVSISSSSSKSVSPDPEVESALADEVANQPVEHLIKKAASKNAEESAPLHAGSSVESIIDSVSPFKGAALADSSQRAESYETDSCDQINDVEQAIATNENGKRTSPNAPITPAKRRKGPPKLINLTSSQERSPRTSRHIQLQDAAVIKQTERRKRYTQPSTPPRRSPRLSAKAKRATADLETVLLPLTSLVDEKKSRKPTIVNFGSTGPKNQGRPSIVSNAVKQSHVVQGRTAELHETKEYVRRPTPQAVKPSCDNEAGFVDGAGSFKEDYMNISAVGEVTGDSVEPKTAAQDVISVKTREIDDLRIQYAGGTKLSGPGNGDSISAPVGACWNDVKKNGYKKIENPSRRPCNDLKTAFTQGTLKENKEIQCTSSLPHDQMELRAGAAQRELNDNLEVDHARATKQPEMLLIDNVDLGYAASAESSAIMSSTQRKRKRTAANTIAGQPFIKSPQIKRGIERDRHKTNASDEENRLLDITTMEYPPQRRRNLRYSSQSSRVNLNGSPLASQKAQPVDHIGKVSKGLFRHSMQEQDVLGLASPEPQPGRHSARNDRRADAIALHRPARISSSISKARPSSPEHEEPRYVPHKRNLRTGAYEGMDGSEVIADDQVLPDPFTGKARRVPNGFSKRLQESQIDGREDMFAKVKRIFGEDSEPNDGKRIENEETLVNSVDVNENTPSSRHLSNSSPMLRGDLSSQVETEKGSVGHWLLATKPHYKDLFQVQDFIIEEMRIRLAKQENAIHAVWQQYRDKGNTLLQQWETKRGDEMQDIMENLENHRSHLLTVCGEARDSLNSISNSLRSSPTDLLEKDWHRKQAEIQASLAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R3F0</accession>
    <name>A0A3D8R3F0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_09137</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R3F0"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11070">
        <property type="entry name" value="CYP56-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050196">
        <property type="entry name" value="Cytochrome_P450_Monoox"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291:SF50">
        <property type="entry name" value="BIFUNCTIONAL ALBAFLAVENONE MONOOXYGENASE_TERPENE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24291">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="509"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW68480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="579" mass="65899" checksum="4C23007EDCCE2FA7" modified="2019-01-16" version="1">MLYCYVPIVFFSLVAWQGLKFYKNYKAAQEIGFPMLASPIDKLNRFWLLTKDFLTPLLRRLPFGLGEFSQRAYMGWNFPDFYKTHARLKSDAFTIVTPGELEVYIADPESAEDILKRAQTDFVKSPALYDILNFLGQNVNTTNGMTWQRHRRITTPPFNERNSAVVWQESLKQTREVLEFWEELGNVRTTTDDSMTLALHVLTAASLGVKYSFRESLTSKPQTTSGYTLTYRDALNTIIRNMGLAILFRMVEKLQIPKAMLPAKMKKMKLALDEFHRYLTQMVKDERVAIATTGNTGLTTDKANLMSVLLRSSDQAKAKANLEATLGEESPTNIAYLSDEEVYGNLFVYNVAGHDTTANTISYAVILLAIYPEWQEWISEEVDKVFSEGVGKDTGQWDYEKSFPKLRKCQAIMFETLRLYSPVVSVPRYTAHSRQTLSVNGKSYDIPPHTNIFVNVAALHTNPGYWGDDALTWRPSRWITKSTSLDEDTVIKAQPPGVFIPWISGPRVCPGKKFAQVEFVAVIAAMMSSWRVGIVREGAETQEQSRIRALQIVQNSKVEFTLKMKKPNGVGLKWIRKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R3M3</accession>
    <name>A0A3D8R3M3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_09284</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R3M3"/>
    <dbReference type="OrthoDB" id="4682787at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF96">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="211"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="34"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="301"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="320"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="358"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW68627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="370" mass="40739" checksum="C10A179E30E3418E" modified="2019-01-16" version="1">MATAAAAAAAGIPYSTNLGLPLFELILVWTTVSLRIWVRKFLVKNFGLDDWFILSALILYTALVGILLRMVHYGLGQHIEGVSQEQSVAILHLFFFYELGYSIVTTIVKISISLLLLRFSFRRTHVIIIWALAIVMTVVGVFFCFITIFQCSPVQSYWDHTIKGTCLSKTVYIRATYVGTAFNAVTDFVYALLPLCMLWSINMELRTKVSLGLVLGLGSLAGITNLVRIKLVHTLSASDDFTYQYYYITTISTIELAVGIACASLATSRPAFRTIANKVMARFSSSAESAHSREAEYAQKSIFSSGAGGGNEGTRPAMGSSKQAEQMQSSTHLLEKDEESQAGLKATMSGGRKNRRSQFCEHLDSDSEGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7G4</accession>
    <name>A0A3D8R7G4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_08376</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW69979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7G4"/>
    <dbReference type="OrthoDB" id="406156at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF172">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopenicillin N synthase-like Fe(2+) 2OG dioxygenase" evidence="5">
        <location>
            <begin position="238"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW69979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="308" mass="34825" checksum="CCCE7C8AD76728B8" modified="2019-01-16" version="1">MTTALFNPPSPSISKPTVPKWIPPKTTEMVTDWADLRTIDLSLLDSPDPAVVEELVATTKAAIKEDGFLFLTDYGLHRQFDLAQYLHSNISQGDRERLHWDPSKGTFAGFKPRLGWKKEAGAPDGIEQFNFYSPQFADHEKVPTCILPFMDEITSFCDYLMNSVNRRLLKLLSKVLELPDDYLWGLSLPLHLCRQPVQILIRLADNVQSHTGLVGEGYYRHALFYPLEGEAKTAMKGIRMYGHTDYGTTTLLFSVPITALQIWTKDNKWKYVPYRPGALVINLGETLEGSSRSLVVSDFEAQADRLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7H3</accession>
    <name>A0A3D8R7H3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7H3"/>
    <dbReference type="OrthoDB" id="58379at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38696">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38696:SF1">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW70002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="284" mass="31960" checksum="3B0E34CD1D02EB88" modified="2019-01-16" version="1">MNKLNPNPTYSEKAPMPAPPPYSSSATTSSSDSPAASPTTFVALSLHATDKLRLLQFPKAEVPAFRTVIQTYWHRGIQREQPYGGSLEFKLHGHPWVGQGSDAIPSRVLMANLIQHLYNSGWRLVVATDCSKKSSDTDSLLFRRNDARSTLPGAGFVEPREEVDVLAVSFNQSDRLRLVGADESLIQSFRTMLKSMQKLQAESWKDRKWNAYEFKLHGYSWSTGGVETMTTRLLLLRCLETLESHGWCLYASLDQNTGSEGSDLDAWYCIRRKNWVPGMEVLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCI8</accession>
    <name>A0A3D8RCI8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative aldo-keto reductase-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_07700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RCI8"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19077">
        <property type="entry name" value="AKR_AKR8A1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF78">
        <property type="entry name" value="PYRIDOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW71666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="331" mass="36660" checksum="D378CCC477D3A47D" modified="2019-01-16" version="1">MTFKINNKVVGPVAFGLMGFTIRPQQTPYSQALKTMKAALDNGANFWNGGDFYGPPNANSLQLLNHYFTQYPEDKERVVLSIKGAFSFHPIGPDNSPENIRKGIDTCLEVLNGKVFVDIWQPSRADPKVEIETTIRAISEYVKAGKIGGIGLSEVNASNIRRAHAVHPITAVEVELSLFTTDALTNGVASTCAELGITLLGYAPLSTGFLTGEFKKFEDIPENDLRRTLPRFQPDLFHENLRIVEEVKKIAERKNCTMAQIAIAWVKSLNSKPGMPRIIPLPGTTSVARVEENTKEVLLDAEEVAQIDEILARFPVQGHRWPAFLQPFEDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RD74</accession>
    <name>A0A3D8RD74_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">BHLH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_08016</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RD74"/>
    <dbReference type="OrthoDB" id="690068at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11387">
        <property type="entry name" value="bHLHzip_USF_MITF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.10">
        <property type="entry name" value="Helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011598">
        <property type="entry name" value="bHLH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036638">
        <property type="entry name" value="HLH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051732">
        <property type="entry name" value="USF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117">
        <property type="entry name" value="FI24210P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46117:SF3">
        <property type="entry name" value="FI24210P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00010">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00353">
        <property type="entry name" value="HLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47459">
        <property type="entry name" value="HLH, helix-loop-helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50888">
        <property type="entry name" value="BHLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BHLH" evidence="6">
        <location>
            <begin position="341"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="178"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="320"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="386"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="503"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="182"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="224"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="274"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="526"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="574"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW71982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="584" mass="62924" checksum="C4A07C1E6E1FE23D" modified="2019-01-16" version="1">MAGTGASSPFIKDEPEDQFFSSNNRFIGGGQQGFNMPQQHFNQFGSHGGSINPHDLAMGSNGMAIQNGYGTSYQNNNFTTQAPSNPSYSKGISSTFNDDELLDSLGTMDSHSGQASMNNGQDFGMDFDFGQNMYAAQNGTAALSVDSHHINGYSSTPDGDPIQSPFVHNFNQAQFRQMQQQHFGSSLQSPASYNNSPVPGADAPSGSLDANYMSAKQARPRLNQMAQRKSSSTRSPLTPKTPAIPSLNIGSADQPSGFPSQPIRTTQSHRHQKTLSGQWDQHASSSLNSFPGSEFGSPVQGIHPNPQISDILKGASMPSKMNGATAASAPALQSQEMKRRRRRESHNLVERRRRDNINERIQELSHLVPLHRLEDEKVRKALQNNSPLSPTLAATGMSPPQATSGLAGPGARRATAGNITTGIPIEEKDKGPNKGDILNGAVSWTRDLMWMLHTKLQQQEDLANLISDLGGKFPFEQTEDERRMHTELMDAMTKNNPLSFHYSRAPGTGLRVPKHTDVKGDPVGGLSQTQLDDSVSPDNHSSGDAGQAGMGGAGQYWSGHNSGGSGPGSISFKEEDEYGMDLTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RD89</accession>
    <name>A0A3D8RD89_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative proteasome regulatory particle subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_08051</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RD89"/>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050745">
        <property type="entry name" value="Multifunctional_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189:SF50">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24189">
        <property type="entry name" value="MYOTROPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="168"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="201"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW72017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="262" mass="28810" checksum="A393DA4EFA087444" modified="2019-01-16" version="1">MTDKNATSKFQIHEAARDGKRNDYLKYTNETANPKLADQKDDDERLPIHWAVSYGHLDIAILLASQKNFDPDVQDGSGWTPLMIAVSLKEGEELVDLLLRKEADVNSKNFNGQVHFLRHNLYALPLVSTNTIPAKTALHFTASKNNLDVARKLLDNKPPASTRVKDKRGQYAIHRAAAVGSVPMVELLLKNRSPLNPSDIAGQTPLHHAIAEGHGDTAVALLKAGAETDKKDVDGCLAMELAPDAQVRKFILQTAEREGIDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDM9</accession>
    <name>A0A3D8RDM9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7908 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_08179</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3563678at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057230">
        <property type="entry name" value="DUF7908"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25485">
        <property type="entry name" value="DUF7908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017657652" description="DUF7908 domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="1454"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7908" evidence="3">
        <location>
            <begin position="106"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW72145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1454" mass="143851" checksum="E34FD2CED5EA368A" modified="2019-01-16" version="1">MLYKFLLTILGIIVLGNATLLPNELECLERQIQYVQVFIVEYPVLINTYITVNTIINVNGGLIININNAPTQLITTINATSITTVTSTITTSTTATATAIATTTTTESSFVLSIIPVATGIAGTLRKRQESLDLYVGTGGLAVNTSQIAALCTIRNDQLFHGTQHFSTNAGVVQAPFEYSSVDGTISTIFSLDGSALVWSNSNFAGGAAEFCSLDGIIQVIFNGIIPAGCSKVSLIAVINTSTSITTSISTSATSVTTTSGVSTSTSGTLATTNTGTSITPGTSAGTVTTTSTSSTSSSTNTGISISGNSTTTLGGSTTSTSSVSPTTDTNTSASSTSSTTDTGISTSSTLITTDTTTSSTSSTTDTGISTSSTLITTDTTTSSTSSTTSTISTSSTTSTISTSSTSSTTDTAISSTPSTSTTTNTGTSISSTSSTTDTAISTSSTSTTEASGTSTSDTSTTTNTEASISSTSSTTDTGTSTSSTISTTDTTTSSSSTTSTTTSSDTFSSSTSTTATPTPSPTATCDGSTAILDSVNNVCVCTTPSDILNADGSSCSAPPPACNTATGATLDSSSNTCTCTAPLLLATDGVSCFTPPACNTATGATFDPTTSTCICSSPQVIGTDGLTCVTSPACDTVSGATLDLATVTCTCSSPLVIGTDGITCVTPPACDTLSGATFDPSTVTCTCSSPLVIGTDGVTCVTPPACDTLSGATFDPTTVTCTCSSPLVIGTDGITCVTPPACDTLSGATFDPTTVTCTCSSPLVIGTDGLTCVSPPACDTLSGATFDPTTVTCTCSSPLVIGTDGLTCVTPPACDTLSGATFDPTTVTCTCSPPLVIGTDGITCVTPPACDTLSGATFDPTTVTCTCSSPLVIGTDSITCVTPPACDTLSGATLDPTTVTCTCSSPLVIGTDGLTCVTPPACDTLSGATLDPTTVTCTCSSPLVIGTDGITCVTPPACDTLSGATFDPTTVTCTCSSPLVIGTDGLTCVTPPACDTASGATLDLTTVTCTCSPPLVIGTDGVTCVTPPACDTTSGATLDPTTVTCTCSLPLIIGTDGLTCVTPPACDTTSGATLDPTTVTCACSSPLIIGTDGLTCVTPPACDTTSGATLDPTTVTCTCSSPLVIGTDGLTCVTPPACNTASGATLDPTTVTCTCSSPLVIGTDGLTCVTPPACDTASGATLDPTTVTCTCSSPLVIGTDSLTCVTPPACDTASGATFDPTTVTCTCSSPQEIGSDGVTCITPIACNTASGATRNPNSNTCFCGFPVVGTDSVTTQVLQTDGITCRTVVSFTPGTTPAAIGTAALAKAPTDGESNVAFGFQSLTIGSAGYVGQASRQLIAFYSTGIAAKCIACVTVGYMLHIPSGLCVTAIATSVTTPQYPGAGTQLQLCDITDPQPLDNQLFCATVATSASSCAVRFQFQGDLTSGCPYASGNGVGLESMTYPCGSYWTYNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RI59</accession>
    <name>A0A3D8RI59_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_07174</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RI59"/>
    <dbReference type="OrthoDB" id="4186058at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="74"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW73732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="303" mass="34009" checksum="CA9F8CCF50BA4ED4" modified="2019-01-16" version="1">MRPQTPEMSFTQPTAPSSPPETPTSPTFNIGRQRRHGIQSFAHISRTLDDTLRAHRDGYHFSHNRFSRLEDLSPRSSSPSSESSGSGCPPRSLSSARSASPEPSEQGRSSPPPNYTQKANFTVEEITESDIEDMNSDDEDIIRPYHYEDAESDHPRSWKAASELDPHVVSALRHLDCDDPDSDMDEHLAQIEAMRREKRRKRRSSGSVKRTHGESVGSGTDEDDMFAPQLDAGEAGSSARRLRRKTDRSSLIFDDPPPRIEEEEEPESCEELVEVHDDDTEGQGVDKNLPYYIQEMDVDSGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RI92</accession>
    <name>A0A3D8RI92_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">(Trans)glycosidase-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_07205</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RI92"/>
    <dbReference type="OrthoDB" id="9971853at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050295">
        <property type="term" value="F:steryl-beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904462">
        <property type="term" value="P:ergosteryl 3-beta-D-glucoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000131">
        <property type="entry name" value="Glycoside hydrolase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000106">
        <property type="entry name" value="Glycosyl hydrolase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041036">
        <property type="entry name" value="GH5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018087">
        <property type="entry name" value="Glyco_hydro_5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052066">
        <property type="entry name" value="Glycosphingolipid_Hydrolases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31308:SF5">
        <property type="entry name" value="ERGOSTERYL-BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18564">
        <property type="entry name" value="Glyco_hydro_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00659">
        <property type="entry name" value="GLYCOSYL_HYDROL_F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="5">
        <location>
            <begin position="70"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5 C-terminal" evidence="6">
        <location>
            <begin position="643"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="555"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="605"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW73763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="763" mass="86661" checksum="E76EBB6F8641E7FD" modified="2019-01-16" version="1">MAPLRLTIEKGEFRDSQGRHVTLRGINMAADAKYPSKPDQPSHIADDFFDGDNVNFHQRPFAVDEAHIHFSRLKRWGYNTIRYIFTWEAIEWAGPGKYDEEWIRHTIELLRLARDYGFYIFMDPHQDVWSRFSGGSGAPMWTLYACGLNPQGFAATEAALVHNTYPDPATFPKMIWSTNYARMANQLIWTMFYAGRDFTPKCIIDGKNIQDYLNDHFIAAMGHLARRMHEAGDLEDDIVIGWETLNEPNRGLVGHQDISKIPPEQQLQKGTSPTAWQAMLTGSGRACEIDTWDFGGLGPYKSGRVLVDPQGVSAWLPADYDDSRYGWKRDPGWKLGECVWAQHGVWDPKTDTLLKKNYFSCIPSTGEKLDYEEFTNKYFMAHYRKYRDTIRTWHKDCILFCQPPVLEIPPSIKGTEDDDPKMVYAPHYYDGITLITKKWNRYWNVDVFGVLRGRYMSPAFAVKLGETAIRNCFKDQLTAIRQEGEKYMGVHPCVMTEFGIPYDMDDKYAYRTGDYSSQSAAMDANHFAAEGSGMAGYTLWVYMCQNNHQRGDQWNGEDLSIFSTDDRPLPLSPLPPSPTNVSSASLIPNARSPGKKEFSDDATVTPGNLKQSLKTPSISSEQSNTPPELTNAPGFRAAEAYVRPSPIATVGKLVESGFDLRNCVFTMKLFAAKPGVEDTPTEIFLPEFHFPKDKCEVEVTSGKWSISTDDSDGGIIQKLRWWHVEGEHSIKITGVQRRQNMALGKEEEEGYLDQCQQTKCSIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIT1</accession>
    <name>A0A3D8RIT1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 12">Dihydrolipoyl dehydrogenase</fullName>
            <ecNumber evidence="2 12">1.8.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BP5796_07322</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + NAD(+) = N(6)-[(R)-lipoyl]-L-lysyl-[protein] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15045"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="1.8.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="10 12">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="miscellaneous">
        <text evidence="12">The active site is a redox-active disulfide bond.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.4" evidence="2 12"/>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIT1"/>
    <dbReference type="OrthoDB" id="361797at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045252">
        <property type="term" value="C:oxoglutarate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045254">
        <property type="term" value="C:pyruvate dehydrogenase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004148">
        <property type="term" value="F:dihydrolipoyl dehydrogenase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006103">
        <property type="term" value="P:2-oxoglutarate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.30:FF:000001">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000025">
        <property type="entry name" value="Dihydrolipoyl dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050151">
        <property type="entry name" value="Class-I_Pyr_Nuc-Dis_Oxidored"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006258">
        <property type="entry name" value="Lipoamide_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01350">
        <property type="entry name" value="lipoamide_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912:SF151">
        <property type="entry name" value="DIHYDROLIPOYL DEHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22912">
        <property type="entry name" value="DISULFIDE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 10 12" id="KW-0274">FAD</keyword>
    <keyword evidence="3 12" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6 10 12" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 12" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="14">
        <location>
            <begin position="46"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="13">
        <location>
            <begin position="390"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="488"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="185"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="222"/>
            <end position="229"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="362"/>
            <end position="365"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="11">
        <location>
            <begin position="83"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDW73880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="509" mass="54187" checksum="DC60CEE3D3F05110" modified="2019-01-16" version="1">MLRSLLVPRVAARSFKQSSSLPSVVAPASIARLSRRSYATETEQQDLVIIGGGVAGYVAAIKAGQEGLKVTCIEKRGVLGGTCLNVGCIPSKALLNNSHLYHQILHDTKARGIDVGDVKLNLTQMMKSKDTAVAGLTKGVEFLFKKNNVNYVKGTASFTGEHEVKVNLSEGGETSITGKNILIATGSEATPFPGLEIDEKRIVTSTGAIALEKVPETMTVIGGGIIGLEMASVWSRLGAKVTVVEFLGQIGGPGMDAEIAKSAQKILKKQGIEFKVNTKVMGGDASGEKIKLEVEAAKGGKQETLESDVVLVAIGRRPYTAGLGLENIGLETDDKGRMVIDQEYRTKLPHIRVIGDCTFGPMLAHKAEEEAVAAIEYITKGHGHVNYGAIPSVMYTHPEVAWVGQNEQELKASETKYNIGTFPFSANSRAKTNLDTEGMVKILADAETDRILGIHIIGPNAGEMIAEGTLALEYGASSEDVARTCHAHPTLAEAFKEAAMATYSKAVHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJ12</accession>
    <name>A0A3D8RJ12_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_07474</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJ12"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017000">
        <property type="term" value="P:antibiotic biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.130.10:FF:000009">
        <property type="entry name" value="Putative Taurine catabolism dioxygenase TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050411">
        <property type="entry name" value="AlphaKG_dependent_hydroxylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696">
        <property type="entry name" value="GAMMA-BUTYROBETAINE HYDROXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10696:SF56">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0045">Antibiotic biosynthesis</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="4">
        <location>
            <begin position="98"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW74032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="401" mass="45339" checksum="E4CF163359B41E33" modified="2019-01-16" version="1">MAPSILDSQPTAPHELSSPAQKTVDKKIFPDGIKTSGQHPPLPEYIKPYSDFPKEIRGETVWKAEDYKNNPERWVHQFTAEEISELNDAANKYLSDKTPLTAISQDNFKLPNFSTTLKAIRSEIINGKGFILFKGFPVDEWGTHKSAVAYMGLGTYLGYFVSQNGRGHVLGHVKDLGDDPTAIHRVRIYRTNARQFFHADDSDIVGLLCIARALEGGESDIVSSHHVWNTLQKERPDVAETLTKPIWYFDRKGEVSKGEEPYIKTSVFYLEKGPNGRVYSKWDPYYVKSLGRFSDAGIIPALSPEQVDATQVLEDTCLRLSLHMILEVGDIQFVSNEHVLHARTEYKDYPPPAPRRQLMRLWLATPENEGGWKLPFHDSHEKKRGGIQVNDQPPVCPLDAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJ21</accession>
    <name>A0A3D8RJ21_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Golgi apparatus membrane protein TVP38</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Golgi apparatus membrane protein tvp38</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_07491</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Golgi membrane protein involved in vesicular trafficking and spindle migration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TVP38/TMEM64 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJ21"/>
    <dbReference type="OrthoDB" id="166803at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000022">
        <property type="term" value="P:mitotic spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051076">
        <property type="entry name" value="Golgi_membrane_TVP38/TMEM64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032816">
        <property type="entry name" value="VTT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47549">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09335">
        <property type="entry name" value="VTT_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="123"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="VTT" evidence="12">
        <location>
            <begin position="142"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="359"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="364"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF09335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW74049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="391" mass="42332" checksum="4E01A0E2119776D4" modified="2019-01-16" version="1">MPADYSSTAKALALPISPIGSPSLDSQTRRPVWTRAASSRRTISASPYSQTASSYQKQIIQSAKKIKRTILQTWRQLSVLQRIAAVLAFTTLQVLVILFLIYNEKIFSSLAPLAEKWHDVRGGWTILWLMTFICAFPPLIGYSTTITIAGFVYGFPNGWFIVASATVAGSTASLIASRTVLSKYVDRLVGGDKRFEALALTLKHDGIKILCMIRLCPLPYSLSNAAISTFPTVHPLSYALATAIVTPKLLIHVFIGSRLAALAENGGKMDASTKAINYASIIFGAVLGAAVGWIIYSKTVSRAKELEEEELAATRGEQAAASSRTGAYHDGDIDDGTDAAVSMNDDDISLWDNDEGNLTYRDDFTDDEDNPFSTGDLDEEASVGGQGQRKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RNA8</accession>
    <name>A0A3D8RNA8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_06403</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RNA8"/>
    <dbReference type="OrthoDB" id="407442at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12347">
        <property type="entry name" value="RRM_PPIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034168">
        <property type="entry name" value="PPIE_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037">
        <property type="entry name" value="ATPASE E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48037:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="9"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="116"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="131"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW75582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="153" mass="16423" checksum="46664954FD9B5757" modified="2019-01-16" version="1">MTDQARWKATVYVGGLAPTVTAANLEAAFIPFGEIADVSLPKPEGPNSTELHRGFGYVEFEDPEDTKDAIENMDQSELFGRVIKVSTAKPPKNVNEGLGSKTALWEQEGWLAENAVSEEDRAAAESARAGANDRPDDPMHGLEGLDVAGPQRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVN0</accession>
    <name>A0A3D8RVN0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="9">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_05888</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="9">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7 9">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="9"/>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="26387at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16482">
        <property type="entry name" value="RING-H2_UBR1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19673">
        <property type="entry name" value="UBR-box_UBR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.30:FF:000001">
        <property type="entry name" value="E3 ubiquitin-protein ligase UBR2 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055194">
        <property type="entry name" value="UBR1-like_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF24">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22960">
        <property type="entry name" value="WHD_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="11">
        <location>
            <begin position="89"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="8">
        <location>
            <begin position="89"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="426"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="484"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1660"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="429"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="488"/>
            <end position="501"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW78036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="2137" mass="242503" checksum="53790191E5D717DA" modified="2019-01-16" version="1">MNETNLSTPELQLCEFLKSLPRVKQNRYDEAAERELVYNLFWSLAGGQERYMRLIFPEGRRPRNNELWKLRKAQGGTDGDEFTEAARGKACGHIFKAGEATYRCKTCSADDTCVLCSRCYDSSDHTGHMVYVSVSSGNSGCCDCGDPEAWRLPVHCSIHTAHEHEFKAAGKAKEAVGLPDELVESIRMTIGRAFDYICDVISCSPEQLRLPKSVESIKQDERMSRLTSSYYNGDIVEEPTEYALLLWNDEKHTVNEVRDQVARACKTTISEGLKRAHETDDIGRSIIKYDTDIENLLRVSKIIEQIKVTVTIRSARDTFREQMCGTIIEWLSDIAGCSVGQDHNILRQVICEEMLKEWHAGSEASNKTVGRDGLDDHEIFDASDYRRMLVSRQAEVLRATATAAAAEAQDDSDDSEDGDEGTIERLIIIEDDDDDDDDEDDDDDPETYMTIETVIAAPRQNVDTDGDVDMTDQDDAALEVQEATMAGYPPPPPPPPPPPQRPIRDRDITPSDSDTAEPLIPSTVYAKANLEIPKTPKNPARAPEHPKPPRYWLETPQAFSERDEIPLHEDLWKRVRLDWMILFDLRMWKKVRIDLRDLYISTVVTIPQFKRVLGLRFAGLYTTLAQLYLIADREPDHSIINISLQMLTTPSITAEIVERGNFLTNLMAILYTFLTTRQVGHPHEIFPNATLAFDSGSVTNRRMYHFFMDLKYLFSSEHVQERLRTEDRYILQFLDLVKLHQGICPNTRAVGEHVEYETDAWISASLITREINRLCRQFSESFIWSPGENSSSIQRAIMLTAKAVILSSLGSERKRFTQAEIKDEIKFKRVGDYEFDTSGTEYTVVKFVVEEQPISFHHALHYTLSWLIEGGKSMPREELIRLLSFSSHDLASKPKAMGPRTMPSHSYTPEDHLMAAFDYPLRVCAWLAQMKASMWVRNGMSLRHQQGTYRGVSQRDVSHHRDIFLLQTALVVCSPSRVLASVIDRYGMQYWMKGLYEQKSDALDDTQLLDVAEDLIHLLIVLISDRTSLLSAEEEPNPQLVAMRRDIIHVLCFKPLSFSEICGKLPDKFQDHEESQDILDDMTTFKAPEGLSDVGTFELKEHFLEEIDPYIAHYNKNQREESENAYKTYMSKKTGRPVSEIVFEAKLRPIQSGVFSELSSFTGTGMFAQIIYYALLYPLKAQELTPSVPATRVEVFLHVVLHLVLIAIAEDKTGEEDMIDNSEQSFVHIALTRNARSNFIKNAPAAKTIVAILEMMSTKDIFKSCHPKILLVLKRMKQKRPRSFDTAFQRLGVSVDRVSTASPANADNGFEDREKKKRAALARQAKVMAQFQQQQKNFLDNQGDIDWGEEDMSDEEVKVEGEEPKQYWEFPSGTCILCQEECKDGRLYGTFALMTQSSLLRQTDFDDPDFVREAASTPANLDRSAADIRPFGVAGENREQVHKVTASGVDIITERQFIGKGFPKTAVRPGPVSVGCGHIMHYRCFEQYYEASQRRHQHQIARHHPEGLGLNEFVCPLCKALGNAFLPVIWSGKQEIYPGPLVPSTSIDYTLQRAFSTSRPENIRAERLGNAGNASQNHQNRSLTLYMDYNMTAIVGPISSKASELLMDAWGPLSPQASTPFTGPSMRLPGTFEPPNSDYNTPPSAMRELVNTYRRLKDTMSKNKLPTHHSPEERLSSDELSGSDTLAQMLGFSISTVEIAQRGVASQPGLTLLDNIPHNALTHLRVLSETALSYVSIGGIRSAGDNRVSREFCTDYELQYFQLFGRSPYNEPNHEQYKELLEAYDSMLNSDIFVTLTQFSLCLAPIDEFDIMHIVRICYLAELLKVVVEIARHRDVEQYALEVVIDNPFKSFATMVWRFRKGWNQGFGTTSFEGFASARELVRKYALAFLRKVVVLLHVRYGVAFQHHISSDPDADELDRLTEALRLPSFDTLCDEASSGENKHYHSIIIHWMTHFYYANRARVTTVSHPAIFELLGLPKNYDTLMEETMKRRCPTTGKDVSDPMLCLFCGDIFCGQSICCLKDAPREPGEPRSSTVKKIGGAQQHMLKCQKNTGLFINIRKCCVFYLYHQSGSWMVAPYIDKYGEVDPGLRHSRQLFLNQKRYDALLRTVWLTSGVPSVISRKLEMDINNGGWETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVQ8</accession>
    <name>A0A3D8RVQ8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vezatin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BP5796_05999</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell junction</location>
            <location evidence="2">Adherens junction</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the vezatin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVQ8"/>
    <dbReference type="OrthoDB" id="21151at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017022">
        <property type="term" value="F:myosin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098609">
        <property type="term" value="P:cell-cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026859">
        <property type="entry name" value="Myosin-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026858">
        <property type="entry name" value="Vezatin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15989">
        <property type="entry name" value="VEZATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15989:SF5">
        <property type="entry name" value="VEZATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12632">
        <property type="entry name" value="Vezatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0965">Cell junction</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="168"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin-binding" evidence="15">
        <location>
            <begin position="146"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF12632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDW78147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="605" mass="67717" checksum="ECD9B0F0FA8A6188" modified="2019-01-16" version="1">MESVVFEASPLAEYLEGEGGDNSEWASNREEPSPTPSFAPRGKPAVRSKFRQKLPPGLRLVVPQNTVVATIHNTCSRAVNSRLGRVDNERFLERFRYIVVASQLLSTHSYLSQGQHGQSRELPVSLPSAPQLGPFTFTGACATACLAFSLVWLIHWARGGADSVVGRWRMALVLALMLVLAFVSYTYIRRQWLQYLRQQTLLEASEYVSKAQAFDNVAAAALTLVQEVELVSRGYRISAPLPPVSRLEDRSQTRRCIRLRKTLRLCFAEMIPRYQQAFAALKPFADETNLEKYYDVYDISDMDFSEAMLDYTEAEFADQDSLRVLKILAARLHTARKVFLSCLLALDAHGGKPDFIRWSTAVDELHGVASVACVIEERFRSILTDEETFAVPSTPKLPLSPNHERSRAQLRKLSSLSTGIRGLQAKLHVLRDESDKNLSEAGDVSEFGTNLMIQYESIGMDLKALMQEWEDGKTVLAFNIDKHERRISSISGMLSPTTSLGGLTAVEEGGALEALRALNGEDRSRSSMDLSSSDAEEVFEAVALPRQRSTLTREERIVKMKEDRAKRESMRERVDANTHMLRELESVINLRPRGRTTAGGRITSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVS9</accession>
    <name>A0A3D8RVS9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">60S ribosomal protein L33</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_05938</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVS9"/>
    <dbReference type="OrthoDB" id="1166329at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.190:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.190">
        <property type="entry name" value="translation elongation factor selb, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00573">
        <property type="entry name" value="Ribosomal_eL33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001780">
        <property type="entry name" value="Ribosomal_eL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018266">
        <property type="entry name" value="Ribosomal_eL33_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038661">
        <property type="entry name" value="Ribosomal_eL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10902">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01247">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01105">
        <property type="entry name" value="RIBOSOMAL_L35AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW78086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="12165" checksum="85A7BAE9A20D799E" modified="2019-01-16" version="1">MSSEAGHRLYVKGRHLSYQRGKRTTTPGTSLIKIEGVDDTNAANFYLGKKVAFVYRASKEIRGSKIRVIWGKVTRPHGNSGVVRAQFRRNLPPKSFGASVRVMLYPSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVW6</accession>
    <name>A0A3D8RVW6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_06059</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVW6"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW78207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="93" mass="9617" checksum="D4BBD8651F0F98D8" modified="2019-01-16" version="1">MLHGVLHGPSIPIHNKTTAAAKPPKIPAPIPATFPAFEVAVADVAEAVADDLREEIEEAVEAALDAPDDAAPAPDVAVAVVLLDTQETLDARH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RW86</accession>
    <name>A0A3D8RW86_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_06098</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RW86"/>
    <dbReference type="OrthoDB" id="10415576at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW78246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="401" mass="42035" checksum="A70DBBE0A9103291" modified="2019-01-16" version="1">MLTRTPTEVIPCVAPPPPPPCHMDTSALPPAPPRLAYGHCTPAQARWAAEAARVWSQSLPSLPDTVYNPWAVCSVCNQFVYTQYEGIEGDKIVSDGSPLGLIPDAFALHTYRLLPSDLQESTTVVSVVTPSANGPPSSAGPLFDTSVEQALNVPYPTEASTSTVTSPGNVTTSRVKRGLSSTPSLPEAPDVDASNIRRSKRAKKPPASKFPPGSEAKPKPPASIPFQPGTIPVKRGRGRPRKYPLPAPPLGPTPLAQPSSTATHLQDALSDGKPGAVQKQADVQEPTQAGPTSQPEGKPVQARSQARGRAAKAGGPQAATPGSACWLSAVATGVAEAILAPDSGTQEGREAIYGLGEGLGKQLIEELDRRGIGNEQVKEVTEAWTQGVFRGMWFHGGLESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWK5</accession>
    <name>A0A3D8RWK5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_06162</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWK5"/>
    <dbReference type="OrthoDB" id="5401779at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF55">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="17"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="240"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="31"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="274"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="274"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW78310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="372" mass="41485" checksum="D0BC5D49AFCFC61A" modified="2019-01-16" version="1">MTADLSDIHHADYEKEACIIFCVIVPFFVFVRFWSRILAKQLGSDDWAALISLFTALCSNIQTLVAISYGWGRHKQNLNKEQLRIVLILHWTFQITYKLTVAFNKVSILLLYLRIMPQRAYRMTIYGLLITVGLFSFSTSIAGILQCVPVAKAWQKNMPGYCYDLVKAWYANAIFSIITDIAILCLPMHMVYKLQRSRREKFLLYGIFGIGAFVTFTSIMRMFALKSAKNPDVTYDVNSGFWSVIETNVGVICICLPPLRSLITKYVPNFGTTRSGRSGGSKSSYPPPSYSNSTPVQNTIGGGPIEGSWGTARVRGSAGDSEEELVADLEGNLSDRGGIRKTMEVHLTTGGVEDAGEIELGHWSKSDVSKQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWM1</accession>
    <name>A0A3D8RWM1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DUF803-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_06331</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWM1"/>
    <dbReference type="OrthoDB" id="165382at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF65">
        <property type="entry name" value="MAGNESIUM TRANSPORTER NIPA9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="368"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="93"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="444"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="392"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="448"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="475"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="493"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="530"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="591"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="619"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="652"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="671"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW78479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="707" mass="76333" checksum="C0F5E3B1A66CF8EE" modified="2019-01-16" version="1">MYLSTTVLDAASATSFSTPELVRMATPSSFDPSSYTAQGDSQLQRWSSLIGIITAIVGNILISFALNIQRYAHIQLHKERIEQREKFKALSKGVNNGYGSTNNRDGISDGAENGGEDPLRQSFQSVDSQATTCSDGDSKVKSTSYLSSPYWWGGIVLMTVGEAGNFLAYGFAPASIVSPLGVVALISNCVIAPIMLKEHFRMRDFWGVVVAVGGAVTVVLSAKQEEKKLGPHEIWDAITAMPFEIYMGVTVSLIVVLVWASPKYGSKTILVDLGLVGLFGGYTALSTKGVASMLSYTLWRALTTPVTYALLAVLMGTAVMQVKYVNKALQRFNSTQVIPVQFVMFTLSVIIGSAILYGDFYQATADQVGKFIGGCLLTFFGVFLITSGRESMDDDSSDSEESSDEEEELNVDIVERDHFEAEGPYHDHPDQNGTRRRFSKADIMANGDATNDTASGSRRSSRVSFADPVKRPGTSRLYSSSSQQPSIRLIPSGTNPDPASTSESSPLLANPWRSPADDLLQSRHPGMPASVSSPILPSEAQLPSTDSLKPSPHRGSSQSNFHTHPNQQGPSPPQAERPSTPVRHSMAKLMPGPLLSPLSGGLSAVVADSLRRGVDNHQKSKRLRRSKSQTHRLANPSEDELGTSPLKKVDTAQETPSLSKSLGNDTGPWTRVSRSRSLSSTIGDLFRVKKQKLDEDEVDEEAGPSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2C2</accession>
    <name>A0A3D8S2C2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_05145</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2C2"/>
    <dbReference type="OrthoDB" id="66881at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050775">
        <property type="entry name" value="FAD-binding_Monooxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43098:SF3">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="8">
        <location>
            <begin position="19"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW80447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="573" mass="64897" checksum="E073C1F26ECF127D" modified="2019-01-16" version="1">MTPIATSDINTSSGSNSLDVLIVGAGFGGLYQLHYLRKLGFHCKVVDNASELGGIWYWNCYPGARVDSDIPLYEYSIEDLYKDWTWSERFPSWSELRRYFAYVDKKLDLSKDVILNTGVVSADFDTKTSRWNVHLSTGETYDTKFFVLCTGFAAKRHEPNFKGREKYEGICHHTAVYPQEGIDVKGKKVAVIGTGASGVQCIQEIGPEVSHLTVLQRTPNLCLPMCQKKLDPKTEATEKENGNYQKIFDYRRDTFGGFHFDFAKRDGNEDTAEQQREFYEKLWNGGGFRFWLATYQDCLFDKSVNDTAYAFWAEKTRARINDPVKKDILAPLLEKQHHTFGTKRPSLEQRYYEVYNQDNVDVIPLKETPIDTFTEKGIKFKDGKELDFDIIILATGFDSVTGGLVQIDIKGTDGVSLADKWSKGTWTNLGMTTAGFPNMFFLYGPQGPTAFANGPTIVELQGDWIVRCIKYVHEHNHETIDATAEAEALWTKHVAELCDKTLFPGTDSWYMGANIPGKPRESLNYAGGIPRYVRECREKEDKGYEGFIFDKSYGIGKGEVEDVASQIKNIEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2F8</accession>
    <name>A0A3D8S2F8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AAA+ ATPase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_05185</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2F8"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054289">
        <property type="entry name" value="DUF7025"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411:SF1">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05752)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46411">
        <property type="entry name" value="FAMILY ATPASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22942">
        <property type="entry name" value="DUF7025"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="2">
        <location>
            <begin position="741"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="70"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="589"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW80487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="963" mass="108691" checksum="C06D56C30FFF416B" modified="2019-01-16" version="1">MDTPITSTSGDVTERREEETPVVSEGGSGTQVDTKQRQATDCSPKIKSNKLKAKENVAKAGKVKSKVAKPELSSDSDSSDSSSESDSDDSVSSSSGSDSDSESETEKEKRKRKAKKKAKQKAKEKKKAKSKRKSKKAESSDSASESSDDSEPASDPESDIESEQDETVDDLALQQKLLQLQIQQQQLQGLNNAGIQANNWSLPPPRASRLSRQQVARNARQLAALGSLDRKSRKKAKKEKGSKNKRGSRLEFKRVDQLWDSTIHNYKLTDTNEDDESSEYDQYLFNVRRTFDWEGKYKATLVDIKSKLLKEALNDVMDGVKGVSLVEETPKVDPNLMFLYLEDLRALHKELKNKKVTVKKGKKKAKKRNETKRKHIKVLLKYLDKDYASTKKTLYPMLESGLITFDLLWALYKPNTLAYTTTYGSVEEPRAFRIELAEKEFSFMKGEWYNIEGKYLEYDGKSWGMGTMDCDVPAFKGARKITSLNCYPLKYHKNEAKLRLELIERGKKFVSLQGVHYKSHEGMAYTKKRKQIIKVNINGRIMVDPAIHRRILPNYNISTVKPKDPDLLDSSDEEQDSDDCCGCNESSDEDNRERGLEDKKDDDDEPKLKLKIVLDEKKEPHIVEVPVDADGNEIVAEKLEEVPSKMGKNYEAETQEDKKALPTFSEEEYLIASPVVLGFAFAEKLWLEFTVSGIKDIVWNEGAYDSLVLENNTKDIVRALVESHKYHPAESIDDVIQGKGKGLVAVLHGPPGTGKTLTAEGISELLKCPLYMVSAGELGTDPRTLEGELQKILDIAHAWGAVLLLDEADVFLEKRTIQDIHRNALVSIFLRLLEYFQGILFLTTNRVETFDDAFQSRIHVALRYGALSTKAKKSVFKLFIERVRVLENVPTMPFTEADFDTLSRHNLNGRQIKNTIRTAQALAVNKQEPLSMEHIKRVLDVSNAFDRDLKGGTGFEDAMNSYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2J4</accession>
    <name>A0A3D8S2J4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_05186</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2J4"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000024">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF67">
        <property type="entry name" value="MFS MULTIDRUG EFFLUX TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="198"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="397"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="433"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="462"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="488"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="534"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="596"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="132"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="76"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW80488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="627" mass="67616" checksum="34B2D18A3FABB18F" modified="2019-01-16" version="1">MATNPHPPNERTSLLAAGPDSQYNAANNMEVAVEDDEQREIDPNAFDIMLSRSNSITAGLGIETESQETAMLRGPRTYGAAKRRSSNNSRHRRKSFASTISGEAISEQDEMEEAESKSPYLAGVSVGTFWLIFGNVLASFFVACFDSTIMVSSHPVITSYFHSSNSASWLSTAFLLTSTSFQPIFGRLSDTIGRKRPYVLTMGLFTLATVWCATAQSMTSFILARAACGLGAGGMMSLGSIIISDLVPIEIRGEYQSYVNMVFGAGSALGAALGGAIADHLGWRWEFGVQVPALSLCLLIACLTIPKNLGLAEGVKQKNIWEAMKVFDYWGSLLLTTSITFLILGLNLGGNVFPWSHPFVIASLAIFAVGFPLFLWNEAVVALPIMPLKLISSNPRAGLIMSNAIGAIVVNAVMFNIPLYFQAVLLESATNSGLRLIVSSLASSAVGTATGFLITWTRQLKIWLVAGATLVTIGTICMTFLRRDLPEWAYVLVLIPSAMGQGFMFPGTFMSVLAVSEQAEQAVVTSTLILWRSLGMVMGVATSSLVLQNALYVFLEEKVSGPEKAKVIEEVRASVHAIAKLAQPYQEQVIQSYDSALRATFMVSAVLSVIGLLVVLPPRLPKLGQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2T3</accession>
    <name>A0A3D8S2T3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative magnesium-dependent phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_05283</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2T3"/>
    <dbReference type="OrthoDB" id="2865258at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07501">
        <property type="entry name" value="HAD_MDP-1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000155">
        <property type="entry name" value="Putative magnesium dependent phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010033">
        <property type="entry name" value="HAD_SF_ppase_IIIC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035679">
        <property type="entry name" value="MDP-1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010036">
        <property type="entry name" value="MDP_1_eu_arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01681">
        <property type="entry name" value="HAD-SF-IIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01685">
        <property type="entry name" value="MDP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901:SF14">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17901">
        <property type="entry name" value="MAGNESIUM-DEPENDENT PHOSPHATASE 1 MDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12689">
        <property type="entry name" value="Acid_PPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01131">
        <property type="entry name" value="C1.5.2:_MDP_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01129">
        <property type="entry name" value="C1.5:_HAD__Beta-PGM__Phosphata"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW80585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="212" mass="23898" checksum="3459C2312B9196F4" modified="2019-01-16" version="1">MPKKLSKTPTSGSIASHESATGPETFNDGLPLPRMMVFDLDYTLWPFWVDTHVTGPLKATPQNDAVKDRYNESFAFYSEVPGILAALREKDIKVGAASRTSAPDLARETLRLLHIVDVDGKKKKSIDFFDHMEIYPGSKITHFNKLQKATGLNYEDMLFFDDETRNRNVETLGVTMYLVRDGVNKAEINNGVKEWRKRHGHVKPAGTTSKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2U7</accession>
    <name>A0A3D8S2U7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SH3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_05320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2U7"/>
    <dbReference type="OrthoDB" id="207120at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd11887">
        <property type="entry name" value="SH3_Bbc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057402">
        <property type="entry name" value="AIM3_BBC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035552">
        <property type="entry name" value="Mti1_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050670">
        <property type="entry name" value="STAM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929">
        <property type="entry name" value="JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45929:SF7">
        <property type="entry name" value="LAS SEVENTEEN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25459">
        <property type="entry name" value="AIM3_BBC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="SH3" evidence="4">
        <location>
            <begin position="3"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="45"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="215"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="237"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="272"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="294"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="340"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="421"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="447"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="464"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="573"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="591"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="654"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="717"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="736"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="752"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="796"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="820"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW80622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1150" mass="124281" checksum="2D3849C3097ADDAA" modified="2019-01-16" version="1">MSAPPFKVKAVYEYTSPHDDDLHFPNGQIITVIEEEDEDWYVGEYVDTSGTKQEGLFPKNFVEKYEPTAPPRPTRTARPKKEPEPEPVVADPLPEPEISHSEPAPTEVAAPEPEEEAEEPQTSPAVREPPPPAPRAEVAPAPKAAEPVSPAMTPSAPKSVPSTKPAAPPPVSEKPSGNSFRDRIAAFNKAAPPPAPFKPGGLGSGSSNFIKKPFVAPPPSKNAYVPPPREPAPQKIYRREEDPEIAAKESEDRELAERAGLAPANNEDAEEEQPKPTSLKERIALLQKQQMEQANRHADVAAKKEKPKRPAKKRTDSQGPPEAEGGEMTGIERQITGDTIGKKSMDSTREDLNPRIAPRRKSSSRPAVPMPVSDPKSFGDGNEADMSGAGETTEEPEEMSDEKPKSRPAAPARAPTHEPDVGEEEGAIEEEAPLEEEEDEEEDDVDPEVRRKEELRARMAKMSGGMGMHGMFGGGMPMPMPMSAPKKKKPSISSERRVVDEGEEASPSARAPPVPMIPLPGLSRRKTSEPVEGEDEDAPVTSTRPAEEVPDVEDAVAQGSPQAVSSHEAGGAPPIPSGRPAPPPVPKDTRPAAPSSMLMSPSAGSESDDEMSVKTQRLSLATPTAERPPPPPNRPLESSPRSPTSKRASFFGAESTSPADSTPNRRASRVPPIPGAVLASPAARAPPPPPPGALSRTSTGDQRPSPPAPPVTHQESEGEVTEYDGDYDTDIAPTAPHKDALKSSKDEDSAPARPPVHSPTAAPPPLPPVAAPRAIPPPLPSQPPPPARQSVDMPRAAPPPPPPAAGPTYDEGDDEYDPYNYTSPKVLSPSLGTLTPRTERIEEDLYGASPPRSYASPPLPSRDAAPPKQPPRKSTDMQRATGTRRSVELSRMSMDSGYVANDVDLAQSSVWWTQPNGIPPAFQNRKDLLHESEQATSKRDGIVTKDVYVLFQDYSQTIITVKFDPQNPSDAVLEQRHEQPPSRLRQDQLEQAHEQFGRKVYEAVTSKQNTIVGDGTPQGLVQELLKPFADALLPVGTRAYGALVYGNLANASTQQNDEIRPGDIITLRNTKFQGKHGPMHAKYSAEIGKPDHVGVVAEWDGTKKKVRAWEQGRESKKVKLESFKLDDLRSGEVKIWRIMPRSWVGWEGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S302</accession>
    <name>A0A3D8S302_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_05381</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S302"/>
    <dbReference type="OrthoDB" id="5575144at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050335">
        <property type="entry name" value="ERT1_acuK_gluconeogen_tf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47659">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="180"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="38"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="217"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="486"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="458"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="569"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW80683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="604" mass="67481" checksum="837BF37DDBB03E36" modified="2019-01-16" version="1">MQSLSNRSEQSNISLGERRGKSDLARFSLDLSWARAVSHGARSRAYPSPPMSGSPPLPPRRNPESSDRDHGSYGPGQDVFRSTLTPQLEPSRRAGAPLRPYQPELQHTAYPQAQMDDSAARYQYQQVPQQMPPQQQYYTAHPPPQPAQQYSVSARQPILEASDHSSPKAQRKTKGHVASACVPCKRAHLRCDAQRPCSRCLSNGKEDTCIDVQHKKRGRPRLRDERDPRYENVGPGFQTPPEGLRRPLSLYGPSDGPSMSSQFGETLLQRSGSYRVLKSQGGGGSVPPRYPEHAEAIYAAALPPQPAAGPRIMPPQEPMCAYLTMDLQIAKATQAFNDAIGVQSSAARKLHDIVGPNDRDKVFRLQRIFEDERREREPNYLPPIYLKYEEDRVIQSVGFGPEEMSQFQANRPEMFTFQGPDGQQRTFHVRFGLAKKDSTYFIVFVLHIPATPQTYHQPSSSPYSRESYSRDSQYGYQTPQQAFAQAPNVSPYGQNPPFGDPRGEHLGYRPAPAAGVIVPPMPPASHPYAQSQARPEFAPTQHPYQTPRSELPPQGQAPPQHGLQLPPIRDQRVDTSQSDPRRRDDRSGRVDIGGLLEKPDASRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3J4</accession>
    <name>A0A3D8S3J4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MFS general substrate transporter-17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_05557</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3J4"/>
    <dbReference type="OrthoDB" id="2587356at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06179">
        <property type="entry name" value="MFS_TRI12_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053791">
        <property type="entry name" value="MFS_Tri12-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF195">
        <property type="entry name" value="PEP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="100"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="303"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="392"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="514"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="27"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW80859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="559" mass="59328" checksum="C0012CBC2DA24F44" modified="2019-01-16" version="1">MTPPPELYGQPRKAESDIEVIQTETAQTNPTSLVDLDVYEDSSIMAQVFVVVAAGSVIGFIIRDLGEASIAGWIIQGPLLMQSVLSPIVGRLSDTLDRKYLAAIPPLIAFAGAVISAKASSMTMLIGGGILIGTTLSTISIVQAIPSEVLPLKFRPLANGFAFLGGALGGLIGSLGAGAATNASSSGWRNIFWIQAGFHVTTAVGIFLFYWPPKKSSECSKMSWKKVIWSCDPIGSLLFVVSATLMLLALDWAGGAYAWKDPHVVANLVIGLVTMIGFGLYEWKVRDDGLVAHVFFKDNWNFPFWIFYSAVNSVTPLIVLNLGFETDAWKISIRQVAYTLTTLVASIPITLYSTWRKDLKSPLLLTFTLFLVVTICYCTITPSMSKAQIGFNVLSGLGQSGPLTLLIALVQFTAPHAYLSTATGLAFSARALGGAYGSAVLNTIINGKLASSYAPKVSSAAVMAGLPNTSIETLLLALAAGSTTAINEVPGMNEKILAATMTASHNAYANAYRLAWASIVPFVILALAAVGALKGVRELMTEHVEATVEHVDAETKPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S976</accession>
    <name>A0A3D8S976_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Kinetochore protein fta4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04398</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW82907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S976"/>
    <dbReference type="OrthoDB" id="21214at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031511">
        <property type="term" value="C:Mis6-Sim4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025207">
        <property type="entry name" value="Sim4_Fta4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42040">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT FTA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42040:SF1">
        <property type="entry name" value="INNER KINETOCHORE SUBUNIT FTA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13093">
        <property type="entry name" value="FTA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="140"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW82907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="240" mass="27467" checksum="958B340EF546F580" modified="2019-01-16" version="1">MTSTSAPTIIDLKTSFLRSQILTLSKPLKPSPAWEASYTSAREVEEEHLPRRRAVDESIQKVNASLKQHNRLAFPPQAQRHVAEQIDKLYWRAGEREREFGCEAWAERGVDYRRDDIIAQLPPIWSAEAESVAPEQAAQYTSLQARLVTLSEKRNAARQRLEEHRRLKELLSPFQDTTKLQENLVTRNGEVEKELEKMRTLMMRVERGVGTLEKAAAGDDMEIDFEEAEKKVRDLIVGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S9G1</accession>
    <name>A0A3D8S9G1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell wall protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04371</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW82880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S9G1"/>
    <dbReference type="OrthoDB" id="5243723at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017762674" description="Cell wall protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW82880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="22304" checksum="680DC7DE7A369B6F" modified="2019-01-16" version="1">MQFKNLFLTLLFTAVVVADQEDNGQSDDQGGNSTAVVTTASLCAKMAYLDQIVTESKNDTEVSIAQSGNPAKISAYQSIASAAATQLATMSTNTSLVSDCNVIDAAKATASQCKTMAKLQKEIDLASNSTKLQETTNGDATKIASIQAKASAAATSLATMTSNTTLVNTCNAISAKKASTSSSSAAASSTHASGADVLDVRTISTICFLAVGVVGVILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S9S0</accession>
    <name>A0A3D8S9S0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Checkpoint protein RAD24-like helical bundle domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_04588</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad17/RAD24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S9S0"/>
    <dbReference type="OrthoDB" id="10265971at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002611">
        <property type="entry name" value="Cell cycle checkpoint protein Rad17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004582">
        <property type="entry name" value="Checkpoint_prot_Rad17_Rad24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057927">
        <property type="entry name" value="RAD24-like_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03215">
        <property type="entry name" value="Rad17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25812">
        <property type="entry name" value="RAD24_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Checkpoint protein RAD24-like helical bundle" evidence="9">
        <location>
            <begin position="538"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="190"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="760"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="831"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="840"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF25812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW83097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="901" mass="97686" checksum="725E37F1F9DD6E45" modified="2019-01-16" version="1">MAPPAKRRKRNVVESSASGSDSEYEEKPATISKARLNDLISSSPPQTTSNAAVSSKGSAPKTTTTKSQPRAKTANHPHNAAPIYLPTGRSSKAGTKSASSSPEKRKSKTKLDASEKGKSGDIFTFFTKQAQRQQAVEPESKAAAKPSAVVNSTADELTDSISDGDDDNVGERKTESTSFIGRAVRKRAHGIGTLKNGDGDAPSSSQKFLRKPSTEEKKREEDLRPWAERFAPVNLDELAVHKKKVADVRAWLEAVMEGRMRQRLLLLKGAAGTGKTTTVQLLAKAMGCDILEWRNPVGSVATADGFQSMTAQFEEFMGRGGKFGQLDLFSNDGEQPTKIEANATTSRKRLILVEEFPNTFTRSSTALQSFRSTIIQYLAANTPPLSVMYNNNHKEESITPVVMIVSETLLTTTSASADSFTAHRLLGPEILQHPGVFSIEFNAIAPTLLAKALEVVVQKESRKSGRRKTPGPLVLKRLGEIGDIRSAIGSLEFLCLRGDTDGDWGSKVAFAKAKRSSKEGVPMTKMEEESLELITRREASLGIFHAVGKVVYNKREEVLSTRPSDQDVETLPDFMSIHARPRRSQVAVDELIDETGTDTQTFVAALHENYILSCDAPANSFEFSSLDHVNGCINALSDSDLLCPSWDGSFNSTGFGGGTGGRGSGGDILRQDELSFQIAVRGILFSLPYPVKRKAPAPAGLRTGRGGDAFKMFYPTGLKLWRMKEEIESTIDHWVTRMMKGEDTTFGTITSGAAAFAKPSTGTVESWKHRNSSAPKTSHKDSDANPLLSVGTSARKEMLLERLPYMVQIARAKKGPTSTFAIREMEKVTTFSGIGGPLEDPPDDGDDGAAGEEWATDKPVEGTSPKKKKGLVIRGRGTANTVPLLPREQKLVLSDDDIEDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S9U6</accession>
    <name>A0A3D8S9U6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_04521</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S9U6"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW83030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="69" mass="7759" checksum="31976902DE64824E" modified="2019-01-16" version="1">MIPAMQTKRHGVKAAYGPEAASVSAPLQRRRRVLSQIQAGYHFGLWRADCPMISLRWAALPWLEATLQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAF1</accession>
    <name>A0A3D8SAF1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_04796</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAF1"/>
    <dbReference type="OrthoDB" id="10257471at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000251">
        <property type="entry name" value="Ubiquitin ligase complex F-box protein GRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050648">
        <property type="entry name" value="F-box_LRR-repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382">
        <property type="entry name" value="MITOCHONDRIAL ATP SYNTHASE COUPLING FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13382:SF67">
        <property type="entry name" value="SCF E3 UBIQUITIN LIGASE COMPLEX F-BOX PROTEIN POF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="F-box" evidence="5">
        <location>
            <begin position="76"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="6">
        <location>
            <begin position="163"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="580"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="596"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="613"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW83305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="622" mass="68666" checksum="7F23CC76550D97BB" modified="2019-01-16" version="1">MRGSVPVMAPLDTDASYRATPEIEGDSQSSSSNSPARADFEESDFYAGNNDSQSSLGVPTFQDMAVSEESCVPPVHRLPAEVLIAIFSKLTSSHDLLNSMLVSKEWARNAVDLLWHRPACTSWEKHTSICYTLSKQESFFPYREFVKRLNLAALNNKVNDGSVEPLSVCTRVERLTLTMCEGLTDSGLISLITDSSHLLALDISGDTQITEASMFALADNCRKLQGLNISSCKKISNESMIAVARNCNYIKRLKLNECDQLDDAAITAFATNCPNILEIDLHQCRNIGNEPVTALLSQGRSLRELRLANCDLINDDAFLSLPSRQIYENLRILDLTSCARLTDRAIEKIIDVAPRLRNLVFAKCRNLTDVAVHAISRLGKNLHYLHLGHCGQITDAAVMHLVRSCNRIRYIDLGCCTHLTDDSVTQLATLPKLRRIGLVKCSNITDQSVYALASSSPHRGRLGDRGGHGPDLLHSGSSLERVHLSYCTNLTLKSIVVLLNSCQRLTHLSLTGVQAFLRDDLDAFCRDAPPEFTEHQRNVFCVFSGQGVTDLRHYLNSSDEISVSRARRQARQEAGVQALLDDEPMGGMHGTTILNTDDDPDGDGDEELEEGEISQNFDNTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SG85</accession>
    <name>A0A3D8SG85_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_03680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SG85"/>
    <dbReference type="OrthoDB" id="5342924at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="131"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="705"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW85355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="813" mass="89933" checksum="E67641EB77146128" modified="2019-01-16" version="1">MVNISAGLVDRCQHTANAHAPSRTMADRYGSNDVPLLEYQGGRGKSQEPSPTTTGGPRDGSFDQYGLPIKMEKKSKARTSILKNLKSRKHALVKSLLHLPSVVISLGILSLTFRRVFWEPPSSNTNVVLNALQFAAQFHGSLIIMSLSAMLLHLVHHDLGGKRGVPLGFLSSSFQLSSISYMFRKEFTSMNSRYIVIFLCASALAMLSGPSSAITMIPRLQFWSIDKLWLNKGHLDFHVYIAANETSLYPVTLTADDSPPQCLGSNASMLSQCPSYGARKWLLDTGLFGGWQDGQPSINTTIEESWIRYVVGTASMVNVGTQSVYLTSTLSNFLGRALFAYDDLLQNVRASNLGISGSATIQSEEESNLLARYDLSFRAAGKEIATRKPLVEIECAGYPSNSTSLSFLHNTMVWPPWQEEPIFSTEWSVSASDYANLSMDLNSTIVNSSWVDIAQFDGIKPSLAAIFTTPETVYPSGSHRYSNQSFYTCTIDARWMPTKVFTDASSGMAAVYDFFPDPNGPILAELDNGPVPDSMPSLYIAESWTKLIDVPWMDSVAFPVPTNRSILDTIGQKCLEQTSFLNVSILGTSFNDGLPRRVTTSPMNMLQCLQVSLSVFLADALARVQDAIPTYFVMEGHVQPQYPSSPSDIFLVQNLYDDYVVQSETVYGHVMNISQADLLDPSKFTEMYMPASRWGYGYGFQNSNLVIFGATILLLHVVLCAVYVAWTLGAGEYRSAGWDSIGDLVWMAMRSDLTRDDFSGADILNKKESLKKRWTDRFGVRDMEITAGDKHGNRSEMDGNTMVFRRVASRVDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SGN6</accession>
    <name>A0A3D8SGN6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_03757</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SGN6"/>
    <dbReference type="OrthoDB" id="4151048at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="54"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="160"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW85432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="318" mass="35424" checksum="8357E247ADA2B6D1" modified="2019-01-16" version="1">MSSYAGSENNDFPIKFSALCWDAASNTSEPNPSSAEREHRKKVMKSTRTRVSKACKRCRLRKIKCGGGRPCVRCSEADDVCEYSYQWKKESKEYSRGYIDQLLEQNDRYKRAMRVLYANRRLSIQPDTMVLPSTEGDDVPLVHDILDRLGLLDSRMDINEEEGETSDPCTHPHEAHGKTRAASASMPNLDHVSSPSDTVSDSMPATEPPNYDDYFGNLSQYTPPPDAPTLSNDDLDAIADVVFQIAPAAPQMDETSRAEQGYFGLPNVPQSQVMENQPFYDPALVVPLVGDLWGASNTNDFWIGTKDYSMGPAPFASF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHJ7</accession>
    <name>A0A3D8SHJ7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L35</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_04111</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHJ7"/>
    <dbReference type="OrthoDB" id="528635at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.310:FF:000002">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3450:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_uL29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045059">
        <property type="entry name" value="Ribosomal_uL29_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW85786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="127" mass="14635" checksum="D49D1682FA84E1FB" modified="2019-01-16" version="1">MSSGKVKTGQLWSKKKEDLQIQLNNLKTELGQLRVQKIAGGSSSKLTKIHDIRKSIAKVLTVINANQRAQLRIFYKGKKYLPLDLRAKQTRAIRRRLTKHESEKTLEKTKKRATHFPQRKFAIKAEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMB6</accession>
    <name>A0A3D8SMB6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_03018</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SMB6"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF28">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="335"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW87324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="516" mass="55259" checksum="F094DDC8596F14B1" modified="2019-01-16" version="1">MTVITDSSLEKVPTQKTGHDSEANGQAFDPDSLTVLGYTPELRRNRSLFTLLFQSLAIAAIPYGEGGPLISAIYGGGQLSIFVGWIVVLILDECVALSLSELASRYPTSAGPYYWSFQIAHKYKTVLSFITGWVWLIGNWTITLSVNFGFASLISATIAIYHPDFAANSWQLLLIFYAICLISFVVCAFGNKFLPMVDTICAAWTAISILIILIALSVKADVGRHSAAYTLGHYDTSFSGWGGFTFFIGLLPAAYTFSAIGMISSMAEEVDDPAVKVPKAISLCVPVGGFAGLFFIIPICALMPPLEDILGAPSAQALPYILHVVMGTPGGGLGLTFLVLGVTLFCSISITVAASRCTWAFARDEAIPGSRLFAKVSPSLGVPFWALVLTTVVQMLLGLINLGSSSAFTAFVSVGVMALQLAYAIPIGLSLFYRRTDVSKARWNCGPIIGPIVNVVALVWIAFEVVLFSMPTALPVTAITMNYSSVVLVGFMAIAAFWYLVYARKVYKGPPASDGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SND9</accession>
    <name>A0A3D8SND9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Serine/threonine-protein kinase ATG1</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Serine/threonine-protein kinase atg1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BP5796_03504</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 17">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 17">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SND9"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045033">
        <property type="term" value="P:peroxisome inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000011">
        <property type="term" value="P:vacuole inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14076">
        <property type="entry name" value="STKc_Kin4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000397">
        <property type="entry name" value="Serine/threonine-protein kinase KIN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034674">
        <property type="entry name" value="STK_Kin4/ppk1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="299"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="634"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="12"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="46"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="83"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="95"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="172"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="207"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="234"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="651"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="684"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="717"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="794"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="835"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="903"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="926"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="960"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1004"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="1017"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1042"/>
            <end position="1056"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDW87810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1176" mass="126813" checksum="DAFB814872548FE4" modified="2019-01-16" version="1">MSSAALQAAPHQPTSLGSQSPVAASSSGRPYTAGSSQSRDPYYNQNPPNASPSSARRASRRPSGNGASASNNLPHQQQQQYYSPTPTAGLGTSRSASAASQAASAAVVAATPSGYPAMSPGDHQRGVPPVVSPRTSSNRSGAERRESTRKTGYADGQSDRRRDNGQTNGTDAAVAAANAATRSRRKAQDSPGDALPHRSASNRESTRSQPAATTPTGPSREASEVLNRMIVSKPEVDLDRERERMAEAVPASPVADSHQSAMGMISTETPEDAPRGARSRHDHSASAGKREKNSRFGEYFLGNTLGEGEFGKVKMGWKQEGGVQVAIKLIRRDTVGSNPQRLAKIYREIAILREISHPNIVQLHEMVETEKHIGIILEYASGGELFDYILNHRYLKDNAARRLFAQLVSGVGYLHKKGIVHRDLKLENLLLDRNRNIIITDFGFANTFNPEDELGEEIESNLIDRDYVKRMDLNKILPSGSRRGDLMQTSCGSPCYAAPELVVSDSLYTGRKVDVWSCGVILYAMLAGYLPFDDDPANPEGDNINLLYKYIVSTPLTFPEYVTPHARDLLRRILVPDPRKRADLFEVARHSWLSEYSHVVGFITSSATTSADIGSATVGLEEEHGAPLLARSASVREASKSQKAPAAVGDLARKHGGVDAEESYPKPQKDNKRRTVQVEYVAPRSQTQRGETSVPPSGSKTRARAGSNGPVEVPAGQQASRRPSTSEKPLPQDPPGSRGAETQYAQGRRASGSQQRSQGMAPPARSGREAPRAVSDANYMQAPPSLARPATGNSMGSAASRSGSMALPSRGSYGQPAAPAVAGTNVHGRMAQPSRGKSYNSSTPASPDEISTDYGQPSITKVPSKFAKVSGHGQANQSSEHKSHKRSSTIGGIFSRTNSIFGKSDKGQEKAEKPEKSKKSYPPVSMNSTRQAATGGDTPSRQSIDSRRSTSFGFNKKRSGSITGSQTTLQEKPRRFSLLPASFSLKSIGIGKEYGNAGTPSEDGYDRPDSRNDYLDQPQSGRGESRNISGSTAGPQQSGDGGYDRNRDSPHQDRRGASTASPQQHHRYGSQAQTHNSHVLPPTNFRQGESTLNNESESSSNEQRRQYPAGFNEYDDGRSNNNRGGRGVLQKNNRRFADAYDEGNYGGTHDNAGSSGAARKVMDFFRRRGRARESDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SNT9</accession>
    <name>A0A3D8SNT9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gfo/Idh/MocA-like oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_03646</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SNT9"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004104">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000683">
        <property type="entry name" value="Gfo/Idh/MocA-like_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051450">
        <property type="entry name" value="Gfo/Idh/MocA_Oxidoreductases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377">
        <property type="entry name" value="BILIVERDIN REDUCTASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43377:SF12">
        <property type="entry name" value="BINDING ROSSMANN FOLD OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01408">
        <property type="entry name" value="GFO_IDH_MocA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02894">
        <property type="entry name" value="GFO_IDH_MocA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase N-terminal" evidence="2">
        <location>
            <begin position="31"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="Gfo/Idh/MocA-like oxidoreductase C-terminal" evidence="3">
        <location>
            <begin position="185"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW87952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="533" mass="59196" checksum="4C7E9CADCBB4D2D6" modified="2019-01-16" version="1">MAPHSDFDTIGQDIVRLPAPGRPPFSKSPPRLLIVGGGNRGKVYAAAIRESTNGICVGIVEPIAQVRRQFGRNNIWGKNEPSDGQEFEDWSDFIAWEEERRRKAALGENVPEPVDGIFICVQDQMHKDVILGLAPLGIHIMCEKPLATNLEDCVSIYRSLAPSQLFSIGHVLRYTPHNMLLRKLLLEDKVIGEIMSVNHTEPVGWWHFAHSYVRGNWRKESTSAPSLLAKSCHDMDILLWLLCSPPPGSSKPAHLPSTISSSGALNYFKKSRKPIAAGNATNCLSCDYEETCKFSAKKIYLGPETKPQVNNKIAVVLPEIEDCIASGGQEAGDKALLAKLRENYDDNTPAVEISKRGWYGRCVYESDNDVCDDQTVTLTWDEAPIAGEGETSLEAMTGRGGKIATLHMVALTQKICERYTNIYGTEGEIYADSSTIVVQNFNTRETKTYCPYVEEGGGHGDGDKGLARQFVLAIDRVKNHDETVEDAQNKYIGCSLEEVIRSHAMVFAAEEARLKKTVVDFPSWWERVVEQRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXC7</accession>
    <name>A0A3D8SXC7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02084</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW90919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SXC7"/>
    <dbReference type="OrthoDB" id="3564766at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW90919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="316" mass="35355" checksum="A27DD37BC8DC6CBC" modified="2019-01-16" version="1">MSENVLLIGNSSRRNLQTSYWSDLVQLDRSASMAKRNERSLEVRDDLDRERREMKSYSVKRKSPFSSPLQQPNVDDVSQPVVKATAQSSEVPAIGQQTDSRQTYLQENNELRDIKTSGPNSIMNCSIKDDHLPSNTSSDLEMLNICTSDQNVSDHEVGTNSMNHLSESMSTCTADQTDWDESSDGDSGCANESIRYQDDLASQAYRSPDRQILSAENILVDRLMTEFWIIFDQNWNCSIRHHATGTSTTSSSGSHAAASEQGSRISNNRKRARGKDPDDPNDRDERSGLVTTTLTGSRLSSLFVGRCPRFIRVEIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXD4</accession>
    <name>A0A3D8SXD4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Cytochrome P450-18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_02095</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 12">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW90930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SXD4"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000069">
        <property type="entry name" value="Cytochrome P450, putative (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 12" id="KW-0349">Heme</keyword>
    <keyword evidence="9 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="12">
        <location>
            <position position="438"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW90930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="495" mass="57034" checksum="A31DA13F1062DFC0" modified="2019-01-16" version="1">MALVALVVGAVLIYYIGVLVYRLYFSPIAKFPGPKLAAATLWYEFYYDVVQMGQYTFKIQQLHKEYGPIVRISPFELHIDDPEYYEVLYSRSSPRDKYEFFTQQFGNPLSGFGTVPHGLHRLRRQPLNEFFSKASISKLEPVLTTMTERLCSRIDQYKGTGEPLSMRHVYMCLTTDVITLYSMNRSWNHLDSHDFSPLWCKTIKATAEAGPLLKQFPWLFPIINSMPDWMLGALNPGMLLLLTFQRDIARQIQNIMDNPEEEGELPRTIFHALWKSDLPAEEKSLKRLWQEGQIVVGAGADTTASVLSVTTFHILDNPDKLQKLKEELETAFPDRYAPVTLAVAEKLPYLRVAPNETLQFHEWTIPPGVSFLTKPYSDLFETTYLPPIELQTPVGMTSVMMHHNEDIFPDSFSFIPERWVDKSLQKYLVPFTKGSRQCIGINLARAELCLVLATVFRRYDMELFETVRERDVDLAHEMFLPQPSQQSKGVRVMFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXH9</accession>
    <name>A0A3D8SXH9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-L-fucosidase</fullName>
            <ecNumber evidence="2">3.2.1.51</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_02134</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyl hydrolase 29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.51" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW90969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SXH9"/>
    <dbReference type="OrthoDB" id="6039950at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004560">
        <property type="term" value="F:alpha-L-fucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016139">
        <property type="term" value="P:glycoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000933">
        <property type="entry name" value="Glyco_hydro_29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057739">
        <property type="entry name" value="Glyco_hydro_29_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10030:SF37">
        <property type="entry name" value="ALPHA-L-FUCOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01120">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00812">
        <property type="entry name" value="Alpha_L_fucos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017833544" description="alpha-L-fucosidase" evidence="6">
        <location>
            <begin position="24"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 29 N-terminal" evidence="7">
        <location>
            <begin position="89"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW90969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="466" mass="50888" checksum="122C490479FA6D94" modified="2019-01-16" version="1">MKYSLRFLSVCAISIASAKAAAAATASNVTTIAPKYRISPLDGSTIALPTQDQLDFQDKEFGVLIHFEMGTYLDIDGCNNVPSLVPNLTLFDPALFNTDQWMDSITAVGAKYATLVAKHNCGFTTWPSQVEFETRDNTTISYNYTIAQTPVAGTDVVKSFASSAAEYGIGHGYYYSTVVNNFLNVQQSEIWFDGGYSTAQQTKFQNLLADLQPQAVVFNACDVTTGECLTNNSVRWVGTESGEAPLENWSTGITNDGGNATSPYFCPAVCDTTLQTGDRWFYGVDQPLRSIEELIEVYHRSVGRNCLLELDVSPDRSGLILAGHAARYKQLGDFIGSCYGAPVNAKHTANASSDGTYTLKFDYATSIDRIMLMEDQTNGQVIRSYEVWAKVIDDGVSDGTLDVPWTQVSNGTSIGHKKIDRFGAPVTVTEVLVNTTFVDTPVWRSVSVHLCDQLVATNTSSWEFTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXP9</accession>
    <name>A0A3D8SXP9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">OPT family small oligopeptide transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_02250</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oligopeptide OPT transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SXP9"/>
    <dbReference type="OrthoDB" id="9986677at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035673">
        <property type="term" value="F:oligopeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004648">
        <property type="entry name" value="Oligpept_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004813">
        <property type="entry name" value="OPT"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00727">
        <property type="entry name" value="ISP4_OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00728">
        <property type="entry name" value="OPT_sfam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22601">
        <property type="entry name" value="ISP4 LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03169">
        <property type="entry name" value="OPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0571">Peptide transport</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="292"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="435"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="494"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="521"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="548"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="602"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="676"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="707"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="753"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="21"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW91085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="813" mass="90657" checksum="45C2B3E3F0CBEE1D" modified="2019-01-16" version="1">MRFRAPWAQRDEPPTGETIEAVSSHSSDGNSAPTTDEKHSKAPEITAQEAIDVPKFEKNHQWDPNLPQAEIDAIHNAAAGDVEAVHAVEALFTEDSPYPEVRAAVRNTDGEEVANTVRAWVLGMLSVTVASGLNMFLSMRSPAISFPSIVVQLLVYPIALFWARVMPMRVFNTFGVKWTLNTGPFTIKEHVVVTLMANVSIGYAYSTDALLALAGKPFYNIAMGWGFQLLFTLSSQLIGIALAGMFRRFLIWPSAMVWPGQFTNTTLFYALHDKSSSDPAKTNGWIISRYRYFLYVMLGMFFYYWIPGVLWQGLSIFAFVTWAKPNNVVINQLFGGFTGLSLIPITFDWTYVSAYLGDPLLAPVHSLVNTLIGLVFFVIITIIGLSFTGTFYSDYLPINTSSTFDNTQGSYNVSRILTPDFSFDLAKYKAYSPMFLAPSFALNYGLSFAALTAAIVHTGLFNGKEIWYRYKASRKQEPDIHMKLMSKYAEAPDWWYGVLFVISIALGLATCLGYNSQLPWWAFFVSNILALIFIIPTCMLLATTNIGLALNVLSPFLAGFMIPGKPIGVMMFKVYSTITLGQAQTYSSDLKLAHYMKVPPKTVFFCQIVATIWASFVQIAVMNWTLGNIKDVCTTTQSANFTCPNGKTFFSSSIVWGVIGPTRMFGPGSIYAHMQWYWLLGALLPVLFYGLMRAFPRSPARYLNAPIMLGAMGWLPPATPLSFFTWVIFGLIFNMSIRKRWPGWWGTYNYITAAGLDSGLVLSTIVIFFAITYPAVTLPQWWGNVGVFNTLDAQYAAIRKILPDGQTFGPKTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SY43</accession>
    <name>A0A3D8SY43_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">cAMP-dependent protein kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_02359</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8 9">Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SY43"/>
    <dbReference type="OrthoDB" id="417078at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000039">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000006">
        <property type="entry name" value="cAMP-dependent protein kinase type I-alpha regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012198">
        <property type="entry name" value="cAMP_dep_PK_reg_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000548">
        <property type="entry name" value="PK_regulatory"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 10" id="KW-0114">cAMP</keyword>
    <keyword evidence="4 9 10" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="12">
        <location>
            <begin position="142"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="12">
        <location>
            <begin position="273"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000548-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW91194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="397" mass="42867" checksum="2A42BD8209BC51D5" modified="2019-01-16" version="1">MAMAGNTFPGRAGSNPNPFGGPLGGGNEMASSGVINRVVEEDENDTITSPTTPSFGFSKGNNSTFGAPFGNDGAGEGPPSSFRPGVGAEGFPAQYSMGRRTSVSAESLNPTASSNDNWTVPFHEKSQEQIARLKKAISGNFLFSHLDDEQSAQVLGALVEKKYPAKLKIISQGDEGDYFYVVEKGSFDVHVNPNGSLQSGAEGLGNKVATIEPGGSFGELALMYNAPRAATVISVDSESTLWLLDRVTFRRILMESTFQRRRLYESFLEEVPLLSTLDPYERSKIADALEAQKFPPGTTIIKEGDAGDAFYLLESGEAEAFKSGVDNPVKFYKKGDYFGELALLNDAPRAASIVSKTEVKVATLRKDGFQRLLGPVESIMRRTKYEQGVEEIDPLQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYM3</accession>
    <name>A0A3D8SYM3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02588</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYM3"/>
    <dbReference type="OrthoDB" id="3550599at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="645" mass="71704" checksum="22F283470100CC89" modified="2019-01-16" version="1">MANSPNWRCYRCTRRPDPAPPPGPFVFKGAKVAIKSAPISAASLKGPSNNPSTNMFSGRQCERIGCDKPVMQTPGLNAWKTDSNASRLCKQHQMEERHRLASRHGQEGDQIHSSAGPAQRSIDKKKLYRSSFKNRHQPDSFSDSPIGIAAELSSPITPATEQIFRIIPEQGSVASTTNPSTADATTGVGLPVTGTNLGDQLPMVAKDIVVSLDKEPVSSLSSDNTNKQDVEMPDVTEPGETPSDATNATRKSLADGIQIRETNDISHHASPRVRGDNEVRKQRCLDSLQADWGENFHTQLPAWPEPPGKTFLEHLLKLCKVEGVSFEDFKVGITAIYHQRVAGKTNLQRVEQFIKLSDVKLFASQYADQKQHGNKSIGLGNDNKEYRLGSFESHDEIMLPLRRTRAPTTTASITATVCSATDQATNEEWPQIEETMGNPQNTELPVFQQTSPTPTQFVNLNQGSHSAHKIPSGDDKSQEDAQCEAIIARVHPQSIEARRNTDRNSFQESKLDSFLRAPQILTGKFDQTAWGKIQLPIDWPPTKALDPMFLENKRKEIAARGNRKSAERYGKHLTPEVVKFRKEMGWEKHQNRPARPASEEVARHMRELFGLPNINNMTPYLYNGKLHMGDKTEDGSFPTKLYPVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZH7</accession>
    <name>A0A3D8SZH7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Cytochrome P450-21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_02814</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 4">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZH7"/>
    <dbReference type="OrthoDB" id="2789670at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11061">
        <property type="entry name" value="CYP67-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF172">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 4 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="4">
        <location>
            <position position="439"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW91649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="493" mass="56052" checksum="2393B51C87EE11F4" modified="2019-01-16" version="1">MLFQGLLALVIMVVFVQPIITYVLDPKHLRKFPSPQYAGLSSIWRIIQNLKKRHYLAIDDVHRRLGTHVRIAPNHISISNPQAVQDIYGHGANFMKDAWYDGGAGEYRHMADTRIKAEHQAKRKKLAHLFAQKTIANLEPVVCGCTGVLVNQIDNHIASNKPINMRRYLNYYTIDLFAELLYGYSLECLERGDDIIDAETKNGKVYKVAFIKSLHEATIKNTVLGMEAPLLPLTKKLFSWHPYMKSGADYDNIVHHNTVKRMRATNNTEDIFSKLLQNSKGEDLNLPFGEVFAECNVMMNAGTDTTTAALTNSIYLIYKHPDVLQKLRKELDGATGEEEVPSYDKLANLPYLRACIEEALRVRPASSMGLPRVVPKGGRWIAGQFIDENVTVSVPTYTLLRNADAFDDAASYIPERWMEGDKDRMNRAHFPFSTGPRACIGRNIAYFEQVLVIGTLVRLFDFDFQSEDFQLETLERFNSNPGEMFLTARRRCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZK0</accession>
    <name>A0A3D8SZK0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_02907</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZK0"/>
    <dbReference type="OrthoDB" id="420380at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF246">
        <property type="entry name" value="TRANSMEMBRANE PROLYL 4-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017700800" description="Fe2OG dioxygenase domain-containing protein" evidence="6">
        <location>
            <begin position="18"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="7">
        <location>
            <begin position="130"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW91742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="266" mass="29367" checksum="6F3E697667EE2BCC" modified="2019-01-16" version="1">MTALWSVLFVAAVAVLGKNYGIYSEWFPAGASTEVATTADTGCDEYHGYQIEFLSSDPLMIRIPNFISPAESAFFTGILAQNFTYRLYVNEEDVKNKIAPRLAVLDQHDPYVTCILNRAHHFLGSMASPDFELLSVARYGVSHQVSLHTDASPEPLEDSVTKRQFNRRTSFFVYVHSSDDLEGGETYFPRIPPPSNVDLSTHPGIVAVNNASGQPGLAVKPVSRSAVFWLGMKPDGTVDRSTIHKGLPVTKGEKIGMNIWAKHYLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0A5</accession>
    <name>A0A3D8T0A5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_01397</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0A5"/>
    <dbReference type="OrthoDB" id="4898680at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="286"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="599"/>
            <end position="618"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW92003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="667" mass="74626" checksum="E35D8C9EBB0659FD" modified="2019-01-16" version="1">MSKVTALKKARAEAYLSPTPTSVLSTPPVEVARRNSIGDSGPFKKSAGFFGPTNFSAVFLENHEDLGGDIPISSQDSDPSGASHEILQSQTFLMIAGTDVCGSPRIALGAKVIQHLPDERSFSFLLCRYSEKVNECVLHKQSVLQCAASIWTTFGQYLEEPRRSEDFERMSAVLCKNGETGLEEIDDYEEWVASFTGMNMRWETLGAVFTTLGHAILSLPERDPFFCSQRGLRSNRKAWASELKDCVQACVTLSNYGDLINVHMVALLAKNHLFQTIISGDASLVVWRQLGDLASASTALGLHRQVDTAQSTSVVSEWKKLLFLVVFNMDKCASLLTGRPPTLSSRYTHISMPLDLSYQVRIAGGETLAREIARLDENGWNVDGKLYPATTCRAHGRLSLVLDEILELTLGDTEAVTCERINHLLQKLIKTYTSMPRFLQWSPEDDSLPNDQLLWRKIGLRLKCLESKLLLERLLYKIGGSDGSSMIECAKEMLELTVLIWVQRDRYIEHHLDYDYFLMCFGVPASGVLCVELLRRIKQPKETAHLPPIARSEIVQKLSLLIGFLEWVRPAAGNYQLCSRMRQIIKRILDQILNPTPVALPQPETESQTAVEPFDDTPLASTPFSYDDGLDNLDWLNSVDWSRGPWIDLAGPDNYSMDPRSIYLPQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T167</accession>
    <name>A0A3D8T167_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_01142</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T167"/>
    <dbReference type="OrthoDB" id="4869816at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="272" mass="31001" checksum="9774C1BBFFC79E1E" modified="2019-01-16" version="1">MQAGLRDVLGEDGIAEMAEYNFQQQQQAEREKQKDAAAGGTEDEAPPVIIPNWLKQWQKRYEGQEWGFVAIKSACYDDEERWEKFKQVFQEIIQIPFDRVEATIAAAAKAREILQIRWIEDPELDGASIQVPQERYESLQPTLPAGQSHPVFLSASSDAIESVLSASPVPSIDSKYWRPPAPYILAVAASSDPGLDEGHKEREWFRDLFKVAVEVLVEEFWFVVDSDLMPLRRVMRGVKGVNEDEEGDAGLEEMWWSTSPSPGRMRKRTRME</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T170</accession>
    <name>A0A3D8T170_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Wbp11/ELF5/Saf1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_01716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T170"/>
    <dbReference type="OrthoDB" id="5597581at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019007">
        <property type="entry name" value="Wbp11/ELF5/Saf1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09429">
        <property type="entry name" value="Wbp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Wbp11/ELF5/Saf1 N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW92322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="285" mass="31011" checksum="15E273DE5C903579" modified="2019-01-16" version="1">MPKERSINPAQAQRKAEKAKAIKKGKAEAQARKDEKLARRNPDRLQKQLDDLKAIESSGGKLTSHEKSVLEGLEKEIKAVRKARETLGDAAPKLGRGGFGGDRGDRGGRGGGVLGKRRRGDEGESSESDVPEDVRSIPMPRDTPPPIPKEALDKWYQRRRERNGHTVAGKGTNANNTPLGQDRIPDRPQGSASPAPVTETKTVYEAKPIIRDLRKEAVSAFVPAAVRMKMDKAKGSGGLVEPEEADALERAGYMARGESSERRDSGTSEQANKTVMMEEVDDEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T175</accession>
    <name>A0A3D8T175_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_01721</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GAMAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T175"/>
    <dbReference type="OrthoDB" id="9985637at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004942">
        <property type="entry name" value="Roadblock/LAMTOR2_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10779">
        <property type="entry name" value="DYNEIN LIGHT CHAIN ROADBLOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00960">
        <property type="entry name" value="Robl_LC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Roadblock/LAMTOR2" evidence="3">
        <location>
            <begin position="15"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="42"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW92327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="131" mass="14017" checksum="2451A7C6C2C805F7" modified="2019-01-16" version="1">MQVNPLKSDGTTTVLEEHLQRLGSKSGVVATVVVDTPTGAIIKSQGELPPSHGSRTRIGADEETASGTQSEGIEELASMVWNFVKTAGGLVQGLDSEDELKLLRLRTKKYELVIVPDPKFLLIVVHNTPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T243</accession>
    <name>A0A3D8T243_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_01998</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T243"/>
    <dbReference type="OrthoDB" id="5595695at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01299">
        <property type="entry name" value="Met_dep_hydrolase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057744">
        <property type="entry name" value="OTAase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="71"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW92604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="443" mass="48594" checksum="9B968241B937BDC9" modified="2019-01-16" version="1">MRKEIMPQRQSSELTVHTSLMFDSKQKKFISDTSMVIDRRTGLISKVFKRDEQLAQQDVSSPNTVDLRGWTVLPGLVDAHTHIFLHEYSETPSLYQMRDESLVERVVRATNHAKAALKAGYTTYRDLGTEGLRDADVHFRDTINRGIIPGPRMFVATECIASSGGYEIRQENGMPGGTTVPRISDSADGVDGVRAAVRRRLGAGADIIKFYADYRKRVLRFPPSTWPGSRDVMFPPSGDPLTGDRNPNLLQFTQEEMNEIVAEAKRGQAPVAAHAQGPEAVIMAAKAGVTSIEHGYMPSKDALQAMKENSTIFVPTLSVFDSELRRGDEDLERIFRVILDHTKAAYDHGVKLACGGDTGAFPHGDNAREIELMVDAGIPILDVLQAATLHGWESCGGDLCGRRFGVLAEGWAADLVALDGNPAEDLGALRRVAFVMKDGQICN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T2Q3</accession>
    <name>A0A3D8T2Q3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_01672</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T2Q3"/>
    <dbReference type="OrthoDB" id="10597411at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017732826" evidence="3">
        <location>
            <begin position="24"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW92278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="217" mass="22606" checksum="562AFC7ECE6AAA4C" modified="2019-01-16" version="1">MSSNSRIFGLVAVLLIGVQRCSGTSEFQPTVTVPTVTKPATATSLASGQLTYYYYTITWSYTYWYYTWTISQDFATTELTSTTSTEYTTISVYESNSAAASSAFSLISTDIVPPTPAQLTNPIPVGTSPAAPEATASRPAETPSSSNSSSASTSTTRPATTTVSPSTSTSTIVASGSSAATSLGHSGSIGLPQFLSSWLLSASIGLIIFPGLLMVWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T6T1</accession>
    <name>A0A3D8T6T1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Apoptosis-inducing TAF9-like domain 1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_00012</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TAF9 family. CENP-S/MHF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T6T1"/>
    <dbReference type="OrthoDB" id="1872155at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071821">
        <property type="term" value="C:FANCM-MHF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22919">
        <property type="entry name" value="HFD_CENP-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029003">
        <property type="entry name" value="CENP-S/Mhf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22980:SF0">
        <property type="entry name" value="CENTROMERE PROTEIN S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22980">
        <property type="entry name" value="CORTISTATIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15630">
        <property type="entry name" value="CENP-S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW94249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="108" mass="12187" checksum="79550C50E17C985D" modified="2019-01-16" version="1">MDDELQERLKAALWYSIGKIVDEETMRLNTNATPQFIGALSEMVWAQIENVAIDLESFSRHAGRMTVNTDDVLLVTRRNDALHGIIEDFINKEKAKSAKTPGKARAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T703</accession>
    <name>A0A3D8T703_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Calcium-channel protein CCH1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BP5796_00100</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Voltage-gated, high-affinity calcium channel that functions together with MID1 to mediate calcium entry into cells. Required during conditions of environmental stress.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="19">Membrane</location>
            <topology evidence="19">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="16 19">Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="416585at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005891">
        <property type="term" value="C:voltage-gated calcium channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008331">
        <property type="term" value="F:high voltage-gated calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098703">
        <property type="term" value="P:calcium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000093">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.70:FF:000118">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000063">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000079">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.350:FF:000098">
        <property type="entry name" value="Calcium channel subunit Cch1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005821">
        <property type="entry name" value="Ion_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050599">
        <property type="entry name" value="VDCC_alpha-1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002077">
        <property type="entry name" value="VDCCAlpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45628:SF7">
        <property type="entry name" value="VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00520">
        <property type="entry name" value="Ion_trans"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00167">
        <property type="entry name" value="CACHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 18 19" id="KW-0106">Calcium</keyword>
    <keyword evidence="6 19" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="5 19" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="14" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 21" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="9 19" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="409"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="518"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="543"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="577"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="717"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="789"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="820"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="850"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="873"/>
            <end position="899"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="911"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="943"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="984"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1211"/>
            <end position="1238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1250"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1287"/>
            <end position="1307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1344"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1466"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1547"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1579"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1609"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1672"/>
            <end position="1694"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="21">
        <location>
            <begin position="1765"/>
            <end position="1784"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="22">
        <location>
            <begin position="1803"/>
            <end position="1838"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="146"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1083"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="2052"/>
            <end position="2094"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="146"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="196"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="20">
        <location>
            <begin position="206"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="20">
        <location>
            <begin position="1092"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="2052"/>
            <end position="2068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="20">
        <location>
            <begin position="2076"/>
            <end position="2085"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="1438"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00057587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00061395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00067459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR602077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="RDW94337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="2127" mass="238109" checksum="3D75D4D8495377F5" modified="2019-01-16" version="1">MPPANSQDAGQPSTPPQSIPLRDLQHPPDSTDLADGERWNMRGRGLLSGSRPTSGHNDGPRYERLGDTSPSPGTRGNPRAVVATTSHQQPSVADEEMPLSPGDNPADFQSALGFAGLNVPDISFSQAPPTRKLSYDSGEFDRVSPYSSPYHSNFEDSQSYFPGDSDTLPLTNHEHLQPISGARATTPDGQNHDRISFQSVQFTPESRTRGTRLGDDLHNAEAGLSPSAGRNRAYSLGTSLSPDGRSRSRSPSTVGALSRAGSVMRAMSQRVVNLSGDAELLEQHARQQANAEIETAQPRASINPMNGDETYRNEGWPVPFEKAPPNFSTSEPPSASWQQEPQNPLRGKTLGIFAPDNKLRRKLCDILVYPVTEPFILILIVLQTVLLAVEAAPNVYTDPRPKSWGHSPIDWTILALFVVFTLEILARMVVSGFIFNPPEYSTIDRERGLKGALVDKYRAVFAPERKSSLRVPRTTLYEAPTIIRSFTTMQGPEVLTVEQAQRQQLARRAFLRHSFNRLDFVAVVSFWAAYLIGLFGVESENHLYVFRMLSCLRILRLLALTNGTAIILRSLKKATPLLLNVSFLIGFFWLLFAIVGVQSFKSSLSRQCVWLDPLDTTNMTAAYVNSLQFCGGYLNNDTGAKLPWVQGDLANLKPGADNHKGFLCPRGSICLEVGPEYRPYNGTVNFDNILQSLELVFVIMSSNTYSDLMYYTTNSDYLAAALFFAAGIVIMMLWLMNLLIAVITSSFQVIREEGKASAFAANKDLPVPEDTTDPRRVSGLKRLFDKTSWIWVIIIAFDLLCQALRSASMTRAREELINNVETVVTFVLLFEIIVRFAVDWRGFHRSWINWFDLALAIITTIIQLPQIHSSGNAYAWLTVFQILRIYRVVIAVSITRSLIMLVLGNAKGIANLVLFVFLMTFLMSIFAVQLFRGELPQADDGGNTIEVTFFTIYNAFLGMYQVLSSENWTTIMYNITSFDNARNTGWIGAVFFIGWFIFGNFILVNMFIAVIQENFDVSEDEKRMQQVKAFLNRKEAVQGSSNLSLSSIFRLGRTGGKKDPLDYGPATMEMLLKDAVVKDFLDDEGPESIPHGPTPPSPPVEPSVEERGFISSMKRKFITRIWHREPNPFYSYGMAFSRTDDHTDARTMAKDAVSATTQRKRLQREFLARHPNYNNSLFLFKPSNPLRRLCQKIVGPGRGSERFDGVEPNRVVWYIFSAFVYAAIVAMVLLACVTTPLYQKEYFQTHTFAVANWFVWADTAFAILFTVEALIKVIADGFFWTPNAYFRSLWGFIDGIVLVTLWINVVTSFRNDGAISRAVGAFKALRALRLLNVSDSAKETFNSVILVGGWKVLSAAFVSLSLLIPFAIYGVNLFSGKMQLCNDSSNITNLTACFGEYSSTPFSSDWPLLAPRAVSNPYYDFDNFGGALFILFQIVSQEGWVDVMWSAQSITGPGLQPQDFASQGNAIFFVIFNLLATVFVLTLFISVFMRNYTEQTGVAYLTADQRSWLELRKLLRQVSPSKRPSSEHGNKFKAWCYKRATRKHGTWHRATTIILVLHLIILLLEYDSEPTWLVNTRDYVFLAFTVFYIANVFVRINGLSWARFRRSSWDVFSIFAVAGTFATTILLLTNFTSQTYIQLHKLFLVSIVLLLIPRNDALDQLFKTAAASLSNIGNLLATWFALYLVFAIAMTQTFGLTRFGSNEDGNVNFRTVPKALILLFRMSTGEGWNTVMEDFATIAPPLCTPSNTFFDSDCGSAPWARALFISWNILSMYLFTNLFVSLIYESFSYVYQHSSGLGKISREEIRRFKQAWATHDPDGTGYISKEVFPRLLGELSGVFEMRIYSHENSVRSILEDVQSRPSSISAPSIASTSAATGIDLKKLNARLAKIKPLAVQRARARYNLFFQEVMVSADPDHGISFTSVLMILAHYNIISDNKSLRLEEFLRRRARLQRVEEEVRRRIVVGFFDTMYWSRKFRKHVEKKKSGRMTTIPQLGPEVFIDEDEGVSNNRKQSSAMLSPVEAENSRNSFIAYGLDGPKGRARRGTEVSINVGQLSPQLSPQRATASGFNLEASGDTGSAANSAHSSRRGSAVSAENVLEVLDNSAWGESIRRSFTMRRPSKADHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T761</accession>
    <name>A0A3D8T761_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_00133</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T761"/>
    <dbReference type="OrthoDB" id="10313099at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="45"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW94370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="400" mass="44661" checksum="E3EE36C423002908" modified="2019-01-16" version="1">MTSTPYVGSREEWYRTPSPMKHVPHPLQEQFERMEQRLTHLASLNSKHREQLRTLDEDMSKLRERSVGLSREVAGYATTISTPSSPHSPTKPVTITYPALLPATPPSAPPSTQHSSMKTITSPEVLPFTLQPPPPKEVFRSLVQELPSTPTKKGRSTTSSIAAGFWKGFWTPEKADPSSPSSSPDLLTPGKTHFRVAGQETVSPPVPQGFMFRSSHFSALSPPKKTLRIQTDLLEKDTTVPLKITFSPQRPDFPMRPIDVTLPAPTEIKSAPMRLMSAPKPKSYREPGHPPLEAAFTVDIQPDQVKNLTRLPIRASQHKRDMSEVKSRSPTNPELWEPFPDIRREKFHSELDDVAWQNSVVGKAEMDMRAGSLSPLQIPDKAESGDVGLRNLLDARTIWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T787</accession>
    <name>A0A3D8T787_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Stress response protein NST1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_00162</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 8">May act as a negative regulator of salt tolerance.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the NST1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T787"/>
    <dbReference type="OrthoDB" id="21629at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051195">
        <property type="entry name" value="Fungal_stress_NST1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025279">
        <property type="entry name" value="NST1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31780:SF10">
        <property type="entry name" value="LD36051P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31780">
        <property type="entry name" value="STRESS RESPONSE PROTEIN NST1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13945">
        <property type="entry name" value="NST1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="311"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="447"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="546"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="916"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1173"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="195"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="359"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="472"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="546"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="622"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="716"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="739"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="789"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="916"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="929"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="977"/>
            <end position="987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU049441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW94399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1205" mass="132718" checksum="4DDEF9C1762DD067" modified="2019-01-16" version="1">MPANQRQQTAQIPASPTAKATAKYTNKDGSKFIKVPKNFPVSDSSETSPAMAQTTTKANGQIQIPSPEPNGSAPAGNRKKQKRRQKQAAKLAAQAGDHHLSTAVDMQREVSRLEAQLRQSGLDDHRDLGKNGQFDPADGDPYDSDDDEGDGYSGSYGHDASPPNGYAMPPQNTSGKKSKKKKKSKSGQHAAEQNHVGTNSMTHNHLSLPHGSLPPLPTTGSIVRGPGISKEKIWNTSSQEERERIKEFWLSLGEEERKSLVKVEKDAVLKKMKEQQKHSCSCTVCGRKRTAIEEELEVLYDAYYEELEQYANNQGGDGPPMMPPPRRFGAMSGLQPPHRLPPVFSGQQPSRGRIIEHVGDDEDDEGDEEYSEDDADEDEYSEEEPEEPPRSHATDFFNFGNSLTVQGGILTVADDLLKNDGKKFIEMMEQLAERRMAREEESKMDHYANMNYGHPPNGSMPHVHGHNHPPPADEDDYDDEEEEEDDYDSQDEEYDEEEMDTMTEEQRMEEGRRMFQIFAARMFEQRVLTAYKEKVAKERQQKLLEELEEETRADSQKKAKKAKDAQKKKEKLAQKKQAQAEEKAKREAEKAAEEAALRAAEEKKAEEQRQKAEEKRRKKEAQKKAEEEERLKKEAEKQRRLQEQRERQAELERRQREAKEREKREREETRQKEKEAKEAKEREARERREKVEREKKEKEAKELQLKDQQKRDEQAVQHTPSTAAAQATKRAHIPVPIPTTLQSHSSATASPHLPITTPAVPKAPTPIKTRPTSQQDISVAVPRTPQLPGKSQNGSPATSTPLQGSPGPVGPPGKGPIHHPFLHQPQASSPIHAALKGPPGMPRSPFNGVQPMGMNGFPPGVPIMAPGFGGQMQQPMFPYQQPFGPPNGIPFSPSMQMPGGRGFPMPYGPPGFLPNGGMGGLGQGFGAQKDTTPPQTHSRQQSASFDKSFDPATPPAQPIARPAPIGRPPSVVHGHSHHQENKHSMHSDIDELSNHLGSSALLDDSDEPITSAAGARRSSAAPMTRGFGPSAPFGMDSGFSSPLSSYGGWGAPPNPFGPSSLPGSNYLGGWGAPPNASFGSMNGAPAMRPSQPRSVAVRLMICRACKNLNGTTSDGFLDISTIKEQVDQLNPLHEQPVTEKELLDICDTEGNANNGGGSFEIRNERFVRYESDVPSHRSMGAPGEIGSPIVGGGERISRFAGPPGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7H2</accession>
    <name>A0A3D8T7H2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Auxin efflux carrier</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_00295</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7H2"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004776">
        <property type="entry name" value="Mem_transp_PIN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31794">
        <property type="entry name" value="AUXIN EFFLUX TRANSPORTER FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31794:SF4">
        <property type="entry name" value="AUXIN EFFLUX TRANSPORTER FAMILY PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03547">
        <property type="entry name" value="Mem_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="324"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="394"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="142"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="149"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW94532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="426" mass="45696" checksum="E4B09F94A9814820" modified="2019-01-16" version="1">MADGILESFLGALQASLAVLLTISYGVIASRYGLLKESSSKDISKTCVRLFLPALLITNVGSELKAGTAMRYVPVLMCQVPADKSSLPLVLVQSLDSSGILKQLTMGDDSSSSAVSRAKSYFLVASVVGNCLTFAVGPKLLDDEDSPAEGEHEDNKQNEDGGNNIQAARDEEEATPRNSEGRTAEEEEDYVSESTTLLPDAVARREAHAEEEVLKEAKRLCMKFPGSVQKAFGFVGSLMNAPLIGAIIGAFLGLIPALHKAFFDEPADGGVFKAWLTTSIKNIGELFPALQLVVVGAKLSNSLLKMKRGEASGNVRWIPSLTIFFIRFLLWPVLQNACTRVSIAIIYLVVAKTQWLDDDPILWFVLMLMPTGPPATKLTALADVSGASDEEKMSIAKFITISYAISPVICFAVVASLKASLAAKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T853</accession>
    <name>A0A3D8T853_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_00468</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T853"/>
    <dbReference type="OrthoDB" id="3448456at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="5"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW94705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="241" mass="28407" checksum="03216BD3598E28E3" modified="2019-01-16" version="1">MARSFTLFPRLPPELRRLVWQFCLPAPRTIFMKNTRVASRSLSCRRRKVICVPSTRCPDIILLLLHLCVESRAATFAEYEVLFACRSNRDQYYRQHFFAPARDSIFIEDVRFPARSRMPQHIWPWHQNIKPSAAIYHVRKLAIGCNAWWNLWKRDDTRRYLLGEGGLLMFKKLEELHIVFRIVTGHDWDAGWRSDDLNWPLPDVNIQPEPIKKVFETMGKKHAEWKVPGLKLVAWGKLAAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8L2</accession>
    <name>A0A3D8T8L2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Histidinol dehydrogenase</fullName>
            <shortName evidence="6">HDH</shortName>
            <ecNumber evidence="6">1.1.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_00653</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-histidinol + 2 NAD(+) + H2O = L-histidine + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:20641"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:57699"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 6">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6 11">Belongs to the histidinol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.23" evidence="6"/>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8L2"/>
    <dbReference type="OrthoDB" id="1703565at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00014"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004399">
        <property type="term" value="F:histidinol dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06572">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000001">
        <property type="entry name" value="Histidinol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1980:FF:000026">
        <property type="entry name" value="Histidinol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1980">
        <property type="entry name" value="Nitrogenase molybdenum iron protein domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001692">
        <property type="entry name" value="Histidinol_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022695">
        <property type="entry name" value="Histidinol_DH_monofunct"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012131">
        <property type="entry name" value="Hstdl_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00069">
        <property type="entry name" value="hisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256:SF14">
        <property type="entry name" value="HISTIDINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21256">
        <property type="entry name" value="HISTIDINOL DEHYDROGENASE HDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00815">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000099">
        <property type="entry name" value="Histidinol_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00083">
        <property type="entry name" value="HOLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00611">
        <property type="entry name" value="HISOL_DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0520">NAD</keyword>
    <keyword evidence="5 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0862">Zinc</keyword>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="321"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR000099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000099-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW94890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="442" mass="47507" checksum="4584F58DD650DEC4" modified="2019-01-16" version="1">MSQYLKKATGSAAGNLAAQESVTAIVKGVISDIRRNGDSAVRQYSEKFDKWSPASFKLSQEQIAEIIASVPEQTIKDIKEVQENVRAFAEAQRKSLTDFEIEIRPGVHLGQKNLPINAVGAYIPGGRYPLLASAHMTIVTAKVAGVPNVIACTPPIAGQIPQATVAAMYYAGADEIFILGGVQAVAAMAVGTETIRKVDFIAGPGNAFVADAKRQLFGEVGIDLFAGPTEILIVADEHADPFTIATDLISQAEHGPDTPAVLITTSESVGKQSIELVNRLLEFSALSTAALAKTSWDAFGEVVVVPSLAEAWKLADEYASEHVEIFTQDPREALRKMTNYGALFLGEKTCVSYGDKVIGTNHVLPTRKAARYTGGLWVGKYLRTVTYQEVTNDIASGELGRLCGRAARAENFEGHARSGDLRASKYLADKHAWIDGKEEARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T934</accession>
    <name>A0A3D8T934_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_00855</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T934"/>
    <dbReference type="OrthoDB" id="5374328at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050936">
        <property type="entry name" value="AP-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018287">
        <property type="entry name" value="Hap4_TF_heteromerisation"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621:SF7">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40621">
        <property type="entry name" value="TRANSCRIPTION FACTOR KAPC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10297">
        <property type="entry name" value="Hap4_Hap_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BZIP" evidence="4">
        <location>
            <begin position="74"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="168"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="253"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="85"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="191"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW95092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="519" mass="55498" checksum="1E513B96F19507E5" modified="2019-01-16" version="1">MASPPTPCSSAGSPPSLAPAPPVLAIKTMNNPNNASLASAAGLPTPTIVTRKEWIVPPRPKPGRKPATDTPPTKRKAQNRAAQRAFRERRAARVGELEEQLEETKEEQQRREADLRDKIQRLEADVLRFSGEIQSWRIRCDTLDRIAEYERREKDAALTELSYLRNGARTTGTDAVPLPPRRNRHQEPKESPSLPSALTPTPVEPAGCGNCTPSQCQCLEEALKVSTSGCGKCHAGSNCECLEATITGTALNISSSNDHKRPLSPSAEDSSEKRHRSGSSTPLEIDFTAQFSSKPITNHVIPTQEIADPIVSRPTESCGFCADGGFCVCAENAAHAPNDRENRLAPLLNDMTPPPSDTDVDGTQASIKLPSLQPNQMHRPMGAPAASNSCVNGPGTCAQCQSDPKAGLFCRSLAAMRESSNSAPPEGCCGGKGAGGGCCKSAPAPAPVQQQPPPSLSVADTYKTLSTHRNFEQASDELNTWLGRLHATPPHHVGRAPMEVEAASVMGVLKLFDRRFGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q408</accession>
    <name>A0A3D8Q408_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_13196</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000027">
        <property type="protein sequence ID" value="RDW56447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q408"/>
    <dbReference type="OrthoDB" id="3514016at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW56447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="551" mass="62799" checksum="74A2BBAE72C9854B" modified="2019-01-16" version="1">MSQGFRVRALWCIYMVISSLLILPISCYFDRGDRFWSGKPQAIGIEFSPTTITAVLTDGLGNFITLATITPTDPEYSTYLHTIFQAGSNWQQPEILHDDLQETAFELKLLEWERWVSSMVERARDRVCSKLPRAIQNMDYIEKKCNPHWVFDPQPPRLRNKAIIAGSRRLQRLQTMLPKWFRTGPPTHPTRSGFLAVLVDILEEVKATALTEHNVTITSAIIARPRWLYNELSDILDEACALAGIESWEQSQDNVEMALKTIEGIGNGSVLLLDHGQYHFNVYYCAWDESAKVVRCSMSIDIRNYASLWIQVALMNRVVGQFHSNVTQEGLDWLQSIEIGSIIREVMTANVDISYGRHWPEDLDIRNRTATVSLRDPTGYVRELNMTGEDVEVVSDRIVDEIRDAIVGLLTIFPDTEKPQEDMTDIASQDEDVSSGEQLKEREATENSTPTPPQVGPRLKKIEHVLVLGSILDIELLGHAAKMTTGAEMIHGPPGMCVVFTETVARGAALYALPWQDHWESTIREYSYEFEDDMYDDEWIWPEEDEEQDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q432</accession>
    <name>A0A3D8Q432_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_13076</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays an important role in cellulose degradation. Shows hydrolytic activity against several glycosidic compounds.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000025">
        <property type="protein sequence ID" value="RDW56611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q432"/>
    <dbReference type="OrthoDB" id="65569at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080079">
        <property type="term" value="F:cellobiose glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000011">
        <property type="entry name" value="Cytosolic beta-glucosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001360">
        <property type="entry name" value="Glyco_hydro_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353">
        <property type="entry name" value="GLYCOSYL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10353:SF134">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00232">
        <property type="entry name" value="Glyco_hydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00131">
        <property type="entry name" value="GLHYDRLASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00056775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW56611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="484" mass="55031" checksum="A89EDCD13808CB77" modified="2019-01-16" version="1">MASDSLEGVLRKDFFWGYATAATQVEGGWNADGKGVSIWDKFAHTSGKVKDGSTPDEAVLSYYQYKSDVALLKQYGVTGYRFSLSWSRIIPLGGANDPINEAGLQYYSNLVDELLANGITPFVTLFHWDTPQALEDRYGGMLDMKSYIPDFVNYARVCFERLGDRVKNWITYNEPGVYTLAGYAAGVHAPARSSNRNLNENGDSSTEPFIVGHTELVSHAYAVQLYREKFQETQKGSIGITLHGNWSEPWDEDDPLDQEAAERAREFEIAWYGDPVYKTGDYPASMRAQLGDRLPKFTAEESKLVLGSSDFYGMNSYTSFYIRHLETPPHIDDHSGNVEKLDTNKQGVSRGPESDTYWLRTSPWGFRKLLNWIWKRYGVPIYITENGTTAKGETAPTEEVLNDQFRIEFFEGYINALTTAVKEDGVDIRSYFAWTFTDNWEWAAGYSDRFGVTYVDFESKEKKRYPKRSAFVIKDLFGKYIAKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q487</accession>
    <name>A0A3D8Q487_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cell wall protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_13197</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000027">
        <property type="protein sequence ID" value="RDW56448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q487"/>
    <dbReference type="OrthoDB" id="3638982at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017765947" description="Cell wall protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW56448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="219" mass="21555" checksum="A69782C43F04AE06" modified="2019-01-16" version="1">MKISFSALAISLLVSSVVAVPAANSASKSASGTASKSASRTASKSASSTKPPGAMSTGNSGSSGTSGPNAAGACSQAVQDLAAGISANIADQRNEVAAVTAVGDVLGEVPMNPVTFAASKASLLDFVNKGIAIRENNQKIAPPGNGAIAGLAIVANAQQAEFNLTNSLTGDAAIDNATVATLKMDFSGGIEQNMKNLAAATANCTMPAAAAARIKMMLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q5D7</accession>
    <name>A0A3D8Q5D7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-xylosidase C-terminal Concanavalin A-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_12947</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the glycosyl hydrolase 43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000024">
        <property type="protein sequence ID" value="RDW56880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q5D7"/>
    <dbReference type="OrthoDB" id="2139957at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18617">
        <property type="entry name" value="GH43_XynB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.115.10.20">
        <property type="entry name" value="Glycosyl hydrolase domain, family 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041542">
        <property type="entry name" value="GH43_C2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006710">
        <property type="entry name" value="Glyco_hydro_43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023296">
        <property type="entry name" value="Glyco_hydro_beta-prop_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051795">
        <property type="entry name" value="Glycosyl_Hydrlase_43"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812">
        <property type="entry name" value="BETA-XYLOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42812:SF12">
        <property type="entry name" value="BETA-XYLOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17851">
        <property type="entry name" value="GH43_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04616">
        <property type="entry name" value="Glyco_hydro_43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75005">
        <property type="entry name" value="Arabinanase/levansucrase/invertase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-xylosidase C-terminal Concanavalin A-like" evidence="7">
        <location>
            <begin position="394"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity, responsible for pKa modulation of the active site Glu and correct orientation of both the proton donor and substrate" evidence="4">
        <location>
            <position position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606710-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW56880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="578" mass="64147" checksum="1CED01F3876F3361" modified="2019-01-16" version="1">MDPLTDDPKASASRWQKDSKSNNISSSCSLLLHGGLTQLVLSLSIDPIHRTIFLPDQLNITTREADTMAGSKMRAVNPIVPGFAPDPSICQIGDTFYLVNSSFHLFPRLPLYSSKDLVSFTHFGNAINRTTQLALKGSTTLLNTGDNGEPMLATGGLFAPTIRHYKGVTYIFCTNAIRDPPNSRKENFFVRTDDILSGNWSDPIYFAYSSIDPSVFIDDDGKAYVQGCTNDSQILCFEIDLNTGETLSEHVTIWPGWNKLYTEGAHIYKKDGWYYLLAAEGGTFEQHMVSMARAKTIFGPYESYENNPIYTAYQTNNYVQHTGHADLFQDASGEWKVVMLGVRKRDGRFIMGRETFLADAEWPEGGWPAVKPTGLEDGAIFETSTRSQLNTVPGVDWVYLRDPYTDKYHIDGANVRVTATTVPLTSPTESPTFIGKRQRSLDGSCTVNVSVPASTDGTPLKAGLALHKDEHRFITLEVDFASKQVSFNFLNKAKDITRSTTCDVPLKEKDVLSLKCSYTETSYEFSYKTNPDGTWETVGKVDTLDMCGYDYIGPIFGIFAIGEGGEVAFEDFAVDKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q681</accession>
    <name>A0A3D8Q681_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">NADPH dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12772</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q681"/>
    <dbReference type="OrthoDB" id="72788at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003959">
        <property type="term" value="F:NADPH dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02932">
        <property type="entry name" value="OYE_YqiM_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044152">
        <property type="entry name" value="YqjM-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303:SF2">
        <property type="entry name" value="INDOLEAMINE 2,3-DIOXYGENASE PYRROLE 2,3-DIOXYGENASE (AFU_ORTHOLOGUE AFUA_5G01450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43303">
        <property type="entry name" value="NADPH DEHYDROGENASE C23G7.10C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="38"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW57322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="426" mass="46650" checksum="6095C6A9D0ECF8C4" modified="2019-01-16" version="1">MGSVSLRNEAAPGAPYFTPYQNPPAGTAVSENHDTIPNLFKPLTIRGTTFPNRAWVAPMCMYSAQDGHLTDFHVMHVGGLAFRGAGLTIIEATAVQANGRISPEDSGLWKDSQIAPLKRVADFVHSQGQKVGIQLAHAGRKASTLAPWLVKRGEKAIARKDAGGWEDDIVGPSAIRWSEEEGMPREMTEQEIRDYVNDFRASAKRAVAAGIDAIEIHGAHGYLLCSFLSPLSNRRTDKYGGSFENRTRLLVEVIEAVRGVIPSDMPLLLRVSATEWMEEQAEESWDVEQTIRLAKMLPALGVDLLDLSSGGNNKKQKIDPFNEFQIGIAGKVRAELHKAGVKNLLIGAVGTITEAEQAKKILDEAPGTIEIRDEQGTLAKADVVLVGRQFLREPEWVLKTAARLGVDVKLPNQYTWAPYPKTLSKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q7H5</accession>
    <name>A0A3D8Q7H5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase C14 caspase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_12587</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q7H5"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="2">
        <location>
            <begin position="3"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW57786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="160" mass="18145" checksum="5AB1DBB170736134" modified="2019-01-16" version="1">MLSLLIGINHYESDGIKDLEGCVNDIEYISTYLQHCLKVPPQSITTLLSPSSNTTPNNMISKTPTLKHIIEALELLIKSAKENESILVHFSGHGTRVPTTHPEFKSNNPLDEALVTMDDTLYTRKLLRDVELDGYLKQMAARKQMYSWYSTAVIREELHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q7L9</accession>
    <name>A0A3D8Q7L9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-lactate dehydratase</fullName>
            <ecNumber evidence="1">4.2.1.130</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_12488</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>methylglyoxal + H2O = (R)-lactate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:27754"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
            <dbReference type="ChEBI" id="CHEBI:17158"/>
            <dbReference type="EC" id="4.2.1.130"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase C56 family. HSP31-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.130" evidence="1"/>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q7L9"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019172">
        <property type="term" value="F:glyoxalase III activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019243">
        <property type="term" value="P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03147">
        <property type="entry name" value="GATase1_Ydr533c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF11">
        <property type="entry name" value="GLUTATHIONE-INDEPENDENT GLYOXALASE HSP31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="6">
        <location>
            <begin position="31"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW57687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="239" mass="25849" checksum="9793F085B5A5BAC3" modified="2019-01-16" version="1">MTPPRRALISITSAQASLFQGKETTGLFISEALHPYNVLTAAGFEVDLASETGSYTADWLSQQPDFLNGSDLEIWNNTNSDFRQKLDHMSKAADLDGSKYGVFYASAGHASLIDYPTATALQKIATQVWTNGGIVASVCHGPAIFANIIDPATNEPLIKGKKITGFTTEAEHSMGIYDELRSWNSEMVEELAARLGATYERGAGVWDDFHLVDGRLITGQNPQSAASTARAVVKAFDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q8M3</accession>
    <name>A0A3D8Q8M3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_12585</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q8M3"/>
    <dbReference type="OrthoDB" id="5424209at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW57784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="196" mass="21802" checksum="3BD685C3988F6501" modified="2019-01-16" version="1">MSSGNTQQRRYVNKHRQVGPKSFRSIPVSLTEEVRSNLEDCTEPNNLREIYKYFSSSPEFEPISSNNLKKGALYIKPPSARIHTFALGGCNGIMSTLYDGDFGLTQEWGFLPVLRAHGNSPLSQRGDSGSSILNNDFTVEGMIWGGDKSAANVDVTYATPISIIIRHVEERMGWVRGSLQRLTSDMDQTIETILEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q9E2</accession>
    <name>A0A3D8Q9E2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_12321</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q9E2"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF812">
        <property type="entry name" value="VPS9 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW58391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="331" mass="35439" checksum="CBA14B803C6F3B97" modified="2019-01-16" version="1">MASDLVFVTGATGFIGAATAMAALKAGYRLRLSVRNEAQIAKLKGIFSEFADKIEYVVVPDIMVEGAFAKVLDGVTYILHLASPLARSTDKNKIFPPAVQGTVGILRDAAKIPSVKKVVIASSIAALVPITGVPEGEVVREDTNWDLSVDTNANFDAGNEFATAMKVYGASKLLANQASWEFMAKERPHFALVSIHPTLVYGHSLTQQSAKELEGSTNGILFSSIMQGPSSDGPLRCVYVGDVADALVKALNPSIKSGSKYLISGQRFTWKDTAEIVEKNFPGVPHKLPTDTNPKVSLVDTSKAEADLGIGWAAPEKIITEVLKQQLPYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q9I0</accession>
    <name>A0A3D8Q9I0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell surface protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q9I0"/>
    <dbReference type="OrthoDB" id="5418436at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021476">
        <property type="entry name" value="Egh16-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618:SF4">
        <property type="entry name" value="CAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618">
        <property type="entry name" value="SURFACE PROTEIN MAS1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11327">
        <property type="entry name" value="Egh16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017620144" description="Cell surface protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW58317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="234" mass="22495" checksum="0CD524445974484F" modified="2019-01-16" version="1">MFSKALIVALAASPLVAAHGKIAVMTGDAGGNTTGLGIQGAVIPGAGTNKQTEVDTTVFNSKAAASDGLGKTKAGPNTLAGMSAVMAQSGNTLAQVTPGGSLTGTVHIVTTDGAGPYSAIVDPTGTGAFSTGTKLDVTTQVPGTKGNIAAPKQRGLITRTLVNLGIVKRASNVNEDYPIAIAVPAGTTCSGSVGGQSNVCLVKIVNPSGAGPFGGVVAMQMAGGAAPAAAPAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QA37</accession>
    <name>A0A3D8QA37_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Glycoside hydrolase family 35 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_12254</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QA37"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009341">
        <property type="term" value="C:beta-galactosidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000135">
        <property type="entry name" value="Beta-galactosidase, putative, bgl35A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.220.20">
        <property type="entry name" value="putative beta-Galactosidase from caulobacter crescentus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040719">
        <property type="entry name" value="DUF5597"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013529">
        <property type="entry name" value="Glyco_hydro_42_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18120">
        <property type="entry name" value="DUF5597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02449">
        <property type="entry name" value="Glyco_hydro_42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycoside hydrolase family 42 N-terminal" evidence="3">
        <location>
            <begin position="50"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="DUF5597" evidence="4">
        <location>
            <begin position="394"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF18120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW58324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="570" mass="63196" checksum="B54DD1A1BF12564C" modified="2019-01-16" version="1">MESHLPFLRNSTSGHQLFIKNDQPFLIRGGQLQNSSLSSADYMKGIWPKLAAAHMNTVLGSVTWEMIEPEEGKFNFDELDKVILGARENGLHLILLWFGTFKNALSTYVPKWVKTDMARFPRAMLRKAGGRMQVADAISIFHGEAAKADATAFSRLMQHLKEFDKNHYTVIMVQVENEVGILGDSRDASAIANSRFESPVPQKLIDFFKNNWDSLHDSLKTNLKTFEKTSYGASNSSWESVFGRSQQTDEMFMAYHFALHVEKVAAAGKEVYPLPLYTNVWQDYAGEDTENEHPVVVGGGGDPGDYPSGGGVVNVLDIWRYFAPALSFVSPDIYLNNYPSVCNKYRHGNQTLFIPEQRRDEYGARRIWLAYGSYQALGTSGFGIDTLSLEENPFKKHYDLVAKVSSHILAAHCSPHSSVGFCFDELPETGKDPSPAVTSTFGKWILKIERSFVFGKPGPGFGMVIHQGGAQFLLIGEGFQVKFSSTSSKAVFTGILSFVEKEVIDEKTGEMRTGRTLGGDETRSGAAAVMPGEDPDYGTFPISVTIPARTRIAECEVYALEVEGSHRLPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QBI6</accession>
    <name>A0A3D8QBI6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Luciferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_12130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QBI6"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF30">
        <property type="entry name" value="XENOBIOTIC COMPOUND MONOOXYGENASE, DSZA FAMILY (AFU_ORTHOLOGUE AFUA_6G01920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW59206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="93" mass="10389" checksum="934EB2BD588F15A3" modified="2019-01-16" version="1">MMILLNAFEMGTVGHNAPGQWKNPEDKSATKRSLEYWIELAKLLERGGFTALFLADIFGGHDTYEGSLDNCIRRAAQWPVTDPTIASYITNVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QCS1</accession>
    <name>A0A3D8QCS1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C6 transcription factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_12138</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QCS1"/>
    <dbReference type="OrthoDB" id="4937900at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053157">
        <property type="entry name" value="Sterol_Uptake_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784">
        <property type="entry name" value="STEROL UPTAKE CONTROL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47784:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW59214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="323" mass="36535" checksum="8198810DDD88F161" modified="2019-01-16" version="1">MLPSTHLPSVNRLAPPSDPSLEERYGSLHICLLYHFEHDHYHHTKSLHPGLKDMLALFMNVGFTTPYLMDELLAYSAAHKSILGQETNQFYLSEATRLQTRALTLYNSASPQISKDTCLPMFLFSSLLSQHVIYNLSCNVHNGLGSILDGLTNSTIIHRGLVAIAKASWPMFSEQIQQQFIRSCQRDYVPIPSSADSRGECDILLSRLNATDMKPESIAVLRSAVENLQDRFDALCTNSSHAMWAAVQDWLVAVPAGYLELLNQRRPEALVVLSHFAVLLHRVAEHWFVGDLGIRLIRLINGHLGPAWEDWLEWPNRTIMERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QI79</accession>
    <name>A0A3D8QI79_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">xylan 1,4-beta-xylosidase</fullName>
            <ecNumber evidence="11">3.2.1.37</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_11300</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>Hydrolysis of (1-&gt;4)-beta-D-xylans, to remove successive D-xylose residues from the non-reducing termini.</text>
            <dbReference type="EC" id="3.2.1.37"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.37" evidence="11"/>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QI79"/>
    <dbReference type="OrthoDB" id="2123594at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009044">
        <property type="term" value="F:xylan 1,4-beta-xylosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044993">
        <property type="entry name" value="BXL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721:SF3">
        <property type="entry name" value="BETA-D-XYLOSIDASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42721">
        <property type="entry name" value="SUGAR HYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017629997" description="xylan 1,4-beta-xylosidase" evidence="12">
        <location>
            <begin position="22"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="13">
        <location>
            <begin position="514"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00026107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW61408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="949" mass="103495" checksum="070AC4FB3A0F4F16" modified="2019-01-16" version="1">MVRTTVVRWLAASSLLSSTHAFLESQSVFQESNSYAPRLKDSTAKDSFLDNIVANMTIPELAMQLHLMFAGNIIGPNADNEMFDFATRFAPEAGVGVLHDLYATNSSQYNSLQKLSIEKSRLDVPFLQFGECLHGVGSYKQSMFPQNIGMAASFDTDLVHRVGRAIGSEARSIGIHACLAPVLDLGLEPRWGRVQEAWGEDMLLTSKMGVAMASGMSKNGSWADPDAVAPVVKHFAAHGSLQGGINGAPSMVLGTRQVMENMLRPFKAVMDLGGVRGVMMAYSELDGSPSHINPMLYEALEDWGFDGFVTADDTGIAMLQYRHATAASPGEAIKQWFNAGGMIQYYDYSVDTFLNATIDLVNNGSVAISTLQSHVRKILDVKYDLGLFENPYIPDEIDSQSLTATNVPLTLEAAQKSIVLLENRNQTLPIKPTAQGIRKLALIGPFGDTLNYGDYSGAYGAYPVSKSSTIRQAISEYLKANASGVELVSSWGVNDWYFNAQRNIPGYLLSTPDGKSGGLLGTYYTDTEFKEAIFQKVEAPNRDWGLFPPNGLPSTNFSVIWEGLLTVPVDGEVEGWIGVALSANTTAKLYIDDELVQHTEMSTESYIQSNIPGIGFTAVNSTSAPAGGTAFTYSPGKVHKIRLEYQVYNLAQKMENSFSLNAEIELFWNLVDQKNPIQKALDIAADADVIILAVGANWDSDGEGGDRATLDLSKNQTELSDAIFALGKPVVMVLQGGRPFAIPEYYAQASAVLNAYFPGQSGGQAISDVLFGVFNPGARIPVSVPRSVGTLPVFYNYKPTARFRVYTDEPWAPVYSFGYGLSYTTFRTSALSISSSSDTTTFSDGDTLFFSVDVTNTGELAGSYLAQVYLLGRRSTTTRPVKQLMAFQRVYLEPGEERTVVMELEVDRYMPVVNLAWQWELEKGEYVFALLEHSGFDADTGINATMVCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QIJ0</accession>
    <name>A0A3D8QIJ0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_11491</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QIJ0"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF218">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0349">Heme</keyword>
    <keyword evidence="1" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="1">
        <location>
            <position position="430"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW61599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="54932" checksum="423295E8DD00A540" modified="2019-01-16" version="1">MASYATLIFVAIAAEFLRRCFLMLKVAFTGPLSKVPGPLSMKISAIPWIWTQVKGAQITKNNELADKYGPIVRVSPNSLLISSKDACQRIIVQEDWKKAPSYDKMNVHPGITSIFTERDKTAYRKKRRLMSPGFSISYLNGLEPKMNACVEDFIDVLKSECQQGNGAAIINIWHVLGNLGLDILAASVLGGPLGLVRSNDQTFRHMFNDRVTKTVMYSQIPFLRYLPFMPAAVSPEWDKMIDRIIADRRAVPKGERQQDLLQLFLDNNEANPEEFTETEVRGEIRVFMLAGSDTTSYSATCALLLLLNNPETFKALMTEIDAEFPALDSDISFEKIQNMPYLNAVISESMRLMPAAAAGLLRVAEKDTFVEGYEVPEGTVTYVMTPRAMHDENIWPDAKDFIPERWLRPYKGKDIDRKAYLPFSGASRNCIGQQYALREMRLILVKLLRRFDVALVPGQSHELRFKIVPQFTSGQYLIKIRPREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QIQ8</accession>
    <name>A0A3D8QIQ8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_11483</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QIQ8"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="87"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW61591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="282" mass="30983" checksum="513602C6B0B21417" modified="2019-01-16" version="1">MTEAAAADGFAEPWLAFEKDMGERFTLHAPLEKMFEQYVGFGTTLMAKSTFPTPDESVKTEDRVISDGLKVRVYTPPDYAGDKPVCLFLHGGGWAMGDLDAEDIHMRLVSKAAGIVIVAINYRLAPMHKFPAQLDDGMTAYHWALSNTSTLKTTPKKCLTFGTSAGANLALALALRIIDEGFEDTLEGVVAVMPVTIHPDAVPAKFKSRYTSYDEHDQHTINSKSAMGAFADAYGAAPEDPYYSPLLHEKLDKLKRVYMAAAEMDTLRDDARLFKFSLDEAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QL59</accession>
    <name>A0A3D8QL59_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">amidase</fullName>
            <ecNumber evidence="3">3.5.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_10834</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a monocarboxylic acid amide + H2O = a monocarboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:12020"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:35757"/>
            <dbReference type="ChEBI" id="CHEBI:83628"/>
            <dbReference type="EC" id="3.5.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.4" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QL59"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004040">
        <property type="term" value="F:amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072">
        <property type="entry name" value="AMIDASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46072:SF5">
        <property type="entry name" value="GENERAL AMIDASE-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001221">
        <property type="entry name" value="Amidase_fungi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="6">
        <location>
            <begin position="87"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="217"/>
        </location>
    </feature>
    <feature type="active site" description="Acyl-ester intermediate" evidence="5">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001311"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001221-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW62532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="563" mass="60329" checksum="FC6F23F986417B24" modified="2019-01-16" version="1">MAPPYHIDDWKSAAAAKRASLQASIPKSHLLPQQLAELAANSVLLPDDPSVLSCGILTPLDLEITSHEDAAILLAAIASGKYTSVQVVEAFCKRASIAQQCTGCLTEILYDSASKRARELDEQLRIEGKTVGLLHGLPVSLKDCYDVEGVCTSSGLVSWLPNQAAKTCSVGRGIIAAGGILYVKTTCSQGMLMVETINNIFGTTANPYNLQLSVGGSSGGEAGLIAAKGSILGSGTDGGGSLRFPAAFCGLWALKPSKGRIPATGVSGVRSGSESVNSALGPMAKPVSGLELWLSAQLLAEPWNYDMSCNPMPWRTVEAERPKKKLVFGLILDDGVVRPTPPVTRALQIVTDAIQKRGHTVITIPQETIFSFHRPSMACTMLSNVQDGGRAIMKHISASGEPVVPRTATGSAASALTTQELFDNHLLRSSLAGKYEAIWQEFGMDAILAPAVAHPAPPHGKYISNSYATIYNMLDYVTGSIPVTAVHPTLDVASQEWYDSKPYDRIEQERFPYDLGDAEMKELYTSPDVFKDSPVGIQVVCRRLREEKCIGILKEIEFLLSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLK2</accession>
    <name>A0A3D8QLK2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Reduced viability upon starvation protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_10939</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLK2"/>
    <dbReference type="OrthoDB" id="2159336at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031097">
        <property type="term" value="C:medial cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990528">
        <property type="term" value="C:Rvs161p-Rvs167p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051666">
        <property type="term" value="P:actin cortical patch localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097320">
        <property type="term" value="P:plasma membrane tubulation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07599">
        <property type="entry name" value="BAR_Rvs167p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000048">
        <property type="entry name" value="BAR adaptor protein RVS167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000189">
        <property type="entry name" value="BAR adaptor protein RVS167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004148">
        <property type="entry name" value="BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046982">
        <property type="entry name" value="BIN3/RVS161-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174">
        <property type="entry name" value="BRIDGING INTEGRATOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47174:SF1">
        <property type="entry name" value="REDUCED VIABILITY UPON STARVATION PROTEIN 167"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03114">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00452">
        <property type="entry name" value="SH3DOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00721">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51021">
        <property type="entry name" value="BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0728">SH3 domain</keyword>
    <feature type="domain" description="BAR" evidence="8">
        <location>
            <begin position="17"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="7">
        <location>
            <begin position="376"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="275"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="149"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="330"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW62637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="435" mass="48979" checksum="01104A3D4D6D0B64" modified="2019-01-16" version="1">MSFKGFQKSVIRAPQTLKAKFNVGEHTKDAVYIDAERRFKELETETKKLHDESKKYFEAINGMLNHQIEFSQAIAEIYKPISGRVSDPDSLVIDSNPEGIKACEEYEAIVRDLLATLQPELEMIETRVIRPADELLEIIKQIRKGATKRDHKQLDYDRHRATLKKLQDKKEKSLKDEKALYKAEADVEQATQEYNYYNDLLKDELPKLFTLEREFIRPLFQSFYYMQLNVFYTLHEKTQGMDIGYFNLNLDIEEAFEAKRGDIQAQAEALTITKFKTTGARRPPGSKWTPPGKLALENKPNRLAIESGKSTYTPPGEKSADVEHPPPPYSSQLSPNLGENSVGRSNSTGVWGAAAKAKGAAPPPPKPKPSRLSGAPAAETATALYDYEAQAEGDLSFTTGDTIEIVTRGATENEWWIGKIKGKQGQFPGNYVKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QMQ7</accession>
    <name>A0A3D8QMQ7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1711-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_11046</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QMQ7"/>
    <dbReference type="OrthoDB" id="4093188at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031011">
        <property type="term" value="C:Ino80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013175">
        <property type="entry name" value="INO80_su_Ies4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28061">
        <property type="entry name" value="INO EIGHTY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28061:SF1">
        <property type="entry name" value="INO80 COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08193">
        <property type="entry name" value="INO80_Ies4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW62744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="28500" checksum="21A2C518B9599A2E" modified="2019-01-16" version="1">MDTTPKAASTSSVRRKSSSAKKKSLLVTLKVSPKELQTFSPLGDTVKEESPSKDSLPTPPAAVDATPTSSAVVEMALDSNSNTPAASGTPVPSSMPPPTEGVKKRGVKRSSGVALGPDGMIIPKVRGKPGPKKKPRLEDGSIDPNAVAPRAAAGTGAHKLGPKANQGAINAGLRALDRSGKPCRKWQKGGFVLKSFTGVVWEIPRWTAPPRGNLKPDENGSATSDSSKENKDSKDSSRLESEKSTSAADPDVASNLVSSPAPAQGPPTPTPMTVASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QPX3</accession>
    <name>A0A3D8QPX3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Anaphase-promoting complex subunit 5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cyclosome subunit 5</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_10357</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. The APC/C complex catalyzes assembly of branched 'Lys-11'-/'Lys-48'-linked branched ubiquitin chains on target proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW63855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QPX3"/>
    <dbReference type="OrthoDB" id="2504561at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037679">
        <property type="entry name" value="Apc5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026000">
        <property type="entry name" value="Apc5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12830:SF9">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12862">
        <property type="entry name" value="ANAPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017830985" description="Anaphase-promoting complex subunit 5" evidence="9">
        <location>
            <begin position="23"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="Anaphase-promoting complex subunit 5" evidence="10">
        <location>
            <begin position="275"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW63855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="776" mass="87507" checksum="6C893C27A6FE4958" modified="2019-01-16" version="1">MTRFLTPAKIGLLILIELYTDAIVPTASTIPILSFVINQILPATHPKASQKLADKSRPLPFVLDLKAFEIMLKTKYPLAVGLPGRSLWDHFLKKLWGIDSLDALHVFFAQRQHLLAKSREDIRQDGEMGISPPSADVILLSRSSPFGSFIRKANVEFERLRFGDTLSLWTGLVRWRQETKSYWSRRHAGLSRWSGDKALHEGIEEWGLDSADMLASIAYGITEQEEGCVSTDDIEKLLEFQVEQMQKLGNRIPVEVKDKFKSVLVDSVIVPSLSHYLNFLDAWKAGDYPTSFDSLHRYFDYTMQNRDRLFYQYALMNLAVLQSDFGCYDEAVAAMLETVSTARENKDMACLNFALNWLYHFGKAHPSSISEAESTNMLGIEREGLAFLRIKAKETGMWTLWSSTLLSEAKLGLSNGESVATAFENILKSSQLTLEKNMRGMIGPQMAMYSSIWGRQGVSLISGQYCELFLRCHAEYSSFDDVLRFTCRIAQLLTDKGKYEEAFERLDGLDSNSLRSWKSNQYWVKYRGLLRLKQDLHRNNLDGADHLLSQLLQCSDSESEPELIFEINLLHIDYLIRRTDYSAALAKVERMVSRLREDGDDLNLSVKLLTIKALLYDKSGRTQKGFSVAIRAASIAWRARLMPALWAAMGAVANILTSLTEFQASSQILIAIIPRALECENCAMNARLYSFLVDAYMGMAGQAPAGSSRRTENLTRCLEFLDRAFGEYSAMEDIKGQQETLAKKATIMRIVGDDVLANDYASAYLDLKKGAGLDVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QRH0</accession>
    <name>A0A3D8QRH0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_10596</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QRH0"/>
    <dbReference type="OrthoDB" id="5305647at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059009">
        <property type="entry name" value="Znf_C2H2_17_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059095">
        <property type="entry name" value="Znf_C2H2_17_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26177">
        <property type="entry name" value="zf_C2H2_17_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26176">
        <property type="entry name" value="zf_C2H2_17_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="175"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="2">
        <location>
            <begin position="206"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW64094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="313" mass="35041" checksum="3CF8A1B8B7BBD57D" modified="2019-01-16" version="1">MVNNTDFNDAQQSYFDLTDLDQNTHLPNIDLSPLPNHDTLQDLNYFPTDTHQAINNSAFSGGGSFSEQSVDQQDVTYGSHLSQYPSSNNWNDQGHTNYVPVDSDGLFSYLDNSQDHSVGTYPGYNMATDTAPIESGHTAGDRPKLQCSVPECSQDREFPSESALQKHEAKHSKPYICQVPNCKHTRFGDKGGLDRHSREVHGSQTHCCPITSCKRHVRGFPRKYNLFEHQKRCHSSPSPDLTPPSIPRQQNHTSDDMTGEQESYESGSSADMATGGGRRLREKLENLYKMRAEIDLDIKALKRSLHLLGEDSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QRH3</accession>
    <name>A0A3D8QRH3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">15-hydroxyprostaglandin dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_10742</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QRH3"/>
    <dbReference type="OrthoDB" id="5371740at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW64240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="286" mass="30764" checksum="050F228047AF7508" modified="2019-01-16" version="1">MAPETKKVAIVTGAASGMGEALATHLVSKGWLVGCFDLQRGPGEKLVAELGENAVFLEVDVANYDSQARGFEAVFSRWGRIDAVLANAGIVDRSSIYILNYRDSDIIPPAPNLACTDVDYKGVVYGTQLAIHFMRKNPTPGGKIVATASVAGIYPHGSYPEYNGAKAAVINFIRGVAPVLKLKDNIFINSVLPGIVHTKIIPQAMVDAVSPAHMTPISTIVEAYEHFLADENQETGEAMECSTDKRILVKQAEYANGDASKRACTVWEPLFKMLHGENSDLETAIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QTP5</accession>
    <name>A0A3D8QTP5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ketoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_09847</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QTP5"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009688">
        <property type="term" value="P:abscisic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="4">
        <location>
            <begin position="7"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW65155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="244" mass="24650" checksum="8E89E4FE14B0DF82" modified="2019-01-16" version="1">MTRLSGKTAVITGGATGIGLAAAKRFIEEGAFVFIFSRRQEALDAALADLGPNARAVKGSVSNLADLDRLYAAVKAERGTLDTVFANAGAGSQLPLGKITVEHCDEILDTNVKGSIFTVQKALPLMGQGGSIILTGSSAGTTGAPAFSLYGASKAGVRNLAQTWAEDLKGTGIRVNVLAPGPTATELAKAALGEEGIKAFAALNPLQRMADPAEIGAVAAFLASSDSSFMTASVVAADGGLAQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QU04</accession>
    <name>A0A3D8QU04_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_10018</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QU04"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="125"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW65326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="216" mass="24704" checksum="3164874C5A0BA500" modified="2019-01-16" version="1">MESLHAFLGMRIFFWRLRKVCEDAHNLNRWKEVVARNFSEPLNDTDFEWLQSSLIPLIEAYPWPGQPALPPVFGAANNLPLHFDLRYLPDAMRPKADRRANEQQLSLRRNIEMRPRFVGPLNDVCPICRDELGNFPHEPVQVTCCRQIFCRACLVSWYDVDPPGAGATTCPLCRAEQVAEAVVDPSPESGTAHNAETPWWIKVLRNDDNMHGERAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QU36</accession>
    <name>A0A3D8QU36_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Palmitoyltransferase</fullName>
            <ecNumber evidence="13">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BP5796_10045</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Palmitoyltransferase specific for casein kinase 1.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Early endosome membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="13"/>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QU36"/>
    <dbReference type="OrthoDB" id="6781668at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031901">
        <property type="term" value="C:early endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF85">
        <property type="entry name" value="PALMITOYLTRANSFERASE HIP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7 12" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="10" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0564">Palmitate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="13 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="389"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="487"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="536"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="148"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="181"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="12">
        <location>
            <begin position="214"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="15">
        <location>
            <begin position="438"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDW65353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="726" mass="80633" checksum="E6C8BEA5A3ED298A" modified="2019-01-16" version="1">MSLIESSAQSTAAPNIPNGKAAAVAPKLSDSNHVELENIPTNERPVNPDEDIMQLARMGDISAIESLYDSGKFDATYCDAEGITPLHWAAINNQYAMCQFLIKAGADVNKKGGESVATPAMWAAQRCHYYTVHLLLEHGADPLVTDVQGYNILHLATFEGNIFLLVLLLHQSIPVDVPDSHGHTCLMWAAYKGYPACVDLFLRWGADVHAADETGFTALHWALVKGSQGCIQKLVEYGADRFAETTTGKTPAITADEMKTSRMWHRALKECGYDENAMPVTISFPMSSWLLKDKRSFMKKFFFFWPFLILWAMLMVSSHMVVFAGIPIALFIGYGLQWVAQQVMEYAPSDMRHFHKTPWLAGIFAATLFWVGLNWLTKILPRTISASPFTNIAFGTMYSLCGYFYFCTMVYEPGFVPKLGGLTQQKTVIDELLSIWKFDEQNFCVPCMVRMPLRSKHCKRCNRCVAKHDHHCPWVYNCIGVNNHRHFFLYLITLEIGISLLVRLTISYYEIIADGASSECNLLGPGFCKVVNADPYTLVVAFWATLQLTWVTMLLFVQLVQISRAVTTWENMKGANHGHGHGSKASEAITSALTAGTTSLAGAQLGHTGLGPDPALPPTHAPRHHHKAGCFAQWKKILGVDTFVETAMHGYEGNRNRRRAARNPFSRGTCSNCKDFWCDPAPVFGKRENGAAVLGGEVINYTMMYEAPSRQSSRGGYQSVGTDDSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QU79</accession>
    <name>A0A3D8QU79_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nicotianamine synthase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_10019</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nicotianamine synthase (NAS)-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QU79"/>
    <dbReference type="OrthoDB" id="1858069at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030410">
        <property type="term" value="F:nicotianamine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030418">
        <property type="term" value="P:nicotianamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004298">
        <property type="entry name" value="Nicotian_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32266">
        <property type="entry name" value="NICOTIANAMINE SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32266:SF12">
        <property type="entry name" value="NICOTIANAMINE SYNTHASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03059">
        <property type="entry name" value="NAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51142">
        <property type="entry name" value="NAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="23"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW65327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="36939" checksum="9D09DC4C6CF2B0D5" modified="2019-01-16" version="1">MDLLRSLFASNVLKSSSIQAPISATGKRQNNHARNKSTPANAEAEQSIGTILQIHATLLARGPALHPCEVVNEAFGQLVGLCARILPESVVSRVREDPRIIDILPSLRHICATAESHLEAYWAAQISEAEDANQALKAFPYYQNYVDLTRMELNSILSISPRKPQKIAFIGSGPLPLTSLCLDMALNGEQVSDHHSPAGLNATGQETIIFNIDQSRDAITQSTALYSKLSPTDDPATPQPMQFQHSEASSPITNLAGFDVVYLAALVGLTVQDKEDILISVVKKMDAGALLVVRSAWGLRGCLYPEFDPTSEAVLQHLNIQLVVHPYNHVVNSVIVARVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUR2</accession>
    <name>A0A3D8QUR2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_10194</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUR2"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="85"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW65502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="406" mass="43870" checksum="626924E712987399" modified="2019-01-16" version="1">MSALLCGIPQFLARRKSKAQENTAYLEGVPVQNEKKTVVSAKVDPFDSASSSASTIAIPPTTAVKPAEKAPETKSQRALTVCSKGKYALVDDFPAPELQHEQEVVIRNYAVGLNPIDWKSVDYNFCLPAFPWVTGREMAGVVERVGSEVKGCKVGDRVWTSTYYRDARAGCFQELVTVPAHTVSHIPSNITFEEAACLGVAALTAGMTLWKWLDVPLPSAPAVTSEEYLLVWGGSAVTGQFAIQMAKLGGLNVIAVCSERTKSMTEELGAKVVTRDGKSNEEIIEELRSIAGENITRVIDLVGNSTAVAALKTVSKTKPVHFAPLAMMKDQVVEGHITVHTVEMKRFVLDEESDKWSQELNALIESGKLRLPKIEVMNGGLEAVEAGLERIKKGDMGGVKVVVSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QV38</accession>
    <name>A0A3D8QV38_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_10056</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QV38"/>
    <dbReference type="OrthoDB" id="5245631at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013268">
        <property type="entry name" value="UTP16"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08297">
        <property type="entry name" value="U3_snoRNA_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="392"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW65364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="428" mass="46937" checksum="07439996E982B902" modified="2019-01-16" version="1">MVSTRRQAAAAEEIQSDVGNTIVVQTPASTSRKRSRKSTQDDMMTPTKRSSPAKKRKLPVPAGNEGEQMETHTHTHIAVEIPVSSVAPNSAKGSSRETSSSSPERKGENNVAPQDGLEIQDSDHDNEDDLVGNMEEKAPRASRKSQSLSAKRSSGKASEEAAAKDFAARPKHRKFGSDEPEIELPETELQIHTAESLESENESSDDEAPEEVVTQNAGQEARRDLKAAAKALEEQESKNRKKRRERDAFLKQQAEKATKKRKQQEDAAGRSMESDASDSEGDNSAAFNVDVANVEASVESPEESSADVLVGVLNKKSAINKRASLPDLLPSEFLDDGESEESDNEVVVEESQRKSKKIKFSDLVEKKPKDLRKGSTTFRVAESRSKLLAPKASIQARKTKEEWIQGRPGKNGAKNRKPFSSGFFVSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QY47</accession>
    <name>A0A3D8QY47_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_09492</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QY47"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF22">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G11320)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="204"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="274"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="401"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="45"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW66743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="487" mass="53338" checksum="349798F26AF8616B" modified="2019-01-16" version="1">MASNEKIGLDNGAHRTPVSINSDDDYSNPTGISEKALLKKLDLKLLPPLTLLYLLSFLDRSNIGNAKLDGLTTDLHITGNEYLFTLTIYFIGYVLFEVPCNIILKRTTPRFWLPTLMLAWGIVATLLGVCQNFAGFVIARFFLGVTESGLFPGVVFYLSMWYKRTETHYRISLFFSAAALAGAFGGILAYGIGFMKGVGGLAGWRWIFILEGLLTVVVSIFAYFFIHNYPSTASFITEPERAFINARLKVSSDATNSEIFEWSSVIAALKDYKCWLYGLGFHTMSLPLYTLSLFLPTIIKNLGYTAAQAQLLTVPPYAVAAFLTVIVAVLAEKTHKRSPFILASSSLAIVGYIILLAAPIHKPGVSYFGTILAATGIYPSCAIVLSWAAANVSGQAKRATATAMTITIGNLGAVLGTQLYRPNTAPRFLLGHAFALGYLCANLMVVGLLWTLLERENYAKRERTASGETGGDQNIISDKDVRWLFQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QY64</accession>
    <name>A0A3D8QY64_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="10">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_09485</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>feruloyl-polysaccharide + H2O = ferulate + polysaccharide.</text>
            <dbReference type="EC" id="3.1.1.73"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the tannase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="10"/>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QY64"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF15">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017494773" description="Carboxylic ester hydrolase" evidence="10">
        <location>
            <begin position="22"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW66736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="558" mass="60612" checksum="5D34BBA6DA536383" modified="2019-01-16" version="1">MFPLLDGGLLVLGLAVPFTLANDLYFPQSHRTRPTGSCNDTFQARCLAFNPLDLVANATVNAHEFVTAGTTLLFPDNDASCARPSQTVSVDVCRIALNISTSGTSGVLAESWFPSNWTGRFLTLGNGGIDGCIKYEDINYGVLNGFVAIGSNNGHNGTGGLAFYHNDGVVEDYVWRSIHTIVEVGKKLTNSFYDATFNHSYYLGCSGGGRQGIKAAEMFPNDFDGIVIGAPAVNFNNLTSWRASFFNKTGAANSTNFISAATWSGLIHDEILKQCDTIDGVADGIIEDPELCHFDPAPLGCGSHSNSTSCLTPAQVQIVREIFSPLYGASGELVYPAMQPGSEQAATQKSYNGTPFSYSLDWFRYVVYQDPTWDDTHFNTTDITAAQALNPFNVQTWPSDLSSYTGASHGGKLLIYHGQQDQQITSFNTPRFYRRLLQGMNLTHTEMDSVLRFFRISGMTHCNSGPGSWMIGQATIGAVSSNNTVGVGFDPKSNVLAAMVDWVENAHPPDTIEGTKFVNDSQAAGVAFKRRHCRYPYRNTFMGGDSTLPDSWTCVLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYI0</accession>
    <name>A0A3D8QYI0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_09632</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYI0"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11063">
        <property type="entry name" value="CYP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047146">
        <property type="entry name" value="Cyt_P450_E_CYP52_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24287:SF1">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 8 9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW66883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="515" mass="58480" checksum="E29942AC68761E44" modified="2019-01-16" version="1">MALQDQHPSLLLALGIVASYALFRIVQYVIMYRKRSIIIRNNGCKPPAKYPHKDPFFGLDLFRENARRLREGKFLDGIIPRYNMVNGGVTTFTSLFLGATIINTIEPENVKTILATKFKDFHLPQFRKDAFRPVFGHGIFTTDGKDWEDSRALLRPNFVRSQVGDLVTFEEHISKLIAKIPHDGATVDLQEFFFMLTMDSATDFLLGQSTDVLSDGNHATGERFSQAFTYVQKKMSLQVRLGKLATLIPDKRYTEAVEFVHKYIGKYVRTALEKGKQYQGAEKEKVQEDGKASRYIFLDELAKTGYSAKKIQDEILNILLAGRDTTANLLSQVFYVLARRPDVFKKLRDEVMQLDGKRPSFEQMKNMKYLKGCLNEALRLRPVLPTNGRIAVVDTVLPLGGGADGKSPILVKAGQNVTFHTWAMHRRKDFYGEDAEEFKPERWETYRPGWEYVPFNGGPRICIGQQFALTEASYTTIRLLQAFKNIEARDSSDWTEELTITLGIGNGCKVSLTPA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYJ6</accession>
    <name>A0A3D8QYJ6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Sterol 24-C-methyltransferase</fullName>
            <ecNumber evidence="13">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Delta(24)-sterol C-methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BP5796_09608</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the transfer of methyl groups from S-adenosyl-methionine to the C-24 of sterols.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Steroid metabolism; ergosterol biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12 13">Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="13"/>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYJ6"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003838">
        <property type="term" value="F:sterol 24-C-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000121">
        <property type="entry name" value="Sterol 24-C-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030384">
        <property type="entry name" value="MeTrfase_SMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013705">
        <property type="entry name" value="Sterol_MeTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF1">
        <property type="entry name" value="HYPOTHETICAL LOC100005854"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08498">
        <property type="entry name" value="Sterol_MT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51685">
        <property type="entry name" value="SAM_MT_ERG6_SMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 13" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="2 12 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 13" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 13" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="9 13" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="6 13" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="8 13" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="3 12 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase Erg6/SMT-type" evidence="14">
        <location>
            <begin position="81"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00038188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDW66859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="378" mass="41994" checksum="2B69F4122C24838A" modified="2019-01-16" version="1">MAPTKLEQEDHTRDAAFNKAMHQNSAQAAGGFSAMMKKDKAAQKAAVDEYFKHWDNKAAKDETAEDRASRVAEYATLTRHYYNLGTDLYEYGWGQSFHFCRFAYGEPFYQAIARHEHYLAAKIGIKDGDRVLDVGCGVGGPAREIAKFTGAHITGLNNNDYQIERATRYAAKEGLSDQLAFVKGDFMQMSFPAESFDAVYAIEATVHAPSLEGVYSQIFRVLKPGGVFGVYEWLMTDNYDNDNEHHREIRLGIELGDGISNMVRISEGLAAIKAAGFELELHEDLAKRPDATPWWYPLAGEFKYMGSIYDFPTILRMTKVGRGIVHKFVGVLEALGIAAHGTQKTADSLATAADCLVAGAKQDLFTPMYLMVARKPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYW4</accession>
    <name>A0A3D8QYW4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2 type master regulator of conidiophore development brlA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_09694</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYW4"/>
    <dbReference type="OrthoDB" id="3545083at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="326"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="91"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="170"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="110"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW66945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="387" mass="44138" checksum="139A081A62EB4EFE" modified="2019-01-16" version="1">MVHQENSHYQSYPPFGSNTLSFSSQQYSLSSQYSTTQQLPKPASRQDEYHLYPMPESHDSSQHVHRHIGANFEMEQYQSLTITRTSQYDSFDDCCDNEPTYEPIPSSGGENHHEQRDENGRSGSFEAPYMTNEYAAQYDSLLAASNQVSGRAATLLYRITANTQENVNSNGWSLPGGFRSLSLDTPPKGRNPTIPSGDQPRSESICPKTQYHPTYNTIGDESLTSIGRNISISFDSTAYSPVTVPNLPNSRTTSATLEGVYHPPIYAQNQQQDAIVPTDGQEAELTARYGPMKCEVGHCKDKPERVVYRTYKDYRKHIHNVHLKPFSCPRRNCNKTFSKRADFSRHTLTHTRDKRYSCKHGSSCPRRVTEFSRYDKLKSHMKRWHQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QZ57</accession>
    <name>A0A3D8QZ57_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_09717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QZ57"/>
    <dbReference type="OrthoDB" id="3437257at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="2">
        <location>
            <begin position="69"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW66968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="385" mass="44110" checksum="F8086C411D9EE5D9" modified="2019-01-16" version="1">MASLSPQVQQTGQIEPISSLPGLTPDASQPSRKSDPEYLLRNSINTDKSFNFCYDLYKYKPLGHKLTKFHVFAKLPLEVRCIIWNAALPGPRLLYLQTQKVLCEVEGGEEDGSTFEMVAGVKKCGRHLTLLATTQESRWVTMKSYKALLPQAPYVPSPDDTFKHSVNVFVDFKIDTLCTILDFALLDFLNTCPGLKIKNLALIITELWPSDSESWTYLLGCLPQIQNLTFVLGVPKDRALFTYRDTHERALMGQLPCLNNILNCWPDEMPDFWSSLALYERLLLDEEIRDAFTDFVRDNPQWDRINFNTTMYMEKEEGSCIWRGFLETEMPRIDWVLEYAFVVAELGRIRPMGEIYPWVAESFCFDNGRLLTPSAGPAVNIIRFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QZ72</accession>
    <name>A0A3D8QZ72_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QZ72"/>
    <dbReference type="OrthoDB" id="10383555at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW66961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="214" mass="23559" checksum="431AE54E748E80D4" modified="2019-01-16" version="1">MFTASHTAAEKNLDYKPKCKSPTSPSPTQAPGTTQSVLTPGEPDGKSHALCANLDPPTQPAKTGPDASQLTMTSDHDLMSEDRCQCYPTLTSPNRHVHFTNTPATTAKELLKVAAGDLALRPSLRKRELSIEIKITPNTEIHVADEVAAKLKYAAELVYRRDLRRFNKPCVMRGVRKGMRMPSIHPGKRKMGGEGVVDVEMGNGEEQRMQIREK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R302</accession>
    <name>A0A3D8R302_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytidylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_09013</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R302"/>
    <dbReference type="OrthoDB" id="5673at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037997">
        <property type="entry name" value="Dgk1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31303:SF1">
        <property type="entry name" value="CTP-DEPENDENT DIACYLGLYCEROL KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="225"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="282"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="346"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="375"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW68356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="393" mass="43026" checksum="080EA2988CB375E7" modified="2019-01-16" version="1">MSVSRSNPIPAFPRVISPSPTPSQQSDSDGYFGPVTRSAKKRRAAETSQAVISETIDEDEDDEISAELRRARSKSRSPMRGTLRKVNGITPVKASSASSKTKSIAATNGQAPNGHLSPTSASPAGWSWRDISRSPSPLGLIPIHRHWRTFVHKHEVPRKVLHVSIGFFTLWLYVSGVQTSKITPYLMSALVPILTADYLRHNYASLNRLYVRLLGALMRESEYQGYNGVIWYLLGAWIVLGFFPKDIGVMGILLLSWCDTAASTIGRLYGRYTPRVRRGKSLAGSLAAMAVGVFTAWAFWGWLAPRTGPFPGDEDFPFMFTGSLSLPGAVRDVIGLDREQATISGGWALGVVSVWTGFIASASEVVDLFGWDDNLTIPVLSGMGMWGFLRLFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R338</accession>
    <name>A0A3D8R338_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 19">Mevalonate kinase</fullName>
            <shortName evidence="19">MK</shortName>
            <ecNumber evidence="3 19">2.7.1.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BP5796_09104</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="19">Mevalonate kinase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway. The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17065"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:36464"/>
            <dbReference type="ChEBI" id="CHEBI:58146"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.36"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:17066"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="18 19">Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 1/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 19">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 19">Belongs to the GHMP kinase family. Mevalonate kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.36" evidence="3 19"/>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R338"/>
    <dbReference type="OrthoDB" id="1652964at2759"/>
    <dbReference type="UniPathway" id="UPA00057">
        <property type="reaction ID" value="UER00098"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004496">
        <property type="term" value="F:mevalonate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019287">
        <property type="term" value="P:isopentenyl diphosphate biosynthetic process, mevalonate pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000027">
        <property type="entry name" value="Mevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.890:FF:000003">
        <property type="entry name" value="Mevalonate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.890">
        <property type="entry name" value="GHMP kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013750">
        <property type="entry name" value="GHMP_kinase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036554">
        <property type="entry name" value="GHMP_kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006204">
        <property type="entry name" value="GHMP_kinase_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006203">
        <property type="entry name" value="GHMP_knse_ATP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006205">
        <property type="entry name" value="Mev_gal_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00549">
        <property type="entry name" value="mevalon_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290">
        <property type="entry name" value="MEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43290:SF2">
        <property type="entry name" value="MEVALONATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08544">
        <property type="entry name" value="GHMP_kinases_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00288">
        <property type="entry name" value="GHMP_kinases_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00959">
        <property type="entry name" value="MEVGALKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55060">
        <property type="entry name" value="GHMP Kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00627">
        <property type="entry name" value="GHMP_KINASES_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 19" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 19" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 19" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14 19" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 19" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 19" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="16 19" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13 19" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="15 19" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="6 19" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GHMP kinase N-terminal" evidence="21">
        <location>
            <begin position="220"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="GHMP kinase C-terminal" evidence="22">
        <location>
            <begin position="392"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="20">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="20">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00029310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU363087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF08544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="RDW68447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="538" mass="58210" checksum="1934C74A1A66006F" modified="2019-01-16" version="1">MSSGSSKKSTGSASIQLKKPHSRSSSSSTTSVPISTPPGSSPSTSPPLRMSRLDTGVAINGISADMENTDLASTADARKKALQRKQSTPMMPPFLVSAPGKVIAFGEHAVVHGKAAIAAAISLRSYLLVTALSKSKRTVSLRFPDINMSHTWNLDELPWSIFSQPSKKKYYYDLVTSLDPELVAAMKPHLADVSSHAPEDIRKVHQSSASAFLYILLSLGSQSFPGCLYTLRSTLPISAGLGSSASISVCIAAALLLQIRTLSGPHPDQPSEEARLQVERINRWAFVGEMCIHGNPSGVDNTIATQGKAAMFIRKDYSRPPSVKPLWNFPELPLLLVNTKQSRSTATEVAKVATLRKTHPQITDSILHAIDKITEEAAELITNEDFDKDEMSSLEALGKLMTLNHGLLVALGVSHPRLERIRELVDHEGIGWTKLTGAGGGGCAITLLKPDVSKERMQRLEATLEEEGFGKFETTLGCDGVGVLWPAVLKNGVDDDYGDEIDQEKFLNADGIEGVEQLVGVRGYTGERDAWKFWRVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R3D2</accession>
    <name>A0A3D8R3D2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">EXS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_09212</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R3D2"/>
    <dbReference type="OrthoDB" id="2159384at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF46">
        <property type="entry name" value="PROTEIN ERD1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="98"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="6">
        <location>
            <begin position="190"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW68555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="423" mass="47662" checksum="0C775541E4D465EF" modified="2019-01-16" version="1">MDGDPAVENELDSFSLTLPLPYRIALAIVLGVWAWGVNLQYLSRAKIDVPSLIQYPARQSHTQPPHHLATYRLALILSLPLGFSLLLFWALSRRTPELVIYYDFLPMSYLCLLAAVFVAPVRQFSLMGRRRFLSTLKRVSIGGIAQTGDGKFGDILLADVLTSYAKILADLFVALCMFFKPSGSATKRPDRACGGQYLVPIIIAIPSIIRFRQCMIEYLRVRAMNQKNGGIGAAGWGGQHLANALKYATAFPVIIFSALQRNLSLNHEHVGMTETGLYRAWLAAVFINSFYSFYWDVAKDWDMTLFSSARSSPKYPFGLRPRMYFASTEFYYGAMITDLLLRCTWSLKLSPHLDHFADFESGIFLMEILEVGRRWLWIFFRVETEWVRSTSAGDRLQGGFGLPGQDDVLMGDYGSGKDDSDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R421</accession>
    <name>A0A3D8R421_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter-21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_09221</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R421"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000034">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000068">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF19">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01812)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="65"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW68564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="510" mass="56749" checksum="6613A9891B985583" modified="2019-01-16" version="1">MATKDNFPVSNSHSNGHSNGSDDEKVLAGLGEHQEDTIDDPDAHMSAEEKAAIDKRLVRKLDFTIIPWMCCLYLLAFLDRTNIGNAKIAGLQADLHNMSTGKYNATLSIFFVSYSVFEPLTNVLLKRLRPSIFIPIIMVLWGITMTFMGFVMNWSGLMAARWFLGLFEAGLFPGIMYYLSCWYKRSEFGIRSAIFFSAAAVSGSFGGLLAAAIENMDGLGGRPGWAWIFILEGILTVLFGIGSVWMVHDFPDLATFLSVEDRRRVIRRLKMDQQSSAEHEEFKMKYVWLALKDYKTWLFAIIYMGADMPLYAFSLFLPTIISQLGFTTTRAQLLSVPPYAAAAILTILIGWIADRTRQRGLCNIGVSLLGIAGFAMLLGSQKAGVKYAGTFLGALGIYPCIANTISWASNNVEGVYKRGVVLGLVIGWGNLNGIVSSNIYFQRPKFTVGHAVVMAYMIACLFGGSVAMHLLLRRENAARRAGKRDHWVEGLNEKEREVLGDRRPDFFYTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7D6</accession>
    <name>A0A3D8R7D6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_08324</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW69927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7D6"/>
    <dbReference type="OrthoDB" id="1405469at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000306">
        <property type="entry name" value="IKS protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000699">
        <property type="entry name" value="Probable serine/threonine-protein kinase iksA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF138">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE IKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="150"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="40"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="87"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="465"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="267"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="465"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW69927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="669" mass="75007" checksum="41700558F859F9D2" modified="2019-01-16" version="1">MSLVPYSSRDSREIVLRHDDAIVVRDPLTQQLMLRGASPDLSLSECPTCHRPFRSSSPERKPSPHRQNVHQTAFISPEYFRMLQHVNDGPEQQSPPSSPIRRLVQPDFSSPGSTGGSVADAEFVASTPDPHAGHHIKRDAFSPNYFRRFFIEEKELGRGGKGVVLLVRHELDGVSLGQFACKRVPVGNDHAWLEKVLIEVQLLQGLSHPNLVSYRHVWLEDVKLTRFSPSVPCAYILQQYCNSGDLLHYIAGPGPVMTSTNEQLKEQMRRKSRGRSERPDMKPSQRKLTFEEIYSFFKDISSGLAHLHSSNYIHRDLKPSNCLLHRDGNEFRCLISDFGEVQAENVVRKSTGSTGTISYCAPEVLKQDAAGRYGNFTTKSDIFSLGMILYFMCFGRLPYKSADCIQEEYEDIDTLRAEISTWTGFQDERRERPELPNQLYDFLKRLLAVDPVNRPSANEIMHALRTEKGLETPSRRNSGNGPALGARRIHSLDPPNLSDNPHKEPRRAHSGAYIEDAPSETSITPPSSPNLQRKGVAGSSSSTSRPNSPPLLMAPPTTRFSAFQNRIAVYEHHVRSWMMLNAQTLLLLMRLVSFSIKMYLISGPCLPAGTRPIVGYPLMLLAALEVGLGANVDLRISAVLFALHALVVTLGMRRGVLCAERVELHWMDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7V5</accession>
    <name>A0A3D8R7V5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_08516</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7V5"/>
    <dbReference type="OrthoDB" id="3542620at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW70119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="226" mass="26137" checksum="5B74A317F730B0F6" modified="2019-01-16" version="1">MGRRHYELALDRNWFPSPEDLRDVGDLERMSRRNRALAFRVEQKKRVYVDFQRDLLVGQNPVAGRRSKSLLSIPDHPRHRHFPVDGLHGLETGEWLVWSKGFSMEIFKMRMAHDVLSKIVLFAVMMPIPSDDIADWRVLVIKDPFVPFLEGRGVDRTNCSMDRMPDLGQRELLRALMGERELAMALKDGTLWDCAVDGKVDAEKADVDSEIQLAYDIFETQIGWTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7W5</accession>
    <name>A0A3D8R7W5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_08532</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7W5"/>
    <dbReference type="OrthoDB" id="431212at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005345">
        <property type="term" value="F:purine nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015853">
        <property type="term" value="P:adenine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015854">
        <property type="term" value="P:guanine transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045018">
        <property type="entry name" value="Azg-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006043">
        <property type="entry name" value="NCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337">
        <property type="entry name" value="XANTHINE/URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43337:SF1">
        <property type="entry name" value="XANTHINE_URACIL PERMEASE C887.17-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00860">
        <property type="entry name" value="Xan_ur_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="103"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="155"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="187"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="248"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="485"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="612"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="612"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW70135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="632" mass="67810" checksum="A6D0611EA6F3E8F1" modified="2019-01-16" version="1">MGWVQRTNTAVARSPVGVWFRLEHSGHRKERKGTRFLTEIRAGLATFFAMAYIISVNASIVASTGGTCVCENAPDTADPYCTTVNTQPYDNYEACRQILNRDLVTATAAISALSSFCMGLFANMPLALAPGMGLNAYFAYQVVGQNGQGVVPYRLALTAVFVEGLIFVALSILGIRQWLARMIPLSLKIASGAGIGLYLALIGLTYNAGIGAISSGSSDPLELAGCVPALLDPVTGICTSGKMRNPTMWLGIFAGGMLTAFLMMYRVKGAIIVGVLVVSIISWPRNTTVTAFPDTDSGNNAFEFFKKVVSFHPIKKVLAAQDWNITGPHTGQFALALITFLYVDILDATGTLYSMARFCGVMDEDTQDFEGSAVAYIVDAFSISVGALFGCPPVTVFIESGAGISEGGGTGITACVTGICFLIAIVFAPIFASIPAWATGCTLILVGAMMARAVTDINWRYVGDSVPAFVTLAVMPFTYSIAYGLVTGIVTYTVLNTGVWLLMKASGGRIIPYDYEQKDYWSYKGRGGLLPGWLKRLARGKKDFWRDYDFDAEELGSHDSYGLSIKRDSNANRTSGTSARGVEADLPVTGDRTWELPVMSITAAYNFRSNRSATSREASVMSSSERDSVVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7Y2</accession>
    <name>A0A3D8R7Y2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_08560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7Y2"/>
    <dbReference type="OrthoDB" id="14535at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW70163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="57" mass="7046" checksum="097461D45AAD75BD" modified="2019-01-16" version="1">MVINPTYLAQRTRQSVNWADAHRRVLKSYREWLRSVRFPPSSVHEYRRDFSSLRLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8Q6</accession>
    <name>A0A3D8R8Q6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Phosphoacetylglucosamine mutase</fullName>
            <shortName evidence="14">PAGM</shortName>
            <ecNumber evidence="4 14">5.4.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12 14">Acetylglucosamine phosphomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11 14">N-acetylglucosamine-phosphate mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BP5796_08763</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23804"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="5.4.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14 17">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="14 17">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.3" evidence="4 14"/>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8Q6"/>
    <dbReference type="OrthoDB" id="1928at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004610">
        <property type="term" value="F:phosphoacetylglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03086">
        <property type="entry name" value="PGM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000003">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000013">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000023">
        <property type="entry name" value="Phosphoacetylglucosamine mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049023">
        <property type="entry name" value="AMG1_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049022">
        <property type="entry name" value="AMG1_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016657">
        <property type="entry name" value="PAGM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955:SF1">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21405">
        <property type="entry name" value="AMG1_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21404">
        <property type="entry name" value="AMG1_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016408">
        <property type="entry name" value="PAGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 14 17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 14 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="19">
        <location>
            <begin position="55"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="19">
        <location>
            <begin position="117"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="21">
        <location>
            <begin position="204"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="20">
        <location>
            <begin position="300"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase C-terminal" evidence="18">
        <location>
            <begin position="455"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="15">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="17">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="375"/>
            <end position="377"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="500"/>
            <end position="504"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="509"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00059527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR016408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF21404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF21405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RDW70366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="539" mass="59036" checksum="1A0A860A3BA56C93" modified="2019-01-16" version="1">MDAKILEASQKHPKPDLNFQYGTAGFRMKANLLDSVVFRVGLVAALRSRKLGGQTIGVMITASHNPPEDNGVKLVDPMGEMLEQAWEVYSTELANAKTEDVPEIYHKLEKSLKIDPKTPARVIYARDTRPSGPALVRSLVDALEAVGAEYTDYKLLTTPQLHYLTRCTNTEGTPQSYGEVSEKGYYKKLGAAFARAMKGKKARGPVIVDCANGVGGPKLAELLKYLPPASEGLEIKIVNDDVLKSEILNSDCGADYVKTKQRAPPSSKAGPNERCCSLDGDADRIIYYFNDPTHGFRLLDGDRIASLSASFIGDLVREAGLAEDLKIGLVQTAYANGASTKYVEKTLKVPVVFTPTGVKWLHHAATKFDVGVYFEANGHGTIVFSDQALKAFNTKDPQSPAQKNALETLRALTELINQTVGDALSDMLLVETILAHKSWTPKEWDSTYTDLPNRLVRVEVPDRSIFKTTDAERKLSAPEGVQTQIDALMAKFKDGRAFARPSGTEDALRVYAEAATRSEADDLANKVSDLCKREGERYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8T6</accession>
    <name>A0A3D8R8T6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF7908 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_08767</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STIG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8T6"/>
    <dbReference type="OrthoDB" id="439917at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057230">
        <property type="entry name" value="DUF7908"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006969">
        <property type="entry name" value="Stig-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33227">
        <property type="entry name" value="STIGMA-SPECIFIC STIG1-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33227:SF48">
        <property type="entry name" value="STIGMA-SPECIFIC STIG1-LIKE PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25485">
        <property type="entry name" value="DUF7908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04885">
        <property type="entry name" value="Stig1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017571901" description="DUF7908 domain-containing protein" evidence="3">
        <location>
            <begin position="22"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7908" evidence="4">
        <location>
            <begin position="119"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW70370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="537" mass="55031" checksum="6054A3612EDF6A87" modified="2019-01-16" version="1">MFSPALLATSLLLAAIPAARGLDTARRDHYCVNGSGVVEIESPLVSYKPVFINSYIAANTIININGGVVIDINNAPTFLSTVVTATVLATTTATLTSTVTARTTVTKTSSTVVETVTITPSTFVIQVVPIIVTKRQQGNNTFYLTASAALVQDNNLASLFTIINQELFSGGQKISTTFPGNSSALFQVGGSGNITTTFSNVGNVFMWNNPAFTNGAKATFCLLGEILHVIFDGSSIDSCVPASLYSLPSPSELRNTSSIVNTSTSQLSASSSFTDASSSALKTVPSSTAIDSSTTTPITSTPACTDTQLLCEGVCVNQTESLCGSCTNSCVGHVNPFGQAYLCDTSLFNMLTRRYGACASVSLLGGNCNDAGGDCGSDAGLCSPAGYCIYEIADTLNCGVIGNICVEPYGTCNWSCVDLQTDSSNCGAVASQCAQEFGVIDSCAAGTCVSLVNNATNCGACPTGATCSSGTCINLAFDANNCGAFGNVCPSAAPSCVKSQCVDLNVDTSNCGYIGDKCNPNETCQSGLCICGTSDGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCN2</accession>
    <name>A0A3D8RCN2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Conidiation-specific protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_07843</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RCN2"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019626">
        <property type="entry name" value="Stress-induced_KGG_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10685">
        <property type="entry name" value="KGG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW71809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="9136" checksum="8527F82F8303EC5E" modified="2019-01-16" version="1">MEPTDTYNPGNFANRPHEEVVDAAKKGGHASHGGVEEVAAGNGNSGNVDAAKKGGMEEVAAGNGNPGNFANRPHDEVVDAAKKGGKASAII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDI7</accession>
    <name>A0A3D8RDI7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cell cycle control protein cwf19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_07968</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWF19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDI7"/>
    <dbReference type="OrthoDB" id="2113965at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040194">
        <property type="entry name" value="Cwf19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006768">
        <property type="entry name" value="Cwf19-like_C_dom-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006767">
        <property type="entry name" value="Cwf19-like_C_dom-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072">
        <property type="entry name" value="CWF19, CELL CYCLE CONTROL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12072:SF5">
        <property type="entry name" value="CWF19-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04677">
        <property type="entry name" value="CwfJ_C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04676">
        <property type="entry name" value="CwfJ_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cwf19-like C-terminal" evidence="4">
        <location>
            <begin position="429"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Cwf19-like protein C-terminal" evidence="3">
        <location>
            <begin position="560"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="118"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW71934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="669" mass="77068" checksum="9A3C2D168D79F7AF" modified="2019-01-16" version="1">MDGLDEFEKTLAAEKALREKSEKDKDRKHKHRHRHHRSRHDEDEQEHHRDGHRDKRSRHFRDDEDDDQRRSRKHAKVSDPKEDLPIPDEEAHASPTPVRDSWMTAPSALDIDYTQKGVKKERPAPPKKADYDLKIHKNELNAHLQDLADGKKLEDISDGEDTEEVSYIFGDSGSQWRMTRLKAVYKQSEQSDKPIEEVAIERFGSLREFDDAREEEIEMDRRNLYGTGYVGKEKPSGELFQARKLNLDTRKDHEHARGTIPELPQGLVIEQEPPRTVAIDQTVLNRLKAQLMKAKLRGSSDVPRLEAEYEKAAAGFVPSTQPDMVILGAMENRLLAGTRGEVKAIDNKRGRERGLVEENEDMSIEDMVREERRTRGQAGGEGMRAAERIAKDGKFDTDLDYMDDNANKLAKRVQKSEINLKNAAVSDFQKMNRILDNCQLCHHEEKNEPPIAPLISLATRVYLTLPTEPELSEGGAVIVPIQHRKNLLECDDDEWEEIRNFMKSLTRMYHDQGRDVVFYENAAAPHRKMHAAMQVVPLPYSLGETAPAFFREAILSSDEEWTQHKKLIDTAAKARDGLGKSAFRRTLAKEMPYFHAWFTLDGGLGHIVEDSNRWPKGDLFAREIIGGMLDVEPDVIKRQGRWHRGADRRLEGFRKRWRKFDWTRVLTDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIC4</accession>
    <name>A0A3D8RIC4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_07120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIC4"/>
    <dbReference type="OrthoDB" id="10472486at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW73678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="261" mass="28339" checksum="397B80C529402988" modified="2019-01-16" version="1">MATDSSCEPTAGPQSPPTVYWTRASGAVMQDVLFCTHGNSMSNRACIPVLGPSAPPIIVWDCTVAIVDKSIAQQSSNCSRDLPGPVTALHLHVVNLASTRDTRNSPRAAKEKYPSSQPPIETRYKKPARPAMATCKSQATTLDRPRAVNKPPRAKAKGETKGFHASRRSWYRPRTQDQRQGAVGACVAHTKRPRLASSLVAEIKPGLRSGPTRETRIARCTRPTREGQENQEMRALLVPTSYAARAGLAYGKSAREERVSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIQ0</accession>
    <name>A0A3D8RIQ0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Bilirubin oxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_07292</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the multicopper oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIQ0"/>
    <dbReference type="OrthoDB" id="262547at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13889">
        <property type="entry name" value="CuRO_3_BOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.420">
        <property type="entry name" value="Cupredoxins - blue copper proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011707">
        <property type="entry name" value="Cu-oxidase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011706">
        <property type="entry name" value="Cu-oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045087">
        <property type="entry name" value="Cu-oxidase_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002355">
        <property type="entry name" value="Cu_oxidase_Cu_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008972">
        <property type="entry name" value="Cupredoxin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48267:SF1">
        <property type="entry name" value="BILIRUBIN OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48267">
        <property type="entry name" value="CUPREDOXIN SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07731">
        <property type="entry name" value="Cu-oxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07732">
        <property type="entry name" value="Cu-oxidase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49503">
        <property type="entry name" value="Cupredoxins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00080">
        <property type="entry name" value="MULTICOPPER_OXIDASE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0186">Copper</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017814892" description="Bilirubin oxidase" evidence="5">
        <location>
            <begin position="19"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="7">
        <location>
            <begin position="74"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Plastocyanin-like" evidence="6">
        <location>
            <begin position="371"/>
            <end position="498"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW73850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="590" mass="66203" checksum="2ACFA41D3739EF1B" modified="2019-01-16" version="1">MFFFLAFITAIFSTAAEGAGGGNQLSPVYNHFYEFPLPVPPVKTPLTTYTRADGSKVDYYEVHIKPLTQQVYPGLQPTKLVGYDGISPGPTFHMTFGTEAVVRFINEGNDKPTVTHLHGSITHPPWDGWAEDTIPVGFYKDYYYPNAQRARTLWYHDHAIDHTAENAYFGQAGFYILTDDDEKASGLPQGKYDIPLSFAGKQYDANGQLVSPATQPGVSLFGDVIHVNGQPWPFFNPEPRKYRFRMLDTSISRAFRLYFVTDLSIKEDDTAHHIPFYVVGSDSGRTSKPVLTPDLWISIAERWEVVFDFAPYAGKTVYLKNFLVTQADTPYNNTDQVMKFNVGTTVTDNSNNGPMPASFAPLPLPPQKDLAKPDHIFEFETKNGEWKINGVTFNDVNNRVLAKPPRGSVELWKLVNKSGGWSHPIHVHLVDFQVVSRQKGARGVQTYEAAALQDVVLLGQNEEVYVLARYTPWDGLYMFHCHNLVHEDHAMMAAFNVTDLPNFNYPPQTSKFIDPVDPRFTSRPYDASVQTLDFVKANALPNLANLNAYVNHESVEAALVNFYATATSTISDAAPVQSEFNGKRRRSYPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RQ06</accession>
    <name>A0A3D8RQ06_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycosyltransferase family 8 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_06960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RQ06"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW76139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="41811" checksum="FEB0E7241556242F" modified="2019-01-16" version="1">MVPEWNGFPKNNPPFYHRAIVFGRSISNTRFTFLAAISLTIIYLVSSASSFSSTIALADISSLKRPEERLAYATYLAPTRPEPENDDDDKYFVACRMVAYQIMHASETKTNRSIPFVVMVHHELRQSKKDRLKRDGAVIVEVEGIRPEEWMMSGMMEKYMDLYTKLRVFQWVQYDRVLFIDGDHLIVRRLDDIFDTPEATMIQQNHKNNSALLDGEAGQPSEYLLAASGDLHSYDHPFPPPNIGAFNTGFFLFKPSIQLFAYYMTLMKLPNSHNPEYPEQALVNYAHRPEGNMPFAQFDWSWNIILPNGNDWKWENRAASFHEKWWRTRAVREVREELRVVRESMLAFYRGHDEASWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVP1</accession>
    <name>A0A3D8RVP1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Threonine aldolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_05975</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the threonine aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVP1"/>
    <dbReference type="OrthoDB" id="10261951at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006520">
        <property type="term" value="P:amino acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001597">
        <property type="entry name" value="ArAA_b-elim_lyase/Thr_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097">
        <property type="entry name" value="L-THREONINE ALDOLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48097:SF5">
        <property type="entry name" value="LOW SPECIFICITY L-THREONINE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01212">
        <property type="entry name" value="Beta_elim_lyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aromatic amino acid beta-eliminating lyase/threonine aldolase" evidence="4">
        <location>
            <begin position="44"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW78123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="383" mass="41916" checksum="BF3CB00564F7E61B" modified="2019-01-16" version="1">MLLLLLTRYSPEKKSRRQQLKAVRNEMATYSFRDDYSDGAHPDIIAAIGRANTPNQMPYGEDSYSANAKKLIKEKMNAPGAEIYFVTSGTLANIIAIGSCLRSYEAVIAASSGHIVVRETGAIEAIGQKIINVDPVHGKLTPAGILKALGDNLHFPHMAKPRLVYISNTTEVGTVYSKTELETIAQLCRAHGLLLFLDGARLGVALAAEQNDLTLEDYGRLTDMFWIGGTKVGALMGEAIVINNPTLQEDFRFHIKQRGGLLAKGGILGSQFEELFRGDLYYTLASHANLMAKALSDGLQEVGFRLTERTASNQVFAILPNALIKKLQADFAFYIWNTLDGKQSVVRLITSWSTEAKQVQAFIKMLQVGGVPTEHATAADELQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVQ0</accession>
    <name>A0A3D8RVQ0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_05908</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVQ0"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051836">
        <property type="entry name" value="Kremen_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269">
        <property type="entry name" value="KREMEN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24269:SF16">
        <property type="entry name" value="PROTEIN SLG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017698529" description="WSC domain-containing protein" evidence="7">
        <location>
            <begin position="24"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="8">
        <location>
            <begin position="48"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW78056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="183" mass="18684" checksum="55E1DD574F24F74C" modified="2019-01-16" version="1">MALFPLLQPFALLLLLLCQSTSAQSTTTTSAASTTTSTAATIYPGNSKYTYLGCYNETTTLNNTAMTRALQGTSESNDTMTVEVCLAFCAGSTYAGLEYTKECYCSPYISALSVKLDDAQCNLPCVANGSEICGGALKVSVYQLKSSTSTGKSAAPGSMGGSGRAAAGSALALGAVVGGLLWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVV8</accession>
    <name>A0A3D8RVV8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_05987</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVV8"/>
    <dbReference type="OrthoDB" id="5428038at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW78135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="728" mass="82314" checksum="896AC47031D00B26" modified="2019-01-16" version="1">MECRRRSGKRRMAYTTQDFRPPAHFLAALWGPGGDVDITQWQWEAPVSRPLPDVANTRRMLPKWLADWNKQEQELENTNGNATYLQVTPIHTPGALEDMFRQFQRSLQETGPSKIDEIFEEFQKQLSYSLSLGAVSDEMLSSVLQETPRSLANFWQHRALLDEKDATGLTYSALCGQLLLPLYISIWGSLKACKVLQPVDHDSGVMADLFSAIAPFAAKEETQIVLRDILQLTSSKQHHLMESGIVSMVRHWTMSWLKNTVVDSTSSIAKAEQASALTELLTRECDKKVRDLEGSVDPATGGTSALESLNNARLSITTTLRAIKLAQNILEPWKASSGRLAEVLDLLPTILISKLLPEFCDPGAMAHVLWYKLRYRMLLTFANMRYIDDDHLIKAWLKFEAVVPNTSRCYEGLRTTPPLSTRESCEIILNHWISQRYVTDGDMLRNHFDASMPGVSPGDLGLLLASVDACREKCWVQSDRLFDMLIRLGKHGQVVPTLKRLLLHGTFLHPLSAAATINKLAACDIPLAWTFYRTFQQHAHWVPRPTYPRTKWEQQRDSILDGCAPLVIGMVNNSSLNLKIILKALGVGTMKSGRSVERQELVHPLQPQKVKLLRKLALAIAHCERRNPRVLIRNIQHINEYLRHHDVSPHPSITRAFTHACITKNILHKSWIGTERARWVLSKVKTVEGAAVADALATTVSCWQQQMLAENEKDDLRNRAPLDLRGRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RW37</accession>
    <name>A0A3D8RW37_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_05873</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RW37"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="37"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW78021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="448" mass="49659" checksum="1DD3AE5D1F3A41BD" modified="2019-01-16" version="1">MDSIWDRIRRLFSEPTKSEAGVSPDQNLNDKEAPLSIAIIGSGIGGLALAIGLLKQNVPFTLYESAAAFSAIGAGVGLGPNALRAMDMIEPRLRKLYDGISTGNSSPEKINDMFDGMMAEPGLGENSGWHGAPVTSPHFTRTSAHRMGLLDIMKSLIPAEMVKFSKRVVDVEQKGEKVFVTFADGEIIQVDTVIGCDGIKGRTRKAVLGSRYPDEVHAKYSGVYVYRCLLPMEEAQKLLGPLAGDAKMFMDNGRNLAMYPVEQLKTVNVVWFILDKGTWNSEENTEEVSREYMLSDVQGSDPRLIKFLGFAKPLKWALFHHKYTSTYYSSQICLLGDNAHATTPHQAAGAGQAIEDALVLSSILPLVKKVSQLPKAFKIYEDIRRPRAQKVVDTSEETGRIYMFQDPTIGSDMRKLMVTANERLPWIWLHDLDKDVRTAKERFLAEAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RW40</accession>
    <name>A0A3D8RW40_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Translation initiation factor IF-2, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_06070</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RW40"/>
    <dbReference type="OrthoDB" id="361630at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03702">
        <property type="entry name" value="IF2_mtIF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03692">
        <property type="entry name" value="mtIF2_IVc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000007">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000008">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000001">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000019">
        <property type="entry name" value="Translation initiation factor IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00100_B">
        <property type="entry name" value="IF_2_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053905">
        <property type="entry name" value="EF-G-like_DII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044145">
        <property type="entry name" value="IF2_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006847">
        <property type="entry name" value="IF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000178">
        <property type="entry name" value="TF_IF2_bacterial-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF20">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22042">
        <property type="entry name" value="EF-G_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04760">
        <property type="entry name" value="IF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01176">
        <property type="entry name" value="IF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tr-type G" evidence="12">
        <location>
            <begin position="544"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="38"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="142"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="214"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="295"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="526"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="840"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="39"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="171"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="312"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="341"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="371"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="404"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW78218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1077" mass="117899" checksum="9985AC373B6491EE" modified="2019-01-16" version="1">MRSRGLLKEPCGQTLCTLCARQLNASRQVSHVQRRYLQYSRSKSNQSTTGPAPQNDEQSQQRGPVSGGGFGPVAGASWGGAFGGIGSPSAGAGRSWSGSNTTLSPQSSGYDGSAVQVDNLLPHEQKARDLLSQREEAKSARIVTIHAGSGPASTRAGRPIISSTPSPAELEIDKRRRQGTDEGVIRASRPNPRARPDIRRIIPNEIVRHEPVELQTSSPLRRGRDSNNQESGWTGLRRIGSRAPSGTGAAVDGFAEARLKREQEATSRRYIPLGHRAPFVQRNSDERFGNNQSATLVAKDASPPNPGFTIRRSGTTSRPVANAIESNSVKATNPAMDPSLAQAQSQSHSKVTYSPMLPPEPPQTSLSDWQRSSRDVSKDTKTVDNEGKEEAASYTRQRQPRASSRFEVDSMPKGKAKDKAKRRQRFLENHEEPDEDTLSRQRRELKEQRKREKAAKKALDPVPVLLPEFISVSNLAIVLKVRFEDFVAKVEELGFEDMSHDHILNAETAGLIAQEYNFEPIIDRNESEDLKPRPPPDNPSSLPQRPPVVTIMGHVDHGKTTLLDWLRKSSVAATEHGGITQHIGAFSVPMPGGKLITFLDTPGHAAFLSMRQRGANVTDIVILVVAADDSVKPQTIEAINHAKAAKVPIIVAINKIDKEDSDIERVKQDLSRHGVEIEDYGGDTQVICVSGKTGQGMENLEEAAVTLSEILDMRAEQDGQAEGWVLEASIKPLGKTATVLVRRGTMRAGDFIVAGNTWARIRTLRNEAGTTVAHAGPGTPVQIDGWKDLPLAGDEVLQAPDESKAKSVVEYRLDRVERDKLAEDMEAVNEYRKEVEVTREKEREDARVAAESLTGHEALPLPEPEKSGGPKNVYFIVKGDVSGSVEAVIDSINGIGNGEVQPYILRSGVGQLSEFDIEHAAAAKGHVINFNTSVDENVVSLAKYANVSILDNNVIYRLVDDVKKKLSEYLPPKITQRVLGEAEIAQVFEITVKGRTTKAVAGCKVRNGVIGRNARVRVLRDGEKVFDGALASLKNQKKDVMEMRNGTECGIGFENWFDFQVGDKLQAYEEKEEKRYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWD7</accession>
    <name>A0A3D8RWD7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proline iminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_05973</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWD7"/>
    <dbReference type="OrthoDB" id="1898734at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002410">
        <property type="entry name" value="Peptidase_S33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF2">
        <property type="entry name" value="PROLYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00793">
        <property type="entry name" value="PROAMNOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="46"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW78121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="443" mass="49639" checksum="D8C993DC1425667D" modified="2019-01-16" version="1">MRFQVPLDYSNPSSGTLEIFARSASRHESPVVPASDEEASKKSQKPWLLYLQGGPGGACPPPQSMALTNVALDKGYQMLYMDQRGTGLSTPISASTLALRGDAQQQADYLKLFRADSIVQDAEAIRKTLTHDYPPELKKWSIFGQSFGGFCALTYLSKSFQGIREVFMTGGLAPIAIQHADEVYKATYKLVMDRNKSYYSKYPEDVENVQKLAFYIKSKGGIPLPSGGTLTVRYFMTLGKVFGAHGGIDSVHEHVYRMTSDLEQFQFLTRPTLSALENALTFDNGVLYAVLHEAIYCEGTASNWSADRVGKSLKEFQWLSSVPNSPADLSEQPLYWAGEMIFPFMFETSTELAQLRPAAELIAQYSNWPALYDEWQLARNEVPVYAATYFNDMYVDFGLAQLTASKVKGIKQFITNSMYHDALRSRNEEVMHQLFAMRDDSID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWN2</accession>
    <name>A0A3D8RWN2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_06309</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWN2"/>
    <dbReference type="OrthoDB" id="3649348at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW78457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="170" mass="18129" checksum="322BA6DEF0C687EB" modified="2019-01-16" version="1">MSSQSPIPVILCGQQAEIARSVQAALLPEYEELTTNQTSPPSTVIHVILSASVGTTQIPGLLSDAHHPGTPPDAAQVGTQNYSQKPQAVICGAAYDEKIVDGMRRACDAPGRSPSEGVPWLMADLNVKRPPIEEVGRQAYGEYMTQRVKTCLGKLVGEDKLGKGDCVVLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWS8</accession>
    <name>A0A3D8RWS8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Methyltransferase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_06359</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWS8"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW78507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="260" mass="29823" checksum="531D3E96FA779D2A" modified="2019-01-16" version="1">MTNNNDDLAYGDEDVHSVWSESITSSVVDYEYQNGRRYCGYRRGAYPLPNDEEEQDRLDLLHHIFRLALHSSRVSAPIGPIPQRVLDVGTGTGIWAMDFSDELPSAQVIGTAISPIQPSWVPPNTKFYIDDAESEWVYRPDEASTFTCYTHVKPGGWVEFQEPEAWFRSDDNTKDRVPFVNQWQTLRNDAAKQFGKEIDLAPTHKQRMIDAGFVDVREQLVKIPVGLWTKDPHFKELGWYQLLHTTLSIEPYALAFICNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RXD8</accession>
    <name>A0A3D8RXD8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Pyruvate carboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_06356</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RXD8"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45007">
        <property type="entry name" value="CARBOXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G07570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45007:SF1">
        <property type="entry name" value="CARBOXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G07570)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50968">
        <property type="entry name" value="BIOTINYL_LIPOYL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0092">Biotin</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="9">
        <location>
            <begin position="10"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="8">
        <location>
            <begin position="125"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="Lipoyl-binding" evidence="7">
        <location>
            <begin position="577"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW78504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="661" mass="71604" checksum="A428BFE40D5D48AB" modified="2019-01-16" version="1">MAAHTSSQRPIKRLLIANRGEIATRILNTARELSLATYTLYTANDSTHTVHSTHSIQVSSAGSYLNIDEIVSIVQEYHIDAVHPGYGFLSESPEFAAQIWDKAGAVVIGPGAEILSQTGDKLQARVLAENCSVPVLPALKSPTSSVEDLAAFADEVGYPIVVKAVDGGGGRGIRIVKRKEDLEALSKRALQESPSGMAFAEKAAIDGYRHVEVQIIGDGRGGVRHLWERECSIQRRFQKVVEFAPSSIQDRGLVGEVIEAAVRMAKAVNYLSLGTFEFLVRSSPRSYYFLEVNPRLQVEHTVSESISHGLDLVKIQLLLAQGESLDSLIPSSLSDNPEQPPPLHSIQLRVTTEDVSNNWSLSVGKIISYRLPAGHGVRVETNLLPGCQAVIGSDFDSLLAKIIITTSTWQDTVAKARRALEDTYIEGVKTSLDGLHGIVNSKAFLHQTCDTQWLEANLPSVLESGKRLFSKASMGHVGFLGGQLSAEQANISAASSSSVLFRKGDAWSITLRPEDTVDPEVVLPPAHLLINKINRNEFPTALSASITYSSPRTEPQSYTLALQSTNSSASALASTSKHRRGFPSNPKHIVLPFSGKLMELLVDEGDIISKGHVVAVVRQMKMELEIRAERGGTVVWTYEGEEGDEVGEGILIAELEGGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S236</accession>
    <name>A0A3D8S236_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-phytase</fullName>
            <ecNumber evidence="2">3.1.3.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_05037</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.8" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S236"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016158">
        <property type="term" value="F:inositol hexakisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF23">
        <property type="entry name" value="3-PHYTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017753345" description="3-phytase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="418"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="444"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW80339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="611" mass="64760" checksum="D0497579659DC33A" modified="2019-01-16" version="1">MSTRSLLKIVASLAVATTASAATGDDLAPAYDINFPAGTSSTLEPLHYAGANSPYFPGPDVYDIPYEVPEGCTVQQASYIVRHGSRFPDSGSYNSWVAIQERIQAAAALPGFNATGSLSFIPTWQTVLTDTTLQMSQESMTGYKEAHDLGYQLRTRYPDFYKDGNDYMVWANQYAAPINESRVVQTAQAFLQGYLYIYADTYGSVVAINSTASADALGDSLSPSDMCPAFTNDAKNNVTDFDNTWVPDALTRINAMVTGNLTFTENDILFFPYMCGYESQITGRVSPWCGVFNDTELLNYAYSQDLSYYYGTGPGSSGPASKLFLPYLDEIITLLMEGPGQQGVGPDGPFTVPNLIMGFMNDNQIAQLTSAMGIFDSNKLPIDYYPGAHEYDISHFITMRGTVAFEVLNCAASAPKASSSATFSSSTTGASAPGSTVAVTGTQTASSNGTAPTATASSPTGTGSSGSATGIIGKSTGSSVTPTGTPYGFTSTGTPNTLITTTVTASDCAATTAAAKPKSGHQFKRRANANETYIRVIFNDAVYPIINCQDGPGNSCLLSEYAAYIHQENEAAGDFTSYCNVTAAGSEKSVVNGASFYTNTTLDFLTIVKSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2S3</accession>
    <name>A0A3D8S2S3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_05273</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tannase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2S3"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF16">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017496820" description="Carboxylic ester hydrolase" evidence="8">
        <location>
            <begin position="17"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW80575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="583" mass="63236" checksum="304474C8A5F20CCC" modified="2019-01-16" version="1">MRAVSQLLALAAPAAALTITDLCTTSYAQSALPAPGFYSGIIIDSSSVVATLGTNYSISGNDFFPDAVINYCNVSFAYTHDGRDDTVNVAYWVPDPSKFSNRFLSTGGGGLGINGGANSVSGGVSLGAVSGLTDGGFGSFNGQDDTTFLLANGTVNWENAYMFGYQAIHEMTVLGKEFTKNLFSINNGTKLWSYYHGCSEGGREGWSQLQRFNEFDGASVGAPAFRYAFQQIQHLYSNVVEQTLNYYPPPCELEAILNATMTACDPLDGLTDGVVSRTDLCKLQFDIESVLGTPYYCAASSGGGGFPGKAKRQMGSGATPVQNGTVSAKAIEVAKTILDGLHDNQGRRVYFSYQPTATWSDAATQYNSATGQWELSISGLGAEFVTRYLDLQNVSTLSTLDGVTYDTMKGWIYGLWQQYEDSLQTTWPDLTHLQEGGAKVIHMHGESDFSIPTASSVRYWESVRQIMFPGLSYNESSAQLQDFYRLYLVPGGSHCSPNSNEANGGWPQTSVNQLIDWVENGIAPDTLNSTIFYGANTGDTKPICLWPLRPLWTGNGTAMECVYDQASIDTWHYDIDAFKMPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S300</accession>
    <name>A0A3D8S300_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Radical SAM core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_05357</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="5">Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S300"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040085">
        <property type="entry name" value="MJ0674-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016431">
        <property type="entry name" value="Pyrv-formate_lyase-activ_prd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43075">
        <property type="entry name" value="FORMATE LYASE ACTIVATING ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43075:SF1">
        <property type="entry name" value="FORMATE LYASE ACTIVATING ENZYME, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G15630)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004869">
        <property type="entry name" value="PflX_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01099">
        <property type="entry name" value="Uncharacterised_Radical_SAM_Su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 5" id="KW-0408">Iron</keyword>
    <keyword evidence="4 5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="Radical SAM core" evidence="7">
        <location>
            <begin position="71"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="75"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR004869-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW80659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="331" mass="36952" checksum="25A23F7F194018A6" modified="2019-01-16" version="1">MLSSVEASKKRSAAYAHLRNCNLCPRLCGVNRYEKTGMCLIGAETVKVNVIAPHFGEEPCIQGHNGSGAVFFSGCNLRCVFCQNHDIAHQRNGQDLTPEELGEWYMKLQTVGRVHNINLITPEHVVPQVVLSILHARDLGLNIPIIYNTSAFDSLASIELMDGLVDIYLPDFKVWKDSTSKRLLKADNYTAVAMESVKAMHAQVGDLCFTPDGIAKKGLFVRHLVMPGKEDEGEEIMRWIASNVSRDAFINIMEQYHPDAHVGKPSRRHINDTVASEPGTEPMDQQKASKVRYEEINRHVTADEISTVRKAAESAGLWRFCDPPRHDGFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3U6</accession>
    <name>A0A3D8S3U6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_05634</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3U6"/>
    <dbReference type="OrthoDB" id="3862662at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="116"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="202"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="224"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW80936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="727" mass="80600" checksum="5238E8051965795D" modified="2019-01-16" version="1">MARPTLRVSSRTSENKDGACYTSQVQYRAPFQGCGDDVGEDAAAWKGRTGNSERPLSKPTPASWDMEAPRIRHILRLCRATRGQARIKVGQHMSVRSDSTGDAAAGGDGGDISKVVCSLCRQRKVKCDRQVPSCGFCNQVGNACRYVATPKKRGLRAGYVSSLENRLAKLERDVSELKSQPPRNSPLEVDEDKILISVEPQYLPTSRNEPATPSDGGSGREPTSPASQRSLNSTASEVGSLSKATLQGLCNAWFERYHPWFPILHKLSILDAVQHTSVPLSGSPLFIVHKAIVAVTLPHWCLSNPLTREQRQELSTKFRNEVIMQAIGNLSLQSLQAVLIITNLDYGAGKLSEFWNLVALCKRMGIQLGLRDLVTNDLNKPAPRMLSLPTTLIEQEERIRAYWMTEVLDSMSSLGAGWNLGLSRPENEAWFPCDEVVWAYPENATAFSSFGDSEVSSAFSLYLNLVTHQLYPVHVFLQQSFDTTSAVDRLRWQENCTAVDEVLSKWRYSAETVQTLGRSNAASDSTLVMTTVTFDTAIIALYQRLALPPMGLGEVHGPWYHAIQRCLSACDDMSATIRAVSDADLENISPFMIFCIFIAARFYLVHAKILSVEVPRSLDLLIYGLKTCGQRWFFARRLERVLSTAISEKKVPLAMSSLPAQFYDLQYSSLDIDEALRKWSLGVDGSTYEVPTHAPAETSPGQWDDMQDILDARAPNLHTGTHDGMIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S419</accession>
    <name>A0A3D8S419_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BP5796_05539</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S419"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21691">
        <property type="entry name" value="GH2-like_DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05684">
        <property type="entry name" value="S1_DHX8_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000061">
        <property type="entry name" value="ATP-dependent RNA helicase DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000101">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000191">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049588">
        <property type="entry name" value="DHX8_GH2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049621">
        <property type="entry name" value="S1_DHX8_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF85">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1 motif" evidence="12">
        <location>
            <begin position="233"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="547"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="728"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="140"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="448"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDW80841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1201" mass="134913" checksum="E93F581CCB59322C" modified="2019-01-16" version="1">MDDLESLELLSLVSKVTSELQNHLGISDKTLAEFVIAQHSQCSSLDEFQKKLEAMGADFPQSLIESIDRLVLTMHPKFKGSKGRNGDHAANSSRKAEEKEKIFKGLALPDKEIPWQDDPVDNTNGTDAIDDTLALLENLGEKARTEQPARSSRKRSRSPDVENYDRGRNRRDKYRSRSRSREDHRHRRRGGPDDEDEFGRSRTGHKSSRRRRDDDEQFRRPPVPEIDDKAVLFKVYDGHVTGVKDFGAFVNIHGVKGKVDGLVHISAMMEGSRVNHPSDLVERGQPVKVKVIKIEGSRIGLSMKDVDQETGRDLAPQARIQSGANSERLGGGKDEYGLIDDKVIVSEGDMSRNSRRTKKRMTSPERWEIRQLIASGVVKASDYPDLEEDYNATLNGEGEMELEEDVDIEIREEEPPFLAGQTKQSLELSPIRVVKAPDGSMNRAAMAGTTLSKDRRELRQQEAQDKAAEEDSKVDLSAQWQDPMANPDAKKFASDLRTAKPPQTNEVVPEWKRATQSKEQSLGRRTDMTIKQQRESLPVYRFRSELIKAVHANQLLIVVGDTGSGKTTQLTQYLAEAGFANDGLIGCTQPRRVAAMSVAKRVAEEVGCELGQEVGYTIRFEDCTSPATKIQYMTDGMLQRQILMDPDLKRYSVIMLDEAHERTIATDVLFALLKKTLKRRPDLKVIVTSATLDADKFSAYFNECPIFSIPGRTFPVEVMYSREPESDYLDAALVTVMQIHLTEPPGDILLFLTGQEEIDTSCEILFERMKALGPSVPELIILPVYSALPSEMQSRIFDPAPPGSRKVVIATNIAETSITIDHIYYVIDPGFVKQNAYDPKLGMDSLVVTPISQAQAKQRAGRAGRTGPGKCFRLYTEAAFQSEMLPTSIPEIQRQNLSTTILMLKAMGINDLLHFDFMDPPPTNTMLTALEELYALSALDDEGLLTRLGRKMADFPMEPALAKVLIAAVDLGCSDEILSIVAMLSMPTVFYRPKEKQTQADQKKAKFHDPHGDHLTLLNVYNGWKQNKFANPWCFENFIQARSMRRAKDVRDQLVKIMERYKHPIVSCGRNTQKVRQALCGGFFRNSARKDPQEGYKTLIEGTPVYLHPSSALFGKQAEWVIYHTLVLTSKEYMHCTTSIEPKWLVEAAPTFFKVAPTDKLSKRKKAERIQPLYNKFAAEDDWRLSAQKRQGRGGGGGTWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S9A4</accession>
    <name>A0A3D8S9A4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_04428</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW82937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S9A4"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW82937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="108" mass="12857" checksum="36BFA406A4C58BA7" modified="2019-01-16" version="1">MSQLPKNMIRQSMFYNREYYYPHRDESVLVPHLEHCIDNLRESLMCEGDMTFYPMLWAENMGRVIPDFEVVHTCRDYSALKEWADNRDAATEGVWQKSAARLHATMEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S9C5</accession>
    <name>A0A3D8S9C5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Gly-Xaa carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_04374</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW82883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S9C5"/>
    <dbReference type="OrthoDB" id="3064516at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05674">
        <property type="entry name" value="M20_yscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000027">
        <property type="entry name" value="N-fatty-acyl-amino acid synthase/hydrolase PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001261">
        <property type="entry name" value="ArgE/DapE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017141">
        <property type="entry name" value="Pept_M20_carboxypep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047177">
        <property type="entry name" value="Pept_M20A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011650">
        <property type="entry name" value="Peptidase_M20_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45962:SF1">
        <property type="entry name" value="N-FATTY-ACYL-AMINO ACID SYNTHASE_HYDROLASE PM20D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07687">
        <property type="entry name" value="M20_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037217">
        <property type="entry name" value="Carboxypeptidase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00758">
        <property type="entry name" value="ARGE_DAPE_CPG2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M20 dimerisation" evidence="8">
        <location>
            <begin position="294"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="177"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="550"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037217-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW82883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="580" mass="63869" checksum="BD230CF602E1CB80" modified="2019-01-16" version="1">MKGTQGFSFDAAHSRSSPQALQITAASKKLFFVLPSLAILYILQRVAWRSSVSSVLKSSVISLPTCPIQSVIHPTNRADITSRNVEALFSSLSFKEQIAQQLSGAVQIPTICYDEMGAIGQDTRWEIFYELGRYLQETFPLVYNKLDVATVNEHGLLFTWQGSDTSLKPLLLMAHQDVVPVPNMTLGRWTYPPFSGHYDGTYVWGRGSEDDKSNLIAILAAFAALLEAGFEPSRTVLFSVGFDEEGGFPESYGAKALAARILELYGHGGIELIFDEGIAGIESHFGTEFAMPATAEKGYVDVTITVNTRGGHSSTPPDHTAIGYLADVIKAVESNPFPSSLTEDNPTATYLSCVADYGKAVPPLIRDSIRDPRRQREVIQYLEERPDSRALIRTSVAVDVVAGGSKANNLPESAYILVNHRIAIDHSVATVKTHYTDIISPIAARLNFSLCGFGHGDHGCNEREGSIYLSARDELEPSLVTKSDSSQFSWLTGTLRGVFGDEVVVAPVLLSGTILSRGNTDTQFYWNLSSHIYRMSPWRASLDSRGTNMHTVDERMPILGLLEMIHFYHEFLRVVDEMRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S9T6</accession>
    <name>A0A3D8S9T6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04511</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S9T6"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW83020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="215" mass="23481" checksum="1820C2D2787AC819" modified="2019-01-16" version="1">MRSSRRLPRWPAKVGPGAQRLTARPERKLVVIFLAKLLELNACPRPPNPQGITAVEIHGDQAHGWLTQTANGRVLSCATIVKVGMASGPEKVRGKEWKHHWAAPEGGSWSTGDSVNLERGEAQHRAGRRARGQLMRQREKVEDEPRRAVERHALLVCFSASTARRATPHAMERALGGSFACPIHHSQDSTAHPKQLGRCSGLWANVTGDVGVSLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S9U4</accession>
    <name>A0A3D8S9U4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3beta-hydroxysteroid 3-dehydrogenase</fullName>
            <ecNumber evidence="2">1.1.1.270</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_04534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 5/6.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.270" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S9U4"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000253">
        <property type="term" value="F:3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051593">
        <property type="entry name" value="Ergosterol_Biosynth_ERG27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647">
        <property type="entry name" value="DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43647:SF4">
        <property type="entry name" value="KETOREDUCTASE (KR) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023621"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW83043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="339" mass="36823" checksum="DEA57766DBA999D2" modified="2019-01-16" version="1">MAGITKVKETTSQGTVLITGANGSLGLSLVQQLLEQYPSYSAILTVRDISDRDPNTEALRKLLSRFPAANATIEVLDLASLSNVRAFAEDVASRVSTGKIPPIAAIVCNAFAWSLVGMKHSSDDYELGFQVSHLSHFILVLKLLDAMNKSTGRIVLLGSVVHDGAEKFGAKFPDDLEKVIKPPSDKPGEEFAQGFQRYANSKLANVMFMLTLNKRLAKDPSLKGITAVAVNPGDMPTSRAFQHVPFAFRMVLKIAACLLPLFQYFTSLTTTKSAAINLMAMSVGPDASGSRGYFEGQKPVQSSKDSQDKGLRERVWKACEKWCGLKQSETVLNIGEGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SH08</accession>
    <name>A0A3D8SH08_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_03759</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SH08"/>
    <dbReference type="OrthoDB" id="4216928at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="7"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW85434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="323" mass="35847" checksum="7DD4562C2973436C" modified="2019-01-16" version="1">MTTLRKACRNCTTSKRKCVVQLPKCTRCAQKGLGCTYDLEPLKAPTSPPLNEDASGYCIMKTFKSPASSIDPAICRSGNEDSLEFVRLGYLSVPGLVRAGKPAVFVHPKLQLHNTHNYFAALGEAGKGGVSYESFKSLIEINVKIVPVKEALTALQALLVYLATFLFSSSQVEQLRAENSLSVLSEWTQTLLESAQARMPQHQSPWQEWLFGESVRRTIIMSNMLSLLLYSFRYGYCSRWLFLESLPFDRRAGLWMAESPQAWIAAARVRTGEEVGERLNSLHEFAESCDGSDPDFGGDMFLALLTLGHNGAKTNHERRPGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHB8</accession>
    <name>A0A3D8SHB8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Arf-GAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_03896</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHB8"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08839">
        <property type="entry name" value="ArfGap_SMAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000010">
        <property type="entry name" value="Stromal membrane-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044732">
        <property type="entry name" value="ArfGAP_SMAP1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF1">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="3">
        <location>
            <begin position="17"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="427"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="510"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="229"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="309"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="365"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="430"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW85571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="559" mass="57902" checksum="B2B4BC3B86D380F9" modified="2019-01-16" version="1">MSRRAPDPAAERAARNTQTLKSLVKLEGNKTCADCKRNKHPRWASWNLGIFICIRCSGIHRGMGTHISRVKSVDLDAWTDEQLQSVLKWGNARANKYWEAKLAPGHVPSEGKIENFIRTKYESKRWVMEGPIPDPSTLDVEGDDDIPLNLVKEKQNIERSASLKAAGPAGASQIRRAPQQDLFGDDSAPPRPSTTTPVARVAPKAEPAPPKQSKPADSLLGLDFFGTDAPAPARPASAAPTPGAQSRPDLKQSILSLYASAPRPQPQQQISHASSGSFGGMQSPTLTQQPSSQSGFGKMNDAFGGLSFSNASSPPAQPKPSAFSSLGNLSSPRSSVSSPPLSGGSFFDAKPAANITPTPPQPTRGFSSSSGFGDFDAAPGISPMVTTTASSGLGDLFDFTTPAAAAPAAPKQTIASPTIQQSSVFNLSSPQAPQQAAPQPAAVESAGWGSNSDAWGSNNAWSTPAQKSPVNQPLPPAQASAGDFGWGSTSGSLANQSIVPGGGGGFNAAGAAPKVSADEDFGGWSSAAPVTPAANASSTTKPVATGFATNDDLFSNVWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHD0</accession>
    <name>A0A3D8SHD0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ATP citrate synthase</fullName>
            <ecNumber evidence="2">2.3.3.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">ATP-citrate (pro-S-)-lyase 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="17">Citrate cleavage enzyme subunit 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BP5796_04080</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the formation of cytosolic acetyl-CoA, which is mainly used for the biosynthesis of fatty acids and sterols.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>oxaloacetate + acetyl-CoA + ADP + phosphate = citrate + ATP + CoA</text>
            <dbReference type="Rhea" id="RHEA:21160"/>
            <dbReference type="ChEBI" id="CHEBI:16452"/>
            <dbReference type="ChEBI" id="CHEBI:16947"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.3.3.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="15">Composed of two subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the succinate/malate CoA ligase alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.3.8" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHD0"/>
    <dbReference type="OrthoDB" id="3261737at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003878">
        <property type="term" value="F:ATP citrate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06100">
        <property type="entry name" value="CCL_ACL-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.261:FF:000003">
        <property type="entry name" value="ATP-citrate synthase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.230.10:FF:000005">
        <property type="entry name" value="ATP-citrate synthase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000024">
        <property type="entry name" value="Probable ATP-citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.580.10">
        <property type="entry name" value="Citrate Synthase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.230.10">
        <property type="entry name" value="Cytochrome P450-Terp, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.261">
        <property type="entry name" value="Succinyl-CoA synthetase domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017440">
        <property type="entry name" value="Cit_synth/succinyl-CoA_lig_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016142">
        <property type="entry name" value="Citrate_synth-like_lrg_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016143">
        <property type="entry name" value="Citrate_synth-like_sm_a-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002020">
        <property type="entry name" value="Citrate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036969">
        <property type="entry name" value="Citrate_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033847">
        <property type="entry name" value="Citrt_syn/SCS-alpha_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003781">
        <property type="entry name" value="CoA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017866">
        <property type="entry name" value="Succ-CoA_synthase_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005811">
        <property type="entry name" value="SUCC_ACL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016102">
        <property type="entry name" value="Succinyl-CoA_synth-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23118:SF42">
        <property type="entry name" value="ATP-CITRATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00285">
        <property type="entry name" value="Citrate_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02629">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00549">
        <property type="entry name" value="Ligase_CoA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00881">
        <property type="entry name" value="CoA_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48256">
        <property type="entry name" value="Citrate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01216">
        <property type="entry name" value="SUCCINYL_COA_LIG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00399">
        <property type="entry name" value="SUCCINYL_COA_LIG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01217">
        <property type="entry name" value="SUCCINYL_COA_LIG_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CoA-binding" evidence="19">
        <location>
            <begin position="45"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00054002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00060724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00062455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00076189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00083544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="SMART" id="SM00881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RDW85755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="664" mass="72065" checksum="A402E5BB82712F9F" modified="2019-01-16" version="1">MPSATNGTNGASTNGSAGATVSANDNIRRFAAPSRPLSPRAEHTLFHDKTRCFVYGLQPRAVQGMLDFDFICKRKTPSVAGIIYTFGGQFVSKMYWGTSETLLPVYQDVEKAMAKHSDVDTVVNFASSRSVYSSTMELMEYPQIKSIAIIAEGVPERRAREILHVAKKKGITIIGPATVGGIKPGAFKIGNTGGMMDNIVASKLYRKGSVGYVSKSGGMSNELNNIIANTTDGVYEGVAIGGDRYPGTTFIDHMLRYEADPECKILVLLGEVGGVEEYRVIEAVKNGIIKKPIVAWAIGTCASMFKTEVQFGHAGSLANSQLETAASKNAAMKKAGFFVPDTFEDMPALLGTVYQDAVKAGTIKPQPEPIVPKIPIDYAWAQELGLIRKPAAFISTISDDRGQELLYAGMPISDVFREEIGIGGVMSLLWFRRRLPDYASKFLEMVLMLTADHGPAVSGAMNTIITTRAGKDLISALVSGLLTIGSRFGGALDGAAAEFTNAFDKGLSPRDFVDTMRKQNKLIPGIGHKVKSRNNPDLRVELVKEFVKKRFPSCKMLDYALAVESVTTSKKDNLILNVDGAVAVCFVDLMRNCGAFSPEEAEDYMKMGVLNGLFVLGRSIGLIAHYLDQKRLRTGLYRHPWDDITYLLPTLGQGGAEGRVEVQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHL4</accession>
    <name>A0A3D8SHL4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative phosphate transport protein MIR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_04162</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHL4"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000024">
        <property type="entry name" value="MIR1p Mitochondrial phosphate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF12">
        <property type="entry name" value="MITOCHONDRIAL PHOSPHATE CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="28"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="126"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="224"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW85837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="320" mass="33539" checksum="81106862A2E4EA3F" modified="2019-01-16" version="1">MTSTGSVKVDSVVQTLKAETPEKLSGLQLYSRFALAGAICCSVTHGGLTPVDVVKTRIQLDPVTYNKGLIGGFRQVIAKEGAGALLTGFGPTAAGYFLQGAFKFGGYELFKQQAINILGYESASNNRTAVYLASSALAEFFADIALCPLEATRIRLVSEPTYANGLVGGFSKMLKNEGAGAFYAGFGPILFKQVPYTMAKFVVYEKVAEFVYTKVDKKTASDGLQTTINLGSGLIAGFAAALVSQPADTMLSKINKTKGLPGEGTTSRLIKIAKELGLKGSYTGIGARLFMVGTLTAGQFAIYGDVKKALGAVGGVEIAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SIA6</accession>
    <name>A0A3D8SIA6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HpcH/HpaI aldolase/citrate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_04236</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HpcH/HpaI aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SIA6"/>
    <dbReference type="OrthoDB" id="1621678at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005000">
        <property type="entry name" value="Aldolase/citrate-lyase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050251">
        <property type="entry name" value="HpcH-HpaI_aldolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502">
        <property type="entry name" value="2-KETO-3-DEOXY-L-RHAMNONATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30502:SF0">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03328">
        <property type="entry name" value="HpcH_HpaI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HpcH/HpaI aldolase/citrate lyase" evidence="4">
        <location>
            <begin position="39"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW85911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="276" mass="29542" checksum="9A80FA5904D8C5CA" modified="2019-01-16" version="1">MSTAPSSTEGKTPLRAALERAKAGGAPCVGQWMEFPGYTLAKTIAGLGFDWVLVDCEHGNIADNEMYLAIGAIASSGVSPIVRIPADEPWMMKRALDAGAHGIMIPMCESKEQAAKIVNAMKYPSDRWPQGFRGSGAMFAPANFNQNGAQYQRTANDNTLIIVQIETRKAVENVEEIASTDGVDMLFIGPNDLAASLGYFPFDHAKIEEVQVATARTLKACKDAGKYAGHFALSAEIAAQRSKQGFEFMNCGADIVAVTAWMAGEKAKMEALLKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SLX0</accession>
    <name>A0A3D8SLX0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">chitinase</fullName>
            <ecNumber evidence="2">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BP5796_02994</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the glycosyl hydrolase 18 family. Chitinase class III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SLX0"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02877">
        <property type="entry name" value="GH18_hevamine_XipI_class_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000145">
        <property type="entry name" value="Class III chitinase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000254">
        <property type="entry name" value="CBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035971">
        <property type="entry name" value="CBD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045321">
        <property type="entry name" value="Cts1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00734">
        <property type="entry name" value="CBM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00236">
        <property type="entry name" value="fCBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57180">
        <property type="entry name" value="Cellulose-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00562">
        <property type="entry name" value="CBM1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51164">
        <property type="entry name" value="CBM1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="3" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="8 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 11 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017824644" description="chitinase" evidence="13">
        <location>
            <begin position="24"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="15">
        <location>
            <begin position="31"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="14">
        <location>
            <begin position="402"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="CBM1" evidence="14">
        <location>
            <begin position="448"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="345"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDW87300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="484" mass="50004" checksum="13C7BDD7BC002D5E" modified="2019-01-16" version="1">MIFSVNTLVLSLHVLATIPAALAGFSTSSSSNVAVYYGQNSYGAGSGPLAQQRLSAYCSNTNFNIIPLAFLLSITQPTINFANAGNNCTAIADSTLLSCPQLAADISTCQNVYGKTILLSVGGATYTEGGFSSAAAATAAANNIWAIFGPVKSGSTVARPFGTSVIDGFDFDFESTVSNMVPFAKQLRSLMDAVTTAGGKRYYLTAAPQCPYPDAADKDMLAGAVYFDAIWVQFYNNYCGLQSYTPGTTVQNNFNFATWQNWAKTVSLNPNVKVFLGVPASSTAAGSGYLSAAALAPIIKYCKTFSSFGGVMMWDMSQAFANSGFLSGVAAALGTSAASISTTAKAASTSKPSTTPKPTTTSKSSSTTLKVTTSAKTATSSKASVTPKASVSIGVTASGTAGTVAEWNQCGGQDYSGNTQCSSGLTCVPYSVWYSQCEKVSTNANTSAGLAAWMQCGGQGYTGPTTCQVGLTCVTYGVWYSQCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SM56</accession>
    <name>A0A3D8SM56_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6924 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02958</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SM56"/>
    <dbReference type="OrthoDB" id="2884623at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053832">
        <property type="entry name" value="DUF6924"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21962">
        <property type="entry name" value="DUF6924"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6924" evidence="1">
        <location>
            <begin position="67"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF21962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW87264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="205" mass="23051" checksum="B9124B236DCE00C3" modified="2019-01-16" version="1">MADNIALFLTASEVSAKAFNRVLLLLQDLEYTEWETDTPWCVMTTDSVDQACVPTFPHLTASPTPNAFTGKSLQDINSFMRRNNDALNKPVDVLTDVWVVIDARGMQEGNCIVCEQDYDGETSEMMDSFRGVRLPFEHAWDICANLSISNMDLEAWVDEDAGPQEDGVYKWCGPFPGGKGNVEDPKLEEKRNAVLEKWKKDGYID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMR2</accession>
    <name>A0A3D8SMR2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Luciferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03266</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SMR2"/>
    <dbReference type="OrthoDB" id="5561043at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF41">
        <property type="entry name" value="XENOBIOTIC COMPOUND MONOOXYGENASE, DSZA FAMILY (AFU_ORTHOLOGUE AFUA_3G15040)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW87572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="190" mass="21359" checksum="EE282798881921EE" modified="2019-01-16" version="1">MAAVTKNLLFGVTASTTYDQRYALARRFSTVDHLSGDRVAWNIMTSYLDSAARNFGLDTQVEHDERYRIADENLDVVYNLWEGSWRDDAVVKDKESGQYADPERIRQIHHKGKYITVPGAHICEPSPQRTPYLFQAGTVFGAKHAEAIFVSAQLPELVSSASREHRLFYSDAAGGGYCIQAIKRAARDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMV5</accession>
    <name>A0A3D8SMV5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_03334</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SMV5"/>
    <dbReference type="OrthoDB" id="5296155at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW87640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="35681" checksum="2E5767F067554711" modified="2019-01-16" version="1">MFDHRAAPTAALPAIQEDASDLQAPPVPSRAPGRSKFSDDSNVTPPPAYDSKTPLYRNVSNQPGDEKLAALKNYKQVAKRGGWRRLALVLLLILLFIVALGVGLGIGLSRDKSKASSGDSSGGAVMQTPMVNTTFPAGSYNIETYLATANTNCTSNSATWRCYPYMTYPQSHTESAANFTWIIDYVVGNDSYMISSTDNIFSIVFSNQSLELKDAGLATEHYSFQMATQKAVIPSAALTSENIAATCYFNQTIFNAMLYTKMAKTYSSTSRTGSTESKTFAPWPYAVRVEQIAQSGPRTPSCLDASGISLGDFSLSEAGDPCDCLYMNTGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SNC6</accession>
    <name>A0A3D8SNC6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 11">Dihydroorotate dehydrogenase (fumarate)</fullName>
            <ecNumber evidence="11">1.3.98.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Dihydroorotate oxidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_02982</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(S)-dihydroorotate + fumarate = orotate + succinate</text>
            <dbReference type="Rhea" id="RHEA:30059"/>
            <dbReference type="ChEBI" id="CHEBI:29806"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:30839"/>
            <dbReference type="ChEBI" id="CHEBI:30864"/>
            <dbReference type="EC" id="1.3.98.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 11">Pyrimidine metabolism; UMP biosynthesis via de novo pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 11">Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.98.1" evidence="11"/>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SNC6"/>
    <dbReference type="OrthoDB" id="14784at2759"/>
    <dbReference type="UniPathway" id="UPA00070"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990663">
        <property type="term" value="F:dihydroorotate dehydrogenase (fumarate) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044205">
        <property type="term" value="P:'de novo' UMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04741">
        <property type="entry name" value="DHOD_1A_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.26.10">
        <property type="entry name" value="Dihydroorotate Dehydrogenase A, chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050074">
        <property type="entry name" value="DHO_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033886">
        <property type="entry name" value="DHOD_1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023359">
        <property type="entry name" value="Dihydro_DH_chainA_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005720">
        <property type="entry name" value="Dihydroorotate_DH_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109:SF1">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (FUMARATE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48109">
        <property type="entry name" value="DIHYDROOROTATE DEHYDROGENASE (QUINONE), MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01180">
        <property type="entry name" value="DHO_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="8 11" id="KW-0288">FMN</keyword>
    <keyword evidence="10 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 11" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dihydroorotate dehydrogenase catalytic" evidence="12">
        <location>
            <begin position="88"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00021374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW87288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="351" mass="36269" checksum="2038D13134B64BBE" modified="2019-01-16" version="1">MSSTPGPIEAGSPESFAINPPLLNSSNPWATTLADLTALYACPLTGAVTTRTSLLQGFPHNAAQHQYTFFSGPGGAATARVGEDGRSEVKSGEGCSLNTLGYSPIVLDEYLAMVVEVAAQAASLLTERTTPKPFIVSVTGSAEEVAECYRRIAQVAAQNAQLTLFMEVNLSCPNILDKPPPAYDGAALAEYLRAIAAVKAGVHVGIKTPPYTYQGQYVTLMKTLEEATETCPISFITATNTLGSCLVLNEQNDPALSSASGSGIGGVAGEAIHPLSLGNVKTIRSMLDASPRADIKGISIIGIGGVSDGAGFRRMKSVGAAAVGVGTALGREGVAVFAKITSSLNERDLTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SNQ5</accession>
    <name>A0A3D8SNQ5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_03649</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SNQ5"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF92">
        <property type="entry name" value="AGL026WP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="166"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="367"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="56"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW87955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="520" mass="57381" checksum="80337B16816B9900" modified="2019-01-16" version="1">MAAKDGAPQHLDNVASAPSIEAPNDQEKIARVSGEDEIKGPEKFEPPELVRVMTPDRRASAERALVRKIDFRLLPMIILMYIMNYLDRNNIAAAKLAGLESDLNLTSTSVSILFVGYILMQVPSNILLNKIGKPALYLPTCMGIWGAISTATAACNSFGGLVAVRFMLGFVEAVYFPGCLYYLSCWYTRKELGLRYAFLYAGSLISGAFSGLIAAGITGNMDGLHGLRAWRWLFIIEGSITVGLAVSSIFILPNFPRTTKWLTEEEIQLATWRLVEDVGEDDWVDSEQQSLWHGAKLAFTDAKTYVLMVILFCIVSSASVTNFFPTVVQTLGFSNIITLVLTAPPYVLCVIVTMINAWHADRTGERYFHITIPLYITMAAFIIAVATTNTAARYFAMVIMVPSFYCSFILVLTWISNTLPRPPAKRAAALAGINAVSNTASIYASYMYPTSAAPRYVVAMSVNTATAFIAIIFCTILRFMLVRLNKKLDEGMAVDDIRDQEVDENGIPVVGTQRGFRYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SPM5</accession>
    <name>A0A3D8SPM5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_03442</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SPM5"/>
    <dbReference type="OrthoDB" id="3538998at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017568097" description="Extracellular membrane protein CFEM domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW87748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="378" mass="38549" checksum="4ECB1991AE3B95C6" modified="2019-01-16" version="1">MALLRKNMRASILCLVGGASMVLAGVQNYNPTGQGCLDPDGFLSCYAKQVDLVTSCATGCTASNVAGSQALKTCLTGCNGAQLAGNLGCWVQSCWNQLYSCENQLATISYFDGNDLIQNPNIFPWFPPPSDAVDGACSCNLGYVEGNKTIFLATPNFNQPCENVASRGNPAATAECACCEFSFPVSNILNICPTSDLSVLGMSAYIEHTQGLISASGDACAILNDGNQDSCLNTYGYRFRGDKVFNPLSLPSGIPGSDPLTNNPGNAFTDFGASAYTLNLFPGFSSTITPVPFNAKAGAATGTVSAAAVATGTESATQIATGTVARGSSAAGTATSSATGTAAATTSKSAAGGRNGVNEGLALAAVMLLASYNMFSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXS3</accession>
    <name>A0A3D8SXS3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phytanoyl-CoA dioxygenase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_02278</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PhyH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SXS3"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN CONTAINING 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20883:SF15">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW91113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="34354" checksum="2A93CC592B38415B" modified="2019-01-16" version="1">MTSFAKPYLRTTQVQNRIQLGQGTTFLPGPTSPSIEPLVKHVLEHGYVILPSIYTPHQVSHALSELDRLEKEQASGPASQGGRNAFEGFNTRRIYALPDKSRAFDCFPIHPTVLMLNDFFLQENYLLTSFHTVNIEPGATEQEIHTDDGLIALPRPRPLMGVGTMVALDDFTSTNGATTLIPGSHLWSDARVPTRSEMIPAIMPAGSMVYFLNTLWHSGGANTSSHTRRSLTIQYCQPWIRTFENMTVAMGWEDLDQVPKPLLKLMGFSTHDFMGYVDGRAPRTGVEMRKKRLIEWALQEREKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYB0</accession>
    <name>A0A3D8SYB0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">U3 small nucleolar RNA-associated protein 25</fullName>
            <shortName evidence="10">U3 snoRNA-associated protein 25</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_02487</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
            <location evidence="2 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the UTP25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYB0"/>
    <dbReference type="OrthoDB" id="10264378at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002356">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010678">
        <property type="entry name" value="UTP25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053939">
        <property type="entry name" value="UTP25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053940">
        <property type="entry name" value="UTP25_NTPase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933">
        <property type="entry name" value="ORF PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06862">
        <property type="entry name" value="Utp25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22916">
        <property type="entry name" value="UTP25_NTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7 10" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="UTP25 NTP hydrolase-like" evidence="13">
        <location>
            <begin position="259"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="domain" description="UTP25 C-terminal" evidence="12">
        <location>
            <begin position="527"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="24"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="54"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="114"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW91322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="721" mass="81743" checksum="160894AE165F4818" modified="2019-01-16" version="1">MAFHGSRGGSRGRGSISGAPRGRGGMRGRGRGGFRGRGKPIFDSARLAQKKEELEDDNSEGSSSEDEEAEEEAESADDSSDSDEELPPVKSYAALMQSLAADSAPQSKRRKLDHKPEPESLESLDERPVDGNDDADYVEEAEAGPESDIDDLLEDEDDEEDSSDPFEVHFANPNENILSQRLESIQQNQWTTTKAMVLKSGKATVAVPGKDTSKALNTLPTVSSPGALKLKQKLASIITKQRPSFDEIEAAVAPLFFGYQDVLYCERDTKNSEKLRRLVCLHAVNHVFKTRDKVIKNNARLAKEENNDELEFRDQGFTRPKVLMILPTRESCVRMVNMINSICEPDQQENRKRFDDSYTDKEERFSSEKTEDFRELFGGNDDDMFRLGLKFTRKTVKYFSQFYNSDIIFASPLGLRMAIGTAEDKKPDYDFLSSIEMVIVDQADALLMQNWEHVEFIFDHLNLQPKEAHGADFSRIRNWYLDNNAQYFRQTIALAAFNTPELNTQFFNRSKNWSGKVKINASYPGAIQELGLKVKQTFSRLESPSFATDPDARFTYFTTAIIPALTRHSKDSTGTVIFIPSYLDFVRVRNYFSTSPATSKLSFGSISDYTDVKDVSRARSHFLTGRHSVLLYTERAHHFWRYRIKGVRKVIMYGLPDNPIFYKEIVGGYLSRSVQEGQLEPGQGSVRVIFSKWDVMKLERVVGTERVGKMIREKGDTFDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYK6</accession>
    <name>A0A3D8SYK6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pleckstrin homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_02525</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2149224at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032065">
        <property type="term" value="P:maintenance of protein location in cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053005">
        <property type="entry name" value="Nuclear_Pos-Cytoskel_Interact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024774">
        <property type="entry name" value="PH_dom-Mcp5-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190:SF2">
        <property type="entry name" value="MIGRATION PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G07730)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28190">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12814">
        <property type="entry name" value="Mcp5_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pleckstrin homology" evidence="3">
        <location>
            <begin position="961"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="412"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="572"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="676"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="791"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1134"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1324"/>
            <end position="1388"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="153"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="492"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="676"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="702"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="817"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="855"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="903"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1139"/>
            <end position="1159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1160"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1188"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1226"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1250"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1268"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1329"/>
            <end position="1343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW91360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1388" mass="152513" checksum="6083FB4B3DB19777" modified="2019-01-16" version="1">MATEWETEDEFAAAAQASLPTPTDTPYRTPSRGSRRSSRQKSNSPGPSSSPPPLPTGEVARRGSRDIANDESISILDPRRFTPTLHANLVSEILALRRDQEEKTKVIESLEGALHDMRGEQEVLADELLTTAKESRKQQRQLALLEGGTSSALSELSRERDEAVDAIADFKKRLETAQKKIRSQEEDADRVQKLWTSDKDSWEDEKRKYERKVHVAETRLKTVLEEVAAFEANQQNTDFHPDNEAEQARESVLDNASVRTMSMTNSIRFSMLSGPNGYVAPKLNGISLADELDFDAESEDQTDAEGRESVMSKRHMRNLSRESFIAKAHRRNQSTESLMRAGSLTRGRFLANQAVLERLEGGIVEDDETAPASEVEYVDTGVQFSPPPSPKIAPVEASLPVVDKVDELQSSKAERQVVAESPHRELEVEANQRRKRVQPSSPLIIDAASQTVEDPLSPPRTPKSPTRAPPPPPTNEQPFVREMISSQTQTEPPSPKSPTRAPPPPPAPIPSIQLHPPNSRPASPRSDHAALLPQHSKDAGCQVSIRVAAPSRSVAMQTEEIRVDLRMNMLPRHLHPSAISSNPPSPEPQPQPLFNDDSHFTPLPGNLPPKSPLRRIRSQQSMADEIPSSPPLAPVHTRDAYPGNNDDGPLAAGKTNLRRPHRISSLFAGFDNASSDEAEEFADADMSDNDYRTALSAPRPQSVLSKFNQQRISPSPASVPENKALDEVVKPKMNGKASKQASHADYVFPDSQTQPQRVAMKPIKHFDKPLTLVSTSKPSIMARRALIQSGVAAHQGRQSPGLLDDALVEPPFPIPTRASSRQPPFSVSAPSDGNRSPTPRSNDPSSRGKGHHYRNSSSVRRARSANFPRGGSRYRRHGSRSPPPMSPSTEAPESPGLPPMPHNNVTISRYLQETSSNKYRSHRHQPSSTYTANTVNTSNTLNTTYTGSASAVTNPNNGPTSVVDAIAQTMIGEWMFKYIRRRKSFGVSEPTGGDESANGVRHKRWVWLAPYERAVMWSSKQPTSGSALLGKTGRKLTIQSVLDVKDDNHPPKGSPTCFNRSILILTPARALKFTAVSSERHYVWLTALSFLAHSSQTVPEVVPAPPPALKVPNFEVQPPQISRRRNGIRDSIRVAKGKTATNRAGPNSVNSSQYGGTDNSIREEETFYNDENKPRISESAEPPAVPRFLERGYDRGLDRVAVHGRKRSNTGGTRIPPPISFRGFSAPSTGTISHAPSSSTAGMSVGTTGSSDIYQSQPSSSVAPSGYTGMSVSGRSSIRTSDASARPGAVVNNFFDAVGTVRMEAFISPMAMSRFDDFPDEQDEMKMASAHRKRSRERRRRSRNRDSYYNNKGRLSEDWYGGSKTAGEEEYYPDQAGFGGRDDPFRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZA6</accession>
    <name>A0A3D8SZA6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_02263</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZA6"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF199">
        <property type="entry name" value="MFS EFFLUX TRANSPORTER INPD-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="58"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="174"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="277"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="443"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW91098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="544" mass="57434" checksum="B5FAAE7CEC9F7613" modified="2019-01-16" version="1">MASQSVEEHAIAITPVLTVTGSVDNPSSARQQGHEIETLEQGDSNDVEDINYPTGVKLWLTMISLCFMFLLTGLDLTIVAVAIPSLTDQFKTISDIGWYSASYFGKVYTVFPLKTVFIVGIIMFETGSLICTVAVNSPIFILGRAITGLGSSIFNAGIGKVLRHCFPLSNLAMANGLIGASQAIGLVSAPAVGGILIDAFSWRACFGINLPLGVLCIILTAYGFSDPIPNPDTALPLKEKLARLDFFGTILVVPSVACLMMALQWGGNKYGWGDTRIVVLLVASVILFAAFGYLQHRQGEVATIPLRVVKSRSIVAAMWYSACCNGVLAMTEYYISIYFQGVRGFTPSKSGLLGLPMIGGLAVSMGVAAAGTSKIGYYVPFMFATSVLAPVASGLLTTLDLDGSVVKPAVLLGFLGFAIGLGQQAPQLAVQAVLSISDVSIGGALIIFGAGMGSALWICASATLFNARLVTEIQSHSPLTNATALEEVGLSDIRGFIGEERLKAVLVGYNEAVVQTLYMPLALGIATVLGTGAMEWRSIKKKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZD1</accession>
    <name>A0A3D8SZD1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">asparaginase</fullName>
            <ecNumber evidence="5">3.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BP5796_02837</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-asparagine + H2O = L-aspartate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21016"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="EC" id="3.5.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the asparaginase 1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.1" evidence="5"/>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZD1"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004067">
        <property type="term" value="F:asparaginase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006530">
        <property type="term" value="P:L-asparagine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08964">
        <property type="entry name" value="L-asparaginase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1170:FF:000001">
        <property type="entry name" value="L-asparaginase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1170">
        <property type="entry name" value="L-asparaginase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004550">
        <property type="entry name" value="AsnASE_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036152">
        <property type="entry name" value="Asp/glu_Ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006034">
        <property type="entry name" value="Asparaginase/glutaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027475">
        <property type="entry name" value="Asparaginase/glutaminase_AS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040919">
        <property type="entry name" value="Asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050501">
        <property type="entry name" value="ICDH/IPMDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027473">
        <property type="entry name" value="L-asparaginase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027474">
        <property type="entry name" value="L-asparaginase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037152">
        <property type="entry name" value="L-asparaginase_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00520">
        <property type="entry name" value="asnASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43275">
        <property type="entry name" value="D-MALATE DEHYDROGENASE [DECARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43275:SF1">
        <property type="entry name" value="D-MALATE DEHYDROGENASE [DECARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00710">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17763">
        <property type="entry name" value="Asparaginase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001220">
        <property type="entry name" value="L-ASNase_gatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500176">
        <property type="entry name" value="L_ASNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00139">
        <property type="entry name" value="ASNGLNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00870">
        <property type="entry name" value="Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53774">
        <property type="entry name" value="Glutaminase/Asparaginase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00917">
        <property type="entry name" value="ASN_GLN_ASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51732">
        <property type="entry name" value="ASN_GLN_ASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="16">
        <location>
            <begin position="12"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="50"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="224"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="257"/>
            <end position="258"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010518"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001220-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDW91672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="486" mass="53243" checksum="EC6F0EE84A7F2375" modified="2019-01-16" version="1">MSSTSSPSRYYKIATIPGDGIGIELTQITLQVLKKCSRSHLPLGTDLADSQEHESVRERPPDPHPARNRSPLRNCQSRDLDWVIIRENSEGKYAGQGGITHAAPYSIATEVAVFTYPGIERVMRFAFETARSRPKKHLTLVTKSNAQRYGMVLWDLVFYDVAKEYPKADILMRAIENMTAAGIRTRTWVESATWTISIQSLIDAVPTITQITIVKGEQVANFRSTEVTSPILFDLCRRARTANESDDCAGVVITHGTDTLEETAFFLSLTVPWKKPIVFVGAMRPATAISADGPINLLQAVTLAASPTAMGRGPLVVLNDRISSGFYITKSSANALDTFKAPEQGHLGYFDNSQPKFFYSPASPIGLHYFDIKDMIDLSQVDIVYGYQGLNPHIITEYVRAGAKGLILATMGNGGWTIAGMEVVRQVIQEGVVVVHSHRSQDGAVSSSVDISISSGLLSPQKSRIMLQLALSSGYTLDQTKAIFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZR4</accession>
    <name>A0A3D8SZR4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_01178</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZR4"/>
    <dbReference type="OrthoDB" id="9997102at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF25">
        <property type="entry name" value="NMRA FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="8"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW91784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="317" mass="34399" checksum="84B356F815D86780" modified="2019-01-16" version="1">MSTSSISKPAILVTGATGQQGGATINALIEAGALKTHSLIAVTRNRESGAAKKLEARGVKLIQGDLSDCPLLFNKARAVLGGGKDVRVWGVFSVQPLVGDAEETQGKALVDAALANQVELFVYTSVDRGGEARSPSNPTNVPHFITKHNIEKYLLAQSKAHGDKMKWVILRPVAFMENMVPGFPGKLMGTAFRVILGKKPLQLIATRDIGWYAARALLRPDEFAGRSISLAGDELNFAQVNALFKSEVGQELPQTMSFLARLIMWLAKDLGAMIRWFAAEGYGADVKALREEHPDLQSFRDWLRESAWVAKSSVKDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T071</accession>
    <name>A0A3D8T071_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphoglycerate mutase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_01293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T071"/>
    <dbReference type="OrthoDB" id="3898179at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07040">
        <property type="entry name" value="HP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051710">
        <property type="entry name" value="Phosphatase_SH3-domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16469:SF27">
        <property type="entry name" value="UBIQUITIN-ASSOCIATED AND SH3 DOMAIN-CONTAINING BA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="117"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="265"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="479"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="581"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="649" mass="69986" checksum="3F47A3C30F3D0740" modified="2019-01-16" version="1">MGWPPAVVIVVRHGARLDAADKQWHLTSPTPYDPPLTYGGWTQSKALGARIASILRSRETDDDIPGTEGEEPRGDRRKRRHKVIIHTSPFLRCVQTSVAISAGLAQNPGHTHVKRASSSTRSSTPSQLHSSPKLPPAILTNSPRLAPIHEPSPSPTKKNGRDSPHPPNIKKSIVRVDAYLGEWLSPDYFELITPPPSSVMMVAGAKADLLRKEDYSSLLQVTTSNNQGFPGGWGSPVTLPKSTEDDHPFALSSLGEALKRRDRTSSLSSVGSSGSRQSGGKLTSSLNGPLTTDHGIYQPPIPNYSISSSDPIPPGYVAHARDACVDVDYQWDSMREPLNWGTGGEYGEEWSAMHKRFRKGLQQMVQWYSFNDDPAKLASKNPPTPPEEHEEADDEDTDLVIVLVTHGAGCNALIGALTAQPVLLDVGMSSLTMAVRRPPAAKSTPSSTPERKTRVNSQNISISDEYEVKLVANTEHLRSQSTTPTSSRTPSVSGLSAFRERFVPTGTSADTGLKFGQVRSATSAGLGSIRRNNSAAAATPRNYAPARQSSIGLWSSTQSEQDDEEDLGSSMVLSFGEGHPHSPTASAAPAAPTVPAEKSVESSAVVEIEREEVDDVAPLGLWGAPRPPGEAERIREIAPKRRWTVNERA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T094</accession>
    <name>A0A3D8T094_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_01391</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T094"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017599837" evidence="1">
        <location>
            <begin position="26"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="160" mass="17160" checksum="1044B669676A0013" modified="2019-01-16" version="1">MPPTKLSSFLMTLLALLNAFTCTTAQALIGSDGARRCAVPPPRSITTYLCKDPGYGECLMQRNLVSDACNPIAADLRVRLQFLRAAQLRGGCDEVVRGDDGVSVGKPRLGYGWGLEQQDCFMELYGEAAGLDVLMALSGKAFRVASGVWYLGEIPSSYGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1I9</accession>
    <name>A0A3D8T1I9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Short-chain dehydrogenase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_01836</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1I9"/>
    <dbReference type="OrthoDB" id="5296at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF12">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW92442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="266" mass="29398" checksum="1A46232F0C847262" modified="2019-01-16" version="1">MAWSLVCPANRGIGFHLTRHLLRETRIPVVATTRRDIEGVKKSILSDLPDVDSDRLTVMEIDVTDESTISKAASQAKSLFPPSTHHLRLAFCIPGILHPEKSPSQLNQEQILSTFAVNTVGPLLLTKHFSPFLPKKSLDLSEQTPDPTNLPQNHAVWLNMSARVGSTSDNALGGWYSYRASKAGVNSLTKTFDLFLKTRAADKAMAIAYHPGTVKTGLSEEFWGNVKKEKLFEPGLAVEKMLRVVNGVGIEGRGRCWDWKGEEILP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1S4</accession>
    <name>A0A3D8T1S4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="23">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="23">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">BP5796_01843</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="27 28">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15 23">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38567"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57262"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:38568"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>a 1,2-diacyl-sn-glycero-3-phosphocholine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphocholine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:38583"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="19">
            <dbReference type="Rhea" id="RHEA:38584"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66132"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="16">
            <dbReference type="Rhea" id="RHEA:66133"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(out) + ATP + H2O = a beta-D-glucosyl-(1&lt;-&gt;1')-N-acylsphing-4-enine(in) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66036"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:22801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:66037"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 22">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="23">Membrane</location>
            <topology evidence="23">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 23">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="23"/>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070867">
        <property type="term" value="C:mating projection tip membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990531">
        <property type="term" value="C:phospholipid-translocating ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140351">
        <property type="term" value="F:glycosylceramide flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090554">
        <property type="term" value="F:phosphatidylcholine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140346">
        <property type="term" value="F:phosphatidylserine flippase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090556">
        <property type="term" value="F:phosphatidylserine floppase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0099040">
        <property type="term" value="P:ceramide translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
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        <property type="term" value="P:establishment or maintenance of cell polarity"/>
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        <property type="project" value="UniProtKB-ARBA"/>
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    <dbReference type="CDD" id="cd02073">
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Phospholipid-transporting ATPase"/>
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        <property type="entry name" value="Phospholipid-transporting ATPase"/>
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        <property type="entry name" value="Phospholipid-transporting ATPase IC"/>
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        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
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    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
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        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
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        <property type="entry name" value="HAD-like_sf"/>
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        <property type="entry name" value="HAD_sf"/>
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    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
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        <property type="entry name" value="P-type_ATPase_N"/>
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        <property type="entry name" value="P_typ_ATPase"/>
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    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
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        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
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        <property type="entry name" value="ATPase-Plipid"/>
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    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF180">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE DNF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
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        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="PhoLip_ATPase_C"/>
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        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
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        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
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        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
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        <property type="entry name" value="ATPASE_E1_E2"/>
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    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 21 23" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="13" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="10 22 23" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 23" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 22" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 21 23" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 23" id="KW-1278">Translocase</keyword>
    <keyword evidence="6 23" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 23" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
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        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="23">
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            <begin position="170"/>
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    <feature type="transmembrane region" description="Helical" evidence="23">
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    <feature type="transmembrane region" description="Helical" evidence="23">
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            <begin position="1118"/>
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    <feature type="transmembrane region" description="Helical" evidence="23">
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        <location>
            <begin position="1200"/>
            <end position="1221"/>
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    <feature type="transmembrane region" description="Helical" evidence="23">
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            <begin position="1241"/>
            <end position="1259"/>
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    <feature type="transmembrane region" description="Helical" evidence="23">
        <location>
            <begin position="1266"/>
            <end position="1286"/>
        </location>
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        <location>
            <begin position="1306"/>
            <end position="1326"/>
        </location>
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        <location>
            <begin position="116"/>
            <end position="165"/>
        </location>
    </feature>
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            <begin position="1086"/>
            <end position="1335"/>
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            <begin position="1"/>
            <end position="94"/>
        </location>
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            <begin position="1360"/>
            <end position="1444"/>
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            <begin position="1"/>
            <end position="12"/>
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    </feature>
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            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
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            <begin position="75"/>
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    </feature>
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            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
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            <end position="281"/>
        </location>
    </feature>
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            <begin position="1362"/>
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        </location>
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            <begin position="1400"/>
            <end position="1417"/>
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            <begin position="1434"/>
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        </location>
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        <ligand>
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            <position position="616"/>
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        <ligand>
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            <dbReference type="ARBA" id="ARBA00052223"/>
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    </evidence>
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        <source>
            <dbReference type="RuleBase" id="RU362033"/>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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        <source>
            <dbReference type="Pfam" id="PF16209"/>
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        <source>
            <dbReference type="Pfam" id="PF16212"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="RDW92449.1"/>
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    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
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    </evidence>
    <sequence length="1492" mass="167848" checksum="0EBE1B1B0E482ACF" modified="2019-01-16" version="1">MTPQPPEEDPTTVEEGKPDNRRLRWATQRVKGKKGLQKRTSILGRLQHKRSQSEKKRESAGGESMATTELGGIQEENESIDENSNDNDGAEGPRTIFFNRAVPREFLDETGSLLQIYKRNKIRTAKYTPLSFIPKNIWYQFHNVANVYFLFLIILSIFSIFGASNPGLNAVPLIVIVFITAVKDAIEDYRRTILDNELNNSPVHRLVDWTNVNVNADNVGLWRRIKKATTRGMMAAIHSVKHSKNKDQDNTFTERGLDEPRPSHETANANRQSAYSNRTSFASAREDIQMTPVPSPLPRSEGNYLEIPGQSTTNNAPIVRNFGSLINPSVTPTGKARFHQDCWKNVQVGDFVRIYNDDQIPADIVVLSTSDPDGACYVETKNLDGETNLKVRHSLRSGREIKHARDCERTDFTIESEPPQPNLYQYSAVARWTQHEKDGSSGEDMAEPISINNMLLRGCNLRNTEWILGVVIFTGFDTKIMMNSGITPSKRSRITRELNWNVIYNFIFLFIMCLVSGLVEGVTWGQGNSSIDFFEFGSIGGTPALDGFITFWAAVILFQNMVPISLYISLEIVKTLQAFFIYSDVDMYYEKIDYPCTPKSWNISDDLGQIEYIFSDKTGTLTQNVMEFKKATINGVPYGEAYTEAQAGMQKRQGIDVEKEGAKAQAQIAAAREKMLVDIRELHDNPYLHDEDLTFIAPDFINDLAGESGEAQQAANYQFMLALALCHTVIAETTPGDPPRIEFKAQSPDEAALVATARDVGFTVLGNTSDGIRLNVLGEERSYTVLNTLEFNSTRKRMSAIIRMPDNTIVLFCKGADSIIYSRLKPGEQPELRKSTAEHLEMFAREGLRTLCIAQRILGEKEYQEWSKEHELAAAAVQDREDKLEAVSDAIERELTLLGGTAIEDRLQEGVPDTIALLAEAGIKLWVLTGDKVETAINIGFSCNLLNNDMELIVFKIEDDQLSSAEAELDKNLALFNKTGSDAELKAAMKNHEPPAPTHAIVIDGDSLKLVLDEQLRQKFLLLCKECKSVLCCRVSPAQKAAVVAMVKGGLDVMTLSIGDGANDVAMIQEADIGVGIAGEEGRQAVMSSDYAIGQFRFLQRLVLVHGRWSYRRLAETIANFFYKNIVWTFTIFWYQIFANFDMTYLYDYTYILLFNLAFTSLPIIFMGVLDQDVSDKVSLAVPQLYRRGIERKEWTNTKFWLYMLDGLYQSMICFFFAWFLFRVGIFVSGNGQDLADRERFGVYIGPAAVICINLYILLNSYRWDWLMGVLVIVSILLIFFWTGVYSAFSSSEYFYKAAPECFGQATFWAMLFLSVIASLLPRVCIKAIQKVYFPYDVDIVREQVRQGKFAYLDGPSDQIGDVSSKNSSRASSDIAKPSKHSHYPSVDEDRRPIYPPSVAPTTTTHNPRSQNGSDGTDFTRHRSSVEAPGRPSYDGHRPRPSYDRMRASMDRIRPSYEASNDFTSAALLTRLESSQSFGPVRSRRNDGIPES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T6S1</accession>
    <name>A0A3D8T6S1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_00008</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T6S1"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF512">
        <property type="entry name" value="SOBREMESA, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="276"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="359"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="483"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="510"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="572"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="18"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW94245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="618" mass="65957" checksum="93349E80C0471DB4" modified="2019-01-16" version="1">MSRNYSNTLQPHARDSLELASLASSSPGLRTSTSSSSSRSGISSSRKQSLEQEDPLDDRNPAASGRPGRPDRSFSINSTFDFAANLFPLSSSAGNGYAPIGAPISSSNGQSALGGGSLEKHKTLTYLNGLSLIVGLIIGSGIFSSPSQVNVNAGSPGASLIVWGIAGILAWTGAASYAELGGAIPLNGGAQVYLSKIFGELFGFLFTWSAVIVLKPGSTAIISIIMGEYLVRAGVGAEAESVSVWINKSVALVGLIAVTLLNCISTKLGTRMGDMFMFLKFIALLGVTIVGIVVALTGFSASGLANQDWKTKSWFEGTSTNASSWAVALYAGLWAFDGWDNTNYVVGEFRNPSRDLPRVIHTAMPLVILCYILANVAYFFVLPLEAINSSNTVAVAFGNQVFGPIGSLILALIVSASCFGALNASTFTTGRLVYVAGKEGYLPAIFGKIGIGAGDEPSMSTLRTRNWASKKLARMFGDEETGLFFTPVNAMILNAALTAFYIVVGEFGTLLTFYGVAGYSFYFLTVLGLIVLRVREPNLERPYKTWITTPIIFCCVSIFLLSRAAFAQPLQTVIVIGFVVAGIPVFYWRIRGRDQVVKRERSGSDAGYGWKFWKRFQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7C2</accession>
    <name>A0A3D8T7C2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GEgh 16 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_00193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7C2"/>
    <dbReference type="OrthoDB" id="3241054at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021476">
        <property type="entry name" value="Egh16-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618:SF3">
        <property type="entry name" value="GEGH 16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618">
        <property type="entry name" value="SURFACE PROTEIN MAS1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11327">
        <property type="entry name" value="Egh16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017541113" description="GEgh 16 protein" evidence="2">
        <location>
            <begin position="18"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW94430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="341" mass="34194" checksum="43FB3CED06AC7F2A" modified="2019-01-16" version="1">MLSSILYSAALVSLASAHGVILAAQGDAGSPASVGFQVDASIARNCTGISPCQQDTTIIRDSEITQNIVNECGRTELTGNIDVGENTEAALAAKAVTSVKAGSSVTVTLHQVNADGAGPYSCDIDMTSNAGIISQNLTVTNNVPGVNGLSSAKTTDFNITVQMPTNLKCVGASTGNVCTVRCRNNAVAGPFGGCFAVQQTDTTANVNSANQITTSQSLAAVQAQILQNQKDLPVAVEMNQNQGTTEALAAAVVANNLAGHSVTTTAFPTQTLAIENINGAAATSAAAAATTTSAAKASTTSKASKASKAAKGAKASKRAVDESAAAALKWAKRAMGAEDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7K2</accession>
    <name>A0A3D8T7K2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor CBF/NF-Y/archaeal histone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_00316</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7K2"/>
    <dbReference type="OrthoDB" id="1707486at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW94553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="196" mass="22071" checksum="4AC2CF0144BA4AC2" modified="2019-01-16" version="1">MDGDPSFQKRKKEEGEEKKNIELIEMNSRANAHTQKAQRKTISPQDVFAALQDDLEFPDFVPRLEAELAKFNEISTEKRNTYRKKVAADKAADKSGAAGDAEAEADEATEETRRDSNGQPAAKKARRESGHVDEVGDTHEKEIEEPEADEEEVEDEEEEEEEDALAALDRQVEEEELARADEMDGNDDEEDDSESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7V8</accession>
    <name>A0A3D8T7V8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ENTH-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_00367</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the epsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7V8"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070530">
        <property type="term" value="F:K63-linked polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000147">
        <property type="term" value="P:actin cortical patch assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16991">
        <property type="entry name" value="ENTH_Ent1_Ent2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000010">
        <property type="entry name" value="EH domain binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013182">
        <property type="entry name" value="DUF1720"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF110">
        <property type="entry name" value="EPSIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08226">
        <property type="entry name" value="DUF1720"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="10" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="ENTH" evidence="13">
        <location>
            <begin position="10"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="151"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="273"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="531"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="194"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="276"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="318"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="335"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="536"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW94604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="558" mass="61876" checksum="38D9B6D21F3DE0BE" modified="2019-01-16" version="1">MSKVMRSVKNVTKGYSSVQVKVRNATSNDPWGPTGTEMSEISQMTFNSSNEFYEIMDMLDKRLNDKGKNWRHVLKALKVLDYCLHEGSELVVTWAHKNLYIIKTLREFQYIDEDGRDVGQNIRVSAKELTSLILDEERLRAERSDRKNWKSRVTGIEEYGSPSNDIPRRQPRPQRAQRADEEDAEYRLAIEASKYQEEEDRKKRQSKQGEPDDDDLAKAIKLSKEEEELRRRELEDQNAQSLFDDDPIQVAQPTGFNQGYQQQGAVDWSGNPIDSGMQQQPTGFYSQPTGFQPQQTGYQNGFSNGFGAQPTGFDPYGQQQPQQFQPQQTGFNPYQQTSSPFQQQPQEVPPMPTGTNNPWATNQQTQVQALQPMKTGSNNPFASSFARPQTAQPAKPTLATLQEQKTLSHFNSISNFNNQPAQPAQPPKPQNEHEARLNALLANGDGMDTFGNTGNLRIPAQHTAPGTFVNSAGAGLNKLHSQQTGTNPFLQTQFTGMPQTSYGGNTSGFGAAGHQMPAATGPAGMANGFGGGYGAQQSSNPFGARPQQQNGGGDLIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7Z0</accession>
    <name>A0A3D8T7Z0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Dialkylglycine decarboxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_00432</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7Z0"/>
    <dbReference type="OrthoDB" id="10261433at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00610">
        <property type="entry name" value="OAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005814">
        <property type="entry name" value="Aminotrans_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049704">
        <property type="entry name" value="Aminotrans_3_PPA_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45688:SF13">
        <property type="entry name" value="ALANINE--GLYOXYLATE AMINOTRANSFERASE 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00202">
        <property type="entry name" value="Aminotran_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000521">
        <property type="entry name" value="Transaminase_4ab_Lys_Orn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00600">
        <property type="entry name" value="AA_TRANSFER_CLASS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW94669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="456" mass="48946" checksum="DA952884CE098616" modified="2019-01-16" version="1">MPSSTISPMKVTGQQIYANVDEKALMATADATLLNYGTSFFPSVITHASGIYIYTADGQRILDWTSGQMSCLIGHGHEEVVKTIHEHAASLDHLFSGMVSPPVIQLAKALTDLTPPGLDKAMFLSTGSESNEAAIKLAKFYTGKWEIVGLSASWHGMTGASVGAQYHSGRKGYGPQMPGNYALPAPNAYRSQFRHADGSYDWETELNYGWSMVDSASCGSLAAVILEPILSSGGMHCLPDGYLAAMKKHCEQRDMLLIIDEAQTGIGRCGDIFAFNEAGIVPDILTLSKTLGNGLPLSAVVTSDKIAAATKEAGYVFYTTHVNDPLPAAVGLKVLEVVVRDNLVARSREAGKKLHEGLKKLESRYGCIGDVRGRGLMAGIEIVASRETKEPSLELGSRLSERMFELGLSANLATMASFGGVFRIAPPITITDEQLQTGLEIMEEAFRTTEGSNPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8I8</accession>
    <name>A0A3D8T8I8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamine amidotransferase type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_00646</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8I8"/>
    <dbReference type="OrthoDB" id="14446at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061672">
        <property type="term" value="C:glutathione hydrolase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008242">
        <property type="term" value="F:omega peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006751">
        <property type="term" value="P:glutathione catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01908">
        <property type="entry name" value="YafJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000045">
        <property type="entry name" value="Glutamine amidotransferase DUG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026869">
        <property type="entry name" value="EgtC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052373">
        <property type="entry name" value="Gamma-glu_amide_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43187:SF1">
        <property type="entry name" value="GLUTAMINE AMIDOTRANSFERASE DUG3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13230">
        <property type="entry name" value="GATase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="3">
        <location>
            <begin position="2"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="331"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="379"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="415"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="444"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW94883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="484" mass="53664" checksum="4483468CB120BF96" modified="2019-01-16" version="1">MCRFLVYKGSDEILLSKLILDPSHSILTQSFDSRLRLDMRRPHNGDGFGIGYYTEPKLGPEPCIFTSTIPAWNCVNLQRIASKTASHLIFAHVRATTEGSLSDDNCHPFCHGSLMWMHNGGLGGWKHIKRPLGARLADKWYLGVHGGTDSEWAFALYLDTLERMGHDPSSPPAEGFGPSVLRQAMLKTIQQINDFIKEIPQSTIDMERLDTRSLLNFALTDGHSVVCSRYVSSATDEAASLYYSSGTTWEAKSRKGDYQMDRRDKGADIVLVASEPLTFERESWVTVPTNSILTIHKQTVMVHPIIDEYYSYNPYHSRSSQFAQDKGLVTNEKSASPGATTPSAGKPENKTHLAPSNHHETVRSLSPQMHARTNLPDFSRSSTPGTTNSTCSPRARSPDFHHRDSSPNADFQRLSSHSDAPSSSLKSQEQGNTKKKREPPPQHTALNVNSNTSQDASPSRGLASRSSFGDPAKIAQYFPELHSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8W3</accession>
    <name>A0A3D8T8W3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily protein-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_00749</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8W3"/>
    <dbReference type="OrthoDB" id="3561359at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000082">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF7">
        <property type="entry name" value="DRUG_PROTON ANTIPORTER YHK8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="74"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="232"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="336"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="76"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW94986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="420" mass="46165" checksum="7E793815D40F5F2D" modified="2019-01-16" version="1">MASSATIGSSDASPRQTSSLSDTSKNPNCENMEEKLPQVPAPAPIEGYDRQFEVSFSGEEDPESPWSMSTARKWLIMSIVFMTSLCVACMSSIFSATYAQIEAEFHTSQIVATLGLSVFVFGLGLSPMVLAPLSEFYGRSPVYLLSMLFFVVWAVPCAVARNIQTLLIARFFDGFAGAAFLSIAGGTVGDLFPRSKLQAPMMIYTAAPFLGPELGPVIGGFINSYLDWRWTFYIMIIWASVQWALLCLLVPETYHPVLLRKKARKLRKETGDGRWHASIEKLNRSVAQLRLMKRREEQGGEPGGSEPEFCLPPAIVGAPLVTFGILWFGWTTYPSIHWIVSIIGSTFFSCGVILVFSGVFTFLVHAYPTYAASALAAHSFARSMFAGGFPLFGTALYDNLGFQWASFLLAMITLVMVPFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T984</accession>
    <name>A0A3D8T984_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha-methylacyl-CoA racemase-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_00892</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T984"/>
    <dbReference type="OrthoDB" id="16747at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050509">
        <property type="entry name" value="CoA-transferase_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228:SF5">
        <property type="entry name" value="ALPHA-METHYLACYL-COA RACEMASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48228">
        <property type="entry name" value="SUCCINYL-COA--D-CITRAMALATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW95129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="406" mass="43493" checksum="277C291DBA22BF69" modified="2019-01-16" version="1">MTAPPPLSGLRVLEFAGLAPGPFAGLLLADNGASVLRIDRAIPGQTYTTGNLPAPTADLLTRHKSSIAVDLKSVAGVSFVKRLVADADIVIDPFRPGVLEKLGLGPEVLLKINPRIIIGRMTGFRRDGKYKDMAGHDINYIAVSGALSMLGRKGEKPLPPANILGDFAGGGATLFQGILLALLARATSGKGQVVEANMVDGSAYLVSFPRMLTKTPMWSRPRGENTLDSGCPYYDTYETKDGKYMAVGALEPQFFALLLKGLGLSGKGIEKTREDRTTWPEMKSTFERLFKARTRSEWEQVFDKTDACCTPVLELGELENDSGREGDQRPAVTLRDTPSLAVKKGLTKRDASIGQGPGVEGEGFSGTALYPGQGGEATLKAWLGWEQGKHFTVENGGLVGKQQSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9M8</accession>
    <name>A0A3D8T9M8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_00894</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9M8"/>
    <dbReference type="OrthoDB" id="655030at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972:SF1">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46972">
        <property type="entry name" value="MONOOXYGENASE ASQM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="300"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW95131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="390" mass="42415" checksum="3E218277F3AE8F1D" modified="2019-01-16" version="1">MTHPRIAIIGAGPGGLTLASLLQRHNLEYSIFELRPKPNGPSGPSGSLDLHPDSGLLAIEACGLTSEFGRLSIDCSEDLILADKHGCVQHTDEGSGERPEVSRSDLSALLLSSVPKDKIHWEHKLVEVTPVPESGKWNLVFQSGPSQKFDLIIGADGAWSKVRARITDVQPHYSSVNCITLTIPHLSTKYPSLATLVGKGSYQACGDKKAIISQRGSQDSARIYLMLKDESESYLLTEGLTNPDRAALKNRLLTSTFADWSPILKSLVATACDEDIEPTVSSKPLYMLPVGHTWSNVPGLTLLGDAAHLMTPFAGEGVNAAMLDAVELAKCIISGVERKETPLVQKYEKEMFERANEKSEETWRNLGIIFADDAPKTFVELMKSYGPPPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9S8</accession>
    <name>A0A3D8T9S8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SMP-30/Gluconolactonase/LRE-like region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_01048</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9S8"/>
    <dbReference type="OrthoDB" id="423498at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052988">
        <property type="entry name" value="Oryzine_lactonohydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013658">
        <property type="entry name" value="SGL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G08990)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47064:SF2">
        <property type="entry name" value="SMP-30_GLUCONOLACTONASE_LRE-LIKE REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08450">
        <property type="entry name" value="SGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017662740" description="SMP-30/Gluconolactonase/LRE-like region domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="SMP-30/Gluconolactonase/LRE-like region" evidence="2">
        <location>
            <begin position="329"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW95285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="432" mass="47196" checksum="573653DF862F361D" modified="2019-01-16" version="1">MNLILSPKSFLLSISILAVNIHAQPPGTISPLAEPCGPSSPNDIICINKYAAVMPYHFFRQPSVDGVFEDTYGSTLVPNSTSWPLVANATFLIFDTEKAFPVLGSNPTYDFMFAVNDAVHEAPVYSPVTNKLYFSQLRGATSQPGFLPQLVVNLNVDPPYLGELVSDPPIYAPNGGTIHNGLIYWGVSGGNNSIGGIEERPGIATLDPTTNKTVTILNNYFGYYFNTVDDLFVDDKGDIWFTDPQYSWFNALTDTAPQLETASYRFRPSTGAVYLIDDSIIQPNGIAISPRLENCSSTYKRTVYITDSGAIAAPIAAEVGSPGTKFNTTGKRTVYAYDLTEDGNHIINKRAIYLAQDWVPDGLKVARNGYIVTGAGKGVDVLDTDGGLVMRVQTNFTVQNFAWTGADYKEFWIMGNSGVARVRWELQGQDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q3A9</accession>
    <name>A0A3D8Q3A9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_13205</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000028">
        <property type="protein sequence ID" value="RDW56383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q3A9"/>
    <dbReference type="OrthoDB" id="61390at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW56383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="349" mass="40234" checksum="59FA71AFA95EFE79" modified="2019-01-16" version="1">MDWTNKYFLGILTAVLVVFLTKRVAKNRSNGKVDRRTKRPLYRADHSILNIPLPPQSLWMNMGLWKDTEDFPTACRALLEEVLKSAQVLQDGVSDSNNNLDNTLSIIDLGFGCGDQCLYIKDALDHHRQRKIYNPWRRRIKAYVGITLEKPQLCIAQERLGLKQPNTNTEFEIYCADAARPASWTSDIRNAVSLACQNNDETGDHENWLLGLDTLYHFQPSRWPVIEYAKREWGSSLMAYDLCIAENLSTWQRTILRLMAFFGQSPFANWVTIPEYREQLVMAGYAPERVEIRDISEHVFGPLAGFMKKREVELDQYGLSIGRYRYAGKMFGWWGRTGVVRGCIIVARK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q4V6</accession>
    <name>A0A3D8Q4V6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_13183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000027">
        <property type="protein sequence ID" value="RDW56434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q4V6"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW56434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="148" mass="15562" checksum="13E44813363BB598" modified="2019-01-16" version="1">MLSGSNANHFTFPHIYQLAFLTPGKDPSNAFIRKLNCLEIPEDTSSLPSLEASVPNLSGAGVGVHLGQLQLGLGAGSRREAEVADDVPESLSSSAARLDRGSLGQLCMAKAGEEEVAPGGRIMKKNGKHTSLSHARRTPAVWYGRAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q612</accession>
    <name>A0A3D8Q612_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amine oxidase</fullName>
            <ecNumber evidence="6">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_12701</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a secondary aliphatic amine + O2 + H2O = a primary amine + an aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:26414"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:58855"/>
            <dbReference type="ChEBI" id="CHEBI:65296"/>
            <dbReference type="EC" id="1.4.3.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the flavin monoamine oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="6"/>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q612"/>
    <dbReference type="OrthoDB" id="5046242at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097621">
        <property type="term" value="F:monoamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001613">
        <property type="entry name" value="Flavin_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050703">
        <property type="entry name" value="Flavin_MAO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43563:SF14">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00757">
        <property type="entry name" value="AMINEOXDASEF"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="7">
        <location>
            <begin position="22"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="23"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="42"/>
            <end position="43"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="445"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601613-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW57251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="475" mass="51194" checksum="F4E4464AB75C505F" modified="2019-01-16" version="1">MGDISTSEMAKAVDVIIVGAGLSGLQAATDCHGAGLTTLVLEAKDRVGGKTCSVSNGRGGTVDVGAAWINDTTQRRMFALSQKFGIDVVMQRAVGEDIVQNDDGTVEMVPYGEYRLTKDETKELETFFEVIDGMGDKLDPEDPSTLANAAELDSMTLTQYCNKYMPGKVAPLMANGTARGFLGVEADEISALFYIDYVRSGFRLESLTSDLKGGAQYLRARQGWQTISKRLAADLPPSSVLLSTPVAAIHQSESGDCIVYSDSTKSTFRSKHVIISIPTPLYKHIEFYPALPARKLAVTSSTHLGHTSKMILIYDAPWWRDVGLSGVLNSSIGPLAFSRDSSVEADNQYSLTCFLVGEPARKWALLPLADRKSTFLEHVKVMFAPVVAKTGKPVPAPVDTIEQIWAHEPWIWGCPCPVTALGSLAEGAAKIRREAWGKIHFVGSETSVDYQGYMEGALSAGERGAAEVIAAVNTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q628</accession>
    <name>A0A3D8Q628_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_12723</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q628"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW57273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="104" mass="11272" checksum="7AEBF136317CC995" modified="2019-01-16" version="1">MTPSYDLENVQLSGNNSNGIIVGQPVQSEVATFQKNGVTSAKIGVKIVPLDRQTCGHKGEIFIPDDLPTTKNYTAVNTLETMPTSILLYRNMTTTLGTEKPMAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q6Q7</accession>
    <name>A0A3D8Q6Q7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SCP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12817</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q6Q7"/>
    <dbReference type="OrthoDB" id="3522218at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017803858" description="SCP domain-containing protein" evidence="1">
        <location>
            <begin position="19"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW57367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="307" mass="32732" checksum="AC08CFD8D3FB35F5" modified="2019-01-16" version="1">MLFLQSFLLLLSMSDTFATAERAPRLILRGARARNAAAPEAGLAAREPEPEKLAKRACPAGTRYLYHIPGSPAAEVCIGTWVFASCTIIVASVSAVFVTLSITSANWVKSQVSDASSAGPPAKKRGEEEPLTWGALYNYTKAAGINRIEGDACALLSNTSSTPAALASYASGNLTDLDLDPTSPKGIAATIPPSPAHQYVATGLEIHEDGFSASFAPHNPDPLQQRSTCNEQIHIHYWASAGHTGTILSSSDVQTLVKTALSDSYQKNYQAACYELDNNGNWSGAYRICYNNNRSQIGCFTCNGHTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q7H8</accession>
    <name>A0A3D8Q7H8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12596</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q7H8"/>
    <dbReference type="OrthoDB" id="3540210at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="536"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW57795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="660" mass="73234" checksum="C29C50D70CD70139" modified="2019-01-16" version="1">MNSTSSIYQGVWIDWSHGAILGTTLTLTKAHGAILIAALAFWVTAATSGFWSIAKFTIHQLRASREEKSKRHDGLYRQQQAILRNSSSPLSATWEILRLSWTWRRAEVSGFIRSAHLTLLAFMVFSFFLAATILTSRVQNSAFNNVDVLIVSPNCGGVYMRDGASSASRLLRVMSQTLSASNWARNCYGNQNNLQCGTYAVKEVPWTVNANASCPFANETCRLGVTTAYDMDTGLVDSHSILGINAPRSERLFFRRKAVCSPMRLGNYSFYENFTYSDDAPSDRVVRLYLGAYAGVNYTYEYNTHDYSESGYTTVSSHQGDNSSTNWIPIAPIYRDDADISFMFLTASSVRYSQPVDDPLFSAHTMDNTTVPGSVYYFADYWVSTIGCIDQYQYCKPAEDGDAAPICTELTSNIKSVNGLSTLGLSAFQLATADHIAWNMGYSNIEYSISGRGSSALLAKESLFDLAQFDLPNNQWQIELGNWFNTSLARIQQDVVAFSAGPTNLGPDGLISLASTPIERLVCHSQKVRDGNYSNFSMLGIFIIATVGTVIILLGLTIDLGVGEIKRYLKKGTYSRISWALDEKLQLQRMAYEGSGWRSWTGGTDIVPVMTTAHDLGIYDIRDTTHPSIMPRSSQNSEGVEFLNHYINLDNKGAIEERQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q9H2</accession>
    <name>A0A3D8Q9H2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12423</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q9H2"/>
    <dbReference type="OrthoDB" id="284184at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="45"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW58493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="276" mass="31344" checksum="563CAC5EE3C73E27" modified="2019-01-16" version="1">MMTAPVILKAYYTAPEGQVHYRYAKALVKDEKKCPIMFMHMSASSSFIYEELMERCAVEGYDCYAPDMPGFGASYNPNYMPEGIKYYVEVFMLLAKHVGLTKFHAFGHHSGASIATEMATLYPEQILSLTVVGPCLLNREEQIEHTSGGLLEYGTRPVMDGSHMMKVWGILRKQEAEWDVLKMNQEAIDWIRAWEGKVQCYTNVFSQPMIKIMGDVRCPVLGMSSEKDILYPYFPRLKEIKPDSTTAIVQGGDWEVMKDAEGCCNAFVDFAYKLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q9Y2</accession>
    <name>A0A3D8Q9Y2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Isochorismatase hydrolase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_12194</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q9Y2"/>
    <dbReference type="OrthoDB" id="1739143at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF1">
        <property type="entry name" value="ISOCHORISMATASE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="118"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW58264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="239" mass="26566" checksum="BD0FB08321D9C798" modified="2019-01-16" version="1">MSSNPKFYVPVDLKRTALLVSDVQSQILSRFPEPEQTAYLERVQRLLDLFRAEIKKAHKERNQTSESSFAPTSLYDNCPLIIHHVLPFGLNSNAFISPYNKLASWVRSLEAQGFFKDTTKTDPNTPQYAIPPSMAPPSGWGTKDEIIIPKIQAGSFSSSDLLAYLRARDIKHVVLIGLTTMGSILGGARLGSDLDFHIIIPRDAVMDDNAEVNDFLLAKVLPRFTDVVDVDDVLGLPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QBK3</accession>
    <name>A0A3D8QBK3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_11954</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QBK3"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="38"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW59030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="191" mass="21035" checksum="F53B73F9EAAA313F" modified="2019-01-16" version="1">MEVASEAVVFDDTKHCSLLPAIAAVHMACITTDGTIATFLPPLSQEKITLWWEDHSKDSERKIILHLATEPSTGKFAVAGVVMLVNEGSKNEGGRFRGGVSKLLVSPSYRRRGIAKQLMGKLEKEAREWGLTLLVGTLLELLDTEVGSPAEKVYPRLGWIKVGVIPKFEQSPADGELKDNVFFYKNLLLDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QEZ3</accession>
    <name>A0A3D8QEZ3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_11903</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QEZ3"/>
    <dbReference type="OrthoDB" id="5595695at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016810">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01299">
        <property type="entry name" value="Met_dep_hydrolase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051781">
        <property type="entry name" value="Metallo-dep_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057744">
        <property type="entry name" value="OTAase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43135:SF3">
        <property type="entry name" value="ALPHA-D-RIBOSE 1-METHYLPHOSPHONATE 5-TRIPHOSPHATE DIPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="1">
        <location>
            <begin position="62"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW60297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="430" mass="47283" checksum="B66917F9C2AA8585" modified="2019-01-16" version="1">MSQYTIHTSSAFDPKLKKFVENVSITVDSTTGLIVRVFVRDEENEPLSKIMMDGDVDLRGKFLMPGFVDAHTHIFLHSYDETPALQQKRDESMAERVVRAVNHCRTALLAGYTTYRDLGSEGMQEADANMRDAIARGLTPGPRLFVATRVLASTGSYEPRTENSNGGHCLPAGGEAVDGIDEIRRAVRRRIAAGADIIKFFADYRRRIMRSPPAQQHPYIPSVLHPPREPNPDYMVFSDEEMKMIVSEAALARCPVAAHCCTLEGALAAIEAGVHTIEHVYFATDDMFRAMVKKNVVLVPTLAIAEKLHKARFPTILKQVKRAYELGVRLACGGDTGTFSHGDNVRELELMIEAGIPVVDVLEACTVGGWDACGGDLCGIRFGWLEEGLQADLIAVDEDPVISAGALRKVGFVMKDAKIWKQDGKPLGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QF13</accession>
    <name>A0A3D8QF13_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_11854</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QF13"/>
    <dbReference type="OrthoDB" id="2148442at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF4">
        <property type="entry name" value="D-XYLULOSE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alcohol dehydrogenase-like N-terminal" evidence="11">
        <location>
            <begin position="56"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase-like C-terminal" evidence="10">
        <location>
            <begin position="208"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW60248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="390" mass="41622" checksum="24B463D65FD2CBEA" modified="2019-01-16" version="1">MAPSVLESQQESITLSSKSQTATKPASGASEFKNPSLQVTADHQIKLVEAPILKPGAGEVLLHVKATGICGSDVHFWKRGAIGTLTVDGDCILGHEGAGIVLEVGDGVTNVQKGDRVAIEPQVPCGECFSCTSGRANLCPEVQFAGVYPYHGSLQRFKVHPARWVYKLPDHMTFAQGALLEPLSVVMHALSRTHLSLGRGAVICGAGPIGLIALACSRASGAHPLVITDLEPKRLAFAKQFVPSCQTYQIDTSKSAEENAKGIRKLFGDAEYDAPRTVLECTGVESSVVTAAFTVRTGGDVMVIGVGKDVMNNLPFMHISLSEINLKFINRYTDTWPAGISALSGGILNLDMLVTHTFPLEEAKEAMHLCSDVSKGSIKVQVVDDMDVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QIE4</accession>
    <name>A0A3D8QIE4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_11498</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QIE4"/>
    <dbReference type="OrthoDB" id="3535030at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW61606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="212" mass="23646" checksum="910E72B9743FD96E" modified="2019-01-16" version="1">MSSPQKPTNSSSSAPSYKLIAIITLSFLAATALCTGFALIVMEIISIPFLTPALRPLRPYLELGYKVVKPAVMIVWPLLTLGACLKIHVHSDFPSKSRWRMSSGWMFLQQLGMIITKVGTILTSKECPCGLRECWDAWVLLALLVVIPVATWKGWRWDFGYIDRYVDRLASESWEEDAKKKVQDAETGVKKDTDAAVEAAVSREAPEMPEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QKZ8</accession>
    <name>A0A3D8QKZ8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NAD-dependent epimerase/dehydratase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_10798</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QKZ8"/>
    <dbReference type="OrthoDB" id="2130169at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051783">
        <property type="entry name" value="NAD(P)-dependent_oxidoreduct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079:SF6">
        <property type="entry name" value="NAD(P)-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48079">
        <property type="entry name" value="PROTEIN YEEZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="1">
        <location>
            <begin position="5"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW62496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="325" mass="34788" checksum="EA3BFC4B584B5F6D" modified="2019-01-16" version="1">MAPRIFITGVSGYIAGQLATDLSKQHPEWQLVGLVRNDDQAQKIAARLPAIQTVLGDLSSHAILMREAEKADVVIQAADCDDAALVKTLIKGLAQGGKGGSFIQISGAASIADAPNGYGQPSSKVYDDVEDIAEITTFDPTHLHWEADQAVLHEGQALGVKTAILVPTMVYGDGEGPVKTKSMTIPWLVDAIVKRGKGFTVGEGKSAWAGVHVKDLSVAIILILENALTSDGGKAVWGSEGVYYVEEGEYAFADIVPKLVESLKSRGMIKCLDIDQVSTEEATRINPYSLLIWGANVRCRATRLRALGWQPTQQTLYELIASGTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLD2</accession>
    <name>A0A3D8QLD2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cysteine desulfurase</fullName>
            <ecNumber evidence="3">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_10938</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. Plays a role in both tRNA-processing and mitochondrial metabolism. Involved in the 2-thio-modification of both 5-carboxymethylaminomethyl-2-thiouridine in mitochondrial tRNAs and 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) in cytoplasmic tRNAs.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(sulfur carrier)-H + L-cysteine = (sulfur carrier)-SH + L-alanine</text>
            <dbReference type="Rhea" id="RHEA:43892"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:35235"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="EC" id="2.8.1.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLD2"/>
    <dbReference type="OrthoDB" id="10250117at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990221">
        <property type="term" value="C:L-cysteine desulfurase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000003">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000002">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00331">
        <property type="entry name" value="Cys_desulf_IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020578">
        <property type="entry name" value="Aminotrans_V_PyrdxlP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010240">
        <property type="entry name" value="Cys_deSase_IscS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02006">
        <property type="entry name" value="IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010611">
        <property type="entry name" value="PRK14012.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601">
        <property type="entry name" value="CYSTEINE DESULFURYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00595">
        <property type="entry name" value="AA_TRANSFER_CLASS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="12">
        <location>
            <begin position="115"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00045623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00050776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW62636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="515" mass="56265" checksum="9A0EC8CB6C1F6C2D" modified="2019-01-16" version="1">MSSIASNTLRQASRLCLTKAAPSAGLLRASALPRTAIAAQRSSRRGYVSETKKDNAQVNVDSAIRAEQKAFFKETGVKADEMSVPGTTVSADAMMSPMAGVLKQATVMDEGQRPIYLDMQATTPLDPRVLDAMLPFYSGLYGNPHSRTHAYGWETDKAIEEARENIAKLIGADPKEIIFTSGATESNNMSIKGVARFFGRSGKKKHIITSQTEHKCVLDSCRHLQDEGFDVTYLPVQENGLINMEEFKAAIRPGETAIASIMSVNNEIGVIQPLEEIGKICRANKVFFHTDAAQAVGKIPMDVNKMNIDLMSISSHKIYGPKGIGACYVRRRPRVRIDPIISGGGQERGLRSGTLAPALVVGFGEACRIASEELEYDSKRIKKLSDRLLKGLLSLEHTTQNGDHEHFYPGCVNVSFAYVEGESLLMALKDIALSSGSACTSASLEPSYVLRALGSSDESAHSSIRFGIGRFTTESEIDYVLKAVQERVTFLRELSPLWELVQEGIALDSIEWSQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QM24</accession>
    <name>A0A3D8QM24_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">endo-polygalacturonase</fullName>
            <ecNumber evidence="3">3.2.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BP5796_11002</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>(1,4-alpha-D-galacturonosyl)n+m + H2O = (1,4-alpha-D-galacturonosyl)n + (1,4-alpha-D-galacturonosyl)m.</text>
            <dbReference type="EC" id="3.2.1.15"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.15" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QM24"/>
    <dbReference type="OrthoDB" id="1546079at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000002">
        <property type="entry name" value="Endopolygalacturonase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050434">
        <property type="entry name" value="Glycosyl_hydrlase_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006626">
        <property type="entry name" value="PbH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31884:SF1">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00710">
        <property type="entry name" value="PbH1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00502">
        <property type="entry name" value="POLYGALACTURONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9 13" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017627221" description="endo-polygalacturonase" evidence="14">
        <location>
            <begin position="22"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDW62700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="381" mass="38447" checksum="AC789CA2CCF5878A" modified="2019-01-16" version="1">MVHFTKTLGLALSSAAVLVSAMPAPVPTAAPNLDEAQTLQKRTSCTFTGSNAAAVSASAKNCATVVISAMTVPSGTTLDMSKLSQGSTVIFEGTTTWEYEAWSGPLLQIEGTDITVKGATGNLLDGNGAKWWDGKGSNGGVTKPKFFYAHSLKGTSSITGLNIQNTPVQAISVNSASGLTIDSVTIDNSAGDVTDGGHNTDCYDVGSSSDVTISNAVCKNQDDCLAINSGTSITFTGGTCSGGHGLSIGSVGGRSDNTVETITISSSSVSSSENGVRIKTVSGATGTVKGVTYKDITLSDITDYGIVIEQDYENGSPTGTPTSGVPITDLVIDSVTGTVASSGTNIYILCASCSSWTWSGVSVTGGKTSSKCTGIPTGASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QTK7</accession>
    <name>A0A3D8QTK7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxymuconolactone decarboxylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_09858</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QTK7"/>
    <dbReference type="OrthoDB" id="2567457at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846:SF11">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW65166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="185" mass="19419" checksum="3FE7C302D6DC6029" modified="2019-01-16" version="1">MTKCTGASRFPPLTPANGSLDETQALEYEYVVNSRRKSMAIRSSPYTPTVLQPWVKLQLAVAALLTPLESEAAVLGVLSVTKAAYGIYAHTLLAEKAGYTLEQVKAMLAGTCPSDITARQGAIHTLAIKLAQTRGPLDMESFESAVSVLGRAGVASAVQQSAAFMYAAMMLNAGDVGLPLGVDAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUP4</accession>
    <name>A0A3D8QUP4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_10174</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Cytoplasmic vesicle membrane</location>
            <topology evidence="1 6">Peripheral membrane protein</topology>
            <orientation evidence="1 6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Membrane</location>
            <location evidence="6">Coated pit</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
        <text evidence="6">Cytoplasmic face of coated pits and vesicles.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the clathrin light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUP4"/>
    <dbReference type="OrthoDB" id="5512at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032050">
        <property type="term" value="F:clathrin heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000996">
        <property type="entry name" value="Clathrin_L-chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10639:SF7">
        <property type="entry name" value="CLATHRIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01086">
        <property type="entry name" value="Clathrin_lg_ch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="145"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW65482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="236" mass="25411" checksum="91BD18AF1EB0A758" modified="2019-01-16" version="1">MADRFPSLEEFDSGAQTEAQGDGISGDDFLTREKALLGDDADQFTSGNDNTAFVEDGDDDLLGGGGGDANGDMNEFESSFPAIDSTNESMAPGGTITGTPAPYQSSYQPPTDEEEPEVITQWRERRDLGLQDRAEKSEARKAETIKTAQQNIDDFYENYNSKKEKTIAQSRREAEEFLANREDTSAGGTSWERIAKLVDLSGKGAKGGASGGGKDKFREMLLALKKDENAPGATGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QVF3</accession>
    <name>A0A3D8QVF3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_10186</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QVF3"/>
    <dbReference type="OrthoDB" id="407275at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF15">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017569703" description="FAD-binding PCMH-type domain-containing protein" evidence="5">
        <location>
            <begin position="20"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="62"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW65494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="511" mass="54536" checksum="A093B607EF2A6741" modified="2019-01-16" version="1">MATLITAGLLLLQSISTNALPFDTQLNARQTSLVDCLEAGNVPLTISTYSNYTEYQESYNLRVSYQPAVITLPVTTDHVSLSVTCAAAAGVKVQAKSGGHSYGSYSSGGQDGSLIVDLENFNTVSLDNSTFIATVGGGVRLGNLALGIYNQGNRALPHGTCPGVGIGGHFLHGGYGHGSRHWGLALDTIVGLDVVLANGTFVHASATEYPDIYFAMRGAGDSFGIATTFYLQTEVAPAQLVNFLIDVSAVLDSVDTVTTAFMTLQNWVLTSSLVNGNLSFGLYTDGTSLTITGWYFGDLSYFQSTIQPALLQDFPTPNSADVTAKDWLDSLLFIEGGSPPGPLAQPLTGYSAHDTFYAKSLVTKNAEPLTQAAVQSFFDYVINTGRSQSESWFTIINLYGGLGSQINQPSNSSSAYSDRDSLWVFQNYGTSGTAAYTQGITEFVTGLNTAITDVQTDGDFSAYLNYLDPMLSKQDAQDLYYGADLAAQLLTIKNQVDPDCVFWNPQSICAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QXX8</accession>
    <name>A0A3D8QXX8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_09388</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QXX8"/>
    <dbReference type="OrthoDB" id="3599804at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="111"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="243"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW66639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="314" mass="35192" checksum="1DC7D9D015DFC173" modified="2019-01-16" version="1">MATPAPKEPVVKHPGERLSDYFDNFFKTIVGVCTLGASITFAKIVQTPVTPWTDYGVSKDTVQNYLAISWLCFILDLVITSFAASALSLYRPQAIKYFGTVDSRERRIVAWYATLVSATLFGLLIAAFIFLCLVVAAYTGSIGWAGVGFCVFFGLLGFGSIVWQSPIGEKAVDESLKSRRRQHQDYGTPEKKVGFGEPRLSWESYQDNNGTTVGRRYVEDRLTTIPPLSAAVPYYTTELRMSRASRNSAAPSYNAVGYEKEPRRPENTDMPIQYDEKAKSISSLETDEYNDDRPYDNQVPAPQEGDRYEGYSRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYB4</accession>
    <name>A0A3D8QYB4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">O-methyltransferas-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_09535</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYB4"/>
    <dbReference type="OrthoDB" id="10251242at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050362">
        <property type="entry name" value="Cation-dep_OMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002935">
        <property type="entry name" value="SAM_O-MeTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509:SF14">
        <property type="entry name" value="CAFFEOYL-COA O-METHYLTRANSFERASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10509">
        <property type="entry name" value="O-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01596">
        <property type="entry name" value="Methyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51682">
        <property type="entry name" value="SAM_OMT_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW66786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="250" mass="27794" checksum="24E5FE2461BCA7CA" modified="2019-01-16" version="1">MKENYTALYPNEQVATAVGDYAFKHSTALPQHITEYHTIGSSHEKANYMISPLQAQFQLWMAKALGTKRILEIGVFIGFSTMAWSEAVGPTGHVTGLEFSPEYAAEAKKAWSARNISNIEIIVGDAKESLQTLSRTLTEPYDLIFIDADKVSYPTYLSIILSSSKPSSEKRLLKKGGVIIADNILRRGLIADSSDANPYREKLMKLDGGLWRSGDMDALDKFNKEMVGNERLETFLMPMFDGLGMARLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYB9</accession>
    <name>A0A3D8QYB9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">STAS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_09420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYB9"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.24">
        <property type="entry name" value="STAS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011547">
        <property type="entry name" value="SLC26A/SulP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001902">
        <property type="entry name" value="SLC26A/SulP_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002645">
        <property type="entry name" value="STAS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036513">
        <property type="entry name" value="STAS_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52091">
        <property type="entry name" value="SpoIIaa-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50801">
        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="454"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="6">
        <location>
            <begin position="502"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW66671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="713" mass="77684" checksum="B908A9CFA0C6B171" modified="2019-01-16" version="1">MGRLGNKISAIKDLITTDTNLRRAGRGIIRGWKALPSATGQYLVRRVPIVQWLPNYSPQWLVNDLIAGVTNGVILIPQALGFAVIAGVSLQSGLIAIVLPQAIYAFMGTSKDMSIGPTSTTAILSRVIIPTFAKHGVPALITIPAVSVATGSLSLVFGLLNLGFLIDSLSVPIIHGFLLGVALVVIQAQVPLLLGEPGVSDLSFITQGMAIVNKIGTSNPLAIAIGFSSVAFLFLVQFVGKKWGDKFTLVRIMSQASSLVVLIAFTLISFFINKDLKQAVWLVVGVVPEGLPAPKLPSFSLLQNVILISIPLFLSTGLEHLALAKGFAMRNNYEIDTSQELVSLGIANIASGLMGGMPVGSNIARTSVLEVSGVKSPLSGVFTALFIILAITKLNTILFYMPLAVLGAVLLVAVIECQPPQAILGKYWKISFIDFAATIFTFNVTLIATPEMGIGSAVIFLFIYTFLRLMFSYAKVITVMDLENQYGMDPLAGVYGNMIPMGTQAFTMGGSVMFMNAYRQKRCIMDTIQTLHSGNSVPIRSRDRVWSDLTAKHITRLRRKANVITPERFIPHIRLLILDFTHTTFVDSTGIQMLEDLKKDLIAWGGDDIEFRFVGLSAAVRERLQRANWKLASYDEALSGLDPGFDVYFELLKPALEGRGLWRPEEKLDFGFDTGNIMTRSDDGYDEYETKKGVIITTNVFTKNGKAYKRSTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYJ4</accession>
    <name>A0A3D8QYJ4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative phenylacetyl-CoA ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_09621</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYJ4"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF422">
        <property type="entry name" value="BCDNA.GH02901"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="23"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="457"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW66872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="560" mass="61213" checksum="F71C573033195BCE" modified="2019-01-16" version="1">MLDEAYGRRPHNASKNPFTCGLSGKTFTGLEMVERVENLAKGLSKEFGWEPNKGTEWEKVIGIFALNTVDSMTLAYAVHRLSGIASPANAAYSASELEFQLKSAGAKALFTCIPLLQTSLEAAKAAGIPNDRVYILEMPKEFSGNEALPFKTVGQLISEGSKSGKLEQLRWEKGQGARQTAYLCYSSGTSGLPKGVMISHRNVIANIIQICLYEKPTRDKRSPENKTEVGLGLLPLSHIYGLVVIAQASTYRGDGVVILPKFELQSYLYAIETQKINTLYLVPPIIIQMAKNQVACKKVDLSSVNCVFTGAAPLGAETADELQKIYPSWKIRQGYGLTETCTVVSSSVEHDIWFGSSGSLLPGYTAKIVTPDGNDISGYDQPGELVVQSPSVVLGYLNNENANKETFIDDTDGKGRWMRTGDEAVFKKGPNGYEHVFIVDRIKELIKVKGLQVAPAELEAHLLAHPSVADVAVIPVPDDAAGEVPKAFIVKSSSVGLEENDRMVARDIAKHVQDHKARHKWLKGGVEFIDVIPKSPSGKILRRLLRDKEKESRRKKGAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYR2</accession>
    <name>A0A3D8QYR2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_09685</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYR2"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF0">
        <property type="entry name" value="CELL CYCLE SERINE_THREONINE-PROTEIN KINASE CDC5_MSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="340"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="113"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="675"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="36"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW66936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="698" mass="76924" checksum="E84D2F319BA8F7AB" modified="2019-01-16" version="1">MSASSATSPLQTLAFRSSQGTECSTSTQATPACDMASADSAPLSSASNTAVTPPTTIDRTISQAASQSKSYDQISSHSKCCKLQDEHHTGYDAACHPTDHVLQLPELNMAALASRKADDDAQTQPGPAAPDAAKQKITRHRIRRSVSHLFHMTHLHSPINHTIASLNKAPLKSANASEPTLLRDWKINTLPETSAGAPKASTSTSTSSLLNETFSLAAPEIKASLACRPTRRRSSAAPSFLEAVHCHVPRISFAALDNKRPEFDKRSRASSMDLETALKHEECLLHGPEVEEIQQHMWGISPPTGAGRKARRLSQKITDDFNVHTTELYDDYSDQSKLVGRRGRLLGRGATAQVKLMIRKGCSSDLYAVKEFRGKAKHEKTEDYEKKVKSEYSIAKSAHHPNIVKTVSLCIHNGRWNHVMEFCDQGDLFHLVQKRYLCDKDHLKDRLCLFKQLVQGINYLHGHGIAHRDIKLENLLMTEHGHLKITDFGVSEVFCGIHPGVRSAGGECGKEMKEVRLCTPGICGSMPYIAPEVIAKQGEYDPRAIDVWSAAIVMISMTANGTLWPEAQLGSSMVYDSLVGGWQKWNSTHKDEGCINESDYPYVSFFDTFINPPALRRILLTMLNPDPSKRVTIHKVATNRWLKTIECCQADSEDGDEAVVIDASKTCPSKALKKIGHHNHLPPEKHAGHRIVRLPGSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QZ30</accession>
    <name>A0A3D8QZ30_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_09832</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW67083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QZ30"/>
    <dbReference type="OrthoDB" id="4158087at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW67083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="38157" checksum="E9333DC7931D8A59" modified="2019-01-16" version="1">MASVLAMTGIYCVLDGTLTDASIELEAWRQKGKVIEKISDHLQSNQVQITDAVIASLATLISIMNMNGVFHMAAVHLNGLAEMIHARGGLSTFQHNHHLARVITWADIQTASGLGRPPLFPLLPLFPRAWENSLPRNPLIEAESESLALLRGIDGAAEALGVLTMLRRIIWLQNSARVTSISSVATTEGLINAAEHIILRYITEHASQQSSSAVAPAIFAAAHVFIYCSLRDIPKRAKIFQILLFRLQQALLNMDHLTLDGNICWPMIWALFIGYAAGLRMDKHRNIYGEWFLLKLHTVLNAIKQNGELDKDLLKEHMMEFLWVDRLCQVAFAHIWDGCRTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QZ98</accession>
    <name>A0A3D8QZ98_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_09824</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW67075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QZ98"/>
    <dbReference type="OrthoDB" id="10673013at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW67075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="498" mass="52668" checksum="DFB3FE6676C8FED1" modified="2019-01-16" version="1">MAFAIDTGLRINTDVIATTTVGEVRCYVGTGSRADFGRARTSTFTSDASLTRKTAISTTATVAGRLHCPAMQVSEARQALLQVPQLPTSVEGSVHWPEQTTDDPGQAHCPLTQDSPLGQALLQVPQLLALLVRSVQLPEQTTLPVAQTHVPPTQVSSPLHTLPQVPQLFESSTGARGTGLIRCTSISTTTTVANISGHVGTCTDADRIIRWACTLTIDATSTRCAGVPAKPTVASISGNIGVPASSTVATISEDVDTYATAESTPCGAGTLTINAACPRWAGVSANATVASIGLGHINPGVVVVLDLVDDVVLDVELILDVELEVVLDVELEVVLDIVLDVDVDSDVELEVVLDVELEAFFDVELEVVLDLELEVVLDVVLDVDVILDIEVALDVEVALDVDVVLDVNVVLDTNVVLDTNVVLDVDVVLDIDVVLDVDIVLDVDIVLDVDVVARLANSIYLNVAVNFDLWPNIVKCTYGVTKTSLSVVVAVITDFKDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R306</accession>
    <name>A0A3D8R306_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histidine kinase</fullName>
            <ecNumber evidence="2">2.7.13.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_09005</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + protein L-histidine = ADP + protein N-phospho-L-histidine.</text>
            <dbReference type="EC" id="2.7.13.3"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.13.3" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="303614at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009927">
        <property type="term" value="F:histidine phosphotransfer kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16922">
        <property type="entry name" value="HATPase_EvgS-ArcB-TorS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.130:FF:000050">
        <property type="entry name" value="Related to histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000010">
        <property type="entry name" value="Sensor histidine kinase RcsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2300:FF:000158">
        <property type="entry name" value="Sensor histidine kinase/response regulator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000700">
        <property type="entry name" value="PAS-assoc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004358">
        <property type="entry name" value="Sig_transdc_His_kin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047:SF74">
        <property type="entry name" value="HISTIDINE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43047">
        <property type="entry name" value="TWO-COMPONENT HISTIDINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00344">
        <property type="entry name" value="BCTRLSENSOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50113">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PAC" evidence="11">
        <location>
            <begin position="1137"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="10">
        <location>
            <begin position="1196"/>
            <end position="1251"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="8">
        <location>
            <begin position="1413"/>
            <end position="1639"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="9">
        <location>
            <begin position="1998"/>
            <end position="2120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="373"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="425"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="552"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="739"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="809"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1036"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1255"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1641"/>
            <end position="1728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1758"/>
            <end position="1814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="379"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="559"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="592"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="839"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="921"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="946"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1036"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1278"/>
            <end position="1300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1307"/>
            <end position="1318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1659"/>
            <end position="1677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1688"/>
            <end position="1714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1759"/>
            <end position="1786"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="6">
        <location>
            <position position="2050"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW68348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="2135" mass="231950" checksum="A08232F72AB0D131" modified="2019-01-16" version="1">MPKPPKSPLEKPTPSSHPRRPRRHSSEKSIAPSSSSTKHGVRSGHTAVSKSKEAMSNVSSGPTPPVEPESDRDAKLAGAVTTDSSPLSKAQEGVRDALGLGNSNTQRVDAELGGRLPSGKVPAPSSTSAEEVERLRAAVNAQIQLNQHRERLAKQLGDRESQSNILTPTSTGKARVSPIHEETMSPSLEAAFASPLPTGMETSSTESAHTIRGGVTPAAVTARTPSYPFPPMRMPSTQMNFSGHRPFTALSPTVNPYNFAGGSFDATTPYDRVMSGSVTPASTLNFKPASGFESKEDPNFPSPNLYDLTLMLSAEPGLDPWWTAVCQIMKDDFRAERVTLSVPADSTDLENVPWGQKATFNVHEEDELSLTYLPRGSSLIPSSVGTNETSNSDDIGTGNGDSPPAGASLLEPVRPGLMSRHSFTSYEDTKRDPFHTSESGRPAVARPNTLARSQSYLSSHRSNNSLPPRTGTLQNAKLNLQSLQDHMLFENESSPTGWENVEASSREVRGRIFPVLQALDYEADPLIDSSGIIRVLERGRVIALTRDYPYLGGGQDEISGGSKSSQKSGKSFKEPSKDKKKQKAPEIPSRVSSFLGSQGSRRSSRSVRTSTADKGGKSGHSATSRVVFDENPPALVPNYEEYEQAPPSPWAQSPAPSPAVRPETSENPFFSNTVVEEASFDPGDSPMDYSSTQQVEAIGIDRSWTVLHIPLIHPLLSKPVQSFRLDAAAMESKMAAARIKDSSKQVKQQDTGESVEPTKEKRTAIAILSILSPIIPYPSSLRNSLEALAPHLATSFSLCRHFSNLETEVAGLSRKRPQTTGFGAVAGGGRYSERVSSRHVFSQSPAEDEGPQQSTGGSITSPSDYSGVSHSNNGSSPVGTPGWDPGSVGLTPLDKRTSTSSPSYNAGDGYFSSKTRPGLNRGNTVGSASSIMGARRTSKETPSTETRPHHIQRDDELQPEATSKTGSSEKGRTPTNAADDSSRSDFEPEVQPEGSLPHLDTRTASSQTIYKAEKNHTQLHSYGADFGATFQSLPATSTPAKLSSTKPHSRPGSLAGPTDMPPPSDRLKGLMLDSLPAHVFVALPQTGEIVWVNSRYLTYRGQSVAELYQDPWASIHPEERDEYLKSWTHAIKTGEQFSMQVRIKRFDGNYRWFYTRAVGSRDTRGVIVQWYGSHMDIHDQHIAEVKAARQEEIEASEAKHRLLANLIPQIIFAATEDEGVTFANEQWLSYTGQSFEDSLGLGFMDYVHPEDLAKCRIPTDRPPTPSQHRSKKPAEPSRTPSQCSSGGKSSTISDAQTETTVKGVHQSLSRTNSSNSDSVYEMPTADISELARSGVIKVSTDSNGRLSYTTEVRLRSKNDEYRWHLVRCVEVDNINLGSGDGSWFGACTDINDHKLLETKLKEAMDSKGRFLSNMSHEIRTPLIGISGMVSFLQDTVLNDEQLDYTNTIQSSAKNLLDIINDILDLSKVDAGMMKLSYEWFYPRSLVEEVNELVSSMAITKRLELNYVVDVDVPEMVKGDKVRIRQILLNVIGNAIKFTAVGEVFSRCRVYRHPSVDTRENEIMLEYSIVDTGSGFTKEEADMIFKPFSQIDGSSTRQHGGSGLGLVISRQLAELHGGKMVGSAVPGEGSTFTFTAKFGLPTSDDYPEPVGTPLPGKTPSIESSLGSIVPNEASTAKQSGGKPFVPGTMVQSPAATSESSMDSPAVASSGSSIPSHKSDRSHGTGRSSISSIAQGAATMFGEAARTRGSDLAQMKFALPTRTSSGSASEASENLAPSFTLRQESSGDTIKPIDRRSPGLFTAGGTPPPPLSRDSSGLSLELKQFRPPMYSILLICPQKHSREATKQHIEITLPKDIPHQITPMSSVEEARAMISGEESVIFTHIVLNLPSAEEIVALIDQIFQSASFPQTSIVVLSDPVQRQEVIKLATSYDYDQLAKDNRVTFVYKPVKPSRFAVIFDPDKERDLSIDRNRSNAQQQVANQKQNYLDVGKRLGNKGLKILLVEDNLVNQKVLLKFLGKVGIAVELAMDGVECIEKVFSHPHSFYSLILCDLHMPRKDGYQTCREIRDWETSHSHSKMPIIALSANVMADVLDKCVAAGFDSYVTKPVDFKALSAAMINLLDPTGPDVASPILKQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R322</accession>
    <name>A0A3D8R322_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DUF1168-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09033</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R322"/>
    <dbReference type="OrthoDB" id="10067079at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009548">
        <property type="entry name" value="Prkrip1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13507">
        <property type="entry name" value="PRKR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13507:SF0">
        <property type="entry name" value="PRKR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06658">
        <property type="entry name" value="DUF1168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW68376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="21538" checksum="EE7594DF2D114917" modified="2019-01-16" version="1">MSEPIPESIPTSADPRSKRPIKKRAIGPVSEQASSLQALFAKPDQEIRLPSTTLVNKHLSGAPPEIVANVQGSSAGAGSGEFHVYKASRRREYERLRQMDEEVRKEKDTENFDKERKEREEKDRERTKKNREKREKMKARKSKKGGKVEDEDVGKVAGPKIVARAPARNEDGAVEDTTDVPEQVGLIIHDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7D9</accession>
    <name>A0A3D8R7D9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycoside hydrolase family 5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08293</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW69896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7D9"/>
    <dbReference type="OrthoDB" id="442731at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31263">
        <property type="entry name" value="CELLULASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31263:SF0">
        <property type="entry name" value="CELLULASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14560)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017820222" description="Glycoside hydrolase family 5 domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW69896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="438" mass="49280" checksum="1131F91A7B4336CE" modified="2019-01-16" version="1">MWFSTVSKAFLGLSILSGVTLAAQLNRALTTTALSVNGRFIVDTSGQRVKLRCLNWAGADKTKIPEGLQYQPVDATALWIFENGFNCVRLTYSMDMALDPTQTVHAAWVQAAGSTAYLPELMDTFSTAVGKNPWLQNASTLEAYSAVISALGDHNVMVIMDNHNSHASWCCSLEDGNGWWDTDAVYNSTNSRYFNTARWLSGLQFMANFSLSHSNVVGISLRNEIRRGENQDVDGTHAAWWDNIPVAAATVHAGNPDALIMIGGVDYFNDFSFLKTKPLNRSEFDNKVVYEYHTYSWGSDAFGDAYVTSSTQTNCTPFNTYLDEKVGYLLEEGKAYTGPVWMGEFGWSQVPQNDTQEEVYKTCLIEWMSNNDMDWSLWALQGSYYFRTKEVDMDETFGILNHNWTNFRYPGFLNKIGKMWITNINVEVLDGRQNLLLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7H0</accession>
    <name>A0A3D8R7H0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein s17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08386</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW69989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7H0"/>
    <dbReference type="OrthoDB" id="2336871at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053216">
        <property type="entry name" value="Appressorial_penetr-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587:SF2">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 1 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34587">
        <property type="entry name" value="VWFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017591255" description="Ribosomal protein s17" evidence="1">
        <location>
            <begin position="19"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW69989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="437" mass="42757" checksum="E0BA43F32FB94397" modified="2019-01-16" version="1">MLFPSVIAILATAGLVESRSVVHRHLDSHHALARRATASDTSLTLAADALQKGSEADGSNEVGAAEVGQALSATSTNNFINFCSGKTLTNGLQILTGSCNGIPMGDIPAKTSMVSSVITFPQTGGNSIQSDTTFNITVQMTGLVTGSFSNADATYYSAPQALSGGKVVGHTHVTVQDLGSSLNPTTALDPTKFAFFKGINTAADANGVLSATVTGGLPAGNYRVCTMASSTNHQPVLMPVAQRGTVDDCTKFTVSGSGTTPNAAANDQSGGIAAASAAAAAVAAGPGASTSAVAKAATATAAATKTAAATKTAAAKGASGGSATTSSVCSTSTGTVTVDASAATATSSATTSASTSAATSSSSTAALGGIEAPAVTNSGNSERPFAVNGNTFVGQSAAKQRSCDIQFNQCANAVNGGTASGFTLSDCSTQQTTCNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7R7</accession>
    <name>A0A3D8R7R7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_08492</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7R7"/>
    <dbReference type="OrthoDB" id="5426678at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="63"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="232"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="415"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="267"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="329"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="356"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="383"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="440"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW70095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="470" mass="50673" checksum="CBF1990681B7FD91" modified="2019-01-16" version="1">MTEVCTPLQNALEDGLQDPSNSTQYSYCTADGNAFSGANLESCISCFRETSTASYFANCNKNILFNMALTYTLLVLIALQGGCQLKPQSGELLSFDGTLFSATQIALVIPTTSTTARSHKSMGIGTIIGIAVAVVVVIVIILAVLFVCIRKRRGQNAKQGIKSVADARHGDMGISVPVHGGYISPPAKSPPAYDFITMPEFRSSKEAYSEAAEPVYLGKDNIRSVDQHYQRRQEAARQQQNEYPQYQPQAGTSAQSSPSWPLAAPQYSPQPAYNAYSPPSAASTNTAYSPRSTRSVRSARSTDKILNNIYYGKTSPSIRQPYPSPRDGTASNRSSGTTINTTISDYDPKPSPASVGISSSGLPKQNAGTLVRRASSAVRPKVHTRDLSSSRAGFHRDMKPQSAVEISGPMVAITGRFEEDEPRGRTLVGPGKYGRASGQWDKEVRVQKHGQGEVDSPVSPDEPEQWPGGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R897</accession>
    <name>A0A3D8R897_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Dead-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BP5796_08567</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R897"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17955">
        <property type="entry name" value="DEADc_DDX49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="136"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="332"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="105"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="12"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDW70170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="535" mass="58503" checksum="C808C3533CDA6EE7" modified="2019-01-16" version="1">MAPSRIKSNTRSASSPHSSDEASGSESAAKSHHSLASGDSDADSDSDSLDSNASRKRRKLSPPADEPLVPKISVPSRIKSKSKPEVSTAPQTNDGSALAPTDPDTSFESINVKPWLVRSLGAMAIRRPTGIQKGCIPEILKGRDCIGGSRTGSGKTVAFAVPILQKWAEDPFGIFALVLTPTRELALQIYEQFKAISSPQNLKAVLITGGSDMRPQATALAQRPHVVIATPGRLADHIRTSGEDTICALRRVRMVVLDEADRLLASGAVGSMLPDVEECLSVLPPAAKRQTLLFTATITPEVRALKELPQTPGKPPVYVCEVDTQRMAIPVSLNQMYLQIPVTHREHYLHMFLLTDVNLPKSVIIFCNRTATADYLTHLLRLLEHRVTALHSKLPQRQRIDNLGRFRAAAARILVATDVAARGLDIPEVGLVVNYDIPRDPDDYIHRVGRTARAGRKGDAVTFVGQRDVELVLAIEARVGRPLKPWEEEGVNLETRVLRESLKLVGEKKREAMLEIEEGREVGGKRKRGMRKLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8E1</accession>
    <name>A0A3D8R8E1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_08643</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8E1"/>
    <dbReference type="OrthoDB" id="4502894at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW70246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="144" mass="16198" checksum="C1923F6FF3E0FABF" modified="2019-01-16" version="1">MAAMTFPVSLLARFEVCLSPDTFPGREADAPKTLYIYLGIASFIGLISGSILYFSSTVLVSLFHLESVPEDKGRTAASVRAAREQKKLEEAWQSSSLNSEQTTRWKADTSMQKWLEKDAERRRDERGILGQTILEEDDDSEDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCE1</accession>
    <name>A0A3D8RCE1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">1,3-beta-glucanosyltransferase</fullName>
            <ecNumber evidence="9">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_07743</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cell membrane</location>
            <topology evidence="1 9">Lipid-anchor</topology>
            <topology evidence="1 9">GPI-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the glycosyl hydrolase 72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="9"/>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RCE1"/>
    <dbReference type="OrthoDB" id="421038at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042124">
        <property type="term" value="F:1,3-beta-glucanosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071970">
        <property type="term" value="P:fungal-type cell wall (1-&gt;3)-beta-D-glucan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031505">
        <property type="term" value="P:fungal-type cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004886">
        <property type="entry name" value="Glucanosyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31468:SF5">
        <property type="entry name" value="1,3-BETA-GLUCANOSYLTRANSFERASE GAS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03198">
        <property type="entry name" value="Glyco_hydro_72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 9" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="8 9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017495445" description="1,3-beta-glucanosyltransferase" evidence="9">
        <location>
            <begin position="19"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="373"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="392"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="427"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW71709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="471" mass="49558" checksum="FCA8FD94A5CD6C4B" modified="2019-01-16" version="1">MKTAAVFAALAATVGALATRTESLSPRQATTGDLPIVTVRGNAFFAGQERFYIRGVAYQPGGAADAADPLVDIPSLTRDVANFKRLGINTIRVYTVDNSANHDEGMKLLADAGIYLALDANTPAFSLNRADNASLYLSYNEKYLQSLFATIDSFQGYSNLLLMINGNEVINERNNTIAAPYIKAVARDMKNYIANRGYRPIPVGYAAADVAENIVPQLEYFDCGPDGVRGDFFALNDYSWCDPSSFTVSGWDQKVKRYSNYGAPIFMAEFGCITNTREWGEIAALYSSNMTSVYSGGLAYEYSVEANGYGLVDNVNGVSTPNADFERLLAAYEATPNPSGGGGYTENTSASACPAASDDWQVETLLLPSMPSGAETFMENGAGPGPGLGDVTPSQYGGETYSESQIEMDGALPTGTVSSGRTGGSTSGSSSSSSSSAAGSAAAGRLAPDVVFLLPITIALIGVLAGMGLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCE8</accession>
    <name>A0A3D8RCE8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_07729</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RCE8"/>
    <dbReference type="OrthoDB" id="193703at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.130.10">
        <property type="entry name" value="Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain (AZUL)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032353">
        <property type="entry name" value="AZUL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042556">
        <property type="entry name" value="AZUL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056012">
        <property type="entry name" value="DUF7590"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055417">
        <property type="entry name" value="UFD1_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF15">
        <property type="entry name" value="FUSION DEGRADATION PROTEIN (UFD1), PUTATIVE (AFU_ORTHOLOGUE AFUA_4G04640)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16558">
        <property type="entry name" value="AZUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24503">
        <property type="entry name" value="DUF7590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23580">
        <property type="entry name" value="Znf_XAF1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 1" evidence="3">
        <location>
            <begin position="77"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 2" evidence="6">
        <location>
            <begin position="178"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7590" evidence="5">
        <location>
            <begin position="280"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-protein ligase E3A N-terminal zinc-binding" evidence="4">
        <location>
            <begin position="660"/>
            <end position="688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF16558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24503"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW71695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="772" mass="85303" checksum="F891B94168A99E5F" modified="2019-01-16" version="1">MAAANPVWSNTYAVAPRSSKLLPGDKILLPQSALEQLLAACTVTTTGTSRPNLAFDPFNPYSLAAARAEQSQWRDTQQQLPHPLTFRLVNAKNGNVVHAGIREFSADEGEVGLSPFLMEALGVKETERVVKLETRQGDSTGSPAAPIDFTDAQDQVVDLTKDEDETTRITVHAKQLPKGTYVRLRPLEAGYNPDDWKSLLERHLRENFTTLTNGEMLTVKGPKSEEFRFLIDKFLPEGDGICVVDTDLEVDIEALNEEQARETLKQIMSRAQKAPGTTDGSSVGGDLNIWKPSSGQVAEGDYVDYQLSSWDRAQSIEFSLQCDDGEDIDLFISPFSSHQRAKPREDEHVFGDFSNNASKKILIQPTNIELEGAESLLVSLHAPKSDSVKVPRKYVLSVKPVSIPAAGPSNKPLAVDEDTAMHGPDEEQCKNCHQWVPKRTMMLHENFCLRNNVLCPHCDGVFKKNSQEWENHWHCPYDSEFGNTSASKIKHDDVSHNARPCPNCAYEAANLKDLAAHRTSICPGKIILCQFCHLEVPQEGDPFDPSPEALISGLTAHELADGARTTECHLCSKIIRLRDMATHLKHHELEKSGRPRPAICRNVNCGRTLEGVGKNGEVGAGVRMGQGPGNDLGLCSICFGPLYVSMHDPEGRAMKRRVERRYLSQLIQGCGKAWCTNLYCKTAKAKTGKGTAAPSTKEALPLVQPLMAALNDRQAEMYFCTDEGSQKRRKLAELLAAEKVYDLEWCVAALEAEAGNLDGARQWLQNWAPKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCS3</accession>
    <name>A0A3D8RCS3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyclin-D1-binding protein 1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_07725</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RCS3"/>
    <dbReference type="OrthoDB" id="4088536at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1410.10:FF:000015">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1410.10">
        <property type="entry name" value="I/LWEQ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026907">
        <property type="entry name" value="GCIP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049317">
        <property type="entry name" value="GCIP-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492">
        <property type="entry name" value="CYCLIN D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15492:SF1">
        <property type="entry name" value="CYCLIN-D1-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13324">
        <property type="entry name" value="GCIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-D1-binding protein 1-like N-terminal" evidence="2">
        <location>
            <begin position="53"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW71691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="374" mass="40916" checksum="699917EC2CF6D660" modified="2019-01-16" version="1">MTSSTAKPGQDLESLKKTVATLSALLTQLQTTTASSDPSKTTDLNALHLAHDTASLIRAHSTKLSLLIINKPFTPSAINTVLRELIAGPLPGLASAIETCNGAKYTEAMSKELQWRAQKVFVELGALVSAIPLDGQILSDDRKNGTGATPGKGSLAATGVLWEACDAVMELKTTGISGLMIKKAEQYRDLVKDALEELKEWGEEESDSEDEDEDSESDGEADEAQDAIDKMFGSQRHIPSDDPEKIRDRLESSKKRLQLVILMFGAVIKRRLKTLPALPHPELPAELKAKSPEDPGIVSCLDEVLKVMKKIPDITDELATAFYELDGPEIDKRMDECFFNGFAAAELLVLNWEGQKDEFTTWASKFQVAMKKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCW9</accession>
    <name>A0A3D8RCW9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CIA30 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_07937</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CIA30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RCW9"/>
    <dbReference type="OrthoDB" id="426386at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010257">
        <property type="term" value="P:NADH dehydrogenase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013857">
        <property type="entry name" value="NADH-UbQ_OxRdtase-assoc_prot30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039131">
        <property type="entry name" value="NDUFAF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194">
        <property type="entry name" value="COMPLEX I INTERMEDIATE-ASSOCIATED PROTEIN 30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13194:SF19">
        <property type="entry name" value="NAD(P)-BINDING ROSSMANN-FOLD SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08547">
        <property type="entry name" value="CIA30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:ubiquinone oxidoreductase intermediate-associated protein 30" evidence="3">
        <location>
            <begin position="15"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="33"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW71903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="170" mass="19074" checksum="5B950B5F0A663C6D" modified="2019-01-16" version="1">MPSSTHTRDLFGGDQPWSSSDWTDSDDRVRGGHSQSHLTITPTQPTTAVFQGNLDIKTLGGAGFASQRTTGEDRVWDLSPYDGLLLDLDAADTKRYTVTLKDELLPKSSNGREQSTVSWEYDFTVDPNATGGLLFVPWKDFSPTYRGREKNDAKPLDLKNIKRFSLMMRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDN2</accession>
    <name>A0A3D8RDN2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter-6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_08207</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDN2"/>
    <dbReference type="OrthoDB" id="4540492at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF31">
        <property type="entry name" value="HEXOSE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="339"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="25"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW72173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="512" mass="56241" checksum="079358FD0385541A" modified="2019-01-16" version="1">MAERFERKYVSRFVPSSGLLIVILLVATSVVDSVLLGYDSSLMGSLNVMPTYSNYFSLTTATKSLNTAISYTGGAVAAFPAGFLVDWRGRREAIFWSCIITLIGAILQTCAVHIAMFILGRFIIGMGLGVAATSTPTFVAETVPQKHRAFALGLYYSCWGVGTLIASGVCYRSQYIDTTWAWRTPSLIQVVPSIACMCVLFFVPESPRWLISKDRHEEALEVLAVVNAGGDVNDPLVLLQYREIADTIAWEKTEGRQLTFKEAYTHPANRKRLIIAISFSAMVMLPGTNIITYYFGTMLEQAGITNATKQLEINIILTAWSLVIAVIGSYYADRIGRKLLCCLSLGGGIISFYLVGGLTAAYGNSSNKSGIYGTIACIFLYNATYNMGITPLTVLYPPEVLSYSIRGTGMGLYTMTTKLCGLFVTMVFPFALDAIGWKTYIINASFDILLVLFVIFFWVETQGLTLEEVDAVFDGVKHSDVPDLSVVEEGKEKFVIDAVVVEGQEQNVRKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RE17</accession>
    <name>A0A3D8RE17_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ERCC4 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BP5796_08165</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EME1/MMS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RE17"/>
    <dbReference type="OrthoDB" id="343092at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20085">
        <property type="entry name" value="XPF_nuclease_Mms4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.670:FF:000004">
        <property type="entry name" value="Crossover junction endonuclease EME1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033310">
        <property type="entry name" value="Mms4/EME1/EME2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047521">
        <property type="entry name" value="XPF_nuclease_EME1_ascomycetes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077:SF5">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MMS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21077">
        <property type="entry name" value="EME1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="15">
        <location>
            <begin position="368"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="295"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="501"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="38"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDW72131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="677" mass="75114" checksum="F5216F5510C2D348" modified="2019-01-16" version="1">MPPIVIDLLSSPELPAQLPTRPPKSSHTAIASAGTKESAGTSKTPAYNSSELTNDGWLELSSDDLPSVARIKPSKPGSASESHVLPDDNLIPFLQMQAAILPKLGAAQKGDVEFTFLSDDFDSTINLTDDPFASSPDKKRNISPIHKLPLPKVPKTSLFQRSTSNAEPSFRTATTKAKGLSRSKTVSAVMESDPIVATSSPDPFADAAKRRREKVAQNTVSGLDLDSDNVFDLTQSPKSMGSNLSLAKDPKAKTFLDPFDIETSSDLELPDIQSIVPAPRLSGDNSRTALRKYNAEKAAEEKKKKKSKERTVSDRTKQGNKEEKAIAKEEEKKRKALERLEKAAKKERQKELAKANTLRTDKKISTPEMIVDLPSCMDIKLLSHTKAVLTPLNVEHTAWESSIPVVKWRRKVENTYNTVSDLWEPCPKHIRDEKHILYIMLAQEFVDLAAGEEGKDLDALALLLQTKFQGCKTIFLIEGLMAWERKNRGIKNKEFQQAVRSIGGEEETTQSQARKRTKKDPPKYVDEEMVEEALLRLQLIHKPLIHHTNTQLETAQWIMTFTQHISTIPYRQQKDSMDTTFSMESGQVKTGEDAADTFIKMLSEIRMLTPAVAHGIARSFPTVQQLVTGLQEGGPKALEDLRKVANKDGAVTDQRIGPALSKRVHAMFLGRDTDDVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RE71</accession>
    <name>A0A3D8RE71_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_08252</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RE71"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000012">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF177">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="261"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="292"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="454"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="521"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="66"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW72218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="575" mass="60261" checksum="8D045B88AA74A0E7" modified="2019-01-16" version="1">MSLQNPELSKRSSSTSTPSTFVQEKAADSGPDAVAIHTEPNNDAASVAVADLNEAEYPQGLSFILIIMALFLCVFLTALDMTIVATAIPKITDDFHTLKDVSWYGSATLMTMGGFQSTWGKVYKYFPLKYAFLATLFIFELGSLICGVAPTSAALIVGRAIAGVGAAGIGSGAFIIIAAACVPAQRAAYTGLLGMAYSLASVIGPLIGGAFADKVSWRWCFYINLPIGGLSAFFIVLFFTTPKSVKPAVATLKEKFLQMDPVGTALALGAVISYILALQYGGQTKPWKSSTVIGLIVGCVAIIIALAIWEYFQGERAAFPPRLMSNPTVLVNALYTLFFAGGYFSVVYYLPIYFQSIQNVTPTMSGVRNLALIFAVLIGLLGSGGFITKTGIATPLMVIGGVLATIAAGLLYTLDINTTTGQWVGFQIIGGFGWGLSYMTPVTVTQALVAPEDIASATAIVLCFSTLGGAIFVAAAQAAFVNKIIAKIATSAPSVNPSQVIATGATQLRSVFTADQMPGILVAYMAGIKVVFALATAGAGAALVVSLFSNWKRIHGDKQSVVTSRDDNAKETVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RHU9</accession>
    <name>A0A3D8RHU9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">D-xylulose reductase</fullName>
            <ecNumber evidence="9">1.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Xylitol dehydrogenase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_07067</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Xylitol dehydrogenase which catalyzes the conversion of xylitol to D-xylulose. Xylose is a major component of hemicelluloses such as xylan. Most fungi utilize D-xylose via three enzymatic reactions, xylose reductase (XR), xylitol dehydrogenase (XDH), and xylulokinase, to form xylulose 5-phosphate, which enters pentose phosphate pathway.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Carbohydrate degradation; L-arabinose degradation via L-arabinitol; D-xylulose 5-phosphate from L-arabinose (fungal route): step 4/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.9" evidence="9"/>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RHU9"/>
    <dbReference type="OrthoDB" id="3941538at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046526">
        <property type="term" value="F:D-xylulose reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003939">
        <property type="term" value="F:L-iditol 2-dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006062">
        <property type="term" value="P:sorbitol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05285">
        <property type="entry name" value="sorbitol_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000068">
        <property type="entry name" value="Sorbitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045306">
        <property type="entry name" value="SDH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43161:SF9">
        <property type="entry name" value="SORBITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="12">
        <location>
            <begin position="14"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00025713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW73625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="365" mass="39440" checksum="6D25F46A7FFEAB34" modified="2019-01-16" version="1">MGSSEKLNRSFVLNSIQNVSFEDRPVPAFRDEHEVRVHIEQTGICGSDVHYWQRGRIGDFILTSPIVLGHESAGTVVEIGKAVKNLRVGDRVAIEPGTPCRYCDYCRDGQYNLCADSIFAATPPWDGTLSRYYNVASDYCYPIPDHMSMEEGAMVEPTAVAVQVTKVADVRAGQTVVVFGAGPIGVLCQAVCKAYGAKKVIGVDISQSRLDFARTYGADGVFKPSKPEAGMDPVAASEAMAEQIKKEFDLGEGADVVLECTGAEPCIQAGIFVAKKGGTYVQTGMGKENVVFPITTACIRALNIKGSIRYTTGCYPQAVALIASGQIDVKRLITNRFSFDEAEKAFELVKQGKESVIKVIIEGVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RI32</accession>
    <name>A0A3D8RI32_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_07058</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RI32"/>
    <dbReference type="OrthoDB" id="424974at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF50">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="11"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="550"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="553"/>
            <end position="563"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW73616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="646" mass="72659" checksum="AF87AE1415A84ACC" modified="2019-01-16" version="1">MASQNATPRLTCESCQARKVKCDKAMPCASCQRMKIPCVPVERHRLARGKSKAALQRARDKTNLHQHHPPIASTATQHRERSSSYDLASGIACVQVVQRLETAAAGCQLIGFGHKPAEHSSPSVEEFFTVEIRQKLCLVYLQRVDPVFKILHWPSLHECLVDQKPYLDYDRESPAVEALSAAVYYAAVSSLTESQSVSLLDISKAVAIKYCQANCEMALEKADLIITEDLTVLQAFILFLVASRLHDRSRRVWILLALVLRISQALSLHLDSPPFPVRPFEQEMRRRVWFAVCLLDVQSSLDQSTEAMVPAVWLQSQGPTNINDIDLRFDSSGELKTSEDFTDTTFTLMICTAQFAIRFLNASPKEEPGTLVWEERQNRVNSFRERSSTLLRGCTSTGNQFHWYTINVAEYLSAAMQLVALRPLRNLPKTGAPHVKLGSVLRLSVDILQKSQTLLNDPRGHLWYWFDGVFFEWHALAVAISEICALKEKHLVKIYWPLVEYAVGNFNLLIANSKVEKLWKPIKDLIRRTRYYLNHDLKDAVSHQDGRVVEGASSGTMHPQSNEDPLPSEVISDPAGSLNGYMGVTNSVHPILKPDATSLDEFQELTTLLEADPDPISDSAWAVWEQFVNHSPNMSDEISDWVPASD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIB2</accession>
    <name>A0A3D8RIB2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Flap endonuclease 1</fullName>
            <shortName evidence="15">FEN-1</shortName>
            <ecNumber evidence="15">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BP5796_07138</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="15">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
            <location evidence="15">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="15">Nucleus</location>
            <location evidence="15">Nucleoplasm</location>
        </subcellularLocation>
        <text evidence="15">Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14 15">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="15"/>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIB2"/>
    <dbReference type="OrthoDB" id="1937206at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09907">
        <property type="entry name" value="H3TH_FEN1-Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09867">
        <property type="entry name" value="PIN_FEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000009">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000003">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12 15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 15" id="KW-0235">DNA replication</keyword>
    <keyword evidence="6 15 19" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9 15" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="8 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 15" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4 15" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13 15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 15" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="18">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="17">
        <location>
            <begin position="164"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="378"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="378"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00034726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RDW73696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="413" mass="46945" checksum="204049B06885CAD2" modified="2019-01-16" version="1">MGIKQLFSIIRDEAPDAVKEGEIKNQFGRKVAITRRMRMHTNSIQISNLTLARSMSIYSFLIAVRSGGEMLTNEDGETTSHLMGMFYRTLRIVDNGIKPVYVFDGAPPKLKSGELAKRFQRKAEATEGLEEAKETGTAEEVEKFSRRTVRVTREHNAECQRLLKLMGVPYIIAPTEAEAQCAVLARAGKVYAAASEDMDTLCFDSPVLLRHLTFSEQRKEPIQEIHLDKVLSGLNMDRKQFVDLCILLGCDYLDPIPKVGPNTALKLIREHGSLEKVVEWIKSDKKEKYAIPEDWPYADARELFFKPDVRPADHAECEFKWEAPDVEGLVQFLVTEKGFSEDRVRTAAAKLTKNLKSSQQARLEGFFKPIPKTEEEIKSLKRKNEEKNEAKKKKLKEEKKEKKTAKARPRGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIM5</accession>
    <name>A0A3D8RIM5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HCP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_07186</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIM5"/>
    <dbReference type="OrthoDB" id="4095816at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051726">
        <property type="entry name" value="Chitin_Synth_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430:SF2">
        <property type="entry name" value="CHITIN SYNTHASE REGULATORY FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46430">
        <property type="entry name" value="PROTEIN SKT5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="608"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="698"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="767"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="851"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="868"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="895"/>
            <end position="914"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW73744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="937" mass="102963" checksum="AF401FE09BEA25C2" modified="2019-01-16" version="1">MAYHSHPPRAPTAQQHQQYGYARHYANPMRAATLPPPRAAASSQDFYPPALQRKPTLPVIEQSDQPSYVSRQQLPGPPLSAPQYNNMSSHEYQKAQLGATFYPGGYDDFQMPELVSPSPQRIMPEVPSNMQESLAHLELEARNPQSRVSSTSSSYFSQSTLEPAPLQPRGGTPSNMGAAGPQYTASYDHTNASAYQNLNGMSKQYVIPQHPPESPNFSPFPKPRDAGPNVPLSDEDKEEVLERARSLVLKSNDPEMQLAWAQDALAWVEVANQNHLRLAESEQSSRSVTPKVEHQLRVDAINIVVFLAEQQHPRAEFIKSMWLEFGKFGYRVDKKEAFLGYRRAADKGYARAEYRIGMQYESTNDPVKAIKHYNIGVLLKDSASSYRLGMMTLLGQHNQPQDYEEGLRLIRFAAETADENAPQGAYVYGMLLARELPNITIPDAYLPFDTTGAKLYIEKAAYLGFAKAQTKMAQAYELCQLGCDFDAALSLHYNALAARQGEAEADMAISKWFLCGQEGIFEKNEELAFTYAKRAAQAKMSTAEFAMGYFYEIGMYVKPDLQEAQAWYKKASDHGNKDALGRIDSISRNKALSKSDHEQIAISRIKSTHGSMRGKRPDRLKQRNAPMASMSEERVDMPSDQMNSYVRPQSAAPPVQRPVSAAPYPEDDMVHPHSAGHAPLSPYYKPNLRASSGIGPPMADRPSSAFGVRPPAHSNTTPYPANTLRPMEQPMRPSTSQGNMPLPAGRGVPTANRVPSPNWEPQMPGNFVQTPSRTPVASNPTAPPASGAKLQKQPQGNMMKPQPPMPGYGAELGGRKPLPGQATVPPKINPAPYEGKTSATPSSQRPDRVDSMSVPSVQLQSPPPRFDSAQSYRSEPSRASQRPAQQAMSSQDPRASTMSSATTSTTTSTASKASKGPSTFEEMGIPAQKTEGDCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJT3</accession>
    <name>A0A3D8RJT3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_07658</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJT3"/>
    <dbReference type="OrthoDB" id="1028014at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF292">
        <property type="entry name" value="SET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="34"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW74216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="350" mass="39664" checksum="200DD90B6A8940DD" modified="2019-01-16" version="1">MSYIPSPTALVFTKTSQPIILSLEPDRPNFYVHPDVYLTTDDELKGTGTVSKADVQKGTLLFIDKPYSIIPTAAPGSTTPYSHPLCSRLQCSQEVDLSSASTKSCHCITEVVWCNAECQALGKAEHDFECSWLKTHSKSIRQEIIEPDFFSLWLIVRTLAQRDMELSSPPTSTTGPNGTFPCDWNVIRGLRSNEDELQPLKVQGWRSLAERYLVGEHSMLRHSLNVDEMLTLMCQVEINHYDLWTQLIGVYPLPAEPVERAESCFAYTMYLRTPFLNHSCDPSLMHQPDGNGRMVFHATRFIPAGEEFSIAYFDLAEPKYADVKERRAYLEDEFCFTCVCPRCLHESGEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJU5</accession>
    <name>A0A3D8RJU5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_07650</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJU5"/>
    <dbReference type="OrthoDB" id="2269373at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF85">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="19"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="156"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="638"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="646"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW74208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="778" mass="86608" checksum="872E861719C5667C" modified="2019-01-16" version="1">MATAPSAHSSSIPSQSTFACVRCAERKVKCDRQRPCSACVNHKVDCVFQPPRTPQRSRRRIKDQILTDRLRYYETLLRDQGINPNKLSDTRGSDAQHRPNESVIVVPRESHVSTPSAVESEARESVSKTQVIHGQGRAMFVDNSLWSRVVEEFHDPDDPLDDSVTDSSDAEASDDEFGFVLGNRSKSNPKSRHPPPQGILQLWQIFVENIDPLTKVLHVPTVQPAIEKAASNIGAIPRSFEALMFAIYGTAVMSLNDDECAQKLGESRKTLLSRYTTATKAALSRARFMGTTNLVVLQALVLHLLYVRDIDEPRAVWSLTGVAVRIAQGMGLDRDGVALGLSPFESEMRRRIWWMLKTHDFRIAELCGRPKFLDLDMGPDGTKCPTNINDDQLYPSMPSLLADSNGLTDMTFVALRYELASFATGRVAKLRQEGNSPSQWEQDLASKGSKGLSDETFRKIEGLLEMKYLRYCDPSQPLHLITMLMARSSMNTIRFMTHHPRRWASLEQTPPSERQSVWEVSIKLLEQNNMLQADPHLKQFAWHAAFARQWHAFIHVLDTLRAQPLMADAEKAWELIGSTYKNNPALIFNTRKPIHVAVGSLCLKAYSARACALRPHGNIGPPPTPEFILQLRRQRGVAKGKKHARDAKNRQGKKPDIPGPAKTGDMGAQPDAGVAYSSNMLGTTHLHLNLTSQPLVVAPYESGATGDDSFWVMNGFDDSQIGSFNDGIDVDLDLMLAQDHKPGDHASQSITWEQWDTWLAESNAMPPLLSGRDLGAGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RNU6</accession>
    <name>A0A3D8RNU6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_06451</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RNU6"/>
    <dbReference type="OrthoDB" id="5204190at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="192"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="298"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="402"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="18"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="99"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="367"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="474"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="545"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="114"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="124"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="496"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW75630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="564" mass="59580" checksum="34A664D2A729F965" modified="2019-01-16" version="1">MAEQPSITSILAALAAQRSNTAPLQSAPPTAYPAAPSTQPQNPYGNPGGYALPQPTNSGSVDLSNIKPVSSGSVSIADAIAKAKAIAAEKGVAYDRAPSYGSADLRASGGHPYRTSRSRSRSPQRRDNFRDNFNPYRDERRGGDRAPPGRDYRERSFSPGPRSRGAAGTFSPPRGTGAYNARERSPVRGGEENNVESISIESNLVGLIIGRQGENLRRVEGETGCRVQFITGPDETGPYRQCKITGTRAQRTAAKAEIKRIIDDSGMAGSARAVLDRASRDAVPVARGVSHQPTLRDGEDSMQIMVPDRTVGLIIGRGGETIRDLQERSGCHVNIVGESKSVNGLRPVNLIGSREAATRAKDLIMEIVESDSKSQGGKDRPPVQREAGRDAGFGTSAGGGGDKITDSIYVPSEAVGMIIGKGGETIKEMQSTTGCKINVSPSSGPGEVEREIGLVGSREAIAAAKRAIEDKVEAVQAKNGGGRSRAPQNDYGGDRAYSQQSYSQPQPQTLPQQAQAAPQANAEDPYAAYGGYQAYLQMWYAAMAQQQQAGQQPGSDASKPPGTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPN4</accession>
    <name>A0A3D8RPN4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_06844</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPN4"/>
    <dbReference type="OrthoDB" id="5226580at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF10">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="82"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="99"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW76023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="614" mass="68850" checksum="94566318A9C46A8D" modified="2019-01-16" version="1">MDAVYSSSKAKACANCVKAKSKCLVSIETGSKCERCCRLHKECIMPTLLRKKRPRQSRSAQLAQLEQKLDGLVSILGVTDKARPQGPVLTPNSEPDLISPSNTFQKQGPPQQSSLHASLASHDGTDVDPSPLAQPQNSDSSGTKPQESPDALLSIFRKDLARQMPFVIISPTMTAQELCQKRPFLYKAVMMAASYTDVARQLELSAEIMRYLAENLLLRGNKTLDILQGLLVYIFWQVKLRYQCHFYTRTMQLNNLVALMGSLMVDLGINKKAKPGHTHDTLADEINCELTEVIGANQGLNTMEEGRAVLGCFYLSSVICSSISKLDAIRYTPIIKDCYEAVLTCGGQQERDLFLVQIVKLQCLVEKIRHSSVWTDIANGKSNTLVAPIGFWVQSFWSELQTFKKELPPELADDPIIMRSYTSAEIRLFEIGFHMEPSFSAFTNDSLQRLDVLHACFRAVTRFFEIFLQIPSTSPFAISIINCAQMVRAIAILSKLSLFEADGWDLQYVRRTTDLSKILERLASRMEITSQTYGYGDSIAAVGWAGGIGRTRQLKIWYDKRIAEEAKAVSFQAPSNSDCRPAEEIDFQNQDSWAMNADFYADFWTELPGDWDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RV75</accession>
    <name>A0A3D8RV75_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_05728</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW77876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RV75"/>
    <dbReference type="OrthoDB" id="3830579at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW77876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="232" mass="25635" checksum="B60A44FE4AAF8111" modified="2019-01-16" version="1">MAPITEFISIELDPSIDPEDPMSPGSMIWKQAISELASQPGCLGLQWARRVESPEWLVIKIDWNTWEDYAAPDGHKHFEELMAPLYTNKPLISDAASYEPFTASEVLSAAPTIEILTLLTPSSWSSEQTAALELAGVKVSTSTLSRPDGVKAVTHAWLMSEVDHPDSPTGKAKALRFLLAWPSLQVHHEVMATDEFKKNMGPIKAKCLPPVYGRGMFHAEFSTANSLSYLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVA6</accession>
    <name>A0A3D8RVA6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative voltage-gated shaker-like K+ channel subunit beta</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_05758</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW77906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVA6"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150:SF6">
        <property type="entry name" value="VIC POTASSIUM ION CHANNEL, BETA SUBUNIT (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="26"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW77906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="351" mass="39156" checksum="7E0C199E2E6AFBAC" modified="2019-01-16" version="1">MAWPEPRNTGMLYRRVGNSGLHVSVLGLGGWLTFGGHVENERTFACMKQAYDCGINFFDTAESYAGGQSEVMMGKAIKKYGWNRNDVVITTKLNYGGANGEVLINNHGLSRKHIIEGLKASLKRLDLEYVDIVYAHRPDRLTPMEETVRGFNYVINQGLAFYWGTSEWAADEIAEACGIAKELGLIAPIVEQPLYNILDRKKVEGEFQRLYPRFGLGLTTFSPIKMGLLSGKYNDAVNGPPAGSRFSESQDKFAEFMRDNYGNEEWKSNIAKVSRLKPIADRLNVTQSQLALAWCLKNPNVSSVITGASKPEQIVENVQALKILDLLTEDVMKEIDVAVDGHISRDPDRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVE4</accession>
    <name>A0A3D8RVE4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNL-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_05894</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVE4"/>
    <dbReference type="OrthoDB" id="512667at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024158">
        <property type="entry name" value="Mt_import_TIM15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007853">
        <property type="entry name" value="Znf_DNL-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922:SF13">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05180">
        <property type="entry name" value="zf-DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51501">
        <property type="entry name" value="ZF_DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNL-type" evidence="6">
        <location>
            <begin position="91"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="45"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="180"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="188"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW78042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="218" mass="24332" checksum="99D787E8366F5D0C" modified="2019-01-16" version="1">MPPLQIHLPLLRGISRRSLQTSRPSQICRTVPGFSRSIRQFQSTTTSFYSATRPSSTEPSKASPINSNSHKPKPISLPSAESETSTDAPKTPPPSYELTFTCTPCSTRSKHTISKHGYHFGSVLVTCPECRNRHVISDHLNIFGDRNLTIEDLMKEQGQIVKKGTLSEDGDVEFWADGSMSKRAQKWKPHEREEKLDGEPRISRVPGETFGRKSAEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVP3</accession>
    <name>A0A3D8RVP3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Fatty acid desaturase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_05917</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVP3"/>
    <dbReference type="OrthoDB" id="1461976at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03507">
        <property type="entry name" value="Delta12-FADS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005804">
        <property type="entry name" value="FA_desaturase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012171">
        <property type="entry name" value="Fatty_acid_desaturase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32100">
        <property type="entry name" value="OMEGA-6 FATTY ACID DESATURASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00487">
        <property type="entry name" value="FA_desaturase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="domain" description="Fatty acid desaturase" evidence="2">
        <location>
            <begin position="84"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW78065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="401" mass="46423" checksum="E53A22C76167A68A" modified="2019-01-16" version="1">MAPTSVMVGMQEKEATILLETSEFTPPEYTMKQIHDAIPVHCFKPNTLLSFSYILRDFLYVLVLGSIAATQIPKLESPTFRNLAWAAYAFCQGLVFTGLWELAHECGHGALSKKRWFNHSMGMLMHSFLFVPYHSWRFTHSHHHKSTNNLEQDIAFVPDLKKDYEAKRDARGSLEWGDLIEDMPIVTLVWLFFHQLIAFPLYLTINNFALSWIRDAPWWKRSHFYFGPGGPLFKDANRNDIIISDLGIATAAFVLWVAVHCFGAKNVMLLYGFPYLWTNHWILTITYLQHTSSALPYYSSPSWTFLRGAASTIDRDFGFIGRHLFHGAIETHVLHHHASRIPFYHATEATAAMRQVMGTHYQSNFKTNYLLAFWRNLRNCRYVVERKEGSGIWFFDSPKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVT8</accession>
    <name>A0A3D8RVT8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_05948</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVT8"/>
    <dbReference type="OrthoDB" id="3641178at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="316"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="378"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="380"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW78096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="525" mass="58659" checksum="A3E1B3C11AF2542D" modified="2019-01-16" version="1">MAGQSPLQNSRVSLSARRIYFNPFHALHAKRADRKAQEFASTIASFPAVPSSSMLHPSTDNTNDDGPFQQQYRCPVRRGKTTGTGMERLIPLVLGSSASSVSSRRDSAILNINISRSSSVGAESSPVILLPIIPSPRTLTYPNSTTPLVPEAISLKSDQRLPPPPRPKPVTDLIIMPTTRKEWRSVMDEVRMLYLRRQHKQCSTRCEQILSGIEDPYRTHPLYLIYLSFYAGTCIELTARAMHANSSEKIPLLRKSLKYYEKAESHMEYATFSADPTIISASQNRDLLSQTTSDSSSARSSIDSVFSQDSTACSDALLSPNSPTSSIFSSGKEDESIPKPSSQKPQTCKTPREFEPLPLKVKKTVSFSLPSGLSRKICKRSSTSEDPIMSSASNESLNPSASSPSETPSYLLSPAHARYMQHLTSLSAQLRYHQDSVRELIRSIHTSRKARRSNTPEIFHEFSRTAAVAARGGTFEEANEECKKDLQQRIERLKERGWRKERFCAEKYQELCAQAMAELDMNRWD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVZ9</accession>
    <name>A0A3D8RVZ9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_06094</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVZ9"/>
    <dbReference type="OrthoDB" id="444265at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE TOPORS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46077:SF1">
        <property type="entry name" value="TOP1 BINDING ARGININE_SERINE RICH PROTEIN, E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="22"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="201"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="247"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW78242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="256" mass="29701" checksum="10CBA8F614B2EC36" modified="2019-01-16" version="1">MTVHYEFVGQGHKSYTVPIAKAAASSGTPSTHGLRTRNIRQRRPHRPQRVYTATPTPDEALLRRRYIYQNQLYSLHVGSNRMSRFRDLTPQLFSSDAELVTRARKWIRRELQVFQFLNPDGDRDTNDRRANNAEFLLEYIVAILKTVDIQGSSGQAEEMLQEFLGRENTRLFLHELRAWLRSPYMSLADWDRNVQYNESSQRKESVGASTQQAARPAHQPRSQRGSYRGARGYPSHPQGPRYSPYSSRRDNREPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RW52</accession>
    <name>A0A3D8RW52_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_05916</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11 12">Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Vacuole membrane</location>
            <topology evidence="1 12">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the ATG22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RW52"/>
    <dbReference type="OrthoDB" id="192733at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032974">
        <property type="term" value="P:amino acid transmembrane export from vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17483">
        <property type="entry name" value="MFS_Atg22_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000645">
        <property type="entry name" value="Autophagy-related protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044738">
        <property type="entry name" value="Atg22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024671">
        <property type="entry name" value="Atg22-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050495">
        <property type="entry name" value="ATG22/LtaA_families"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23519:SF1">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11700">
        <property type="entry name" value="ATG22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 12" id="KW-0072">Autophagy</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 12" id="KW-0813">Transport</keyword>
    <keyword evidence="4 12" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="79"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="321"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="348"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="485"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="526"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="555"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="584"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="273"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="628"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="17"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="273"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW78064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="650" mass="70528" checksum="A355D730FB1C882F" modified="2019-01-16" version="1">MVRRSTSYPRSPPRRALSNSTKRSFGSHSSSFEADDERSSNSADYDIMGPDLDDALRSRSPQYEGEDTRLTSRKELSGWYAYGFAAEVFVICGIGSFIPITLEQLARENGVLLSDRTTPCGSSSRPLLPPNSEISADAVKDLGQCIVRVLGLEINTASFAMYTFSISVLVQALLVVSISCAADHGNYRKRLLLLFAFGGAIATMLFLPIVPKVYLLGALLAIIANTCFGASFVLLNSFLPLIVRHHPKTQYTSPESSPEFAPTIVQEQPSLEHLGRHSEEPPTERSALLASPDSTDPLPPSQNLTSVELQLSTQISSTGVGIGYCAGLFVQIVAIMIIVLMGSTTFSLQIVLFVVGLWWLIFTIPAALWLRPRPGPPLPSDNPDDPKSNRSWVAYIIHAWTSLFRTIKYARRLKDITLFLAAWFLLSDAIATVSGTAVLYAKTQLHMKPEALGLINVIATTAGVLGAFSWSAISRALGLRPHQTILACICIFEVIPIYGLLGYLPIVKRWGVIGLQQPWEMYPLGFVYGFVLGGLSSYCRSLFGELIPPGSEAAFYALYAITDKGSSVFGPAIVGAIVDATGEIRPAFWFLAALVGLPGPLLYFVNVDRGREEGKKLALVIEGFRSREESAAASGAPSYQEGEAQGSEAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RW70</accession>
    <name>A0A3D8RW70_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Enoyl-CoA hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_06100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RW70"/>
    <dbReference type="OrthoDB" id="410701at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000058">
        <property type="entry name" value="Enoyl-CoA hydratase/isomerase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.12.10">
        <property type="entry name" value="Lyase 2-enoyl-coa Hydratase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014748">
        <property type="entry name" value="Enoyl-CoA_hydra_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941">
        <property type="entry name" value="ENOYL-COA HYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11941:SF171">
        <property type="entry name" value="SD19268P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW78248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="316" mass="34179" checksum="218C2D6A16A8B7EB" modified="2019-01-16" version="1">MRLHRPIPSSLPRIVRRCYSTPSPSPVVSVHDVPAPGSGRIRILNLNRPSARNAISRQLLLELSNNIRSVASQYDSHGNEVDLAKTIEGKNDLGPVRALILASEVDSCFCAGADLKERAGFTPEETNEFLANLRNTFQALSALPIPTIAAVSSLALGGGLELALCTHLRVLASTAQVGLPETRLGIIPGAGGTYRLPALIGMSRARDLILTGRRVSAPEAYFLGIADRLVEITPEEGQDEKEVLARAKEEVLRTAVLLAGEICEGAPVAVRSALQAVHWARGEVETKMYDRVVATEDRNEALKAFKEKRRPVFTGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2D2</accession>
    <name>A0A3D8S2D2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_05155</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2D2"/>
    <dbReference type="OrthoDB" id="3563954at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW80457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="532" mass="60657" checksum="859EB9163FAC10AC" modified="2019-01-16" version="1">MPKIKSVKEGRRKGGGKRKREDTDDTIQEENPLNRNQDCSVSKGLASRNVSRPTRKHITLVETTVEKEESICQTCQENTHGLNGDLYAVTCNRCHRYDHLKCLFGGKVPKPLVFSMGLILATEKGIKEAVYHCRRCTKEPNQYTEDIARAQAEFHEKVEEINAAHKSSILAPAGTPDTESKDFSDLQQITYKLESQSNGSSRIGLATVEDFPRANPDQAGTLTRKFESIGPSRNTLAGIEEFQRVKSDYISSHIGDLEDSIAEFTEITQQRLQGSQTSFTRPLSEWEEIQAAEQYLSKSTRPPDIVLPQQLQSVTSAFRRMLKLSEEQPIEVDPRLGALDFSRVYKSFVWWFIMEFFFTPNLKPQDLAPNMRIMKATTSALMDFGYSRWPQQGEQFIRDMLLRTWEKPTFKDVIREHKPSLTKALEVFLQPLTRDFAGVHDLGGNAEDIIDSMLLLWTYINFSRGRLTEFHPAIGDSFDPTRHEATDGAFNERHQDEQRQHKVMWVVRRGFELRDISTGALLAKPLLALVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S355</accession>
    <name>A0A3D8S355_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycosyltransferase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_05394</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S355"/>
    <dbReference type="OrthoDB" id="5397682at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33604:SF3">
        <property type="entry name" value="OSJNBA0004B13.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW80696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="699" mass="78129" checksum="878B3025BD58E4F4" modified="2019-01-16" version="1">MIPPRLFAGDEELGKKDDDHKMHPKSPFGMWQSSRRAPHRRSMKRAAVVGIVLICLYYFFKNMPTDLENPRRRPSYTHGESDPAPAKSGSKTGALALVEAQDFEGPIKFYKLASTLHALVKVHGDEPRNDNVLFAAASLKSASTLLPVACEMSLKQRNNVHFAFMSRDEISMDILKAVNGVGDGCGILFHDARPDFGPRSSEFRMTVSSSAALNHIHNFMHPQVIIIDGSGNEEAFFLKGVRDRAAVINRPIIELPKDSEQSLLWITELDCVSLEAWNKVHFDILIHAQPGASGSLIRLLESLKKADYFGSPVPRLTIELPEKIDEPTRRYLENYDWPPRKIAPPGSTSQLSLHHRIPEQGLSPEESSIRFLEAFWPARAASSHILVLSPQAELSPLYFHYLKFMTLEYKHSQAQTDVNKRLLGISLDLPSTYLNDSTPFTPPPQPHTNKDTDGASPFLWQAPNSNAALYFGERWVELHEFVTNILLAERALPPPATLGQKLVSKTFPSWLEHILKLARARGYWMLYPNFDRGESMATTHNELYQIPEEFPEEAEEFARIDADTELTADPSYHLSLKHEEKPLSTGSLLKFLNGILPRVLEMPVLNWDGDEIAIMDIINNAEAYSKIFRQEIGGCGPEVPEKERFGFSARDLFCLHDVIEATENAKAAAAAGEVKTTFIATDLAAVRPTDTPVLVVGAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3F3</accession>
    <name>A0A3D8S3F3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SAC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_05520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3F3"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043813">
        <property type="term" value="F:phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043573">
        <property type="entry name" value="Fig4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45738:SF5">
        <property type="entry name" value="POLYPHOSPHOINOSITIDE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="5">
        <location>
            <begin position="277"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="809"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="889"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="34"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="809"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="832"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW80822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1039" mass="117691" checksum="F1C6A3549BF49B82" modified="2019-01-16" version="1">MAGSHDHDAAPRDLSPIPSDAGNMPSHVHFDNRSSTTDDASPTTSAMTSPLGLDIEGTDVDEQGLPKFPTLQHNLPPASDRSKRRESGFSADDGAGAESAMAEPFERISSPAPDASRSRSAEYEKVGDRGVCKMHKFSLYETSSRYYIVGADVMDRRFRILKIDRTADSGQLGIGEDDIVYNKEEMTNVLNTIEDGNKATGGLKLKSSTWGLLGFIRFTGAYYMLTITKRRQVAMIGGHAVYQVDGTELVPLTTAANSRFKADPRINNEETRFLGILNNLDLTRSFYFSYSYDITRTLQHNITVEREAVAKGMAYPHEQDYNSMFVWNSYLLEPATAALKKTYDWCLPTIHGYIDQAALSIYGRTVYITVIARRSRYFAGARFLKRGANDLGYVANDVETEQIVAEVLTTSFHAPGPRLFANPNFTSYVQHRGSIPLYWTQDNTGVTPKPPIELNLVDPFYGAAALHFDNLFERYGAPVYVLNLVKAKERTPRESKLLQEFTHAINYLNQFLPSDKKIIHKAWDMSRASKSRDQDVIGTLESIAEEVVTTTGFFHNGDGKTAVPKVQNGVARTNCIDCLDRTNAAQFVIGKRALGHQLHALGIIGDTSIDYDTDAVNLFTHMYHDHGDTIAIQYGGSQLVNTMETYRKINQWTSHSRDMVESFKRYYNNSFLDGQRQEAYNLFLGNYVFAHGQPMLWDLVTDYYLHHANPRAWSGKRRRSYIKWYTPEFLEKRTLPATVSPCGQVVGKPLDFFDDYWQEYYKPLALSSFLKVFSYMGKMNSTLRYIPLRSTQDGRYDLSPFKVRTELDQDVPERKKVKKEVTIVDPQEEEQQQQQYQHQQQQQQLQQQEEPKEEQQPADDTLSMKSGVAGNTKRISIQRWLQPIHEKDNTHHGIMKEPSAGFAGEPRPKQKLTPLDKSKAAQWTFTQVVHESLNPSVSGQEAEDYANYISHPQTLPLVVSTETPTSDIETEYLDFVNGSWQDGNLAGYATEEDLAEYAHFLTVAENPLTVADEDLPKKRYKAYRKWLLGKSLFKQQPVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3I9</accession>
    <name>A0A3D8S3I9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Snf7 family protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_05524</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3I9"/>
    <dbReference type="OrthoDB" id="10250120at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF18">
        <property type="entry name" value="SORTING PROTEIN SNF7 FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16692)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW80826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="468" mass="51331" checksum="A15E9B464C71DD21" modified="2019-01-16" version="1">MSELLDFLLENEDQFRKSRLAALYSDFRQLRTINPDGYAANVEAWRKGLASATRAGHVPSQGSTNDLLVLTVDEGLLRALETKQWGRPLALGTVIREAIGKREMMPLQEFMTATESIYQKSWNIRPWGIISWGLRQLGVVGGLSGEDALPTGRLVILANVEEASKNVSNKIGGRTSRIDRIYSKAAFQQSFENALGAKPLSQADMDVLLKFLAREKGLVAYDGATVKIKASTEASASAITIEDTSIASLKSLISDIESQTDVLTQRIEQLSLTARDAVSRKNKASALAALRSKKLAETTLSKRTATLGQLEEVFSKIEQAADQVELVRAMEGSTRVLSGLNAEVGGVERVDDVVEQLREQMSQVNEVGDVIAEVGQGTIDETEVDDELEAMESAEREKKEEEERKEKAKKKEQEAAETKRKLDALDEAAHKASAEKVEKTAEVAESGESTEALRRLSLEEKPERIPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3N8</accession>
    <name>A0A3D8S3N8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetylxylan esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_05610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3N8"/>
    <dbReference type="OrthoDB" id="2586582at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000675">
        <property type="entry name" value="Cutinase/axe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630:SF13">
        <property type="entry name" value="ACETYLXYLAN ESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33630">
        <property type="entry name" value="CUTINASE RV1984C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01083">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01110">
        <property type="entry name" value="Cutinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017666709" evidence="3">
        <location>
            <begin position="18"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW80912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="229" mass="23122" checksum="065D3677BB129A90" modified="2019-01-16" version="1">MLAKSAVFAVLFNIALAAPSALLEARACPNVHVFGARETTASAGLGSAGTVVNLILAAYSGATSEAIDYPAAGGTNSAYAASVVAGVKAVTSQVTTYAQQCPSTQIVLVGYSQGAQIIDDAMCGGGDTNQGITDTSTPISTSVASLVKAMIWMGNPRNIPGASYSVGTATADGFDPRTSGFSCSYASMIQSYCDATDPYCSDGTDAATHQGYGSEYGQAALTFVKSKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3Q6</accession>
    <name>A0A3D8S3Q6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_05631</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3Q6"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF39">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="39"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW80933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="464" mass="49838" checksum="F296ACCEA0D927A1" modified="2019-01-16" version="1">MAIDLAAIDALRSSLPNSAVLTPASDGYAESIVRWSDAAQKNAALVVLPNSSEDVSKAILFSQAQKLDLAVSGGKHSTSGSSSTEGGLLIDLSKMREVVVDAEKSTVDVQGGALWNDVDVAAGKYDLATVGGTVNHTGVGGLTLGGGYGWLTGWYGLTIDVLLEVEFVLADGSIVVCNETQNPDLFWAAKGAGACFGVATRFRFKAFEQRSTVWGGLLAFPPDKLQDVVNFANHCVEVSNGEAQMIMAYAAPPPAGQPCVVAAVYYNGVTSKAKEFFAPLLDMGPLMNDTREMPYSAVNGMLNPMSSYGDRKTQKGAVLTTPVELSFAQSIFNNFSTFVKETPDAVDSVILFEFMSFRESIKIPMTAQAFANRGEYFNVLVNARWKDVANDTKCREWARNLSKDIVSKMDKASESTGGVKEYGNYDGIGTATGQQLFGVNYDKVVSLKKRYDPQNIFNKSVSLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3T9</accession>
    <name>A0A3D8S3T9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_05624</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3T9"/>
    <dbReference type="OrthoDB" id="3358017at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF13">
        <property type="entry name" value="RTA1 DOMAIN PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="116"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW80926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="268" mass="29857" checksum="28423B5F6BDCBC98" modified="2019-01-16" version="1">MYIAQAVLVLAGPPIYSATEYNIVGRLMLYLPMHAPMNPQRVVFFFIYLGAAVEGLTAAGGAQLGSAGTDSNLLRSGATLIAVGAVLQAVVEVLFMGMIAIIQYRCARASMLTSKVHTFCIMLYGTSALVLLRCIFRIIENFSTIGLISSGNCGSTCRAILRHEWYLYAFEAAPMVLYTYWLNIIHPGKFLPSNRNIYLDLDKVERRGPGWIDNRSQWQTFMDPLDFEGILKGQPAHEKFWLRPDDWPVMGSDNTGCRTPLTMTNQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S9M8</accession>
    <name>A0A3D8S9M8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aflatoxin regulatory protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S9M8"/>
    <dbReference type="OrthoDB" id="4222821at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW83069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="41126" checksum="F6E64D4893347689" modified="2019-01-16" version="1">MSLSPVITNSSNEWSFPLALNADSTAQQATITWPNTCYPMPSNLADVDPFSADLFGDTWSATPLCQHDSTDLFDQLPPRNASPSHNTSESLLRSDNSSDFLDSPISITRSLANLNIELHECAASFPTEDGNNATSNGHRKCQEKTLFAFEELFRLTSEFLDVMEHLSAEPCQTSTTSPAAEDSQAASPNALPRVIHDQQLFTHPGLDNSPCRSRRPSLSHVDIGTVLMIMSCHHRLTEIYFSIFQMMQACIKYSLIPSCVRNGWFFVLPKCQVGAHAVLPSVQVDAKTPLAHDKSLMYMAMLTMLASQFCEKIVEMIGAPVWDARDNSKGMDRKEPSLGTGGSQGSAMSSAGLCMSVVDRTKSLQDMIDATKHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S9T9</accession>
    <name>A0A3D8S9T9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dihydropyrimidinase</fullName>
            <ecNumber evidence="6">3.5.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_04608</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>5,6-dihydrouracil + H2O = 3-(carbamoylamino)propanoate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16121"/>
            <dbReference type="ChEBI" id="CHEBI:11892"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15901"/>
            <dbReference type="EC" id="3.5.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="PTM">
        <text evidence="7">Carbamylation allows a single lysine to coordinate two divalent metal cations.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.2.2" evidence="6"/>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S9T9"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004157">
        <property type="term" value="F:dihydropyrimidinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01314">
        <property type="entry name" value="D-HYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000174">
        <property type="entry name" value="Dihydropyrimidinase-related protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011778">
        <property type="entry name" value="Hydantoinase/dihydroPyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050378">
        <property type="entry name" value="Metallo-dep_Hydrolases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02033">
        <property type="entry name" value="D-hydantoinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647:SF1">
        <property type="entry name" value="COLLAPSIN RESPONSE MEDIATOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11647">
        <property type="entry name" value="HYDRANTOINASE/DIHYDROPYRIMIDINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="8">
        <location>
            <begin position="54"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-carboxylysine" evidence="7">
        <location>
            <position position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00036696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR611778-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW83117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="502" mass="54879" checksum="C1737E292DADE9A0" modified="2019-01-16" version="1">MGFDSIVTNGVIVTATEVLSLGIEIGIKDGKISCLGTSLPRDNDTEIIDAKGAYITPGGVDSHVHFAQDNSPTGDNFTTGSRSAIAGGTTTVIAFASQLRAEESVLPCIAEYHTRAKDLSYCDYGFHLILTNPSPSIMAKEMPQIMEDGITSIKLYMTYEPMKLGDAQVLDVLMASRALGFTTMVHAENSDIISLITDRLESAGHSSPYFHAISRPQIAENEATYRIISLAELTDTPILIVHMSSEVAMKHVRKAQTRMLPIHAETCPQYLFLLSDRLRGNNEDSFSGAKCVCSPPLRHDPKDLEAMWTGIANGTFTTFSSDHAPSTYDNPGGKKKGLVNGVMRYRDIPNGVPGVETRIPLLFNHAGPEKDARLSLPRFVQLTSTDPAKLYGLDGVKGSIAPGYDADLVIWYPESELAGGVEISQKMLHHGVDYTPFESMNVKNWPRWTYLRGKKIWDRDNGGVVGDMSDGKFLKRGKGKVVVGRMGNDATGMLPGERDYWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAF4</accession>
    <name>A0A3D8SAF4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Pentacotripeptide-repeat region of PRORP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_04828</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Regulates mitochondrial small subunit maturation by controlling 15S rRNA 5'-end processing. Localizes to the 5' precursor of the 15S rRNA in a position that is subsequently occupied by mS47 in the mature yeast mtSSU. Uses structure and sequence-specific RNA recognition, binding to a single-stranded region of the precursor and specifically recognizing bases -6 to -1. The exchange of Ccm1 for mS47 is coupled to the irreversible removal of precursor rRNA that is accompanied by conformational changes of the mitoribosomal proteins uS5m and mS26. These conformational changes signal completion of 5'-end rRNA processing through protection of the mature 5'-end of the 15S rRNA and stabilization of mS47. The removal of the 5' precursor together with the dissociation of Ccm1 may be catalyzed by the 5'-3' exoribonuclease Pet127. Involved in the specific removal of group I introns in mitochondrial encoded transcripts.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Binds to mitochondrial small subunit 15S rRNA.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAF4"/>
    <dbReference type="OrthoDB" id="185373at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002885">
        <property type="entry name" value="PPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00756">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447">
        <property type="entry name" value="OS03G0856100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47447:SF17">
        <property type="entry name" value="OS12G0638900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01535">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13041">
        <property type="entry name" value="PPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13812">
        <property type="entry name" value="PPR_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51375">
        <property type="entry name" value="PPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="496"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="repeat" description="PPR" evidence="5">
        <location>
            <begin position="626"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="34"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="41"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00044511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW83337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="871" mass="98165" checksum="CD82410256C65523" modified="2019-01-16" version="1">MTTPHICAACRRSISRLRSNNTLQWQSRATFISIATPTTGENDKTKDGSKKLPQGRRAKEEQWGQARRGKRNKYPGFSPEAGAQLELLFKESVTATPSADPATSKLVPQPITPFHSYKDIDTLNQMIQDGPHVLPAAWKFFEEHYGPESIEKRPGGKAPRPTFLMHSFRRLLNNLIQAKRIDPFSTELPTVTEITRVCQGIQMLTCQDWAQLMYGLLEGLTRAAQSELPEYTHEVDEHLIKDLLGSWNIICRRTPLAPGRSLKGPYFNWSQVPRFSCEELDRAIAKHGNVYAFGYLVPRIRSRILDGVALVALASYAHLNNETRIASGVAAGADPLMAAFSRVISVVEVKESLLDSGSSPPPNLRNFVLKEWDSLKKKASATALITSPEDAASAAVTETSAETRSAFLHLRPARDDSQYMKKRVEEALRGKDFKAVEELWRRVQSWPANPEPDQSKPSHVTLPLCNYFIHAYMCLHQPHRAIDIWNFMIQKGLSPTLETWDSMLNGCRIARNWTGLEDVWGKMVSSGIQPDVVCWTTRIGGLLSCNKIEYGLEALNEMGRMWIAAGQKQYGQEKTISDLYNKKVSGAVKPSIETVNAAISVLLQRNREDLVHQTLNWAAKFGIDPDIVTYNTLLWRLFRQGRTPEAMDILKSMSEAGLKADVATFTTMLEETFRNTENKTPQEQTRLIADTFKGMEAAGVKANLHTYGKIIHQLLQGDTSDITSVNMVLERMRKERLRPSGYIYTTLVGYYFRQKPPDLDAVKQILESVRQDEGSVDNIFWDRVMEGYAETGDTPAAMKILAKKQDIGSRASWFTLRVLLLALAENQEWDVAKAMVRSIKDEHWSKHDLESGAPDAHKFWRSATEMQLLEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SB46</accession>
    <name>A0A3D8SB46_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">nitrilase</fullName>
            <ecNumber evidence="4">3.5.5.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_05011</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a nitrile + 2 H2O = a carboxylate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:21724"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:18379"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="EC" id="3.5.5.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.5.1" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SB46"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016836">
        <property type="term" value="F:hydro-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000257">
        <property type="term" value="F:nitrilase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000011">
        <property type="entry name" value="Cyanide hydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000132">
        <property type="entry name" value="Nitrilase/CN_hydratase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF14">
        <property type="entry name" value="ARYLACETONITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00920">
        <property type="entry name" value="NITRIL_CHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00921">
        <property type="entry name" value="NITRIL_CHT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="6">
        <location>
            <begin position="6"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00036406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00039045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW83520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="326" mass="35616" checksum="6E603A5E4143297E" modified="2019-01-16" version="1">MVQSIVRVAVTQAEPAWLDLQAAVAKTCVLITEAAGNGAQLITFPECWIPGYPCWIWTRLVDFDMNVEYVKNSLKITSSEMDTIRDCAAKNNIAVSLGFSENDNNSVYIAQALIGPDGEISMRRRKMKPTHMERTVFGDASGDCLTSVADTPFGRVGALACWEHIQPLLKFHTISQKEDIHVSAWPSVTPHTGGPDFWSMSAEGCQNLSRTYAIESQAFVLHTTALITAAGVDRMGTSKGALMSSPGGGSSAIFGPDGRRLTEPVDDTTETILYADLDLDSCIKAKLFADGLGHYSRPDLMWLTVDKEVKKVVKGQENDNVKHEED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SGA5</accession>
    <name>A0A3D8SGA5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxymuconolactone decarboxylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_03685</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SGA5"/>
    <dbReference type="OrthoDB" id="2567457at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1290.10">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34846:SF11">
        <property type="entry name" value="4-CARBOXYMUCONOLACTONE DECARBOXYLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11590)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW85360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22278" checksum="DD26FDA10C101798" modified="2019-01-16" version="1">MSGPRYPAIPPEKLTPEQQVFHDEMKEKIRNGMGSTFTLEGKDGGLLGPLSIMMYTPQYSTHTMRLNKEVLNLPALEPLVTEVAILATQGHYTGSFGGGFLTYSHSRIVASQGLLTEEQMKKITRGEKPTGLGEKGDVAFDLAMRLVKGGKPLEQDLWERANAILGKEQTLHVIQLVAYYSLHGVTLNAGIIGAPEGERIWKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SGG1</accession>
    <name>A0A3D8SGG1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_03688</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SGG1"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000134">
        <property type="entry name" value="MFS sugar transporter protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF64">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="284"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="326"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="36"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW85363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="529" mass="57631" checksum="F26DD0FFDC731D14" modified="2019-01-16" version="1">MNFLYSQPANQAWAKYANNADPKWWKDRGLTMSMLVIFAIWLTQSTDGYDKSLTSSIQSMTAWKTAMGKPNAHSLGLINASLSMGGLVFAVPASYIEDWFGRRAGIFFGMVLLLAGSIIQSAANSVGVFTGGRVLVGAGIAAAVTCAPILCQEISHPRMRGQVASLYNVMFNFGAIFVTWIAYGTAYLGNNQWAWRIPTIGQNVPCLLVLLALPWIPESPRWLVQKGKVDEAHQILAKYHANGKMDDELVLFELSEIREAVQLEKDSRLSWVQCFATPGNRKRFLLLTLVSIVTNWNGKAIVTYYFSSVLKLIGITQQTHVTGFNAGIQVFNLVATLIGAGVCESWGRRRVWLSAFGIMVVANVIQTACSAAYAHHASSGAGIGTLVGVFLYSFGFDLACNPLLFTYEVEIMTLGLRSKGLAWAVTLNNGQGVAISYANSVGLAALGWKFYLVYLALLIVFIVIIYFFFPETSGKTLEEVAVMFDGEDSLLYIRNHAEMDMSAAGVGSAGVGYISQVVGGNDTKLTEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SGP3</accession>
    <name>A0A3D8SGP3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03676</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SGP3"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF170">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="97"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW85351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="532" mass="57643" checksum="39CC1068CE627095" modified="2019-01-16" version="1">MSSTLAPSTVSERNPITEKDVISTLDSLGLKPNPKDIDDFTSLLTGIWEVWDKVNQMEDYIPEVDEERFPRKNVHRPEGQANAENAWAWKCEVRDVTDQSKGGLLEGKTVNLKDNIALKGVPCLLGTEVFTDYIPNTDATVAKRVLEAGGTINGKAVCENMSMWGISCSAATGPMNNPWAEGFSAGGSSSGTTVLVAKGLSWGGIGGDQGGSIRIPAGMSGLVGLKPTTGLVPYTGIASLEPVIDSTGPMTRTVLDNALLLQAIAGVDGIDDRQQAGCPFPADVPDYRTLTTQGVAGMRIGILMESFDQPLSDTRVSELVMKAAKSLESLGCTVEEVSVPMHKHAPDIWAVPGRLSAYASQMGKNCGRRGYCMNDLTEKMLPINQEKFDKMWAGYSNTVINGKWGWDNLPPTLMGKATNLIRKLRDNYYEALDKYDVLILPTVPFLAPKLPSPNAGIRDVMVNSAGVSLNTSAFNLTGLPALSLPIGFLPSLVEPHPKLPVGMQIVSKFYHEPIIYRVAYAWEQNFDWKTFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SGT0</accession>
    <name>A0A3D8SGT0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BP5796_03884</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SGT0"/>
    <dbReference type="OrthoDB" id="2015534at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009584">
        <property type="term" value="P:detection of visible light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000160">
        <property type="term" value="P:phosphorelay signal transduction system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013654">
        <property type="entry name" value="PAS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016132">
        <property type="entry name" value="Phyto_chromo_attachment"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001294">
        <property type="entry name" value="Phytochrome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013515">
        <property type="entry name" value="Phytochrome_cen-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043150">
        <property type="entry name" value="Phytochrome_PHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43065:SF10">
        <property type="entry name" value="PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43065">
        <property type="entry name" value="SENSOR HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08446">
        <property type="entry name" value="PAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00360">
        <property type="entry name" value="PHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01033">
        <property type="entry name" value="PHYTOCHROME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00065">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50046">
        <property type="entry name" value="PHYTOCHROME_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 11" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="1" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="PAS" evidence="16">
        <location>
            <begin position="160"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Phytochrome chromophore attachment site" evidence="13">
        <location>
            <begin position="324"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="14">
        <location>
            <begin position="658"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="15">
        <location>
            <begin position="924"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="54"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="829"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="874"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="21"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="831"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="874"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="903"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="11">
        <location>
            <position position="976"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDW85559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1070" mass="120339" checksum="9E02EE449B028D62" modified="2019-01-16" version="1">MRQLLSRKSNTPLHDEETKSSRPSVSVPQNNFEWLPDHSSKSFADIIERFPSTKSGGWKLHSDHQGALTNDGRQTPRRSRSDSGSRLERDERKISERSQLFPTRMGPPKVLTGGMDEKSRLTYRRCEDEPIHTPGAVQNFGALVAVKYGEHGLLEVRITSENSRKILGYGPEQLFELPSFLDILQDEIREEMVARINHAIREGSTEDTRLDIFQVVLTYPFEPDTRLWCALHLAPGSEGLVICEFEEYLDAFRRDAEIAKMLPVKPVHLGYEVPEDELKKSTVSASKPLLGVEITRQKQKQQFSTLDLFNIMNQAQKQIVGCKSLHATYEVVVGLISELTGFHRVMFYRFDPQKHGLVEAELLDPRASTDAYRGLHFPASDIPKQARELYKLNRIRLLHNREADTARLVCRSDADFEQPLDLTHAYLRAMSPAHHHYLENIGVRSTMSISIVIDSDLWGLIACHGYGELGMRVSLPIRELCRNIGDCTAVQIQRLLTVQRMEARRLPVANPYIEDPADVLALVNADFAMLSIDDTARPIGKPEPYDEALAITSYLQSCRFTQVRSSQNIKADFPGLSYPPGLSSICGLLLVPLSFGDGNDFLVFFRKGQQKQMTWAGNPYEKKYRPGTDYLEPRASFQRWSETVAGMSPEWTVDQPLRVLQALQKDGQQNSLDLSISVDEKLAIMVKGNRSRFEHLIVYFTSNAFKKATSAIVEIRLVRNKEDISIIELKFQDGGPAMSECELDDTFNAFEQGQRHVKCQNEINGEIGDDIGVITRYVRALQGQIQVTSEMLKGTTFTVELRLEHAPSSDGSRARKFRNLFLSSNGFKGVSSTASMPPSMKPSKPFSTEMQRKTETTTPSEVIFTATTIGTTSQPFHRIASSGSSDHAPNIDDGAKGEPSLQSPDMVSRDSPSSPSQASMHNLNVLIAEDDPISLRALDERLSQWGHTVEIASNGQECYDRFMALSPSGVDVILMDLKMPSVDGTFSTKLIRFMETESMNRNKYNGQEQQSPKPRVPIIAVSASLFDGWLMKPIDFRRLDLLLEGVKTPKSRREALYTPGQWDKGGWFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SGW8</accession>
    <name>A0A3D8SGW8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">GPI transamidase component Gpi16-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_03719</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SGW8"/>
    <dbReference type="OrthoDB" id="331263at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007245">
        <property type="entry name" value="PIG-T"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959:SF11">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04113">
        <property type="entry name" value="Gpi16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017618872" evidence="2">
        <location>
            <begin position="22"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="518"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW85394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="582" mass="65583" checksum="2E290F68B0028041" modified="2019-01-16" version="1">MPQLIKYLLLLICLGFGIVSASSDYSEQLLLRPLHPSSLLASFNFQSNASWESFEQQNFRYFPRSLGQILQFANTRELHLRFSLGRWDAENWGARPWGGAREGGTGVELWAWVEADTDEEADGRWLTLTNALSGLFCASLNFIDSTRTTRPVMSFQPSNDHSNATLANLHLLHGTLPREVVCTENLTPFLKLLPCKGKAGISSLLDGHKLFDASWQSMSIDVRPICPEGPGDCQIQITQTIDMVLDIQRSKRPRDNPIPRPVPEHELRCDTTKPYHSGDTCYPLDIAQDENWSMTEIFGHAMKGSCPLMDEGATPVCINVPHARDVFTSGGAVERKDESGFMRCFELAAEQDFEVVLPSQDLPERAPLEQPLLYAERSFTGYGQERGGVQAILTNPSTTEAVDFVYMESLPWFMKVYLHTLKAKINGVDGDVIQEMYYRPAQDRKRGTQLEIRMRIPQNSTVVLNYDFEKAILRYTEYPPDANRGFDIAAAVITIGNVSIRTTSLLLSLPTPDFSMPYNVIILTSTVMALAFGMVFNLLVRRFVGADEAEQWDIRAIRLRLLAQLRTIIGRFKKEQKVVKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHF5</accession>
    <name>A0A3D8SHF5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04104</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHF5"/>
    <dbReference type="OrthoDB" id="3498215at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW85779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="371" mass="40561" checksum="6CA3B3DDFF77F8B4" modified="2019-01-16" version="1">MGRPRKRKLNEAEERATRTDPGLEMDSVPVFSDNAGGYDNTGAYTEPYFATDTAVLPQGLPPNTKSDEGRAIWSFGEMKIPTGPPIQFGQIDFGDNDIEHLASPDNIIPTDATPTLSTEHSTVTSDSDNSFSQNVSCSCLASMYLALASLQQLPSDIKTALYTVRSACSTAQRSVWCLQCGSVMLNEKTPPIESFQNTMLLGTILPVIANGYRKLLEMIDNHTKAATAAGQTMAFELNDYGGIGYDSNDSSWQTGCSQDICSNRSMQPAEWRSTVRALLRMDIYGHEQGGFKCKGLRDIVDEMETRQQTRHLLLDAHIASGTSDWGRHEVFKGGHFGSGQDSPKLCLGEKTATCLEIIKIAKYAIDHLVIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHS3</accession>
    <name>A0A3D8SHS3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_04191</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHS3"/>
    <dbReference type="OrthoDB" id="10264639at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_uS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_uS7_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003106">
        <property type="entry name" value="PRK04027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="65"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW85866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="214" mass="23831" checksum="5CA4CC155A57DBCC" modified="2019-01-16" version="1">MSDSGEIEVEAVEGYQVLPKEVVSEIGSIKLFNKWSYEDVEIRDISLTDYIQIRAPVYISHSAGRYAQKRFRKAQCPIIERLTNSLMMNGRNNGKKLMAVRIVAHSFEIIHIMTDQNPIQIAVDAIVNCGPREDSTRIGSAGTVRRQAVDVSPLRRVNQAIALLTIGAREAAFRNVKSVAECLAEELINAAKGSSNSYAIKKKDELERVAKSNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHT7</accession>
    <name>A0A3D8SHT7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cellulase</fullName>
            <ecNumber evidence="3">3.2.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_04188</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.</text>
            <dbReference type="EC" id="3.2.1.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the glycosyl hydrolase 5 (cellulase A) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.4" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHT7"/>
    <dbReference type="OrthoDB" id="5823761at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001547">
        <property type="entry name" value="Glyco_hydro_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34142:SF1">
        <property type="entry name" value="GLYCOSIDE HYDROLASE FAMILY 5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00150">
        <property type="entry name" value="Cellulase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017719792" description="cellulase" evidence="7">
        <location>
            <begin position="19"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 5" evidence="8">
        <location>
            <begin position="145"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW85863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="448" mass="45921" checksum="5F94D29CE19F6298" modified="2019-01-16" version="1">MRFSTYLLAAGLSATAFAAPVAVDTSYDECEADPAPSSSAVAVATAAALSTSIVPTTAAAAVATPSASSSAAAVATPSVVSSAAAVASPSTSSSAAAVAVTSSSAAAVATSATSSAAAAATSSSSTSGITVSGGTNGTMYWLGVSESGAEFGQTVLPGTLGTDYTWPNTTAIQTLIDLGMNVFRIPILMERISPTSITGALDTTYLADLKTVVNYVTAAGSSAVIDMHNYGRYNGATMSSTSDFQTFWNNVATEFATNDLVIFDCNNEYHDMPTNTIVAELNQACIDGIRAAGATSQYIFVEGTSYTGAWTWTTSGNSEYMGNITDPENKVIYEMHQYLDSDGSGTSGTCVSSTIGAERLAAATTWLRENNKIGVLGEFAGGANTVCETAVTGMLDFIKANSDVWMGALWWAAGPWWGSTYFSSMEPATGEGFVAYKDILAKYAPTAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHW0</accession>
    <name>A0A3D8SHW0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_04252</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHW0"/>
    <dbReference type="OrthoDB" id="270167at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF20">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="6">
        <location>
            <begin position="59"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW85927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="396" mass="44543" checksum="70875584137F195D" modified="2019-01-16" version="1">MEKVMNVPRDNANADTAFLLSCMKLLLHTPQSGSLPEALPLYRIIKAVALQLELAGLQSLMVIQSELLIAVYELGHGIYPAAYTTVARCARQAISIGIHSREAPHFLQPWAEWEEEIRVWWFIVMLNRHVTVGRELRPLCTENPSKHTPLPADGDAWDKGAMIASERLYVSSPTTARASPYARLAQAYNLLGRVIRHCNDPIQDLAFMLDEMSTLHQATSALLELIASEESEGSYVGLAVCFGYVRDVVQAFNPAKSSANLTSTLMKLHKNFLYHSFRQGFLDQADFQLTARIREYTEVSFNTMRDTSLKALILAQSLEQQIVVSGVDKLSPLVLHCFYRAAFWLSYLVSANREDRFVVGLSVFDRVFKALNLRWKAAGTYLTLIEAVNKENRVGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SI68</accession>
    <name>A0A3D8SI68_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_04297</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SI68"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140115">
        <property type="term" value="P:export across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042908">
        <property type="term" value="P:xenobiotic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000460">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF33">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="348"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="392"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="493"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="120"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW85972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="561" mass="61647" checksum="FD554CDFC46B146C" modified="2019-01-16" version="1">MKIQDWQEKELEVGIASAHDSLEATEAGHQSDPQMTERSTNAGPPPSGTDADLCQSKSQGNFMTKLERAVSTLSSSRKTEKRLERAKHPEMNLAENVVGWEGQADPTMPLNFATRRKWLLLILTSSTTLMVALTSAMIAPGVTYISQEFGNSSNVLDTIIVTIFLLGFAVGPIVLSPLSEIYGRKLILTCGNVFFLLWQIGCALAPNIASLIVFRFLAGVGGSASLTIGGGLISDLFYIDERGTASSMYAIGPLFGPVLGPICGGFIAERLGWRWVFWVLLIFSAILLLTLEIFSKETNHRVIMRWKVEKLRKELCNDNLRSCYDDPGAALRTPSETLAISLIRPLKMLFFSPILFILATYMAFIYGLQYLLSTTIPLVFQTTYHWKPELTGLAYIGLGLGFFGGIMAVARINDATVVRLTKANHGVPEPEMRLPACVLFACFIPVSFFWYGWSTFYETHWVVPIIGLIPFGLGQIGVFIPIQTYVIDSFPEFAASGMAALTIMRSLLGAVLPLAGTKMYDSLGLGWGNSLLGFVAMSLIPFPILIFKFGGAVRKKYPLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SIQ2</accession>
    <name>A0A3D8SIQ2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">BSD protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_03993</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SIQ2"/>
    <dbReference type="OrthoDB" id="73788at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051494">
        <property type="entry name" value="BSD_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019:SF5">
        <property type="entry name" value="BSD DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16019">
        <property type="entry name" value="SYNAPSE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00751">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BSD" evidence="2">
        <location>
            <begin position="223"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="288"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="353"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW85668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="391" mass="43186" checksum="48996919A842874D" modified="2019-01-16" version="1">MDLAYDQIIQASVKEQEKKDDQDEKPEQTLNEDFQEAYKAISSSPWGAKLGGFFGSVVKQGESVYKEAQQELTAVSEEATKGFTDLRSSIISRTRGLSVAQKPAEGEASASTDEATKESEGVLATLRSEAAKRLKEIQKAEDAADEALLKFGTNLRNYLKDAITIAAPSGDDKDQNNTVLFESKDAQGKRVIHTTRFDAQLHVIHSSLDSFTKDPVSEEYAPWAKYFDVGNKTEDISKDLENFAELKTSMEKLVPDQVSYEAFWKRYYFLRHSIETAEARRRDLLKGAAAEEEEEVGWDEDSEDEAPVKGKADAGRPASTESSTTLHPATSQTPQIDLKPEQGRKSHDEKSQADSDGSYDVVGAASGAPSHAPNSPKESRKGDESEEEDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SIY3</accession>
    <name>A0A3D8SIY3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SIY3"/>
    <dbReference type="OrthoDB" id="5408025at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027915">
        <property type="entry name" value="DUF4452"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39615">
        <property type="entry name" value="YALI0E17897P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39615:SF1">
        <property type="entry name" value="YALI0E17897P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14618">
        <property type="entry name" value="DUF4452"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW85748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="184" mass="20173" checksum="78626DB9A1743D1C" modified="2019-01-16" version="1">MSSYYHYNSHQHPAAVSAQPAATHHTGRGRRAPRLSQNAHKQFRSVRKDEEAAALVTFRQRFEAGRSFDLDDDLEFCPNLLSEVDLVSIHSSSSDRSSLSSGSPEASPQSTQVSPSSGFSLNSNSNPYITSAYQSQPQSLKLHQPAATRIRNAIPIVNPSTGIRMSSPPQSVSPARMQALGRRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SLV2</accession>
    <name>A0A3D8SLV2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_02987</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SLV2"/>
    <dbReference type="OrthoDB" id="2384350at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17716">
        <property type="entry name" value="BRCT_microcephalin_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022047">
        <property type="entry name" value="Microcephalin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14625">
        <property type="entry name" value="MICROCEPHALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14625:SF3">
        <property type="entry name" value="MICROCEPHALIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="2">
        <location>
            <begin position="871"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="291"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="581"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="684"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="783"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="843"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="999"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="26"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="357"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="525"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="807"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="999"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1043"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW87293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1161" mass="125332" checksum="83F40DADCE84924E" modified="2019-01-16" version="1">MSEPSPPVRVTRARAAAKTDPKLNIATAASKAKTSRTTTATKRKTRADESKDDDQDELNETLPAIIEPEAPKTRGRQKKAPAMQSEPEDAPAPAPKPRGRPRKTVVEVEAPAAEPSRATRGRAKKMEDANNVDDEIVVAVEPPKRTTRGRTATVSKPAAPKKTVKFEEPDKENLIPTATKEKAKVDAATGLRAKPVRKPVAATTTRATRGRAKVEENPEKTSPLSPKKITQIATAKETSEDELATTEKTPMKPLMKSPVKPPGSIFGAAKKLDFTSNNITANRVSVHQDLSASMMASPARRPPQSPFKDALKSSPQKLVFDNSLTRSPFKPSFPAPKSAAKDPELKASLLQSPARRPQSSPIKVTDNGSPSKSHSSASLFGQTPKATPFKISRFGTPKTISMTPRQPLMASLNTAKPAATPIAQEVQGTSLEFSGRLSSIMPREADPAFQTEEVNAEEAAQASEDNEMPAPESMAIDEVDNEIDASLVPTFDETNSSEAAPSSAFRLRKRDESPFDDSDSEDELASSSPRYSPSAQSAATPSSFAVGNRTPGTTFSKKRAANLSEVGFTPLAKQLSTWMAASPEPVRGSGSDTEHPSPLRSNPVSVEVQEALVQPSPAKSTFFEDAMAACDESAVVDDAPVFLEEDPNFSPVELLVEDLDLAAEADEMSILEQDVAEDVEECVEEQGHENMKDDIEEGSPSCLDEPALEPEPVVETQAEPELIDESGPAPSEASQEYGDENAIPIDPELLPLPESQAPSFSTPKRVLAERVFHTVSKVPLKPAAEDSPVNVQRKKRSASISRLPVSRPSSKLSRSNTVISYSPAKNITQSARRQVTLQDATMADAPETPSKPETVDWSTVGTPARTPRRDLNSALLKGAIVFVDVHTSEGADASVLFTELLTQMGARCVKSWNWSGNGEESGKVGITHIVFKDGGKRTLEKARATGGVVSCVGVGWVLDCERENKWLDESIYAVDTAEIPRGGHRRRKSMEPRALANMNGTLMTPSAKTPMKNNSPTKEFLNLETPGTSKSRRRESLQWIRSPASSTSTEDQLDDQTTALSPIPATPAPETISAYGEAYLDRLNAGEQTPGEESPYFLHQEKIVQMTAPPKQRSAPGDGMGFLSTKKDESVMMRLMAARRKSLQWAPKVGSPLKESSHWAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SLV7</accession>
    <name>A0A3D8SLV7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD/NAD(P)-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_02946</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SLV7"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF3">
        <property type="entry name" value="FERROPTOSIS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="5">
        <location>
            <begin position="44"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW87252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="408" mass="43971" checksum="B0C4D46520EDFA59" modified="2019-01-16" version="1">MLNIFRLAANTIRQATKIVFQLLTGTYIAAPISDSTLPPRTMKHIVILGGSYAGISTAHRLLKKASKLGPLKVTLASPNSHFYWNIASPRGLIPGEFDDEQLFQPIAAGFRQYPAEQFEFINASAEDVDIQAKKVTLSGSRSISYDFLVLCTGCRTKEHTPFKGLESTEATKDALHELQMRVKAAKTIVLAGAGATGVEIAGELGYKYGTQKKVILISGGSTVLEGRPSSVSKATIKELQKMNVVVKLQTKIKGSTTTSDGQQELALVGGDKLVTDLYIPTFGVTPNSSYLPAKFVNADGFITVDEYLKLKGAENVWAIGDVSEVEPPQFMFCDAQSVHAAKSILSILANKAILPYKASTSSMIGIQIGKKVGVGHFGGMKIPGFIVATMRKSLFTQRLVTMLDGSEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SLZ7</accession>
    <name>A0A3D8SLZ7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Reverse transcriptase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_03024</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SLZ7"/>
    <dbReference type="OrthoDB" id="74545at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37015">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37015:SF2">
        <property type="entry name" value="REVERSE TRANSCRIPTASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW87330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="854" mass="97963" checksum="429599025A95DED1" modified="2019-01-16" version="1">MASGDVLSNTLSTITSIKLAEITQQRIRFEESKKALLLAVQNEPDQSEKIRLLLNCVDELPSMTKFDSNPAISFPHIRRFVNQADLDPSVPIHLQKAWQEKLEAELEVHSQKYNYAALYGQLVNEWLAASAKVTSATESLSESTFEEVGRKEMYEQREIYEKYVFEAKETDQKAIYAYLEGLFSSNHATTTAFASLKRRVVEFEKSLAAKKHFDEASLTSVAKSLLQSDLLDAQKRGTLKDFLNNKVVLGELADVLNMRMSSLDKWSWDPAGIPIEQRRQLNGKYRVYQDEDLLQTLLLRYIGIQWNVFFRTLLIDFREAPDTWPVTAKPMTKLDRKRRLYFLGHEGYKASVDDTREAYYSDSIFLEQLQDKVDENRGYDDDSCDGGDARKKPLEIMQSLLHTVATEVILKTRLGEEITVVRSDFKWFGPSLPHSTIFAVLNFFGVSEKWINLFRRILECPLRFIHDGPDSPVRRRKRGVPPTGPLYDVLGEAVLFCLDFAMAQQGTRLYRLHDDIWFWGSDETCIQGWAIMSKFAEVTGLEFNKDKTGSVKITRKGNAAPAVAVGLPTGDVRWGFLKLDAVTGKFLIDREVVDTHIVELRRQLGACKSVFDWIQAWNIYGVRFFTNNFGTPARCFGLDHVDMMLKTFQHIQAKLFPNGSATTHLRESIIERFKVQDVYEGYLQFPISLGGLDLKNPFMTLYYEGNSMDKNVDKSMDDFFETEQRKYQILKKQFEDGMVSVPSGALGPKDEFGDEFMSFEEYTRYRELTSSLLTRAYKTMLHVPSRARPAATPEVANLQGQISWDTMDAYDCWTVQLYAPEMIKRFGGLNIVEKGLLPTGMVNMLRENRFKWQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMH5</accession>
    <name>A0A3D8SMH5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_03211</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SMH5"/>
    <dbReference type="OrthoDB" id="10510041at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017721387" description="Extracellular membrane protein CFEM domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW87517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="174" mass="17048" checksum="E0B32403D0FB441B" modified="2019-01-16" version="1">MRFSILTLAMIASAAMGSDAFSLARRETPAQCQTELDTCKTTGTTEAQCELNYTACIGTRTSALASSTASSSASDLAQSVSTSTTATTTDSASLTTSTDTSAGVETTLTGVVTDAVTSTSASDSASTATATSSRSQTGSSTSSSASSTATSSSGASNVNAPALGLLALGAYVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SN26</accession>
    <name>A0A3D8SN26_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_03411</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SN26"/>
    <dbReference type="OrthoDB" id="2019572at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051589">
        <property type="entry name" value="Sialate-O-sulfotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964:SF5">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="131"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW87717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="229" mass="24220" checksum="7B6888C9CEFC81EF" modified="2019-01-16" version="1">MTPRRTETPLFKNSSSPAAATRTYPGAGEVGFPTLSPALNVTGGLNTTRPVPTLFSPTLVPSSPSFPNTSTAVAITTPSLLAHPTSSSTNSSTVALFHTVNKPPSTSSITTHVKTSSSAVSKPSIAAKVGKYIFKGCYIDGKNGAKPLARILPLQHFFKGTLTPEKCAKTCEGYKLFGLAWSDECHCGNNVAGTKDLDPVQAHCNYLCDGDPDQICGGSWRLNLYELEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SN71</accession>
    <name>A0A3D8SN71_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase II elongation factor ELL N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_03315</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SN71"/>
    <dbReference type="OrthoDB" id="2587563at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2670">
        <property type="entry name" value="E3 ubiquitin-protein ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042065">
        <property type="entry name" value="E3_ELL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019464">
        <property type="entry name" value="ELL_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10390">
        <property type="entry name" value="ELL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase II elongation factor ELL N-terminal" evidence="2">
        <location>
            <begin position="152"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="411"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="431"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="504"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="582"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="601"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW87621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="713" mass="78295" checksum="1E90A282F742DC39" modified="2019-01-16" version="1">MPSLTVPDAGLTLDASRPPSKHGAAGPMAFGLTLADSVIENMIKCFQENKPIHLALGESPKIQYGSKTQHLAPSDDPFTHELYQSTSSRQSSPEAEPRYLAMFSHTQFLPRARPITAQSAAAKSKAAAPASSQDPALAALQGALASENAKKAENTTKYIKDGTLPLPGKRGAAKVTNKSKFLSQNRSLGSDTTRSMPTSPALSGVGSPSLGPTSVPLSQQKAERAKEARRPVIHYLALRPFSEREILSKIGGDQTETYDALQKVADEINGKWELRKNYWKELDVWRFDYGSEDDRQMVIDNAVKQYDKMRMGISEPQWDRLLPKEERGTGKCLSKLQAKIASGSAKAPKISVSQADGSGQDTPGRMDEAEVEDKSLSRVKDGESRSASQPPATKTKKTSEREAQAKRLLSKTGPKPAKPAAKPAVPKKTKAPVEKEREKGKVLSSQYVEDSDDDGEDTVIVSKAPPKPIKRPREAEVDKSHMNQAPASRKPKKDTPTPNHRISDASQSSRSTHQSSTSFKSKGTSPQKSSPLASSPPTNASDFENDHASHGRASSSASPYNEPQPKVKRKREDEEPIRRQQSSSNSSISSSHPPIKRQKSDSISSSSTATSTSSRQSYGLPPNIANKEEYVDLARRFKVYYPRYQQLHKELQESKVHDPEKEEILLDMHDRLSNLKAEIMLKLVNNNLPTKRTQGADWRPITNGGSIDYRPYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SNR0</accession>
    <name>A0A3D8SNR0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03122</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SNR0"/>
    <dbReference type="OrthoDB" id="5223508at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd23703">
        <property type="entry name" value="mS26_PET12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058940">
        <property type="entry name" value="mS26_fungi"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26163">
        <property type="entry name" value="mS26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW87428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="302" mass="34238" checksum="E3D3BBFC4607C13B" modified="2019-01-16" version="1">MSSSLSRPALSSLCRSCLTSISSRTFGTTAPLSRIGPESPRFIDIPQPPQQSAKAPRDIKGTLPTPRKIFLSRGVDKTDPEYFARTAPEPTSAYKLSEPQNDRIAWKRQMAETRRSHLREGLLELHRRKVAQEKSMAKESKKKRDIREQKFYAPQREDERLTSPTIRSLNSTLQKGHLPDPEREQRLVEKAAHVQEHQAAKEAARKNALHTLYMHARNFITTEEQLNAKVDELFVDYPWQDTNAGRSTNIWDALGAPPTVQDMLTSINKTEKQAIKFHSGQAIVTGERMKKLAEELTGGKMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SNW5</accession>
    <name>A0A3D8SNW5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03565</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SNW5"/>
    <dbReference type="OrthoDB" id="4898680at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW87871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="212" mass="24183" checksum="551232C88C0BD786" modified="2019-01-16" version="1">MTRARRTATQSPLSTPNRPVEASLRETIRDLIARCRLAYDSLPPTTHYYKYGTTPKDSTGRALLDQAYLMLLNLQNQFLVDRVANARGFPNDQRLFDTAMEMLQLSNMYWIRRDELAGFIIILTGSSAVICVELLDQAKGQSALHFSRSDAIQKLTVFVHFLEWIRPTDGNYALTQKLKTVVKSVIDHILDSPQRQQLGQRETENGRDGLLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXV4</accession>
    <name>A0A3D8SXV4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02308</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SXV4"/>
    <dbReference type="OrthoDB" id="4684492at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="366" mass="42332" checksum="88FD1387B8F1AB17" modified="2019-01-16" version="1">MTLVTIKTFSRLQEVLRLTCSPAAFTTLCVYLLALHQMGWELPAEAFDLFISEYHKFEEQASSEPRWFSYHSWFQERMAHHSVPRPPVTTLTLHTLETIRAENPYTEAYVQRCLGHIIKEHLRRDRGVADAAPAGKVRPEPRAVPTQGSTQSRTTPTPSPGEPAWTIPAPHGSSEARVDMLDQPWHSEKGLREVLGLRNREELLVWLKQDWVLDVYDEYCIVELDPRRQRELALLRHGHAVPSSFKTSWADYLIGAAAAALHHSLPRYCRANPPKHHWTRDDHDVRFIAQLVLAGRESGRWWEHRRGEDTRQLCTYAYRLLCWLRNVHRISSARGQSTQIQRAAANHWVEHLTHARSLRQTARSHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SY84</accession>
    <name>A0A3D8SY84_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Malate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02399</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SY84"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021851">
        <property type="entry name" value="DUF3455"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567:SF3">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35567">
        <property type="entry name" value="MALATE DEHYDROGENASE (AFU_ORTHOLOGUE AFUA_2G13800)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11937">
        <property type="entry name" value="DUF3455"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017543321" description="Malate dehydrogenase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="235" mass="23629" checksum="8630D59C181EAB75" modified="2019-01-16" version="1">MPSLRNLLLGAGLATLLQAVGVAAAPSRSLPSPDIQRDSNCIPRFPAAPPTLPTTGDATELPSPAANMTLKFAAVGRGIQNYTCAASNSTPVALGAVATLFDGTALAGTNEAALNALPAAAVYSPVPTTSLTLHGNTLAMLGHHYFDATGAPTFDLSAFGDLLVGKKIASVNAPATADSGPAKTGAVAWLQLQDAGGSKGVSEVYRVVTAGGNPTACTAAGVITVQYAAEYWFYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYB2</accession>
    <name>A0A3D8SYB2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Plus3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_02451</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYB2"/>
    <dbReference type="OrthoDB" id="166375at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990269">
        <property type="term" value="F:RNA polymerase II C-terminal domain phosphoserine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.200:FF:000005">
        <property type="entry name" value="Related to Pol II transcription elongation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.200">
        <property type="entry name" value="Plus-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004343">
        <property type="entry name" value="Plus-3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036128">
        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13115:SF8">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03126">
        <property type="entry name" value="Plus-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00719">
        <property type="entry name" value="Plus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159042">
        <property type="entry name" value="Plus3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51360">
        <property type="entry name" value="PLUS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Plus3" evidence="6">
        <location>
            <begin position="252"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="122"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="528"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="71"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="185"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="233"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="528"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="543"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW91286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="600" mass="66389" checksum="2848F5FF576AE8A2" modified="2019-01-16" version="1">MADIDDELLALAGDASSDEEETNDISRASSVTPDKSASAQKSGGRKKGRRNDSEDEGEISSANSDRSVPMDESDSDSDAEPELEDEGDKYPFEGKFLDAAEKATIMALPEIKREEILAERAQEVETDRQNRVLRQFINSRKADERKRDKKRKAGNAGLDEDDRKPARQRTKLGGGKVGESSSGIEKFKRAKAEKDDRNRRREEDRARNKGGRDTGLDDFSDHDVGAESDVEWDDGKSKAKKADSPDLRDSEPAGLQELQRVRVGRSQFAMVCFYPGFEEAITGTFVRINVGNDKGPCYRMAVVKGFTEDRPYAVLNANGKSITTTQYVRAAHGKSEKNWPFFSCSESPFTEAEWNRYKQTCLVEGVPLPKKGKVSQKIADINNLVNRSWTEEELQAKLTKSGALVNKYIPIERNRLNNAIKEAKSAGNEAKAAQLRAELEELEGPKLAYGTSMQPSPKKTASPAGLSQQERLAVLNKQNRQKNIQEVRQALINERKAAKMTEAALARGEVVTEDHSKRLKTRAKFKHDVSEGFGPKKTDSDRSGTNTPAAGTPNLTANKPSTPLPHLQRLQSNGGIPKLRRPVMDDDIIGSLDLGIDLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYH6</accession>
    <name>A0A3D8SYH6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Translation factor GUF1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_02538</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.n1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Peripheral membrane protein</topology>
            <orientation evidence="9">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the GTP-binding elongation factor family. LepA subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYH6"/>
    <dbReference type="OrthoDB" id="1074at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097177">
        <property type="term" value="F:mitochondrial ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045727">
        <property type="term" value="P:positive regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03699">
        <property type="entry name" value="EF4_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01890">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03709">
        <property type="entry name" value="lepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000078">
        <property type="entry name" value="Elongation factor 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000015">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000007">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2570:FF:000001">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000004">
        <property type="entry name" value="Translation factor GUF1, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2570">
        <property type="entry name" value="Elongation factor 4, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00071">
        <property type="entry name" value="LepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006297">
        <property type="entry name" value="EF-4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038363">
        <property type="entry name" value="LepA_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013842">
        <property type="entry name" value="LepA_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035654">
        <property type="entry name" value="LepA_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01393">
        <property type="entry name" value="lepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512:SF7">
        <property type="entry name" value="TRANSLATION FACTOR GUF1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43512">
        <property type="entry name" value="TRANSLATION FACTOR GUF1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06421">
        <property type="entry name" value="LepA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="63"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="72"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="136"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="190"/>
            <end position="193"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW91373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="661" mass="73966" checksum="4D3633DEB1AA1243" modified="2019-01-16" version="1">MQRWALRFSRLHSSYRCSHERQLHRHHDILAAARAFSTSIARCAQPSKITSDLERRIAAIPIDRFRNFCIVAHVDHGKSTLSDRLLELTGTIQPGGNKQILDKLDVERERGITVKAQTCSMLYNYDGEDYLLHLVDTPGHVDFRAEVSRSYASCGGALLLVDASQGVQAQTVANFYLAFSQGLTLVPVVNKIDLPSADAPRALEQMKETFELEPENAVLVSAKTGLNVEACLPNVIRQIPCPVGDHTKPLRLLLVDSWYDNYKGVILLVRIFDGTVKAGDHVVSFATGKKYFVGEVGIMYPDQTPQNVLRAGQVGYIYFNPGMKKSTEALSGDTYTTVGSEKLVEPYPGFEEPKSMVFVAAFPVDQSDHGHLEDSINQIVLNDRSVTLQKQSSEALGAGWRLGFLGTLHCSVFEDRLRQEHGASIIITPPTVPFKVVWKDGKEDIIENPAEFPDTDAYNGRVAELQEPYVSATIALPEEYLGKVIELCEANRGEQKELKFFTATQVILKYDIPLSQLVDDFFGRLKGATKGYASLDYEDAGWRRSNIVKLQLLVNKAPVDAVARVVHTSQVQRLGRQWVTKFKEHVDRQMFEIVIQAVAGKRIVARETIKPFRKDVLQKLHAADIGRKRKLLDKQKEGRKKLKAVGNIAIDHKAFQKFLAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZ79</accession>
    <name>A0A3D8SZ79_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ABM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_02798</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZ79"/>
    <dbReference type="OrthoDB" id="3542212at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42052">
        <property type="entry name" value="ABM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42052:SF1">
        <property type="entry name" value="ABM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW91633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="23962" checksum="7E209B0FAF127116" modified="2019-01-16" version="1">MPILEVLQVRLKPGTSPQDPTLLANLRMVRSRIGTNSRFYICIEDPTLLFILGQWPTLDAHRNFLKSPERDEILSAQDDQLEFRYMIHLEFGGMETLPLHAPVMALARLFINPEGKHPNQFLVKVQKHRHVIVDGSQAAVVDGWRVDGTEAEREYWMFTGWDSREAHDIFREKTRSEIPEYKSIRDHYLGMDVLHAKDLEVLSGESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZQ5</accession>
    <name>A0A3D8SZQ5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_01154</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZQ5"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051531">
        <property type="entry name" value="N-acetyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792">
        <property type="entry name" value="GNAT FAMILY, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00765)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43792:SF16">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13302">
        <property type="entry name" value="Acetyltransf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="30"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="188" mass="20572" checksum="0591AE6C2B5EBEB9" modified="2019-01-16" version="1">MVYKDGSNPDHTDCELAILNSATAHAKMGDYGIRTPQQLNDLHETLKVRNVKYHGLPTEIDPNMMVRLGDKDGPLIGTVSLAERSKELPPDMGWGFIEGQMGMGYATEASRELLRFLTTDCGIKEILVWPDPENIASNRVAQKLGFVPGGDVIDLDKEGKLVPVLILPDMKKQDGTKSVSFYGDGGSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZU2</accession>
    <name>A0A3D8SZU2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_01194</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZU2"/>
    <dbReference type="OrthoDB" id="5153884at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW91800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="155" mass="17345" checksum="19D30887725C50D8" modified="2019-01-16" version="1">MNQQILDTNTDTRDQVAAFSNEANEVVSTLTQPLHYGHQNMLKPQESVSLPAPIMQNYDNPILKTPVTRTYLSKDTVNPRNLDPIHLKTVEMVRSKQRIALGPAGGWYAMGAISQHNLPSSLSPGVKSSITIISFRMKLEDPSVNKIFQEFRVNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0L9</accession>
    <name>A0A3D8T0L9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Septin-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_01478</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0L9"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000196">
        <property type="entry name" value="Cell division control 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="178"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="20"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="499"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="20"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="499"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW92084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="554" mass="63100" checksum="7F5F256732BF2139" modified="2019-01-16" version="1">MASTLAGLLVQSRGTRHELSKLLDASSKEPREQVPLEPHSYRRSLHQHQRPLAAAAAYRSMLDVEDPPIISPLALPNESMEDWVAEKLNQTARKHQTARSDWADILCFYTATEEAAAASPNGAPASPTLEIPQSVSSSDPKVAAQQASDMRNIVRRKLTGYVGFANLPNQWHRKSVRKGFNFNVMVVGESGLGKSTLVNTLFNTSLYPPRERKGPSLDIIPKTVSIQSISADIEENGVRLRLTVVDTPGFGDFVNNDESWRPIVDNIEQRFDAYLDAENKVNRMNIVDNRVHACVYFIQPTGHALKPLDIEVMRRLHTKVNLIPVIAKADTMTDEEIMAFKARILADIKHHDIQIFEGPRYELDDDETIAENNEIMSKVPFAVVGANSEITSADGRKVRGRRYPWGIIEVDNEEHCDFVKLRQMLIRTHMEELKEHTNNALYENYRSEKLTAMGVAQDPSVFKEVNPAVKQEEERTLHEQKLAKMEAEMKMVFQQKVAEKESKLKQSEEELYARHREMKEQLERQRMELEEKKSRIESGRPIEEKGKRKGFSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1Q6</accession>
    <name>A0A3D8T1Q6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Catabolic 3-dehydroquinase</fullName>
            <shortName evidence="3">cDHQase</shortName>
            <ecNumber evidence="3">4.2.1.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">3-dehydroquinate dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="3" type="primary">qutE</name>
        <name evidence="7" type="ORF">BP5796_01896</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Is involved in the catabolism of quinate. Allows the utilization of quinate as carbon source via the beta-ketoadipate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>3-dehydroquinate = 3-dehydroshikimate + H2O</text>
            <dbReference type="Rhea" id="RHEA:21096"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16630"/>
            <dbReference type="ChEBI" id="CHEBI:32364"/>
            <dbReference type="EC" id="4.2.1.10"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Aromatic compound metabolism; 3,4-dihydroxybenzoate biosynthesis; 3,4-dihydroxybenzoate from 3-dehydroquinate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homododecamer. Adopts a ring-like structure, composed of an arrangement of two hexameric rings stacked on top of one another.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the type-II 3-dehydroquinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.10" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1Q6"/>
    <dbReference type="OrthoDB" id="8191625at2759"/>
    <dbReference type="UniPathway" id="UPA00088">
        <property type="reaction ID" value="UER00178"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003855">
        <property type="term" value="F:3-dehydroquinate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046279">
        <property type="term" value="P:3,4-dihydroxybenzoate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019631">
        <property type="term" value="P:quinate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00466">
        <property type="entry name" value="DHQase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.9100">
        <property type="entry name" value="Dehydroquinase, class II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00169">
        <property type="entry name" value="AroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001874">
        <property type="entry name" value="DHquinase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018509">
        <property type="entry name" value="DHquinase_II_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036441">
        <property type="entry name" value="DHquinase_II_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01088">
        <property type="entry name" value="aroQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003804">
        <property type="entry name" value="PRK05395.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003805">
        <property type="entry name" value="PRK05395.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003806">
        <property type="entry name" value="PRK05395.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003807">
        <property type="entry name" value="PRK05395.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272">
        <property type="entry name" value="CATABOLIC 3-DEHYDROQUINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21272:SF3">
        <property type="entry name" value="CATABOLIC 3-DEHYDROQUINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01220">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001399">
        <property type="entry name" value="DHquinase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52304">
        <property type="entry name" value="Type II 3-dehydroquinate dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01029">
        <property type="entry name" value="DEHYDROQUINASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="1 3" id="KW-0672">Quinate metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton acceptor" evidence="3 4">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3 4">
        <location>
            <position position="103"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <begin position="104"/>
            <end position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3 5">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="3 6">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR001399-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW92502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="152" mass="16606" checksum="73A4569DDFCAED6D" modified="2019-01-16" version="1">MPAKKILLLNGPNLNLLGTREPGIYGTTTLADIESAAVSQAKAGDAELQYFQTNHEGQLVDRIHQARLDGVEAIVINPAAFTHYSVALRDAITGVNIPFVEIHISNVHAREEFRHKSFLSDKAEAVICGLGTFGYKAAIEFCMTEIKTRAKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1T4</accession>
    <name>A0A3D8T1T4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_01775</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1T4"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF20">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="220"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="320"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="352"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="429"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="1"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW92381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="539" mass="57953" checksum="01764D500DF3C809" modified="2019-01-16" version="1">MGLGVLEDYKLEHVPGTAPLNELGREVYNTSGVDSSILKHDATGTIVLVPQPSDSPNDPLNWSRAKKEKFTIAFAFAVGPLLGAAFVSLATEFNVPLSTFIQGVQGGVIIAIAFSSLIFNALAVKYGKRPIYLITSVGLVVTCFWAAAAKSFGSLVAARVIQGLCMGPLEALVPASIGDVWFVHERGFRNAVFNLGVLGGINLAQPIGGVIIQYSGYKTAFNAMGGAFVVQLILILLWMPESAYHRTNTIMTEIALSHKTDAQHIEEKTTATPTTTHEAVSTEPPQSWAKELLPYSGYINHVSFWNTLCRPLSLLASPAVLWATLLFTTCISWLVGISVTLSQIFSAPPYNFSITAVGCSNLSSFVASILATAVASPLIDGMVRRLSKLNGGTFEPEFRLPILISYLLFTVSGFFAWGQSAYAQDPWPVPVIVGLGFINFGIQLGTTGIVSYVVDCHRDKAGEAFAAMNFVKNLFAFGLSQYINSWIATQGVRDAFFVIGGITAAVSLTTIPMYVYGKRARSWTFRHNLAGKGAVHGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7X6</accession>
    <name>A0A3D8T7X6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_00430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7X6"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW94667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="90" mass="8937" checksum="9188AEBD9180D6F8" modified="2019-01-16" version="1">MATKSQTIAIAAGCGVGAIILLCIAYVYHLRAMQVRRIRARRKRHAEKGGSGYDAAEKGEAPPAPAPAAAPAPAPAPAPAPAPAAAAEGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T812</accession>
    <name>A0A3D8T812_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="11">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BP5796_00334</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="11">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the AdoMet synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="11"/>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T812"/>
    <dbReference type="OrthoDB" id="5852090at2759"/>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006555">
        <property type="term" value="P:methionine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000001">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000003">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000004">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00086">
        <property type="entry name" value="S_AdoMet_synth1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 11" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="13">
        <location>
            <begin position="17"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="14">
        <location>
            <begin position="129"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="15">
        <location>
            <begin position="251"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDW94571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="394" mass="43165" checksum="21F08E97DADF3FBF" modified="2019-01-16" version="1">MTAQTNGTSTHHNQGTFLFTSESVGEGHPDKIADQVSDAVLDACLAEDPLSKVACETATKTGMVMVFGEITTKTKIDYQKVIRGAIKDIGYDDSAKGFDYKTCNVLVAIEEQSPDIAQGLHYEQALEQLGAGDQGIMFGYATDETPELFPLTLQLAHKLNAAMSAARRDGSIPWLRPDTKTQVTIEYKHDNGAVVPLRVHTVVVSAQHSEAITTEQLRKEIKEKIIKEVIPAKYLTEETIYHIQPSGLFIIGGPQGDAGLTGRKIIVDTYGGWGAHGGGAFSGKDFSKVDRSAAYVGRWIAKSLVHAKLCRRALVQLSYAIGVAEPLSIFVDSYGTSEKTSDELVEIINKNFDLRPGVIVKELDLAKPIYFQTAKNGHFTNQNFSWEKPKELKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8C7</accession>
    <name>A0A3D8T8C7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidohydrolase-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_00444</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8C7"/>
    <dbReference type="OrthoDB" id="191270at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019748">
        <property type="term" value="P:secondary metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.140:FF:000055">
        <property type="entry name" value="Uracil-5-carboxylate decarboxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032465">
        <property type="entry name" value="ACMSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240">
        <property type="entry name" value="2-AMINO-3-CARBOXYLMUCONATE-6-SEMIALDEHYDE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21240:SF28">
        <property type="entry name" value="ISO-OROTATE DECARBOXYLASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="2 3" id="KW-0456">Lyase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="4">
        <location>
            <begin position="10"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU366045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW94681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="365" mass="39842" checksum="3F2228C882D9E637" modified="2019-01-16" version="1">MKTSGSPIVDIHTHVYPPSYISLLKARTSIPYVRSFPPSPSLRLVILPAEDTESTSRGRPVGAEYYDINEKIKFMDTHDIDISVISLANPWLDWVPSSEASQAAKDINDEVDAECAKFPGRLFAFATLPLSGGTDVIIAEIERLKTLKYMRGIILGTTGLGKGLDDPELIPIFKALQAANLPIFLHPHYGLPSSVWGERSNDYGHVLPLALGFPLETTIAVTRMILADVFSTVPDLQMILAHSGGTLPFLAGRIESCIEHDAHLQAEGKLGAHRKTVWEILKKNIYLDAVIYGDVGLKAAMQASGEDRIMFGTDHPFFPPLEGEGQRWKSVDTNYEAIKNARGEGSEGARLALGGNAVRVLNLST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9P1</accession>
    <name>A0A3D8T9P1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_01033</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9P1"/>
    <dbReference type="OrthoDB" id="10266980at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF0">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="200"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="8">
        <location>
            <begin position="69"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="314"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW95270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="361" mass="41363" checksum="516C72632EFDB086" modified="2019-01-16" version="1">MHDPFPIPQQPWLSKAVQPFADYFSLTTLPIHIHEVLFAFFSYTFINIVVAPRISTWLFPDKYPKLSRDRKINWDVHVVSLVQSTMINILALWVMFTDEDRKSMDWTQRIWGYTGAAGMIQGLAAGYFLWDLMISLQNIKVFGLGMLAHAVSALIVFSFGFRPFLNFYGCTFILYELSTPFLNFHWFFDKLDMTGSRAQLYNGLVLLAMFFSCRLVWGTYQSVRVYQDVWAALHHKPAGPSIHLDMLNNSTNAAMDAAAGKNAMPIHNDIMQFAGEEYIPLWLALTYLGSNVILNTLNFFWFAKMIETVRKRFQPPKERKTKEKAVAMRSTGANGSKKITVDETEVRRRKVGEEEVAPPAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q3P9</accession>
    <name>A0A3D8Q3P9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_13146</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the asaB hydroxylase/desaturase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000026">
        <property type="protein sequence ID" value="RDW56505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q3P9"/>
    <dbReference type="OrthoDB" id="412788at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044053">
        <property type="entry name" value="AsaB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041278">
        <property type="entry name" value="CmcJ_NvfI_EfuI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598">
        <property type="entry name" value="BLL6449 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34598:SF3">
        <property type="entry name" value="OXIDOREDUCTASE AN1597"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW56505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="283" mass="32469" checksum="CCA51AE909115B16" modified="2019-01-16" version="1">MLNAHDNRPSDVFADINYFAADGQVREVASWRKRYLGIGDEHTRKMRVHDIRPFADHFTLDKNGFQFTNLAPKNRDTNDEALIKREYYKEVEELVKNMTGADVVYVFNHAIRRASTNIIQGVPDEKGQVPSGHPHVDYCGVPELMEGTKKELSLPEEIKRLFASSLRFSFINAWRPIQTVERDPLALADATTVPDSDYLVRARTFPSGINAGNYIMSHGSQEQEHQWYYMSEMQPNELVVFKGYDTKQDLPGWRCPHTAITLPDTESLPSRQSIECRAACFWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q474</accession>
    <name>A0A3D8Q474_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Extracellular membrane protein CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_13131</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000026">
        <property type="protein sequence ID" value="RDW56490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q474"/>
    <dbReference type="OrthoDB" id="3552651at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017706495" description="Extracellular membrane protein CFEM domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW56490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="121" mass="12718" checksum="3E61273CAB2D55E5" modified="2019-01-16" version="1">MQFQFVFAAWFVLFASVAAAPAPQDPAVQCWSTCSTDCVNSGSLRGGLYSTDGTCTCLSRVKERAAEPAPQDAAVQCWSSCSTDCVNSGSLRGDLCSTDGVYTCLSGVKERAAEPVLQSSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q4S4</accession>
    <name>A0A3D8Q4S4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_12880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000024">
        <property type="protein sequence ID" value="RDW56813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q4S4"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051589">
        <property type="entry name" value="Sialate-O-sulfotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964:SF9">
        <property type="entry name" value="SULFOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45964">
        <property type="entry name" value="WSCD FAMILY MEMBER CG9164"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00321">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017663377" description="WSC domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="40"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="3">
        <location>
            <begin position="146"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW56813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="246" mass="25770" checksum="6ED72AE28879520E" modified="2019-01-16" version="1">MKASFVSSIAVISAAIGNVYAQNSTSTSCAAISTPSPAGPYVYYGCMTESSLSRTLNLATTENATMTPEVCASFCSSQGYPVMGVEYGEECYCGTYPTGDSTTAPQSDCNMECTGDAGQLCGGSDRLNVYTLQNYTRPTIPRMADGYIYAGCYTDDPSNRALGLASLVDYTSMTVEKCAAFCSGQGYSMFGLEYAGECWCGNSISTGNTIAPNQDAECTSTCPGDETELACGAANRLNVYLVLLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q533</accession>
    <name>A0A3D8Q533_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">FAD protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_12864</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000024">
        <property type="protein sequence ID" value="RDW56797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q533"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="8"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW56797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="432" mass="47693" checksum="D908488C36ED07DD" modified="2019-01-16" version="1">MGFGSKRIAVIGGGLGGMAFANAALYAGLENIQLYEQAPAFTEVGAGVNITKNANVVLDSYGLKEAMREKSSHEPPFYMQYRNYKTGEVFGQIDEFGFPATRQIHRAHLLDAMRGRVPGSILNTGKRLAAIERSKSSDEYILKFQDGTTATADIIIGCDGIKSAVRAHLGFADQPNYSGQMVYRGYVEYSDLSPEADLELRKTVIYRGKQRHVLTLPIGNDLSKTSRVGVIGFMTEPLEDWVSESWMAKAPVDKLAEQVEGWAPTVQEIIAGLRKNAARDGNDLILKQALYVRDPIPKWYKVEDSHPGSGIILVGDSAHSTLPHQGQGACMAIESGVALATILKNWKSDDLESAFSFYQNIRKPRTDKITKTSYEAGKLASADTPELTSETFNPDALRERMKWIMDYDVLKDVYEQGVPYFETSTAQVQAQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q5V5</accession>
    <name>A0A3D8Q5V5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_12656</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q5V5"/>
    <dbReference type="OrthoDB" id="5296at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44229:SF4">
        <property type="entry name" value="15-HYDROXYPROSTAGLANDIN DEHYDROGENASE [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW57206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="290" mass="31291" checksum="176D3F6146685657" modified="2019-01-16" version="1">MALQVDGKTALVTGAGSGICLVFTKLLLSHGCNVVIADLGLRPEAELVVHREASQGAKAVFIKTDVTNWTELRAAFDFAIERFGSLDIVCPGAALFEPAWSNFWRIRDSADNETTSSFKTIDINITHPIRATQLAVDSFVRQKLGHGVVIIISSIAAQLAFLPTPMYAASKHAMSGFTRSLADLEPKLNIRVNAVAPGCVRTPLWTQDKMILFNEEADSWVTAEKVAQVMLDLIQNKENVGGTVLEVGIDKVRAVAQLNDSGPQGKGHTLTGLADGTVEVYETIAEQFGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q5W2</accession>
    <name>A0A3D8Q5W2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_12649</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STIG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q5W2"/>
    <dbReference type="OrthoDB" id="5596743at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006969">
        <property type="entry name" value="Stig-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04885">
        <property type="entry name" value="Stig1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017814583" evidence="3">
        <location>
            <begin position="19"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW57199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="163" mass="16656" checksum="A0DF54143185BC9F" modified="2019-01-16" version="1">MYFTTALALLGLFQAATAAAPACAADNCLRAARGKAIATRSPASHCSSYFKVTVTPVTTIHVISPTNIEVLVNQVTITASNIPAYAAAPCSGPVRYSSACSCAGATLVTTTIIPTPTCNLGQIVCSGDICQDVLSNDDNCGSCGKVCPPDKRCGNGQCTDAYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q637</accession>
    <name>A0A3D8Q637_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12733</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q637"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="88"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW57283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="420" mass="46336" checksum="5B6163CFC2D3593B" modified="2019-01-16" version="1">MHVVLPFVDETKDIEKEYDDHSETLLEHELSRGDVSSFTLQGTQTIGLQETSEHPAIGTVPLSVQIGATVEDADSQAVTERIGGDAQLSRSSRPSEYLSSQVPRIPDVPIYSTGNNVTVIHVGSHGPNQNDNLNPSSGEVLRWPINDHIKAGLLTSYFQDASKWCEVTDSLNPFSTGWSHLVVESQAFAAAAVALASMTRLRRDSTSTLLVRELYLFARETLQRLKSEHHEGALFATILLCMACSASEKMEEEQEMLHDCVKLLQSTTLNNVPDGILSACFWAVARQGRELRNLLSSLADEFIDIWAAYLGGRSTLISPETWITVQGKALHAPIQDRYSNQAISITARIIDELSKRPVGMSEDMIRNLWAELQIWIIERPPSVRCIMEVEASGDSAFPTILFSNPSAGMKASATRNPLAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q695</accession>
    <name>A0A3D8Q695_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12779</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q695"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="43"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW57329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="757" mass="85802" checksum="56C9EBA9E2E85A8E" modified="2019-01-16" version="1">MESDLYFDLHSREIRLVKLLKGQWSDELRCVLYHAPLANRPTYKALSYSWGLAGKPRVVLLNGCKHSVTASLESALRRLRQSDDDVSIWADALCINQSNNSERTRQVGLMHEIFSSAEEVIIYLGEVSDPGSLRSARQKRDTDSTIMTTFGYNDTDRDKLDIFRSHCSADQSPTTIFKSIKKIDYAFDVFCLLRCLAEGQHLERILPNDSGSQQIMVSEYQRKLFEALRSIMNARWWDRIWVIQEVIVPQNLTIVYGPMVAPWEMFVDAARLCFRGGTSTTLSSFPRENMIVLEFFRGQVLDIDRMRHLWRSGKQPALLSLLRRFSGRKATDDRDKVYALLNLASDGLSFIPDYTQDVSAVFQTTVLEIIRQSTKLNVLSGDLGRKDRQDLPSWVPDWSAAYDDLDRRRADDTENYDATHGSELYVVDENAGRWSGVREYLKPGPVVPKKDEVPSEAVERTYNDTLGTSEWTKYLVTSVDDETLSEDDCLSAIECFYTSRGNPGYLRNYDRGIVSLSGICIDKISITGEVSFSDKDLLTIVPSWAFLVKTHADSLIYHGSPHGVQRAFLRTLCADIVHTDSGTEAQARRINEYGTKGIRARRITKDDQKLICKWLLRLKDLQPGFVDHHLAIEDMFKDLGDLDSPASADLAASIDTAIRSASVRRSFFITDKGYIGLGPAKMGVGDDLYIVLGCRTPLILRRGSATPTQGQLPWPVYYVIGDCYAHGLMDGEAMETWRKFFLENETNARFRGRVHLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q7Z1</accession>
    <name>A0A3D8Q7Z1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_12581</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q7Z1"/>
    <dbReference type="OrthoDB" id="3897607at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF167">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="104"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="40"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="379"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW57780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="425" mass="46464" checksum="0D7E6353073AE705" modified="2019-01-16" version="1">MTALNHAVIVPRVDLTANNAPKIIIINAIFTGVALLVIIARMYVRIAMLKTVGADDYIIMSSMVMQSLQSFENSSSLHLIDPGKNGTGSWITKFRASANYQSQALGVGVLICVIGECYWGKGRHVLAILPVNMVKLLHWQFFHSILVTIGISLVKISLASFLSRLVTNKIIKRFLIGVIIFLVLFTISSAGTIIFSCIPVSSTWDPAAAPNAKCFSRTTFTDIGLFNSIVNISTDVMFACLPIPIVWNLQLNTRTRVTLVGVLSLGFFACACAIVKTVLQSHFYSNTDFTFTDSYFIWNNIELSVGIIGASLPALRPLFASLLESTKDFATRRTGLGSSSNAHRRYYAHIDRIGMESIPRTRDTANNYNVTVSSRGALGERGSEEDITGTWHGHNSSEDKLPLPRAADVGSGNPVIIKTIDVRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q972</accession>
    <name>A0A3D8Q972_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptidase S58 DmpA biosynthesis protein ArgJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_12306</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S58 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q972"/>
    <dbReference type="OrthoDB" id="2107894at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.70.12">
        <property type="entry name" value="L-amino peptidase D-ALA esterase/amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016117">
        <property type="entry name" value="ArgJ-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005321">
        <property type="entry name" value="Peptidase_S58_DmpA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36512:SF3">
        <property type="entry name" value="BLR5678 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36512">
        <property type="entry name" value="D-AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03576">
        <property type="entry name" value="Peptidase_S58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56266">
        <property type="entry name" value="DmpA/ArgJ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="163"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW58376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="400" mass="43397" checksum="C43489100E47C998" modified="2019-01-16" version="1">MSSRIRDWGYAPGQFPTGPKNSVLDVPGVLVGQVDINEGEDVHTGVTVIFPRGIKNTIYTPCYAAVHDMNTAGEWTGIHQIREWGFTRAPIAFTNTISIGKVYDSIWRWTMRQLEADGITGLDQFEHYGFPTVGETFDGLLNEISRSAVEEVHVLEAMKRAESQTDVQEGNHGGGTGMRSHGFKAGTGTSSRLLKGDNGKTYTLGVIVQNNYGSPGDLQIDGVQIGKILWSKPGAKIEVPKPPESGKVSEGSCLVLIITDVPMLPHQLKRMAQRAGMGLSQVSGHGVGRNFSGEFFMALSTGNSPESPSKWDGMSSLPPFLETDTVETVKSQLIDTLFMAAAEATEEAVLNAMTSAKTLKGFQGFETKALPREEVEALLKKYGRGYMNEIFEANMAATTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q9K8</accession>
    <name>A0A3D8Q9K8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RmlC-like jelly roll fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_12280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q9K8"/>
    <dbReference type="OrthoDB" id="9970537at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025979">
        <property type="entry name" value="ChrR-like_cupin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12973">
        <property type="entry name" value="Cupin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ChrR-like cupin" evidence="2">
        <location>
            <begin position="25"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW58350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="127" mass="13991" checksum="6098E7A7CC1C6C57" modified="2019-01-16" version="1">MDQKEFSNPPPRPGPSASLNPESVKPWTSIGPGIWELVLNSAGDVEKSVLQWYEPGAKSVTDDIITHTYIEEVVYLEGGLKDVTLGQEWGPGAYAYRKPGMEHGPYIASSKGCYQFCKFTPVDNRQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QA17</accession>
    <name>A0A3D8QA17_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_12388</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QA17"/>
    <dbReference type="OrthoDB" id="5376287at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW58458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="53161" checksum="BE8A778655EB94DC" modified="2019-01-16" version="1">MAKSKYAAGLCFVPITPAQSQDKHTRKAIQSHATRAGARRRPLIELRPWINPHRELEPLEKAISKDTRASKSTSSIPSPRLVGADFSGIQLPPGIEPYMIQDLVKLMDLNRHGVYPYEICLDVHPTAKGWFPYLISDVCCLHSMMFSVRAFLERTEHNQPSPLAAFHYTQTLHLLQARLNGSDPTSAISDATMMVVISLATAAELTNDFAAVANHLQGLEKMVKVCRADLEYALLLGHRPRLLQEGISWDCFIADRGLIRCGHPPHDANLRTFAEMTMDVKLHNALRDLHAFSCVSNLAYQTTRKLSPDVYNEMMISILYRLTNLSFGRNPLAEVIRIGLLAFSSTIFIERHFMGQPSQHLLNLYTDALFNLRNSMNVDLPIPMVLWLTMFSHLVVHTELSPADWRSVWLDEAVLHGKINTWPQACEILRSVAWVDFIHSGTGKHIFEAAISRTARSDLMSKRASLPNRSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QB20</accession>
    <name>A0A3D8QB20_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_11966</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QB20"/>
    <dbReference type="OrthoDB" id="444631at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF92">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="100"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="27"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW59042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="365" mass="39943" checksum="F888D6C5E2AF34ED" modified="2019-01-16" version="1">MVADLSGPTVMGLEWALFTLAVIMVAIRLFVRIRIQRRKLLLSDAFLVISVIDAMALIICDTQSYRLGAMGGSAFTSADSGAAELQQIVTLSKYSFASNYFYDSGIYFPKFTILTFYLKLFPVTKPRLRKALYAVSAFTVSAFVCTAFLDTFWCGSDVASNWSTDAHACSTFNSLVVFQIDWSTNITSDVMIFLLPFPLLRELKLKPRQIIGLAVTFALGAITMAISIARFISVQASSLYNTLYVWSMAEMAVAIIVVSLPALSSLLNRRGQASTTQSYKLNSHYASASGLGSRAAHQKLGSITSGTFSASRSMGHLADENGSDVELNPAKGDPNGIYKRQEVTVESQVLESKEHRASAAYWESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QBM8</accession>
    <name>A0A3D8QBM8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_12055</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QBM8"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017711321" description="Thioredoxin domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="16"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW59131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="159" mass="16925" checksum="0359A0279AA985B6" modified="2019-01-16" version="1">METSIYVILALLAIFIIGPALFTDRSPIPETSGNVFKITKAAELDALLSSTTNVVVDFYADWCPPCRAIAPVFSKLADSHAVSGQLAFAKVNVDHVKDVAGRYTVTAMPTFVFFEKGKPTPVKAQGVNDGDDRIRGANPKALTAVVLALAKAAKSESEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QC90</accession>
    <name>A0A3D8QC90_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_12142</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QC90"/>
    <dbReference type="OrthoDB" id="16820at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF242">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="6"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW59218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="425" mass="47134" checksum="45D85B4120E0105A" modified="2019-01-16" version="1">MSTQKLKVVIVGGGIGELSAAIAIQIAGHNVTVLEAEEEINEVGAGLQFSANATRILIKWGLDKSIMKDVVEPYNCIMKRWEDGKIISKLPLHDYHREAYGAPFWDIHRHDLIKTLYQRALELGADIRVNSKVVDIEFESGTVILHDGQVFQGDLVVGADGLNSTCRKKLVPTETPEYTGDMAFRVLLNLADLAPNDPDFIEMATKPQCTYWLGPNGHAIVYILKGGKQINLVAVAPDDLPAGVIRAPCSVADVFKHFKNWDPLLQKIISQVPVIYKWKLHKRPELNKWNHPCGRFTLLGDAVHPTLPYLSQGAGISLEDAAVLGQVLTEPISLSQALTKYEELRRPRTTKIVKAATQQQYWYHLADGEAQKERDAIMGAEVSCIGDPFLWREPVFAPWLYGYDAYEEAHKAAGKSSAFANGNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QE04</accession>
    <name>A0A3D8QE04_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="6">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_11679</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 6">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="6">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="6"/>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QE04"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF1">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="4 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017733165" description="AA9 family lytic polysaccharide monooxygenase" evidence="7">
        <location>
            <begin position="20"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="8">
        <location>
            <begin position="20"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW60073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="328" mass="32797" checksum="0103E7C589CA8326" modified="2019-01-16" version="1">MLFKSSAVIAASLATVVSAHQNFHQFWVDGVSPGYQVAIRMPPSNSPVTNVSSDDIACNVNGQNVPSGVSTATAAAGANFTVQWDSSSHPGPIQHFLFGPVTNASMATGVGSWVKIDEWDETNDTFASNIMEENGMKYSFNLPTNIANGDYLLRSEMLALHGSQTLGGGQFYIGCAQITITGGVDGESCSPDIQLPGSYNESDPSIYIPDFYYGFNITTYTGPGGAVATCGTGSGSSSSPATATAAATTAVSSSAAVATSSAAVAAVAASSSSSAATSVTIPTTSGGVQVSTAASVTPTTLQTVAATSTSAVAASSAAAAAADDTCDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QEM7</accession>
    <name>A0A3D8QEM7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">uS12 prolyl 3,4-dihydroxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BP5796_11767</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>[ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3,4-dihydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54160"/>
            <dbReference type="Rhea" id="RHEA-COMP:13817"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
            <dbReference type="ChEBI" id="CHEBI:138052"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[ribosomal protein uS12]-L-proline + 2-oxoglutarate + O2 = [ribosomal protein uS12]-(3S)-3-hydroxy-L-proline + succinate + CO2</text>
            <dbReference type="Rhea" id="RHEA:54156"/>
            <dbReference type="Rhea" id="RHEA-COMP:13816"/>
            <dbReference type="Rhea" id="RHEA-COMP:13818"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:50342"/>
            <dbReference type="ChEBI" id="CHEBI:85428"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TPA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QEM7"/>
    <dbReference type="OrthoDB" id="430522at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031543">
        <property type="term" value="F:peptidyl-proline dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009896">
        <property type="term" value="P:positive regulation of catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010604">
        <property type="term" value="P:positive regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006449">
        <property type="term" value="P:regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000014">
        <property type="entry name" value="Prolyl 3,4-dihydroxylase TPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.20">
        <property type="entry name" value="Oxoglutarate/iron-dependent oxygenase, C-terminal degradation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019601">
        <property type="entry name" value="Oxoglutarate/Fe-dep_Oase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043044">
        <property type="entry name" value="TPA1/Ofd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039558">
        <property type="entry name" value="TPA1/OFD1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051842">
        <property type="entry name" value="uS12_prolyl_hydroxylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12117:SF0">
        <property type="entry name" value="PROLYL 3-HYDROXYLASE OGFOD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13661">
        <property type="entry name" value="2OG-FeII_Oxy_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10637">
        <property type="entry name" value="Ofd1_CTDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0847">Vitamin C</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="14">
        <location>
            <begin position="146"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="479"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="640"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="496"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="510"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="533"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00051966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00081607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDW60161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="660" mass="73503" checksum="24104BE02C485795" modified="2019-01-16" version="1">MKRKADAQLSAANGKSAIKKRAKTVLSEEDRKNSFRKGLFAEDVLSKYTQDYAKSEPYKHSVINSLIDDALLRKVRDEIRENVSFTPKETDIYKIHQSGDLANLDGLDDAALEKLPSLLRLRDSLYSSSFRKYVSTITGSGELSGKKTDMAINVYTPGCQLLCHDDVIGSRRISYILYLTDPDIPWKAEWGGALRLFPTTSHKEENGETTKTPSPDVSKVIPPAWNQLSFFAVQPGESFHDVEEVFHAQSEEQLEKEGGRIRMAISGWFHIPQPGEEGYVKGAEEKLAANSSLMQLQGNPDSYDFPQQQIVTIEAPAEPAEENGLEASDIDFLLKYMAPTYLTPDTLEQVSEHFAEESSVTLDSLLSKKFSEKVRAHVTAQEAAGLPEKSSDIEQTTPWKVARPPHKHRFLYQQTTTTSPDPSRELDPVQEILEVLLPSRQFHKWLSIATECEIENYDVLARRFRKGCDYILATSHDGNPRLEINLGLTPTSGWGADDEDEEDAEEEEAENAKTAKTVKTDKAKGKDKKNAEPEPEPEEDDDVGGHEVWMAADDDAADAAIYKASTGEEDDNVLFAMPASWNKMSIVLRDSGVLRFVKYVSRNAKGDRWDVGGTFDVKDLEDDEEVGGDGEDEAALGILEETSEEEVFNGFPDSSDGESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QFS2</accession>
    <name>A0A3D8QFS2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RBR-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_11870</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.31"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.31" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QFS2"/>
    <dbReference type="OrthoDB" id="9977870at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20335">
        <property type="entry name" value="BRcat_RBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22584">
        <property type="entry name" value="Rcat_RBR_unk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031127">
        <property type="entry name" value="E3_UB_ligase_RBR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002867">
        <property type="entry name" value="IBR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044066">
        <property type="entry name" value="TRIAD_supradom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11685">
        <property type="entry name" value="RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01485">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00647">
        <property type="entry name" value="IBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51873">
        <property type="entry name" value="TRIAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="333"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="66"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="160"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="266"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="544"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="89"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="187"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW60264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="804" mass="90386" checksum="EAE94DD9F2298829" modified="2019-01-16" version="1">MASTSRLRSPWPSTTGNIAYENYSYAPIDIASSSSGLPTFKITGTNPNEIPRTIPDTWLGVTERLATQPSVPKRPAPHPKSLSSDKRATSQVQIPATGGNQSIPRDYTIAEPRYFLVSEVSSQADRSRSQQPPENNDDELFFDAPTVILQDDSVTVTGSVAQESHGNALQRPDQNNADNNRRPLAQRSGQRTSPARINVSNDPLNAAQAVNWRDLDAPQELIHSNEATSQDIKDLLKPSIARVADQHVQPLELEEPVTYYTASNSASASSLDSGYGSATPEPEKKSKGKKALGGLASLFRRKDGRGAFSVTDAIGSSSTGMVTAFPPVWPSAPIIERKPLAVTNTISSTSAPAVVPESSQESLIFTALTSEAQWPPKCCLNPIPSATIIKHLPADLIDKYETKDMELSTPAAERVYCSRANCNLWIPPKNISKASSLAKCSTCKQKTCSICRGEAHNGQDCPDDPSLRATDTLAEVEGWKKCYSCHAYVEHNTGCRHMTCRCKAEFCYVCGLRWRTCGCSESDLAVVRTRNLARHEAAAAAMARDDAAAMRDAEERELVRLVEEFEREEAERQAREAEQERIEAARRAEEQRRRIEEQRISRVHFQFANFRTELESLHAIQQVLLAERHEFKEDCLRREYENEKESLTLRSTIQEQLFRAESQSRLSDANYRLNREYQARLAEGRKSDETYYQALVTHNKGKEGADERVRTLFQERIAEEQKNFETWYKVRQAQLSALAETESRKMAQLSQAQKLERQKIEKDHFEKRELWTQRCDADVHWVDAVIAERERMLNSMEQEEYARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QIA3</accession>
    <name>A0A3D8QIA3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_11292</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QIA3"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF102">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW61400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="373" mass="41895" checksum="11F957C4AD3D2153" modified="2019-01-16" version="1">MHLEAQNQDTSARDEKPESEILNKQIPGTSADIDRHDTQSKNSSSPSRTPVDRASPEEADNTLDTDNDSAIGDLGSYATSTYTVGSGLEDNIKENGRTYHVYKDGTNSASEKDIQHKMWLITLENKLHLAPISSTPHNVLDLATGTGIWAIDFADAFPTANVTGTDLSLIQPSYVPPNCRFEIDDVEDEWLFSNKFDYIHGRALATCFNDGASVVRKAYDALEPGGWFELQDFELQKSDDDSMKGTNFEAMEGHISEAMKKLGRTTWGGNVPNYARWFREAGFEGVTETQFRWPSNPHWPTSRKEKLLGAWWQVQIEAGLLESLSTRIYLNVLGWTKEELTVFLAMVRNEENDPNIRAYVPVHIVYGQKPLEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QIS0</accession>
    <name>A0A3D8QIS0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Utp21-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_11500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QIS0"/>
    <dbReference type="OrthoDB" id="10250769at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000565">
        <property type="entry name" value="Putative snoRNA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059157">
        <property type="entry name" value="WDR36-Utp21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007319">
        <property type="entry name" value="WDR36/Utp21_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840:SF12">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25171">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25168">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04192">
        <property type="entry name" value="Utp21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR36/Utp21 N-terminal" evidence="6">
        <location>
            <begin position="63"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="611"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="696"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="WDR36/Utp21 C-terminal" evidence="5">
        <location>
            <begin position="826"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="792"/>
            <end position="816"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW61608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1036" mass="113093" checksum="2C21677BA3520C94" modified="2019-01-16" version="1">MPSSIPAQREGPVVKRQKLNSVDRSKTVSRESRIFTPFRTIGLVSSTTVPFTSIPLGKTSFQITTSVGRCLETYDLKRGLNLVFLTRPQTPEDISATVAWKDRVFAAWGGSKQGGSQGLWVFKRGKKTEELVMPPDLDQPIKQVLIFGTWIVACCTTRIEIWKSATYEHYTTLFSTTVQKGGNELTGGICTMPTYLNKIFAGRKDGGVEIWNVNSGKLIYTVLPPGPKCGAVTALQPTPALSLLAIAYSEGPLVIQDIRRDKTVIHLNSSQSQVTSISFRTDEMGAGDDGRKAGVMATAGTETGDVTFWDLNEGGRVMGILRGAHNPPAHADAIVGGGISKVEFLPGQPVIVTSGLDNSLKSWIFDETPYSPVPRILHSRSGHAAPVTQLQWLPTDADGADAGGKWLLSAGKDRSLWGWSLRRDGQSTELSQGNIRKKARKMGILANVSLANEPSMTLEDLKAPEITCMASSLNRDGGMGANPGSGAVWQKGSNATKKQTDATQSGVTGWESVVTGHQDDKFARTWFWGRKKAGRWALETGDGGNVSTVTISPCGTFAVVGSELGGIDMFNLQSGLHRQRYPSKLTPAQARKLKIQMLDGTKPLSGFQPGLGKHTKAVTGIMVDSMNKNIISCSLDGKVKFWDFMTGNLVDEINWHPMAAIKDLRYHAPSDLIALTCDDLSIRVVDIETKKTIRELWGCQGAINDICFSNDGRWIIAAGRDCIIRVWDLPTGHMIDAIRTETPCTALAFSGTGEFLATTCEGQVGVNIWNNKTLFTHVPTRHISENEIAEISGPTVSGEGGQGVIDGAFEDDNEDVEDSAPMQSLDQLSTDMMTLSLVPKSKWQTLLHLDLIKQRNKPTEAPKLPEKAPFFLPSLEKPLPLTKAEEEKAVENIAEKSRIMKMDRFSSEGAFTVALRAGSESGDYTAFVDHLKTLSPSAADLEIRSLNPGEGDVESDELVNFVDALTSRLVQKRDYELVQAWMTVFLRLHSETITHDDRLVEALRLWKQHQESEGARLGDLVGYCSGVVAFMRNPRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLE3</accession>
    <name>A0A3D8QLE3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_10782</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLE3"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="9"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW62480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="444" mass="49474" checksum="534C8A903586B711" modified="2019-01-16" version="1">MGKTTHDEFHVAIVGAGIGGLALAMALHKKGISFTLYEEAKEYSAVGAGIGFAPNGMRTMDLIEPGFRPLYEEVCVGNKGEKAQDIFFEGLLIKEGLGCDEKWVGKSAWGHPDYVRKSAHRKTLLDIMTSFIPIESVKFSKRLTNIEQRSDGVILTFSDGTIAESTILAGADGITSTVREHVLKDMYPSQVAPVYAGAYCYRAVIPMSEAYEVLGDLTDVAKFYFGLKRSAVTYRITGGDEFNFLLCVADSEDAWKLKEAVTEKITHEAMMADFKGPGVDERFRQLLSKAQPTKWGFFHHLQTSTYYRDRVVLIGDSAHASLPFQAAGAGQGLEDALVLSNVLAQLAKLPQRGTSQTRSIHAGLAAYDSVRRPRAQKQLEQAAEVGRMIFFQHEEAGDHMDKILPRLQQGRFNWLWFHDMNKDVQEALYRMQRQINASRYTARI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLJ9</accession>
    <name>A0A3D8QLJ9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal RNA-processing protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_10890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLJ9"/>
    <dbReference type="OrthoDB" id="5390at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12293">
        <property type="entry name" value="dRRM_Rrp7p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12950">
        <property type="entry name" value="RRP7_Rrp7p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040447">
        <property type="entry name" value="RRM_Rrp7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040446">
        <property type="entry name" value="RRP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024326">
        <property type="entry name" value="RRP7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 7 HOMOLOG A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17799">
        <property type="entry name" value="RRM_Rrp7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12923">
        <property type="entry name" value="RRP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rrp7 RRM-like N-terminal" evidence="4">
        <location>
            <begin position="9"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA-processing protein 7 C-terminal" evidence="3">
        <location>
            <begin position="188"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="227"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW62588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="34975" checksum="14ADF851A6DC2CEA" modified="2019-01-16" version="1">MSQIPSTIADYAVLPIAIPPTPAYQVKTTHHVYVRPHAPKLPTVDDSRSLFLVNVPVDSTSPHFRAVFASLVGAGRFESITFESERKNAPSSAILAIEATRGKKRKRASEADVELDTGLPQTWDRALHKSGSTAIAVFADEKSAEAVLKAIKKLHKSGKGAFPVWGEGLTEKVPKLGSHRYLTHHKMQYPDPDLLRASVDAYMMEFNRKEEEASQMAKRMRNVPDEDGFVTVTRGGRSGPARRDDAETKRLELEEKEEKKRKEMGDFYRFQLRERRKEEQGELVKRFEEDRKRVDAMKEKRGKFRPET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QM42</accession>
    <name>A0A3D8QM42_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_11022</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QM42"/>
    <dbReference type="OrthoDB" id="3565203at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW62720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="219" mass="25098" checksum="07742BC2DDEA2DF6" modified="2019-01-16" version="1">MVILGGLEVLAAGYLLHKHNKNKRERARLEEEAAALEEQQYQILPPEHHGRRHNSHDRKHSYERRHSHSRDRKHSRHRQDHHAGPSQSVPPPQYVAAVPPQYPVQQQPNNSQFFPPPPPPNPPVPQQQQGAYYPPTGIPAHWEQKAQSTGGSQTHQMKYGFYDGQEHAPRGRSDHRDVLAMRGGEGSARRSTDSERQRVRFADERDSMRSPPPRYSDAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QME9</accession>
    <name>A0A3D8QME9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small-subunit processome Utp12 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_11170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UTP5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QME9"/>
    <dbReference type="OrthoDB" id="30195at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007148">
        <property type="entry name" value="SSU_processome_Utp12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052414">
        <property type="entry name" value="U3_snoRNA-assoc_WDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04003">
        <property type="entry name" value="Utp12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small-subunit processome Utp12" evidence="5">
        <location>
            <begin position="158"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="34"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="314"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="65"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="314"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="335"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW62868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="400" mass="42900" checksum="6C52828B98590231" modified="2019-01-16" version="1">MSTKRKISTKLGQPMVKPSAKAVGKAFVDESRTVATTGHAVSTNGFKDGEVVDISSDSSSNDSDHSDDDVAASEPDDAGEEDVAMGDTQEAGEGEDTEGAAEPSFGDLVRANAAEPIDVAGAFDDPSTGALSYPQGARLQAPTGASLGTVLSQALKTNDISLLESCLQVSDTKTIRSTIQRLDSPLAGTLLQKLAERIHRRPGRSGSLMVWVQWTLVTHGGYLATQPNLVKKLSQLNRVLDDRSRSINNLLSLKGKLDMLEAQIELRRSMQKGQQGFDEEEDEEDVIYVEGQEDEDEESAMNSALERMARNGELDDFSGSEDSEDMPMVNGAVADSEDDEESEDGDMIDDEAEETDADSGDEDEVDHEDMDSQGESDSDAAAAPPTKLQRIGGMFSRGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQ35</accession>
    <name>A0A3D8QQ35_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_10417</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW63915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQ35"/>
    <dbReference type="OrthoDB" id="5378975at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031355">
        <property type="entry name" value="YBL010C/LAA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38698">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38698:SF1">
        <property type="entry name" value="FUNGAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17104">
        <property type="entry name" value="YBL010C_LAA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="264"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW63915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="550" mass="59718" checksum="982840B2C8D86774" modified="2019-01-16" version="1">MAPDDHSTLEPPRTSVDDPGAHDLESEESSDDHFSDARSGLEHSALNSPIGIPVTRVEKVDGEPSYGEVPGTEAFKMRTGDAIPDEIALVTDVRDADLDTTYDDARPTTPGGRPIPITVVERVDETVSYGEVPGTAAHEMRAADAVPDMVVRGSAHNSRSSSISSPISRARAGSTPGDLPIPITRVEKVDDKPSFGEVPGTEAYEKRKEDAEPDVVDKVGDLPVSPTSPGVRRSSFLSHSRRKSSGASQRFRRASLAPSINNDYNEEEDGSEGGFGDDFDDFEEGADDADFDDFDDGFQEVELTSPPPQSIPLVPSFSVLDFSELDSPEAIGSATEPYLDALFPADTIDTSILPPLPKDGNPIFLTQRSASLWSQLVAPPPLQPPNWIRSRIRRLFLVSLGVPVDLDEILPASKQKKLILPSIHLNPSSGSPRTSTDSRSISRLKNEDGNASSTSLDSQGKPSKRRRGAPSTPDLDLVSARQICTITDEAMNGMTMEELQEHAKRLKGMQETAEEVLAFWTKMTDEKLGDREAFEGVIENLVKHARKTRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQD3</accession>
    <name>A0A3D8QQD3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA-directed RNA polymerase III subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_10521</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC7 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQD3"/>
    <dbReference type="OrthoDB" id="5377312at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024661">
        <property type="entry name" value="RNA_pol_III_Rpc31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15367:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11705">
        <property type="entry name" value="RNA_pol_3_Rpc31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="128"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="212"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="336"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="154"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="341"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW64019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="44474" checksum="36ABB7457D204EDE" modified="2019-01-16" version="1">MSDLPPGDDNRGGGKDRLSSGYEDGCSPDAKLPRWMHAIKAQSINNKNNAIVNDVHQAFVEGYPARHGGQKVKDWMADAEWRPFLYPANFTAQNLAGMTFQRATPLEQLHPASGVESPRLDLPKPATRHFHKHKKQPGAKFQDHRSSSADMSRGGRGGARGGGVKGQTWDFDAEFKGDFTPSEKFPAYKVPIPAPVTEKERKEIKHYKDLQDQIHQGPLYTQPSKRDPNAPAKTYSEDQFNERYGVKSKADVDPFTGVPTYTQKYEQKKRVIPELSGRPFNKDFFPKELWDTLEGEEGDDVRAHINRIAKKKALMLSGQRTDLNPSEKAKALLEKIQNVAEEGDEDAEPGEEEAEEEDYDYEEDEDEMGGDYDGEQYFDGGENDEDDGDGGNGGDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQW9</accession>
    <name>A0A3D8QQW9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">L-lactate dehydrogenase (cytochrome)</fullName>
            <ecNumber evidence="15">1.1.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BP5796_10386</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(S)-lactate + 2 Fe(III)-[cytochrome c] = 2 Fe(II)-[cytochrome c] + pyruvate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:19909"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.1.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19910"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">In the C-terminal section; belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">In the N-terminal section; belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.2.3" evidence="15"/>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW63884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQW9"/>
    <dbReference type="OrthoDB" id="1925334at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004460">
        <property type="term" value="F:L-lactate dehydrogenase (cytochrome) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02922">
        <property type="entry name" value="FCB2_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000062">
        <property type="entry name" value="Cytochrome b2, mitochondrial, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.120.10:FF:000012">
        <property type="entry name" value="Mitochondrial cytochrome b2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000262">
        <property type="entry name" value="FMN-dep_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037396">
        <property type="entry name" value="FMN_HAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008259">
        <property type="entry name" value="FMN_hydac_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037458">
        <property type="entry name" value="L-MDH/L-LDH_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578:SF148">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE (CYTOCHROME)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10578">
        <property type="entry name" value="S -2-HYDROXY-ACID OXIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01070">
        <property type="entry name" value="FMN_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00363">
        <property type="entry name" value="CYTOCHROMEB5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01117">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00557">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51349">
        <property type="entry name" value="FMN_HYDROXY_ACID_DH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0288">FMN</keyword>
    <keyword evidence="5 17" id="KW-0349">Heme</keyword>
    <keyword evidence="10 17" id="KW-0408">Iron</keyword>
    <keyword evidence="8 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="18">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="FMN hydroxy acid dehydrogenase" evidence="19">
        <location>
            <begin position="104"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00061137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00061589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00066458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00068515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RDW63884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="497" mass="55417" checksum="66A3A8C5A60A8C8D" modified="2019-01-16" version="1">MPSLTGADIAKHNSKESCWVILHGNAYDVTEFLPEHPGGPKIILKYAGKDATEEFEPIHPPDTLDKYLDQSKHLGPVDMDTVEQDEKAEDPAEIERQDRIARMPILEQCYNLMDFEAVARNVMKKTAWAYYSSGADDEITMRENHSAFHKIWFRPKILVDVEKVDFSTTMLGTKVDLPMYVTATALGKLGHHEGEVLLTRAAKKHNVVQMIPTLASCSFDEIMDAAEGDQVQWMQLYVNKDRSITKKIIQHAEKRGCKGLFITVDAPQLGRREKDMRVKFDDVGSNVQSSSGEETDKSQGAARAISSFIDPSLSWKDIPWFKSITKMPIILKGVQRVEDVIRAVECGVQGVVLSNHGGRQLDFARSGIEVLAEVMPVLRERGWENRIEIYIDGGVRRATDIIKALCLGAKGVGIGRPFLYAMSAYGLPGVDRAIQLLKDEMEMNMRLIGCTSVDQLNPTLVDTRGLSMHTTSVPSDTLGLSVYDPLINPSLKEKSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQZ9</accession>
    <name>A0A3D8QQZ9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="27">Fatty acid synthase subunit beta</fullName>
            <ecNumber evidence="5">1.3.1.9</ecNumber>
            <ecNumber evidence="7">2.3.1.38</ecNumber>
            <ecNumber evidence="8">2.3.1.39</ecNumber>
            <ecNumber evidence="4">2.3.1.86</ecNumber>
            <ecNumber evidence="3">3.1.2.14</ecNumber>
            <ecNumber evidence="6">4.2.1.59</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="32" type="ORF">BP5796_10572</name>
    </gene>
    <organism evidence="32 33">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="32 33" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="32 33">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="26">Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for: [acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>(9Z)-octadecenoyl-[ACP] + H2O = (9Z)-octadecenoate + holo-[ACP] + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15057"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="Rhea" id="RHEA-COMP:9924"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30823"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78783"/>
            <dbReference type="EC" id="3.1.2.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a (3R)-hydroxyacyl-[ACP] = a (2E)-enoyl-[ACP] + H2O</text>
            <dbReference type="Rhea" id="RHEA:13097"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="4.2.1.59"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>a 2,3-saturated acyl-[ACP] + NAD(+) = a (2E)-enoyl-[ACP] + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10240"/>
            <dbReference type="Rhea" id="RHEA-COMP:9925"/>
            <dbReference type="Rhea" id="RHEA-COMP:9926"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:78784"/>
            <dbReference type="ChEBI" id="CHEBI:78785"/>
            <dbReference type="EC" id="1.3.1.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>acetyl-CoA + n malonyl-CoA + 2n NADPH + 4n H(+) = a long-chain-acyl-CoA + n CoA + n CO2 + 2n NADP(+).</text>
            <dbReference type="EC" id="2.3.1.86"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="25">
            <text>holo-[ACP] + acetyl-CoA = acetyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41788"/>
            <dbReference type="Rhea" id="RHEA-COMP:9621"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78446"/>
            <dbReference type="EC" id="2.3.1.38"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>holo-[ACP] + malonyl-CoA = malonyl-[ACP] + CoA</text>
            <dbReference type="Rhea" id="RHEA:41792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9623"/>
            <dbReference type="Rhea" id="RHEA-COMP:9685"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:64479"/>
            <dbReference type="ChEBI" id="CHEBI:78449"/>
            <dbReference type="EC" id="2.3.1.39"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="20">[Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta).</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 28">Belongs to the fungal fatty acid synthetase subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="32">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.9" evidence="5"/>
    <dbReference type="EC" id="2.3.1.38" evidence="7"/>
    <dbReference type="EC" id="2.3.1.39" evidence="8"/>
    <dbReference type="EC" id="2.3.1.86" evidence="4"/>
    <dbReference type="EC" id="3.1.2.14" evidence="3"/>
    <dbReference type="EC" id="4.2.1.59" evidence="6"/>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5417908at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005835">
        <property type="term" value="C:fatty acid synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019171">
        <property type="term" value="F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004313">
        <property type="term" value="F:[acyl-carrier-protein] S-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004314">
        <property type="term" value="F:[acyl-carrier-protein] S-malonyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004318">
        <property type="term" value="F:enoyl-[acyl-carrier-protein] reductase (NADH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016297">
        <property type="term" value="F:fatty acyl-[ACP] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004321">
        <property type="term" value="F:fatty-acyl-CoA synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03447">
        <property type="entry name" value="FAS_MaoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.120:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.70:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000017">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000078">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.100:FF:000001">
        <property type="entry name" value="Fatty acid synthase beta subunit dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000015">
        <property type="entry name" value="Fatty acid synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2430:FF:000001">
        <property type="entry name" value="Fatty acid synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000003">
        <property type="entry name" value="Fatty acid synthase subunit beta dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1400">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.60.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039569">
        <property type="entry name" value="FAS1-like_DH_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016452">
        <property type="entry name" value="Fas1/AflB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013565">
        <property type="entry name" value="Fas1/AflB-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041099">
        <property type="entry name" value="FAS1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040883">
        <property type="entry name" value="FAS_meander"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003965">
        <property type="entry name" value="Fatty_acid_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050830">
        <property type="entry name" value="Fungal_FAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002539">
        <property type="entry name" value="MaoC-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032088">
        <property type="entry name" value="SAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982:SF21">
        <property type="entry name" value="FATTY ACID SYNTHASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10982">
        <property type="entry name" value="MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08354">
        <property type="entry name" value="Fas1-AflB-like_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13452">
        <property type="entry name" value="FAS1_DH_region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22235">
        <property type="entry name" value="FAS1_thioest_ins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17951">
        <property type="entry name" value="FAS_meander"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17828">
        <property type="entry name" value="FAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01575">
        <property type="entry name" value="MaoC_dehydratas"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16073">
        <property type="entry name" value="SAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005562">
        <property type="entry name" value="FAS_yeast_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01483">
        <property type="entry name" value="FASYNTHASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="11 28" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="18" id="KW-0456">Lyase</keyword>
    <keyword evidence="19" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="15 28" id="KW-0520">NAD</keyword>
    <keyword evidence="13 28" id="KW-0521">NADP</keyword>
    <keyword evidence="14 28" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="33" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 28" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Malonyl-CoA:ACP transacylase (MAT)" evidence="31">
        <location>
            <begin position="1692"/>
            <end position="1992"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="30">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="30">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="30">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="active site" description="For acetyltransferase activity" evidence="29">
        <location>
            <position position="286"/>
        </location>
    </feature>
    <feature type="active site" description="For malonyltransferase activity" evidence="29">
        <location>
            <position position="1836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012996"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00013258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00033756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00048237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00048536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00048572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00048835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00058855"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00068309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="PIRNR" id="PIRNR005562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="PIRSR" id="PIRSR005562-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="SMART" id="SM00827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="32">
        <source>
            <dbReference type="EMBL" id="RDW64070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="2092" mass="231802" checksum="C0F795B02895AA8C" modified="2019-01-16" version="1">MYGTSTGPQTGVSTPRSSSSLRPLVLTHGSLEHSFLIPTSLHFHASQIKDRFLASLPAPTDELAQDDEPSSVAELVARYLGFVADEVEEGEDDAQGSYEEVLKIVLNEFERGFLRGNEVHALVATLPGIDAKRLEVVRSYYSARAALQRPIRAHESALFRAASDEKAKIYSVFGGQGNIEEYFDELRELYKTYPAFIEPMITSSAELLQNLSRDPRAEKLYSKGLDVMTWLHDPESTPDVDYMVSAPVSFPLIGLVQFAHYSVTCKVLGLTPGQFRERISGTTGHSQGVVLAAATSAADSWESFEKIATASLTILFWIGSRSQQAYPRTSLAPSVLQDSVDNGEGTPTPMLSIRDLSQEEILKHIAATNQYLPEDRHIAISLINSARNVVVTGPPISLYGLNLQLRKVKAPTGLDQTRIPFTERKVRFVNRFLPITSPFHSQYLKEATANINEDLKDIKIDGKTLAIPVYDTMTGKDIREEGGNIVPTLVRLITHDQVNWEKATVFPGATHILDFGPGGISGLGVLTSRNKDGTGVRVILAGAIDGTVPEVGYKPEMFDRDEEHAVKYAIDWVKEHGPRLIKTTSGQTFVDTKMSRVLGVPPVMVAGMTPCTVPWDFVAATMNAGYQVELAGGGYYNAKTMTEALTKVENAIPAGRGITVNLIYVNPRAMQWQIPLLGQLRAEGVPIEGLTIGAGVPSIEVAQEYIETLGLKHIAFKPGSVEAIQAVINIAKANPTFPVILQWTGGRGGGHHSFEDFHQPILQMYGRIRRSENLILVAGSGFGGAEDTYPYLTGTWSGKFGYPPMPFDGCLFGSRVMTAKEAHTSKNAKKAITEAEGLDDSQWEKTYKGPAGGVITVRSEMGEPIHKLATRGVKFWAEMDAKIFSLPKEKRVAELKKQRAYIIKKLNDDFQKVWFGRNKAGETVDLEDMTYGEVVRRMVDLMYVKHESRWIDKSYEKLTGDFIRRVEERFTPGQGKPSLLQSYSELDDPYPTVERIMSAYPEAEVQLINAQDVQHFLMLCQRRGQKPTTFVPVLDENFEFFFKKDSLWQSEDLEAVIGQDVGRTCILQGPTAVKYSKLVDEPIKDILDGVHNAHIKGLTQDIYGGDESTIPVVEYFGGKLIESPTEVNVEGLTISEDANKETYRLSTAATATLPSLESWLSLLAGPKRSWRHALFTSEVIVQGQKFQTNPMKRIFAPVRGLFVEIENSGDSSKTIITVKEQPRPNHYVTVIEVKMVGKNEILVNMIKDTTALGKPVALPLKFTYHPEAGYAPIREVMEDRNDRIKEFYWRAWFGNEALNLDASVTGQFNGGKATITSEAINDFVHAVGNTGEAFVDRPGKEVFAPMDFAIVVGWKAITKPIFPRTIDGDLLKLVHLSNGFRMLPGAEPLRKGDEVETTAQINAVINQDSGKMVEVCGTITRDGEPVMEVTSQFLYRGAYTDFENTFQRKNETPMQIHLATSKDVAVLRSKEWFSLDEPDHELLGQTLIFRLQSLVRFKNKTVFSSVETRGQVLLELPTKEIIQVASVEYEAGVSHGNPVVDYLERHGSSIEQPINFENAIPLSGKTPLLLRAPASNETYARVSGDYNPIHVSRVFSSYASLPGTITHGMYSSAAVRSLVETWAAENNVGRVRSFHASLTGMVLPNDDIEVKLQHVGMVAGRKIIKVEASNKETEDKVLIGEAEVEQPVSAYVFTGQGSQEQGMGMELYASSPVAKEVWDRADKHFMDNYGFAITNIVKNNPKELTIYFGGPRGKAIRQNYMAMTFETVTADGTTKSEKIFKEIDEKTTSYTYRSPTGLLSATQFTQPALTLMEKASFEDMRSKGLVQRDSSFAGHSLGEYSALAALADVMPIESLVSVVFYRGLTMQVAVERDATGRSNYSMCAVNPSRIGKTFNEQALQYVVENIAEETGWLLEIVNYNIANMQYVCAGDLRALDTLTGVTNYLKVQKIDIQQLMQTMSLDDVKAHLVEIIQGCAKQTEEKPTPLDLARGFATIPLKGIDVPFHSTFLRSGVKPFRSFLLKKINKTTIDPSKLIGKYIPNVTARPFELTKEYFEDVYRLTNSPRIGHVLANWEKYNSPQTNGVNGVEGAHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QRC4</accession>
    <name>A0A3D8QRC4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">S-adenosyl-L-methionine-dependent methyltransferase-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_10692</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QRC4"/>
    <dbReference type="OrthoDB" id="2877at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000017">
        <property type="entry name" value="probable 18S rRNA (Guanine-N(7))-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039769">
        <property type="entry name" value="Bud23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022238">
        <property type="entry name" value="Bud23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734:SF0">
        <property type="entry name" value="18S RRNA (GUANINE-N(7))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12589">
        <property type="entry name" value="WBS_methylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="10">
        <location>
            <begin position="52"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 C-terminal" evidence="11">
        <location>
            <begin position="214"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF12589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW64190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="281" mass="30258" checksum="38C4F6E5E0E01BE6" modified="2019-01-16" version="1">MSRPEDTLPPDLHYNDTEARKYTTSSRIQNIQASMTNRALELLDLDTPSMILDIGCGSGLSGEILSSVDPSEGGPHIWVGMDISASMLDIALQRDVEGDLMLADIGQGVPFRAGSFDAAISISAIQWLCNAESSEVSSTGRLSRFFNGLYASLKRGGRAVCQFYPKNDLQRTMISGAAIKAGFGAGILEDDPGTKNAKLYLVLTVGGSANEGDSGDITGVVKGMEGVDVLDARRKHKEKGRKEMKKGSKAWINHKKAQMEAKGKVVKHSSKYTGRSRNIAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QTT2</accession>
    <name>A0A3D8QTT2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_09891</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QTT2"/>
    <dbReference type="OrthoDB" id="5979581at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053235">
        <property type="entry name" value="Ser_Thr_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361">
        <property type="entry name" value="MITOGEN-ACTIVATED KINASE KINASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24361:SF433">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FHA" evidence="11">
        <location>
            <begin position="126"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="254"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="72"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="72"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW65199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="543" mass="60823" checksum="D09F0A6F57D580BE" modified="2019-01-16" version="1">MPREANDPVNLAGEDRLTDTVPFTRFASPSRFEQARHDTPELSLEEQGIFARLRPLNKNARRAFKALKAKAQDDDTAEEYKHHRQFIGTDSGVTDKADSADDGPAEDSDHYVLSIGLLPEFPTLGWRIGRGRNKLKNLGVDLLIPEGEGVAGVHARLCWMKGAGGFFIVAVNLRDGVDVFLNGEQLRNEQRLIPFQNGISIGECNFTLDFVQRSHEEEEQFQVELSAFYSKVMKENAPLMLPTPSGNEVRLGNWLVRNPIASGGFGRVSIVTHVHTGRAAAAKELWCTPRNSGNVHREVKMAEAIKDLKHKRLNLPFEIYHQKLKEANAQQARIEKLLDSSWSPGSSDTTDLYILYSPLSTGTFQALTRSRFSNKVYTPLFAQVLEGLAFLHDNGIAHRDIKPGNLTIRSYDPPDAQIIDFGCATFDNPILYSRYDRPGTIPYLAPEQVEGAKYCRDVDYWAAALVGIEIMGYSRPSLQVTAAIYDEIHAWLDQQKSDPIVLCCKEMLQFEPEKRLTAKQAVAKYFSSGINGAVTKRRRSELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QV60</accession>
    <name>A0A3D8QV60_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_10263</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QV60"/>
    <dbReference type="OrthoDB" id="3692311at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="648"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW65571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="764" mass="83443" checksum="E399B92FA146ABCA" modified="2019-01-16" version="1">MSSAKPFWPARRYKGLAICHCHTTPERSKELHNIWFSLVFVVTPMSERHAFVRTPTTPSFLGSPYERKLDASTHTDEFLIGGSESANEPWKLSAFESIRSFKYNPVFGGKSTTRAPTWSPQPKRLQRTALDWASLVFYNAMTYLVTFPFFALSAKVGLVNGKVTSPETLQRLQNTTKMAATVFPIAFALVVGRTMSKVAAWHLEKGARLQTLEQLMGSRTVFGAVRTQFMLSSYNLLALALVFIWAMSPLGGQATLRILETSTQQDIANSVVNYLDTTGPSSFQGTNSATVFLATLNGMYFSSLTAPNTVKSSSLDLWGNLKIPYLTSTGPDWVDVNATIDPSEYSSVLGIPLFNVIDGVSVFELESTYMQLDCTNVTAVIGDADVRVQFANTTTHAIGTLNGTFQGACCVDPNAPDCTASTSWCLGVNNFASSDYMWQRPAGLINITGEVPQTTLLYEDAPYNFGANTVAECQVTQRYVESSVSCNKTSALTSCAVVAQRESQLAHANSNLTWMSFSGVFDEISSLMPAATGSYQHSGMIDYTQKYVLNPNTSVIMTVDQETGNNTVIGDLDPQLIGKRLGQLFNAYYIGSIAPFTMNGDPELGQQVLQPNNATLANPVFTSITGENLINSVNASVTTESEIYKCSWRWLGILVVATLIMFVLAVVGTYYDVRRHTPEILGFCSTLTRDSKYVTQPGPGGSLLEGFERARWMKDVQLRFGDVYADGEAGLMAGEAGVDGEHVRSLGVAEVQMAARVRPGRLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QY73</accession>
    <name>A0A3D8QY73_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_09380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QY73"/>
    <dbReference type="OrthoDB" id="6509636at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016405">
        <property type="term" value="F:CoA-ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05911">
        <property type="entry name" value="Firefly_Luc_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.30:FF:000007">
        <property type="entry name" value="4-coumarate--CoA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF424">
        <property type="entry name" value="ACETYL-COA SYNTHETASE-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="2">
        <location>
            <begin position="31"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="3">
        <location>
            <begin position="462"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW66631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="562" mass="62493" checksum="37A1D3B0BD242C8D" modified="2019-01-16" version="1">MPSKSQLPWVPVHQSVPSFLFESPTATLPSTKPIIIDPKRPKTHYFTLHTLREWSKRLATGLVAAGFEAGDRVMLFSGNDLFTPVVVLGTLMAEGIYNSANPAYTPRELAHQLKDSEPKFILAADNCLDRALEAADLAGLSRSRVYLFETIQPGHENTAPQTSMVGNHWRSLISTPDAGEDFKWKELNTPELSNRTAILVYSSGTTGLPKGVELTHYNLISNARQLRQVQFTTDPSSRRALCCVPLYHGLGLVYYMIVAPSMGMQVYIMERYNLADMLDYIPKFKLTELLLVPPILIAMSKHIQTHQGKYNVDSIQKVIAGAAPIGMEITQDFEKIFSGRLNVRQGWGMSEALCITLCWHEQDPSKESSISVGKLLPGGEAMILNDKGVELPAGERGELWMRGPNVMKGYWKNPKATSDALTKDGWLRTGDIAYVDEDDKFYIVDRIKELIKVRGAQVAPAELEALLLEHPLLLDAAVIGAKGIGEEEYPRAYVVRREGATITEKDIVEFVSSKVSKVKRLTGGVRFVDSVPKNPSGKILRRELRERAAKEFSQGKKLMGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QZ35</accession>
    <name>A0A3D8QZ35_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Vacuolar membrane PQ loop repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_09764</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-histidine(out) + L-arginine(in) = L-histidine(in) + L-arginine(out)</text>
            <dbReference type="Rhea" id="RHEA:71063"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the laat-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW67015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QZ35"/>
    <dbReference type="OrthoDB" id="8048523at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098852">
        <property type="term" value="C:lytic vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015174">
        <property type="term" value="F:basic amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034486">
        <property type="term" value="P:vacuolar transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000009">
        <property type="entry name" value="PQ loop repeat family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1280.290:FF:000012">
        <property type="entry name" value="Vacuolar membrane PQ loop repeat protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051415">
        <property type="entry name" value="LAAT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201:SF44">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16201">
        <property type="entry name" value="SEVEN TRANSMEMBRANE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="282"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="113"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="114"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00050768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW67015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="316" mass="34885" checksum="13A166A7D674F716" modified="2019-01-16" version="1">MASTLALLPFFLSQDLTTKEALSGIFGSISLATWVCLLIPQLIENYQNDSADGISLVFLFVWLLGDLTNLAGALWAGLVPTVIALAIYFCIADFVLISQCLYYNNKNARKSRRQQSVVSTSSEQEPLLSRRRSSDNTGLPGSHRRTSALSTRSVDGSLVKIEEEQTSTARTWFNNTISILGVIALGVIGWGIAYQTKVWTPTPEHGDMPQTTEVAFGAEVLGYFSAICYLGARIPQILKNHKDRSVEGLAPLFFMLSMMGNTTYGAQILFHSQDREYLLTNLPWLIGSIGTIFEDCIIFVQFHVYNSSKDSDSAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QZK3</accession>
    <name>A0A3D8QZK3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DUF1446-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_09753</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW67004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QZK3"/>
    <dbReference type="OrthoDB" id="10265871at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056362">
        <property type="entry name" value="AtuA-like_ferredoxin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010839">
        <property type="entry name" value="AtuA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47585:SF1">
        <property type="entry name" value="DUF1446 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07287">
        <property type="entry name" value="AtuA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23544">
        <property type="entry name" value="AtuA_ferredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyclic terpene utilisation N-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="Acyclic terpene utilisation N-terminal" evidence="1">
        <location>
            <begin position="224"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="AtuA-like ferredoxin-fold" evidence="2">
        <location>
            <begin position="426"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW67004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="539" mass="58901" checksum="F9B5E03089CBFACD" modified="2019-01-16" version="1">MAENATAFRQGNHPGYEETAWKGLEMSLDVLAERGIKVVINGGSLNPTGLARQVRDLAAQKNLPLKVAYVSGDDLMSVLGPDLASLKDKIPPHLDSVNTDIKIHSPVLSFKSWSSVPLVSANAYLGARAIVQGLRHGADIIICGRVADASPVIGAAWYWHGWTDTDYDRLAGSLIAGHLIECSAYVTGGNFAGFTEYAPQMFVEPGFPRLDMTGKYSSFATQNSTDETRVRVSGIRGAPPPPTTKVAIFYQGGFQSQILVNSTGYGTAQKYALLETQLRKKLKESKVDQMIDLLEFQIVGIPEANPRSQLASTTYCRIFAEAKTAESLMGLLVSFSEISLQHFSGFHAALDMRTAIPKPFLAMYPALYPQDALHESVTFLDGTGTPQLQTIDAGHPPVYERLEQRENYDTASPTPLETFGPTKRLRLGSVALARSGDKGSNLNVGFFVQTPKAFAWLRTFLSSARLKQLMGEDWLEEEYFLERVEFPGILAVHFVVYGILGRGVSSSSRLDALGKAFADFVRDRVVDVPVCLVKGQVKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R380</accession>
    <name>A0A3D8R380_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dolichol kinase</fullName>
            <ecNumber evidence="3">2.7.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_09067</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polyprenol kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.108" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R380"/>
    <dbReference type="OrthoDB" id="377083at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004168">
        <property type="term" value="F:dolichol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043048">
        <property type="term" value="P:dolichyl monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032974">
        <property type="entry name" value="Polypren_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205:SF15">
        <property type="entry name" value="DOLICHOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="555"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="648"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="701"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="746"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="786"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="826"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="46"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="496"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="517"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW68410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="899" mass="99040" checksum="B03F386DA963DB57" modified="2019-01-16" version="1">MPEHIKPSITPQSHAQTLREDAAGLLTRTPHPYHRQYFELPYASDRLSSSAPAQSPLRSTQSTDDEAQDSVRSWSDRYRGSGNSDSGTEADDEHFLKGLPAPKPRPHKGLRVADGLSGTPSPVLSPAILEEYKLQGSRRSGTLQLSEAELRQAVERLRMKRKTEVVRRLMETALLVFVGGIFCLNSRIRDLLWMWRKELACQTLIIFSLIGIYPLRLLRYLSSRRPWKRRIPLEIPPVFDPAPLLYPLAVPMLVSLVLSVEKPTWLLPGIILSISSLPKQLIPAVGELDGANTLHWFLSCIPCLISRDISLSGSIISHPKDIHGWDPEILVLLFPLHQALCTTLGYLTTTSLLSAELQLLSVALIDLLLLSNSPQAVILKALLWGGGVGVLVTCENVLRWGVALARVPKWRFRRSGKHGSALESARSLASSSNALGRLSKSVFSWNNDESSDAEEPVAYRSSTNLKVNTKISGIARPTSLNGSASAVDRQSVKLSAMSDPKGDHSMQRRHTLPILSSLPTKSSQRTPSGRRKRSASSSVQAFFYLTQKQATFRKWLYAGYVYFCVLAIILFGIREYVGRYALADNEPVGWALGYLFGDLPKFRMEVVSANLQRWICLPERNLEGTGACHLGWVEHLRHTSFGTANTRLILFGYWFAVIVVGLAVVFRLSVIYEVDTRRKVFHFMMVAMLLPATFVDPTFAALALSLVLAVFLLLDLFRASQLPPLSKSLAYFLTPYVDGRDLKGPVVISHIFLLIGCAIPLWLSLGSLPRTGNGALAGWEVPTREVSMVSGVICVGLGDAAASLIGRRFGRRKWLWGGGKSIEGSVAFATAVGLALLLAKAWLRIGAWPANNHDDWFTTLWKAGVAAMVASLTEAVLTGGNDNVVVPVVLWLCVKGLDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R3Z9</accession>
    <name>A0A3D8R3Z9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_09308</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Mycotoxin biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R3Z9"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF4">
        <property type="entry name" value="CYCLOCHLOROTINE BIOSYNTHESIS PROTEIN O"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="10"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW68651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="293" mass="33342" checksum="FA0BDF566981518E" modified="2019-01-16" version="1">MSSFSPVFKLRPDRWADEDPADKASTESGEHLLPKDESETTALQVPQRLMTVRHVFIAVFLLILWGGAAFMVGNITGRRQQNDPWGSFENGFVEEQVVTPSDMFELVQRTFTGGVDFTPEGVEVLAPSLYVGEPSPEIDEAWNAIIGGESHYFSVSDVEAIKLWGSDSDRYRDRIRGGWTGTLDLFHCLHCLNQLRKALRRDYYPEEEHRGMIHQLHCIDHLRQVIMCQGTSVISPSEWHDKRGQYINPKQLHTCRNFEKLHEFSKARYNGSIAIARTPKVPLHPHSSILPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7M6</accession>
    <name>A0A3D8R7M6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08348</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW69951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7M6"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF17">
        <property type="entry name" value="ACETYLTRANSFERASE, GNAT FAMILY FAMILY (AFU_ORTHOLOGUE AFUA_8G05690)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13673">
        <property type="entry name" value="Acetyltransf_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="73"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW69951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="222" mass="24979" checksum="1700133A9D10D7C7" modified="2019-01-16" version="1">MSKFKLRPALASDIPSIVSIYMSAFSHAHDLISLQVFPRDQKSSHQFWHDMMTEEIDDPEARILAVTVATPRAEGSELDEEEVVAFAKWNTPRTYPHPSLSPFPTWPHPPAAALANHFFGALSLRKHELVGDGALRPYWYLELVATKPEFQGQGAAGLLMRWGLERADEAGVETYLEASPEGKAVYERFGFKEVGRLVVGEEWFGEQGEFVEVFMVRDGKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R837</accession>
    <name>A0A3D8R837_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_08606</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R837"/>
    <dbReference type="OrthoDB" id="266334at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045120">
        <property type="entry name" value="Suco/Slp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953">
        <property type="entry name" value="MEMBRANE PROTEIN CH1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953:SF0">
        <property type="entry name" value="SUN DOMAIN-CONTAINING OSSIFICATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017682555" description="SUN domain-containing protein" evidence="6">
        <location>
            <begin position="26"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="7">
        <location>
            <begin position="236"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="104"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="170"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="432"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="550"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="799"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="898"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="118"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="175"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="186"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="588"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="603"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="837"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW70209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="981" mass="108087" checksum="9620A8CE05EE57B4" modified="2019-01-16" version="1">MFSVCNRHFAAALLFLCDHLSGTYATTITTAAKATDTADTSKNLPATCEFRTINYITDSLPQQCLKSSWSYANSSTSSSIASSVAEASTIDLSSLPVADTTTVVSATGPNESQGSAKDISISSDPTISIQTPGSTASADVQKSEDDAAKDGDGELNDASFLSFEEWKKQTLEKAGQQNPNIGNRKTSAEGRKRESESMQNNLDSFGDDGEIDLDFGAFRAKEEAPKPQQEPVSDDRKDMEIQSKSARRKDQYRSKDAGKTCKERFSYASFDAGATVLKTHSGAKNSKAVLIENKDSYMLSECAAENKFLIIELSEDIWIDTLVLANYEFFSSMIRSFRVSVSDRYPVKHWHDLGTMEARNSREIQAFLIQNPMIWARYIRLEFLSHYGNEYYCPLSLVRVHGTRMIENWKQEERAEEEDDDDDDDQISEKIQDQEVANGSSKLNEKIEGADAPIGNLSTIEESIAPQTGEPAPNATLVVNFSHSPEQSPTAETVMTTPWEGQGMNLSLLGLLGQEMCLPQDNLGNVGPPLSNSTLISSNSASRTIEPVDASPALDNTMTGAPPKPPVQESQTAVNEAVKSAKTDAAPAADTSSFSVASASSATKTENANTHSKQKGTSTSGASTSLPTIQESFFKAVSRRLQLLETNSTLSLKYIEEQSKILREAFNKVEKRQLQKTSAFLDNLNSTVLAELRGFRQQYDEIWQSTIISLESQKEESRREILAISARLNILADEVVFQKRMSIVQACLLLLCLGLVIFSRVSASGNLDFSGIQSRSRMFLRSPVDSPINSPEFNRVQSLRGESGWNPQHRRQRSDDSVDSRSPSGDESLPTPVSRYSRSEYEHDDHPGNYDGEGTSASEYKRIVATEERKHRNQWVEESSSPEEFSRPVIMRRERSSMLSVVATPPPDAYQDKYPTSSKEAGSYTPGEKGTSGALRSEFPWAGGEYHEHPVDLSPSLPSPPLEERHMFSIARKPLPALPTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8Q3</accession>
    <name>A0A3D8R8Q3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08727</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8Q3"/>
    <dbReference type="OrthoDB" id="6509975at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963:SF23">
        <property type="entry name" value="3-PHYTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20963">
        <property type="entry name" value="MULTIPLE INOSITOL POLYPHOSPHATE PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW70330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="360" mass="38689" checksum="287601036B16C988" modified="2019-01-16" version="1">MDNSPGKYVPGEPHGLKEAYDLGYMVRTRYSNLYQHGSPFISWAKLYPRVVQTARNFVRGFPRTSCRDLATVITVNGTGSPDTFFDSLSPSDLCPAYGNGGTPATEWNNIYLPPITKRLNALISGNLTLSDTDVSIIPYSCGYEPQITGILSPFCNVVTNTELEQYEYAQSLRYYYGIGPGEDLPSRMMIPFLNKLVNILAGGPGQKCIITTFLNDGQLTELGAASGVWNDEAPLSGTTMTKGRKLTCTSEAGTQAVERRNNNERKLMPFGAPVVARDTDNSTLVAYPSSFVTSGTAPASSATAMSTPSAPSTLSAGNSTCVRILLNDAVYPLPSCHAGPGKSCLLDTYVNLLLGIMPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8T3</accession>
    <name>A0A3D8R8T3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_08822</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8T3"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="455"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="458"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="478"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="494"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="525"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW70425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="610" mass="67806" checksum="E3BB4C08E1187073" modified="2019-01-16" version="1">MSVLSLATGTLLVALTWLVLDVLLPLRRNINVAKASGLKYVVVPWYGYNRLTTLLLSRTVLRFFNALLPAPGPTSWRRLISSNWPWKVHYAPFEVLGSDTFLTVAPGGMILNTADANVINQITSRGGDFPKPTHLYKSVDIYGKNVVSSEGLVWKRHRKLVAPSFSECNNHLVWKETLEQTQEMLKGWDSKSIVRRVGNDTKILSLNVISKAGLGRKMKWPSEVEDGVSKLGEGHRMSFSYSLHYLLTNVFYVMVLPKWILKLAPFSKWRKAYKAYYEWAAYMDEIFAEKEAEVGSSQSTSSTVDIIGQLVKGQEENASQPILSPPELLGNLFVLIFAGHETSASSIHFSLLLLAMHPDIQRTVQDSLAEILSSRLGDPSLWNYEHDLPKMLNSMLGAVLNEELRLIPPTITVPKMVNPASFAQTLVVDEREVQIPGGTMIRLCIPSVHQNPKFWPRSSVSNGDHSNKTSNGKASQEAQREDLASFRPDRWIASPSSPSSPGSTESLYTPPKGSYIPFSDGQRACLGRRFAQVEILACLAVILSQYSVELCPSIAPGEIEGEGETEGRRIAAVDDAWRVLRTDLTLVITVQLKGKGIPLRFVRREKCSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8Z4</accession>
    <name>A0A3D8R8Z4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Caib family protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_08748</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CoA-transferase III family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8Z4"/>
    <dbReference type="OrthoDB" id="5863171at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047369">
        <property type="term" value="F:succinate-hydroxymethylglutarate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1540.10:FF:000005">
        <property type="entry name" value="succinate--hydroxymethylglutarate CoA-transferase isoform X4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10540">
        <property type="entry name" value="Crotonobetainyl-coa:carnitine coa-transferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.10">
        <property type="entry name" value="formyl-coa transferase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050483">
        <property type="entry name" value="CoA-transferase_III_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003673">
        <property type="entry name" value="CoA-Trfase_fam_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044855">
        <property type="entry name" value="CoA-Trfase_III_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023606">
        <property type="entry name" value="CoA-Trfase_III_dom_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48207:SF3">
        <property type="entry name" value="SUCCINATE--HYDROXYMETHYLGLUTARATE COA-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02515">
        <property type="entry name" value="CoA_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89796">
        <property type="entry name" value="CoA-transferase family III (CaiB/BaiF)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW70351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="446" mass="48619" checksum="67D6887D831708F9" modified="2019-01-16" version="1">MATSIHARPLLQASWRALFTNRLRSVPRRAFADAVSEDGTLPLKGYKVLDMTRVLAGPYCTQILGDLGAEVIKIEHPTRGDDTRAWGPPYAPYKPGSGKDGAGESAYFLAVNRNKKSLGLSFQHKSGVEILHKLAAESDILVENYLPGTLKKYGMDFETLHKLNPRLIYASITGYGQTGPYSNRAGYDVMVEAEMGLMHITGSRDGPPVKVGVAVTDLTTGLYTSNSIMAALLVRGRTGRGQHIDVALSDCQVATLSNLASSCLVSGEKDSGRWGTAHPSIVPYRSYKTKDGDILFGGGNDRLFGLICEGLGRPEWKSDPKFVVNTQRVANRQELDSSIESITETETTQHWLGVFEGSGLPYAAVNDIQGTLTHEHVLARDMVMEMDHEHCGPIKMVNTPVKYSESKPSIRTPPPILGQHTDEVLKDLLGMGEDEIKALKIEGAVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R956</accession>
    <name>A0A3D8R956_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_08791</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R956"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="154"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW70394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="346" mass="37838" checksum="C4560C898E71F415" modified="2019-01-16" version="1">MAGIPVVDLRLFASDPDRLSGELFDAASKWGFLILTGHGIPLEEIDEVFNLAQGFFAQPKEIKEEKWMNTAQVGYDHKESVIGTQEGCVFGDVAASNLTTSNLSSWWTHARREKIEAFRARCHVLSSQLLTAFATAMGLPPAYFFPAHDPAKRPGNVLRLMRYPALSTQPDANLPSLGEHTDWGTMTLLFTKTAGLEVKSPDAREFVPVPVVEGALIVNIGDGLALWSDGALKSTLHRVARKASLYDQDRYSMAYFVNANADAPLKFLKRGPEGKFTHDERKLDATFGDYQAARMRLFHEKFDSDVDGSGPVLDPKFVAIVKTLGVAHGHAITYGSTGVEQAGVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDI9</accession>
    <name>A0A3D8RDI9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">Complex I-ESSS</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">NADH-ubiquinone oxidoreductase ESSS subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BP5796_08022</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Complex I is composed of 45 different subunits. Interacts with BCAP31.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the complex I NDUFB11 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDI9"/>
    <dbReference type="OrthoDB" id="2147978at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019329">
        <property type="entry name" value="NADH_UbQ_OxRdtase_ESSS_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40637">
        <property type="entry name" value="ESSS SUBUNIT OF NADH:UBIQUINONE OXIDOREDUCTASE (COMPLEX I) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40637:SF1">
        <property type="entry name" value="ESSS SUBUNIT OF NADH:UBIQUINONE OXIDOREDUCTASE (COMPLEX I) PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10183">
        <property type="entry name" value="ESSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="13 18" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="9" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="7 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 18" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="18">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00031387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00046528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RDW71988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="124" mass="13591" checksum="232FC91233B986A1" modified="2019-01-16" version="1">MTLLRSTQTGLRALAKSQPIRSIPTTSSSTSRALSTTSRLAAADHAHEDHYDPPSGWLFGVKPGEKAEKEGWEGIWVYGFFGSLGLAAVAYAFKPDTSIQTWALEEARRRLEVEGILKEPESKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RE30</accession>
    <name>A0A3D8RE30_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_08175</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RE30"/>
    <dbReference type="OrthoDB" id="346839at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051229">
        <property type="entry name" value="ALYREF_mRNA_export"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025715">
        <property type="entry name" value="FoP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965">
        <property type="entry name" value="RNA AND EXPORT FACTOR BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19965:SF35">
        <property type="entry name" value="RNA ANNEALING PROTEIN YRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01218">
        <property type="entry name" value="FoP_duplication"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="72"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="157"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW72141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="255" mass="26115" checksum="22F52640AE44C589" modified="2019-01-16" version="1">MSGKLGQSLDEILSTQKSAARGKGRLGRGRRAPASRLLNNAVAPSGGVKKTAKPARAAVKGTPTGPAAPIDSKIQVSNLPKDVNEQQVKEYFIKAVGPIKRVEISYGPGGVSRGIATIWFARPEGATKAVSALNGLLVDGKPMKIEVVLDARRAANIPPPKGLSERIAAPKSQPKSAAVTKADTAGSGTRGGKARSRRGGAKGARPAKKTAEELDSEMADYFDNGGAAAGTETAATTNGAAQPVANGDAMDEEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RHS9</accession>
    <name>A0A3D8RHS9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_07039</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. TCR/Tet family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RHS9"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1720.10:FF:000014">
        <property type="entry name" value="MFS drug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF158">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14490)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="77"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="370"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="544"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="74"/>
            <end position="566"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW73597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="588" mass="63240" checksum="EC76D2D03E75DC31" modified="2019-01-16" version="1">MSLDITKASEPALVHTGPSAELPTTILPPSAIPITPLDLEESPKIRTKLRLYIILTALYVAYPTFLVFHVIHLANSILQLALFLSALDTTIISQSIPTICTDLHSASGYVWIGGAYLLAKAAMGPIWAKCSDIWGRKLMLLIAVGLFAAASILVALSTNMPMLIAGRALQGVAGGGLVQLSIITISDLFSVRERSIYLGASGFVWALAGSAGPLIGGAFTQSLSWRWCFWINVPICGITFGFLLLFLDVNNPRTKLGEGLKAIDWYGTISILAITTLLLVGLDFGGTIFPWNSPKVICLIVFGTLIIGFFLFNEHHLAEYPLIPLAMFKSWSNNAVFLVVFSHAMVLIGIEYYMPLYFQSVKQTSPLRSGVLLLPLIVVQSVVEIIAGFLVYRTGHYREFIWAGSLLMAIGTGLFINFGADTSIAMIVGLEIIGALGPALLFQAPLAAIQNSVSQAETAAATASLLFLQSIAMSLSVVVGGVVFQNSMDARQSSLAAAGLSKSVLDALSGSQAAANVAITQSIQNATQRQVVLEAFAWSIRNMFILYTCLAAIAIVASMFIKHEKLNTEHMETKTGIQHLAKVKKDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RI61</accession>
    <name>A0A3D8RI61_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-galactosidase</fullName>
            <ecNumber evidence="2">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_07060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RI61"/>
    <dbReference type="OrthoDB" id="2108802at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004352">
        <property type="entry name" value="GH114_TIM-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35273">
        <property type="entry name" value="ALPHA-1,4 POLYGALACTOSAMINIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G07890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35273:SF2">
        <property type="entry name" value="ALPHA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03537">
        <property type="entry name" value="Glyco_hydro_114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside-hydrolase family GH114 TIM-barrel" evidence="5">
        <location>
            <begin position="243"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW73618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="477" mass="52481" checksum="F431F82CAD652F35" modified="2019-01-16" version="1">MTAPSKNNSAKVRNLTKIKFAAQGSSHSAPSTPHETPYDPPNPQVSEDMDDSYDEPSNVHELASSKAPPQFRHSIFYRPKKADKEVVESPPERDSGDYFDMMPTVSEAGSRPETPFDVNLEDPGQGLLNLKPPPPMRDRTGAEALKRKTRAMSVAYIEYAQSAMNSLRKTRNQPDAVVPEQKYQKVTREGKGWFSNWSTRRVILVSASAIIMVLLAVGLTLGLLQRGRGTKKFTNWHPAVGTTWQIQLNSPVTDPSLRAYIYDVDYFDANASTIANLHSLGRRVLCHFSAGTYETWQPDPDHFPPEVIGGSVIGWGIERWLDIRADSVKKIMANRITQAQKMGCDGIVPDNVHVYAIENSGFNITESDGTKYVRYLAGLAHPAGLSIGLANAPEIVNSTIDVMDFGFNEACVANNNCVAYRPFIQAGKPVLHVEYTSGVLADDLTKACTAADTYAFSTLLKDPKLDAWAMDCPLNGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIA2</accession>
    <name>A0A3D8RIA2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_07142</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIA2"/>
    <dbReference type="OrthoDB" id="428854at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="150"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="505"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="154"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="228"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="296"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="347"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="419"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="476"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW73700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="532" mass="56953" checksum="82BC3E4C94B09823" modified="2019-01-16" version="1">MSSSFPSSNPFRRKGSEAPDHNPVTQNKLLTDITNLDRQDVPRIQTKPVKKVRVQSPPPSSPEEDTWSTNRTAPLRRNDLTTATNNDPFGGTISDTSDDESPVRVGQAPPNPFQKTLETMEGGAVPAGVVANPARVSMNVEAFKRLLMTGDSGLGSSTASSTPTAPTLHPGLGDGGSSTDTSSISRQSIFEPVQEPHPESPRTSHEVSEPEEERRRFSTDYTASTATGRKKPPPPSSRHGKLIKMELKDSPTSDVHTSPTQDLEMPKAHFNTSSSSLSSIKSPTDLNKPLPPAPERASHESERESIFDKEAAGKTPEPPSPSLSVKRKTPPAPPISRRHSQLVSDSRLSKLDSGRLSMRMEEDNASIAGFVAGRPRADSAKAPPPPPSRRPGSIRASNSSTSIPVSSVISLPPAVPPTRASSMRQRPPSVSSMETLSSRRASFVPPPPPPHRHGRASFDLPNAPIVSPGSRTSGEYSRRSTDSMRRDSTASSSSYVDRPGTASSGKDILADLSALQREIDALRNASAEKQAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIC5</accession>
    <name>A0A3D8RIC5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Histone H1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_07086</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H1/H5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIC5"/>
    <dbReference type="OrthoDB" id="1110759at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00073">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005819">
        <property type="entry name" value="H1/H5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005818">
        <property type="entry name" value="Histone_H1/H5_H15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00538">
        <property type="entry name" value="Linker_histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00624">
        <property type="entry name" value="HISTONEH5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00526">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51504">
        <property type="entry name" value="H15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="H15" evidence="5">
        <location>
            <begin position="15"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="74"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="102"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="174"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="205"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW73644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="227" mass="23295" checksum="E9F47EC9E54E7BC0" modified="2019-01-16" version="1">MPPKAAAAAKSKTSDAPSYISMITDGITTLKDRQGSSRSALKKYVKANNKITVADNMFDSLFNRALKSGVEKGIFAQPKGPSGGTKLAAKPKAAAAKPAAPKAEKKAPVAKKEKKEAAPKKVAAPKAKKAAPKPKAAPKAKAAKVEKKAPATKKEKKEAAPKKVAAPKAKKAAPKAAPAVVEKPAVLSKTKSGRVTKTKTDAPKAKKAAPKKPATKKATPKKAAASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIF6</accession>
    <name>A0A3D8RIF6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative metacaspase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_07274</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIF6"/>
    <dbReference type="OrthoDB" id="3223806at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006915">
        <property type="term" value="P:apoptotic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029030">
        <property type="entry name" value="Caspase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52129">
        <property type="entry name" value="Caspase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0053">Apoptosis</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="6">
        <location>
            <begin position="130"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="51"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW73832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="468" mass="50668" checksum="21B89F50988A6E07" modified="2019-01-16" version="1">MSGYPGSGYHGGGYGPPPNQYASPQGYYPPQGNYGPPPPGPPGQYGGGYQQPPPPQQYQYSHPPPQQYGGYNGVPNNQPQYNRPGMPSVNSNAYVNGNAAAPPPPPTGAVQFGQGAPQGYAFQYSNCTGRRKALLIGINYFGQRGQLRGCINDVKNMSAYLHENFGYQRDDMVILTDDQQNPMSQPTKQNILRAMHWLVKDARPNDSLFFHYSGHGGQTKDLDGDEDDGYDEVIYPVDFRQVGHIVDDEMHRIMVTPLQAGVRLTAIFDSCHSGTALDLPYVYSTQGVLKEPNLAKEAGQGLLSVISSYSQGDMGGVASNIMGLFKKATTGDDAHNRSIATKTSPADVIMWSGSKDDQTSADATIAAQATGAMSWAFITAMKKNPQQSYVQLLNSIRDELATKYTQKPQLSCSHPLSSSALVTNTWGKWTVFGVIAPGSVATWVQIGLGALVFMMGLKNDEEMDVELC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIK4</accession>
    <name>A0A3D8RIK4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative enzyme activator VAC14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_07319</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAC14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIK4"/>
    <dbReference type="OrthoDB" id="5574975at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010008">
        <property type="term" value="C:endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006661">
        <property type="term" value="P:phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026825">
        <property type="entry name" value="Vac14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021841">
        <property type="entry name" value="VAC14_Fig4p-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023:SF0">
        <property type="entry name" value="PROTEIN VAC14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16023">
        <property type="entry name" value="TAX1 BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12755">
        <property type="entry name" value="Vac14_Fab1_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11916">
        <property type="entry name" value="Vac14_Fig4_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="5">
        <location>
            <begin position="86"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="Vacuolar protein 14 C-terminal Fig4-binding" evidence="7">
        <location>
            <begin position="593"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="281"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="421"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="795"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="889"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="309"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="444"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="454"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="477"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="809"/>
            <end position="828"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW73877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="938" mass="104271" checksum="3D0F2E8E02844A07" modified="2019-01-16" version="1">MDQSIQRALNDKLYDKRKVGALDLERVIREHAAAKDYDKIQKIIQQLCNDYAYAVHQPHARNGGLIGLAAAAIALGPDLARYLDEIVPPVLACFTDQDARVRYYACESMYNIAKVAKGEVLPYFNYIFDALCKLGADSELSVKNGAELLDRLIKDIVSESAATYVSILHTSDERSHDEEDRGSQDGSTDMPTAFSLPRFIPLLKERIYVINPFTRTFLVGWITLLDSIPDLELVAYLPEFLSGLFKFLSDPNRDVHVATQGALERFLSEIKRISRLKKGIEESRKSRSDTKRKRSGSLDSDSMDMAQEVGDDEDSNAEPEEKDVSSDDDWVPGQDVQINFKEILEILTANLDSPLEEDSLLESLRWIVDFLDICPEEVLPFAPKILAHLLPAMASGVDTIRQAAGRVNTSLMNYVVSLSDEGAPSEANSSRPPSRVPTTALKDAGNDKKDGRDSSSTTRGSLSGSRENDPRATEVQTPPPTYNKPSTPMPPQPQVDLDYAAAVNSLTLLFLNDHEATRVAALTWLLMLHRKAPRKVLAFNDGTFPALLKTLSDPAEAVVTRDLQLLSQISRNSEDDYFTSFMVNLLQLFSTDRKLLETRGNLIIRQLCVSLSAERIYRTLADCIEKEEDLEFASIMVQNLNNNLITAPELAELRKRLRNLETKDGQTFFVALFRSWCYNAVATFSLCLLAQAYEQAYNLLQIFAELEMTVNMLIQIDKLVQLLESPVFTYLRLQLLEPEKHPHLYKCLYGLLMLLPQSSAFAALKNRLNSVSAIGFLHIAPRTYVSQSRNNSVTEAVSTFQSHHQRQKSSNTETHASSSSAPSTAGPSNFDRSNRLKGRDEGIRWSELLEKFRSVQEKARRAQRPGGDLDDGLGVVDVRAGEGLDARGFQGMTRMQGPSVPAKDPPAVGASQAAKQSRSSLGKFGRLGGAVSGSRPKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIS5</accession>
    <name>A0A3D8RIS5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine protease</fullName>
            <ecNumber evidence="11">3.4.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_07298</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:67548"/>
            <dbReference type="Rhea" id="RHEA-COMP:17323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67549"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase C54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="11"/>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIS5"/>
    <dbReference type="OrthoDB" id="2960936at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019786">
        <property type="term" value="F:protein-phosphatidylethanolamide deconjugating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005078">
        <property type="entry name" value="Peptidase_C54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046792">
        <property type="entry name" value="Peptidase_C54_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624:SF49">
        <property type="entry name" value="CYSTEINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03416">
        <property type="entry name" value="Peptidase_C54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 11 14" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase C54 catalytic" evidence="13">
        <location>
            <begin position="103"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="58"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW73856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="442" mass="49031" checksum="600F7F7158AB15FA" modified="2019-01-16" version="1">MTNVDFGRYKRIVQYFWDPEPTNDAASQLPVWCLGKQYPPRSSSISLRPIASLNTPPHDDGLVSQLAVEPSQSETPPESTASSVDSGLAYQDGTSEEDGGWPSEFLDDFEARIWLTYRSNFPAIAKSLDPKAPSSMSLSVRLRSQLVDQAGFTSDTGWGCMIRSGQSLLANAFITVRLGRDWRRGTSSSDERKIISLFADDAQAPFSIHKFVEHGASSCGKHPGEWFGPSATARCIQALTNNLASSDLKVYITGDGPDIYEDSFMKIAMPDGAEFRPTLILVGTRLGVDKITSVYWEALKASLQMPQSIGIAGGRPSSSHYFVGVQGTDLFYLDPHQTRNALPLHERVEEYTEEEINSCHTRRLRKISLKDMDPSMLIAFLIRDVSDWKSWRKAVEQAPGKRVIHIADHDPAARNLASERDGAIDEVETFDDEDDEDMVLCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIT6</accession>
    <name>A0A3D8RIT6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Succinyl-CoA:3-ketoacid-coenzyme A transferase</fullName>
            <ecNumber evidence="3">2.8.3.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_07246</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 3-oxo acid + succinyl-CoA = a 3-oxoacyl-CoA + succinate</text>
            <dbReference type="Rhea" id="RHEA:24564"/>
            <dbReference type="ChEBI" id="CHEBI:30031"/>
            <dbReference type="ChEBI" id="CHEBI:35973"/>
            <dbReference type="ChEBI" id="CHEBI:57292"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
            <dbReference type="EC" id="2.8.3.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 3-oxoacid CoA-transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.3.5" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIT6"/>
    <dbReference type="OrthoDB" id="1933379at2759"/>
    <dbReference type="UniPathway" id="UPA00929">
        <property type="reaction ID" value="UER00894"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008260">
        <property type="term" value="F:succinyl-CoA:3-oxo-acid CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046952">
        <property type="term" value="P:ketone body catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.10:FF:000001">
        <property type="entry name" value="Succinyl-coa:3-ketoacid-coenzyme a transferase subunit b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012792">
        <property type="entry name" value="3-oxoacid_CoA-transf_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012791">
        <property type="entry name" value="3-oxoacid_CoA-transf_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014388">
        <property type="entry name" value="3-oxoacid_CoA-transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004165">
        <property type="entry name" value="CoA_trans_fam_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004164">
        <property type="entry name" value="CoA_transf_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02429">
        <property type="entry name" value="pcaI_scoA_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02428">
        <property type="entry name" value="pcaJ_scoB_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707">
        <property type="entry name" value="KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13707:SF23">
        <property type="entry name" value="SUCCINYL-COA:3-KETOACID-COENZYME A TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01144">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000858">
        <property type="entry name" value="SCOT-t"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00882">
        <property type="entry name" value="CoA_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01274">
        <property type="entry name" value="COA_TRANSF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="5-glutamyl coenzyme A thioester intermediate" evidence="4">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000858-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW73804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="519" mass="55580" checksum="4979C64C48D1DEDC" modified="2019-01-16" version="1">MPSSALCFRTARAYTRNSTKQSLLLARTFASTTRRHEINKVFPSAAEAIKDIKPGSTLLCGGFGLCGVPDTLINEVLNQKQIKGLTAVSNNAGTDNSGLGRLLQSKQISKMIASYIGENKTLESMYLTGEIELELTPQGTLAERCASGGKGIPAFYTPAAFGTVVQTGELPLRNKPDGTPDQYSYPKDVKVFDGKQYLMEESIKGDYAFVKAYKADRLGNVQFRLAANNFNGAMGRNAKTTIVEAEHIVEPGEIPPEAVHLPGIYVKRVIQSTTEKAIEKLTVAQDPNEPSAKKALGSGETAAKRERIVRRAAKEFKNGMYANLGIGMPMLAPSFVGPEVEVQLQSENGILGLGPYPQKGSEDPDLINAGKETVTLKPGAATFGSEESFGMIRSGRIDLTILGAMQVSGSGDLANWMLPGKVKGFGGAMDLVSNPSQTKVVVTMEHTDKKGNAKIVKQCAFPLTGKACVSMIITELGVFEVDFATGLTLTEIADGVTVEEIKSKTEAPFKVADDLKPML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJ18</accession>
    <name>A0A3D8RJ18_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_07477</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in splicing regulation. Facilitates post-transcriptional gene silencing (PTGS) by limiting the degradation of transgene aberrant RNAs by the RNA quality control (RQC) machinery, thus favoring their entry into cytoplasmic siRNA bodies where they can trigger PTGS. Does not participate in the production of small RNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJ18"/>
    <dbReference type="OrthoDB" id="9626941at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097525">
        <property type="term" value="C:spliceosomal snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01724">
        <property type="entry name" value="Sm_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000008">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013945">
        <property type="entry name" value="Pkr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034102">
        <property type="entry name" value="Sm_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08636">
        <property type="entry name" value="Pkr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="48"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Sm" evidence="9">
        <location>
            <begin position="179"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="80"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="259"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="282"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW74035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="309" mass="33005" checksum="D1D405B2E6312D35" modified="2019-01-16" version="1">MAAFITNLWESVFTPGPTPTLVVATNVSFACLQLVLLALLIATYSIHFVVLSFLSASLWAAINWFVKELAMAQARADEEAKKRGEATSSGEDSETEAETVIQSASGSGSKEVEVVRKTGELKAPATPKFPARNWDRASSSFRILCAPRVSTSIAIHPPDTLLPATGATSYPTERISIMKLVRFLMKCANETVTIELKNGTIIHGTITSVSPQMNTALRTVKMTQRGRDPISLDTINLRGSTIRYYILPDSLPLDTLLIDDAPKPKNKARKEAAGGTDRGGRGGRGGRGGRGRGGGGFRGGRGRGGGRGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJD3</accession>
    <name>A0A3D8RJD3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_07594</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJD3"/>
    <dbReference type="OrthoDB" id="4898680at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="15"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="649"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="655"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW74152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="714" mass="79770" checksum="DBAE68874B855FC7" modified="2019-01-16" version="1">MPSEARKRRNGQLQACESCRKAKVRCDHGDPICGRCVRRNLSCTYHPAPLTRPRGAKVIPSPPSSIPTATRSPTISFVSPVTPASETPTRTKSLFHKPPSAYGATRFSAIFSENQASFEPALLDVTEDEGSSTVPKVIKTGDRSAALMELAIDTLLNFPTLRVTEILTAGSPYVIDSWVSPTMIQNCLSQIWTQYGALLGGRRSRNSVAQMAIDIMRNTKSSIRTDNEDSDWQNWFGGPRLRWEMIGVVFTWAGFVIKHSQEWDPLFKLEEMKGMNRKSAAEVMNQCASNCLDLCDTDDAEVNDILVVLMKNRWKLQSIIVSDECDRLRIGTGMVVGAFITAGLHRLPHFTKITANSQYRTCLAASLYYLDKCESLFTGRPPLFSRDFCHCPLPLDLSEDDIFNGPDNLARAVAKLDANGWNTDGKIHPTTWLRALCLQLPIREGIVYFSLGVNVQFTKVDIDNLTTQLNDIVDSYPAHLQFATRSQNLSKTRDPCSSSAREFYIKSRLQLDVLQCHFLLQRLSVSRGFVSGQKLLDIAVQMMNVVLSLWLNRDELIHFSFAFDWVVVCYGIPCAGVLCVELLKTAKAHSASERPPLSFSKSDVIQSLTIFIAYLNWIRPSDGNAELCWRLKKVVKRIVDSVLDGTAESAAMPENVPPPPPSPPPPKEANEETTEVDFLSDLDPQLLGLDDLDWLNTIDWTQGDWLDMNQQSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RNF9</accession>
    <name>A0A3D8RNF9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c oxidase subunit 12, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cytochrome c oxidase polypeptide VIb</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_06404</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Energy metabolism; oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cytochrome c oxidase subunit 6B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RNF9"/>
    <dbReference type="OrthoDB" id="1107506at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045277">
        <property type="term" value="C:respiratory chain complex IV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006123">
        <property type="term" value="P:mitochondrial electron transport, cytochrome c to oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00926">
        <property type="entry name" value="Cyt_c_Oxidase_VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.140:FF:000001">
        <property type="entry name" value="Cytochrome c oxidase subunit 6B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.140">
        <property type="entry name" value="Cytochrome c oxidase, subunit VIb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048280">
        <property type="entry name" value="COX6B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036549">
        <property type="entry name" value="CX6/COA6-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003213">
        <property type="entry name" value="Cyt_c_oxidase_su6B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11387">
        <property type="entry name" value="CYTOCHROME C OXIDASE SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02297">
        <property type="entry name" value="COX6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47694">
        <property type="entry name" value="Cytochrome c oxidase subunit h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00074891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00082359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW75583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="98" mass="11624" checksum="AD1C47C9B711D199" modified="2019-01-16" version="1">MSDEERETKPFKFVTGKPRTHATASGQVRFDARFPNQNQTKHCWQNYVDYHKCILAKGEDFAPCRQFFLAYKSLCPSAWCERWDDQREKGTFPTRLDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RQ13</accession>
    <name>A0A3D8RQ13_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Dihydroflavonal-4-reductase-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_06974</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RQ13"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF579">
        <property type="entry name" value="3-BETA HYDROXYSTEROID DEHYDROGENASE_ISOMERASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_3G02250)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="3">
        <location>
            <begin position="4"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW76153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="335" mass="37245" checksum="A18A9A33F398E322" modified="2019-01-16" version="1">MASSCVLVTGATGFIGAHVVDNLLNRGIKVRAAARSRSKAEIMIETRPFAKSILEFVYINDIAEPNVFDQAMQGVDAVIHLASPLNYSVADKERELIIPAINGVRSILQAAAKNNIKRFVMTSSFGAVLDMDREKNTPWTYTAEDWNPISYAEAADPSASPQDAYRGSKKFAEQEAWKFMAQEKPAFELVTLCPSMVFGPTAHPVKSVDTLNESNALLWRVASGVEPLPPARFNFWIDVRDLAEVHVQALLNPNAGGKRYLPVSSQKFSYQLVSEIMRDNFPAEKDRISSGVQEINENVHVDTAPVTKDLNIEYRDFKDTIVDFLTQAYLLEMAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVL5</accession>
    <name>A0A3D8RVL5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Inosine/uridine-preferring nucleoside hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_05887</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVL5"/>
    <dbReference type="OrthoDB" id="432381at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008477">
        <property type="term" value="F:purine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02651">
        <property type="entry name" value="nuc_hydro_IU_UC_XIUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304:SF4">
        <property type="entry name" value="URIDINE NUCLEOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="4">
        <location>
            <begin position="10"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW78035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="374" mass="39951" checksum="63DB9B744B5D63B9" modified="2019-01-16" version="1">MGSTVQKLNVWLDCDPGHDDAFAILLTAHHPHINLLGISTTHGNSSVAHTTINAGSLLTAMGRPSVPVYQGASKGLVRPAVHAPAIHGESGIEGTLLLPVPAVAPKTDKSYVDAMAIALLATPPGTAWLVATGSLTNIAQVFIKYPDLAAHIKGLSIMGGAIGNEFTNAPLGKVDDRTRIGNWSYWAEFNILVDPEAAAFVFENEILNKKTALIPLDVTHLVLADKDVQSSLLHGKAGGSGKGLSTLRIMLVELLTFFANTYSEVFGITKGPPLHDPLAVAVIFNGIADAEIPFYDFEEGKQRRERFEVKVVTEGTHEEAQAGLAKAGQTVVRLLPEGEEGVLIPRGLDVKRFWRVVEDCLEIADEVNKANGVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWU9</accession>
    <name>A0A3D8RWU9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_06133</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWU9"/>
    <dbReference type="OrthoDB" id="438641at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="384"/>
            <end position="696"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW78281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="749" mass="83910" checksum="BD96A732749BE5DD" modified="2019-01-16" version="1">MTDSIIIETQPVEHDIAPSPASANLVIVAPAKNGHGSTKRIAHVLSALYDDAQENLDDEPNFTIWSKETNLDRLQDTTMKLDPCRLSTTSDGKDDSSLILCSGSIQNSMKSCDGVEELAVDQAENIVISASETEVNSSTIETDMSQADKNIRQEWLGTTPFAIEDRIDIQRAGHLDDLIYYQQTIYDNIRETPYDPAHWIDLCQCCLTLGFADIAAAAAHKGLILIKASLGRDYGCEGIVYPSNLKILTKTAVSEKLHTHSPAIVEEELKSLLLICYSGLLSSLLACGTFWEGLRAAKEALSIFPMDMDLLETRDMLRDCFYERQNSLKAKAADNFDESLTLMTRVGKIYQMQYPWMDRRLNDRTPALVRELNDNLNSQICEIKPIILRPHRESFDVGPLGIFALRDIEEGESVLVDKCITNTTDLHPKAQTYCDACHSSLLAPYILPTQIVRPECCEDVVFCSQDCCSTATSGYHRVLCGKDWSWIYGRNGRPKSTGLAPDPMWRVRLFLRMVAVYLADIQSTKTKVHPLQHSLFGRMSANYSPPSYPDFPLTRDWYYYENIGAPTRILMTLGINPFTDPHWTPEVIQTIFWKMENNANMSKINLSTTTPPSSNSPQRENSTGEEIVTSINTNYLFLNHSCEPNISWRGPSSTPFVSTDLLEGINSEIIKPGSATIICRARQKIKKGEELKISYIGDPMGTSNNKQWEGGRQERRRWLSKWFEGGCGCSICTKEAEEVKAMAAAKSKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RX85</accession>
    <name>A0A3D8RX85_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 12">Long-chain-alcohol oxidase</fullName>
            <ecNumber evidence="5 12">1.1.3.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BP5796_06273</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Long-chain fatty alcohol oxidase involved in the omega-oxidation pathway of lipid degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>a long-chain primary fatty alcohol + O2 = a long-chain fatty aldehyde + H2O2</text>
            <dbReference type="Rhea" id="RHEA:22756"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17176"/>
            <dbReference type="ChEBI" id="CHEBI:77396"/>
            <dbReference type="EC" id="1.1.3.20"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 12">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.3.20" evidence="5 12"/>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RX85"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046577">
        <property type="term" value="F:long-chain-alcohol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003953">
        <property type="entry name" value="FAD-dep_OxRdtase_2_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012400">
        <property type="entry name" value="Long_Oxdase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46056">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46056:SF12">
        <property type="entry name" value="LONG-CHAIN-ALCOHOL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00890">
        <property type="entry name" value="FAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028937">
        <property type="entry name" value="Lg_Ch_AO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="FAD-dependent oxidoreductase 2 FAD-binding" evidence="15">
        <location>
            <begin position="218"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="14">
        <location>
            <begin position="266"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="16">
        <location>
            <begin position="585"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="13">
        <location>
            <position position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR028937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR028937-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDW78421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="761" mass="83060" checksum="F15B9ED06D87EB5F" modified="2019-01-16" version="1">MEVLAPLLNPLPEGPEEFFNETQWAILMAIMDTVIPDVRRETQATDNFSHATVPDVKYNSAVDHITLNVVNPPGSQSLDEYFSEKPSDNPRFQQLLKRTLVSYTPEDSKKALSFVLSALNTTIGSVLLTGYKIPFHQQPVNVRQSILEGWRASYLPALQLVYKQMTAVARNHWYKTSPLFPKLSGFPAVPEHYKPGSYYEYEFIQVPEGSGPEVIETDVVIVGSGCGGAVCAKTIAEAGYNVLVVEKAYNYKPTQLPMTEEEGGSHLFENGGVCLTDDGSMSIVAGSNWGGGGTVNWSASLQTQNFVRREWSEDRGLSFFGTAEFQTCLDRVCHRMGVSDSHVRQNHGNEVILEGSRKLGYTSKAVPQNTGGDEHYCGHCTLGCGSAQKQGPVVTWLPDAAKAGAKFMEGFQADRVIFDESEGTKKAVGVQGVWTSRNSKGGVDGPASDRKVREVIIKAKRVIISAGTLWSPILLLNSGLKNYQIGRNTYLHPVNMLLGVFKEDVRPWEGGILTSVCSSLEDLDGHGHGVKLEATCGLPAMALTFLNWTNGFDYKVQALKYRHTNAFISIARDRDTGRIYPDPTSGKPRVQYTPSSFDRANALQGVLALAKICYVSGAIEIHPCIEGIKPFIREASEITSNSSTSTSSNVLEEDIDPGITDPRFAAWLATIEAVGNKPPGAGWFCAHQMGSNRMSAQAKDGVVDPKGRVWGTEALYVSDASVFPSASGVNPMITNMAISDWISRGVVRELRNEGRGQEARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S260</accession>
    <name>A0A3D8S260_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_05090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S260"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF3">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="35"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW80392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="337" mass="38252" checksum="B2409D697CDCFD95" modified="2019-01-16" version="1">MTTLQSHIYKVTNGLSIYLDIYLPTTLTTTSKSSLLYFHAGGLVSYNRKRIYPHIVQACVMRGWPLISVDYRLLPQAKGADVWQDYVDAREFVLNELPRSVKEKYNVEWKGEDVARDLVVVGASAGSYIPFMAAAHSKSLGLQPPKAVLSYYGIPTFSHPLFNKSHVFFEPVVELQVAHFLNEDMQLGETEPHAIFDLSCLNDDGSPNPTYERPKTLRVEGEEPFPRGMLYDYFTEKNLYPSLIGPLDEPFRDGSWSKELTRPKFIMIHGDADVDVPIELQQAIADELGPERARLLVVPGVEHNFDEGLYWDDERLVKIREAWGLLDQVVERGEFGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3J7</accession>
    <name>A0A3D8S3J7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">ER membrane protein complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_05342</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the EMC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3J7"/>
    <dbReference type="OrthoDB" id="369569at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009445">
        <property type="entry name" value="TMEM85/Emc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19315">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06417">
        <property type="entry name" value="EMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017207">
        <property type="entry name" value="UCP017207_TM-p85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="92"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="144"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="24"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW80644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="191" mass="20822" checksum="6ED0297F307D381D" modified="2019-01-16" version="1">MSVASIPPPTPPCWVVDLNAPPVSKPKSTAIPDPPGFPVALSGKKQNSSSSKSPATTTTRIAPTTEEMDVLKLKKAWEVALAPVKQLPMTAIMMYMSGNSLQIFSIMMVVMAFKNPVMGLVATNQAFEKFESEGTREKLWQVKGVYVLMQLLALALGVWKVNGMGLLPTTRSDWLAWETARDPLEFAIPAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3L7</accession>
    <name>A0A3D8S3L7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_05554</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.366.10:FF:000002">
        <property type="entry name" value="Probable polyketide synthase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF37">
        <property type="entry name" value="SI:DKEY-61P9.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="6">
        <location>
            <begin position="4"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="7">
        <location>
            <begin position="913"/>
            <end position="1192"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="5">
        <location>
            <begin position="913"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="5">
        <location>
            <begin position="1063"/>
            <end position="1192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW80856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2184" mass="240153" checksum="96D54153773A4287" modified="2019-01-16" version="1">MTEHGDIAIIGMACRVAGANSPSELWDLLESSRDVQTDITRFNINTFYHPDGGPRKGLTNVKHAYMLDNNIIDRFDHAFFQVTPVEASAIDPQQRMLLEIAYEVIESAGIPLDDFMGTNTAVFAGMDSCDYHNIMTRDIEATPRYLATGTATCMAANRISYFFNLSGASMAVDTACSSTMTAVHQAVRALQQGDSSMAIVCGAKLILTPDMYIPSSELGFLSPRGRCHSFDASGDGYGRAEGVLSLLLKPLANAIRDNDPIRAIVKGVALNQDGRTQGITLPSSEAQKNNMNKLYGNLSLDPASIQYLEAHGTGTAAGDPLEFSAINEVFSRTDRPENLIVGSVKSNIGHLEACAALAGIIKTVGCLERKRIPSQMHLTTPNPKIDFTKVRIPMATLEWPCTKGPRRAGVNTFGAGGTNGHAVLEGYDRDLQSPSSATNSRRFLYRLSAADEDSLLRLCEIYAEFVGKKNPNIHDLAHTLLSRRSLLRYSASFSAKTADEIIKKLSSKSFEVQMRGQRSITNVVFVFTGQGAQWAGMGINLFAQLPVFANVIKQCDQALANLPDRPDWFIVDEIMKLDTESNVSQAHISQPLCTALQLGLVEVWKSWGLKPNSVVGHSSGEIAAAYAAGFLSLRDAIVIAYYRGTCLAPLVSVSIKSEPKGAMCAVGLSEVDAISLIAKYSRDVDLAAVNSPKSCTLSGDREKIEEIVTSSEENGIFCRKLKINLAYHSHHMLAVAKQYEEALRDASISPLNSSQNCPMFSSVTKEMLRAENCTAEYWKDNMVSTVEFSSALAECMKSAPKDTTILELGPHPALHGPIKEILMDLEKEDIKIFSSCTRGKDDMDLMLKSAGAMIVSRVALDARAINAVVDNTNKPASGNVLTDLPTYTWDHSTPIWHESRISRNIRFRKFPHHELLGSRYLEDIPSSPSWRKMLMLKEEMWLQEYQDTQNERSIPSSIFILMAVEAARQLNHSTKPVQGHIEITDINFEKDLDFDLFRTPETVVELHFGAHMVGDSAYTFNISSFPTDESGTGTRHCFGKLIWSSEELQLPELANINVSHDPILLHRAKGVYPDMAYNMIDLTFGLSSCAGEFAAPLEASELCIDPIALNTILNATKSLALNDRLPCSTKLSYISSLRIPCTPPTSRAGRFVVRSNSQSSPKHTSDIEIFMAEYTMFVSGVELTNMGALKPSSVLGSLYFQERNMPDITIGSLPGTSFEDCVDMVTHRWPMADVGLYHLNASEFEETMKLLHRHTRRAFRSIQAVGYGNGTYDNLRIVDELSPTIKLHLLVADEVPDISKISEVLHIGGILCLKSNTSDPANSRSFARIGGITRFEGSRAECTLWRNLGHANGIQPRKPTKLFASVEDSSQYLEQPVDEMINLEPECVTAFCEAQNQPYDAVIVESKEKSIISTWPGNNFIPWMQHLLKFAERIIWATTKHVGDPFTSLAGILLRTLQAEQPSLKVIWLTFENSESEDVIRDMITSARFGSLMDGNEIHYDMRNSKSYITRYLPDDELSALNGVSIPCRTISSILGKDYDIGMETGQAPSILVSNHDDSTELQANNEILIDVVASVVDEADVKIFSGKATSLPGGFFAGYVLSSSNKSFRSGPPVVGWSTEQGKSNRLTVPSIQSYECNDVNDLPASAAHFAAMCVSLAVVDGHARARMGDTFQLHVSGLLKEAIERYVLDCGASVVESEYANAATFVVAIDVSKGLTVNGNYVDVEKYLVSDHGIYITGRVWKEHPVFESPLSLYHLPDLKHSFQGQYETNYSCVIIHESIEDVEESIAVYKKPRMIFSDGAYIIIGGLGGLGRFVCSWMVENGAGNLFVISRSGLNSDEAQETFDRINATDAIMEVIKADACDQAAISEALSRVRQRFAIKGILNMAVLLGDAPMASMRGSDWDLALQLKIKSSWILHEATLHDELEFFILFSSIASVLGNRNQAGYNVGNSFLNALAKYRRSHGLAGISIGLGAMIDTGILHALRQGPGLLETLTRSGLSHLAKHHLAKIMEAAVTESHNPASTRSFILTGLDMFERVDDRLVGAKDQTMLYWTELPEFGFLQSYKKTWDMDDGHGNEMTLKEKVATLDENQMRETVMNAFLSFLAGLLGFQTQIFDRQSPLVVYGLDSLSAVSCQYWFHRELDAAVKVSEILGAASFLGLVGLVCERIKPTEGSMIVNGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3R6</accession>
    <name>A0A3D8S3R6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_05606</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3R6"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF70">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="147"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="320"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW80908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="508" mass="56783" checksum="B3D943F17B2E80D4" modified="2019-01-16" version="1">MAGDIEAIQMQESRIDDAALKALPADEGYELFEESTVAPVSAEAGKAVLRKLDLHLLPLMCILYGLNYVDKVAMGYAVLFNFRTDLGLHGTQYSWASSMFYFGYLVAQYPANYCLQRYQPQRILSASVIAWGILMIAHLGLKNFAGVMVVRFLLGVAESVVSPGFVLYTSMFYTRREQVLRTMLWGAMQGTFSILASLLSFGLGHITNTALKPWMYIFLVLGIVSILTGLGWLFLMPETPNKAKFLTHEERIIAVQRVAENMMGVKGYEWKSYQIWHAIKDVKTWLLLAFVLFTQLPNGGLSSFGSLVISGFGFNAFKTLLIGLPSSIVSSGSMVVWGYFSMTHGNLRTWGMMIPLLPAIAGIAAVYGTSGTDANKYGRVVAYWLINSYAVTWPFCLTIVGQNVSGHTKRAVTNTMLFIIYAAGNIAGPFFFRAQDAPKYVLAITIILVCFCVSLMCAMTLRWWMIRENKRRDAQYGVVESLQDKRDGMRLGMHDKTDLENPDFRYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S9E2</accession>
    <name>A0A3D8S9E2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uracil permease-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_04460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW82969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S9E2"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW82969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="581" mass="65678" checksum="E7C57E2AA099F7D8" modified="2019-01-16" version="1">METPSTWKEAAVEKWRNFRFALTSKQAFLDWVQVPPYIDEDGKINEWRNEDLSPTPPEKRTWSWFNWVVFYFSSGFGNWTLGSTMVGIGLNWWQAIIAIFLSQMISSTAMYFNGRCGITYHIGYPCVARSVFGMWGSYYYVAARAALALIWYGVQLYSCAALMDNMFRAIFGHSYTQIPNHIPLSEGITSRRMMCFFLAWLAHLSLARLRPNQLTKFFWAKLIVLVPAMIGLFIFCIANTNGNVGPLYSPVAGDKLGWLVMFGINSGMGNSATYITNQPDMVRWSKKKNGAQWSQLIVNPITVTVSSTLGILATASINNKWGLDLWNQWDLLSAIMDRYWSPGPRFAIALCAFCWTFYFMGINIGGNMLPFGSDCTMLFPRYLTIPRGNYLVTFAAFAIVPWKIEASAAIFTKFLSGYGLFMASVASIMICEYFFLTKGNVFISHLYDGSKANKHYYYHKGWNVQATIAYVIGISLPFPGFVGTLGPKVAATATHIFEFGWLLSFWTSFIMYYLICSVWPTRNQRLIKEMGLGWEQMAEELDVIDGTVISGESSSENGVELVKEGVVIQEKSGDQISKEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S9M9</accession>
    <name>A0A3D8S9M9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyltransferase family 8 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_04451</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW82960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S9M9"/>
    <dbReference type="OrthoDB" id="3527108at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017755269" description="Glycosyltransferase family 8 protein" evidence="2">
        <location>
            <begin position="24"/>
            <end position="684"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="249"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="334"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="565"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW82960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="684" mass="74940" checksum="F4A2B5636888A0C8" modified="2019-01-16" version="1">MARSTKLMVFVAIALILMFYALQSSVPSKTNLATPPIPAAAPRPQQTKQSEHSIAPPAPAAYRPPQPIYKPIPPSKALPPVLDNFPLAANAASPADLPPVPAWNVPPRKHVPEVTPLFIGFTRNWRLLQQTVVSYITAGWPPADIIVVENTGAMDSNRRGRLSMQNPFFLNHTRLQLLGVNVVVTPTLLTFAQLQNFFLFTAIEKDWPQYFWSHMDVLVLAHESLVLDGPAPKAGVEEDMAPAVPAGEALPEEKPATPGEPVPTPLPPPPPPPPPPPPMKEPAAETPAKGKPVPLHPEKPIPPPLEGPSVAEALAEKPVPPPLKGPSVAEALAEKPVPVPPGTPVPSSPSKGPPAAEKPVPMPPGKPDPLPLKGPAAAEAKVKARAEPAALPPPKYENAPRQPQIHSPRAPKLISLYRHAVDVLRDTNRDDWAPAPGREWDNSHGPPEHWAHKIYQPHPEKQLTNKRWAARFFHYDNLALVQTKAYEEVGGWDTSIPYYMADCDMYERLLMRGFKITDANAGRFFDVGTSLDDLSVLYRKRSADGTMKNASFLDVNAIIDSDEPEKFIIPDPPSPSSHHSSGRPDQWIDDAPNSPAFQNILDISEQMQASKLNSKSGRNLWKSRQKGGEGEPFYISPQDFEAGVNTATEYGRHVFGEKWGHRDCDLLNAGLSEKDAWKVKHDWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SA31</accession>
    <name>A0A3D8SA31_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Zn-dependent oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_04472</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW82981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SA31"/>
    <dbReference type="OrthoDB" id="203908at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051603">
        <property type="entry name" value="Zinc-ADH_QOR/CCCR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44154">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44154:SF1">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="2">
        <location>
            <begin position="30"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW82981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="303" mass="32583" checksum="11083B653D61939F" modified="2019-01-16" version="1">MSFDERTAVHSAANYTWHKPANQDQMLQTGDASTTGASCLPAPVDSELSKLHNPASMQFPEGAIVATAMGGMGRAFDGGYAEYTCVSARNVQEIKTALDWEVLGAMPEMMQTAYGSLYEVLKMQKGDRLLIRGGTTSVGLAAAGIAKMHGVYVASTSRRADREQMLKAAGAEEVLMDDGKLAMQLKGKEKFDKVLELVGTTTLVDSLQCTKAGGICCMAGTVGNSWTLNEFQPFESIPYAVSLTIYGGGPEQFMATPLEEMAQQIKDGTMKIQIGKVFKLDDIVEAHRCMEENRAGGKIVVLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SBC3</accession>
    <name>A0A3D8SBC3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Amino acid transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_04962</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SBC3"/>
    <dbReference type="OrthoDB" id="3257095at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF4">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="100"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="229"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="348"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="408"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="479"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="509"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW83471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="60343" checksum="DB8E32CD971D73EB" modified="2019-01-16" version="1">MSNVTGSRAHEPELRSEKLESQGIPTAMPTKSLDGVHITENAHGVESSTGYDQQDMYRMGKIQELYRSYPPLSTLSFAVVLTAVWEYLMMANTQGLIDGGLAGVFWSYIWTFFGFGFVILSLAEMASMAPTAGGQYHWVSEFAPPRFQRFLSYVTGWMSVCSWQAGNASGSYLTGTIVQALLAINDSSYQPTNFQYQWQGTLFMFAMVLVLFLFNVYGARIWPKLQNPLMVLHCIGFLVVIVVLWAMAPHQSAKAVFTGFSNTGGWSSLGLSLMVGQITGIYSLVGSDATAHMAEEVRDAGRYVPISIFWSYVGNGILAIIFLVTYLFSINDLDAALNDPSGYPFIYVFQTAMPTSGVNALTILVLILVIAANISFNASTARQTFAFARDKGLPFSDWISRVDKDKEVPVNAIIFTCVITILLSLINIGSSVAFNAIISLQIVALMMTYCCSISCVLYRRIVHPELLPYARWSLGKWGVLVNSIGVAYVTFSFFWSFWPNTTPVDVGSFNWSVVLFVAVFALCIVQYVLRGRKVYFGPVTTVRHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SH19</accession>
    <name>A0A3D8SH19_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Epoxide hydrolase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_03769</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SH19"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017561378" description="Epoxide hydrolase N-terminal domain-containing protein" evidence="5">
        <location>
            <begin position="22"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="6">
        <location>
            <begin position="32"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="339"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW85444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="416" mass="46447" checksum="D7C004E0D0024220" modified="2019-01-16" version="1">MFLPFPQYLAFALLSIHGTVCTELGTNPFNLRPFSINLSSGVRTMLNKIKTTELPHFPEYPDVGSSFGIDLNTLRSLRKEWLTSFNWGKEQNSMNQFKHFEATIEDLTIHFIHEKSTDADAIPLLLLHGWPGSFLEFLPVIDQLVQTGATSLGKPVSFNVIVPSLPGFVFSSPPPANWTVHDTARVFNTLMTDVLGYSTFAVHGTDFGVGPGYALYDEFNETTRAAHFVFLPFYPLKPDALQALNISLSPLEKFEEQGFEQWDSSGSGYFLEQSTKPNTLGLALYDTPVGQLAWIGEKFISWSDPHAGSGGSVLDSNEILRSVSLYYLTRSFISSLYIYAQNPHAFATQYTKAHTNAPMLFSAFKYNVAFWPPALVEKVGNLVLYRNHESGGHFPGLENPSALIEDLREIGTYWTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHH5</accession>
    <name>A0A3D8SHH5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2 type master regulator of conidiophore development brlA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_04047</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHH5"/>
    <dbReference type="OrthoDB" id="6910977at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:002724">
        <property type="entry name" value="Similar to transcription factor Zn, C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003">
        <property type="entry name" value="TRANSCRIPTIONAL REPRESSOR PROTEIN YY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14003:SF19">
        <property type="entry name" value="YY2 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="277"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="309"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="340"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="223"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="385"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="223"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="408"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW85722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="457" mass="50528" checksum="02359A4C8867B37F" modified="2019-01-16" version="1">MELTPHSTHSPNSPYHYPSDSQPVYEYPSPAQSDSRHNSTESLQGLALYSCQMSSSSSTADGSSVPHLASSAPTNWPTVALQHRGTTPNLSTRLPHPTEYSAYGPVPVSSSYSHDIYAASTAEVSVISTSPLPSSNVSQRSSFSSAPASEIYTQAGSISSHTPRIKMEDYNDYVAANESMPYGSPQAPFNLLPSSNTFPGHLEANYYPEQSSLNWPKVEYTNPTELQPYSSQGGYGGTRSGSENPSASDGGQPRRASSMLARTRQPRKLTTKEDANFQCQVKGCGKLFGRSYNYKAHMETHDASREYPFPCTVKDCNKKFVRKTDLQRHHQSVHMKQRNHRCDYCSRYFARKDTLRRHMEDGCSKRFDIETVDFRPRAYSNGEAIPMKTSFRPGEGESHARISPYGSRYTSPPASNTHNGSYEAPLTSAPPGQYYVASSRSHYAQADASSQDPIWNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SJF5</accession>
    <name>A0A3D8SJF5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Purple acid phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_04233</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SJF5"/>
    <dbReference type="OrthoDB" id="45007at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00839">
        <property type="entry name" value="MPP_PAPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.380">
        <property type="entry name" value="Purple acid phosphatase-like, N-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041792">
        <property type="entry name" value="MPP_PAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039331">
        <property type="entry name" value="PAPs-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025733">
        <property type="entry name" value="PAPs_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015914">
        <property type="entry name" value="PAPs_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008963">
        <property type="entry name" value="Purple_acid_Pase-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953">
        <property type="entry name" value="ACID PHOSPHATASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22953:SF153">
        <property type="entry name" value="PURPLE ACID PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14008">
        <property type="entry name" value="Metallophos_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16656">
        <property type="entry name" value="Pur_ac_phosph_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49363">
        <property type="entry name" value="Purple acid phosphatase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017494749" description="Purple acid phosphatase" evidence="4">
        <location>
            <begin position="21"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase N-terminal" evidence="7">
        <location>
            <begin position="34"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="178"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="Purple acid phosphatase C-terminal" evidence="6">
        <location>
            <begin position="425"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW85908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="500" mass="54276" checksum="6F8FED33B40E0053" modified="2019-01-16" version="1">MVNSVTLLKWLPVVATGVMAGASYPTIPTDLTTPVQQRIAINGPDAISVGWNTYEKLNQSCVQYGTSSDALTEEVCSTTSATYATSRTYSNAVTLSSLTPATTYYYKIVSTNSSVEQFFSPRTAGDKTSFTISAVIDLGVYGADGFTIEADLTKKSIIPTIDPSLNHTTIGRLAATIDDYELVIHPGDFAYADNWFLRPKNLFDEVDAYEAILEQFYDQLAPIAGRKPYMASPGNHEADCEEIDFTTSLCPTGQKNFTDFMNRFGQTMPTAFASTSSNDTAKINANKAKQLANPPFWYSFEYGMIHVVMFDTETDFTDAPDSPGGSAGLNSGPFGATNQQLEFLEADLASVDRTVTPWVIAGGHRPWYSTGGSGNQCSECQTAFEPILYKYGVDLGIFGHVHNSQRFMPTNNSIADPNGMNDPLAPMYIVSGGTGNIEGLTSVGSNVSYNAFAYADDFSYATVTFLDSNNLQVDFIQSSTGTILDTSVLYKSHTEQFVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SJS4</accession>
    <name>A0A3D8SJS4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_04353</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW86028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SJS4"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017799447" description="FAD-binding PCMH-type domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="122"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW86028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="581" mass="61938" checksum="86A0A57D9F42B387" modified="2019-01-16" version="1">MLLQALTKSLAAASLLLSFGDAVPTIGNSSCKSIPGDHAWPTSVEWEQLNQTISGQLIGTIPLASVCHIDSYDNYNATACAALQAVWDLPGTHLPYSGEIDSAWFQNDSCVPFTPTSQPCELGNYVSYSINVTGADDVIAGLQFAEEKNIRLVIKNTGHDFLGKSTGKGGLGLWMHNLKTTEYISNYTSSYYDGAALKIGAGITGAEAYTAAHQYGYRLVGGECPTVGLAGGYTQGGGHSLLNSVYGMGADNALEWEVITAQGQYLVATPTQNADLYWALSGGGGGTYGVVLSLTTRLYQDGEVGGAALFFNATLVSNETYWAGIEAWHTALPPIVDAGIVVIYELVGNTFSSLSITAPGMNATQVAAQFAPFLASLDKLGIPYSFVPRTSATYFDHFSQDFGPLPDGSDPASMIENSRIIPRATLLDPEGNSAVVGAMQTAVASGNFLLGCNALNVGAGGNFTRSDYPDNAVLPYWRDAMVVCLMIGIWDWDVPRSNMEARESELINVITPAFEAASGSGAYLNEASFKTPDWQEQFYGTNYDRLRAIKRSYDPNDLFYAITAVGSDAWVTDSAGRLCRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMA0</accession>
    <name>A0A3D8SMA0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_03005</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SMA0"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209:SF804">
        <property type="entry name" value="FE2OG DIOXYGENASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10209">
        <property type="entry name" value="OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="262"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW87311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="426" mass="47762" checksum="E3D8FDEE5DA8248F" modified="2019-01-16" version="1">MSPTLSTNGMPIFVIGKAAEVAGCAASSGAIHDNDAEMADVLQPAVAHEAKPQESGKDEYVYFHSGSEATYRKVVPKDQATSFTSIPVIDIGEIDNPSLAIRKGIAKEIYDACSNCGFFYIKNHGIPEELIKDTFEVIKRFFNEDLDVKMDAHSQKNPAIRGYEPMFYTKLDPTTTGDFKEAFTMGDCVIEPEQDYIGKVGSKPKASITKPQNIWPTKAPYFRVGVYRYYKSVLPLAMKLVRMFALAFDLEESAFDEYFRFPITGMRPLHYPPMPPDTGASGIGLGAHADFSWLTLVLQDSVPALEVLNQDGMWVDANPQPGTIVCNVGQYLERHSNGKFIATVHRVRNKTGERRYSLPFFLTLDPDVNMGPLKCCVEDGEKPKYDPINVGELYIRRVLPARLKHPTSIKYRDVPEEQWKYEFLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMB4</accession>
    <name>A0A3D8SMB4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03183</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SMB4"/>
    <dbReference type="OrthoDB" id="10260961at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103:SF2">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="142"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW87489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="480" mass="52792" checksum="774BB8F4E672158F" modified="2019-01-16" version="1">MLPPPTIVFTIPSIHDDTVLDCRVYHPLRLNPSTVSQVSAPWEKKAAIVAHPYAPLGGCYDDAVVDIVASTILKQGFIVGTFNFRGAGSSKGATSWSSKPEQGDYISMIGFMRYYMHFLAPPTRRHLSLGHSPFVHVLNDDSEAIRTPPPESDHTSGPSAPAPTTTTSSNSLLILAGYSYGGLITTCLPPLSSPTLLPLFNTPQHGSPHAEIRLRAQNLATQQNEMLQTRFEALVSQSAPISPLRSEHGHISIDDNGKFPKATLGVRMGGEEDLRRSSHESHQPRRSFTIEAPERVRMSLDKVRSLARTNRFPCQRDGSSGSMDASVRSKDGASDTSLRHGSNRPEKADPPSDLLEEIPGITQVDAAYLLISPPKGLVGSLATMWSSWRAAQYAQGHEKEFITNEDLKFVMNPTLTLFCQDDNLISARKLRSWCERMEEAREEGKSGFSFVEVKAGGHFWHDHDALRTLTQEVKAFAGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SN03</accession>
    <name>A0A3D8SN03_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_03384</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SN03"/>
    <dbReference type="OrthoDB" id="2283631at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF79">
        <property type="entry name" value="C6 FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="53"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="687"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="792"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="703"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="726"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="794"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="830"/>
            <end position="848"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW87690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="895" mass="100495" checksum="2BF61DE1640256E2" modified="2019-01-16" version="1">MAGEPGTRRLLPQSSQMQSFAFAPDNFGPRENQKNYVFVDEHNRHKRLKVMRACEGCRRRKIKCDAATTNTWPCSACIRLKLHCVPPTVNYDNQNYGGSPQMYEPGRVGYGGGEDDYHQHLGLQQNLAEAPRHNPSMYQPPTQYTDNVGVYQPVSYAPEPVSNHQPVHYGNLQTPVSVMDQQYTSQNVFPTPPMQQAHQHSSSPESYEQDQYGQQNLADLLGELRMNEAGTAPYLNSKNNKNNLSDEPAAFEDVDEYRTVLPPTLSGPGSKIRIPPELMPDEETVLQYFDMYFANVHPYVPVLNKTSFYQQWHTNRESISPLVLEAIFAISGRLADEPAQGHQWLALASKHADSFMDIPRLSTLQAMLIVLKARESAPKRGYYYRSWMTVVQCVAMAKDLGLDEHYEDHKAGKPCGSNQADCITKTRIWQTIFLTEVMIGSPQGRTDLAVDIETLDLSVQRPAPGNDDTEFHVTRNFTYLAKVVRNVRRMNDVYSKIKKKKEWGIDPALIQLNPSFETWMNDLPSDLQITFSSDGSPPWLPSHYIGNLHSYYYLSIIMLHRPQLQFMEPTDVSGDWKRHMMICYNSAKLLCRLQEGILQSFGLTGLLCMQRGINFTIYCVLTCTVLHLVALTSPDPDLSTDAREYFTRHMRILERCMSSWPMPDMQQQIDALREAFSADTRKPFVLKPSFPYGSPGAPVHSSPPRSNMNRQPTSIAGQHGLEHQSAHQPQVSYTNHPISPPISAGGVDTKSDSPAVQSLVMMASGHGHRIPQQSSVPMAETSAWNPTRIFDQWTTSFGTPPASSTSAPSQAPLKLSVPGAPEVQSLPDVQSLPNVSLPPNSQPLPQQQYSAAPIPSFVSPSMWQESVASVYEGGLKRQWEYDDGNMLNSMSKRSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SNA3</accession>
    <name>A0A3D8SNA3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_03358</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SNA3"/>
    <dbReference type="OrthoDB" id="3554168at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW87664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="180" mass="20506" checksum="2C3DD5D5E3EAEBC5" modified="2019-01-16" version="1">MVTSSNASGNTPNPEDHSIATSNVFHQRQRNITRPPDVFSPFQRYSSSIHDFNALCLYFESGVFDTEQLYRTVKDNLMREFLKFAHDLNDSRIVSDIAQSQRRLPEFCLARLIELRRSGLSTKVAKQSIAAEVREGNWEVGHFLSSILADGDANLSWIDRYMSASLRRAFIFRGLDALSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SNR3</accession>
    <name>A0A3D8SNR3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_03630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SNR3"/>
    <dbReference type="OrthoDB" id="4136194at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030638">
        <property type="term" value="P:polyketide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009959">
        <property type="entry name" value="Cyclase_SnoaL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436:SF1">
        <property type="entry name" value="ESTER CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38436">
        <property type="entry name" value="POLYKETIDE CYCLASE SNOAL-LIKE DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07366">
        <property type="entry name" value="SnoaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW87936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="152" mass="16937" checksum="ECBCC99F77055EAB" modified="2019-01-16" version="1">MAGTVSSMGTSTNTSPAEMKRIVTSFYNDIWNVFSLAPVESLLAPDMTFRGTLQSGDTDREGFKLYVLEVEAAFPDFHQEIKELICDVDGQRCVARMLWSATHTSEFRGVKPTGKKFEYPGFATFKIKDGQITEVLAIGDTWGLWKVILGLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SX80</accession>
    <name>A0A3D8SX80_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_02102</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW90937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SX80"/>
    <dbReference type="OrthoDB" id="37537at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19077">
        <property type="entry name" value="AKR_AKR8A1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050791">
        <property type="entry name" value="Aldo-Keto_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625">
        <property type="entry name" value="AFLATOXIN B1 ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43625:SF78">
        <property type="entry name" value="PYRIDOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="13"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW90937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="332" mass="36401" checksum="32D9BF5C5A0B28EB" modified="2019-01-16" version="1">MAVVTGKAITNNGLGLMKFVLPNDITPDDIIFRVLKTALECGANVWNGADFYGTPDHNSLHLMNRYFTKYPEDADKVVLSIKGGVVSLATYQVDASPEFMRSQVDSANKVLDGKKIIDLFGPARVDPNVPIETTVEGLAQLVKEGKIGGIQLCEVRADTIRRAAKVARIDMIEAEVSLWSTDIFTNGVAETCAELNIPIQAYAPLGSGMLTGQIKSIDDLPATDRRRLHFPRYQPENLKKNLALVRELKKFAQLKGYSIAELALSWVKSGNGKVGKPFVVPIAGARSERRVRENCTGVDLSEGDLEKIATILDAFPVAGERYPPKAMEYSEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXX7</accession>
    <name>A0A3D8SXX7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BP5796_02330</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SXX7"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000016">
        <property type="entry name" value="Solute carrier family 25 member 23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="13 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 15" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="26"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="123"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="14">
        <location>
            <begin position="228"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDW91165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="325" mass="35570" checksum="298F71CC835DF092" modified="2019-01-16" version="1">MSASEGGVLKPKYGQYTLQAREIISQPVMAAFCAGGVAGAVSRTVVSPLERLKILFQIQSVGREEYKLSVGKGLMKMWKDEGWRGFMRGNGTNCIRIVPYSAVQFGSYNFYKKFFAPSPGAELNSGRRLVCGGAAGITSVFFTYPLDIVRTRLSIQSASFAALGGAPKKKLPGMWQTMVTMYKTEGGIFALYRGIIPTVAGVAPYVGLNFMTYELVRQYFTPEGDKNPSALRKLAAGGISGAVAQTCTYPFDVLRRRFQINTMSGMGYQYKSIFDAVKVIVAQEGLRGLYKGIVPNLLKVFPSMSASWLSFETTRDFLTSLKADP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SY31</accession>
    <name>A0A3D8SY31_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminodeoxychorismate lyase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_02407</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SY31"/>
    <dbReference type="OrthoDB" id="5288718at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW91242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="30761" checksum="A41991638B4981CC" modified="2019-01-16" version="1">MAPDFQLFSSLRYDPILLSNSVNTQLSPGKQPSPFYMLEYHRDRILQAAEHFGWSQAIAALEGTEGLTRLASKLGEYSFVKSLTPFRVRVLVAHDGTITAESNSTLAVSLENLYPARIPPPLTAAPAKVSPLTGGALTLGDNDTVAGDARKGEAWTILADSAKTTPNPYTAYKTTSREMYNTARERVGIVDLTLKKEVLLVSDQDEAIMEGSMTSVFFWRNGKWTTPPISSGGQAGTTRRWLLEKGLCVEEVVKIDSLTDGEECWISNGVRGMNWGKVKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYT2</accession>
    <name>A0A3D8SYT2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Methyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_02093</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW90928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYT2"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF50">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW90928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="304" mass="33884" checksum="DFF3804E74C35D17" modified="2019-01-16" version="1">MHGEAVYNTLRKNKTLPDLSPEGGSTNKLMDTVIGETTRNGLNNQHQVLIHVIDDKILHAPINPSSITRVADIGTGTGVWLKGISAYLDATPTEDGQTREYIGFDISASHFPPTHPSNFHYEIQDISKPFPEALRGKYDLVHVRLLVAALPEGSMKTAVENLTSLLRPGGWVQWDELDSETWGGRVPSSHVKQMYEVVQKYLVQKNMERHIQTAFYEAAKLNPELQNVSVEAFNTLKRGPDFRDRLNSACLWSYAKAAKLVMQGTGVADAEDKAEKLRAGAVSDLENDGTYWDSDLWVLLAQRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZ55</accession>
    <name>A0A3D8SZ55_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Carbon-nitrogen hydrolase-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_02772</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZ55"/>
    <dbReference type="OrthoDB" id="10250282at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07564">
        <property type="entry name" value="nitrilases_CHs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.110.10:FF:000016">
        <property type="entry name" value="Nitrilase blr3397"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044149">
        <property type="entry name" value="Nitrilases_CHs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044:SF12">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46044">
        <property type="entry name" value="NITRILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="256"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="256"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW91607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="380" mass="41457" checksum="B08BC56F962F289F" modified="2019-01-16" version="1">MPETLRLAVSQSYTLSTTSETLQALEQTVRTASSQSVDLILFPEAYLGGYPRTATFGAAVGARDPNGREQFLHYFKDAVDLGDTPEGAGQKWVDRELAKPKEGIRGDGTREELERIARETGVFIVTGLVERCGGTLYCGAVYVCPRLGVIGKRRKVMPTGSERLIWGQGQPSSLRAVTTTIRGVKLTLAAAICWENYMPLLRQSLYSQNVNLYLAPTADARDTWLPLMRTVACEGRCVVLSANQCMTKANLPHWVTGQSQQENGSNGHTKLPERRLRRQSTVTEDGHEIALPGPKESIASSPFSKPNDSDFVCRGGSSIVSPLGDVLAGPIWDDEHGLLVVEVDFEDCVRGRLDLDVGGSYSRNDTFKLSVEGLDLSPPP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZG2</accession>
    <name>A0A3D8SZG2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_02867</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZG2"/>
    <dbReference type="OrthoDB" id="2399539at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="361"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW91702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="741" mass="82868" checksum="4409CD8C324223D9" modified="2019-01-16" version="1">MDSLSRPAPKLARGVTACQRCRRRKQKVNQKILSSRKKHLTDNWVNTQCDLRHPNCSNCENARVSCLTYHSGKRIEIPRDYISDLEAQVEKLKQENQELRARSLPQSNGGDYPSLEPSFPAIRELSTTPTQDAATSDGTSRYLQDLVKSVRNVVVEPTRQPRFLGASSGITLAKMVMASIRTDALPASALFFKPGSRDQSSSEFASASASGFASGSGSGSAPSSTSALASASVSSLPPRHAADHLVEVYFQYRTPHLPIVERSQVQEALQSAYLSMNGQQTLGRVVERDIFTTYMIFAISLCNVPNPSGGTGRVLQSEGCFRSAINNIEKVITYSKSDLETLRAILLLAQFVSMCPWQGSLWHLSGIALRLCIDMGLHWETEGQSLNIDPALLYDRRRLWYSTYHFDRVLSITLGRPFGIIEESIQVPLPNPWAASHRPLMQETTDFDIHYQRAHNHLFSMAKLESEIKHVQQSQSWPAKIACPKPNFATWIQDIKPRLQEWYSTIPNPSSAHISSIFSNQAYWDTVYNNSILLLYRPTSSSQYQSVEELSIPYEAACKVIASIKTLQREGKLDVLWRSVHHLFMAGLTVIYALWQSKELRNRDSISSSVATLQSCTSTLSAMSETFHGAAGCRDVFDTLSSATVDWLVTNNSEEIRQNRVAFERQVEDLLQQLQPSHGEIFTTVNSANDMSTIFSTDNFAFGEMLNYAAQWPELQNMEFNEIGLDQITGTGFQSGSHSFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZK9</accession>
    <name>A0A3D8SZK9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Fucose-specific lectin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_02844</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZK9"/>
    <dbReference type="OrthoDB" id="5396810at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.70">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89372">
        <property type="entry name" value="Fucose-specific lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW91679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="476" mass="50044" checksum="6F1CF11546618B17" modified="2019-01-16" version="1">MASQAHYGPIPPSYQVHPGHDLPQVADEDNYPEVVPQEHYPEVTTADAVKHNVPYPVDQKADLNPVSEGPVGNGVERRVLGLKRRTFFIVLAVALLVVIAAVVGGAVGGTVNKSKNSAAQNSSNGTSTSPSSNATTTSTDLMLNSSIAAANWTDTAGYVHYAIFSQSTTAAILTSVWDSQNETWTTIDIFAAIQTTENYVLTAKAGTPIAVAAKALGGVSIAVYYLAPNNQIQALDCLDTQGLSNWTRGKVNDASIVAGANSQIAAMWYICDVGCGAGNLMVTYEDASGVLTAANSSGWTTSTIVTVIDGSGLAMTPQVAGASTTGYANYTQMRIFADISNDLQEYTYSPTANSGQWTLGENVSSNTSTVAHQIAAVAFAPLSFVLAYCLFILRSPKGDGGITADYWNGSAWSSDFTPSMSGPDGITATSNFTSIAMNDDFQVFGYINGSVHTWNYTSSDPTTWSYVGLVNTTLSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZM0</accession>
    <name>A0A3D8SZM0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Rhamnogalacturonase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_01138</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZM0"/>
    <dbReference type="OrthoDB" id="2268901at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046576">
        <property type="term" value="F:rhamnogalacturonan alpha-L-rhamnopyranosyl-(1-&gt;4)-alpha-D-galactopyranosyluronide lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF19">
        <property type="entry name" value="PECTIN LYASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017609140" description="Rhamnogalacturonase A" evidence="11">
        <location>
            <begin position="18"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW91744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="47174" checksum="EB68099373DA48AD" modified="2019-01-16" version="1">MLYSILLGATLVAQACAQLTGSVGPLLSAYHKGNVKVCDIRNYGATSSADVGPPIVAAWTACAAVGGLVYIPPGSWPLRTRVDVRGGAGNSIAIQWDGTIYRDSTTMTYQMFTFTNVNDFELFSGNSKGALQGYGYQYLSTGTYGVRMMRLVGVTNFSVHGIAFVDSPSYYIVFDTCSKGEVYNLILRGSTTLGATDGIDVTGDNMWLHDIEVTNGDECVTVKSPASNFLIQGIYCNRSGGTAIGSLGLDTAIENIQYQHLYMNEADACFLKSNGGSGYVTNVSWRDVTVHGSAYPLTIDLAWGTDNGGPGITVSNLEWMNYFGYNDVHTRAAIRLQCSDSAPCYGLTLNNVHMWTSDGGVVTYGCTDAYGVGACMVNKPASPKPAAYTSVQSVTTTSSLVGAATMAADFKTALSPTGTIAIPAIPTSFYPGQTPQSALLALTTVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0T0</accession>
    <name>A0A3D8T0T0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_01538</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0T0"/>
    <dbReference type="OrthoDB" id="5086080at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012:SF7">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="112"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="502"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="56"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="532"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW92144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="557" mass="63593" checksum="F475DE51C88F9067" modified="2019-01-16" version="1">MSGRSDEGNINSADSGGTIADRKGRVIDDDHPSARTAAAKRMKKRELDRKCQRMARDRTKARMAYLERLVEDFQQQDSSGQIAALMSQLAEVRKERDTLVQTLQSIAKLSKNYQEPPAHPPTPHDTDTAHVQQPQKHTAPVMSENTKRLTLHSTIPPQDNRHLTGPTQRVSDIMRQDETSFGATLTFPWETGMVPTVAGFEMGDYGMGDLPNTFPEMVINTSDAEIPPTTTQLQHWEFVIPQSEEVCDCSTPPYIKPPTRRQNQWRFANEILTSTTAPHTRSLIQKEAQGLVEDVLVRAIVDGWESVESELAQFPSWQMLRKIDEEMFCSCSKVERLAVMRAMGLLIAYHATNTPDRAAKLPWWYFKEDLPLQAPISHSYAVEFLAWPALRRRMVFSQHRYCANTFWDLFRANFCVIWPYELRDCFTRDRETGAYRISPAFDTQLQDIRTWSMGRQFFQEYPELYSDIPAIDHIPGHISDPIMALCNPGHQQAPQRRLIQQQAHYSRSKRQDGTNVNPKNPPGREQIEPVRRPSISSNNLPRSLLLSSNSPTSNAYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T186</accession>
    <name>A0A3D8T186_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_01729</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T186"/>
    <dbReference type="OrthoDB" id="1001765at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00657">
        <property type="entry name" value="Ferritin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052965">
        <property type="entry name" value="Pigment-catalase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31694">
        <property type="entry name" value="DESICCATION-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31694:SF26">
        <property type="entry name" value="OS05G0151100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW92335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="307" mass="31776" checksum="E74B0D204D7400EF" modified="2019-01-16" version="1">MKYSFAVAALGASSMVSARATSPIVKRQAAITDVDILNYALTLEHLESKFYREGLANYSQAAFIQAGFPDPFYKYLEEVSFDEDTHVSFLAGALGSAAVAECTYSFPSTDPASFVALASVLEGVGVSAYLGAAASIASPAYLTAAGSILTIEARHNAYIRSALAQIPFPQPFDAPLTFNEVYTLASSFIVSCPSTNAALPVKAFPSLVLGTKGAIKSGDTITLLTPGYMLVPASGVGPIYAAFIAVTGPTLVEAYPVDGGFTVVVPAGFNGQTYVVLTGCKDSVTDDSISAGPAIIEITNASPSKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1L1</accession>
    <name>A0A3D8T1L1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_01818</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1L1"/>
    <dbReference type="OrthoDB" id="3066029at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000354">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF64">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G11760)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="364"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="435"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="68"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW92424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="527" mass="58205" checksum="88766FE8209A3BE6" modified="2019-01-16" version="1">MSPNHLEADQDDRDSIHSNGLHHQDTALTHMPSHMSHTHDAPMQPYTSYIEVPDEIYDRLSPGRKHVIVALLSFCSFLAPISSTTILSAVPEVVSTFHSTGTIINLSNALYMLGMGFSPCFWGPLSQVYGRRMICLTTAILFLGCSIGTALSPNLVAYFIFRILTAFQGTSFLTIGAACIGDIYRPSERATAMGWFLSGTLIGPAFGPFIGGIIVTFRSWRVIFFLQTALAGVATIGAYFLLPETIHHKKADDLIGLSRSAKARVLWSMLNPWRVVRLFQYPNLLIGSLASSSLVWNMYSLLTPIRYVLNPRFNLTSPIQSGLFYLAPGCGYILGTFFGGRYADHITILWTKKRGGQRIPEDRLRSCIPFLGIVIPTAMLLYGWSVEKKFGGIALPVIMMFCQGVAQLFCFPSLNTYCLDVMQGNSAEVVAGNYMIRYLFGAMGSAVVLPAVEKIGVGFFSTISAAFLVLSSLGICASVRWGPSWREKIDTKRRAARQKSLKEHEAEKDFVVTEKAVAQQEKEKDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1P9</accession>
    <name>A0A3D8T1P9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative lysine-specific permease protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_01889</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1P9"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000001">
        <property type="entry name" value="Amino acid permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="315"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="41"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW92495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="554" mass="60028" checksum="CF87BA87FD79ADE2" modified="2019-01-16" version="1">MEANTHSKSEELFTDVKDVGEGEVAGQRWGQETKRGLKGRHLSMLAVGGTIGTGLFLISGSTISTAGPVGAVIAFIIAGIFVYLVVSTIGELATVFPISGSFAAFSDRFFDPALGFAQGYAYWFLWVLTLPAELSSAGIIISYWAPDIGTWVWALVFLVMIVVINLFGVKYFGEAEFFFSFLKVLVVIVFILVGLILNGGGISGHPARGFEYWKSSTPGAPFADGWPGVLSALVTAFLSYGGTELVGLTAGEAKNPRRDVPRAIKGTIGRILLCYVGSIFVISINIPSTDSSLLSTSAKKIAVSPFTLVFKDAGIAAAASIMNAAILIAVVSAGNTSVYASSRILFALAKNGQAPKLFTYTWGWNGTPIAAMVISVAVGFVAFLGDIFGQGVVFTWLYNLIAICNLLIYMSQCLVHIRFRKGWIKQGNDPKDLPYKAAGYPYTSIFAFLMGCLIVAGEGYVAATTRPFAWANIVATYVGVPFFFVLYILWKVIKKTKMIPYEDMDFMTGRSYPPTDEEIANLKERKQMDMRPWKELSAKGKAIKAGRTAWRTVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1U3</accession>
    <name>A0A3D8T1U3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_01894</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1U3"/>
    <dbReference type="OrthoDB" id="5423360at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46310:SF7">
        <property type="entry name" value="AMIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="245"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW92500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="678" mass="74716" checksum="D7C29B4BEEF98A2F" modified="2019-01-16" version="1">MAMEEGNPQSYTTRSQDESNLHTMAEPALPNDITVELDGVQYLIHPKPIAELEILHLPSDLNPQSISALPESNSRQATSWLPVTVINSSDRLFSDNTCVPRPYLEDELQKMQELDDVLIDTFTQTVICLIPSDAAPALTPISSECKSSRKVRFAKSRQDEELYSAPYFLQGDHLYKAYRLYPDTYGAFISGIFESIPGHLEEALGSTHQESALSSLRDLHKTNGNLHSYQEIQSNLIPIPSRLYSHQPGSNPQKPLSGQRIAIKDIFHICGLKTGAGSKDYRSLSQPATYTAEAVQALIDAGAVLVGKTKTVSFASGAAAADWTEYECPINPRGDGRLDPDCSSTGSGVAMAGYEWLDFSIGSDSLGSMVGPAAANGVFGFRPTHGLPFPPSAKDGILVSRLLDTVGHFSRSLPGLEILARAWFPGSKLESGIYRGVRRILVHPELTTGYEQKEDNVIKDFILDFERIVGLSAESFDLGASVLTPLDESYPGMKWSEYLSNTMANIQLYDSYHNSLGFDQQFRDRFNSSPSLEPIVAYKRELARETVSKAMYEDECSRMEKFREYIQTEIIVAGTVMLLPIIGVKPSFIDTQPSLKALIAKQDARPWTELLGERGRRWQGFGFRSTAVSVLGGLPCVSFPVGETPYDGKSGAQENTFNRPINLMIVGAPRKLSLIYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1U7</accession>
    <name>A0A3D8T1U7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAS1-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_01930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1U7"/>
    <dbReference type="OrthoDB" id="7700931at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.180.10">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050904">
        <property type="entry name" value="Adhesion/Biosynth-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036378">
        <property type="entry name" value="FAS1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000782">
        <property type="entry name" value="FAS1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900:SF125">
        <property type="entry name" value="FAS1 DOMAIN-CONTAINING PROTEIN YLR001C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10900">
        <property type="entry name" value="PERIOSTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02469">
        <property type="entry name" value="Fasciclin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00554">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82153">
        <property type="entry name" value="FAS1 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50213">
        <property type="entry name" value="FAS1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017835440" evidence="2">
        <location>
            <begin position="20"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="139"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="domain" description="FAS1" evidence="3">
        <location>
            <begin position="280"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW92536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="478" mass="52680" checksum="4BDB519086B27AE8" modified="2019-01-16" version="1">MKLIHVLPLAALTSAFVLPDEQMTSQMIIQPKEASKSILSKLPTLSDIKDSVKEIVEVSGNALDNAFHAASHYHEKSKSSFSCFQSMTAFDVKGWLESGEYITDDFIDHEDEDHPHPPHHRPDHPPHHKKPHHGHGKPNLTVYELIAKSKYTTKLAKLINEYPDLVETLNGTAANYTVFAPTDKAFAKIPKDHKPSKEVIKKILAYHVSPDFYPAGRVLVTHTIPTALGEDTLGGEPQRLRVGLGLRGLTVNFYSRIIAVNIFGTNGVIHGVDSILLPPPPSLKIISLLPGDFSTLSLGLEKTGLFDAIKKAPHEGGTFFAPNNWAFKKLGTRANAFLFSSYGEKYLKALLKYHVVANQTLYSDAFYKAKDALASGELESAGIPKGRFHIDLPTLLDDKSLAIDVVRFGGIIQIRINGFNHIAVQDGIARDGVIHVLSSILIPPKTPGGAHYMGEEIEVEDLKERLDNHFGKDIIQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1Z6</accession>
    <name>A0A3D8T1Z6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Required for respiratory growth protein 7, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_01412</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1Z6"/>
    <dbReference type="OrthoDB" id="20734at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018828">
        <property type="entry name" value="RRG7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28133:SF1">
        <property type="entry name" value="REQUIRED FOR RESPIRATORY GROWTH PROTEIN 7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10356">
        <property type="entry name" value="RRG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW92018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="24544" checksum="8F718A8AF4993993" modified="2019-01-16" version="1">MLLARFSRFKRCQEQSFRTYSTFTDSEALIYPESRTPSHHDLPSFLEYARRSELDTSSAVYVGTHYEYTVQIALQRLGLSLKRVGGRSDYGTDLLGTWDLPSLDQPLKVLVQCKALARKAEPAQVRALEGAFAGAPPGWRGSGVLGLLVTQKSATKGVREALGRSRLPMGYVLCGPDGKILQMLWNRRAEQEGLEGIGVSLKYSSDQDDKEVVLTWKGDTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T3L5</accession>
    <name>A0A3D8T3L5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Pectinesterase</fullName>
            <ecNumber evidence="4 11">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_01982</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Involved in maceration and soft-rotting of plant tissue.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 11">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1-&gt;4)-alpha-D-galacturonosyl](n) + n methanol + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22380"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14573"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:140522"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pectinesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="4 11"/>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T3L5"/>
    <dbReference type="OrthoDB" id="1546079at2759"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000014">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033131">
        <property type="entry name" value="Pectinesterase_Asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF127">
        <property type="entry name" value="PECTINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00503">
        <property type="entry name" value="PECTINESTERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="11" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="7 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017495680" description="Pectinesterase" evidence="11">
        <location>
            <begin position="18"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="12">
        <location>
            <begin position="30"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW92588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="332" mass="34822" checksum="736A2722E8047623" modified="2019-01-16" version="1">MLVLSTFFAALLPMVLAGSRTTAPSGCLVVSKSATSGQYSTVQKAVTALSTTSTCAQCIFIGSGTYSEQVYIPARKAVLTIYGETTATGSYTSNTVTITHKAALANSANDDATATIRNWAANTKFYNLNIVNTYGQASSNGQALALSAYASGQGYYGCQFSSFQDTILAEKGLQVYAQCEIIGAVDFIFGQSAQAWFHKVDIRVLATSFGTITASGRDSSSSSSIYVINKSTIAAKSGVTVTAGSYYLGRPWEPYAKVVVQDTSMTAVINSAGWTPWSSSVSTANVVFEEYGNTGTGASGTRKIGKKISSPVTIASVLGSSYATWVDSNYVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7A9</accession>
    <name>A0A3D8T7A9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cytokinesis protein sepA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_00084</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the formin homology family. BNI1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="1104827at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005934">
        <property type="term" value="C:cellular bud tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000131">
        <property type="term" value="C:incipient cellular bud site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043332">
        <property type="term" value="C:mating projection tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051017">
        <property type="term" value="P:actin filament bundle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.150:FF:000003">
        <property type="entry name" value="Cytokinesis protein SepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.2220:FF:000006">
        <property type="entry name" value="Cytokinesis protein sepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000291">
        <property type="entry name" value="Cytokinesis protein sepA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.30.50:FF:000001">
        <property type="entry name" value="Cytokinesis sepA protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.30.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.150">
        <property type="entry name" value="Formin, FH3 diaphanous domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051661">
        <property type="entry name" value="Actin_filament_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014767">
        <property type="entry name" value="DAD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010472">
        <property type="entry name" value="FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014768">
        <property type="entry name" value="GBD/FH3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010473">
        <property type="entry name" value="GTPase-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47102:SF2">
        <property type="entry name" value="PROTEIN BNI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06367">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06371">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01139">
        <property type="entry name" value="Drf_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01140">
        <property type="entry name" value="Drf_GBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51231">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51232">
        <property type="entry name" value="GBD_FH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GBD/FH3" evidence="6">
        <location>
            <begin position="272"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="domain" description="FH2" evidence="7">
        <location>
            <begin position="1110"/>
            <end position="1531"/>
        </location>
    </feature>
    <feature type="domain" description="DAD" evidence="5">
        <location>
            <begin position="1545"/>
            <end position="1577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="109"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="893"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="979"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1249"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1519"/>
            <end position="1739"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="733"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1400"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="135"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="154"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="893"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="939"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="991"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1006"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1020"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1058"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="1077"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1262"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1535"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1652"/>
            <end position="1673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1728"/>
            <end position="1739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00037935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW94321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1739" mass="193222" checksum="88670DC2C95EE5C6" modified="2019-01-16" version="1">MSTGDSKSRQSSASKSFFSRSSKKDKRNVSDEGKYLGGDLDKPVSAGSRTSRHTRGSSVASIDRPITPGADSSGIAMMSGVITSIPYESMPADSKTPIPVEYLPRGDQLPVRREPLPHHLNKGGGDFHQYPSFDPSASPNGSSHPSGPRPPPVNNQTMASTGSRSAQLQQWGPSRGSVTSTSNGAHNSRYDSYSTNNSSYGRNSFEDSSTERSSVFSSGSSSRTAMQSTYSNNSLSPSHATREGNRMTKFPHHTSGGFTSTASFAPDGFNLAKPTDERVIEEQFLALMQKRGWHNLPEQARRQMMAYLPEKKWTLVHQDRLTEWQGEQKRRTTASRQTGQYGSAMEMLANAEEEGTPEWFVKKVMDNSITTKQLQSLAVSLRTQPISWVKTFVECQGQVALTNVLGKLNRRQAQGPAPAEGSTKDKDLDREYDILKCLKSLMNNKFGADDALNHQQVIIALVTCLISPRLTTRKLVSEVLTFLCHWADGQGHLKVIQAMDAVKTQNGENGRFDAWMRVVEVTVDGRGKMGSMVGASEELRSGGIGMENLLMEYAVATLFLINMVVDAPERDLQLRVHIRAQFTACGIKRLLTKMEGFQYDVIDKQIERYRANEAIDYEDLLERENSSMKDSVEGEVKDLNDPAQIVDAIMQKVGGSRTQDYFVSAMQHLLLIRDNESEERLRMFQLVDNMLSYVAMDRRLPDMDLKQSLNFTVQSLLDKLHTDSEARQALDEAVEARQIADSAMAERDEMKSQIELGADGMVAKLQKQLNEQAQIIDVQRRQADALKGEVESLQTVRAKEAQRNELETRELYLMLRDAQDIAASNAAKGIKALGETQPAQMKGILDRERLMDRLEMQIERQKTQYKLEGRVWGDAAGPSDRLRALREEMDGEAAGGVAGGEGGIGGAQLGTPPRDYTNSILGATKRIPRKAVNSTGSLNEDDEEDDDGTVYEKPQIIEMRRPKKVPSYMNDIAKLKKYDASDDEDGDGVTTGPSHPSLESQSPRTPNDETAPKVDKPSFNGPPPPPPPPPPPAQMGFNGPPPPPPPPPPGKGPGFTGGPPPPPPPMPGSGQASPHGSMPPPPPPPPPMPGKMAGKFLVSQPSYNAVPTLGLPVARPKKKLKALHWEKVDTPVTTHWAAHAPTAAEREEKYAELTRKGVLDEVEKLFSAKEIKQLGKGGSKKAEKKQIISSDLMRNFQISLAKFSSYPVEKVVQMIIHGDKEVLDNAVVMEFLQKEDMCNIPENTGKLMAPYSKDWTGPDANRGSREQDPTELTREDQIYLQTAFELRHYWKSRIRALSLTRSFEPEYDEISEKLRQVVAVSESLRDSVSLMNVLGLILDIGNYMNDSNKQATGFKLSSLARLGMVKDDKNESTFADLVERIVRTQYPEWEGFVDDIGGVVTAQKLNVEQLQQDAKKYIDNIKNIQMSLDSGNLSDPKKFHPQDRVSQIVQRSMKDARRKAEQMQLYLEDMVRTYDDIMVFYGEDPSDENNRRDFFAKLAIFVTEWKKSREKNIVMEITRKRNEESMKRKQIKMGPTSSDGSAPNSPVSTGAMDSLLEKLRAAAPQTRDQRDRRRRARLQNRNQVRVASGQKVPDPEEIPEIEIGLKSPDSVSTEGFLSPEMRMDQADDDVTERAALLLQSMRGADGADDNDTGDRRSAERRSRRRETAEEERRARRRRRETAKSNTSEGPSIPEEAEPVPEVPMSPSTDDGEKVLTPTTIVSPPSPEGTEKKPIEVVDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7G3</accession>
    <name>A0A3D8T7G3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_00243</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7G3"/>
    <dbReference type="OrthoDB" id="5430812at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050897">
        <property type="term" value="F:cobalt ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015087">
        <property type="term" value="F:cobalt ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46494:SF1">
        <property type="entry name" value="CORA FAMILY METAL ION TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW94480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="529" mass="60173" checksum="A91D0F5DB0B128F8" modified="2019-01-16" version="1">MAPVPHRFRNFDDQAVFEDSQERATKETTRNFVVEFGKNEAQVAFDLDANHIADLLKTERSLERPVRWINIWAPNQQVDTVEVLGFHYKFSPRLQAIIRTVPEPSHPAKDLKVEHRFRAKTFPKNDPEVAEKSIDLPTTAIPTRIRSVNTSHYEIARQMVSYQSVDVGAHFLCIGANWMHQAPKPKSKDDESIVPVDAHRRLWSWLILCDDRDTVISFHEDPGVVGDVTETHLLRGNVLSVFCQLSQHGHEGADPVSMQSVRQALPESASYNAGIEGASNLFYYLFDDWRAVYASLSRFHKRLEALQTSIFGNLTKKSNSTPDMSIIPSLHMLGRDIRVRQHLYEGYFNLIQRILGPSDKSVHESVTYSAMQGHNGVVVAPSAHQRFERLGDRLQLLILSEMREFLVEKDALISTYFNINAQKDSEATARLTRSATLLAKLSVLFLPVSLMTGYFSVQINDLAGVYTARDYWSAFAVIMSISFISIFLLSKSLMWITETLEAWVKSTTKYCKKAVIGRRPEIDVEEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T882</accession>
    <name>A0A3D8T882_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxin 11C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_00498</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Peroxisome membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T882"/>
    <dbReference type="OrthoDB" id="10005898at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016559">
        <property type="term" value="P:peroxisome fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008733">
        <property type="entry name" value="PEX11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652:SF25">
        <property type="entry name" value="MICROBODY (PEROXISOME) PROLIFERATION PROTEIN PEROXIN 11C (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12652">
        <property type="entry name" value="PEROXISOMAL BIOGENESIS FACTOR 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05648">
        <property type="entry name" value="PEX11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="1" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00046271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW94735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="34816" checksum="A299F6857322828B" modified="2019-01-16" version="1">MSEIQGMAPPDTSPENAIPIPSANPPHAPSVDTLKSWLPIYLSKSDVAIRRLDKILSTPSGTDRLLMTICYTSLLTSNVLSSISLARIQQTTRSLIEKAISLPPNTTLVFTPAPSRTTAHLLATSVRLKKLSALISDFRIFTRMWGLLGLYKWGKSSLENPPEDTVLRRITYAQVFVNVLFQYLENAAYLSSKGIMGWDTKKQNRAWEWSSRFWAAHVGLDLGRLCYEWNVRRRRDLKGKEKDEGEVEQNDAAWRAKWRREMVVNLAYAPLTIHWSLEQGLIGEFWVGLFGSVAGVTALKELWKQAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8V6</accession>
    <name>A0A3D8T8V6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PLC-like phosphodiesterase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_00762</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8V6"/>
    <dbReference type="OrthoDB" id="7984201at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051057">
        <property type="entry name" value="PI-PLC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13593:SF146">
        <property type="entry name" value="PLC-LIKE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26146">
        <property type="entry name" value="PI-PLC_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017556011" description="PLC-like phosphodiesterase" evidence="1">
        <location>
            <begin position="18"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW94999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="295" mass="32150" checksum="8F00B1D921C27835" modified="2019-01-16" version="1">MRTAIASLLFSVSAALAQQLCNGYAELCDRKFSNITWLGDHDSPFIGEFLTDNQALSVADQLAGGVRFLTGQTHEWLDQGYLWMCHTSCWEEESGLLTTYLETIGTFLDANPDEVIFLLLTNGDYVDVSIFGTAFETAGLTDLVFTTTGTLAMDEWPTLGELISNGTRLVVFLDYDADVATVPYILPEFDYFFETAYDVTAQSDFSSCALNRPSGSDGTGLMMIVNHFLDVDVLGVDIPDFAEESVTNAATGTGSIGAQAAVCLEEWGRLPNGILIDYFKTDDGALTAYKTLNNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8Z4</accession>
    <name>A0A3D8T8Z4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PA14 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_00241</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5431204at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017577068" description="PA14 domain-containing protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="4324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW94478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="4324" mass="461418" checksum="EC9380583D73317E" modified="2019-01-16" version="1">[encoded data, 4324 characters]</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9H5</accession>
    <name>A0A3D8T9H5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_00937</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3548913at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42064">
        <property type="entry name" value="YALI0F28677P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42064:SF1">
        <property type="entry name" value="YALI0F28677P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="666"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="753"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="813"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1157"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1320"/>
            <end position="1411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1504"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="666"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="684"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="762"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="780"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="820"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="840"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="854"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1188"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1326"/>
            <end position="1338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1339"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1357"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1370"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1380"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1509"/>
            <end position="1527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW95174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1738" mass="194382" checksum="F6C8CCC020DE19F5" modified="2019-01-16" version="1">MQRSLSLPGPGHSSPPVSPIVTHVSSKSTTPLPFENGAIPPRLHQFQSRSPHRSDRPPSSHKNKPVDLERPRRSNREPSPTPATRRPSISSQSPSKSSFSTPETVIASPTKAPPLPLLQDVSQYLNTQINEVTAPTATTSLEELAHLVRLSTYQERKCTHSRVRLHRSLVSTALSARLARCGDLAHRTLVDNFRGDEKKSFASLYNAIHDVRNSCDATRRFALLEPDLENGRPNSDGGQDPSVLSTFMHEIPQRSRDTLLAFLTQIRTNPDYLASRITSLTPTELAALTVFHQGLDPIDSVLPFHTRSKGHASNTQRISTHIPPPVERLLSFQRHDPLCALIHTCFANSAGPESEEDLRRTEVWASTCARMITHSKSGTDSFICSVLNVWTAMRDWSGRSNMEWYLMKILEDGAFLLDKAEDQAGTRIHVEPRNAKDSIAADEFYDAAIIGLFEVVDDPGAGGIPEGLIELGNAILRRLDAKYHSTTRKFLVSKWLFSVFLFNAIIHPESYGMMSEYHITEYGRQKILKEVAMRAQRFVVDLTWNKSPSTPPVIKMHIENILARFRPSRPSRSKARLVPARSLTSLRETVEVHPYLVLGPADLTTIVNALFPEKRPVSSSLERDIHFNGLRSAASSISGISAISAQVTGPQARNAFDNVSIISNSGSSVVSDTTTSREPLLDDSSSGTQRYSSTSVSSMAPSSRASYYEDDGYKLRLALHEMTQTLGADVVSGACHPCAERWTILFMSPDGQTLSTQMMHDPDDDEHEEETTSDSESEDEFRSSRPDLDKDYHQLRDSILKLVEDYEIPQSLGSREEAKTFSNRTSTLESPRKKAHRSRPGTSSSAQSKNPYLQRREPSPEKQPGSDEGRGSSRHRTDPENTKHHGDGERPSVLITMLEAAEAQCQAQSDFVNAHLYWKTLNQLNQLSSQSLKRDGYASLLSIFSRGPRDSIRRSTSAIEEYDAWLVWLKQSQERHDTTIESMMKRLRALRDKMWYVTDVRNSAAYEGARNIAVALKTMASPKVNRFLLPAHIRPRNISRTSTNNFLLKTEAQVMDMMAAVEDQGGPNKLSDEQSEKTLRWLSQFGIENFCRGEERIHRFCLEIEACINKLVGDNLIDGPVLWSSELFYRDRRILDSGRQKGDLFVNGLGSLNLSGDDLNDSDPSRRGMRNTDFASTRNSGLRAMSARNGSQQSFDSGRFSSISRMSATGDLMDSQDYFGMASPVLTIDSATTFWSPFQTRAQSPTTSISSARPGTSSSTNETIMMKDERAGMSKQKFLIELKQTLTSLLISDLGTLVFARGSETDSWFSGDLGQDCMERRDKTDRKTRRRSKKRVIEKKKSFRDLRNPQKTGVSSEHSEHGERMEKGLSANTRSSAGQSASEVYSTTESSTTNEVLGNSSRRTASKDLDSPEFPYRKAFQRLLRMFSVHPNPYVKLNALFELEHLIIAYLTPSTRRPRLRPQSLSATTQPPDVQQQVNAFGPSENPATPRAKNIGEAIDNCNHRRSQADPTSPIHQTAERSQSIPNPASTDMIVEVLQDLFRDADIRPKTLFRDLQFIASFVPAMVLDKTERGKAFWDAGLAALGLKQDVCRTLIEIADEVVVHYTDSRKTTSSHNLPESQPQMGELMKYSMQDAAKMWTITAKEGDPAAERELAIFYLTHPELVERVTAPLSKPRETFKAQVMEMHGPPSVKDGDRERSDPATMCVAYHWMELSALGGDELAKKYLRQREELNAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9K6</accession>
    <name>A0A3D8T9K6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_00989</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9K6"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000188">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF50">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G00840)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="327"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="356"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="450"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="62"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW95226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="508" mass="56401" checksum="AB577181AEA3F930" modified="2019-01-16" version="1">MAVHKTTSPSLSSRGEAVDSKDAYHVNQNADPEATLEAHNEPPYVVDHAAERALCRKFDFRLLPVLAVMYLFNALDKGNLSNAKTDGMDTDLGFKGNQYNIILSVFYVPYVLMAPVFGMVGKKYGPARVLPLLMTSFGSWTLLTAAAQNFGGMLTLRILLGMSESAFFPLVIYYLTTFYRRGELARRLAIFYAASNIANAFSGLLSVGVFQIKNTSLYPWRYLFLIEGALTFLFSIFAFFYLPSNAAAARFLNDNEKALAYHRIQVDSSSVVNEEFNLRESLKIFKHASTYAFLGIEVCLGVPLQSVTLFLPQIVARLGYNKIKTNLYTVAPNVTGAVMLLVLAFSSDYARLRSPFIVLGFVFTFVGFIIYATIDVEHDINLAYFATFMMCWGTSAPSVLLSTWYNNNVAHEGRRVVLTSVGVPLANVMGLVSSNIFFPSSAPKYIPALATTAAFGATGACLAALLGLYMVFDNKRRDRKLGRKLDIREVPTELLRDGPTVPEFRWFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8TBU4</accession>
    <name>A0A3D8TBU4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNase1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_00961</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8TBU4"/>
    <dbReference type="OrthoDB" id="3513524at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017631592" description="DNase1 protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW95198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="19365" checksum="6E46ECAE78825EA0" modified="2019-01-16" version="1">MQFTSTLLFAASALVASVSAANVVHFHNQDSTTRTIYFAHNPGMEDIEAVTISGLNTIKNVTFPDGWTGNFHSVSEGAANVTGMLGEVMFNGYAGATYFDISAIVNPDDDQGVKILKPLSSDTPLSGCQTFPCSNAYNLPDDIATLATDDTELICLLGTLTSSKRSTRQKRYDHEFVAGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q483</accession>
    <name>A0A3D8Q483_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cytochrome P450-15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_13116</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000025">
        <property type="protein sequence ID" value="RDW56651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q483"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7 8" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="248"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="450"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW56651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="519" mass="59571" checksum="07EC5B667F6C81E5" modified="2019-01-16" version="1">MDILITIGATQALSFAAVGLVLWTLYGAIYRLYLSPISAFPGPKLAALTFWYEFYYEVYPLYGQYVFHIRDLHEKYGPIVRINPYELHVSTPQFYETLFSSTKKRNKWYWFTRIFGKDGAAFLTVDHNLHRARRAPMNPFFSIASVRRLQPMIDERVQTFLGRLSDLRGSGKILKLPVVVNAFSNDVIMMYTFGRSYNRLEVPDFDPLNHELMHEGSKTLTVMKHLIWIFRIVQSLPEFMLSHMGYELAALVEQKNNMRKQVKQVLQEKNDAHKDLLHPTIFHALIDSDLPLEEKGVERLTDEADTIIAAGQETLSLILTFITYHLLSNPTMLQTLKEELAKVIPDPNIVTPVATLSNLPYLTGVIKEGLRLGYGVSGRLHRVPLEPLSFSAPGHEWVVPPGTPVSMTSVLIHHDESIFPNSYEFQPERWIKNSGLDRYLVSFSKGSRSCIGINLAYAEMYIWLAGVFRRYGSSDVRFKTDEGVLELFETDRSDVELWADRFIPVVKPGSKRVRFRVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q535</accession>
    <name>A0A3D8Q535_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000024">
        <property type="protein sequence ID" value="RDW56923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q535"/>
    <dbReference type="OrthoDB" id="5215637at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW56923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="275" mass="28860" checksum="79C6006EA5669661" modified="2019-01-16" version="1">MTCYDNTGKLASDNVPCNPNAAVSACCGIGSVCVSNLYCYDQFGDNVPGTCTDETWSTGNTPGCPCPPVYVGNGALNFASGVTLCSDGSYCCGQANTDCCVQEKGFSEISYNQPATISSGAAALFTYYAGVHVSTKPVVRSSSSTTSTKSIFPAFSTSSTVTVATSSSTPKTTKSPNGLSDGAKVGIAVGIVLGLIIISVQAFYVFKLRRTRGPSFYQPSKADVSGIRSQFEDGHDQSIPAVHSQEPTDDLVRHDAFRRVTELSGSNQHPYEMHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q657</accession>
    <name>A0A3D8Q657_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_12741</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q657"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001638">
        <property type="entry name" value="NACHT and WD40 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NACHT" evidence="5">
        <location>
            <begin position="373"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="902"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="944"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="986"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1028"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW57291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1084" mass="121232" checksum="0B81F6CA478CE831" modified="2019-01-16" version="1">MRKYFEARRQKPAPPTVSAADSSQAQGSSGNITSEAEHPSKAPSFPDGIKVLHNCPDATVDICFVHGLTGDREDTWTAYGQTIAWPKTLLPPKLPKARILTYGYDAYVVRKSVASSNRLIDHAANLLIDLTADRAECNLSSCPIIFVTHSLGGLVCKKAILLSRNNPEVHLRSVFDCTKGIIFMGTPHRGSWMSDWAKIPASGLGLVKSTNTSLLKVLETNDQLLESIQVEFLAMIRELGKGAKPIAVTCFFEELPLPVVGKVVSKDSATFEGYSAISVRANHSEMVRFSSAEETGFKRLLGELTRWEAEVSINNTYIMDESDRKCLQSLRLSDPNHDKARIEQTKGGLLQGSYKWILDHKDFQKWLNDERCQLLWIKGDAGKGKTMLAIGIINELNKLNSTSNSSLLSFFLCQGTDAQLRNASAVLRGLIYQLIVKNNCLISHLQAQYSLAGPRLFEGHNTFAALSSILEEILRDRRLKTTYLIVDALDECEEELPRLLDLMSKTASTLSARVKWLVTSRNRHDIETRLAQKNADVRLSLEVNADLVSHAIGFYIDDKVNQLVSIKHDQAIRDEVRNTMRHKADGTFLWVSLVFTELQQAQKYDILEILEEVPKELTPLYNRMISHIRQLKRRDSVFCRNVLSTAILAYRPLHLLELRTLAGLKNNISDIDQERIINLCGSFLTVRDKHVYLIHQSAKDYLTTNASAEIFPDGPGLIHYHMFSNSLTALSQTLRRDIYNIENPRVLVDEVKTPNPDPLALVRYSCTFWVDHLRDCDSPQKQIILLNNEDVHKFLQKHFLHWLEALSLIRKISEGILAITSLEQILNDTKPSDIYAFIYDAKRFALYSQGIIRDAPLQTYCSALIFAPELSLIRRQFADKTPQWLRRQPKVPENWSSLLQTLEGHTSIVTAVAFSPDGKLVASGSEDHTVRLWDSATGTLQRVLEGHTDNVTAVAFSPDGTLVASGSEDRTVRLWDSATGTLQRVLEGHTSIVIAVAFSPDGTLVASGSWDRTVRLWDSATGTLQRVLEGHTDNVTAVAFSPDGTLVASGSEARTVQLWDSATGKLQHRWSAFDYKLGTVKPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q7K5</accession>
    <name>A0A3D8Q7K5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">chitinase</fullName>
            <ecNumber evidence="3">3.2.1.14</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BP5796_12603</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random endo-hydrolysis of N-acetyl-beta-D-glucosaminide (1-&gt;4)-beta-linkages in chitin and chitodextrins.</text>
            <dbReference type="EC" id="3.2.1.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.14" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q7K5"/>
    <dbReference type="OrthoDB" id="73875at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008061">
        <property type="term" value="F:chitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008843">
        <property type="term" value="F:endochitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006032">
        <property type="term" value="P:chitin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00035">
        <property type="entry name" value="ChtBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02878">
        <property type="entry name" value="GH18_zymocin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.10">
        <property type="entry name" value="Endochitinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011583">
        <property type="entry name" value="Chitinase_II/V-like_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029070">
        <property type="entry name" value="Chitinase_insertion_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036861">
        <property type="entry name" value="Endochitinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001579">
        <property type="entry name" value="Glyco_hydro_18_chit_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053214">
        <property type="entry name" value="LysM12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700:SF2">
        <property type="entry name" value="CHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47700">
        <property type="entry name" value="V CHITINASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13720)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01476">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00636">
        <property type="entry name" value="Glyco_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00257">
        <property type="entry name" value="LysM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54556">
        <property type="entry name" value="Chitinase insertion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57016">
        <property type="entry name" value="Plant lectins/antimicrobial peptides"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01095">
        <property type="entry name" value="GH18_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0146">Chitin degradation</keyword>
    <keyword evidence="4" id="KW-0147">Chitin-binding</keyword>
    <keyword evidence="9 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="13">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017533222" description="chitinase" evidence="13">
        <location>
            <begin position="27"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="14">
        <location>
            <begin position="40"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="14">
        <location>
            <begin position="104"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="GH18" evidence="15">
        <location>
            <begin position="247"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1137"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1137"/>
            <end position="1148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDW57802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1164" mass="127161" checksum="E46377A95A740A04" modified="2019-01-16" version="1">MTFYNLPTCAALSRLCLVALIITVSAQPSQIPIQDQGHCRTIQVHSGDSCGSLAQRCGISGHDFEKYNADPHLCSTLQPLQHVCCSPGGLPDFKPKPNPDGSCATYTAKHGDNCAAVGAAHGLTVTDINTMNHHTWGWEGCANLQAEQTFCLSHGTPPMPAPIKGTVCGPQVPGTKPPKDMSNLADLNPCPLKACCNKWGQCGTTSEFCIKTKSSTGNPGTSAPHTNGCISNCGMGIVNNGNPPPVSRSVGYFEAWNMGRPCLNMDASQIDASQYDVVHFSFAEITLNFEVKITDKEQFEVFKKQHGFKKVVSFGGWSFSTSQDSFPIFRNAVTNANRATFAKNVASFVRANDLDGVDFDWEYPGAIDIPNIPPGDKGDGQRYLAFLKTLKSMLAKNKTLSIAAPASYWYLKGFPIAEISKVVDYIVYMTYDLHGQWDYKNKYAAEGCPHGSCLRSHVNYTETINALSMITKAGVPAAKVVVGIGSYGRSFQMTDPACSGPKCTFTGPKSGAHPGICTETAGYISNAEIEDIIAKDKTAKTHYDQSSDSVILQYGNKNWVAFMDDNTRKSRISSYKAKNFGGTVDWAMDLGRFHPPTHGHQGGHGPDLNINSTCIDLEKFQGTHGLTSNMWGFAHAGTYFSDWIHKKWHPGPQSFFMADFATPWGLRESTRSCEVGSNCETPNCGDMGDAADAPSSGPAYMVIVAFYNTMAVLHDMYAAIGHARDEWNSLPDWFQSHFNTNRDVADYNAVPVKEAILGIGTAVSVLLALTGNPVAGAVGAFAGGLAGGIITAIPNPTEDTVKELGQFQKFMHDTLDTAEQSVSSFFTGFQVNGHSQGKGASQDISLEQAFQGGEWVDWSKIPILNPKELNTNKINAVFAKHVSAAAINWAWSRKWDADKRWLNQLITYHDLTKLNTFLTLETQLRSRYTFANLFDQQHTQRVWLMSYPMTEDEFNSHYAFSGNNDSRLKHYYKGRGYFFMSVFPQSAPLQSAKDPRIQDPPGWGNVEQVGITTYQIIESSADGYAIGGYDYDPKPDIAKMLESTTRDLLTDSVSLPGVFNIPVCALDSRYGWTPSVDKFFHALAGPGALLEDNDNGQHAPLCYCIGVKDRFGKKFEDQISFKGWHGYPWCPIGEFNTPGGAPSSTPTPTTEPPPGRTINAKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q7Q0</accession>
    <name>A0A3D8Q7Q0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10 11">Endo-1,4-beta-xylanase</fullName>
            <ecNumber evidence="4 10 11">3.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_12518</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10 11">
            <text>Endohydrolysis of (1-&gt;4)-beta-D-xylosidic linkages in xylans.</text>
            <dbReference type="EC" id="3.2.1.8"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10 11">Glycan degradation; xylan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10 11">Belongs to the glycosyl hydrolase 11 (cellulase G) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.8" evidence="4 10 11"/>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q7Q0"/>
    <dbReference type="OrthoDB" id="2115822at2759"/>
    <dbReference type="UniPathway" id="UPA00114"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031176">
        <property type="term" value="F:endo-1,4-beta-xylanase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045493">
        <property type="term" value="P:xylan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.180:FF:000001">
        <property type="entry name" value="Endo-1,4-beta-xylanase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013319">
        <property type="entry name" value="GH11/12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018208">
        <property type="entry name" value="GH11_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033123">
        <property type="entry name" value="GH11_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001137">
        <property type="entry name" value="Glyco_hydro_11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46828:SF2">
        <property type="entry name" value="ENDO-1,4-BETA-XYLANASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00457">
        <property type="entry name" value="Glyco_hydro_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00911">
        <property type="entry name" value="GLHYDRLASE11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00776">
        <property type="entry name" value="GH11_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51761">
        <property type="entry name" value="GH11_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="8 10 11" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6 10 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10 11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="5 10 11" id="KW-0858">Xylan degradation</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017794909" description="Endo-1,4-beta-xylanase" evidence="12">
        <location>
            <begin position="20"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="domain" description="GH11" evidence="13">
        <location>
            <begin position="37"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="10">
        <location>
            <position position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW57717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="226" mass="24137" checksum="961B8C9DD4C8C6BA" modified="2019-01-16" version="1">MVSLTSILFAASAIASVLAIPAVSPAPGNLLSERTTYITSSATGTSNGYYYSFWTDGTADVYYANDNAGEYQVIWTGDKGNFVGGKGWMPGSARDINFSGTFSPSGNAYLSVYGWTTSPLIEYYIVESYGTYDPSAAGTFKGTVTSDGATYDIYTAERTNAASVEGTATFTQYWSIRRSKRTSGTVTTANHFDAWANLGMSMGTFNYQIVATEAYESSGTSKITVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q981</accession>
    <name>A0A3D8Q981_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PEBP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_12333</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q981"/>
    <dbReference type="OrthoDB" id="2506647at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030414">
        <property type="term" value="F:peptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030162">
        <property type="term" value="P:regulation of proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046578">
        <property type="term" value="P:regulation of Ras protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00866">
        <property type="entry name" value="PEBP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.280.10">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008914">
        <property type="entry name" value="PEBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036610">
        <property type="entry name" value="PEBP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035810">
        <property type="entry name" value="PEBP_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362">
        <property type="entry name" value="PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11362:SF78">
        <property type="entry name" value="PROTEASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01161">
        <property type="entry name" value="PBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49777">
        <property type="entry name" value="PEBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW58403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="18774" checksum="A36D17517DBC0E71" modified="2019-01-16" version="1">MADSKKSVEAAMALSQDESTRLGLAFGTQKITPGQHVPKGDAQSAPELSFNGATGTYIVISIDLDAPFPAFSVLGPILHWNQPGLKPQPAADGTTHLVADNVPFIADYSGPGPPPPSRPHRYVFLLYEQPEGFDVAGFAPPGGAKVRLGKRVRYDLKAFEVAAKLGPVVACNYFVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q9E3</accession>
    <name>A0A3D8Q9E3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_12349</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q9E3"/>
    <dbReference type="OrthoDB" id="3557394at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="3"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW58419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="548" mass="60112" checksum="47875961AE9DD29A" modified="2019-01-16" version="1">MIMGDIYKSARQVVVWLGEAADNSHLVFAHLKDDTRKSAFPNYPTPPAPQRRAWTALISRPWFFRTWVIQEVALNNLKATIICGEDSAPWMDLSSGSARDISGGADGLSSISSSPGNDPDHPLAGINVDCHVWRLRMLRAGSDPVDVLRYSRVCQSSEAKDRIYGILALFEPGFIPVDYHLPAEQIFGQFTEAIIQRMGDLHVLTCLGVGPHADSLPSWVPDFMNTKAVGTLPQHRWNPPYRPEGPVSCYTLRAADGTTQSSVASNDFPHKFLPGLAFPAGGALAVRGKLVDTIRTLGPVLPADTAWAPGTVAFFRVIRAWKSLAAALVPGWEKGKHPPPMFAHELPFITRAFAATLAASHRNELYSIDVGFTEWYRHCGTGVLEAEDPGMFLRKREFYLWWLSGARLDDDACGGEREAHGEGTRSGDAALLNELPTRSSSSSSSSSPPPPPPQPLSYELSRFAEQMEIACYGRCFFTTEGGSMGLAGPRARVGDRIAFIPGGDQPFVLRPRDGGTGWTMANDCYLYGLDPYALFEDDEHVVEEFVIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QAZ7</accession>
    <name>A0A3D8QAZ7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_11949</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QAZ7"/>
    <dbReference type="OrthoDB" id="2585655at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF20">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="384"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="410"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="449"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="480"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW59025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="520" mass="56086" checksum="B0F1A89B91DB853B" modified="2019-01-16" version="1">MAFGILESSNNARPTGTTLLEDLHANGGQVEAEVILVPQPSSSPDDPLNMSRLRKELLFATIVFGACVTGVVGPLLVPGFSIIAADFNVTLTQVTLLNGVLLMGLGISSYLCSCFAQIYGRRLVYLFTTVLCIAACCWGAAAKSYHSLLAARFFQGLGMGGFFALAGTASISDVFFVHERGFRVGIWNFAVIWSFWILALTFGVVLVMTVCLFSETTFERETTTEEPIRTLHHTEVITVPYTPGEKETASDADNETADNAVGQLINPAKFNLSRDLGLGSLKIHGQMRIFEMCVTPIMLLRHPGVIWAAAMWSVTFTWVIIQGAVADQIFEAPPYNMSAIQVGNLVGVAPLIGSALGTLVSGPLSDWLALFMAKRNSGIYEPEFRLFLVIPALISIIIGAFGLASGIQKGASAIVCGVFLAIINFSVGVGCTGIVCYSNDVFKQNPGGVFGVVMLIKSVFAFGLTFMFNDYYTAHGPLKFFSLFGGLTAGVMLTTIPIYIYGKKIRDWSDRKGLLEATAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QB56</accession>
    <name>A0A3D8QB56_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">3-hydroxyphenylacetate 6-hydroxylase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_11997</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="7">Aromatic compound metabolism; phenylacetate degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QB56"/>
    <dbReference type="OrthoDB" id="1055148at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000072">
        <property type="entry name" value="3-hydroxyphenylacetate 6 hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF9">
        <property type="entry name" value="P450, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0349">Heme</keyword>
    <keyword evidence="5 8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="8">
        <location>
            <position position="446"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00060591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW59073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="519" mass="58351" checksum="44F5C4E8B14808F1" modified="2019-01-16" version="1">MTIPGITHVFQGRLLDGIIAQFALGLVLIPAVYIVYNEVVRRKARIPALKGPSGLPLIGNLHQIRTNAAEQYRRWAQSYGGVYQIQLGNIPIVVVNTAAAAKTIFGQNAQSMSSRPEFYTFHKVLSDTAGTTIGTSPYSDSLKRRRKGAASALNRPSVQTYLSHLDVETRDFCKELLTYGQAGTVAVDPMPMIQRLSLSLALTLNWGVRMDSQDDQLFHEITHVEDEVSRFRSTTGNLQDYIPLLRLNPFNVGSAKAREMRDRRDVYLKALNQGLDERIVNGTYKPCIQANVIMDKENKLSHEELTSISLTMLSGGLDTITTLVAWSIAMLVQRPDIQETALAAIQEYFGTEVPLCDPLDDQKCTYIVALVRECLRYYTVLRLALPRASVKDITYDGIVIPKGTVVFLNAWAYSEVWEDPETFRPERWIEQPDAPMFTYGLGYRMCAGSLLANRELYLIFIRLINSFELVKCDEIDHHPLTGNSDPTSLVAMPHRYLAKFVPRNENALRESIQNFVAVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QCV3</accession>
    <name>A0A3D8QCV3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_12168</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QCV3"/>
    <dbReference type="OrthoDB" id="3172332at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF4">
        <property type="entry name" value="HYPOTHETICAL CONSERVED PROTEIN (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW59244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="387" mass="44324" checksum="026B8E18872C4A15" modified="2019-01-16" version="1">MSLTPIEREAAANEHHQNALKQYAKAVKHMASHASEKKQDLRTMLLTCLLILAFESWTGNMDFAVNQVHTGIRLIQEWKENYKNDEDKFTRLSPAPYIVEDDLIQIFCRLAVQHSFFADGHSPELHAVLGMEGPRFTKSMPGTFSDIFEAGKFYNGIIRRGVYLITTHSAYLGPDVREDSEIWRWALKEQEEIQADVWRFNKAFEPVLQRVGDGPEKHYALFIQLSMAIGYIGLSTHLSPDELIHDQYNPVYQRVVYLAKAVMQEIPTRNKARPSNFCFDTRVIVPLWVVGLKCREPSIRRQAINMLLSSPRREGIWDSIFAGRVLQWAMEIEEEFLEDGKVPGWARLAGVKWSGAELGGKRAELVCLQKVSADSGKMVRRTKTITW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QEA8</accession>
    <name>A0A3D8QEA8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AA1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_11647</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QEA8"/>
    <dbReference type="OrthoDB" id="5395704at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017637396" description="AA1-like domain-containing protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW60041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="210" mass="23246" checksum="D1A1D4EC5D821A3B" modified="2019-01-16" version="1">MRFVHFLSLVLSFTCIATALLRGSDLETVETRVARARLARYVPESISDKASRGSIRRATLAAQAHVKNFAVSDIYTTDFFSSQTAWNRTITFLFADNNSNTSTICTKSWTQSNTTNNYPTSYVLCDFTADNSDVFYFKFDTMTSLGNFTLELAHEFSDPVNYPPPYDVVEYFSAPTKFTLPCDAKTTTSGVFTNCVTAGPTTVIVSGIAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QEI2</accession>
    <name>A0A3D8QEI2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome production factor 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ribosome biogenesis protein RPF2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_11841</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
            <location evidence="1 4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RPF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QEI2"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039770">
        <property type="entry name" value="Rpf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728">
        <property type="entry name" value="BRIX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728:SF0">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="28"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="285"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="300"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW60235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="325" mass="36932" checksum="5484C842DC92AC8E" modified="2019-01-16" version="1">MLRQIKPRNARSKRALDKKAPKAIENPKTALFLRGTSCSQITQNALTDLYQLRIPLAKKFTKKNEIHPFEDPSSLEFFSEKNDAGILVFGSSNKKRPHAITLARCFGHKILDMLELNLDADTFRTLAQFKNKKCAVGLKPMLVFSGTPFESPVSDEYTLAKSFFIDFFKGEPADKVDVEGLQYIVSVSAQDIVDGAESKPQIHLRVYLIKTKKSGQKLPRVEVEEMGPRMDFRVGRVREADESVLKEAMRRARTSAERPKKNISTDIVGDKIGRIHLGKQDLSELQTRKMKGLKRSRDVVDDDFDDEMEDEVVSEEEGKKKSRRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QER5</accession>
    <name>A0A3D8QER5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_11756</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the bZIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QER5"/>
    <dbReference type="OrthoDB" id="644067at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47416:SF8">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR E-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47416">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00170">
        <property type="entry name" value="bZIP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00338">
        <property type="entry name" value="BRLZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="8">
        <location>
            <begin position="252"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW60150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="627" mass="69359" checksum="7C7F43270BC0A7AD" modified="2019-01-16" version="1">MAAFPMQHFYRPSPLTVDTHHTHNYFEEDEGSILDEHILDNSGLDSGLEMSPPMNGSRRESFAVSSALFSPKTDEWQHVEMQPMASNNPFVEHNNNNPFMRIDSTQSSAYGHQGNGWGMNHGSGISTPMQVHDGLSQEFEVNAPVFQQRPVQTPFSNSGNQQLPLFSSSNTSNGSMPTSPQKEWSVAEAMDHRSIPKRMRPHSPTLRSHPDMSRRGDGIRKKNARFDIPAERNLLNIDQLIAQSNDEQEIKELKQQKRLLRNRQAALDSRQRKKQHTERLEDEKKHYTALINDLEEDLAEAKLALDEWARKEQQYQQYIENMQLEKEEMVRAHTLETGDLRKKVSVLTEHMSKLESSTMSTVPSSTGFATDFADIDSLTMDGAWDNISFLNDYPVEAEVKVENAVVPAKKEATLLSEPEKPAAQGLLLMLLLFGAFVASKGSSASSPSIPTMSDDVRAASATLLQDIFKDAGVPQTASGVSEAMAPLPSGSTWKNMASNTVNAMAGNKMVGVSSSTLGDLADSLAQPTEQQRNEQVFSLSAAQYDGLTSHDFLQHTPPPSTSKGRRNLGESLAAMRSDSEKSVAEVYTRSLLWDQVPSEVVRNFAKMVSECNSQNKQAESGGKTSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QFJ8</accession>
    <name>A0A3D8QFJ8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_11800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QFJ8"/>
    <dbReference type="OrthoDB" id="407832at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF2">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW60194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="472" mass="52881" checksum="28ED230601E36829" modified="2019-01-16" version="1">MPRHAAANSWYEVIISGAGNDIKASPTYRSDADKILTTGDGLRPICRNCIKANRNCLGADGGLKFVIHTNDQSLVQQNRNPQNQQPSHSPPPILAGLENKPQGEQELDALVAANPRAALANLEIAEIFRHYIDVLAPWYDLCDSEHLFGNTVPLRALENSTLFRAIIAFSGYHRSKISGYGPVIGLAFHAACVKDLLKVVDNFQLGLRGDYLAATCLLRSYEILIGDSRKQQQHLLGAYLFSSNEPLDMSHSGLAQAGAWNYLREEITVALECNRPVRLGFEFHFDPSKSYTDSMRANIMSHLLARTINHCFHEPEDGLVNEARQQSWQDLQREVSAWKANLPASFEPFSKAVKEENPFPSLWLVHPWHVAAQQYCSIAEILLAIYDPFSPIDREFVLEQTLNVCGLAYTNDNVAARVNVFGPLAYCGKYLQTTRHRQGLMSMLREFALPTAWPVGCIIEDLERCWSLHHEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QHW8</accession>
    <name>A0A3D8QHW8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aldehyde dehydrogenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_11261</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QHW8"/>
    <dbReference type="OrthoDB" id="5322683at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003842">
        <property type="term" value="F:L-glutamate gamma-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050485">
        <property type="entry name" value="Proline_metab_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 1, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42862:SF1">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE DEHYDROGENASE 2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="4">
        <location>
            <begin position="34"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="137"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="148"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW61369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="161" mass="17599" checksum="9B6D4C6060860B14" modified="2019-01-16" version="1">MAGIQEEPFGQDGNDPGRKPRDPPELRQSYHSRAGLLVGKADKEVGYFEHPTVYQVSDPRHEIMQTEFFGPMVSVYVYPDAQWEKIPQLVDSTSKYALTGSIFATDPAAIRHAYDGLKHSAGNFYVNTKSTGSVVGQQPFGGSQGSGTNDKVGSVNTLSRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QID6</accession>
    <name>A0A3D8QID6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_11488</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QID6"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06179">
        <property type="entry name" value="MFS_TRI12_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053791">
        <property type="entry name" value="MFS_Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF109">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="255"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="326"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="393"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="420"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="542"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="60"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="579"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="585"/>
            <end position="603"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW61596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="603" mass="64454" checksum="0100E3FB1EF03B40" modified="2019-01-16" version="1">MLESQSKVEEDTIRGDELSQQSNVEARHVAIHTDTYDIDEDALGTNLPKHYYLSPGFLGTVAALCLGNISNYLGWIMPSNSLTLIDEAIGPSPNITWVALAYTLGLSVGFLLVGRLSDIFGRRWFFILGNVFALIGAIVSGTANHVESIIGGNLLGGLAGAVQISFTVAISELVPNKHRPLWISAIFFSSFEIACFGPVIAQTLVTNTAAGWRWSFYLDMIVAGLAAVLFYFFYHPPTFRLLHKNRSRMEQLQRMDFVGVVLFSGGLAVFLIGLSWGSGTYAWNSSHVIATIVVGAVGLVIFVLYDSFVHRGDPLMPLHLFRSRGYLAMVITAMVGSCVYYSMNVLWPQQVAYLFPGTTTHEGWLACVVGSATLIGQIVGGILCRFIPKSRYILIASCLSLTAFAASMVSIAPGQETKGIVLMFMACLSVGIIETCSLALAPLACASEDLGAALGALGSIRSAGASVATAIYSTILTNKLNTFVPKKVTPAALNAGLPQSSLSALYTNLTAGTLTKVAGINSDIIAAVVEADAQAAAEAFKYVWYAVIAFACVATIAACLTIDYGEYLTEDVARKMHSATAGMPSDKEGNREAEGLHIENRDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QMY1</accession>
    <name>A0A3D8QMY1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GH18 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_11116</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QMY1"/>
    <dbReference type="OrthoDB" id="6020543at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004568">
        <property type="term" value="F:chitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001223">
        <property type="entry name" value="Glyco_hydro18_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050542">
        <property type="entry name" value="Glycosyl_Hydrlase18_Chitinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45708:SF49">
        <property type="entry name" value="ENDOCHITINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00704">
        <property type="entry name" value="Glyco_hydro_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51910">
        <property type="entry name" value="GH18_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH18" evidence="4">
        <location>
            <begin position="419"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="206"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW62814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="723" mass="73638" checksum="49CFCED75B8281F7" modified="2019-01-16" version="1">MANGIGSEHFELRNDGMIDLPRDVTSLKTVLQQIQHLETEIQSLMARLHPRDVSGSDPVNNHRTLTANSDIWAAVVGPGGTISEQEETQAALSGASSSVSTARSAPAQGNAAATSGAIFLPVAISQVASSAPSKSPAAIIPIAESQVLPLGAVMPVASQQPAAISPVAPAPAPSTSAAPNQPAASSIIVSLSTPAVVGNTASTSQVASPASSSLGSGNSQPAVPAAPAPVSTAAASSQAASSASFTPVWVNGDPATSAAVVDNSPTSGVASPAGSLIVLPFLPRATECTATSSSYDGAVNTTSTRTVTSKVTSRAYVTVIVTAQADLDESAATEIVNSDSAGAIQIQASATTASSQRDSSGGVFLENVVNANSQTTQAAQPMAYNIGLPSESTLSAVATSPSSEPSGSSNYVFNAQSSENIAVYFGQTGATSLDSLSELCADPSIDIVILAFVIAQLDGGIYPQVNFGSACGGQTAAMKSEAPGLLSCPLLAAEIEKCQSVYNKKVLLSIGGATSQISFTTPDEAIIFASVLWELFGPVGKTSVNLRPFGNVSVDGFDIDNEDNLPNFYDKFASTLRSHYSSTSSKTYYLSSAPQCPYPDASNPLAMLLLCDFVWVQFYNNAGCEIGSSDFSTSVEGWSAHLQSSTLNPPPRLYIGAPSFPAAGSTAYSAIGSAGGMENIAKEVKSIGVSNLGGIMFWDGSEGLDNVQNGKTIIDYAKIGLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QRA4</accession>
    <name>A0A3D8QRA4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">THO complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_10526</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the THOC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="29024at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040007">
        <property type="entry name" value="Tho2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021418">
        <property type="entry name" value="THO_THOC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021726">
        <property type="entry name" value="THO_THOC2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032302">
        <property type="entry name" value="THOC2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597">
        <property type="entry name" value="THO2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11262">
        <property type="entry name" value="Tho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11732">
        <property type="entry name" value="Thoc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16134">
        <property type="entry name" value="THOC2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THO complex subunit 2 N-terminal" evidence="8">
        <location>
            <begin position="130"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 N-terminal" evidence="7">
        <location>
            <begin position="855"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 C-terminal" evidence="6">
        <location>
            <begin position="1222"/>
            <end position="1534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="558"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1118"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1552"/>
            <end position="1604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1653"/>
            <end position="2435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="48"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="60"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="569"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1118"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1154"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1559"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1586"/>
            <end position="1598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1653"/>
            <end position="1664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1665"/>
            <end position="1688"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1712"/>
            <end position="1779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1890"/>
            <end position="1906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1928"/>
            <end position="1947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2044"/>
            <end position="2055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2056"/>
            <end position="2073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2111"/>
            <end position="2129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2148"/>
            <end position="2163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2181"/>
            <end position="2199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="2211"/>
            <end position="2221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="2231"/>
            <end position="2240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2244"/>
            <end position="2258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2267"/>
            <end position="2277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="2278"/>
            <end position="2291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2295"/>
            <end position="2342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2352"/>
            <end position="2376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="2386"/>
            <end position="2428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF11262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW64024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="2435" mass="269169" checksum="B90B5FC88176E52A" modified="2019-01-16" version="1">MAPGGKRKRNDRTSVDSGESRPSPHRPGNTNLAQHDRDSDRDGRRPGRGGGGGASRGGGRRNDGRRDSNHSLSQANLKVPTRATPTPGPMSPSLQQPSATQTPTSASATFTEVPSPLPRSDPAPFDYAIVTEERVSAWDKGGKREVIEIGTQARKSEDEMELSCVFQELLRAVLDRRIDSTEGGNCVKEILGPDTAPTEETTSMDLQNLFIDTLSMLLDAEDGPFNIDLRAFIAATAISPLVLRQKLDGQVLQSLGLTRDTFIRVGIRQATNLLYKQANYNLLREETEGYAKLVTELFSISGSEPPSAEVVEDAFEKIKGLIGTFDLDVGRVLDITLDVFAAVLIKHFRFFIKLLRVSSWWPRNGETDSAAAARCAGLPKWAMPTSQGWMSTEEDDDLSKRQRLERDTLFWERARDVGIDAFFELGGRQMVDPETKKQILNGTGGDAELDADRQWIEGTGTYPPSGNRIAAQLLGFKLRFYASPARDKDDILPANLIYLTALLIKIGFISLRDLYPHLWPLDDVMPAVRDARMKELQEKEKANRPGGGASNALTMAGALADDMPPPSTRTRETAAPKPDAVKVDEDDTEKLDEPTDQKVQLLVCLLTIGALPEALFILGRFPWLPEAYPELIELINRILSHSIKDVYEKCRPTVSDTSGIVTKNVADYDQSGVPKGQVRTSRLPTRKQLRWPFPDKFDTNESNCYRFYWDEWADNIPVCQDVDDVFTLCGTLLNYSGVGIGRDASLLSKLARIGTKSLAEDHSQQNLARWEDLLKRLLVPALSLTTSNTSVANEIYDMLRFYPVSVRYNIYAEWFEGQISRLPAMKSAFARTRLETLATMKRISMTNLTPMARSLAKTAFASPGIVFSVALSQIEAYTNLTEVVVECAKYFTDLGYDVLVWSLMSSLGGKDRNRNNAEFALLPSRWLLALSRFSGKVFKRYSIMNLSPIIQYVNDQLFRGNSTDLVILKELIAQMAGVVPDTDFTDPQLAAMTGGELLRKQTLINLQDKRYESTKTAKRLMKALTETKLAGPLLLSIAQHRQAAIYAISDDEAHIKLLSTMIDDAQMMLFQYLDLLRSNLLADDFDKQVPGIPELISEFGLDPSLAFMIGRASFANKLTKSSPPTNNGAAKPLSGTTDDVSKLDPDGDESMSVDVDKEAGKMDADSANDLTSNDDLQMVDANDAGFMQASNGSDPASPIDTTKDVLEPVVNTVKEILPENSWYFVSPEFYVIFWLSTLGDLSIPSTSYENEIARLVKEQGEIQKDRSDMSRAGMLRKEEARNALGTTKDNLLAEYGRQVGLYKQNKARLLKSKVSWFSNSANVKPDAISAAFLELCLIPRLLLSPSDTDYCFRMIRFLHDNNTPNFRTLSVYIQIFKASRLRSLIFTCTVREAENLGRFLRSILTDLARWHGDQAIFEKEAWGTNKDLSGFAKAVDEDFKPKGLIEFESGKTGFRSILLSWHKNLNTALRDCLEGTEWMHIRNAISVLKQVCPVFPAVDFMGNNFIKQLEVVGKREKDVREDLSLTGNAVLVQLKKRSKSWIMVQAFASNLNEPGKMNGTAQKSTLGQESTAASRLKPTAPEFKPQSRSSSMGVSTPKPQEVEDGEVDDAKMAQNGSARAITNAAVSTDGLSTTQGSSQTPVLSAAELRREHLSRKDQLHRDNSSKPSSPATSHGGTPRSDTSRNASGTALPERTNANLPSRPEVAFPGRQMLDRHPSRHGDRRDTRDARLPETSRGDRGNERLRDHGSSDRRVIDLPSRDYGRSGDRNAGLERDRPSRITEPPPRWTGPHESLDRATTNGVRLPDNSGRLSRESDMPPPRPSATASDRGPSINPERLSLVNPDRQELINPERAALISGEDIHVGSARLGKDEHNSRPTSRPQSPRRHPSTRDDARRDDRQSRHVASEQYGSARNRGDESHPPPAGPRNDRQPERPSERGATDRSRDPSAFQPTPTNRPIDHSHGRLNANPRQQPDPNFGRLNPAPASDIPSGPRDRNSNARGNRMVSAPQPRRDVGPTTEVPRIPSPERHPPTGPAAGRNPRHSASGQFDTLSNASASQPTTPITSTAAAPSVHPDRLRQLEVQATTVQSPATPAPPPGVHPDRLKAFGNDSSSNSPPVNQLHVNKSRPSAPPIRTMTPSAPPSGPRATQQSPISNSPNVLTAPTGPASASERAARGGQRQLNNIQNMLQQAGQQNVPNDRIGSIRGRSNRMNSMSQPATPVSGPSTPQGIPPPPPGLPPLRSESRNLDMINSDRADLITGQGSMSEERNHSDRDRNGRHRSGHQSRRNSKSPDYNRESKRGGTDEDRSRREHRDRSGMERAPGRERHSNRESTDGRDLMAGREVGASGKEGGRDRDRESSRRHGGERDRGREMPDAQWGQGNNERNDKSIGRSRDARGEERRDSRGPREDGGRKRHSEGADIEGRGREKRPRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QU58</accession>
    <name>A0A3D8QU58_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_09999</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QU58"/>
    <dbReference type="OrthoDB" id="3014581at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF90">
        <property type="entry name" value="CENTROMERE DNA-BINDING PROTEIN COMPLEX CBF3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="125"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW65307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="642" mass="72987" checksum="04D1F52C9AB2CF43" modified="2019-01-16" version="1">MALLRPKAIEELRTRVKRLEDMLAVKSISKPLVRQDNAASSDTSLGEDRDDAELSKAVFRLETDAFDYKPSPEMAVTHYMTPNAQTPDSLGVSFQALISPSSAISLDLPFIVSTLPNRSQGHILINYYADHVNWIYHILHMPTIRRMNDVIYDALDQNQLPQHRHLALVSAVFGLSAYFGYSSPTFLFKGPDAKEYSYRWTSLAQAALSAANFINIPSLETIQAALLLAQHVLPNVGAIATFRTFAATAMHSARSLMIHQLDSPTNQRRRQNNPNVDWVDIELKRRLWWHIASTDWMLSFMSGPQCGSYMIHPKQMNVNYPANVDDEDIGSSPDYNKPMSVATEMTYFIFRNKTSEIFRDIVDAASDAGCELEDLPYDLVLEFDKRLHFLIHDAPPFFKFDTKSRMQSQDADRRPFISYQRNMGHFGLHTRLSRLHRPYLARGAHDPRYSYSRIVCLRSSRTVIELGSQMMAAGHNSEPLRVSSVWTVVHHIFVSTVILVMDFSYNRSDPQAAKRREEILDCFRLLERSQEDSTIARQGLKQLREFLNNRKWKKDHAAEPSSPMATNVRVAQSVPSVDNSALYQPAQQSLVSTAPAEDPLAGYDFSNMDNSLLEYLNFDANLDSSEWETLFQNVEGSSNPLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QU71</accession>
    <name>A0A3D8QU71_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cupin type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_09923</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="3">Binds 2 manganese ions per subunit.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QU71"/>
    <dbReference type="OrthoDB" id="10263073at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033609">
        <property type="term" value="P:oxalate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20305">
        <property type="entry name" value="cupin_OxDC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20304">
        <property type="entry name" value="cupin_OxDC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017774">
        <property type="entry name" value="Bicupin_oxalate_deCO2ase/Oxase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006045">
        <property type="entry name" value="Cupin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051610">
        <property type="entry name" value="GPI/OXD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03404">
        <property type="entry name" value="bicupin_oxalic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848">
        <property type="entry name" value="OXALATE-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35848:SF9">
        <property type="entry name" value="SLL1358 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00190">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00835">
        <property type="entry name" value="Cupin_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1 3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017613182" description="Cupin type-1 domain-containing protein" evidence="5">
        <location>
            <begin position="22"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="6">
        <location>
            <begin position="124"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Cupin type-1" evidence="6">
        <location>
            <begin position="305"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="79"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="2">
        <location>
            <position position="411"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="353"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617774-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW65231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="463" mass="49988" checksum="91BE9B41A8421A62" modified="2019-01-16" version="1">MALRIFTVFILAFSSLDRGLAAPAGTKVARQDSSGSLLGYNPANGVINQDTDKIDYELAAGQTDAATVGAYLDFNNVKNPQPIRGTKGGTDPGPRTEEYDKLNPDKLAPPGTDHGSVSNAEWPLGLSHMKLGLGGAGWSRQQNVDNIPAATEMAGVDMRLEPGAYRELHWHKAAEWAFVMNGSVRVQAVDENGRTFVDDLSAGDVWFFPAGIPHSLQGLEGGVEFLLIFDDGSFSEDNTFLASEVFAHNPKEVLSKNFALPLSAWDNIPPGELFIFPGTAAPKDIEAQNITGSAGLLPVEDSYTYHFSKAPNTHETEGGTVKVIDPTTFPIASSFSAALVTIHPGAIREIHWHTSSDEWNFFLAGNARIGIYAAQGNARTFDYHAGDCGYIPKSMTHYVENIGTDDVTFIEVLQADHFSDISVGQWVGLTPAQIVQDTLNLSDETVAAFKKEKQYIVQGAVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUF6</accession>
    <name>A0A3D8QUF6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mediator of RNA polymerase II transcription subunit 22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_10097</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Mediator complex subunit 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUF6"/>
    <dbReference type="OrthoDB" id="203279at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.280.160">
        <property type="entry name" value="Mediator of RNA polymerase II transcription subunit 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009332">
        <property type="entry name" value="Med22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12434">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12434:SF6">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06179">
        <property type="entry name" value="Med22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW65405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="149" mass="15918" checksum="5F83F4A751C27920" modified="2019-01-16" version="1">MSPAMLAQLSGNGRLTTDPNASFATSSFSFADDDKTLTQLLLDREERAVAALLTRFKNLVTLAATPAGDGATKEVAASQSFQMEVETNALIGAAEDLLKLTRELKEMWLFGPLRDIGEGESEGTIDEDAKKVGEIVDKLLEKSAQAPAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUK6</accession>
    <name>A0A3D8QUK6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_10181</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUK6"/>
    <dbReference type="OrthoDB" id="5428890at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW65489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="500" mass="57420" checksum="513992657BA9BE40" modified="2019-01-16" version="1">MEPMELQQFAERYDLESQMPRPRQRNFMPQGSIWHDQLCDGTSETSTRPSSTYFPKLPNIFWSQGRAATNTSTSTTLADFCLTTGQEEFINFVAGDSVQCQSQPIMKKYGDWYIRYLNSKVRSSWEVLYLPILEGVANGDSKDDVSSSDLSVAFKLHVAILAELRKDKVGLVQIVDALYNKDLLHDDKEDKDGERLKAIQLVFTAIGWISSLYTPHNPADTPTNCLQLQPVVESSPNVQSSRLSQNHTSKVFRSICEKIEDAGDEKFYSLIKKFSPEIIPKYGRTSQLGRGSPLGTPRMTLQPLEDAIEQRLVCFATLKSLGNIAIKWVDNTRQHLVFDPRGKVLYLFGKPSICLIHAVKNTSVLAKMFENSAGNNFMFRDPDQHDDAKLFYREILLSYRLLFGQNYKSYNGFTIPKETEMQDPLLKVLCSQSYEDDEPSEIYFLIDANHPARTYCARNDFPFLGERLLKIQGHVRDLRPHSIREIWNDTRDLPYWWAFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QV37</accession>
    <name>A0A3D8QV37_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Alcohol dehydrogenase-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_10321</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QV37"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="14"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW65629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="332" mass="36268" checksum="8ABF6D2BF59A32E0" modified="2019-01-16" version="1">MGYEFTVYKGGKEGLIKSTTHKDALKDDEVYLQVTHSGICGTDCHYRSAEMALGHEGVGVVKEIGPGVKSLKIGDRVGWGFEHGSCGHCHECLTGRETYCSERHIYGSSNLDQGSLASHAVWHESFLFLVPENLKSEEAAPLMCGGATVFNALNAHSVKAYHRVGILGIGGLGHLAIQFAAKMGCEVVVFSTTASKKAEALQFGAREFYTVSELEKAEAIRPIDHLLVTTNTLPNWDIYLPLMAKGGTIYPLTVSFEKLQLPALALNMAGISVQGSFIAARHLHRKMLDFAAFHDIKPVVQKWPMTVQGIDEAFKRLDDNTMRYRGVVVAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QXX3</accession>
    <name>A0A3D8QXX3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Peroxidase</fullName>
            <ecNumber evidence="12">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BP5796_09364</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 12">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="9 12">Binds 2 calcium ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
        <text evidence="9">Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the peroxidase family. Ligninase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="12"/>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QXX3"/>
    <dbReference type="OrthoDB" id="2113341at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000021">
        <property type="entry name" value="Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001621">
        <property type="entry name" value="Ligninase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF66">
        <property type="entry name" value="CATALASE-PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00462">
        <property type="entry name" value="LIGNINASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3 9" id="KW-0349">Heme</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="4 9 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 12" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017496668" description="Peroxidase" evidence="12">
        <location>
            <begin position="19"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="14">
        <location>
            <begin position="54"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="280"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="304"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="77"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="9">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="207"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="59"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="11">
        <location>
            <begin position="50"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR601621-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDW66615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="414" mass="41843" checksum="772D068AF44BBB69" modified="2019-01-16" version="1">MRIPSTIAVALATTFAEASVMSRAGGACPAVWTQVSQDLTKMFVQADKQCNDDARAAIRAVFHDCATWAKAQGNTGGCDGSLFLSAEENARTGNRGLQSISTKLTDLAQQRGVGVADMIAFAGAHATVSCPLGPTVKTMIGRTDSSNAAPDEGLLPGNASLSADTIITLFSDKGFSAPDVAALVGAHSSSKQFFVDPSKAGAAQDRTPGIWDVDFYNDTTNKPPGVFVFQSDMALSQDPRSGPAFKSFIGQQAKWNQAFADTFSRMMLLGVPTDNLVDCTAALPPPTDSFPGANEPVGAPNSPAAPGKPTAAPGKPTSPPAKTTSAKAKSTSGPAKPKSDPPNAPSGTAGGPGFGGPNGPYDPNGPYGPGGPDGPNGPGGFGGPGGPGGSGFPTGCWAGQQNKPTSFPTARPSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QY18</accession>
    <name>A0A3D8QY18_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09462</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QY18"/>
    <dbReference type="OrthoDB" id="610608at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003885">
        <property type="term" value="F:D-arabinono-1,4-lactone oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.10">
        <property type="entry name" value="Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016167">
        <property type="entry name" value="FAD-bd_PCMH_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010031">
        <property type="entry name" value="FAD_lactone_oxidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762:SF1">
        <property type="entry name" value="D-ARABINONO-1,4-LACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43762">
        <property type="entry name" value="L-GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="1">
        <location>
            <begin position="206"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW66713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="757" mass="85059" checksum="884863417FD07872" modified="2019-01-16" version="1">MSSQSTSIPPINLPPPPPGHLNGHYILGEILDHLSFYESTFDRIKFDELYHLLNEVRNHNVDRESTYRSFLRAFERTTTYQNSFKELDPETREMIGKWLGGENAGVLTKEDFKLPLSPAARKHFGHLQKVREMMRTLREVKQNGISGLLHDALSKTEPEKLSTTESGDIARLEDAMKDLPQIWADTESKIHVECYPSQVFHNWGLTVQNTPRWTFIPTTVLGIQNIVKFAAAQNLRVRCAGFRHSWSSTFSADGEILISLLNLEIANEVPSPLAIASDHVEALQDAGNELKTIEMVPGSESLDGKTALCRVGVAVTNEQFRRWAVRNNKWALPVDVILVEVTVGGVNGPICHGAGIGHKTIADYVRAVEYIDANGTPQIISDAKELKAAAGCFGLLGVVTHITFALDKMSYALLKPAKIDVGLAIPPPRGEDIPLALQKTWTKAQIAAAQDDFVSRASNDYYSEWFWFTFQKQAWVNSWSTTSDGEGAVEYPCRGETFLQWLENWFGGVLTSHPFFQAIPGWWQAQLLATAGMVALPPTSFAARGGSSGSGSVQDAVTKTPLPNGLHFRRGIQNMRVRDMEFQIPIPAQADGKPDLRIVQRAWWDVIQLVYSDAETPMRLTMEMRIMNGSEVIMAPQRGNQWTCSIEVLTIPDSVTDGEWSGFCVQVKDLWLRYEDEGLVPRGSVRPHWAKEWESLTFAGERGESLTARQYLKTVAYKDAILEFKDTLTKIGHKQEWELKDLQHRFSNELWDEMIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYL0</accession>
    <name>A0A3D8QYL0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_09662</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYL0"/>
    <dbReference type="OrthoDB" id="5819582at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF125">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="440"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="57"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW66913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="483" mass="56132" checksum="F59486076619ED20" modified="2019-01-16" version="1">MSARHETILESGEWDSGKQDGILSASKAHNAAQWCMETIRPSVLTRVGPKRQIRRTAYLDGLRGFAAFLVYWQHHQLWPRPGGDAIFENAFGYQNKYYFACLPIIRTFFTGGHFAVAVFFIISGYVLSTKPLTLIHSGEYSKLGDNLASALFRRWLRLHLPVIVVSFLYMTTWHAFGIWTVAPEHKLTYSEEVWNFYLEFKNFSFAFRQGGEAWFTYNFPTWSIPVEFRGSIIVYTALLAFSRCTKNARLLGQLVLIFYFMYIVDGWYGAMFITGMLLCELDILARTNELPRFIARLEPHKTTIFYSLFVISAFLSGVPSHTNNIEVLRESPGWYYLSFLKSQAVWDLKWFYLFWAALFLVVSIPRIGWLRAFFENRFNQYLGRISFALYLVHGPVLWTVGDRLYTAAGWHRDSHLTFLPGWVDIFLLSKEGPLGFEMSFLLPHLVILPLTFWLAEVATKLIDEPSVRFSQWLYERILPQQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYW8</accession>
    <name>A0A3D8QYW8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acriflavine sensitivity control protein acr-2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_09716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYW8"/>
    <dbReference type="OrthoDB" id="5380854at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF51">
        <property type="entry name" value="ACRIFLAVINE SENSITIVITY CONTROL PROTEIN ACR-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW66967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="458" mass="51159" checksum="95CB861F5A95BC52" modified="2019-01-16" version="1">MMGLSYGAVAKSTQKKQQGASGEDACCRLVMSRSLVDPLFQDLTSSHRYYLSYFASSLFKDLVIYDTPNYNPLRDLIPMSGEHAVLRYIMIASSALHISNVSRKANSSLTKTPTYSSAMISSQSMEHASPTSYRDGLIAKQRALQLLSTALNDMRTELVDIALATVLLFIECDLLDSGNNDWRFHINGARTIIGTLGQHSKLGDVKMSSLRRCLISNCLVYDIFGSVSTCPKLLETPQSIRFDITPLLRFAEANNYLSCPAVLLQTLLAASQISRNLPNELASNETFKVAKERTEALLWTTQSFDPLSWATELQKISPQYDLDSRIHIASAHKAAVCIYISRILLSFSPNSESYENFEPLVSDIILHLSFISQEDPLYKSITWPTFVAGAETRDPERQAWAMTRLHQLWGILLWGYTRNIMGVLAGVWEKRVTPVGPGSSALDWIQDLMTLEFDCLIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QZ43</accession>
    <name>A0A3D8QZ43_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">AA9 family lytic polysaccharide monooxygenase</fullName>
            <ecNumber evidence="16">1.14.99.56</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Endo-beta-1,4-glucanase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">Glycosyl hydrolase 61 family protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BP5796_09798</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Lytic polysaccharide monooxygenase (LMPO) that depolymerizes crystalline and amorphous polysaccharides via the oxidation of scissile alpha- or beta-(1-4)-glycosidic bonds, yielding C1 and/or C4 oxidation products. Catalysis by LPMOs requires the reduction of the active-site copper from Cu(II) to Cu(I) by a reducing agent and H(2)O(2) or O(2) as a cosubstrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 16">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="16">Has a modular structure: an endo-beta-1,4-glucanase catalytic module at the N-terminus, a linker rich in serines and threonines, and a C-terminal carbohydrate-binding module (CBM).</text>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="16"/>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW67049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QZ43"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008810">
        <property type="term" value="F:cellulase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030248">
        <property type="term" value="F:cellulose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF36">
        <property type="entry name" value="ENDO-BETA-1,4-GLUCANASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 16" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="8" id="KW-0186">Copper</keyword>
    <keyword evidence="10 16" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="11" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13 16" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0964">Secreted</keyword>
    <keyword evidence="5 17" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017655448" description="AA9 family lytic polysaccharide monooxygenase" evidence="17">
        <location>
            <begin position="22"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="18">
        <location>
            <begin position="22"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU368122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RDW67049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="352" mass="35119" checksum="3FF5A170240DFE3E" modified="2019-01-16" version="1">MYSFTSAALLTALLSATRVAAHGHVENIVINGASYEGFDINVFPYESNPPAVVAWTTPNTANGFISPSQYNSSDIICHESATNAQGYATVAAGDSISIQWTAWPSGHHGPVLDYLANCGSDCTTVDKTTLEFFKIDGVGLIDDTTVPGNWGTDELVADNSTWLVTIPSSIAPGNYVLRHELIALHGAESADGAQNYPQCFNLQITGTGTESPAGTLGTELYTETGAGIIVNIYSSLSTYTVPGPTLISDAVSVTQSSSAITASVSATTTAAAVATGAASGSSSAAAAGTTSSAAAAASTSAATVASSSAAAAVVVSSTSTAVPTTMVTVASSATSAAAAVTSSAAADDECDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QZ92</accession>
    <name>A0A3D8QZ92_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteophosphoglycan ppg4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09757</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW67008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QZ92"/>
    <dbReference type="OrthoDB" id="5341904at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="257"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="751"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="823"/>
            <end position="855"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="878"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1148"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="573"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="946"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="996"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1039"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1087"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1156"/>
            <end position="1177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW67008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1261" mass="137513" checksum="E588727BDA91E90B" modified="2019-01-16" version="1">MGNSQSAETPRKLGKQPKTVPNKLTKPKTNTNTSTPTLLGQNVPTATSRRNSQASLPAQRFPSVRPLNKRRSTYASVEAVVDFPEEITPPEEEKKKRRSSIFRSWSISKHAPTPVATPVDAQTFETSAFEPMAFDPNVVERWSRSNSITAEMAGEELASVVPDIRPLPNPRASFIQRQVYSHQPRLSLVVEQLSPAPTPSLQSDEGNKRFSRLWASHKDAGSSTSSSPSSPIPERANPEAAVYAPIRRRSLLTPGIATRNSYIEPSTTSRQSLPSQVKAPSTSDELRRYFHSPRKQPPPQPLADLPAPGQYFTDAPRALTPTELDYGHIGAFKLGSLRITNGCASPTPSDNRSLTMGAEDDYFKQADPRPSTDSHRHAHRRSNTLTVANEIIKPAWKTDSTMRPEPGPPEFKHLAEATAANEAKNAAVDEDFAFNFRLQESPTKALELANEYMSDIAMSPFSFEATPPESPSLQTTSKHTAMEDDLFAVEAEGIPPIEESHGSSIDSGYHGEAAARPEEIKESGSLPKPLAKADSGYSSNASLRSLQNASSHLVPAKESTPTPPQESRPKMVSASFSQSSAASDKTVRARHSLPATTVNLPKMPQRDAPLVPGEIRSGPALPMESAEQKWATSEAPAHVATHQRQKSLPDQTGLEAGNNSRGRVRKARPVSVQPIFTIQAQRSQDKLNVPPVSSQAEQQLQNRVSGVPVAASSNTMSNAPSKETFKTILSVGSAEFREDRSAVDRYQDTMPALQSSAPAGKMAQKSDANRRLSYQAPVQAPVKAPSKLNKFRRSIQGPLVSTPDESFRTNDFETHLTSYDQISSSLGKSPYDRALGALSEPNTPKQKARTAPVETETNIAKLTAAAALQPKINPTAGVVPAQKTLTPEQRANLAREQFSRSRSRSSTRHETHSQQSYESIARKNPYADSRSSSRDRSRSRSHSRSRTRDDEMKTTEPDAPPLPKAPTEDDLKKYTKKLKSPPPVSMLAHRSMSLPGGTTPNMNQAQKSPEVPGRAAPPPPSSSADPWTAQKNYWSAQRKSLEQRKSLENVRPVALTTRKSTETVRSAGTPRRSMDKSPARPNLVKQKSVDLHKARSRKSLDHAQTPRKHQLSHHMSFDSHRQSAYDYGGQLSLSVSDAYDSTYGSGIAPAPSSTGSSLQSNTYYESSSSKSSTNDDLNATSRIHQRVNSTSDMLGLDHRFAGGLGYGFERTSAAQGDGESRYALVASAGSGMGGRRKSLGVRDEYGIDFSDVPVFVTRVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R2P0</accession>
    <name>A0A3D8R2P0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7896 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_08944</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R2P0"/>
    <dbReference type="OrthoDB" id="5377599at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057218">
        <property type="entry name" value="DUF7896"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42031">
        <property type="entry name" value="KEY LIME PATHOGENICITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42031:SF1">
        <property type="entry name" value="KEY LIME PATHOGENICITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25438">
        <property type="entry name" value="DUF7896"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7896" evidence="2">
        <location>
            <begin position="418"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="312"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="312"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="478"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW68287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="634" mass="70894" checksum="5432449234AE97BA" modified="2019-01-16" version="1">MSNITDIERKRQLLLAQLAELEAIQSTSPSNASPQYFRSPLQRHQHVPRSMSSSGTTMARHPSHRVDKTQRQRALSQHTAPGVSMARTNSRGAASARAGNLPFTNSGSVPTPVFETRREHPDVDAWVEQPFNTYTFNHQQASLEHVPEHRSNVLEDPADFLNRLGTPALSFTPSPMSMPSEAMNHRHSFSSHHAFGIQTPTTPAESLTTATTLASEMSRQNSLCNEPFIQSVEMMKFNSNSSYHPENVIDESQPFPPQYISYASRRSSKEAQSQIVFGAGASHESSFSHSFSSPETVAQFPSECLVDNMERSFSNESASSTSSTASRNKARLQAQNQHAAKRVLAPKGGSDETPMSRESSTQSVTPKNGSQDKVAISKPSYVRPKHDRVQCHQCDEHPDGFRGEHELRRHQDRVHKAMVKKWVCIEPTGQGHPKPILPLSRCKTCTHAKKKYGAYYNAAAHLRRAHFKPKAKGRSKASKNEKESEKRGGKAGGDWPPMSELKHWMIEVDEPATEFTQQQQQDEEEDEEVAEHASKNFIDNNFDFANPSIPTAYPNMHTQQMYADQGMQLDHSQQNIDMSMQFPSSTQNPGFESFPPTLLSNDASAPFMFDHSSFIDQSVGLDFVQHLNSNFSYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R2Q8</accession>
    <name>A0A3D8R2Q8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_08964</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R2Q8"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF40">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="2">
        <location>
            <begin position="124"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW68307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="564" mass="64363" checksum="6DA04B5464229293" modified="2019-01-16" version="1">MSEMHPAGHLVYFPLARWCSWSTEEVDSSKSVMRLSFSSATNSFTKEPNLKAGPLGSPEMNRSRDHDIVMHDDDASLAPPGSQSHQMSASTQSVVAGLSPVAMMDRQFPTDVLCSRPMLVCMLNDYLDLIYPLIPVVHRPSFRRDLAKPRDLEDPDFLGLIVAMCAAINAIMPRKFREYRSAISPLKYQTRTEMINHCCDIYLGLRSPEYFDEINHQKWAASYLLSIAFFQIGQHNRARMIEVEAMQLARLLEIHQISSYDGLNCIETQLRKKAFWLMFYGYVHSQLQNLRKERLTFLDAPILNNIKLEELMPLEVDDELIHEDVVLPQPASELSLTTGFNIHSRIFWAALTNIPAQDSPVLAEPCDCQRSRNPVLQYEHLEGRVQQLKYMLDDGLPMQLRQWSTGNIEDPTESPGSEHRRVVRSQFEAMRANIHVTHLWLQSIISDQIDTIRPSAGDLQATGDQRLLWGAREDLCRQLLHVLHSIEGVHLEPNGHHLTETHDMQSPGGGERSTSAAFLLCKRHLDIIRRVIVEAETAPDASVTPRIRCRYKVGRQIMFSPMMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R334</accession>
    <name>A0A3D8R334_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_09116</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R334"/>
    <dbReference type="OrthoDB" id="3639251at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF39">
        <property type="entry name" value="TRANSPORTER LIZ1_SEO1, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G00980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="152"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="469"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="60"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW68459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="513" mass="57616" checksum="2664B41142E77D33" modified="2019-01-16" version="1">MTLVRQALRVEYVRLPNSESVTSDEIQDYEKPPWSSYIWDYEPTRSHEEREFVRKLDWYLLTILSLGYFIKNLDTTNISNAYVSGMKEDLRMDANHLNMIDVAWTTGYVIGQLPSQLILTRVRPSIWIPCCEIVWTVMTFCLAAASSSSQVIALRFFIGLAESIFYPAAHYLIGSWYKPSELGKRACIFHASSAAAGMFSGYLQAAVYKGLNGTLGHAGWQWLFLMDGIISLPIAFAGFWLYPDFPDSTRAFYLTEADRELAKTRMQEIGRKERTKLGWGVLRRVFGRWHVWALTVLYIIFINTGPSSSVSPLSLWLKSQKYPVSLVNIIPTGQSAIQLVTTIGFSILSDFLRKRALIMSISTVDWSFPLPPCTKPTKETIQTLGLLAALLLAIWTIPAGLKWFAFFIGRSSVAYGPLSMSWANEICSGDAEERALVLGIMNAAGYAVHTWLPILIYPTTDSPQFRKGFTFTTVTFVAQFGITGLVALLQKREAKSKGKSEEGEEERTGLADI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R3A6</accession>
    <name>A0A3D8R3A6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_09189</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.9" evidence="1"/>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R3A6"/>
    <dbReference type="OrthoDB" id="2017317at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935:SF0">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="62"/>
            <end position="67"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW68532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="344" mass="38673" checksum="8D5D8146566BE16F" modified="2019-01-16" version="1">MSSSTAAHNMQGRWCFSSVIRKVQVTEAATAAHHERPALKIPETAPSRLYEEPCISTSTVLYLAYGSNLSAETFLGARGIRPISAANVHVPALDLTFDLAGIPYKEPCFANSRWRKMNPPYPPSPPDRYRKNRWYKGLVGVVYEVTLKDYATIIATEGGGASYEDVVVPCHPLMKGAKTIDQVPTTKPFMAHTLLCPMLPTATTGGSIQRPDPSYAQPSARYLKLITDGGQEHHLPEEYMRYLCNIRPYTITTKKQKIGSYIFLGFWFPIIMFLLRVSKLLADNEGKSPAWFANVMDFAFRSVWLSYDNLFKKTFGDGERTMEEEDDEEARVGNWNEKLGAIRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7D0</accession>
    <name>A0A3D8R7D0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dipeptidase</fullName>
            <ecNumber evidence="2">3.4.13.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_08283</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>an L-aminoacyl-L-amino acid + H2O = 2 an L-alpha-amino acid</text>
            <dbReference type="Rhea" id="RHEA:48940"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:59869"/>
            <dbReference type="ChEBI" id="CHEBI:77460"/>
            <dbReference type="EC" id="3.4.13.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.13.19" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW69886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7D0"/>
    <dbReference type="OrthoDB" id="445695at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070573">
        <property type="term" value="F:metallodipeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01301">
        <property type="entry name" value="rDP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008257">
        <property type="entry name" value="Pept_M19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443:SF12">
        <property type="entry name" value="DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10443">
        <property type="entry name" value="MICROSOMAL DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01244">
        <property type="entry name" value="Peptidase_M19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51365">
        <property type="entry name" value="RENAL_DIPEPTIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0224">Dipeptidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU341113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW69886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="387" mass="42689" checksum="8FE252F19B8C5C18" modified="2019-01-16" version="1">MSSWTHPYQELAIDERVKRVLAHTPLFDGHNDLPQMPRAVTHGKIYDQPKFDFENGFERGMTDIPRLREGAVGAQFWSICVPVIHEGEDFTTADYCDMARDCIEQIDMTVRLVENYPEVFELVRESSDVKRVYGQGKISSSIGIEGLHMAGNSIAVIRAWYQLGVRYCTMAHNCNNAFADSSQSKEGPVHGGLSSIGRSAILEMNRLGMIIDLSHVTPAAAAQALELTRAPVMFSHSNAQAIFDCPRNIPDSILDLVPVNGGVVMINFVPEHVATNRKDAKMGDVLDHIFYIANRIGWDHVGLGSDFDGVISTISGLEDVKSYPKLLAAVLDRGATEAQLSKLVGENILRVWSGVAATRDKWRWRALSRSRMCGKVEGGGGTTKSTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7G1</accession>
    <name>A0A3D8R7G1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xaa-Pro dipeptidyl-peptidase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_08380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the polyketide transferase af380 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW69983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7G1"/>
    <dbReference type="OrthoDB" id="2498029at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051411">
        <property type="entry name" value="Polyketide_trans_af380"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751:SF2">
        <property type="entry name" value="DLTD N-TERMINAL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G00380)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47751">
        <property type="entry name" value="SUPERFAMILY HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G16580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase-like" evidence="2">
        <location>
            <begin position="49"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00029464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW69983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="299" mass="33049" checksum="6D8B3A1A156F5049" modified="2019-01-16" version="1">MSHHQNVEFKTLDGIILRGWLYPASKKGPAVVMTPGFNCVKEMFIPEVAEGFQAAGITALIYDPRSTGESDGIPRNDIDPMKQVEDYSDALTFLARQPSVDPNRMAFWGQSFSGTVALCAAALDKRPKLIIAICPLLNFEYSKDKFAMILMKTMKDRESQVKGNKPFYLPVLTDKGENPAGFGIGADKEGFEYVLKAKETVAANHDNRTTLQTYYKMVLWQPHGLMKYVTPTPVMMVVPELDKISPPEHQLALFDTLASPKKKHIALGKGHLNVLSGDDAPELMQMQVDFVLAALSGAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7S4</accession>
    <name>A0A3D8R7S4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">UPF0220 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08509</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7S4"/>
    <dbReference type="OrthoDB" id="4188844at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW70112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="152" mass="17078" checksum="15E9C4E20A67259F" modified="2019-01-16" version="1">MMPERRQATSSSTTSRPTSTGVRRNLFHQHLSRRPTTSSTSTSAETLRLDLEPDSGTSDIVIRDKNGDIQICDPPLQSLDETEDGAVGDAHEDEKERQRLADAVRHHQRDRNRAPSEPAELLEAVKTSLRNKTAALAEDNWMYEAEDEVVLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8C9</accession>
    <name>A0A3D8R8C9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_08696</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8C9"/>
    <dbReference type="OrthoDB" id="3548654at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF32">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="144"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="192"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="199"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW70299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="727" mass="81170" checksum="C3C2611E5A7968ED" modified="2019-01-16" version="1">MVKLLKVKGSSYYLVALPNSEVLQDFLTPTLPMVEWVVSRTFSTHSMEWVAKASTHRGCTQWGPMTHPPAQSLIDYCTDAVNHSATIASRIRNRNGLRVRGNNPRFNAVDISVPQTSDLLNITEATSRMDSTTTSARPGRRSNACRRCRQRKIRCTGSQPCANCSRRNFDCIIDDEGRRIVVSQRYLRELQQAAGSERTQAERASKESESGHATLPQLPAPGDVDNRESLNLPSSHGAQVPVTYLHQVQTNPPVPQVPTLELVNPLATTNSSYLSDGAGRPRSLGESSLWACSRRALDLIRSQLDSAESPEIQLNEESLAYHLSWGSHVLDNESITSDLPSIDHALYLLNGVKFHVGQMYHLFDENEFMTHFHEFYKSPAEISESRRIWFVHFLALLALGKAVSVAPLKGATSPPGANFFLRAMNLLPDASYLFRDALTAIEALCVISLYLQLADMRNSAFIHIGQALRMALVFGLHRDRPLQKWDEQATARCIEVWWTVYILDRDFTSTMGVPTSINDNDITTPMPQPQGYQKNTALHLHVRLSRLVAQVVNKCSLPFDLERIFSAAFVHLMSSFITPGITNPYPLREEFILVLDELVARGSVPARFRKADLEALENMMRQWDTSKRSNESINGFSNYQGADSMHQHIPSQASLEEEDSGATISRPEQLYGGLSDGLSIGQILNVAQIVDVQQDMLNPGIGWAGSWLWENEESFGVSDNPIGFHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCJ2</accession>
    <name>A0A3D8RCJ2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative SAM50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_07779</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SAM50/omp85 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RCJ2"/>
    <dbReference type="OrthoDB" id="1724197at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045040">
        <property type="term" value="P:protein insertion into mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.50:FF:000008">
        <property type="entry name" value="Mitochondrial outer membrane beta-barrel protein Tob55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.50">
        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039910">
        <property type="entry name" value="D15-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815:SF18">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY COMPONENT 50 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12815">
        <property type="entry name" value="SORTING AND ASSEMBLY MACHINERY SAMM50 PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1134">Transmembrane beta strand</keyword>
    <feature type="domain" description="Bacterial surface antigen (D15)" evidence="7">
        <location>
            <begin position="171"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW71745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="514" mass="55127" checksum="5E4DFA0D49412CAC" modified="2019-01-16" version="1">MASALDPEDDVFESLRKRNPKQDEERAKAAEERLHAQYAKAQQRLGELIGSNSTLPVTISSIHLIGAARTRRSFLDRLFEPILSVNKDRPYTLSEALQEVGNAADKLRRFDIYHDDIAMFIDKPSKTDPSTSVSDIAFSLSAREKSRILMKTGTDLGNAEGSAYGSLLWRNIFGGAESLNLNASAGTRTRSAYQAVFDTPILSDPDKRISVDVLESSTSKAWASHEEALKSGGIKYSWATKSGTRHQLGYTGVWRQVTGLAGNASPTVRNDAGDSVKSSITHTWLADRRNHPFLPSRGYMVKTISEIAGWGPLKGDVAFWKSELETAGAVPIPIPGVAGDSGVSLSAGLRAGMLYPLPVGFGSQSQPSRINDRFQLGGPTDVRGFAMSGLGPRDGPDAVGGDIFAAGSCNLLMPFPRVGKDTPLRFQLFANGGRLLALNNAGEKGNQGSSSVQQSVYSTVAELGNGLPSIAAGCGVVYAHPVARFELNFSLPLVLRKGEEARKGLQFGVGINFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCZ0</accession>
    <name>A0A3D8RCZ0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADF-H domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_07822</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the actin-binding proteins ADF family. Coactosin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RCZ0"/>
    <dbReference type="OrthoDB" id="20822at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030427">
        <property type="term" value="C:site of polarized growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000018">
        <property type="entry name" value="Coactosin-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829:SF56">
        <property type="entry name" value="ADF-H DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10829">
        <property type="entry name" value="CORTACTIN AND DREBRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="6">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW71788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="146" mass="15845" checksum="FD20160DE9825C53" modified="2019-01-16" version="1">MSGANSPEILAAYDAVRSDKDETNWLIISYAAASGDALALTSTGTGGLPELAEKLDESQAQYAYVRVEYANDTESKRVKFALVIWIGEGTKVMRKAKVSIQSGEVKRVLNHHSIQIDAREKSDLDEAEIVKRLRKAGGADYNGGRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RD72</accession>
    <name>A0A3D8RD72_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_07930</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RD72"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF19">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017793944" description="Heme haloperoxidase family profile domain-containing protein" evidence="8">
        <location>
            <begin position="19"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="21"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW71896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="238" mass="25260" checksum="B42A704BB915237A" modified="2019-01-16" version="1">MKLSLLALSATLSTLVVADSVAHPYVAPTSSDRRSPCPMLNSMANHGFLARSGVNISMSDLISAFDAAINMAADAAELVGAVALTASTTGNASTFHLDDVDKHGIIEHDGSLSRADIYFGDNHSFNASIWNGTKAYFTDEIITISTAATARAARLALDATQNPTMNITTSQYTSSLIESSLYLTVFGNPVDGNASRSYVEAFFEEERLPYHLGWVRPTFGSNVTTLETLAGKIAAVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDE2</accession>
    <name>A0A3D8RDE2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deacetylase sirtuin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_08024</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sirtuin family. Class I subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDE2"/>
    <dbReference type="OrthoDB" id="420264at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046970">
        <property type="term" value="F:histone H4K16 deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF9">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="9">
        <location>
            <begin position="162"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="336"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="337"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="290"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="325"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW71990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="493" mass="54518" checksum="5CB8DE2D2A27BA0A" modified="2019-01-16" version="1">MATSAKVNASLKQPAHPVSTAVIDEDPSVEGEIDGLPRVHVHVPLDESDLEEAAEADGELDEWEDTESLYGDVLQEMGDDQLFDGEPDACTLEEAVAFRQQLRAIGPMEFCRTTVEAGTISAKKLLTAFGLKPPPFLEGEDDDAYYPLLSLALSRELSKRIKLTQYNSVDDAVDLIKNAKNIIVLTGAGISTSLGIPDFRSKDKGLYAKLEYLGLSDPQEVFDINTFRDDPSIFYTIARDILPSTDRFTPTHAFIHLLQQKGKLLTNYSQNIDNIESIAGILPEKLIQCHGSFATASCVECKYQIPGETIFPDIKAGRIPKCPKCIASLKAQAGTSMKRKRSQNGQSKKRGRYDSGDDDSSDDDLDTAKGGIMKPDITFFGEQLPDRFSDRLTNHDKHLVDLVIVIGTSLKVAPVSEVVPYLPAHIPQMYISKTPVSHVNFDIDMLGECDVVVAELCRRAGWDLNHEMIPEKQKLDIKLQDGFTSRHLFSTEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDK4</accession>
    <name>A0A3D8RDK4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">V-type proton ATPase subunit C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_08005</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.</text>
    </comment>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. Reversibly leaves the enzyme after glucose depletion, causing the catalytic subcomplex V1 to detach from the V0 section.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the V-ATPase C subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDK4"/>
    <dbReference type="OrthoDB" id="6605928at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14785">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000002">
        <property type="entry name" value="V-type proton ATPase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1460.10">
        <property type="entry name" value="subunit c (vma5p) of the yeast v-atpase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1180">
        <property type="entry name" value="Vacuolar atp synthase subunit c, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004907">
        <property type="entry name" value="ATPase_V1-cplx_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036132">
        <property type="entry name" value="Vac_ATP_synth_c_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03223">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118203">
        <property type="entry name" value="Vacuolar ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 6" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00053565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW71971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="394" mass="44055" checksum="C64E464C0B36E804" modified="2019-01-16" version="1">MSDTKYMLVSLPTSIAPSGDKDEALAALRSTVSTDNGTVLPFKVPDFKIGTLDALVQQADDLAKLESSCEGVVAKIGDSLKSLLEGDEDKIAQQKTVNDKPAEQYLRTFTWNKVKYRADKPLAELIDSLQKELVSIDNDVKAKMTQYNSVKTNLTTLQRKQTGNLATKSLTPVVDPKLLIQNSEYLETHLVAVPTNLKKDFIKSYETISPMVVPRSSIEVAKDDEFTLFAVTTFKKHSTDFQHKCRENKWTPRDYKYVEGGKEEERKEVERVARDERKVWGEALRLSRTGWSESVMIWIHVLTLRVFVETVLRYGLPLEFICGLVKTTPKLAKKAKASLDSTYSYLGGNAFGRDKKGKVTKDDSALSSEMAAAGVGGGDGNEYTAYVYYEFEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDN7</accession>
    <name>A0A3D8RDN7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome c oxidase assembly protein COX19</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_08018</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for the assembly of mitochondrial cytochrome c oxidase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the COX19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDN7"/>
    <dbReference type="OrthoDB" id="268594at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051383">
        <property type="entry name" value="COX19"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21107:SF2">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00037279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW71984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="104" mass="11596" checksum="015F58C5C26E8B0E" modified="2019-01-16" version="1">MSTLGGPGGRQINSKPTPPERGSFPLDHDGECKDVMTSYLSCMKKVRGMNNPECRNLAKSYLACRMDRNLMVKDDFKNLGFKEEKPAEPAGTKESGTKQGELRW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDU0</accession>
    <name>A0A3D8RDU0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_08239</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDU0"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF16">
        <property type="entry name" value="ANKYRIN-1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="4">
        <location>
            <begin position="26"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="5">
        <location>
            <begin position="323"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="931"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="964"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="997"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1030"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1063"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1096"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1129"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1162"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1195"/>
            <end position="1224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW72205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1224" mass="136999" checksum="C6F22C1730315DC9" modified="2019-01-16" version="1">MRLLTYDSAGQLSLTSEFVDDNIPRYAILSHTWGADREEVTYQDLVDGTGINKSGYKKIYFCGEQARRDGLQHFWVDTCCIDKKNSVELSEAINSMFSWYQKSSKCYVYLSDVSTNGNHQSAFQESRWFTRGWTLQELIAPRSVEFYGADGSLIGDKTSLEQQLHAITGIAVSALQGTTLSMFSFEERMSWANARETKREEDKVYSLLGMFDVHIPLIYGEGAKNAFERLREKIYKRGKKRQLDDVSTVFQATPTSAKRQKTSYNESFVISRRNTSLPDLSLASQPNYTSYSIDATTKQSLIDQLYFTKIDERLTSLTAAQGNTCRWFLAKPEFIAWHTLAQLPDHGGFLWIKGNPGTGKSTLMKFLFEDAKLNAKGDPSKITLSFFFLARGTVEEKSTTGLYRSLLHQLFAKDADLQDSLEWMTADGARVLDRNGWHEEALKQTFTHAIRKLGSRTLTIFVDALDECDKDHATGMVCFFEELCDCARETQVRLQICFSSRHYPTITIEKGIEVTLEAEIGHTEDLQKYIKSRLRLGRSTQAQSLRSEILEKSSGIFLWAVLVIDILNSEYPKSSGSTKKMRERLREIPPGLTELFKMILARDGENLEQLEICLKWILFAAYPLKPEELYFAIQLGLEKECSGFWDQEDIDLNQIKTFVRSSSKGLAEVTRTKASHVQFIHESVRDFLLGKYEGQWSGDTGNFVGRSHDILKGHCFSQLNTSISQEVDITDPLPKASDTGSLRENLKLKFPFLEYSVLNVLYHANIAQQNTIDQGESLTNFPLQQWIVFNNILEKFDIRRYRNRKSVSILYILAEKNFADLLRIHPQRASCFEVEDERYGPPFFAALATGSNETVRAILDLEAENYPLASPIHDLCKKYYGETHKRTGLGRDFAFSWHDAALSYVVKCRDETLLSILLETGKYMLNGKDIKSWTPLLWAASGGLEAVVTLLLEKGAEVNLKDNSGQTPMSWAAMGGHEAVVKLLLEKGAEVDSKDNSGCTPMYWAARKGHEAVVKLLLEKGAEVDLKDTSDQKPLSLAAIGGHEAVVKLLLEKGAEVDSEDTSGWTPMSWAAALGHEAVVKLLLEKGAEVDSKDISGRTPISCAAINGREAVVKLLSEKGAEVDSKDSDRRTPMSLAANGGYKAVVKLLLEKGAEVESKDTRGWTPMSWAAAHGHEAVVKLLLEKGAEVDSKDNSGRTPMSLAANGGHEAVVKLLLEKGAEVDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RI40</accession>
    <name>A0A3D8RI40_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_07157</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RI40"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW73715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="255" mass="27537" checksum="B2906F198E110D50" modified="2019-01-16" version="1">MAPIAMEDIDHTIHAGFHADEIWEPAPRTLPTDYVRHPTEVSKHLSASTTPRPNQARFATQIDQHASEPPSVAEDPRGDCRLVCRRLAEIGRSLPSRDRQKGVRRGSTVHLRVRDSGGHSACSSLGKLADEGPGHATPAASDARTLTASPEHPSPVHHHHQTFPPAKPGARRGSFSPSNLFPSTTEWVIGCFGKSSCPLLLLPSPNKSLMDCTCSLPPAFFSSADRHGFLEREGDWPPASVAAGWKTVCQNGMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIG2</accession>
    <name>A0A3D8RIG2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_07275</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10255000at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012943">
        <property type="entry name" value="Cnn_1N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019528">
        <property type="entry name" value="PACT_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47357">
        <property type="entry name" value="COP1-INTERACTIVE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47357:SF1">
        <property type="entry name" value="SPINDLE POLE BODY COMPONENT 110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07989">
        <property type="entry name" value="Cnn_1N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10495">
        <property type="entry name" value="PACT_coil_coil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centrosomin N-terminal motif 1" evidence="8">
        <location>
            <begin position="184"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Pericentrin/AKAP-450 centrosomal targeting" evidence="9">
        <location>
            <begin position="1272"/>
            <end position="1341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="742"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="914"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="968"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1004"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1167"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="924"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="973"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1009"/>
            <end position="1022"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF10495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW73833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1370" mass="157428" checksum="0CC04BD493F4EE91" modified="2019-01-16" version="1">MVQAGVGGLDTPRTNLGDATYLTNQLDFDISQEQSFQSPSKDNNNLLQQLQNGRRGGASLRTPRSRAVFGDRKNLPVGLGGGEFTPLLKSATRNSALRNGKENGLPQTPAFLKPGGLEALPEELSPLPAMGSSIYGQDSRNGSYMGGTPMAHIDSSSAASTPMAILPRRNEGGVGVLQDGNQLSLREQENVIDKIEKENFGLKLKIHFLEEALRKAGPGFSEAALKENTELKVDKVTMQKELHRYKKTLGAAERDVEIYRQQIIEMQERVKRKHADEGQEEELERLRNILKERESEIDRLRDHIEDAEHQGGQLEEFQDKMHDLEADVREKDRLIEDREDEVESLKARVEEQLDTISDLEEAAKKAERRALELEEKAQSNEELDRAHETIEDLENDLQRLQEEMDQAKEQCDEAIKEKERAEADLEELQDEMANKSVTTKGLSRQIEEKANRLQDDLEDLQEKYSALELKHEDKNREARSLQDRIESLLQEIDTREQKLQNQLENANAANQVTVRERDALSAKLDSLQQDLRQKADEKDLLQIRHDALTSESASLQRDLTKARATIEELEFKLEHEKTLALNNERNIGDEYKTEIERLNDEVEDLRAELREGQRQLDDDNDKWDITRRNLESERDIAEQEAAGLKRTIERLQEAEGTLSGKEMKLKEAIQSEKERHETQEALLVRQIDELKEDIEDRQRAFEEARSELLRYQDELRVSQREQKTLTEKVEGLEDEIEILQNGLDEDNDQATQEHSLAKKESDELRKQLRDLKSELDSAKLTRSESISHQRLESMLQDSEDQLAKIRREKQTLQDQLANVNIEMHNIRSTAAKADAEREELKAQLKAIKEQEETMRLDQERVDLRTTKMKLDIEVRRLRDENGILLEQQQGIEQQLQIEIARAATEEDRLQHEIRSLQRKTNGSPERELNSAKRTIKDLEEQVYELEQRMKSGNDRNDASSQLELARQTLSSARRRETEYQRREGAQKDALKSLMRQIKDLESRIDENEASQISVSSPHTSVKGSARKSDSTELRHQLSIAQRTVKDLQSQLREVVRDSARKLQAAANEMEAQAATLEAERNSLRSDLDDAIFERDQLLAKNASAETTFSKLRSKIDRLEKELQSERLNNGEDRTIALERRDLHDMLRETKLQAETLEVVVKERERTIAAVNASERELRTKLDRVREERSLQRTKAASAQEQALFLEKQLRAAKEAWEDEKRSLTRGVRFPNMSVSEAGNESMIKLAVEQRELRHNKELRGLAMQIEYLRACLIREQNLRANAAYIKSMLEGKIDFFKACNAADMKLLGIKPRVHEPKKRTLKVVATMVLAATRMQKLAAGWRSNKAINDKLQAYLKEARRKQGRKISGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJ29</accession>
    <name>A0A3D8RJ29_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Eukaryotic translation initiation factor 2 subunit gamma</fullName>
            <ecNumber evidence="2">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_07380</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJ29"/>
    <dbReference type="OrthoDB" id="1045173at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01888">
        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000009">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000011">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000065">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050543">
        <property type="entry name" value="eIF2G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
        <property type="entry name" value="eIF2g_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003077">
        <property type="entry name" value="PRK04000.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="11">
        <location>
            <begin position="84"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW73938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="514" mass="55716" checksum="60438B1174510314" modified="2019-01-16" version="1">MAANGDKYGNDMDSDSESDAGSQTQEYDDHVEELEKPSKSALKKDNRKEAAPAVIRPTLPPQTEPKDLDVKSLNPLTPEIIARQATINIGTIGHVAHGKSTVVKAISGVQTVRFKNELERNITIKLGYANAKIYKCDNEECPRPTCFRSYKSEKEVDPPCERDGCSGTYRLLRHVSFVDCPGHDILMSTMLSGAAVMDAALLLIAGNETCPQPQTSEHLAAIEIMKLDKIIILQNKVDLMREDGASQHYQSILKFIRGTVAGGSPIIPISAQLKFNIDAINEAIVSTIPVPPRDFTQDPQMIVIRSFDVNKPGAEIEDLKGGVAGGSILHGVIKLGDEIEIRPGIVTRDEKGAIKCTPIFSRIVTLNSENNELKYAVPGGLIGVGTRIDPTLCRADRLVGFVLGLKGRLPDIYIEIEVNYYLLRRLLGVKTADGKQAKVAKLAKNEVLMVNIGSTATGAKVVAVKQDAAKLVLTSPACTNVGEKVALSRRIEKHWRLIGWATIAAGVTLDPSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJ60</accession>
    <name>A0A3D8RJ60_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_07410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJ60"/>
    <dbReference type="OrthoDB" id="3561450at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017812057" description="Apple domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="278"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW73968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="478" mass="49085" checksum="3856EA8BFF5780F4" modified="2019-01-16" version="1">MYFFTALSVLALISNSVLAATPPLIEKDTGSKWALPWAEKQAYKHAYPPSYSYAARPSLLSTASSVFSQTGGAPFPTATGLVSGTGMLGTGTGTAYSSTSSATSSYTFACPNDTLIVNYITVTASVTSTSFVLFTATGGTSGFPSSSANSTGIYTLSPWNTTATSKPTVYLNVTTTYSGSLSSSTASCINETTSSALNATSSVLLNTTSSTLIVTSSAYTNTSSPVPTSIPTSNSSTVLNSTLSTAVVTSTSTIFTNTSGALPTSTPCSNSTPATNGTSSVYSTSSVPTSTALNSTTSPASTTSISSISTSLDSTTSFNISTTQTYTSTHSIEIFTVSTSTFTVTTAPTPITINTGTDLHPATSYTPTTVVTSQATGTPNPKALHCGLHGLPVGDYFLAEFVEEKADVAVTLEGCYQFCVGVYGIDMGCESYSFFPEVGTGAPRCDLYGGSVAQSLDSINDYVPNVWYDLGCGNPLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJ65</accession>
    <name>A0A3D8RJ65_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Inorganic pyrophosphatase</fullName>
            <ecNumber evidence="4">3.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Pyrophosphate phospho-hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_07448</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>diphosphate + H2O = 2 phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="EC" id="3.6.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJ65"/>
    <dbReference type="OrthoDB" id="1608002at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.80.10:FF:000004">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00040300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW74006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="290" mass="32682" checksum="826ED913D199E582" modified="2019-01-16" version="1">MASQYTVRKIGAPNTLEHRVYIEKDGVPISSFHDIPLYANEQQTILNMVVEIPRWTNGKLEISKEELLNPIKQDIKKGKLRFVRNCFPHKGYLWNYGAFPQTWEDPNVIHPETKAKGDNDPLDVCEIGELVGYPGQVKQVKILGVMALLDEEETDWKVIVIDVNDPLAPKLNDVEDVERHLPGLLRATNEWFRIYKIPDGKPENQFAFTGECKNKKYATDIVRECAEAWEKLITGKTQPGDVATTNLTVAKSPSRVTPDQLPPIPANQTLPAAPIDPSIDKWFFISGAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RNS1</accession>
    <name>A0A3D8RNS1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="5">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_06563</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the tannase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RNS1"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF7">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017496224" description="Carboxylic ester hydrolase" evidence="5">
        <location>
            <begin position="20"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW75742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="581" mass="62958" checksum="77054B7E7871013C" modified="2019-01-16" version="1">MRQAVRSTAVAALAAAANAATLAEVCTVANVQAALPANGTLNGINLIPSSVTANAVNDANSTTSSTAYNYCNVTASYVHPGKSQEVVVWYTFPSPDTFKNRFYVAGGGGYSLNTDPTGGLAYGAVAGVTDAGYDAINGVALDTVALAGNGSINWDNIYMFGYQALGEMTQVGKAITPAFYGLNTSSKIYTYYEGCSDGGREGWSQIQRYADEYDGAITGAPAFRYGQQQVNHLFANVAEQTLDYYPPPCELEKIVNITIATCDPLDGRTDGVISRSDLCKLNLNLNSTIGTPYYCAASTSTSLGFGFGSKAKRQSSTSEPAQNGTISAQGVALVERLWEGMFNSKGERIYVPWPTGSSFQDTATTYNSTTGDWDLSITSLGGEFVTKFIQLIDVSNLSSLENVTYDTLQDWMNDAMVRYMDSLQTTLPDLTPFQSKGGKIIHYHGEADDSIPPASSVHYYDSVRNIMYPTQSYNESITSLQSWYKLFLISGAAHCSRNTLMPGPYPEDNMATMIDWVENSIEPTGLNGTITSGTYSGEVQQLCAWPLRPFWSDNSTMSCQYDQKSIDSWTYTFDAFKVPIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RNS5</accession>
    <name>A0A3D8RNS5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_06431</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RNS5"/>
    <dbReference type="OrthoDB" id="448427at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000107">
        <property type="entry name" value="Mitochondrial dicarboxylate carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00784">
        <property type="entry name" value="MTUNCOUPLING"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="22"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="125"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="225"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW75610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="321" mass="35807" checksum="2F6026E991331EED" modified="2019-01-16" version="1">MSSGARSQMVKEDPRKKKWERGQVRYPFWFGGSASCFAACVTHPLDLVKVCRDRYGRPSVRLQTRNGNAPKTMVTTFVHVLKHDGFLGLYSGLSASLLRQITYSTTRFAVYEELKQALTTKDSSPTFPALIAMASASGFLGGVVGNPADVLNVRMQHDAALPKQNRRNYKNAVDGLVRMTREEGWKSLFRGVWPNSMRAVLMTTSQLASYDGFKRLLVKNTPLEDGLALHFSASFMAGFVATTICSPVDVIKTRIMSSNESKGLAKLLADVYRAEGVAWMFRGWVPSFVRLGPHTIATFLFLEQHKKLYRKLKGIDEVVVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RP77</accession>
    <name>A0A3D8RP77_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphoglycerate mutase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_06577</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RP77"/>
    <dbReference type="OrthoDB" id="354304at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004331">
        <property type="term" value="F:fructose-2,6-bisphosphate 2-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045820">
        <property type="term" value="P:negative regulation of glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043456">
        <property type="term" value="P:regulation of pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051695">
        <property type="entry name" value="Phosphoglycerate_Mutase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46517:SF1">
        <property type="entry name" value="FRUCTOSE-2,6-BISPHOSPHATASE TIGAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="105"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="298"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="2">
        <location>
            <position position="8"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="2">
        <location>
            <position position="89"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="7"/>
            <end position="14"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW75756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="35113" checksum="5C5583892FC25EA4" modified="2019-01-16" version="1">MRLLLIRHGETVDNVAGKYAGITDSALTNHGVLQANRLGSHLAASGVVASHIFSSDLQRAVKTADAIRAAQSQSEFSLKEVTKLTLLREQDFGFYEGKTFLERSGDSNKTGKDAHIEKHRNDPGFKDVESKDSMKNRMNDFINIHLLHLFQSVEDGETVAVVAHGIILSHLWRCILSRFPSSNVSVDTGVLAPDKMLSLEYLGGWSNTGYLDLEVKQMTKDVPKGSDVDTSKSTKTETGAIVAPAADVSSDKNSSASSALESIPVVPKAPLPKLSCLSLAVKAVNSLAHLKGLKKTRGGIGSLKHDSSQKTMDSFFKKRKRESP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPS8</accession>
    <name>A0A3D8RPS8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Calcineurin-like phosphoesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_06884</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPS8"/>
    <dbReference type="OrthoDB" id="9984693at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033308">
        <property type="entry name" value="PGAP5/Cdc1/Ted1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315">
        <property type="entry name" value="METALLO PHOSPHOESTERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13315:SF1">
        <property type="entry name" value="PROTEIN TED1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="520"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW76063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="629" mass="71555" checksum="5C7955A28E42D3E1" modified="2019-01-16" version="1">MFLVFVLRNALLFLVPVSLFLTIYLYAFPVFHACAFPAPDRDASSAYFNTVRQHAPFLSHDATAIAPFRLLALGDPQLEGDTSIDPNALSFPYLKKLRNNLLLNNENRDPWQRARHSLHDLVDFYFDDIPRALEVYRKRLDHVGNDYYLGHIYRKLHWWTDPSHVTVLGDLVGSQWIDDEEFESRGWRFWNRVFRHAERVPDELMSQPADDFQHTKELGEDAAGWKRRLINVAGNHDIGYAGDLTPERLSRFVRMYGKANYELRFHLPLDLKLLNQTSSDQVDLPGEPPELRIVLLNDMNLDTPAFSSELQDETYNFLNTVITTSHKVTRKALFTLVLTHIPLYKDAGICVDGPFFDFYEDGSGHGVKEQNHLSLDASKGFLEGIFGMSGSPNADGGGMGRRGLIMNGHDHEGCDIYHFINQTSFKLANEEYEKLISEDVLAEHLVSRPELPPWQAKRLRDAQAENLPSRTDLPGIQEATVRSMMGDFGGNAGLVSLWFDYEAWEWKYEFVNCALGTQHIWWLVHIVDLIVMIMVIVWAILSVVERVLGHQAQLKQRSHLNGAEKHSQGVNGNAGNKKLDDYNKIDLSDFEHVQIDEGWEGYPVSCASSCGAKHGKNESKGANGVRFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RQ12</accession>
    <name>A0A3D8RQ12_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">MICOS complex subunit MIC60</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Mitofilin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BP5796_06712</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 13">Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Mitochondrion inner membrane</location>
            <topology evidence="1 13">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the MICOS complex subunit Mic60 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RQ12"/>
    <dbReference type="OrthoDB" id="10261039at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061617">
        <property type="term" value="C:MICOS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042407">
        <property type="term" value="P:cristae formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019133">
        <property type="entry name" value="MIC60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415:SF7">
        <property type="entry name" value="MICOS COMPLEX SUBUNIT MIC60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15415">
        <property type="entry name" value="MITOFILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09731">
        <property type="entry name" value="Mitofilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 13" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 13" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="5 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="39"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="196"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="410"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="75"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="120"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDW75891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="680" mass="74298" checksum="1E2FA8FC3EE0DFEA" modified="2019-01-16" version="1">MLRASLQSARVFGYKPVVANAGRQWHAAKVGRAVSGGLRGYSDAKKPTINDSNPVVLPGSASDATSEPLPVGAVATSPSSRLATAPSTTATPTANATIPADSVPLTPPPPSKVQAAPPTSAGPPPSSIPPPPAPKPKRRIRRFFFTLFILGALGFGGGVYYSRINDNFHDFFTEFVPFGEEAVLYLEEQDFRRKFPRSANRNPARPRDSGEQVRIPSQSGVSWKVSDATKPEEKKSAEILQNPSEAKTSKQAKAVESVKKDPPAPAPAPKAPEPQVATKATPMAQESPKSTAFKAPEVDEPSRFPPALTHIDPINIKDAKEPLVQDLVKIINDIITVVNADNSNAKFSATIEKAKSELAKVGGKIQVLKDASLKDAESKVVASHEEFDRAAKELVRRLEGEMQGQELRWKEEFESERQKIQQSYEQKLKAEVDRANEVNEQRLKNQLLEQAVKMKEQFITEVKARVEEEREGRLGKLSDLSNTVTELEKLTTDWNAVIDTNLKTQHLHVAVEAVRANLEKSQVPRPFTKELAALKEIASDDPVVNAAIASINPLSYQRGIPSSAQLIDRFRRVATEVRKASLLPEEAGVASHASSYVLSKLLFKKNGLATGDDVESILTRTETFLEEGDLDAAAREMNGLNGWAKTLSRDWLGEVRKVLEVQQALDVIATEARLQSLKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RV78</accession>
    <name>A0A3D8RV78_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative alpha-1,2-mannosidase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_05819</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW77967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RV78"/>
    <dbReference type="OrthoDB" id="449263at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000224">
        <property type="term" value="F:peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006516">
        <property type="term" value="P:glycoprotein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1610.10:FF:000002">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.10:FF:000010">
        <property type="entry name" value="Alpha-1,2-mannosidase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2080.10:FF:000001">
        <property type="entry name" value="Alpha-1,2-mannosidase subfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1050.60:FF:000002">
        <property type="entry name" value="Glycosyl hydrolase family 92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.60">
        <property type="entry name" value="alpha-1,2-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1610.10">
        <property type="entry name" value="alpha-1,2-mannosidases domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2080.10">
        <property type="entry name" value="GH92 mannosidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014718">
        <property type="entry name" value="GH-type_carb-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005887">
        <property type="entry name" value="GH92_a_mannosidase_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041371">
        <property type="entry name" value="GH92_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012939">
        <property type="entry name" value="Glyco_hydro_92"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050883">
        <property type="entry name" value="PNGase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01180">
        <property type="entry name" value="aman2_put"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143:SF25">
        <property type="entry name" value="FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G10790)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12143">
        <property type="entry name" value="PEPTIDE N-GLYCANASE PNGASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07971">
        <property type="entry name" value="Glyco_hydro_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17678">
        <property type="entry name" value="Glyco_hydro_92N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017677288" evidence="1">
        <location>
            <begin position="22"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92 N-terminal" evidence="3">
        <location>
            <begin position="35"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 92" evidence="2">
        <location>
            <begin position="291"/>
            <end position="774"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW77967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="799" mass="87020" checksum="D6951B8C635D301A" modified="2019-01-16" version="1">MKVFEVLFGLAISFIVFGAAAAQIVTNSTYDVLQYVDQLIGSSNGGNIFPGATLPYGMAKAVADTDSGSNQGGFTTDGSNITGFSSMHDSGTGGSPSLGNFALFPYASCAGDDVDGCKYPKKERKTQFVNGSLQTSPGYFGLELASGVQVDMTTAQHTSLFRFKFPATNSSGNASSPLILMDLTDLSDSRQDNGSISVDATTGRMTGNARFLPSFGSGNYVLYFCADFSGAPIRDNGIFANSRASADVKDLKISRSINGYPLPGGAFVRFESPGDTPVLARVGVSFISSAQACSSAEAEIPTFDFNATYTVAVNTWREKLSPITVSTSGIDASTLTNFYSGIYRTMVNPQDYTGENPLWQSSEPYFDSFYCIWDLFRSQLPFLTILDPSTVTRMVRSLIDTYVHEGWLPDCRMSLCKGYTQGGSNADNVLADAYLKGLTDGIDWTTAYAAVVQDAEVEPYDWANEGRGGLDSWKRLGYIPVQDFDYKGFGTMTRSISRTLEYSYNDFVIAAMANGLGGLNTDVQKYLGRSANWQNLFKSDQTSFFNGADTGYVGFFQPKYLNETWGFQDPLKCSNVDTNPNSVCSLQNTGAETFESSIWEYAFFVPHDQATLITTFGGPAVFVDRLNYLHDNNITYIGNEPAFLTVFQYHYAGRPALSALRSHYYIPAFFQPTDDGLPGNDDSGAMGSFVAFSMMGLFPNPGQDVYLITPPYFESVSIKSPITNMTATIRNVNFDPTYKNVFIQNATLNGVPYSKNWIDHSFFTEGKELVLTLGATESFWGTNVADLPPSLGEYVGFGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVC2</accession>
    <name>A0A3D8RVC2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">beta-glucosidase</fullName>
            <ecNumber evidence="5">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BP5796_05780</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 19">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="5"/>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW77928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVC2"/>
    <dbReference type="OrthoDB" id="416222at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000757">
        <property type="entry name" value="Beta-glucosidase G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1700:FF:000021">
        <property type="entry name" value="Probable beta-glucosidase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF14">
        <property type="entry name" value="BETA-GLUCOSIDASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0964">Secreted</keyword>
    <keyword evidence="7 15" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017663382" description="beta-glucosidase" evidence="15">
        <location>
            <begin position="19"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type III-like" evidence="16">
        <location>
            <begin position="705"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="197"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="202"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="227"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDW77928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="786" mass="83215" checksum="E58A37C46D8BFD69" modified="2019-01-16" version="1">MLYKQLFAVASILPLIAGAKHQRRANSTSTNATLAAEGILSNGLVDLGDWADAYAQAEAFVAGLTNSEKISIITGGDVASANWTALQFKDGGQGPQGYDWTTGWGESSALGMTWDKAAIGRQFSAIALEFYQKGFQVANAPTSQPLGRTPWGGRLVEALGADPYLNGIAFGLGAKAFSDVGVIPGGKHFLLNEQETNRSASGGMGGGGGFGGGSPPGAGNMTLAARDTTTTESAPYSSNADDKTIHETYLWTFYDAVKNGLGGVMCAMTKVNGTLSCENADLLNTLLKTELGFPGLVFPDVNGQSSAYGSADAGLDYGSSNYWSNDTLGVGIANGSFSQARLDDMVIRNSIGYFKVNLNNGSQPALAGSSDFVDTMGNHSVIVRENGAASLVLLKNTNNALPLNKPRSMALFGSGAGPVMAGPNYVFDVTGAPSTYDGHLAGGSGSGQTSFPYLYTPNSVLTQRAAADHTMIRWILNNTYTTSSSSTLNGLSGGTAISQSVTSYATSAEVCLVFINAFSGEGADRTELKNDEQDALVNSVAAECNNTMVVINTVGARLVDQWIENDNITAVVYGGLLGQESGNSIADVLYGDVNPSGRLPYTIAKNESDYNVEICYTYNCNFTEGNYIDYKYFDKYNVTPRYEFGYGLSYTEFTYGNLTVNTNTTALSSIYPTGILTVGGKADLWDEVMTVTLSISNTGSVDGNEVAQLYVTYPDVADQPLRQLRGFEKVLIATGAQESVTFSLRRRDLSYWDVVAQEWAIARGTYTFSVGASSRDLRVFGTATVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVI2</accession>
    <name>A0A3D8RVI2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mediator of RNA polymerase II transcription subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8 9">Mediator complex subunit 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_05915</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Mediator complex subunit 14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVI2"/>
    <dbReference type="OrthoDB" id="205099at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055122">
        <property type="entry name" value="Med14_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013947">
        <property type="entry name" value="Mediator_Med14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809">
        <property type="entry name" value="MEDIATOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12809:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08638">
        <property type="entry name" value="Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26204">
        <property type="entry name" value="Med14_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0010">Activator</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit MED14 N-terminal" evidence="11">
        <location>
            <begin position="89"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="746"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1081"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="764"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1081"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1135"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1156"/>
            <end position="1168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00019619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW78063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1178" mass="132358" checksum="0D42B6B0F734BBFE" modified="2019-01-16" version="1">MPGVIMENTSGNGSHTNHDRDSRPNGINGASYGSDQGHEKGKGRAEPQQNMTPISPVISNGFNAHGGNGEVDRFNELPPEVQHLTEGYLPLSVLLARLAQSSHSNLTAKILQLAQMPLPNPVVNGHGGSAEKPEGNTSQENLQKKIAILKFAEDMHSNWTKALVLWNWSKNAADVSKMIDLRLYLQAQQSTYNMALDSMGVLKRDLAQARVPNPDLKTALEVLSTGKASWMPELGYIEPPPLTAKELLKTLENLNTLLTIRLNLHDYDKVPYQFKEYSIKSGRVTFSVAGEFEVDLTIADEDPESQFWFIDFRFLFSPSLSELTPSTRFHIESKVNVILKEDGLQGCYKYLHELVLTHKISEFRRQAVELARSRWIDSVKVEPLNRALCIQYWLDRYGRDGPKSWIIIGVHSGRRKDGQDDPRATSRLFIRWFRESKEVQDPDISFDAVDISAEALLKAVVAKHINYILGSTYDKLRSKALFSNNEAALSLHTSSTEPMESELKIQLSSKQHITTNIEPVSGRFTVSPASRLTFDFERTLNNRSRDPAKDAEEHIANLRCFAIAEAITSRGLSVGWQKPSPQPQISREDLKDVIPRNIVDSFLQIRWFKRPGWSSEWFVAVTLGVRGDKWWLFKTTNATTGTKVERAIEMPVKGSWASEPTFGFLSSLHIFSAALISQYTNLKALHERRIRYSLQESSKALPVRVPAIFMRLSELLPPRGSRRKPWARDVVKLVFQGLEVRSGETKVAATPTQNPSDNALPLSSAINGVSPSSQKPTSTAHGDSAVMITEARMIIPPAGNLSVLKERVDRDIAFHAESGAFAFRLRSEIGESVVPHLIQRVSQVERLVNFAEVVHKHEKFIHSQSISLGKIVFRYDNAQDKDMMDLDSSSRYKAIVDFSSVESAMTLSLEAKNPHIRILDNLTKILNSPEGLNGVATILPLTLPALHAVDNIETAWEDLSERGEVLILVRSTDWYIVRYNLFPADGKSRKIVLDVKLMTRRGEPWWYVRRTDHREKEGDDIDEKLKVVWNGSGAGWNGMRLSAVAEPSGVEECLGKVDEVIRKTLIQDQIPQAKPLAAPIAQMQPQAQMQPRAQMQPQAQMQPAPQMMPQAQMGQTQMQRQQQHQKLQQQRQLATPNSSQSQGRVTPNNSQNSQGRNPSNQNPNQARRQQPREIVEID</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVU6</accession>
    <name>A0A3D8RVU6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_06039</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVU6"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF6">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="3">
        <location>
            <begin position="86"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="352"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW78187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="542" mass="61705" checksum="F6F1412D9A6EA725" modified="2019-01-16" version="1">MLTWPAIQQLILQGLPTNVEDLKSLEQEGSAFIVRMQKGIPNLPMQVGLQSVPFVGMQTQASRAAGEARTTFPTLTREKMLHLATAYFDSFNLLYPFMDRQSFISEILTRVSTEGFHGDPDSVIALLVFALGEMALESAQGDPLDPHQGRSSGTVSRPPGLEYFNAARERIGFVLTECDLESVQIFSMAALYYESCSRHVDFWRLTVSASSACQVLVTCYPIDWKSPRGDLIKRAYWHCVIMETGLHLELDLPLTGIIDLEDRVGIPIFNTPFCEADHRANQASHFEAHYASQVALRRLCANLHENINGSMTDTSTPDSSLAEGGPTAHSLKQLAAQLAQWRSMLPRELQWDEDDPTSFPGPPQSPFNLDPKLPQQSRGGEPMFSEDLDSNQPTNLYLYDVQVALLRTRYYYAKYMVYRPFIYKALHFPEQMTQLDAEGVAECLRSCLRWPLTFSPASRKKRLIPYLFCWSQNFLGILLIIHLTRHNPMLRDIRTQLCGPRFEREIEQSIALMLDWIRDLKRSDPIAMWCWNILQSIYHMDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RW53</accession>
    <name>A0A3D8RW53_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">AP-2 complex subunit mu-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_06151</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RW53"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005905">
        <property type="term" value="C:clathrin-coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09251">
        <property type="entry name" value="AP-2_Mu2_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14836">
        <property type="entry name" value="AP2_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000002">
        <property type="entry name" value="AP-2 complex subunit mu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043532">
        <property type="entry name" value="AP2_Mu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043512">
        <property type="entry name" value="Mu2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0168">Coated pit</keyword>
    <keyword evidence="5" id="KW-0254">Endocytosis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="10">
        <location>
            <begin position="168"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW78299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="437" mass="49249" checksum="F1456CC8EFDAFB25" modified="2019-01-16" version="1">MLSGILIFNQKGENLIFRAFRNDCRPRLADVFRIQVISNAQVRSPILTLGSTTFSHVKHENIYLVAITKSNANAALVFEFLYRLIALGKGYFGKFDEEAVKNNFVLVYELLDEILDFGYPQNTETDTLKMYITTEGVKSERTMEDSAKITMQATGALSWRKADVKYRKNEAFVDVIEDVNLLMSATGTVLRADVNGQIVMRAYLSGTPECKFGLNDRLLLDGDSLSSLPSGNRMGTKATKAAAGSVTLEDCQFHQCVKLGKFDTDRIISFIPPDGEFELMRYRATENVNLPFKVHAIVNEVGKTKVEYSIAIRANYGSKLFATNVVVRVPTPLNTARITERCTQGKAKYEPSENNIVWKIPRFTGQNEFVLSAEATLTSMTNQKAWSRPPLSLNFSLLMFTSSGLLVRYLKVFEKSNYSSVKWVRYMTRAGSYEIRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWD9</accession>
    <name>A0A3D8RWD9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SGS-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_06225</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SGT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWD9"/>
    <dbReference type="OrthoDB" id="1898560at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06466">
        <property type="entry name" value="p23_CS_SGT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007699">
        <property type="entry name" value="SGS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044563">
        <property type="entry name" value="Sgt1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45862">
        <property type="entry name" value="PROTEIN SGT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05002">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51048">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="4">
        <location>
            <begin position="175"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="SGS" evidence="3">
        <location>
            <begin position="312"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="281"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="356"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="328"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW78373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="43843" checksum="571903A16DCDA8E7" modified="2019-01-16" version="1">MSSQAALGAKALEDRDYPTAIEQLTKALATNTSNPSPLWLIQRSTAYQRSAQYELALADADAALHAAKSRARREFIATAHFRRAVALHGLKRFGDARLCLNWCRKSNEKEKGLGIWQAKVKNDFDKAEKELGPDATEVRTTVKEIPDKVEEKAKEKSAPLAPAAQTPAPPAVTSKEKIRHEWYQSPSSVTITIFAKGVPKDKAEVMIGEQSVSLPTYILFNTTSYNFKLEVSFPIGTTEQTYALDFSPLFAKIKPAESSYNIFSTKVEIILQKATPGRKWSNIEGDESTLKDSSNEPLDNVMQAKTGDKGPVYPTSSRTGPKDWDKIDDADEGEDQDVNSFFQKLYKDADPDTRKAMMKSYQESNGTSLSTNWADVQKAPVPTQPPEGVEAKKWGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWT2</accession>
    <name>A0A3D8RWT2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aspartate transaminase</fullName>
            <ecNumber evidence="4">2.6.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Transaminase A</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_06113</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.1" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWT2"/>
    <dbReference type="OrthoDB" id="6752799at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004069">
        <property type="term" value="F:L-aspartate:2-oxoglutarate aminotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006532">
        <property type="term" value="P:aspartate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00609">
        <property type="entry name" value="AAT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1150.10:FF:000001">
        <property type="entry name" value="Aspartate aminotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000796">
        <property type="entry name" value="Asp_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006719">
        <property type="entry name" value="PRK09257.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879">
        <property type="entry name" value="ASPARTATE AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11879:SF55">
        <property type="entry name" value="GLUTAMATE OXALOACETATE TRANSAMINASE 1, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00799">
        <property type="entry name" value="TRANSAMINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="9">
        <location>
            <begin position="40"/>
            <end position="403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW78261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="411" mass="45368" checksum="DCE6A2176BBF0BF8" modified="2019-01-16" version="1">MGSIQASKTDQRSVFESAPYIPPDLIFEVTKNYLADSDPKKVNVGAGTYRDENGQPWVLPSVRMAKSLIADCGHEYLPIAGLKSFRTGVTELVFHDTNALRNDCIASCQSLSGTGALHLAALALKKANASNGEVYITDPTWSNHELLFESLDFVVHKMPYYKNSAFDFDGYMESLKAAIPGSAIVLHTCAHNPTGCDPSQAQWKEIASVVQDRQLFPIFDSAYLGFNSGSVDADAWALKYFIEECNIEVAVALSFAKSMGLYGERTGMVAFVTRSPELAVNLNSILENVQRATVSSPVAYGSHIVSTVLNNPDIKDQWAKDLVTMSSRIQAMRQKLYDELVRLQTPGDWSPIIRQSGMFGYTGISPTQIKHMQDKYHIYMADTSRISIAGLNDKNVEYFAMAIDSTVRNIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2T0</accession>
    <name>A0A3D8S2T0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">NAD(P)-binding protein-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_05264</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2T0"/>
    <dbReference type="OrthoDB" id="1933717at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43490">
        <property type="entry name" value="(+)-NEOMENTHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43490:SF99">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW80566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="265" mass="28562" checksum="EF1B8105776D5776" modified="2019-01-16" version="1">MSATPVSLLQLRILTTGANRGIGFSIIQALGTHLPDALFLLGCRSQEAGEEAVKDLRKRWSDAGIDGDGRKVEVLVLDVSDDKAIERARSEVERRWGGLDVLINNAGIAIPYGTGKGDLSELRLSFNTTMNTNVTSIAAVTEAFLPLLHASSIDLPKIINISSGRASLARSSSGTMAPTMVVSYSISKAAVNALTIEMQKSERGTVDVYCVNPGFCSTAFNGFKGTKDPLLGAEVVVRLILAERGIYRPGVFWEFEDGEMREVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S342</accession>
    <name>A0A3D8S342_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Isochorismatase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_05421</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the isochorismatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S342"/>
    <dbReference type="OrthoDB" id="167809at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00431">
        <property type="entry name" value="cysteine_hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.850">
        <property type="entry name" value="Isochorismatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000868">
        <property type="entry name" value="Isochorismatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050272">
        <property type="entry name" value="Isochorismatase-like_hydrls"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036380">
        <property type="entry name" value="Isochorismatase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540:SF16">
        <property type="entry name" value="ISOCHORISMATASE-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43540">
        <property type="entry name" value="PEROXYUREIDOACRYLATE/UREIDOACRYLATE AMIDOHYDROLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00857">
        <property type="entry name" value="Isochorismatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52499">
        <property type="entry name" value="Isochorismatase-like hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isochorismatase-like" evidence="3">
        <location>
            <begin position="5"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW80723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="208" mass="23358" checksum="0FFABB284A28582B" modified="2019-01-16" version="1">MSPKTAIVILDPYNDFLHPEGKLYHLLAESIKDTDTITHLKDLVTTARKHKIPIYYGLHQQCRPGFLAGWLHPTASQQSQLEHKAFEEGSWGVEFFEGLEPSLENGDVVVSKHWGSSSFQNTDLDHQLKQREITHLVMAGLTANTCLESTARYAYELSYNITLLKDATAGFSTPQKDAATELVWPLFSNRVLTVDGWKASLEEGSNKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3I6</accession>
    <name>A0A3D8S3I6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proline--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_05428</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3I6"/>
    <dbReference type="OrthoDB" id="1350766at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00862">
        <property type="entry name" value="ProRS_anticodon_zinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.30:FF:000001">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000007">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000005">
        <property type="entry name" value="bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382:SF2">
        <property type="entry name" value="BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="10">
        <location>
            <begin position="90"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW80730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="558" mass="63043" checksum="956731469199D565" modified="2019-01-16" version="1">MADAPQEPSKSAIKKAEKQAKMAAEKAAKAAKQTLPVVGGKKADDIIGITNSKAQNFSAWYQEVVLKAEMIEYYTEISGFFILRPSTMFIWNTIRNWFQERIEAMEVEEANFPMFLSSKSLEKEKDHVEGFAPELAWVTKAGDKDLEVPVAVRPTSEAVMYPYYSKWIRSHRDLPLRLNQWNSVVRWEAKQTTPFLRHREFLWQEGHTAHLTEELAGKEVLEILELYAGVYEELLAVPVVRGRKTEKEKFAGGYYTTTVEGYIPSNGRGIQGATSHCLGQNFSKMFDITVEDPTPLGEGEKAKHIHVWQNSWGLSTRVIGVMVMIHSDDKGLVLPPRISKLQAIIIPVGINKKTTPEDKSKHYDKLQELKDTLKKAGVRTDYDIRDGYTPAWKFNDWELRGVPLRLEYGPKDAAENVVSYARRDTGEKGTLPIADLSTSVPALLETIQKDLYTKAEASFRAHRLNITKWEDVVPALDSRNVVLIPHCLAEKCEDKIKDLTKSEEIDEGPGHEKVPSMGMKSLCIPFEQPEGIVKGETKCLNPECGAFAESWCMFGRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S9F6</accession>
    <name>A0A3D8S9F6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04478</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW82987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S9F6"/>
    <dbReference type="OrthoDB" id="6431331at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43689:SF8">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43689">
        <property type="entry name" value="HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="35"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW82987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="313" mass="35164" checksum="A84B2E903FE0E6E7" modified="2019-01-16" version="1">MDLPLTHEFHGWNIRYDLKQSKNTTESNRGQAQCVVFVHGTPWSSVVFKPIITALLAKGSYRILVYDLAGYGQSQEYNLDSNTTTSKAGFPGDTSVKFQAEALTELLRHVGLDGKGSNTAPSIIAHDIAGTIILRAHLLHGCDFATMMLAETNCVLPWGDGFYKLARSEPQAFIKLPPKIFEAVVRAVIQSACHDTNVLKTGWEDILVQPWISSDGVEAEDRQRSFVRQIAQADDRDISEMLDGDLYAHVRCDVKIVWGEQDQWIPRQKMEQLIKMLGNKVKETAFIPDAGHLIMLDQPGRFAIEVFDWLIRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SBA3</accession>
    <name>A0A3D8SBA3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_04942</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SBA3"/>
    <dbReference type="OrthoDB" id="4150765at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046707">
        <property type="entry name" value="DUF6780"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20571">
        <property type="entry name" value="DUF6780"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="3">
        <location>
            <begin position="209"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="40"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="615"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="623"/>
            <end position="638"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW83451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="701" mass="77284" checksum="C718423E15FEFF54" modified="2019-01-16" version="1">MRPLPGDDADRSRRSSLSQATPMAQPQMTYFLADEKTMEASALNSAPRQRESVKGHVIAENTEPIMSSPEPDVGKARHNWKNNLMQQMSADSDDGTTRSRSSSPQYSDLSRNASPSHERHPSQTNLSRPFTPSIFESPAPGSVMSSPRSRRESDAGSFMDDIASQAIMSSGEEGERDPPAMMDSGSAPQLVMPSIKMPSRRPFTDRGKNMGRLKVLIAGDSGIGKTSLIKAIVQTCEDIVHVDPISLPPISISPRRKSSKSRARSADLTNTAQITEVYASTRAYPAWWSDLDDGRVLRRRKSMGDSVLERNLCFVDTPGYGSATSCLETLNPVIDYVECQIRKVLTSELPESDVINLLSGSGGTQVDVVFYIIKQDIKPVDIEYLRRLAPLTNIIPVIGHADKLSQDQILALKSTIRSELGAVGIRPFYFGVSPDSGDHATAPWAVSTANARDMETMDASLLMSPDYVQPLVSSELAALVDQVFDQDNISWLRHSAAKKIIQWKNASSSTDRPQGLYRPLSLGSSVASSQLTTTTCATTSYALARITDHTQREERLAQIRLSNWAADLQRSIKNEQLRFEQVARNERAFWLTERLGECVQDGTIVPMSQARQMSFPGDSSALTKRDGRRHDKHYGPLDPHDPLGLLQLNADLKKRGILTLQVVSSFGIIGGLAFWISRGWQSGNGSLSWGVNWSEYCLIDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SBB3</accession>
    <name>A0A3D8SBB3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">pH-response transcription factor pacC/RIM101</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BP5796_04885</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the pacC/RIM101 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SBB3"/>
    <dbReference type="OrthoDB" id="6155966at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000993">
        <property type="entry name" value="pH-response transcription factor pacC/RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050806">
        <property type="entry name" value="pacC/RIM101"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47257">
        <property type="entry name" value="PH-RESPONSE TRANSCRIPTION FACTOR PACC/RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47257:SF1">
        <property type="entry name" value="PH-RESPONSE TRANSCRIPTION FACTOR PACC_RIM101"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0010">Activator</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="10" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="85"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="16">
        <location>
            <begin position="115"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="341"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="582"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="406"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="458"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00039490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDW83394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="620" mass="66901" checksum="1D85669F7EA06695" modified="2019-01-16" version="1">MSSNQDQQAQQVAAPAPQQAEVARAVVAADDSLACQWDKCSERCASAEALFVRSVLAIPPVPVFNPSEHICEKHVGRKSTNNLNLTCGWNSCRTTTVKRDHITSHIRVHVPLKPHKCDFCGKAFKRPQDLKKHVKTHADDSVLLRSPDQQHQGQNGGYRQGGKLVANLNQYAASAGYYDHTQMHPGSAPNYGHPQHNPHAGYYAPQQQASSYGPVYYPVNHGGDLGQHAAYDSRKRGYDALNDFFGDAKRRQIDPTSYAQVGQRLMALQGLPIHGGIQEYIPAGPAMVAVGGHGGHSTHMPQHHYALPPMPNLRTKNDLMNIDQFLEQMQSTVYENPNAAAAAGVQQPGSHYTHQGINFRQSHSPPQTQVHMPMGSSHMSSSHISAPMMHQSHSAQSDAGTPALTPASSAMSYTSGASPASYTSGHSPVTQHGMSPQSRHGSTSSAAYPSLPAVTHGYSPQSTTAPASQLGTNFDSDPRRRYSGGMLQRSAMSRSEMMDVSDDSTTPSPKLAPKESPKLDTIVKTEVSNNIDPALSGVSSPSVSSESGDSAADRAEAIWVGNIRVIEALRKLIAERLENKEYEEEADDVGMSGLDIKSPKPAPEKLPSSSQVVYPTLRVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SGL6</accession>
    <name>A0A3D8SGL6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_03771</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SGL6"/>
    <dbReference type="OrthoDB" id="10027823at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23520:SF5">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G04000)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="263"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="416"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="3">
        <location>
            <begin position="1"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW85446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="459" mass="49637" checksum="DA82BD7F5DEC339F" modified="2019-01-16" version="1">MAFHFHLKVLEEIGLCSLWSSTLDTKLLCMQRFARHFGYGGVALILVAYLDELSISKTRIGLFMTLTLVGDIIISFFLTAFADGLGRKATLALGALLMSASGVTFTLSGNHWVLLLAVIFGVISPSGNEIGPFRAIEESILAQLTPAAKRRDIYAWYSLTGSAAIACAMALSGWLVKHLREDLKWTAIGSYRVIFWGYAIVGIIKFLLVISLSKAVEANKEKEIPTAIDPETAPLLGDSSEDPERKSSTRALLPKISVESRAIILNLCLLFAVHSFASGLAPISWITFFFKDKFSLSEGKLGTIFFVTSAITAVSIPLASSIARRFGNIKTMVFTHLPSSIFLALMPIPSSLPLAATFLILRSSTVSMDSAPRTAFLAAIVLPHERTAVMGLLNVVRTSAQCIGPLIAGVLAGKNAIGWAFVAAGFLKATYDLGMLAVFAGHEMREERNAEDEDNAPER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SH18</accession>
    <name>A0A3D8SH18_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_03796</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the REI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SH18"/>
    <dbReference type="OrthoDB" id="19329at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040025">
        <property type="entry name" value="Znf622/Rei1/Reh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182:SF8">
        <property type="entry name" value="CYTOPLASMIC 60S SUBUNIT BIOGENESIS FACTOR ZNF622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182">
        <property type="entry name" value="ZINC FINGER PROTEIN 622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="24"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="10">
        <location>
            <begin position="89"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="163"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="311"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="460"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="312"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="343"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="497"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="523"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW85471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="541" mass="61032" checksum="254616BE96426477" modified="2019-01-16" version="1">MASIAASRVPAAQPDTASTHPYTCNTCQVAFRNSELQRGHMRTDWHRYNLKRRVTSLPPIAADVFTEKVLQAQASSTAAATKASYERNCDVCERTYFSENAYINHIGSAKHRAKMAQGGSGRHIDDASSVMSSTFSLGEPVAGNAEIDSEAEEEFNEVVEKIKQTNLKDAPPATRRPTRPHHSTEAETEDDESENTASSVTAAGDKEASPARCLFCNYDSPSVELNALHMERIHGMFIPERPYLVDLEGLIGSLHERIHQYHECLYCGKLKPTVFGLQTHMRDKGHCKIRFDTEDEQLEIGEFYDFTSTYSDVEEESDSEDELPGKKSSGGVKLGARRKITTEDEDEEMEDPEGWETDSSASSLDSADLTAVPLDSRAHQYEKLDKHPHHAHEDPRPHRNKDGFHSHAHKHAHAVFYSDYELHLPSGRTAGHRSLNKYYRQNLHSHPSPAERQEQFAIEAARGSDDEEEESQVARRERGRQLASRANGGIGMLGVTAEKRKEVKAEEKRSRKVEERERRKFQWGNNKQSNSQKHFRDPLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHJ0</accession>
    <name>A0A3D8SHJ0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12 16">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BP5796_04140</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="function">
        <text evidence="16">GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHJ0"/>
    <dbReference type="SMR" id="A0A3D8SHJ0"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003500">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045872">
        <property type="entry name" value="Arf1-5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 16" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 16" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 13 15" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="17" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 16" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 16" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 16" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 16" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00053326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00070396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU369003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDW85815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="183" mass="20922" checksum="C3B3F2135A2809FF" modified="2019-01-16" version="1">MGLTFSKLFDKLWGKKEMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKNIQFTVWDVGGQDKIRPLWRHYFQNTQGIIFVVDSNDRDRVVEAREELQRMLNEDELRDAILLVFANKQDLPNAMNAAEITDKLGLHSLRQRAWYIQSTCATSGDGLYEGLEWLASSLRKAGHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHV9</accession>
    <name>A0A3D8SHV9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_04208</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHV9"/>
    <dbReference type="OrthoDB" id="1747771at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016831">
        <property type="term" value="F:carboxy-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004507">
        <property type="entry name" value="UbiX-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43374:SF1">
        <property type="entry name" value="FLAVIN PRENYLTRANSFERASE PAD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW85883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="33966" checksum="21DDE834E8D8C32B" modified="2019-01-16" version="1">MAARTEKPFSENFSYKDAMDTLCDIIIRSNSIGTRHATPDFGSIQATVARIEHIRLKNIGHPMHSNIRQRCETCALDLHISFIIAWLCRPSLRGRHNLQSKTDVQVQLMEKCIENLLRSVRAFVQLHSLSIVASRSWAVIHNGLSSALLLGLLGETATNGEVRDLLGEILDILSRDPEEQGRQGQDLDLDFELSAPHTRAVTALRRLCNNDSNNFTHNNISNSGGINPKITDDQPQLAMNVERPDDSRGAASNYMDVTGFPGQDDIIQIGNSPLDMFNSIVWNPIDFGDSLLPDYSGSSLEPWMF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SJC1</accession>
    <name>A0A3D8SJC1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_04203</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SJC1"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="4">
        <location>
            <begin position="12"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW85878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="428" mass="47406" checksum="7145DAE3E92D5912" modified="2019-01-16" version="1">MPFQEPPGPSLRVAIIGGGPAGLGAAIEFAKLPFVDWNLYEKATSFREIGAGISIQPSTWRLLEVMGAAANLKPHDFYRPPENHRVQHRNGRTGELLQADEQTGVPQSQLHARTHRAKLQLAMLKEVDQNRVRLSSRLIKVDKMPSGKLLIEFQDGLIDEVDLLIGADGIRSVVRDFAFPNHSVRYIGRTSYRTVVSSDEIATVEGVPDAVTFWHGPSCWMYTCNLGDGKFEITTNTSEPSDEQEKVSWGQEATVEDNAKHFKDFCPVVKAIAALPKEVKQYALFAGPRLDSVIAHGSVALVGDASHPLSGAFGSGAGFALEDVYALTRTIAWAYKQDLNLQDGLELYDKIRGPHYRRLYGILDQNAEADVYIKAANLGFDETVDAVVGRKWTQKNNWVTKYDIQKDLKEVLEKETSIASHVQESSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SLW0</accession>
    <name>A0A3D8SLW0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02984</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SLW0"/>
    <dbReference type="OrthoDB" id="4805123at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017806674" evidence="1">
        <location>
            <begin position="22"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW87290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="151" mass="15868" checksum="C376C2B86590B3D9" modified="2019-01-16" version="1">MQFSSLLATALIPQLLSFVMASGCTQMWCQVSVCATDVNDAFNVASWGLTAVMGPDCADWNPDPPTDNGQGSCAAGLINYSGQFVIWRSWSANDQYSGSFAQWGNFLGATCSGGKVVSCDPKSGGYPDPSNGKCQIQRCVTDGSCANPAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SM22</accession>
    <name>A0A3D8SM22_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ammonium transporter-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_03020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ammonia transporter channel (TC 1.A.11.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SM22"/>
    <dbReference type="OrthoDB" id="534912at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008519">
        <property type="term" value="F:ammonium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3430.10">
        <property type="entry name" value="Ammonium transporter AmtB like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029020">
        <property type="entry name" value="Ammonium/urea_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001905">
        <property type="entry name" value="Ammonium_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024041">
        <property type="entry name" value="NH4_transpt_AmtB-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029">
        <property type="entry name" value="AMMONIUM TRANSPORTER MEP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43029:SF9">
        <property type="entry name" value="SIMILAR TO AMMONIUM PERMEASE, BUT NOT NORMALLY ACTIVE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00909">
        <property type="entry name" value="Ammonium_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111352">
        <property type="entry name" value="Ammonium transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="55"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Ammonium transporter AmtB-like" evidence="7">
        <location>
            <begin position="22"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW87326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="457" mass="49482" checksum="15CC98B59795FEEC" modified="2019-01-16" version="1">MPSSAAAAVVAAWEACDKTDTVFILVCSVFCWPIIPAVGLGYSGYSHKRNSMASFYPSLIAISCCTIQWFLVGYSLAYGEGSGVIGDLKYAFHRGVLADPVGTIPAILFSEFQLIFEATVCALSIGGFCERGRILPIIPFVFLWSTFVYCPMAHMVWSETGFLGEMGVLDFAGGTPVHICSGATATALSVYLSYPIARSRKSATRTPSHLRIHRPGGSWAQLLALVTIWNSWLAFDAGTTLSLNFKSVMAMCVTNLCAASGAMTWALLTYYESGKWSLDSTFMGAIAGLVLITPSAGFIDLPTSFFFGIGGALICRQALRIKFTDFARRWRWVDNGDTFATHCIGGFVGTIATGLFARKDVAYYDGFTEIEGGVFFDGNVKQVGIQILEAVVGFTWSFVASYVIVALIDCVPGLEVLAVNDDVMSGMDEAQMEESLAETKWESEEEYHPLTNGVALE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMG2</accession>
    <name>A0A3D8SMG2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">Uracil-DNA glycosylase</fullName>
            <shortName evidence="7">UDG</shortName>
            <ecNumber evidence="7 9">3.2.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="primary">UNG1</name>
        <name evidence="12" type="ORF">BP5796_03207</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7 9">Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 9">
            <text>Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.</text>
            <dbReference type="EC" id="3.2.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Mitochondrion</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7 9">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.2.27" evidence="7 9"/>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SMG2"/>
    <dbReference type="OrthoDB" id="10031947at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097510">
        <property type="term" value="P:base-excision repair, AP site formation via deaminated base removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.470.10:FF:000007">
        <property type="entry name" value="Uracil-DNA glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00148">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018085">
        <property type="entry name" value="Ura-DNA_Glyclase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003588">
        <property type="entry name" value="PRK05254.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003589">
        <property type="entry name" value="PRK05254.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003592">
        <property type="entry name" value="PRK05254.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00628">
        <property type="entry name" value="ung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264:SF0">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00130">
        <property type="entry name" value="U_DNA_GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5 7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 7 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="11">
        <location>
            <begin position="127"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="34"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7 8">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW87513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="321" mass="35591" checksum="F8AA196AC9D2631C" modified="2019-01-16" version="1">MSSLKRKAGEDSSPSEIKKPKANASITSFFGPPKTVSSSTKATGTSTATIDAAPAKFDKEKWVAKLTAEQKELLKLEIDTLHESWLSQLKDEITGKDFLELKKFLKRELDSGKKVFPPMEDVYSWSRHTPLNTVKAVIIGQDPYHNVNQAHGLSFSVRPPTPAPPSLKNIYKALEKDYPSTSATPFVPPPKNGGLLTPWADRGVLLLNTCLTVRAHEANSHANRGWEKFTQKVIDIVEKRRSRGVVFLAWGSPAGKRVQKVNKQRHLVLQSVHPSPLSAMRGFFDCGHFKKANAWLVDEGRYGKDGAIDWSLNVKPEEAGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMH2</accession>
    <name>A0A3D8SMH2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03217</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SMH2"/>
    <dbReference type="OrthoDB" id="2288928at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="44"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW87523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="651" mass="73156" checksum="2B26DE97343E8DA8" modified="2019-01-16" version="1">MGSVYNSYPLKTPRTVRFLIPKKREGELLSYQFVVESLDQNVRYAALSYVWGDQAKAGSLMLEGEHKGVTRNLLDALKKLDKTLGQDDSCGSEPLPLWIDQLCINQDDLDERGSQVALMGDIYSCAMRVYVCLGDSNTAADAVHVVTNVCDRIRLDAAQYFTIDDIPWISTDELISYNQLNWSAFKEMMLVSWFSRAWVVQEVGLAKHAIVLYGDYHFEWQSLMTVLGWLSYPGSRLRQIHKLSGWTVHQVWVSFDPKRRIQTNHFPAYNFLDLLSHAASRYKATDARDYIFSLLGHPSSKLPLLRAEQQSPLTEPNYTASVGGVFTQFAIAWLERSRKAYLFSCVNHKQLPPLHAGYSSSHTNRLEIPSWCPRWDYLPLGGSRLDVETDKRWYNASASTEFGFRILPENRLEVRAILYDTISETFPALKDLPIPVVVDTKSTRDSICSVSEIETALKLGLLCGRILESMGRQSSSGALKEQSIQDAIFVFASTVHAGDWQGEDVSLHKARQLANFKASLVQAQISYALVEEMAPSFEIPFNLLRACCEWLECSSSSVDDPCGFLQVAETMMDSRTLFLTDQGHIGLGPEIIMPGDICCVISGANAPYIVRPFGSATNLLVGECYVQDIMHGEVIKDYGKSGYEWCDIVLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SN88</accession>
    <name>A0A3D8SN88_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03464</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SN88"/>
    <dbReference type="OrthoDB" id="5226533at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW87770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="101" mass="10674" checksum="3643EED1FC9841D2" modified="2019-01-16" version="1">MASQTASDILALRARSQPMQFLSLAPTTSSSYPATPAMKSPSLAAEKQEPALVTEANEAKIRRSSSSASSNVGGMRFLKLGPVHFGADYGNEGDWSEVVVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SNF5</accession>
    <name>A0A3D8SNF5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03516</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SNF5"/>
    <dbReference type="OrthoDB" id="9971601at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36142">
        <property type="entry name" value="METALLO-HYDROLASE/OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36142:SF2">
        <property type="entry name" value="METALLO-HYDROLASE_OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW87822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="419" mass="46131" checksum="000282A255FB10D3" modified="2019-01-16" version="1">MALVRSPPLFIQSLASGSSHATYDEAPPSPSEQLFHDLHTSITASISSTPQRRPILTHLNADTTWLLSIPYPQEQRTHGEPSSETKQTRRSPRAVKNTRIVREAKIVTPAKRKRSSSEEEGDKKKKYFHILIDPWLKGSQSDVAAFFSQQWHATPSAVQTIEEVEQCIWELEAVAAGQDPPSARWEKSASALDCVAISHEFTDHMHEATLREIAPSVPIFATPKARGIIASWGHFNQVLEIERFGGDWRRGALHGAGVLPRWLSISRLAFPGKDLLYYHSAIMIAFCGSLNPSVGDAEAVIYTPHGISPPVAEPVGKAHPKIKTLALLHGLHDITLGAQLNMGAHNGLKIQRALGAHYWIGTHDEVKKGGGLISWWLKRKVVTLEDALKIEVFGGGKEGKEELAVRFVDLGNGESLILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SNF7</accession>
    <name>A0A3D8SNF7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_03531</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SNF7"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW87837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="61" mass="6781" checksum="58BF7ABBE7FE4096" modified="2019-01-16" version="1">MAPQAYSLTLMPPCGPSDLNPSIIYLHMVIPTPADFRIDVRRNVAGVYLQLLEAQEVINNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SNH8</accession>
    <name>A0A3D8SNH8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_03435</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SNH8"/>
    <dbReference type="OrthoDB" id="10253390at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021829">
        <property type="entry name" value="DUF3419"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47473">
        <property type="entry name" value="BTA1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47473:SF1">
        <property type="entry name" value="METHYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11899">
        <property type="entry name" value="DUF3419"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW87741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="835" mass="93721" checksum="BC8B3E3BDBE71D71" modified="2019-01-16" version="1">MASLIPSILPEDPQTQIYIAGATIVLLVGVVFAVKSPQPKPKEDEENPGTFASFVRFFYGCFLKPHSGDAENGQQDALESFYKAQAGVYDATRKKLLRGREDMLGLVAAQLVHKAASEQSQEKKRIWVDIGGGTGWNIEAMSAYVSVPEFFSSVYLVDFSPSLCEVARKRFARLGWDNVKVVCQDARTFRLEDHEGADDKTVGFAKSPLDYLNDDQSSVGGANLITMSYSLSMIPDFYSVIDSLANLLAPTGTIGVVDFYVQSIVDLSFRNYTGGVINRHVNWFGRIFWRAWFDVDRVGLEASRRDYLEYRFGTVLSADSRNTLLGSIPYYVWLGCPKKPVSSLNTPNYPHEIVERLDAAATESPYLSPINHTKSLSKNVEKATPPEIRSKAFDAAVINLSSNLPLPSFFYQNHHWRIHYDDQLKKHTQFNNEYIYAFTWEDSRVDERLLKLTNKDVVLAITSAGDNILSYALNSPARIHAVDLNPSQNHLLELKVAAFTALPYADFWKLFGEGKHPQFRELLISRLSPHLSSRALQYWLQNTTIFTSTKSRGLYETGGSRHAIRVVRLLTTVLGFKKEVKALLASKTLNEQREIWDKKIRPLIMSRLLSYFVVSSEKFLWAALGVPSNQLAMLVADEESSNRGQAVWNYMTSTLDPVIATSIIGEDNPYYLICLQSSYTQRCHPDYLKPKSHQKLSRPGAFDGLRIHTDEINEVVSRLTPGTLTVAVVMDSMDWFDPQAPAAATQITKLNRALKLGGRVMLRSAALTPWYIETFESLGFQAKRVGVRIGGACIDRVNMYASCYILTKLENVTPDTPIAISTGRQNSVELEKLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SNL1</accession>
    <name>A0A3D8SNL1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyclin-like f-box protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_03465</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SNL1"/>
    <dbReference type="OrthoDB" id="4540290at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017692977" description="Cyclin-like f-box protein" evidence="2">
        <location>
            <begin position="27"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW87771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="35171" checksum="98821F73473D2F84" modified="2019-01-16" version="1">MAFNQESWLRVFSFLLCLVFAFPVNALPKKGTSTSSNGSSGTTKAAAASSSGGITKATDGSMILDKTVTINGLSIRYKVSGPANMFTAASGVTGATSAANATGTAGLNVLLHGDGGTSFFDFPNQAVQNNLMGVAVLAPNTNRFWGGGSGLQRTDGVAHAAAVNSLIQNQLPKDIAFDKTNVNFMGVSGGSLLLSGFFVPTFGATYKSATLLSCGALTPQVPVVDANTLVTTTKIHFQSTSDELALLQPAIPAAIQAYEKLATAAGMSATQIGALQTVNNSPNGGGHCGFDQKAFVSGVQLLANNYANIMGANASGQVTGITGSVLKTVVGNENVVFTSAGQAQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SNR9</accession>
    <name>A0A3D8SNR9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sialidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03659</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SNR9"/>
    <dbReference type="OrthoDB" id="2739686at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036278">
        <property type="entry name" value="Sialidase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38792">
        <property type="entry name" value="BNR/ASP-BOX REPEAT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G06430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38792:SF3">
        <property type="entry name" value="BNR_ASP-BOX REPEAT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G06430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50939">
        <property type="entry name" value="Sialidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017727783" description="Sialidase domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW87965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="368" mass="39269" checksum="9CFD32DB3E9019CB" modified="2019-01-16" version="1">MSKLHFRFLPVLLLLFCARLAFASPLLASHRNLRRAGNDPTVSGAAVSMNGGTYPRATRLADGSILAAHTVISGDENIISILRSTNNGDSWDDWGTVEQGIGDIDNPFLVQLPSGRVLCAFRNHSLDGTVYTVFRITICYSDDNGVTWAYLSQPASDPGPGPANGLWEPFMRISSISSNTLQLYYSRVNAEDDQDSLMRTSTDGGATWSLAATITGDGVTARDGMTGVAEFPALSGNLVIIFESKDTSAGGTGLFTVNSCTSSDDGVTWSTSRNRVYTPTGTSNNAGAPQIINIDGASFMTDEDTSENDWPHGADAKILTSTDGINWSEKTTVMPVQSYWPGLLALDDTSFLLMADHGGAQSQLVTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXD5</accession>
    <name>A0A3D8SXD5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cell surface protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW90934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SXD5"/>
    <dbReference type="OrthoDB" id="5310497at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021476">
        <property type="entry name" value="Egh16-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618:SF1">
        <property type="entry name" value="SECRETED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34618">
        <property type="entry name" value="SURFACE PROTEIN MAS1, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11327">
        <property type="entry name" value="Egh16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017671951" description="Cell surface protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW90934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="28145" checksum="9566C9B98B5D5728" modified="2019-01-16" version="1">MQYSSVLLCAAFAVTSVYSHGVVTEAQGANGVNMPALSVIDNTPRDCPTPFCGAEADTSILVPGEAATMPLGRNSKGAVVAAPMIMNYMGGTANNTARDLHEMGTLYRRAAAATTAGVATPAGTKEQGVAASAGKGATAGLPTTDDQGVISMTIHQVNQDGAGPFMAMVDATSGGTDANAFKSAVMTQNVPGIGVAGISTASVMDFPAKMQMPAGMTCSGTVGSATNVCVAKMSNGPPQYFGGSIAFTQSPAAKKRAIEYNMKMRRDAKARRGQSDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYB7</accession>
    <name>A0A3D8SYB7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Multiprotein-bridging factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_02414</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Transcriptional coactivator that stimulates GCN4-dependent transcriptional activity by bridging the DNA-binding region of GCN4 and TBP (SPT15), thereby recruiting TBP to GCN4-bound promoters. Involved in induction of the ribosome quality control (RQC) pathway; a pathway that degrades nascent peptide chains during problematic translation. Required to prevent stalled ribosomes from frameshifting.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MBF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYB7"/>
    <dbReference type="OrthoDB" id="10253401at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013729">
        <property type="entry name" value="MBF1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245:SF15">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08523">
        <property type="entry name" value="MBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="8">
        <location>
            <begin position="87"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW91249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="155" mass="16527" checksum="C99F12636059BE91" modified="2019-01-16" version="1">MSEDWESVTKIGSKTRGGGAARETVVRGKSALNAAQRSGAVIGTEKKYGAGNSSSKPGVEGQHLTKVDRSDDIVKPNTIGKEVGSVISEQRQKMEPKMTQKDLATKCNTTQSIVADFERGTAAPDQKILANMERVLGVKLRGSDIGAPRFGPKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYD6</accession>
    <name>A0A3D8SYD6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 17">Delta-aminolevulinic acid dehydratase</fullName>
            <ecNumber evidence="5 17">4.2.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BP5796_02500</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 17">
            <text>2 5-aminolevulinate = porphobilinogen + 2 H2O + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24064"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58126"/>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <dbReference type="EC" id="4.2.1.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 1/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 17">Homooctamer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 18">Belongs to the ALAD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.24" evidence="5 17"/>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYD6"/>
    <dbReference type="OrthoDB" id="1530at2759"/>
    <dbReference type="UniPathway" id="UPA00251">
        <property type="reaction ID" value="UER00318"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004655">
        <property type="term" value="F:porphobilinogen synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006782">
        <property type="term" value="P:protoporphyrinogen IX biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd04824">
        <property type="entry name" value="eu_ALAD_PBGS_cysteine_rich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000048">
        <property type="entry name" value="Delta-aminolevulinic acid dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001731">
        <property type="entry name" value="ALAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030656">
        <property type="entry name" value="ALAD_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006762">
        <property type="entry name" value="PRK09283.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11458:SF0">
        <property type="entry name" value="DELTA-AMINOLEVULINIC ACID DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00490">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001415">
        <property type="entry name" value="Porphbilin_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00144">
        <property type="entry name" value="DALDHYDRTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01004">
        <property type="entry name" value="ALAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00169">
        <property type="entry name" value="D_ALA_DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0350">Heme biosynthesis</keyword>
    <keyword evidence="10 17" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11 17" id="KW-0627">Porphyrin biosynthesis</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="19">
        <location>
            <begin position="17"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="14">
        <location>
            <position position="255"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate" evidence="14">
        <location>
            <position position="308"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="265"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>5-aminolevulinate</name>
            <dbReference type="ChEBI" id="CHEBI:356416"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025628"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001415-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU004161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RDW91335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="385" mass="41747" checksum="D632739CF616723F" modified="2019-01-16" version="1">MSFSSLVQDLSFRDNANERRAVNRGNSSASTMDDRRSQVSRAMSYTSTTATSVSISGDISSQLHGGYCHPLARSWQAERQLTKSMLIFPLFVSDIDDEEVSIPSLPDQHRRGINKLVPYLEPLIRKGLKSVILFGVPMAAGAKDALGTAADDPKGPVIAAIRLLRQRFPQLFIVADVCLCEYTSHGHCGILKDDGSLNNALSVDRISDVAIAYAQAGAHCVAPSDMNDGRIRAIKLKLIEEGIAHRVVLMSYAAKFSGCLYGPFRDAAGSVPSFGDRKCYQLPPGGRGLARRAIRRDIDEGADVIMVKPASQYLDIISDAKDIGRDMPIAAYQVSGEFAMIHAGAKAGVFDLKTMALESTEGILRAGATIVVSYFTPQFLDWLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYG5</accession>
    <name>A0A3D8SYG5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dystroglycan-type cadherin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_02376</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYG5"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006644">
        <property type="entry name" value="Cadg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015919">
        <property type="entry name" value="Cadherin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05345">
        <property type="entry name" value="He_PIG"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00736">
        <property type="entry name" value="CADG"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49313">
        <property type="entry name" value="Cadherin-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017759833" description="Dystroglycan-type cadherin-like domain-containing protein" evidence="3">
        <location>
            <begin position="20"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Dystroglycan-type cadherin-like" evidence="4">
        <location>
            <begin position="22"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Dystroglycan-type cadherin-like" evidence="4">
        <location>
            <begin position="141"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Dystroglycan-type cadherin-like" evidence="4">
        <location>
            <begin position="331"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="555"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="713"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="918"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="957"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1057"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="576"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="627"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="777"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="959"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1093"/>
            <end position="1103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW91211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1112" mass="119808" checksum="4E10A977EC0A5F18" modified="2019-01-16" version="1">MAPRRVFSTIALCAGYACATPTIDYPINAQVPPVARLSEPFSYTFSASTFSSASTITYTLTSGPTWLSLDSNTRTLSGTPSSSDVGPGTVTGVPIELTATDNTGAVTSNATLVISTNPAPTVNIPAASQLISFGSFSAPSTLLYHPSTAFSFQFDAETFLDNATGLGYYAVSLNNTPLPSWVEFDQETLSFSGRTPDYESLIQPPQIFGFRIVASDVVGFLGNSITFEIEVGVHLLAFTSEEFYINATIGSNISFTGLANSLLLDGLTASKSSLTSVSSQTPSWLTFDNSSFALSGEVPKGAIPSNITISATDIYGDVANTTIIIAPPSELFNTQIEGFNATAGKWFSTNLATYLQNSSDIEMTAQFTPVTAWLNFNTQNFTLSGQVPSSFTASKINIALTATSKSTMQEAAQSFGLAILAGTDQATSTKSTASSSTAHSTTTASASSTRVAGAIASEGLSRGVIAAIVVPIVLTFLALLACLCCCLARRRKAKRPTSPSKSEISAPTESKMQPQDEVQVRAISPIPHVRPPKKLELDTSSFLLIRNSFRNSRGFTNSPRGSIKRNPDGTLRRSQTEINSLSVNRDSNSSGNMFRSLSENALSKTESSWRSTQGSSSVQESAYPVIGSRRSSSNKLSSGNNYSVSRHYSNYSRKGHARRSTRMGSGSISYLRDSNMSLRPTTGNSILNLRDSNFSLAPLDDFSVLSKSSSVQQTPEFAYATGSKKREIDPTKRYSRWIPSMERRRSGIGHGVQNSYSSSSGGYAPGKRASIGHGQEWVSTSESSGHPQQAPLTRNSSGWHTASDGSGSNEKNRRGSSGSNMTENTDLLYPGDPRNMNIKQVARSPVVPPSIIYSESSRGSRPVSRRTTGSTPFFGGGSSVRTSKKKQRQVPEYLYDDSPTVPEEEAIASRRALERSIMQSLRRQSNEPRDSFGISYGDAREGTERLRSYIESCRGRTGTLGSLNSNLSRDSRFESAEPSTYSRERGASGNYPEEAESRGKEMAGAEWEDYLPEAYSEGSWAEHASPRRDSRGNIIEYGVDESPNIEEAATQAAVRPQFLSGSSDSNKMPEIAPNARVLRGSFRRPTSDDSKGQRITSQSVSSIEQEDYRAYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYG9</accession>
    <name>A0A3D8SYG9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative major myo-inositol transporter iolT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_02474</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYG9"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="196"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="349"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="24"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW91309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="523" mass="57688" checksum="58F8187FDA2A0A21" modified="2019-01-16" version="1">MPNPPSRMKDDTSLFPVFSKKHEIVAFSSTAIALYGYDQGMMSLINTNRNYLQTMKISEESPIVGIIVSVYYLGCAVGSVVASWLADKRGRKPSIFACLATTSFGNILMFISGLSMNGSSAWDGYAIVFMLLGRIIMGLGVGGIDAVIPVYSSELASDGARGRALAQEFQMNIFGLLMAFSINLGVTIGLGKDNQWAWRLPIIIMQIFPVLLMSLISRLPETPRWFMSKERRTDAGKALESIYGKQGAKSKLKELDEIQDNENDEKVGYKDMLLPGGSQFHPTMVTIMGQINQALTGYGAVSVYGPQIFELLGFSVRDAEYLTLGNYFFYFGMMTLAWMSIDVLGRRRLMLWGSMGLAGSFALLTLFGGLSYDFPNIPSLAVGIPGSIILYLATAIFGIGWLATVWLIPTEIYPSTARAQGSAISVIVWGLANFTVTLLAPIGFNNLKYWLFLVFAATNTFAGWWTWKYSPESGGRSFEENQEFFISAVNDKSWSVKKVDGGKFLRMPGNDIDTEREPLLRST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYR3</accession>
    <name>A0A3D8SYR3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HhH-GPD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_02564</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkylbase DNA glycosidase AlkA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYR3"/>
    <dbReference type="OrthoDB" id="415889at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032131">
        <property type="term" value="F:alkylated DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043916">
        <property type="term" value="F:DNA-7-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000004">
        <property type="entry name" value="DNA-3-methyladenine glycosylase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051912">
        <property type="entry name" value="Alkylbase_DNA_Glycosylase/TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003:SF5">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="5">
        <location>
            <begin position="188"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="59"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW91399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="368" mass="40279" checksum="B39FF83F29EB888A" modified="2019-01-16" version="1">MATRRSARLTSAVEELAGPPVLPKASQAPKAPVAKKRKAITSEVPELLPKIDYALPTTPKRKKVAPAPPPFTPTPSAVGLMSDPIHPAPNHPKSIRNRLAAPDATNAPLLSPETSRLLASKPLDEVSPSKVSNVKTTTGNILEEACAHLIKIEPKLKPVIEKHHCKIFSPQGLAETVDPFMALTSGIISQQVSGAAAKSIKAKFVALFNTDIPEPENHVFPIPSLVAEKSIEVLRTAGLSQRKAEYIKGLAEKFVSGELSTSMLFSATYEEVFDELIKVRGLGAWSVEMFACFSLKRMDVFSTGDLGIQRGMACMVGRDVSKAKSSGKGKWKYMSEKEMEEIAEKFKPYRQECLYVVYVEIWGRNHRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T018</accession>
    <name>A0A3D8T018_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Reticulon-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_01290</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Endoplasmic reticulum membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T018"/>
    <dbReference type="OrthoDB" id="567788at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003388">
        <property type="entry name" value="Reticulon"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02453">
        <property type="entry name" value="Reticulon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50845">
        <property type="entry name" value="RETICULON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="249"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="Reticulon" evidence="8">
        <location>
            <begin position="122"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="74"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="324"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="84"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="349"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW91896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="378" mass="40893" checksum="17FA344614479C82" modified="2019-01-16" version="1">MSSDLASNDTGATILPSIETPEPSTNGSSLAGMKQTVVDSKYNSSSKLPHHQLTECSDASAAINAVQNHPVTQSVANGPVATSVRDQSAKTSSEFSNLANSRTTPSRPTATGQPLTHYHSFFGTLLSWNNPRASGIAYLSTVLFIFAARYLNILRYAFKLTWMTLGVTVLAEVAGKTLFSAGFTSQFRPRKYYTVPKQTLDMMLGDVHELINFFVIESQRIVFAENVAASVAAFFGSFLSYYLIKVVPLWGMALISTSVLFLGPLVYKTNKELIDHHVENASNVINQQTQQVKQLASHHAARATEFTKQSVGDYSAKAQEMVANARGRSSSPVATKSAPVKTEPAPAYKSEDFPAAPKEEFKSEAAPSVGEQEPLIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0J9</accession>
    <name>A0A3D8T0J9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribose 5-phosphate isomerase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_01345</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LacAB/RpiB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0J9"/>
    <dbReference type="OrthoDB" id="2106730at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1400.10:FF:000004">
        <property type="entry name" value="Ribose 5-phosphate isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1400.10">
        <property type="entry name" value="Sugar-phosphate isomerase, RpiB/LacA/LacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011860">
        <property type="entry name" value="Rib-5-P_Isoase_Actino"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003500">
        <property type="entry name" value="RpiB_LacA_LacB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036569">
        <property type="entry name" value="RpiB_LacA_LacB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051812">
        <property type="entry name" value="SPI_LacAB/RpiB"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004051">
        <property type="entry name" value="PRK05571.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02133">
        <property type="entry name" value="RPI_actino"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00689">
        <property type="entry name" value="rpiB_lacA_lacB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43732:SF1">
        <property type="entry name" value="RIBOSE 5-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43732">
        <property type="entry name" value="RIBOSE 5-PHOSPHATE ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02502">
        <property type="entry name" value="LacAB_rpiB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005384">
        <property type="entry name" value="RpiB_LacA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89623">
        <property type="entry name" value="Ribose/Galactose isomerase RpiB/AlsB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017677922" description="Ribose 5-phosphate isomerase" evidence="3">
        <location>
            <begin position="20"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW91951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="164" mass="17255" checksum="5D68D1B99E318198" modified="2019-01-16" version="1">MGSKPGLRIVLTCVILTAGFDYKAQLTRDLESSSLVSSVVDVGPHSASDKKAYPHFAVDAAKMVASGEADRALLICGTGLGVAISANKVTGVRAVTAHDSFSVERAILSNDAQVLCLGQRVIGIELARKLVKEWLGYTFDPNSASASKVKAINDYDLANQTVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0P8</accession>
    <name>A0A3D8T0P8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02743</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0P8"/>
    <dbReference type="OrthoDB" id="4187154at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="627"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="636" mass="70246" checksum="AC75A3D0CBB2534E" modified="2019-01-16" version="1">MSLRAVELDPLHLFSLHEKLKLSVQAAADIDCPCGNLLDLSPDEFLVALTSMTMWVARGSRCCIEICLTVDGEGLLGHYRSTVMESLCNCIREAPFWSQLSLSVSLRESCMDEVPEANEPGIMLNVDHKLHLSELDGDFGSSLGFLSEFRPPEGILCPKFAKLRMNLAFETMTVSRTTKRAKLTGVASETVSRSPQEHIAKSRTDDTALDHLEEVVKRIHHNLSSSILTSFGEPRTTNLSFMDLDWSPKDAVSEDNIDDENTEKVFPQCELGNSLFEQYSSIPAAYSQSSGSAKCDLAEADVSITTLNISKACQLAETAMRLVISGFRRGQRHMADISIQHPWPSTALCAISPSLWCPGFKLASGSQEKCMDQNAQFLPSISQAICVSWTQNAQSPSLRQKLLQLADSVPSHSNENNSGLGATGATDRLTSVVQSRLWTMMQRKLYDPSAARHLRLSVHRDWQAEPEAADFEDLLQNDTASQDADTCLEDEEDSASSVFHDVLADFEYDEEVDLLAAQEEKERQSTERETDIMLVDEQNMDHEDDENDILFGQINWHVRDTGIGAPDKIGDCMLLSGGSRDSMYVNVSSSLTNEDTYGATMASSSSMAEGIAEDETLASEQCSEDNLWSDEGEMLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1C5</accession>
    <name>A0A3D8T1C5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pyridoxamine 5'-phosphate oxidase putative domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_01202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1C5"/>
    <dbReference type="OrthoDB" id="539398at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39336:SF3">
        <property type="entry name" value="PYRIDOXAMINE PHOSPHATE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39336">
        <property type="entry name" value="PYRIDOXAMINE PHOSPHATE OXIDASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G11440)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="262" mass="29054" checksum="DEAAC8C3110C8FB4" modified="2019-01-16" version="1">MGAFYETIPPSLYRWILEQKVFWIASAPLSSLGHINVSPKGGQYFGLVDPKTFWYLDLTGSGVETLSHLHEPGNGRITVLLNAFEGPPQIVRLWGHGEVLEYGTPAFASFIDTHKVNAIDGTRAVVLVHIHQVGSSCGFSMPCYDFKEFRPTLNEFFEKRVASEVAGNKKDGIERYWAFKNSESMDGLPGLRRGVETAQREQVKPIKKMVGPFAKMLSSAQARSPTSVPVWYLVVVALAGFVTGVFAMLFLTRKEGLFTMCA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T321</accession>
    <name>A0A3D8T321_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DJ-1/PfpI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_01792</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T321"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03139">
        <property type="entry name" value="GATase1_PfpI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF15">
        <property type="entry name" value="THIJ_PFPI FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_5G14240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="domain" description="DJ-1/PfpI" evidence="2">
        <location>
            <begin position="11"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW92398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="233" mass="24960" checksum="0532C28DA8990F4F" modified="2019-01-16" version="1">MTSVELKPVNVGFVLFPGFQALDAFGPLDALNILSTKTKINLSILAATLDPVSTRLPGEQQNPFGSNCAQSVVPTHTFDNAPDLDVLFIPGGIGRREPDTVDQVSKLLVRLYPSLQSVITICTGAAIAAIAGILDGKKATTNKKSWSLVTPLGPKTHWVANARWVRDGKVWTGAGVSAGIDVTLAWIEEVWGEDMATDVTTVMEYNRAKDPSQDPFAPLYSITDVINGEVQPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T6Y5</accession>
    <name>A0A3D8T6Y5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptide chain release factor N(5)-glutamine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.297</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_00080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[peptide chain release factor] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42896"/>
            <dbReference type="Rhea" id="RHEA-COMP:10271"/>
            <dbReference type="Rhea" id="RHEA-COMP:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
            <dbReference type="EC" id="2.1.1.297"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.297" evidence="1"/>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T6Y5"/>
    <dbReference type="OrthoDB" id="269872at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102559">
        <property type="term" value="F:peptide chain release factor N(5)-glutamine methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004556">
        <property type="entry name" value="HemK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050320">
        <property type="entry name" value="N5-glutamine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00536">
        <property type="entry name" value="hemK_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895">
        <property type="entry name" value="HEMK METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18895:SF74">
        <property type="entry name" value="MTRF1L RELEASE FACTOR GLUTAMINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase small" evidence="7">
        <location>
            <begin position="129"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW94317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="386" mass="43166" checksum="49B3A6FD7CB4ACD9" modified="2019-01-16" version="1">MPRLSNAVLLRAYGISPLLPLVLRGCRELPSAINELRWLREHVRSENKSRDTRLLSRKLLELCRRRAKGEPLQYLLGTQPFGELEIKCRPGVLIPRPETEAYTTHVAEILLSQHGKGPLEPKTNQNSLESLNVVDFCTGTGCIALLTNSLLSKRFPRVNVIGVDISSHALALANENLAHNLKDLNADKASSRISFEAGNLFSDLKHPSFHSFSPDVVISNPPYISEKGFNTETTRSVRTWEPKLALVPAITLERPDCAPEDIFYQELLETYSTQKSRMMLLEIGDSDQAMRVAKLAVRIGGDCKVQIWRDWPDQEAPPEAPSMVRIEVQDGSKGSLIHRDILVKGLGKARSVLVLWGSYIDLLHPPSADGTDPPESLDWETTWEKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7A0</accession>
    <name>A0A3D8T7A0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aminomethyltransferase</fullName>
            <ecNumber evidence="4">2.1.2.10</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glycine cleavage system T protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_00173</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N(6)-[(R)-S(8)-aminomethyldihydrolipoyl]-L-lysyl-[protein] + (6S)-5,6,7,8-tetrahydrofolate = N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16945"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:10492"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="ChEBI" id="CHEBI:83143"/>
            <dbReference type="EC" id="2.1.2.10"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">The glycine cleavage system is composed of four proteins: P, T, L and H.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GcvT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.10" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7A0"/>
    <dbReference type="OrthoDB" id="10263536at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004047">
        <property type="term" value="F:aminomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008483">
        <property type="term" value="F:transaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.110:FF:000002">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1400:FF:000001">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1250.10:FF:000002">
        <property type="entry name" value="Aminomethyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.110">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1400">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1250.10">
        <property type="entry name" value="Aminomethyltransferase fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.120">
        <property type="entry name" value="Probable tRNA modification gtpase trme, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028896">
        <property type="entry name" value="GcvT/YgfZ/DmdA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013977">
        <property type="entry name" value="GcvT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006222">
        <property type="entry name" value="GCVT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027266">
        <property type="entry name" value="TrmE/GcvT-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43757:SF2">
        <property type="entry name" value="AMINOMETHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01571">
        <property type="entry name" value="GCV_T"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08669">
        <property type="entry name" value="GCV_T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103025">
        <property type="entry name" value="Folate-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="GCVT N-terminal" evidence="12">
        <location>
            <begin position="87"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="GCVT N-terminal" evidence="12">
        <location>
            <begin position="375"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="Aminomethyltransferase C-terminal" evidence="13">
        <location>
            <begin position="453"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="328"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="331"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW94410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="540" mass="58563" checksum="CF44B41562CBF3CF" modified="2019-01-16" version="1">MKRVRTVTSIADALTANRFAARSTRQLSTASFSLNRHTTGPSKVIASRRPLVASTYLQKAPITVRYESTTVGSKENVEDNGLDITPLYEMHELEGAKFVPFGGYEMPVSYEGQSITDSHKFTRSHCSIFDVSHMVQHKFSGPGVTAFLQTITPASLTTLAPHHSTLSAFLWPITGGIVDDTIITRLGPEDFYIVTNAGCREKDLKYLEDQLAQFLQNGGEAVNWEVMEDWGLIAVQGPLSEEILQSVLEDPDKTNLKELYFGQSKFLEIKTDIGPKLCLVSRGGYTGEDGFEISIDPDDTVAVTVSILEAGDPHYSAEETDEIDGLEETSAAKNSSTGSTFDSKIEPSKAGESDEAAAGSAIDRFLEEGKASEKEEGADDQVKLAGLAARDSLRLEAGMCLYGHDLDDTTTPVEASLSWIIGKDRRAEGGFHGAEVILKQLIPKSKGGLGVERRRVGFIVQGAPAREGAEIVDDKGEKIGNITSGCPSPSLGKFIAMGYIKDGLHKSGTEVTVMIRGKPRKATVTKMPFVPSKYWKQPSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7G6</accession>
    <name>A0A3D8T7G6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_00259</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7G6"/>
    <dbReference type="OrthoDB" id="2019504at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010301">
        <property type="entry name" value="RRP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026">
        <property type="entry name" value="NNP-1 PROTEIN NOVEL NUCLEAR PROTEIN 1 NOP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05997">
        <property type="entry name" value="Nop52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="193"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="224"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW94496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="235" mass="27226" checksum="1BC3F968111DBA41" modified="2019-01-16" version="1">MATDIQQTPFVKQLAANDRPTRDKALQSLRTYLSGRRELPALELMKLWKGLFYCMWMSDRPRTQQQLANDLAALVSVLPSATVIPFLRAFWQTMQREWTNIDVLRMEKFLLLTRRYLGATFSILKEGKWEEELVKEHMALLEEIPCNIEDMRIPNGMRFHVIDIYIDELERVSAIEDEEASLDLLLEPLKKLSKSSPTKPVRTKCKEALGDERLPGNEKSEPEKPEDDGWGGFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7G9</accession>
    <name>A0A3D8T7G9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_00144</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7G9"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF102">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW94381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="38306" checksum="1700B3717D4C52B7" modified="2019-01-16" version="1">MEQPDFIEVDDTPGDKNASQLEHGISISTGTENEERTYHTLNEGKYMLPNDEVCKATRSNLVAKAEKAKSLDGSDGHQRSDLQHRVITYALDDKLQLAPIPDSFSGNVLDLGTGSGIWATEFASRYPSSTVLGIDLSPTNPSFIPQNCSFRIEDYEEEWKHSAPFSFIHGRALISCLKNPPQTFATAYQNLAPGGWLEIQDIIWPFKSQDESLAEKGKPLLQWCEQAQAGSAKLGRPFADVSRYAAMMEEVGFVNVKQRTLKIPLNDWPKDRRMKELGALFLENMLDAVVALKKIWTFALGYSSEDADAFMGEVRSAVRNREVHAYFDFNIVYGQKPDEVQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9F8</accession>
    <name>A0A3D8T9F8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_00975</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9F8"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="3">
        <location>
            <begin position="108"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="73"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW95212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="375" mass="41837" checksum="EE05CE1E16CA944F" modified="2019-01-16" version="1">MAVPRSVLRLQARTLRWLIHLLQAHFSKLIYKYYHHVPLKPSYSFAIPCRTSPAKGSIKLVVYNPPSFNTTTLPTGSQASLTPSIPRDAKTPASPRTKFRGSQKRPCVLNFHGGGFVLGTGIDDERWARSCTELLGAVVISVEYRLAPEYPFPTAVQDGVDALEYVREHSAELGIDENLIITSGFSAGGSLAISVPMMASDLRRERGEKGTEKALYSDNHAESPKELPLVAGVISFYPGLNSIPTRDQKASRMRNPAKRMSKLLTNLFDPSYKYPATLDQGHQYLSPGVASDEVLARALPRDIWLLGCQDDMLCEEGRIFAERLGRNREEGGLEKEVRYRCIEDTVHAWDKRPNPVPKPEPIYADMCAEVRDILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9Q1</accession>
    <name>A0A3D8T9Q1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative mitochondrial amino acid transporter ARG-13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_01010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9Q1"/>
    <dbReference type="OrthoDB" id="2139348at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000064">
        <property type="term" value="F:L-ornithine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990575">
        <property type="term" value="P:mitochondrial L-ornithine transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000109">
        <property type="entry name" value="Ornithine carrier protein AmcA/Ort1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050567">
        <property type="entry name" value="Mitochondrial_Carrier"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624">
        <property type="entry name" value="MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45624:SF31">
        <property type="entry name" value="MITOCHONDRIAL ORNITHINE TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="26"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="127"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="252"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW95247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="344" mass="37485" checksum="4F4E4AA7D0EAD3BF" modified="2019-01-16" version="1">MAAAATVEYHPDSSAKLKVVGGEALMDAAEDIVFGSIAGVAGKYIEYPFDTVKVRLQSQPDHQPLRYKGPLDCFRQSLRSEGLSGLYRGISAPLVGAALETSSLFFWERVGRESLFSAGLYQRDKPLPLSALWLTGAISGAFTSLILTPIELVKCKIQVPTTVSSDGMIHKAPTPMAVIREVFRHQGLRGFWHGQLGTLIRETGGCAAWFGSKETATMMFRTLNTKYPSLVQSPAENTPIVTSESSNDLAPLPLWQQAVAGASAGMSYNFLFFPADTIKSRMQTASVEDKGPRQRFWAVGVALYKQYGLQGLYRGCGITVARSAPSSAFIFIIFDGLKSHFHFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9X0</accession>
    <name>A0A3D8T9X0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">XRCC4 coiled-coil domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_01080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9X0"/>
    <dbReference type="OrthoDB" id="8064436at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014751">
        <property type="entry name" value="XRCC4-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053962">
        <property type="entry name" value="XRCC4_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42067:SF1">
        <property type="entry name" value="MITOTIC APPARATUS PROTEIN P62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42067">
        <property type="entry name" value="YALI0C15378P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21924">
        <property type="entry name" value="XRCC4_CC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58022">
        <property type="entry name" value="XRCC4, C-terminal oligomerization domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XRCC4 coiled-coil" evidence="3">
        <location>
            <begin position="140"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="218"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="144"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="270"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="325"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW95317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="353" mass="38298" checksum="CC90D388AD463FA6" modified="2019-01-16" version="1">MAKRVLRFPRNDADAESDFVLVHITQKSGQPLNAKLIGTEGSNVYVNTLKQAQTSELKSKNFKGSQAEWDQVVGNVLLGTTAGAGLLDGIEVVTSADGKKLKINIRKRIGDITQRLGVIELQQDDDAEGDFSGFDWCGLALQATNASSHKLEDAEKKIKELEAALQESQASNRDFVKAKADHEDDLLQKFSILLNEKKLKIRDQQRLLASAKVDSKKLAAVDATRGPKRTATASGTRKRKTGHNLRGATVEEESEDEFEKMDVDADPAADSDRAVTPDRGSETETEDEGDARAELVPTVAETKDSTRAKNDDGDLLPPPRALPFAKKLAASASKVNAAKNDGSETQSDDDDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q3C1</accession>
    <name>A0A3D8Q3C1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ferric-chelate reductase (NADPH)</fullName>
            <ecNumber evidence="3">1.16.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BP5796_13215</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>2 a Fe(II)-siderophore + NADP(+) + H(+) = 2 a Fe(III)-siderophore + NADPH</text>
            <dbReference type="Rhea" id="RHEA:28795"/>
            <dbReference type="Rhea" id="RHEA-COMP:11342"/>
            <dbReference type="Rhea" id="RHEA-COMP:11344"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.16.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.16.1.9" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000028">
        <property type="protein sequence ID" value="RDW56393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q3C1"/>
    <dbReference type="OrthoDB" id="17725at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052851">
        <property type="term" value="F:ferric-chelate reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF23">
        <property type="entry name" value="FERRIC-CHELATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="151"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="259"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="360"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="389"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="15">
        <location>
            <begin position="407"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="633"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="644"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDW56393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="741" mass="82427" checksum="71A69D0718264445" modified="2019-01-16" version="1">MCSNVLSEQQGPPEAKATAPPRLLLDAGCLAHSHLLRCPCRPITSPVAAIRATYGSGMDWAVATCSILLPAASAHPSTTVSLAVLEPFASTGRVANWGEDHQARANVDTMADWLTAPLQLHSSRAFECDPLTTEQCDYYKQHWHFWYIADYAFALPTVAFFMCVIGTFIIGHVVSQVLGYRSFRGPSIWQKLVAMLRYLSYRAFHVRALRWNSAPLGILLLGLVGTIFFFCMDLVPQPYYWPNEMLYGGSPPLATRSGWMALACMPFVFATASKTNWITLLTGVSHERLQVFHRWISYAFFILALLHTFPFIVYHVRWHDMEAHFASSLIFYWTGIVALVFQAWLTFASHSIIRNFGYEFFKITHLFAVVVFIVTFFWHCDYTLTSWDYFIATAAVYVPCYCYPWLRTCFEYGVRQKAQISVEENGFIRITIPAKFDWSPGQHCFLRFTSFGLLHAISAHPFTICSSCSIPPNGQSELVFYIRHQGGFTARLYQFAVEHPGALVSVLVDGPYGGINVQKYHDSDHLLVIAGGSGAGWCLPFIERFVRCNQIPADEEHGQAAPTNDKEALPVKVRAHRSACGPVSLRVILATQDVNSRTWFLQTVSELLSKYAATNSSSGVHVQVYLTGEAAEIADPSNQIPQDSTSSKESTSSAEKTTIPDERKKVAVSGKEFGGRPELPLIVQEEAAKVADAGQSLGVFVCGPITMQNDVGNAVAHENLNIFKGAKTGGVYLHSEHFSWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q6E2</accession>
    <name>A0A3D8Q6E2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12707</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q6E2"/>
    <dbReference type="OrthoDB" id="3563801at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF80">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="59"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW57257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="155" mass="17183" checksum="A8AA21D78B8A029F" modified="2019-01-16" version="1">MGDMTADSEVAAVPRYEYTKLPGSRTIGLLYIDPVPPQKLWQPLVISFSEASLDDLGSYAVLSYSWATSDDNESMRQSKLVSCGDGTGIMVTPNCDSALRRMRSWLPPDWKAEILIDSICTNQSNDDETSQQVAMMAQIYTKAYITIAWVGEESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q780</accession>
    <name>A0A3D8Q780_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_12474</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q780"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000013">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000057">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF20">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G14670)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="412"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="55"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW57673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="507" mass="56516" checksum="7B70155E9DAF62E6" modified="2019-01-16" version="1">MAAIAPAKEEFEALEIEKVNISLNELPLPTELAQLSSDELVVIEKRLVRKLDTFLLPTCAVLFLLNILDRNNIANAKISGLTKTLNMTNTEYNTCLLMFYVGYIMTQLPSNMLITRIRPSLYICLTTAAWGIVSMCQGFTKNFAGLLLNRLVLGLVEGPFLPGVMFLMSCWYKRSELPPRIALLYGANMLATAFGGLIAAGIISRMEGKLGRPAWEWLFIIEGSITIAVAIIVIPMLPDYPGQSKIRWLPQELQLMAEWRIRKENAGIVDEDMETMWWGLKQALIDPKLYMFVVLQMSLLTAQSFNNFFPSIVGTLGYNTTITLLLTAPPYFFAFICSISISFHAAYQKERGYHIAIPMMFALIGNLLAMFLPSTGGRYFSMFLMTAGSYSPYNLCISWLSSSLPRPKVKRASALAIINLMGAGVAHFYTVYMFPDSQKPRYYAGGGVMCGACLVCTAMAMAIKRHLKNENQKFELVEMSGEIRQDGIKGSETGHGGEAVVSFRYVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q7N0</accession>
    <name>A0A3D8Q7N0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pectate lyase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_12498</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the polysaccharide lyase 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q7N0"/>
    <dbReference type="OrthoDB" id="1637350at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030570">
        <property type="term" value="F:pectate lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002022">
        <property type="entry name" value="Pec_lyase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045032">
        <property type="entry name" value="PEL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683">
        <property type="entry name" value="PECTATE LYASE 18-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31683:SF18">
        <property type="entry name" value="PECTATE LYASE 21-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00544">
        <property type="entry name" value="Pectate_lyase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00656">
        <property type="entry name" value="Amb_all"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="3 4" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0964">Secreted</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017818042" description="Pectate lyase domain-containing protein" evidence="5">
        <location>
            <begin position="20"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Pectate lyase" evidence="6">
        <location>
            <begin position="70"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU361173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW57697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="343" mass="36285" checksum="7F47B4D55D35E88E" modified="2019-01-16" version="1">MRFSIFSVGLAILGPLVLAAPTPTGEDVVEYAAIAKRATITDIATTGYATQNGGQINNRTTGGKGGTVTTVSTLAQFTAVADNSKNNDGTARIIVISGTISGATQVRIGSNKTIIGLPGAKFSGVGLFVWKQSNVIVRNIISENVLAANGDGITIQASTNVWVDHCEFYSDLSHGKDYYDGLVDVSHASEWVTISNVYLHDHWKASLIGHSDNNAAQDTGHLHVTQHNNYWYNIGSRTPSLRYGTGHIYNSYFDSMNTGIDTRDGAQILVQSNVFVNCTEPIAALYSDSTGYVNAYDNNFGIGTNTAPVGTLTPSSMPYSYSLLGSANVRAAVVGTAGATLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q9D3</accession>
    <name>A0A3D8Q9D3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12311</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q9D3"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="434"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW58381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="904" mass="102810" checksum="3B4131DD649753E1" modified="2019-01-16" version="1">MAPREFEYDAKILDPAIRDHIARFYEAADTTDHEHWASFFTSDAQLKKGAAISKGADEILASRKRSWKDGQTKEHIVFKAFPLGDQSLEVMLRGLSKWHYEDGTHAEANWAAYMGYVRVGDTVKLKDYEIYMIPKIAAVPDQQSYSIVVAGSNIHRLSDDCSDTVFGEFQFSDRTIQKWGDAQQTLANLLRISFAPLAPAILIPRVLLSHGLLGFLIRIRSSPITLFSCSHRLPITLAMPLCKLCDAIDVAAVLDSKMLNGRYRENHPKDHDLFVYGPVDIDYSPIAHHRSVEALKLSAKACALCGLVEDCFNMTLSNLRKAIAMGFSSYKLSGYQFWLCSMVQAEGLEVLGSHPDDPLEYLVLGGIRFCVDDESPLQLRGRKVSPWPNLTKIKAWIEQCREHQHAQYTRLPTRVLKIEIDKVVLQESVTVGDYITLSHCWGKEALSCLSKDTAERLALGVMTNTLPQSFQDAVLLTLQLGFQYLWIDSLCIIQDDNKDWERESERMAEVYQNSFLTISASRAASSLEGFLSKRLQPAYTALELRFGDLHHNVFAFTVPSRHAVETYRCADLGDEPLTKRGWALQERYLARRTLHFEHSQTYFECDRGFFAEDGRVYRGRGYRLLGQYETQISLLHWHSIINQYSQRELTIEADKLPALAGLAKRFTSSTNRVNQYRAGLWLDNIIGDMCWYRDTPQRTGPKLPSEPRIRPRNYIAPTWSWASIKGIIGFHEMDKPLAMVEEVHVNLDTPGSPYGKVTGGWIYLRAVKLQPYSIDNQNNHPFLWFEEHGVNFYMYIEWDAEPCGLPENAGAADDAGDDESLFAVPLGWYSTVDMERDTIFGPFCLIVKRVEHNVASHTGVVGFERVGAGLALWEKEHKVGLRRLIVEEWTDAKENKRLENMILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QEZ2</accession>
    <name>A0A3D8QEZ2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Luciferase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_11826</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QEZ2"/>
    <dbReference type="OrthoDB" id="5561043at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF16">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0288">FMN</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="7">
        <location>
            <begin position="40"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="450"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW60220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="486" mass="54296" checksum="E6287333453F1780" modified="2019-01-16" version="1">MAPKKRIHLNFFETAFTIPHRNQREAYLFNPRDAKDNSRVKDRLNYYIWLAKLAEKGKITSIFFADTYAGHETYGNDMAATFRGGSQVAQMDPVVFISAMAAVTQSVAFGVTGSTSYITPYILARTWSTLDHVTDGRIAWNVVTSYSNSAAKAMGKESVMSHDERYAAAHEYMDLVYQMWESSWEDGAQVWDAENGTAYEPSKIHKIEFSGKYHKMSGRHQTHPSPQRTPVIFQAGASKSGIEFAGKHAEALYCGSLLPPSTAAYVKAVRAEAVKNGRDPQSIKFFAGISPIIGRTVEEAQAKYEACRKNIDFIGGLAKFSGHANIDMSQYPLDEPFEFKGGPQDNTIQGIVNNFKAGYLDDIPWTPRRLGEKIAFGGLYPMPVGTASMVADVFEKWVEEADIDGFNMAYVSNPDSYETAVELLVPELQRRGLMWEDYEAPGGTFRENLYGQKGEPYLPDHHPGSAFKWNATKKQKPKENQEDAKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QHK4</accession>
    <name>A0A3D8QHK4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative wd repeat-containing protein mip1 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_11204</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat RAPTOR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10262360at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031931">
        <property type="term" value="C:TORC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071230">
        <property type="term" value="P:cellular response to amino acid stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030307">
        <property type="term" value="P:positive regulation of cell growth"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031929">
        <property type="term" value="P:TOR signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000514">
        <property type="entry name" value="TORC1 growth control complex subunit Kog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000278">
        <property type="entry name" value="WD repeat-containing protein mip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004083">
        <property type="entry name" value="Raptor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029347">
        <property type="entry name" value="Raptor_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12848:SF16">
        <property type="entry name" value="REGULATORY-ASSOCIATED PROTEIN OF MTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14538">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01547">
        <property type="entry name" value="YEAST176DUF"/>
    </dbReference>
    <dbReference type="SMART" id="SM01302">
        <property type="entry name" value="Raptor_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Raptor N-terminal CASPase-like" evidence="6">
        <location>
            <begin position="216"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="1360"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="960"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1008"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="141"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1010"/>
            <end position="1019"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW61312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1477" mass="166404" checksum="FAC8F0E39DAEE0D9" modified="2019-01-16" version="1">MTAVAVQQGAPRPQYNPRQSSHSSNVSLQHAQTQSYASGAPHIQPADAATNGSLNGIDGSERSEGNVRSASNGVQNGTGRQASIRRDRQMSAASTTTESDSAPMRRVSLYSRPATARADSSQDESVFDQARRPARATLRRSKSDYGPRFEEPESQGEEEMLEWGARHGFEDVYAEEEYVSQLASNWYMYWDEKRHATNGNPQPTSFVLQDWRMKDRLKTVSAALAICLNIGVEPPDQLKTTPGAKLEAWQDPTQPPVQKALESIGKSLQAQYESLAIRTRYKQYLDPSVEETKKFCVSLRRNAKEERVLFHYNGHGVPKPTSSGEIWVFNKNYTQYIPVSLYDLQTWLQAPTFFVWDCSDAGNILNNFERFVVKHEEEEEEKAVQDPNYVKVSHRPFIHLAACNTRENLPTNPNLPADIFTACLTTPIEMALWFFVLQDPLPTKLTPERAKKLPGRLQERRTPLGELNWIFTAITDTIAWTTLPRNLFRQFFRQDLMVAALFRNFLLAQRVMAAYGCHPRSVPELPDTHQHPLWESWDLAVEMALAQLPQLEQKEAGILPDYEYVNSSFFTEQLTAFEVYLSQGAVTHKAPDQLPVVLQVLLSQQHRVRALILLGKFLDMGPWAVNLALSIGIFPYVLKLLQSAANELKPVMVFIWTRVLAVDLSCQADLLKDSGYNYFASILKPTEGLPVDVVHSLEHKAMCAFILAMLCNGYRQGQAVANGSEIMTYCLIHVENNEWPLLRQWACLCISQLWDDLPEAKWRGIRENATKILIKLARDPCCEVRAAMLYAMTTFLGIPDLTDEVARLEEEISWSVIEMANDGNSMIRKELLVYLSKFIRRYENKFWVAAYEQLQEEREYRQYPPAEDGNDHKMGLHYARIDQRNRDGTIKAAAHGLAHNSIFAAVWKHVLIMSVDPHPEVQRNATIIIDYIHDSMLHSPLGGPAQILIDDITRRAARSAPIGNQPEPIPSTPTQQSFPNDAPPHTPGLLKRTASSFFSLASMVVGGTQSGENTLNDPNKMTIPKSPGLQKSPLPVRSRLPAEWAPPPEQNDTATTPGTYHIAKEPMSGGFQPRKLSDPPMIPLQSTFLDWSIEYFREPQMKPNEAEEPGSTDYNERLWRRSRNEGILRDTQPQKEFAGNNRWSNPAGFFNNGSQPMKMTLHQFEDHLAVSDDRDTVCIWDWKTNSRLSRFSNGNPVGSKISDLKFINEDDQAFLMTGASDGVIRIYRHYDSDKKIEVASAWRALTHLVPSNVNSGMVFDWQQVSGKLLVAGDVKVIRVWAAAAELCLVDIPARSGSCVTSITSDQMTGDIFVAGFGDGAIRVFDARVKPQEAMVKKWKDDSDKQWIKSVHMQRGGRRELVSASRNGKVKLWDIRHDKPIRTIQTTKDTLRTASTHEHLPVFAVGTGAHAVKVYNVDGRELSRVEPYSGFLHQHLKNPISATAFHPHRMMLACAARGDNHINLFTCAEKKGAAQDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QHP7</accession>
    <name>A0A3D8QHP7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_11265</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QHP7"/>
    <dbReference type="OrthoDB" id="3597048at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW61373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="271" mass="30397" checksum="84581A75722DC44D" modified="2019-01-16" version="1">MFSRLQPPSANYSPISRPHYRSRRRRSEIATMKYFLPLVVSLLVLMVDAAIQLALISSMVGYLHRSGANEYPFSYNGTSVVVNAKPKGLLLNEGHTSNGAAGSALVLVCFGGFFMIWWLRRRAARNVRKPSYLFVAYTAVSVLALVLTLVALSWTFALTNQTSGQQIDQLIASTSQHHAYPADEWTPGTWTDALLALPLIDEKDVSYLKHWRHVMNGWKWNAIPLFLVETVAVAFICLTFWEDWKIESYTEKNMGSHDKSGGGIRQSGIKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QHW4</accession>
    <name>A0A3D8QHW4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_11219</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QHW4"/>
    <dbReference type="OrthoDB" id="5426982at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052973">
        <property type="entry name" value="Fungal_sec-metab_reg_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392:SF3">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35392">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="277"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW61327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="639" mass="71374" checksum="08B851D8E6C72E8C" modified="2019-01-16" version="1">MPRVASRAAGLPATRAREGELTFFVADYLQPSYYEDASEEYIAASWLPVAPMPTPWMGAGAQQLGWGSDDVLASSSTGASLRLREQQQQFLYDGSSTGPCSLYEDVAHASYASVQQPHDLHTRTQLPSGLDYHFQTPDTPHTGQSSFHSTDPQIYQHYPVQPSSSNNHIYAWHEEYASCVSTPSHSQSLPQHRASVPQRTYHFQDETKELYTGAEVKDAVPSEPARKRNRIVTPEPDINEFVVVFENAPGALANIKRRRKLEAPVRKAAKEVRKAGACHQCRFRRRTCSTGSPCTSCIKNGNGLQELKCQHFEYSSKKRVVTFNVKAGTLKKFPTASRVTVKIDGIGQQSHPLDVSALTRLLESFSLDEKESIKQTADSNLDQESEDEPASVLIIEDGVAQNVEQWAVEYTSKFVHGAGPKFYSTTMAQILGTAYVKKGLPGSELVAAMLRLASLAFVLRAGVKYSSSDTSTSRFRTVQAKIDTILFQRLRLAERDLCQMLQKTIFRTAGSLTREQIYPVALVLWQLLRILSISASHLSNLVERFNSTESSAADYQLTCLKLVVSTHLALFRSSNPLLLDMTDNFNRDLLQNDEELIGLAMEMRKVVLKFRDKGFPDMKGSIAYRKEVFDMFRKVYGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QHX1</accession>
    <name>A0A3D8QHX1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_11203</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="45365at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051285">
        <property type="term" value="C:cell cortex of cell tip"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061245">
        <property type="term" value="P:establishment or maintenance of bipolar cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.80:FF:000049">
        <property type="entry name" value="Cell polarity protein (Tea1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244">
        <property type="entry name" value="KELCH REPEAT DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23244:SF456">
        <property type="entry name" value="MULTIPLE EPIDERMAL GROWTH FACTOR-LIKE DOMAINS PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="448"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1390"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1456"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="852"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="978"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1078"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1193"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="528"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="553"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="624"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="666"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1396"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1462"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1485"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1521"/>
            <end position="1535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW61311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1535" mass="167109" checksum="C3739128B9EB3EB5" modified="2019-01-16" version="1">MAFLFKSKKNADRSQSARDVPNGVAGSASSLQSANGRSKEAEKVAAQEQRGTPSSSVNNSITSLNGTGMNSSPEQSNGRRVPNSEPAQDLPLRNAGVPPVVQSAPANPNASLYPWSQQRLTYTTSHPSPFPRYGAAVNAVASKEGDIYLMGGLINSSTVKGDLWMVEAGGNMACYPLATTAEGPGPRVGHASLLVGNAFIVYGGDTKLEDTDLLDETLYLLNTSTRQWSRAVPAGPRPAGRYGHSLNILGSKIYVFGGQVEGYFMNDLVAFDLNQLQVPTNRWEFLIRNSDEGGPPVGQVPPARTNHSMVTYNEKLYLFGGTNGFQWFNDVWCYDPIPNAWVSLDCIGYIPAPREGHAAAIVDDVMYIFGGRTEEGADLGDLAAFRISSRRWYTFQNMGPSPSPRSGHSMTAFGKQVVVLAGEPSTATREVQDLSIVYLLDTSKIRYPNDQQIQSTPAGERVPGRRPSGGDKSGMGASRGLTSRDGSAGPEARRPTGTPRESVTSPQGGFGRNNGIPNVNGNDANGMAPGSAQPQGAPAGSRLPRASMAQAPLGPPPQQQPPPPRMNGAASVANGKGKSEKGYGPAIDTSVRNPSLDGVKTQTAVLAPSPRDSPQAKESPVTNGRRTPTQQQQPGPKPLARVNSDDPPQLATSSVPVRSESKTRQGRQQNSLDSISESTLRNVTNRQPSPPPAARTVANPPVNRRGSARNSQTVNLLKELDAAKNKNAWYASELELARKAGYVPTHSSSPTLEQRATESFDDEDKPLIEALLAMKAELTNIQGSIDKQAIIASKKIAEVEKQRDAAVSEAVYAKAKLAAHAGSQTSTPQPDSDARDLGMMSADRSNDIGRKLAAALAEQKNLNNKLELMTAEVEAEKRGRKLAEEIATTAQTRLSQLEAYQQQNSAEVERLKAELHECQTRAREEGIVCAEALAAAQLVKAEKEELSQKHQEVLGNSKDSSDTFDSLREAIAASADMKSLLERKLDEERDLREKIESKLNILKGEHETRTTELETAQRRLKDAEELAEQYATEARTHREAVMAGLDKVVARDAGPRTSLNEDRIIALTGQAQAANALARKYQAAADAASDKLRSAEERIAGLEAYQEQASRDGMSIRKQLQAAMRETQSLQAANSEMKYQLANQQLETNAVHVQHNTLKDILGERGISPAGAARVRGLGSPQSGSNTPDIVRHRELEQQLAASMAAHQEMRETYESREQQAESAYREKLGQLENDYQSAVHYVKGTEKMLKRMKDELSKYKAENARMKDQLVEADEKNASRDVPSDWEDERTKLNKQIETLQADLSKSAAHLESQLAQIKTELLTAQKERDQLKQSHEVTQRELSASAQEAKANLAQLQEENALLERRAKDAEQKVSLLLDQVEQSVDTYRRQSRQAESMNGHQRNASGQESLSDSSLYEAADGSNNRNSMALDSLATELESLRSHWETTNKNYRTSNAFDFDDRPSTKGDADDKGPELSGSLADWRKRLDAEERNSKEGVSDQPLSPSRREMSPSGREVGTQSMHTNKSQVNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QHX2</accession>
    <name>A0A3D8QHX2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lipoyl synthase, mitochondrial</fullName>
            <ecNumber evidence="10">2.8.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Lipoate synthase</fullName>
            <shortName evidence="10">LS</shortName>
            <shortName evidence="10">Lip-syn</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Lipoic acid synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_11297</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>[[Fe-S] cluster scaffold protein carrying a second [4Fe-4S](2+) cluster] + N(6)-octanoyl-L-lysyl-[protein] + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 S-adenosyl-L-methionine + 4 H(+) = [[Fe-S] cluster scaffold protein] + N(6)-[(R)-dihydrolipoyl]-L-lysyl-[protein] + 4 Fe(3+) + 2 hydrogen sulfide + 2 5'-deoxyadenosine + 2 L-methionine + 2 reduced [2Fe-2S]-[ferredoxin]</text>
            <dbReference type="Rhea" id="RHEA:16585"/>
            <dbReference type="Rhea" id="RHEA-COMP:9928"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10475"/>
            <dbReference type="Rhea" id="RHEA-COMP:14568"/>
            <dbReference type="Rhea" id="RHEA-COMP:14569"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="ChEBI" id="CHEBI:29919"/>
            <dbReference type="ChEBI" id="CHEBI:33722"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:78809"/>
            <dbReference type="ChEBI" id="CHEBI:83100"/>
            <dbReference type="EC" id="2.8.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="10">Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Protein modification; protein lipoylation via endogenous pathway; protein N(6)-(lipoyl)lysine from octanoyl-[acyl-carrier-protein]: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the radical SAM superfamily. Lipoyl synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.8" evidence="10"/>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QHX2"/>
    <dbReference type="OrthoDB" id="3231at2759"/>
    <dbReference type="UniPathway" id="UPA00538">
        <property type="reaction ID" value="UER00593"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016992">
        <property type="term" value="F:lipoate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009249">
        <property type="term" value="P:protein lipoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000036">
        <property type="entry name" value="Lipoyl synthase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00206">
        <property type="entry name" value="Lipoyl_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031691">
        <property type="entry name" value="LIAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003698">
        <property type="entry name" value="Lipoyl_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00510">
        <property type="entry name" value="lipA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004019">
        <property type="entry name" value="PRK05481.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009544">
        <property type="entry name" value="PRK12928.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949">
        <property type="entry name" value="LIPOYL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10949:SF0">
        <property type="entry name" value="LIPOYL SYNTHASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16881">
        <property type="entry name" value="LIAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00271">
        <property type="entry name" value="lipoyl_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01058">
        <property type="entry name" value="lipoyl_synthase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6 10" id="KW-0408">Iron</keyword>
    <keyword evidence="7 10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Radical SAM core" evidence="11">
        <location>
            <begin position="142"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="159"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>2</label>
            <note>4Fe-4S-S-AdoMet</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="374"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW61405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="407" mass="45630" checksum="54AF412D1765B695" modified="2019-01-16" version="1">MAVNLSRFRCLNTPPLRQASRQLLAASPAASRCLATETSATDLTPKRRPTYFKDKLNAVPSFTEFIGMQEEPLSNEDALELRTAMVGPAGKKRQITRLPEWLKTPIPDNANYKKIKKDLRGLNLHTVCEEARCPNISDCWGGGDKSAATATIMLMGDTCTRGCRFCSVKTNRAPAPLDPHEPEHTAEALARWGLGYVVLTSVDRDDLVDGGARHFTETIMKIKQKKSDILVEALTGDYQGDLEMVAMVAKSGLDVYAHNVETVEELTPFVRDRRAKFRQSLAVLEAAKKEVPTLITKTSIMLGLGETDEQLWETLRELRKVDVDVVTFGQYMRPTKRHMKVEEYVTPERFELWRQRALDMGFLYCASGPLVRSSYKAGEAFIENVLKKRKGMTILRDEATGMQKAVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QI01</accession>
    <name>A0A3D8QI01_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Altered inheritance of mitochondria protein 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">AIM11</name>
        <name evidence="5" type="ORF">BP5796_11182</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AIM11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QI01"/>
    <dbReference type="OrthoDB" id="3558022at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038814">
        <property type="entry name" value="AIM11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39136">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39136:SF1">
        <property type="entry name" value="ALTERED INHERITANCE OF MITOCHONDRIA PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="29"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW61290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="171" mass="19124" checksum="A76242F8CA1AF56D" modified="2019-01-16" version="1">MADSLPSPTSMAPANTKPDYFSRRSRRQLSLFAAGVGFFGLTSIITRRALVRRYKATIPKFFQPNNRPSMEFDGALEAFEALSIATINVASVGMIAAGGLLWAFDISSIEDMRKKVRTNMGTEGLRNDQDAEEEIEEWMAGILGRKDETLKQRARAREARNQKKEEMDGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QIU8</accession>
    <name>A0A3D8QIU8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycoside hydrolase family 3 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_11530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QIU8"/>
    <dbReference type="OrthoDB" id="2588159at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017659849" description="Glycoside hydrolase family 3 C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW61638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="169" mass="18286" checksum="16EC0CC08D47C66A" modified="2019-01-16" version="1">MGFWNYLHCFTIVLTLSPAVLGFPFNYTNALTNAAMEPSSNIRPRFDNYVDPDTVTSDIASVKKADAGDIEFTPTDPQLPEVYQASDSIDAGYAYEYLSPDNFDLQLATVTNGVLAAAGPAYQAMVIRGNDSLTVFGLEKLVEYAQQGLPIIFCGGLPSTLASYNESGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QL03</accession>
    <name>A0A3D8QL03_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_10795</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QL03"/>
    <dbReference type="OrthoDB" id="19653at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="1">
        <location>
            <begin position="155"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW62493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="247" mass="27181" checksum="631C0A919E49A3A2" modified="2019-01-16" version="1">MSPALSFSRPDIQPDGDRVVAVGWSSDGHLAMSLGWTLPLLDIRPPDAVLGFYCPTDYEDPSWASPNLPFGQDPAPSPGTGYNFLYDGLHDKPVSVYTPRASKLALGGWKSLEDPRSRIILHMDWEDKSLPVLINGLRRTGANSVTNPPFPSVEQIQAISPLAQIRAGNYRTPTFLVHGTRDDFVPWQASQRSYGALRKRGVPIALVILTDGLRVFDLYPAIKRNPAAVKEVNDGYEFLGAHVKPHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLT2</accession>
    <name>A0A3D8QLT2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS transporter-11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_11085</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLT2"/>
    <dbReference type="OrthoDB" id="5290825at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015798">
        <property type="term" value="P:myo-inositol transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015791">
        <property type="term" value="P:polyol transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000100">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050814">
        <property type="entry name" value="Myo-inositol_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020">
        <property type="entry name" value="PROTON MYO-INOSITOL COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48020:SF25">
        <property type="entry name" value="SUGAR TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G05830)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="201"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="223"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="418"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="476"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="516"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="547"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="126"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW62783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="639" mass="71769" checksum="968712891E154557" modified="2019-01-16" version="1">MADTEKVGAPKRSDESDHTHVENASLPGGKNADNMTADQLRANINAKIANPLAGYSHAELSQKGEDFVRQHSVGDDEDIRAFQLGAILAQDPKRHAEVDGLTQDEADVLAREISHRWSQPRLLYLVIILCSTCAAVQGMDETVVNGAQIFYAKQFGIGDKTSQRDSWLVGLVNSAPYLCCAFIGCWLTIPFNNWFGRRGTIFLTCCFSALACFWQAFTNTWWHMFIARFALGLGIGPKSATVPIYAAECTPPQIRGALVMQWQMWTAFGIMVGYAADLAFYSVPDKPNITGLNWRLMMGSAMLPAVIVLCFVFLCPESPRWYMSKNKYQKAYQAMIKLRYNKVQAARDIFYMHTLLEAEKASLLVGQSKVKEMFTVPRNRRAMQASEFVMFMQQFCGVNVIAYYSSEVFVQANLSESAALAASLGWGCINFLFAIPAVYTIDTFGRRNLLLTTFPLMSLCLFFTGFSFWIPSSSTAHVACIALGLYLFGIVYSPGEGPVPFTYSAEAYPLYIRAQGMSLATATTWFFNFILSVTWPSLLQSFKPQGAFAWYAVWNIIGFIGVLLFVPETKGKTLEELDQVFAVPTHKHAAYGLRQLPYFTRRYIFRQDIEPERLYDTDAVEHHERSFSTEKNTDQTARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLT4</accession>
    <name>A0A3D8QLT4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative flavin carrier protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_11088</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transient receptor potential (TRP) ion channel family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLT4"/>
    <dbReference type="OrthoDB" id="5212126at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010308">
        <property type="entry name" value="TRP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040241">
        <property type="entry name" value="TRP_Flc/Pkd2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032800">
        <property type="entry name" value="TRP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145:SF2">
        <property type="entry name" value="FLAVIN CARRIER PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31145">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_7G01610)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06011">
        <property type="entry name" value="TRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14558">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01320">
        <property type="entry name" value="TRP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017814891" evidence="9">
        <location>
            <begin position="25"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="506"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="537"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="568"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="domain" description="ML-like" evidence="10">
        <location>
            <begin position="26"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="652"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="725"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="753"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW62786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="788" mass="84963" checksum="93074ABF871C8114" modified="2019-01-16" version="1">MRSSILSPIVFLTSLLSIISSASAIRLIESKSLNTCQDNSSFTASLFDVVFTPNNLTLTFDVVGVSSIQGNVTFGIEVSAYGYVFIKQTLDPCTSNLNGLCPMSTGQIDISSNLVLDQSVVDQIPAIAYGVPDLDANVKILINSTTDPGTSLACVEASLSNGQTVDQKGVGWATAVISGMALVASAVTSGLGHSNTAAHVAANALSLFGYFQSQAIVGMTAVPLPPIVQSWTQNFDWTMGIIEVDFMQSIATWYQKATGGTPATILNTLTTTSVTVEKRSVPKFAKRSVDTTIKLLTRAHEQMTKRSDSTSTTTSGIYIVKGIHRVAFRAGIESTNLFLTGLAFFCIFIVFTVLFVAMFKGFCEMAIKSKWMKSDKFQDFRNGWFTVLKGIMFRMVLIGYPQMTVLCLWEFTQVDSPAEVVLAIFFFFGMTGTLAWAATKVIRIAKRSVAMHKNAAYILYSDPSALNKWGFLYVQFRATAYYFILPVLVYTVIKGMFVAFGQGSGTLQAVALVIIEAIALIGASVIRPWMDKSTNTFNISICAVNFLNAIFLLIFTDVFNQPGLVTGVVGVIFFIANAAFSLVLLILVLLATIYAFVRKNPDTRYQPVADDRASFIKSQTQLTTELDALGATARGDMKGGYKHNLDLDDDNDSWSSDSMHHPANMPLPPSTANSGNLHSGHGSIRDAPHSPIDPAVPLFPAGGRGPPPNYQDNPQMFQTGGAPFQQVSRPNSAFNRSAAGSPGPGAYGPNASTSNVSGYRMANDNSPGGHRNQNNASPWQRGAGYDHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLW8</accession>
    <name>A0A3D8QLW8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter-31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_11128</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLW8"/>
    <dbReference type="OrthoDB" id="5298304at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015225">
        <property type="term" value="F:biotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901604">
        <property type="term" value="F:dethiobiotin transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015295">
        <property type="term" value="F:solute:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905135">
        <property type="term" value="P:biotin import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000399">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000278">
        <property type="entry name" value="Putative MFS transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF33">
        <property type="entry name" value="VITAMIN H TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="332"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="426"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="49"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="498"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="498"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW62826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="536" mass="58901" checksum="D6FD934F67A6148C" modified="2019-01-16" version="1">MEDVHGAKGIRDNHPAAESSNELPAHDIEQNDVEVERIEAVYRKIDRRIIPAFWVLYFLCSAIRSNVGLAQTMNASSGHDLMQVLHLSSKQTSTALALFYVAYVLFDLPSNLVMTRLSPRVWMARIVIAVGIIGSCFAAVKAAWSLLFLRFLLGVVIAGMWPGMSYYLTLFYPPSRTGKRIGYYFTAAQVSAAVVGLVSAGFQKMDGLGGLVGFQWMFLLYGLCAIVLGFILLWWLPDRPLPPGEARVKKGVMKWLPSTPPVLSGEDAEIHYQDLTRVYHPRPWGVKDLVAVLFDWRLWPLTLMYFGVVGVGIGTQLYGTVIIQGISSSFSGVTLSLLFAPIWIMDLIAILIVTPISDRFHHHRAVFFSAAVCIQIAGLLTTTFAPHSQPWARYGGLLMVGFGLGPTVPICMTWTNEIFQRRHGEVGVAAAAALVSGLGNLGSVTTTYALYTGWPEDAKKGPLQYRKSNLTMIGILCLSILSSIVMTLLLKFIGNKPSSKLQSSGSSTSEGTAEFQDGAARRELAQRGFGRMGWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QMJ5</accession>
    <name>A0A3D8QMJ5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Translation initiation factor IF2/IF5 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_10986</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QMJ5"/>
    <dbReference type="OrthoDB" id="10255414at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor IF2/IF5" evidence="5">
        <location>
            <begin position="207"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW62684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="339" mass="36794" checksum="25B406514C9A5F22" modified="2019-01-16" version="1">MAGEEIDVDRKPRKSVAFSDGTTIVDENGDVTLKEDGHDDSANTALSHSPSTPPLSAALGAFTDSNQGGDAPEDGAGDGDDIGDMLKTMKKKKKSKPKTEDAEGGDAPAADDGGLDLSSMKKKKKTKKPKEGAEDEFAAKLAALDIEGKEGEGEAPAEEKPVDAGDMEKGTGIWQHDETKPIGYELLLGRFFSLLAQKNPDHASSGSRSYKIPPPQCLREGNKKTIFANIAEICKRMKRTEEHVTAYLFAELGTSGSVDGSRRLVIKGRFQQKQIENVLRRYIMEYVTCKTCRSPDTDLNKGENRLYFITCNSCGSRRSVTAIKTGFSAQVGKRRRQQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQM4</accession>
    <name>A0A3D8QQM4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Arp2/3 complex 41 kDa subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">p41-ARC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_10452</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat ARPC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW63950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQM4"/>
    <dbReference type="OrthoDB" id="406844at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000220">
        <property type="entry name" value="Actin-related protein 2/3 complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017383">
        <property type="entry name" value="ARPC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709:SF2">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038093">
        <property type="entry name" value="ARP2/3_su1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="10">
        <location>
            <begin position="50"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW63950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="331" mass="35780" checksum="05C7D88704B2C9EC" modified="2019-01-16" version="1">MASPEVHHLFYHPIADHSFSADRETLAVARDTSVELYGRSGSGFKIKDELKGHDKTVTSVDIAPNSGRIVTCSQDRNALVWEPSPTGYKPTLVLLRINRAATFVRWSPSETKFAVGSGARVIAVCYFEEENDWWVSKHIKKPIRSTITTVAWHPNSVLLAAGSTDAHARVFSSFIKGVDARPDPGVWGERLPFNTVCGEYLNNSAGWVHAVSFSPSGDALAFAAHDSSITVVYPSGPDQPPKAVVSVSTPLLPFMSLIWNGEAEIIAAGYDCEAFKFQGSEGGWQLTGSVGSPGKAHQNTISTIRIYEGSAEAVQKFSSSGVDGRVVIWDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQV6</accession>
    <name>A0A3D8QQV6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial</fullName>
            <ecNumber evidence="5">1.1.1.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Isocitric dehydrogenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">NAD(+)-specific ICDH</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_10694</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-threo-isocitrate + NAD(+) = 2-oxoglutarate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:23632"/>
            <dbReference type="ChEBI" id="CHEBI:15562"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.41"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Octamer of two non-identical subunits IDH1 and IDH2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.41" evidence="5"/>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQV6"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004449">
        <property type="term" value="F:isocitrate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006102">
        <property type="term" value="P:isocitrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.718.10:FF:000001">
        <property type="entry name" value="Isocitrate dehydrogenase [NAD] subunit, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004434">
        <property type="entry name" value="Isocitrate_DH_NAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00175">
        <property type="entry name" value="mito_nad_idh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835">
        <property type="entry name" value="DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11835:SF42">
        <property type="entry name" value="ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="6" id="KW-0816">Tricarboxylic acid cycle</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="13">
        <location>
            <begin position="42"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00071938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW64192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="377" mass="41191" checksum="B0E504A8E2B43BE2" modified="2019-01-16" version="1">MLMRSSVRSAQSLLRTAQPATRSFATVQSDIFKPTKYGGKYTVTLIPGDGIGAEVAESVKTIFKADNVPVEWEQVDVSGVESGNKHSEELFRESIASLKRNKLGLKGILHTPVERSGHQSFNVALRQELDIYASVVLIKNIPGYQTRHNNVDFCIIRENTEGEYSGLEHQSVPGVVESLKIITRAKSERIAKFAFSFALANNRKKITCIHKANIMKLADGLFRNTFNAVAKDYPTLETNDMIVDNASMQCVSRPQQFDVLVMPNLYGGILSNIGAALVGGPGLVPGCNMGRDVAVFEPGCRHVGLDIKGKDQANPTAMILSGSMLLRHLGLDEHANRISKAVYDVIADGAVRTRDMGGNNTTQQFTRAILDKMELAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QTZ8</accession>
    <name>A0A3D8QTZ8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Peptidase S33 tripeptidyl aminopeptidase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_09853</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QTZ8"/>
    <dbReference type="OrthoDB" id="425534at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013595">
        <property type="entry name" value="Pept_S33_TAP-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051601">
        <property type="entry name" value="Serine_prot/Carboxylest_S33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248">
        <property type="entry name" value="2-SUCCINYL-6-HYDROXY-2,4-CYCLOHEXADIENE-1-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43248:SF25">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08386">
        <property type="entry name" value="Abhydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="136"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S33 tripeptidyl aminopeptidase-like C-terminal" evidence="4">
        <location>
            <begin position="530"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF08386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW65161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="693" mass="75669" checksum="9DA8C75731CAAE1A" modified="2019-01-16" version="1">MVMVTRKIGTISPTVSASDKVGISRSTWLRSLAVSSAAIFLIFKSISIAPIFSPSTDVGTMSKKTPIVTASKGFKWENISPSKELLYHDCFGKLQCARLEVPLDYKRTDGKGLKVAVALIRQPAKVPVTDPRYGGAVIIEPGGPGGSGVDQLLRAGSEIQSIVSSHIEPEIASFNSENKYYDIIGFDPRGVNNTTPGVRCFPDALVAQNWKLQSETIGIFGSTPGALPRLWERSQALSRGCSEALMEEVNGERVAEHLNTIPVVEDMVHMIERHGQWREKQALATQDAYAQVYGTETTKAMLDRTKWSKGKEMLYYWGFSYGTVIGTTFAAMHPERVARVVVDGVVDADDHYHGTKANNLWDADSILSQFFIYCSEAGPAKCSFYTPGGPKAIQAIYDELISNIYKHPVVVPGSATHGPEIITWSDIKSVQSPSLYQPLHRFPHFSMLLSDLVTGNGSKFAEYKQHKYGPICSAADCGSEHNTCSPGHLPLATPEAYSAILCTDSSRLGDVSKEEFEAYVQRMTNQSASFGAVWAHNRLGCVGWNVTAKWSLNHSIAAIKTAHPVIFIGNTFDPVTPIRNAHKMSSQFPGSVVIEHRAEGHCSLAAPSLCTMRHIRNYFQTGATPTSDDGSSGASCETDLKPLVDAVPNEWSSYPESIDVLAFAHSEAELQDIRDLKILLRASKRFAESSVAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QU26</accession>
    <name>A0A3D8QU26_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Epoxide hydrolase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_10035</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QU26"/>
    <dbReference type="OrthoDB" id="7130006at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004301">
        <property type="term" value="F:epoxide hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097176">
        <property type="term" value="P:epoxide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010497">
        <property type="entry name" value="Epoxide_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016292">
        <property type="entry name" value="Epoxide_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661:SF35">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21661">
        <property type="entry name" value="EPOXIDE HYDROLASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06441">
        <property type="entry name" value="EHN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001112">
        <property type="entry name" value="Epoxide_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0058">Aromatic hydrocarbons catabolism</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Epoxide hydrolase N-terminal" evidence="5">
        <location>
            <begin position="4"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="4">
        <location>
            <position position="309"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001112-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW65343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="411" mass="46128" checksum="48A11A091849EDCC" modified="2019-01-16" version="1">MAPERFTIDVPQSKIDTLKTKLSLAEFPDELEAAGWDLGAPLADVKRLTKAWENYDWRAAEEKLNQIPQYHTDIEVDGFGKLDIHFVWQKSEVKNAIPLIFVHGWPGSFIECQHILPLLAQPGGPAFHIVAPSLPNYGFSESVKKRGFAAAQYAETCHKLMLQLGYNQYVTQGGDWGYVITRSMGLLYPDHVKASHLNMISTDSPPTFRKNPILALQHAVTPYSEVENVGFERTKWFSKEGRGYNLEQSTKPQTLAYALNDSPVALLAWIYEKLHDWTDSYPWTDDQILEWVSIYQFSRAGPGAAHNIYYEVAHTQPGPGNVLRDTLKEYIPKVKLGLAFNPKELVVPPKTWGRALGDVVFESDNPSGGHFYATEKPELLARDLRTMFGKGGGAYGVVKGLSGYDDTRARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUF8</accession>
    <name>A0A3D8QUF8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NPP1-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_10131</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Necrosis inducing protein (NPP1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUF8"/>
    <dbReference type="OrthoDB" id="89086at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008701">
        <property type="entry name" value="NPP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33657">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33657:SF8">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00600)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05630">
        <property type="entry name" value="NPP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029958">
        <property type="entry name" value="Necrosis-inducing_protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017717303" evidence="3">
        <location>
            <begin position="24"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW65439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="244" mass="25516" checksum="E0E457A0390581FF" modified="2019-01-16" version="1">MAVISKILNLSLGLAAAAATVTATPVELHSRGTIGSDVIVGFDQTVPSGTTGDVYLAYQPYLYVVNGCVPFPAVDAAGDTNAGLKTTGASDGDCSSSTGQIYVRGETYGSYYGLMYAWYMPKDEPSDGLGHRHDWEGAIVWLADATSTTADNIVAVCPSAHGGWDCSTSSYSVSGTQPLIDYYSIWPIDHQCGLTSTVGGTQPLIAWESLPTVAQTALATTDFGSAIVPFIDANFETNLGKATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUN9</accession>
    <name>A0A3D8QUN9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_10083</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUN9"/>
    <dbReference type="OrthoDB" id="1470350at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11069">
        <property type="entry name" value="CYP_FUM15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.630.10:FF:000051">
        <property type="entry name" value="Cytochrome P450 monooxygenase (Fum15)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF166">
        <property type="entry name" value="CYTOCHROME P450 12A4, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0349">Heme</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="2">
        <location>
            <position position="500"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW65391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="555" mass="62497" checksum="9243C707DE521C17" modified="2019-01-16" version="1">MSTDIPTPLKLAILSASFCVANIILFPQVFPNTPLTKLFLIFTSINFGVWGFWKIAIFPYWFSPFRHYSRPKGALPLLGHGQIVFQRPSGDSFLRLMNEVPNEGIIRFAGFFNVDWLLLTDQRSLSEVLVHKSYEYEKPKQLRSFLRMILGDGLILVEGDEHKFQRKHLSPAFSFRNIKELYPIFWSKAVELTRGVAAEVHANPEPSKNEKEAYPRSVVEINHWANKVTMDIIGVAALGRELNALTNSDDELIKNYEEILEPTAEKAVYFTMNLFFPRRFIAMLPWALNATLEKTTGNLRAICHELVREKKSTLKGEHTDSKDILSLLLVSNNFADDMIVDQLLTFLAAGHETTSSAFTWATYLLAEHPEIQTKLREEIRANIPSPFTANADNTDLGNLLESLPYLNAICNEVTRLYPPVPTTIRIAVSDTTIGTQFVPKGTRIYISPWAINRSSALWGAKAAEFCPERWIDPATGRANNTGGVSSNYSIMTFLHGPRSCIGERFAKAELKALIAVFCGTFSMEWAGTERPIPAGAITAKPHNGMRIRLQKQDGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUT5</accession>
    <name>A0A3D8QUT5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAD(P)-binding protein-14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_10229</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUT5"/>
    <dbReference type="OrthoDB" id="276721at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044877">
        <property type="term" value="F:protein-containing complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051207">
        <property type="entry name" value="ComplexI_NDUFA9_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126:SF16">
        <property type="entry name" value="MIOREX COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12126">
        <property type="entry name" value="NADH-UBIQUINONE OXIDOREDUCTASE 39 KDA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="2">
        <location>
            <begin position="8"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="116"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW65537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="293" mass="31251" checksum="87A165CE18EDD939" modified="2019-01-16" version="1">MASTKRLVVCGGNGFLGSRICRSAVARGWEVTSISISPSRSGEPTWSSVTSSPTPPSWAHKVTWERADILKPNTYSPLLKDADYVVHSMGILLEADYKGVVSGKESPLTGLKRAFSSTKAGSQNPLTRAKGEDLKPQEKDGQLTYELMNRDSAIALAREAAEHQVPAFVYISAAAGAPVLPARYITTKREAESTIASEFPRMRSAFVRPGFLYDSSRAFTVPLAAMTGLGAVFNSVTGGVFGGIMGAAGTKPLKADVVADAVVEALSDESVKGPIEIQEIEELAQKAWRKGML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QXN8</accession>
    <name>A0A3D8QXN8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxyvinyl-carboxyphosphonate phosphorylmutase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_09342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QXN8"/>
    <dbReference type="OrthoDB" id="1923844at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00377">
        <property type="entry name" value="ICL_PEPM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039556">
        <property type="entry name" value="ICL/PEPM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905:SF13">
        <property type="entry name" value="CARBOXYVINYL-CARBOXYPHOSPHONATE PHOSPHORYLMUTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42905">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13714">
        <property type="entry name" value="PEP_mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW66593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="38370" checksum="27DE2F710D34637E" modified="2019-01-16" version="1">MSAYVQQEPYPFQFTPPVYEKGGKAGVTQDVTITLKNVRGRIPSLQASKLRTMMLQAQKSPDHILAHVCSYDGLSSRLVEESGQPMIFLSGYAVASGYGLPDTGYIAMQEMCDKIQDAARQVSVPIMADGDTGYGSPMNVKRTVESYALAGAAGIMIEDQTWPKRCGHTKGKSVVSRGEAYARIQAACDARDEGLDIFVLARTDSLIHGWDEAITRVKEFVRIGVDAVFIEALPDREAMAAATKLVDVPMFANIIEGGKTANLSAKELADLGFAAVAYPWRLVAAKLKATREAIESLKQSMTQGAPPSILTYDEVCYGVGFNKYWEREERYKFNEDNLVNQVVKNGVNGNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QY06</accession>
    <name>A0A3D8QY06_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF1989 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09452</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QY06"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018959">
        <property type="entry name" value="DUF1989"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31527">
        <property type="entry name" value="RE64534P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31527:SF0">
        <property type="entry name" value="RE64534P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09347">
        <property type="entry name" value="DUF1989"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF1989" evidence="1">
        <location>
            <begin position="6"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW66703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="218" mass="23506" checksum="AB81F94423265A15" modified="2019-01-16" version="1">MPAATTIPARHGIAVPLQAGQSIKVLNTHGTQVIDTFAFRVSSFPPSAASPSYFADITTQLSMQHTRASLNATIPKPGDGLFDNRREKILTFVEDTTGGRHDTLIAACDTFRYIELGGGHEHRNCADNLVEGLRAIGVNPPQFTPSPLNLFMNIPVHTDTSNSKQGNTTLSFEPPTSKAGEYVVLKAEVDLVIAFSACPQDILSINCGNPVDAHFEIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QZ05</accession>
    <name>A0A3D8QZ05_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09756</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW67007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3562788at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW67007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1283" mass="143664" checksum="3FE3493E599082F1" modified="2019-01-16" version="1">MTSVESYVIGTSQPLSPDGVIGLGSIVVDPQHPGRPLNFGERLPIHRSRIYGVQKQGWTVTHEQLISGRGIRWDLIRTSILSRGLDRAADSKHNPNKVYKFARIETHSFTPDDGYIQQSLLLPSVTEYIDRGKLFRSQSIYMVIGVQMAYGMTVETTREPGHILEAGSMFGEPWGKVFASGEVQLGHEGGVFPGKSSGESTESVNCYKLLKIKTRRGLEPRRNAYKLEGANSDAGGRWKTLERPQSNAGIKNMGFQPRPDANDEDTLMSSLGDPENEVASDTKLDQPTYNIQYMENPRAQSIFSDTQFTKSYTSLVKLEVEQDLVYQFLEGLFGDMELVQLYHEAPELMDRESFLRNHSRILKRYFHKFSATTINPDLKLAIQILGKHAERNQIAAETWDRLFRQPLTEQTVMEFTGSRQSNSLIKDNDIGSQSSDNSELDISEITIGQKFKATEQQLETVCEQFLSMKALLFYGPVFEEYKRNLRYFLHPPSDLHEALDSRNVHAIQRVLDNDFHGAAQGEYVWLGELRNRQCSNKDIARLLVEQLEDAPWIYFEPKIPRAEIIQPTLHVPQCVHYGGRSLSSTQKGKSSTPSFVSAKHSSVAFDEPEFRESLSEICGLAGVVPTNRDQRQWVGAVAFENNNSTALVSYYMGDTEGMSRTRPLLSRLDEALDRLCSAIGMVQSHGLCCNCYTILCFPFHDNGQTTAVELCRIDLSIAVELFQALDSLAASHTEAAVRRCKAAANTVLNIVCGEGFEDDCRDSDDNILHMCSLAVQILTVGFLSYCQAHTGSMELFFLDNPLETIRLYGAKHPSASNQHVVLELQQLSCVGDMLQNNAVLTFKLVSANNMSRVIFRDERVDLLTSPEDFIDTWGPGQYIVSSPPDKEPEILSMYIGGGIIEAVDNTGRSLHWSEGFHAPITTSIPLSPREKVIIGASVRENPHCGLNIEQCWQRYETYMLPLGTRADYWRLAEIQAGLQGSQYLTVLLAGAWEKVPGRTLKKELLSYPNDDLLQILDSAWGLEVSLCTALARRVFVREALAGIMPALIGSKVPPPPGWDTLRDECNFIEALQSSEMKDWLNGLNYYANESYKLAIQCIRYGLQILANTGIEPGSGSLVVACIRTGQAFQCLKIACEDKSFWARILADSPDCATFAYITTKCLQSNYHACRGPSSSWRGVTEMLETSVCRHILQAQDTETPWVFEDNKVYRIGAENAGLYAQVEYRNVSEGPRLIVSSTGIPRGLFKRYLVFDRGLRHERLRERQTLSSSGKQVLVSSKKLIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QZ51</accession>
    <name>A0A3D8QZ51_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Amine oxidase</fullName>
            <ecNumber evidence="11">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_09690</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="11">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="10">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="10 11">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="11"/>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QZ51"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000001">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF91">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0186">Copper</keyword>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="13">
        <location>
            <begin position="263"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="685"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="688"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="9">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="10">
        <location>
            <position position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW66941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="710" mass="78280" checksum="4AB2371C1C07D470" modified="2019-01-16" version="1">MSTDQATAIPLRSRTSIPHPLDPLSVAECETARQSILKLRGSNVAIRFRAIALDEPLKTELCQFLDAEHSGTLSSNTPRPPRVAKAQYDVVNVNKDVAYTESWIDLDSGDEVRHRAVERHHQAALTTHEFQAFADTCFASPLYNKAIDEFKLPEGFVVTVDPWPYGGPDEDEIAPRYMQGLCFARDTRSGNADSNHYAYPLPIIPILDTATGEIVRIDRLATGGKEDGLKYGTHKASILDHCQPAEYIPELLGIPLRTDLKTLNVVQPDGPSFKVSNESLVEWQKWRFRVGFSPREGATLHDVRYDGRSVLYRLSLSEMTVPYGDPRPPFHRKQAFDFGDAGAGRAANNLELGCDCLGTIKYFDAVMAEADGSASVSKNVRPCTDPGSIGWKHTNFRTGRAVVTRSRELVIQFIITLANYEYIFAYKLDQAGAISVETRATGIVSVVNIDPGKTSPWGNVVSAGALAQNHQHIFCIRIDPAIDGNANTVIMEESLPMPMSKEINPFGNGYEVRQTPVTKSQWIDAEPRNNRVIKITNQSKYNPVSGKPVSYKFTPSATQLLLAHPDSILARRAQFAQHHVWVTKYKDGELWAGGEFTNQSKKEVDGVSDAVARQDIVENEDVVVWNVFGLTHNPRTEDWPVMPVEIFQLHISPSDFFTANPAIDVPGSKNQSSILAPGAKSCCDESGAVQQAASSHLQGTGPDLDPKTNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R2P8</accession>
    <name>A0A3D8R2P8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_08989</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R2P8"/>
    <dbReference type="OrthoDB" id="3527108at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW68332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="387" mass="44062" checksum="F20DE4ECAFDE243F" modified="2019-01-16" version="1">MKNITASKTPPIVDNFPRAAAAHSASDLPSIPSWNKPPSPHVRERTPLFIGFTRNWRLIQQAVVSYITAGWPPEDIYVVENTGVMDSNKEGLLSLQNPFFLNHTRLSMLGVNVLITPTLFTFAQLQNFYLWNAIQEKYPAYFWSHMDVIAASYEDRTPFIPLYQRALTELRAVLSPETPPWALRFFAYDRLALVNTATYRDVGGWDTHIPFYMGDCDMHSRLTMGGYSQEEREAGFVWDVGSSLDDLSVLYRKNGSIASFVDPHTAEPSSTSNDEEIKARSLQSFEEDTLNSPAFRQLFDTCDAMQRSKNSGLERNTWQARQGGGVGDPFYRDPDGFEKGIQMTIEFGRSVYREKWGHRDCDIVDIGLKPDEAWKVEHDWDQPPPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R2X0</accession>
    <name>A0A3D8R2X0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VOC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_09049</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R2X0"/>
    <dbReference type="OrthoDB" id="504708at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.180.10">
        <property type="entry name" value="2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029068">
        <property type="entry name" value="Glyas_Bleomycin-R_OHBP_Dase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13669">
        <property type="entry name" value="Glyoxalase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54593">
        <property type="entry name" value="Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW68392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="203" mass="22367" checksum="90BF3AD97B070EA4" modified="2019-01-16" version="1">MATASTTTPLKPFLGNPIEICVVTKDYKRTIAGLNALAIGPWRAYTFTPANTTNQTYYGQSSAFTMKVCFADFGAAGSSHQDGRTSTPTHSHGQSGDPAPMVYEVIQPISGANIFQDFLDAHGEGIHHIAYDCNDMPFAERIRAFEARGWRFAQGGSWMGRNHFAFFVEDGPVDRTGTCFETVSFPADWDYAEPETWFPSRTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R393</accession>
    <name>A0A3D8R393_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7726 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_09154</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R393"/>
    <dbReference type="OrthoDB" id="2592504at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056143">
        <property type="entry name" value="DUF7726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42339">
        <property type="entry name" value="HISTONE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42339:SF1">
        <property type="entry name" value="HISTONE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24852">
        <property type="entry name" value="DUF7726"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7726" evidence="2">
        <location>
            <begin position="124"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7726" evidence="2">
        <location>
            <begin position="224"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW68497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="366" mass="40656" checksum="0DCE79C0159A5D96" modified="2019-01-16" version="1">MNDENNSQRLPGITTIIQAAECHNVRLPSINTHANLAATALPRPPLAVTSINAILNAPQSPNSLPKPCYSPVKPVTAITRTLPPIAPNPLHNAPAASLKRKSLSFEDDLPNDIPPDDERLQNPDQNCDQIRRKINNLINSGDMKVGEFIKTIGVNSKSYGSFMRLSGPYKGSSNGTFYNAFAFFKRRELLGIKPAKKAKVSKEEETRLLDVSSVKLDGEETMEVPVYDTCDEIRRKITAFLREPGVTQAAFLREIAKSFPDGRNSPQSKVLKDFLAKKGARAGNTSAVFYGSYVFFEKMRIRDGKPKTQLREEMERIYAGGDSDAEEGPSRRSAKGLDIKRASSGKVWCMKGDRVREDKYGRLSYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R3B2</accession>
    <name>A0A3D8R3B2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha</fullName>
            <ecNumber evidence="4">2.5.1.58</ecNumber>
            <ecNumber evidence="3">2.5.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">CAAX farnesyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FTase-alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ras proteins prenyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Type I protein geranyl-geranyltransferase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_09105</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="4"/>
    <dbReference type="EC" id="2.5.1.59" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R3B2"/>
    <dbReference type="OrthoDB" id="272289at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF1">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE_GERANYLGERANYLTRANSFERASE TYPE-1 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW68448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="501" mass="58117" checksum="B118DF16346A1A92" modified="2019-01-16" version="1">MGPKIKAQPQAVAEPAIPVEYRTVKDKLEAEYLESRPYEVLKAKKGFGGMSAAEKSAYANYIFLETGVWKNWAASQQKDFWALVEKQKIPLPLPKPQPLGKDFRGRDLETYTPQEYQEYQKKQTRLRQLEAESKRWREIHIDGDERIEEFEEEESQEVEKQRRKEIGDLRGKAMGRYESDPTWDDVKPIPQDDGEGALAQIAYTDEYSEAMGYLRAIMAANEHTPRVLGLTEHIIGMNAAHYTVWLYRASTLFALNSSIAEELKWLNEVALVNQKNYQIWHHRQLLIDQLYTTISSSPSDLEELAKSELDFMMQMFAEDSKNYHVWSYRQYLVRKLDLFSSAPELASVEALLREDVRNNSAWSHRFFIVFSNPSYCTPTSKATEPDPAIPAIVIDRELNFAKAATFEAPQNQSPWNYLRGVLRKADRKLSTEEEFASQFVQDLEEDTVDIKSSHALDFLADVWEETGEVKKADRALTLLGDTFDRVRKNYWEWRRKALKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R3H6</accession>
    <name>A0A3D8R3H6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Opioid growth factor receptor (OGFr) conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_09031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the opioid growth factor receptor family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R3H6"/>
    <dbReference type="OrthoDB" id="9030204at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140625">
        <property type="term" value="F:opioid growth factor receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006757">
        <property type="entry name" value="OGF_rcpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039574">
        <property type="entry name" value="OGFr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14015:SF2">
        <property type="entry name" value="OPIOID GROWTH FACTOR RECEPTOR (OGFR) CONSERVED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14015">
        <property type="entry name" value="OPIOID GROWTH FACTOR RECEPTOR OGFR ZETA-TYPE OPIOID RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04664">
        <property type="entry name" value="OGFr_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Opioid growth factor receptor (OGFr) conserved" evidence="2">
        <location>
            <begin position="31"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW68374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="211" mass="24676" checksum="2D2365988C98B385" modified="2019-01-16" version="1">MTSPHPIITFFRGGRDYRGRTLTQILSWTDEELEVHHDYVQTVFPLPERSGITFSAPIIDREVFETFRNDEQLRAELKRAWIRIMGFYGFKLQEDNGKHLKVTISPLFPKNSQNWLCRFDHNHLRITRVIRCLRVLGLEEEASVFHAAIKHVSEGIVGATTIAFWDRAMFSTLNNAPEEKRPGPEKGLRFLVEWEKRNNTSGLRERERQGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7J7</accession>
    <name>A0A3D8R7J7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SET domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08295</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW69898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7J7"/>
    <dbReference type="OrthoDB" id="438641at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF294">
        <property type="entry name" value="POTENTIAL PROTEIN LYSINE METHYLTRANSFERASE SET6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="17"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW69898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="356" mass="40470" checksum="65676EB49D92A05A" modified="2019-01-16" version="1">MSTAFFDATNNAQLRSYLFEVRETKSAGRGVFALQDIPKGTALIEASEPVAWVIYDEYAKEVCAQCYAYDRGRTWKMRDNAKGIVFCSHDCQVAWLTKSPEDECIAREEIQKLLKKKHKSTDQTIDKNAHRPSVEEIEQYWELAERTAQDIRAGRLSLGATKKQRKAMHNAQDAVIEEPYLMWYIFEGLVRARSDVEGWRSLKQLAVNAQPYKGLSDLARSTQVYLSLLAVVPKTFLPHVTQVLIRSLEGHSSVNVFGLRSLDERGEIGDAGSECFGYGLWPVASYWNHSCAPNVQKKRTGRMWRFWANNDIAEGQELCISYLGGDERSMEVVDRKAQLKDVWGFDCACSKCLDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7J9</accession>
    <name>A0A3D8R7J9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Vacuolar membrane protein pep3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_08420</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endomembrane system</location>
            <topology evidence="6">Peripheral membrane protein</topology>
            <orientation evidence="6">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7J9"/>
    <dbReference type="OrthoDB" id="1845386at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16462">
        <property type="entry name" value="RING-H2_Pep3p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007810">
        <property type="entry name" value="Pep3/Vps18_beta-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058919">
        <property type="entry name" value="Pep3/Vps18_RING_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF26">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05131">
        <property type="entry name" value="Pep3_Vps18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26148">
        <property type="entry name" value="VPS18_RING_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75011">
        <property type="entry name" value="3-carboxy-cis,cis-mucoante lactonizing enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pep3/Vps18 beta-propeller" evidence="10">
        <location>
            <begin position="24"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="7">
        <location>
            <begin position="628"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="domain" description="Pep3/Vps18 RING C-terminal" evidence="11">
        <location>
            <begin position="859"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="814"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="242"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF26148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW70023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="966" mass="108165" checksum="766A8350584886CD" modified="2019-01-16" version="1">MALDASNGYVAAPSLQNLNEIALPIFNVERVQLQFSIASDFVAAQVANNVLILALSNGRILRIDLDSPEDIDDIDLPKKTSEVGVIKRMFLDPTASHLIICTALGENYYLHSQSRQPRPLSRLRGVPIESIAWNPSLPTASTREILIGASDGNIYEGYIETSTEFYRKEDKYLKLLQRIPEGAVTGLWVDLVAGKPDFRRVLVATQSRLIHLSGRIGRVAHEGGASIFTKLFENEQPTIYESSSVSGAPSSLVVSPDHPDAASPESLNPDRIFAWLSSQGVYHGRLLTTPATPELGTKVFAEAKMLPRSQIPASEYASGRKKPIPELVDSIALTQWHILILVGSRVVAVNRLDDRVVFDQVVLESGQQALGLYADQQKNTFWLFTTQEILEIVVTDEDRDVWKVMLETEHFDAALRYAKGPAQKDAVATASGDYLVSKGAFLEAAGVYGKSSKPFEQVALTFIDNEQQDALRKYLLTKITTFKKSSIMQRIMLASWLVEIFMSKLNSLDDTIVTKAELSETLNPAQTKDQLDSIRTEFQDFVVKYRSDLDKKTTYDIISSHGREDELLYYANAVNDYNYVLNYWMQRERWRDALSVLKKQTAPETFYQYTSGLINHVATDLVDILMRHPDLKARNLIPALLDYNRNFKGSLAQNQAVRYLLHVINQLNSTDAAVHNTLISIYASHPSKDESGLLSYLESQGDEPSFDSDFALRLCIQHSRVQSCVHIYSTMGQYLQAVELALDHDEIDLASLIADRPTTNAALRKKLWLAVAKKVISQTNGIKTAIEFLKRCDLLKIEDLIPFFPDFVVIDDFKEEICSALEDYSRNIDALKKEMDESSQTATNIKIDIAALDHRYAIVEPGEKCYVCELPLLSRQFFVFPCQHAFHSDCLGRKVMEQVGVATGKRIREVQGLISKGMVTGARRDAAIAELDGLVASACILCSDFAIKRIDEPFVLPTDNRDEWAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7V4</accession>
    <name>A0A3D8R7V4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BP5796_08417</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="341578at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009893">
        <property type="term" value="P:positive regulation of metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14012">
        <property type="entry name" value="PK_eIF2AK_GCN2_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23823">
        <property type="entry name" value="RWD_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14046">
        <property type="entry name" value="STKc_EIF2AK4_GCN2_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000050">
        <property type="entry name" value="eIF-2-alpha kinase GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000379">
        <property type="entry name" value="eIF-2-alpha kinase GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000009">
        <property type="entry name" value="Eukaryotic translation initiation factor 2-alpha kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000821">
        <property type="entry name" value="Serine/threonine-protein kinase gcn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000074">
        <property type="entry name" value="Serine/threonine-protein kinase gcn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016255">
        <property type="entry name" value="Gcn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024435">
        <property type="entry name" value="HisRS-related_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF136">
        <property type="entry name" value="EIF-2-ALPHA KINASE GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12745">
        <property type="entry name" value="HGTP_anticodon2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000660">
        <property type="entry name" value="Ser/Thr_PK_GCN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00591">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RWD" evidence="16">
        <location>
            <begin position="44"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="270"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="596"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="665"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="717"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1462"/>
            <end position="1492"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="163"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="665"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="723"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="822"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="602"/>
            <end position="610"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="625"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="626"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000660-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000660-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDW70020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1607" mass="180436" checksum="07A49C49A2A097B7" modified="2019-01-16" version="1">MPPSSPWGKKPNKENTSQSGFPKLKSGNPNNDVPKSQYEEIQEDELVALEAIYAEDFKQIQKSHGAWKKSEPSFEIRIKSSDEDIAITLCATLTATYPKTIPLLSLKDHDFLREGTLFKVQKVMETKPKELVVEVQPMIMEIVDAIRDVLEDAAEAKAAGRELPSLEEERATHEAAAAKVAEEEKVEQENQKRLESLEDQRMLDNLVQDELKRREAKVKEAKRKTKPPPLLSEVSYEKVSKGDATQDVLAFDQPITFCEGSEDPILFQLVTSKVRIRKGPISVCYTVRPIVVEGSGQVPTLALKETGLAAGVKDYNNFKKQLQALEKELEAQKQVRHRNILEIFDFKVYKTADCAVESDSGWTVSILTEYAGKGSLEELLDITGTLGVEKVRSWTIELLDALRFLHQAGLLHEDIHCGNVMIFRDSEGEIRPKLADAGYQRKLYSLSGKKHLTTTMSVAKSAYWCPPEIANTDQPQYTQKTDVWDFGLLFLQMLFGLTVVQKYASPLALAEALALSDSLHEFVQKLFKADPKKRPRAFELTSSEFLATDAPILDEDSSALASRLGSMTSLLPATPGRRRHDSMNSHGPYSRYKEDFVEEGRLGKGGFGEVVKARKKLDGQIYAIKKITQKSSSSLTEVLKEVRLLSQLSHPSVVRYYNTWTEEVLDGSETEDDTTEDAITEQSPSELSHGTGPNIDFGASTGGLDFMSSSGFPQVEFGYDSDSGSEEEDDDLDRESTSPDDEVANGGSAGNQLVLNRTKSSSRFQRPFKTILYISMEYCEKRTLRDLIKRGLYKDNDEIWRLFRQVLEGLVHIHGLNVVHRDLKPENIFIDGASNVRIGDFGLATSGQYSVVDRNSSAAIHISGDLTRSVGTATYVAPEVRSAAGGVYSSKVDMYSLGIIFFEMCYRPVTTGMERDVVVKGLRQKEPALPSDFETTEKAVQTDIILSLIVHSPKERPSSAELLHSGKLPVQMESETIRQTLAGLSDSRSPYYHKMMSALFSRPTKQAKDVAWDMSTTNPSAADLLLQGIVRRKLISIFRRHGAVETPRSVLFPRSGHYGPNAVQLLDPTGTLLQLPYDLTLPHARAIAKQEPAVQKSFAFGQVYRDRHDGGQPQTFGEVDFDIVSADSLDLALKEAEVIKVLDEVVLGFPALGSTQMCFHLNHSDLLTLIFDFCRIEPGVRQAVAETLSKLNVQHWTWQKIRTELRSPLIGVSATSVDDLQRFDFRDSPSKAFQKLKTIFEGTDNFEKASSTIAHLRDVIAYTKRFDVRSKIYITPLGSLREKFYKGGVLFSCLYDRKIRDVFAAGGRYDSLIREHRHRTGSTDDDRHGVGFNLAWEKLARLPKPSAKGFLKKAEEEVHGIWNTKRCDVLVASFDASILRTTGVDIVQNLWAHEVNAELARDARSPEDLLSKYRDDHHSWIVIIKQDSVLKVKSMDRKDIQDTEIPSTQLISWLRGEIREREQREGLQQPQRSKLLRNPSQPDTTNNDHEQEVRVLMAGTKSKKSNRRNIVEQAQGRAASLVQSFLDGPIAAIETTDHVLELIRETRLSDPETWRKVTHSVPTAERRYIGEIHDMMSGLAHQNKDITRNAFIYNFRTGMCIYYDLAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8E7</accession>
    <name>A0A3D8R8E7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_08511</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8E7"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF11">
        <property type="entry name" value="HET-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="4">
        <location>
            <begin position="261"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="827"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="869"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="911"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW70114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="997" mass="112012" checksum="6AF3C6B02EF6CBA8" modified="2019-01-16" version="1">MHLLERNSAGKFSLTAFVCDNITPYAILSHTWGSDTDEPTFQDLMLGTGSSKAGYSKIRFSLSFRRLSTRCFTGTRNAAKCYVYLSDVSNRKRKASNQCSEHTWGAAFRSSKWFTRGWTLQELLAPGPDSILFFSYERDLIGDKRILEQEISEITRIPITALRGTPLSQFEVNDRSLWAKDRQTKRKEDEVYSLFGIFDIQLPLHYGEGRDKAFTRLREEIDEPLKVVLDKLRSVDNAMFDSHDEEHNARCYPSKRVGLLQQVKTWASDGGSECIFWLNGMAGTGKSTISRTVAQNFADKGELGASFFFKRGEGDRGHARFFITTIATQLARKVPSLTLHVKNAIEADPAISQKAIRQQFETLLLQPLSKMRNSFQESLRIVIIIDALDECDCEEEISIIISLLPQVKHISSVQLKVFLTSRPELPVRLGFEDISGKYKGLVLQEIPKPIIRDDILVFLEHELAIIRDDYYKSVKTIRRQLPFDWPGRANVQILVEMAIPLFILATTICRFINDRRCGQPNDQLTKVLKYQTKSQASKLDATYLPVLIQLIVGVTQSEKRSIVEEFQQVVGSIVILASPLPATSLDRLLSVSEGTVDSRTDLLHSVLSIPSDPDHPIRLLHLSFRDFLLDSEKCEINPFWVEEKQAHQRIFDCCIQLMSSFLKKDICGLEAPGVHVEDVTSSQVDRCLPSEVRYAYLYWIQHLQSSGAQLHDNQQVHHFLKVHLLHWLEALGWIGKISEGILAIISLEEQISVDKSPILYTMIRDIKRFALHSREVIEQAPLQLYCSALVFAPKKSVIRRQFEGYIPTWIEPKPKVQASWDATLQIIAGHSRAAISVAFSPDGKQVVSGSHDNTVRLWDATTGAQLQTLAGHSSGVIFVAFSPDGKQVVSGSHDNTVRLWNTTTGAELQTLVGHSDVIRSVAFSPDGKQVVSGSNDNTIRLWDATTGAQLQKYAGHSSGVMSVAFSPDDKQLPTLLVSNDWIVKGGGKFSGYLLMTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8S7</accession>
    <name>A0A3D8R8S7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent rRNA helicase RRP3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">ATP-dependent rRNA helicase rrp3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BP5796_08757</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8S7"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010467">
        <property type="term" value="P:gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17954">
        <property type="entry name" value="DEADc_DDX47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044765">
        <property type="entry name" value="DDX47/Rrp3_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 13 18" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="17">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="86"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="281"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="441"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="12">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="25"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="441"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024398"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDW70360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="483" mass="52964" checksum="5DE67359D230CCEF" modified="2019-01-16" version="1">MSSVKRRKVDGDVPSGLVKKSKKTAPAVESDSESPASPEPAAAESEAPAEETPLKTFKDLGIIDSLCDACTSLGYKNPTPIQAESIPLALQGRDLIGLAETGSGKTAAFALPILQALLDKPQPLFGLILAPTRELAYQISQQFEALGSLISVRCAVIVGGMDMVPQAIALGKKPHIVVATPGRLLDHLENTKGFSLRSLKYLVMDEADRLLDLDFGPILDKILKVLPRERRTYLFSATISSKVESLQRASLRDPLRVSISTSKYQTVSTLLQSYIFIPHPHKDTYLVYLLNEFAGQSAIIFTRTVNETQRLAILLRTLGFGAIPLHGQLSQSSRLGALNKFRAGSREILVATDVAARGLDIPSVDVVLNYDLPPDSKTYIHRVGRTARAGKSGHAISIVTQYDVEIWLRIEAALGKKQKEYEAVKDEVMVFKARVEEAQRHARNEMKNLHEDRGKKGATLKGRRPKDVKGGKRGRDEMDREEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCZ8</accession>
    <name>A0A3D8RCZ8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 8">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="6 8">3.13.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_07961</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine</text>
            <dbReference type="Rhea" id="RHEA:21708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.13.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7 8">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="7 8">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.13.2.1" evidence="6 8"/>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RCZ8"/>
    <dbReference type="OrthoDB" id="10007170at2759"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033353">
        <property type="term" value="P:S-adenosylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004005">
        <property type="entry name" value="PRK05476.2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420:SF0">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="3 8" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S-adenosyl-L-homocysteine hydrolase NAD binding" evidence="10">
        <location>
            <begin position="151"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="117"/>
            <end position="119"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="182"/>
            <end position="187"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="259"/>
            <end position="261"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="306"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW71927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="406" mass="44452" checksum="732F07871B40FB27" modified="2019-01-16" version="1">MSAPASKFKVADISLAAFGRKEIELAENEMPGLMATREKYAADQPLKGARIAGCVPVFAWKGETEEEYQWCLEQQLVAFKDNKGLNLILDDGGDLTALVHEKYPEMLKDCYGVSEETTTGVHHLYKMLKNKALLVPSINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAMALHGMGARVIVTEIDPINALQAAVSGYQVMSMEKAASIGQIFVTTTGCRDILVGEHFEAMPNDAIVCNIGHFDIEIDVAWLKKNAASVQNIKPQVDRYLMKSGRHIILLAEGRLVNLGCATGHSSFVMSCSFTNQVLAQILLFKSNDEAFGKKYVEFGKTQKLEVGVYVLPKILDETVAKLHLAHVNAELSKLTSVQAEYLGLEVEGPFKSELYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RD07</accession>
    <name>A0A3D8RD07_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_07977</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RD07"/>
    <dbReference type="OrthoDB" id="63112at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030681">
        <property type="term" value="C:multimeric ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000171">
        <property type="term" value="F:ribonuclease MRP activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004526">
        <property type="term" value="F:ribonuclease P activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013893">
        <property type="entry name" value="RNase_P_Rpp40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15396">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15396:SF1">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08584">
        <property type="entry name" value="Ribonuc_P_40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW71943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="331" mass="37662" checksum="B6CB6971986D87B2" modified="2019-01-16" version="1">MGHLDPKQPPVKRKPYAAILDHHFVQKVEILLPEELYEIIKGTLLTERLRPTYSRVILPLTAIVEGEFFTEYIKRGNILMFSEGRIGVDNVYTLREGALTLHLDKESYERAGLVGKPDVVTGKRGTRPRWVVEIDLRQPSMLHGKKGFDRIVYAFKNVLTTPVTWLFCDLAEDSPSPDPLQPHFPTRITADFEALRFSAALPPLSPPAKMDTNHGEEFEDFAVETHEWLSLAALASQRINPTDNVDPYLCRYNPPKPTTTKDLVKIVWKGFISPSWAHRKFVQALLTMPKNGWFAYSVASFGEDWSGESKNCTILKVPDAANEYILWEVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDM0</accession>
    <name>A0A3D8RDM0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_08156</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDM0"/>
    <dbReference type="OrthoDB" id="6079484at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW72122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="137" mass="15349" checksum="89F27A39B0EFE26C" modified="2019-01-16" version="1">MSGSGGYYKYRCKYWLTFNCPHWVWVNNAPCAHCLADGRESDVSVISTASIHVARDICVPQIEHGTFHYALKEIVCAGDCDTRWLIEGSSLNAFPTSTENPAATFPALERLRVKSMEKKFKAQQESPLWTGGSFNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDR4</accession>
    <name>A0A3D8RDR4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Intracellular protein transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_08092</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDR4"/>
    <dbReference type="OrthoDB" id="198977at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048211">
        <property type="term" value="P:Golgi vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000296">
        <property type="entry name" value="Related to transport protein USO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006955">
        <property type="entry name" value="Uso1_p115_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024095">
        <property type="entry name" value="Vesicle_P115"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006953">
        <property type="entry name" value="Vesicle_Uso1_P115_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10013:SF0">
        <property type="entry name" value="GENERAL VESICULAR TRANSPORT FACTOR P115"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04871">
        <property type="entry name" value="Uso1_p115_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04869">
        <property type="entry name" value="Uso1_p115_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vesicle tethering protein Uso1/P115-like head" evidence="5">
        <location>
            <begin position="339"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="Uso1/p115-like vesicle tethering protein C-terminal" evidence="6">
        <location>
            <begin position="840"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="887"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="934"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="887"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="941"/>
            <end position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW72058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="972" mass="108016" checksum="D743583275AFE237" modified="2019-01-16" version="1">MFAIATTPAKQSVSETITTLSGRLSSSTLLEDRRAAILGLRSFAKEYPASVASDALRGLIGSLRKDGEDVDTVKVVLETLLMLFNPNENSPEASEEIALWLADEFTQRQDNITLLLDFLDTSDFYSRLYSLQLLSAILSSRTERTEECIFTAPLGISRLVAVLDDRRDVIRNEGLSLLTYLTPNSAELQKLVAFENAFDRIFNIIKQEGSIAQGDRPVEDCLILLANLLRLNVSNQSFFRETGCVVKLARLLNDVLEDQKTDGEVAEWVQIQKNRNIYALLAVLRLFLIPGGAGTQANQASFWQHGVLGLVLQLAFSRSTEMQIKAEALITCADCIRGNSQLQEAFAPLQVTSVLDEPMDGANGDAKLNGLPKVYVIDGLLDLTLSVSMLSAFDTRLAACELIKAYFYNHPAIRLHFLRRAIEGHTSGTDETANVLTMLLQPLEDNVTGDPYRHWFAAVIVFHLIFEDLEAKSLAMSVVEGDASSGEEVVTCIQTVAANLITAIQKNADERVIVAYLMLLCGWLFEDPDGVNDFLGEGSNLQGLVQGVLQPVGDMGVVQGLCALLLGIVYEFSTKDSPIPRTTIHPILSSRMGRDQYVDRLTKLRAHPMLRDFEVLPQKLNSAPVGGLPEVFFDKAFVDFAKDNFSRLLRAIDRDPGMEVSIIANGVQKGISRDLVDSLRAQLEEKEKTVQNNAEQLISLGRQLGQEQADHRRAKETAAVELARIGNVNDALQRHHDEDIRKLRAEMARLTQDHQTQLERVQQTSDANMTRARQQLEEELAKLGHEHSRTVEDYKRQLEHALKSGEANTERARRRADAEIADLRGTISSLEADISKANKNHALELQAMQEQSSSKLSDLSRQLASSQSILKEKETRITELEAQAKAEKEKAAKAGEYVTSKEEEKQALQSEMDDFLLLFGDMEEKVSKYKAQLKSLGETVSDGEEDGDDDEDEEAEDGENEEDDDEDEDEVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDY9</accession>
    <name>A0A3D8RDY9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein arginine N-methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_08118</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDY9"/>
    <dbReference type="OrthoDB" id="1368803at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000018">
        <property type="entry name" value="Protein arginine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000149">
        <property type="entry name" value="Protein arginine N-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007857">
        <property type="entry name" value="Arg_MeTrfase_PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035075">
        <property type="entry name" value="PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035248">
        <property type="entry name" value="PRMT5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035247">
        <property type="entry name" value="PRMT5_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738:SF0">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05185">
        <property type="entry name" value="PRMT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17286">
        <property type="entry name" value="PRMT5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17285">
        <property type="entry name" value="PRMT5_TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015894">
        <property type="entry name" value="Skb1_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRMT5 TIM barrel" evidence="11">
        <location>
            <begin position="47"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 arginine-N-methyltransferase" evidence="10">
        <location>
            <begin position="392"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 oligomerisation" evidence="12">
        <location>
            <begin position="592"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="76"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="327"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="9">
        <location>
            <begin position="89"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="357"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="559"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="568"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="427"/>
            <end position="428"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="516"/>
            <end position="517"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="site" description="Critical for specifying symmetric addition of methyl groups" evidence="7">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR015894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR015894-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW72084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="817" mass="89365" checksum="BC6E3286D021DF09" modified="2019-01-16" version="1">MASEQQNSAAMADNPDDFTPTFYVGHHESRRPLPVTDFVLRQAQDVGYDMLTSPITSPYFHSRVLTLLSTHLAELQAAESPDSRNSTTPPAPIIPPLAPVDTPLTPGDTVSQLIACVSPWIDLCSADPLISNISRQVLNIEIAYAAFCGISNIIIPGPRSYSSSASDYDGLTQYARAIQEALTIGGYMQMAISIPMYGPEETKEMTGDLVPLARTSPTAGKSKAKDIDLFESWDAWNLIRSVCKYNARLSVALGLPRQLPTESLQSRWFAEPLRILTFTPNTFLKNKGGHPVLSKNHQHLIARYMRLKQSPWLMLCDVGPIPGLDDPSALTQTADGFPSPSAVDDVSQTTSPTPAEAMEHAQRPTSKLKDPAAHLIYIRWLQRHQPIRTTIERFGAGYQDYLQAPLQPLTDNLESVTYEVFEKDPVKYDWYERAIAQALQDWSEKRKPTSSASGAVVVAVAGSGRGPLVTRALKASATTGVPVEVWAVEKNPNAYVLLQRHNEEDWGGVVNVVKSDMRAWKGPLRSGGQIGQAVATGKDLPPQNIPATPYGKVDILVSELLGSFADNELSPECLDGVQHVLAPQYGISIPSSYTAHLTPILAPRLHADISHRAITDDTATDTPYVVLLHAIDYLATSVPDHPRIQQSWEFVHPLPSTTLNIAEARRGGGVSGGGGGSMSGGDGANEHNTRFAKHKFICKDRGVVHGLAGYFEAVLYDGSVAGGSSAEAAKVELSTRPDTIDAKSKDMISWFPIFFPLKSPLYYADDSELEVSIWRQTDDRKVWYEWLVEAFVMVGPERRLRTGRSEMGSSRKVGCLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RI35</accession>
    <name>A0A3D8RI35_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_07145</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RI35"/>
    <dbReference type="OrthoDB" id="19981at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021013">
        <property type="entry name" value="ATPase_Vma12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31394:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 199"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11712">
        <property type="entry name" value="Vma12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="217"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="274"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="8"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="284"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW73703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="301" mass="33570" checksum="429930907BD63616" modified="2019-01-16" version="1">MTTSMVEALEKLQSLEHPHVADTEAKSEDSTCAEEQLSPDDAAPTREQRHAIENTIQSEHDNLDELMGNPEVGKPISHGQILEISRNLKLQGVTLFSLDVLLRGSKVYIAPPKPKAEPTPEYKALMARLRREEEIREYERMINPPPPMETFNQRFPTSSAAYAFSSNHETKEDTEDDLTYADVDRQITLILNVLVSIVACAGGIWVIARWWSTPARLAVSMLGSLLVGVAEVVVYMGYIRRIGDAKGKAKKLNEVKEVINTWVVGAGEEFEDADSQNPTVLIESKPEGKENTARQRKKDTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIG4</accession>
    <name>A0A3D8RIG4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD40 repeat-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_07188</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIG4"/>
    <dbReference type="OrthoDB" id="1930760at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061685">
        <property type="term" value="F:diphthine methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052415">
        <property type="entry name" value="Diphthine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042:SF1">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="47"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="50"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00043952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW73746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="45296" checksum="697D69289844FBF5" modified="2019-01-16" version="1">MASQEEAGSSDPITHLCSTVLDLPPSCIEFSLEAPQYFVVGTYNLQREEPGDEGETGDGDEDGVNDRVEKKQQSRDGSLIVFKLDGETLSLIQTESVPSAILDLHFSPHVPSTLCIVTSTGTLSTYSLSPIAATSSEPTTSIDHTLQHISTTQLFSTDTIITSFVFHPSDPELIAVTLTTGAVHLIRNLAPQSPSTSPPTISAPVITHSLEAWHGVFTPPPSQTIYSGGDDAKLRFVTFATLPQTEQDVDDISTAIVAASPPNGYRGHEAGVTFILPVPCTQGEPQLLLTGSYDDHIRLLSHAQNRVQVLSELDLGGGVWRLKFLDPVEPAAEATQGRRYRILASCMHAGTRVLLLSQGPEGDWGFEILGRVEKHKSMNYGSDFQPIMVEGEDEIRDRRVIVSTSFYDRLLCVWRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJ86</accession>
    <name>A0A3D8RJ86_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Proline dehydrogenase</fullName>
            <ecNumber evidence="2 5">1.5.5.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_07547</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Converts proline to delta-1-pyrroline-5-carboxylate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23784"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17388"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.5.5.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proline oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.5.2" evidence="2 5"/>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJ86"/>
    <dbReference type="OrthoDB" id="5464at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004657">
        <property type="term" value="F:proline dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010133">
        <property type="term" value="P:L-proline catabolic process to L-glutamate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029041">
        <property type="entry name" value="FAD-linked_oxidoreductase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002872">
        <property type="entry name" value="Proline_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015659">
        <property type="entry name" value="Proline_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914:SF34">
        <property type="entry name" value="PROLINE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13914">
        <property type="entry name" value="PROLINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01619">
        <property type="entry name" value="Pro_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51730">
        <property type="entry name" value="FAD-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5" id="KW-0642">Proline metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proline dehydrogenase" evidence="6">
        <location>
            <begin position="72"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW74105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="417" mass="45992" checksum="84E0798C9E8A293E" modified="2019-01-16" version="1">MRLPTSNLIRSLFLGALFKSPVLFNIGLAFLKKVASSESPMLNPDKNILLRAIVRPIVYDQFCAGTNRVEVQRTVSDMKEMGFSGVILCYGKELVVDKNTPDSTSQSLQDQSKTQIDNWRDGNLETLRMIGAGDYLGIKVTGAGPAITRALSKGEDPPQELSLALDSICQQAAAQKTRLWIDAEQQALQPTIDNWTIDLMRRHNHNGEALVSNTLQAYLKSSRVSLARQLRLAQSENWSLGIKLVRGAYIGSDPRDRIHDTKEETDACYNGIAKDVLSRSFPGFTKEDFPAVHIFLADHNSESIRMAANLASDLALSGDLKNAPCFGLLQGMADDISCELLSVGENAKDIKAKTKEEVDAQKMAAPQVYKCLTWGTVQECMQYLVRRAVENQGATGRMGEGVAGIKSELRRRIRRGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJP0</accession>
    <name>A0A3D8RJP0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_07632</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJP0"/>
    <dbReference type="OrthoDB" id="8300194at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33112:SF16">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="75"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW74190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="564" mass="63601" checksum="97F31CFE0557EA93" modified="2019-01-16" version="1">MATSCSSPVPAGSPVESEWYPCVMAKLISSWLNACTENHVLCKPPSPSKLPKRLLDVLSRDNPFLLETNGEEGPYLALSYCWGKQRKLALMTFGPNSRGKRGQPDPTPNIEAHKTNIPFAAMPKTLQDAVTTTRQLGFRYLWIDALCIIQGDEDEWQHQHPLLADVYLNARLVLAADSAVDQESGFLQQLSTVVRPDTRHLESRWTQALADQHLEQNAREESSTRCPSPLNWDEPLNQRAWSLSEAIFANRIVHFTSLGMVWECNEIRECEKGCVQTLQEDDTDSFRLFRDVAIAKDCTPVELYRKWDTVVEHFTRRNINSHPDETYKDSLKLVALARMAGKFSQILEQVLGRDDRYLAGIWRDNLASSLLWTTDARADGNLTAKWRRPEAPRAPTWSWASIEGPVFFNQLEDYRPAIIIDDASVEYCNPCDEFGQVLSGSLAVQGRLLHGLKIQRESLPDSNGIAERHVKISPSTPYIDLHFSCDVPLSESELGHEYSCLYLGRGEVGVATDEGTRTYWACLLLRPVPNKSKVFERAGVSCRSRSADTSTYFGNSTYESIEII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RNK5</accession>
    <name>A0A3D8RNK5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative TSR1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_06468</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RNK5"/>
    <dbReference type="OrthoDB" id="119302at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF1">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22298">
        <property type="entry name" value="Tsr1_G-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="6">
        <location>
            <begin position="86"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="30"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW75647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="820" mass="92224" checksum="CCD770507ED83A58" modified="2019-01-16" version="1">MPSSVTSHSHRSTTKASHKPFKSRKATKGALKEASKGKVEDLSHRKTPHQQLMSKFDRRNQARQKQQTKHREHLKETSVFAGRDGAPRIVAVIPLCDDCDAAAAVRTLSGSLDIEAEVPEEGLLRTDIDRFKQKIEYVILQRDLLSCIDAGKVADFVVLILSPDQEVDELGELIIRSVESQGLSTLLTVVQGLDKIEPAKRRPQVLGSLKSYITHFHPEQEKVHNLDSRQECANLMRSLCTTTPKGIRWREDRSWMLIDEVQWPSAEGENVVVTGVVRGRGLKADRLVQVGDWGDFQIEKISAAPLSSKKRRADDMAVDEAEGEKILETPTDDQDDLLELAPEEIMMEDIDTDPAISVAATEKRGVLLDDHHYFSDDETHMPAVPKRLPKGTSAYQAAWFLGDNFSDSGSDLEDMDYQADVSMDTPALPQDGVEGFAPREPTEFAPSEYPQSEMFLDPNVDDEEEAEQLAQFRARKGDEAEDDKEFPDEVELHPHVLARERLARYRGLKSLRTSRWEEDEDKAHEPEEWRRLLQVPDYKSSRSQVTREALVGGVAPGTRVHIYLRDVPSSLQATYNSNQPLTIFSLLRHEHKRAVLNFNITLSSDFPEPIKSKTEMVMQCGPRRFVINPLFSQGGNTSNDVHKFDRYLHPGGSAVATFVGPLTWGSVPTLFFTRTVSGSVAPLNLVATGTSLPPSSSRVIAKRIILTGHPYKIHKKLVTIRYMFFNREDVEWFKALQLWTRRGRSGYIKESLGTHGYFKATFDGKINPQDSVGVSLYKRMWPRDARAWNVTEVVEESAGDFKDVAMDEFEAPDAEGGVVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RNR5</accession>
    <name>A0A3D8RNR5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Urease accessory protein ureG</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_06466</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RNR5"/>
    <dbReference type="OrthoDB" id="10063137at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016151">
        <property type="term" value="F:nickel cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043419">
        <property type="term" value="P:urea catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05540">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000208">
        <property type="entry name" value="Urease accessory protein UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01389">
        <property type="entry name" value="UreG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004400">
        <property type="entry name" value="UreG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00101">
        <property type="entry name" value="ureG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31715:SF0">
        <property type="entry name" value="UREASE ACCESSORY PROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0996">Nickel insertion</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="7">
        <location>
            <begin position="52"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW75645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="268" mass="28620" checksum="EBE82AC9B99B470C" modified="2019-01-16" version="1">MSHSHDGVHSHSHDQAAADHGHTHEILDGPGSYMGREMPIIEGRDWSERAFTVGIGGPVGSGKTALMLALCHALRERYSIAAVTNDIFTREDAEFLTKHKALPASRIRAIETGGCPHAAVREDISANLAALEDLHREFQSDILLIESGGDNLAANYSRELADYIIYVIDVSGGDKIPRKGGPGITQSDLLIVNKTDLAEIVGADLDVMDRDARKMREGGPTVFAQVKKGVGMEHIVGLIESAWKGSGAQATSQARGGPTGTPGLEELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RNU7</accession>
    <name>A0A3D8RNU7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Rxt3-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_06558</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RNU7"/>
    <dbReference type="OrthoDB" id="3596986at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013951">
        <property type="entry name" value="Rxt3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF8">
        <property type="entry name" value="PAXILLIN, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08642">
        <property type="entry name" value="Rxt3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="813"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1021"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="455"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="478"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="615"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="666"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="754"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="821"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1068"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1089"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1100"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1135"/>
            <end position="1149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW75737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1149" mass="127304" checksum="CDE56293657B9BE9" modified="2019-01-16" version="1">MDPRQPPQHPFSRSTASPYGRAPFPPSANPPPFPPSSHAPNAPPTYTEHQRRPSGPPYYPEQRGYAQDGAQMPASSTGQGHSRHPSSSSIGHGTPVNRSMPPPSSPQQQTSQQAPHHPYGPPPPRPPPVSVGPPAAFPSGRELPSLASLAGRASSTNMSISSMLGESRGPPPPPPSQYTSPITTNAPPPSGMYAGTTHASPRVNSSRPDYPPFSRRPQTPEHPRPYDPHDRRANSAGSPPSAAALTPEMRRWGTPQTYGQRPPPERGLPPVEERREPIRVANPNVPPRPSSQPTAFNPPPSRIPDSVRPPGQNEVPFGRREEQMPRADQGRQEPPYQRPSTFSNSDNPVYAYAERERQEREAQMRREQDRERAREQEREQRDRAIFEHRLRQQQEHEIQLAQRNSQNAQSRAPESRDPPAWMRPDYAPRPAYDQAPEQRPTPSQPGSSNYDHPRSSAPPYSSHAAYAWTDPRYPPTSQPSSQPQQRAPGPAPAPAPISHHETVLQERLERQRSINEQQRHQEEMMYGRPSQRPQYLSHESPNRRPQEEPPSTQQRFLGIQELNRKGRVSPLPQAVQGAQAQIGTPGGEPGIKSEFGRMFSGIGSGVGGGLSTSSPAPNGPSNLPFTSVAQLRKEDLEASEAQDSPIENGSHPIARTASQGDRRRKLKDEDARGDDDSTGRQTPSGNGKRQKRHHRYKPKHSDLRTLLTSTSHHHHRLEEQASSPSQSSLTPFKSIKGASGFPSPPGESKAPPNLHHHHVQVRHHHPSQAKAPAPPVNTIEPLPKTKIRSNAVLDSVSHLPRRHLGHEYYQPVLKPGKFSRSDNPNRGFASTPTPLPRFDGNENCTFTIRVARIHLSSVSREEITARRAVWGTDVYTDDSDVVAACIHQGWFLGEWAEDIDKSLLNLEIGKPRNAGERIVYPDTLEEPPARGPMPVRQNRDLHVTVLILPALEKYSSLTRFGMKSREWGHKHDGYTGIHDGLSFMIQKISWVDGVDSYEERNEGKKMKLRPNVNIEDMEAEYEASQRTDGNEDGDLVESFERGGPGPLDPDLGTIKAAGRNWWKKSKDKSKGTTTEKRVSIQKPLSDAADEGKEKAKETEQATTAPVSPPQQTNGGAVRSGSGSETSQTARSTPKPLKERLSDMFKREDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPA7</accession>
    <name>A0A3D8RPA7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nicotinamide riboside kinase 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_06462</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPA7"/>
    <dbReference type="OrthoDB" id="10041966at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02024">
        <property type="entry name" value="NRK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002607">
        <property type="entry name" value="Nicotinamide riboside kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW75641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="259" mass="29090" checksum="59E6FF1B727A6615" modified="2019-01-16" version="1">MAAPRKAVVLGISGCSSSGKTTLSRLLRDIFPNTFVLHEDDFYRPETELPKKDDLLDWDCAESLNIPDIVTSLEHIREKGTFPPNLDSKEDQNSVGECPVSDVVIESLKAKVTAWTQPGGPGYGILAGTEEPVRLCVFDGFLLYSHSMASVQPQMDIKLFLRVSYAKAKARREARSGYVTLEGFWEDPPGYVDKIVWPNYVEDHKWMFEDGDVEGRVKEDVLSKWNIRCQDGLDMDMTTTLKWAVDLIMEALPNLVASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPK4</accession>
    <name>A0A3D8RPK4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative dibenzothiophene desulfurization enzyme A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_06800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPK4"/>
    <dbReference type="OrthoDB" id="5561043at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF30">
        <property type="entry name" value="XENOBIOTIC COMPOUND MONOOXYGENASE, DSZA FAMILY (AFU_ORTHOLOGUE AFUA_6G01920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="2">
        <location>
            <begin position="34"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW75979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="501" mass="54660" checksum="19ED2F93BFF86E95" modified="2019-01-16" version="1">MVPATTPAKKRIYLNFFDFFNAGNHMSPGQWLDPADKCYTKDRLPYWLNLARLAEEGKISFIFLADTYAGHEVYGGTLEPQLRSSAQAAVMDPFLVVPAMASVTKTVGFGVTGSTSYLNPYILARSLSSLDHLTEGRVAWNVVTSWSQSTADALGASGVVAHDERYAIAQEYMDVCYKLWESSWSDDAVVRNIETRTAFDYHQIKRIQHEGKYLKTNAPHQTHPSPQRTPVLFQAGTSKLGRQFASKHAECIYIGGLVPSSSAADVAAIRALAAASGRDPASLKFFVGISPIIGKTLEEAQAKYERARQNADFIGGLSQFSGYTGIDLSRFPVDDVFDLKDAPNDMAVHGILNAFNKASGSETQWTPRMLGEKMALGGLHPAPVGTPEMVADVFEEWIDGCDVDGFNISYTTSPGSFEDVVYLLRPELVKRGLMWEDYDVPGGTLRENLLGKGMCRLPEEHYGSRFKWGRGGEVMKDDGDVVKPHVNGAGASTLSAAGGTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPY6</accession>
    <name>A0A3D8RPY6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_06944</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPY6"/>
    <dbReference type="OrthoDB" id="4456959at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF4">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="113"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="673"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="693"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="735"/>
            <end position="753"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW76123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="885" mass="98782" checksum="7451741385A68600" modified="2019-01-16" version="1">MPTKRKSSADLHSSASKQQKTEHVKECSRTVKKRLQSSNRTGQACDRCKVRKIRCDGLSGACSNCLQNGNECMVTDRSTGEAYRRGYVQELEEEREILRQQVQDLEERLVQHGIEPQTYNKYDATSTSDHDDSPSTTSTNLEATPNQLRQNSIEAKDPPKDLPAFRASCRGDNYLGVSPGGSLSLSSIRGTALSILGMDIDIADFQSQDMDEPDPSASQPRLYNKSYQAFLQSSLGVNHRIDNLELPKREIGMTYIEWYFGAIAPYIPFLHKPTVVKLAARMYDDLSFVPTAAETVIVHMIMAVICFQFGTRNSETPGESEKKNSQSNLHYHFCLSKFYDLVSSHTFQDVQALTLICAHLRNFPKPGASWIMTQTTMALAIELGLHRSAKRWASCSMPSALEIEMRKRTFWSLLAIDITLSGKLGRPMTFRTEDFDVELPEPIDDELLSENGLDESRPGKCGHLVGLAAYRILPLFNELYNTIYAVRRRPDLYESQVLRLEALLKKWQEELPEELVNGDAGVGISDGQVFALYTQVWALEFRLLLRHPSVSQTKDQEFEAANLRICVETARKMLIVVKALGEHKSLDTTWYNSTVYVMAITTTLFNQFQKRGESSAADLASVKGEMNMWLDIMGDVGKLLGSGTRLRDAVRVVIEGTLALLDKRVLPTRLPTLPASSQYMDSDNIKNEPDSEGSMSPSVDPSPAFNNFSFGSDSQGTNFMGQSQLANQPAPYPSQPQYNAYPNSSQPPINQYIDYQTTDSSGQAENQMMHAFSQAPQPQYAYQTDNSPASMPAAWQHYTSTMAGTFNSVPEIPPQPQLQMQPRPQLPTQRQNSIAAISPTNHGHAMVHNHMGDMGDMGMQHMGQGPPMNHSWPLNLFDMPPGGGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RQ63</accession>
    <name>A0A3D8RQ63_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_06845</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RQ63"/>
    <dbReference type="OrthoDB" id="4664297at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2970">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW76024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="170" mass="18578" checksum="AF5C8606AB3AAF73" modified="2019-01-16" version="1">MDSPTKRPEFNTKIPLRVTISTSTSSTDGPFDRPSIGLDISIQNTSPEPVLFLRWLSPLDPRAAAMGLFVFTSIKDGTQATAMNLKISRMLPEGGHYDTEDVVKIEGNGSINQKIAIKSPEVAFERGERYSVVAKGTWLHVKMGDHSALSTADDDVLKGDFESNIVEVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RV60</accession>
    <name>A0A3D8RV60_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_05811</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW77959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RV60"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW77959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="139" mass="14692" checksum="B7588D0AE0FF3C1B" modified="2019-01-16" version="1">MEPEYGVIWAGKEIELGSAKNVVSTAVKTSVDVGARHVALGLSDGFGLLHKITLHATRVSHGPVGWHLSSEDEFEWEGPQMDSMAVKRTGSDASTAITVGKNGCASNNDLGKIQILDTVIAHACIGIIENEVPRARTAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVT6</accession>
    <name>A0A3D8RVT6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrophobic surface binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_05912</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVT6"/>
    <dbReference type="OrthoDB" id="3485059at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021054">
        <property type="entry name" value="Cell_wall_mannoprotein_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123">
        <property type="entry name" value="CELL WALL SERINE-THREONINE-RICH GALACTOMANNOPROTEIN MP1 (AFU_ORTHOLOGUE AFUA_4G03240)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38123:SF1">
        <property type="entry name" value="HYDROPHOBIC SURFACE BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12296">
        <property type="entry name" value="HsbA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017693612" description="Hydrophobic surface binding protein" evidence="1">
        <location>
            <begin position="17"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW78060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="175" mass="17672" checksum="D41F7286652B9D4A" modified="2019-01-16" version="1">MVSFNTLLLIATASSALVIQKRDTATILSDIKTINTNLNALTSATTTYTGGLIQALPISNAEQTLDTSIQKAGTDAKAQTTPLTSAESLQVLAAANNLTTGINGTLVALSAKKAAFQSAGLTATVTGDIITLKTDTDVLSAALVAVASPDTKSQATALQSKINDQFAAASAAFAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWA8</accession>
    <name>A0A3D8RWA8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nucleotide-diphospho-sugar transferase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_06118</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWA8"/>
    <dbReference type="OrthoDB" id="38531at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057688">
        <property type="entry name" value="DUF7928"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408">
        <property type="entry name" value="CHROMOSOME 15, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35408:SF1">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25550">
        <property type="entry name" value="DUF7928"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="342"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="744"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="783"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="824"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="879"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="910"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7928" evidence="4">
        <location>
            <begin position="113"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="3">
        <location>
            <begin position="555"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW78266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="936" mass="105612" checksum="0870353B60C30740" modified="2019-01-16" version="1">MADLNFQLSNRKASESPTPTSPSSSSRSANNTSPSSPTALPSPVNGTSTTKIRFPQRPMGSLTPVTILSPFDSAETTPRTSIGTKNGRRSIYPKGDFRESVVSMQELRTMQNGMMAETLNKEQIRKLWTSTGTNEGVVLKVSKGYYIARPQSLQHETNGFFHQILTMNIRCAMTVNTKLVRVLMTEVEGPHVSLLNGNNIQILPTLDALPHCSRHQFAAFIRDTKILIVWDDNPENLLPRASELETMLLNTIWNDHDAFCADEKTNAAPFESVIALGPQANGFDSSDDLEALLPEERKIILLSPMIVALTLTLIITCLGFGWRALAVETAVDGTYTRLALLITSPFLFFMGLFMMQTIFGCMFQMFAPVKQMMENSMGYSGKAPRRRHGEILPHFTIQMPVYKEGLNAVIRPTIQSLKQAISTYELQGGTASIFVNDDGMQLLSQSEANERREFYDEHHIGWVARPGHNPRPKKDDPNFDESKMFVRRGKFKKASNMNYALMVSNRIEEKLAIISRDENWNQRDEEKVYKHAMKQVLSDLNGRAWADGNIRIGDYILIIDSDTRVPADCLLDAAVEMDNSPQIAIMQYSSGVMKVTDSYFENGIKFFTDLIYTAIRFAVASGDVCPFVGHNAILRWSALQEVNFEEDGYEKFWSEAHVSEDFDMALRLQAIGYKIRLAAYQGEGFKEGVSLTVYDELARWEKYAFGCSELIFHPFRLWLTRGPITPLFKRFVYSSMPIGAKLTIMAYIGTYYAIGAAWFLTLGNYFLAGWYSGYTDKYYLGSFQIYVAIIVVFTGLGNVALAVLRYRTSEKGLLASLFENFKWVLLLTIFLGGISLHVSQALLSHLFEIDMSWGATAKEVDESTNFFTEIPKLTTKFKFTFVFCFAMIALVFAGVYAFPEFWQIRTFNAIFPLCSIVFSHFMLPIALNPALMMFTW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWP3</accession>
    <name>A0A3D8RWP3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_06073</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWP3"/>
    <dbReference type="OrthoDB" id="5416609at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="46"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW78221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="646" mass="72583" checksum="7D0AEA1B3E8BA0C4" modified="2019-01-16" version="1">MDESCDPFPYQALGPSEIRVLKPRAATSGTFSFDLVVKDLSTKPRYAALSYTWGPPGNTHNIILNGQLFPVRQNLHDALAQLAKSRLIDNYIWIDAICINQGEDEVALKERSSQIVLMKQVYEQAKKIVVWLGKPENKLNNHSAAKKLREFSDFHRRVILKWNPYRPWIKPTAPVSHETIVADLRAQVKDSVESGRKDVLDKVGSYSYNAWLGISELLKSPWWGRTWIFQEATVPESLTTIFISGIWVKKFKSKVAFIFGDLETEWNELGIVSVIILELLYCGNTDKAFVAGLGRDSLPYNGLAEFRSQRILDTRHDFLELIYLFRHTDCFDPRDKVYAPLGLATDVVRKAIIPDYASKTTLQVYLEVPQFYLAQPTPTLDFLGHTIYIEQPTSDNPFPSWLPNWSDKAEHLKPIPKSIFRALPLPGKIYAPIDRRVGVPDTEMVPAFNASDTPAYTAFILENELHVSAIFVDIIKHNFPTDPFKVESLHEVLRQWDAEPNSLYATGETFVDALCSTLVMDLEFDFRERACARGGKLDSRSIADTDNLDSTLIDKTRHVAMGMAAGGRTVAITEGGYVGMVPSTARSGDSIWALLGGSVLYTLRKEHACQEGYTFIGEVYLHGLMDGEVMKRVAAGTGEIESLVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RX43</accession>
    <name>A0A3D8RX43_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_06256</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the AB hydrolase superfamily. Epoxide hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RX43"/>
    <dbReference type="OrthoDB" id="284184at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000639">
        <property type="entry name" value="Epox_hydrolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43329">
        <property type="entry name" value="EPOXIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00412">
        <property type="entry name" value="EPOXHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="31"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW78404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="351" mass="39202" checksum="6F97743E29B860B1" modified="2019-01-16" version="1">MPSFLPNKSLTLPSGTTYSYVYHPASDPNKPTLLFCHGFPSTTHDWRFQLAYFSSLGYGVLAPDMLGYGKTSKPTDLSAYIGQKMAADIVGILDHEKIVGELVGIAHDWGVYALSSLVIYHGDRFTKLVFVSVAFMPPKVGKDGQTMDYETLLQVNAATEKMLGYPCFGYWFFFNEPDAGKTIGEHWESFYELLYAEDTDLWQKHLAPVGAAKTFITTDQHAKSASYFTPEDKAYFHSVFGADYSAPTCWYKRSLAGLGVEEERKAIEAGEVKTWKVDSKLDKETLLVTGTRDAVCIPEIGRQSMRKFTEEGKLRIVDLEAGHWVQLEKATEFNQALLNFIQGAGDGETKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2Q1</accession>
    <name>A0A3D8S2Q1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Choline transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_05281</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2Q1"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649">
        <property type="entry name" value="AMINO-ACID PERMEASE BAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45649:SF27">
        <property type="entry name" value="CHOLINE TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="281"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="337"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="414"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="496"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW80583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="551" mass="59625" checksum="1FDBD621784E328A" modified="2019-01-16" version="1">MAEQVLPPYPLPPNAEKGKTAPDGPTTPPIVEVNETGHVQELERLHSLLSICSVGIVTGNTWAALGGSIAVAIYNGGPPGVIYEFIVVSIFYWLIAASIAELASSMPSSSGVYHWASITPGPKYGRIIGFLAGWTNTFAWMCASASMASITGNICVAMYGVMHPDYVQQRWHVFIAYLISTWLAASIVLFGNRWIPLLNNIGLFFILGGVFITILVCAIMPHTKSSGYATSSFVWSDWSNQTGYSSNGFVFLAGMLNGAYAVGTPDCVSHLSEEVPNPKRFIPLAIAAQMAIGFFTALFYMIAIFYATTNLDDVLGAPYFPLSQIYFQATSTKAGTVGLLFVILVPIFCTLIGTFITCGRTLWTLARDGAVPFSSTLKIVPQRFKMPFNATVVCAIFSTILGCIYVGSIAAFNAFVGSFVILSTLSYLAAIMPFIFTKRFSNVALPPGPYINSMKPGPFCMSSAVGYTVNIISCLYIIVFIVIYCFPYSMPVSAATMNYSCLITGAIVMFAGVWWFVGSRDYVGPQAMNEEYAHERTMSTPTGQQTGEKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S346</accession>
    <name>A0A3D8S346_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_05219</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NMD3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S346"/>
    <dbReference type="OrthoDB" id="203821at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048899">
        <property type="entry name" value="NMD_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21193">
        <property type="entry name" value="NMD_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21192">
        <property type="entry name" value="OB_NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="12" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="9">
        <location>
            <begin position="30"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 SH3" evidence="11">
        <location>
            <begin position="263"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 OB-fold" evidence="10">
        <location>
            <begin position="327"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="480"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW80521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="521" mass="59033" checksum="3409EF3217833718" modified="2019-01-16" version="1">MSSAMDVDAPVSIAPRFNNQEQQTGATILCCNCGAPIDGTTSAGALCYDCVKLTIDVSGGIQREATIHFCRDCDRWLLPPSTWIVAAPESRELLALCLKKLRGLHKVRIIDASFIWTEPHSRRVKVKLTIQDSVSEGVVLQQSFEVEYVVAYQQCPDCQKSYTANTWRACVQVRQKVPHKRTFLYLEQLILKHGAHKDTINIKEVKDGLDFFYAARNQAEKFVDFLSSVAPVRSKKSQELISMDIHTSTKSYKFSFSVELVPICKDDLVALPIKLAKQVGNISPLGLCYRVGTSLNILDPSTLQTADISTPIYWRSPFTPLADVQELVEFIIMDIEPLGPVKGRWALAEATVARASDLGSNDRTYYTRTHLGNVLHPGDSVMGYMLTGTNFNSPQFEALEEHNSYSAQIPDVMLVKKFYARKKKGKNRNWRLKRMTREEGDMLPRKQDQEKMDRDYEMFLRDVEEDTELRQTMALYKAQQAQREADAMSMAETSDGEDETPQINMAELLDEFEELQMEDHA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S353</accession>
    <name>A0A3D8S353_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_05202</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S353"/>
    <dbReference type="OrthoDB" id="3495013at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW80504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="141" mass="15974" checksum="DCFF7B9CE0B66632" modified="2019-01-16" version="1">MARKHQRYQTQPMATLWSRKTLLILWFTQISVSLFCSVFTAICYPLKANEDRADDGLSFAFYVVLAFQVFAYTILSLGLTLLQMAQYWRGDLSPKWLLVPAWCTSVIWLATGIQGVSYAATSTLGPFTVFEVVMVLDVLVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S398</accession>
    <name>A0A3D8S398_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_05269</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AFG1 ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S398"/>
    <dbReference type="OrthoDB" id="548867at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001493">
        <property type="entry name" value="Mitochondrial ATPase (Afg1), putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005654">
        <property type="entry name" value="ATPase_AFG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF040713">
        <property type="entry name" value="ZapE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169:SF6">
        <property type="entry name" value="AFG1-LIKE ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12169">
        <property type="entry name" value="ATPASE N2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03969">
        <property type="entry name" value="AFG1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="528"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW80571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="555" mass="62635" checksum="786C1FE392164F88" modified="2019-01-16" version="1">MKPQTSQYRALQRALRQSNSIPSARRTICSSGSRIPAAAIKEGPASGTVLRLRYSTSATSRKHLLVRPATFVAGQRRSLATVKQGNPDDQGPMQEYDARVASGRLRDDEHQRGIIQSLQHLHDELRDYKAPPIVHPKLESLQPEPQGVFGRLFRSKAPKEKPLQAIPENLPRGLYLYGDVGSGKTMLMDLFYDTLPAGVASKTRIHFHNFMQDVHKRLHAMKMQHGNDTDAIPFIAADIAERGNVLCFDEFQCTDVADAMILRRLLEALMSHGVVLVTTSNRHPDELYKNGIQRESFIPCINLLKNRLHVINLDSPTDYRKIPRPPSGVYHSPLDNHAADHAEKWFRFLGDPTQDKPRPETQRVWGREIHVPKVSGRAAMFTFDELIGRPTSAADYIELTRSYDSFIVTGVPAMTHRERDLARRFITFIDAVYESRAKLVLTTAVPLTQLFLSKDEIKDSLKQDGKAGAEKGEVQLNDAMRMMMDDLGMNIDQLKSSSIFTGDEERFAFARALSRLSEMGSQEWVERGMGLEKHGGKADKDNWQKVRSKQLEDSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3A2</accession>
    <name>A0A3D8S3A2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">p-loop containing nucleoside triphosphate hydrolase-12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BP5796_05485</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000055">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000066">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001854">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF399">
        <property type="entry name" value="ABC TRANSPORTER ATNG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="156"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="336"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="769"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="819"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="918"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1002"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1035"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="125"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="498"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="14">
        <location>
            <begin position="779"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="13">
        <location>
            <begin position="1096"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="461"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="420"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDW80787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1337" mass="147533" checksum="4940769625F3A175" modified="2019-01-16" version="1">MPDNTAIACIFTAIVGLKFILLILEAKEKSSLLRSEFRRPSPEQTAGILNRSFFWWFNPLLLTGFKKSLVIDDLFLNDDTLAFNTWRDQVHHRWANTDVTKPHALLKVMLGTFKGLFLAGVIPRLCLTGVNYAQPFLVSRVVDFMDQPETESSNKIAYGLIVAYAFVYIGIAIMSTMSQHKTYRTIVAVRGSAVSLIYRHTLSLHSSSTSTSSSLTLINNDVERIGAGMKDLHEIWASLIEFALSLWLLEMRLGVSAVAAILLVIACILGFAKLGMLLGSRQKAWLEAIEARITTTVATLGSIKGIKSTGSTDIVERIIMQMRLEEIKISRKFREVLIALVTLSYISTTFAPVFAFATYSIISNIRGSTPLLATSAYASLTVLSLLSQAVSKWIDASVGIINSITSLERVRQYLASTPRNDPRTVDSNKEDTGKLHPDEELITAIPGTELFDMGSVDHSRDISLPNAEDSPAELPDLRPTQQRRSSHRLSLEQKIVTIRDCSASWTKNSDPTISNINMKILRGSLVMVIGPIGCGKTTLLKVILGEVPHTKGTVVVGSAEAAFCGQSPWLTNASIRDNIIGGSYLDAKWYNTVVKACALDQDFTQISDRDNTVIGSKGISLSGGQKSRLALARALYARKSLVVLDDVFTGLDTKTERHVFNSVLGSYGLLRQGGITTVLATNSVRNISLANHIIILGPDGKIIDQGTYHDLVHASSYLESLNTRQSTLNESEPERTADDTVPELVVAGTASRAIGIDDRRKSDLATYRFYINSVGWVTWWVFVLLCSGFVFGLVFPQIWIQFWTEANAKKANYRLEYYLLLYALWSVMAIVMFLGACWWLMIRMMPRTAIKFHGVLLSTVLRAPLAYFSATDGGDVSNRFSQDLELVDMGFPTSLIGTTVAFLSCIAQVGVVIYGSSYIAAAVPGMVVLLYYIQLFYLRTSRQLRLLDLEAKAPLLSHFMETIHGLVTVRAFGWTEKFTYQNSGLLERSQRPVYQFYCAQRWLNLTLEMTVAFLAIILVSIAVTTKSSSGAKIGLALVSIVGFGVSLKGLVYNWTALEIAMAAISRIRQFAIDTSSEDQPGENRTLPPDWPHQGMVTFQNVSSAYSPTSHLVLNGLSFSVKPGAKLAICGRTGSGKSSTIATLLRLIDLRCGSIIVDGVDISTVVRQELRSKLITLPQEPFYYHATIRENLDIRKEFSDKELLEVLDAVEMREVIDKKGGLDAMANEDLLSHGQSQLLCLARAILRPNKILILDEATSSVDKETEAKMVAILKERFQDRTVICVAHNLNTIMDYDEVIVLEEGRIVEQGKPSKLALEPSIFASLLHAVDGESDSASK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3C1</accession>
    <name>A0A3D8S3C1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_05505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3C1"/>
    <dbReference type="OrthoDB" id="5396at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004061">
        <property type="term" value="F:arylformamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019441">
        <property type="term" value="P:L-tryptophan catabolic process to kynurenine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.50">
        <property type="entry name" value="Putative cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037175">
        <property type="entry name" value="KFase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34861:SF11">
        <property type="entry name" value="CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW80807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="306" mass="33323" checksum="3A86ABE65F2410D3" modified="2019-01-16" version="1">MAGNNNKHLRTGRRPKFAELPLDPSYPAHAAWGIYGLDDELGTLNLLTPERTVAAAKEIQTGTRIGLNWGLEHMDYTGGFREILKHEILQIGQNCNDDRLEFNTQTSSQWDGLRHWGFDDGRFYNGLTQSEILDRENSTLGIHGMHLMEPGRHRGPRGALGLRSVCGADGHRVRPGALPRDPLGDDPADGGGESRRVSHGGYRASTHRQVIPFVRGLNTYSRRGRVHDGVPTDGPGSERRNHGRAPIPISGNGGLARSRRLALGHGDRSRGGRLSWLRELAADQACDASDPAGGIGPAYWGDVCSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3H3</accession>
    <name>A0A3D8S3H3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Folliculin-interacting protein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_05540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3H3"/>
    <dbReference type="OrthoDB" id="5428015at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042030">
        <property type="term" value="F:ATPase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028084">
        <property type="entry name" value="FNIP_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21634">
        <property type="entry name" value="RE13835P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21634:SF9">
        <property type="entry name" value="RE13835P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14636">
        <property type="entry name" value="FNIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Folliculin-interacting protein N-terminal" evidence="2">
        <location>
            <begin position="82"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="858"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1134"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="640"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="735"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1134"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1153"/>
            <end position="1162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW80842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1229" mass="134598" checksum="25645277FC0323A2" modified="2019-01-16" version="1">MSLLGKLFSGLPSNGGTSASRPVTAQHLESAVEDRFTYDLLFPSPEALLNTEFADPLSTSTLLPSTTNAFDYNGDVDVEIRDVRIIIMQEATLSSVNPYLLYDSHELAPPTPTLEHPQSTSGPTQSQPRADARRSAPSSRKTSLVQNSRPVVIQQEPIAPRAFGAFDRRPTHTKTLSYTETEAQRAAREYKEEINMFSNCIWGQSDILAYKGVGTKVHPLPSDTRHAATSSSYQNDANGSFGRSSMRGSRLAQSFTLDNANPGPTSAGFSTTSNARGSDRRKVLITRMFPVPLPNDDTEDSQTRTPTALSQSNDTAGYPFPRVSSDGLSPETKKPQPKQKRTPMYAVGMIIQLPSATQIASAPASRSSFRGAGSYTEQESFPSSFNSSRRSGWTMLGNGFGVESLESSFTSDVDDRFDVITPHWDIIMRTLSHLQAVTTAVLLPLLKQADINSPDPRRSSSASQHNRMPSVSVSISGKRVADDVKPFKIPKTNAKLVQLTQKCLSQNQKIQKEVDSSRQRVVNGIKARQVVTGQGRWGIWREQARECGKWAGGKEQGFFFFNLLTGFLGNHTEWLQVLGPTWYRRRHYQQQRANKDEDISLPARTIIVSDNKMEARRLVFLLAAFLPSNHQVPGARLHRPSTSASFGGYSQSPPTYTVPRLREESLRHKINRRPGGNARSTHSRKSSFATQVNQNNGLGLSSFPQTEIHHDRRVSDAGSIKTANLPIPGSDLTSRKSTTATASTAKPETTLTHFITTRRPGCGTGPMPRPGSSGSLATDDLLRSLKRGDSTYSNASTESQANSRWGSMISGFWGSRRRDSSANTDATMPSIEGLEINDPHYTGGAAHPRDKLAEMVGEAGRHQTSQAKRIAEREAGNSDSDQTVKLADGETESLSGLAVKGEVEDIAGPRNQVVERVPDPSGAFESPVKTSINDDGIIDIDIPMPDLLSFETAVSSPSSSGYLSTPGFGNGLEGFEHYSRAGPDADTNINVGGWLQRYHPDFALQAIPAYAELLEEVKASMRAEPTPILTSTPNPDGRPSRWVDISSAIIADTTNFTIKRIRYSRLVKLKDMEHTTANAADTMSRYGNVYSTAQLTPSFDIYDSHMEEKFVEEAIISMDETLIEAVERIIAQSGEGSKATSACSSRSTSVKAGVRERSDSGPELKPTTNHIARHPEVPRNKCRKMVLNALEEIVKEVAESRREGGETEEKESVLREGVRSWLVNVETME</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3R9</accession>
    <name>A0A3D8S3R9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_05604</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3R9"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF55">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="415"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="519"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="580"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="609"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="646"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="682"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="350"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW80906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="721" mass="81344" checksum="72470C84C1999CF0" modified="2019-01-16" version="1">MKTDFRLGAGRWLVSLLAISQATAFYIPGWSVKSYRDDEPIPLLVNKVYSDNTQLQYAYYDLPFVCPPTGTRHANTNFLSGQSISLNLGEVLRGDRIMTSDIELVMGQDQECNFLCSKTVNRRDLKRARQMVKDGYVAEWIVDNLPGATSFVTVDKTRKYYAAGFKMGYKDFSPTGKPRYYLNNHLTIVLRYRKAPGRDGEKGGKVIVGFEVYTKSVGHEKRLESGCPADIHNVETPMELYLRPNATDFSIQYPHSSYYPPESEQDLDDGATMDIPYTYSVYFREDESIEWNHRWDLYFVNQEEGSRIHWLAIVNSLIISGLLSAIVAMILARTIRGDIKTYKDASAEEGKLKQKRKSRPSSGARTPRSGEKTGFGLLEQVGDTENDADISSDDEPLEDVTGWKLLHGDVFRAPAYGYILAPLIGSGMQLVFMAIGLLFLSSLGILNPSFRGGFVSVGVGLFIFAGVFSGYFSGRVYKTFGGLNWRKNTFITALLFPGLLFTLVFILNLFVWAQASSTALPFGTLLGIVMLWLCIQLPLVYAGSWYGYVKTGAWEHPTKTTTISRQIPVQAWYNRSPQSILLAGLIPFAVIFIELLFVFQSLWQDKSGYYYVFGFLSVVSIILILTIAEVTIVTIYIKLCSEDYNWWWHSFFVGGGSAIWVFLYCIWYFFTKLHIEGFVSSLLFFSYSFMACVVYGLLTGTVGFLTAYAFIRRIYGAIKAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3Z8</accession>
    <name>A0A3D8S3Z8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chaperone J-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_05519</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3Z8"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052594">
        <property type="entry name" value="J_domain-containing_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44144:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="29"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW80821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="290" mass="32600" checksum="88998A754012982C" modified="2019-01-16" version="1">MSDEHQTQEQRAVSEVKNDIIQDVLHEEDLYKILGASRNASAADLRRCYLERSKVVHPDKPPFHAQSTSAFQRLGFAFDILKSPSARRTYDRASKPTSSQLPDKTTFLGGEHTFRSAVESILQEFMTGDFVIVRRWLESLHSRYPNLVSEEVVVNVERSFIRIRELVLTTRTYALLIYIELGRIHRVQKRLMGLGYLDVVGRARLTVHLVRVTLAVPMRVDRALKEREEKAWRAKVAGLQAAGVAPTGSMRNAGILNERVSKVLEFIVGAAGKDEGADEAWSTKMAGAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SA33</accession>
    <name>A0A3D8SA33_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_04697</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SA33"/>
    <dbReference type="OrthoDB" id="2951834at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW83206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="269" mass="30499" checksum="E8C2A8C9A4CFDF11" modified="2019-01-16" version="1">MDLHHMAARDMEQRLQSHDFTNPDFAQLARVLQRCHEDVQKQNSEAERINQALDRMDWKLCQQLDQSREHHHVVPRQVPTMVKTPGLFSFMELPPELRLKICHYLLVSPGPISVPDTAPPSGPYPSVAILQTCKLINQEATPLLYGSNAFTISITSTPSDTPLAMLSKLRWQTISLLPEINFISSNPSSEKAKPAPFTCTGHAILAQFKPSDFRLSPVGMDQYHVRHASNWISCQVMRAELVAFQNEWKGLMEPSNWELPAIDWESHGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAJ2</accession>
    <name>A0A3D8SAJ2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04878</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAJ2"/>
    <dbReference type="OrthoDB" id="3943049at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW83387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="216" mass="23710" checksum="6126CBD8A6C5C026" modified="2019-01-16" version="1">MVRNCVGDQTFGKNAVQEEELSQGRRKLKRFNRPSSNSWSLISLKAVAEPLVSAAKELSSSCPLLLPSNTTRLCAGCVFFSFLSSTFLSSCDWFPLSLSSSLSDFLLCKILCLPLPNPSLDRSIDIVSGQKPRTNTHITPKRISPDTAIMGSAFSGPDAFKFFGFTPKATAVLQKNPELLAILVACLVGCILLGLLAYYIHYETNKPYRKPKPTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAS2</accession>
    <name>A0A3D8SAS2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome biogenesis protein RLP24</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_04887</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAS2"/>
    <dbReference type="OrthoDB" id="10262490at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902626">
        <property type="term" value="P:assembly of large subunit precursor of preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000001">
        <property type="entry name" value="probable ribosome biogenesis protein RLP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF8">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN RLP24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="TRASH" evidence="4">
        <location>
            <begin position="6"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW83396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="186" mass="21890" checksum="91ACE1F61FB653F8" modified="2019-01-16" version="1">MRIETCYFCSQPCYPSKGITFVRNDARQFRFCRSKCHKNFKMKRNPRKLKWTKAFRKSAGKEMVVDSTLTFAARRNVPVRYNRELVATTLKAMQRVGEIRQRRERVFYKKRMEGNKERERAANRKLVAENDHLLPKVRGSERKALEEAGHEVEEVIERPAAKVFGKMKIRQKALVGGGMEDEMEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAS5</accession>
    <name>A0A3D8SAS5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Fungal trichothecene efflux pump</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_04926</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAS5"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06179">
        <property type="entry name" value="MFS_TRI12_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053791">
        <property type="entry name" value="MFS_Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF109">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="460"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="552"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="67"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW83435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="603" mass="64045" checksum="DB896C33C876E79D" modified="2019-01-16" version="1">MSTEKADEMATTTEHVNDIDRVTTMQKNAVQQTHTDGTVDYVDAKAFGGDLEAMPPGYFYSVQFIGTVVAVCCASICAYLGWVLPANTLLLINEDIGPSPNLNWVATVWTLGTAVGFLLVGRLSDIFGRKWMVMGTSVLGLVGNIIGCTAQSINTLIAANACNGVAAAGQLSFGIVLGELVPNKQRGPIVTLVFLSSLPFAVFGPIIARSFILYTSAGWRWSYYLGIILSVVALLLYQFLYHPPTYKQLHVEGKSKWQQVKELDFVGMFLFISGTVLFLIGLSWGGGVYPWKSAAVICTIVIGALLIVVLGIYESWISSRGHSALIPPRLFKNVGYVAVVACATIGAMVYYSMTILWPTIIGTVYTTDVKAIGWQSSVVGGGILLGQVCGGFALSYIPKVKWQTVIMACLALAFSASLTTVAPGNHSTFIALGVLACWAIGYIDNITFPGVTLVIEPQDIGLATGVLGSIRALGGAVAQALYVSILTNKVSHYLPEYVTPAALNAGLPASSLTSLYAGLTAGSFAKVPGITPAILAQVGAAVTHAYVSSFRIVFFATIPFSVLLIVAAFFVPNMEKFLGNNVAKRLQGKVGGNEQVAEKNETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAX7</accession>
    <name>A0A3D8SAX7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aldehyde dehydrogenase (NAD(+))</fullName>
            <ecNumber evidence="3">1.2.1.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_05020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an aldehyde + NAD(+) + H2O = a carboxylate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:16185"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAX7"/>
    <dbReference type="OrthoDB" id="310895at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004029">
        <property type="term" value="F:aldehyde dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.309.10:FF:000012">
        <property type="entry name" value="Betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.605.10:FF:000007">
        <property type="entry name" value="NAD/NADP-dependent betaine aldehyde dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11699">
        <property type="entry name" value="ALDEHYDE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="5">
        <location>
            <begin position="3"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW83529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="456" mass="48920" checksum="9611147C467940D0" modified="2019-01-16" version="1">MVVAEASVDDVDSAVAAAETAFPAWSALSPIERGKPLKKLAEMVLARKDELANLEALSMGKPVGDYFDAGYAGVQFNYFGEAAYAQGNTSLNTPGFLNMSLRQPFGVVAIIIPWNAPLVFFSKKVGPAVAAGNTVVLKSSEKAPLTSWKVSQWITECGFPPGVINILSGHGHISGSAMSSHMRIRALSFTGSTRTGRAIQIASAQSNLKKVVFELGGKGPALIFEDADLEEAAKGTEHSINGQSGQTCMANSRVYVQESVKERFLEAFKKMASSRRIGDPTDPSVNHGPQADKVQYDTVLRYIALGKETGNLILGGGLDEPARNNYTGAKGNLTIHPVIFTDQPEDSRVVKEEIFGPVVVINVFKTEEEVIAKANDTEFGLYASVWTKNLERALRVSKKLESGMVGVNCASPTGSWDLPFGGYKGSGTGRESLLESMEHYLEHKSIYFKVSGIGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SB55</accession>
    <name>A0A3D8SB55_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Steroid 5-alpha reductase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_04872</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SB55"/>
    <dbReference type="OrthoDB" id="201504at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010721">
        <property type="entry name" value="UstE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32251:SF23">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE (DUF1295)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06966">
        <property type="entry name" value="DUF1295"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017826840" description="Steroid 5-alpha reductase C-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW83381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="19518" checksum="5E5B9FCB85368D00" modified="2019-01-16" version="1">MVTADTVFVRGLMGLVLVEFFADQQQWDYQTAKHSYLKTAKVPPKFNQIDLDRGFVTSGLWAYSRHPNFAAEQAIWVVLYQWGCWSTNVVYNWTSLGAVSYLILFQASTWFTELITSRKYPEYKEYQQRVGKFLPKLTGGLPGDFSDKKAKPKVETEKSPNAQTRKVSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SI69</accession>
    <name>A0A3D8SI69_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_04196</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SI69"/>
    <dbReference type="OrthoDB" id="4074350at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071944">
        <property type="term" value="C:cell periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051694">
        <property type="entry name" value="Immunoregulatory_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549:SF26">
        <property type="entry name" value="AXIAL BUDDING PATTERN PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15549">
        <property type="entry name" value="PAIRED IMMUNOGLOBULIN-LIKE TYPE 2 RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017648182" description="Peptidase A1 domain-containing protein" evidence="8">
        <location>
            <begin position="24"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="443"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="9">
        <location>
            <begin position="49"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="543"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="621"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="647"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW85871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="659" mass="70640" checksum="02137BB7F41BABB6" modified="2019-01-16" version="1">MRSLLKFGFFLCIEFGLSAGLEAADNITLAAPIIAVPSQHWEGNDGTWSTFEIRVGTPATTVRVLPATSWQEVWVIWGGVPGVCNTTEGVSTDCGDERGGLWEATSSSTWQQGDQLFLGLNQDLGYSGQGQYGFDTVGLGYSSDEGPTLTHQIVAEISSNSYFFGQLGIGFQPTNFSGYDDPQASFSDTLYSNGTISSMSWSYTAGAYYRLKGVFGQLIFGGYDASRFTPNDVVFTMTGDNLRDVVVTVRSIISTAQSGNVTLMSTPEFAFIDSTVPEMWLPADVCDAFESAFGLEYDTTWGLYLLDASTHENLLSLNPTITITLANQKSGGSTTDIVFPYTSFDLNVSAPIYNGTSKYFPLKRATDENQYTLGRVFLQEAYVTTHYNSRTFNVSQCIFSDSASERIVALPATLPTAASTATSSSSSNPRPAGTSNHKLSAGAMAGIVIGAVLGVLAIIGVIALFCLRRRRRSSQAAKENSRPRTPVAEIDAGKRVEPYGSSAYTAQASAFTHEAGGRAVAPRVEIGGYPIMHPQELEANVPIQWTRPTSAPHRSTDRGDMGGSTPASVSPTAGPGSQAHELSGGGIKNLERGNDFDDMVSPASPTMPGIMQRRRGDLDTGQDSSVVGDSPTISSEGHASPQTPSRSRRESRFEEHWGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SNP4</accession>
    <name>A0A3D8SNP4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_03639</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SNP4"/>
    <dbReference type="OrthoDB" id="2154091at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF83">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="17"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="85"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="89"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW87945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="681" mass="77030" checksum="EDBDC0274A8BB582" modified="2019-01-16" version="1">MPVQDQNARVRRRIGLACNGCRIKRTKCDGHHLQCSACKYREEQCEYTEAESKRKLRRPSKEYIAALEARVACLEERLATFTSDTRVPSTRSDSISESESLSRKSSNVDASNKSAQAIDKASVLMPIDELADVFGSFTIGDAGELRFYGASSNLNLNRNQDFRVTSSVGARMQGIKAAQALPGLQHHKGLWEISDDLRDHLLEIYWQWQNSWQYLVPRESFIKDLYTEKTSRFCTPLLLTAILAHASRYSDRIETRIDPHDPNTAGGMLYTQAKTMLHYEMEAPTTSTVQAAGLLALYGAAIDSEALGWVYAGMASRMAFSLGLHSDFTEYVPQGVVSAEDADARNVAWWGVLFGLGYGRPACIQEYNVTAAKPLTSVDNEPLTLAPEIQDSHSPAISISHMSVNAIYTCELFQITSEVLDQLYARQSGWTTTERDDYIMETHLKLVAFHDRLPKILKISPSCLQPAMPHVYQLHLQYHVQMILLHRPFFRGIATENSNEETSGDDDVHTRSCRLSAEKISNIFRNYSLNYGLRRIPISAVHPAYTAAVIHMADIKNAKDITRSKTMKQLQVLVKSLYDMNIAWSWSNRSIRAMETLAKEWNIDLWTGNLKKEVSQESFDSFQRYMAGDVYKRQDNLAIPPPPSVWPDIVNDNFLNLNWQFDPNFELGTDITDPKPVAWQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SPP2</accession>
    <name>A0A3D8SPP2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_03462</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SPP2"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="63"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW87768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="295" mass="32744" checksum="D1BF815975072D49" modified="2019-01-16" version="1">MESLNYVRLKVIASTLRLAQPCPVKSPNFDDVIQVPSRDADRTIKVHVYRPSNPEANAPSPVLVNFHGSGFVLYWHGSDDYFCRLVARKAQYTVLDVQYRLAPEHPFPAAPHDAEDVVKYVLSQPQQYDTTHLSVSGFSAGANLALVVSSLADFPKKTFRSVLAIYPPTDQATDPFTKKAPDPSGTPIPGNIASLFNQCYFGDQDPKNPMISPIFADANAFPENMLIITCACDTLAPEAEAFADKIEKEGGKGRHLVRRRVPGVNHGWDKLPDIDSEGEKKRDEIYDMAIEMLKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SPS9</accession>
    <name>A0A3D8SPS9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03502</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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            <end position="35"/>
        </location>
    </feature>
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        <location>
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            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="239"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW87808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="360" mass="39111" checksum="222857F7CA7BF7CA" modified="2019-01-16" version="1">MAETTLPRRSKKHNLQPLETNYEDIDGPNPGVHTATMLPLQSSALPSPSVLVAREYYRDHAEPGIYGDISPEAGALAIDAPRRHSAATVTKQLSDFSISSPASKLPQICEDSAAQSKDETPSANATKQSDLMKVSKIATRTAPSDGTPTTTEVLGPIPFQYTHDRLRTWGHTYLGNTATADAFINVVHLRRPSLALLKEGNNVVSSNTTIRARVIPKDRERKPFLIQKQFDVEELRSNIPPMQHEVLPPQSNRTRQSLSGPSQKLPSGLDGDPRCASPGGRASPAISGAFPIHIEYALHYLPALAALMLSGHVRKGDSIDIPIPHAGAWKEVMLYIYTGEGPITSAVRENVLYLGGRVDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXL0</accession>
    <name>A0A3D8SXL0_9HELO</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
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        <name evidence="2" type="ORF">BP5796_02227</name>
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    <organism evidence="2 3">
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        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <end position="98"/>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="95"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="148" mass="16451" checksum="B37EC6C39D3F6CE3" modified="2019-01-16" version="1">MPGASAKGIEWVSSFDERASPGLTQRTKEMLTSSLLRTQLHTLSSPSLAETPSTSPAKTPDMWEKHNILKAPMVESYHVSAQDSEADNNYNSSDSGCRRTLAHERLSYSMHQRIHVDNMANTRSQAPNKPVFHMPKAIQRGSALRQCT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXS1</accession>
    <name>A0A3D8SXS1_9HELO</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">BP5796_02224</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
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            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
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            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW91059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="115" mass="12826" checksum="441450636F122CCF" modified="2019-01-16" version="1">MIPWEPAPIGAPMLTLNMGESRSYHTRAIQNPHPRKVVWTSAGNLPVRPFESLLGRKLPYSVTHDTRTKVLPSLQQQRSLAYVCGIKPAPKVGRGDDADGVIRDVAGPWSERPWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXU8</accession>
    <name>A0A3D8SXU8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar segregation protein 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_02322</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SXU8"/>
    <dbReference type="OrthoDB" id="1204at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070772">
        <property type="term" value="C:PAS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010513">
        <property type="term" value="P:positive regulation of phosphatidylinositol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903778">
        <property type="term" value="P:protein localization to vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000011">
        <property type="term" value="P:vacuole inheritance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024260">
        <property type="entry name" value="Vac7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28258">
        <property type="entry name" value="VACUOLAR SEGREGATION PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28258:SF1">
        <property type="entry name" value="VACUOLAR SEGREGATION PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12751">
        <property type="entry name" value="Vac7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="707"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="562"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="802"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="34"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="629"/>
            <end position="655"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW91157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="927" mass="99209" checksum="C8A0D2C5E880F17C" modified="2019-01-16" version="1">MDDTSLASSGATKLPSKKSADSVASTSEDPASMKPASSSTPSLPATKKTQTQQKRGPSASNSPLPSREPSPVRPSLKGSVSARSSNPSRSRKNSHDTSPSRSSSTTNPPSLAATQRALSAASIPNLHPITSDPAIKAPIPLKPTVNSDFKDAPRWPVSPRLRSPPPTNKSSVLSPRKTEQDLPVVNVQRSLQNSPEQIDTKVIDIEVDDSLGTGMKTPARGVSGGSSTLETVQEISQPGTPALSLDGAVAKREDGSTKPSNDQDNMMEQAFGKAFKTKSNGANESGSDSGGKSDIKMRVASAAPATTTRAAPPTKSFSSSSTTAAPSRSKPAGDGSQMMTVETETVSSIPAVALGTGVGGVGMNGSLRAKPSSETIRPKREKKKAPRKAPSVTSGTGEHLHLTRPKKHHHHAARSPSKSDSDDAFATIRFPTNCKGQGPCKLDDLSEVTRPTRQVSFRRLSITNSGGNAILTRTRLASSKADIFEAKVASAVDEANSSDSEETFVYESNPPDTNDRPRRFHSRTPSATSMASQVDQRNGLRSMLDGGHSVAMKKSMKFANSYNSNGQDVATGEDDGRGTGRSNMGTGRGTAHHHHIGRWGRNGGNGHASLFDNESPFPNAAKSKLGSPRNGSRPTSPKVANNAKVMSQKKQSPISSGYDLEADDERTPLIQTIRSGRSGRTRRPVSSSMRQLEHQAARQHRSFLTRFAGCLVLTLMIVLVISGAVGFMFATTQPLTDVKVLTLKNVLASEQELIFDMQVVAHNPNLVVVTVDSMDMLVFAKSKHAGTDAEWREYPMAELRRRRGIQRRDDSPADPPLDDDPNTNPNLEIGHIYEFESPLTFDGSAFHHTTSTSLGELRVYKPGNRTVPGGSKRWGKVVQHEFDLIIRGSLKYTLPLSQRVRSVTVEGRVTVKPNAADQDPDSVHIIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZ50</accession>
    <name>A0A3D8SZ50_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">LamB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_02750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZ50"/>
    <dbReference type="OrthoDB" id="5295431at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11665">
        <property type="entry name" value="LamB_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005501">
        <property type="entry name" value="LamB/YcsF/PxpA-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003814">
        <property type="entry name" value="PRK05406.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003816">
        <property type="entry name" value="PRK05406.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292:SF0">
        <property type="entry name" value="5-OXOPROLINASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30292">
        <property type="entry name" value="UNCHARACTERIZED PROTEIN YBGL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03746">
        <property type="entry name" value="LamB_YcsF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW91585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="258" mass="28369" checksum="3072FFE0CF035CD1" modified="2019-01-16" version="1">MEDIVKKVEINCDMGEGFGKWKMGPDEELMKMIDVANIACGFHAGDPSLMLKTVKLAKAHGVKAGAHPGLQDLFGFGRRQMVIDPADMYAMILYQVGALKAFLDAEGVPLNHIKPHGELFHYMQRDLTICRAVLEACALFKVPVYGAKGADEEKAICEELGLPFIEEAYVDVAYDKNAKLIPIGQFKMVTPEEINTKVLSIGRTDASVDVEGNKLPLNFGDKPFSICLHSDMPTALENMKAARKAVDVLNAEKFPNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZB1</accession>
    <name>A0A3D8SZB1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7704 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_02817</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZB1"/>
    <dbReference type="OrthoDB" id="3587182at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056121">
        <property type="entry name" value="DUF7704"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37019:SF1">
        <property type="entry name" value="EXPERA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24803">
        <property type="entry name" value="DUF7704"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017830041" description="DUF7704 domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7704" evidence="3">
        <location>
            <begin position="3"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW91652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="152" mass="17118" checksum="D02F419E6DC0D92A" modified="2019-01-16" version="1">MSSNIPAFYRFILLWVEPISSALGAYLTLAAPDTYLNSYIPRTMTVRNPMQDMIFNQLGAAFFYVATSQGILLRYTYDIGVWKIVNGCLLGWDFILLYSWWSGMQMQGRLDPATWRSEDMSALVPILFITAVRAAIVAGVGMRASKSNAKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZM9</accession>
    <name>A0A3D8SZM9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hyaluronan/mRNA-binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02383</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZM9"/>
    <dbReference type="OrthoDB" id="2122308at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="144" mass="15852" checksum="8613F698E16F8448" modified="2019-01-16" version="1">MSQQPSVWCSVGKSHKFNDRDHAGLADGTAAPEEHLPRYFAKSGFEGNDPKKAKKNGAGKGGWGVDGDEVQDAGFNLNNARRRSNSSSYSAGLKDFKTKFEQIETEPVFEEELHGPELEDDLTTHRVNTESSEGSVDEEHKAKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T025</accession>
    <name>A0A3D8T025_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase SDR-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_01175</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T025"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009688">
        <property type="term" value="P:abscisic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321">
        <property type="entry name" value="DEHYDROGENASES, SHORT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24321:SF8">
        <property type="entry name" value="ESTRADIOL 17-BETA-DEHYDROGENASE 8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW91781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="275" mass="29102" checksum="6C00E7245788FA62" modified="2019-01-16" version="1">MSFHGVALVTGAGSGIGRDCAIAFAVEGASAVAFADINLDTAQKAADEAEAKAKANNPNLRTIAIQVDISNESSVELMVKRVQDEFGRIDYSVNSAGIGVQSPRPVTDTVMDEFQAFFDINVKGTMLCVRAVSQVMKLQEPQVIEGRNGPRNVGRGTIVNLGSANSFVAAPAIVQYTSAKHAIMGITKTAALDLAPYSIRVNAVCPSWVETPMVDRAFSSQQEMFTALVKSLPAGRIATQEEVSDVILFLSGPKSSYVTGVGWIVDGGTTLQMNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0A2</accession>
    <name>A0A3D8T0A2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_01389</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0A2"/>
    <dbReference type="OrthoDB" id="2406834at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF81">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="52"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="22"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="96"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="22"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="132"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW91995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="594" mass="66180" checksum="0F36268CC7E60DF8" modified="2019-01-16" version="1">MDPVSPVIPPAASPSVTNTILAASPDVNTVNNSPSTSEPPKKKQRRNKPTLSCEECVERKTKCDRGRPHCLACIKRQTECVYAQVANILEETTRSVANARRMTKPPKRKGPVTPGQTNGFEAPRQAPDPNTRSASRGSSSSSKGLLSNVPYSHPTASNVFGIGSEHPFANYWTCQGGLPETISVLPEKVQADILLERYFECVDPVYPMIHRQTFYADYEQFWSLPQPEKDRVDGAMVALIFAMLAMGTQFVTTTLPKERQQTAEFYVSASHQSLRMSSYLNKASIRSVQAMVLITYFLINDNHASDGWAFAGILIRQAYAMGLHRDPNIVSPNASIFEKQIRRKLWQAVLLQDTFLTVLLSLPPSATHTDVNVEDLIDDSSSIAHSSPMDTAYIRGCWTLANLVQETICSPRSLDLPICSTVRQKHKLVADFRAVYRSLPDIFRSWDAESISTLAQSNKRIVRQTLFLTSNFHHNMMLLHSSASPEVPVNVRGALEAAHDAIQAFFILYALFESEAKIWWVFNHRAFLEALCIGEMLCEQAKDEAGQEALGKDPIFTRAKADIVKMIDIMQKMSEGEHGSEVAKTRVAVLTNYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0L8</accession>
    <name>A0A3D8T0L8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_01365</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0L8"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW91971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="162" mass="17206" checksum="2FDC64D89CFE608B" modified="2019-01-16" version="1">MDEGPAQVEASELIAFSHSPLAAASAAVCLRLCSSVQCLEPADDHRKNCQMAHGCAEPHGWNLETEQDQQQGEANDLAGARSLRTLGFRGSQGGCDLLKTPPAVHNFDLPRKPIPIQAQPRKPPTTNGAVPARMSSQIANTEMELNILAPTNACEIVSAVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0S1</accession>
    <name>A0A3D8T0S1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_01557</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0S1"/>
    <dbReference type="OrthoDB" id="506498at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW92163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="186" mass="21246" checksum="2A87D5B7D1C55ED6" modified="2019-01-16" version="1">MTPDETPENLYLQADDLNRRMLASGIHVNRWPRYLRDMYHALRPGGWCQLVEMYFSVQSDNGTLTEDHALRQWTAAYMDSLRDVKDLRAPLRLREMLTAAGFVDIEHKVIPLPTCGWSTDPRQRDIGIVNRDNIQKLLSSAALYPFVERLGMPVQDAHLLIANARREADNPAFKASQTLPITQPCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1C6</accession>
    <name>A0A3D8T1C6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Aquaporin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_01615</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1C6"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015267">
        <property type="term" value="F:channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47002:SF2">
        <property type="entry name" value="AQUAPORIN AQPAE.A-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47002">
        <property type="entry name" value="AQUAPORIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="215"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW92221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="237" mass="25310" checksum="9A8E2E707B8F62FE" modified="2019-01-16" version="1">MPAAFVAVSNIFLLSLFIYGLAPASGGHINPMITFATIITGLTGFARGVLYLIAQTCGAALAGGLIRGSFGRNLTLLYGGGGCLFQPGLMTAGQVFLIESVLSFCQIFLSFGVGLDPRQHAVFGPKLGPLLVACSLALVSFSSVGLGEGYPGAGLNPARCFAFAVSRGDFKYQWIWWFGPVTGAVVHSLVYHLAPPYHRQLREEAVETKMAYQKHHQDANRESQHEANEKMADGNLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1F1</accession>
    <name>A0A3D8T1F1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA endonuclease activator Ctp1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_01796</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1F1"/>
    <dbReference type="OrthoDB" id="5801062at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013882">
        <property type="entry name" value="Ctp1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08573">
        <property type="entry name" value="SAE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA endonuclease activator Ctp1 C-terminal" evidence="6">
        <location>
            <begin position="801"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="152"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="298"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="395"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="531"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="676"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="203"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="300"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="325"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="415"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="456"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="533"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="676"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="716"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="746"/>
            <end position="755"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW92402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="948" mass="106939" checksum="AFAD6B3A39A7B51D" modified="2019-01-16" version="1">MDQWRNERASRKERFEDFFAEYEAELAVGMNRPAYMTSIALTSPGLKGKLLEADELQKLRKAATEVERLKEQNIQLGNSLREQQRLREEATQATKLAEDNARLQLENQSLKESRDRLSEDLRDRLTAAAEKVELEEEVHRLTEELKESRQKLQEVRQNIQGQQAREKLSTPDTDANTSPVTSASPNTEKPTSAREHDKLVARYNKLCKNHKETEEARKVLEDTLRRRKSERRDWDRLGKEQKLEIEQKADRISRLEEEIHRLRAQVEELEKNHGALRSASPLNVCEGNVADLPQPAVQYPSRSAHSRSPNTSGNDVATGEAVTMAERESIPKDRSRGQMTVESNPLDDATRSELSVSSAYPSIPVPRTTHPFQATRNTLLAENTDSDVASAPLVRLETKPYANSEDETQGSSPRRASDKEQSFHSEGERLAMKSSESPEVLEVRRVSKRKRKTDATEASSLTKIKTEPASSSPIGIVGMISYHDSMDLDEIGERIKTPTKKRHFDVLNQATDIWNDESRDEVEEACADRTANAPLTTPAQPKTSALQPLSPNRRILPSTSNGKTSRRRIASNKEIGSLAEDGGISQEVKSAKMLSPLRQSELAARLENLLEGTSPAKHVLTRPRAAASSEQKISPRKSTFLHSRDANMASENVTFPTQETPVPYSRLSRPSANWLTPGSDLSSPNEAAYISQSTPSGASKGRMRTRTLKAKPPIGPQNQPQLITTSPSSEDLQDAREKLSLTRNSVNRKAHRRSTVAKNQDSEMVDAENPDNEPLRSRPLHRLGLEHFKVNPAYNGGYDYAFTDVVRGKVDRACLQGCVKPDCCGSKFRTLAESLYREPLTAEEKEEESRLLDDFLGDNRSKLRNMTPEGRKDLVIQAKIRELSNQYGKHRQQFHRSSSIPGLWDTDFPNTQEDEELRQKQYQRERELVEQRHMEAMRPGGAYLFKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T299</accession>
    <name>A0A3D8T299_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_02058</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T299"/>
    <dbReference type="OrthoDB" id="3465210at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF15">
        <property type="entry name" value="NICOTINAMIDE RIBOSIDE TRANSPORTER 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="65"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="486"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW92664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="549" mass="60632" checksum="E9231D0D042CA711" modified="2019-01-16" version="1">MSKYFKWAELPPRTDVYTHAGTTTWGNHDLYPIPRKERTWGWLAYVSYQIVVGVTISGYTLASTYIAVGLTVGQTMAAVLTGSIVSAIISYITCRPGLDHAIGFTVWMRTIFGPRGVYLQIFFMCIAGIIFSGLQSYYGGLAFTVMLSAVIPQFAHMKNTLPASAAITTQELIGFLMFFVFYIPMILYVKPYQLRRFMYPVFAIITIIMFGLLIWAIHGNGGSAGSLISSNPTELSTANRAYRIVQCIFSIMGTYGGASERFSDWTRFAKTRQSPTVALLVIMPLTGIFSGMIGALVTSAYYESSGNLVWNPLTLLSDLQANNYSPAVRAGTFFAGGGFFICQLVVNMCNNTVGAGMDISGCLPRYLSIRRAGMFMVIGSIIVQPWRFLSQASVFTEILSIVSIFFSVSCSMLVVDYYFVRKRKLVIPDLYTGGPQSIYWFHNGVNWRAIFCLLWGMWPSLPGLVYTVSGKTLDASATVWTRMFQINYIIGAPLAFITYFAISYFIKPPGLGVQVSMDEQGDVIEGVLCEGSNNGDDKKVAKATEKSAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T737</accession>
    <name>A0A3D8T737_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_00128</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T737"/>
    <dbReference type="OrthoDB" id="10013825at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.10.10">
        <property type="entry name" value="Trypsin Inhibitor V, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021719">
        <property type="entry name" value="Prot_inh_I78"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39600">
        <property type="entry name" value="PEPTIDASE INHIBITOR I78 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39600:SF1">
        <property type="entry name" value="PEPTIDASE INHIBITOR I78 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11720">
        <property type="entry name" value="Inhibitor_I78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW94365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="65" mass="7144" checksum="66B6EADED0B37EC3" modified="2019-01-16" version="1">MPLVVPGINSQGGGNDKTSEWMNKLVGKKIGDTSDQVTFARAELPKETRVIEPGQMVTKDFKPDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T768</accession>
    <name>A0A3D8T768_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">3-oxoacyl-[acyl-carrier-protein] reductase</fullName>
            <ecNumber evidence="2">1.1.1.100</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_00158</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17397"/>
            <dbReference type="Rhea" id="RHEA-COMP:9916"/>
            <dbReference type="Rhea" id="RHEA-COMP:9945"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:78776"/>
            <dbReference type="ChEBI" id="CHEBI:78827"/>
            <dbReference type="EC" id="1.1.1.100"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.100" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T768"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004316">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009688">
        <property type="term" value="P:abscisic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050259">
        <property type="entry name" value="SDR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42879:SF2">
        <property type="entry name" value="3-OXOACYL-[ACYL-CARRIER-PROTEIN] REDUCTASE FABG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ketoreductase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW94395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="287" mass="29873" checksum="9B55385DB1B46FE4" modified="2019-01-16" version="1">MAERAAQIAGHLNYPKGMLAGQVAIITGSGQGIGAEAARLFANEGAKVVVSDIDAKKSQEVADSINRSGGSAISVPGDMLDANYLKTLVKKTAEFGNGKIHIIVNNAGYTWDGVIHKMTDKQWENIIALHNTAPFKLVREAAPYFRVTDGEPRAIVNISSTSGVHGNAGQANYGLAKAGINGLTKVIAKEWGPKFGVRCNSIAFGHILTRLTAAKEEGAFVTTPDGEKIALGIPGGKGALSDDAHADIPLRRPGTATEAAAAILAAASPLFSYITGQVIMVTGGRNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7F7</accession>
    <name>A0A3D8T7F7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DlpA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_00217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7F7"/>
    <dbReference type="OrthoDB" id="1476984at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047443">
        <property type="term" value="F:4-hydroxy-4-methyl-2-oxoglutarate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008948">
        <property type="term" value="F:oxaloacetate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16841">
        <property type="entry name" value="RraA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.40">
        <property type="entry name" value="Ribonuclease E inhibitor RraA/RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005493">
        <property type="entry name" value="RraA/RraA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036704">
        <property type="entry name" value="RraA/RraA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33254:SF4">
        <property type="entry name" value="4-HYDROXY-4-METHYL-2-OXOGLUTARATE ALDOLASE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03737">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89562">
        <property type="entry name" value="RraA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="145"/>
            <end position="148"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605493-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW94454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="267" mass="28765" checksum="E0F7972E2FA2BB60" modified="2019-01-16" version="1">MHVQAFRSGLLYNNCRSIFALYSHHMNSVKPPFRSMSSTTDQMQALKKYTACDIADALLKLKVPGSGFLSDLQLYPPGSDVSGKEVTIAPASTVEFRPKSSNHTPSAGTRNDANIPVGKHWVDLTESETIVVMSQPDGQRNAVLGGIMALRMKVLGAKAVVVHGRVRDMVELGSTGLPIWARGSSIVGAGAESIPHAIQVPLTLDGTEVNPGDLVFSDPTNGVVVIPKDKVNNVIEMLPKLVKADDRVKEDVEQGMSVQEAFKKHRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7W6</accession>
    <name>A0A3D8T7W6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CST complex subunit STN1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Suppressor of cdc thirteen homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_00377</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Telomere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7W6"/>
    <dbReference type="OrthoDB" id="77828at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018856">
        <property type="entry name" value="Stn1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF33">
        <property type="entry name" value="CST COMPLEX SUBUNIT STN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10451">
        <property type="entry name" value="Stn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0779">Telomere</keyword>
    <feature type="domain" description="CST complex subunit Stn1 N-terminal" evidence="10">
        <location>
            <begin position="49"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="94"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="204"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="235"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW94614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="311" mass="35356" checksum="55D1482843C7EEDC" modified="2019-01-16" version="1">MTSASLSPTIYPVYCHELSPTIGKWCPLRATDVHRVQAVGMVLDGKPLYHFGNHPIKWVRITGVIVAIDVFYQRRVYTVDDSSGECIECTCETPPPSSKTLEALEGPNNQERKAQANNRKKPESSTTSQAPPAKVYMKIADDIDVGSVVKVKGLVTDFRGMKQIEMRSIVPMKGTQEEIRCWNQIMDFRKDILDKPWIVEPAMEEKMKRRSMRPRHRARRTRLEGGQHQRGQGADTKERHSEAAGKQPSHDPYARMRKPEDGYRRSAEKAMLRSKQQKEESRRGLKPANKVNYPSLAVRERVAGKYDALGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T861</accession>
    <name>A0A3D8T861_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_00526</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T861"/>
    <dbReference type="OrthoDB" id="5329749at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="244"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="178"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="246"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW94763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="281" mass="31924" checksum="FEFCF064A4635805" modified="2019-01-16" version="1">MTTQTDSPLSVTSSVAGIFTFVVAIAAAIYARFNYLRNADIEYFEVKASLSWYKTESIWLHDLINAADRPSGNEMEYQMYIFVMDQLGKLEERLLELLTETEIRATSGRDSEGEGGSITSRIAGRRWTLVPEGVRGNTAIAVAWLRVRGKALELVRQRDALGSRVLFAQMSLVSSRVRDQEARQKKREESHRERLERLESTVNAQNEKLDRLEGLVYRTMHRSKIEEGLTAEDRYDQRHHKSLDISSAATSTTASPQPSPPLVKPGMAVRYHQIQEDYKNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8M8</accession>
    <name>A0A3D8T8M8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_00648</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8M8"/>
    <dbReference type="OrthoDB" id="2157498at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029164">
        <property type="entry name" value="PIG-Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400:SF1">
        <property type="entry name" value="PIG-P DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39400">
        <property type="entry name" value="YALI0E29227P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15159">
        <property type="entry name" value="PIG-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW94885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="365" mass="39776" checksum="9CE7EF344B33E35D" modified="2019-01-16" version="1">MEQDSSALNAPPNEDRSPQRPVPPGHKRSLSGSIWRLPFLRPPIDERAKSKEMDPAPPSPEFMPGEDRISTTSPTSPKKPGRAMAVAIQQQKTRRRKGSLRKAALLGRGAQREKRESKMSALDATAPQDAFGGDTTLNATSPDNMPQINTFALGIDTTPRPSMDGYASRDNNTLLSPIKTLPMGHEDHIAPPTASTSPTLTYTSTTDDEDILSIAKHIPPALRNPTSGLPGPDSYFPAGSGSLTRRRSSQKAKSPLSMAGLAASPLPPMPDEWDYSETEWWGWVVLIVTWVVFVTGMGSCLGVWSWAWDVGETPKAPPELEDDPTLPIVGYYPALIILTSVMAWVWVVAAWVGMKYFRHAKISGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8W7</accession>
    <name>A0A3D8T8W7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_00727</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8W7"/>
    <dbReference type="OrthoDB" id="3647at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051999">
        <property type="term" value="P:mannosyl-inositol phosphorylceramide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051706">
        <property type="entry name" value="Glycosyltransferase_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32385:SF20">
        <property type="entry name" value="MANNOSYL PHOSPHORYLINOSITOL CERAMIDE SYNTHASE CSH1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW94964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="274" mass="31782" checksum="58F7FEF75E80DDD1" modified="2019-01-16" version="1">MLRSRFRGVWVLVLFFLFFLWRVVNFIQIFSAHSGPAITQEQIKVAVEANSTGRPEYIPKIIHQVYHDWSGQGMPADWDQVAQKCKDVNPGWAYKGCQESFTPLIYYPAFTTDGGRGALSNNVLGSRPNHPFWKLMTDSLQPYNYDYFFPYVTISWASGQWFETDVWERYQRSHPLREEDQIYRVMMDDRPGSDPWVFFTHERGGTWVNWDNRMFLWIGDHLWLIGLAVGAVIVLPAWVVIMIACPKRKGSSGEDIETAERRASALSKLQGRFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9H3</accession>
    <name>A0A3D8T9H3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Septin-type G domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_00930</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9H3"/>
    <dbReference type="OrthoDB" id="416553at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005938">
        <property type="term" value="C:cell cortex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032156">
        <property type="term" value="C:septin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01850">
        <property type="entry name" value="CDC_Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000238">
        <property type="entry name" value="Cell division control 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030379">
        <property type="entry name" value="G_SEPTIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016491">
        <property type="entry name" value="Septin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18884">
        <property type="entry name" value="SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00735">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006698">
        <property type="entry name" value="Septin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51719">
        <property type="entry name" value="G_SEPTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Septin-type G" evidence="5">
        <location>
            <begin position="27"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW95167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="384" mass="44205" checksum="EB907EA3A94DC51C" modified="2019-01-16" version="1">MATASESASPIGIANLPNQRHKIVAKRGAAFTIMVAGESGLGKTTFINTLFSTTIKNYADHKRRHAKQVDKTVEIEITKAELEEKFFKVRLTVIDTPGFGDYVNNRDSWMPIIEFLDDQHESYMLQEQQPRRIDKIDLRVHACLYFIRPTGHTLKPLDIEVMKRLSSRVNLIPVVAKADTLSPADLARYKQRIRAVIEAQGIKIYTPPIEEDDEAAAQHAKSLMAAMPFAVIGSEKDVKTGDGRIVKGRQYSWGVAEVENEDHCDFKKLRSILIRTHMLDLIHTTEEAHYEAYRAQQMETRKFGEARPRKLDNPKFKEEEESLRKRFTEQVKIEEHRFRQWEQKLISERDRLNKDLESTHAAIKSLEQELETMQGSAVRSHGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q619</accession>
    <name>A0A3D8Q619_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q619"/>
    <dbReference type="OrthoDB" id="3527261at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW57266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="479" mass="52476" checksum="97AE593AF7C2101D" modified="2019-01-16" version="1">MSSYTTPNFSALGSLNIPAFFPVPPLMNIFAEWAALIPLVCHLASYRHAHQFVGQVTLLGRVSVGLFPKLGVLTGISRLIERSPEFLDTASMLGSSSRKVWDVKWGSTFPCANGAASDILAESLLSCGKAAVRIPEEIPSALLPQLAKDTTQCSKESASGAQAKQEPFSIPSNLTTVSSQGPIVRPNIRRYQTLHVLSFSKTKPSSSWHSILDRFFSSPIFEAMAFTCKIGIVVIFCLFGIYGTAATLLSGAVTQLVVRNIQIQRPSGFLGNNEVHDACMLVATHANASTWYLFVGDRGIVDSLLNKPMICIPSQKVAAMWLRNANIIQLLAMTFVAAQKGWDGVSLFVLLVISTIIKLRFSNKFLAKIFCEANGVVATQESFEFSGRTSMLGAIQKLSETRSWAWMDEILTPCARRDVWAKDLSSTDPDLKQFNIEIRNLNDFDRGWVLVNKTLAERAANMMRNAIGGHAEKRVSSCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q6A3</accession>
    <name>A0A3D8Q6A3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative amid-like nadh</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12803</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q6A3"/>
    <dbReference type="OrthoDB" id="202203at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004174">
        <property type="term" value="F:electron-transferring-flavoprotein dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735">
        <property type="entry name" value="APOPTOSIS-INDUCING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43735:SF11">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="1">
        <location>
            <begin position="8"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW57353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="371" mass="39502" checksum="36F09E4DCC5EFDC2" modified="2019-01-16" version="1">MTFPALKNIVIVGGSYVGVNAAQQLAAAFAGRFRVMLIEKNSHFQHLFAFPRFAVATGVDTHRAFIPYVPGTFAACPPGSGAVIQARVSELTKSAVHLDRKVLLDGLPTDSIPYSFLVIATGTKLTPPSSLPGSEKLDGVAYLQKHAQLVKRSSNIVVIGGGAVGVQTATDIKELYPEKSVTLVHSRENVMNKFHPQLHEIIKERCAELGIDMKLGSRVKVPSDGYPTDGSNFKVELEDGSSVPADLAIICTGMTPQSSILQSISPESIDASGFIRTQKTLQISAPERPNIFAIGDVADTGAHKAARPGGKQAAIVASNIQHLLKDEPLENYDGIDPPAIHLTLGIIKSVVFGNPKPGSSDEPMIKNKEDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q6P9</accession>
    <name>A0A3D8Q6P9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q6P9"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017570593" evidence="1">
        <location>
            <begin position="27"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW57340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="63" mass="6925" checksum="6C559625D5BFE70B" modified="2019-01-16" version="1">MQFSLLTLPIIIVMAALASTAPTAEGDGLALSAENEKRSEDVFHRLQVRDHGCPGHVMCKYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q705</accession>
    <name>A0A3D8Q705_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-dioxygenase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_12644</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q705"/>
    <dbReference type="OrthoDB" id="407832at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051961">
        <property type="entry name" value="Fungal_Metabolite_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37563:SF2">
        <property type="entry name" value="PHYTANOYL-COA DIOXYGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_2G03330)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW57194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="38895" checksum="C1135F7C005F8786" modified="2019-01-16" version="1">MTSATDSPRFVNSSTEEQRAKQYGIPNLQLALEGLHQDGMVVLGGVVNVDHCTKLYDYMATDRNRLMEERHANGEGFNQGVQSNILQCAPLTKPELLFDDVNFNPFVIQVLNAYLGYQPRWIFSTGNNALSGTNGMRQPVHKDTRYRHPKCPFLVVANTAICDFTIENGATEFWLGTHAFTDETCQTTVDSKDIQRDATASWKSVIGEPSTPIRPEAVEARRHIRPPIQALMKKGDVMLRDMRTWHAGMPNETDKDRIMLAQAWAAPWYPNYTCRLELPASNAEYFLSRAKSFPMQLQADMVSDKQVEDNQHRDNFRFAPNEYLEHYKTAPKNYKYPFQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q726</accession>
    <name>A0A3D8Q726_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_12664</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q726"/>
    <dbReference type="OrthoDB" id="5376287at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540">
        <property type="entry name" value="TRANSCRIPTION FACTOR (ACR-2), PUTATIVE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37540:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="2">
        <location>
            <begin position="8"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW57214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="502" mass="55931" checksum="F17E83E47A6C76D8" modified="2019-01-16" version="1">MGKTLRRSCAACAKAKHSCDLRTPKCSRCVKRSCACVYANEPLTSTSVPLGDVGHAFRASQISKSRSRPAVLLTGSGESVSPDPSDMSMFFEAHLFDPFDSYPATSLPRLRVQGLMRHFLSKIAFQYYPLDLNPASNPFVTSWWPLALTDPALFHVSLQTASLDDELHASKGFPHSELLMKDSVSLLRHKIQHESLAFQNATMNAVITLAAIEHGKGNLHLSKVHIDGVKRMVTVRGGLTKVRETSPLTARMVAWVSMLVTGSPQFDTQDDAGQGDGVYAIPQWQYSISMETKNPKLVDLDVLGLDPTIGNIIHRLRSVFDLFQTLETPVTLSTTDLHDLACFTLHRMLSLPPLIGQDSLATNTSECFRYGVSLYMFIMHGPTYYSHAHILYGLVLQLEYHLEPIFSLTNVDYSLLVWFLTMGAVASAGTSEIQWFCARAGEITIRLGLQCWDDVERHLKSVLWLETTTRSLFQQIWEDMATLDSSVYRTAPRPLTSSEARD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q7C1</accession>
    <name>A0A3D8Q7C1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_12514</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q7C1"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF32">
        <property type="entry name" value="FAD-LINKED OXIDOREDUCTASE AFOF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017683194" description="FAD-binding PCMH-type domain-containing protein" evidence="6">
        <location>
            <begin position="21"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="7">
        <location>
            <begin position="59"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW57713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="496" mass="53368" checksum="2FD3060204ABB18C" modified="2019-01-16" version="1">MLVRASCLYLLTTALRLVAARSSTSLNLTALYGPGLSSGAEIFYPADADYSTDITPRWNLNDAPTYYGAIKPATEADVQHVVKVSAQNNISFLATGRGHGSTSTLTALHGIGIDLGNFRTIDLDAENNKLTVGGSVNFSQLFEPLSTAGKMLPFGNSRCVGLLGASMGGTVGYLQGVLGLGVDYLDSVRLVTASGDLVEASKTNNSELFWGIQGAGHNFGIVTSATFHLHDNVNGGMLTSMDLLYPGSANQTIYEALKTYDDVIPDELTLNIASVYNATSGQGAIVVNVVWFGPEAELTQHIQPFLAAGPLANNTKTVQWTDWWTVANFGGYTSATASDCVDGQYFNSYALDIKNTDPAVLTAVFNDIVEFSKANPGFSGSFGIDRYPEAVTLSVPNGDTAYAYRDTKSQVTFQSYFGSNSTVNDAADTLFKNARSAVQATSGFDHLAVYVNFAHGDEGPAIWYSPEKLDNLTRLKRKWDPTERFSFYQPVPLYYP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QBM9</accession>
    <name>A0A3D8QBM9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alcohol dehydrogenase-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_12177</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QBM9"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF6">
        <property type="entry name" value="TRANS-ENOYL REDUCTASE APDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="4">
        <location>
            <begin position="17"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW59253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="360" mass="38374" checksum="8423319CADF98B28" modified="2019-01-16" version="1">MAATHVIPQRQMAIIAGPSGDFEVSTSTKVPDLEPGEILVKACAVALNPVDTKLVGSFVTPGCIFGFDCAGVVVAIGSDVHKDLKVGDRVCGSASGMNKEKPLGGAFAEYVKLVGDLTLKVPDHMPIEDAAALGTAIASACMVLFWSLGWPLNLLDGPKAEEPLPPVLVYGGSTSTGTMVLQLLRLCGFPTITTCSPHNFELAQSYGADKVYDYKSADCAKQIRSDTGNLLEYTVDCFAEDSSMRFCYAAMGRAGGHYTALNPYNDLLATRKVITPDWVLATRIAGDGSSWPAPYACEPEPRLREMAGPLFERIQRLLDSGKIRSHFVKLESGGLPGVLDGVQKIRKGEISGQKLVYALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QIF3</accession>
    <name>A0A3D8QIF3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Mandelate racemase lactonizing protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_11370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QIF3"/>
    <dbReference type="OrthoDB" id="2579025at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008869">
        <property type="term" value="F:galactonate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009063">
        <property type="term" value="P:amino acid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034194">
        <property type="term" value="P:D-galactonate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03325">
        <property type="entry name" value="D-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034593">
        <property type="entry name" value="DgoD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029065">
        <property type="entry name" value="Enolase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023592">
        <property type="entry name" value="Galactonate_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018110">
        <property type="entry name" value="Mandel_Rmase/mucon_lact_enz_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013342">
        <property type="entry name" value="Mandelate_racemase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013341">
        <property type="entry name" value="Mandelate_racemase_N_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010624">
        <property type="entry name" value="PRK14017.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080:SF2">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48080">
        <property type="entry name" value="D-GALACTONATE DEHYDRATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13378">
        <property type="entry name" value="MR_MLE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02746">
        <property type="entry name" value="MR_MLE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00003">
        <property type="entry name" value="D-galactonate_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00179">
        <property type="entry name" value="mandelate_racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00922">
        <property type="entry name" value="MR_MLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00908">
        <property type="entry name" value="MR_MLE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0460">Magnesium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mandelate racemase/muconate lactonizing enzyme C-terminal" evidence="5">
        <location>
            <begin position="126"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW61478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="381" mass="42026" checksum="B931C60496438B41" modified="2019-01-16" version="1">MPKIAAIEYFRVPPRWLFVKITDEEGKVGWGEASLEGHTQAVEGCLDAYAERYTGMEADDIEHIWQMSWRLGFYRGGPVFMSALAGIDIALWDLKARRLGVPIYQLLGGKVRDKIKVYAWIGGDRPNDVAGQAEARKSQGFTAVKMNGTEDLGWFDSPSALDDCVERLKAVKALGMDAGIDFHGRVHKPMAKQLAKALEPYRPMFIEEPLLSEHLDGIKALSQHTSTPIALGERLYSRWDFKPFLEAGCVDIIQPDISHCGGISEMRRIAAMAETYDVALAPHCPLGPIALAANIQVDAVSANFAIQEMSLGIHYNVGGQDLTSYTHNPEVWNVQGGYIDLLKGPGLGIEIDEEQVRKFSVDAKAWVSPGFIGPGGEVREW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QIU2</accession>
    <name>A0A3D8QIU2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_11246</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QIU2"/>
    <dbReference type="OrthoDB" id="2125396at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12937">
        <property type="entry name" value="F-box-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="50"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW61354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="415" mass="46637" checksum="2C36B5C12798B610" modified="2019-01-16" version="1">MALDAQSNWDVEMSIPLRIPSSHTPGPKYMEKSKNTVVLLSKPDAHEVLLPAEILSQIISYIPIRPTSQSMLWSCALVSRAWYSAAIARLYQRPYLSGNNFEQFVRTVCPSKNAHIRQSALAVLVHRLDMGELVHNASRSLTARILGRLKGNLEEFVAPQSSFAINSFAALSKCSRLRHLDLSLIASSISNKMLFQTIAHLHHLDTLFFPRSASHDPDRSMVPYTWPPRLRVLHLAGGIDDFFLRTHLIHAPQSLQRLSIQHCPQVHAPNLLYMLEVLGAQLQHLTIRHPMSKLPPGSLDYIFTLCPSLVAVRISADYISDTMFEAIPENHPLRILDLDCSPLAGQDVEVSANAIYEAVEEGRLPDLRSVRVSNRLAWTATERTRSWVRDLEEILEEAEDERPLGIVTGVFSTND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QIZ0</accession>
    <name>A0A3D8QIZ0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_11296</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QIZ0"/>
    <dbReference type="OrthoDB" id="10396536at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12087">
        <property type="entry name" value="TM_EGFR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW61404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="340" mass="37418" checksum="554390509AD54216" modified="2019-01-16" version="1">MPSISSHTLRSLPASISPAVIASIIAGSVILLIIITALALFVYRRRRQSERQYRQGRRNAISAESPLMALPSRNAPPALSLHEVREIYSRENFSLPSSINSSTFNLVSASGSFANDASRNHGAYELDIEPPSSAAGSSYHPRAYPLHSSANSRHSQYPSLNTWRSSNPPIPLHPTQTRIIVTPPTPISPIRRISDSFAWFTTSLVGKKIKGEVNVEVIVPEEGEMEGERGRKIVRRGGVWGLRSVSEEGDDEEEMSMVLNASALAEGEDEKEDPDEALDFTHSDLDRLPLARPRSHIETQNEDAGFDAELDDDYASRLQQISLHSFLASTRESTPGIVEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLS8</accession>
    <name>A0A3D8QLS8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Arginyl-tRNA--protein transferase 1</fullName>
            <shortName evidence="5">Arginyltransferase 1</shortName>
            <shortName evidence="5">R-transferase 1</shortName>
            <ecNumber evidence="5">2.3.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Arginine-tRNA--protein transferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_11064</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>an N-terminal L-alpha-aminoacyl-[protein] + L-arginyl-tRNA(Arg) = an N-terminal L-arginyl-L-aminoacyl-[protein] + tRNA(Arg) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10208"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="Rhea" id="RHEA-COMP:10636"/>
            <dbReference type="Rhea" id="RHEA-COMP:10638"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:78597"/>
            <dbReference type="ChEBI" id="CHEBI:83562"/>
            <dbReference type="EC" id="2.3.2.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the R-transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.8" evidence="5"/>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLS8"/>
    <dbReference type="OrthoDB" id="74183at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004057">
        <property type="term" value="F:arginyl-tRNA--protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017137">
        <property type="entry name" value="Arg-tRNA-P_Trfase_1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030700">
        <property type="entry name" value="N-end_Aminoacyl_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007472">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007471">
        <property type="entry name" value="N-end_Aminoacyl_Trfase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367">
        <property type="entry name" value="ARGININE-TRNA-PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21367:SF1">
        <property type="entry name" value="ARGINYL-TRNA--PROTEIN TRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04377">
        <property type="entry name" value="ATE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04376">
        <property type="entry name" value="ATE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037207">
        <property type="entry name" value="ATE1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="N-end aminoacyl transferase N-terminal" evidence="7">
        <location>
            <begin position="10"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="domain" description="N-end rule aminoacyl transferase C-terminal" evidence="8">
        <location>
            <begin position="137"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="309"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="313"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="326"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR037207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW62762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="416" mass="47879" checksum="0AD8AF8CADD98AC6" modified="2019-01-16" version="1">MPKPGYSYYASTKSLTAECYQSLLNRGWRRSGTTLYKPDQLASCCPQYTIRLDSHGFHASKDQRQSLNRFSRFVQGDEYIKEVTRLYPLSKEQAKKRKTDFDLVERTHESENTQLRTPPTPAHKFEVTLESNDYTEEKYKVFENYQRVVHHEPPTRISRSGFKSFLCVSPICKSTRDFNGQVQNLGSYHQCYRLDGKLIAVGVLDLLPQCVSAVYFMYDESVHQLNFGKIGALREIALAKEEGYQWWYAGFYIHSCIKMRYKGDYAPQYMLDPDSYGWDLLDDRLKAKLDKKEFVGLSRARTKDIQETTAVSNEERLAKDEKEQVENGSDTDSATPDLSTPLFARSMPGILSRSQLETDIDLNHIKLRIRNHDAETCDLMAWEDESIDNPQCLKGIIAELVSAVGPEIAREMIVTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLW6</accession>
    <name>A0A3D8QLW6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter-37</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_10942</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLW6"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF177">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="216"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="254"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="389"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="523"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="63"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW62640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="558" mass="58469" checksum="8D4BCD8AEACA853F" modified="2019-01-16" version="1">MSDLELSRRSSLNNPKSKLGDKGAAPGRLSLGSKDETLNEGVTRVDNDESGDDYPDFMRMVFIVVALILSIFLVSLDMTIVATAIPKITDEFHGLDLVGWYGAAFFLTVGAFQSTWGKAYKYFPLKMSFLVAIFIFELGSLICGVAPTSTALIVGRAIAGLGGAGIGSGAYTIIAFAARPNQRAAFTGLLGASYGIASVVGPLVGGGLCGKGDMEMVLPIGAISAGIVLLFFKTPARAVPEEASWKEKILQMDLPGAFVIMAAVICYVLALQWGGQSKKWSDSSVIGTLVGFVLIVALFVVVEWYQDERAMMVPRLLKDRTIAVGMLFIFFLAGAFFLLLYYLPLYFQAVGGISASSSGIRNLPLILGCTIATILSGGLVSAYGHFVPFLIIGSVLGTIGSGLIYTLGPTSGSSQWIGYQALAGLGLGFALQLPVISAQAVSTPADLSSTTAMILFAQTIGGAFYVSAGQVAFTNVLLKRLTVTAPSISPAAVVATGVTELRNTFLADTIPGIVEAYMDGLKVAYAIAIASVGISIFVALGSKWPWKNLKGVDISGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQ84</accession>
    <name>A0A3D8QQ84_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cytochrome b561 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_10471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW63969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQ84"/>
    <dbReference type="OrthoDB" id="5148443at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="771"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="820"/>
            <end position="842"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="854"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="886"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="917"/>
            <end position="940"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW63969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="996" mass="101033" checksum="78B651AF8948A68A" modified="2019-01-16" version="1">MGAFEQPRQGNSWAQNLVFGSALIFLIWYAVVFQRPSILRVQPAGQVEHHDENAPRLSTLASLESLEEAKNSDEIAQILSITSDFLDALSFQYQIHSLSGLSSDLRAHASNARRSPLVSAASKALESRGLLDGLLGAAGAASRASGASGASVASGGAAMLSGLTSVFGNVASGALAESAQYFGDGIGRGATAGLNISNNAKSSAAPPTGLNAIADNLGFGISNGLTGSLDVSTIASPDTLAAASNALASGLGRGAAAGLGLNKTAIAAPTGTGVALVVGNLGSGLTSSFFKSASLSTFTTSLDVTKLNSAVISAGKGLGEGAARGLNKQVNEAKFDARGLGIRDAANATDSAVTFNAAYAAEDFTQSFSSSFLASIDVKSLLALASSGAASMNLSSSIAPVLVAAGSGLGSGAASGLGAQPLAKSAMSATPDAPVVAHNFAYQLTTSFFANGTLPALATKISSGSSGLPDIRNLLSSAAQVAGSGLGQGLAVGLGLQQTDAQENVMGGDAAIVARQFTFGLTSSFLANGTLTRLQSKGTSVLGNSSMSAMSNSISFSKIAEGAARGLIDGAGSSIRMAGGMQAMMGKKSAANMPASNISANSAKFDDSVGGAASGFGFGLGAESVNLVLEALGQTNSAPAVTAVPGASKPEDNLSSLTVRSVPYAADGVITQQELSPSPSIDLSGGFVGLNITAADTVLQKGVNLLTCKGVGGATQILQGLRDSGALSGGTLPQGFLPNATFSVTNGGNLFNITTGDNMIISVNGVDQRRLVVLLAVHALVLIIAYFVAIPMVLVLENGRTIAVLLMRPQYWVNAPKTKVMIWAFAVLPLALVGFIVGIVLLGSANHFVTPHGVLGLFAIFVTLLAGLFELSLLPESLPFYTRLRATVLTILIALSTFSFVTGFIDIQRISLCTVQLPTAAIIIATMISTSCLIGSIAVAHARWVIQWWASNNDTTRNKVFGDKTDRLPHNFIHVGAEEYAAPLNGYPDTCTPETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQY6</accession>
    <name>A0A3D8QQY6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Galactose oxidase-like Early set domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_10738</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQY6"/>
    <dbReference type="OrthoDB" id="205993at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011043">
        <property type="entry name" value="Gal_Oxase/kelch_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50965">
        <property type="entry name" value="Galactose oxidase, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017671624" description="Galactose oxidase-like Early set domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="454"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="622"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="774"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="827"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="877"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="660"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="777"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="881"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="941"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1039"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1066"/>
            <end position="1090"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW64236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1090" mass="115568" checksum="FF06DD9DE45D9537" modified="2019-01-16" version="1">MKLLLSILLWTLIPYAHAASAPRLPYTPSTLLLQKSLSTTGDLVYAFLPLDSSNAHQLVALNISSNVNVANLSLESVTTSLPFTSDDSTAFIPTISYDGEISVYAGSCSTASSSALWRFTPVNTSISANGTWAQGSTTTASDLTASDLPGADFLSTAFSYSNLADVGAAKTSIFMFGGMCPNSAATTSNWQEAASYSNHMLVLSPSTASDSNAAYTLDLASSKGPPIPEAGFTITGLSPSYTNASGVVTQTQSFLLLGGHTQTAFINMSQVGIWSLPEGSWTFPNVNSPSSQGNTELAVKSIVDRAVTSIDSRSGHSAVLTEDGTSIIVYGGWVGDITTAADPQLAVLNLGTGYGGSGDWIWSVPANQPSGAGLYGHGAVMLPGNVMLILGGHNISTPSSKRARSTSGVTALLFNATSMSWTSNYTNPSYVAAAASAAEAPNSRSSAKETAQKVGLGAGLGLGFTAVIAAFGVYFWYSKRLKQKRIDEREKHISDLSLGAANLYASGQNPEWGMRGPRSFPWSNGGWNTNYEDDHVYNSMSSMAAYENLNFGVHAFGDGSSIPQVGNKQIARKPLHSRARGAYQATPTFEAGTSHARTNSLGTAGPIHPIYEADEDLDNPQYGSSGIRAVGLDRGQSSDDINRESYRYSDPFKDPGAINRSHQVKPTTLTPEHLAQEREREISEWVTDWAAAEALLTHQAKSHSTAGRLSPTKRAQVLAAQNAGYNSEEDSGRTASNLSERSAAVSALTVSRSGSGSGGRSRSDSLRGYIMAPFSSAGGTANQNTVADKSGQRSCTAPKSAGSSGESFNTARTTFPALQAEAEILLPHPDDCGSSRDGSPTRLYAEPLGSPSKNKAHGLSRRGQGGWLGSLRRVFVGEPSHSGQTSPRSPNYSNGEKSPTYINANPGLASSEPRRTVSAGATLWRRKQGRGDWEDSAEGLSMTNTTGRSATFTDGTPPRFNLPIDRGADADADDDWDIEKAVERRVVQVMFTVPKEKLRVVNHDVAEDISDVGSLNSRQGSLKDAVIPPPPLEPESEPEPQASEPPSQSATPKGKETNRLHRPKSRVLEMVEQYEERSSPERSPERSPGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QRI3</accession>
    <name>A0A3D8QRI3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">REJ domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_10770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QRI3"/>
    <dbReference type="OrthoDB" id="10503970at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017695572" description="REJ domain-containing protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW64268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="253" mass="25370" checksum="D2CB2223C3D55D33" modified="2019-01-16" version="1">MKLQLLFPILLATSTLAASSQSSSETAPPTQTSASDFPSGVSISSTTTPSSGLTVSSPTLRSTSLSLSAGSSSISLTLSSETILVSAPPTIYLSAPPNPTTTSAGSETSTVVVHQCMITGRLGSIICTTIPVVYVSDSAISTLSRVTTTSIRPTVSSSNALPYGSSGSVSESVATLSLTLAATPTLTAAVTSTTKVVGVSTVIVSASDTETSSQPTTSIAASTGERGSGSGWATVMYLYFAFALGIQVLFAMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QS00</accession>
    <name>A0A3D8QS00_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_10766</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cerato-platanin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QS00"/>
    <dbReference type="OrthoDB" id="4898945at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd22778">
        <property type="entry name" value="DPBB_CEPL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.10">
        <property type="entry name" value="RlpA-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010829">
        <property type="entry name" value="Cerato-platanin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036908">
        <property type="entry name" value="RlpA-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07249">
        <property type="entry name" value="Cerato-platanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50685">
        <property type="entry name" value="Barwin-like endoglucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017811710" evidence="4">
        <location>
            <begin position="21"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010421"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW64264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="139" mass="14146" checksum="6189661E6F12FCCD" modified="2019-01-16" version="1">MQFPTFNIALFALLTTTATAITVSYDNGYDDGSRSLTAVSCSDGSNGLITKGYSTQGSLPDFPYIGGASTIAGWNDANCGKCYSLTYNGNTINVLAVDHAAAGFNIAQAALDALTGGQAVALGRIDATWAEVASSACGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QTM1</accession>
    <name>A0A3D8QTM1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_09878</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QTM1"/>
    <dbReference type="OrthoDB" id="5126878at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053178">
        <property type="entry name" value="Osmoadaptation_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111:SF2">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G01560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38111">
        <property type="entry name" value="ZN(2)-C6 FUNGAL-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW65186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="414" mass="47171" checksum="2DA4EDE3E09C86D5" modified="2019-01-16" version="1">MEFNIYICYTQKHVRRGAPIDLALQEMQLSDIVAAGTTKANTPIFHQTLLSFAMILFGTQHRQASIAKHGYSIYGAALKKLNYMLQTSKFYSRNDVILSVATFAILECYVPTGPKHYLMHMTGLERLLELRGPTSLCSPKSSQLYKAIRHMILFASLRTGKASILAREEWKAAFRASCSAEEIPEQDLFDVLADCTVLAANYDDILAIRDRDPESSSRQRDEMCREGLALLNQLHIWRARWNSDENNSYFETPIDFAKLELGREPLADELPPFLTTFEFSNNTTAIMLMFYYTTLIHVFRILTSLTLENLRTHSNESFTPDTLQDAGYLDDVWKQIKHGYVAAERSVALQICRCIPDYLKRNSSLATEMSPIFQWTVTTAWMTFRGSESAEGKWLMKLLHTNNREVIAKGLLAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUF7</accession>
    <name>A0A3D8QUF7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_10010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUF7"/>
    <dbReference type="OrthoDB" id="425354at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053037">
        <property type="entry name" value="Pericyclase_pydY-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38115:SF1">
        <property type="entry name" value="LIPOCALIN-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW65318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="187" mass="20939" checksum="FCDDBBAE34D925D3" modified="2019-01-16" version="1">MAAPPEVNIGDLTGKFTLNKSLSDDLDPVLALQGVGWLTRKAIGLASVYLDVKQYVDDQGMVHIDIVQTATAGLGGTTENRTMDWTERDHEDRIFGKVTGKNRLFSFDSVEIDDDYLKEDWLEEGEGTGPSGELHMQGYVVSVNGWTGNQVWGFAMIGDQRRYTRRVVVTKGSEVRRIRMIYDYTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUJ3</accession>
    <name>A0A3D8QUJ3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_10208</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUJ3"/>
    <dbReference type="OrthoDB" id="6075923at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008276">
        <property type="entry name" value="C_nuclsd_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011657">
        <property type="entry name" value="CNT_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002668">
        <property type="entry name" value="CNT_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011642">
        <property type="entry name" value="Gate_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590">
        <property type="entry name" value="SODIUM/NUCLEOSIDE COTRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10590:SF4">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 28 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07670">
        <property type="entry name" value="Gate"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07662">
        <property type="entry name" value="Nucleos_tra2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01773">
        <property type="entry name" value="Nucleos_tra2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="315"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="486"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="519"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="580"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="616"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter N-terminal" evidence="9">
        <location>
            <begin position="234"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside transporter/FeoB GTPase Gate" evidence="11">
        <location>
            <begin position="317"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Concentrative nucleoside transporter C-terminal" evidence="10">
        <location>
            <begin position="420"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="31"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="77"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF07662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW65516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="651" mass="70863" checksum="BBC18B9927FAE3C3" modified="2019-01-16" version="1">MAAPSATPHALDKETAPYVDGSKLPVEEHHAHIHTGHNDPALNPANQHSHEHVNYGHLTHPPDIAFSHDPKHVHKDADVVEKDSSSSDLPPKHTISSEELGRSNSYGETVEPPNKVRAFVRRFRWAIHLFIWCFFTGWWISTLVVHRELGWLKPFLLWLAITIRLLTFHVPLTPVFHLVKKLWRNTVSRGVSMIPEKLRYPLGAAGTVAVILVGTFATQETADNTRSNRAVSLFGLLVFIAAFYATSNNRKLINWHAVIVGMLMQFILALFVLRTSTGYDIFNFIAFLASSLLGFAAQGTAFLTSAASMKSLGWFILNVTPSIVFFVAFVQLLYFWGIIQWLVSKFAVIFFWGMRISGAEAIVAAASPFVGQGESAMMIKPFINHLTLAEIHQVMVSGFATIAGSVLAAYISMGISPVALVSSCVMSIPASIAMSKLRYPETEDTLTSGKVIIPEADEDRPNNALHAFAGGAWLGLKVGVMIATNLLCILALLGLCNGLLGWFARYWGIGLEDETKRLSIQQILGYICYPLAFLLGVERNGDLYLVAKLIGTKIFFNEFVAFDDLSSAAYDSLSPRSRLIATYAVCGFGNISSVGIQIGVLTQLGPKRAGDVAKVAFSALITGVIATLSSASIAGMLITDQAAFASPGPSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUM7</accession>
    <name>A0A3D8QUM7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Endonuclease family protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_10245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUM7"/>
    <dbReference type="OrthoDB" id="276515at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09083">
        <property type="entry name" value="EEP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.10.10:FF:000101">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF36">
        <property type="entry name" value="ENDONUCLEASE_EXONUCLEASE_PHOSPHATASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="1">
        <location>
            <begin position="58"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW65553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="314" mass="35415" checksum="F841C315045C3EB5" modified="2019-01-16" version="1">MARDESLTVSQPGIRITLSVSQEEAPLAESMPVRLITHNIRYATKSPFKGEERWPVRCPRLCSELVFHSTNPRSTFICLQEVLHSQLMDIHTALNADEPESWAYIGVGRNDGKQAGEYSPIFYRPSVWALVNWKTYWLSETPWQPSKGWDASSIRIVTLGVFTHRGTKHTVVVMSTHLDNDGALSRKKSAELILGIAQRYQMSWRPATILLGGDFNSQPDDGAYQVMTSEFSMMEDIGAVIPKGKLYGNTMTFTGFGYVDKTPTRIDFIFSQKGENLTLKTYGVLANRFDDGVYLSDHRACVADLELLPSFYRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUT9</accession>
    <name>A0A3D8QUT9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF6590 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_10224</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUT9"/>
    <dbReference type="OrthoDB" id="3559580at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046497">
        <property type="entry name" value="DUF6590"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20233">
        <property type="entry name" value="DUF6590"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6590" evidence="2">
        <location>
            <begin position="159"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="419"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="419"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="506"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW65532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="531" mass="56784" checksum="DDD04225BCC5D26D" modified="2019-01-16" version="1">MLTEVEDRDNGDYAAERDRAAASSSRHERHRDRRSSYSTARGEVTPSSSRRDQASGGNSRRDAVYSRDFAQSTTARTPVAAQGGTPAYSSGTTNTLSTVNTSQDIATTGLTDAFSQLSTGGYTYTSSAVNSGEPNRVVPGNSTESLPSSYKVRKKDYMEFFRPGRVFSTLWTESAGMRTRRQDETFVSTVRLNEKVVSKVRRFVVVKQSDRACTCLPVTSYDGRGPDKPGITLGDHGHIYSRGQPPIAIPGMQPTALKVHLASGNADFADPSLINYNKVYTVESDVKVKDVGTLDSVSKENLIRCWQGIFCNNPTTTYISSNTSLSTPRYDSSAVLLGSSNSGYNSQPASYSGASSNAPGSSAYESPTAFKQPAYGGASGSSTAQQSQYTGYNRTTSAYGQSSSYAPNTGTSQIAYASQPSYGSQSSYGNQPVYGSQPAYGSQPAYGSQPAYSSQSTYGSQPAYGSQPAYSSQSTYGSQPAYGSQPAYGSQPAYGSQPAYSSQAGAKDEDIVLEPEKGSRSKKSDRHYSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QXT9</accession>
    <name>A0A3D8QXT9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Peptidase S8/S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_09355</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QXT9"/>
    <dbReference type="OrthoDB" id="10256524at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07489">
        <property type="entry name" value="Peptidases_S8_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010435">
        <property type="entry name" value="C5a/SBT2-like_Fn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034187">
        <property type="entry name" value="Peptidases_S8_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF66">
        <property type="entry name" value="SERIN ENDOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06280">
        <property type="entry name" value="fn3_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0720">Serine protease</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017667562" description="Peptidase S8/S53 domain-containing protein" evidence="8">
        <location>
            <begin position="19"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="178"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="domain" description="C5a peptidase/Subtilisin-like protease SBT2-like Fn3-like" evidence="10">
        <location>
            <begin position="657"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="241"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6 7">
        <location>
            <position position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR615500-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF06280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW66606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="960" mass="102732" checksum="2CD1C2DA63EBBEAC" modified="2019-01-16" version="1">MLLSPVAGLIALASLACAANSTSSSFSTRSSTLTNTYIVSLLAGASKSLQGRSPDSGHQAFHKRATAASIKYSVNYQYDAPDLLYGLSIKLENDADAAAIRNMPEVQGVWPVRSIARPQAAIPDAHGPQAEHIAAIQPTNRLLKRSDPQHLKPDGNVNHNTPHTMTGVDRLHSLGIKGKGVKVAVLDTGVDYRHVALGGCFGPGCKVSFGYDLVGDAYNGTYGSYPMPDSDPLATCVTGFHGTHTFGIIAMEESVESTFSGMIGVAPEATVGMYRVFGCTGGASDDVLVAAMIRAADDGADVISMSIGEVVPYANISWSPFEQVVTGLTTRGVAVIAAAGNDGAYRPFNTETPGLANDALSVASVENVGFQTFEMLDSLGKTIRYGSLYPFAKGTLTAILVGSGTLASEYGCTTADHAAAAAKVTGDLSKYVLIVRRGYCPVTTIQAYAAAAGFDNVITFPDDTDPNVFIQGYISPAPYLVGNGSAIVNFGSTTSHIILDGVTSGKNYTLKFGTPNTHISDQIWGGQMSNFSSIGPTWDWKFKPQMAAPGGNILSTYPLDAGGWAILSGTSMATPYLAGVYALVKSQNSTLGPKEIFNVMQSTSKPMIMPGRGDISTVAHQGAGLVSAYDAVTYTSRVSPGQLALGPIEELVSEQPEITITNRADWPVTYRLTHTIANGMKYYPHGEELPGNEGWLNLLFCRLEASLFAASMSFEQSYITIPAGQSQQVPLAITPPQGLSPEEIPIYSGFVTVSSSLGGEQFSIPYMGVGYNYTAAASFGHNTPGPSTNVNDNYRDIFSAPTVYYSGGEEVQNYRRFTLESNDFVGVVSTFLQPTSWMRYDLVRADIELTPTWYGFDQNVTYTNLTKTASPDHMVGGIPIIGNILYYQMNIPTFQVYYGWSGLLYDENYYQIGLLKGSYRILIRSIFTGVNVNDTVYNDVTNWQTFLGPIVEITRDVPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QXY6</accession>
    <name>A0A3D8QXY6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09411</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5423926at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="635"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="981"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="717"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="742"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="781"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="982"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1009"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1064"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1165"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1185"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1206"/>
            <end position="1231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1245"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1337"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1359"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1372"/>
            <end position="1384"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1420"/>
            <end position="1446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW66662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1556" mass="165512" checksum="2B9AC660CCDD73AC" modified="2019-01-16" version="1">MFGNRRRRAASSPPLNSSTANPSATSAATQAFLKSQASNASLSSAAAAAALRSRPTTPISVADVQTKRMMRRMGSTSSMGSSRSGGSSRGPPGASLERRGSVGSMTERTFRDPSPSRSSPVPSAIDAPPVPAIPKNLSQNRASSLEAPHHRVASPIPRTANGRGSSLQPVGHHPPRTAGQRNSISSVADVASPESRGSVNFSYPTGARPQSPVTNSQLTDESYFRPPRITAANNKNLIYDPNTRSFLPAAEIYAIEQKLRDAANAPVKKQKRIAPKQNTGTHLADGTVGGRPKGTAVDAMETARKTQESKAAQQPKPVSDPAPTQEPVVTQSAPKNAIPQTSETETKSVNAPPVPSVSPKKKKKRVTMTESGSDTGSNLGSDYDSDSTRPKTFNPRTGPLPPSALAKKPSVVREDREREEEEDDTPKRLSFQGPYPPILPKNQDQRTVSPSPLPRSRTGRGRGQDLAPAAGMADKPVKTVSQPTTTPISQEPATPVSATNGTNGLKGDAKPARMGSVSPPRTARFATTPENLAVLHQPPNRSVSPRKSAMKHSPSRDDSPSAVGGSEASENSMLDEPPKPKKKSVRVSFDDESNVVVGHAAPSITTDSPVIQSPQIGKSRWFSLSGRGKKKDISALEDDDEVMKPRPALPSFGSIRERKNRDAVDVEERPLVKPADNIVEPTKPTPPTSPIFTSPTGEPIVYPLGHSNDHAMGALVSQDSSARNAANISKSREPLPPEVTSVEGSGYQSDSSSTHSMEEIAEPEAEATNAKAVEITHPEVSESPETPAEAESLPAPHSNGHVPSITVLPATPKAEDEPKQQWLAMPGAWGEVSDAGSQPSSPMAVAEHVPTEPTPAVVGIAEPAPEVVQQAGAPPVGEIASTHYQNGPILEETEDSESGDIYSDAAEDLSDFDGDGFMSLDAVVESPIPKTPATAVATSSPPESPINRLAKEKAYEKMNRDSGPNFGDGWDKAQQYWSGLTADKKRQLEQEAREEIAAEASNDEEKPAPKSKKTKKKVQVQAPNSKQHQPAIYSDRTYMIMPGTRMSPDIPNVVPGQPKPMRTSMRSEPANGNSEPHMRNSMRAAAPTAGGMKSSMREAPVQQRGSLQKRYRPTSLPAADITTNPAAVNKHVRNMSAGATTAQPPPILRRTSSQDSDSSFKRTRAKPESKFRGSMRKSMDEKSPSRSSRFSLRSLSPSGSVARRPFNSQNTSNGPPVSLRSSARDQGNSYDSGAPSLRGPRAMSPSGNSLLSFGRSSKAAPTTKPAPRRSRFADSDSEEDTGRPAFRSRFADSDSDDAELPKTRVKGGFGRGTMRSSAPAPKSAPVRPIPARKGVDDGDSSDLPDSDDEKSPRFAQPTPAKTPQVTNGDATVGSALGSGVVRRSGSGRGTISVPIASSVPGRPNHSRRGSFMSILKRKKPDPNAKIRKSDAESAARRDTPLERSKSDLAALYASPSGSHTPAARPMSPKLQKRNPLSRENSQQAWPLPDSPSLGDPEKDRPFTSDGMANGVGASPVMARRFTATGLSGVDTGMDSFETPRKKKKFGALRKMFRLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QY70</accession>
    <name>A0A3D8QY70_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Peptidase S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_09389</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
            <location evidence="2">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QY70"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF19">
        <property type="entry name" value="SERINE PROTEASE AORO, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10250)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0720">Serine protease</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017653923" description="Peptidase S53 domain-containing protein" evidence="10">
        <location>
            <begin position="24"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="11">
        <location>
            <begin position="375"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW66640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="812" mass="89848" checksum="A4F60ECD2035525E" modified="2019-01-16" version="1">MYLLKQWHVGALFALLWASFSNAIPNPEKARNEHKNQIQVIAGVTVPDTPLVRAAQSYARAHADDMSYNHIMRSWLFGAIMISRSENRSTIDPEVHAVSALLHDLGWDNTGELVSTDKRFEIDGAIAAWNFIEASVKNGTTHSHKWDDNRKQLVWDTIALHTTPSIFVYKQPLVFLTAAGINADFQGPGSDLSGLLTWDDYYQVKASFPRLDLASGVTKIMCGFATNKPATTYGKLLYKEELFRNHQAHRDSDNFMMQFGERYVANYSQNAVGHLGIDEIWVQYDATTAEVEELLIADFYVWEHASGAHDISSEAYQVPKHVQPYIDYVTPGTRLRSRNIRLEPEGGLKERVHAQPLITQLPGFPHPNSSTCDIYVTADCTRIQYSIPNATTAVPGNKLGIFESLDVHYSRVDLDIYFSTLYPHVPNGTYPEERLIDGAIGAIEDTTEYLPIDLEAPLNFDSSWPLIYPQGVVLFQEDDEYYESTGNFNGFWNTFLDAIDGSYCTYSAYGETGDCTAEECLDPAYPDPNPGGYKGQLRCGVYEPTNVISISYSGDESGLPDYYIKRQCNEYMKLALQGTTTVMSSGDSGVGGDVCFGASGKILEVYFASSCPYVLSVGSTEWNRFNSSEPFVPGENLHEVATARFPSGGGFSNVFGIPSYQRDAVATYFDQVESSLGFSGYHQFVANGNFDNITSGVYHHGGRAYPDVEAVGDRQVVYSNVTWWLVAGTSLSSPVWGAVLTLVNEERIAAGKGSVRFVHLVLYQHPEVFNEITSGSNPGCNSTGFPAARGWDPVTGLGSPNFPRLMEVLKAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QZ33</accession>
    <name>A0A3D8QZ33_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_09573</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QZ33"/>
    <dbReference type="OrthoDB" id="6132182at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000065">
        <property type="entry name" value="Putative MFS pantothenate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="244"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="416"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="448"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="478"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="81"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW66824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="528" mass="59761" checksum="D2E717FA580534F4" modified="2019-01-16" version="1">MSSHQIAAQAPAEDTSRATIPADQSTHVVCEAVSGEQAHTSVLSPAPVKSYKYAWFYIFDWYPKYYSALERKTLRRLDGFLITFTGLMFFLKWLDQSNINNAYVSGMKEELKLESNQYSLFGTFYNIGYLVFQVPSLLILSRPGWARWFLPSCEVAWSVLTFAQSRLNSASQIYGLRFLLGILETPVASGSLYVLSSWYRPEELFKRAGVWYVCNNAGAMFGGYLQAAAYTHLSGKLGMAGWRWLFIIDGCISLPIAILGFFVFPGLPASGKPWWMSGEMYRLARNRMHEAGVRDSVKMDMAKIKIMLRRVLTHWHFYIAVLTYTFFLSSGYPNGQMALWLKSEAAHGKGWTVPQINTIPTGVSAVSIVSTVLLTSLCMLYPIGWIITINQWILIFATICMLIWNIPTGLKFLCFYLYGFTAPVTPILIPWVNVIMKDDSEARAFTTGAMLTFGWAVNAFYPILVFPVLEAPRWTKGYAVTLVFVFMVWALFMLGLFLQKRDSKREALAQTGYDEEAKSDVIHIETKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QZ50</accession>
    <name>A0A3D8QZ50_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative metallo-beta-lactamase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_09593</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QZ50"/>
    <dbReference type="OrthoDB" id="449487at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050313">
        <property type="term" value="F:sulfur dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070813">
        <property type="term" value="P:hydrogen sulfide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07724">
        <property type="entry name" value="POD-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.15.10:FF:000033">
        <property type="entry name" value="MBL fold metallo-hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051682">
        <property type="entry name" value="Mito_Persulfide_Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044528">
        <property type="entry name" value="POD-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43084:SF1">
        <property type="entry name" value="PERSULFIDE DIOXYGENASE ETHE1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="2">
        <location>
            <begin position="108"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW66844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="389" mass="43990" checksum="97D558511FC99C6C" modified="2019-01-16" version="1">MKLPLQINRSWQPRVAATATRVPSSSIPRVHIRRPSQLARNKIAWNLQGLKDNSRMRSYGLNCLHQTSFMHAPIRRPQCEMTGQVPYSTKAAIPQEPTIHSIFEEKTGTWQYVVADSSTRDAVIIDPVLDYDPATQIVSARTADSLLSLTEEMGYNIVRILETHAHADHLTAASYLQDHLTRRQGHRPPICIGKRIQGVQRLFSQVYDIPANEYEGVFDKLLDDDETFDIGNLRATAIHLPGHTPDHLGYKIGDNVFCGDSIFHADIGTARCDFPGGNAHDLFNSARKLLGLPDHVKIWTGHDYPPEERGTPVPWMTVHDHKKNNRHLEDGITEEEFVAMRRERDAKLGEPRLLHQSLQVNIRAGHRPKPTISGQSLLRLPLKLKGVEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QZ56</accession>
    <name>A0A3D8QZ56_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF8035 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_09709</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QZ56"/>
    <dbReference type="OrthoDB" id="5410752at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058348">
        <property type="entry name" value="DUF8035"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26118">
        <property type="entry name" value="DUF8035"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF8035" evidence="2">
        <location>
            <begin position="525"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="235"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW66960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="640" mass="76489" checksum="710FA480A49E0C59" modified="2019-01-16" version="1">MSVRGGPRRVAEYEERDTYYRDEAPPVRAPVRTREREETDIYTRRDTRPAFLQDDYSRAEGGPLVLRQRDTETYSRPPRPRSLSPVRRVTETREVVRRDRSPSPVRRVTESREVFRRERSPSPVRRVVESREVLRRERSLSPVRSVARERFIQRSPSPPYREERFRERVVERESSMPPPPDRLTRRVVETREIRRERSPSPVRIRERIIERTRTPSPPPIERVRTRIVEREETRPSPPSLSPSPSPPPPIVRAPPIHQEIITHHRHIDHGFVSERPKVPSPPPPPRSAVGRSKETEIDIYTSRGNTEVDITKTTRNLSPEPPRRRRQEFFEEETYESEREKLRIKDTQVALTRRRSVDSRSDFGLRERERERVRVDIRDDDDEAAYYARKNAERAYIGEAYNGATKDWAIVDVPPGTERVRMDGVGGGSEEITWQRYNGVRRSKFIPEREREPVRERERERLSISDSHSGSGRENTNMEISIRTDNRREGGGGVYEREYERIEESSGNMDRRVGLPRGPRNRVGDLWTEITKDLVIREAIEEMGYDFEETEYFFYVIEYLRYDDVRQLVELSDRIRRERQYRIAQIARERERMEKREREREAYEREREEAWRSTRFDKYDDERIIEREIIYDGRGGRRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R324</accession>
    <name>A0A3D8R324_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative 60S ribosomal protein L38</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_09106</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R324"/>
    <dbReference type="OrthoDB" id="10250488at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022618">
        <property type="term" value="P:protein-RNA complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.90:FF:000001">
        <property type="entry name" value="60S ribosomal protein L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002675">
        <property type="entry name" value="Ribosomal_eL38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038464">
        <property type="entry name" value="Ribosomal_eL38_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01781">
        <property type="entry name" value="Ribosomal_L38e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW68449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="82" mass="9522" checksum="744FEC92AA9980C8" modified="2019-01-16" version="1">MPQEVSDIKNFIEICRRKDASSARIKRNKKTSQTKFKVRCQRHLYTLVLRDSEKVEKLKQSLPPTLIIAETPKKNAKGKRVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R3C1</accession>
    <name>A0A3D8R3C1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_09202</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R3C1"/>
    <dbReference type="OrthoDB" id="3527108at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW68545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="428" mass="48806" checksum="5FA987C5275A264C" modified="2019-01-16" version="1">MAMRKRVWGLSAFPTVFALLLLFCWAYRFSSFASPVGLSPLHNGTPPVEGKKIPEKKPGPIYKDIEKTKNPPAIPIVDNFLLADHFNSTSDFPAIASWNRPPKTHVPEKTPLLIGFTRNWPLLQQCVLSYITAGWPPEDIYVVDNTGTMKSNFPPGKLSLQNPFHLNVDRLVRLFGIKVISTPTLLTFAQLQNFYIFTAQEKGWDYYFWGHMDVVVTSDEDLTLGSDKHLAHPKFESFYMRAVKAIRETQDPGYAAEQKGQWALRFFAYDWLALNNVTTFKTLGGWDTFVSFYLADCDMHERIRMADFKMDTTEAGWVFDVGRSIDINLLFRRKIDPKNPPKTLGELNDLPEDELGGSGFKELRKAIDVETEWKAYGDAYRNAWQVKQAGGQGEPFYRDPRGFAEAMEMAIANGVKTYQEKWGHNTCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R3D1</accession>
    <name>A0A3D8R3D1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Smr domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_08981</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R3D1"/>
    <dbReference type="OrthoDB" id="3231855at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013899">
        <property type="entry name" value="DUF1771"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002625">
        <property type="entry name" value="Smr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036063">
        <property type="entry name" value="Smr_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053020">
        <property type="entry name" value="Smr_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47417:SF1">
        <property type="entry name" value="SMR DOMAIN-CONTAINING PROTEIN YPL199C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08590">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01713">
        <property type="entry name" value="Smr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01162">
        <property type="entry name" value="DUF1771"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00463">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160443">
        <property type="entry name" value="SMR domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50828">
        <property type="entry name" value="SMR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Smr" evidence="2">
        <location>
            <begin position="131"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW68324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="282" mass="31127" checksum="3DC10D8E92493C84" modified="2019-01-16" version="1">MAPHSYPMKQLGPQLGGNATILKQNTTDCAISLVKKQRREDHVSTKYLQSPNPAHRPICSASLQHHPKKTRTNHGMEQAHQAYERGDGAAAHELSEEGKQHAAKMDQYNKQASDFIFRENNAPGRVADDTIDLHGQFVQEAEDILEQRIKYAQQNGQTHLHVIVGKGNHSVNHIQKIKPRVEQVCQELGLQYTTEENAGRMYINLQGGAAVMPPSNSHGGGGGYQGGQQQQHGGYQGGQQQQGGYQGGQQQQGGNDNEELEKLARKFLPKIIRKLEGCCVVM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R3I8</accession>
    <name>A0A3D8R3I8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09138</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R3I8"/>
    <dbReference type="OrthoDB" id="5069016at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW68481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="170" mass="19128" checksum="F03BCD8C5A859F11" modified="2019-01-16" version="1">MAEVIAVMASAVQLANCCAGVWTLIHDIESITPDLQRYKQHIAELLLLSDSILKNEGRIYRVLSFINKKGDLLESLEDIEKKKTSLSLHMHLIQVEFLSEIRDDISAMENKKEKAQNQVGLRRSSPKPVHHHRTSSLVATEIQVSGPEREDTRVVQLQTVPAEEAHQATT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R3Q9</accession>
    <name>A0A3D8R3Q9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Aromatic compound dioxygenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_09283</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the intradiol ring-cleavage dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R3Q9"/>
    <dbReference type="OrthoDB" id="5238185at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018576">
        <property type="term" value="F:catechol 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009712">
        <property type="term" value="P:catechol-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.130.10">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007535">
        <property type="entry name" value="Catechol_dOase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000627">
        <property type="entry name" value="Intradiol_dOase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015889">
        <property type="entry name" value="Intradiol_dOase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050770">
        <property type="entry name" value="Intradiol_RC_Dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711">
        <property type="entry name" value="DIOXYGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G02910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33711:SF5">
        <property type="entry name" value="INTRADIOL RING-CLEAVAGE DIOXYGENASE PRCA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00775">
        <property type="entry name" value="Dioxygenase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04444">
        <property type="entry name" value="Dioxygenase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49482">
        <property type="entry name" value="Aromatic compound dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Catechol dioxygenase N-terminal" evidence="9">
        <location>
            <begin position="42"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="Intradiol ring-cleavage dioxygenases" evidence="8">
        <location>
            <begin position="124"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW68626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="324" mass="36429" checksum="2D7911D0D3A9BF78" modified="2019-01-16" version="1">MATNGTNGTNGTHAANGHSNKAPFDPNFTQHVIDLMSPDTKPRDREILTALIRHMHDFCREVELKQDEWVTGVNYINSLGQAYKKNRNETWRLCDILGIESLVDEINHRVVTDDGAAPTSSTILGPFWSPETPFRDLGASVVQDMPKDGQLTFFHGQIKDVDTGKGIPGAVFDMWQASTNGKYDVFDPENQTRHNLRGKFRTDEDGKFWFYCLKPTEYAIDTSGPSATLLTMMGRHPYRPAHIHMMVSHPDFVGVTAQLYPRDDPYLGTDTACAVKEDLLLDFKPVENEPKGAILDVEYNVRLVSKKYSPESTMLMGNANQDKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R795</accession>
    <name>A0A3D8R795_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_08319</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW69922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R795"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="2">
        <location>
            <begin position="200"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="20"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW69922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="725" mass="82145" checksum="10D1D46A0958A3CB" modified="2019-01-16" version="1">MASSKTRQLECDDSCIRARKRRGLDNRTSKSDQEEHPAFEVSQSTESNSGLQLEKSRTAPTTKLGNVISTHSATTNYGDDEVVCLGSQLRQFHKSSCNEEALESSTTLNIMPAQKKVALQEGIELSDGDAETLDEYDVNDELIFLGPAPLPISRTVSAFRYRQLKFSEIRLVNILPGLESDPVKCQILHVRTDRPLRCSYQALSYAWGAEATGQRVIKIEDQDFLVRENLYQALVHLRYADFERLFWIDAICIDQNNIRERNDQVGKMGRIYSRATDVVVWLGIESRCSRTAFSALERLSMEEGCLAGWTNDSRYKPEFIAIKNISSRPYWKRMWIIQELFRARKILLQCGGDRLEWNTLAQVLRKLSNDDRTSASMACQVLCQSMPAQLHEQRRSNPGSRSLLSLLEMSADSLSSDPRDKLFALFGLAGDITNSTTFREPLLVDYAMSVFDLYEYVMEKYQGTEPIRLSNLLLGFLKEPIRQTHDRYQSQCLSQAPPYHSFHRHTTGLVHLKATRVGRIVEISPTRHISDPSSEYHWFDSCSSISPTVKHELPKAKIMDVFFRHKQAKKNIPFPANIILCKGSTGQLQTTSFDHIPNSVTKYLDFIDQAPSSSLSSSKLSLGPRLFISGHGSWGLVPCSAAEGDMIYRFHNSNRVFITRSILNEDFEVIGRFIVGGCLMIEEREDGRPSFSRSKKHTQHPGKHAAAAPEVEFYLNAMDIQILSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7Q7</accession>
    <name>A0A3D8R7Q7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Topoisomerase 1-associated factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_08466</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the timeless family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7Q7"/>
    <dbReference type="OrthoDB" id="310853at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044998">
        <property type="entry name" value="Timeless"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006906">
        <property type="entry name" value="Timeless_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940:SF4">
        <property type="entry name" value="PROTEIN TIMELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940">
        <property type="entry name" value="TIMEOUT/TIMELESS-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04821">
        <property type="entry name" value="TIMELESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0236">DNA replication inhibitor</keyword>
    <keyword evidence="6" id="KW-0469">Meiosis</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Timeless N-terminal" evidence="9">
        <location>
            <begin position="36"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="566"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="904"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1024"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="576"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="912"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="936"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="972"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1031"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1071"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1141"/>
            <end position="1152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW70069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1174" mass="132925" checksum="9E994A136FED475A" modified="2019-01-16" version="1">MEFANGVKDVVDPEVRAYVSSLVTALGGSGADENGQYVLGDDALACLRDLKRWLKLYDEKANRLDVARCLAESNLVGGDLLQILAAWPENATDDKMKAKIALACLELLVPLTWPIEKNLAQMTVNHHRHIPYLEIAQLGYKRSIINFDGARILNTAVRCALPSMAQSPVDRSTRDEGIIKIVLYFFRNMALIAPPPNVKYDGDEADISRSATIDAFDYQDIFHLLLMMCSTMGEDFNTQDVVVMDILFHLVKGVDIEKLFMTETQLGNSQTDELVELRKKEAALLRGYQKSAPSRHNRFGAMAWISRENSKKTAISGQSAMTDATKGLAKMDSTKKFKPPRRAQKGYTGPMDFDAPVTLSPTATKHLRSFVEDFIDSGFNPLFSHIRKAIDREAERVLEIHSRQFFYLVGWFLEAERVRRKTKAVTRSKSPAASDIESFSLVAGVLNQEMFVTLNKAMDTAYENKVWNDLSASMRCFTQILLTVQEMSECPLEDDQDIAENILSRIFYEETTHDRVANITRTYKDQGFGYLDACTELCHNYLRILEQYSKQNVDLQVRSKRRVRRNKKAARAAGNDEPEDDVIDESENEDEAKAEQASRERKFDFKRFAARFLVQGCVDTFIAFTHFYNDLKPSQLKRAHRYFYRVAFKQEMSVMLFRVDIIALFYKMIKGPEGLDSSLPSFKEWNDLVKQLIKKCTRKMEERPELVVEMLFSKISSTAHFLEYGYDKQTVTSKPRAAAELEVRPNMDWDKQIGIVVSAMLDRNEGDLLQFVKSQLSTSESERRSWEEANKAVQNVEDDPFAEENTTVEVLKPQPSAHVVRPDDARRKIAIFKNGYLRLLMKLVGFELGGVDDDPDGTWIIPSALSADQLKQSIDLINQNEFSPPTFDDGKEASAFIKRVSSGGSRKRQAFDDESDNGIDDDEEPLFPAGGPTAMKKSDALDALKKNRRLRRKRSNDDEDGDLSDEQLQARAEARRARELEKNRKIKSELYVHDSADEDDEERDRLFFEQEEKLRQRSNIIIMKELLGLNKSKDKASGEQSKKRKSTSLLDEESDDDLGVIPTRKRQSSAISIESGNEETSSSSAAENNEDSENEATDTPLSSPHLKSSQSKRQKLSGNDGDAQSAKGLATDQENEPAGVLDEDDDDDEEDMPVARPARQRIRAGFVMDSSDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7V2</accession>
    <name>A0A3D8R7V2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">rRNA biogenesis protein RRP36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_08539</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 10">Associates with 90S and pre-40S pre-ribosomal particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the RRP36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7V2"/>
    <dbReference type="OrthoDB" id="448446at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009292">
        <property type="entry name" value="RRP36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06102">
        <property type="entry name" value="RRP36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 10" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 10" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="43"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW70142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="303" mass="34446" checksum="9A7567B0E001EF10" modified="2019-01-16" version="1">MSSVKRKALGEGLQRRVRARRESSEELESVGSAPSVEDVGSASDDESNDAEEEAQDEESDESSGSESDEAGPDGAASISFGALAKAQASLNSKGNKTKASKKKGNSDDTWENNEAKERKAGRDDKRDFNRSSKHAPTEISSKKAVSRRREVIPVAKRAFRDPRFEALAGDLNESKVQAAYSFLDDYRDDEMKELRAAIKQTKNEDDKEKLKRTLLSMESKKKADLRKKKEHEILDKHRKEEKELVKQGKQPFYLKKSEQKNRLLVEQFGELKGKQLDHVIERRRKKQEGKEKKRLPMARRVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R858</accession>
    <name>A0A3D8R858_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_08626</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R858"/>
    <dbReference type="OrthoDB" id="106623at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000023">
        <property type="entry name" value="Probable uracil phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001097">
        <property type="entry name" value="PRK00129.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="11">
        <location>
            <begin position="43"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW70229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="246" mass="27491" checksum="88F01C4C9AF15328" modified="2019-01-16" version="1">MAAITKNPLSPTQCVGPDYRPESKKPIATVSTEVPFENVHTLPQTPQLIALLTMIRDKNTHRADFIFYSNRIIRLLVEEGLNHLPVVEHAITTPVGRSYAGVQFQGKICGVSIMRAGEAMEQGLRDCCRSVRIGKILIQRDEETSKPKLFYDKLPEDIADRWVLLLDPMFATGGSATMAVEVLMSRGVPEGRILFLNLIASPEGIEPFVKRFPKLRVVTAFIDQGLDEKNYIVPGLGDFGDRFYTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8D2</accession>
    <name>A0A3D8R8D2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_08633</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8D2"/>
    <dbReference type="OrthoDB" id="8119704at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1820:FF:000039">
        <property type="entry name" value="Esterase ybfF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46118:SF4">
        <property type="entry name" value="PROTEIN ABHD11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="46"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW70236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="291" mass="32736" checksum="F61D86DC868E957E" modified="2019-01-16" version="1">MLPRPKLCIPVRAGICRTIRSYSTKNKETVPLAFKLYNPPQKVSAPPIIFAHGLFGSKQNHISHSKTLAAELKRSIYAVDLRNHGDTAHNPRHDYTALAEDVEQFILDHELTQPILIGHSMGAKTVMTVALRSPDMISSIIAVDNSPISVPLAENFAGYIEGMREVEASKVRTPKEADEILKKYEASSETRLWLLANLKKPDPYLKFRVPLDILDRSRGALGDFPFTESDTVVFEKPALFLRAKHSHYVPDESLPAVKRFFPNAEIEDVDSGHWIIQEKPREFQKGFPSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8G4</accession>
    <name>A0A3D8R8G4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Nucleosome assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_08637</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8G4"/>
    <dbReference type="OrthoDB" id="27325at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1120.90:FF:000003">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.1500:FF:000004">
        <property type="entry name" value="Nucleosome assembly protein Nap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="136"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="345"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="147"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="347"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="387"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW70240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="400" mass="45553" checksum="1DC112196CDE6469" modified="2019-01-16" version="1">MSEPIRNRKADVTAPTPQNTPANNAPISSHAQQPGVSSIKEEDFDRSAAAAIFAQNPKLAQLMEGKLNSLVGRSSGYVESLPSVVRRRVAGLKGVQKEHSKLEAEFQEEVLELEKKYFAKFTPLYQKRAKIVNGAAEPTEEEIKAGEEDEEEGESEPAEKETESSEKITGIPEFWLSAMKNQISLAEMITDRDEAALKHLTDVRMEYLDKPGFRLIFEFAENDFFTNKTISKTYFYQNESGYGGDFIYDHAEGDKIEWKEGKDLTVRVESKKQRNKNTKQTRVVKKTVPTESFFNFFSPPKPPTDEEDDDAASDIEERLELDYQLGEDIKEKLIPRAIDWFTGEALQFEEMDDDDMEGDFEDEDDEEDDDLSEDRDDEEESEEEDDATKPKQEAAECKQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8R0</accession>
    <name>A0A3D8R8R0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_08685</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8R0"/>
    <dbReference type="OrthoDB" id="3248508at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842:SF3">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47842">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="102"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="436"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="654"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW70288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="743" mass="81991" checksum="C96016832B5BB357" modified="2019-01-16" version="1">MATEAQLAEKLLQDRRGVRTPPPPPPPPRSEAPGRNGRPPPLPPRQSSPFLAPPPAYTSDDARRSEMISEAWRSYDPRSSSTHSLVPSESGRGRDGRRKLLLIFIHGFMGNETSFQSFPAHLHNLLTVALSKTHVVHTKIYPRYKSRRTIDFARDDFGAWLEPHEDAFTDVILVGHSMGGILAAEVAIQPPRTPATGQPFAHRMLGTISLDTPFLGIHPGLISSGIASLFRPADSPGPKPAQAGNSGASTPSLATQDSVSGTSQRPSAPSSYSGSIYDADSSSQMDRPSPLATPSPTDPYFNKPFTNDVHLPERKGLNSILHFINKHAEGIKTTEKLGSLAAATKSYFTSHLEFGGCLADYPGMKARYSKLRALEDVDDLSTPGAPGYQKPVRRIRFVNYYTASTGRPKQPKIPVGQMIGQDRQLQPIETEMQNMSLSSDSISSTPIPSLDMEDGTSSVTPQQLDQAIIDAPVEIQMQSLGESSGVRDDIQDDELPPMQHIESMPIEEDDESILEPVEQNHMITEAAENATGEPEEATSALEPSSTDPPLPPIPSIPTEPLPIDLSIYTDKDSRKIAEKEHKRAIKAYQQAVKDRDSAIKDRKKLIEKREKKTRQEAEKRLKEEQKQRAREEKEEEKLRTTIKPEPLPVSSPAEAKDPNDSTAKVEKPKKDRKFCMLPPGTDGKRDACWIRIYMEGVDEVGAHCGLFFPGPQYESLVMDVGRRIEEWVDEDIKKRARIDAADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RD52</accession>
    <name>A0A3D8RD52_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08011</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RD52"/>
    <dbReference type="OrthoDB" id="5410926at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39599:SF1">
        <property type="entry name" value="GPI-ANCHORED PROTEIN (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39599">
        <property type="entry name" value="GPI-ANCHORED PROTEIN (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017733167" evidence="1">
        <location>
            <begin position="20"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW71977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="261" mass="25909" checksum="B11ACF95DACDD3BC" modified="2019-01-16" version="1">MRPSLSLLALSILSPTARAFSTPARFEPFVPSSAEALLVGNDTIVPADHELLKRAGSCAANYNSCSSLAAIYSGACCSKTAVCTTDRNANVACCATGATCTGTIASQRPATTVSATATAKYVSNTYFPFPVIPTTYTAAADCTAAYSACQSNFALCTVDLTGGGYGVTVSAIGGGITVAPTATNLGYASATSICGSLSQAACMGLQTSLCAQYGSGTDTTTTAANTVFVVGSSNQAPRPTMGCMAAMGAVGVGLGIAGQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDG1</accession>
    <name>A0A3D8RDG1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aminoglycoside phosphotransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_08123</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDG1"/>
    <dbReference type="OrthoDB" id="3548175at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051678">
        <property type="entry name" value="AGP_Transferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310:SF15">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21310">
        <property type="entry name" value="AMINOGLYCOSIDE PHOSPHOTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW72089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="429" mass="48652" checksum="36D15938E2319ADC" modified="2019-01-16" version="1">MAELIESEVATMKFLKQNSSIPLPDVMGHSSSQSNDIGIPFIITTKAVGSPLSNFVWEPLPEGKKPHKKLPCLKTVDKEKILRQLGAVTAQLLNLPLEKIGSLHEKDGEFLMGKCLSPAFTWYSRDSLGDYVLRGPFKSDKEYYESLIALFRHHAERFPLEHHVLFAPVPQVREFTADSSYRSAVGRWNDFVTVGSKIDSKKNRLDYCTVAHMLRDVVPSISANLQRSFYLMHPDISMSNIFVDDDFNITSIIDWTNSSTVPLSTLLITPSFPHARNEVNSNLVPVFEDSLIHHYSQTNKNILDAQSWDSTRSSWLFMRLVTLDGLQDYNYFVELYTSVFGTTDETTVRRLFNTIQEDHDFMERARTLAKADPSIDEILNEEEDYFCDSASGAEAIARKLTVVASLNQEFIADSKLWRWIEEATSTSGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDH9</accession>
    <name>A0A3D8RDH9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CBF-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_07985</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDH9"/>
    <dbReference type="OrthoDB" id="28947at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040155">
        <property type="entry name" value="CEBPZ/Mak21-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048">
        <property type="entry name" value="CCAAT-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048:SF0">
        <property type="entry name" value="CCAAT_ENHANCER-BINDING PROTEIN ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="3">
        <location>
            <begin position="643"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="38"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="565"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="922"/>
            <end position="1071"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="585"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="938"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="963"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="992"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1018"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1038"/>
            <end position="1060"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW71951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1089" mass="120153" checksum="F24AFCF2CC65034D" modified="2019-01-16" version="1">MPKGDSNATASKKSKKAAGEGLPSFNARALSELTEKIEHKFKKATPKSKYEQADAAKASKNGSSAARDKSETGRGTKRDSQGNAKDSGRGSSFGASKSTKINGRACSDREVLLQEILALGGTEEDLDLVADADSDDEGLTGSEKHAKTLDQSFRNDLAKFVAGLGIESNLALDADEPANQAEETWEDASAGESDMEEEHSEASEPISEDEGEDGPAAEFTAPKEPSRPSATSSKESNRLIFEARADWHAAALPSLPAPVDDSTPPREIVAQIKDYAISLLEADAKLYASKHLSASSSHRFLSTIMSSGTLSDKVSALTLVVQESPVHTTKSFESLLTLAKKRSRGQAVTALGALKDLLGVGVVLPADRRLRTFATQPGLLGTLEKYPLSSWNSGQRLPGNITKAHLISWAFEDWLKESYFDMLKILEGWCNDEIEYARSRAVTYVYELLKEKPEQESNLLRLLVNKLGDPEKKIASRTSYLLLQLQTSHPLMKPIIIRSIESELLLRPGQSQHAKYYAINTLNQTILSGKEEAVAQKLLSIYFELFVTLLKKPNEQKPVNAPVVNRKGQLQGGGAPMGKKAKAKATKEEEAKQASEEATEKMISAVLSGVNRAFPFSKADDVTLEKHMDTLFRITHSSNFNTSIQALMLIEQLATSKNIAVDRFYRTLYESLLDPRLVNSSKHALYLNLLFRALKSDLNVKRVKAFAKRLVQTITLHQPSFVCGVMYLLKELEGTFPGLKMLLNDPEESDEIEEEIYRDVVDDGEVQHNDIMHPDRAEISKRRGHVYDGRKRDPEHSNADKSCLWEIIPFLAHYHPSVSMFAERLVKDEKMPPKPDLGSHTLIHFLDRFVYRNAKAAAGTTKGGSIMQPLAGGDSKGILLSNKAQRAGLQPVNSESFWRKKAEDVAVDEVFFHRYFNQIGKTKQAGPKKTTASRSADDSDVGEDEDEDEIWQALVDSRPEVEGPSDDDDSDLEMMDLDDSDAESDKEVIAADIDDDQEEDKDDFDAGSLSEGSGGIFSDDDDALLDSDDEAPSEIDELFAKELEHAQPKKADEGGEETSRQKRRKLKNLPTFASAEDYADMLKDENEDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDS3</accession>
    <name>A0A3D8RDS3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08075</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDS3"/>
    <dbReference type="OrthoDB" id="416496at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050508">
        <property type="entry name" value="Methyltransf_Superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42912:SF83">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW72041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="402" mass="44723" checksum="83B9868006AFC046" modified="2019-01-16" version="1">MQASCQKFAARSWRATWTEIAHGSVPRTCPGCSRSMSSTSYMQAAKSTKKTPPKAQRVIPEYRTPTRKVAPAAPPKAEPKTNPLRHRTIPIIFGSITLFALSGYCTYLIVLHTRAGSGTSAPSSPAEQADISSRYDSIARSFDAKIEWTEKLMGLEKLRKKLAQRAYGDVLEVSIGTGRNLEFYDWDFKGFQGVGKMDEQNKKLKRGKVRSFTAVDRSAEMLEIAHEKFCRLFPGVIGVRWIVQDASKPIPGPPRSADERSGNKDEKYDTVIQTMGLCSVADPAALLRNLGECVKEDSGRILLLEHGRGEWDWLNGILDRGAEEHAKEFGCWWNRELGEIVKGSGLEIVQLTRKHGGTTWMIELRKPGTKQLDLKDKAGDKVADIKSEAQAAVSPSEKKGWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDU6</accession>
    <name>A0A3D8RDU6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_08150</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000125">
        <property type="entry name" value="Kinesin class 4 (Chromokinesin group)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF15">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="50"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="177"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="472"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="735"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="868"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="908"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1578"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="670"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="959"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1066"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1121"/>
            <end position="1148"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1179"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1455"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1655"/>
            <end position="1744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="25"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="181"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="472"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="875"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="913"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1578"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="8">
        <location>
            <begin position="1588"/>
            <end position="1600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1601"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="137"/>
            <end position="144"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW72116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1753" mass="194595" checksum="6BD8C51D2339B0E9" modified="2019-01-16" version="1">MASSPPGSPSGVNSRPVSAMMRAPRTNSRMSMTSKAGGGSRASDEEGRTSVKVVVRVRPPLMASDPGFDLIPQRFQRSMVQVTPPTGLAIDSPQGKKHFVFDRVFGEDIDQEGLWEYLVESTNAFVQGYNVSMLAYGQSGAGKSYTMGTSGPIDQDDLESMGVIPRAATALFEKLEEPRPSNRNSMSGLRTPTRYSMQPPSMMGKPAEKDWTLKASYVEIYNEQLRDLLVPEHIPAHERGTVTIREDTKGHILLTGLHQVEINSVEDLMKALNFGSTIRQTDSTAINAKSSRSHAVFSLNLIQRKTKSQTTTSAEKRFSVPLEALTGAENTVTIDSKLHFVDLAGSERLKNTGAQGERAKEGISINAGLASLGKVISQLSSRQAGSHVSYRDSKLTRLLQDSLGGNAITYMIACVTPAEFHLSETLNTVQYAQRARAIQSKPRIQQTSDESDKQALIDRLKAEVAFLREQIRSTERSGERQRGHATIERPERQNEREQELQNQLLDTQENYTALSQRHAKLISELAKARDDEVTDNQTMEETLGDSATERLKRSNSFAEAVEQVVLEYEKTIQSLEQSLSSTRSSLSGTEALLLEKETKCAYIETVNQQLQARLQKLMDRESSTEHYLHDLEAKLDGHTSGEEKNSAIVLELRKEIARVRENEANCEDYISTLEERLAEADQDAELMQREIERLEHVVERQRSLGKLDNLLYELDHIQQDGKTIDRDSIGINGKLAKNHSRQQSLASRRGHKTSASKDIILETDDESSDREDLTSPAHGHRSASEGPIDNGEPIEGDLTIQKSVDVNGQYPPASPAQSKFVEDKLETVSQELFDLKVEHESTVNELDILSSKYEDALRTLAELQDAVDEARHGSRQPNPRDSILSASSMITTRPQSFLSDARVNELREGGQFSSSRSLSSELSSFGDLPNSLEHSDAEAAIEKSESGEVAQSVASDETIAAEVEELRKLAVEKERAQKELANKYAKLEEEHMDVLDLVEELKTEMAKAQSNEMSTSRSPTPVIRRKSSQNVMIIDRAHRSFASLRNIATENFEGQPDVMANFELNLNSAMHELHSRSERVQELEADISAVKKEMETKMTIISGLTRERSSMKSSPMDMSVVSTMRDQLMQSENQMRALQEKHAARENELQVEVEALQAAIESHTFANGDKVEGERDDQKTNQDKKITMLEAELASWESRHRGALASMEQSEKQLLKTIAEMENRASLQKERSEGPAQDELVKTMKKELDEHKAAVAATATRIAELEQSHAATKEQLDEVVKSKDLSIAEVESHKSLVSRLEQQIADHEAVVETHQQGLDLLHANHAKEIENIKSTTQADHAAQVADLTSKHESSIAALTSELNVARDALTKVATQVALALGVEASTDKLQDRINGLISDQKSLDAERKKGAEVEKHVIELSAINDSVMKELEGVKAELAAILVTTAEGSKLKAEHATLSDQLGALKKEMSDLETKNQKNSRLVEELEDQLASNFDQHQIANNRLSTLQTERNQQLEEANAAHFRVQSELDAIKEEYATLQAKFEEILPIEGPQTVKRASAQQGQQTQQNLQNLQNGHLRKSASVASLPSPPPAIPLPPLPGSIAATISPSSSAASVPIPPTPNGNRPSSKDLAIQQIQEDQEARIRTIEKHLYAEKQLTSTLEEALTDLERQSNKVKADCDAWRRRAGDLESELKEAKEAAKNGDAEKENRWSLLQVEEERKKRRDAEMARAHLEERMNAISKKKKKGSLNCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJ54</accession>
    <name>A0A3D8RJ54_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Replication factor C subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_07514</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJ54"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031391">
        <property type="term" value="C:Elg1 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.272.10:FF:000011">
        <property type="entry name" value="Replication factor C subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000237">
        <property type="entry name" value="replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF20">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="66"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW74072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="382" mass="42163" checksum="7F027F7E1667B9D9" modified="2019-01-16" version="1">MSNFFDIKARKQAAAANGASSSKAAPAKENNRLQPWVEKYRPKNLNDVTAQDHTITVLQRTLQSSNLPHMLFYGPPGTGKTSTVLALAKELYGPELMKTRVLELNASDERGISIVREKVKDFARMQLSNPSPAYRAQWPCPPYKIIILDEADSMTQDAQSALRRTMETYSKITRFCLICNYVTRIIDPLASRCSKFRFKSLDQGNARKRVEDIAEMEGVKLENGAAAMLIKCSEGDLRKAITYLQSAARLVGAVKTGTDVEDADAMDIDDTNSRVVTVKSIEDIAGVIPDATIDKLVNAMQPKSKGAVYEAVAKVVTDMVADGWSATQLYQSIIYNESIPDVQKNKIVMLFSESDKRLVDGSDEHLTILDLSLRTSNIMAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJJ1</accession>
    <name>A0A3D8RJJ1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DJ-1/PfpI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_07568</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJJ1"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052158">
        <property type="entry name" value="INH-QAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130">
        <property type="entry name" value="ARAC-FAMILY TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43130:SF3">
        <property type="entry name" value="HTH-TYPE TRANSCRIPTIONAL REGULATOR RV1931C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="1">
        <location>
            <begin position="11"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW74126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="228" mass="24770" checksum="28EDF171474C2CDA" modified="2019-01-16" version="1">MASPQSPKYYKVAMLLFSGADILDFCGPAELLTHVSHSDDYTQPDQAFSISYIAGSEIVPAASQLRVVRDRSLEQARADLDAYDIFIIPGAMPDAIMSMINPPSPELAFIRDFIAQPRRLPGQQARIVFSVCTGALLLGAAGAFEGKTATTHHLCVDMLKQICGEHTEVLQRRYVDGGELKNGTRVLSAGGISSGLDATCYLIESLLGVEKMKQATNMAEYERRVVEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPQ6</accession>
    <name>A0A3D8RPQ6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">mRNA 3'-end-processing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BP5796_06806</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the CPSF4/YTH1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPQ6"/>
    <dbReference type="OrthoDB" id="1914176at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1000.10:FF:000012">
        <property type="entry name" value="cleavage and polyadenylation specificity factor subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045348">
        <property type="entry name" value="CPSF4/Yth1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102:SF24">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18345">
        <property type="entry name" value="zf_CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 12" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7 11 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 11 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="14">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="132"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="11">
        <location>
            <begin position="161"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="193"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="193"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU369008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDW75985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="255" mass="28978" checksum="FD2181AB20BEF564" modified="2019-01-16" version="1">MAQILSKGPSPQDLSQQILDHNAPQYTFSFTPFLANTYRHGLSPSRPTCKAYLQGHCPLGGACPDKHTSASSSSNFNNLVCKHWLRGLCKKGESCEFLHEFNLRKMPECNFFVRNGYCSNGEECLYLHTDPSTRIPLCPHYERGFCPLGPVCSKKHTPKTICEFYLAGFCPDGKGCKKAHPRWRTDLEKPTVRVEKTAEEKEEEARELRERMEADEEREREKWRELNGGSGRGGRWEYRGGGGGRGRGQRGRGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RQ47</accession>
    <name>A0A3D8RQ47_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_06946</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RQ47"/>
    <dbReference type="OrthoDB" id="4337792at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051430">
        <property type="entry name" value="Fungal_TF_Env_Response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31944:SF131">
        <property type="entry name" value="HEME-RESPONSIVE ZINC FINGER TRANSCRIPTION FACTOR HAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="14"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="42"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="121"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="57"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="145"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW76125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="731" mass="83286" checksum="1754041798182C49" modified="2019-01-16" version="1">MDPPIRQRRRPALSCVLCRQRKIKCDRKVPCRQCVTSGNQFCTYRSDQQPPRRRYDTASPSAASTSSVNSRRPPGVFVFNASSNTEDNNPIPQHQESPIVRELVNKVQDLEKLLSETKQQNNLANNTLANPDNIDSSVRSSNDPKTPKAEELFSAKARDESTASRSRFFGHTNWMLMFSQFDILQDFSKDPEWNESRALLQQCKATMRAIKSEFKANLFHLPSPRDYIPPRQLCDELVQLYLRTFETTYRILHVPTFMKAYRSFWEDSETADTHFVIKLLLVIAVGAVWYQGDSPLVSRPSTVSWISAARTWLQAPFEKVQLSFDSIQLQCLLALARQANDIGADTFWASASNILTMALNMGLHRDPGMFPGVSVFEAEMRRRVWATVLEFAVQSNPYAGMPLLLSSEDYDCKPPANLDDCDFDETTTTLPESKPTGVFTQTSWQLALLGSISVRINVARLVNKIHSQPTYDEVINLHEALTEAYHAIPSFFRPQNLEPQYTSSNQPTSFQIYMLDHLTRRYLIHLHYLYAARAGRFPQFYLSRKVCLDSSVALLSYPPIATMLPKSSEDFARLRTIGGGMFKEDFFHASILICSELQMQASEEYSYMSNELKRPLLDALDRFLGHVAQRLAMGKDSAKGHFFLSIIIAHLRGRNVQEAAKMSSKMCLAAWDEKLELIRSWQFNGNSSSGNEVANHDPYPDPFQSSLVPEMELNFDISNSWILDGWDYEFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVR1</accession>
    <name>A0A3D8RVR1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATP phosphoribosyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_05995</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVR1"/>
    <dbReference type="OrthoDB" id="15981at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036069">
        <property type="entry name" value="DUF34/NIF3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41774">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41774:SF1">
        <property type="entry name" value="NGG1P INTERACTING FACTOR NIF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102705">
        <property type="entry name" value="NIF3 (NGG1p interacting factor 3)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW78143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="113" mass="12190" checksum="7FA6680C95A7179A" modified="2019-01-16" version="1">MSSPQRYTLTYSVPPSHLEETKKAVFAAGAGSFEDGKYVQVAYESTGTAQFLPVSAKGAVPHTGSVDTLARIEEVRVEIHCGSPDIAKASVAALKQAHPFEVVAYEVYKIEQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVT3</accession>
    <name>A0A3D8RVT3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosome maturation protein SDO1/SBDS N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_06031</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVT3"/>
    <dbReference type="OrthoDB" id="2567806at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF2">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="2">
        <location>
            <begin position="8"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW78179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="114" mass="12489" checksum="23E77A837B635D50" modified="2019-01-16" version="1">MVRGEAIQTKVHYKGTEDDFVIFADSVADVKKWREDKSVPLASVVNSFKIFVTHKQGAQGTLDGASNAILDNEFGTHVDDEVIKIILEKGQLQETEGAERQGSKNDSMGSRAAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWA3</accession>
    <name>A0A3D8RWA3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Sodium/calcium exchanger membrane region domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_06211</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWA3"/>
    <dbReference type="OrthoDB" id="407410at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051359">
        <property type="entry name" value="CaCA_antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266:SF0">
        <property type="entry name" value="MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266">
        <property type="entry name" value="NA+/CA2+ K+ INDEPENDENT EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="770"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="801"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="833"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="857"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="899"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="946"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="983"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="64"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="9">
        <location>
            <begin position="837"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="443"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="651"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="706"/>
            <end position="727"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="530"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="659"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW78359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1014" mass="110571" checksum="1CE8AC9C52C98BC8" modified="2019-01-16" version="1">MLLELDGTRLVKRDEECRLVHHAEDQCAFIKANCPDEEAGLVSYLSLYYCSLAKAQPLAFTILAVWLALLFTTIGIAASDFFCINLSTIASILGMSESMAGVTFLAFGNGSPDVFSTFAAMSSHSGSLAIGELIGAAGFITAVVAGSMALVREFKVGKKTFVRDVGFFIVAASFSMVFLADGFLHLWECCVMIGFYVFYVITVVVWHWYLGRRRKRREREAAARGHFLAPGSEELEVTEEDGDDEDAPAGERPYRDEEDFDALERAASPAFGSQAELESDEDGDEGMHLAAEMASSMRVTRPRGLRRNTITPIRPSLVGALEFRSVLSSLQKSRSSQRPIHLRRYSDDPASLLNTVSGPSSEPAAPSDYASSVIITPADNGEEALRPMPTPRTRAVSMNDVGGPAHLDPAAFNIAVPDIGLVAATPTFPRHLDVEGSGGVSDSLIDMSPVSPTLSISPAPSIDGSEHPDPMMSPERSRSINRNSLAPPAEGIPGARHLRVNRLKDRMDGSNDSPDLSPKSKPRQRPHLQIPSSSRDSSTNRTISPILQFPTYTDSPMPMSGYTSPSVPSIILPEPTLTSDSIYAGMEEDSTEAPIRWWPYQVLPSPYVITSSLFPTLCTWTEKSVWDKFISIISAPSIFLLAITLPVVESDSQEDGPEEHDHTDDRRDNLGRERRRSTAPLLSPVSPSLLANLEPEWERYRRSTIVSEHRNSRTSSPQPRGISGHSGTAGVAVEIEDHHHHHHQHSMPLKTPSITHIDSKTEPSRDWNRWLVAVQIFTGPLFVVTIIWANSAEGPDSSRLLLHLILYSLLGSLIVFGILVLTTTPEKPPRYRFLLCFVGFVVSIAWISTIANEVVGVLKAFGVILGISDAILGLTIFAVGNSLGDLVADITVARLGYPVMALSACFGGPMLNILLGVGISGVYMTISEANRNHAKHPHKSLKYKPYQIEVSGTLMISAITLLFTLVGLLIMVPLNKWVMSRRIGWSLITLWSISTVVNLAVEISGAWPDGGTAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWL7</accession>
    <name>A0A3D8RWL7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">beta-galactosidase</fullName>
            <ecNumber evidence="3">3.2.1.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_06267</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.</text>
            <dbReference type="EC" id="3.2.1.23"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the glycosyl hydrolase 35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.23" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWL7"/>
    <dbReference type="OrthoDB" id="1657402at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004565">
        <property type="term" value="F:beta-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.260:FF:000065">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000040">
        <property type="entry name" value="Beta-galactosidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.20.10">
        <property type="entry name" value="Beta-galactosidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.390.10">
        <property type="entry name" value="Beta-galactosidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018954">
        <property type="entry name" value="Betagal_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037110">
        <property type="entry name" value="Betagal_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025972">
        <property type="entry name" value="BetaGal_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036833">
        <property type="entry name" value="BetaGal_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025300">
        <property type="entry name" value="BetaGal_jelly_roll_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031330">
        <property type="entry name" value="Gly_Hdrlase_35_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001944">
        <property type="entry name" value="Glycoside_Hdrlase_35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23421">
        <property type="entry name" value="BETA-GALACTOSIDASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13364">
        <property type="entry name" value="BetaGal_ABD2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10435">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13363">
        <property type="entry name" value="BetaGal_dom3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01301">
        <property type="entry name" value="Glyco_hydro_35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00742">
        <property type="entry name" value="GLHYDRLASE35"/>
    </dbReference>
    <dbReference type="SMART" id="SM01029">
        <property type="entry name" value="BetaGal_dom2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117100">
        <property type="entry name" value="Beta-galactosidase LacA, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017572188" description="beta-galactosidase" evidence="9">
        <location>
            <begin position="20"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-galactosidase" evidence="10">
        <location>
            <begin position="381"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW78415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="990" mass="107741" checksum="B2E25C268F37B5D3" modified="2019-01-16" version="1">MRFSCLFLALSALLWTAWSTDDGLTDYVTWDPYSLSINGSRVFIFGGEFHYQRMPVPEMWPASDIFQKYKASGLNALSIYFFWSYHSASKGTFDFETTGKNVQRMLDSAKEAGLYVIARAGPYSNAETSGGGLALWGSDGSLGTLRTSDETYHQAWLPYITAIGKIIAANEVTKGGPVILNQIENELQETTHSATNTLVKYMEQIEAAFLAAGVTVPSTHNEKGERSMSWSTDYLNVGGAVNVYGLDSYPGGLSCTNPNSGFNVVRNYYQWFQNYSYTQPEYFPEFQGGYFTAWGDPNFYDDCVSTLSPEFADVYYKNNIGQRTTLMSLYMAFGGTNWGHSAAPVVYSSYDYSAPLRETRELRPKMSQTKLIGLFTRVSKDLLKTDMIGNGTGYAVSSTAVWSWVLRNPDTQAGFYTVQQASTPSRSSVTFSVNLNTTLGLVTVPNVNLNGRQSKILVTDYTFGTNTLLYSSADILSYGVFDTDVLVMYLDEGQVGQFAFKTTKSYTYEVYGASNITSLATNGTQSFVYTQAAGSTAVKFSNGVLLYLLDLPTAYTFWAPATTLNPDVAPNEQIFALGPYLVRSASITHGVVHISGDSDNSTTIEVYSGDPTVQTIVWNGIRLAATKTAYGSVTAQIPGAQERTVSLPALTNWRGANSLPEASTKYDDSKWIVCDKNSTLSPVAPLTLPVLFSSDYGFYSGQKIYRGYFDGKNASAVNITCSGGLAFGWSAWLNGVLIGGHPGNATLTTTNAVLPLTLSALQSTNNLITVVVDYHGHDETSTAKGVENPRGILGASLVSATSTRTNTGFKLWKIQGNAGGSANIDPVRGPMNEGGLYGERVGWHLPSFPYTSSAAFTSTSPTTGLTKSGINFYITTFHLNIDSDLDVPLGIELSAPAGTVARVMIWVNGYQYGKYVPHIGPQTKFPIPPGVINNRGLNTVALSLWAMNDAGAKLDAVELFAYGKYQTAFKFNADWSYLQPGYDVSRLQYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2B7</accession>
    <name>A0A3D8S2B7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_05104</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2B7"/>
    <dbReference type="OrthoDB" id="40579at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050758">
        <property type="entry name" value="Znf_C2H2-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234:SF10">
        <property type="entry name" value="RIKEN CDNA 6720489N17 GENE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23234">
        <property type="entry name" value="ZNF44 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="3"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="5">
        <location>
            <begin position="373"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="305"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="305"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW80406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="406" mass="46493" checksum="92D25586C7932687" modified="2019-01-16" version="1">MPFECSDCERSFSNQEALCQHCEAKVHQVRWYCACEQKYTTAKKLRSHIRKTHPHYCNHCVRIFDDEYGIEQHKKAKHAYKIQQELASTLERTVKERYYQCQVCEFCCMTTDFNHTASLHYQTDHQLPCKTCSEIFETEEKRAEHGLVHKLSCIHCEDAVFSTKEELECHDRERHEFLRTTCKKDKQDKQDKRAAEEKLTLGGVQEQFVAERDRLEARNYTLSRQIRTAQQQAVGSGETCIAMGKLLGDAMAKNYLAELEVRQLRQQVDVLLQESKRRSRSDTSEAGTGTLSALASDKEFAVERTISTQSAQGTGTEELSTSVTDDENVPPTMSSASSTSNDDSIRGNMSTSTHVMGYSLFERFPKILEQQILGCFECGEDFATQSDLLRHLGAKRHETEWLVVPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2U1</accession>
    <name>A0A3D8S2U1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="8">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_05092</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the tannase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2U1"/>
    <dbReference type="OrthoDB" id="3039123at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030600">
        <property type="term" value="F:feruloyl esterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011118">
        <property type="entry name" value="Tannase/feruloyl_esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938:SF16">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33938">
        <property type="entry name" value="FERULOYL ESTERASE B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07519">
        <property type="entry name" value="Tannase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0719">Serine esterase</keyword>
    <keyword evidence="4 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017494040" description="Carboxylic ester hydrolase" evidence="8">
        <location>
            <begin position="22"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW80394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="586" mass="63582" checksum="8C88D6F64A1CE339" modified="2019-01-16" version="1">MTAGSMLALTAAVALWQQNATLNDVCTAAYVKSALPSSSTYPGVVVNPASVLANPVTNANVSGENFFPDATFDYCNVTFAYTHTGRNDTVNVRYWLPAPASFKNRYLSTGGGGYAINSGYGDLPGGIIYGATAGATDAGFGNFSTNLDAVNLIANNTVDWERIHMFGYEAIHELSVLGKAFTKSFFAMNTTKLYSYYQGCSEGGRDGWSQVQRFADEWDGAITGAPAMRFAFQQTQHLYSNIVEQTLNYYPPPCELEMITNLTIAACDPMDGKTDGVVSRSDLCKLNFNLNSTVGQAYYCAATSASSGMGSGSPFGASAATPAQNGTITAQGVAVAQTIIDGLKDLSGKQVYLSYQPGAVSFDDAKTAFNNVSNKWELSVNSFGAEFIARFINDQELETLPNLNNVTYDTLKGWIYQGWQKYADTLHTTWPDLTAFQAAGGKVLHFHGESDNSIPTASSVHYHESVRNVMYPNMSFNDSSAAMSDWYQLYLVPGAAHCAANTNQPNGPFPQTNLAVMIDWVEKGIKPTTLNATVLQGSNKGQNEQICAWPLRPMWSNNGTTMNCEYDQASINTWLYTFDAFKMPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2V8</accession>
    <name>A0A3D8S2V8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_05317</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2V8"/>
    <dbReference type="OrthoDB" id="10263751at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000245">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="site" description="Deprotonates C-terminal active site Cys" evidence="4">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="4">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="4">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="5">
        <location>
            <begin position="31"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW80619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="109" mass="11550" checksum="040C88D929BC3D8C" modified="2019-01-16" version="1">MGVHNLSSKAEFTGALKDNQIVVLDAFATWCGPCKAIAPQVVKLSEAFPAAHFVKIDVDEVPDVAQELGIRAMPTFLIFKGEEKIAEVVGANPKALEAAIAKACEEAKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2Y0</accession>
    <name>A0A3D8S2Y0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_05337</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FKBP-type PPIase family. FKBP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2Y0"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.50.40:FF:000050">
        <property type="entry name" value="Peptidylprolyl isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050689">
        <property type="entry name" value="FKBP-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516:SF443">
        <property type="entry name" value="FK506-BINDING PROTEIN 59-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10516">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="49"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW80639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="143" mass="15349" checksum="F00BCCF6775A0317" modified="2019-01-16" version="1">MFPLISRLSNTTRTQASFSRLRQFSSTAAAMGVTKTILKEGDGAIPKVGDKVTIEYTGFLKDTSKPDNKGAQFDSSVGRGAFVTAIGVGQVIKGWDEGVTTMKVGEKATLDITSDFAYGDRGFPGHIPARADLLFDVELQKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S314</accession>
    <name>A0A3D8S314_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NECAP PHear domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_05391</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S314"/>
    <dbReference type="OrthoDB" id="10265489at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13228">
        <property type="entry name" value="PHear_NECAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000465">
        <property type="entry name" value="Adaptin ear-binding coat-associated protein 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012466">
        <property type="entry name" value="NECAP_PHear"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847">
        <property type="entry name" value="ATP-BINDING CASSETTE ABC TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12847:SF9">
        <property type="entry name" value="NECAP-LIKE PROTEIN CG9132"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07933">
        <property type="entry name" value="DUF1681"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NECAP PHear" evidence="2">
        <location>
            <begin position="17"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW80693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="269" mass="28812" checksum="0B67EF8A8883555D" modified="2019-01-16" version="1">MESIDPSTGRPLPPDAIQRVLFIAPSVHVYNIPPLTSNKGYVAATWTADNNKRQIFTARVRILETAIPQPNGEESVKTDVLLEDPSNGQLFAAAPYIVASVVEQVLDSSRFFAIRVQGEGGRKAVLGIGFEERSEAFDFSVSLQEVRKTLGLENAGMPSTGKKAAKPAEPVSEKKDFSLKEGETITVSIGGRGMGRRHPPKSEETNQGSGGFSLPPPPISGGGLGSFLPPPPSASEVKAQKRLSQNMEMPKAGTMEDLGFDDGEFGEFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S318</accession>
    <name>A0A3D8S318_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HTH APSES-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_05377</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S318"/>
    <dbReference type="OrthoDB" id="3516057at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030907">
        <property type="term" value="C:MBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033309">
        <property type="term" value="C:SBF transcription complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.260.10">
        <property type="entry name" value="Transcription regulator HTH, APSES-type DNA-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036887">
        <property type="entry name" value="HTH_APSES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051642">
        <property type="entry name" value="SWI6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003163">
        <property type="entry name" value="Tscrpt_reg_HTH_APSES-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828:SF10">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN YAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43828">
        <property type="entry name" value="ASPARAGINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54616">
        <property type="entry name" value="DNA-binding domain of Mlu1-box binding protein MBP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51299">
        <property type="entry name" value="HTH_APSES"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH APSES-type" evidence="2">
        <location>
            <begin position="168"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="HTH APSES-type" evidence="2">
        <location>
            <begin position="287"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="HTH APSES-type" evidence="2">
        <location>
            <begin position="398"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW80679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="742" mass="82251" checksum="BAAEB7ACEB4FD8FA" modified="2019-01-16" version="1">MLTFIRGRRTGKVTVFPDSRPFPFEGDSRYNSSLSDNDLLNKLRALEEEVLITRTALKKRGVVEFYDQQTKARNDEGSEASSGFVSTTPQSPDKAHDLKSAFPERSSKRYKIEDSATNTVIPHRKDSFVLTGAYTKPEAKGQTTAYSSTSQANTVSPQDNTRVTKSPPLQIINVAGEFCYIFKCSRDVIVMKRVRDSWINVQQVWEAALLPSDVIYKKRCAQRLLGNSEPKFGPRNRARGLWISFETARDIIIEHGLAEILSPLLLEHSTTPGLPYTKAHLVGDGKAYTTYHEGVPYLLLRTNLGTVGRRTDTQWINCSMIAKVAGLGTVDRVKETDLIRRRVICDIVNGGNSAFQGCWASFGVGLALARKLQVEDLLSPILSDIPISDEDMPAEADPIRVLKSSGKAYYLLETMKGSVTQRISDNWWNASNILKISGLTGSALQKETALLRVGKNEIQFASGNYICGTWAPFRKGVKLALKHNVLELLALLLPDNGEYQLPMTDEDDDEESPMSLEEKWLELKATRHGKVWLPAPTFAENSTTASEIEGTRATQSSILNSVQAPILESRNEDEVPQLYPSDQKALLSPIFPSRVGQICIVSRNTDFRKNGRARLIRDGIATAESYCKAFMIKPINTTMAVGFNATRSIMPALSSTAHGSNNDYYRDCQRMIEAVMSTPPGTQCIIIIRGIDGYTTDLQSLVDFRNASPEIDLWICSAVPKSWTFSPAWRDAGTAPGTIISV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S350</accession>
    <name>A0A3D8S350_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase-20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_05420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S350"/>
    <dbReference type="OrthoDB" id="10017101at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861:SF3">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14390)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43861">
        <property type="entry name" value="TRANS-ACONITATE 2-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW80722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="245" mass="27177" checksum="2ADB7C18ED7BBE72" modified="2019-01-16" version="1">MSNATDRFNAEAAAWDSNPDVQLASTLGFQSLLAKIPWLEKKNPNLDVLEIGCGTGILSLMVSPYVRSLTGVDVAEGMITALKLKLSKSENAWAKNILPVYADLKDPDDERLRPDPLHPDQKDLGPRRFDLVISHLVLHHIPSLEDILKTMYGCLNSGGAIALIDFEDFGLEARKFHPEAKMEGVHRHGISREGMKKLIEEAGFVKVRIETAFVMEKNIEENPGEGVVKGNKMAFPFLICMAEKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3L8</accession>
    <name>A0A3D8S3L8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20 21">NADPH--cytochrome P450 reductase</fullName>
            <shortName evidence="20">CPR</shortName>
            <shortName evidence="20">P450R</shortName>
            <ecNumber evidence="20 21">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="primary">cprA</name>
        <name evidence="24" type="ORF">BP5796_05362</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="24 25">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="20">This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 20 21">
            <text>2 oxidized [cytochrome P450] + NADPH = 2 reduced [cytochrome P450] + NADP(+) + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24040"/>
            <dbReference type="Rhea" id="RHEA-COMP:14627"/>
            <dbReference type="Rhea" id="RHEA-COMP:14628"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:55376"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
            <dbReference type="EC" id="1.6.2.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="20">Binds 1 FAD per monomer.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="20">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
        <text evidence="20">Binds 1 FMN per monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="20">Endoplasmic reticulum membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Mitochondrion outer membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="20">Cell membrane</location>
            <topology evidence="20">Single-pass membrane protein</topology>
            <orientation evidence="20">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="20">Belongs to the NADPH--cytochrome P450 reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20 21">In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="20">In the N-terminal section; belongs to the flavodoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="20 21"/>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3L8"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006696">
        <property type="term" value="P:ergosterol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06204">
        <property type="entry name" value="CYPOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.990.10:FF:000009">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000100">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000111">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000024">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.80:FF:000018">
        <property type="entry name" value="NADPH--cytochrome P450 reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03212">
        <property type="entry name" value="NCPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023208">
        <property type="entry name" value="P450R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000208">
        <property type="entry name" value="P450R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 20" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7 20 21" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 20" id="KW-0274">FAD</keyword>
    <keyword evidence="3 20" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4 20" id="KW-0288">FMN</keyword>
    <keyword evidence="2 20" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="14 20" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="16 20 21" id="KW-0472">Membrane</keyword>
    <keyword evidence="15 20" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6 20" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="9 20 21" id="KW-0521">NADP</keyword>
    <keyword evidence="12 20 21" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 20" id="KW-0752">Steroid biosynthesis</keyword>
    <keyword evidence="18 20" id="KW-0753">Steroid metabolism</keyword>
    <keyword evidence="13 20" id="KW-0756">Sterol biosynthesis</keyword>
    <keyword evidence="17 20" id="KW-1207">Sterol metabolism</keyword>
    <keyword evidence="5 20" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 20" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="20">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="22">
        <location>
            <begin position="65"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="23">
        <location>
            <begin position="273"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="71"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="122"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="200"/>
        </location>
        <ligand>
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="292"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="448"/>
            <end position="451"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="466"/>
            <end position="468"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="483"/>
            <end position="486"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="549"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="611"/>
            <end position="612"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <begin position="617"/>
            <end position="621"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="653"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="691"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="PIRNR" id="PIRNR000208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="RDW80664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="692" mass="76529" checksum="1609DE1F408998B5" modified="2019-01-16" version="1">MAQLDTLDIIVLAVLLVGTVAYFTKGTYWGLAKDPYATSYTAANGNKPAKTRNIVEKMEESNKNCVVFYGSQTGTAEDYASRLAKEGKSRFGLETMVADLEDYDFDNLDSLPEDKVAMFVLATYGEGEPTDNAVDFYEFITGEDVSFANASEPALGNLKYVAFGLGNNTYEHYNSMVRNVSAALQKLGGQLIGTAGEGDDGAGTMEEDFLAWKDPMWTALAEKMGLEEREAVYEPVFGITEREGLTKDSPEVYLGEPNKMHLEGTQKGPFNAHNPYIAPIAESKEIFTVKDRNCLHLEIDISGSNLSYQTGDHIAVWPTNAGKEVDRFLNVTGLLSKRDSVIGVKALDPTAKVPFPTPTTYDAVVRYHMEICAPVSRQFIATLAAFAPNEAAKAEMTKLGSDKDYFHEKISNKYYNIAQALEEIGGGQQWTEIPFSAFIEGVNKVQPRYYSISSSSLVQKNMISVTAVVESLDVPGRPDALKGVTTNYLLALKQKQGGEPNPDPHGLTYDIMGPRNKYDGCHVPVHVRHSNFKLPSDPSKPIIMVGPGTGVAPFRAFVQERAAQAKAGETVGKTLLFFGCRKASEDFLYSSEWEEYKQALGDKFELITAFSRDGPKKVYVQHRLKEHQKEVNELLLQKAYFYVCGDAANMAREVNTMLAKIMSEERGIPETKAEEIVKSMRSANQYQEDVWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S9Z1</accession>
    <name>A0A3D8S9Z1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Tat pathway signal sequence</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_04442</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ustYa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW82951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S9Z1"/>
    <dbReference type="OrthoDB" id="3687641at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043386">
        <property type="term" value="P:mycotoxin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021765">
        <property type="entry name" value="UstYa-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365:SF13">
        <property type="entry name" value="TAT PATHWAY SIGNAL SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33365">
        <property type="entry name" value="YALI0B05434P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11807">
        <property type="entry name" value="UstYa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00035112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW82951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="33337" checksum="CD5D63E0DF13D7E4" modified="2019-01-16" version="1">MSPFVNLEDSRTMYNPLSNKSESSDHDGASEDCETLLSDDSGTSYKRPASRRRFLCLYIAAVPFIAIGLVGFGVWIGARWFANPEAICPSYYQQYSPILKEVDQSVQLVQFNGSFMKESDFRLEAGPKVDAAWASLGVGYRSLAVPESEAAATGLKPDQVKINSKYGGGYPANVEGLHHLHCLNLVRQSLYYNYDYYHARGEGAFTNDDNIVKYHVSHCLDIVRQRLMCQPDTGLLGQVWWDRHAPKAFVDFNTDHKCKNFDAIRQWAEDRQISETVPSDFLQPPKDGDTIYEAIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAJ7</accession>
    <name>A0A3D8SAJ7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_04883</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAJ7"/>
    <dbReference type="OrthoDB" id="6329284at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF40">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW83392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="23674" checksum="B81F1A91F418B9BE" modified="2019-01-16" version="1">MPLRKGPLTLHGGCFCRTIRYTINIPAFSERPVLEKAPQAPLGPQTEIEKRLPVITVDHCHSCRHATGVLMQNWVICPQRWVEFTVTTKDIGGEEQERTHVPTQDLIAPSADLQGKCSIRSFSSSEHAVRTFCGTCGTNLFFYYGGPDNEMAKPENWGPYCDITLGSLDEEFLKMEELRPARQVHRREAVGWLGEVLDGATEVFRGEGEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SBI6</accession>
    <name>A0A3D8SBI6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CN hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_04609</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SBI6"/>
    <dbReference type="OrthoDB" id="412018at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.110.10">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050345">
        <property type="entry name" value="Aliph_Amidase/BUP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003010">
        <property type="entry name" value="C-N_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036526">
        <property type="entry name" value="C-N_Hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674">
        <property type="entry name" value="NITRILASE C965.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43674:SF12">
        <property type="entry name" value="NITRILASE C965.09-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00795">
        <property type="entry name" value="CN_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56317">
        <property type="entry name" value="Carbon-nitrogen hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50263">
        <property type="entry name" value="CN_HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CN hydrolase" evidence="2">
        <location>
            <begin position="5"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW83118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="343" mass="37893" checksum="95CBAC59B4468E14" modified="2019-01-16" version="1">MPRTLKIAAAQMGPIHLTSKREDTIQRMLTLLTSASKLGAQLVLFPETALTTFFPRHLITSPEELESYFDSASTITTAPNTKPLFDEAQKLGIDISVGFAERDTDGQGYNTCVYYSAKKAKVIAKYRKVHLPGTKEPFENPDAVNQLEKRYFTPGNLGFQAFRAPDLVPGAAKKGAEVKAGTGDPILGMMICNDRRWAEGWRCYGLQGVEIVLCGYNTAGFAPDLWGTRKPMTPEEAEIDAVFHHKLVMQGNSYMNSCFSVSAAKAGMEDGKYDLIGGSCITSPEGHVLAEAKTKDDEIVFAEIDLEDCRQGKEKTFDFVRHRRIDQYGPITTQTGVVEPEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SBS8</accession>
    <name>A0A3D8SBS8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxymuconolactone decarboxylase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_04699</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="5537330at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
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        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AhpD-like"/>
    </dbReference>
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        <property type="entry name" value="PTS1_Protein"/>
    </dbReference>
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        <property type="entry name" value="CONSERVED MITOCHONDRIAL PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28180:SF2">
        <property type="entry name" value="PEROXISOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW83208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="252" mass="27612" checksum="00EEAFA25ECDC0C3" modified="2019-01-16" version="1">MTRAFLTPALLSSISQQPHLPKDSWYFVVATTLCILNRPDQIPTVFQHAVENSIQGGEQSLKQESQLFIARRIRESLIKASAVGGVPKTINALHALKTATPAELQDGPFAPSPSSRRGDLYDTPVSDILQRGQDFFEKIYGKIWQRIMEHMDGSGTEDLGLIGRLTYGYVLSNVNILNHRETSFVLIAALVPQDVNPQLKGHLKGALNGGASVEEVKAVRSIVISVCKAAGMTQLDPDRPGGWGWREEVADL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SH34</accession>
    <name>A0A3D8SH34_9HELO</name>
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        <recommendedName>
            <fullName evidence="3">DUF302 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_03907</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="5190258at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14797">
        <property type="entry name" value="DUF302"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.70">
        <property type="entry name" value="TT1751-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005180">
        <property type="entry name" value="DUF302"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035923">
        <property type="entry name" value="TT1751-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103247">
        <property type="entry name" value="TT1751-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW85582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="194" mass="21945" checksum="AB9C0BB658D8C48E" modified="2019-01-16" version="1">MSDLIGGNADTNHAKQQFSDGVYTEIFTCQRKTIYSKLDFDLIWQRLVSEVGDPSKSKHPRFTEQITGNDEDNFKRYTDNIRSAVKEHGFMAFTSFNYSWIGVFPPHTELRMKKIIIGNPILAYAVLQHNRSATLCIPLEILLDERPECDGGGCQLTWNLPSSGMCGTDSNKDLLRAAKVIDEKLEALLKQVSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SH48</accession>
    <name>A0A3D8SH48_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WSC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_03975</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002889">
        <property type="entry name" value="WSC_carb-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01822">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51212">
        <property type="entry name" value="WSC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="1116"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="domain" description="WSC" evidence="2">
        <location>
            <begin position="2920"/>
            <end position="3036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="277"/>
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    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1001"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1421"/>
            <end position="1457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1644"/>
            <end position="1663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1674"/>
            <end position="1800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1948"/>
            <end position="2073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2202"/>
            <end position="2222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2389"/>
            <end position="2425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2553"/>
            <end position="2572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2705"/>
            <end position="2747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2870"/>
            <end position="2892"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3095"/>
            <end position="3148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
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        <location>
            <begin position="1001"/>
            <end position="1011"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
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            <begin position="2415"/>
            <end position="2425"/>
        </location>
    </feature>
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        <location>
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            <end position="2572"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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            <end position="3122"/>
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    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3131"/>
            <end position="3148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW85650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="3295" mass="321860" checksum="A82A4AB84B68EF09" modified="2019-01-16" version="1">MASSSFTRGTMQGLSSGVEQSGSAVSSSPTFETATSTSVAISSTIASGYSGRSDFQSIPSTASVVETSSPTYTTVISGGSFGSFLSTSYGTSAPMVTSAFGSFSTQMTTSEVGTATGAATVVLGTSSNGIVSSPIIETSSSAAATPGSSSIVTLVFSSSTGATISPSASSSGYSTIASSGVSSVMTPSVSWTSFSSGSIQSYPSSAEPVSSLVSTPGAPSSSFTFVGGLLLSTSTNEHSSSYSSSVESVSITTSASGSLPPSSITTRDMSTLTSSSGPFQSFSNGAGSISTSISTSVLTIQEPSVTSSLNGIPTSSGVSSLGVYQYNSITTSLSVPASSLLSSSTSIAGVSSGGSAFGNSPSTPGSSSSYLTSSTSPSISTFGPEPSLSSSVMYFSAASSASSFSSALLSTSASIAFTVSGGTQSATFASLVSSPAPELGSTSGSSYSIISLSDASLSIGASAKLPTLAMTGSFTALSPSIESRSSTLSSILLASLTPVISVTGSTSIPTAGTSTMTAISLPSSSPSLTIIPSAGGSATAQSPAATSSSLTTPATSGSSIISLSTSTYGASLPGSSVAATSPNAFSSGSTTLAIYPSSSDPGVPSYSSSTSVASSSGFGYEITVSGTTVTVAPSTSGSGVLGSSYSIPAVASGPSSPGSTIAASSSTSSAEVSSYSYLISGTSPSYSGSGTANPLSTVSISPAISSSGLESYSSSTSGVSSSLLASGMSYSSSTAGFTSSSDAGATNYGSTAAISSSASGAGTTGYASSIATTLSSISNYGTPNSGSPTTVVSSGLYTTGLLGASASAQSLASSLIVTGATTYSSSTAVLLPSASSSGDIAYSSSIPTLSPSFSNSGTLGYGLSTPGVSQSPTTWGSASYSSSTANVLPSGSSPGNTGYSLSMSIASPAISSSGVLGYSSSIPGITPSLSTSEATSYSSPTAIFSPSPSSSGIFSHSSSAFGGSSMLPYTSTMASGLGTTGGIGSTASFLSDSQNPMVIMSSTSSSASKPSGQLSNTEANSTYGPTSSLQITTIQTETTSTSSPNTVASSTYGPIPSLSTTPSQTTLSASMLQSLTSLYSSTTGLTSITSPPTLTNPITTSSFVSASTVISVPSYRYLYYGSYADKNYASQGVLDPSQDVANVQPYPPNLATQAISNNSVQGCLDICQRYGVGGAVAIINVQYCYCGTANLMDPASSPSCQTCPGDATECCGGISGSDSNWLVYINSQLVSSLATSLLSSTGTIWNSISGSVPFSSSSIFSTSATTTGYSASASQSFSSSSSGSSTSASSAYTAVISSSTVTSNTIAASSSVSTSVFAASSIASMSTISSTNTIPSTSTIPSSTFASPSGSSMSSTSTTFSTPAFASPTAMSTSSLLNNPSQSSTYEFTSRAISQTTLSMSPRASSSATYTTYMSAILSSPQTESSTKFNPPSPGTSSVTSSSSSEIPSLSSRLGSTPSSVFGATSLSPSSTIGSSLLPLSSTTMSVPPLFTQPSSSSILSTSSGLGIASSSASNTTSQIPSSSAGLSGLSPNSILTSISPSFTQVSSSGLLGTSSGLGYISSSDFGVAFQSPSSSIASTAFSASSSASGTTSQDLSSSIASAVLSSSSSTLGTTSQSPSTSFGSKALSPSSSIGATVLSPSPSTSAISTTYQSPSQSPSSSIGLTVLSKSSSTFDTISQSPSSSTGSTLLSPNSGTSGTKSQSPSSSIGATVQSQSSSASGITSQSLSSSPGSTVQSSSSSASGTASQAPSNSVESSALPSSSNTIGTASQSPSNSISGITSQSLSSSTGSTALSPSSSILGTVSQSPSSFIGSAVLSSSSSTIGTTSQSFSTSTGVTVLSSSSISTIASSSFTQTPSPSILLTNYGSEIASRSSLATTSQIPGSSAGPSGLPPSSSISGTLYQSISTVGSTILSPSSITSGPTSQSPSSSVGSTVLSPSISTFGTTYQSPSLSPDSSTGSTVLSSGSSAFGTISQSSSRSIGSNVLSSSSSMFGTTSQSSSSLVGSGGLPSSSSVGSEVLSSSSSGLPITTQSLSTSTGSTVPSPSTSAIGTTYQSPSQSPSSSAFGTTSQSLSSSIGSPVLSPSSSTYDTTFQSPSSSIVSTVLSSSSGISGIISQSPSSSAGSTVLSSSITSASMSAVFTQFSSSSIPSTSSGLGITSSDTFGTTSQSSSSSTGPSGLSPSIIISGTTFQSLNSAPRLTGLSSSSQSNTNPQSSSGLSIPTVVSSSNAYGLTSASSAVPITSSLSSSSTVATTTQLSSSSAFTGALPSSPSVTSVQSASSFMSLPISTGGSVMASGTSSGTSVTIVSGYSSSSWLDVVTVSSASSAVASTGGYSFQTSTFLPTTNTITSGSSSIPISIGSSSSSQAGSLTSATNSASSTQVTTLSSSGATSSLGQVGTPTSGTGSATSSSNIVPQSSSTQAGLTTTTGIDFSTAALTSPYTSSSLASSFSSGPSTTVVTSSSSSSLATSSSVSTYTVLSTTVAGSIISSITLASTITTALTSPTSTTITIYSSNSMAASSIMTTTVYSSSIIGTSTSTSFIGTSVSGPSTIGQGSTAPSSPTNPTSTAGTLSVFTPSLASTIASSSSSALSSTGTTAITIPGSSISGALSTDFKSTGFSTSPQSSSSLLTSTYGIGGSTPSSAVSNTAVLSGTVAVSSTGTMLSSSSTGAITPLSPLLSLTTSGYSSTYSTLVFTNYVNPSSPSSGASMPSPSFSSSGTITPSSSLSGASTTRSSTSGPTGYTSTSASFDLTGITTSVSSLVTSMLPSSTIVPRAYTSSSSSLITTGSTGSSSPLGIPAFSSSTNALGGSTIASSSLLFSTSTRSSTGWVTSLTVSSLSAFATTSGQTTSAVTGTSSTVFSTAFSSGSGSRMTSSSTGPPSSIVTSTSTSTNNSLIVSVSTRSTSISPTPFPGMKGYYYYGCWAGNAGGHNPGANLDDSIQPPLGPQGQAYPQPNMTAEKCIDECIYYNRTFATLSEDYCYCANGFVDDFARNSCTYGNYIDGTGICTTTCSGNATEICGGYVNAVSHYTVYVTYDPYNGTGTITSANCTKLPVKGPTTLFSSTSTSLSVNLAGSMISQSTSITLGTTASRSGISSVSSSTSGPTSSRSTGGLSSFTTMTNPSGSGKSVSTTSPPTLSTSSATKKASSTVVTRSPYNPYQTHSPSILGFDYYGCWIDPYASTLPDGCVTNYQPKYNYYDGPPITKNLTLELCIMYCFCGDGFQPGFAGDQYNPDGTVKANSQSDGNCYMPCAGNSSEICGGLTAGANGDASWSTYLKHGYVQLANGSVVPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHM6</accession>
    <name>A0A3D8SHM6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ethanolamine kinase</fullName>
            <ecNumber evidence="3">2.7.1.82</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_04145</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.82" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHM6"/>
    <dbReference type="OrthoDB" id="10267235at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF66">
        <property type="entry name" value="ETHANOLAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="402"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="410"/>
            <end position="421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW85820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="421" mass="47474" checksum="5182678D2DE8036A" modified="2019-01-16" version="1">MGTSLEESSVRFIPLTYNNVESQTSALRLILALRPEWEHGDSKIEFIRFTDGITNTLLKAVNKRKGLSDEEIDNEAVLLRAYGQGTDLIIDRERERQNHELLMQYELAPALLGRFHNGMLYKFIRGSVTSPADLRRESIWRGVARRLAEWHAVVPCIPATREPLQQQIEASADFGISTPTPSKKDPALQAAIDNVAPGKIAPNVWSVMQKWIYALPTGTDAQKSRQAQLQHELTRIIKEFSNRPGLGDNSLVFAHCDLLSGNVIVSPRSGDPAPTVETVNFIDYEYAVPSPAAFDIANHFAEWGGFDCDFSVLPTRSQRNAFLGEYIRSYFTHQKGAVPVDEEGEARRLFEEVDLFRGLPGFYWGIWALIQATISQIDFDYASYAEVRLGEYFAWRAESDGTRASSGKEMPLREERWAQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHP6</accession>
    <name>A0A3D8SHP6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_04016</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHP6"/>
    <dbReference type="OrthoDB" id="206201at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00306">
        <property type="entry name" value="Peptidases_S8_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056002">
        <property type="entry name" value="DUF7580"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24476">
        <property type="entry name" value="DUF7580"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0720">Serine protease</keyword>
    <feature type="domain" description="DUF7580" evidence="8">
        <location>
            <begin position="146"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="7">
        <location>
            <begin position="547"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="113"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="555"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="594"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="5">
        <location>
            <position position="756"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW85691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="857" mass="96508" checksum="FD9657C43E38FDA4" modified="2019-01-16" version="1">MGSVLDFVTSSVEAVAQTFAQITEELHRLESTQEQNVAISTNAAFAQTDLALWAYAWGDCNDGEIPPEVQRDAEYGIEEITRNLKGKGKAQSPSDVVIKSRGAAMGVEHLTEELKPPDDQVAPDNPNAVDSSKSKLDSRDLLTEVVQTSLRLLFDALAQQFACCDANHYARLKLTGFINQTDVKSRMFFDLYLSSRHDWKPCRWLESRCTITGSLERRAEPRCNILKKSEDMNKNLNLLLEGAPKSVDPKSQDAHRTQEMPKGGFQVDHCEIRRSSASPIVSLWELLGQSNHMHVTDGASSSITVKERDTLCLNLALSLLQLSGDEWNRVNWCSDEYTSIYFLFDPDTRTVLDKANPYLSWRLGKGEELDHEDPTLLCDPQLLDFAQVLVEIHEWKRLPANLESKRIESLEEFRLALLQHVHDNIRQPQFILALEACVDIAGRRSRNGSVPGEIQNYIWQRILRRLDANALYPELSKPGSELAPLISSDAGDVDEVYDENISYDEPEDRSTHADDFLTRMRQFTDAHIKSLKCLVGTSIPKQNQLDRKIRIAVIDSGVRKDDSRICGWRTGGSIKDCRNFSSPHPEDWNDEIGHGTMVSCLLLDIAPEAELYIAKVSAQNTVPRNKLYCIAKAINWAVQRWQVDIITISLVLSDANHHIDEELQNALNPSFNHTSAKIVFAAAGNKGGNAKRAWPARRSGVIAVHTTDGYGIAANHNPESDAGRVNIATLGRNIRMPWLHDADSDEWKDRFISGTSFATPIAAGIAANVLEFARYKLRLTDRQKHLLFSHHGMRKVLTAMSARNDRDYHYIQPWTLWEMAEKGEWGNWGGRTDVKLFPNSPRNICKVLEFIIGESSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHX6</accession>
    <name>A0A3D8SHX6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 10">Autophagy-related protein 13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_04089</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Interacts with ATG1 to form the ATG1-ATG13 kinase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ATG13 family. Fungi subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHX6"/>
    <dbReference type="OrthoDB" id="70161at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990316">
        <property type="term" value="C:Atg1/ULK1 kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034497">
        <property type="term" value="P:protein localization to phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.900.10:FF:000010">
        <property type="entry name" value="Autophagy-related protein 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1900">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040182">
        <property type="entry name" value="ATG13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018731">
        <property type="entry name" value="Atg13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13430:SF4">
        <property type="entry name" value="AUTOPHAGY-RELATED PROTEIN 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10033">
        <property type="entry name" value="ATG13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0072">Autophagy</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Autophagy-related protein 13 N-terminal" evidence="12">
        <location>
            <begin position="71"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="337"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="438"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="488"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="625"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="699"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="797"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="337"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="546"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="630"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="705"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="797"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="817"/>
            <end position="833"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="915"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW85764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="954" mass="102519" checksum="A9C239FFA8FA67BE" modified="2019-01-16" version="1">MHQHPRMVTASPASLPQTNPMRTNNSREESISSHARSASDMPGYNETDDAGGAVATSGPSQESVRKMDQIVQNFHTKAAVVILQSRISLPVVFTKDGPKKVNKWFQIETDDTNAFRQELQSWKTCNSIDNRPPPLIIETYLNTADFTKNQSLVILDDQGKRWDVQEALNRSGGFNEGGPQPTKINTEVILERWKIELKDVLGDNAYDFGSTLPTVYKKCIVFFRSLYTTAKFVPGWRFVKNLAKNRSANSQLRVNCRILTGEAPPSRYDALTVPLYESSSPVITQYLVGTTDTPVGQFSAEVSYRNDCNFRVDDSEALLSSRFMGADEHFFQPSLATKGSIQRSNSKTEVGSLPAHRHRSDDAEPGQAYGSLSTFHGAAPPLGSSPISALRAAKNMGSDDGSSPADSVPRTRPMQTSRASLRSLEGLNMARRPSLSFQPFKAGSLSSSPGRGNPLLHGVDIPQSPQSLPRTSGISALAQARNRSSLTAGMPASLRGGPVVPENVVPSTSSSPKPTPLSRYSSSFTHRRGRSSFGGTSKFADDDQNSSGKQSFSSASAQPGSGILADTGAGGSSGSLQTDDDNISEFLKLLDSKKTLQSFEHSGETSTKRTSAQLSKFQMMRESNNALTESMSSSTALHRSSSSSSRQLSSVPPMVAATSMSVSSSPGKPISPHTPHTPAIPSRLSANSIAEYSQTYAHTRTLSHRNRDPEPRLEDVADDDSTNELGTNAIDIPTSPRPYYQHTRRSSSVAQRHRAAVVDDDLGDVPFGPHRSISLGADDREPPSLSALLGIGQTSENIASVSSPSPSRLLQPAPHISRSSIPMSHQASSSLEGQESDMPQVPRGLSVGSTNSPYRARLGRIGGRGVTPPQTGSFSSLMDRGSGSGTSERGAGRQSFGRTVGAYEADDEPLLFDMSDMHQSRRSIEEARGGGNLGDNPRGGDSGSSSRRGSRRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SJD4</accession>
    <name>A0A3D8SJD4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cloroperoxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_04213</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SJD4"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF1">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 10" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017705202" evidence="8">
        <location>
            <begin position="20"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="72"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW85888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="428" mass="46118" checksum="6AE21A7864CC8FC1" modified="2019-01-16" version="1">MRTSTTLSLLAFFAINTFAFPSRMFDLSFSAEEKRALDAISAKIESNIKEKRVSTPLAPTFVASEQYVSNTGAHAFVAPGPSDLRGPCPGLNAMANHNYIPHNGVATIAQFVQGTYDVFGMGLDLGAFLAVFGAVFDGDLTSWSIGGPPSASLLSSIGLLGTPQGISGSHNKYESDVSPTRPDLYEYGNDYKVILDQFNDLYSQPLGPNGYDLTTLTPFRAKRFQQSIDNNPYFFNGPFTGVLVQPAAYTFIYRFMSNKSAEFPEGYLNGDVLKSFFSITGTPGTFSWTEGHEKIPNNWYKRALGDEYTIPYFQTDLTAAALAYPQFLSVGGNTGTTNSYAGVDITMLTGGVYNTATLAKGNNAMCFAFQFAQQAAPDLLKGLFSSVTQPLAKINGAFASVFSQLSCPQLQSIDASQFSKFPGSKGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SLW2</accession>
    <name>A0A3D8SLW2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-actinin-like protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_03001</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alpha-actinin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SLW2"/>
    <dbReference type="OrthoDB" id="10017054at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21215">
        <property type="entry name" value="CH_SpAIN1-like_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21291">
        <property type="entry name" value="CH_SpAIN1-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000138">
        <property type="entry name" value="Alpha-actinin, sarcomeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000097">
        <property type="entry name" value="Alpha-actinin, sarcomeric (F-actin cross linking protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.58.60:FF:000279">
        <property type="entry name" value="Calponin domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000223">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000030">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000077">
        <property type="entry name" value="Related to alpha-actinin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001589">
        <property type="entry name" value="Actinin_actin-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014837">
        <property type="entry name" value="EF-hand_Ca_insen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11915">
        <property type="entry name" value="SPECTRIN/FILAMIN RELATED CYTOSKELETAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08726">
        <property type="entry name" value="EFhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00033">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01184">
        <property type="entry name" value="efhand_Ca_insen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46966">
        <property type="entry name" value="Spectrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00019">
        <property type="entry name" value="ACTININ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00020">
        <property type="entry name" value="ACTININ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="134"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="Calponin-homology (CH)" evidence="6">
        <location>
            <begin position="248"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="608"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="753"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="754"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW87307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="783" mass="89035" checksum="391DDA86E2DA2F2E" modified="2019-01-16" version="1">MAPIFGHTGRESIGSCDSDQIQAFPDWDVNKADSLPPTSSPAPEEDLSNEQTHHSSSSPLRIRSRRDRNSQQKSARQQRSATTSLLLTKHAEAQPKFHRSSTSLSPAEALAATEPPHERFKTKMAYEDQQKWITVQQKTFTKWLNTKIEPRELVVVDLVKDLSDGVILIHLLECLSDVSLGRYAAKPKLRVQRFENANLSLDFIRSRGIQMTNIGAEDVVDGNRKIILGLIWTLILRFTISDINEEGMTAKEGLLLWCQRKTACYDEVDVRNFSDSWNDGLAFCALLDIHRPDLIDYDALDKSDHRGNMQLAFEIASKEIGIPALLDVEDVCDVAKPDERSLMTYIAYWFHAFSQMEKVENAGRRVEKFVNNMQGAWEMQNAFERRMQELLKNIREQGVKWQESKFEGTYVDAKAQSTEFSAYKRGKKREWVAEKSDLAALLGNIKTKLSTYRLKPYEPPSELSLAVMETEWAALMKAEMARGQIINETIRDIKNALRKSFADKANDFALTLNTMQLAISGLEGDVEDQLSHVKRLNESLVPMNAYLEKIAIIDQKCEEANIEENDFTTYTYDELCYELSLVKSSVSKKLAFLENQVVARNMTNLTPIQLEEFESVFRHFDRDVTNSLMELEFSAALASLGLVFSEDEMHEYFLETSNGKDHVTFEQFIRFMVDVTEDQNTAEQVFQSFREVADGKPYVTEMDLRHSLVPDEVIEQLKKIVPEHKGPDLQEDRGMVQFDYIAFMDKLISDPEDTSSSSALSEISNGRSTGRGATSPTKVNGVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMH7</accession>
    <name>A0A3D8SMH7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Domain of unknown function at the cortex 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_03085</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SMH7"/>
    <dbReference type="OrthoDB" id="2119945at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013897">
        <property type="entry name" value="Duc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34826">
        <property type="entry name" value="UPF0590 PROTEIN C409.17C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34826:SF2">
        <property type="entry name" value="UPF0590 PROTEIN C409.17C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08588">
        <property type="entry name" value="Duc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Domain of unknown function at the cortex 1" evidence="2">
        <location>
            <begin position="7"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW87391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="314" mass="35142" checksum="2D399C7C27FB8AEF" modified="2019-01-16" version="1">MAHNYILQVTTGSEYDIKKHHIVPVNSPKAVSIDTEHISVDVNVRIQNYRGLPQNSPSTSPYFSIPSHAKNGDQYSIAFRFTPKTTINANDLVFGNDFDHPIRDRLPPGFSTAFKIVKWVVDPGLDGDVYADQPYLYGPAASSMNILNVGAEEAEVEADAGLVFEEGGDEKGLEARKDNNIPASESARKKHFLNEEKRKDWSFEAGTSYGCDFYNPYLDFNDFALRLPGFTLPIMKYWDGQGLRYVLKNRKTNTVLFVVLFTLYLKEDVDEHGNVKEGVEGGVPFKGIAKGYEDDKDEVDAQKPVQATDDDDVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMK6</accession>
    <name>A0A3D8SMK6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA polymerase II transcription factor B subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">RNA polymerase II transcription factor B 38 kDa subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">RNA polymerase II transcription factor B p38 subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_03108</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SMK6"/>
    <dbReference type="OrthoDB" id="5963at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061575">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16573">
        <property type="entry name" value="RING-HC_TFB3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000037">
        <property type="entry name" value="Cdk-activating kinase assembly factor MAT1, centre"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004575">
        <property type="entry name" value="MAT1/Tfb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015877">
        <property type="entry name" value="MAT1_centre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00570">
        <property type="entry name" value="cdk7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683:SF13">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06391">
        <property type="entry name" value="MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17121">
        <property type="entry name" value="zf-C3HC4_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="27"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="167"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW87414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="375" mass="42201" checksum="880C7B4AFE2DFB6B" modified="2019-01-16" version="1">MPPRSRLGAGETGTSALSANNPSDDICPVCKSNRYLNPNLEFLINPECYHKMCSTCVDRIFTSGPASCPVPYCGKTLRKKGFHKAFFADLTVEREVDIRKRVGAIFNRRQDEFETLLDWNNYLEEVESLIFDLVEGTRDEKVKAEEKLKVYKEGNRGEIEENRKAGLEEADIARRREKAEKEAARQRRLAAYREEEEEKADAQRTKRDVLDRLATSNEDANKIAQHAQRVILKKTSARRNLTDAQANSNGSILDSGLTINVRGLKKKEAPIMEKPYDPFGGVDLTPSHYTLQKDYDNEWLGNAKNDIRHMAGGYSIEEYYARTMFEAFSGLGVFIEDEKVPEKPVASSTIGTAAAVQAAGGTVNLEDKMELDDVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SN83</accession>
    <name>A0A3D8SN83_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_03471</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SN83"/>
    <dbReference type="OrthoDB" id="3364132at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR EAF N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="2">
        <location>
            <begin position="6"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW87777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="312" mass="34437" checksum="E43EC282B12D0EC5" modified="2019-01-16" version="1">MKSGQVQVTLLVADKEAKEHQIQDDFKNNVPRLTSYVESAENLPFGIAIFVQGRLDCEALKFNVSVDGTFAAAAIVPRSHDPEVGTKKYVDGFRKIRGHSVTITKFKFTKIHLAIDEKTCAGYNGSGVPDPNKLGSVLITVYRVSLEKLSLGPTDNDQLELGVGKLDEEMLKGRGISHLTSLGPEETFQSRGAWRTKCDDSQGRPFLVFKFKYRSHEEIKNLGIFNDAANSATPSVRPADTDNSEQIRGWLIAQLPGAVKSMLSTQAHTEDTTDIERGNSIYIGKGKEKEQVARGRSENNVKPDIIDLTQED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SN89</accession>
    <name>A0A3D8SN89_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_03335</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Carbohydrate metabolism; D-xylose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SN89"/>
    <dbReference type="OrthoDB" id="416253at2759"/>
    <dbReference type="UniPathway" id="UPA00810"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032866">
        <property type="term" value="F:D-xylose reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042843">
        <property type="term" value="P:D-xylose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd19115">
        <property type="entry name" value="AKR_AKR2D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000007">
        <property type="entry name" value="NAD(P)H-dependent D-xylose reductase xyl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044487">
        <property type="entry name" value="AKR2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018170">
        <property type="entry name" value="Aldo/ket_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11732">
        <property type="entry name" value="ALDO/KETO REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000097">
        <property type="entry name" value="AKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00798">
        <property type="entry name" value="ALDOKETO_REDUCTASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00062">
        <property type="entry name" value="ALDOKETO_REDUCTASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00063">
        <property type="entry name" value="ALDOKETO_REDUCTASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0859">Xylose metabolism</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="10">
        <location>
            <begin position="18"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="50"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Lowers pKa of active site Tyr" evidence="9">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000097-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW87641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="321" mass="36291" checksum="FAAE2011EF5CA563" modified="2019-01-16" version="1">MASPTIKLNNGYEMPQVGFGLWKVDNTTCADTVYNAILTGYRLFDGACDYGNEMEAGQGVARAIKEGIVKREDLFLVSKLWNSFHDKEQVEPICKKQLEDWGIDYFDLFIVHFPVALKYVDPQVRYPPGWQYDGKDDVQLSNATIQETWQAMESLVEKKMAKSIGISNFQGALILDLLRYAKVRPATLQIEHHPYLVQPTLLQLAKAEGIAVTAYSSFGPQSFIELGWDKAKETPVLFEHPVITTISKKYTKTSAQVLLRWATQRGLAVIPKSNNQTRLEQNLNVTDFDLDPSELDAISGLDRHLRFNNPTDYLGTLHIFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SNP8</accession>
    <name>A0A3D8SNP8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Prolyl 4-hydroxylase alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_03624</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SNP8"/>
    <dbReference type="OrthoDB" id="420380at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF242">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="7">
        <location>
            <begin position="53"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW87930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="264" mass="29696" checksum="05D5F1EA02A80361" modified="2019-01-16" version="1">MAYLSSFWIPRAIFPALAIVLGILHTIYPFSHRGLEPRDVGFNMPVRILSHDPLVVHLKSFISREETAYLVSLADPLFKPSGIVDKQGFKKQSENRTSSTAYLPADDPVVQRIAARAAEFQGLRSYNRADLQLTRYHRGQQYKPHVDWYDQFESIINNGNRITTFFVILEASCTQCGTRFPNLRLDCDGKDPGLNETIDCGDVEGLTVRPIPGAATFWRNLHADGLGDRRTLHAGLPPEDGVKIGLNIWTSVKTDIFGRMQPEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SNQ7</accession>
    <name>A0A3D8SNQ7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_03620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SNQ7"/>
    <dbReference type="OrthoDB" id="3266505at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF17">
        <property type="entry name" value="SCFA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="2">
        <location>
            <begin position="212"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW87926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="641" mass="71102" checksum="EF43CC5FCF332969" modified="2019-01-16" version="1">MSLVDGAFQLHSSATPKTLFTDALPGGHRKGTPPLRIDQHAEHAPENVAHDQARRAIPGRRHLSTNASSHMARSLATDLISLLPAKDVAELLVNTYFDRVHWFILIFHQDSFRQSWPEIYDSAPEKDGGYYQNPGFISTFLMVMAIGSQYSSPHTQHLLSQLGVSQEDLQEKILLLIKAKLLDIASLGSLEAVQTCVLLGTYYLYHGRPELAWPVCGCGLRVAQAMSLYRKLPLARHDTVPISLELRRDYDARKRCWWAVYEIETFCSMSYGYPLSIQDSDCDIDLLEVASSFAISDTVDGSLTTKVTLRSYKHFMSKLSMIIKATLVQLYGISQDTMSNLSQTPDSSASLRRLIRNATALDSRLQSWRKDLPNLLRLNSSGSSPAIATATIDIGEGTSTPSAQSEDYIYQLQALTLEFTYQNARILIHRPLLSYKMARKGFDSSESHFLRNNNKPIDPFSNSLRICQEAALATAEIGSLPIFLLSTSTYASTFFGIHTFTAGITLCILSSVEPLTLDSQKSKIGLRKLMAMQTRLKSVSKVSVQGAEILQRLARLVVEKELNELLDASPSLDTPVNNRAVDDEPQEHQRAIMVTEAQTAAMGPYPTVDHVTEDTMNDGFGMDVVENSAMSQALVDLDQGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SPT8</accession>
    <name>A0A3D8SPT8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 64 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03512</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SPT8"/>
    <dbReference type="OrthoDB" id="10058186at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09220">
        <property type="entry name" value="GH64-GluB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.50">
        <property type="entry name" value="Beta-1,3-glucanase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.110.10">
        <property type="entry name" value="Thaumatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032477">
        <property type="entry name" value="Glyco_hydro_64"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037398">
        <property type="entry name" value="Glyco_hydro_64_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042517">
        <property type="entry name" value="Glyco_hydro_64_N_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037176">
        <property type="entry name" value="Osmotin/thaumatin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38165">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38165:SF1">
        <property type="entry name" value="GLUCANASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16483">
        <property type="entry name" value="Glyco_hydro_64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52006">
        <property type="entry name" value="GH64"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GH64" evidence="1">
        <location>
            <begin position="3"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS52006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW87818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="369" mass="39608" checksum="3B4BB2876FE3D63D" modified="2019-01-16" version="1">MTPPTLDIHIQNKTSSSNVSAYITGQALNHNNHVVLVKADGKSLYYPESPSEILQPLREDCAIPLGKPGSTTTVTIPQIAGGRIWFSVDSQLTFLLNPGPAVVEPSVSNPTDPSINAKWGFCEFTYNSSQLYANISYVDFVSLPIAMGLIPGAGPEQVVQGLKEDGLELICAGLVAQGGDWEKLIFKADGKNLRVLSPNNAIVMNQGNLFRGYYDAYVNEAWSKYAKCPLTVDTQAEWGKIEGQVHGDELKFDKVGASFGKPSTGDIFGCSSGPFANNAGAAGPLTARISAALNRSTLLVNDSHPHKEKVENYYQHQVTNHYARLVHEANKDGRGYAFPYDDVAPGGGGIDQSGFVSDGNPKTFTVIVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SX79</accession>
    <name>A0A3D8SX79_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02088</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW90923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SX79"/>
    <dbReference type="OrthoDB" id="2148716at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13577">
        <property type="entry name" value="SnoaL_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="15"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW90923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="166" mass="18160" checksum="20A0FAB3B8592619" modified="2019-01-16" version="1">MESPFSLPAVLHPALTGRDAVVDALYRCVMAFDTNDAALFDSSFMQDGVFDVNGRAMEGLPEIHSTGLALIFRVDTTHMATNVRVHMRTATEEHEASLTATVLSQHFAKGKGMEPGQASLMGGSLYRAELARDTDGLWKFKHLLIKSTWAEGDWSVVGGKFNEAEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SY35</accession>
    <name>A0A3D8SY35_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA/RNA-binding protein Alba-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_02390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SY35"/>
    <dbReference type="OrthoDB" id="424402at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="entry name" value="Alba-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002775">
        <property type="entry name" value="DNA/RNA-bd_Alba-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01918">
        <property type="entry name" value="Alba"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA/RNA-binding protein Alba-like" evidence="2">
        <location>
            <begin position="95"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="170"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="60"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="185"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW91225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="253" mass="27649" checksum="21182D58088745DC" modified="2019-01-16" version="1">MAGIEQDVENRAKNSLYEKQKDQDSMTGNQKRPAQGESASMGGPTILARKKQKTSNSLITTSADSTPAASAAKSNEPAPSISIPSAVSSTHEVTTMSIGSNAHIQQKVTRILDLLCKETEPSAQQKAVMLYAKGPTVSKMISIIEIVKREIGQVGQWYQYNLVESKLSVQPKRQENQDGQSAEDQQMDEGASEDEEKGSAAFEKMKTPFERAIEGQDKVRAVPTMRIFVSRTRIESLKKSSGEQSNTPVKNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SY79</accession>
    <name>A0A3D8SY79_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ferric-chelate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_02296</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ferric reductase (FRE) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SY79"/>
    <dbReference type="OrthoDB" id="167398at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000293">
        <property type="term" value="F:ferric-chelate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015677">
        <property type="term" value="P:copper ion import"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06186">
        <property type="entry name" value="NOX_Duox_like_FAD_NADP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013112">
        <property type="entry name" value="FAD-bd_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013130">
        <property type="entry name" value="Fe3_Rdtase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013121">
        <property type="entry name" value="Fe_red_NAD-bd_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051410">
        <property type="entry name" value="Ferric/Cupric_Reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361">
        <property type="entry name" value="FERRIC/CUPRIC REDUCTASE TRANSMEMBRANE COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32361:SF3">
        <property type="entry name" value="REDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G13750)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08022">
        <property type="entry name" value="FAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01794">
        <property type="entry name" value="Ferric_reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08030">
        <property type="entry name" value="NAD_binding_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00052">
        <property type="entry name" value="Ferric_Reductase_Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01168">
        <property type="entry name" value="Ferric_reductase_subgroup_(FRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="295"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="12">
        <location>
            <begin position="320"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="552"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW91131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="671" mass="73857" checksum="A8BBE2EED9474E4B" modified="2019-01-16" version="1">MASLHLRHIANAADSNSTIVGHWGYVDRILPCTNDAGSCAYLDAVYWMHDISMLYTFIMWAVIGGFFVIAVALRFMKPTATRKSIAGSEAQKMGVSNASYRAWRASLAGLRKVLLPESLTAFFGNVTRLQLLILAIVLAYLLVFSLVGIVYKTWITPVKAHPGMFNTRTGLGGFSDRVGALAYALTPLTIALASRESILSLATGIPYQSFNFLHRWLGRVIFVQSFIHTLGWTLIEGNFYKPQPITYTAFIKEKYIVWGIVAMTLITFLYIFSLRSVIKRTGYEFFRKTHYVVAAVYLGACWAHWSHLACWMIAALGIWGIDRGLRLLRTLLIHVGYVDGSKGFGFHAAQASIKYFDDVDGGVIRLEYTHNHEAWEVGQHFFLCFPALSVWQSHPLTVASVPGQHPESPRHVYIIRCRSGETGRLKRLYLELASQPNADSKNGALTTPVVMSGPYGSSLLPRSGDSQLPEPTNILTVAGGTGITLTLPLVQLATSSPALLQGAAVDLVWTIRRVSNVDWIAQELEGLRKRAASSASNLRIHIFITQESSASSSATPSVSSLTEKIQPDTHTQPLPSSSSISSMETNSQALQSSKNFSVTYLTNARPSIEEIVRTFVETRAEPAFRTRVVASGPNEMGKDLRAAVAGLCDAGKVWKGDGTRDLELVWDDRMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYV0</accession>
    <name>A0A3D8SYV0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial resolvase Ydc2 catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02625</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYV0"/>
    <dbReference type="OrthoDB" id="5552842at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000402">
        <property type="term" value="F:crossed form four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070336">
        <property type="term" value="F:flap-structured DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000403">
        <property type="term" value="F:Y-form DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16963">
        <property type="entry name" value="CCE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039197">
        <property type="entry name" value="Mrs1/Cce1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015242">
        <property type="entry name" value="Ydc2_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28072">
        <property type="entry name" value="CRUCIFORM CUTTING ENDONUCLEASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28072:SF1">
        <property type="entry name" value="CRUCIFORM CUTTING ENDONUCLEASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09159">
        <property type="entry name" value="Ydc2-catalyt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mitochondrial resolvase Ydc2 catalytic" evidence="1">
        <location>
            <begin position="52"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="355" mass="39485" checksum="476EB5815CE829C7" modified="2019-01-16" version="1">MAAKAAPTLKLAQLRSVALRCGIARSGTKPVIHQRILDEAVPAFEQNEAVRVLSIDMGIRNLAYCMLEVPSKSKTKPSKAAQPTSEKLKIIAWRVQNVIPTPTREPQADQPLKGASKLAATLVGKKSGDEVEKPVGNGIEMVSEKESFSPAKLSALAYTFIRHEIMPLSPTHILIERQRFRSGSLPHVLEWTIRVNMLESMLYSVLCTFKAEGIWKGEVTPVAPGKVFPYWFPDDQGVPQEASLLTKGRKTANLNKLNKGRKIDLVRNWLEDERSIILASDDAKETAKAYIGKWDRGNGLGKKRPAKVEKEETEKLVKLDDLADSLLQGVAWVHWQENKRITAQRGISALIEDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZY9</accession>
    <name>A0A3D8SZY9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative sugar transporter-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_01260</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZY9"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF26">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017682282" evidence="10">
        <location>
            <begin position="22"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="409"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="439"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="11">
        <location>
            <begin position="16"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="501"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="508"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW91866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="539" mass="59857" checksum="9EF4611F97C5F330" modified="2019-01-16" version="1">MAPYFGMTGGWLTFWVTVACATDMTLFGYDQGVFGGVIVTPDFLDTLGLNNNTGMVGTVTAVYDLGCFAGAILAVVIGDALGRKKSILLGTAIMTVGAFMQIFAFTVPVMMAGRIIAGLGNGINTSTAPVWQSETSKASWRGKLVVIEMILNIAGFSLSNWMTYGFSYVSGPISWRFPLAFQLIFIIILFATVPWLPESPRWLAAKDRIPEARQILADVEGLPVSDQRIENDMKDICYAVQYERDHGVSWGDLLRGRTGDQAGTSTIRRLVLGMGTQIMQQLSGVNVTSYYLPTVLISSVGLTNSLARLLAACNSVSYLFFSLIAIPNVEKWGRRNLMMYAAAGQAFCYLFITVLIRYSELPGYAYQKEVASASVAFFFLYYVFFGIGWQGVPWLYPTEINSLSMRTKGAALGTASNWIFNFMVVEITPIGIESLQWRFYIIWTVFNAMFVPIVYLFYPETSDRTLEDIDRLFRENGSVFVFKDKDAIAAKRPERYFEMEEGWGSGRESGDTDALRLKKTKDEEFGGNSGVMVDHQEGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0H7</accession>
    <name>A0A3D8T0H7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_01469</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0H7"/>
    <dbReference type="OrthoDB" id="4225201at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017683205" evidence="2">
        <location>
            <begin position="17"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="284"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="659"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="779"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="435"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="523"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="605"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="779"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="809"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW92075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="832" mass="91424" checksum="D77859F82BE19F7F" modified="2019-01-16" version="1">MRGLVTAALVLAPALASSFTIPHDEHHGGKTEVAEDQSSALISLGGKDLKSHDAMNFRLDILPSTEPCGFGNVTIDGQVLPQTEKEGVWSGNGSVPVGGKSIAVASWSFECLNIPNVASVQLMKFKVDAIDGKSLEDVGFTAVFKQAEDSKIIEIVNKPTLPEFPSPAEPHHGQHPHPAEHHPHGGDGPQGHHEVEFHQRFEEDMAELRFMKHQLLELEWMIYEKEQAMFHHHKSHKSHKDSPELGQDIQQCDSLRCLIKAAVDKARGAVNNVVGKFGREDEMDFHGRHEFPHPPRERKHGNHTGGPHGPHKGNHTHPHFPKRPHGLPVCRFPPPPPHGHGPPGPPPPFGHHMRPDFHSSPPGMHRGPHSLEPQHGKHSPPELDPEERRPVEMDGSVRHEDEPQSEHDGAFHHGKPHGKQHGEGIDDLEESQPEQEEHGRPEFHDSEQHEAHPFDGPKSHEGPESDGPPQHERPEGHPPHGGPDFNGPPPHGRPEFDGPHPHQRPEGHPPHGGPDFDGPPPHGRPEFDGPHPHKRPEGRPPHGGPDFDSPSAHGRPEFDGPPPHERPEGHPPHGGPEFDGPPPHGRPEFDGIPPHDGPENEEPHPPPGDDGPGGPPPFDGPHRGPPKPMAKVFHVFKWSVVAFLCTIFLAALHKRTCTPDKRAKRQARREKRELRRAHRREVHKNAIMKLMARIGGNDSESDDFEEKYKHQRLMSDAEDGMSTTMSDEITQLRTAASVVGEIVAASPDSPRPTPSITVSVHDFACSTPSEQAPLFSDDLYSEELPAYEDNDGSEASSIIADGFRYTPGSSEYSPSHSSSGSVSDILGPDTKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0S3</accession>
    <name>A0A3D8T0S3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Maintenance of telomere capping protein 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_01566</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the MTC6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0S3"/>
    <dbReference type="OrthoDB" id="5573651at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051008">
        <property type="entry name" value="Telomere_Capping_Maintenance"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057530">
        <property type="entry name" value="TIM-barrel_MTC6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35518:SF2">
        <property type="entry name" value="MAINTENANCE OF TELOMERE CAPPING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35518">
        <property type="entry name" value="MAINTENANCE OF TELOMOERE CAPPING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25506">
        <property type="entry name" value="TIM-barrel_MTC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="604"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="domain" description="MTC6 partial TIM-barrel" evidence="12">
        <location>
            <begin position="19"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="631"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="631"/>
            <end position="641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF25506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW92172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="651" mass="70335" checksum="BCFF871A76736F65" modified="2019-01-16" version="1">MTEMFTPDDGAVPVPPLTTVFLSQRDLGLTVPINYVTQPGVSFSAACFPFHRYDDDDAGDCLSNLLADGFRRFEIDLYWDEERQIWSFCPVAIPTSIPNAAPSSTVTLSFQPSTASSFRSGSLAASSSTSDSASSTSTSSVSSSITKSAISSAAGLGARQATSTADAGTGISATSLGTTLPTASVLPDSDNNPLVEISPYICTPTINLLTFTSLILDYVKKTETDLGAHLIYVIMNLHAAASDMSPTAPAPSVTKLPTSGNLLSSLWSSNLSAYLYTPDNLRSDRANLNGSWYTVAPRYRPVDGYYRTTRTVNNIFTTEDGWPSEGYIELSRSKRLLLGHGTHDPQLAGYNFTGDQATIFPEGYIQASQSNLVVTSTDAVTSGCFRSNITDDLSRVNASWATLSNGDGTGFTTTSALTPLLNLTSNITDCGISPILNVTLLNATAREDYKPYQRYSYSTIWSWAPNEPKNTSSNTADDLFRCAISRPGLLGRWAVGDCSQKLFASCRALEQPYNWTLTTYQMSYSFASQACQYPYKFAAPRTALENAYLFQAMQASNRDFDGNGAWVDYNNLDVKGCWTMGGQNATCPYSGSTTSANDLKRKTVLVPTIAALIVLIVTVLTVLAKVAGNRKTNRRRNKRAHNGFVYEGVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0U3</accession>
    <name>A0A3D8T0U3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DASH complex subunit ASK1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BP5796_01435</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
            <location evidence="3">Centromere</location>
            <location evidence="3">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the DASH complex ASK1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0U3"/>
    <dbReference type="OrthoDB" id="5573898at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042729">
        <property type="term" value="C:DASH complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044732">
        <property type="term" value="C:mitotic spindle pole body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008608">
        <property type="term" value="P:attachment of spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013964">
        <property type="entry name" value="DASH_Ask1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28200">
        <property type="entry name" value="DASH COMPLEX SUBUNIT ASK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28200:SF1">
        <property type="entry name" value="DASH COMPLEX SUBUNIT ASK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08655">
        <property type="entry name" value="DASH_Ask1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="16" id="KW-0137">Centromere</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="11" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="17" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="13" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="12" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="82"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="112"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="231"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="333"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="390"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="17">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="161"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="18">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="18">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00014520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RDW92041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="412" mass="45903" checksum="252AD8F7A6809DFE" modified="2019-01-16" version="1">MSRSSTSSARSLEELEKLEQQITLTLQEIDQNFNRAHRIVSTSILPIVEQYRDHSNSLWEASKFWKQFFEASANITLCGVEENEQEEEEASYSQSHENTSAYGTSQVDETFQTEGEHQSYEQDSLIDDPDMSGSTPRAPRPRAASGGKPKFAEYPSSYEALKQELKGKNVDDDDTQIAPSTPGPQQRIPDMSMTPTSSPFDPTLYDPTTQPSSRAVADPLLHRVLDKTFRLQATPHTARKESKMPASKPSWRASDSPMSSPPVAAPELRADIFNSPVRQQYGRAPAPRTPGVSVQTPATGKRKFQDMLQSKDLNPPLQQDATTIITSKKDEITWESDSDDDPDEMYRQMGMSPPKTIQFSLPQSRLLQTPAREASKQIVEDLLTTAGAEYDDSDALDSPSMVAMKDDLDDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T144</accession>
    <name>A0A3D8T144_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L30</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_01677</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T144"/>
    <dbReference type="OrthoDB" id="1928736at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000001">
        <property type="entry name" value="60S ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="Ribosomal_eL30-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022991">
        <property type="entry name" value="Ribosomal_eL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002172">
        <property type="entry name" value="PRK01018.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00709">
        <property type="entry name" value="RIBOSOMAL_L30E_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00993">
        <property type="entry name" value="RIBOSOMAL_L30E_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="4">
        <location>
            <begin position="14"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW92283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="110" mass="11760" checksum="19D62531328C75D8" modified="2019-01-16" version="1">MAPTKKAKKTSEGINSRLALVMKSGKVTLGYKSTLKTLRSGKAKLVIIAGNTPPLRKSELEYYSMLSKTNVHHFAGNNIELGTACGKLFRCSTMAILDAGDSDILTGEVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1Q7</accession>
    <name>A0A3D8T1Q7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_01823</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1Q7"/>
    <dbReference type="OrthoDB" id="5244761at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053181">
        <property type="entry name" value="EcdB-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785:SF4">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47785">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="100"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="204"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="424"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="497"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="503"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="544"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW92429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="981" mass="108923" checksum="9538597722443FEC" modified="2019-01-16" version="1">MNNGPEHNNAHADEHPRYVMGRPYEPQSGPGQYRPPPYTPHSQAPLPQTPISGPGQPYENMPGYGHPPPTPRDQYNSLPPQYAPSSAPSTKRKPQRAAQACDSCRNLKAKCDELKPCTNCRDKGLQCNFREPPPKQQDKSQEVLMEAIANLTSQITSQITTLTQQHQKLSDRFDRDMDEMKEWMKANGYKGPKAPNGATQFKEETVEDKHLSQAALPSELDTEPGTGDPDTEPPPEGLPPTDYSEEEDQGDPKPPGPPAIPVNHTTGAAKLLNSGPIAMMTRNAPFPKHIHRRDLFPIIQEERRGLLRLFGKGEGFDLARGYNIDVQVEHTETPSDLHSEASSPAAVEDWGQVGGVTPPGNAENPIQRGELNANGMPDFKRETVIDLVDSYMNHMNIMHPLITEKNKDQLIDYFLKSIADSQPKHRQVAALHQQGSTPESPGSKRKRSRDGSSEYQDPSSHIYRDSSKPGHPPRTISTALVLAMLALGAICKNKDRIRDVSGTPDQDTPSYRSSPQLKNGYPPSPINGSPIMPGQSPEMASPQDVDRLHPHSRRTSMDRSAPHLTSSGVKPRNMDLMPGLHYFAIATDILGNQLAGNTLQHVHVGILLSLYHGQLGRVLESWPYLNAACRSLVFKLRNRLGRWEKLMARDGMQTGQTPARDNGYLFAFWTCLQLESDILAELPVEQSGILKLEAKVPWPNMVLAKADGFSEDVLDNYSAQLFLRKRLNEIHTMFYSPDLDNGPSPRAPLAHTSVAYMAQFLENWRKTGPEKFRWNDGDPPSDNILIARLRAKYYGARVITCRYFVLKILENSYTTSTAAGGKNQKITDEFREGVSVPIINKDATSVEHISTEVLGYVRSCIDALKESTMAFDNVVEDIGKQRLIVTNIWGTAHAQWGNMLTLLAVYQDPILKDMVEREELTTLLKRTIRFLRMAAQPNSALELDIKILVHLGEKFALLRSGGGVGSFTSSHSSGDVVMTGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1V9</accession>
    <name>A0A3D8T1V9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phospholipid-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_01946</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1V9"/>
    <dbReference type="OrthoDB" id="5594612at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000075">
        <property type="entry name" value="Related to IVY1-phospholipid-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037470">
        <property type="entry name" value="IVY1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38407">
        <property type="entry name" value="PROTEIN IVY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38407:SF1">
        <property type="entry name" value="PROTEIN IVY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW92552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="456" mass="48814" checksum="77B1BAA361531B0E" modified="2019-01-16" version="1">MAQSSRAPSPTPSALPPIPSSPTYSYASTAFPTSTYNLPLPPPPRSAHAVLSKSDLEASQAAYSELLSTAKAYRLSLAALSNTASAFGAALENCARLKEARSEALHPQGGSISNSFTSKGNCTADTLLAASGVHQLIANHQQILSECVYRNFEVPLLHELDQWQRHMEEEEMTYQREAKSMSKEIRKMEKEGLKLHRQRTRDVAKFRSHLVDLTTKLDGLTTLHGSHSRGLLREAQDMSLKIVDSGAGLVRAEVDIFEALARKGWSGGGLDDLLEKGRDIFANDGENTPGQHEGSGSKIFSILPQKSILPDSDGNSGTAVRSHGRNNSLGADVDRYQSLAGAVTGADDTGSIFSESGILNRSRGVRPFSPPPLDRRMTKSMDDGQSATTVVKVPTTVQDADETAVAEDVAVGDDEPGPSAIAEVESGTPSIDSTESRGRERRWSVTDDESSGSPGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1X1</accession>
    <name>A0A3D8T1X1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_01959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1X1"/>
    <dbReference type="OrthoDB" id="10282041at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW92565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="356" mass="41454" checksum="1D27CB20968A3CDE" modified="2019-01-16" version="1">MANPYNPIEETEEIVGNLSRDDMTCQLIRYKLSRYYKGFGRKRKVTEFLDGSGEDRFKEVEPEDGDKAAMKYEKMAKQCFKHLNTSQLVLIRKFLILDIFAEAEEVMQNSFTYMSDMRLLVTPSKACTLRALPAEVRSRIYEYSLMRTLDRPCNQALLTALRPDEKLYHEALAVFNKINYYQLGTSTGMRSKRNLHAFKNVMSDNAIRNIQNMMIYLGDWECGPRTTASELEWIHFQQHRNSRLGMASNLRSLIFVVNKVEELYFTSQVLCSLRNLKRITAVEILFTSAMDWDQRYGHEIMPNADDVEVLNRRLGCVAKLKRVYVTTTSRPGDKVKYTTEEWFWRAAEGSALQITQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T752</accession>
    <name>A0A3D8T752_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Glutamate carboxypeptidase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_00139</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M28 family. M28B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T752"/>
    <dbReference type="OrthoDB" id="5841748at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004180">
        <property type="term" value="F:carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08022">
        <property type="entry name" value="M28_PSMA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02121">
        <property type="entry name" value="PA_GCPII_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000101">
        <property type="entry name" value="N-acetylated alpha-linked acidic dipeptidase like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.40">
        <property type="entry name" value="Transferrin receptor-like, dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046450">
        <property type="entry name" value="PA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003137">
        <property type="entry name" value="PA_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039373">
        <property type="entry name" value="Peptidase_M28B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007365">
        <property type="entry name" value="TFR-like_dimer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036757">
        <property type="entry name" value="TFR-like_dimer_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404:SF71">
        <property type="entry name" value="CARBOXYPEPTIDASE TRE2, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10404">
        <property type="entry name" value="N-ACETYLATED-ALPHA-LINKED ACIDIC DIPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02225">
        <property type="entry name" value="PA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04253">
        <property type="entry name" value="TFR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52025">
        <property type="entry name" value="PA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47672">
        <property type="entry name" value="Transferrin receptor-like dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="PA" evidence="4">
        <location>
            <begin position="310"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="6">
        <location>
            <begin position="488"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="Transferrin receptor-like dimerisation" evidence="5">
        <location>
            <begin position="753"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="98"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW94376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="881" mass="98482" checksum="4CCE3872D04B4E96" modified="2019-01-16" version="1">MADEKPNKYEPVANAPIPSYEEATGSSSRTSTPADDRLRTTSEASHPAEREGLLGNDLGGRIPVPTRRQGYRPPPTEDSSSPRQSFEHDAFLGQENGRGSEEAEEVRREMEELEMEEPASQSIWGKRISSLSSRLPFRIRLPRWRSLRMPRIDTNFLIILARIFAIFLVVAVIYVLFVSDIFTNAANRMAGQMFDPESVRVYMQSMVDEERIRTRLEKITQTSHLAGTEGDYVLAEYVQGIFATSGLEGVHMDEYQVYLNYPKEGGRKIEILKDDGSVSWSARIEEDQAYTDRPRQQTPVFHGHSKSGDVTGPLMYANYGSRKDFKRFYDSGIETKGAIALVRYGGTQSDRALKVKAAEEVGFAGCIIYSDPADLKNVKQDEVQRGAVSLMSWVVGDVLTPGWASTKDAKRISKENNPGLVNIPSIPISWGDAQHLLRAIQGYGIIGPEEGGWVGGIPNVVYWSGNMSSPKVHLVNEQDEVEKQKIWNVMGKIEGIEQNEKSIIIGNHRDAWTFGASDPGSGTAVMLEVVHLFGDLVRRGWRPLRTIEFASWDGEEYNLIGSTEFVEDNIERLRKDAFVYMNVDVAVGGQDFVASGSPVFKKALLRVLDRTVDPIRNATLRALWDSRQGELEGLGAGSDYVAFQDIAGTSSIDFGFHGGKYEPRGEFTLDGSNYAYHSVYDNFERMDMIGDPGFQYHKVLAQVWGLLILEFCDRLVLPFDMSAYASSMTKWVMELEDWSGNKGANLPGNTPWSTDPLREAVLQLAQDARLFEKWEAEWDTVVLNSGGFESPVLAAHRKSHNTRMANFETHLLDMEAGGGIPNRTQFKHVVFGPQLWSGYEEAFFPAIRDAVEARDWTLAKKQVDKTADIIMKASKKLVGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7C9</accession>
    <name>A0A3D8T7C9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b-c1 complex subunit 6, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Complex III subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_00219</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UQCRH/QCR6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7C9"/>
    <dbReference type="OrthoDB" id="405848at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.20:FF:000003">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.20">
        <property type="entry name" value="Ubiquinol-cytochrome C reductase hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003422">
        <property type="entry name" value="Cyt_b-c1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023184">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036811">
        <property type="entry name" value="Ubol_cytC_Rdtase_hinge_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15336">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 7.8 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02320">
        <property type="entry name" value="UCR_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81531">
        <property type="entry name" value="Non-heme 11 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome C reductase hinge" evidence="12">
        <location>
            <begin position="74"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="75"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW94456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="143" mass="15464" checksum="253A86ABBAC3FC8B" modified="2019-01-16" version="1">MGFFTDLWESATPWSSAEAEAVSGGTGTDSTPAQGGEAGEGEAADKNASTSDNKDGDDDAEEPEEEEEEEELEDPQEKFQEECKESKQCSGPKHHFDECVERVTGASESEDKKGPSEDCVEEFFHLAHCANECAAPKLWAALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7I9</accession>
    <name>A0A3D8T7I9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Sialidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_00247</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7I9"/>
    <dbReference type="OrthoDB" id="5300765at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="449"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW94484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="565" mass="63325" checksum="CE243AD7A4FDC345" modified="2019-01-16" version="1">MSFDYSFSFGPATPPSFSFEEALPDGAFRATHSRSNSYASLYSQDSSPESVATHLTTPMKSPIRHHGPLLLPKIRPQDQEIHSPAKRFKQTPLSKPLNSAAAFRPSHTRSYTNPESISFIQQDHGFQAHAVPETMSLGSPISMDATLQQRRASSASLDGQTLGKYGFPTYRQMPAYISSTTNSHPESYVPQTFFPTPQRTPSPLLQSTSVDDFVINPFDHGSTTTMMSYLTSPNPAPALVYHINTHYRDPSTKHFWWDIRQIRPWTSFNVDTITTVPGLHGLLNIALPEMTFPVPARTSSKPETEADLQAIYSSFYATKLNAALSLSMGNRHLMMRSASAKQPEPSFISNYTDDNSQLIYGRGLGRVVGLVKSYNRWNTGMRTEGNHKKVEYLRGLSHLHRYMREHGCRYGFIMTEIELVVVRNGGDTTPHFGYLEVQTIQLAAHDDAAPAQAPDPDFPSLNAAFSPQDDPEREPDRPKMTACLALWYLHMLARDDTLPGQVSWKSEIGAPAEGTRRKCLPKDDWIPEPQLAEKREAKRARGWVWPEESVGRKELGKRGVKYGHC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7P4</accession>
    <name>A0A3D8T7P4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_00313</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7P4"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW94550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="128" mass="14385" checksum="B6249D9AEA792C3E" modified="2019-01-16" version="1">MYSALLASSQISQAPRRLTRPPRSDSLQGDFGPLADVQIEVDAVTAVEMNFGIVEPNIRPTRRRSSLTASTIMINLTTRRPVQSNEGSAPLRNPFTSASPTRREHWILLRREDLHQPWHSAGQTRVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T866</accession>
    <name>A0A3D8T866_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_00384</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T866"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="92"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW94621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="340" mass="37824" checksum="022D22FFE0FE36D3" modified="2019-01-16" version="1">MDSKPSTTSDASPMYPRLVSATSKAWYYFIVYTRRVLLKLALSILKRFPGMLYPGVKPTLTKSYPCHPNLTHRFFYPKSYNASDPALPLYIDIHGGGFVFFAAQVDDKFCSNLANNNNILVVSLEYSLAPSSPFPVALHEAADVITSIIDDGSLPFDRSKVAVGGFSAGASLALTVSQLHSIKKILRGVVAFYPVVDWTRDVKDQLASKPKGCGPDSLEARMPLFEFCYIPAGQDMKDPLVSPSFATRDALPSKVCLVGCEHDLLCRDAEVMAQRLAKVEVQDGATAWEHDGVKWEKIVGQVHAFDFLPFPLGEAKKIREKRAKQMYDDVVDWLFREVYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T913</accession>
    <name>A0A3D8T913_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">HotDog ACOT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_00813</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl coenzyme A hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T913"/>
    <dbReference type="OrthoDB" id="331699at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047617">
        <property type="term" value="F:fatty acyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006637">
        <property type="term" value="P:acyl-CoA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03442">
        <property type="entry name" value="BFIT_BACH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000032">
        <property type="entry name" value="Acyl-CoA thioester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.129.10:FF:000038">
        <property type="entry name" value="Acyl-CoA thioester hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033120">
        <property type="entry name" value="HOTDOG_ACOT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655">
        <property type="entry name" value="ACYL-COA THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12655:SF0">
        <property type="entry name" value="ACYL-COENZYME A THIOESTERASE 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51770">
        <property type="entry name" value="HOTDOG_ACOT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="HotDog ACOT-type" evidence="5">
        <location>
            <begin position="94"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="HotDog ACOT-type" evidence="5">
        <location>
            <begin position="291"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW95050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="464" mass="51371" checksum="423C252964A5F7E9" modified="2019-01-16" version="1">MAKRLRAFPRYWPSICKASEAGVSRPRRHFSSSMSCGIDGVYSELTAMRTQIPFIEALKAQSAEKDGKLAVKHVPIQDQIDSSPKTMSQSYHKVVLPLAHDPWLLDSYINSSGHIRLGTIFMDLDAMAGVISFKHSGDNLMNVTAAVDRITLKRPLTAICDLELSGKVTFATGRSSMELSLQVAKAPEEGKTVQDEDILMTCAFTMVSLDPVTKKAVNISPLKIENAEEQRLFDQGKKNYAAKKELAKATLRKNTPNDEESDLIHALWLRQLDYHDPNTPTRKPANAMYMEATKIQSVQIMQPQYRNRSNFNIFGGFLLRTTFELAFTCASAMSHTRPTFVALDPSTFENPVTVGSVLYLTAQVVYTDSPVVDSGDPKASAEGSTRIQIRVDSKIRNVEHGETKPTGVFNYTFEVKKDIKVIPESYSQFIMYLDARRRALNTIQSIESPNVGDGSGGSTAGVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T997</accession>
    <name>A0A3D8T997_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative RRP15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_00860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T997"/>
    <dbReference type="OrthoDB" id="20949at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012459">
        <property type="entry name" value="Rrp15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13245:SF14">
        <property type="entry name" value="RRP15-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07890">
        <property type="entry name" value="Rrp15p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW95097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="274" mass="29991" checksum="E3B29F8A9F936462" modified="2019-01-16" version="1">MAGPNARKRKLDEGKRPKSKPVKKFKKQTDYDNQSSSDEEEEAQEFQAVNLQDSDEEGLDTTDLVHEAEFENDEPALDGVSDTEVTDASNSDSDSEDGSDAETNPNLIRKRKRNDPEAFATSMSKILSSKLSTSKRSDPVLSRSVTAIQASKEITDLALEKKARQKLKEEKKVAFEKGRVKDVLGASTAFDAAHNDGEITATTAEVMETEKKLRKTAQRGVVKLFNAVRAAQVKGEEAAKEARKSVVGQGRREEKINEMTKKGFLDLIAGGGAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9C7</accession>
    <name>A0A3D8T9C7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_00898</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9C7"/>
    <dbReference type="OrthoDB" id="21470at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12323:SF0">
        <property type="entry name" value="CALCIUM HOMEOSTASIS ENDOPLASMIC RETICULUM PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12323">
        <property type="entry name" value="SR-RELATED CTD ASSOCIATED FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="25"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="397"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="417"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="452"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="483"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW95135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="540" mass="59986" checksum="60933428B58AA7AD" modified="2019-01-16" version="1">MASHQFAIAKASFSAGLLRPDPISLSREDIAQFHSLLNEVVLQCSPKNVQKCKNWILQNITQSTARCTALGKYLTALAISYNEPTFREPAKREPSIKRKRLHLLYLLNDLLNHAKFHVNDASISSKIQPILVSLLSTAASFKGCPKHQRKIADLLQIWEDKGFYSSDYIDKLRETVKNAQESGAAALGENDTSTDGIQDGVVRAAKNIPYVMPAMHGDTSTSWFDLPAGNMMPHIVPNSTRPINPSMIKPLQFVAGPADEVLALAVKTLLEDVQKIYGGETSEEEVILGDIDELGQPIIMDEITGDVLEGEGYYGWSRSFCEKMKQRRKGGQDPVMEHRSHSRSSSPERRKRRYSESDDASVVDRGRRQRRRSYSSSRSPSTEDDRRVARNGSGNLRSQSRTPQRSPSSSSRAPPNANFPPLPTPPSYPNPQMMFSQGMNHNFPPPPPPLPFNNQGPPYGNWIPPPPPIDNTQFNGQQFNQHWPPPPPPPPPPPPPMVPMPPGGWQGQQNQGRGHHTNAWQPPPGPQGRGGRGNYRGRGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9L4</accession>
    <name>A0A3D8T9L4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peroxisomal ATPase PEX6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peroxin-6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_01032</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:13066"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Interacts with PEX1; forming the PEX1-PEX6 AAA ATPase complex, which is composed of a heterohexamer formed by a trimer of PEX1-PEX6 dimers.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Peroxisome membrane</location>
            <topology evidence="7">Peripheral membrane protein</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5553750at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19527">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000108">
        <property type="entry name" value="Peroxisomal biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000109">
        <property type="entry name" value="Peroxisomal biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000039">
        <property type="entry name" value="peroxisome biogenesis factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056995">
        <property type="entry name" value="PEX6_4th_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047533">
        <property type="entry name" value="RecA-like_PEX6_r2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF9">
        <property type="entry name" value="PEROXISOMAL ATPASE PEX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23315">
        <property type="entry name" value="PEX6_4th"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23120">
        <property type="entry name" value="PEX6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2" id="KW-0962">Peroxisome biogenesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="1030"/>
            <end position="1172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="302"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="613"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1307"/>
            <end position="1410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="626"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1367"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1379"/>
            <end position="1393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00062700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW95269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1410" mass="152672" checksum="FDD8E953EDE2062D" modified="2019-01-16" version="1">MGEQIPLPHQRKRKRRRREDKGAISARLVLDDHVKGDVGILSEDLFADLFPTTAQAQENNGSTPDVRHVAISPWTPSEAVEDSSWTVVSVLPSSALAHSTVQFSPSSLSLQVFAEILQKIAPSKLSSHSRSGIEIRIIDVVPLALDTVFVTLEGDVAKRLENGEGTFHSEHPHTNGHIGGHKKPATPEEHLTLAIREALSALKIVHTGDYFSLPLPPHPVTHVPAPPAKVNLCEPVGQGILLPQTKIIIAQTHHHAKVSRKAQSLPLNRALKEVAEDDEDTANDQFYSAAEDRYKTDAAVEDELGTETETEGSSAENELDDLSDDSMDDMISLQAPTLPAHNASGLTTIGPGTPQTIRNGRKANGIHTPGSVFSTLTATTTRAGGQQGRLFKAQGLLKPLPEQILHPKPSSDEDEEARVFVDINSLTKVGCFSGDWVRLEAATEPPANGMGLWGLGSFGNQEPEEPNWRPVKVFGLPEGYSIRPVTKIAGSKQEGRRMSFFESQVQKPSSPTVYLSPVLLANMENTPYCRISVLKRPPTLGTVAAPKITSSSRPPLARELTLLKISTPFSTERMLQNALFAGLQHHFASCTRIVRKGDLIAVPIDEGLGRTLYQSAPTSDDADVDELLRGNRDDPRRSNSLRTTGIGWFKVSYVSAAKTDGAEHFDGDDFWGGVASIVAGSTHMMQTGNENSRLPATMDNSWQYYLGLKTVSKSDFDAMPNALPELRQPHVSALQRRLRELIAAATSPRAIHLKLKPLAILLISTQRNIGKAALASRASADIGLHTFSIDAYDIVSEGSTGSDVKTAGFLEARAERAMTCGPEYCTLLLRHIEALTSDRIASTLKDILAGVRVLIATTTEVDKVPDAIRGLFTHELQMTAPDEWEREGILRSIIDNQTVGLAPDVDLSTVAVKTAALVAGDLVDVVDRALVARSTRLEALASTSTTNENTVTVRDVLVAGGPSGRCLVKADFDLAVDAARKNFADAIGAPKIPNVSWDDVGGLTNVKDAVMETIQLPLERPELFAKGMKKRSGILFYGPPGTGKTLLAKAIATEFSLNFFSVKGPELLNMYIGESEANVRRVFQRARDARPCVVFFDELDSVAPKRGNQGDSGGVMDRIVSQLLAELDGMSDGEDGGGGVFVIGATNRPDLLDAALLRPGRFDKMLYLGVSDTHEKQLTIMEALTRKFTLHPTLSLARVASLLPFTYTGADFYALCSDAMLKAVTRQASLVDTKLLQINKQKSQQGQPKVSTAYFFDHYATEEDVAVMVTEEDFLNAERELIPSVSAKELEHYGRVRGMFEKVADKADVDGGEGEAPTPARRLGIPDRSVPGGSIRSNSDRKGKGKAVSTNTSSGKSKGKEKAVADWNDDDDIDDDREEEAKADTNGYRDKGKGKAVFDPGSVDDDEGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9Q0</accession>
    <name>A0A3D8T9Q0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BP5796_01043</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BP5796</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9Q0"/>
    <dbReference type="OrthoDB" id="2015534at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000155">
        <property type="term" value="F:phosphorelay sensor kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009584">
        <property type="term" value="P:detection of visible light"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00082">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17546">
        <property type="entry name" value="REC_hyHK_CKI1_RcsC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011006">
        <property type="entry name" value="CheY-like_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003018">
        <property type="entry name" value="GAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005467">
        <property type="entry name" value="His_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003661">
        <property type="entry name" value="HisK_dim/P_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036097">
        <property type="entry name" value="HisK_dim/P_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013654">
        <property type="entry name" value="PAS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016132">
        <property type="entry name" value="Phyto_chromo_attachment"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001294">
        <property type="entry name" value="Phytochrome"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013515">
        <property type="entry name" value="Phytochrome_cen-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043150">
        <property type="entry name" value="Phytochrome_PHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001789">
        <property type="entry name" value="Sig_transdc_resp-reg_receiver"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43065:SF10">
        <property type="entry name" value="PEROXIDE STRESS-ACTIVATED HISTIDINE KINASE MAK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43065">
        <property type="entry name" value="SENSOR HISTIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01590">
        <property type="entry name" value="GAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00512">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08446">
        <property type="entry name" value="PAS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00360">
        <property type="entry name" value="PHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00072">
        <property type="entry name" value="Response_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01033">
        <property type="entry name" value="PHYTOCHROME"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00388">
        <property type="entry name" value="HisKA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00448">
        <property type="entry name" value="REC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52172">
        <property type="entry name" value="CheY-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47384">
        <property type="entry name" value="Homodimeric domain of signal transducing histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50109">
        <property type="entry name" value="HIS_KIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50046">
        <property type="entry name" value="PHYTOCHROME_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50110">
        <property type="entry name" value="RESPONSE_REGULATORY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0157">Chromophore</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 12" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="2" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0902">Two-component regulatory system</keyword>
    <feature type="domain" description="PAS" evidence="17">
        <location>
            <begin position="153"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Phytochrome chromophore attachment site" evidence="14">
        <location>
            <begin position="322"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase" evidence="15">
        <location>
            <begin position="697"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="domain" description="Response regulatory" evidence="16">
        <location>
            <begin position="1047"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="33"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="872"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="934"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="33"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="882"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="modified residue" description="4-aspartylphosphate" evidence="12">
        <location>
            <position position="1098"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDW95280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1201" mass="134323" checksum="AB296348A0CC3C5F" modified="2019-01-16" version="1">MSDPDEPNDNQAFYLAPMEFSVERVYPIRSQVNSEQYTASNSKNEDNEGSRQSTAPTKLESKDGLPGPSPPNSHGSSTDGSNESQSRKVSERFKLLPSKSGAPTVWGKHAEGEEPIYRRCEDEPIHTPGAIQSYGALVGLKYSPAGQLEVRIVSENTRRILGYGPEQLFALRSFLDILNPDVRDEMAARVSHVLNSTEDMNSETRLDIFQMSITFPYEPETRLWCAIHLAPKAKGLVICEFEDYSDAFYLKDVSAAKILPVNMVRSTGIDVSPEEFKRSTTSFSKPLPVIEVARQRKQKEFSSLDIFNAMSQSQRQLTQATTLQSVFDVVVGLISELTGFHRVMFYRFDSQKNGSIEAELLNPNASSDIYRGLHYPASDIPKQSRDLYKINRIRILHDRDAETARLVARNESDFKDPLDLTHSYLRAISPVHIKYLINMGVRSTLSISIVINDDLWGLIACHGYGDIGTRVSLPIRELCRNIGECAALNIERLLMFQRIAARKPPVAPPTSQHPATFIAASSTDLLKVFDADFGLINIQDEARAIGRLDPYQEALAMLAYLQARGFTSVQASQKITADYSDIKYAPGIHTISGLLFIPLGSGGVDFIVFFRKGQVKEVKWAGNPHNPTYKPGSEYLEPRTSFKRWVEKISGMSKEWTEDELESASVLGLLYGRFIDIWRQKESASQQSRMTQLLIKNSSQEVRNPLNAMINYLEMALDNKVDELTSEILKRAQKSSKSLIYAIDDLLKLTKAEQGQVFLIDDTFNLSSTVEDVVAAFRKEANKKSLELTVTTHEGIPEMVKGDSTRLRQVLTNLTKNAFEHSVDTGVKLDIRPIQSKDNRCVVSISVQDAGLGMSETQLDDLFQAFEQVLDEDSEPKMKGQESPSPDKNGSVSSLGLGLAVVARYVRNMNGQIRVMSELGKGTIFAIEIPFEHATSPATQPPGESPPSEHAGGSVVEKPNESRALSPSNLPPFMQNMQPTSKQILKVIETRTRIDGAFSPLTDMQTFGQHEATDYDQAASVYSSGSDAISQWPDMDIEGQSSLVHLRILVAEDNPISLRLLNRKLTRRGHEVELSCDGQECHDYYVSNPDGVDVILMDLQMPLVDGPLATRMIRYYEKGDDRKDLVVPGSPKRRVFIFAVSASLYEESRYDYIQSGFDGWLLKPIDFRRLDLLLQCVKIPELRYEAVYRPGKWEQGGLFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q460</accession>
    <name>A0A3D8Q460_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_13138</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000026">
        <property type="protein sequence ID" value="RDW56497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q460"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="487"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW56497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="556" mass="63336" checksum="06B6277F4084FD5C" modified="2019-01-16" version="1">MSGYYRTLLPNNVYDAVWLGIPAFFAYYSLLIIYRLYLSPLANIPGPKTAGMCGLIKNTKSSRSYVVAMTELYAFYHDVYRGGRYVWVVEQMHKRYGEPRVSLLELTKVLTSELVGPVVRIRPNTVHMNDAKFLDQVYGLPGKRRDKSKSQCNSMMTPGAFVATADHELHRRRRAPMSSFFSKQSVNRLEPFIQEALGKTFLRFQQHATAGTPIRLRILFTAATSDIIKYYSFGKSRNSLDAADLEEPFYDAMTSGKMVHVSSYIPWFTKIFTTLPSTVVIWLEPKMKHMLPFFMDLETRLKEISSSKQDESNPTIMPALINSTLPDSEKSPDRLFSEARVILFAGTDTTATAMSNIFYHLLSTPECLRKLKAELEGVMPNIHSTPDSSQLQRLPYLSAVIQETLRLHPPGAMRQERVAPDEDIILNTDSGKHFRIPAGTVMGMTAPLLAKDESLFPRPSEWRPERWIENPNIDKDLLTWSRSSRICLGMNLANAELYVFIAGIFRRYDLYDGTGKQTVPTLELYETKWEDICMVAEHATAYTRDGSYGVRVMVRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q494</accession>
    <name>A0A3D8Q494_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cyanovirin-N domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_13151</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000026">
        <property type="protein sequence ID" value="RDW56510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q494"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.60.10">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011058">
        <property type="entry name" value="Cyanovirin-N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036673">
        <property type="entry name" value="Cyanovirin-N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF64">
        <property type="entry name" value="HETEROKARYON INCOMPATIBILITY DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08881">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26639">
        <property type="entry name" value="Het-6_barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01111">
        <property type="entry name" value="CVNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51322">
        <property type="entry name" value="Cyanovirin-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyanovirin-N" evidence="2">
        <location>
            <begin position="16"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="278"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="311"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW56510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1001" mass="113126" checksum="6BD64B8E4A6C42AA" modified="2019-01-16" version="1">MSAHSLQLNGYYKVMALNTSSRNLTLDGTSLKAECQNEEGHWKDVDLELEQLLGNLSGNFVWMGKDFGKNARDIRLEGSVLHALLPTSPTTWNPTHVDLNDRVCNKDGLLCYMDGLNSFYCYRGSQNRETEHSFTHFSTPIPVDDGHRRYWDAAEAYKIESKKVENEKALRGLPSFQYPPLPSKTSIRLLKIEDSAEASDAIHCSLIVVDLEEDPHYNALSYTWGTPFTNSTPELDAFYRETTSISCQGQLLSVRQNLHDALRRLRKTPPATEKRGRYNKTPIIQAAEDGHTRLVRTLLLEGADVTVQDCFGETALHYAAEKNRLEIVKILVHAGSSISKLDNSRRTPLSCAKQNKHNKVVEFLESMERLGDRPDSKGIFFRRTITNEEYIWIDALCVNQNDNDEKARQVAMMGRIYQSAKSVIVWLGRERQDVHDTSAEDLLMGAWKLEPAGRTGKLDESILDLLLDDPERYLSPSAPPSLKAAATDWLQTVDEREMCRWLLSLPSLNRSWFERAWVIQELIMGRETTVVCGQFQFSWDMFLLLFCIVDSSRALMRRGRNPRGGTGVGFDTIVYRSSAMISRNIGAGTFESPVMMLQRRRRAFNRFGAIPAMSALSLSRNFNTADARDKVFSILSVSSSIKLSTESGQRTIVPDYAQTARDLFLEVGVYLLQTYGPCILSLYKGPETSTIPALPSWIPDLTIPIYSQSLGISVSSSARRIDRIYTSTIYSAALGLKHQQPVHHTPSYSLLLEGFKWNTVEEMILQGLSDIGSDASTLTSWINLLSKLNGTPAERMELLWRTLISDEALGTHPAQNMFNHFQGWVKFLSCIEMIGCSILLVDEITSKRTYPQEVLYPQKSRAQILATLAQIQQDLSSLCIPLSNTESERWKTLDEFTPEKGGYADWYYGLETRARSFAEVMHQKDISRRLFRTQNGYLGTCPEQTKVGDCIFIIPETSVPYVLRPVHDGQYKLIGEAYVHGIMHGEAVRDLAIEMDHFSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q4Q5</accession>
    <name>A0A3D8Q4Q5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">pectinesterase</fullName>
            <ecNumber evidence="4">3.1.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_13073</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl methyl ester](n) + n H2O = [(1-&gt;4)-alpha-D-galacturonosyl](n) + n methanol + n H(+)</text>
            <dbReference type="Rhea" id="RHEA:22380"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14573"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:140522"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.1.1.11"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; pectin degradation; 2-dehydro-3-deoxy-D-gluconate from pectin: step 1/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pectinesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.11" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000025">
        <property type="protein sequence ID" value="RDW56608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2019149at2759"/>
    <dbReference type="UniPathway" id="UPA00545">
        <property type="reaction ID" value="UER00823"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030599">
        <property type="term" value="F:pectinesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042545">
        <property type="term" value="P:cell wall modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045490">
        <property type="term" value="P:pectin catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000014">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000070">
        <property type="entry name" value="Pectinesterase_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321">
        <property type="entry name" value="ACYL-COA THIOESTER HYDROLASE YBHC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31321:SF58">
        <property type="entry name" value="METHYLESTERASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01095">
        <property type="entry name" value="Pectinesterase"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0063">Aspartyl esterase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017662418" description="pectinesterase" evidence="11">
        <location>
            <begin position="23"/>
            <end position="2384"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="12">
        <location>
            <begin position="82"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="12">
        <location>
            <begin position="481"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="12">
        <location>
            <begin position="823"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="12">
        <location>
            <begin position="1190"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="domain" description="Pectinesterase catalytic" evidence="12">
        <location>
            <begin position="1538"/>
            <end position="1832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="39"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1144"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="1144"/>
            <end position="1168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW56608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="2384" mass="249483" checksum="4746EF179FE0A1AD" modified="2019-01-16" version="1">MAKLGIRPALWLAFQLLTQVSAQTPTTTSVYTTVYGCSSVSSECSSSTTTSSLMTSTTTSASSTSGSSSSLTTSIAVASGTVVVDAAGGGQFTAINPAISYAQTFTQPTVLVKAGTYNEVVSVVGNTMVTIVGESPSVGDYSKNKVTISNTVTPMSISSYSVAGITWKNINFVNTATGVAAAVSVRGTRNAFYNCQFISSGSTTITSSLGTTFIANSYIEGTDKLFYNYLGIYVYNSTIVPTASSSTIVYGKGYQASSSALQYSQTVLDSCSISQKAGVTNTYVYLAGANGDGAQAVFKFTSMASFIAPGGTRAVGTNGFFGEYATTGPGSYTYDPKRVDTWMTSAMLSNCTIDYLFANSFSGYSTTSTSWIESTVLNAIAAANVIVSNSVSASSLSSVSSSLTTQVLSITSSSATAASTSVESSSTDIISTSVSMSGLNSTYLPTSSLSALSSSTSVTPSASASTMCVLPSNVPSTAYVVGPIGSCAKYSSISSAIAALPADSTTQYVYILAGTYTEQIPAFARTGPTIFRGESTSPVSQSANLVTLEYSGSVISSAGGSEAYSVFRSTQYSAKKYAFYNINFVNIATITPNYIAIAMDIKAQQVGFYSCGFSSGQGTFLANYGTFFLSGCLIEGSSDFIWGYGAMYISNSKIVSNSPGYSVSAQNYASAYPSQFVFDHCAFVPETTASMSQTTYLGRDYSTSARVTVMNSFLDAHINPAGWSIKATTTNVTFSEYNNTGPGYVPASRVSSAIILTDGSAYSTTNVLGDISWIDSSAIVPFSGFPDSAFVTTSISSVSSTATSTSSLTSSTASALAASSTFVVSTNANGTDYSTVESAISALPNDGAEKVIFIKAGTYTEQIWINRTGKVTLRGETSFANDYTQNLVTIQFNYGVSTSAGQDELTPVINAKKTDSSGLALYNINFVNTFTQTKNSAGLAADFYGNNMAAYGCSFIGFQDTLLANKGTQLFSNCYIEGSVDFIWGFSQAYFHKCYIASNTAGACISAQSRSSASVAGGYIFDSCLVTYTSTYGSTYGSTYLGRPYSNFSVAIYKNSYLDKHINAAGWSVWQTSNPQTSNVLFGEYNNVGPGSWTAATGRASFATNLTDAQVAPYDLGTFLGSTSWIDMTAYNLEPSYSFTGNGTNGTATSTSPTTSASATARANATSGHPSSGITPPSGAIIVSEGATIAGSFANLTAALASLPSDTTSQTIFMYPGSYYEQLSINRAGPVTVIGYQSGDVGKTYTGNQVTVTYARGLSVVAPIAAGHTDAETAVIATASNKISFYNVDFNNTANSDGSTASYVTLAASVYGDQIGFYGCSFIGWQDTLLTGNPSGYAYYESSYIEGAIDFIWGYSQSYFKGCTIGAKKAKSCITAQSRASSTAIGGYVFDQCLFTAAPSSNADLTELIYIGRPYSKFAKVAVKYSYLDSIINPAGWKAWSTTDPRLDSVTFVEYQNSGPGNWENNTAARLAFGNATLLTSDTYTLSSVMASTSWIDMTYWDSITTPQPAAITTPTVSVGNSTTPPDGACIVSKTPITGQTTYSTIAECIAILPSTSVISTVFIYPGTYSEQLTFNRSGATVFRGYADTPSSYAANQVIITNSNGVNTQTDASNSDSATFYSRGKNVKFYNINLINTFGTTADYASLAFAIGNNGNASFYGCQMIGNQDTFDVNAGASVFAYNSYLEGSVDFIWGSGSAYFLASTISPNINSISITADKRSTNTSIGGFVFDQCTVTPSVAGASVAGMTGSISLGRPWNANARVAYIKTYLDSCVSAAGWNQWSSSSPNTNGVLFGEYQNTGPGAVSTNRASFSHQLTDAEATTFLIANFFSSTSWIDFTAVVLSPFVITPAAPTVTITSTVSPTGLQPTVTAISTISYISTTSIPVSVATKNITEKVSTTILSTATDVYQYATVDSTITSYYSLTPVPKTTTVTLNEIVSTTVTLEGTSVTATKLQTVKVTASTTITPSPVTAIQTYTVSDVQTSTVTPNTVTHIVTALSTSIVTSTSVPKAKTTTLKSSTTIYQVITAAMAQPTTTETITSLVSSIKTISSKGITQTTTYFTTIPAGPTVTVAAKKGVTSYVSYTSIVYKTTKITTKLTCTPAAVKAKRDIYEGEFLEDQLARRDNSSSISTATTTIYYTMPPSTSTIYLTTGISTTTTIAATKSTTTATYTSYYYRTSVVPGQTYSSTVSSTKVVLKTTTLPAVTSTYLIDIQGTSIATTSLKGFTSTTTSSVYSTVKTISTVMPAETMQSQTTKTIQSTAVVTLPAETYLSTVTAVKTQTQTTLLQSSTATVTTLISTTVKSTYTPTGTTQTVIKTVRSTARSTTTLPVSTVLIGKTSTSRVPTPTVTTTGTATKSTTVKSTSTITSTVTSTSKGLPTCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q7Q3</accession>
    <name>A0A3D8Q7Q3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q7Q3"/>
    <dbReference type="OrthoDB" id="3501153at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053008">
        <property type="entry name" value="Phomopsin_biosynth_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896">
        <property type="entry name" value="IG-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35896:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW57829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="261" mass="29613" checksum="375CC41135141EA0" modified="2019-01-16" version="1">MSRSTSIIKVMFPNASKYSPLWEHTRTEPISEDEEDLPITPRPRTGMCKKLIFCFLVVLLSCLAIVGAIDLFQRISISVSKSPSSGPKCYCGNSAAEARSLGCKFVPMSAAWLPVHCQDDYLDQEFNHLGPNLDHSWTYYADYERSSTIDLETISNFAGSTTRFYNDWEWHVMHCMFYWRKLHRAQFSGVTLEPRFNTDAHISHCTRLILSRNITSTTVSGVAMGDEIKSKEELKSPAMWSDVRDGYGTHPPPGYLNNIHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q9G8</accession>
    <name>A0A3D8Q9G8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_12237</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q9G8"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF50">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="405"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="432"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="464"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="499"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="53"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="245"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW58307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="546" mass="60011" checksum="7A591CF9A4DA4D2B" modified="2019-01-16" version="1">MMEGGLNTPATADDDSQLAPGTIVFGEVSDSTQPKPTPSDNPNDPLNWSSKRKIVNYAIISFYALMVFSVLSVGPILWVNFMIDLGMTTQELNNQFAANSAGLSVGCVIFIPFALKYGRRPVYITSTLITFGMSIWQAKMKTYGEMVASQLIMGLSTAVSETLVQMTVTDMFFVHERATMNGIYLLMVSIGSFLAPVAAGYIDAAQGWRWVFWWCVIFIGINSILFIFFYEETKFAYHQTIVGSPTPTTSADKTETSKSKSDSSLPEEAMDNSTNGDSGGHINYAIPMNSYRQRLAFSTPTAGSSKTFFRHIYQPFIVLFSFPIVAYVALQYGSTLTWFSILMTMQPTYFGVAPYNFNSTQIGLLSLPPFIGSILGSIYGGPLNDWSIMFFARRNKGIYEPEMRLYLTLLPSLLAPIGLFVYGYGVENGAPWIVPCIGSAFFGFSMIAAGDNALTYLSDSYAEILGDALVAVAFVRNILATIVVFVLTPWITNLGLHNFVTSMGCLSLGINLLVVPMIIYGKRSRIACAGSYAKMQSLQFDPRGIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q9U2</accession>
    <name>A0A3D8Q9U2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Arylsulfatase-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_12370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q9U2"/>
    <dbReference type="OrthoDB" id="103349at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004065">
        <property type="term" value="F:arylsulfatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16025">
        <property type="entry name" value="PAS_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050738">
        <property type="entry name" value="Sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693:SF33">
        <property type="entry name" value="ARYLSULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42693">
        <property type="entry name" value="ARYLSULFATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="5">
        <location>
            <begin position="9"/>
            <end position="435"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW58440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="557" mass="61858" checksum="40D7235DF404AD04" modified="2019-01-16" version="1">MASKVGKQPNFLIIVADDLGFSDTGPYGSEISTPSLDRLAKDGLRMTDFHTAAACSPTRAMLFSGTDNHIAGLGQMAEFLAKNKEAFKDKPGYEGFLNFRIAAMPEILQDAGYLTIFSGKWHLGLTAETSPSSRGFTKSFSYLPGAGSHYNFEPQFDYTNRLPPVLQSGEFWMDGPNFIDRKTDIPDNFYSTDYFADRLIDFLDTRTNEEKEQPFLACLAFTAPHWPLQAPQDIVAKYKGFYDDGPEQLRLRRLRQLQKLGLVPEGIEPAPMNAQTTAWADMTAEERAISAKKMEVFAAMVDRMDTKIGHVLDKLESTGELDNTMVVFMSDNGAEGALLESLPLAGSLGMANIIARWYDNTLENIGAYNSFVGYGDQWALAATAPSRGYKTWSTEGGIRCPCIVRFPRFSRASSGNYTHEFGTVMDVLPTFLEMASVPPVGKRFRGRDVMPVRGKSWVPYLSAAAENIHPTGQDITGWELFGMRAIRRGDWKAVYLPEPKGKGQWELYNLVRDPGEVNDLAEQDVGILNQLLADWEIYIAETGAIEINLGKNTIKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QBE5</accession>
    <name>A0A3D8QBE5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12099</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QBE5"/>
    <dbReference type="OrthoDB" id="3862662at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW59175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="406" mass="45077" checksum="63F5D7A97FD427A2" modified="2019-01-16" version="1">MTLVRKRDVPFPSPTSGMHEPAAPAAWRFTNMALGKDTNLRNCCKYESRATAHLEDLESARTKTVFSKKAFAQKAHPEIDDDHARIHTNKGPANNIPELYTSSLLLSAISRDDSDPLKEPQMKAIVSQIQQIIETYGYGIQRTTSHYFKTLAGWLPIIAPGEIQKEINTLGTKLSLETSFLVLCMCLIVQVRSQEQQTFGEIYSTAKSLFLVLSSGAGESLRVLQGGVLIAYFEHGNAKSKVSAMTLSICSRICTELASSEAQHENTEDTETSRAQWAVLILEQMLDIELDGSKIKASGFVPPEPPLPVDSSYWSHTETQFSDERHSRSPMIAQIGVPGSFLRTIEAVQLLAKVEEFISKSVRSEVYDRQEAKVIDDKLQGLLQCLYKQATCGVEHCCFAISLCNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QBX6</accession>
    <name>A0A3D8QBX6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Polyketide synthase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_12155</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013217">
        <property type="entry name" value="Methyltransf_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032821">
        <property type="entry name" value="PKS_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF20">
        <property type="entry name" value="HYBRID PKS-NRPS SYNTHETASE APDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16197">
        <property type="entry name" value="KAsynt_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08242">
        <property type="entry name" value="Methyltransf_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="8">
        <location>
            <begin position="15"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="9">
        <location>
            <begin position="965"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="7">
        <location>
            <begin position="2440"/>
            <end position="2515"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="6">
        <location>
            <begin position="965"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="6">
        <location>
            <begin position="1117"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="6">
        <location>
            <position position="998"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="6">
        <location>
            <position position="1177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW59231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="2571" mass="279358" checksum="00F679C0A4A49582" modified="2019-01-16" version="1">MTIIDHTTTTTKRMVEPIAIIGSGCRFPGGADTPSKLWSLLHHPRDLSSEPPASRFDVNSFYHPVGTHHGTTDAKKSYWLDESDGSNVAQFDAGFFNIQAGEADAMDPQQRLLLEVVYDGLCAAGQAMEKLHGSDTAVYVGLMSDDWSTMLTRDWDTLPRYTATGLERGIVANRLSYFFDWHGPSMTIDTACSSSMVAVDQAVQVLRSGKSKVAVAAGTNLILSPAMYISESNLGMLSPNGRCAMWDVAADGYARGEGVAAVVLKTLSQALADNDPIECIIRETAVNQDGRTPGLTMPSNTAQAKLIGECYARAGLDPVNKLQDRPQFFHAHGTGTQAGDPQEAEAISTALFPAGSRAAMKADKLLIGSLKTVIGHTEGTAGIASIIATSLAIKHGIVPPNLHFQNLSPKVAPFFKHLQIPTVPTPWPVGESQVRRASVNSFGFGGTNAHCILEQYAPETTMITLPARMPSSPRFTPLLFSAASEAALRMMLSQYLAHLKAHPAIEVEELAYTLQHRRSTFSYRKAIAAPTLQKAIQSLESLINPPSDGKDEANLSTRFSTSPRPAKILGIFTGQGAQWPRMGAQLIETSPFAASRVRELDSALQSLPGVSDRPTWTLKDQLLAGKETSRIAEAAFSQPLCTAVQIILVDILKAAGVLLTAVVGHSSGEIGAAYAAGLVSARDAIRIAYFRGIHAQQAASPNNQALRGAMMAVGTSSQNAHTFCEERFKGRIQVAAVNSNSSITLSGDEDAVDEAEQIFKAQGTFVRKLKVDTAYHSAHMASCARPYLASLEDCGVQAALTSENAMPVWYSSVYNGEPMSRERLTNQYWVDNMCNTVLFAGAIAQAVQQVGTFDLAIEIGPHAALQGPASVTMDEFGAGNVPYTGLLSRGQSDIEQLATALGFIWTRLGSESVQFSAVNTLLSGNESKTVLDDLPSYPFEHHRTYWTDSRIANHFKHRSAIHAPNPVLGAPCFETTTPGEFQWRNILQPSELAWLKGHKLQGQTVFPATAYVSMAIEAITALARETHVDAKISVYKLTNVEIPHAITFDDDAAGVETIFSIVLVEASETVITAEWTCYSVAAGTGKLVQNAKGRASGNLSSVKPDTLPVLKADSGDMVDISDDHFYNNLLSIGYGYSPPFQGVSNIRRKLGYSVGTLYDQSGSAWDDNLILHPGMLDSALQTIFAAWSFPGDTQIWALHVPVSISAITVNAYFTPLSEGGKQSTLQYESSIRSKKHSEIVGDTYLYTEDGSHTFVQFEGAKLVPFSRATPKNDLPMFSHFQYQVASPDGQLAAVGETLSDYEVQVYKDIDRVAYWFVRNVSLSIPEEQRHDLLPHFQKYLKWCDRMVKMVSRNGHPKVTSECNTDSRQDISQILARYEGRKDIRFVQVVGDNLIPVIRAGISMLEHMNQDGLLYAFYEENAICAGPTSRWLARIMSQISHRFPALNILEIGAGTGATTSSVLRAINSTYASYTFTDISSGFFMAAEERFQNESGRMSFKTFNMEKEPSGQGFVEGSYDVVVAVNVLHVSKDMEATMSNVRRLLKPGGFVVVGELTSTELLFSGMTVGTLPGWWIGAETGRPWGPLLTLDRWDAVLKKTGFAGIDTVTPDISASLPISVFVAQAVDDQVTVLRNPLAVTEHPLGIRTDALAVIGGTTPAVSRLGQQAFDILSYRFDDKEFFSTVEDFAASNLARSASASRVITVLSLTDLDGPYLEDLTVGKFEALKTLWATAGALVWVTCGSREDSPYSSMMMGLTHTVKTEHPNLSIQMFDLDPAAQTGGIQPNTATELAETLLRQLVLRSWGTNTDTLLWTAEPQVFVNDGRQLITRLLPDVEKNKRYNSQRRDVLTTAIPAEETLQLVGIGRDQDRALELQKVSPLALAIVPVGKYRTVRITHSLLQTLAVGAAGFLRLCAGIDTETSEVVLALSSSSESPVNVPAQWCIPLLETPAKSTLVSVAASIVAEHILSFTPAGATLLVNEPDPALQSALQMQANSKNVNTVFTTAELRQVRDGHSIFLHPNFPQSVLQSVVPASTAVFVHFSRGVASNAVRDAITKFLPPACLRISEEAVLSHQVIAFSGPEQTTNVSQILHKAFVDADRIGSHTVESIALEHAPSHKTIGEPLAVLDWTATESVPVKVQPIDSGLLFRADRTYLFVGMAAELGQSLALWMITHGARNVVLTSRKPKVNQRFIEDMEKRYGAVVKAMSLDITSRESLRYVHSSITATLPPIAGVINGAMILDDELFARMTYEQFARVTKPKVVGTQLLDELFHDTSLDFFIVASSIASVIGWSGQSNYSAANEFMTSLVCKRRKRGAVGSAINIPAVVGVGYAARSDTFDFDYFQSLGYINISEEDLHALFAEAVLSGRPDQASHVPAQVAMGVNFVPADLHVTEAHRRDVKFSHFVLREENGSEVQAVKTGMPVKVELQTAQNRDEAYTIARDAFLGHLRRILRMTQEENLEDSMTLAEQGVDSLVAVDIRAWFLKEMDVNVPTLKILEGGAIADLVKSALDKMPDAENEAAATSRNVAAVQRVSHTEKETANLSPLLTSNRVFKRRPSESGAISLPVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QC83</accession>
    <name>A0A3D8QC83_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_11988</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QC83"/>
    <dbReference type="OrthoDB" id="2378324at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3210.10">
        <property type="entry name" value="Hypothetical protein af1432"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006674">
        <property type="entry name" value="HD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35569">
        <property type="entry name" value="CYANAMIDE HYDRATASE DDI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35569:SF1">
        <property type="entry name" value="CYANAMIDE HYDRATASE DDI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01966">
        <property type="entry name" value="HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HD" evidence="1">
        <location>
            <begin position="36"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW59064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="235" mass="26139" checksum="FC7DC58FBE1BE29D" modified="2019-01-16" version="1">MSPLPTRQFAGVTIPDTPLITKALEYTKAHSTEFAFNHVQRSMLFGFIIASKISTLSDRDLEVHALAALMHDLGWDPTGELVSKDKRFEVDGANAARDFLRKEATDWDKHRLQLVWDAIALHTTGTIVFHKEPEVQAVAHGIWADIQGPDQVASNLLTWDEYNAVVAELPRLGLMKGMKKLVCHFCETKPATTIDNTVGEWGDKFVAGYDRSGKLTSDYMLASELDGKSLLDDPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QCB6</accession>
    <name>A0A3D8QCB6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">TauD/TfdA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_12172</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QCB6"/>
    <dbReference type="OrthoDB" id="5818554at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051178">
        <property type="entry name" value="TfdA_dioxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779:SF3">
        <property type="entry name" value="(3R)-3-[(CARBOXYMETHYL)AMINO]FATTY ACID OXYGENASE_DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43779">
        <property type="entry name" value="DIOXYGENASE RV0097-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="6">
        <location>
            <begin position="10"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW59248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="346" mass="38866" checksum="363FAC9556A659B7" modified="2019-01-16" version="1">MAVGAPKVTFDPLHPTFGAECYGVDFSQPVTEEDVNSIRDGVAKFGVLVFRNAELDDARHVAFARQLGEIDSSTIFVMPGQKYRLAPFHELTDVGNIEPDGSIVEKGSLTYQIGQGNKLYHVDCSYNPRRVGLSILRAHKLPPKGTGGGTSFADTRTAYEDLDDDKKEKIKDYVLWHSIWHSRRLAAPDCEFLQYMVPEKNSMARHKLVQLHELSNRMNMYIAAHAHHIDGWTKEKSEPVIEALLDHASQDKYTFRIDWENDGDFIIWVGNDKVLSQVNQTKEMTQDNTCVMHRACGGEFEGKYVRDMRRATLLDSSSTAWGLNPTDETSGMLSDVARALGVSQKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QEH9</accession>
    <name>A0A3D8QEH9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Putative chromatin structure-remodeling complex subunit snf21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BP5796_11717</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd17996">
        <property type="entry name" value="DEXHc_SMARCA2_SMARCA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.10:FF:000052">
        <property type="entry name" value="Chromatin structure-remodeling complex subunit snf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000008">
        <property type="entry name" value="Chromatin structure-remodeling complex subunit snf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000843">
        <property type="entry name" value="Chromatin structure-remodeling complex subunit snf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000072">
        <property type="entry name" value="Putative chromatin structure-remodeling complex subunit snf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014978">
        <property type="entry name" value="Gln-Leu-Gln_QLQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029295">
        <property type="entry name" value="SnAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08880">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14619">
        <property type="entry name" value="SnAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00573">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00951">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01314">
        <property type="entry name" value="SnAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51666">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="QLQ" evidence="17">
        <location>
            <begin position="138"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="HSA" evidence="16">
        <location>
            <begin position="365"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="546"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="857"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="13">
        <location>
            <begin position="1272"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="94"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="480"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1094"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1130"/>
            <end position="1239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1368"/>
            <end position="1389"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="410"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="100"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="487"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1167"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1375"/>
            <end position="1386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDW60111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1415" mass="159485" checksum="F2B6ABB71F331FDF" modified="2019-01-16" version="1">MASVQAAPPVQQPGSSITANMTQADMQQILMQYKQMKERGVPEKDPEFMKVHQKLSAIQQHHAYTKQRQAFAQRQQQLAQQNAANVNANGAAGANGVASGTPTNGQSATSNTPAASIPAQSAPAAGGQRNSAAAGGGYFTPEQLGTLKHQIHAFKCLSKNLGIPAHIQQQLFAAKRSTSIPDQAIAGAPPATTAAQQTPNSTDVKPSEAVWVPKTHEYSGFKSPYGGLKKKISYADHRTREERPLVPSIMPSGVDIEKLRYDREIIIHNRMQARLAELKALPANMAHWDMSSGEPVLDESLRKKAIIEMKLIGLYGKQKAFREKIGRQMIQYDNLAMTANRSNYRRMKKQSLREARITEKLEKQQRDARETREKKKHTDYLATVLTHAREVQTAAANQRQKMQKLGRMMLAQHQNIEKEEQKRIERTAKQRLQALKSNDEEAYLKLLDQAKDTRITHLLRQTDGFLSQLAASVKAQQRKAAERYGDGQDEFMAEESSDDEEEEQDTRKIDYYAVAHRIKEEVSKQPTILVGGTLKEYQLKGLQWMISLYNNNLNGILADEMGLGKTIQTISLITYLIEVKKQNGPFLVIVPLSTLTNWNLEFEKWAPGIARVVYKGPPNARKQQQQQIRYGQFQVLLTTYEYIIKDRPVLSKIKWIHMIIDEGHRMKNSQSKLSATLTQYYTTRYRLILTGTPLQNNLPELWALLNFVLPTIFKSVKSFDEWFNTPFANTGGQDKMELTEEEQILVIRRLHKVLRPFLLRRLKKDVEKDLPDKTEKVIKCKFSALQARLYKQMVTHNKLVVSDGKGGKTGARGLSNMIMQLRKLCNHPFVFDEVENQMNPLSTSNDLLWRTAGKFELLDRVLPKYQRSGHRVLMFFQMTAIMDIMEDFLRFRGITFMRLDGTTKSDDRSDLLREFNAPDSPYFMFLLSTRAGGLGLNLQTADTVIIYDSDWNPHQDLQAQDRAHRIGQKNEVRILRLISSNSVEEKILERAKFKLDMDGKVIQAGRFDNKSSETDRDAMLRVMLETAEAAETLEQEEMDDVELNEILARNDDELILFNNMDAERAKDPIYGTGAGSKRVPRLMVESELPEIYMSDGNPIADEPVEAAGRGARERTRVKYDDGLTEEQWLMAVDDDEDSPEAAAARKAARKERREQNRLKRLGQLPGDIEETDGSGSEEEPEPEPEPTPKKARGRKTGKADKRKAEEVDEDEPPTKKRRGPIGRPTKSQAPSAEGMSAKTRTVLQTSLLSVYDSLMKLESSSDVGSDDEDEDGGRLIIGPFVALPPKRDYPDYYVLIKAPISMKMIEKKIKKQEYSSLGDFKKDIQLLCGNAKTYNEDGSIIYVDAVSIENACNSQIDNELKDHPELVELDGGSSVAPTTGANTPTVGNKVKLNFSKKDNEYANGGSSGAQSDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QHK6</accession>
    <name>A0A3D8QHK6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RNA-dependent RNA polymerase</fullName>
            <ecNumber evidence="8">2.7.7.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_11177</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the RdRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.48" evidence="8"/>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031380">
        <property type="term" value="C:nuclear RNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003968">
        <property type="term" value="F:RNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030422">
        <property type="term" value="P:siRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007855">
        <property type="entry name" value="RDRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058752">
        <property type="entry name" value="RDRP_C_head"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057596">
        <property type="entry name" value="RDRP_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079">
        <property type="entry name" value="RNA-DEPENDENT RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23079:SF55">
        <property type="entry name" value="RNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05183">
        <property type="entry name" value="RdRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26253">
        <property type="entry name" value="RdRP_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 8" id="KW-0696">RNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0943">RNA-mediated gene silencing</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="50"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1290"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1294"/>
            <end position="1307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW61285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1461" mass="165511" checksum="EBEC5718386E2728" modified="2019-01-16" version="1">MAYHTQIPASRRSGPAPQGAFGDDIGSGWSTPSAVLLREKADWQLHPELNLRVSGLPSSMDTWMLKKAFEKEGNIVYLNLLGNHGQRTGDATVRFSPPPATAFWVSGLYTLRFGDVTCNVRIRVEPLKKLFQVQSPVRKHISYAETMKLHASTLQFGIMLEENTYMPMCTLTSNKTDDLTFTVDLRQKRIMVDFLVRFQDPRSMGSHDPRVAHSIGYLDRINRFRFEMPFGLLKVLKTTEEGDKDFSFLISLDSPPRFFKKLVEERKTHSPDASSWSEHDTWWRHTDIVYNPYSLKVTRVALAKERPVIDIGRWRSYKFVFPRSRNPKAISDMMRAALQDFNITTTETDAHNTPERSSLLWSMIVQPVSVHANANRDSLVSDGAAQLSADLQSLDDGESMVHLPFEVRYQLEVCLSRDLINEYNISREFVLHLANMARLGSAKARSILEYVAEQGKRVYDPMTIFTNPEALAYSPNTKIPHYCGYTRKATVTPTTIVFNTPTVETTNRVTRHYAKENDDGRFLRVQFTDEDFQGRISSNADKMCDDEVYTRVYRTLYNGIQIGDRHYQFLAFGNSQFRENGAYFFCATEHLTCDDIRKWMGNFKHIRVPAKYAARLGQCFSTTRAIVGLSAPVIVKIPDIERNGHNFSDGVGKISSFLAQMIAAELGYGIIPSAFQFRLGGCKGVLVISDDAKDQEVHIRESQQKFAATYNGLEIIRSAQFSSATLNRQTITILSALGVPDNVFLQMLSEQLADYQSAVEDVEVARTLLLRYVDDNHMTEKIAHLISNGFMACRDPFVLSLLHLWRSWSIKLLKEKAKIIVEEGAFLLGCVDETDSLKGFITPGSSNTNGTDEENLPQIFVQISDRADPSQYGIIQGICLIGRNPSLHPGDIRVVKAIDVPSLHHLRNVVVFPQQGDRDIPSMCSGGDLDGDDFFVIWDKSLRPREWNSEPMDYQSSVKPVELDRSVKVTDLIKFFVRFMKNDALPTIAHNHLAQADYLTGGVKDPKCLELASLHSKAVDYVKTGQPAEMPKRLKVARWPHFMEKKHKPKDKIYHSQKILGQLYDRVESVEFVPQYEEPFDKRILRAFKLEDQLLKSARQVKSQYDTALRRIMAQQEIATEFEVWTTFVLSKPRVGSDYKIQEDMNVISGALKARFQKVCFDRAGGKEYKVLGPFVAAMYQVTKEELDIVLAECRSTKTGGGREVPKRKIEPKNMPLISFPWLFEDVLCRIATGRDVFDDVKDLAILSLAVKTEASQRKCGVGKDDDSQGYIKIDDGVIIHRGEELDIFRPAPDSDELSSDDGESDELYSLQREHKTQPSQFSEQLDIRGYDPVVDLKAEQYPHELYETGVEDVVPRTQLDGLISFSVEDRISSTTEPTSIDDSSLILENTPSQIHSVDNEQVNLPAGTDNRSSIHSSALKEMSQVGKSQEYHAFVEEEEVILEENGPEASLDRLVQLMKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QIA5</accession>
    <name>A0A3D8QIA5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_11464</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QIA5"/>
    <dbReference type="OrthoDB" id="4161376at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06179">
        <property type="entry name" value="MFS_TRI12_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053791">
        <property type="entry name" value="MFS_Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF109">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="64"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="373"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="407"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="431"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="553"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="67"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW61572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="605" mass="64336" checksum="E9013578C329A145" modified="2019-01-16" version="1">MADLSNSRPLSKELVIEHHDRILSQQPHHAPTTPVALHHDNVAPEAVGGLYADMPKGYYLSKGFLGTLLATCLAQISGYLGWVLPANTLSLINISLGGPGGSPNITWVALAWTLGFTIGLALVGRLSDIFGRRWFFIGSSIMAIVGNVIGASAQSVNQLIATNCLNGLAAAGQLSFNVIIGELVPNKLRGPFNALVLSTSIPFAVFGPPIARSLYANTALQWRWSYILGCIINSIAAGVFYFCYFPPSYLQLHVNGKSMMKQLKGLDWIGIFLFAAGLSLFLIGLNWGGQAYPWSSAQVLCTLLIGLATLAGFCCWEAFSGHEYPLIPMRLFRNIKYDAIVACASIGAMVYYSMTVIWPTLCSALFTTNVQEIGWLSCAVGGGLLCGQILGGIGLRVLPRMKIQMTVAAMVMVAFVAALASTTQYTRTRTVVFLLIGSAAAGYVENLTLSSMALVWEPEDIGLVAGAMGSVRTACASIATSLYLSVLSNQLAKYLPKYVTPAAVSAGLPASSLPSLFAGVTSGSFADVPGINATIETVVAQAVKDAYSMSFRTVFLCTLPFGAIILVAALISPNVEDYLTDDVARRLQDGNTEASGADEKKSEVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QIP1</accession>
    <name>A0A3D8QIP1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_11470</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QIP1"/>
    <dbReference type="OrthoDB" id="256333at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000039">
        <property type="entry name" value="Alcohol dehydrogenase AdhP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF8">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="7">
        <location>
            <begin position="8"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW61578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="339" mass="36226" checksum="DFBDC5111D9E0104" modified="2019-01-16" version="1">MKAAQWDPAVKKMVVNDLPIPEPAENQFLVKMLSASLCHSDMMAIAAPDRTEPVTIGHEGVGTITKLHPSAEGKGFKEGDVVGFLYIVGCCFECTGCLVHNLHCETGKQLLQGFSTDGFFAEYAVVDYHNAIILPENFDVKTAAVVFCAGITVFHSLDSSELKPGDWVGVVGCGGLGQMATQYAKAMGCKVVGIDINDAILAEAKAQGADYVFNSMTNKNYVEELLEVTGGGVQSAAVYSNADAAYAGATKIIKLGGVLMVIGLPTNPLQISSMDLALGKYKVKSESTSIPQRMKKAVDFTSKHNIFPVVDTRSSLEDVQDMVDLMHAGKSTKRMAVVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QJ03</accession>
    <name>A0A3D8QJ03_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prion-inhibition and propagation HeLo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_11306</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QJ03"/>
    <dbReference type="OrthoDB" id="3565018at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35186:SF4">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017616359" description="Prion-inhibition and propagation HeLo domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW61414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="35630" checksum="297E1FEE795A3798" modified="2019-01-16" version="1">MLSGVEIAGLVLAAFPLVISAAEHYREGFEPLSKWKRFRTDFIGFLDAIDIEKQLFEQVLERFLISADVPQEELHRFLTQPNHSGWDREDLVERLEARLGPSLPAYVSTIKTMNGLMKELEGLLLIRDGEIEWASEGASRWDYQLKRIRLSFSKKGARTLLALETHNRKLRELLDSNDKLESVKATRKDTAWANIFECIKVHAGHLHSAISNSWRCGCTSPHMTALRLQTCTTGEWASQFHISFPDSRESPLYRKEAVVTINSGQQNMPHDRNQAIHPPSIQDHTSRLRKDFGPKSSSQSLLHEHPNLRSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QL60</accession>
    <name>A0A3D8QL60_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_10831</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QL60"/>
    <dbReference type="OrthoDB" id="276546at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02933">
        <property type="entry name" value="OYE_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001155">
        <property type="entry name" value="OxRdtase_FMN_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045247">
        <property type="entry name" value="Oye-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893:SF93">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22893">
        <property type="entry name" value="NADH OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00724">
        <property type="entry name" value="Oxidored_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADH:flavin oxidoreductase/NADH oxidase N-terminal" evidence="1">
        <location>
            <begin position="7"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW62529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="396" mass="43410" checksum="2C5D52D828733EC2" modified="2019-01-16" version="1">MPFSDPLFEPLQLAGHELQHRIALAPMTRMRASASGVINSTAAEYYSLRATPGGLLISEGLVPHPRGRGYPRSPGIYTTEQVEAWKPITAAVKEKGGVFFAQLWHVGRVGVPSQTGGFPALSATAVPLPGMHPLFGKGETEPYVQGEAMTLSQIEEVTKQFVQAAKNAIAAGFDGIEIHGANGYLFDTFVHSNINDRTDEYGGPLQNRLRFPLQVVDAIVAAIGASKTAIRISPFYELKGTNDANRIQTFSAYTEALEQKGLAYVHMIEARSDQQSEDGQPSNQLSAQDSTLWTFKKILKSTKLVAAGGYSAETAREALLEGKRSVLLISYAWAWTDFSIGKVDIVACGRYYTSNPDLVSRFRHNIPLTPYDRSTLYTNELEGYLGWEVAKVYTLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QL75</accession>
    <name>A0A3D8QL75_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_10854</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3248909at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF3">
        <property type="entry name" value="SPRAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="566"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="689"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="799"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1143"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1175"/>
            <end position="1202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW62552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1297" mass="142442" checksum="A64A1D2071717075" modified="2019-01-16" version="1">MSMAAISAPRYEPLQAHPVNRFPSYTDYREFKSPGVHVAQSPNENDTAFSKNAEYGCKVSASKWSRIKRFLPEWRRQDSVEPILRKGWKPVTLQAPILGGFVFFSIAVIVVLELLSRISAKSSNGGGLAFASDVDNLSNMATFTFLYLPTILSVIYSMLWNWVDLDTKRLEPWFQLSHPDGASGANSLLLQYPFDFLPFIPVTAARKKHWGVFFAGSIMLLVFWAITPLQSAIFNTGTVTRTIETTMADTGRLLSLEAQTSGLNANFLNTGYGISWLNQTLPSFTTANSAMLPFSPANDSGPSSSSEVWTTTTDVYSTNLTCWPAIVTQQTPYPGYTFDNGKGCILSDVVLASTTGTDRYMLNYIGYYNNPVLDWALQNPNCTLEFSNNFLALFATAASRVKSGVYSNLTAIFCEPSYYYMSSSVQVNASSLAVESVRNNDPPLPMSSSLFNTSNFEYIIGTGVPSTDDRSNYPDTSILEQYPRVQDLNVAWPFSQMSGFALALNPMTTDDLASPVVLQSAFERAHKLLFATAFSTLVTSANSDSAGSRPGIRRGQSGSILLVRPIAIVVECAFGLIAILTICLGYVSYCRLSQLASDPASLADIMAKLTKIEDLDKRIPGDGTLTAENLEAAFDGHNFRLKLASSGQASWSYLAIDENRHGPSSRNLEVATRTSKLEATLSPIRPVELGTFAGCVFASIIALAISVLVFMGIWSSEHKGFSLPSNNAVVLSIVENYLPTAFATFLEPAWVILNRFLCLLQPFDDMRRGNACSSRSVEAKYTSLPPQLVLFRALRVRHFLLALVCIVAVSTNGLAVALSALMNENHIEITLPFNSTQRILPFFNGTAIRSDGQITFQDHFYVEMSHLTENTTRPIWVDQNFVYLPFDLDTTRMHSNANTTFAAFRGATTGIGANTTCQKLSSTSGANTVRFVPNNNGTDVEFSTSHVLSNGTRVTCVPQLVANSGDLERVIIQEPFTEGAMALEVMSTMQPAFSNDSTTICASTVVAGWVRVAPASGQGANATRGLNTTFVACMSELLVGEFDILVDAEGHILQSNKTKDASSNTDQYFASNFSQIQLFEQANLLMTPHTTEGFNWHNDSFTSDWMNSLLGYMINSDRLVNPMASVPTTELAASATKSMYQQLFAILIGLNFHVLATSPGGIPLTAGIVVTEPRIFVSAVMTQVCVGILALHLIVAILYYVFRPKRFLPRMPTSIASLILYVSASRALQDYAPEPNESKNRRDNKYGYGRFIDVHGNTRIGIEKQQFVVPLESKNPEARRRRWGLGKVDERQPKTWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QM18</accession>
    <name>A0A3D8QM18_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CENP-V/GFA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_11119</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Gfa family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QM18"/>
    <dbReference type="OrthoDB" id="428768at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016846">
        <property type="term" value="F:carbon-sulfur lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1590.10">
        <property type="entry name" value="glutathione-dependent formaldehyde- activating enzyme (gfa)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006913">
        <property type="entry name" value="CENP-V/GFA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337:SF8">
        <property type="entry name" value="CENP-V_GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33337">
        <property type="entry name" value="GFA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04828">
        <property type="entry name" value="GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51891">
        <property type="entry name" value="CENP_V_GFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CENP-V/GFA" evidence="5">
        <location>
            <begin position="35"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW62817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="186" mass="20259" checksum="AABCA0E371780AF5" modified="2019-01-16" version="1">MAANSATTTTAVDKSKSYFPLAGLANDGWSTEDEATATCFCGAVQLSFPTHGPGFVGSFICNCSDCHKLTASMHATNFTIVDTHLKHLRGRENLKAWGQSQTILVKIPGADNTMTNYFCSTCGSLMYRVGAAFPGVSILRVGSVDDFSLHETKLRPTIEQFNKDRVSWKLPTEGAKQFEEDGLHKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QM43</accession>
    <name>A0A3D8QM43_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Bromodomain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_11171</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QM43"/>
    <dbReference type="OrthoDB" id="784962at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05499">
        <property type="entry name" value="Bromo_BDF1_2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027353">
        <property type="entry name" value="NET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038336">
        <property type="entry name" value="NET_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51525">
        <property type="entry name" value="NET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="306"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="503"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="NET" evidence="5">
        <location>
            <begin position="714"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="148"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="389"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="601"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="677"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="790"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="50"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="201"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="261"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="457"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="610"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="691"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="790"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="823"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="858"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW62869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="873" mass="95317" checksum="99F7317D809FD3E7" modified="2019-01-16" version="1">MTSEQSEGVTFEQKTQPVPSSEKMALDLDINGTSNRDETNLEPAPDASLNDKSATSSSNELTASTVEVNGSSNDDAFKSNNIVASSIDPPPEEFAPAVDLSFSDLPETTVAQPEPSTSSDAHPLASDLASAPVDSAIDAAVEDHLGASSVLPVIEPQESDLRDQAPPQADPMDDTKPKASASSEPELASRSKDELEIDATMATTSISNEQPSASLKDTDMADAPTISQVSKNSREREDDDDEVEPLAKRTKTEERAPTGSLAAQNNQKSAVNGDDDFNDVAITPYQTKEIIKAVKLVVRSNNGKNFRLPVAQLWPNFAEEYKMRIPNEIDLGTIEQRVRTRYYSGWAAFRADVNLLANNALTFNGPDHSITLAADEVRQSLLSKTANIPAEIVQAPKPSKKVAPKHPTPTAETAPRHTPTARRGSKSSALPVAPQGETFALDPSGVPLIRRGSTKLDGGRPKREIHPPKNKDLPYNSTRPKSKKNATELKFCEHVLTELKKQKYWSFTGPFLQPVDPVALGVPNYFSIIKTPMDLQTITDRLNQGQYQKSKDFESDVRLIFANCYKFNPTGNPVHDMGKQTEDLFNGLWDKKQQWIIDHAPAAQSPSSDMESDEEESEEEAENEPAAAASTSGLSARLIDEQQKLISMMTQKNADKASIEVQQTICEMLQRKVNEEAAASSAKKSSKKAKPAMAKPTKKSSTVIKKEKAGTTTNKKSGSRAKYMGTVEKEIVSAGIGLLPESTQDRVLQIIQGDAPDAKADDDGSLELDIESLTEASLWEIYGMIEKHLPGTVKTIRDQKDAERIKARGPTQPKQKKKNKPMSKNEQERKIEHLKNAVQELERHGSGSQEPVMPTVEQQDESSGDESSDSEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUA3</accession>
    <name>A0A3D8QUA3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative allantoate permease-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_10024</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUA3"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF41">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="67"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="163"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="328"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="417"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="446"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="67"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW65332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="506" mass="55922" checksum="9F7330064E9FFD2D" modified="2019-01-16" version="1">MSKGDPEMCLSSDFEAVEAVKAIKAGRGKEVDIAAQILANNIDAVGTEESWTAQEDARLIRRIDWRIVPILFVCATLSGLDKTAISAAAIYNLKKDLNLSGQQYSWVGSAPYFGGLAFMGPSAYMLQHFPPVNYFAFNVLCWGVLEMSMAACTGFGGLFVCRFLLGGFEALLIPATTMLVAMWYKPNEQPARNAIILNVIAPILNGLLAWAVGYHHGSYPAWKIIFLTLGAFTIVWSIVVFFFLPNNPLQAKWLSEREKFMLIQRKATDNTGMESRSFKKEQIWEALLDVKTWLIWFSIVALQVPNGGLTTFNTLIISGLGFNSEKTALLAMPPGAMSTLSGIGLSYLASRTRKYRTLIVAGSILLPLIGAIICYTLPRDNLAGQLIGLYILYTYWAPYVTLVSIYQANVAGHTKKLFLFAWFYISWAAGNIIGPQTFLSYQAPAYTGGTIAMIVCYVVSIILILVYGYVCAASNKKRQDEIAESKGENDWLDLSDKQNVAFKYTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYH2</accession>
    <name>A0A3D8QYH2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Aflatoxin biosynthesis ketoreductase nor-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_09595</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYH2"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051468">
        <property type="entry name" value="Fungal_SecMetab_SDRs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544:SF7">
        <property type="entry name" value="NADB-LER2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43544">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW66846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="248" mass="26438" checksum="200D7C23481C9ECB" modified="2019-01-16" version="1">MPARIYLVTGSNKGVGNGLVAALLSRPGTTVIAGVRDPAQQVSKDLGFLPVGEDSRLITVKLDSTSSSDPVEAAKALQMEHGIKTLDVVIANAGILTYFGTVLSTPPEALLEHFQINTIAPLQLISAMWPLMERSPSPQFYIISSNIASLELSLQLPVPALPYGVSKLAANYIIRKLHLENPSLVSVALNPGWVQTDMGWSSANSIGINEVPVTVEQSVQGLLHVIDTASREKTSGKFVGYDGAEVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QZI8</accession>
    <name>A0A3D8QZI8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_09829</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW67080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QZI8"/>
    <dbReference type="OrthoDB" id="3435579at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW67080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="228" mass="25322" checksum="7F31EB97A46FC973" modified="2019-01-16" version="1">MFWGAVVHVQDAVKLCQIPMVEFAISTALKLMGRLNEVFKLLLDRCGKDMMLLDERCQLDYGLLDTIPESAKTDSMVFEHKTLRKGSCVATVNACSAALQVDKATLQDRSIGSILMLDPCPDNLAFAIRQTASSLMKLHKLSEISIRTLNTMSSVLLSALKQLSVTIEGGADQIEVFEMSLFKIKDSASKIEARAITWALQDGFSILLNILMTVPEITFKLKREQHIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R2Q2</accession>
    <name>A0A3D8R2Q2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">serine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Seryl-tRNA synthetase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Seryl-tRNA(Ser) synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_08992</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="1"/>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R2Q2"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000069">
        <property type="entry name" value="Seryl-tRNA synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="325"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="104"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="110"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="336"/>
            <end position="338"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="352"/>
            <end position="355"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="429"/>
            <end position="432"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="462"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="8">
        <location>
            <position position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW68335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="506" mass="56849" checksum="DFA158DDC7D93ABC" modified="2019-01-16" version="1">MSSSQRSIKCLRCQLQKLNWPTRRYHASPILLKKSNEAIGPKTNIDIKRIRTDAEAIKQNCIDRNYAVQASYPERILQLHRSIQGWQKDALPLRQEIKQVEANLKRKHARTPEQEEPSFKAQRDSVRNEKFDQDELLELARGLKEKLAQIQAKEDAAMDEIVEMAAAIPNSTSDEAPRGHIPKLVDMINEHPKTLHPNRKWRSHTDIGSDLSLLDFAGAATTSGWGWYFLLNEAAQLEQALIQYALKTAMEHGWAIVSPPTMVYGSVAAACGFQPRDQNGETQIYNIAQSAEDVDRKPQMSLVGTAEIPLAGMKAKVTFDESKFPMKVVGVSRAYRAEAGARGVDTKGLYRVHEFTKVEMFGWTLPEDSAATAVFDEMLSIQTTILKSLRLHCRILEMPSTDLGASAVRKRDIEAFFPSRQNIEDGFGEVTSASICTDYQTRRLATRVRAKNGTLGFPFTVNGTAMAVPRVLAAILENGWDEEREEVKIPEVLWPWMGGMKVITKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R3Y2</accession>
    <name>A0A3D8R3Y2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Manganese/iron superoxide dismutase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_09181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the mitochondrial ribosome (mitoribosome), a dedicated translation machinery responsible for the synthesis of mitochondrial genome-encoded proteins, including at least some of the essential transmembrane subunits of the mitochondrial respiratory chain. The mitoribosomes are attached to the mitochondrial inner membrane and translation products are cotranslationally integrated into the membrane.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R3Y2"/>
    <dbReference type="OrthoDB" id="275227at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595">
        <property type="entry name" value="37S RIBOSOMAL PROTEIN S26, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43595:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN MS42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="2">
        <location>
            <begin position="117"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="2">
        <location>
            <begin position="227"/>
            <end position="278"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW68524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="294" mass="32437" checksum="F173DA4A733A1C11" modified="2019-01-16" version="1">MSRPGVFRIATRTAFALQRRCLHRVPPLRHDFSEGVPGLFSAPGFDIAWTQNQSLMIEKLNSVASGKSFESKTPKDILLMAAREPALAAAFNYASMAHNNAFFFNGLSPVQTDIPSELKACLERDFSSIETLRTEMITIASVMFGPGFLWLCKTREGKFTLLTTYLAGSPYPGAHFRRQAVDMNTQNDGTVAGQLRSDILNSEPVNTAGAFGNHATKKPKMAPGGIDLLPVLCVNLWEHVYLPDYGLGANFTEDGRRIGGKKAFVESWWHTIDWNVVAALAELRPKGPQNKFTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="7" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7B4</accession>
    <name>A0A3D8R7B4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_08342</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW69945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7B4"/>
    <dbReference type="OrthoDB" id="10391788at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW69945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="195" mass="21802" checksum="D22EA1C734B45DE8" modified="2019-01-16" version="1">MHPLQRTTPILGRKTTHLVLLRTPTANFHASRPFISTDYTPPIQICRLRLSTDEESAAAKLIRQLREQREKRTKIYVAQIKSLYADAISAELLRQKEALKGVEWLVLDSVLMSSPLCPSLFLSARSSKFLVAKLLLGTSELTVSPHTATATAMARWSRLILGPVTLESSHNALVHHLLLFSVLLWLLGGGRRDKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7I5</accession>
    <name>A0A3D8R7I5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7137 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_08409</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7I5"/>
    <dbReference type="OrthoDB" id="2435509at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055561">
        <property type="entry name" value="DUF7137"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42028:SF1">
        <property type="entry name" value="YALI0E30657P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23585">
        <property type="entry name" value="DUF7137"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7137" evidence="3">
        <location>
            <begin position="90"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="8"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW70012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="262" mass="26750" checksum="FF4377B01A9DDAFE" modified="2019-01-16" version="1">MELTRGLTDSASVAATATASTAQNTGSATATTDNTASGTATGSASGSATGSVTSKASASGSSKKASASGSSKSGSGSSSAKHSTSYDARLPAGGISMMTPAATETSYYKIGEYITFGWNYTSLSATPTAINIMATCTENSQLYTISMNQTVSGTGSVVWDTGKYQSSAVQNPLLTETYTLIIYDAGSSISATAQAGYLSVFDSYTFGMYTPQPYVPIDQFVCATCSGALSSMERAALKMVLGMGLLTVLSFTWFVSGTGIIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7X4</accession>
    <name>A0A3D8R7X4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_08463</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7X4"/>
    <dbReference type="OrthoDB" id="61870at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053225">
        <property type="entry name" value="Acyl-CoA_N-acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20958">
        <property type="entry name" value="GLYCINE N-ACYLTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20958:SF6">
        <property type="entry name" value="GLYCINE N-ACYLTRANSFERASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW70066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="35562" checksum="D147796359699E76" modified="2019-01-16" version="1">MASENSPKFHIFSQEEALSTFLPLLHPHLPQSNPLYNRLQAPQNHPSRRCLFAATFPPSPSPPPSSLQESHTLVFADRSRHAESQIWTFNPLISEHAAKGSVTIEQQAVIRAQLLALILFLKNTAILDAPGWPFSPILKFGCIHDVLTQELRALAVPRQAALHDTQWNLWLAPTRASPFLVQKRALPDGFSVARVPEDQLDIVLSTSSIPRQKETMLTLPNISILNATGRLVAWAYIGIDGTLATLYVLEEYRGLGLASFVAKELLTRLGRGDFGDLGFKGQSGWCHSDVYDGNKGSEAVMRAVGGNVRGVSSYFWVDSELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R868</accession>
    <name>A0A3D8R868_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cation-transporting ATPase</fullName>
            <ecNumber evidence="13">7.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BP5796_08636</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.-" evidence="13"/>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07542">
        <property type="entry name" value="P-type_ATPase_cation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000032">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000119">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1110.10:FF:000057">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000068">
        <property type="entry name" value="Cation-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047819">
        <property type="entry name" value="P5A-ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047821">
        <property type="entry name" value="P5B-type_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01657">
        <property type="entry name" value="P-ATPase-V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF8">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12409">
        <property type="entry name" value="P5-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="557"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1127"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1167"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1214"/>
            <end position="1232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1244"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1282"/>
            <end position="1304"/>
        </location>
    </feature>
    <feature type="domain" description="P5B-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="175"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="15">
        <location>
            <begin position="411"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="733"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="15"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="733"/>
            <end position="746"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF12409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDW70239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1339" mass="149490" checksum="569C6A0C42D4C59D" modified="2019-01-16" version="1">MDTTNGHARQRRSTSRASRASRASRSHAPANGLPYRRDSNLSTTSFLDEEMAQDEIFAGVMSESVPTSISSFAHRRSRADSTTSFTYYQDDDEDGGTPVSDEYDEAILDDESDAQFGEEDSVDLEAGDLALRRASSAASRTSVHDRLLRSDSARTENSNFSRGGRTSQKIYIVTEDLTIVVAGFKNSYFGLACYISICIITLGLGYLLFRWLPRWQVRIIGTPCPLKDCTWVVIENQWGEFVVQDVKSTEYDRSLSTVFGSAEKSYALSYDEDDDPLLEKLRLLDYRYMRFAFHPLKDRFVLSNSWKDPSWTNVKIVRAGIDGEEKESRELVFGKNLIDIKQKTIPQLLVDEAFHPFYVFQVASLILWSVDEYYYYAACIFLISVVSITTTLLETRATMKRLREISKFECDVRVLRNSFWRYVPSGELVPGDIYEVTDPALTQFPCDSVLLAGDCIVNESMLTGESVPVSKVPANDESLQMLNLAASSIAPELARHFLFCGTKIVRARRPQDDKDDEAVGLAMAVRTGFNTTKGALVRSMLFPKPSGFKFYRDSFRYISVMGGIAMIGFIASFVNFMRLGLAWHLIVVRALDLITIVVPPALPATLSIGTNFALSRLKQKNIFCISPQRVNVGGKLDIICFDKTGTLTEDGLDVLGIRVAQRPSHRFSDILTDAFSLLPGAAYERDPTIEYDTHKAILYTMATCHSLRVVDGELVGDPLDLKMFDFTGWSFEEGEQQGGDAEDEEQGGLSPSIARPAPGMEYDLDDNDNAQSTNSPIELGVLKSFEFVSQLRRASVIVRNFGSQGGDIYVKGAPECMKDICNADSFPSDYDELLAYYTHRGFRVIACATKHIAKLNWVKMQKMKRGDAESGLDFIGFIIFENKLKPSTAGVLDELNEAGIRKVMCTGDNILTAISVARECNLIDKTAHCFVPHFAEGDYRDPKARLCWESIDNNIYQLDARTLTPLPPPAEGDASLPYDISNLRNYSLAVSGDVFRWIIDFAPPEVLERMLVCGQVFARMSPDEKHELVEKLQSIGYCCGFCGDGANDCGALKAADVGISLSEAEASVAAPFTSRVFDITCVPEVIREGRAALVTSFSCFKYMSLYSAIQFTSVSFLYASASNLGDFQFLFIDLLLILPIAIFMGWTGPFPVLCRKRPTANLVSRKVLTPLLGQIVICILIQAVGFQAVRRQPWFIPPHLNKEKSNVENSENTTLFLVSCFEYILSGIVLSVGPPFRQAMAHNLPFVVTIVVALLFSSYMLFDPSEGLASFMQLTKMPWDFKIFILVLGVGYIALAWVAENYLLPRLAKFLGMVKQYLTKQPKQRKAYKLILEKMRTAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8J5</accession>
    <name>A0A3D8R8J5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08766</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8J5"/>
    <dbReference type="OrthoDB" id="3549675at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="1">
        <location>
            <begin position="17"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW70369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="135" mass="15568" checksum="4789C3586C1CBC00" modified="2019-01-16" version="1">MEDAGSEGQPISSPPSFGKFAELPKELYSLESQLKIWNFACYIPRNVDVSFEHRKHKYKFHRRSKEPPLLSVCKDSREEALRIYICPFEPGTEIPPSHSIRVNCAVDTLIIDLDSYRDLDPFDYNFSRIGKILSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8L4</accession>
    <name>A0A3D8R8L4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08786</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8L4"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW70389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="140" mass="15163" checksum="419017ACEA994477" modified="2019-01-16" version="1">MSTRKKRGDDEELVALPSDESEEEEEYEDSDVEDDGAAGASDSEEDEDEDAEEEDGDAEEAAPPVKKRKTAPADDEEEAPAPAKKSKVAEPAADDDDAEEEEAEDEEEPEAPAAKKKAAAAVEEEEFDEEEVAADEDDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8M1</accession>
    <name>A0A3D8R8M1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_08789</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8M1"/>
    <dbReference type="OrthoDB" id="2544694at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11578">
        <property type="entry name" value="DUF3237"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW70392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="174" mass="18708" checksum="7C99370DB42F4D2D" modified="2019-01-16" version="1">MASSLPLPTLEHIANIHLDLADAIPSGETPKGTTMWIEITGGTIKSPESASPALNLRVLPGGGDYPTLHAADGMLSLDIHMVALDTTTNDVFRFQNTGFITLDEETDALLLKGQGKSTEFGSNDVRETITCNTGSKQFGWMNYATMVAQGRLLERNGGLGGIEFRVFRFVPAPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8P5</accession>
    <name>A0A3D8R8P5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_08717</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8P5"/>
    <dbReference type="OrthoDB" id="272141at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000082">
        <property type="entry name" value="Shaggy-related protein kinase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF0">
        <property type="entry name" value="PROTEIN KINASE SHAGGY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="35"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW70320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="411" mass="46933" checksum="95EEB6ADE1A0A1D4" modified="2019-01-16" version="1">MSQNRPAAFSSLRMGEVIREKVQDGVTGETRDMQYTQCKIVGNGSFGVVFQTKLSPSGEDAAIKRVLQDKRFKNRELQIMRIVRHPNIVELKAFYYSNGERVRPYSQSFLNTSLQAYQKDEVYLNLVQEYVPETVYRASRYFNKMKTTMPILEVKLYIYQLFRALAYIHSQGICHRDIKPQNLLLDPSSGILKLCDFGSAKILVENEPNVSYICSRYYRAPELIFGATNYTTKIDVWSTGCVMAELMLGQPLFPGESGIDQLVEIIKVLGTPTRDQIRTMNPNYMEHKFPQIKPHPFNKVFRKADANAITLISCLLEYTPTERLSAIDAMVHPFFDELREPGTKLPDSRHPNGAVKDLPVLFDFTRHELSIAPHLNSRLVPPHLKAGLAAQGLDIDNFTPMKKEDMMARLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCT5</accession>
    <name>A0A3D8RCT5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_07718</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RCT5"/>
    <dbReference type="OrthoDB" id="37659at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF13">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17650)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW71684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="253" mass="27235" checksum="6E34AC99FC25B9FE" modified="2019-01-16" version="1">MAAQVALITAGSAGLGAATARLFASQGLRVIVNYSNNRARADALVQELHTLSPLPSDGEVKNFIAIQADLGKREEIARLVEEAVQAMGKLDVVFSNAGWTRVVPFLELDENVNEEDWDRCYLMNVKSHLWLCHASRKYLEATEGCFITTASCAGIKPSGSSLAYSVTKAAQIHLVKGLAKSCAPKIRVNSVSPSLMMTDWGLSFPQASQDAAREATVLKKFVTVEDVAQQVLCFARSKTVTGVNSVLDAGFTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCV6</accession>
    <name>A0A3D8RCV6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_07899</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RCV6"/>
    <dbReference type="OrthoDB" id="3971593at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="108"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="32"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="182"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="258"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="735"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW71865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="809" mass="88984" checksum="2E42A397F138D31A" modified="2019-01-16" version="1">MNALEAQVNDIEYLTESPIALTAISPLDMKVPGQQGSNAGTAQLHRQSTTESPAASGTASTNLIHNHNGKKRKADEPGSPMNNHSGVGNPGPTAAQTRAKRNRYISIACNECKRRKIKCNGNTPCQRCGNLNLECQYAPNCCSSGFKESEEFKQMNAHLTSLQEQVDNLYANLNALRAGRDGSSAFPASSERPVSVSQDSIPPPGISPMNRDRTMPKHPSFRGPTSSAFNLDVAKTTLHNMGYPNLAEGDEGLTTEDVTPLGSPPSKPMARPAVHDTNPRRDPIWAFSKEEMIRLCRVYEEEMGLMYPVANIDQLIIHGTNLYEFIDAAIRTGLVTNSSNGGIKDAQSCVLKMVLACATVTEGSGHSEVGHRLFESVRDVADGILHSEAIEVKNLPFLVLVAIFHFHCDEEALAWRIIGQVARMCIELGLHRRDSLFKTVTDEDERRSAIKLFWSIYVLDRRWSFGTGMPFALQDADIDPSLPEPEVDIPYLNVMITYSRIGSKVWKSVCSFSPAISPSLNVEEIGYLDYQITQWQKSIPPELLLPTSTQPQTSSRAMHRLQILLYLRSNQMRILIYRPVLLSASSIQENLHYANTVVELAKDTIRALTHLNHTSDIYRAQQVCFNYFLISALAVIFLASCHAPVPFSSLCRDEFYMALDLVKGFSNKSFVSKRLWKTIKGLKEIGPRLGLSPDFNSTSGQNGHMGTMPEDAHSSAALAMADLAGQEISTLTNIYGGNQDNNGAKNGSSGSPMNGFQMSHEMTALFEMALQGVNGQSGFAGMDGNRDDPLGANAFGGEEELYRHMRDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCX9</accession>
    <name>A0A3D8RCX9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">L domain-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_07812</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RCX9"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF27">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="249"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="353"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="414"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="827"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="121"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="170"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="196"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="284"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="307"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="356"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="380"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="417"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="836"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="853"/>
            <end position="863"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW71778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1069" mass="115958" checksum="C804D19025B9523B" modified="2019-01-16" version="1">MDQEYRAPPRVSGLPRPTSRLPIPQAVRPSPSLENLQSPLQQSRIGQGISNPRLRSSPSRDSLSAPSTRPRPVPAQSKLREPTSGSAQIRNPSPDTRSPSRQPLLRKSSSSSVLRRPLQPTTVQQAQARQLANENDGGEDCVQGGLGTVTEQNDNPEGPRKLSLSERTMETLQTIPSSPAVQRRKSSFYNTEQPVRSPSRSSHSSSRPNSSHTDASMKLPSRSASSRPTSSSGSAEFSLSDLQLAKNTVKQPLLSSVSTPVKRPTAARTLKTPSSVRSIRAPEISSSKLPAPNTNYALRDASPSAPQPSTRSSIYKPGNQTVAPGRQLKPRASVSGLFRKASMPSLNQVKDAEFLTSSKKVSPTFSSSSSDDRFPDAFSTSSSKGTVISASDDQGATAPKASITLREQIAKAKAAKRAAASGPSSSSNPENEVPVIPTASFDFGLPQDPFDQKVDPKSIKSVLRKRINTARTDGRLNIAALGLKEIPEDVMSMYNLEAISAQDGSWAESVDLTRFVAADNEFEELGEDVFPDIDPRAAFDDDEMAKGNQFGGLETLDLHGNLLKRVPRGLRWLELLTTLNLSNNKLGNDCFTVISQIPSLRDLKVAGNGLSGALDDSISRLEHLEVLDLQRNSLSSLPDSLAELVHLRVLNLAENQLSSLPFQALRDLPIVELIARKNKLSGVLVPQGVEKLSQLQILDVTNNSLTALAHSELDLPALHQLSCSCNRITKLPDISSWSSLLTIAVEDNNISSLPEGFVTLPKIKNADFSGNDLKTLDDRIGAMEALVVFRVSGNPLREKKFTAMATEDLKRALQARIAPEEPVITDTGSVDDEFLTPQTTPTRPSSSDWPITAGTTLDRSGTRSTSLNPVIAAQIASSHTIKTLELHHNCLKEIPSSIAFFAATLTTLSLAHNELTSDTFLTEELELPALKELNLSANTFNSLQPLMQHLIAPQLEKLDISFNRLTFLPVLRSHFPNLRTLLASNNTVRELSPEAVKGLYVLDCNSNELNSLNARIGLLGGPNGLQRLDVRGNRFRVPKYTILEKGTEATLAWLKDRIPVGEADMSDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCY6</accession>
    <name>A0A3D8RCY6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Soluble quino protein glucose dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_07929</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RCY6"/>
    <dbReference type="OrthoDB" id="507128at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054539">
        <property type="entry name" value="Beta-prop_PDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011041">
        <property type="entry name" value="Quinoprot_gluc/sorb_DH_b-prop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051262">
        <property type="entry name" value="SMP-30/CGR1_Lactonase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47572:SF4">
        <property type="entry name" value="LACTONASE DRP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47572">
        <property type="entry name" value="LIPOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22807">
        <property type="entry name" value="TrAA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50952">
        <property type="entry name" value="Soluble quinoprotein glucose dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017820582" evidence="2">
        <location>
            <begin position="22"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroloquinoline quinone-dependent pyranose dehydrogenase beta-propeller" evidence="3">
        <location>
            <begin position="38"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="440"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF22807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW71895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="484" mass="50259" checksum="6546942FF83DE5D1" modified="2019-01-16" version="1">MQFRSNTCLGLWALLIATARGQCNGISNLTTSYATPIAGDGWSASLIANGLVGARGIIFDSNGALLVAQVGFGIAHLTFTDGGGTCLQMANMTYLVNSTILNHGIALSADGKTLYASSSEAVYSWSYDPAAVSVSATNKTLITGMTNDDHTTRTLLMSQMQPGTLIVSRGSNANIDPEAETLSSGHSQIKAFNVTNVTDTPYDFTTSGRLLGWGLRNSVGVAEEPMTGGIYSVENSADEIQRNGTDIHQNNPGEELNFHGMLNSTDNQGGNYGYPNCFAVWNTSIPDAGNLKVGSQMTIDATGNASITDAFCATTAVLPRLTFQAHMAPLDIVFLPNGTEAYVTFHGSWDRSAPVGYKIVSLAFNNGQPVAASDSMTAATDIFVNTDNANCPDGCFRPVGLALDKNQRLFMSSDSTGEIYVLAKTGASTGAGAATGTGTGSAATGTATGTGSAASSTATQSAAARWEIGGMMWLLTVLAVVGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RD16</accession>
    <name>A0A3D8RD16_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_07959</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RD16"/>
    <dbReference type="OrthoDB" id="2140489at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011008">
        <property type="entry name" value="Dimeric_a/b-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36986">
        <property type="entry name" value="UPF0643 PROTEIN PB2B2.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36986:SF1">
        <property type="entry name" value="UPF0643 PROTEIN PB2B2.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54909">
        <property type="entry name" value="Dimeric alpha+beta barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW71925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="224" mass="25439" checksum="684BC68C831D81BB" modified="2019-01-16" version="1">MIAIPRPHSSQMSFPDKDVAEPVSFSGQVISSHKAPTPTNDGRYLLVSPYDEQDHLLDLQTVDTANQLLARALVHLQCQRKDYATAPYIDIFNWQEVFHAVQQLIVANNYNWKEQSFYIVVFRSQIPPTTIYEDLGILDKAAHAEATRSGGFLKYWFGSPDESGRNLATCVWRSLHDARIGSVGEAHRLAAGAARKLYTEWHIERLRLTIKDAATDWEIAQWVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDD6</accession>
    <name>A0A3D8RDD6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Nuclear pore complex protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_07990</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Functions as a component of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Part of the nuclear pore complex (NPC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nuclear pore complex</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the nucleoporin Nup84/Nup107 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDD6"/>
    <dbReference type="OrthoDB" id="3098at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007252">
        <property type="entry name" value="Nup84/Nup107"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003:SF2">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP107"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13003">
        <property type="entry name" value="NUP107-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04121">
        <property type="entry name" value="Nup84_Nup100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="5 7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0811">Translocation</keyword>
    <keyword evidence="1 7" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW71956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1027" mass="117083" checksum="9A2B24C86EE9C7A7" modified="2019-01-16" version="1">MAPMTRSNAAQGSQSDGLLKPSQELYEGSWQMVALPSRPDRELSEEPASSFGESDLMSGDFDDDEDEGPLQYTGPEDHEDILHPLREAANRVGREVERFAEVLDGYNPQRATAESEKHEMTIDLIDHYHNIALDTLDRLREQHSAERRRKDGARWRKKMRRFNTMQDDDMDIEEPEERYSPNSEVQTTLEDLERWEQEAQTWDLLGRLVKLRFQPPGNNHSAALSHGKVLHQYSSEREVWNSFLDSDNLALERRTVLRWLQDTAEESGEDIDVLVQELQQNADRGDIIAHGWLHTKAAIKNQKRINVWPQPLGQSSPDGQQVHLNSSKTEALVTQLDPDSASRQGRKLEAQDEYFERAIWLGCYELLRRGKSASEVKEWCMERTEIWRAVSMSGLPDEASQEEEEDSTPVSSGLWRRMCFALARKGGGDAYERAVYGILSGDIPSVEPVCRSLDDFIFTHYNALLRTQFDHYLQARHQELGGSSQISSFGTFDAIQFHGDTQTAAARLIEGLKTDQRTMEENMQPMKMLQGVLIANTFENFVYQQGLALSKFANESGLSILIPPTREQPEKQEVNKYIALDDHDSLRVLAHVLLVFVNLGADFGGIIRYSVIENIIVSYISFLRLAGKEELIPLYCSQLSGNRRYATLCRNLIDVTDPEQRYTQTRLMRELGLDVQHFVKMQSRYLVQDYPDNSIEYPAANKISLLEDVPMHVDDSGRRIKKDFFGEDAEGIERVDLLLIRSLEWYLLVEGLWSETFLFGTMLYKRFFKHMHLPAARVLASRVPSSMIASSKTPAILGTSQDFIALESETEEDLTEVLDGSADQKKLLKKHLLAEARSFRELEALIELLDNMETTSSMAQLINEEVTPKWQTAWRQQLGKAVQDTREAIGPILHGWLITSQRGLPHLRRLYREMLTAIDDDEFALLREAYLPETILAYISILKFAGYALTRQFLLECMELSTLIAAEDSDLLEPFEKSGRVQELVEAFASASKLLLTSTSGKKSASKSGTKKLKAKGWENQIWNIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDR2</accession>
    <name>A0A3D8RDR2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_08237</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDR2"/>
    <dbReference type="OrthoDB" id="3163292at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051089">
        <property type="entry name" value="prtT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31845:SF21">
        <property type="entry name" value="REGULATORY PROTEIN LEU3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="43"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="85"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW72203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="667" mass="74861" checksum="9D217DC4EB821F9B" modified="2019-01-16" version="1">MDNFEVPVSGNGRQRSAFAVPQNDNNTEAGRKRLRKQEGIKRACTECRQQKLRCDVVRDPFSTCSRCRRLRLACKIDTAFQRIEKRRSKSARQQVETRQPSSGVVALSASHNLSDPAIPDDLETAEPEERSRISGVLPSIAATEPEDISQPYDPTIVFPTYPIIPHDHNTRSHFEDRIDSSDNIPTATATRKLDAIELSPTEVQDLFSDYFENYHQFLPLLNPSKSPSYYYESSRLLFWTTIAIASRRYQADLTLLTALSVSVPRLLWSVLQSVPQNYHDVKALCLLCTWPFPLSSSSSDPTFMLSGTMIHVAMQMGLHRPSQAQDFSKIAMKVPLEELQDRATAWTVCKIVAQSVATGYGQPSTSFDNSILSLSLSNTGVINIPEELRTRLRIESLCHRISKSLYSISEVTDNINQQTTVINLLSDELFQVETDLSHTISPVQQIYLRCAQLHLRLYALFDSNASQNFTQGLVSLYRACESLLSLLLKTEKDILSHSPNYVFQMALAAGFALLKLITSPAAQLLEGTSAKAVFNSAIVIVRKMSVSNNDLPGRLADVLAQLKARGRSPDKSDQWQNFTLKVRSRMSMSVTFDALWHWRKGFEASGSSANTARAATTNNFTDDALNWAGGPSLVQEEFHLDDELFDEFYPLNWMVESPQDYSSIYVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RI84</accession>
    <name>A0A3D8RI84_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_07122</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RI84"/>
    <dbReference type="OrthoDB" id="5970at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="209"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="360"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="311"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="438"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="671"/>
            <end position="783"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW73680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="819" mass="92218" checksum="80F88597932241B6" modified="2019-01-16" version="1">MASIDDDDLIDFSNWEGWALSPYSMLPTTPAPAPTLAPCTFVKPSSDAAAEDSMELRSQDTMKEVVVSTPTWRRGRQKKENLKYPTPASRDMEKQTEMVITPGTSKSIKSQSVILNTSMSVSNKSIPKTMPRKQETLLPNTPKLNPADIAAAAAREFSRIHAPEWAKRELPLQEPLELQEALKEIKSKQNTSRREISRSRSLEDDKTPNNLFVSGLAVGGFDRLERSLRHFFSRYGYIDEIQLGHENDGICSGYAFVRMMSAADATSAINDMHGSRLKDLSSHVSIQRVCDLQDLRLAIAQFSCMEGSDTSQQRFKVEDRNTEDNDNPPKSQDPEKTVLKVVQHGLPDASTDHTDPRKSTKLLVTNLKSTVTEGALWKLFEKYNPAIVHLPLDKETHAPRGFAFVEMHTNKNASDAIKDLQNQDFMSNPLRVKYVSQTQTTRHDHSDTIHPLSEPYHDKHRSSAGWIGDLSPPISSTSAGSTILSSNPTKKPNTDMITERLEGGLSTNFLPIDVETKIQLEIFAHAEHARDQVLNTIEKNIIQLRNDREHESQTLTEIKELLIRSIDEASAEMVALRNSNPKAESVMKALRESNTLAKSQISALKDENSKVNSEIESSGKSNVQAQSEIVAARQMKSEFKAQVGALQKQLLHMKSMQGAQAVERAHLINANMNLHAQNETLQVNIESLQNSFTNEKKLHEIELGKYIAQRKRLQTKNEALNQQAELAMVEKKDLKKRHGLQVENNKRILEKVREEEMKKDIMIEQLKTENKSLKAQIDSLGHSSTSVSSREQTWNEERGNLLTQIQSLLDERARQELYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIW0</accession>
    <name>A0A3D8RIW0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_07424</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIW0"/>
    <dbReference type="OrthoDB" id="5343576at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="330"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW73982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="506" mass="54788" checksum="DD07836B9B89ECA8" modified="2019-01-16" version="1">MPYSSLNYEELTKTLAENFTILADEVQLLSDRKTILEHKLRYAHEQYQQLADKYAPADSAISSTLAKLQLPPDLQVSTPDRAGFVPLPPRKQASSKLQTAVAIRDGRRAAQQLAALSGLSIGSTVSGGNSISAGSSNMRLSARRPSSLSTVLEQDFTVPGKKSSLLCPFAAMTNPSKTTRTSPGGSSTLGSEQMLTPGDGKDPTPHQSSDPICAAMYAEALASPSPSVNGSAAKCPIRYLDQHTPEEVARYFETHKHEIPRSHEVCVKRYQRNEDDIKKLDAKYGNLVSMIQGLGQKHQPMLPTDEEQAAMDAEHHSNERVETWAAGVSTDGLADLDVPEPTPEDDDRDSRFDRPLKEIRVGESPSRPWGISVPIYDDQPERPPSPPPAPVSTKLAAADDERPAGKCPFGHGTTPGLSIQQKADPEAARPAGRCPFGGNTTPAREVPLQTKAEPSSFVYSQPAFIQPPNITKGGLNGPQMIFNGPVFIGYPIEQAITFMERFKGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJ93</accession>
    <name>A0A3D8RJ93_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_07559</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJ93"/>
    <dbReference type="OrthoDB" id="4065319at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051009">
        <property type="entry name" value="PRM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36089">
        <property type="entry name" value="CHITIN SYNTHASE 3 COMPLEX PROTEIN CSI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36089:SF1">
        <property type="entry name" value="CHITIN SYNTHASE 3 COMPLEX PROTEIN CSI2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017693611" evidence="3">
        <location>
            <begin position="29"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="259"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="259"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW74117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="341" mass="34887" checksum="F1D6CF5BF5636413" modified="2019-01-16" version="1">MQIARRSQPSWLLPTIAALAFFSTTTSAASSAAASTTALPNLSSAISSKSVAATATTATDSATDSAGSTITGSAASGTTAAAATSNGLTLPTLSATGGTYTSVSVSVPPTANAPYMHVSNMPEGTVFIAVGAILGFFAMSVLLWRGLVAWSLHRSVKRANMEQYMSMDAKANFRAPAAPFYKYSDRDSMISLSGLPSKGGKKGPRPQSTAAATAPANPSSLFFSPTAGAVGNNAGNRGSTYLPAGYYAAGAPAGNSPYDSTISMTTLDPRPQSQGGYERTPSMGPSYYNPNGASSSTLNLNQAPGNQRTPSVYLDDLFDSNNGGPPLPPPHNNHRQSGQHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJL8</accession>
    <name>A0A3D8RJL8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_07674</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJL8"/>
    <dbReference type="OrthoDB" id="1263307at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052897">
        <property type="entry name" value="Sec-Metab_Biosynth_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37017:SF11">
        <property type="entry name" value="ESTERASE_LIPASE_THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="9"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW74232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="247" mass="26925" checksum="9BF5A6CB750C42BB" modified="2019-01-16" version="1">MSSTKAPIFLLVPGAWHKPSTFSKLRRFLSDNEYESLSVALPSTGGVPATKSTEEDVEVVKNMIEDIVSTGRDIILVCHSYGAIPTSEACKYFTDAKEGRGRIRGMLFLCAFALPPGTDLVMTEATATPGTRIEGDYVVIDDPVLRFYSDLPENEAAEAVAALESFSLRPESPPTTFSPCSIFPSWYVLAERDTVVPPAVAEAMINGMKQLYPGAFEVVERMDTGHSPFLSQPENLGKILIRAAKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RNJ3</accession>
    <name>A0A3D8RNJ3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome-c oxidase assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_06396</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Single-pass membrane protein</topology>
            <orientation evidence="2">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RNJ3"/>
    <dbReference type="OrthoDB" id="1704689at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.370.10:FF:000001">
        <property type="entry name" value="COX11 cytochrome c oxidase assembly homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.370.10">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00155">
        <property type="entry name" value="CtaG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023471">
        <property type="entry name" value="CtaG/Cox11_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007533">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_CtaG"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003465">
        <property type="entry name" value="PRK05089.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320:SF3">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21320">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY PROTEIN COX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04442">
        <property type="entry name" value="CtaG_Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110111">
        <property type="entry name" value="Ctag/Cox11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW75575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="263" mass="29129" checksum="3567ACF6E2EBC5A3" modified="2019-01-16" version="1">MNSLPKILTGLGSRNAAWKCSSCARAARQSSKTPFFNPSLRRNISNSTTLRQSNIPSSFQQKKASFEKKNVSTMYYIVSVMLGTMALSYGSVPMYKMICQTTGWGGQPIKAPGHGGPTGEDPSLRLEPVISAKRIRITFNGSVSDVLPWKFIPQQREVRVLPGETALAFYTATNKSDEDIIGVATYSVTPGQVAQYFSKIQCFCFEEQRLNAGETVDMPVFFYIDPDFVNDPNMRGIEQITLSYTFFKARYDKSGHLSPVPGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RNJ4</accession>
    <name>A0A3D8RNJ4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADP-dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_06458</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RNJ4"/>
    <dbReference type="OrthoDB" id="2310150at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19075">
        <property type="entry name" value="AKR_AKR7A1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020471">
        <property type="entry name" value="AKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050523">
        <property type="entry name" value="AKR_Detox_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364:SF4">
        <property type="entry name" value="NAD(P)-LINKED OXIDOREDUCTASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43364">
        <property type="entry name" value="NADH-SPECIFIC METHYLGLYOXAL REDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00069">
        <property type="entry name" value="ALDKETRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="2">
        <location>
            <begin position="7"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW75637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="319" mass="34593" checksum="D1EC0EED71A34467" modified="2019-01-16" version="1">MSSTPIIIFGAAGFAALDAASQAGFSKILQANSVKDIDTANLYSGSEAALGKQGWPKDFTIHTKAPGFQPGCLKKQSVLDGMEKSLTNLGLSSVETYFLHSPDPDTPIEETLSTISELYEAGKFKHFGLSNFKPEQVQKIYDIQKSNGKVLPTVYQGNYNAAARHIESDLFPVLRKLKISFYAYSPIAGGFLVKSAQTLRDGTDGGRFAEGAPAAKLYNSLYRKESMLDALDEWEAIANGLGISKVALAYRWVTFNSALEASLGDGVILGASKASQLEESLAAFKDGPLDAETVKKIDGFWKKVEKDAPYDNYSVFIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RNL2</accession>
    <name>A0A3D8RNL2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan 1,4-alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">1,4-alpha-D-glucan glucohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glucan 1,4-alpha-glucosidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BP5796_06460</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal (1-&gt;4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RNL2"/>
    <dbReference type="OrthoDB" id="6123450at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004339">
        <property type="term" value="F:glucan 1,4-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05811">
        <property type="entry name" value="CBM20_glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000018">
        <property type="entry name" value="Glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.10:FF:000552">
        <property type="entry name" value="Related to glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034836">
        <property type="entry name" value="CBM20_glucoamylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000165">
        <property type="entry name" value="Glucoamylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046966">
        <property type="entry name" value="Glucoamylase_active_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008291">
        <property type="entry name" value="Glucoamylase_SBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF12">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001031">
        <property type="entry name" value="Glu-a-glcsd_SBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00736">
        <property type="entry name" value="GLHYDRLASE15"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00820">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="CBM20" evidence="15">
        <location>
            <begin position="573"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="526"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="526"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="545"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="237"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="240"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001031-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001031-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDW75639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="680" mass="72012" checksum="3B3BBA142A6F0854" modified="2019-01-16" version="1">MALNLVPSALIPISNCTLSSFIQPIMYSFTSLMLVGSLAWQSILAFPDPSRVEQREALLLKRTVDSFIASESPIALAEILCNIGADGACASGAKAGIVIASPSKTSPDYFYTWTRDSALTFKCLVDTFVNSYSASLQAEIENYINAQAILQGVSNPSGGLNSGGLGEPKFNVDETAFTGSWGRPQRDGPALRATALITYAKWLVANGYSSTANSIIWPIIQNDLSYVTQYWNQTGFDLWEEVSGSSFFTIASQHRALVEGSALATLLGKSCTYCDSQAPQVLCFLQSFWSSSSGYVISNINQNNGRTGKDANSILTSIHLFDPAAIGCDASTFQPCSDRALSNHKVVTDSFRSIYTINSGIAEGVAVAVGRYPEDSYYNGNPWYLNTLAAAEQLYCALYTWKKIGSITVTSTSLAFFQDLVPSITTGTYASSTSTYTTLYNAVYTYADGYMNVVATYAQSNGSLAEQFSKSNGTPLSAYDLTWSYAAFLTAAARRAGVVPYSWGEPTASSVPGTCYSTSAIGTYSSASTGSWPASQTPITGGGSTTSTATGTTSTQTTTTATSTKTSTTSSGCATATSVAVTFNELVTTTYGQTIKISGSVSQLGNWDATQAVALSASAYTSSNPLWSGTITFPAGTVIQYKYINVASSGTVTWEADPNHTYTVPVSCATAVVVSNTWQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RP52</accession>
    <name>A0A3D8RP52_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">very-long-chain enoyl-CoA reductase</fullName>
            <ecNumber evidence="4">1.3.1.93</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BP5796_06606</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a very-long-chain 2,3-saturated fatty acyl-CoA + NADP(+) = a very-long-chain (2E)-enoyl-CoA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14473"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:83724"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="EC" id="1.3.1.93"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.93" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RP52"/>
    <dbReference type="OrthoDB" id="540503at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102758">
        <property type="term" value="F:very-long-chain enoyl-CoA reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1630:FF:000010">
        <property type="entry name" value="Steroid alpha reductase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1630">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF28">
        <property type="entry name" value="VERY-LONG-CHAIN ENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 17" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="254"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="18">
        <location>
            <begin position="159"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00051495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00058640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RDW75785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="310" mass="34930" checksum="EDC423374F59AD6E" modified="2019-01-16" version="1">MASTGPLTLKVTNRSPKQPIKKLPPTIEISSKTTVEDVKNQLAQAAGISDPNRLGLINPESKKILSNRLALVSQIQEVAEGKEILVKDLGPQLGWRFVYVIEYAGPILIHLAFPVLRPYLYKNVQPMSTSQRLSMAMIILHFLKREYETLFVHKFSLATMPARNIFKNCFHYWVLSGLYLAYFIYAPTSYTARESGTFDLLNMVGVALYVFGELSNLYTHQVLSNLRSPGGTERGIPKGFGFDMVTCPNYMFEIIAWLGVVLVTKSLSTAIFTGAGLWQMQQWGVGKEKKYRSEFGDKYKKKRYAVIPGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPR0</accession>
    <name>A0A3D8RPR0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">MADS-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_06781</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MEF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPR0"/>
    <dbReference type="OrthoDB" id="1898716at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008301">
        <property type="term" value="F:DNA binding, bending"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00265">
        <property type="entry name" value="MADS_MEF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1810.10:FF:000013">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1810.10">
        <property type="entry name" value="Transcription factor, MADS-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050142">
        <property type="entry name" value="MADS-box/MEF2_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033896">
        <property type="entry name" value="MEF2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002100">
        <property type="entry name" value="TF_MADSbox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036879">
        <property type="entry name" value="TF_MADSbox_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48019">
        <property type="entry name" value="SERUM RESPONSE FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00319">
        <property type="entry name" value="SRF-TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00404">
        <property type="entry name" value="MADSDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00432">
        <property type="entry name" value="MADS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55455">
        <property type="entry name" value="SRF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00350">
        <property type="entry name" value="MADS_BOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50066">
        <property type="entry name" value="MADS_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MADS-box" evidence="8">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="77"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="128"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="561"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="153"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="287"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="311"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="350"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="492"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="514"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="588"/>
            <end position="620"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW75960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="620" mass="67826" checksum="E97C5C53A97C6577" modified="2019-01-16" version="1">MGRRKIEIKAIKDDRNRSVTFLKRKGGLFKKAHELSVLCSVDVAVIIFGNNKKLYEYSSGDIGEILTRYQYYGGPNEHKGPADFNGKGDDDDDDDDNIGSGPSHHGSVEPQMMQPHFQQQNPAFQHIRHHTPSASPPIPNGAFPHHPQHLQRQHTPQPQIMSRPSSRNAPQRPPSHLAQHIPQGPHPPPNGYAYMPNPAIYQPQNGPVMPHPQAIPQHMQVPQPMPHQPPPPQFQYTPPQQHPQLPPQPQQVQQIYLEEQRRQSAPTFIKQERPPSRQTASPPQPQQQPQQQQQQQQQQQQQQQQPPPQQAQPQQEEQSQQSEPQQSLEPVKRMSVKSRSIFTPIDESRSILSQHWASSTSISEPSRTEPQPANRSQSVDVGAVTRNKPPSPPPRAQAHSKNRVSMSSVSSAQDAFTPPSRTNSAQLGAAGVKRPVLKVQIPDEPSDGGGSATADSASSPRESTGATGSHQPQRKDSSSHSSGVVLPPPSPSASALLSAGASGPPNPFARPHPVSQTTQNSQGATSNSNMNIDTPVSALPSRFMNNEFLPSPSSFYPEWNYRGTGDGNTLPSPLNFATPVVGSGPSFLREDSGERAPPVEKRKSPEGESGGDAKRQKQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RQA4</accession>
    <name>A0A3D8RQA4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycosyltransferase 2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_06885</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RQA4"/>
    <dbReference type="OrthoDB" id="72851at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06421">
        <property type="entry name" value="CESA_CelA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050321">
        <property type="entry name" value="Glycosyltr_2/OpgH_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867">
        <property type="entry name" value="CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43867:SF2">
        <property type="entry name" value="CELLULOSE SYNTHASE CATALYTIC SUBUNIT A [UDP-FORMING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13632">
        <property type="entry name" value="Glyco_trans_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="501"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="639"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="670"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="741"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="9">
        <location>
            <begin position="335"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="79"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="88"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW76064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="767" mass="85646" checksum="0B821A2665BAFEF8" modified="2019-01-16" version="1">MSDFHFSGPGSPTAPSRNQHSYDPLAGGSRPTTPGGSFNNSRASSQVFAQGNASSAYLLEGDIGSSVTLDSLYHGLPQNPQPAFVRRGSTTSSASFEGSTACPTPMPHDEKSPLRTIYNHNQSTTSFHLPHDPRLYKVETIHKHDDVELLSNFRRTLYRLSPLFTLLAVGSYFLYYAYRIHCTIISQQAYGKTYVMAWLFIAAEGCVACPALLHQLYQMLSIRGRSRPRLRLVGDDCPTIDVFITCCGEDVDVVLDTTRAACAVDYPKDRFRVVVLDDGKDENLQAAVENLSSEYPNCYYYARIKIKGVPHHFKAGNLTGGTDLSTKLPGGCGEYIAALDADMIPEPDWLRAIVPHLIQDDKMALVCPPQLFYNIPDNDPLVQSLDTFVHVMEPTKDANGVAWCTGSGYLIRRAALEDIGGWPVGSLAEDTFTSSLLLGSGWKTAFCHEALQYGTVPETFTGHLKQRTRWTLGTLQTALKLKFCLFGDLVKGMSFFARLSAFVFAIDAFFKIFLLMALLTIPIVLISGGQLVAYSTTSQLRWQLRLCFISLVLTRLNEWITYLPSGYRLAQRDTGAQMWMAPYHAMTIIRSFILPTWLGGKTMAFSSSGSVKSELNERDPATRAPLYLRLKVFLWDCDVYLHLLYILFVVAAVTLSTVTGVLKATSVNNCLVYLMTHAFWPPCLWLIALSACATPIRYCIFPPTMPDREDLLDRDPKTGIARPKEHWKKQRYAPTTFWHELQYSTVTVYTIVLFFGSFFVKGIDLTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RQB8</accession>
    <name>A0A3D8RQB8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_06822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the arylamine N-acetyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RQB8"/>
    <dbReference type="OrthoDB" id="10260017at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2140.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001447">
        <property type="entry name" value="Arylamine_N-AcTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053710">
        <property type="entry name" value="Arylamine_NAT_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786:SF0">
        <property type="entry name" value="ARYLAMINE N-ACETYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11786">
        <property type="entry name" value="N-HYDROXYARYLAMINE O-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00797">
        <property type="entry name" value="Acetyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW76001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="323" mass="36782" checksum="DB8B441E48CC87A1" modified="2019-01-16" version="1">MGVFNPAERQKYNPEQIKQYYAHINLPPKAREIDVSSIANTKEGLEFLTVLQRHQLASVPFENLELHYSSHHTISLDPQHLFHKIVERNAGRGGYCMENSCFFGTILRSLGYDIVSIGAKVNEAVQPIAASKNWKGPKFDGWNHMLNIVYIDGKRYVLDVGFGSSGPTFPLPLVENEISVNVGSQEMRLIYDTIPDFTKSDRKLWQYQHRNTSDQPWAPTYAFSELEFTPSDFMVMNHFTSTHRSSWFTTMMVCVKMVLEDGEIVGDVTLFGPEVKKRIKGKSELLAMCDTEEERIKALDEFLGVKLSETEQKGIHGLITELL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RV26</accession>
    <name>A0A3D8RV26_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 14">6-phosphogluconate dehydrogenase, decarboxylating</fullName>
            <ecNumber evidence="10 14">1.1.1.44</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BP5796_05769</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10 14">
            <text>6-phospho-D-gluconate + NADP(+) = D-ribulose 5-phosphate + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:10116"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58121"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="1.1.1.44"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10 14">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 3/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 10">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10 14">Belongs to the 6-phosphogluconate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.44" evidence="10 14"/>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW77917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RV26"/>
    <dbReference type="OrthoDB" id="434986at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00410"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004616">
        <property type="term" value="F:phosphogluconate dehydrogenase (decarboxylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019521">
        <property type="term" value="P:D-gluconate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009051">
        <property type="term" value="P:pentose-phosphate shunt, oxidative branch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.320:FF:000002">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000007">
        <property type="entry name" value="6-phosphogluconate dehydrogenase, decarboxylating"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.320">
        <property type="entry name" value="6-Phosphogluconate Dehydrogenase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006114">
        <property type="entry name" value="6PGDH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006113">
        <property type="entry name" value="6PGDH_Gnd/GntZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006184">
        <property type="entry name" value="6PGdom_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006183">
        <property type="entry name" value="Pgluconate_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00873">
        <property type="entry name" value="gnd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006765">
        <property type="entry name" value="PRK09287.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11811">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00393">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000109">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00076">
        <property type="entry name" value="6PGDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01350">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00461">
        <property type="entry name" value="6PGD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0311">Gluconate utilization</keyword>
    <keyword evidence="5 10 14" id="KW-0521">NADP</keyword>
    <keyword evidence="6 10 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 10 14" id="KW-0570">Pentose shunt</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase C-terminal" evidence="15">
        <location>
            <begin position="181"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="11">
        <location>
            <position position="192"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="12"/>
            <end position="17"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="35"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="77"/>
            <end position="79"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>NADP(+)</name>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="105"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <begin position="131"/>
            <end position="133"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <begin position="188"/>
            <end position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="289"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="449"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="455"/>
        </location>
        <ligand>
            <name>substrate</name>
            <note>ligand shared between dimeric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000109-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDW77917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="492" mass="54555" checksum="C0E32EF4E7C97E71" modified="2019-01-16" version="1">MTEAVADFGLIGLAVMGQNIILNAADHGFTVCAFNRTVSKVDHFLANEAQGKSIVGAHSIEEFAAKLKKPRRMMMLVMAGKPVDDFIETLLPYCEKGDIIIDGGNSHFPDTTRRTKYLAEKGIRFLGTGVSGGEEGARYGPSMMPGGNEEAWPFVKDIFQSISAKSDGEPCCEWVGDEGAGHYVKMVHNGIEYGDMQLICEAYDIMKRGLGMPDKEIGDVFAKWNKGVLDSFLIEITRDIMYFNDDDGTPLLEKIMDSAGQKGTGKWTAINALDLGMPVTLIAEAVLSRCLSSIKDERTRASKVLQFVGRSNKFEGNKEQFLEDLEQALYASKIISYAQGFMLMQEAAKEYKWKLNKPSIALMWRGGCIIRSVFLKDITAAYRQNPDLENLLFSDFFNKAIHTAQPGWRDVISKAALLGIPTPAFSTALSWFDGYRTKDLPANLLQAQRDYFGAHTFKIKPEFANEKYKVGENIHVNWTGRGGNVSASTYQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVM0</accession>
    <name>A0A3D8RVM0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_05766</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW77914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVM0"/>
    <dbReference type="OrthoDB" id="417877at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051104">
        <property type="entry name" value="FAD_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720:SF3">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46720">
        <property type="entry name" value="HYDROXYLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G01460)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding" evidence="5">
        <location>
            <begin position="9"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW77914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="426" mass="46973" checksum="8418DE01B189229E" modified="2019-01-16" version="1">MGVSSNPLNVAIIGAGIGGLALAIGLLRQNVPYTLYEAAAEYSTIGAGVGLGPNALRAMDMIDPRFRALYEDISSGNLTPNKNHVMMDALLIEEGFGKNQGIDPASYGADCYDRTSCHRKALLDIMTGLIPLSTVRFNKRLKSLVQEKDKVIITFEDGEVTEANSVIGCDGVKGATRPVVLGEKYPDQVAATYSGKYAYRSIIPMKDAIEIIGEHAGDAKMFMGPGVNMTTFPISKGTACNAVVFKLDDKPWSYQDWTRPVDPEVMFGDFSTGVDKRLVKLLEWGKPLQWSIWHHLDTPVYYNGLICLLGDSAHATTPHQAAGAGQCLEDALILSRLLGKVTCITQVKPAYQIYDSIRRPRAQRVVRTSQETGLIYAFRHPDFGTDMRKIVEHLNERFLWLWEHDLQSDVVKAEAEFAKIIDQTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVV9</accession>
    <name>A0A3D8RVV9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_05980</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
            <location evidence="2">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CENP-K/MCM22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVV9"/>
    <dbReference type="OrthoDB" id="9445768at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051382">
        <property type="term" value="P:kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020993">
        <property type="entry name" value="Centromere_CenpK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14401">
        <property type="entry name" value="CENTROMERE PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14401:SF6">
        <property type="entry name" value="CENTROMERE PROTEIN K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0137">Centromere</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="224"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="15"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="232"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="259"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW78128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="333" mass="37422" checksum="EB4AC48187DFF073" modified="2019-01-16" version="1">MDDQQRMSRASEAYVARLDRTLKGLQARVKEQEAALEKLKIATAVKVPELDDSPAYLQHLRALKLAHETYTREEPGLPSPESPIPALLALRATKKVITETEECIAEETTTFAALEKRLAKEQADLRDARLMQSMMKSRISSLQDQIDNQSQKSPAQVAKELIRDLKQKQARYDNDTMKLIRDLNSFVDEHLAVMLAAEELGGPVVGEAPEVDESILEAGFNAQGKVRRSKSMKKDDQRQRRIDEIWGPRPQDGDEEEREPWNEKEGAAAEMRELTEQLLNSLVEAEGNGPGAYVDLSRESAAARFLVRSKAAQYHPKDARKLRLIDFGGGFES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RW26</accession>
    <name>A0A3D8RW26_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_05863</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RW26"/>
    <dbReference type="OrthoDB" id="4682787at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF96">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="43"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="205"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="247"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="27"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW78011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="301" mass="33386" checksum="7D143D974325D1E5" modified="2019-01-16" version="1">MIINGQGKFMIVLSAAFLVLNTFFIGLRVYTKTAISKNFSWNDVGMMTVVLTYGSLMALLILGVMNGIGEHIAAGALAKLGDALKYIWFLEVIYVVLTSIMKASIASTLLQWAHKRVHIVLLWTAIVLDALICSVFVFYLIFQCQPVSYAWTFIDPKSKGHCAPLTGQLYMGYALCLVTISLDMLFLFVPFFMLKGRGVSQRVKLYIYGLFGLGVLASIANFIRLAALVKLKASADALFDAAPVFEWSVVEVSIGICVAGILELGPLMRKYNVKGFESYSSFAKLEDDKRPIIIKMQNIER</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWB1</accession>
    <name>A0A3D8RWB1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_06195</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Mitochondrial transcription factor that confers selective promoter recognition on the core subunit of the yeast mitochondrial RNA polymerase. Interacts with DNA in a non-specific manner.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWB1"/>
    <dbReference type="OrthoDB" id="16079at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034245">
        <property type="term" value="C:mitochondrial DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034246">
        <property type="term" value="F:mitochondrial transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006391">
        <property type="term" value="P:transcription initiation at mitochondrial promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.100">
        <property type="entry name" value="Ribosomal RNA adenine dimethylase-like, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023165">
        <property type="entry name" value="rRNA_Ade_diMease-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF17">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE 1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="32"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="106"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW78343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="807" mass="91458" checksum="43D8FA55C8B0268D" modified="2019-01-16" version="1">MLHSLTHPARSALLRSASSRFLYSTRTFHSISSQRLPAASAKPQCRPDSGGGSAKVDALPQEDAAGAESEPKRRVRKSISKTTVKKADSGDDGIPASTSKRQRQKRKEELSPLVEKEVNSLKIKSTRRARKSTSATPQKIIQDKDKDPISANKSATKIRRRTPTVNGEIPEGEVLSEEGIPVTSALRRPKHATPKKLKISQAKPATAKLRGTPIADYLVRAHMTRHNADTEKTRNADRYPKPLDGTRVDITNEALINSIMDRLKPSLQRHIGCDIVEMNPGAGVFSSKLHDVLSPRTHVLLEADPVLYEKECLRPLLDAEGSTYKLLPENGMLWDNIEKAFSKEFLPHQEKFDKDDPRRFQPNNTLLFVANLGYTVPKRFGRIPNFTKLFVHQLLGHIRARTMFQQYGLVRMLLWVADHEKVHVLPRTIMDRRSFAVDAEISCSDIFEVASADSSASSRKRALAADLESTLSVIERMENSKVLPVEGRQSLAEIEARKGLQSKPENGVAPPKRDFYLELEKMEARYAAGGFPKFVDDINTPLELRKPEAERARGTTSRDFQTAEYVRLCYLRHRVNKEAKRSSSIDQLVLDWEGIVGMKDEISRLEGDAAITAQQSLEQRQRKWQYEYDHKSDNDQAMFWNVYEDRVAIRQSPSLLAWDRREAEPIITKEMDFVPAQPLALLDFHPQPPWPVLRSKGQLDAFDFIQPLLWTLPTQSVKRALQSMAHGAYDWIVPECPSLTDPAKGGARDLDELKVRCLTQQQLKEIMESWVRWPFRPSRAQLLLRSGGSLHHVDSPNTEDDDWWEPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWC2</accession>
    <name>A0A3D8RWC2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Celp0028 effector like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_06231</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWC2"/>
    <dbReference type="OrthoDB" id="4831122at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017718349" description="Celp0028 effector like protein" evidence="1">
        <location>
            <begin position="20"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW78379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="30576" checksum="427B414876517F93" modified="2019-01-16" version="1">MRISALISLLSASLASAAAINSPPTHLLSRNSPLNNTLPTNTTIPLSNDTLPANITLLGPDDILVYGQGRMEVMNRTYYESIKHQHFELTTDTPSSINGTVVPYSNATGAVANAKREALAQRDDCQWHEVYTINPTEKFLNWDVPMSSVVHATGNSLTVAVTEGYSIANSISVGASAAYTPIEKILTLTLSIDYTRSWTSTYSAAYSFGVPFGKYAAVVSNPSTTRVSGKVDYGCVGNPSESYEFHADSYTSHGYSNLNWVDGTISLCTGDTWPLHMCLGDGTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2G6</accession>
    <name>A0A3D8S2G6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_05156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2G6"/>
    <dbReference type="OrthoDB" id="3503699at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd10170">
        <property type="entry name" value="ASKHA_NBD_HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187">
        <property type="entry name" value="ALPHA KINASE/ELONGATION FACTOR 2 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14187:SF5">
        <property type="entry name" value="HEAT SHOCK 70 KDA PROTEIN 12A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="682"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="698"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="789"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="824"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="910"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="941"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="961"/>
            <end position="977"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW80458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="977" mass="110332" checksum="E5DFC149A255FB9F" modified="2019-01-16" version="1">MSEVRNILVAADLGTTSMTIRHAPLDYTNGESCVPTELVYDLNTRAVYKWGFEAKEYIDDPRQFSDNPSELFTVDKIKLLLLDPAEAATEAITPAVTAEVYQEKTQEIFDQLGKTPFDVFEDLLVVVFHYVFEDIRSVREHNLLFPQTPGSIELCLAFPSGWPEYVHSRVARSGFKAAMKAGITDGLDHWHFAMENVYTVSETLCGSKEWLRNQVARSRGSDTVERPLRNIEELEVGDKFLPIDIGGGTGCMTVLQLVSKHPLPLAICGAAVDGRFRQWLLGHLLESEYTGDDYANLINRICRKFEDKKKKCGESRRAPWLCEATGLKESSEKGFNKSGLKISFETIEEICFDPVLNELEEAIENIFGLHSGIKAIVFLGQFGAHSPYLRKRMETSQFHSNHTVQLRYGDIDGKQSVVNGAYSERLDITDRFGTRLEAISNYGILMSLNWNLPWVKKLFPDARKSEHAIFERWADRTKCLKVVRWDVPMGTCIDNGFSTQSQETMKDRLLEQLFKKGEAIEFTEYIVVSREPLLPPTSDGFRYTLWTKEHETGWITRANQRIKVTKKPVSWNITMARKQDAHGGFTVPIDSRHLSIKQLKRSRPKFVKFLLDFEITEMQFKCWIEAQIGVAPYYRQLARDMSLTQAEIRSGPSISQGLREDQQMTYPTAPLGRYIEEGEADQNLGSDQGQGSSPLGNVEDDSTDQEEPYVSAQSSLDIHGNEVSPTLQPLDHTEPAQKTFRYEFRDKKEDSPATVQGEDPPVGSEDEPWSPYLKPIEEPTPLARARCKMQQTQKLRSSELSFSGDVYEHPSSPSGSGLGRHDTYQSPHGNRTTIINQTKNKTLVKRKRLATAGQTSVLERERKNARKGKQKARDELKNHLVSAPGSPLLEPRQIDISSEDFVRAPPQVPGTHSASSQPTRAAEYGSLRGGYTSVNIGPGDSSRTSASDFQTARMRGDRRAIRGGRSRISRHYRVRDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2W4</accession>
    <name>A0A3D8S2W4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mitochondrial import receptor subunit TOM20</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Mitochondrial 20 kDa outer membrane protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">Mitochondrial import receptor subunit tom20</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Translocase of outer membrane 20 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BP5796_05345</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the Tom20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2W4"/>
    <dbReference type="OrthoDB" id="2154253at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005742">
        <property type="term" value="C:mitochondrial outer membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016031">
        <property type="term" value="P:tRNA import into mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.960.10:FF:000002">
        <property type="entry name" value="Mitochondrial import receptor subunit TOM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.10">
        <property type="entry name" value="Mitochondrial outer membrane translocase complex, subunit Tom20 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002056">
        <property type="entry name" value="MAS20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023392">
        <property type="entry name" value="Tom20_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00985">
        <property type="entry name" value="3a0801s04tom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12430:SF0">
        <property type="entry name" value="TRANSLOCASE OF OUTER MITOCHONDRIAL MEMBRANE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02064">
        <property type="entry name" value="MAS20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037707">
        <property type="entry name" value="MAS20_rcpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00351">
        <property type="entry name" value="OM20RECEPTOR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47157">
        <property type="entry name" value="Mitochondrial import receptor subunit Tom20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 14" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 16" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00068548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00073975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00080405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR037707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDW80647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="172" mass="18870" checksum="4B80E47E0D9339D6" modified="2019-01-16" version="1">MVQTSTIVAASVGTFATGLLAYAVYFDHRRRTDPNFRKQLKKESKKQARAAKEEAEAHTTRQRQAIRAALQQAKDEGFPIDVEEKEAYFMNEVARGESLSSEGTDNVEAALCFYKALKVYPQPSDLVTIYDKTVPKPVLDILAEMIALDPSLNMAPFSGGSPESGIPSVGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S378</accession>
    <name>A0A3D8S378_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">LYR motif-containing protein Cup1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_05249</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S378"/>
    <dbReference type="OrthoDB" id="5521299at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd20273">
        <property type="entry name" value="Complex1_LYR_unchar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046896">
        <property type="entry name" value="Cup1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20263">
        <property type="entry name" value="LYRM2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LYR motif-containing protein Cup1-like N-terminal" evidence="1">
        <location>
            <begin position="42"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW80551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="368" mass="42142" checksum="AAFA8CEA61F0AE6B" modified="2019-01-16" version="1">MSRLPTPASTFLRWAPKPPVPAAPEGLKYAPCTLPQYAIHIFRHTLRAASYLPEPYLRASVKNKVCESFRRRRTKLRRATEPASHVDSHQRLKKYIVTARNELNVLRRAALGQKEPLEKVINDAYGRTGRPRRFLVANLLKEDEACIPSPDTTLETYITSIVEKPRSFEPSEKLQTLIASQQRSHPFYSQRKKIRNISPTLPKTNLWGRPLPRKLADSKKARFWSDLFDRLLPPLPTHESSRLKAICNSSPDLLPRRARRIKSLAAEHKASDKTKAEERESLEYDQKKFRLSTRGWKRLWGSVLAQSPEMELSEDSKKWVVTWPPVAANAQAGKVTQPAARDRELFIGFQPPIEAPKKTKRALNTVQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3E2</accession>
    <name>A0A3D8S3E2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_05521</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TTI2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3E2"/>
    <dbReference type="OrthoDB" id="6417021at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110078">
        <property type="term" value="C:TTT Hsp90 cochaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018870">
        <property type="entry name" value="Tti2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32226">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32226:SF2">
        <property type="entry name" value="TELO2-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10521">
        <property type="entry name" value="Tti2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="269"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00034736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW80823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="544" mass="60914" checksum="7AC29AE4900BE841" modified="2019-01-16" version="1">MFTQARKSLRKLPESNEAAGLDLGNTALPSEYTLAQLQHEFLEDDLGKDKPEQFENVLLLSQCLKHNERLIPAESDVSAAGKILSWLSTVILPDATFVANDELPEGDEDGAQMSQSLQAAISMGEAGLDAITNLIQLDTHVALKLENQVLLSLIAFTDKRDVWTSQKSLSKAQAILSRCSEQVRSKEFLVDFLLRETIQPLFSKTKPAAITSTGRKAMPTSAPPRRFETADMDPANKPWKFKDLWAVTVFNWIVDHTEETIVTESWPLFIPPLLTLIDDLKTSIRTRGLETLSSFLPKFSTKLLKQTGLGQVFEEAITPTLTYLPNLTPLKESLQLLGPAYNALYALADAQYSPEDTGLKMKFLDRVMREGVLQAYSHSSEHVQIVELLVKETNILIKKMGIHAVKYLKDILSILSTILSNPFSSAQPTLSRQAIITLQTLILNCWPRMTEPMHRVEIIKVLVLCWNTLEAEQHEEGGTNEMEQGQREREKMKEEIKIAGRLLVASVSCVEEENRKVDIREELTPLMKVDAGVPEIFGLEALPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3J6</accession>
    <name>A0A3D8S3J6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_05536</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3J6"/>
    <dbReference type="OrthoDB" id="5416983at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="212"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="851"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="897"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1021"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1172"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="505"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="527"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="668"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="684"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="723"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="757"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="909"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1172"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1194"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1210"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1243"/>
            <end position="1259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW80838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1259" mass="134385" checksum="A8D3B4287D2BED7E" modified="2019-01-16" version="1">MATEATNDIAATPSTIPDHELNKTETKTENAPTDVPILNGVTGGDGIKQESESEAVDGAANSAEVSVSGGSDTEASKTDGAKAQADDKGHARTASTVKKFTSFKPVSVNKTFLAAKSATATAPSKLGDKNTAGTSTTQTGSTATLTARPRLVAKSGSGIGSAAPRTSASANGSKPGAAPDASAVWNKNRPAPAPEPKRFTDEELKQRYGIHLATRLQSDDPGKQATWADIDDDDDDWAPETIEWTDGTKITLPQADDVASTPTPEPEPIPAVKETKAVEAPKPKSPAPVQPASSPTIKTANFGSGRAGLVLKGVAEKPTLVAKPPGPPTPVKSPWAPLPPVDKVAPVNIDLPQAPSQQQQSRFGQRDPHGFQNMPPPPAKEIAADDFSRSWRDSNANTSRELYNSQSGRYEPVNENRRGVARNDPHSRQPAVLQRPGNQDHPEPSAAFQTHRAGNQESSYGRRRTSSNASGGSGLLRRMSRGHDLPPPQELLSTRRGSLAAVSDAPSSPRTYSPSGQHPNQRGYRASPVISHPSPHPVHGQTVPQMLDGQVPIQQTQEEILEEQKKIMRDKREAAIKRRQDEEAKEEAAKKERIRLKLEAMGPAPESKAKKEDKPSVPTQIQARDPIDATSATGSAKTKPSDSQSNENSPETKTVESRLPSQLPRVNGIHSSSVPPSNSIGSEGRNSQTWQSASSSNPDRFTNWGSAPPQPTSSRNVWGPPTNDRTLGNGTFNPELSRLPEMHPTASNPGPIGPPNATRNNTNGQYQQNRAREPYSARPAPIGPPNRHEQQRAAWNTLPEKLAQDDAVLVQQQAEELARRRAMEAAGIVSDVPQPIFKDTWRQVTLNEDGTRSAVQSNTTITHGDSSTKPPAWTQSAADNNKQEAVQPQFNDTWRRAGVEQSGPRTDLLASTTINNGSLGGINSTPSRGSRFFPTRDVRLEDPTTTFERPGSPSPPPPTMAGHPAYDGDVSHPHVSLPRPAPVVKLPPAMTPIGPPKPATFAAAIAAPPPQAGNSYAARHDAGGRMPTAQHNPAHPSPGGWQDRINSLIGRKNSPPKSHALAVDSSSKNALELPRPQLVATVSFPAATPGELLAEENKVFSKPPAEECFEEQEMGSLPLIRVPNKAPEMAWNLAQPPKSLPRKFMVSHTTTVEPISLGPSHTLIILLPGQTEAKSLNAPSQRQKSNPRRGRGGSSRNPSNPSRGGRTRDASSGFSTPNTEQLTSTNSSPNPSRGSYRGRGANHSGSSWTNRHVSTPVHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S9A0</accession>
    <name>A0A3D8S9A0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">P-loop containing nucleoside triphosphate hydrolase protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_04437</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW82946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2320933at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18025">
        <property type="entry name" value="DEXHc_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001039">
        <property type="entry name" value="ATP-dependent RNA helicase DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055124">
        <property type="entry name" value="PIN-like_DDX60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052431">
        <property type="entry name" value="SKI2_subfamily_helicases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059032">
        <property type="entry name" value="WHD_DDX60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533">
        <property type="entry name" value="DEAD/H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533:SF4">
        <property type="entry name" value="DEAD_H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23002">
        <property type="entry name" value="PIN-like_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26076">
        <property type="entry name" value="WHD_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="788"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="1253"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="549"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1103"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1197"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="549"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="590"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1108"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1201"/>
            <end position="1211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW82946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1835" mass="205241" checksum="16ADB207052E2276" modified="2019-01-16" version="1">MAEGPPEQEPARGAQSISVWYDSSRPIWIDLVGDYAGKELFLIEGDSLLRECFEDERIDFNDGFQLLHAVYVVERFLENLVKRYCQFHIGFFAEHEYLCIPHGAPANKWSRYLLARSAIIQHLALRLPSSGTDIEIHEFPSLGSDAFKEYLHVSPIHFVMAHDGAAKYNTDDTSEIAKCSRNWLRGIIWHFNIHQLNVALINRIEFRDSKVFTMIMESFTLPSPLKLQMTSDFNEEIKAAQALMADFVVSQAGQQQSELLKAAKLEPLESNEEMNLGPYLVAHAMAKLLDVQTNTFLASAFMLHSLVLEKVSLPQRRLPLITFDEKFEEEIDDFFAKFSGAARSIIDSSEWRELLNSRDDEGEEADTVDLVDGRLFRATLQAFADGKLTAASTEPFQADWTTATRIIKSTTGSGSNLTFADLHTPKSSQANAEDAHISEDANDLAVLPFTSPVFDKHLECINVETDNSVAARLGSMRIYRETTHWHNHRKPLNPKLAPVVKVSKWKNPLRLNQFYMSEMTSYAASLTGAKGKALEPETITVGPKQLVKIAEKSSKPEKPAKPEKKSKKEELQDAKGPAKKGTKKAAAGLSKKEQMIAENKERKGSSEADKVFSAWSMVMKGLDAVSDYQDRYLRTTSYLNNLDSTKASYLESEVNTYILQSLLSWWADYCKASKKADGYHVVALIWTTIRSLCTTTSPITKEIILHMTKVASLLGITDALSPIEPSGTDRKLSFVFKYPASAQPLRIDMPQVNFQLDYCGPYMPRMLDAKPDPRVTSFVPDGWQREVLDDLDANRSVFVVAPTSAGKTFISFYAMESILRADNDGVLIYVAPTKALVNQIAAEVQGRFSKKFPQPGKGVWAIHTRDYRVNNSTGCQILVTVPHILQIMLLSPSNAKSWAPRVRRIIFDEIHSIGQAEDGVVWEQLLLLAPCPIIALSATVGNPESFNDWLTETQKASGHEMKMIQHSTRYSDLRKYMYEPPKTFQFSGFGRSYGGGLGLDGLEGFEPFHPISSLIDKSRGMPDDLALEPRDCFSLWKAMCKVQNDKYKVPVSLDPAKALPACIRKADIFAWEKGLKTVLKEWMGDSESPFDQIVSELGPLETAGKAATNGNSEPLSSQSSSVDNDIVDPLDLKSTTLPLLFQLHRRRALPAILFNYDRSECENVARSVLKQLVDAENKWKEGREWKKLMEGFEKYLEQKSKKSRKPVKPSKKGNDDEDGGSKMDRMRDDAAADGVSIYDNFDPNAPQAEFSFANPKHLPKAELDDYVKQLRRKYIAEDLIDLLRRGIGVHHAGMNRKYRQSVEMLFRKGFLRVVIATGTLSLGINMPCATVVFSGDSVYLTALNFRQAAGRSGRRGFDLLGNVVFQGIPRERASRLLSSRLPELTGHFPITTTLVLRLCTLLNDSKSSPYAVKAINSLLSQPRLYLGGKSFKEQVLHHLRFSIEYLRRNQLLGPRGEPVEFTSIVSHLYFTENSSFAFHALLRGGYFHNLCADIETKGDEITQTLILVLSHLFARRVVREVKDEEEIEKIKRSPSLVYLPDMPTEAVEILRKHNADTLDIFTTYVKTFAAQHVEGEESQLPFTKTPIGADAMSSTNGKAANGIVQSVDFLPTLSAPHARSAFVALSGHGDDFKTIEDLCSSTREGVFLESAVIPHLEIHPDETRSPLNAYLLDFFMHGSVKPLEEANGIRASDVWFALNDFSMVLATICTSLAIYLGLGSTEDPEMLDVMGSGDAAENDADEQIAATDTETTISSASSAPSAPPTLIKKGRKGIVDDWDAGEDALVAEEDFLKNEMVEEGRGETDDEEYEKLMNVYRAFRKLKTEFDEKFRAIWA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S9C0</accession>
    <name>A0A3D8S9C0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_04443</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW82952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S9C0"/>
    <dbReference type="OrthoDB" id="4158815at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="236"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="180"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW82952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="298" mass="32003" checksum="3E0C93A5C3FA89D8" modified="2019-01-16" version="1">MSNFHTNKWYQILVALPSKADQSMVGSVLNSRGGTGQVYFNSTNITAPEQQWQIFPYNSSYYVLRSKASDSFGYLNTAAAALETTLGNTVPRMLNSTFSDDSCLWTISPWGDGTFYFTNAANGSAWHLLVKQGSQMAMSSNITAPQTGQSFTFNATGTIDDSSYSSVILRGSTTVESSSISISTSTASASPTSSDSKGGLSTAASAAIGASIGGVAVIVLLIVGFLCYRRRRNKTNKGYAKPQSPDTPTKQPLYSEMPASVQHTNEATELPAQHQPAVELFEMDGSSRIPELPEQHKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S9H6</accession>
    <name>A0A3D8S9H6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Phosphoribosylformylglycinamidine synthase</fullName>
            <ecNumber evidence="4">6.3.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Formylglycinamide ribonucleotide amidotransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Formylglycinamide ribotide amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BP5796_04500</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-formamido-N(1)-(5-O-phospho-beta-D-ribosyl)acetamidine + L-glutamate + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17129"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:147286"/>
            <dbReference type="ChEBI" id="CHEBI:147287"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.5.3"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the FGAMS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.3" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6666987at2759"/>
    <dbReference type="UniPathway" id="UPA00074">
        <property type="reaction ID" value="UER00128"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004642">
        <property type="term" value="F:phosphoribosylformylglycinamidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006189">
        <property type="term" value="P:'de novo' IMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01740">
        <property type="entry name" value="GATase1_FGAR_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02203">
        <property type="entry name" value="PurL_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02204">
        <property type="entry name" value="PurL_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.750:FF:000002">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000002">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.10:FF:000005">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000008">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000005">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.650.10:FF:000024">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.750">
        <property type="entry name" value="Phosphoribosylformylglycinamidine synthase, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.650.10">
        <property type="entry name" value="PurM-like C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.10">
        <property type="entry name" value="PurM-like, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00419">
        <property type="entry name" value="PurL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040707">
        <property type="entry name" value="FGAR-AT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055181">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010073">
        <property type="entry name" value="PurL_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041609">
        <property type="entry name" value="PurL_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010918">
        <property type="entry name" value="PurM-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036676">
        <property type="entry name" value="PurM-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036921">
        <property type="entry name" value="PurM-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036604">
        <property type="entry name" value="PurS-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01735">
        <property type="entry name" value="FGAM_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003672">
        <property type="entry name" value="PRK05297.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10099:SF1">
        <property type="entry name" value="PHOSPHORIBOSYLFORMYLGLYCINAMIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02769">
        <property type="entry name" value="AIRS_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18072">
        <property type="entry name" value="FGAR-AT_linker"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18076">
        <property type="entry name" value="FGAR-AT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22689">
        <property type="entry name" value="FGAR-AT_PurM_N-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13507">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01211">
        <property type="entry name" value="GATase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109736">
        <property type="entry name" value="FGAM synthase PurL, linker domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56042">
        <property type="entry name" value="PurM C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55326">
        <property type="entry name" value="PurM N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82697">
        <property type="entry name" value="PurS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase N-terminal" evidence="20">
        <location>
            <begin position="42"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosylformylglycinamidine synthase linker" evidence="19">
        <location>
            <begin position="183"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="18">
        <location>
            <begin position="441"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="FGAR-AT PurM N-terminal-like" evidence="21">
        <location>
            <begin position="679"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="domain" description="PurM-like C-terminal" evidence="18">
        <location>
            <begin position="877"/>
            <end position="1010"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00029823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00052585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00057317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00071729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF02769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF18072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF18076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF22689"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RDW83009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1355" mass="147655" checksum="4A6F6F34BADF27F1" modified="2019-01-16" version="1">MEYLVSPGDAALSPAESKKLLERINKYEGVEVTEIRAFWIHYTHLKSSDADAVKVAEAKVQQLIPGVINSPAKSLLTGNSASKVFYITPRNISPWSSKATSIAHVCGLKSQVHRIERGRAILVQYTELAPGIDIPFKDELYDRMTENITTEEPNLHEMFAEGDPYPLEVIDLSAPGSTPIEILQAYNKERGLALDQLEMEYLVQAYTQLGRQPYDIELFMFAQVNSEHCRHKQFNANWTIDGIPKGRSLFEMIRNTHKKNPDFVVSAYSDNAAVLEGEMASFWAPDYSTGSWRQTKEKVHFLAKVETHNHPTAISPFPGAATGSGGEIRDEGAVGRGSKPKAGLCGFWVSDLFIPDHKQPWEIDVGKPAHYASSLDIMLEAPIGSARFNNEFGRPALTGCFRTLLADVDGDIRGFHKPIMIAGGVGTVRPQHALKDGRDVKEGAHIIVLGGPAMLIGLGGGAASSNASGEGSVELDFDSVQRGNPEMERRAQMVIDSCTALGDSNPIAFIHDVGAGGLSNALPELVKDAGFGGKFELRQVESADRSMSPLQIWCCEAQERYVMLVNQDGLNRFVNIANRERCGFSDVGTVVAKDNEGGVPKLVLTDRESREYPTPIDLPMSVLFPKGRTLERIVESQQPKLRPFNALESLKKAFGPTTPEPELLQEAIKRVLRIPAVGSKSFLITIGDRTVGGMTVRDQMVGPWQTPVADVAVTAAALNIGDKLTHGEAFSMGEKPTLALISAAASARMAVVESLMNLAAADIKGGLNRVRLSANWMAAVNHPGEGAALYEAVEAIGMELCPKLGISIPVGKDSTSMQARWKDANGDAKSVTAPVTAVISAFAPVAHVRNTWTPTLRRYEDVGETILMFVDLAQGKKALGGSALAQAFGQLGDEAPDVRDVDSIIDYHDAIYQLHGAGIVLAYHDRSDGGLLTTITEMMFAGRCGAEIMLDGVSKSAALPDVLDALFNEELGAVFQVRKSDEINFIRCFATCGPPPGLVRKIGRVPAASKQKLVIRQGQQAILSMDRAELQQEWTKTSYWMQRERDNVDCADAEFENIKDDKDPGLSYKLSFDPKENILPLTATITSAFAKAPRVAILREQGVNGHAEMAFAFKTAGFDPVDVHMTDIMESRFHLASVVGIAACGGFSYGDVLDAGNGWAQSILLNEVARSEFQSFFARKDTFALGVCNGCQMLTRIAELIPGTNHWPLFIENASQQFEARFGMVKIQDNSKNPSVFFHGMNGSSLPIVVSHGEGRASFKNQQDLEALDADGLIPIRYIDNRGSVTSRYPYNPNGSPEGIAGVSSRDGRVLAMMPHPERTIMADVGSYIPQDLVEEWGEFGPWVRMFKSARRWIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S9H9</accession>
    <name>A0A3D8S9H9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04496</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S9H9"/>
    <dbReference type="OrthoDB" id="5218421at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW83005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="77" mass="8414" checksum="B2750D5A17BCB882" modified="2019-01-16" version="1">MSSAATSYPEAAGQHSSSFDMGHFDITSYARTMHQHTKKQMEAASKSARRRSPQTNTSQSTLSPQTSISSMESRSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SA78</accession>
    <name>A0A3D8SA78_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">ER membrane protein complex subunit 7 beta-sandwich domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_04674</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SA78"/>
    <dbReference type="OrthoDB" id="27095at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019008">
        <property type="entry name" value="Beta_sandwich_EMC7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039163">
        <property type="entry name" value="EMC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13605:SF4">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09430">
        <property type="entry name" value="EMC7_beta-sandw"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017547148" description="ER membrane protein complex subunit 7 beta-sandwich domain-containing protein" evidence="7">
        <location>
            <begin position="19"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 7 beta-sandwich" evidence="8">
        <location>
            <begin position="36"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW83183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="228" mass="24822" checksum="5B156FF9FFBCBE48" modified="2019-01-16" version="1">MQFSTIFVVLIATPLAVCSRLLVSLPSTAAFPNWNPSALTASTTASLTTISSTYTAPLRSDNTFDFRDVSPGSYLLDVHCSSHVFAPLRVDVSEAGQIESWGTFRGNEWDNKGEVVTVKNLGDLQNLDVKVLGEKSFYVERSGFSPLSLLKNPMILIAGFSMILVFGMPYLMDNMDPEMREEFEARQKTSPLTGGQAAANPLQNFDAAAWLAGSGPKKSELTEKSNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SA82</accession>
    <name>A0A3D8SA82_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative RAS small monomeric GTPase Rab6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_04760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SA82"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000611">
        <property type="entry name" value="RAB GTPase Vps21/Ypt51, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="205"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW83269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="245" mass="25774" checksum="D8BA674F651335F0" modified="2019-01-16" version="1">MADSTAAAPKPSSSVKLVLLGEAAVGKSSLVLRFVNNDFQENKEPTIGAAFLTQKCNLPTRTIKFEIWDTAGQERFASLAPMYYRNAQSALVVYDLTKPTSLIKAKHWVAELQRQASPGIVIALVGNKLDLTNETSEPADPLNDDGDADTTEGDDSSGDARKISTAEAKSYAEEEGLLFFETSAKLGTNVTEVFTAIANAIPETSLKGARGPGATQAGAGSGANDQSRVSLTGPRDNASKEGCAC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAA6</accession>
    <name>A0A3D8SAA6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutaminase A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_04778</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAA6"/>
    <dbReference type="OrthoDB" id="431715at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052743">
        <property type="entry name" value="Glutaminase_GtaA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032514">
        <property type="entry name" value="GtaA_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033433">
        <property type="entry name" value="GtaA_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987">
        <property type="entry name" value="GLUTAMINASE A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31987:SF12">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10910)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17168">
        <property type="entry name" value="DUF5127"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16335">
        <property type="entry name" value="GtaA_6_Hairpin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017709668" description="Glutaminase A" evidence="1">
        <location>
            <begin position="21"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A N-terminal" evidence="3">
        <location>
            <begin position="126"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="2">
        <location>
            <begin position="358"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="2">
        <location>
            <begin position="532"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="domain" description="Glutaminase A central" evidence="2">
        <location>
            <begin position="673"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW83287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="819" mass="91072" checksum="7D22035E5B9DCEF8" modified="2019-01-16" version="1">MRWTTCLTAAAAATAIAVEASTLTPPVLPLIVRNPYLSAWLGTARELPWDRWPIFWTGQEIGLGVLAAVPSSDVVYPLLGRPHDSLPKNGQEFNVSYPTYVGATFDASTTNLTYKLPAPNSSLDSAEVILSFLSPITPTSTLRQSIPASYLTVHVSGSFNVDIYIDMNGLWVSANRGNDIEWSFGPNEDPKDKKKALKTWKIQRRNQQLLTEDADRAEWGTLHFTGPADVQYEAGTSALLRQRFSKTGTLQNLIDRNFRKIMDEEPVFAFAKSFILNGSSSTGTNSFESALFTIAHIQDPVVQFASARGLTYMRPLWASYFQTADELLRYHYYDFENAFNLANNYSSQLAIDALKSGSEDYKDIVALSARQVLGATSFSGTPDDPIIFLKEISSNGNFQTVDVIFPAFPFFLYTNPRWLAYLLEPLIEYQLSGQYPNNYCIHDLGAHFPNATGHADGNDEYMPVEESGNFLIMALALTNALKYDTKPASIWQSMGDEGIHDQSLRAAFPLFTDSEGMDDSVGGPINGKGEKQARKWAERTYKLLKQWTVYLIQEGLIPKNQLSTDDFAGPLANMTNLALKGIIGIRAMSELAELVGEPEEAVYYRNISDVYVKKWQEPGGFGMARDGTHFKLAYSWYGSWSTLYNLFADSLLCFHLPSSSSLGAVVENQKPLVAEDASRTAFIDERVYKMQSDWYHSVRQKYGLPLDSRHLYTKTDWEFFAVAVASKSVREEIVQSIALWVNETTTDLPMTDLYDTEDPGWPGINFKARPVVGGSFAFLALERACEGKAVAGLSFLNEVSTPSVSQTNDAARQQGDGEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAA9</accession>
    <name>A0A3D8SAA9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glycoside hydrolase family 55 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_04737</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAA9"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23668">
        <property type="entry name" value="GH55_beta13glucanase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000023">
        <property type="entry name" value="Exo-beta-1,3-glucanase Exg0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.20.10:FF:000026">
        <property type="entry name" value="Exo-beta-1,3-glucanase Exg0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039279">
        <property type="entry name" value="QRT3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024535">
        <property type="entry name" value="RHGA/B-epi-like_pectate_lyase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928:SF2">
        <property type="entry name" value="PECTATE LYASE SUPERFAMILY PROTEIN DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33928">
        <property type="entry name" value="POLYGALACTURONASE QRT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12708">
        <property type="entry name" value="Pect-lyase_RHGA_epim"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017604941" evidence="2">
        <location>
            <begin position="22"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="3">
        <location>
            <begin position="59"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonase A/B/Epimerase-like pectate lyase" evidence="3">
        <location>
            <begin position="411"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="783"/>
            <end position="922"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="783"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="849"/>
            <end position="921"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW83246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="938" mass="97661" checksum="A2FFA2D03AF485E2" modified="2019-01-16" version="1">MASFSLLTLLVALRLLLLVSGAPAPQSSTAASTSSSSYWVSSITRQGTVAFGDSSFKIFRNVKDYGAVGDGSTDDTAAINKAITDGSRCGQGCDSSTVTPALVYFPPGTYAISAPLVQLYYTQFVGDAVTVPTIKALASFKGIAMIDANPYDNSGNNWYTNQNNFFRQVRNFVLDMTAMPASAGAGIHWQVAQATSLQNIVFNMRTDGGTANAQQGIFMDNGSGGFMTDLTFNGGKYGAFFGNQQFTTRNLTFNGCQTAIFMNWNWAWTLQGITINNANIGIDMANGGASAQTVGSVLLLDSTISNTPIGVSTVYTTSATSTNGTLIMENVDMSTNVPVAVADAGTKATILAGNAKVASWSQGRGYSAATVGKAVQASETAVTKPATLLNSAGRVYTRSKPQYETEAASAFISVKSNGAKGDGTTDDTAAIQAIFDKATNGSIVYFDHGAYLVTSTVKVPKDIKITGEMWPLIMAGGSTSFSDQANPKAVFQVGQPGDTGSVEMSDLVFETVGPQPGAILMEWNVKEASQGSAGMWDVHFRIGGSAGTQLQSDKCAKNPNVTAAANPSCEGAFMLLHVTNQSSIYLENNWFWVSDHELDLTDHNQINIFNGRGVLIASEAGPVWMYGTSSEHSVLYNYQISNAANVYMALIQTETPYYQSNPGATTPFTVNAAYNDPDFSKCTGTGCDKAWGLRIVGSKDVFVYGAGLYSFFDNYDQTCLETESCQENIMSIENSGSVYMFGLSTKASVNMLTVDGKSAALDSDNRNNFCATLAFFAEAGNGTTTQSTGSQPAGSQSSGTPSSSSQLAGSKSSSTPSSSSQPAGSKSSGTPASSPQLASSKSSGTPSSNPQLVASQSLGSQPAATKPTGSQSAGSQPAATKSSSSQPAATKSTGSQSADFQPAGSQPAATKSSATQLSITKSSAVQAVVTQTVYAQCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAB8</accession>
    <name>A0A3D8SAB8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA repair and recombination protein RAD54B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_04724</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAB8"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18004">
        <property type="entry name" value="DEXHc_RAD54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000035">
        <property type="entry name" value="DsDNA-dependent ATPase (Rad54b)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="312"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="637"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW83233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="946" mass="103813" checksum="81B2207CB27B11EF" modified="2019-01-16" version="1">MFKPFKPPAFKAAPNAAPVDLTISDEEKQTPPAKRRRLLVDVVEDSPPRKQTPTTFIGTSAPIKPLAIVKSSNADLPNQFSPPLEMSVGSEGYFMVLWRKFTNKKHKTWDGDGVLSVQGGYATLQDVSGRDMGRCRWNSPLLPGSTLSIGGKDVEIDDLIAKADFLAGKPFLKGAAKPAAAIGNAVNPKKISLPTPSLKTLLNKQKEAVDGGDNDSVEISAKSFYGSAFKSAATKAQFKNPLLSSTVLSQNKGGAPTPRHDPKIPGALVMQRPKDVPKGKQVVDVVVDPFINQHLRPHQKEGIKFLYECVMGMRSFNGQGAILADEMGLGKTLQTIALLWTLLKQNPIHGGSEGVIKKALIVCPVTLIVNWKKEFRKWLGNERIGVFVADSQKVRLTDFTHGKSYSVMIIGYEKLRSVQDELKKGSGIDIVVADEGHRLKTASNKSAQAIKALNTDRRIILSGTPIQNDLSEFYTMVDFVNPGLLGTYNTFKKEFDGPILKSRQPGASKKDLEKGNAREEELSSTTKQFILRRTAEVLEKYLPSKTEYVLFCKPTSAQAQLYQNVLKSPVFGTVLGSSEASLQLITILKKVCNAPSLLVRKANDAAPSNSNVAQLLESIPNEILKQSPLQASSKFRVLDRLLRHLSTNTSEKIVIVSNYTSTLDLLGNHVTALGLSFLRLDGSTPSAKRQEYVDTFNKTSASKNFAFLLSAKSGGVGLNLIGASRLILFDVDWNPATDLQAMARIHRDGQKKPVRIYRFLMSGGMDEKIYQRQVSKMGLADSVVDGKKNEASFSAEELRDLFRLNLDAGCQTHDLLGCDCKGLGTSNIESMTQDFGEGDGTDMENSDSDETFPDIRLIPASQYNAEKQDREMREYASKRKGKGRMQALMQYCHIDTSAFLGETTDVFGHDVDGVADLKRSIDDEILIKVLGDKVCKIGYIFARKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAQ3</accession>
    <name>A0A3D8SAQ3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 6">6-phosphogluconolactonase</fullName>
            <shortName evidence="6">6PGL</shortName>
            <ecNumber evidence="4 6">3.1.1.31</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_04867</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 6">
            <text>6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12556"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57955"/>
            <dbReference type="ChEBI" id="CHEBI:58759"/>
            <dbReference type="EC" id="3.1.1.31"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 6">Carbohydrate degradation; pentose phosphate pathway; D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage): step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 6">Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.31" evidence="4 6"/>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAQ3"/>
    <dbReference type="OrthoDB" id="432544at2759"/>
    <dbReference type="UniPathway" id="UPA00115">
        <property type="reaction ID" value="UER00409"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017057">
        <property type="term" value="F:6-phosphogluconolactonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006098">
        <property type="term" value="P:pentose-phosphate shunt"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd01400">
        <property type="entry name" value="6PGL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1360:FF:000005">
        <property type="entry name" value="6-phosphogluconolactonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005900">
        <property type="entry name" value="6-phosphogluconolactonase_DevB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039104">
        <property type="entry name" value="6PGL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006148">
        <property type="entry name" value="Glc/Gal-6P_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01198">
        <property type="entry name" value="pgl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11054:SF0">
        <property type="entry name" value="6-PHOSPHOGLUCONOLACTONASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01182">
        <property type="entry name" value="Glucosamine_iso"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucosamine/galactosamine-6-phosphate isomerase" evidence="7">
        <location>
            <begin position="14"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW83376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="260" mass="28152" checksum="9E44566597FEF359" modified="2019-01-16" version="1">MGKQPNLFAFPAIDALASTLRTYIIQCQNAGINRHDAFKVAVSGGSLPKTLAQALLAPPTSPEDTIKFDKWEIFFADERAVPLDHEDSNYALLKSELLDKIPAEMGKPAVHPIDTTHLDDVQELADQYEQLLVRSFASRDSVKLPIFDLLLLGCGPDGHTCSLFPGHALLRETDAWVAPIEDSPKPPPKRITLSLPVVTHGVKVAFVATGGGKKEIMKKIFEEGAGLPCALVNEGAGERCSWFVDNAAVEGVSFPRKGSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SGZ0</accession>
    <name>A0A3D8SGZ0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03888</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SGZ0"/>
    <dbReference type="OrthoDB" id="2590756at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW85563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="137" mass="14769" checksum="A0103443B87C74A5" modified="2019-01-16" version="1">MARSQPLSSRSMLPFYLHLFLETPAALNFFFNPGQQLGLSESVPQAEAVVRQYAVLLLSSNLVALAMICRPSDGTTQRVSGALGIYHVAPLVRAVGKIWAGQVSLSSGLGGPWVHAFGHAIALFLLLSLYLKPIIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SH32</accession>
    <name>A0A3D8SH32_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Molybdate-anion transporter</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Major facilitator superfamily domain-containing protein 5</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Molybdate transporter 2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_03984</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mediates high-affinity intracellular uptake of the rare oligo-element molybdenum.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SH32"/>
    <dbReference type="OrthoDB" id="263957at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015098">
        <property type="term" value="F:molybdate ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006811">
        <property type="term" value="P:monoatomic ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17487">
        <property type="entry name" value="MFS_MFSD5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008509">
        <property type="entry name" value="MOT2/MFSD5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23516:SF1">
        <property type="entry name" value="MOLYBDATE-ANION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23516">
        <property type="entry name" value="SAM (S-ADENOSYL METHIONINE) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05631">
        <property type="entry name" value="MFS_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="119"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="267"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="308"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="428"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW85659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="456" mass="50510" checksum="0762041FA4AC2975" modified="2019-01-16" version="1">MDFYASAFVLLISACGLLTWRQYRTSEETAEQKGLTQQDAYSPSQKAEAKKFSKLFLTVYCLVMASDWLQGPYVYSLYKDQFELQETVVAALFTTGFVSAGISGYYVGHFADKFGRKTACLLFCVTYAISCFSTLIPSLPVLFIGRVFGGISTSLMYSAVESWMVTEYHKRQLEKSGTSLSSMFGIMTMLNSIVAILSGVFSEWLVRITSTRRSPFMASAALLIISFMIISRTWTENYGDSGNASETSNPTVPAKNVIKMVFTDQRILTLGLASCFFEGSMYLFVFFWTPALKAARSQASTNGDHHAAGLPLGMIFACFMASVMLGSLLFNLLVSKYRIISHSRLLTIIFATASSSLLVTVVVKDETLTFWSFCVFEACVGMYWPSVGYLKGLVIDDSVRARVYGLMRIPLNIFVVVALSLIQEGEAYRNQVFMTCSGLLVVVSGIFHYVVTESVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHQ8</accession>
    <name>A0A3D8SHQ8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Flavin reductase like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_04210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the flavoredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHQ8"/>
    <dbReference type="OrthoDB" id="10250990at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002563">
        <property type="entry name" value="Flavin_Rdtase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052174">
        <property type="entry name" value="Flavoredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43567:SF1">
        <property type="entry name" value="FLAVOREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43567">
        <property type="entry name" value="FLAVOREDOXIN-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01613">
        <property type="entry name" value="Flavin_Reduct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavin reductase like" evidence="4">
        <location>
            <begin position="15"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW85885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="217" mass="24220" checksum="554B16257EDF9CDC" modified="2019-01-16" version="1">MPHSPINPAILYWGTPVVLITTTNEDSTSNISPISSAFWLGDHCMLGLAAYSQTVINLQRTKQCVLNLPSDDMTAAINALACTTGTKDVPSGKAQRGYRYEKDKFSVAGLTEQASERVAPPRIQECPAQMEAEVVGIYEMMRDGPESISGSLLAIEVKVLRTYVEDRLRLRGYENRVDPLAWRPMIMSFQHLFGLKEGKPEESTLARIEEELYRLPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SIC0</accession>
    <name>A0A3D8SIC0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_04358</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW86033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SIC0"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017497428" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="18"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="33"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW86033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="524" mass="56298" checksum="A2A2A08EC209AEF0" modified="2019-01-16" version="1">MQFFTVFTALSLPLAWAAPHFQHKRSNFTIGQIIVTSSGPVAGHAPTTHSEVSEYLGIPYAQPPVGDLRFAAPLKFDGRSMLNGSAFGNSCPVMQSSGSAPTDAQIAFSNITDVGLELITTILSPTVVHSEDCLYLNIWTKPQSGERLKAVMVYIYGGGFTGGTSSIPVFDGATLADEEDLVIVTFNYRLSILGWPGNPTAQNNVAFLDQRLAMEWVRDNIAGFGGDSTRITLFGQSAGAASIDFYSYAWSSDPIAAGIILQSGTTGLYPANSEIVSAAAWYNTSDALGCGNALTDSVTLLECMRNVDVDNLLEAIPRTGVNAIVSAFGPTIDNALVFSDYSKQTPANIPVLVGNNDYESGLFRTQLALSGTAFPEWVWSAYDLAGYTCPSGVRANASILASNPTWRYRYFGVYPNINISSEGGAWHGAELQLIFGTTYLTGNDTVKEFALKKYLQGAWTTFAKDPVNGLTTYEGGWPLYNPAEETLIRLGYNNVVGKHLASPKLYDTECTNATITALEASFFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SLK1</accession>
    <name>A0A3D8SLK1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_02913</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SLK1"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050654">
        <property type="entry name" value="AChE-related_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918">
        <property type="entry name" value="ACETYLCHOLINESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43918:SF4">
        <property type="entry name" value="CARBOXYLIC ESTER HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="41"/>
            <end position="559"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW87219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="570" mass="62606" checksum="41C3205C05172DF3" modified="2019-01-16" version="1">MGVLKVVQVYLSGLLAASSFHPALNTLPQPIVFVANQSFTGIIINSTLTGHPLPVPVNALLGIDYASQPVGEDRFKPVRPLILGNWSGGIDASRYGKVCIQDPRFISYEQDEACLNMNIYWSITEARKEKLPVLVWIHGGGFVSGSGRSFDGASFVGTSKSPLMVVTFNYRLNSLGFLPSGMFEKEGLLNLGLLDQLQLLEFVQEHISSFGGDPENVTLGGRSAGAHSVGIHYFHNYTTGSTEAKSGKALFSKAILQSGSVTARSFPGATYPLYEAQFAKYLSLIGCAGLHGVPETLQCLRTVDISIIRDASTQLFQESEYAITWPFQPTLGGPLFEMPGSISGAQGMFYRLPVITTTVNDEAKLYTPGNLTSNEQFLEFMHNLTPYLNTTDMELLETLYPDPLTSSDGTPPYSDSPNSTQYNRLSAAVSDYMYICPSQETAVRTSSAGVPTWKLRFNTNNSFPAWQGIPHTADTRYTWNAPAEELQFPQIGSILHGYFSSFVVTGDPSQLRILEDTLQSPEWPSYISNGDEIGRQLVLEPGSARIEDDMIRKEQCAFWRDLERSGRLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SM90</accession>
    <name>A0A3D8SM90_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 16</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_02995</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the biogenesis of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NOP16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SM90"/>
    <dbReference type="OrthoDB" id="285729at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019002">
        <property type="entry name" value="Ribosome_biogenesis_Nop16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243">
        <property type="entry name" value="HSPC111 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13243:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09420">
        <property type="entry name" value="Nop16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="32"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="155"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="173"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="189"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015522"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW87301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="272" mass="30532" checksum="CAB85B8DC267F268" modified="2019-01-16" version="1">MEARISGGPGSSETSGRAIKNVIEDFQISAGAIASKPNNQDNATMGRELQKKKNRSSIAKVRMKPKSKRVNPLGNPIIAANWNQDETLTQNYRRLGLTSRLNAATGGIEKLPSGKDAHTKSSTINKLAIENAFPTTIAPTEAKVERDPETGKILRVIHSKSRPNPLNDPLNSDSEEEDKEYEDFDGFEGEEKPKENEIVKRLEELASREAPKKERTQSDREREWIERLVRTHGDDYGRMFRDRKLNPMQQTEADIKRRVAKWRAKGGSAVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMD9</accession>
    <name>A0A3D8SMD9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Apple domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03045</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SMD9"/>
    <dbReference type="OrthoDB" id="3499003at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW87351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="227" mass="23990" checksum="2301455B57DF3520" modified="2019-01-16" version="1">MDGRLGRSYRNSANAPEVVDLQIDPFVNNADTQKSPFGPPIPYQYSQSTTSRLMYGIPRVVIYVVVVFMCLVLGGVIGGSIGRALFHKSNRSTMSVVTTTNSTSGPSKITSTMLPTITVNAAGCSANNGSTYASSAYPGSNFVILCDTDIQATTNIGPGQLTYTLEACLDECARNNDNATRTYPCIGAIWVLSSPIVPTNNMQCFLKALSGTQVSAKGQILAGGLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMK0</accession>
    <name>A0A3D8SMK0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative autophagy protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03196</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SMK0"/>
    <dbReference type="OrthoDB" id="2103031at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW87502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="314" mass="35528" checksum="E173DFB50446752D" modified="2019-01-16" version="1">MGWFWGSSDDKGSSSSQDPLRNLDPSLRDFLAKESPVKYSTSTPQTPEAVATPAQPAAKVPQTAQSQPGNDAEPKVPKESLYQDGRYADLWKTYVPQQQVEAAMKSESEKVNDVIEAFKERKARIGIAAMENCVLEQIDVEECFQNGGWHARLTMCKDEKRKVDRCFTMQGKFLRALGYLSTYDRSPEEEERIQMHADTLYHRMLEQEKEIEAAKAEGKPIPQFAPLLSRPKPAADGLQMSAKSQAQLKERLKSMKPEERELEEAAAKAELDSGREIAGSLGKIYQQQDEERRQRREAGSETIGDRIISIIRWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SML5</accession>
    <name>A0A3D8SML5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative J-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_03118</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SML5"/>
    <dbReference type="OrthoDB" id="552049at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016558">
        <property type="term" value="P:protein import into peroxisome matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000028">
        <property type="entry name" value="DnaJ domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026894">
        <property type="entry name" value="DnaJ_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052814">
        <property type="entry name" value="Peroxisomal_DnaJ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45006">
        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45006:SF1">
        <property type="entry name" value="DNAJ-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14308">
        <property type="entry name" value="DnaJ-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="121"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="466"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="148"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="466"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW87424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="502" mass="55168" checksum="A2A0E2442447478E" modified="2019-01-16" version="1">MVVDTTYYDALGVKPDATELEIKKAYRKLAIITHPDKNPGDDTAHAKFQAIGEAYQILSNTDLRRQYDKYGKDQAMPSDGFADPAEFFGTIFGGEAFVDLIGEISLMKDLTKTMDITMQEGEAEEGEEFPGEAAAKAESLEAEKAKTTAEGSSAATPPAPSVAEAADTKSTTAPAAAAEKPAAAPSSKNGSGTSTPRPQGIPIRAAIMDKSEEDARLNAAGLTEEEKELKRKEKKKGGLSKAQREELAAYEKERARIRQERVDTLARKLIDRISVWTETDKGPDVTHAFQEKTRLEVENLKMESFGLDILHAIGTTYLQKATALLKSQKFLGIGGFFSRLKDKGTLAKETWNTISSAIDAQMTMEEMAKMEEKGGEDWTDEKKVEYERRVTGKILTAAWRGSKFEIQGVLRDVCDEILNDKKVPMSKRLERAQALVICGEIFQKAQRNPEEEGDYMAFEQLVAEAAAKKEKDTKKKGKDKKDKTAEQTAHDVAADAPNVPKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMM4</accession>
    <name>A0A3D8SMM4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_03128</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UPF0057 (PMP3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SMM4"/>
    <dbReference type="OrthoDB" id="2802411at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000612">
        <property type="entry name" value="PMP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659">
        <property type="entry name" value="HYDROPHOBIC PROTEIN RCI2 LOW TEMPERATURE AND SALT RESPONSIVE PROTEIN LTI6 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21659:SF112">
        <property type="entry name" value="PROTEIN SNA2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01679">
        <property type="entry name" value="Pmp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01309">
        <property type="entry name" value="UPF0057"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009530"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW87434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="97" mass="10641" checksum="3E060AF55291ED9F" modified="2019-01-16" version="1">MAPSSTFDTLDYLLAIFIPPIAVFLKTGCNADFLINICLTVLGWIPGVILVWKDMCIVHFVLRSVGGFGQGKKREGSADKNSDAWYVIGKHDPAKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SN58</accession>
    <name>A0A3D8SN58_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_03457</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SN58"/>
    <dbReference type="OrthoDB" id="5550281at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF5">
        <property type="entry name" value="BOX PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G04550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="119"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="119"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="95"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="232"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="306"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW87763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="333" mass="35763" checksum="2490425FC7890F29" modified="2019-01-16" version="1">MSSTTKKTKKTGEGSTQGATLSIDVDSFVRTRDSVVTGLATLQDAIQTLSTAYIKHTNAVLGEHGAGLDPGVEHALSKLSDNPLLGGIAGLNRAASPAKVDAPEEKKERKKRQHDPNAPKRPLTPFFLYMQTARPIIATDLGADVAKGAVSAEGTRRWKEMAEADKQLWSNAYKDNLRLYNARSHSYKAGNLDAKDMSNEEALVYADDHNIDASTADPSAQLLAENPVVVEDEDAEGEVEVPVPEPEPTPKTPKAKGRKGKATKEVEPESAKAVTESAVLPPSAAKPTPDKKRKRTSTAKAAPVESIEKEEAPVETPKEKTKKSRSKKAKNDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYF2</accession>
    <name>A0A3D8SYF2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">NEDD8-conjugating enzyme UBC12</fullName>
            <ecNumber evidence="11">2.3.2.34</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">E2 ubiquitin-conjugating enzyme 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="12">NEDD8-conjugating enzyme Ubc12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">RUB1-conjugating enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Ubiquitin carrier protein 12</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein UBC2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme E2 2</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ubiquitin-protein ligase UBC2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BP5796_02522</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine + [E2 NEDD8-conjugating enzyme]-L-cysteine = [E1 NEDD8-activating enzyme]-L-cysteine + [E2 NEDD8-conjugating enzyme]-S-[NEDD8-protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="2.3.2.34"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="17">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.34" evidence="11"/>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYF2"/>
    <dbReference type="OrthoDB" id="10249039at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061654">
        <property type="term" value="F:NEDD8 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23794">
        <property type="entry name" value="UBCc_UBE2F_UBE2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000005">
        <property type="entry name" value="NEDD8-conjugating enzyme Ubc12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 17" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="19">
        <location>
            <begin position="31"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="16">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00041569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00043698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RDW91357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="186" mass="20999" checksum="803DA0622C8BF5B6" modified="2019-01-16" version="1">MLKIWSMKQKQQQAANADAAATGIKKKKVTAAQLRVQKDVSELSLPSTMKTEFPDEDDLLNFTLTIEPDEGMYKGGRFHFKFEISQDFPHQAPKVKCTQKIYHPNIDLEGNVCLNILREDWKPVLNLQSVMIGLQFLFLEPNASDPLNKDAAEDLRSNREGFKRNVRSAMGGGAVKSQSFDRVLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYX9</accession>
    <name>A0A3D8SYX9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_02680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYX9"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW91515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="58" mass="6092" checksum="9FC02AEEC3F52F2F" modified="2019-01-16" version="1">MLAVDSFVELVRKLMIVVVVATVEPDPDTGEEAAAGRVDNAASAVYDAESPVTFLQAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZ15</accession>
    <name>A0A3D8SZ15_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02732</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZ15"/>
    <dbReference type="OrthoDB" id="3923593at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017612869" evidence="1">
        <location>
            <begin position="20"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="372" mass="35617" checksum="DAEBEBB9887685F9" modified="2019-01-16" version="1">MQFSIASMALFAASALAIAHPEHQQFHHRRQLNSTAEHTTLTVKATITHTITSCAASITNCPARAAESTSEMVVTETIDLTTTVCPVTAAEAASSAASASYFATATNVGAVAVTPTASIPLSTGASASASEAGAAGASSSPVVPLGTGVSAAASSASPVVAAVGTAVTVSNSTLTYTLGSGSSTTVITTTVQHTSTATSYTTEYVTATPAASAAEGVGASASSTGPTTTLTGTSTMTKTLTVVPASSGAAGAAASDLSGVNAVATGSAAASGACAAVTVTETIALSTTTIYASMTASGAAAVVTDLAVAAASSSSSAVVIVSTATVQPLALSSSVAPYGNGTVATSTKKKCSSIFPSGFITKTGGLAVPTGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZ94</accession>
    <name>A0A3D8SZ94_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aminopeptidase</fullName>
            <ecNumber evidence="11">3.4.11.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BP5796_02800</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9 11">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9 11">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.-" evidence="11"/>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZ94"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042277">
        <property type="term" value="F:peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09601">
        <property type="entry name" value="M1_APN-Q_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.390.10:FF:000001">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1730:FF:000002">
        <property type="entry name" value="Aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024571">
        <property type="entry name" value="ERAP1-like_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034016">
        <property type="entry name" value="M1_APN-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050344">
        <property type="entry name" value="Peptidase_M1_aminopeptidases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533">
        <property type="entry name" value="PROTEASE M1 ZINC METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11533:SF174">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11838">
        <property type="entry name" value="ERAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 11" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 9 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 11" id="KW-0645">Protease</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="14">
        <location>
            <begin position="28"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="12">
        <location>
            <begin position="253"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="ERAP1-like C-terminal" evidence="13">
        <location>
            <begin position="540"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="325"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="10">
        <location>
            <position position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR634016-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF11838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDW91635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="883" mass="99354" checksum="AE5BCDFCE7E9A6D6" modified="2019-01-16" version="1">MPVGLSSRRRGWGTKVSERELLPKNVRPVRYELCLEPDLEESFDFVGTVVIDLYVVQETSSITLHSLDLEILETDVFAVDGTTIDVKSLTFNKSKETVTVHLTKSIRAPAKLQLRHKFTGSLVDHHGAGFFRSPIQESGVVRWMASTQFEPTSARKTFPCFDEPALKARFDITLVAQRHLTCLSNMPVTKAHEIEAPSTGKKMKKVTFATTPPMSTYLACFAVGELNFIETNAFRIPVRVYAAKDKNIEHGRYSLDLAAKTLEHFEKTFDVPFPLPKMDLIAIPGGQGGMENWGLITFADYFLLLDPQNTAAQSWQRIASMVVHELAHQWFGNIVTMEFWDALWLNEGFATWAEIHAWQSLDPMWPTWQIFTVDQYQDALNMDSDLATHPIEVPVKRAGDITQIFDAISYNKGCAILRMLSDLLGESVFLKGVSLHLKRHSFGNARTTDLWDALSAVSGKDVQSMMEVWTRDPGYPVLQVVEDAANGSITIAQNRFFQAEKAQKGTELLYPLALKVRHENGISRKQLSSRKTQIKMPLGFYKVNADQSGFYRVAYSSERFLMLAQNARDDLLSAEDRIGLVSDALALAFNGSYQVTTSTLLALLERFDEETSFAVWKQVINVLSTILEAWSYESDQTITMLRAFKTRLVSKALARNGWEFGDGDKWVDQMLKARLFAAATNELISNEAAERMFKAYSNGDKSAINLNILEAVFARVLGNDPTQEKYDTILEGCQDVSDINRRQICLKSLGYAQTNALMSQTLELAIKPEIVTRGEMLQVIEPLTGHGVGKAKVWEWFKANIKPILQAGGGAPGSSGRVISLCTANLCSREQWQDVRDFFQHQNTEQYKTYLEISLNAIHGRAVWVERDRDEVHAWLMKNGYGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZF8</accession>
    <name>A0A3D8SZF8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02716</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZF8"/>
    <dbReference type="OrthoDB" id="5428890at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="354" mass="40625" checksum="6978C9468500B9EC" modified="2019-01-16" version="1">MNNIATGDALEHGLETLLLTTKSRSEFSRSLMRVDVPAKIFQSPNLDSYFRYYLEQCTTAVIDTSDQTKTHRQIVNTARLLADPSTDASYISNLLERATTSDEENDEVYWTFFAVRVLTMIDVGGLRQGIRLGLSPNIWSEGTIRDFVKAKFPAEKVLFSNGKMDPLFNACNIDSIASIRVIWTNNIADHLILEDGDRSIKVFSHVSFLELHRDCDIFPPGFVDETIRTLALLLPSNDKETRIWFYKEQKRCSNQSSIDSKAIDCRPVNSINRQFQKYNFWHDRLVMLNEAFNDPNPKSMRQLWLDRRRPAEWYSFWYAIFLIVGLTLFFGLVGSIEGGLQVYKAYHPSSSQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T049</accession>
    <name>A0A3D8T049_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cyclin-dependent kinase</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_01337</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T049"/>
    <dbReference type="OrthoDB" id="413582at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001300">
        <property type="entry name" value="Serine/threonine-protein kinase csk1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF576">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CSK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="91"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW91943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="385" mass="42459" checksum="96C42B90CBCE8077" modified="2019-01-16" version="1">MSSAPDWRKSLGAVERYENIQKLKKSIAIHGLSATGTAHKVAVQREAEAYNTSQSKEAYEAACTAVESREPTSLSGQIPIPGTPGMSIGNYLDCHHVASGMVSEVYRSGSRALKVITETVNVEPHNPGREAKILRELSHSSIIKLIETSKDHGGRLILVYPFMPLTLARIILTGSLSPKTLRSCFRDLFSGLAYLHEKGIIHRDVKPSNLLLESPTGPAYLADFGTAWHPEYSVHDEPADQKVLEVGTTCYRAPETLFGNRSYGPSLDIWASGVMLAECIRKPHEPLFESRETSEDGNQLGLILSMFKTLGTPTKESWPEAKGFSTPPFDWYQEFPGKSWDELLPGVDTKAKDLVAGMVRYESGSRLTAKQLLETSFFDEENVST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0Z3</accession>
    <name>A0A3D8T0Z3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_01563</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0Z3"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF52">
        <property type="entry name" value="SINGLE-STRANDED DNA-DEPENDENT ATPASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="461"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="834"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="943"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="498"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="913"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW92169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1120" mass="125085" checksum="8E71C0C0B5DF6395" modified="2019-01-16" version="1">MASWNQYNGSPPSNNHPNANGGTAQPYSTPTWNAAALLNPRGFQQPAPQPRDEPKVGGFAQYSNSPGLSFQFDSPGGSPAPAQYQSLPPSNGSASNDYSIVYNDGSVQMNGMGQMLERMHNVEDRSMLPQKRRKIHNDGHDDARTPGFTGGGKGGVLGQYMKEKKEEGRKEIIAKGTSVDLSVDDEPDVVIVGDSGDKEVCYGRIEGAEINAFKVPTPKPGAVAMSNNYWPQVKIVLRRRVGDKTTVIHAVDSTRSVIGCVDVNTAIGICPILDSKYNIRTSCRILTRPKRQDDLPPGADTSTRYGLDLNMYGPKKYAIPIGKHLSQKQLWLRTPLFMEAGIELYNPHTILKIQQPARTPASSGYRSQGPVRTVEEIRNEVIGMFDTLEVSENLPVMDPDPRITTELLRHQKQGLYFMINKERVRGYGPDEKGNNCSLWKLQFGNNGQRTYYNVITGQEVRQPPPQLRGGILADVMGLGKTLSILSLVVTTLDESSQWAMKQPGDTQDQRVEKPQSKSGKPSTVPKVDQASLVLNSKATLLVCPLSTIANWEEQIKQHIEPGTLNYYIYHGAGRIKDVHKLAEFDLVITTYGSVASEFNYRSKNKQGKVLPLEEINWFRIVLDEAHMIREQATQQSKAICRLSAQRRWAVTGTPVQNRLDDLGALMTFLRIKPFDEKGGFAQYIMAPFKMCDPEILPKLRLLVDSITLRRLKDKIDLPKRHDHLVKLDFNSEERRLYEIFAKNASDRVKVIVGQREKSLGGRSYVHILQSILRLRLICAHGKDLLSEEDLKVMHGLSKDSAIDLDDEDEDGPALTARQAYDMYKLMKETNADVCLTCSGKIGPREVVDSDGEPKDEIIGHMTPCFHILCPGCIVRYKATLEEVAQGKSQLDCPICKQFIRLCYFPLRQGGIEDEEDSSESQSNSRHGKRLGVYNGPHTKTKALIDDLLRSKEESESKPFEPPIKSVVFSGWTAHLDLIQTALEQNSITFTRLDGKMSRASRGAALDCFRDDPSIHVILVSITAGGLGLNLTTANKVYVMEPQYNPAAEAQAVDRVHRLGQKREVETVRYIMNDSFEEKMLELQEKKKKLASLSMDSSGKQSMDKNEAARKRLEDLRSLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T120</accession>
    <name>A0A3D8T120_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_01666</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T120"/>
    <dbReference type="OrthoDB" id="2985014at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd14688">
        <property type="entry name" value="bZIP_YAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012">
        <property type="entry name" value="B-ZIP TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37012:SF2">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="118"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="70"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW92272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="495" mass="54831" checksum="E6F3AB2DE243C1A0" modified="2019-01-16" version="1">MSDNNSNSNSNTESTSEGDNSDVHRLGGRPAKAGAKRRASRAGTRSVATLSEAQLARKRANDREAQRLIRRRTKDHIEQLERRIRSLSEGQGTTGELEELRRRNTELETELSMLRGPRSLSEEGVVGQDGKRINQGSLPRRPSAPTSYPSSYIATNESMSTSRYSTPDSLWPPWPASYSHPFVAESLAGTSSSNASLTSAYSSYESPSMLSSVVGSPIGMVSPIAPPRSDPGLVDVSDESWLPMNDSRMMPIPILSDASQPNLGSTNDHSTPSWELPIRTLPPTGPIDNIIISLVQQQQNKIVNGDDVLSTIGPHQPSMNAIVYSDQTATSHHISTILSDVLKNTALQRIPERAAALHFLYRLVQWQIYPSKSTYDQLLDWQIPRTTQIITPHPAWADYIAWPKLRDEVICNLATYGSEDFQHVYTSSLNVNWHWRDTDAFVIENDGQVVLSMEFESHISNLANWSLDAPFARKYPELGRLCKFTEGESGGQSCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T129</accession>
    <name>A0A3D8T129_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS transporter-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_01638</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Vesicular transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T129"/>
    <dbReference type="OrthoDB" id="5086884at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17325">
        <property type="entry name" value="MFS_MdtG_SLC18_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050930">
        <property type="entry name" value="MFS_Vesicular_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001958">
        <property type="entry name" value="Tet-R_TetA/multi-R_MdtG-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23506:SF23">
        <property type="entry name" value="GH10249P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01035">
        <property type="entry name" value="TCRTETA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="328"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="364"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="434"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="34"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW92244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="505" mass="53137" checksum="E4FD728A222F75B7" modified="2019-01-16" version="1">MFTKDGVYTFIHGTRIGNAAAPPLLKFRSSHSFIIGTIATAVFTDIFLYSLVVPVLPFALTARAGVPEGEVQKWTSVFLSVYGAALAVASPTLGWLADRSTSRRMPLIVGLLALAAATAMLCIGTSLAVLIAGRILQGVSAAVVWTVGLALLSDTVEKEEIGQAMGYIAAATSIGSLAGPLLGGVVYARAGYYAVFAMGFALIGLDVFLRLMMIEKSVAAQWAVPDAAAAAAAESRSEALPTSSVLEARSARGSGDVHSAGDMQEKAIVRTPSLREDPAPKAFSQRLPPMIRLLRIPRLLASLLGCFVQSSSLAAFDSVLPLYVKDTFHWTSTGAGLIFICLVIPSLFGPVVGFLSDRYGPRPFTTLGLVGAIPFWVCLRFVDHESMAQKVLLCALLSLIGVCLTLSMTPLMAEIDHVLEEEERKNPGGFGKKGAAAQGFGLFNTSYAVGSLIGPLWAGFIVAGPGWGTMVWTFAVLSGVIGIATFIWTGGRIVLKGGESSESEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1J0</accession>
    <name>A0A3D8T1J0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_01763</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1J0"/>
    <dbReference type="OrthoDB" id="20368at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11296">
        <property type="entry name" value="O-FucT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="2" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW92369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="456" mass="51954" checksum="DD42EBF3D9F386D0" modified="2019-01-16" version="1">MGITPRNLPFKLAIALVSFVSIVYFFFFRSDNTYQQRLESIYTSAGNTYGSAVKGKQATFVKNFFESEIDGPINLEPIKFVCDGKRWNTSIIVQCELPHGGIASVRNTFLNCVRYTIEIGGAFMLPQVVNRDVTPKHMVPEIAQDMSYFFDKEHFIDSMTKACPQMRIYRSMDELWNVPTTQKAYEIQPEALTKDFAPPGVLKKPEAWRDLFKSWLQVAVKFTPTDDKPIIVKLKQPFLQFPLRYDRGEFVMSFGRILRFREDARFIAANVLYALGEHFNIDLDPTKSIRPQKFYGAHLRNEDDAATPVKEQINSVVKVATEMSLKNLYFSAMASENTTAFVTKAASQNISLACKESLLMEPGYEPIKLELAKLTWDQQAMVDYEVFLRSSFFSGVKESVFAWNIAMRRHIANGEGTWMTGEAMKPKGGPLSFLDKLSIILGTESDWGRVLESLWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T237</accession>
    <name>A0A3D8T237_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pal1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_01963</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T237"/>
    <dbReference type="OrthoDB" id="5352132at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013226">
        <property type="entry name" value="Pal1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28307:SF2">
        <property type="entry name" value="PROTEIN PAL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08316">
        <property type="entry name" value="Pal1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="460"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW92569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="526" mass="56985" checksum="59749A646EB951DA" modified="2019-01-16" version="1">MSVAQPDSGESRLSPGLSLNLSSNNPFRNRAASPALSSNSNQRSPLEAPPRPVSRNPFLDATPVNHLPQSTFGSPDKMAFGTDTKEPPRSALTGNAADLFDNLTLDDKPSSSGMRPAPKNENVRPRGPPSHRPSRSQEEAMRARRREAAGGSSRPRPSKDELNIFADPSDSPKKDASRRPRRNSDSSVALDEDEKKRQERRRRERERRHADRAKAQGKRPKNLDVIDKLDVTSIYGKGIFHHDGPFDACNPHRNRKGSQRAPMSAFAKDSLNNSLGGSGPLNKRPDHATFMGNNDDEAFLDYAKGGADGYGYESYANGAIRPEGSQRAESHVIDALTRVEPVHGDESLGLGTSTFLEGAPASRTAMQRRESETGNEGGLSRKKSLAQKIRGISNNRRDYGPSGRITSPEGVYNPTSPEGAYTPSGHKSTESNPFAAEFSGKDKAETTIKITEPERRPGGRARAPSSPRRGFAEGGLQRRQTSDGGSTAEPPAPKTGGGFLSRVKSLKGGPRKTRPERPQIPAQPEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T2K9</accession>
    <name>A0A3D8T2K9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">galacturonan 1,4-alpha-galacturonidase</fullName>
            <ecNumber evidence="13">3.2.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BP5796_02065</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-alpha-D-galacturonosyl](n) + H2O = alpha-D-galacturonate + [(1-&gt;4)-alpha-D-galacturonosyl](n-1)</text>
            <dbReference type="Rhea" id="RHEA:14117"/>
            <dbReference type="Rhea" id="RHEA-COMP:14570"/>
            <dbReference type="Rhea" id="RHEA-COMP:14572"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:58658"/>
            <dbReference type="ChEBI" id="CHEBI:140523"/>
            <dbReference type="EC" id="3.2.1.67"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the glycosyl hydrolase 28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.67" evidence="13"/>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T2K9"/>
    <dbReference type="OrthoDB" id="187139at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047911">
        <property type="term" value="F:galacturan 1,4-alpha-galacturonidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004650">
        <property type="term" value="F:polygalacturonase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071555">
        <property type="term" value="P:cell wall organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.10">
        <property type="entry name" value="Single-stranded right-handed beta-helix, Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000743">
        <property type="entry name" value="Glyco_hydro_28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012334">
        <property type="entry name" value="Pectin_lyas_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011050">
        <property type="entry name" value="Pectin_lyase_fold/virulence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31736:SF12">
        <property type="entry name" value="EXO-POLYGALACTURONASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00295">
        <property type="entry name" value="Glyco_hydro_28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51126">
        <property type="entry name" value="Pectin lyase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="10" id="KW-0961">Cell wall biogenesis/degradation</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="4 16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017800328" description="galacturonan 1,4-alpha-galacturonidase" evidence="16">
        <location>
            <begin position="25"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU361169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDW92671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="485" mass="51451" checksum="9F4F1A92F7FDFA3F" modified="2019-01-16" version="1">MKSSTSTLATFALAAAALAKTVGASTVTPAPAVRHARNVSTYHPDFATRTVSVPQLTLPLTAATDYVLGGSVSSRTAPSPASVVPVCTVIPHGWGRDDAQQILAAVEACGTDGEITLPAPYVYTIASRLYMKLVRAKLNIFGTLSFTPDIGYWINNSHRVEFQNQSAAWVVEGEDFVISGGAWAQGGVEGNGQVWYGRAAGQSNQYGRPMPLAIYNSTNATVQDFSFNQPQFWTFWVQDSYDVSLTGIHINGTNTDPYGNGSNWETNIDGIDSMRVNGLTLEDWEFHGGDDCFAPKGNSTNMVLRNITCVGGGIAFGSIGQYPESPDYIANVTATDISVTQKISSVYGGATVNGGAYFKSWVGVEEGTPPQGGGGGTGRVWNVTFENLQVDGVKQAVYINKCYYKVADQANYCDTSTLLFEELTFSNVTGVVSSDYGVSFNCSAAAPCQDLAVSDLSLTMSNGIESGVYCDNVESLTGVNCTGGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T862</accession>
    <name>A0A3D8T862_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4 14">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BP5796_00467</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 14">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4 14"/>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T862"/>
    <dbReference type="OrthoDB" id="46988at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF3">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11 14" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7 14" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5 14" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9 14" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="189"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDW94704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="226" mass="25668" checksum="3A55B345A73DD8DC" modified="2019-01-16" version="1">MDATTDRKPVPQQRPLKPLRSNSPKTQYLIIYNFASAVLWTAVLGRVLLLVPLVGFGQAYQGVGTFTKWTQTMALLEVVHAATGIVRAPISTTAMQVASRLLLVWGVVNNFPFLAKSPAYSSMLVAWSVTEVIRYSYFTFTLSGFQPGFISWLRYNTFFILYPLGISSECWLIFKAIKPARAVRQEYAWILQLILFIYIPGSYILFTHMMAQRRKVMRGKAVQKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8T8</accession>
    <name>A0A3D8T8T8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_00736</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8T8"/>
    <dbReference type="OrthoDB" id="4156714at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="219"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW94973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="553" mass="63607" checksum="C4E7424A1A7A5CA7" modified="2019-01-16" version="1">MPNLHLYLKLAREANMQTPNEPNTIDDNIPFSTNSVINFDTENYERSTMSQQQFSDIATTTSAGADSISMIHSPLHQHHIDMDDSKPRIPGKYLEDSEAERKEHLEKVQEDLTPASTAKQQEMQQYPTDHHSVLGYQMHDAEADQGVSGQRQDPRSIKLQEYNPRLPTEASRSNDSDFKLGLGVSEALRYWRMWKTRFQTERVNLIDAQSIIRQKDQDIKDLAQLLHKKNCQLRQADQDCRQLVWELQSQNNNYDAEIVGLRQALQARDAVISEKDNYNRHLDSQLTRVRTAYRRNLEKEQERLSKQIQSGGWLPEDETKVVTQLQALNSLMKSWAKSFSIQIKLSPDRFRDPDGAGLLEELGKVITMEDSQFPATLCLQTLRVPGLLLNALLAHSIYVDILGDPFFIFTTDGDTRDTKGGASLREVYDDMAKPGSTNCAVNSREAQLWRANTLRSLFPSKLSQEADEKELREKTNQRISGAAERYAKRFSTSYATLLLKEEVHNEDNTCFKKLRGIFQQAAELSYSLWTRKKQDIHLHRTREQLVFCQRAMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8U9</accession>
    <name>A0A3D8T8U9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Choline-sulfatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_00718</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sulfatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8U9"/>
    <dbReference type="OrthoDB" id="96314at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008484">
        <property type="term" value="F:sulfuric ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16032">
        <property type="entry name" value="choline-sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.720.10:FF:000032">
        <property type="entry name" value="Choline sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017785">
        <property type="entry name" value="Choline-sulfatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025863">
        <property type="entry name" value="Choline_sulf_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024607">
        <property type="entry name" value="Sulfatase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000917">
        <property type="entry name" value="Sulfatase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03417">
        <property type="entry name" value="chol_sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45953">
        <property type="entry name" value="IDURONATE 2-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45953:SF1">
        <property type="entry name" value="IDURONATE 2-SULFATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12411">
        <property type="entry name" value="Choline_sulf_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00884">
        <property type="entry name" value="Sulfatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00523">
        <property type="entry name" value="SULFATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00149">
        <property type="entry name" value="SULFATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sulfatase N-terminal" evidence="5">
        <location>
            <begin position="36"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="domain" description="Choline sulfatase enzyme C-terminal" evidence="6">
        <location>
            <begin position="489"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW94955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="565" mass="63649" checksum="3632FCDEF22BD731" modified="2019-01-16" version="1">MAPDLNSVHFAPKETRPAATTTPAPPTQYEAPAAKPNILYIMADQLAAPLLKMHNPSSQIKTPNLDALAAEAVVFDSAYCPSPLCAPSRMSMITGQLPTKIASYDNASSIDPSIPTYAHYLRAAGYETTLAGKMHFIGEQLHGYESRLTSDIYPGDYGWAVNWEEPDTRLEWYHNASSIEQAGPCVRSNQLDYDEEVMYKSTQFLYDHVRKGPSARPFCMTVSLTHPHDPYTIEKKYWDLYEDVDIELPSVTIPFEEQDAHSKRLLKVCDLWDKDFTPEQIKRARRAYYGAVSYVDDCIGRILRVLKECGLDDNTIIVFSGDHGDMLGERGLWYKMSYFESSVRVPLLIHHPKTFAAHRVTSNVSTLDILPTLVDLAHTSLWAGLPMDGSSLLPHLEDREGGSDTVFAEYCGEGTIAPLMMIRRGDWKYITCPADPPQLFNLRDDPKELRNLAGLPAKHPLMSLETSNTLRAFHEEAQAKWDFDGITAKVLTSQRMRRLVWSALKMGHFTSWDYNPTDDGRQKYIRSHMHLDDLELRARFPPVDAQGRAMAKGYICVDQAGSHGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T966</accession>
    <name>A0A3D8T966_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein HRI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_00866</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HRI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T966"/>
    <dbReference type="OrthoDB" id="4045395at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd11692">
        <property type="entry name" value="HRI1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.320">
        <property type="entry name" value="Protein HRI1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031818">
        <property type="entry name" value="Hri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038744">
        <property type="entry name" value="Hri1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043047">
        <property type="entry name" value="Hri1_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16815">
        <property type="entry name" value="HRI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW95103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="211" mass="23415" checksum="3BDD26261BAD9630" modified="2019-01-16" version="1">MAGLISTRLSLRWVPDEATEPTDTLVFNVGSYFMDLRILKADQSIDWGMAGTRDILDQAPLKCRWNKVIDSLGEAGSSDEGTFTKLPNGDDLETGSMPCPHKNDAVTEFEEVWKTLEPSKEFRKAWIVQSLDGMTFLGRIGDAFLGMRQSEDGFGARREALENGAWKDIYVVGKVPSVKEFPDSVDASKWTIGQEFELGGVAFVVRAVEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T983</accession>
    <name>A0A3D8T983_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase-6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_00331</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M20A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T983"/>
    <dbReference type="OrthoDB" id="4676at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016813">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03884">
        <property type="entry name" value="M20_bAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010158">
        <property type="entry name" value="Amidase_Cbmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036264">
        <property type="entry name" value="Bact_exopeptidase_dim_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002933">
        <property type="entry name" value="Peptidase_M20"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01879">
        <property type="entry name" value="hydantase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494">
        <property type="entry name" value="ALLANTOATE DEIMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32494:SF20">
        <property type="entry name" value="PEPTIDASE M20 DIMERISATION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01546">
        <property type="entry name" value="Peptidase_M20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001235">
        <property type="entry name" value="Amidase_carbamoylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55031">
        <property type="entry name" value="Bacterial exopeptidase dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW94568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="444" mass="48793" checksum="32F68208F969D929" modified="2019-01-16" version="1">MALWCPKTGSVEWLNLEEALAGHDLTFFSNLIFSRDTLQTTCAMAGAKDGGLSRLSCDDNDKIARDHFATEVKALGADYVVDAMGCQWATIEGENNSIPPIGIGSHLDSVQTGGKFDGPLGVYTALEVLKVLRASGKKTYAPISAINWTNEEGARFPPGCMSSAVWSHELDIDYAHKCTDTMDRSISIKDELSRIGYLGTKEVSHKTNPLSAHFEIHIEQGNRLEKSGKDVGVVDTIQGMRWFDVSVRGTTRHTDTTYMNNRQDALVGAAKMVLEVERIGRDSKTGMATVSLFKSSPQNFCNIPSIVDFSFSMQHTDLATLKGMEAQIEEFVHKTAQESGLQITNYQNIWSFDPGVFDAEAVSCVEEAAKDMGYSYDKLCSHTGHDSIYTRLVCPTAMVFTPCRDGISHSPLEYASPENCSIGAQTILGAVLRYDEKLRKKYSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9K5</accession>
    <name>A0A3D8T9K5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cdc23 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_00960</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9K5"/>
    <dbReference type="OrthoDB" id="10262026at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007192">
        <property type="entry name" value="APC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF10">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04049">
        <property type="entry name" value="ANAPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cdc23" evidence="9">
        <location>
            <begin position="10"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="382"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="416"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="450"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="581"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="138"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="600"/>
            <end position="611"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW95197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="674" mass="75818" checksum="86151F8000616000" modified="2019-01-16" version="1">MALNERETQQLRETLQEAVVKCSERCLYQSAKWAAELLTSIPTKDDSSEPEDSQMTEAPLEGLPPIVVTGNLDPEEAQLEAKEINNYLLAKSFFDCREYDRCAAVFLPDTILSTFLATNPKATVETSTPKGKGKMGSRPSTASSSELPRLSQKSLFLALYAKFMSGEKKKDEDSEMVMGPHDGGHVVNKQLVTISRFLEAWFNERTNEQGGEIVGSQGWLEYLYGMILAKDKNEEEAMRWLVRSVHLYPMNWGCWLEMTSLINRVEDLNRISQHLPQNICSFIFHLHTSLELYQSAPNLTNSLHQLLSIFPTSPFLLTCQGLLAYHTKDFVSAESHFSQLLALHPHRLDSLDHYSNILYVMNLRPKLSFLAHLCSSIDKFRPESCVVVGNYYSLLSAHEKAVQYFRRALTLDRSCLSAWTLMGHEYVELKNTHAAIESYRRAVDVNRRDYRAWYGLGQTYEVLEMHAYALWYYKRAAGLRPWDGKMWMAVGSCLQKMKRDHEGIKALKRALLADSYYDAGVGSSFGSVGRERGGAMDPEILLQIAGMYERLKDEEEARSYMELCVAQEEGTSADNLDASVINIHNDSPSDDDDRRVSSVSGGGGGGTGEQGTGVTAATSKARMWLAKHAMKTQNYERAMQLATELCQDGVEVEEAKALIREVRVRLENPGISSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q422</accession>
    <name>A0A3D8Q422_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BP5796_13066</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="4">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cyclophilin-type PPIase family. CWC27 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="PDLN01000025">
        <property type="protein sequence ID" value="RDW56601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q422"/>
    <dbReference type="OrthoDB" id="442970at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01925">
        <property type="entry name" value="cyclophilin_CeCYP16-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000034">
        <property type="entry name" value="Peptidyl-prolyl isomerase CWC27 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF6">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0697">Rotamase</keyword>
    <keyword evidence="8" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="16">
        <location>
            <begin position="18"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="213"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="259"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="493"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="259"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="493"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00055615"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDW56601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="538" mass="58840" checksum="12D5F8C4BD584774" modified="2019-01-16" version="1">MSSLYNLEPQPTASCILHTTSGDVSLELWAQQLPLTCCNFLQHCLDGYYDGTIFHRLIPGFILQGGDPTGTGNGGESIYDGGAFGKPKEEGGIWPLEDRKGKNAGPYGVGFKDEFHSRIKYNRRGLLGMANEGPDSNGSQFFLTLGDTPELQGKNTLFGRVEGDTIYNVAKMGEAEVEGDRPTYPTKITGVEVLVNPFKDMVARVRTAAPAIKEKPAEKKKKRKAGKQLLSFGDDGDDEPAPVLKKTKFDSRIVMDVEEDAASKLRSKDDVAPKSKPTSKEIRKTTKTVSIESSPEPAPMPVTAIPNRAAKIEREISSSPEPQVQKVSSLLDRTNAQIAELKASMKRSVQIAPVEEKKKSALEEMIPATSVRGRKRRAGAANDDQRSLDILKAFQSKLEKAPAEKVIAKTTMAAEPTEDTEADDEEAVLCDLHFIANCQSCKSWDTQDDAAAEEDDNDVGWMSHALSFKEDKLGKDLSYRKKAEDELVVIDPREKARTLKEEKRAQREAKAGGSGRAWDQAANERLARASALAGRGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q527</accession>
    <name>A0A3D8Q527_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12993</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000024">
        <property type="protein sequence ID" value="RDW56926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q527"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="59"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW56926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="135" mass="15147" checksum="BB5E55A062E409F5" modified="2019-01-16" version="1">MSSLDYKMFHHEMIFRSINVNVRQVLQRNCVNHIADQGLALFLLESSLSGAKRETYSELFQSGGEQMESQERQELRRSASRSTDSAIKRNKPHSLEARGHERGSRTDCGTTARGGNPFEPGTRAGSHVSARKDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q6D2</accession>
    <name>A0A3D8Q6D2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Formate/nitrite transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_12680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the FNT transporter (TC 1.A.16) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q6D2"/>
    <dbReference type="OrthoDB" id="3459831at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015513">
        <property type="term" value="F:high-affinity secondary active nitrite transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015707">
        <property type="term" value="P:nitrite transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000011">
        <property type="entry name" value="Formate family transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000292">
        <property type="entry name" value="For/NO2_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520">
        <property type="entry name" value="FORMATE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30520:SF6">
        <property type="entry name" value="FORMATE_NITRATE FAMILY TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01226">
        <property type="entry name" value="Form_Nir_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="185"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW57230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="327" mass="35196" checksum="54F6EAA5F47B560E" modified="2019-01-16" version="1">MDAFTPAQTIELISRIGTKKATMRLDKLIINSIMGGLLLGFGCALNVSTASSPWFQTNAPGLIRTIAACFFPVGLIMVFLTGADLFTSYCMYSIVALLHRRITVLHLLKTWVISFLCNLAGILFFGIVLVGYGGVFQSGAFKTEAIAFAVGKAVTPSWHQIFLRGILANWLVTMAVFLSISSREVASKIISIWFPTMCFTALGVDHVIANMFYIPVGIFSGAPISVGFYIWKSMIPAGLGNIVGGGLFVGVVYWYLYLAGSEVSVPFDTTPAQNAVLVPSGPIPQGRTPASTLHDGDSISHIGGIEQELHGSLFKKGHSFKNSEETV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q7A0</accession>
    <name>A0A3D8Q7A0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">D-aminoacid aminotransferase-like PLP-dependent enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12744</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q7A0"/>
    <dbReference type="OrthoDB" id="25921at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046394">
        <property type="term" value="P:carboxylic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.10.10">
        <property type="entry name" value="D-amino Acid Aminotransferase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001544">
        <property type="entry name" value="Aminotrans_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036038">
        <property type="entry name" value="Aminotransferase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043132">
        <property type="entry name" value="BCAT-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043131">
        <property type="entry name" value="BCAT-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050571">
        <property type="entry name" value="Class-IV_PLP-Dep_Aminotrnsfr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42743">
        <property type="entry name" value="AMINO-ACID AMINOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42743:SF11">
        <property type="entry name" value="AMINODEOXYCHORISMATE LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01063">
        <property type="entry name" value="Aminotran_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56752">
        <property type="entry name" value="D-aminoacid aminotransferase-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW57294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="329" mass="36021" checksum="910196DA645A85F5" modified="2019-01-16" version="1">MSTMEKIFSGYHARTALLSHSTHPFAPGVAWISGELVPLSTAQIPLRDQGFLHSDLTYDVPAVWDGRFFRLDEHLTRLTLSCSKLRLKLPLPAEQIKKILTTMVAQSGIRDAFVELIVTRGLQGVRGAKAADLTNRLYMFVEPYIWVMPPAQQLAGSGRAIIARTVRRCPPGAMDPTVKNLQWGDLTRGMMEAEDRGAGYPFLTDGDGNLTEGAGFNIVVVKGGVLFTPDRGVLHGVTRKSVLDVARGEGIEVRMEVVPVEAAYGADELFMCTTAGGIMPITSLDGVAVNGGRIGPVTRRIWDGYWAMHYDPAFTLEIDYEDGKMKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QB92</accession>
    <name>A0A3D8QB92_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_12039</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QB92"/>
    <dbReference type="OrthoDB" id="435881at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050613">
        <property type="entry name" value="Sec_Metabolite_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001">
        <property type="entry name" value="UNCHARACTERIZED TRANSCRIPTIONAL REGULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31001:SF50">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="238"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW59115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="624" mass="69649" checksum="09CAA0EBDB7ED8A7" modified="2019-01-16" version="1">MVESNNPTEGESIVFAGHDQHKDAQVDVDALSGGSRVDDQLLDFVRQQEAGAHDLGHTFWTSLSQEIGGIRQLLEDTAEVETPPELSPDPSDLHHQSSFLFHGNDFDLEHPSDLHCSHLIRFYFSNVHPLCMILHKPTARLYLESSRSSPSQATTESARRGLDALRHAVYFAAVTSMSRAGCMQYLGAAKDSLVMRYMRSCEAALSRADFLNSVEIATLQALVIYVTAIRSHRSNRSGWSLIGLVVRLAHSLNLHRDGDGRAFSPFDAEMRRRLWWHIIVLDIRAAEDRATEPMIYDGSFNTSMPHNLNDSDFDPSSGSLPKAKIGTTDMTFSLICMDVSNTFLVVNYVPPRKQRILSIPQQEDIIKGCTGRIDSIYLAGSVASDPKTWVVSTIGQLLILRLWLVVQYPLQSVRLNKQYFPSGLGLRTATLYLALRESLETSEYSTGHRWFFQTYVPWHALAVALVALCKQTKGPLVEQAWSVIDQGFEKWGGRMADSQGGMLWRPIKSLMRKARAARETHLESLNRPPQLSVSPAPLTDGVDIGLPRLSLEPHGSNTLDPFLIGNFESIHPTIFPCAEVDALNTPGNDPLFTEFADNSTNWDENWNEFLLDAGTFSVDPPFEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QBC8</accession>
    <name>A0A3D8QBC8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fatty acid hydroxylase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12079</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QBC8"/>
    <dbReference type="OrthoDB" id="4350666at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW59155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="419" mass="48235" checksum="F46FF9C37653F0A5" modified="2019-01-16" version="1">MSFCTSTVSTSAMFNTALQGTFEVFHSIQPLRHIYTIFTKSSPQVTVLYCFWLYFAGSFTFDIVHYLLHQCSKSSFKILRSLGYLHQVHHFYFNSRLKFNEKYHWQNTCLELPLELACQICGAWLGWLIAHTVGFTEEEYPIWDLFVFLVVVQSVRVLVVIVENGHDSHHISYEPMVPKDNRWFLVGPQYHALHHVDPNAYIGSTIRLFDWILGTGSSLRSRRITMTGSSGAFGQAMRNQLIAEGAKSIQELKFRTDWTYDDYQSVVPILINTDILILAHGSNSDDSLKANCESMIELIEIFKQNRKAKSANDMLLPEVWYVGSEAELHPLWGSPTMQSYSRSKRAFVPYARHLYSDPSLLYRHIVPSSFNSSMGSAIVSAEWAARVAMWWIKRGARYVPVTYTGLAYINYFKFRFGKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QBZ3</accession>
    <name>A0A3D8QBZ3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_12151</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QBZ3"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF164">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="127"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="214"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="306"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="385"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="6">
        <location>
            <begin position="61"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW59227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="525" mass="58167" checksum="F01B2DCADC2B21A9" modified="2019-01-16" version="1">MADSQSFQSNMEQEDGKDLQELSTHIAEIEEHHNGEIHVHPRPTTDPTDPLNWSLGRKYMVLFVVTLYCTVGISSQSYISNFLPSVQQTFPNASASQINLLLTIITPVVAPTDIFVYLFATTTGRKPVFIVCLITFVIANILGATSPTYTGFLISRILTAIATSPTDALQFTIVEDFTFQHQRGFFLGTLNSMGGLLQAVLTIVTGYMGVSLGYQWACVLYTCLGFVCLVCTWLWMPESSFHRHESELLPQMTPKEYEEWRKSLGPNTELSVWRQLNPLSRISRVEKQTFSQVTQQLLKVATHPTVWWLGCMQVVFLGGYSAMTVYFAQILTTAPWSWPAANVVLINLVYFPQAVIMTLMGWLSDRTLLGLARRRGGAMKTEDRLLTFPIPTISAFTGLLGFGALAQHYLNSPAGTSQPHWFSMVFIYLLINLSFGSGLEVTSIYLAGALDPQYDLAAMTISFAIRDLGSFGLSYGITPFASNVGFFASFGTYAALCVVFGSLAIPFYYYAGAIRKSFGASRSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QE76</accession>
    <name>A0A3D8QE76_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_11731</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Allantoate permease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QE76"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000064">
        <property type="entry name" value="MFS allantoate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF70">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="142"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="170"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="203"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="337"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="394"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="426"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="454"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="74"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW60125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="525" mass="57179" checksum="A1344D3500016ADA" modified="2019-01-16" version="1">MASPIEKNVAEPVSDLSPADEKITAVGTSDADDLGKSDLRIDDEAGAIAVQALASGAVDPVLSKKVLRKIDLYILPFLCVTYGLQFLDKTSLGYSSVFGIIPDNHLVGQDYSWASSIFYFGYLIMEYPGVALLQRFPIAKFLGFNIVAWASILMITAACSSFAGLATVRFLLGMFEATISPGFVAITGIWWTRQEQASRSAIWVSFLGFFGTIGGLITYGIGHIEGSLATWKLIYLILGAFTVIWGILFILVVPDNPATTRWLTEEERIVAVQRVLENKTGTKTRTFVKAQVIEALTDPKIILLALISLVNAIASGGLSFGSIIIKGFGFTSLQTSLMNMPLSFLQAIFTLLGGWAQTKLPNARLIVASVAMIPPIIGTVLINQLDLSNKWGRLVGLWLLAGYPTGFMVLLSLLATNVAGTTKKSVASGMVFVMYCVGQIVGPQCFKTAEAPTYHSGIVAMLVGFILNLVFNLVLRFLYARENSRRDRALEGKSEVELEALREQSRAQGFENVTDVENVFFRYVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QEE3</accession>
    <name>A0A3D8QEE3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_11614</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Cytoplasmic vesicle</location>
            <location evidence="10 11">COPI-coated vesicle membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Golgi apparatus membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QEE3"/>
    <dbReference type="OrthoDB" id="10266042at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051645">
        <property type="term" value="P:Golgi localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09254">
        <property type="entry name" value="AP_delta-COPI_MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14830">
        <property type="entry name" value="Delta_COP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000003">
        <property type="entry name" value="Coatomer subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027059">
        <property type="entry name" value="Coatomer_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121:SF0">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="13">
        <location>
            <begin position="277"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="154"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW60008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="516" mass="57324" checksum="95B03E12C172F5BD" modified="2019-01-16" version="1">MVVLAASICTRGGKAVLSRQFREMQRSRIEALLASFPKLADSGTQHTTVEQDNVRFVYQPLDELYMVLITNRQSNILQDIDSLHLFAQVVTSTCKSLDEREILKNAYELLSAFDELVTLGYRENLTISQIKTFLEMESHEERIQEIISRNKELEATEERKRKAKQLEMQRKDVSRSGRNAPRTPVYPTYTPPSRPAVTDTYDSYEAEKNKSFKASAPKGKGMQLGKKSKTTDMFERVRGDMGAEVEESASSPLVPNHPPSVAEHTHASARVSSSLDRDAIHVTIAETIGAKLSREGTLNSLEVKGDLQLKISDPTLTKVKLDLVANASHGVQFRTHPNVDKGIFNSTKGIQMSNVTKGFPVNNSVGVLRWRATPKADDSSAVPITFTVWVNKGSDDTYTITVEYELTGGDSLNDVTVTIPYATSEPAVSSFDATYEVSGDSLEWVIGAVDDENASGSFEFEAQAEDENEFFPMQVKFSKTRPFIDVDVNSVTLVEMNEEVTFSKDIKSVADSYVIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QEF3</accession>
    <name>A0A3D8QEF3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_11811</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Preautophagosomal structure membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QEF3"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034045">
        <property type="term" value="C:phagophore assembly site membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000470">
        <property type="entry name" value="Serine/threonine-protein kinase RAD53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045269">
        <property type="entry name" value="Atg1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24348">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE UNC-51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0072">Autophagy</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="9">
        <location>
            <begin position="126"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="283"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="678"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="779"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="894"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1179"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="907"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1179"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1208"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="312"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW60205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1264" mass="142163" checksum="0522CE34DA404659" modified="2019-01-16" version="1">MEEEATQPAAPLVQFDEQQNVNEDKLLATQIVIDPRRLGQHNSGLTDEDLTDVFCILHPASLPACRATAMIAEASPEHTLVPNSAAVKFKDNKHRVDSFDLASNGIVSHDIALRLSAKLKDPRAGHCFGRNPARCDFVMGHADEVKRISNVHFRIFINEYGIIMLEDQSTNGTVVDKVILRGKDKENGGGYRHTLENGAIITLAMTPPQEDFRFIVRIPQRDETDAEAFRGRLTDYFMNMKLEHEKGKVQTPGEKKEPLNLFATQNMVSSLSRPKEWRGGSKYNKVCMIGRGAFAVVHKMTRKFDGVPFAAKELEKRRFMKNGILDQKVESEMKIMRKITHENIVQYIEHIDWEDYLFIIMEFVPGGDLGSLVEANGPLSELTVKSMSIQLLSALKYLHNMGITHRDVKPDNILIQREVPFHVKLTDFGLSKMVDSEETFLRTFCGTLLYCAPEVYTEYREFDATGKRNMRGRDKRALPPQRYGHAVDIWSLAGVLFYAFCGRPPFPVKTGTTYQELLSRIMAEPLDIRPLQHAQVSDNGIRFVRNMLHTRPEHRATIADLEASPWLNSTNTEMAEDDEEYSQNFDEFDEKENLERGTSQLSIHEEYRQVDHSGEFGSSDVTEIQQPEIPSSFNTSDGNYSENYSFVQNARGGYGGRLFGEVDVSALGSSGAIPSLSDINLPLPSQHDPQLDESLGSRGNQVSQSDQDENTHAVARPSIEVSHPDSDTRHMEHVNVAKNPMPPPPVPNFQHAVRDYDLDKRAERSSSLMGAESMVGHLNMGSPSDTPSPAAERLASPSLDPNYNIGASLRRRREDEDGEGWWPEEVKASKRRKSNREVVLPMPTSIFWDPKDKSTHHENYPRMTSSEFEAFERVAKENGEEFRNGGRFFNKTMQSFRSSRSPSIEPDATHRATSEPTKEEGRRMLMKRDDRKLGVDSAEASKDSSKDVLDSAMPSTARGSNTTMGLAIQVNAGSFDNTGLQAVHANTFLPPKRLLAKMIATHDCIIPSLSLNVVDPLTTWGRGFTNTLRYADSYQVKVPKYAFKLLLYKPGFYNDGALLDHAGSGTPWNSHDGPDQDLTFYISSKATAGIIVNGVKLPSHDRQKPLTESVYWGELHHGDEITLWQHDVNPDEHTKVRFECYWGKSKEPRTEPFQALPAGDLLSGIERVCLAKERFLESEKKRGAEEKQRKETEAKEAEEARKQKNLHAESSQRTTSDSHSARQIPRTTSAPAVPTSHRQDFSQSFRTAPSFIDEAPQIGFKKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QEM4</accession>
    <name>A0A3D8QEM4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CRIB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_11716</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QEM4"/>
    <dbReference type="OrthoDB" id="5237293at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000095">
        <property type="entry name" value="CRIB_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50108">
        <property type="entry name" value="CRIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRIB" evidence="2">
        <location>
            <begin position="183"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="763"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="806"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="71"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="564"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="813"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW60110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="838" mass="91478" checksum="EF5D60186D55396D" modified="2019-01-16" version="1">MFSFNKSPGIQTSHFQNSKLTRDSVPVSQLSETYITSTESFEAAIDGPPSPERIRAYTEQMRRSSIFGNNSRTHTLSSGSSSYRSGESTGNSTDNLSSLSRKSSVRSNASSMYSAEKPEGGQSLGKAIFSRTARKLRRESAGTNEIGKMKEEEVSAREKYYGKASTSRPGTAGSAYTKGRPRISSPTNFQHVTHTRQEHLPNLARSSRTELASEFTAIRASQLPTRGELKGILAEDLHFQNFSSEMVNDDSSRAHRSSPDKPYNTYRESAILPPQPFRTKSHDMLRQAPHRPPRSPLYPQDLPTRTSSRIASTVIDEFNLFPPPSAERPQTSGGYPRLDNMVSETPQSPIWSEQDSYFDRPISHAVTTPGDEAWPLKATSLESPVQILENVPEEDESVAAKRRSGHNGELRFSQSVPALRVLNREVVEERPETGMSTISGKAFGRVIPDADPSPKSATFRMNHASWEDDIDYCYEHEAEADCDYQWDRHSLEATRPSQVASPEVSPKSAIQIQDSERAYHGRFRPSLLVPSKYEVPELSPLSQISLSESDPRTPSGLRPAHLRSPSQASSFKESHGFSLSPSLLIPADFGAAMDQDHLYDELDRAHAQDYSSSATIFPRDSYGNNPASPIDESISSTASYRSSAFSRESARSSSCTRISARSHTSQESLLLLNAGTVSQAHRSIGSASSIPDLIPSGPRNRASNISLTMGGMPSTANLAGGEETAQAAVVLGTPIATAQPRRKNSLLAEQVLRKAALDTLLSPTNEGESLSPVAESFPSLPRASGATDKLHGRKVSAPIMSPTVKEFKGRARASSTTMSVTGKTKTRGSNYMLFPPTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QHN6</accession>
    <name>A0A3D8QHN6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative NADP-dependent mannitol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_11207</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QHN6"/>
    <dbReference type="OrthoDB" id="417891at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009688">
        <property type="term" value="P:abscisic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF4">
        <property type="entry name" value="CHAIN DEHYDROGENASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08710)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW61315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="276" mass="29765" checksum="8D089E0C300F638D" modified="2019-01-16" version="1">MGSVEGAAATASMSTLPQEGHNWQITLSDKVIAITGANQGIGLGLAEVCLANNAAQVFSLDISSPGEDFTTMQKKYPNKIQYIHADVTSEESVAKALEEIVEKTGRFDGMIANAGMTRHQPALDFTMAQVEQLFKLNVYGAWNCATAAARMFIKLKTKGSIVFTASMTSYRPNRAAPSAPYGATKGAVRNMTHTLAMEWAEHGIRVNSISPGFVKTALTYYVEQSPDWDTKMKYYGGMPRLALPQELGGAYVYLLSDTATYTTGIDIPIAGIVGAW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QHN7</accession>
    <name>A0A3D8QHN7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_11255</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QHN7"/>
    <dbReference type="OrthoDB" id="4314040at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="20"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="197"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="110"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="202"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW61363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="746" mass="83532" checksum="D7A179D23DB03B3E" modified="2019-01-16" version="1">MYQPLRPRFKKTNIVRARTGCQTCKRRKLKCDEGKPECKACIHRGIECEGYAQRIAFRNDTSSTVQRVTNLEKQKWKVIRAEQEQESTSKKSARKRKRSRDSSENDDKQNSNLTESSTRSTATKHLMVDGSKSPTTSRPYGHENNISDSSAGSLKETSNAATQLLALSGSLKRRCLSYENIDLASLDGGVSSHKYEASEYQTSDTTNTPSTTVTRRDSYMDSGSSCGPSRTELTLDYGSLCDEMSTPSTSTNSTERERWSYFPATITNLELTHTEDSYILYWCTTLLPQLPPVFRRCQSTWSQFKYFRNATLSLASADIAHANIGRRGSSKKQASSMSQHRLNSLDYYSEALENLSVASSTTNDLVEECAKLAVLLVFAFFEMESGTFAGSVVHVRQMDKLISENIHLYSTSADGKDLICACTALRAQLSCDCIPWRSNGFPHCTASNAINLCIQEAMQHSATPYEHLIPLLAEICHLNELVSMGQTFGFDSSISTYRAWVKSLDDFGYCSPGLQLSEEHSPSELLGRLKAATLMLDTWHNSLEVLELPFEGHTSLDTEKCDNVPGIRVKPLRFHNHESAMNYARYACAQLFCSKSNLDRCTSLSAPDPNEVSAWALLILRIVAGLDPLACVEQNTFKIGILWILSRIALLCASNEVVAWIEFWLQKAWQSGVSKEASIPLSIILKYVRKIRVLQDDGYRVLFMFCSITGKCERFSLYSEESSFRALIYGIDTKRDSILSSSVIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QI87</accession>
    <name>A0A3D8QI87_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_11444</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QI87"/>
    <dbReference type="OrthoDB" id="47494at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178:SF1">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47178">
        <property type="entry name" value="MONOOXYGENASE, FAD-BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="316"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW61552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="435" mass="48451" checksum="AD05538574419C81" modified="2019-01-16" version="1">MAATKLSGSDPSPQPGDHILIIGAGITGLTLAQALRKRNSENPSAAPINFSIYERDEHALARGAGWALSLHWALGQFTALLPQDLVQRLPEALVDPDSAARGELGNFRLFNLQTGKDDFMTPPSDSPRNRFSREKLRRLLMKGLDIHWSKNLETIDYPKQGEVVAQFSDGTSATGTILVGCDGSRSQVRRVLCPANYKNNVVPIRLLGVTAPYSPERCKPIQALDRYFFQCCDPATDTFMFYGFLNVPTLKEQNATTETLPITCQVLTSWPYRPGFMGKDEVTEVPVENNERLMLMKNFSSGWAEPFKQLVHDIPDTAEVKVINLEDWPPQKSAWNNREGRVTLIGDAAHAMTMYRGEAANHGIADVRVFLEQFLPGEGEALQSKIDAYEIEMIERTRPAVLRSRKACIHAHDYASLTDQSPLIARRAIVVDDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QJL1</accession>
    <name>A0A3D8QJL1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative transmembrane protein 34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_11516</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QJL1"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="257"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="553"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW61624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="607" mass="67955" checksum="E44475FEADA7BF17" modified="2019-01-16" version="1">MGFNTTCNATLDNMLIGASEEIIVGNLTFHNLAILIAAACSFIAVLVSFYLIWMHALHYTKPYEQRQQVAPAFPPCLALMVLSIIRILLMIPVYAVASFLELYFYTNEIYFAVISDCYEAFAIASFFALLCHYVAPNLHDQKEYFRSITAKPWVLPVNWLAKCCGGERGIFRTPRSGLTWFNIIWTGIYQYCFIRVAMTITAVVTQYFGRYCESSDSPVFAHVWILVIESIAVSFAMYFIIQFYIQLRKDLAPHSPFLKVAAIKLIIFLSFWQSFMISFLTSSSLNIITPSSLIAYPDIQIGIPALLQCVEMALFSFLHIFAFPWAPYANNAAPTKYPMSPTSGSPSGNMIGPKQGGFLGLKAFVDALNPWDMVKAFARGMRWLFIGVKHREQDPSYQNATFNLNTDNENDMTLQPTGGKEGKFIAGELPIANEFRRSKFGMPMSTPARGRSDEAAGLITNAQPNPLNSASSGYVPARQRYDADGQDISDGMYHVRPAQDNPHKFMSMNPEPNQQIGMALSGEPGPYQAYVSPNAYEQPPSQVYLEQLRQERRLQQEAASRQWPQAPKPITPITEDDEYSQSSGNPHVHNALWGNGPQPGNLNHGAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QL06</accession>
    <name>A0A3D8QL06_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_10797</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QL06"/>
    <dbReference type="OrthoDB" id="3253298at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13637">
        <property type="entry name" value="Ank_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="76"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="637"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="872"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="948"/>
            <end position="980"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1119"/>
            <end position="1151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW62495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1240" mass="138299" checksum="7BF7A25308D0AA7D" modified="2019-01-16" version="1">MGDSIFDESSEPSAGAIDISQSVVWTHARSISLRGTGQPEVEPDAESAANVAQNACLLFAKIASDAMLPCVGITDYDTSDPLGTGLSFDVAGMGLSPQVPWYRASLFQSNPTIAVKRIRAGRIHDEATASQLRPLLQSIILELQILTHPSIRQHENIVSCFAAGYQHFSYDNTYLLPLIVLEYTNWTTLDNHELHLQPFGISRTDQINCLVDVARALNFLHKAAITHGDVKGSNVLVYFLPSEAREIVGRERTFIAKITDFGCAHVNDGRDSRLPGLTPLWAAPEASSVIAADLIHKADIYSYGLLVCYVILDQDFSEMFELEGDRLEQVRSLNVLKRNDSLLEYAERALEKKISPKLNLNNILQVLRCTLQKDPSLRTLETIESFLQPKHGKAPKQRLQYNDTLPSKIQPLEKIDDLSLLLSTREDGILYPSKFFDCDWSTQSYIVRNLICEWESNTNSKPRRGHAALELCICYLNGFGVRSNNSKAAEYLGYAVSSQSKQAQHLFYRLQKYLSANFRPNNQTIEWLIDGMSSPGFTSHIAAQDLAAIDMERYLSTETALVSTYRISSCSVGEVLLDFTNLGSLQQAIRLLPTPHNSILTNNQEPLLHAIVACGQIDAAALILNNLNLDMNICNELGETPLIAACQAGDRRMTELLISRGAKYLSNTKAQISPLHYLVRFREEDVDEVTGLLLKAGYPVNMNIENSRSPLYWASSRRALRHVPTGLARNNLPAIKALLKHGAEIYPNGYSKGRLGGAVQRAAMMHNLEQLKVLLNATAPQDASKVGRLLHWILDNKTVTTFERILFTGPDINTTLQELIQCALRYEKDIDKLNGYGESALFFSVAKGNAQTVQNLLKTKCIAQLNAPSGRHMLQPLMLAVSLGVGDLVDTLLKAGANINSTFGKLEETCFHMCSRKSGSIEIAELLFKYTQGSTVKGDRLLDKPRKDGRSPYHLAVYQGHFKLADWYVARGANVEATLYVITWNFSVSRVLPRRRMLGDYHRCERQAQDFLLQQPLPSSYICQPVTILGSLLPYKTEHTMSRLQALLGSPTREKPAFIVSPKFGLNALHFAVAELYESFTEYRSRMDSVTRSVLADAPLAFMLQNFFSPEQVNHADKAGWTALHIAALNSNVQATALLLEAGGNPNLCTKGQWTVLDCAYVARAKWGESPTGILLKKIMPSTAHVENLAWLTIRTDRIIELLERKEAQRKQKSGFLTKMKLMTYSREWSFYTYLDATKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QL48</accession>
    <name>A0A3D8QL48_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nap family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_10845</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QL48"/>
    <dbReference type="OrthoDB" id="19419at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="296"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW62543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="333" mass="37174" checksum="364E7EE1FD55654E" modified="2019-01-16" version="1">MPQKFAFTTAAMAAALEDTPITYEDLAEIEKDFDDADTEIIKQQVALTAPLYARRAKTVSQIPNFWPLVLEQAPPDIDQFIQPSDSALLLSSLTALNVTHFELAQEPQGDPRSISIQWTFAENEYFEDTRLEKRFWHRRGKDGWSGLVSEPVQIKWKKGKDLTGGLLDLVCQAWEAETRAETSTSMSPEQRALRKKIENTGMGGLSFFAWFGYIGRKISKAESDLAKSREAERRTLMKSGLEVQESIVEEEDAGDDDEDVGMSLEIFPDGDDLAVAITEDLWPGAIRYFTQAQEQDALSDADFESDDEGMDDGSEPGDSADEAERPAKKPKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLC0</accession>
    <name>A0A3D8QLC0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein BZZ1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_10897</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Plays a role in endocytosis and trafficking to the vacuole. Functions with type I myosins to restore polarity of the actin cytoskeleton after NaCl stress.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the BZZ1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLC0"/>
    <dbReference type="OrthoDB" id="8783038at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030864">
        <property type="term" value="C:cortical actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045010">
        <property type="term" value="P:actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030833">
        <property type="term" value="P:regulation of actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20824">
        <property type="entry name" value="C1_SpBZZ1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11912">
        <property type="entry name" value="SH3_Bzz1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1270.60:FF:000060">
        <property type="entry name" value="Actin polymerization protein Bzz1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.40:FF:000161">
        <property type="entry name" value="Actin polymerization protein Bzz1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.20:FF:000040">
        <property type="entry name" value="Actin polymerization protein Bzz1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.40">
        <property type="entry name" value="SH3 Domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035459">
        <property type="entry name" value="Bzz1_SH3_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020454">
        <property type="entry name" value="DAG/PE-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036028">
        <property type="entry name" value="SH3-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001452">
        <property type="entry name" value="SH3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735">
        <property type="entry name" value="FCH AND DOUBLE SH3 DOMAINS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15735:SF21">
        <property type="entry name" value="PROTEIN NERVOUS WRECK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00130">
        <property type="entry name" value="C1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00018">
        <property type="entry name" value="SH3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14604">
        <property type="entry name" value="SH3_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00008">
        <property type="entry name" value="DAGPEDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00055">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00326">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50044">
        <property type="entry name" value="SH3-domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50002">
        <property type="entry name" value="SH3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00479">
        <property type="entry name" value="ZF_DAG_PE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0728">SH3 domain</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="F-BAR" evidence="13">
        <location>
            <begin position="8"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="12">
        <location>
            <begin position="409"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="11">
        <location>
            <begin position="573"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="SH3" evidence="11">
        <location>
            <begin position="668"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="459"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="518"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="463"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00054085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00061387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00074946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW62595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="726" mass="80489" checksum="FF1C0A8CBF973D15" modified="2019-01-16" version="1">MADVDIAPQFGLELKFKDAFKPVNAWVGNGIAWLDDIQQFYRERSTIEKEYSAKLNALAKKYFERKAKKSSSLSVGDTPAMTPGSLESASLTTWTTQLTTLESRAAEHDRFSKELVSQLADPLKVLSGRFEELRKHHTEYADKLEREKEGTYGDLRKMKGKYDASCQELENKRKKAESAFDYSKTKAQNAYNQQTLDMHNVKNSYLISIRVTNKQKEKYYHEYIPDLLDSMQDLSESRTVKLNAIWSLAAQLEIGMLSRSTEFVNYLATEIPRNEPVLDSMMFLRHNVGPWQEPADKVFEPSPVWHDDDAMVTDDTAKVFLRNVLGKSKSQLGDLRRQVDTKRREVEGSKRVKQLIREGKDKRDEVEVVRAIFFLQEQLHQVDHQRLTAEVETTTITEAVGDVTLGAKSHNFKSQTFKIPTNCDLCGERIWGLSAKGFDCRDCGYTCHSKCEMKVPAECPGEQNKEERKKLKAERQEAAGGSTRPVSMAVGSAAELPGISRTNTMTSLSSGYSASAQRSISGIPKTPTDEAAPERSNTLKASSANTLRKHRVVAPPPAAYISELPGSAPNGSSSEKQGKMLYGYDANGDGELTVTEGKDVTILEPDDGGWTKIKSGGQEGLVPTAYIEIIASAPARPASMYSNSGSSMAGSVTTKKQGPAVAPKRGAKKLRYVEALYEYTAQSDAEHSMAEGERFVLIKEDPGDGWAEVEKGGFTKSVPANYVQAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLP0</accession>
    <name>A0A3D8QLP0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_11045</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLP0"/>
    <dbReference type="OrthoDB" id="25503at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd12909">
        <property type="entry name" value="SPRY_RanBP9_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013144">
        <property type="entry name" value="CRA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024964">
        <property type="entry name" value="CTLH/CRA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006595">
        <property type="entry name" value="CTLH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035782">
        <property type="entry name" value="SPRY_RanBP9/10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050618">
        <property type="entry name" value="Ubq-SigPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12864">
        <property type="entry name" value="RAN BINDING PROTEIN 9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10607">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00757">
        <property type="entry name" value="CRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00668">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50897">
        <property type="entry name" value="CTLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="178"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="CTLH" evidence="4">
        <location>
            <begin position="455"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="25"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW62743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="683" mass="74738" checksum="C2948381B27B4468" modified="2019-01-16" version="1">MTNSYPSGSAGMPTGPLGAPGRRSSYASVVSGATSSQNLPRSGAFSHLLNQHPADYSYDPSYQNVGGHSRHDSRGYEVDTNGGRGAAGSWGRSAQLPSFSSAFGALAGGWGTPEDLFVTPSYLKSSKYVQRLRQAHHAKLAAHRDGPSASSSQPGSLSTSASSVNLHAKMTPSHRGMTYDLIEKAPPLEEESLSPLPTKWNPHDKYGGLEVLSDGQEVKFTGPKSTSDRDHEACAIRADYPMPPQCGIFYYEVTIVSRKREESSIGIGFSSKSVPLSRLPGWEPESWAYHGDDGCSFGCQSSGKSYGPPFTAGDVVGCGINFRTGSAFFTKNGDHLGTAFRDIKGKLYPSVGMKKSGEHIRVNFGQSPFVFDIDGMMAHEKSQIQHDISETSTSRLAPPLSETDLIQQLVLQFLQHDGYIETARAFAEEVHAEKQALNLDPNTVVESFNVKEDEDAGHRQRIRTALLDGDVDKALKYTNAYYPHVLKDNDHVYFRLRVRKFVEMIRQGAEIHNATSMNGTKKSNGHADNWYDDNINQEMELDDHTTQNNNWDKMDTGEPSDSLKYLNLMNETIEYGRVLQAEFKDDQRREVSKALEDAFALMAYPDPTNAKEVAHLLDPSGRVAVAEELNSAILLSLGKSSTAALEQLYQQTTVLLEDLAEGGAAGAFVNIDDYTRPASLAQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLT0</accession>
    <name>A0A3D8QLT0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="11">MFS general substrate transporter-13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_11019</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLT0"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000061">
        <property type="entry name" value="MFS sugar transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF68">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="83"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="168"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="387"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="431"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="455"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="22"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="530"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW62717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="562" mass="61779" checksum="E63D5A63FDF36C5B" modified="2019-01-16" version="1">MFGSKTGTRYFGLRGQKLNNAVGIIAGLDFFLFGYDQGVMGGLLTLGSFVDTFPEINTTKYTLSNGYPASVVNHVSTIQGISVASYNVGCFIGAVLTIFIGDILGRRKMIFLGSTIMVIGAALQCSAFSLGHFIAGRVITGFGNGMNTSTVPTWASETSKSHKRGKMVMIEGAMITGGIAFSYWLDFGFSFAEPSSISWRFPIGFQIFFALILVALILELPESPRWLILKGKEDEALSVLSALNDMPPDDHIIQSEFAEIKDTVLEMKAFGYRDLFTMGPDRNFHRVVLAYVNQVFQQISGINLITYYAATIYQTYIGLGPLTSRLLAAANGTEYFLASWIAVYTIEKFGRRSLMLFGAVGMSGSMAILAGTNYASSLNIGGSAPGIVSATFLFVFNTFFAIGWLGMTWLYPAEIVPLRIRAPANGLSTSANWAFNFMVVMITPVSFTSIGYKTYIIFAVINAFIVPVVYFFYPETAYRSLEEVDTIFRKTKGWFNVVSTARNEPNRYGKHGELLIDYVETEEHAFRRQSVASHGVKPTSGNVEHAENGSHEGSTYEPKQEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLV5</accession>
    <name>A0A3D8QLV5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_10932</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLV5"/>
    <dbReference type="OrthoDB" id="4509729at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW62630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="202" mass="22737" checksum="2BD8D76283573C30" modified="2019-01-16" version="1">MAKPHHRPSTAERDFTLQKYLLLYSQHDAVRKNISEILPRHYSTTTRTSPSSPSHSPDRHSSFSSSGSDDGFYLSSSPPRTFRNHIRGGSIAATTSCSRRASLPALAEEQQRTSRALSAAAASSGLGERTLELVWEQEMKLMNVNQQIKSTLTELLNCDAVKADQAYRMWVQSRLMDTEKELKTCKSRNCERRRSDEVSAVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QM20</accession>
    <name>A0A3D8QM20_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP-binding protein EsdC</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_11040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QM20"/>
    <dbReference type="OrthoDB" id="5364946at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40625:SF2">
        <property type="entry name" value="GTP-BINDING PROTEIN ESDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40625">
        <property type="entry name" value="GTP-BINDING PROTEIN ESDC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="203"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="206"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW62738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="32780" checksum="83F2C7D58CB21DEF" modified="2019-01-16" version="1">MAAVQLSFSLRTSSGVKTVHLLGSWDNYSGQLPLSKDKSSSKSGAWKGTFRFQGATLQPGQRYWYYYIIDGYHVSHDPAQDSTTEPTTGRVLNILDVPTEKSHKSSSSSKSSSRHTSSKEKSSSSKHSSSRDSKHHSSSKRSTRRESDLSIDIPKGRPLSTSEIQSPKPVTPHATQYILQSDYSYPTVGDLTSRFSAVTMQEYEYDSTGSPPSSVGSSLSSRSDSSSPSDSASSLSDYSSGSAGSCCTCERYGITRKGDRVKLDCGGSRCNYEEDSSNCSSEDDEYLPRNSRREGIVVRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQ04</accession>
    <name>A0A3D8QQ04_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tetraspanin Tsp3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_10374</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW63872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQ04"/>
    <dbReference type="OrthoDB" id="71600at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018499">
        <property type="entry name" value="Tetraspanin/Peripherin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008952">
        <property type="entry name" value="Tetraspanin_EC2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00335">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48652">
        <property type="entry name" value="Tetraspanin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="76"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="220"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW63872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="280" mass="31431" checksum="F6796533CB20211D" modified="2019-01-16" version="1">MTTLFAKLLVSVGPLLLLTLMAVAGYAYHQILTLNLPIPQALGLLTLVLPLITGISTQGARGLIQRSRHDQYQLTLPLIAVIGFQLIYETIIATLALTYILPPDSLACGLETRWLKLWQTKDARAIRAIQDRFDCCGFNSMKDRAWPFTSAPACTNAYPLRQQSCVANWRQTEQTTAGILLLIALIVFMLKVISLIYLLTSSSWMNGSVTRRFKQLTGMTDEDTEDNRATMRRLIEEGDRSASYRDEEEPEPSDQDQGPRVVPSPLVESNNQWREEDGRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQI5</accession>
    <name>A0A3D8QQI5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_10585</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the krueppel C2H2-type zinc-finger protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQI5"/>
    <dbReference type="OrthoDB" id="654211at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000141">
        <property type="entry name" value="C2H2 zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000464">
        <property type="entry name" value="Zinc finger and SCAN domain containing 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="504"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="12">
        <location>
            <begin position="533"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="385"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="436"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="596"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="402"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="451"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW64083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="623" mass="67956" checksum="614240E28264FC28" modified="2019-01-16" version="1">MDSSYQFAQVMGQPSPFFYYTPDPKPDNRQHGHFSQQPSVPMPMHYQFQQMQAMQPMPSTPIYSRPNSASSQPPMPIYNPAYAMNMTPMASPQPMYQKPTILIQDHSPRVMMEQECNEAEMYYYPATPPLSASGSTISSPSNCEVLPTPMNATFFGLEGFEGVKEGCEGDVQAENLAGNEWARCGSPPMTPVFIHPNSLMSSNASELLSATSCPSLSPSPSPYPHSVTSEPQQQEFDFCDPRNLTVGAVTSAPSASQISNPTLGVEFPPLPTLCSGDDEEHRFMLGGDTFVKSNSHAHSFNFSVASTIDGLPTFDDLSDLDSEEDFVNGLVNLQATEHVQYLGAKRQRTVSDLSASDLLSIHNEEFVSEDDLEDFEESEKFAAVALPSPPASGSDSEIKQDKKPRKKSKKAAKSANCSEDSSAFDNLVRSRKFKAPMNNASGDKAPESAEDQQASTAPSHSGSECTTGNVNAGTESNNGATSQQPTVNRRGRKQSLTEDPSKTFVCTDCNRRFRRQEHLKRHVRSLHTQEKPFECHECGKKFSRSDNLSQHARTHGSGAVVMGVLEEGELADDMDAPDGEHVRTLGNVLFNVAAAASGSDTERSSDGSSGNDSQARKKRKRSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQT7</accession>
    <name>A0A3D8QQT7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Peroxidase</fullName>
            <ecNumber evidence="14">1.11.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BP5796_10671</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 Fe(II)-[cytochrome c] + H2O2 + 2 H(+) = 2 Fe(III)-[cytochrome c] + 2 H2O</text>
            <dbReference type="Rhea" id="RHEA:16581"/>
            <dbReference type="Rhea" id="RHEA-COMP:10350"/>
            <dbReference type="Rhea" id="RHEA-COMP:14399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
            <dbReference type="EC" id="1.11.1.5"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Forms a one-to-one complex with cytochrome c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.-" evidence="14"/>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQT7"/>
    <dbReference type="OrthoDB" id="2859658at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004130">
        <property type="term" value="F:cytochrome-c peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000302">
        <property type="term" value="P:response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00691">
        <property type="entry name" value="ascorbate_peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.420.10:FF:000009">
        <property type="entry name" value="Ascorbate peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.520.10:FF:000005">
        <property type="entry name" value="Cytochrome c peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.520.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.420.10">
        <property type="entry name" value="Peroxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044831">
        <property type="entry name" value="Ccp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002016">
        <property type="entry name" value="Haem_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010255">
        <property type="entry name" value="Haem_peroxidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002207">
        <property type="entry name" value="Peroxidase_I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019794">
        <property type="entry name" value="Peroxidases_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019793">
        <property type="entry name" value="Peroxidases_heam-ligand_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356:SF58">
        <property type="entry name" value="CYTOCHROME C PEROXIDASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31356">
        <property type="entry name" value="THYLAKOID LUMENAL 29 KDA PROTEIN, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00141">
        <property type="entry name" value="peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00459">
        <property type="entry name" value="ASPEROXIDASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00458">
        <property type="entry name" value="PEROXIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48113">
        <property type="entry name" value="Heme-dependent peroxidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00435">
        <property type="entry name" value="PEROXIDASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00436">
        <property type="entry name" value="PEROXIDASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50873">
        <property type="entry name" value="PEROXIDASE_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0349">Heme</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 14 17" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="Plant heme peroxidase family profile" evidence="16">
        <location>
            <begin position="184"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00038574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU363051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDW64169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="374" mass="41488" checksum="C4D01D44AFBADBE6" modified="2019-01-16" version="1">MASASRTFARVALKSTPATSAFKTASRNSAFASARQTFRQQSRRAYSSEPTPTKSSSGLYLGVGAIALAGAGYYFYSAGNGSLLSGSASETKGLFTPKFEDYQKVYNEIAQRLEEKDDYDDGSYGPVLVRLAWHASGTYDKETGTGGSNGATMRFSPEGDHGANAGLKAARDFMEPIKQKFPWITYSDLWILGGVAAIQEMQGPAIPYRPGRQDKDMAACTPDGRLPDATKNQSHLRDIFYRMGFNDQEIVALSGAHALGRCHTDRSGFSGPWTFSPTVVTNEYYKLLLNEKWNWKKWNGPKQLEDKTTKTLMMLPTDMALIQDKAFKQWVDKYAKDESLFFKDFSNVIVKLFELGVPFEETTQQAPMIFKPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QTU1</accession>
    <name>A0A3D8QTU1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_09901</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QTU1"/>
    <dbReference type="OrthoDB" id="8904098at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071916">
        <property type="term" value="F:dipeptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000085">
        <property type="entry name" value="MFS peptide transporter Ptr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000109">
        <property type="entry name" value="POT_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11654">
        <property type="entry name" value="OLIGOPEPTIDE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00854">
        <property type="entry name" value="PTR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="263"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="288"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="387"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="457"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="503"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="539"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="568"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="609"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="618"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW65209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="628" mass="68354" checksum="854491218283781F" modified="2019-01-16" version="1">MSAEHPNPLEPSVFATSVPEAVAEPHGRSSYAAIENIGAPYHSKEAPEDDVEAVTAGDGVDESEYPAPTEEEKTTLRKISDKIPAASFALCAVEFAERASYYGTTTVFTNFMENPLPRGGNGAGAPPRGTEETAGALGKGLQFANAFVLLFTFLAYVIPLLGAWLADTRLGRYKVIALGVALCGVAHVIMIIGAIPKVLQGSAAVAPFMISFFILAIGAGLFKPNIAPTVLDQYQNQRQYTKVLKSGEKVLVDPETTIQRMMLIFYGLINVGAFYAVGTDYAEKYIGYWLAFLLPGIIYFLLPILLLVFYRKTIKVAPSKSAYDNVYKIIWLALSKNAMRIGRKGFWDPARPSVMRGNGITTYKGQPIPWDDALVDDVHRTFSACQIFLYFIVYNLNDGGIGSVLTSQASTMTTAGAPNDLLGNFNPLVIIVAIPILSHVVYPLLHKYKIPFGRVTRITFGFTLAWISGIIGAIVQWRIYKTSPCGYHATGCTVGTGVSPLSLWVQIPTVALGALSECFCNVTAYELAYARAPPGMRSLVMSLFLFTSALSAAVGEAVSPAIADPYLVWVWAGPAIALAVFTVHFYWTYRHMDNDEFMIRHQEGEISNSRLVSEDASEPEKLAEKPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QU03</accession>
    <name>A0A3D8QU03_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_09961</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QU03"/>
    <dbReference type="OrthoDB" id="5280547at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DBAG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW65269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="571" mass="63243" checksum="D617039225ECDC4D" modified="2019-01-16" version="1">MVFCGKPSKGCMSCRKRRIKCDLAAPACSQCVRSEQQCSGYRDLQALMFRNENAKVIRRARVPASRAGSASASGSTPSSPRVKKASLQNGQFLTPETSPDPDPVSFDSDVVEEEAVTTLTDKRLVYVTSTAPDLPFCRLSSSIEDQGISFFFNNYMTFMSSTPSGLTDVFSSPLFQEVSASKKVFDAVSSVGLAGLSNVNKDKKAMVVARRKYSETLVQIRDSLDNPDRAGLDYTLKAVVIMAIFEIVNSTGATHDSWRVHINGAVALMRSGALKKLKIRRSMRMQLQFCFSSLIDHYNRGEVFPPSMIKWSEDCRASQAPSDSPAAVLLDIAVRFVNLNASLITKSIVSPRDIIASALQLERELDAWASTDVPPTLQYEVIEGEDDSPMFFRGRYHIYQDLWSAKTWNHYRWSRILINELLVTNIHALPLPLAASLHSQHEKSLALIRQLANEICSSVSSECCRHTVLHSTYTTVAPQMSGIFLVLFPITVAAGAVGVAEETHRWCLNTLSNIGNRMGILQAHNLVPMAVTARRRWLNLGLHLTPGRYMNVEANGTWRILRAADAELVLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QU30</accession>
    <name>A0A3D8QU30_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Tafazzin family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_09991</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>1'-[1,2-diacyl-sn-glycero-3-phospho],3'-[1-acyl-sn-glycero-3-phospho]-glycerol + a 1,2-diacyl-sn-glycero-3-phosphocholine = a cardiolipin + a 1-acyl-sn-glycero-3-phosphocholine</text>
            <dbReference type="Rhea" id="RHEA:33731"/>
            <dbReference type="ChEBI" id="CHEBI:57643"/>
            <dbReference type="ChEBI" id="CHEBI:58168"/>
            <dbReference type="ChEBI" id="CHEBI:62237"/>
            <dbReference type="ChEBI" id="CHEBI:64743"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:33732"/>
        </physiologicalReaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:33733"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Mitochondrion outer membrane</location>
            <topology evidence="10">Peripheral membrane protein</topology>
            <orientation evidence="10">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the taffazin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QU30"/>
    <dbReference type="OrthoDB" id="193467at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047184">
        <property type="term" value="F:1-acylglycerophosphocholine O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035965">
        <property type="term" value="P:cardiolipin acyl-chain remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000872">
        <property type="entry name" value="Tafazzin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497:SF0">
        <property type="entry name" value="TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12497">
        <property type="entry name" value="TAZ PROTEIN TAFAZZIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00979">
        <property type="entry name" value="TAFAZZIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="13">
        <location>
            <begin position="65"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU365062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW65299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="384" mass="43234" checksum="43B33492F54CF54E" modified="2019-01-16" version="1">MSTTTPAPHSPSLPWRLTSSFVMGLAGSLSRGFYFGLNNMEVIGLDRFLQTLDARKDVEGRERGLITVSNHVCVIDDPLVWGVLPMSYSFNPDNHRWSLGSYDICFKNKFMSSFFTFGQVLPTHRNAYSPEHGGLFQPTITQAIRLLSSQPFAERQLPVNSRPVSISPSSPDIIDPFSTGELTYSTNGVDVFPAPSAYSSRKHSWVHIFPEGRVHQHPQKTLRYFKWGVSRLILESEPLPEIVPMFIDGHQEVMAADRTWPRFVPRAGKNIKVVFGESVDGEKVFGDLRKRWQSLVKLQQEALVKKGLDSDMVLGELTDGLKYSKEVAELRKEVTKRVRMEVLKVRKSLGYSDEDPKEGLAETWIVEGGKQTGKMNDGSWVGET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUC0</accession>
    <name>A0A3D8QUC0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ubiquinol-cytochrome c chaperone domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_10091</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUC0"/>
    <dbReference type="OrthoDB" id="10253878at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034551">
        <property type="term" value="P:mitochondrial respiratory chain complex III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021150">
        <property type="entry name" value="Ubiq_cyt_c_chap"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007129">
        <property type="entry name" value="Ubiqinol_cyt_c_chaperone_CPB3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX ASSEMBLY FACTOR 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12184:SF1">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME-C REDUCTASE COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03981">
        <property type="entry name" value="Ubiq_cyt_C_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquinol-cytochrome c chaperone" evidence="3">
        <location>
            <begin position="145"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW65399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="323" mass="36420" checksum="29E51E7A5DBA430A" modified="2019-01-16" version="1">MASKACTTCLRTLQRHSRSLAQARRPVNLIATRSFNRHDIFQGELPDPSAKKQGSNQSGTPERTEGSSKVGTDPALNFKAAKELRRVAGKSMETYSAYGSTQHLYRMCSAQADYSIPQAQDEDAEMPKTEDGEDLGVGDGWWHTELGLNPTFSTWSQVTMLHMYLLATRFRCFESSESQIWQQHLLDHFFYEAEHKMTVNHNMHARGTRNKYLKDMFIQWRGLLAAYDEGIMKSDAVLAAAIWRNLFKANEDVDVRGLAQIVSYVRRSLRDLDALPEETVMEGDVQFSKPADEAKVVDIRSKMLDMPLDGVPSAPPNVPKTLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUW2</accession>
    <name>A0A3D8QUW2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Chloride channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_09976</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the chloride channel (TC 2.A.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUW2"/>
    <dbReference type="OrthoDB" id="44789at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005247">
        <property type="term" value="F:voltage-gated chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04591">
        <property type="entry name" value="CBS_pair_voltage-gated_CLC_euk_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03684">
        <property type="entry name" value="ClC_3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3080.10:FF:000011">
        <property type="entry name" value="Chloride channel protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3080.10">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014743">
        <property type="entry name" value="Cl-channel_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001807">
        <property type="entry name" value="ClC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45711:SF6">
        <property type="entry name" value="CHLORIDE CHANNEL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00654">
        <property type="entry name" value="Voltage_CLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00762">
        <property type="entry name" value="CLCHANNEL"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81340">
        <property type="entry name" value="Clc chloride channel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0129">CBS domain</keyword>
    <keyword evidence="7 9" id="KW-0868">Chloride</keyword>
    <keyword evidence="5 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="264"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="338"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="473"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="532"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="563"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="629"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="11">
        <location>
            <begin position="695"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="843"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW65284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="890" mass="97252" checksum="5373395D33C5A7AD" modified="2019-01-16" version="1">MASSSEGYFSPADQHSSSSSKSPSKRAIAEDDSDNDDPVASYTRDRNLLADDPLNAESGETVSFKRKQKQTVGSRFLASLTTSRQATPSPRSGTPNLSHGRSSSVHVNGGTGNGPLSSEGAKDGAPLDWYVEGPGRRVGYDNMTAIDWIFEYTKERQRLRMLYSSASGVVGYLQQALDASQIWVILICTGLLTGLVAAGIDVISVWLGDLKYGYCSAGEDSGRFYLNKAFCCLGYDELSQCQDWIPWSNAVHITSAGGTWFIEYFFFVLFSVSFALGACLLVQEYAIYAKHSGIPEIKTVLGGFVLRRFMGTWTLVVKSLGLCLAVASGMWLGKEGPLVHVACCCANLFMKLFSNINGNEARKREALSAAAAAGISVAFGSPIGGVLFSLEQLSYYFPDKTMWQSFVCAMTAAVTLQAFDPFRSGKLVLYQVTYSTGWHGFEMIPFAMLGIFGGLYGALFIKTNMKFAEWKRAATWLPGPIIQVVAVALVTALINYPNFYMKVQTSELVYSLFAECAKLTNDQFGLCKPGSATIGTIFLLLFAAILGFFLASVTFGLQIPAGIILPSMAIGALIGRAVGIIMEIWVHNNPTFFAFASCEPDIPCVTPGTYAIIGAAAALGGVTRMTVSIVVIMFELTGALTYVLPIMIAVMFSKWVGDAFGKKGIYESWIHFNEYPFLDNSDEIPIPDIPVSQIMTRIEDLVVLTATGHTIQSLAEILSTHPYRGFPVISNPREAILLGYISRAELTYNLHTSTQPPRLLPPDAEAFFSHQPMADPRTTLDLRPWMDQTPLTLPSKSNLLLTANYFQKLGLRYILFVDRGVLQGFLTKKDVWFILNGAEETRRTNGDDPLAMDTGLTRQDGQGEQRGLLNTEEEVDEVPMTPGIPHIPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUY9</accession>
    <name>A0A3D8QUY9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Luciferase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_10193</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NtaA/SnaA/DszA monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUY9"/>
    <dbReference type="OrthoDB" id="8922241at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.30">
        <property type="entry name" value="Luciferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051260">
        <property type="entry name" value="Diverse_substr_monoxygenases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011251">
        <property type="entry name" value="Luciferase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036661">
        <property type="entry name" value="Luciferase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016215">
        <property type="entry name" value="NTA_MOA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03860">
        <property type="entry name" value="FMN_nitrolo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011">
        <property type="entry name" value="ALKANESULFONATE MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30011:SF30">
        <property type="entry name" value="XENOBIOTIC COMPOUND MONOOXYGENASE, DSZA FAMILY (AFU_ORTHOLOGUE AFUA_6G01920)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00296">
        <property type="entry name" value="Bac_luciferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000337">
        <property type="entry name" value="NTA_MOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51679">
        <property type="entry name" value="Bacterial luciferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Luciferase-like" evidence="2">
        <location>
            <begin position="38"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00033748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW65501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="491" mass="54346" checksum="5007611B63CCBBA7" modified="2019-01-16" version="1">MASPTAPKARKQIHLNFFETACTGNHECAGQWARPGDNAHTKDRLAYYLWLAKLADKARITCIFFADTYAGHEIYGGNMDAVFRAGAQVAQLDPLVIIPAMAAVTENVAFGVTGSTTYIPPFPMARTFSTLDHLTEGRVAWNVVTSWSQAAANAFGMELQPHDKRYEIAQEYMDVMYRLWQGSWADDAVRFDKDKKTAYEPSRIKKIEHEGEYLKMSARHQMHPSPQRTPVIFQAGTSKAGQAFAAKHAEAVYIGGLEPNQAAYQIKAAREMAASMGRDPTAIKFFAAITPFIGRTLEEAQAKFAEAEKYADIIGGLGQFSGYTGIDMSKYPMDEEFKLDSSIPTENAVQAFLGNFTDSVKFGVKVPWTPRRLGMKIALGGFHPSPVGTPEMVADEMERWVDEADVDGFNIAYVSNPGSFEDVAELLRPELLRRGLVFEDYAVPGGTFRENLLRQPGQRTLRSDHYGSGFKFEGEEAGVLNGTAVEEKLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QY20</accession>
    <name>A0A3D8QY20_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_09428</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QY20"/>
    <dbReference type="OrthoDB" id="5376138at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000088">
        <property type="entry name" value="MFS multidrug transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF13">
        <property type="entry name" value="MULTIDRUG TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G12550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="156"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="430"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="499"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="90"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="538"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="538"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="597"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="613"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW66679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="626" mass="69648" checksum="09CC6048A0BEF7AE" modified="2019-01-16" version="1">MATVPGAGDHAEQLSEKPRHVETDDSSQTKLESADDEHTETVAPKASRHAQFDPNALASKLEKEERHELTEDECYDELGFRFPTWKKWMILSIIFIVQVSMNFNTSLYSNALTGISEEFHVSLQAARCGAMVFLVLYAFGCELWAPWSEELGRKPVLQASLFLVNIFQLPVALAHNFGTVMAGRALGGLSSAGGSVTLGMIADMWESDEQQYAVAFVVFSSVGGSVLGPVVGGFVEAFLPWRWCIWIQLIFGGFVQLLHLFLVPETRTTVLMDRIAKKRRAAGGPGSNVWGPTEGLSFKERFPPKEIIATWVRPFKMFLTEPIVLTLSLLSGFSDALIFMFIQSFSLVYKQYGFGTVELGLSFLPILVGYFIAWIAFIPFIRRNIRQRAEKPDDEQVQYESRLFGLLFMAPCLPLGLIGFAWTIQPQVPWIASMIFAALIGIANYSIYMATIDYMICAYGPYSASATGGNGWSRDFLAGVLTIPATPFFTNIPGRPLEYANTILACISFVLIIAVYVIYWKGPSLRKRSPFAEQLKDRNAVQTEHDQKPLSRHPSKTHPAIPGQARPLAGRSQSYSRAQQEARLRQATGSRHHSGRNSRNNSQPGSAAVSRQHSLERINRQAAEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYH1</accession>
    <name>A0A3D8QYH1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09622</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYH1"/>
    <dbReference type="OrthoDB" id="10427175at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW66873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="339" mass="37337" checksum="2C649796EE330014" modified="2019-01-16" version="1">MKLDIRNITTQSRLRRKTVRAQEGSEKGMNTPPTGPTTFASSTDATLLPTPSSSSPSNQQVWDDSDGELSDVDESIFGPDVFQALCPGLHKQQENRHVSPYSSMSSTDLPQALKIIEPTASSMCLNQSYDSEPEPSNASPQVRSSFLEKEDRVKRPSREDQDNLCWKFNQLEIPGVEVNDAGMRTKSSKFLPNKALTRTTSLSGRLVVKPQPDSYPLLSRLPARNNSKASLDLQPSELSRAFGADEIGNISGPHTDLLSLKSLVHGAYFYFHTQPWTYSFDYKAARSLPATTSTEEDLILITTATFLNLSRRHPATLLDYSVPVSSAEACEALIHALST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYQ6</accession>
    <name>A0A3D8QYQ6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAD dependent oxidoreductase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_09668</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYQ6"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847:SF185">
        <property type="entry name" value="FAD DEPENDENT OXIDOREDUCTASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_3G02360)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13847">
        <property type="entry name" value="SARCOSINE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="2">
        <location>
            <begin position="6"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW66919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="437" mass="47175" checksum="F220DCC752CB44B4" modified="2019-01-16" version="1">MVDNTVILGAGIIGVATAYYLSSSQNPKSIHLVEPSPKLFASASGNAGGFLAADWFTSSVAELGRLSFDEHRRIAEEFNGREKWGYSRSTSISLSPGRESQRATRADDWLRQGESREFAASARDNEQVGGDGWEPDWLRNGEGDTMEMISEEDNTAQVWVRTIIAPSSSTTLMALTLRTTSDPFRLSQFLLERCLERGVQLHHPAKAISIGKDVRDELASICILDTTTNTETDIPCFKLLIAAGVWSPRVFSDLFTTSEFCVPAQSLAGHSLVVKSPRWTSTMEGKSCHAIFTRDPQGYSPEVFSRLGGEIYIAGLNSDAIPVPELATASTINENAIIALLATSRRLLGRSHDDAEIEILRKGLCFRPVTKKGTPILSKIADQSLGGVNTRPDGEGGVFLAAGHGPWGITLGLGTGKVMAGIIQGKTVSADVSRLSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYX4</accession>
    <name>A0A3D8QYX4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD40 repeat-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_09620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYX4"/>
    <dbReference type="OrthoDB" id="10261640at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000643">
        <property type="entry name" value="60S ribosome biogenesis protein Sqt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051179">
        <property type="entry name" value="WD_repeat_multifunction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857:SF8">
        <property type="entry name" value="ANGIO-ASSOCIATED MIGRATORY CELL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="139"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="237"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="338"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW66871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="518" mass="53555" checksum="2435846CCF10C746" modified="2019-01-16" version="1">MASSHQNPNEDGDVYDHDEPAMLDPNEAGEEIEDDGDAAMDSGSEGEDGGDNDEIMQEIQLENDSSAHFDAHKDSIFTIAQHPLYPNIVATGGSEGEDLGGIGYIFDSTPDAAPVLPASYQTSPGEPVERKSLSPIFTLEGHTDSINALTFTLPNGEFLLSGGLDGKLRAYASPKGKVQPWKFLAEAQEVEEVNWMVPCPNPAYPNTIALGANDGSVWVYTVDMSSKDAPLQIVQSYFLHMESCTAGAWTADGKMLATVSEEGSLYVWDVFGEAAMAGLTQENGQTVVGLTAVDQRFAVEGGLFSVAVAPSGAFVVVGGAGGSIKVVGLPRLSAEASGAAPAGRGGAGAASKGKGGKQTGGKASGGAAAAGQAGQILADLQAQTDGIESLAFAPPPLTLLAAGSVDGSIALFDSAHRFAVRRHIKEAHEEHSIVKVEFVQNARTGGWLLTSCGMDGVVRRWDTRGGTGMANSGFVAEWRGHRGDGEGGGVLGFVQGDGTRIVTAGDDGVSLVFESPLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QZ53</accession>
    <name>A0A3D8QZ53_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">General substrate transporter-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_09784</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW67035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QZ53"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000090">
        <property type="entry name" value="MFS sugar transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF72">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="172"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="298"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="332"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="358"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="396"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="15"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW67035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="489" mass="54451" checksum="EE7A4E94FB2E9814" modified="2019-01-16" version="1">MRSWFGRGKSLRLAVSGCCLLAFTLFGYDQGVFGGILQNQNWLHQFGNPDATITGIIVSSYNLGCLLGCCINFVIGNPFGRRKVIWLAASTIIVGAILQASAYSLAHLIIGRIVTGMGTGLETSTVPMYQSELCQAHMRGRLVSAEVLFVGVGITIAYWFDFGMSFTSGSIAWRLPLAMQIIFAVFVIALVFGLPESPRWLYNHDRAEEAVQVLCTIYDKPSTDEVIVHETSQIMEAIELEERTGKFQWRNILKRDSVRTGRRVLLAWGIQFMNQAGGINLVVYYIPSVLVQNVGMSAQLAQILGGCINMMFMFGSLIPTFFLDRMGRRKTMFWGCAGLGISMMMISILLSIKRASTASASVAFFFTYMLIFGASVNCVPWVYVPEILPLEARAKGTAVGISSNWLWNFTIVMITPVLISRLQWKAYLIFMATNFAFIPVIYFFYPETSNKTLEDIDFLFMDGGADSLSQLRKSGPKIDIEKGELQEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QZG0</accession>
    <name>A0A3D8QZG0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_09800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW67051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QZG0"/>
    <dbReference type="OrthoDB" id="1668230at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="14"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW67051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="270" mass="30678" checksum="12561CE22A1F91F6" modified="2019-01-16" version="1">MVPPQIESTSVLHLSQLEEVGSGLNSTVYKLKGSKIVVKVPRQNSMLHHEVERSIYERFERLPSNANILKYLGETKVERSNATVFAPGLLFEYHPEGILRDVLETNLAPPPADYQKLRFSTDLASALVFVHSCHVVHGDIGLHNILFSREPHARMILADFGGSRIDQSQFLSWPSARYRMEGRDYQSGETYEPTEQHDIFALGMVIYEIMTWSQAWKGKEHPEVLALIRQQQFPDLQLVTLKAMEEVIGNCWGRQYVVASDLLSDLEGMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QZJ3</accession>
    <name>A0A3D8QZJ3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_09743</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QZJ3"/>
    <dbReference type="OrthoDB" id="5370478at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050815">
        <property type="entry name" value="TF_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338:SF27">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47338">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0843">Virulence</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="8">
        <location>
            <begin position="28"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW66994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="653" mass="74056" checksum="5CC3E204FA23B22B" modified="2019-01-16" version="1">MAELVPEEKNVKRKRDEDDTAQRRTPRACLPCRKRKVKCSGTRPCCENCLRLHDKCHWGTECHNLRAGSGQTPNSPPPVEKFLSRQQHDVLIKIFFKTPHFDILRQCIHRPSFEAKEITQHCPFLLVSIYCVSALYVSNENVREVFHGEEPADLSARLVVLARQWSRDTSDQPCVPSIQGNLILAFRELLCRTGYKSWMFTGIAIRMTQALRLHREYHQRHSSLEQEVRRRTMWACFIMDRLVAHVTGRPYTFRTKKLTAKLPSAESAFLFEETSSSTLSAATIESGPSPECTEVLPFFIKAVDLWSVMTDLFAGGVKSTSTIGAASPNHEFYRAEQELRTWKENLPARMKWSMKNYRTHRVLGQGSLFVSLHFVLNHAFCVAHQEYLPDANSDMTITSSEIEETPNITATCLYHADEITRMASSLHIGDATDMEMLRAPFVGVALECAACCHLWTIHQESSETDMELTSKATASKQKLRLLCDMLKSWSAVWPIAAAWYETIELLTKLYDAVRPGGSPLIESSSDDAAEDVPPGCTDVALGSGLPDPRNTAYAERLFDQIRHIAMTATETSGLRHRQTRLWIENLWTHTWLKGQPAMSEAAIGKYSMVAGDFSNFENVLDFMDGFEAFEDFTNASYVQGDQPHLLPYPWDMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R2U0</accession>
    <name>A0A3D8R2U0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein S15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_09016</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R2U0"/>
    <dbReference type="OrthoDB" id="441444at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005290">
        <property type="entry name" value="Ribosomal_uS15_bac-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15, BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23321:SF26">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW68359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="309" mass="34110" checksum="5FBCE4B2DBEB74F2" modified="2019-01-16" version="1">MPPRIPSVARLSVTSLCFRPSPSNGPSTIAAIANASSLSQAQKKRHRDPYAIAQAKQRKAANIQRQAQLKQERDQALGDPVKGIETPFLKSFDTAGNVDATSADGMPIKSVHDSPLNHFLTATELEKSLQHSYELSKPVISEIRDTADPAVEKVLAIAHAAGHERAVTALERITSLANASRKDKTRVNVRRCIETFGRHQTDAVLKPKAPVAKILDGQPEKTPRAGPDTGSSEVQIAILTAKIRVLAHQLEQKGEQKDKTNKRNLRLLVHRRQKHLRYLRTKERGSERWQHLVSTLGLSDGTWKGEISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R2W1</accession>
    <name>A0A3D8R2W1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_08955</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R2W1"/>
    <dbReference type="OrthoDB" id="5296287at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000313">
        <property type="entry name" value="MFS quinate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF8">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="163"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="295"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="474"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="30"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW68298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="561" mass="60738" checksum="BDBE474046B7AFFB" modified="2019-01-16" version="1">MGGQPIGPGMFKAAMADTPREALNWRLAFSVVCFGLMGAARGLDEGLISTTIAQKSFIAEYGLKTSKTLSAAELAQKQGNITAMVQIGSVAGALIAFIACDKIGRIWATRQLCLIWIIGTIVYITANGNYGQILAGRFVMGLGIGQTTVVAPAYLAEIAPRSIRGLCICIFSGAVYLGIMLGYFANWGTSLHISNNSADQWIDATVMHIIFAGIILIMSLFALESPRWLAKIGKDEQASINMSKLRQLPADHPYVRAELIDIHDQLDREREATLGSGFFGPLKELFILPSNRYRIMLGLMCQLLGQWSGGNSITIYAPSFFALLGTTGQSEKLFATAIFGVVKLVSSLICAFFLVDFLGRKRALSIGIILQFISMTYIAIYLTAVPAITSGGVRSESAKHAGAGAIVFIYFSGVGWALGWNSIQYLIGAEIFPLRVRSLGTSMIMTFHFVNQYGNSKAVPIMLLKDQMKPQGTFWFFSAVTLLGLAFTYFFLPETAGKSLEGMDELFSLPWHLIGRKGQELTAGSGSVAEAVARGDTEKVAYIEQAEHAENAETAPNTQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R309</accession>
    <name>A0A3D8R309_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Presequence protease, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Pitrilysin metalloproteinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BP5796_09090</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Degrades mitochondrial transit peptides after their cleavage in the intermembrane space or in the matrix, and presequence peptides; clearance of these peptides is required to keep the presequence processing machinery running. Preferentially cleaves the N-terminal side of paired basic amino acid residues. Also degrades other unstructured peptides. May function as an ATP-dependent peptidase as opposed to a metalloendopeptidase.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer and homodimer; homodimerization is induced by binding of the substrate.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion intermembrane space</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase M16 family. PreP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R309"/>
    <dbReference type="OrthoDB" id="10250783at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000020">
        <property type="entry name" value="Mitochondrial presequence protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000009">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000011">
        <property type="entry name" value="Presequence protease, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013578">
        <property type="entry name" value="Peptidase_M16C_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055130">
        <property type="entry name" value="PreP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF13">
        <property type="entry name" value="PRESEQUENCE PROTEASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08367">
        <property type="entry name" value="M16C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22516">
        <property type="entry name" value="PreP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01264">
        <property type="entry name" value="M16C_associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7 17" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16C associated" evidence="16">
        <location>
            <begin position="518"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1037"/>
            <end position="1063"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00020167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDW68433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1063" mass="117622" checksum="8F6F137D41B96B07" modified="2019-01-16" version="1">MFTRWAPFLAPSASIPHPPPAPQHSSCQVVRMLRNATKGPIRKGVTELAQYPKPGEKLHGFTLLRSKHVPELELTALHLQHDKTGADYLHIAREDKNNVFSIGFKTNPPDDTGVPHILEHTTLCGSEKYPIRDPFFKMLPRTLSNFLNAFTASDHTFYPFATTNEQDFKNLMSVYLDATLHPLLKQSDFTQEGWRIGPENPRVAEGKDTKPEDSELVFKGVVYNEMKGQMSDASYLYYIRFQDHIFPAINNSGGDPQKMTDLTYEQLKKFHAEHYHPSNSKVFTYGDMPLADHLREVNAQLDSFGRIEGDMEIRRPVDLSGGPQEITVTGPIDPLVDMDMQFKTSTSWLMGESSNILETFSLGILAALLMDGYGSPLYRNLIEAGLGTEWSPNSGFDGSGAVGIFSIGLTGVKEADVPKVKEAIHKTFQEVHQNGFDKTKIDGYLHQLELSLKHKTAKFGMRLMQRIKPKWFEGVDPFESLAWNDTVAAFEAEFAKGGYLEGLLEKYLLNDNTLTFTMAPSATYSDELVAEEASRLAGKIEEVTIQAGGEAEARAQLEKRELELLEEQGKSNTQDLSCLPTVYVKDIPRQKEKIEVRDSKIDGVNVQWREAPTNGLTYFRAVNTIENLPDELRALIPLFSDCIMRLGTKDMSMEQLEDLMKLKTGGVTAGYHTSSSPLDYQKATEGLSFSGTALDRNVPDMFQLLRKLVLETDFDSAEAQLRIRQLLQGSADGAVNNIASSGHGYAKGYAESGISAYGRLKEQVGGLTQVQLITSLASRPEAEGLADVVEKLKAIQRMAFSGSNTFRTALTCGTESVGANEAALQKFLASLPQNSSPSASKAGSTDFARNSKTFFPLPYQVYYGSLALPAASFTSPSGPPLQILAQLLTHKHLHHEIREKGGAYGGGAYSRGLDGVFGFYSYRDPNPQNTMTIMRNAGQWAVEKEWSERDLEEAKLSVFQSVDAPQGVSDEGMTRFLSGVTDEMVQERRERMLDVTKDQVRAAAQQFIVDGLAQNQGRTVFLGEKKAWVDGSWELREMGSISQPQPEPGTQDEAQAKAAALGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R312</accession>
    <name>A0A3D8R312_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase III subunit RPC9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_09023</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC9 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R312"/>
    <dbReference type="OrthoDB" id="1746530at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038846">
        <property type="entry name" value="RPC9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561">
        <property type="entry name" value="CALCITONIN GENE-RELATED PEPTIDE-RECEPTOR COMPONENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="8">
        <location>
            <begin position="45"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="23"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="23"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW68366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="201" mass="22902" checksum="E55793279777AD92" modified="2019-01-16" version="1">MKILEAQSAILTNFEVYQHLKSQNEKHAALKKSTEKRLRKENDAKRKRTGKSGQMTSSETFDLRNAIKDVTRRPGNLETVVREILEFLEEAPSPLASKPLPYDENTIRKLMERLRSYDLTKAELLMLMNIRPTNLEGLNVIIQELDLRFPEEATQFELVSAVVEILGTPDVEANKQAMTDAKEAKQAEEAQASTEMEVVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7T9</accession>
    <name>A0A3D8R7T9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF410-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_08510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GET4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7T9"/>
    <dbReference type="OrthoDB" id="10252405at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072380">
        <property type="term" value="C:TRC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000272">
        <property type="entry name" value="DUF410 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007317">
        <property type="entry name" value="GET4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875:SF0">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04190">
        <property type="entry name" value="GET4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="304"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW70113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="328" mass="36467" checksum="7FC887D5A459CBF6" modified="2019-01-16" version="1">MSAKIEKIIVRLQQKTTEGQYYEAQQQTRVVAARYIKQENWDAAIDILYNVAQSLLKAEQGGSGGDLSLMLLDVYKQAQLKPDAANKGKLLTLLRLFDSEEPTRKQFITEMIVWSAKCGDYPAGEPELHHVAGSLYAEEHEAYEAERHLALGTKDSPDVFAKLEYEWYTQDDSHTAALYAARAVFPYLLTGNIRDASKSLRLFTSRLTEANKNLSVQDVSSTSSDLRIYPSLPLLNFLGLLLLAVQKGSADLFRQLKSKYASHIKEAGTWDEALTTVAEMYFGIQRPRQGNPLFDMMGSMFGVPGAAGPKQPQTRRVEAPAPAAEGLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R821</accession>
    <name>A0A3D8R821_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08455</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R821"/>
    <dbReference type="OrthoDB" id="5413827at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790:SF4">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38790">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="444"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW70058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="483" mass="54079" checksum="272856AAD2D3292D" modified="2019-01-16" version="1">MPRKKLIAASNRKKERDVVATAASDSKARASPLSTLTFAPTTEAKNTQNKPALLNLPAEVLDRILKYAVAFDGPIKPHQVCPKSNKFTWNDAQKHLCGELSAALPPLVAVQLSSVCKDLYLLVSTGHMFYEVNEFSFGQSGDLVKYLMAITPDRMKAIRSLHCVWYQQGCKDVFTSLAACSGLRKLDLVIQNGGGYGIIEQDLSKRAGFHDLVLAVRGLKTLTLTAAETFMYTSQGFIQTPERKIDTLHPSLLEAIAKPRTSIWIPTGKLQSARQVANLDVHGEGRITGDRKPDTVSSRTRQQNYRTIDNNGVLRPATLAKYSVSGMLAWDVIRILDSRSSISMEGMPSIEFLVECYTAANLYSRFEDNREVFWEDVTMLDPVRTSLMIVEFFKEHRKAEGKEIVHSIWKNAYDEDGVSFKSKHWAPVTLSRLIEQEDLRVQKEAHRAAARAAHKAAKDRLKKEKSKESHRKKAGRSMGQTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8C7</accession>
    <name>A0A3D8R8C7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_08578</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8C7"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF283">
        <property type="entry name" value="RETINOL DEHYDROGENASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW70181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="346" mass="37861" checksum="69C794D9F03D845E" modified="2019-01-16" version="1">MASTTYSAFGAKSTATEVASAFGAEIEGKAVLITGVGPKGLGEALALAIAAHNPRLLVLASRTIAKLQLVEDKIRFIAPKALVQKIQVDLSSQKSVRYAATEIIQILREKDFKLDVLINNAGINVSTRQLSPEGIELQFATNHVGPFLLTNLVLQHLSPVGRVVNVSSEGHRASGVRFSDWNFEPGKVVAEAEKPNERLREMGFLKGGDGYEVWLAYGQSKTANILFAVALNERFGKGTEMGRRAFACHPGNIWTEFVRDMDQEALKKLETSIADNWKTADQGAATMLVAAFDPKLQHQNVTYMDDCQPRRPARWAGDAAKAEQLWELSESLVGERFGLGQRQGRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8I9</accession>
    <name>A0A3D8R8I9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">2-oxoglutarate reductase</fullName>
            <ecNumber evidence="4">1.1.1.399</ecNumber>
            <ecNumber evidence="5">1.1.1.95</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BP5796_08638</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>(2R)-3-phosphoglycerate + NAD(+) = 3-phosphooxypyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12641"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:18110"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="EC" id="1.1.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>(R)-2-hydroxyglutarate + NAD(+) = 2-oxoglutarate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:49612"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15801"/>
            <dbReference type="ChEBI" id="CHEBI:16810"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.399"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-serine biosynthesis; L-serine from 3-phospho-D-glycerate: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 14">Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.399" evidence="4"/>
    <dbReference type="EC" id="1.1.1.95" evidence="5"/>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8I9"/>
    <dbReference type="OrthoDB" id="1621027at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061759">
        <property type="term" value="F:2-oxoglutarate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004617">
        <property type="term" value="F:phosphoglycerate dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006564">
        <property type="term" value="P:L-serine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12176">
        <property type="entry name" value="PGDH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.260:FF:000036">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000041">
        <property type="entry name" value="D-3-phosphoglycerate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045865">
        <property type="entry name" value="ACT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050857">
        <property type="entry name" value="D-2-hydroxyacid_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006139">
        <property type="entry name" value="D-isomer_2_OHA_DH_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029753">
        <property type="entry name" value="D-isomer_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006140">
        <property type="entry name" value="D-isomer_DH_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008759">
        <property type="entry name" value="PRK11790.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42789:SF1">
        <property type="entry name" value="D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10090)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00389">
        <property type="entry name" value="2-Hacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02826">
        <property type="entry name" value="2-Hacid_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55021">
        <property type="entry name" value="ACT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00671">
        <property type="entry name" value="D_2_HYDROXYACID_DH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0520">NAD</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0718">Serine biosynthesis</keyword>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase catalytic" evidence="15">
        <location>
            <begin position="64"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding" evidence="16">
        <location>
            <begin position="168"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005854"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDW70241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="471" mass="51528" checksum="DEB1ADA8162D071F" modified="2019-01-16" version="1">MATPAQDIAISPNRLARTVSNSLSVSPTATFHSPPNSFGGAGFMRTRTTGEKQLKPFDTQDIKILLLENVNESGREKLAEQGYQVEALKTSLPEDELIEKIRDVHVIGIRSKTKLNERVLREAKNLIVVGCFCIGTNQVDLEYAAKHGIAVFNSPFANSRSVAELVIAEIIVLARQLGDRSNELHNGTWNKVSSGCWEIRGKTLGIIGYGHIGSQLSVLAEAMGMSVIYYDVVNLMALGTATQVPTLERLLNEADFVTCHVPELPETKNMISALQFEQMKKGSYLINASRGSVIDIPALINASRSGKIAGAALDVYPSEPAANGDYFTNSLNQWAEELRSLKNIILSPHIGGSTEEAQRAIGFEVSEALIRYVNSGATLGAVNLPEVTLRSLTLEERNHARIIYIHHNVPGVLRKVNEILGDHNVDKQITDNKNEVAYLMADISNVNSSDIKEISDNLEGLSSRILTRVLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8S2</accession>
    <name>A0A3D8R8S2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08783</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8S2"/>
    <dbReference type="OrthoDB" id="3522351at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="47"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="114"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW70386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="189" mass="20649" checksum="7EB93E0B42AD22D4" modified="2019-01-16" version="1">MIVIGALLRLSEAHDGFANAPKDSIFPASVQRFLITTDVLSGSAWSFLWSVIPTLTFTLFSLYWGVIVSDLQDRQPFVELGSGKGGNGKQTVLLDYRQSFGLIRWFRAFQNGHYILGVALVLQIIVSFALVPLASHLFVASDIVRATGTNMLVTMSFNGSAFNSKSDITSILSLVSATRNLNASFPPWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCE6</accession>
    <name>A0A3D8RCE6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_07746</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RCE6"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF210">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="4">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="28"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW71712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="629" mass="68161" checksum="526BED182375B71F" modified="2019-01-16" version="1">MAATTPTPDPMGFLASERFDFIIVGGGTSGLVVASRLSEDPKVNVLVLEAGPDRLDDPRITTPGFAPQTYNNPDFDWRFMSTPQEHLDGRQIAQPKGRILGGSTAINLGMAIYPSKSGVNAWEQLGNPGWGWDSFSPYLKKFHTLTLPSAKTQEELALGYVKGNDHGTNGPIQLSFGEMDVYTPFNSAWPRTFSTLGHNLTGDPISGVANGAFQNPGVVDPVSKKRSHAGSTYYNTEVGARPNLFVVTEVLVEKILIQNNNGALSATGVQITTKDGSKREVLATKEVVIAAGTIKAPQLLELSGIGSKALLSQHGIETLVDNPNVGENFQDHGYVPFSWEIADDQLSGDSLRDPNIAAAATSAYMQAGAGPFSGVPIASSFMPLTDLSDAERTELLAKYLDASDYKSVPSQDQQFGLLRDILNDPNDASGQYTMAPFQIVPRDGPHLDKIYGMGKEGNYISIVSVLNHPYSRGHCHIGSADPTAHPVVDPRYFSHPLDLELHARHTQYLETLAATEPMASLLKKDGRRIHFHKKVETLDEARQVTKETFISHYHVVGTCAMLPEKIGGVVNERLQVYGVSKLRIVDASVIPLIPRGNIQATVYAMAEKAADIIKEDYALAQRGGQNFIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCH9</accession>
    <name>A0A3D8RCH9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2EXR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_07791</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RCH9"/>
    <dbReference type="OrthoDB" id="3438006at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045518">
        <property type="entry name" value="2EXR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35910:SF6">
        <property type="entry name" value="2EXR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20150">
        <property type="entry name" value="2EXR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="2EXR" evidence="2">
        <location>
            <begin position="197"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW71757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="475" mass="52798" checksum="179F46115750864F" modified="2019-01-16" version="1">MTDRTNSSNGSADLTELGDHQTSSATYDRAGPIELTAPGSSTATHDHAGPIELTAPKSSTATHGQAGPIELAIPKFSTATHDQAGPIEPATTEASTSSNDQAGLSEPATPDSSTSSNDQAGPIVRATPESSTSSNGGNSYPVQLMSGPAVMYFYQLGYIDLPFPGPNNIFNYELAFQDLPTSEPSDTNNHQAELTEFPLFANFPPEICIKIWHAVAIQSRVVPVTYRKSYCEVTQIPEGSEFISNEGVPAILHVNRKARQIGLMHYQLVLPTRTAPATIYVNLAYDLIYFNKVDTQLIDGIPDNSSPLFGMLDDCDVGDCWKIPQLAIDWMLWDRELDINAHRFHHLRYLWKLFVVREIETIDLPRTTTSDSMSTRKLMDPTMPALGYDQQVVDYNEQCEANHWVTNVLTDLRWLRVDVRDAVDHLPAALAAQTMMQTNRLLANTEPMYLLPQGRYNRLMEMFMRWWTAGSRVTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCL5</accession>
    <name>A0A3D8RCL5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">Nitrite reductase [NAD(P)H]</fullName>
            <ecNumber evidence="19">1.7.1.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="23" type="ORF">BP5796_07816</name>
    </gene>
    <organism evidence="23 24">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="23 24" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23 24">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>NH4(+) + 3 NAD(+) + 2 H2O = nitrite + 3 NADH + 5 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24628"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.7.1.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>NH4(+) + 3 NADP(+) + 2 H2O = nitrite + 3 NADPH + 5 H(+)</text>
            <dbReference type="Rhea" id="RHEA:24632"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16301"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.7.1.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="16">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>siroheme</name>
            <dbReference type="ChEBI" id="CHEBI:60052"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Nitrogen metabolism; nitrate reduction (assimilation).</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the nitrite and sulfite reductase 4Fe-4S domain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="23">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.7.1.4" evidence="19"/>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RCL5"/>
    <dbReference type="OrthoDB" id="432169at2759"/>
    <dbReference type="UniPathway" id="UPA00653"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008942">
        <property type="term" value="F:nitrite reductase [NAD(P)H] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015980">
        <property type="term" value="P:energy derivation by oxidation of organic compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042128">
        <property type="term" value="P:nitrate assimilation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd19944">
        <property type="entry name" value="NirB_Fer2_BFD-like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03529">
        <property type="entry name" value="Rieske_NirD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.413.10:FF:000007">
        <property type="entry name" value="Nitrite reductase [NAD(P)H] large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1100:FF:000002">
        <property type="entry name" value="Nitrite reductase large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.480.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1100">
        <property type="entry name" value="BFD-like [2Fe-2S]-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.413.10">
        <property type="entry name" value="Sulfite Reductase Hemoprotein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007419">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041854">
        <property type="entry name" value="BFD-like_2Fe2S-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052034">
        <property type="entry name" value="NasD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005117">
        <property type="entry name" value="NiRdtase/SiRdtase_haem-b_fer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036136">
        <property type="entry name" value="Nit/Sulf_reduc_fer-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006067">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045854">
        <property type="entry name" value="NO2/SO3_Rdtase_4Fe4S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006066">
        <property type="entry name" value="NO2/SO3_Rdtase_FeS/sirohaem_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012748">
        <property type="entry name" value="Rieske-like_NirD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02378">
        <property type="entry name" value="nirD_assim_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43809">
        <property type="entry name" value="NITRITE REDUCTASE (NADH) LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43809:SF1">
        <property type="entry name" value="NITRITE REDUCTASE (NADH) LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04324">
        <property type="entry name" value="Fer2_BFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01077">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03460">
        <property type="entry name" value="NIR_SIR_ferr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13806">
        <property type="entry name" value="Rieske_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00397">
        <property type="entry name" value="SIROHAEM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56014">
        <property type="entry name" value="Nitrite and sulphite reductase 4Fe-4S domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55124">
        <property type="entry name" value="Nitrite/Sulfite reductase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00365">
        <property type="entry name" value="NIR_SIR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0274">FAD</keyword>
    <keyword evidence="8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="13" id="KW-0408">Iron</keyword>
    <keyword evidence="14" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-0534">Nitrate assimilation</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="24" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rieske" evidence="22">
        <location>
            <begin position="940"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="21">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005096"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00050114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00051413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00066907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00070300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="EMBL" id="RDW71782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1109" mass="122250" checksum="FB6ED3EADE76A8D2" modified="2019-01-16" version="1">MSSNWQPQVPIEEIKAGPIEGGPDGVKGSENDSHGGPRKKIVVVGLGMVGISFIEKIMKLDAKRREYDIIVIGEESHLAYNRVGLTSFFQHRKVENLYLNPREWYSNVPEGSLNYHLNTRVIEIHTKHKLVSCSSGETVPYDILVLATGSDALVPKHTPGHDANGVFVYRTIEDLENLISWSKERKGTCGAVVGGGLLGLEAAKAMMDLEAFKKVKLIERNRWVLSRQLDSDAGGLVVEQVQDLGLDVLLSKRVGKIEVTEDNAVKGVVFEDGERMDCSTICFAIGIKARDELARKAGIQCADRGGGIIVKDDLSTSVEDVYAIGECASWENQTFGLIAPGVEMADVLSFNLTQAKVHSYRKFKRPDLSTKLKLLGVEVASFGDFFADRDGPKHMPARAAKKRAESQNAVKTLTDGPPPSPVKALTYKDPFQNIYKKYLFTLDGKYLLGGMMIGDTKDYVKLVPMVKNQKMLDVPPSQFILGASKEGDDGGEDLDDDTQICSCHNVTKGDVVHTVKNGTCKSIGDVKSCTKAGTGCGGCMPLVTSIFNTQMKAMGQEVKNHICPHFNYSRADLYNIISVKKLKTLADVMKEAGNDPESLGCEACKPSIGSIFASLYNQHVMDKPVHGLQETNDRYLGNIQRNGTYSVVPRVSAGEITPDKLIVIGNVAKKYSLYTKITGGQRIDMFGAKKQDLIPIWKELIAGGMESGHAYAKSLRTVKSCVGTTWCRYGIGDSVGMAVRLEERYKSIRGPHKMKGGVSGCVRECAEAQNKDFGLIATEKGFNLFVGGNGGASPRHSELLAKDVPPDDVVPILDRYLMFYIRTADKLQRTARWLEALPGGINYLRQVVLEDKLGICASLEAQMEELVGTFFDEWAEAIKDPERAKKFQQFDNTTETLQNMDTEVDRGQERPVYWAKESVKEDFKNTKWTSLTWQPIIEASHFAGAEQSPNGISATIKRSDTQLAIFKVRGKYLASQQMCPHKRAFVLSDGLIGDSGDQLWVSCPNHKRNFELNGEQAGRCQNDEEVSIATFPVEERDDGWVYLKLPPVHELDGVLGTSRWMVKKGESGASPFEKLDKRIGLNGTRMKGRKPMEAKRTLVAAGNEGGIDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RD34</accession>
    <name>A0A3D8RD34_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="9">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BP5796_07914</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. UvrD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="9"/>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RD34"/>
    <dbReference type="OrthoDB" id="1470711at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17932">
        <property type="entry name" value="DEXQc_UvrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18807">
        <property type="entry name" value="SF1_C_UvrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.486.10:FF:000011">
        <property type="entry name" value="ATP-depentend DNA helicase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.486.10">
        <property type="entry name" value="PCRA, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013986">
        <property type="entry name" value="DExx_box_DNA_helicase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070:SF2">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE SRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 11 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="13">
        <location>
            <begin position="8"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="14">
        <location>
            <begin position="281"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="785"/>
            <end position="848"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="907"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="973"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1081"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="791"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="973"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1004"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="29"/>
            <end position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDW71880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1100" mass="121829" checksum="543175DEF13865A2" modified="2019-01-16" version="1">MSFDHVLANLNSSQHAAVSSFADTLAILAGPGSGKTHTLTSRTAWLLHQGLQPWNIIVATFTVKAAREMKERIGKLIGNGLESKLVLGTFHSISRRYLARYGHLIDIKKDFGIADSADSLAIIKRIIKRHNLNIDPGAARSRISSRKAKGDHYVEAKHPAKSVDIQEFETCWTEYEEALKRSNLLDYDDLLLRCVQLLRTHPSCVSNVEAVLIDEFQDTNIVQFDLMRLFATQRKRITIVGDPDQSIYGFRSAETKNFKRLLRQYPETVTIALEENYRSSGAILLTALGVIEQDTSRIAKSLMPTHTVGTKPVLRKLGNAHKEAGWLVSEIQRCLGLTGTLLDGNDFAILLRSAALSRLIESALGKAGIAYRMVGGHRFYDRVEVKIILDYLRVINQPDNNDALARIINVPSRRIGETTVKAMLEEAEQSSTTLWSLLLDTAQGNRTMKTKLGKEADRNIGIFIDLVLKARKKIAACPDQKYSTVELIDYVVSKSRFEDFLEKKYSEDHESRWANIQELRIQATDFEAQLSEEDEEALPEIDGLEQDGSSNPLSKFLANVALASEVKKDDDGPEAPQVTISTIHAAKGLEWPIVFIPAAYQGSIPHSRAEDSDEERRLLYVAMTRAKALLYISLPLKNSQGEETTLSPFLSPLSLSPLLDKQGPKIGSSLVQTFAQILGRPLPSAQSIAISSSNLKCSEDSLFSLEGDEGFANDESRRAKWDGQHNFTMGQRAPKRQRTDAHNMTQVIVEVPWKGGHITTMDQATKSTNTGFVTAGSHMTVLAEQSVNRNMDMKEQEDAVKMSSISSKRTSKRPEGQTSLHGFLGKRPPQTREDATSSKRQQPYAPVVPQNFAFQRTANTLLRVEIPSFDKSSLSIAPSLANHRIGPSSILPRPKAKDIDTVPNNNEYVFLSSSPPRPTRSKLEHEMSSPPTAKPTDLTENPSILPHIRPPKVVLKRCASDIAQNLLKDRVTDQGVVESKESSIKRAQSDRSNVAASAKPKRPPVSSLLPPDLPLGSSARTMHKQCMPVTTLKPMPVPDVRQIEKMQVPETRPATTFHTTSMSMLAANTGKRTLGVRRSMTAWSSKGQSFKPPTMSRPAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDJ0</accession>
    <name>A0A3D8RDJ0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Short chain dehydrogenase protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_08153</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDJ0"/>
    <dbReference type="OrthoDB" id="5399006at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE/REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43431:SF7">
        <property type="entry name" value="OXIDOREDUCTASE, SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G14000)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW72119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="248" mass="26292" checksum="CC2481E064EF023D" modified="2019-01-16" version="1">MAAANSFFSVVAGVGAGTGRSVALKFAKTYPVVLLARNPANYESIVKEIKASGGHAIGISTDVSSPQSVSSAFQEIQKELKGKKLAAAVFNVGGKFVRKPFLELSLEDYEAGYDSNGRGFFLFAQAVLPLLLESVESSPHPPSLIITGATASISGRATSASFASGKFALRATGQSLAREFGPKGVHVAHAIIDGVIDIPRTKEYAVNNGAPDGKISADAIADAYWYLHTQPRSHFTQELDVRPYVEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDT5</accession>
    <name>A0A3D8RDT5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_08261</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDT5"/>
    <dbReference type="OrthoDB" id="25921at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF1">
        <property type="entry name" value="PYRIMIDINE PATHWAY REGULATORY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="21"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW72227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="303" mass="34015" checksum="AEACDB15385DB258" modified="2019-01-16" version="1">MDSSLPFLNPQLPCAQELLPSEAFILQMVYSIACQCVPDRGNQLLSLSDACYARALKNIDSATANLTVETLQAITLLALRSLFDPQNGNFGQLVAFAARLAIDIGGQDIPAWGENMRNIHTSIYCMERQFATALDRPPFLPEPTRSINFDISQPSEYLCSLFRIQTKFRGGKEVEAGKFFEMIDIADLEQKVKLDQRISPNILCTVYETQLLLNPTSSAAATMLASYHHPRFIQTFLTAQWIYRAALIVLQPNHNETPSEFDRMQAYGQSLVLLDRASIRWKGSVALSESLRLVGQRIQSRNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIL8</accession>
    <name>A0A3D8RIL8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PCI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_07176</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIL8"/>
    <dbReference type="OrthoDB" id="1713558at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013586">
        <property type="entry name" value="PSMD3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057985">
        <property type="entry name" value="TPR_PSMD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08375">
        <property type="entry name" value="Rpn3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25573">
        <property type="entry name" value="TPR_PSMD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="424"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="38"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="648"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="38"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="648"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="663"/>
            <end position="678"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW73734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="678" mass="75255" checksum="688A4A46077FA847" modified="2019-01-16" version="1">MPFRATRLPYRSVKLQARAVWTWIIDHLKRALRINNSQQTLHHEPTPSTKDTPISSISDLPATQNGCQPLSALTRSPQPEVQFTSRQGASSPGHDDDMPSKTPHTNGKEPVENGINGTKDVEMKDDAQSTLKAGKGKKVKEGEEEMTVVVPPSKGSKLSAPPPKDTDGDLTMDGSANAEGDDLAVKIDPVAKAVADIKGNFPLLEKAVALFDARFSLRALRSISSIRKRLTPDILAQVITETYPSTNPAAQSLLVAIGRENASFTKAGSEMEIDGEKVTKAGKKEPKEIIPEIDIFLGILVQIYYLDNKIVQKGAVFSAHLAERIHALNRRTLDSLSARVYFYFSLFAEQTAPLPPSPASPVIAIRPALLSALRTAVLRKDIDTQSTVIVLLLRNYLSTSHITQADLLISHTKFPENASNNQVARYLYYLGRIRAIQLRYTEAHEHLTAATRKAPSSPSAAGFSQTATKLLLVVELLMGDIPDRATFRLPSLERPLAPYLLLVQAVRVGNLEEFETVIKQHSETFRRDGTYTLILRLRQNVIKTGIRMMSLSYSRISLRDICIRLHLGSEESAEYIVAKAIRDGVIEASLDREKGFMKSKEIGDIYATREPGEAFHDRIRACLSLHDESVKAMRFPMNQHRLELKNAQEAREREREMAKEIQDGDLDEDDLGGEFEGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RK17</accession>
    <name>A0A3D8RK17_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_07623</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RK17"/>
    <dbReference type="OrthoDB" id="5429770at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053175">
        <property type="entry name" value="DHMBA_Reg_Transcription_Factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791:SF5">
        <property type="entry name" value="TRANSCRIPTION FACTOR DBAG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38791">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW74181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="463" mass="53045" checksum="B6EAE10371E3656A" modified="2019-01-16" version="1">MFQHRDIQDFERFADQDSREICSRGFSAVSSLPHVPLIGLPREIVQPINDRATDFFLSAHTFRDSGLIRGYYEYLPEFRNDPKTDITLSTTLNAVALTAYAYAFQYPDLLHEARRLFVSALHLVNNALSSSQEAIKDSTLISIMLFGTFSILTCRSQQSLSDCALHSGGTTTIIKLRGYRQWKTRSQLQLQQQLCSTILQKCIYKSVRVPREVIELRRYAETYLDTNDPAWKLSNAIVKLAVFRADMKELLLCDHYSIVDAATKLDAEFTSLEEEMLVRWHFETVLTKEQSELVFGTYYHAYPDFWEASIWNSLRTCRLLLHEEIANQLKEVLTLFPQPPIPNAAVNYQLSVTTIQQLTLDICATVPQYSSQLLMHLRSLLTAKEYELPESLHFPNTFATDEIPSTAGVYFLFWPLLRAGQLTDSDVQRNWVIRQSRLIGRMTGIQQAFTLANVLESGEELTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RP20</accession>
    <name>A0A3D8RP20_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_06576</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RP20"/>
    <dbReference type="OrthoDB" id="5303703at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="319"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="651"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1114"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="651"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="672"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="712"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="726"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1135"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1148"/>
            <end position="1162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW75755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1162" mass="129673" checksum="E9E1D577FB9E1EA6" modified="2019-01-16" version="1">MDSHKQLSPFPSQLTNSPRQDSGSQRHRICFPSTPGEQQLFHKAIEDHTIPASKLVGTSNNQGAAQQGNLPIGLPFPVSSLNETDNIPATAAADQVNYAPYQDSNTILPLESLVSVSERQIIHEQPVEQMQDAELQHSISCQPQRQDALTLGSTILETPRLVPGEFDHHRQSSELTMDNVMEKAIPAPVQEFQALSASQQSPSTKENIISTDVQETVTDPSISGNPPLPSVMAVREPQVPQDGPVILVQNAQQPPSISTFNEQDIPTNRSEYFLNHNQNVHKDQYSHETTNFDTSPEDPGHNSSGITARASSMQLKEDLGLGTNDEPQDKRKGNASGQISNEWAVDPSDDIQEEANHDLPTTQHIDLSDKDMLDLEDKEDEYDRKEPTAQRSLEEEFFSSAAGKNALPGHKSNIRDLGIIINNKMRLRQPQHQRGFGTAWQDLDDSGTYDPKIEQKLLRKKARNVRRELDEKSTGGNHDRHETDSGSMMTFKLTGGKGLDYLRSITPGPGIGSSLMEVENLADESIVGPRARQPQRSYKIGRAEKSILSNLTPEAPQRQGCKSCVELNDDNCSLIHDGTCYPCNSCRDTGEPCILIIQPEYKRICECCKRKKILCSYRLDHGKNARSCEQCLEDGEECIAGPLRRSFVPKIEKETVGQRRPRQESYQAQLKRQTKTRALKSRIKRQRRRKSTSPFGSYQRRRHISIANNHQNGKKPRKMYRKTPKRSSFSSEEYPRRSSSPQLSGMTADGRPTRNIKTSFCYPLTFNALPKADSKLAPPCDFCDNALFGMCGYGEVEVELADHEVSSRDRVGEMITKTITEEISGGHYENGKDPTNMCIACTMARVRIISCLSHQMVPIRGLDPKTFDYDALEDDLQSQAECSSLLDNHSGNPTFSEVIAEAKAKQAAKRVHIDTHWCFICPSPAFFICSTSEDGTHDSLEGCRLTLCEICNDLLHKLQNSPPAALLTATMATNHRPTTIDQMVQIASAGNMGEWKTGLRADVKFLTTEGELVTFLAQECDEEDERVRKEQIRSSPIMNEDVFVPQDRKETARQQAGISERVTGTKPVIRKRDPHATMVFNGAPTEYNTIDLTKGDDNNIVDLTRYGSVQQTSLSVQEKGKEKATTGDNIQTQVRADETIDLTHDFESEFESESESDSSDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPM6</accession>
    <name>A0A3D8RPM6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Glutathione S-transferase pi-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_06834</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPM6"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03192">
        <property type="entry name" value="GST_C_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03039">
        <property type="entry name" value="GST_N_Sigma_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF150">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02798">
        <property type="entry name" value="GST_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="21"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="2">
        <location>
            <begin position="108"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW76013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="232" mass="26163" checksum="D5C44D520D38A8A2" modified="2019-01-16" version="1">MPTTKVFGTESATNKAIGGIPTIHYFDFLSRGRGQVVRLMLIDAGAAYKDVRYSFDEYPELKQHGVIAKMNPTGNVPIVEMPDGKILTQSYSILRHWSRLFSAYDGKTEEEMYFADVVCDIVIDWRTLFLAAFFSANKAEDYPKHKSGKRKHFLDALERHLNSSDLSCRGPFVIGKEITYADLVLFQILHDEELTRDGKKGLQSYPRLAQLASAVEGRPNVKAFLESDAYLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RQC5</accession>
    <name>A0A3D8RQC5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_06967</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RQC5"/>
    <dbReference type="OrthoDB" id="3563480at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW76146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="154" mass="15931" checksum="590C6E99FFC1F8D1" modified="2019-01-16" version="1">MSPQGEEPPDPTTKDKIIAKITERVKSAQEAQDAATKARQRVDETSDPDEKQAALEEAVKYEKKAASEMKAVQRLQSGVWQGGAGGAGIGAGVGMGLGTVVGTLVGGVASIPTTSIGLLAGMGTGAIHGPWVKLGMGDKNEDEEIVTEERDSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVZ2</accession>
    <name>A0A3D8RVZ2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoside hydrolase family 93 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_06091</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVZ2"/>
    <dbReference type="OrthoDB" id="2130735at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15482">
        <property type="entry name" value="Sialidase_non-viral"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38792">
        <property type="entry name" value="BNR/ASP-BOX REPEAT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G06430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38792:SF3">
        <property type="entry name" value="BNR_ASP-BOX REPEAT DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_7G06430)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017805182" evidence="1">
        <location>
            <begin position="19"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW78239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="389" mass="42649" checksum="56E0CD820F18F153" modified="2019-01-16" version="1">MWFPTLFCVSLLSVAVSAVPHKPGVSSLKPFSTFSNVTIFTPPANYTDPQTLYARTVELENGVLLATWENYSPEPPLVYFPIYKSTDGGETWKMISKITDQVNGWGLRYQPFLYELPAKVGNFPAGTVLAAGNSIPTDLSLTQIDIYASRDKGYTWEFVSKVADGGAAIPNNGIPAIWEPFLLYYKGEIICYYSDQRNPLYGQNLVHTTSADLVSWAPIVPDVEYSTYTARPGMTTVTHLPNGRYIMTYEYGGGPDWGNVTDYEFPVYYRISDSPLNFNESIGYPVVANGIHPTSSPYVTWSPVGGPHGTILVSSGSLTQIFLNTELGAVDAWKVADTPASVSYTRSLRVFKDHPNHVLIAGGGKLPPSTTNKVTVSVIDLKQTLAQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWH9</accession>
    <name>A0A3D8RWH9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_06188</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWH9"/>
    <dbReference type="OrthoDB" id="4850648at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00085">
        <property type="entry name" value="HNHc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003615">
        <property type="entry name" value="HNH_nuc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37827:SF1">
        <property type="entry name" value="HNH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37827">
        <property type="entry name" value="TUDOR DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW78336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="255" mass="29401" checksum="63BAAB49EBAFF578" modified="2019-01-16" version="1">MVPDEELSNYQLFRDCLSTPLIEKSVGDEPKKRKARKYGRKTAIKPVSTQVAGEVNDADELAEFIDYIATEVFSVLPSELRRLSYSTWLNTTQLQNDYSLPLDLDATDDILNVLSPSIIDSFQTYSLLPPNRTPVEFFTPILNTYLTVLTTAPPPPSMTKNQASECEICERSWIPLTYHHLIPREMHTKVLKRGWHTQDMLENVAWICRACHSFVHRVASNEELAKDLYTVDLLRDREDVQKFALWVGKVRWKAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2G9</accession>
    <name>A0A3D8S2G9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_05177</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2G9"/>
    <dbReference type="OrthoDB" id="5394411at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024624">
        <property type="entry name" value="Pyridox_Oxase_Alr4036_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243">
        <property type="entry name" value="AGL049CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28243:SF1">
        <property type="entry name" value="PYRIDOXAMINE 5'-PHOSPHATE OXIDASE ALR4036 FAMILY FMN-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12766">
        <property type="entry name" value="Pyridox_oxase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyridoxamine 5'-phosphate oxidase Alr4036 family FMN-binding" evidence="2">
        <location>
            <begin position="14"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW80479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="291" mass="32310" checksum="E41AA289FAC9F3E8" modified="2019-01-16" version="1">MSTASTTPSSIGPAPWRPIFLTHLSKMDSPEFVFTSLHPAQDPNSPVPYVPRARTCILRGLWAELPENKHNKAPRNEMVYESDLLTVTTDVRMAKVPEIFASGQGHGDISQSQGSGGGGPVEAVFWAKEAMTQWRFRGEAYVVGPDIEGEGDESSGVRTVKSKIGARMRVVQEKGKEGWSWATELTAHFGNLSPGMRGSFKNPEPGSPVSKVPEDSRLSLGQQVNDLHDEICRKNFRVVIIRPDEVEQVDLSVPDKARRWKFTYIGPEAQSRENGDGEEILGEWKKEELWP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2T9</accession>
    <name>A0A3D8S2T9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arginase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_05274</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2T9"/>
    <dbReference type="OrthoDB" id="5232919at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09998">
        <property type="entry name" value="HDAC_Hos3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000011">
        <property type="entry name" value="Histone deacetylase HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053244">
        <property type="entry name" value="HDAC_HD_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47558">
        <property type="entry name" value="HISTONE DEACETYLASE HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47558:SF1">
        <property type="entry name" value="HISTONE DEACETYLASE HOS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="2">
        <location>
            <begin position="262"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="671"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="755"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1125"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="677"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="700"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="835"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="872"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="894"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="923"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="938"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="955"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1023"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1039"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1091"/>
            <end position="1105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW80576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1158" mass="124393" checksum="B7DB1252F06D93AC" modified="2019-01-16" version="1">MSSPSNGTPIRDNKSPPEANSPSQSTVNKGSNVANQIKRLSLNSTSLSPSPQPNPAARAIAQRSLSTSSPNAARSPRSAIHRSPSSMSMDARSSTPTLLRKASMNSIHGVSVVTPPRSSPSRSASLSQAANGRRMSRSPLSSKDEAPPPPRHTAASIAKKHFRSELDIHQDVEDERTAETIVILHDSCYGHRFSRPRTSRAALGTIVERPERIQASVLGVSVAYVRLGDRHSEGQYPLHPSRDATSIPTIPFSIRKTTRKLALTSPAVTNVHGTKWMSELKIMCDSAEAKLAMNGKELARPDLPRSPDEEAPAKFHEGDLYLCSESLDAMEGALGAVCEGVDAVFEGSANGKGPHRTFIAIRPPGHHCSASYPSGFCWLNNVHVGIAHAALTHGLTHAAIIDFDLHHGDGSQAIAWGHNSRARNLPKNAAPWKKTSIGYFSLHDINSYPCEMGDEEKVKNASLCIENAHGQNVWNVHLQPWKSEGEFWELYESKYSVLLEKTRNYLRTQTERLRASPNLPKPKSAIFLSAGFDASEWESSGMQRHKVNVPTEFYARLTRDVVELAAEEGSAAEGRVISVLEGGYSDRALCTGVLSHISGLAGGKTVAVKKEEEHNGLGYEMGQKIGLFDNPQRSPTNLVSAGIPSYDPMWWSLPKLEQLDAVMSNTQTVYEPRPTRETTPPTYSSPTQSSMAKVVSSPRLNRSLSNMSAMSSSSPRPASVARPLSPPPPEVHWTVAAHELSKLLIPSERQINSCRPEDLSAEATRARRDRQSILTPPVAEVSSAPSTASTRMALRERKPAKPVFDAMEDESRKAKAPRRKTVAGAAVLAAEKTVSRSSTPKPDLLNNTQSIQQPNRRLSTASTTASVFSEAPSSRPSGSSRIPSGTTTLPYRPGSSQSIRPDSSMSSRGPSLAVKKTRAPAPSRREGPKPVRVRQESSIDGTSGSSSAQVPLPESSSQSSHASDMDSLTSGMKRIKINLTTKSQREAKDGSKTSIKAPKPPRSTKPKQSESSEILPPEPLPSQVLSSIPSYVQEASETPLPPSSPVVPAPITPNVSTTEPQSPVDVFIPYQPDGPPASTTAPTPESLRWLPPNTATPGATPGATPIKKNELPVFTATSAIPFGVNPHHARAGAENGASATGTSPHGLELEVPETPPQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3K5</accession>
    <name>A0A3D8S3K5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phytanoyl-CoA dioxygenase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_05352</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3K5"/>
    <dbReference type="OrthoDB" id="445007at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008775">
        <property type="entry name" value="Phytyl_CoA_dOase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05721">
        <property type="entry name" value="PhyH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW80654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="34616" checksum="28B031EB7B8054EF" modified="2019-01-16" version="1">MAPIIKPTLRRLPVDAPLEDFIDAITKDGGCVCTNYVTPEEVAQANAEVKPWLDKDKPWKGKLFPPETRRCNRLLWRSKTCREKFFMHPLYQALARHFLSSTDPTWYDEECFWYTSRPLLSAALGIDVRPGAEGQRLHRDDKMYHTRHTDATSTGWTAGRDDGFGVFVPGINTTAENGATRMIPGSHLWGDDRGPKKEEAIYAEMVVGEAAFMFASQYHAGSTNHSRDQNRMLYVLFMCKGTLRQEFATMVEYPPEVAKTFSKELQALLGYRISSPNCGMVDMRDPAFLLDDNYDPEAAGEDVDVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S9L4</accession>
    <name>A0A3D8S9L4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_04454</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW82963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3248909at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF3">
        <property type="entry name" value="SPRAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="651"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="773"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="820"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="887"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1433"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW82963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1565" mass="171260" checksum="40BA5FAA06C725C1" modified="2019-01-16" version="1">MTSDPVSPIDDEEEEALPHDQSQRLFPRQPVASANRVTLSTSSVTHQRTSSFGTLADTASDISRLSTQLSQDIDESWRPDFTVSKLETAYHGANVPESDIAEQASAKNKLRLQEDPLISVQERDLSQEGSSVHSSRECNWLPQGLRWPFLLFLFTVTLGLGLLVLGLMIHSQQNQGLGDEKNKPIFLFGWRFTPTLVAVIYTLLVITMISDIRRTEVYARLSRPNGAPAAITLFYKSRIFWFDPVDALDKKRNNGLRSWALFWASIVNILGLLVISPFSAALLSPADIFLVQDNSPFLEISTAAAQPIQASIDDSILFRSISSLILNTTTSAWLSNDYAVLPFWPADMSSVPLGAILSTAEQEWKANTTVYQTEIDCSTMTLSGIGNFTLNNTVTADNTTSYLVSNLTSYILSSEDGCSLGVAAYPSDFATDNLFALGAAWWTGGNYSYPPLFGSAEMSNFGEMYSSTSTVINSTEQCGNRSVILLSPPWSKYGDTSFQPRGHVCTSSYYSGNVLVSVSNTGSSSSVAFDTNHFDSVKARVNPDAMNTSSFEAAFLSYNWTGKFQFPDVTGIPYMKQSSEVGGPLVPLGAQYGRNITTMLAATDFLDQARQVKQRFLGESMQTALNNIGIGQAESILGTTSISQRRIVVNLGSAIILTALLIISALLIIVVAWLTRLSKRPLNLVQNPTSTVAIASMIVPETATQRLFDGLDRSSENVMREQLDGYVFNLRNGVLYAYDLKMPNQRSQARSLMSSGKGKESDWRPQLLRGWQLIAFLTLLLGIVAALASIYAKYRNTGLYQQFLVSSVNVNIDNTSIQALAPYSILPTFVAVMVKLWWGSVDETFRRLQPYISLAKNPTSNAKGTTLSYISSPLVWAAVKAGKHRHWLLAGVATGALLGEVFTVGMSALWDTNPGVRTFNTILSRDFELRNVPIIFTVNNPSVHGYSVSATTANSKSTLTSMYGNLLTTWLYGAAVEGSFNATPPSWTKDDWAFVPVNLTSADTSASNTTFTSDISNLGPSNNVTVQTPALRGRLECIPLSFSNTSAWLNTLDFTNSSAWNDSKIPADLKTGYELKAGLALNESYAGTYSGYYYFDDDSPYTSIFAVDYRMTCCGNETDGEVGQAAVGYWSPAGIEEPEVSRSVIVKWLVGHPFASQFNDSTPLIDRNSDGYGGHMHWVWKDIPKVMAYNCTPIFETANASVTVDLASGAVQDYQLLDTPVPDENAWAFNYVRHNVSSELNYTDDTWAGAGYDLNGVFVHNITVSYGYLFRNALLGAANSADTGLPPLDVIETSENLDDRTFNFRMPGLNVDFMSYTSLALNNNNMTALLDPDTLYKTSSEVFSLFFKHFVMSTVDTSIGGIYINGSWALQPRGAVIPSDLGYTEDTILLTNGTTLPINTYLQDTSVGVPQDTQSTAAAIRSTRVEQLDLSPAAFFLCLAILAFLVLTLVFILGWHRHYLRLLPRDVDTIGSVLGFVYGSKRFLNLIATNGGNMKSGAVGARVRLGEFVDQDDGKVRYGVEVVDMIPKQEGPARSPEVVEEKSAGGFLERLRGKSVVYKAVDGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SB19</accession>
    <name>A0A3D8SB19_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Chalcone isomerase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_04795</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SB19"/>
    <dbReference type="OrthoDB" id="18193at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016872">
        <property type="term" value="F:intramolecular lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016087">
        <property type="entry name" value="Chalcone_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016088">
        <property type="entry name" value="Chalcone_isomerase_3-sand"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036298">
        <property type="entry name" value="Chalcone_isomerase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47284">
        <property type="entry name" value="FATTY-ACID-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47284:SF3">
        <property type="entry name" value="FATTY-ACID-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16035">
        <property type="entry name" value="Chalcone_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54626">
        <property type="entry name" value="Chalcone isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Chalcone isomerase" evidence="3">
        <location>
            <begin position="170"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW83304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="391" mass="43456" checksum="4A5CAC19A4056B00" modified="2019-01-16" version="1">MSFRTPTVRALRSAPRCISQPQLSSSSRCRHLTTSRRTLSPGHSFSEGGKEPLDAVTLHRLEAARRAYYKRRSYYAGVGFVLGLVGIYVTATWAPLPGKTEKMDSGRQNDPLVVLGKERKVVIQKLGEEPEEIPDVVETGTSTVPTFPRVVEFFDDESGVIRQDDPGMVEYQLMGLGIRTVSFLGVQVYVVGMYIATEDIAVLQKSLIRKIDPTATTLVAGEKEKLRDLLLDPVKGEEVWSQILKESGVRTLVRIVPTRNTDFHHLRDAWVRSITARAQRNKEEFGDEAFGAAVSNFKTLFNRGSVPKQKELLLLRDAKGKLAVWYDDGKSGAQRVGSVDDERISRGLWLNYLGGKTVASEPARQSIISGIMEFVERPIGTVATQVHEVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SBE6</accession>
    <name>A0A3D8SBE6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mitochondrial thiamine pyrophosphate carrier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_04569</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SBE6"/>
    <dbReference type="OrthoDB" id="18574at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090422">
        <property type="term" value="F:thiamine pyrophosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000011">
        <property type="entry name" value="Mitochondrial thiamine pyrophosphate carrier 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24089">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5 13" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="97"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="12">
        <location>
            <begin position="190"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW83078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="296" mass="32799" checksum="757E72721C160747" modified="2019-01-16" version="1">MRFVIAPLDVVKIRLQLQTHSLSDPLSQDPTKLQGSPIYKGTLPTIKRIFQEEGITGLWKGNVPAELMYVSYSAIQFTTYRTVSMGLQKAFEDHRLPAAAESFIAGATAGAVATTATYPLDLLRTRFAAQGTEKVYKSLRASIREIAVNEGPRGFFQGLGAGVGQIIPYMGMFFATYETLRLQIGNLELPFGSGDATAGVIASVIAKTGVFPFDLVRKRLQVQGPTRQRYVHRNIPEYKGVFKTMQSIIKNEGKRGLYRGLTVSLFKAAPASAVTMWTYERALRFLMSMEEEKLKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SGC6</accession>
    <name>A0A3D8SGC6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SGC6"/>
    <dbReference type="OrthoDB" id="3758478at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050977">
        <property type="entry name" value="Fungal_Meroterpenoid_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037401">
        <property type="entry name" value="SnoaL-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39598:SF1">
        <property type="entry name" value="AUSTINOID BIOSYNTHESIS CLUSTERS PROTEIN F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39598">
        <property type="entry name" value="AUSTINOL SYNTHESIS PROTEIN F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12680">
        <property type="entry name" value="SnoaL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SnoaL-like" evidence="1">
        <location>
            <begin position="13"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW85356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="145" mass="16700" checksum="34548AC790DD07D7" modified="2019-01-16" version="1">MSLRDQMLQTAYAYTAVHNEQTFDTLLALCSPDCVHRIGPMSIKNPDRNNDEYIRFNTEVCKRMHTYHAEIMDAVVDETSRKVVLYIHSKGTAPAGEYENEYVITLTMTDDGKKVAHQYDFMDSQTMLNWIAKVGKPARDNWGME</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SGT1</accession>
    <name>A0A3D8SGT1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DUF1752-domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_03841</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SGT1"/>
    <dbReference type="OrthoDB" id="5054775at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031930">
        <property type="term" value="P:mitochondria-nucleus signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006808">
        <property type="term" value="P:regulation of nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021711">
        <property type="entry name" value="DUF3295"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053043">
        <property type="entry name" value="Ras-cAMP_regulatory"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28014:SF1">
        <property type="entry name" value="NEGATIVE REGULATOR OF RAS-CAMP PATHWAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11702">
        <property type="entry name" value="DUF3295"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="2">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3295" evidence="3">
        <location>
            <begin position="88"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3295" evidence="3">
        <location>
            <begin position="304"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="447"/>
            <end position="521"/>
        </location>
    </feature>
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        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="336"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="402"/>
            <end position="411"/>
        </location>
    </feature>
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        <location>
            <begin position="447"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="465"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW85516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="603" mass="66373" checksum="82298517843DBDF4" modified="2019-01-16" version="1">MPSRLDAPVLSVDVGVIHKVDTRNVENLFSMWTVFSRCSGSLDEGRRLENLSWRLWTRETFCCEPNGETNATTPAVSIAKRSSEGQYSQDLPDLSASLDSIADEDVLEFDSNTSSSCTSPLEISRPKIRRQDSLNSRSRGRERHITPDDLEKMVIAIKEKKDLEPLAMSTHSYLAPIPQRTALPTPQPAPQPETITVPAIVESKTESLDSTSDQSSKSAVSDSISCNSERSTTSVVRGFSPSHVSSSYRSIPLLSAPSSIPSADIASATAVSKAAPSKKPAMFALGGSSGDDSFSEQHNSMDSIAPPPQQKKKAIFQFGGSSNEDDSSLSERKQQRSALSSSLKPQGPKKQTSFQEEVATRTIHEDQVFDDDVFETDDEDDIDESAIDDDDDSSDWEDSVEDSGKSSIDDKSFFQRVDSRPNLTSRRSLITTMLHQNDRATALMNAASRSTPALQRSRTSSPNGPSLAASPDSDDASPLMMKRNQKPNGLKPISEIPRSSAQPIIKTTTNTTPHQMALSPRTTRRNMLATELTVSLRQHLLWERQQKSQTANAVLKRRHTAHDVANLKQYPEKVHMQDSEKEPAGSWNQYFSQGLGEYHSKGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SH37</accession>
    <name>A0A3D8SH37_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03965</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SH37"/>
    <dbReference type="OrthoDB" id="2149705at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="782"/>
            <end position="821"/>
        </location>
    </feature>
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        <location>
            <begin position="875"/>
            <end position="906"/>
        </location>
    </feature>
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        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
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            <begin position="91"/>
            <end position="101"/>
        </location>
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            <begin position="219"/>
            <end position="241"/>
        </location>
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            <begin position="287"/>
            <end position="297"/>
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            <begin position="298"/>
            <end position="309"/>
        </location>
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        <location>
            <begin position="360"/>
            <end position="372"/>
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    </feature>
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        <location>
            <begin position="782"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="890"/>
            <end position="906"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW85640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="906" mass="101189" checksum="D8E92212599C5D8F" modified="2019-01-16" version="1">MPLRAKATPTPSAPADRIYKTPIPKEQKKFPERRKRVTYGKSTGPRIPKPDVQTTLTQMYWVDDTEEGQGTEVLDYVEEEEAKRKQKRRRTMGDEHNEIRAVRNRRRAEAAGPASSSIFHTQTLTQWDRSFSAADEEESDMFKEDLEAALEATSPTAIHNEQEGIPKRGVQSQRSIQAGPSKYRGDIYAPKTPKSGRTFEIPSTQSPASPDDADHPFEQPQSPLSNKTTKVSVKTGRNGNSVKGKVKGKPERSIKFSGLGKPQAKRHVSPPKCPTPSHTQRRALLEKSTNFSSMPNKSTEKAPKLKIEDTFETDLETQLSRIPSSPPKLSSPMRSNRFQTADAYIDGSTNNNYGPAAQLPKSTPAAQPSTPRTIFKTEISDSEDDESDLEMESELEETQIEDNYDEAVAPEQFSGVRLVRHDKISNNLLDDPPSTVLASGSNSDIHDEADKLAQSQIKEEVLESQEDMDVSLKVEGIPEVEAKIPIQQPPEKCYDDFGMATQINLHNVDSSLLLSSEEPVPQSEMEDPTLQTQRTTQFSRTQGMESQRLSTQHVDAMAPRFYGSDVFISMHSQQVTEIMMRKRDHHFTPHALHPKTSRIWLYETAPVCLLKYMAVISSALCPGELRDERGIGNLEFNSGKSNVSKYAYEILEVYELADPLSLARLRNYEWLDKAPKNELVRPAVIDHLMANLKPPLFTNVQKELAEVSSSSTDTQEIEAQLISESTQFHQSQVQRSSSPIGATEYATELTTTFVPLHDSSPIPSSSPLQLPQMASIRNVTRSSYRNLPSSKPLTRPSQATTVDLTQTQNTPARPESRNSDVEIVFESPVRKYGPSSTPLSHFEGEGNSNVGFDTTVPYSMASSQLLTKSQLLPESLLTESVPPPRFVYDSQDDEDLYDNDDDYDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHD4</accession>
    <name>A0A3D8SHD4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_04038</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHD4"/>
    <dbReference type="OrthoDB" id="7295497at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051061">
        <property type="entry name" value="Zinc_finger_trans_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179:SF19">
        <property type="entry name" value="C2H2 FINGER DOMAIN TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46179">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="561"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="611"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="649"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="209"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="329"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="391"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="431"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="512"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="579"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="11"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="104"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="329"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="431"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="456"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="474"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="514"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="533"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="588"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="617"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW85713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="689" mass="76687" checksum="20317213AA51BBA6" modified="2019-01-16" version="1">MLSAQPPRRPSSYTPIQNHYWPQSSSLSSTTPQSYDNLSNNLFSFGADQNSLISFQPQQSSSNLRIQVQQPELMQSEHNNSWLSNGQLTPKSATTRAHHHRESSLSSLGSAGPASPYNQPTGSNPHIALSTDPVDIYYELHDPSQQYHSNSKPLTPAHTPSQEQFLTSQYSRFNPQSYPDFSNNADFSQLAAMNGDGGSRSQQAMGDAELMPAPDFGHSGRPSVVSVASNDSPSTPPTFNEDRRKNGETISSNIDFWLDEYLQYCVPSDYRSTMPKLDRTMTDIYQDELYNPNFQITSAPPARSGQSTTVSPAQNDIFNQRLRAANSQHLSSMSQTPMNVPSRERSPFRQGSPLAPAANKFGVQNLQNMRLGTASGLREQQKAENDAMALRQQMERQSPARTPPKTISPKDVDLIYHESDEDANMPLFPKQEQQSPQQYHPQVQQSRVQEPEMDDTSSQQSFGSMATSRRESSGAYSTSSQNTTPHASNFNFGAPLMAGNMRTMPQQYPFVPQARSQTSNVSSTENFPSTLTSMESSSSEYAPESSEIQRPARTSADGGTYTCTYHNCTLRFDTPAKLQKHKREGHRQTATLIGGSSESPEDQANSQAGPHKCERINPSTGKPCNTIFSRPYDLTRHEDTIHNARKQKIRCNLCTEEKTFSRADALTRHYRVVHPQEELPGARRRRVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHE2</accession>
    <name>A0A3D8SHE2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_03899</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHE2"/>
    <dbReference type="OrthoDB" id="5316007at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052479">
        <property type="entry name" value="GPI-anchor_Adhesion_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185">
        <property type="entry name" value="SERINE/THREONINE-RICH PROTEIN ADG2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35185:SF1">
        <property type="entry name" value="UPF0619 GPI-ANCHORED MEMBRANE PROTEIN C1322.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017680078" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="3">
        <location>
            <begin position="19"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="4">
        <location>
            <begin position="23"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="128"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW85574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="247" mass="24339" checksum="8AA309F25F893895" modified="2019-01-16" version="1">MPSYRFISLAALIAVAQAITVTSPTKNTLWNSDNANTITWTSVSTDPTTVDIYLVHQASQPQISDLLFSNVDISKGSVDVTGLQLPTGEAYQINFVKPETTAQIYAQSEQFNVTGTAASATSTLAGYTGPTATPSPSSTSSTSSSSSSSAVSSSTSSASGESSGTSTLTSSSGTASTLLTTSTGSSTTSTGTITTTDSATGASTTATGTSTSSSSATSSSATGNAAAAMTGSAKVAAMVLGAVAMFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHE4</accession>
    <name>A0A3D8SHE4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_04048</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHE4"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW85723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="71" mass="6853" checksum="A5E6C55B301C309A" modified="2019-01-16" version="1">MDRKGAHPVGGAVQHPHRGGGAAWLPAADAADYAELVCAHAAVPVAGAGGAHPGAGCFLHGVLGGGAEHDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHN1</accession>
    <name>A0A3D8SHN1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Patatin-like phospholipase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_04107</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Probable lipid hydrolase.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHN1"/>
    <dbReference type="OrthoDB" id="10049244at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006641">
        <property type="term" value="P:triglyceride metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07229">
        <property type="entry name" value="Pat_TGL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF44">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="7">
        <location>
            <begin position="183"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="551"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="559"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW85782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="578" mass="64626" checksum="31ACED742165F61B" modified="2019-01-16" version="1">MAALLTAIWSMLMDVLFFWQRRFISWLTRKRPVEVWFDILRDAQTYEEWEEAAFQLDVLLGNDLWRQNPTSKYYDYRLIHERLQSIIIAREEGDVQQLVNLLRSGLVRNLGNISTPRLFNRAFAGTKLLIEDYITQVAQAIADVAKLPTSPSTDGSTIVPGFSSQIKLDLLHDTRQAFGRSTLVLQGGAIFGLCHLGVVKALFSRGLLPRIITGTATGALIAALVGIHTEEELPRFLHGDSIDLSAFAGKVGPSQNGEKQGGSLSGWLETLSRRIKRFFREGYFLDVTVLEECVRANVGDLTFEEAYNRTKRVLNITVATTGRGGVPNLLNYLTAPNVLIWSAAVASNASSPSLYGRSITLKCKDASGNILPWSAATDTTFRPWTHASYTDRDSPLSRIAELFNVNHFIVSQARPYLIPFLKSDMHGPSPLYTRGGRTSITGGLLRLMTMEIHHRLQQLDSLQLLPSSIRRFLVDEHIPAAAVTLVPELSAGDFVRLLETPTQSSLDYWILRGEKSVWPAVGALKVRCAVESELDRGYQFVRRRKADGLRRRGSAVDNANEKERARERERANSAGSKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHX1</accession>
    <name>A0A3D8SHX1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="10">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BP5796_04218</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="10"/>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHX1"/>
    <dbReference type="OrthoDB" id="3370at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17956">
        <property type="entry name" value="DEADc_DDX51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="238"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="274"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="633"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="562"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="238"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="97"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="578"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="599"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="610"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDW85893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="818" mass="89291" checksum="382B31CA71DB7E34" modified="2019-01-16" version="1">MSSQLYARYVPPSKKKTPAISPEATEIATPIPSAVSPPPPVTRHDASSSYARYIPPSKTKTKSQPVVILSESNEGRESPSAAKRKREDVTPAEQKPKKSRKSSKHKESKLPSPEPMDVDKPDTSSDENSASANPPSNKTNVEDSDTDLEADKKHKKVLEKREKSLRKAEKLAKKAAKKSKDEGEPEEIEAAPEEPAEIHDLVPLPQPEPKPELPAQSATASLPPWLATPIRVSPTATASFSDLGIEEDVEKSLQSKGFKEAFAVQAAVLPLVLPGPKQQPGDILVQAATGSGKTLSYVLPMIQDISKSTTTRLRGLIVMPTRELVAQAQEVCETCAIAYGGSRKRARIGTAVGNHTLKVEQVALMDQEMRYDPQRYKEQQRKLDAKWESSDVETDGEDDMLCDDESIPTLLDHVLEPTLKVDILICTPGRLVDHLKSTPGFSLEYVKWLVVDEADKLLGQSFQQWLETVMGSFKPASRQSPLRKIILSATMTRDIGQLNSLRLQRPKFVMLEGDAGRDGDEADQTSQAHVLPSLLVESTIKIENDGDKPIYLLELLKSKIMAPRKDSSKADSTSSDDTSSEDDSDDDTSSDDDSDDSSSESSASDASDTSSEDDLTSSEDDSSSDEKSTKTSNVPPAKTAEHSPRGVLIFTKSNETAVRLGRLLALMEPAYVTSIGTLTSTTRNSARKAALNAFLAGKLSILVASDLVSRGLDLPNLAHVVNYDIPTSVTSYVHRVGRTARAGKEGFAWTLLGSTEARWFWHEIARSAAIERPSKTKVGRLNMDAKTFSDEVKERYAEALEKLGQEASVTKRRDKSVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SJ35</accession>
    <name>A0A3D8SJ35_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_04123</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SJ35"/>
    <dbReference type="OrthoDB" id="5416384at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052202">
        <property type="entry name" value="Yeast_MetPath_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782:SF8">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47782">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="9">
        <location>
            <begin position="44"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="595"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="23"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="596"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="612"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW85798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="790" mass="89106" checksum="ED7CF2C9AB0769B6" modified="2019-01-16" version="1">MFAADAFRQGLGSDRARNAKSIRARESSHESEDHSPRIAHTLTACCRCRQRKTRCDPNLPRCLPCERAGAVCEYFDTTKNKKISRTYVIRLQDKVRALEAELGHFTEDAVVPPSTEDVIRPGGLVRLDDNDETPRFLGPSSGIAMTRIVMEEAKRYTDSRSIRDLVPEVRDRRTPAQSPDAPSERKTSYPMISAVPAPTLPSRLVTDKLVEVFNQKAQYLLPTLHEPSFASDLQKVYDGDPDPYRNFVLRMVLAISMQKLDTQYAGLADSYYLAAMTHMEDVIRPKDIKTLQCLVLIAQYSLLTPTRTAIYYIVGLATRLCQQLGLTEEKTITSGYSLGLINPLQLEMRRRLSWIVLSLEFGLAQSMGRPNGFATTQDHVDVGFFEPVDDELITAEGVHQGPLSEKKMVAIHFFRMRLLQAEIRRVLYQKKRPEPKDDGHSWYVEMERKLQNWFDASPQSPSWSAPWFKGRLNTMIIFLFRPSPQVPLPSAHAAIRCYDASAFNIKMHQKQMETNMVDITWVFLLSLFMVINTILWTISYPEVRSLHSKEEVEEHVAIAIDTIIKSQERWPGTEAASQLYSKLAKACLRSYDASESSQPTSSLSANSPSSFADANSPSVSENSSATTGSIAHSAKPLAMPPQFGYVFDQMPEPISNFDYSLPPPQPSFRSNSIFMNPASLQSARRFSYFPPDFTQAPGLPDAWEPVSSSSQPQPMSSQPMIESTYFTQPTPFSFAPRMFGEQVFKTGNSRQGSLSQQQQFELMQSLEADGPTEIDNFMNINAQYENSMNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMA6</accession>
    <name>A0A3D8SMA6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_03100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SMA6"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW87406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="194" mass="22276" checksum="12E4C6F370B143BF" modified="2019-01-16" version="1">MGGLGTVRVLREFEDAGLSTIQITMPIFKGLCAYLSTLIDHGWDISEGDFDLFIFWYPEFIRLKTAGRHLDLLYHEWFYNHRAARGPGPRMILDRLVLNQIKIENPYTFLYTEACITAIAQTSSELPARPVPKACQTQIPPNTEAKALPAVPRMRSLDELCLSALEQPWYSEKGVRDYIGVRDKQELLCWLRQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMF8</accession>
    <name>A0A3D8SMF8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD(P)-binding protein-21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_03199</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SMF8"/>
    <dbReference type="OrthoDB" id="2735536at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="3">
        <location>
            <begin position="6"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW87505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="348" mass="37313" checksum="2416C04CEBE1F506" modified="2019-01-16" version="1">MANELVLITGGTGLIGIKTIVTALRAGYSVRAAVRSQAKFNSILATPTVKALAPGSRLTSVIVPDILVDDAFDEAVKGVQYILHIASPIVKGEGFTPDQWESHLIQPALKGTVGILGSAYKTTGIKRVVITSSEVAIIPWEEFISKEVDTVFDDTYQIPIPKGPYGHLFEAYAASKVHSLIGTKDFVATKKPEWDVINIMPSFVIGDNELVIDPKMITDGTNGAAFAQVLGNDSGWGPTPGSTVHVADVARLHVEALNPQIKGGQDFLAASGGERGTVWNDAIEIVNRNFPKAVAKGVLPNNGTVVTKRIKVDASRTEKVFGFEFLSYEEQVKSVTKQYLELVGEVVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMG0</accession>
    <name>A0A3D8SMG0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03156</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SMG0"/>
    <dbReference type="OrthoDB" id="4776573at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="517"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW87462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="644" mass="71931" checksum="D150ED75D94A39A0" modified="2019-01-16" version="1">MRRWASSEDMSFARRAPGRSPLGSPIWSDFPLLKAGSRSPKLSKSSIDTSAISRPRAASKLSECTTISDPQDATQSTATTSLTEPAYQTPPIEQDVDMVVYAGLEDKAETFAQLIHMTNPEVAGSHRLTSIPSEVRRQIYGYLFPLESRRICLSPRSSTQAVFPDGYFANPWDVLQGVMGGLGSSKALRQDLMTYFWSHFAFHVTVNHFNGPYFCPLSEVGLKIWLKRYLFQVQHLTVEVDLTKFDCSNSVTAPVAQFKTQKIQMSMAKLVAGLISRQGSSEIAELNLMCRRYKGIRPSNHEKSPGHQSDGVPYCPEEYMSVCDDFEMLEGLVRKCRMSGFSRSYTDRLLQTLFRGKMVATERPQVLAWPVIPSPTISLMSTSSGQTWGFLAPIAEDDCDFQQRARVRTLSSSYCSSEMNKRPPSIPSPRTPHLLGPDRNISYRPRQISKPDLPNDTQSRTQQTHDITRFKPPSRSNLTSGNANFGLQPRNDESLPDTEREAYTFSPLARRRRSVDIIKTPDSQGRDKNVKITPRQAASTKLSPKTPNTMNRLNEQDPAYLASLEAMRSSVIPRQASFITQEAVVLLNATNVNSFEGPRLPNSTQTAHAESNVAGGLSGLYQAPIGRERYFNKFVDKLRGTSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMV0</accession>
    <name>A0A3D8SMV0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03363</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SMV0"/>
    <dbReference type="OrthoDB" id="10257049at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08241">
        <property type="entry name" value="QOR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051397">
        <property type="entry name" value="Zn-ADH-like_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677:SF4">
        <property type="entry name" value="QUINONE OXIDOREDUCTASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43677">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="1">
        <location>
            <begin position="12"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW87669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="336" mass="36083" checksum="6FA7154AFCEF8BBE" modified="2019-01-16" version="1">MRGIQIKEYVKGPDELKVVDLPDPVPANDQYLIAIHASATNFFDLLQIAGKYQHQPPLPWVSGSEFAGVILSVPSRSPNPKFKVGDKVFGASQGGYATKVAAKEEALRPVPRGWSFFEAAGLFVTAPTSYGALVTRAGVKEGDYVLVHAAAGGVGLAAVQIAKAFGATVIATAGTKHKLDVAKSFGADHTVNYTDPAWSELVKKLTPKNRGVDIVFDPVGMIDKSTKCIRWNGRLLVIGFAAGSIEKVAMNKVLLKNISIVGLHWGAYTINEPEKIPEVWDGLFKLIDAGKFRGTVFTDQEFVGLESVPAALKSLGSRGTWGKVVVKVPQESRSRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SN56</accession>
    <name>A0A3D8SN56_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_03463</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the putative lipase ROG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="7464126at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="13"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="6">
        <location>
            <begin position="218"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="7">
        <location>
            <begin position="476"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="996"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="1029"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="1062"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="1095"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="1227"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="1296"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="1361"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="1394"/>
            <end position="1426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW87769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1482" mass="163269" checksum="E6BC61AD62E458E4" modified="2019-01-16" version="1">MFATRDVPFETILAVAAVQLFAVAIALICWKFAVQRQPDQTPTTKPSPQSSTFRLSGIPKDFGSKEEIQAWLQCLPGFAGSQNTASSSKEPACRENSNSLDIKISIASENLRYSQAIVTVTSTSSIAIPARIKGPPGHEIEIDDHFQGLTVLYADDTADAGDGIAADIIFVHGLGGHAIHSWRSRTSSEFWIVDFLPQDVKHARIMTYGYDTTLDIGGKQHHGKKSINSLAKSMLEEICTMRYDEATQKRPIIFMGHSLGGLVIKEALVTASKSKGHKPWQRIFQSCQSLVFFGVPNLGMSFEELARMVDGSESEQLVRDLLVDNDHDTRPLLQRLNEEFVECLQHRNDLDILCYYETKLSPRISKEKDQGISHRGTLIVNQASAAYTGLTARSYNILELEGDHRSMVKFAERNRTGYRGLSRRIKQFIDRAIETGRSDFIDFSTKLTTEDQACIQSLAYTEMGYRRQEADGAHPNTCNWILEHENHKRWRYENRGLLWIKGKPGSGKSTLMAFLYGHLQKVPPVERGLSLDYFFHRRGVELQKSINGMLRSFLCQLYIKVPSVRKVIFRPFQEKRLFGEAGAAWQWQPKELRDLFIEAVVVAATSMKMTIFVDALDEAGEEGARDLASFFHHLNDRLDQAQGTAKICISCRHYPIVATIPGLEIWVENYNSYDIALYVRDTLYVMVPREFDSTSTAIKDLESDIVEKSSGVFQWARLVLPIVAEQINDGDSIEEVHALLARVPQGLSEIYEYILKSVIKRRNYDKTLRLMRWVCLAERPLSLTELRYAMVAIDASIHSTARSFEKVVGFADSDERMARQTISLSGGLAEVKYQDNGSTVVQFVHQSVNDYLRSSGLAFLVSLCQDKASVDNSVTMSEDFTDDIIGGSQHWLTQSCVTYVLSAETSLPGRIYIQDRHIVSEKEREVLSGIQEKLPFIVYATGYWLVHAEKAESHGFFQTHLIEAFGSPPGPAFQAWIEFHKFLKHIERWQISSHETGSTLLHAGCSSNLSSVVEALLNRGTDPNQKDDAGNRPLHLAARKGVDKLAQMLIERGAEIRAKNNSHNTALELAAANGAVEIVNRLLNLGVDVNESTGDSGNALYGAAIKGSEPLVRILLRNGADVNAQGGLYGNALQAASLNGHEGTVKLLLDMQADINAQGGLYGNALQVASFNGHEGTVKLLLDMQADINAPGGHFGNALQVASFNGHEGIVKLLLDMQADVNAPGGHFGNALQAASLKGHEGIVKLLLDMQADVNAQGGYCGNALQAASSGGHEETVKLLLDMQADVNAQGGIYGNALQAASFNGHKETVKLLLNRGANMAGSDMQGRNALYLAMRGNSEAIFQILISLKALREWATPDVQGCSSLHFAASGGSTEALASLLDTGCDVNELDTYGWTALHWASRNGSHSACQMLLTAGCDVSKKDSSNRTAFDVAVMCQHGSLLSLLYPQISSEEASNILSTFGRKRHYPQCSCCFNVSTIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SND5</accession>
    <name>A0A3D8SND5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7624 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_03490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SND5"/>
    <dbReference type="OrthoDB" id="5230484at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056041">
        <property type="entry name" value="DUF7624"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24616">
        <property type="entry name" value="DUF7624"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7624" evidence="2">
        <location>
            <begin position="584"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF24616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW87796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="722" mass="79537" checksum="17CCD8980C6CBCE6" modified="2019-01-16" version="1">MALESPLVSAGNHMSAFSPHPDFSMSPHSPAMPNPPRYHPLSPLHSTESSLLNPSSIDGGLSPGGQLTSPSDMVGPSPVTSNGTETTDFDDETMEENHEHTPPHSMAPDGSVQASRLSAIRTSLPEEFRASVDDESVSVIHAPQGYGSFERNNSTITVTAPQSPDRATPIPYKLIDDSLSSDKPAHIKVDRAVPSDKTAQPSPKSPPPISTDVQPVKYGPEHATPRAQTRKEIEALSDNATPYARNSTAVNLQGIPEDQGETEEDDFDVRTVQNSQEEIAALDTALHECWTLCNTLASLSSIHRERIFSYSGTGDAHEIAWKCCWKLCQKLYDSRDDEIDFQVQPTLDLCRDFCQALFDVRQRKNEIDDSVLRVSFELNNHLFNTHDRTLPEAFRERTLDFYITLCHRLMKQRGELAEETDSLLRACWGLAEMLFSLRQNKREGKAADEELLGSAVQACWELCDLFREGWTQVRPDRGTPRPSQTTFGQSSDLLNRSSHTLSNSLDSLPEQQEDLPIKPPQFPETPTTEFEDTPISPEANSPNIPNILVLGTDNSRTGSTRWSSTASNLSGYSQGSNRSTNTVTSTGNTEDINLTRLKTLILKAAMNVGFDRNSSSTATGTGSPPPALQTFVKSLPTGSFGSLPSHANLLRDYRNLVLSDPTFRSKNSLPAPGKKVSAVDVAKSVTWMMRSGQYTFLKDLFRLVFGFKVDEAEKRQSISITV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SNJ4</accession>
    <name>A0A3D8SNJ4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">FAD-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_03546</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the paxM FAD-dependent monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SNJ4"/>
    <dbReference type="OrthoDB" id="9993796at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050493">
        <property type="entry name" value="FAD-dep_Monooxygenase_BioMet"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789:SF314">
        <property type="entry name" value="FAD-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13789">
        <property type="entry name" value="MONOOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="6">
        <location>
            <begin position="5"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW87852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="432" mass="47230" checksum="83CF23FFFE646CBA" modified="2019-01-16" version="1">MADLRIIVVGGGIAGLVAALALRAPRREVIVLEASRMNKELGALISLQPNASKIATSLGLDSILASTGPMEDKAFRVYNPEGQKQMDIPSDFQKYGAQRIIYHRVDLHNALKEACTAPHGYGKPVQIIPSSRVLTADCEKGIVNLESGTTYQGDIIIGADGIHSNLRTSVLGQGVSAPKPTGLSAYRLLLDTADLERSKAFTSVINPREAATIMVVGHDRRIVMGPGRDGSVYGVVAIVPDEHMKEDSDMKSWTSEGDTTKLFESFAEFPEWIKDVLRASNTAPALYQLRDIDPLPNWVRGRTILIGDAAHAMLPTQGQGASQSFEDAEALQAFLRDVNKDTSEAEIKHCLREVYETRHARASLIQAYSRQQAKPGMDPATMKVKLNPVEFLDYNCKYDGAKAWRQKMNKQNVVEGVVSHTTVPLKVVEPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SNK3</accession>
    <name>A0A3D8SNK3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03571</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SNK3"/>
    <dbReference type="OrthoDB" id="3489571at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017709033" evidence="1">
        <location>
            <begin position="19"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW87877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="100" mass="11202" checksum="33128C7939DE98D3" modified="2019-01-16" version="1">MQLSQIAFLATLVVGVMADMHHVAACTGTDYVWGSDINSEATSCACWNYQRRNTGNNWWDKCPDCAYDGTYCNSKFKHIGGDEFYYYCTQKCGAKNSIAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SX73</accession>
    <name>A0A3D8SX73_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_02080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW90915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SX73"/>
    <dbReference type="OrthoDB" id="6730379at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF97">
        <property type="entry name" value="ALLANTOATE TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14700)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="72"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="426"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="458"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="72"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW90915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="525" mass="58591" checksum="3635DD662F7E2416" modified="2019-01-16" version="1">MSANINNNEKYEADAVSMVEDAADIKVAADLKHAINQPHVEIYAEALTKYPNDESIDQAAEAKLKRKLDRRIIPLLGLCYFFYYVDKTTLSYAAIFGLKTDLHLVGTQYSWLSSLFYFGWFVWAIPSNLIMQKCPPGWYLAFNIFMWGVLLMAQAASQKFVTLAALRILSGAFEAIADPAFMLVTSMYYTRAEQPSRIAAWYCFNGIGVAGGGLIGYGVGNIKGSLQSWRYEFIIVGVLCAAWGIALFFLLPNSPVTFWGFNHDEKLIMIARLRKNQTGIEQRHINWGQIKEAYLDYKTWLFTLLGFVGNIPNGGISNFSTLVIKGLGFDTLHTSLLGIPQGAIVVIWIGLGALCNRYMPANSRTIICAMFMLPTIAGALGFLLAPTHAYIGRLICFYMTGSYQASFVLSLSLVTSNTGGQSKKMIVSGMIWFGACIGNIASPFFYRTEQAPNYPLGIGSLLVANFIELALFFIFRYAFLWENKQKERKRAALRASGETDDYSNLNATAFTNMTDKENPNFVYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXX4</accession>
    <name>A0A3D8SXX4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative DUF431 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_02347</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SXX4"/>
    <dbReference type="OrthoDB" id="373498at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18090">
        <property type="entry name" value="Arginine_MT_Sfm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007364">
        <property type="entry name" value="SFM1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35517:SF1">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE SFM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04252">
        <property type="entry name" value="SFM1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW91182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="205" mass="22786" checksum="616B35C4CFCFD196" modified="2019-01-16" version="1">MTSKTYIVEHLDDELGPWSELEYVTIAKESHEAGSKFCLSSVPPALELPAVLTAVPGFAADGRSVETLYAKDKARVCLLDPSATKELSPEDGEIFDVFLFGGILGDDPPRDRTSELRKKGFQGRRLGPMQMTTDTAVRVTRMIVQSKIPLDQISYIDNPELVVNKNESTEMPFRYVKGEDGQPIMPEGMVELIKRDSEKGFAELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYU1</accession>
    <name>A0A3D8SYU1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetyl-CoA hydrolase</fullName>
            <ecNumber evidence="4">3.1.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Acetyl-CoA deacylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_02658</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>acetyl-CoA + H2O = acetate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20289"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="EC" id="3.1.2.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyl-CoA hydrolase/transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.2.1" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYU1"/>
    <dbReference type="OrthoDB" id="10250396at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008775">
        <property type="term" value="F:acetate CoA-transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003986">
        <property type="term" value="F:acetyl-CoA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02183">
        <property type="entry name" value="GH16_fungal_CRH1_transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.750.70:FF:000002">
        <property type="entry name" value="Acetyl-CoA hydrolase Ach1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.10:FF:000003">
        <property type="entry name" value="Acetyl-coA hydrolase Ach1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1080.20:FF:000001">
        <property type="entry name" value="Acetyl-CoA hydrolase Ach1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.750.70">
        <property type="entry name" value="4-hydroxybutyrate coenzyme like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.20">
        <property type="entry name" value="Acetyl-CoA hydrolase/transferase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1080.10">
        <property type="entry name" value="Glutaconate Coenzyme A-transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026888">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038460">
        <property type="entry name" value="AcetylCoA_hyd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046433">
        <property type="entry name" value="ActCoA_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003702">
        <property type="entry name" value="ActCoA_hydro_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000757">
        <property type="entry name" value="Beta-glucanase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43609">
        <property type="entry name" value="ACETYL-COA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43609:SF1">
        <property type="entry name" value="ACETYL-COA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13336">
        <property type="entry name" value="AcetylCoA_hyd_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02550">
        <property type="entry name" value="AcetylCoA_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00722">
        <property type="entry name" value="Glyco_hydro_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51762">
        <property type="entry name" value="GH16_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017603632" description="Acetyl-CoA hydrolase" evidence="10">
        <location>
            <begin position="22"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="domain" description="GH16" evidence="11">
        <location>
            <begin position="23"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="269"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="343"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW91493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1015" mass="111109" checksum="0DA4829D1FEAC950" modified="2019-01-16" version="1">MVSRFIQLATVALTVFQAVKGQTSTSCNPTENSTCPSDAALGKTVTIDFTQGNSSYFTEESGTTVTYGDNGAEFILESDGLAKTVVSTKYIMFGRVNVTMKAAPGTGVISCLVMESDDLDEIDWEWLGGNTTVVESNYFGKGNTTSYNRAVYHAVDDPQDEWHMYTIDWTSARTNWYIDSVLVRTLLYADALDGANYPQTPMNIKLGIWDGGAADESTGTVEWAGGYTDLTNAPFTMYVKNMTIEDYTTDGDTYTYSDESGSYTSIVVSNSTDSSSSTVASASGDTDSSSSSSNSTSSSSSTSSSSSSEASTTSSTSDAMQANFAQGRKLALTLAGLVSQAIPGTSPAPAGSLQVPPRWRWGSRKGQARRAEGAQEASDLVRWRRRPVPASTRPARQVRPTSHTRGSRDVKLQGEPYHHMAWWGGLLESKRKYPPNRLSPPANFFSYPSALHSIALCRPSELSPQLRRDLFGSGQFVCCFRSEGEMASRAGLAASAALKARVRRPSLLNKLAHPEDLISLFPNGSYIGWSGFTGVGYPKKIPTMLADHVESNNLQGKLKYSLFVGASSGAETENRWAALNMIERRSPHQVGKSIAKGINNGDIKFFDKHLSMFPVDLVYGFYTKDRPNKKLDVVIVEATAITEDGGIVPGASVGASPELIQMADKIIVEVNTSMPSFEGLHDITMTQLPPHRKPYLIMSPEDRIGTTSIPVDTEKIVAIVESDYQDQTVPNSAADATSAAIANHLIEFLEHEVKHDRLPKNLLPIQSGIGNIANAVIGGLAESKFEHLKVWTEVLQDTFLDLFDSGRLDFATATSIRFSPDGFKRFYDGWEQYYNKLLLRSQQVSNSPEIIRRLGVIGMNTPVEVDIYAHANSTCVMGSRMLNGLGGSADFLRSAKYSIMHTPSTRPSKSDPLGVSCIVPMCTHVDQTEHDLDVVVTEQGLADVRGLSPKERAKVIIEKTAHPEYRPILEDYFAKAEFECMRRGWGHEPHLLWNSFDMHKAFDQEGSMRKLKTWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZH3</accession>
    <name>A0A3D8SZH3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02859</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZH3"/>
    <dbReference type="OrthoDB" id="3565113at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166:SF1">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38166">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="774"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="885"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="492"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="774"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="824"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="887"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="911"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="943"/>
            <end position="953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1039" mass="115290" checksum="9269B2A1A221A85F" modified="2019-01-16" version="1">MSLNNLQTRPSACEPSEHVIPFNLDLQKSLQHWPIQDLNKRKAHLVSEQTSKRRLLDSGSSLWSRGSTPLSIPESSSQHGEDLEERDGQANDCISKEEPDHDMLEELKYTPRLHTNSEASRSSTGLGLYLCTPALTMSDCSSKRSSSAQFVASPRSAISDDHDFIDREIAITSILSSPDSSLDCPSNVGFQCTFVHLYSSLYISYHLTNPFSMVIDPSVLDLGQEQSVAELKYDPWAHLPFFVEGEVASWQENYIGDCSVHISDTDAAPSDVPHFVICGTDGIPKPVDVIDLTSPPRCDSVNKFRIFKAPFINVEKEELENRDEPPTEMVNDSAIFTSRQDDAYPRLQVSSHNHTGSSPTKVVTLSSASPGIQLRNEESPLEIKMCLKKDSIEDWSLDIPEDIDNQEIGDVQSPSTTILMATAEEDLEERVRAVTGDDHNYGQALLANLKEKLPEILPLFCGEDFCGEDYSPLEFSNYASSVTYGSGYTNRSGSSSAPPSDTKSSAGVSINTSATSSGSSRKHNRADDEENHTGRDQRQPSKKPKASRPGTRGVQDRRRFKCHFYTKCPLSHTKKTCVMSGWPSIHHLRGHYESHHTTIRCNKCFKEFEGPYARTEKNRHQKGCKIEAAPPSLEVIDCDKKDELEESLGFRTWQLHSEPDEVMKAWILKYKPEYVTNNAPTDEAYDSRELAKWYRIWQTLFPDLRTPVPSPFQDTSILPADLKIERLLEIFQSIVDTNIQQDRKPPADQPQQIDYYKECVRKLFKIILPRAPSSENMLSGSATNQRGDTRSISTPANSGTTSAPGIHTPSSSRVSTQRLERSKQTQPVEYLNSSPRDRSSSPVADLSTSPRLPPRNGFLVTSPCSAETKGAVGETPVIVRTVPINRSRGNSASDSSLNMHPHAREVPRGNLSLQIPRTTGSPQVRATSRSPMTNLMPPPQMRQRASVSPSHSHAGNPAQVFQDSAMDFTLTNNLTAFNASMTPSNFNFIGLAVDQGSPVWPNVAVPQPAAVGCQYCMDSGIIYFETHTQTCLMCGDNDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZQ2</accession>
    <name>A0A3D8SZQ2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_02816</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZQ2"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF77">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="314"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="19"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW91651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="514" mass="57119" checksum="D3A0B99C40C76CCC" modified="2019-01-16" version="1">MAILNLNINWRHHKWALFYCLVSTIGALCYGYDTIYYTGIQGMEAFVHDYGQRTSDGTYALSTTFLSVTASLIYVGEFVGALLTAPINDKWGRKAVFLSASICIIIGAIVQLVAHGMYAVFCLGRVLIGLGIGQFTATCLIYIGDIASAEFRGPALMMFQFMQSISQLVVSCIDQGTESLHNANSYRIPMGLLIVLPGIMIILLPFIPESPTWYIYKGHHAKAEKSLRQINRSMPSYDPSADIQNIDDQVAMERQMESQSTWASVFRDPVERRKLIYACGAMLAQQINGIQFWYTYGVVFAQSIGTAQPFTINTITNVVQIVAVGLSVLLGNKMRRRVNLLVCTCGMFISLIVVGGLGTTHRGGPFSQPVGITIVVFSYINIICFNFSIGTLSYTMASEMSVGRNRNKITAAAIGVFFFTVWLMVFISPYLYFTARLGPMLGFVFAGTTLLTLAYVWFCVGETTGRSNTEIDRFFLEHIPVRKWRTHAFAPVNDEPKNMEEDVPVHLEEAAEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZU1</accession>
    <name>A0A3D8SZU1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_01229</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZU1"/>
    <dbReference type="OrthoDB" id="5398233at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF19">
        <property type="entry name" value="MEMBRANE PROTEIN PTH11-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G14080)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="21"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="246"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="311"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="392"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="323"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="408"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW91835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="429" mass="47132" checksum="48D8BDE873347AFC" modified="2019-01-16" version="1">MSSRPTSRPPASIVAPLGAGCLWMLKLTISEFFKRLTIQIWQRSHERMLQFIRHFLAISFVAVVIADLAECQPFTHYWQVTPDPGAKCRQGYAQLITMGVFNVLTDLLLVLFPVPIIIRSQMPVKRKVQLVLLFAGSLIPAGTTLYRIPNIIDKHGSQQYRSLLASIEILFATAVCNALVLGSFVRDRGVKKQRWKFGSLSDSIERTTSRRGTVVRHWGSDEDLIRDIGLGIDVDLREAPIARPAPMASAAGREAMPSKARQSGMGSGWDFPRSDTSGESESILYKIPEGAHSLGDGSSLASPRRVSFFDVGGLLDEEPPRRLSSTRTNDTDLESQASPGGLHQTNSQEYGGNGLSPAPPRRGSAAFLQDVGGLLGPRTRNFARGSGYELQTIHQERSPSPMSQQHSPLERLTREPTNHSLQDVGGLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T099</accession>
    <name>A0A3D8T099_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_01245</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T099"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="136"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="214" mass="24806" checksum="32D5E2702A81152B" modified="2019-01-16" version="1">MKAVFGDDIFPFDSWKEFKIAIDDIEEDYSFKEYTQHMFGGRGIGCKIPLSIQIFCFDKTGESSMTWSSSLALGWIEEDLEWFYERFVDSDFDGARMWYEFPGYYTLKKRSDELSADKTAMGDRHRRFFGNYSTDSNTARTQATLPSSKKNTSITKSEPQSVEEINDEVKSVLPMVTVKDFCTAFSEFVPGMGEMIEERVYSLMQKSMIMDDQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0T8</accession>
    <name>A0A3D8T0T8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Imidazole glycerol phosphate synthase hisHF</fullName>
        </recommendedName>
        <domain>
            <recommendedName>
                <fullName evidence="12">Glutaminase</fullName>
                <ecNumber evidence="12">3.5.1.2</ecNumber>
            </recommendedName>
        </domain>
        <domain>
            <recommendedName>
                <fullName evidence="12">Cyclase</fullName>
            </recommendedName>
        </domain>
    </protein>
    <gene>
        <name evidence="17" type="ORF">BP5796_01579</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17 18">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10 12">IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 12">
            <text>5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine = D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24793"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58278"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58475"/>
            <dbReference type="ChEBI" id="CHEBI:58525"/>
            <dbReference type="EC" id="4.3.2.10"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>L-glutamine + H2O = L-glutamate + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:15889"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="EC" id="3.5.1.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 12">Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 5/9.</text>
    </comment>
    <comment type="similarity">
        <text evidence="15">Belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11 12">In the C-terminal section; belongs to the HisA/HisF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.2" evidence="12"/>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0T8"/>
    <dbReference type="OrthoDB" id="10254903at2759"/>
    <dbReference type="UniPathway" id="UPA00031">
        <property type="reaction ID" value="UER00010"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004359">
        <property type="term" value="F:glutaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000107">
        <property type="term" value="F:imidazoleglycerol-phosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000105">
        <property type="term" value="P:L-histidine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01748">
        <property type="entry name" value="GATase1_IGP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04731">
        <property type="entry name" value="HisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000094">
        <property type="entry name" value="Imidazole glycerol phosphate synthase hisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000039">
        <property type="entry name" value="Imidazole glycerol phosphate synthase hisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00278">
        <property type="entry name" value="HisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006062">
        <property type="entry name" value="His_biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004651">
        <property type="entry name" value="HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050064">
        <property type="entry name" value="IGPS_HisA/HisF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014640">
        <property type="entry name" value="IGPS_HisHF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010139">
        <property type="entry name" value="Imidazole-glycPsynth_HisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011060">
        <property type="entry name" value="RibuloseP-bd_barrel"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00735">
        <property type="entry name" value="hisF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01855">
        <property type="entry name" value="IMP_synth_hisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235:SF2">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE HISHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21235">
        <property type="entry name" value="IMIDAZOLE GLYCEROL PHOSPHATE SYNTHASE SUBUNIT HISF/H IGP SYNTHASE SUBUNIT HISF/H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00977">
        <property type="entry name" value="His_biosynth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036936">
        <property type="entry name" value="IGPS_HisHF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51366">
        <property type="entry name" value="Ribulose-phoshate binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 12 15" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="4 12" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 12 15" id="KW-0368">Histidine biosynthesis</keyword>
    <keyword evidence="3 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 12" id="KW-0456">Lyase</keyword>
    <keyword evidence="7 12" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase" evidence="16">
        <location>
            <begin position="6"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="355"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="393"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="465"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="491"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="PRFAR binding" evidence="14">
        <location>
            <begin position="514"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="81"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="active site" description="For GATase activity" evidence="13">
        <location>
            <position position="190"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="active site" evidence="13">
        <location>
            <position position="395"/>
        </location>
    </feature>
    <feature type="binding site" description="covalent" evidence="14">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>L-glutamine</name>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00055946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00061106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRNR" id="PIRNR036936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR036936-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR036936-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="RDW92185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="545" mass="58913" checksum="1BC22CC3CB3FDBB8" modified="2019-01-16" version="1">MSKVYLLDYVAGNVRSLVNAIEKVGYTVEWVRSPEDVAKADKLILPGVGHFGHCMTQFASAGYLPAIQKHVDSGKPFMGICVGLQALFEGSAENPAVPGLGLIKGRLDRFDDTSKSVPHIGWNSANTADKQVYGLRPSSKYYYVHSYKVPYKKGEYESQGWTVATGKYGDEEFVGAIAKGNILATQFHPEKSGAAGLRVLKAFLDGNYSEALDPKSESRPQTTQEGLTRRVIACLDVRTNDQGDLVVTKGDQYDVREKGEGGNVRNLGKPVEMAKKYYEQGADEITFLNITSFRDCPLADLPMLEILRRTSESVFVPLTIGGGIRDTTDTDGTKVSALEIATMYFKSGADKVSIGSDAVTAAEEYYANGKKLAGSTAIEQISGAYGNQAVVVSVDPKRVYVSKPEDTKHNTIATKYPGSNGETTCWYACTIKGGRETRDMDVVELAQAVEAMGTGEILLNCIDKDGTNSGFDLELIDQVKGAVSIPVIASSGAGNPGHFEEVFSKTKTDAALGAGMFHRGEYTVKQVKDFLGEKGLVVRQFEGEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1G9</accession>
    <name>A0A3D8T1G9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TPR-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_01655</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1G9"/>
    <dbReference type="OrthoDB" id="10050400at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031942">
        <property type="term" value="C:i-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006515">
        <property type="term" value="P:protein quality control for misfolded or incompletely synthesized proteins"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd24145">
        <property type="entry name" value="Mgr3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040201">
        <property type="entry name" value="Mrg3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28142:SF1">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE I-AAA PROTEASE SUPERCOMPLEX SUBUNIT MGR3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW92261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="416" mass="47152" checksum="684FAEA568849BCF" modified="2019-01-16" version="1">MLASRTRGLFRPISSRATQCLRQQQAAPTCQRPWQLQLQNQQRRHKFTGAREPRRSLGQNMKVLWRENPFSVTLALGFIAFGIGSWMYINYIYQSYFIGAFHKYPEPVAKQLRKAIFYTNYQMDPKLALKYYKEALRVAADEGMDPFSDEIIGVKIQVAALMEKIQQYRKAIEVLEIVKHDCLDWVDKRGSIPGNEGDRTRILGKTVGISVKLGELYGNQYVMEKELAEERLVWAVETVLRESQRRQREGIKPGEGEWLSNEENGATMEALANTYEAKDQHYLAAPLYLQAIALSPTTSCHTTILMNNLSISLAQQLPPLEPGQKPLPREVMVSNARSWAEKALAIAAKITPPERTDECDVGCAVATHNLGEFAEMDGNIREARKRYEEAKALAKAIGFEEGVQNSNLALKRLDKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7X0</accession>
    <name>A0A3D8T7X0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Adenosine deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_00412</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>N(6)-methyl-AMP + H2O + H(+) = IMP + methylamine</text>
            <dbReference type="Rhea" id="RHEA:16001"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:59338"/>
            <dbReference type="ChEBI" id="CHEBI:144842"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="7">
            <dbReference type="Rhea" id="RHEA:16002"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7X0"/>
    <dbReference type="OrthoDB" id="272271at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004000">
        <property type="term" value="F:adenosine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006154">
        <property type="term" value="P:adenosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046103">
        <property type="term" value="P:inosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001365">
        <property type="entry name" value="A_deaminase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006330">
        <property type="entry name" value="Ado/ade_deaminase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409">
        <property type="entry name" value="ADENOSINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11409:SF42">
        <property type="entry name" value="ADENOSINE DEAMINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00962">
        <property type="entry name" value="A_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Adenosine deaminase" evidence="8">
        <location>
            <begin position="3"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW94649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="233" mass="25598" checksum="C6ACC1884882170C" modified="2019-01-16" version="1">MPSAGLSKEGYVETVLKCIADSNNAPNSSMTTGLILSIDRRNDVDTAIAVVDLAVQYRDQGVVGIDLCGDPCVGDVSIFEPAFTKAKANNLPITIHFAEAPFSSTEVELRKLLEYQPDRIGHVINVPADIKEEIVKRKLGLELCLSCNVHAKMITGSYGDHHFGWWKDTGCPITLCTDDVGVFGSTVSMEYALIAEHFDLDRKEICELARSGIDTIFASEKVKQKLRETMWSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7Y3</accession>
    <name>A0A3D8T7Y3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_00403</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7Y3"/>
    <dbReference type="OrthoDB" id="10407503at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="156"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="207"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="253"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW94640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="365" mass="38869" checksum="366BC7D2DF06CC45" modified="2019-01-16" version="1">MPNYSQHQSLRSAFLASRSPTQLTDIATASLLPLLCDTYLDAVFYCLQSLLYSGLCAPLQLPSNHHIFLDKAQLAPSRTMETSILSHVANGPGSKPNNALPVSGNQASSRSENQLISHRKKFIVSSSNNQDVEFYQTPLSDAHGSLPDGYQQPNQGSSASSSSSSSGDSGDSGFSSAADGVGAAPAAGGAGTGGDEDGEDKRAMSSSEDDDDDDDDEEEDDDDDEDSDEDLAIEMNLGLGVLEHLSPASGITEANAPEPSSSNSNSGKEKRKPTEGSEEVINVRPLEKKPRFVMPPASSIASRLPGFLDALRVANEELARNPEKFAMGEEIVEERDEEMKEKKVEGDEAEGKGEEGQKTTLIEEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7Z4</accession>
    <name>A0A3D8T7Z4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">YEATS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_00408</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7Z4"/>
    <dbReference type="OrthoDB" id="1741717at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16905">
        <property type="entry name" value="YEATS_Taf14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027353">
        <property type="entry name" value="NET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038336">
        <property type="entry name" value="NET_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23195">
        <property type="entry name" value="YEATS DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17035">
        <property type="entry name" value="BET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YEATS" evidence="4">
        <location>
            <begin position="62"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="198"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW94645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="291" mass="33200" checksum="4C66073199EF0CB9" modified="2019-01-16" version="1">MNRSQSCDGYITPGSEDLPTFTSVTPHPRSSRCRKIVHVSTASPRFYYSPTFNYAQERAFKMVADIKRTVLLVTEQRNIDKPPEMTGYPMKSWNIEVFLLDDAGNEQPASCFVKVVYNLHPSFKNPIQTFAKPPFRCENEGWGEFDMTIDLYTTEKAKHTIHHDLNFAKTKYEAKHLITFKNPSAALVELLRDTGSIPGEGVENGQRKKDVEKKRKRTAGTVDMEKLADGLVKLAEDDLLQVVQMIHDNKSDETYTKNDVDQGEFHVDLYTLPDTLVKMLWDFVVKQQTGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T897</accession>
    <name>A0A3D8T897_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Transmembrane GTPase fzo1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_00533</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T897"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008053">
        <property type="term" value="P:mitochondrial fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051646">
        <property type="term" value="P:mitochondrion localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000638">
        <property type="entry name" value="Transmembrane GTPase Fzo1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027094">
        <property type="entry name" value="Mitofusin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465:SF0">
        <property type="entry name" value="SARCALUMENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465">
        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="4" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="13">
        <location>
            <begin position="277"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="147"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="493"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="169"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="503"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="527"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW94770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="923" mass="100647" checksum="B51DC13554673C36" modified="2019-01-16" version="1">MSQEHQNGKGKGSGHSAGGSNDANGSNAPPVSSRPQYVTVGSGSTTESAARLQAMLDTDSGYGGSMAGDSVQGWHPRFTEDRPSPAHSPMVRGESSQAADNERRQQASAIHQLWYNQHRVALGRSINRVVETLKSLQEMNASWPATYPSVQRAEASQPQRRDPRPGLVHTQSTAAGATSLSEPPRPGSMRRSLTSIGENSTEPESSTAAEQRSVPEPRLITPQIAQEFSILKLDLKLGALHQTELVHSLEKNSIASLLDGKISTSIKHLLSLRDRIEDTSSKVLVTGDLNTGKSTFCNALLRRKILPEDQQPCTSIFCEVLDARENGGVEEVHAVHKDVIYDRHDESTYDVFVLRELERIVTDNDTYTQCKVYVKDVRTIDESLLNNGVVDISIIDAPGLNLDTTKTTAVFARQEEIDVVVFVVSAANHFTQTAKEFIWAAAAEKAYIFIVVNGYDNIRDKQRCQKMILEQVAGLSPRTFKESAELVHFVSSNAIPSAPPGPGGNGGGSGSASGGGGDGPEDDDGEPQGKGKGKEKEKIRDFENLEQSLRRFVLEKRARSKLAPAKTYLLNVLGDVHTLATVNQEVAQSELDRVTRELNELEPLLEASKKAKAEVSDDIDKTIEATCKGIYDHTRSTLTTAIAESGDEDLGVEYPGLFNAFQYAEDLKEAILSQISASVIACEEHARRRTVDGVSSIKQLGLLHLGDEYTDLSFRSDVMFTRKRDKLAKQVEIETELWDFFDWSTIIQKQEKMAGTGMAMTVLTVAGGRMLGGYGWIDGALAGVKVVGNNNLRHLIIPGILATAVAATAYILSQIPHSLPHRLSSKVSAQLEAIDYVHTNSDRISSSVRKVLRFPADNLRVGLQRSVEQLGTKQEETRKVKIESEVARKYFGNLVNESAKLRNTVEAVDLEGPAPGVAAAYDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9T2</accession>
    <name>A0A3D8T9T2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_00541</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9T2"/>
    <dbReference type="OrthoDB" id="252265at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18785">
        <property type="entry name" value="Inv-AAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="1">
        <location>
            <begin position="8"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW94778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="179" mass="19432" checksum="20CF6FF529535A51" modified="2019-01-16" version="1">MEPSISAGDHQSYMSYCLTLAQKSPPKPTNYRVGALLLDASQNKILATGYTLELPGNTHAEQCCFLKFLGKHNLPQDSEDRLAEVLPQNTILYTTVEPCGKRLSGNLPCVERILRIGKGGEGKGGIRKVYVGVKEPEKFVGENVGRQKLEGAGIEVVLVEGLEEEILKVATAGHVEEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8TAM1</accession>
    <name>A0A3D8TAM1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rhomboid-type serine protease</fullName>
            <ecNumber evidence="10">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_00721</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serine protease involved in intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="10"/>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8TAM1"/>
    <dbReference type="OrthoDB" id="2146116at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002610">
        <property type="entry name" value="Peptidase_S54_rhomboid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936:SF69">
        <property type="entry name" value="RHOMBOID-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="379"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="404"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="474"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="12">
        <location>
            <begin position="281"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="68"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW94958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="550" mass="60469" checksum="22B4041AE8313BBE" modified="2019-01-16" version="1">MAANEYYNSQAQGQHQPYYQNYTQEPRPSLPTYHSEAPSYHSQTPQSMGPSPVSPFEAPFDDHVYPLPNQNAAHDNFSRQDSQTSFGQDSRYYGQGGGGVPQDSTNSFSDNIPLRDQHSSPAKPYPEGTDHVYDAGESGMPPGVRSGRNKRRSALGSMFEGKGAKKRIPWVVYALTIIQTAVFIAEIVKNAQLTGSPIEIHPSFNVMIGPSPWVLINMGSRYVPCMHNVAGIQDSTVTISWGCPNTTSNSVADCTLSDLCGFGGVPNPNYNGDIKQSPQPNQWFRFILPMFLHAGIIHIGFNMLLQLTLGKEMEIAIGPIRFFLVYIASGIFGFVMGGNFAATGISSTGASGSLFGIIALTLLDLLYTWSERLSPWKDFAFIMLDVVISFVLGLLPGLDNFSHIGGFLMGLVLGVCILHSPNALRQRIGQEPPYTPVAQIKASDGDRPDAGVTGFVKSPVGFFKGRKPAWWAWWLIRVGALVTIFVVFIVLLNNFYIYRKTCTWCKYLSCLPVNGWCEIGNIQLTSTNTTSKRSVLDSWDAVAKLYLELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8TCC0</accession>
    <name>A0A3D8TCC0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_01051</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Monothiol glutaredoxin involved in the biogenesis of iron-sulfur clusters. Binds one iron-sulfur cluster per dimer. The iron-sulfur cluster is bound between subunits, and is complexed by a bound glutathione and a cysteine residue from each subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glutaredoxin family. Monothiol subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8TCC0"/>
    <dbReference type="OrthoDB" id="415696at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015036">
        <property type="term" value="F:disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02984">
        <property type="entry name" value="TRX_PICOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000012">
        <property type="entry name" value="Monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000092">
        <property type="entry name" value="Monothiol glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF73">
        <property type="entry name" value="GLUTAREDOXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="7">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="130"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00055846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW95288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="293" mass="31743" checksum="3BF99A0F2F39CA3D" modified="2019-01-16" version="1">MSTLQEIKTEEEWNAHSSSLPPSTLQIINFHAPWAAPCAQMTTVLQTLASQYPVTSPLQTSWVSMNAEEVMDVSEAFNVTAVPFLVLTRGGTVLEEVSGSDATKVREAIEKHSKSGAPTNGVSAATAEKKDLSQYAPTKTDPATAPGYSSGAVEQNKEDLHARLTNLVKAAPVMLFMKGTPSAPQCGFSRQLVALLRENSVKYGFFNILADDEVRQGLKEFADWPTFPQLWVEGELVGGLDIVSYIHTTPTSKAVGEEKVQILITFVLAQVKEEIANDPEFLKPFSVTKTAAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8TCD8</accession>
    <name>A0A3D8TCD8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AB hydrolase-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_01061</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8TCD8"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047372">
        <property type="term" value="F:monoacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046464">
        <property type="term" value="P:acylglycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="109"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW95298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="383" mass="42838" checksum="926CE6636095E217" modified="2019-01-16" version="1">MAPSFLQTATDWIRRSLKDAPRPLLISAGILASISLGVVQYQWAESISRRQRQPRIARSPLKDITSTLTEAEKSELPYPPDLFPGARDVDSPYGSLRVYEWGPEDGRKVLLIHGVTTPSIVLYKLAHILVERGCRVMLPDLWGRGYSDNPSDLPQDSRLFATQILLAITSSPLAWTGSSKFDIVGYSMGGGVVAAFAAYFPNLLSSVVLMGPVGLIRDHRIVAVRRLPRLAAYFPDWMVERAGRRFMQGLPEHGWPSLRVEGRPDVTERSVIRWLTNNHAGFTKAWTDSMFQCPAWGAETRRAWEKLGQTMLARKGGDEYDKVLVILGETDSVIVKEEFIEDALEVLGEQNVDICLLTGDHDFGFVQAEEAADTMFTFWSRKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q466</accession>
    <name>A0A3D8Q466_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Aflatoxin biosynthesis ketoreductase nor-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_13094</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000025">
        <property type="protein sequence ID" value="RDW56629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q466"/>
    <dbReference type="OrthoDB" id="9876299at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05325">
        <property type="entry name" value="carb_red_sniffer_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052184">
        <property type="entry name" value="SDR_enzymes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458:SF3">
        <property type="entry name" value="CHAIN DEHYDROGENASE (ATSC), PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45458">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE SDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW56629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="26520" checksum="CDC7E9A3E1F3EAFD" modified="2019-01-16" version="1">MAATSSNTVYLITGANRGIGLGLLESIISRPRTTVIAAVRNVDAASKSLSSVFVGEDSKLIIVKIDALSETDPAQAAVELTSKYNINKIDVLVSNAGLLGNIAPVLETSAQVVRDHLEVNTIAPLNLIKAFFSLLSASQQPRFFVLTSSIGSMANMEQFPVPFFAYGISKAAANYLVRKVHFENPSLISMAFNPGWVQTDMGNFGATSVGMAEAPVTIEDSIKGLVSLFDNASIEKSGSFTDVSGESVPW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q574</accession>
    <name>A0A3D8Q574_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Polyketide synthase-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_13038</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000024">
        <property type="protein sequence ID" value="RDW56971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901336">
        <property type="term" value="P:lactone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030639">
        <property type="term" value="P:polyketide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000209">
        <property type="entry name" value="Polyketide synthase Pks12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3290">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056501">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020807">
        <property type="entry name" value="PKS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049552">
        <property type="entry name" value="PKS_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF29">
        <property type="entry name" value="ASPERFURANONE POLYKETIDE SYNTHASE AFOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23297">
        <property type="entry name" value="ACP_SdgA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13602">
        <property type="entry name" value="ADH_zinc_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23114">
        <property type="entry name" value="NAD-bd_HRPKS_sdrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21089">
        <property type="entry name" value="PKS_DH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00826">
        <property type="entry name" value="PKS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="22"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="964"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2475"/>
            <end position="2552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="435"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="7">
        <location>
            <begin position="964"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1131"/>
            <end position="1286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="7">
        <location>
            <position position="996"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="7">
        <location>
            <position position="1196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW56971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="2563" mass="279033" checksum="1A0612BAD82B89E7" modified="2019-01-16" version="1">MAFSQGTDTNGDPPSPLACGDAMPIAVIGMGFVGPGDATNVEKLWTMISEGRESWTEIPKERWNHEAFYHPDPNRYGTYNVRGGHFFQQDLSRFDAPFFHMTAAEAAALDPQQRLLLECTYEAMENAGISMDQFCGTKTSVFAGAFCTDYTDILWRDPESTPMYQCTNAGNSRANLANRLSYFFDLRGASVSVDTACSTSLVGLHLGCQSLRTGDAKMALVAGASVILSHEAWVTMSMMRFLSPDGRCYTFDERANGYARGEGVGCVLLKPLTDALKDGDPIRAVIRGTGSSQDGKTPGITMPNGAAQEQLIRDVYARSGLDPAQTSYVEAHGTGTQAGDPLETGAVSRVFGATRSEDNPVRIGSVKTNVGHLEAASGVAGLIKSVLMLENEVFLPNRNFEKANPRIPLKEWKLEHGLSGRTSKVRSIRSDKTLQHTHPNLNGHSNGHSNGHDNGLNGHSNGHENGHENGLNGHPEEITNGNVRKHGRLFVLSGFDEVAIKKQTENLKVYLEERMDVADEAFLDDLAFTLSDRRTSHIFKTAVSAQSATDLLENLKGGINFGKGSKKPRLGFVFTGQGAQWCGMGKELLSSSEVFRHTLENITSYLLSIGAEFIAIDELQKDSKESKINLALFSQPLCSAVQIGLVNLLSSWGIKPDSVTGHSSGEIAAAYAVGALSFEDAMSVAYFRGLASSNLAKKGLGKGSMAAVGLSKVDVLPILEGLKLGKAVVACSNSPSSVTVSGDESAVDELLAILEEKKAFARKLVVEVAYHSPHMMAISDEYREAISGIKVQDTVGDIEFFSAVTGKRASTADLGPDYWVSNMLGEVKFDESLHILCTQTGAAASKKKRRSAGVGVDALVEIGPHSALAGPIKQILRADEKLNQASIRYHSTLLRKTDANDSILKLASELYISGYPLPLSTINQYKGTESVLVDLPPYPWTHTNAYWAESRKSKALRNRPFPRTDLLGALERTCSPLEPRWSNYIRLAEIPWVRDHVIQSNIVYPAAGYIVMAVEAASQRAIQRSVSGITGYKLREVVIGAALVIPEDLGEVEVAVTLKSYSDSMKSPSDLWDEFVISSVSGEDRWTEHCRGLVCIQTPSKVKNEVDGEMQRSRDRKYYSDIVNGHANRCQKEVDVAHFYEHIAKIGLEYGETFACMKAARSAPNACLATVKIPNTAAVMPKEFEFPFVVHPATLDSLFHTIFVAISAAAGDLKDPAVPVAIEEIFISTGISHTAGDELAVYTEADQKDHRSLSATMTVFSAEDRSEPVIFIQNINCATLESGTGQESKKELQRRAYNIKWRPDVEFLSPTALAELCQSHASPEQASFRHKLETCAFYLLQQAFDAVQQETRAFSGKYQEDLWSLIQRLVETTVDKHRNASSTDLTSASTDERASMLQEIKSSGAEGALLCHIGEQLPKLLTSETAYPEIVRSFDLGRLYAPSGIFLNCKSAARYIDLLKHKSPNLSIMAVGDLAGVTSIPIIAALCPSGNETLSFTKFEYVDPDFDLTEMIKARVPALQNIVMRNELDMGKDVALQNCNLKSYDVVIAFHVIGSAKSTRAIMANAQKLLKPGGKLLLIGRVMRSLAAATLFGFLPSILQKQLAIDPTDGPLSKDDWTQLLTETAFSDDASTANKEKQGAFFLTALPAATPVEHPEVLILVEEGQLDGLPKSLQKLLSETQLTAEVAIFSEANPKPSQICIVLSELSREVLANPSSKDWDALKKIFLDSAGVLWVTQGGTITPTQPNNNLIAGFARTIRSETGSLPFLTLDLDAKKPLEDHAAAHIILSLYQKHFVVGVDSQAIEHEYAERGGILMVPRLVQDEEVTKFIASSTEDPKPEMQPFRQPDRHLHMVVGSPGLLDSMYFVDDDRFESDLPDDWVQIEVRATGINFKDVMMALGQIKVKKLGWEASGVVTALGKDVTGLAVGDRVLCYGAALFSTDYRGPAPQFQKLPDHVSFEVGAALPVTYATAYYSVHHIARLQKGETVLIHAASGGLGQALIELCQLIGVEIFATVGTRDKKSFLMEHFKIPEDHIFFSRDGSFANGVKKMTMGVGVDVIMNSLAGESLRLTWDCIAPYGRFVELGQRDIMINTRLEMGQFNKNATFSAFMLDYLIEQRPHVASKVMADVMELFNSGSIKGPSPVQTFSICDIEKALRLIQTGGHMGKVVAVNHPGDQVKVLPRDTKKKLLKPDTSYLLVGGLGGIGRATALWMSAHGARNLIFANRSGLKSDEARATVQSLKDKGCQVAVYSCDITSADSVSAMAAQAAKEMPPIKGVIQGAMILRDGLFEKMSLEDYTTVMLPKVSGTWNLHRSLPPDMDFFVMESSVSGIVGNATQAAYAAGNTFLDAFCSYRNSLGMPATTIDLGAIADVGYLATNTELRDAMQRQGFELIDTNSLLSLIHFAIANPRRKEILSEVVTGLGVYQEGNSLSSLGLPLFSHFRLLSSSGTKLDSDDASARLRQQLRAVKSLEDASEVITTALVEKIASRSGADVGHIDTRNPISDYGIDSLVAVEIRNWITKEMDCTVPILELLANNPLSLLAVKIAQRSRLVQLETSNKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q687</accession>
    <name>A0A3D8Q687_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12991</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000024">
        <property type="protein sequence ID" value="RDW56924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q687"/>
    <dbReference type="OrthoDB" id="5376804at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35394:SF5">
        <property type="entry name" value="DUF3176 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW56924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="295" mass="33480" checksum="EAFF38BB8FDFE411" modified="2019-01-16" version="1">MDNYSMQINGSTSLPTLNYEEWGFYPIVKYTILNHHSHPRFVAAAEGVLYWCVQGYKSSVKAKVLSQNVTASWYDKHAVDPTSSTLTLSRPPDTWPSLGINKSNSFTVTDLVYYQSFVEESLDSSYIASSLDSSYIASSLDSSTASEVLSQILFNGVKNISSLFDFVASRMTNRLRSPVCDLTFPGVENNLDVLVIRWWWLITPTTVILLTIVLLATVIVQSHYHKVKLWKTSLLALLFHGLSVEIRNKYSMSEVKDLRKMEEVSEKVVVSLREQDRGDKETGLLLRNQYNQERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q6S9</accession>
    <name>A0A3D8Q6S9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">FAD-binding PCMH-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_12847</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q6S9"/>
    <dbReference type="OrthoDB" id="9983560at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050432">
        <property type="entry name" value="FAD-linked_Oxidoreductases_BP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878:SF91">
        <property type="entry name" value="FAD BINDING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G12070)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13878">
        <property type="entry name" value="GULONOLACTONE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017791397" description="FAD-binding PCMH-type domain-containing protein" evidence="3">
        <location>
            <begin position="21"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="4">
        <location>
            <begin position="118"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW57397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="591" mass="63533" checksum="6DF6BCA49FC74192" modified="2019-01-16" version="1">MVSLNHLLIATAIFSASASAQNTSNHCKYVPTDPEWPSSAEWDNLNQTISGQLIAVQPVAISCYPGPLFNNDTCTEVNSKWTKCAWQAEQPAGFCIDTGTLTCPPIVPPAVAGQNCTLGNNPKYVVNATCPAHVTAGIKFAQKNNIRLVVKTTGHDFLHRSEGFGSLEIWMRYHRTGIDFQKTFQSTSGCQKSNWTGSALKVGGGYQWSDVYAVAQENNIIVVGGGAVSIGAIGGWMQGGGYGPAAHEYGAGADQVLEAQVALADGSIITANACQNTDIYTGIRGGGPSTYGVVLSATYKTYPMVSTLTQSLFIPFTRATRSTYLDSLAVLYSSFPDLSDAGYAVFGFWGQSDASLHGSSPPGYFHTAVLFNTTVAKAQAAFDPVGQKLAAVGLNFTQTWTTYPDYWSLFSVMSATADDPGFPLGVEYARFFDKKALQGNATSLRDMLEVVAGAPEDGAIHSAACMAGGKVYKNFNDPYSGANPGWHLANCLQITQRSWASDESPALIASIKNDVTNVKGEAMMAFSPGTGTYMNEAGREDPHWKENFYGINYDRFLKIKKNRDPKSVFYCPTCVGSDEWAEDTTGRLCRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q987</accession>
    <name>A0A3D8Q987_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cobalamin-independent methionine synthase MetE C-terminal/archaeal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12271</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q987"/>
    <dbReference type="OrthoDB" id="7772923at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003871">
        <property type="term" value="F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009086">
        <property type="term" value="P:methionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03311">
        <property type="entry name" value="CIMS_C_terminal_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002629">
        <property type="entry name" value="Met_Synth_C/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038071">
        <property type="entry name" value="UROD/MetE-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844">
        <property type="entry name" value="METHIONINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43844:SF2">
        <property type="entry name" value="SYNTHASE, VITAMIN-B12 INDEPENDENT, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12060)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01717">
        <property type="entry name" value="Meth_synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51726">
        <property type="entry name" value="UROD/MetE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cobalamin-independent methionine synthase MetE C-terminal/archaeal" evidence="1">
        <location>
            <begin position="178"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW58341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="401" mass="45376" checksum="5EBB110EB08514CA" modified="2019-01-16" version="1">MSLTLSPPFRAEHLGSLLRTKELLDARDSKSTGRDQEQHVKEVEDKSIKEIVDIQLEAGFHGVTDGEYRRNLFWGTFFDGLDGFEEVPFDREILRTYMPNVGALLQAGYVPGGSLLCTSKIKHSRSTHVDEFNFLKNHLASKNLPINEIKLTIPSPASYHQRYKDGKAYAPGVYDSDQEYFADLAKVFQEELKVLYDAGLRNVQIDDPTLSYFCSKEMLKGWEEDSSNKRTANELFESYITFYNDCFSNVPSDMHIGIHICRGNFTDSRLVSEGGYDKIAVRLFQDLNVNTFYLEYDTERAGGFEPLKHLPKNKNLILGVVSTKTTQLEDVEELKGRVLAAAKVIAEGSDQTVEEALKRLGVSPQCGFASHSHENRLTRDQMVAKLKLVRKVADELWPAES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q9L5</accession>
    <name>A0A3D8Q9L5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Amine oxidase</fullName>
            <ecNumber evidence="14">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BP5796_12238</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a primary methyl amine + O2 + H2O = an aldehyde + H2O2 + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:16153"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:17478"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:228804"/>
            <dbReference type="EC" id="1.4.3.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="14">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="14">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="13">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Homodimer.</text>
    </comment>
    <comment type="PTM">
        <text evidence="13 14">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="14"/>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q9L5"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.98.20:FF:000006">
        <property type="entry name" value="Amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.40:FF:000014">
        <property type="entry name" value="Peroxisomal primary amine oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016182">
        <property type="entry name" value="Cu_amine_oxidase_N-reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015800">
        <property type="entry name" value="Cu_amine_oxidase_N2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015802">
        <property type="entry name" value="Cu_amine_oxidase_N3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008559">
        <property type="entry name" value="PRK11504.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF86">
        <property type="entry name" value="COPPER AMINE OXIDASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02727">
        <property type="entry name" value="Cu_amine_oxidN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02728">
        <property type="entry name" value="Cu_amine_oxidN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54416">
        <property type="entry name" value="Amine oxidase N-terminal region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0186">Copper</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 12 14" id="KW-0801">TPQ</keyword>
    <feature type="domain" description="Copper amine oxidase N2-terminal" evidence="16">
        <location>
            <begin position="33"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase N3-terminal" evidence="17">
        <location>
            <begin position="124"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Copper amine oxidase catalytic" evidence="15">
        <location>
            <begin position="251"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="13">
        <location>
            <position position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF02727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDW58308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="686" mass="77243" checksum="57B3588AA147A706" modified="2019-01-16" version="1">MVANTSIAGQAYEREQASSCCSSKSNGLSRPEHPLDQLSIHEISEATRLIRQDAALKKLKFNSITLREPLKKEYVTFRDQEGPRPDRKAFAIVLEAGTCNVAEVLVNLTTNQVEWWKDVKDVMPTLTLEDLDVTEKIARNDPRVIEACKEIGLTDMSRLYLDAWAIGVDDRWGFETRLQQGLAYYRSSLNDNQYAHPLDFSVTVDTEREEVLAVDIRRVNGERTAIPIAEHNYLPEFISDQYRHDLLKPVEITQPKGVSFTMNGNVISWCGFSMHIGFNYREGIVLSDVCIDDPYEKRKRPIFNRISVAEMVVPYGEPGAPHHKKHAFDVGEYGTGFMTNSLKLGCDCKGAIQYLDGVVSTSQGEAAVIQNAICIHEEDNGLLFKHTDFRDGKVISARARKLIISQILTAANYEYALYHIFHLDGTYQFEVKLTGMLNTYCLHPSEEAGKYGTQVAERVTAHNHQHIFSLRLDSEIDGPNNTVVQCDAVASEAEVGSAENFYGNGFYCRQTPLRTAKQGAQEYCHETSRTWNITNPNVLHPVAKKPVAYKIVSRESPPLLAKPGSVVWNRAGFARKALWVTPYRDYEVFPAGDYVCQSTGADNHASNRTIIDRVAEDESIDNTDIVCYLQFGLTHFPRVEDFPIMPAEPVSVMVRASNFFERNPALWVPPSHEDQPGESILVHRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QBH7</accession>
    <name>A0A3D8QBH7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_12005</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QBH7"/>
    <dbReference type="OrthoDB" id="3598674at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052895">
        <property type="entry name" value="HetReg/Transcr_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24148:SF73">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_8G01020)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW59081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="515" mass="58416" checksum="7464001CC068198C" modified="2019-01-16" version="1">MPQIYRDAKEVLAWLGPFAALPYSHWYNEDEGAGSYIVSMRALSRDRGDGGLVGLVGSGSKTVSVLTVLKALLNRSYWQRTWVIQEITLASTVFLICGDFLVDPAVLNYFRPFASREMEDPEYDTDNDLGLIRPSKELQLSMGSRLLWDIFRLSVFERSLYQYGSGRRVESVEGYRVENDAEIFARIQRDIHGITRSKGYILDEHRKSVRADTLEELLWTCHGSTCSDPRDKIYALLGLASDCQSGEIEVDYSKSLFEVYKDVVCFYGRSHSKPESQYMPKVVSFSQHLQRVFGSEPILQEMSEEENSKMERFSTGCIKAQGILTGTVFRLKEVPKYSLGQECRQSSMDATNLDDNFFDSLQNILTLSPNNSFGFFPVCTTGDGSWQPPSVPSRTKTAYQSEDGVRFLNFQMENGRTGIISANARKGDIICQFLDCDVGAVLRKHSNKSTFSVVGRAIIRKSEKEGLLEGNLSWDEVRWRQFTHSVPYFDQDTGPPMDRIINLELDIVTLQQLTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QDS0</accession>
    <name>A0A3D8QDS0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Carboxypeptidase</fullName>
            <ecNumber evidence="13">3.4.16.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BP5796_11592</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Release of a C-terminal amino acid with broad specificity.</text>
            <dbReference type="EC" id="3.4.16.5"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the peptidase S10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.16.-" evidence="13"/>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW59986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QDS0"/>
    <dbReference type="OrthoDB" id="443318at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000328">
        <property type="term" value="C:fungal-type vacuole lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004185">
        <property type="term" value="F:serine-type carboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.410:FF:000001">
        <property type="entry name" value="Carboxypeptidase Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001563">
        <property type="entry name" value="Peptidase_S10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008442">
        <property type="entry name" value="Propeptide_carboxypepY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018202">
        <property type="entry name" value="Ser_caboxypep_ser_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802:SF113">
        <property type="entry name" value="SERINE CARBOXYPEPTIDASE CTSA-4.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11802">
        <property type="entry name" value="SERINE PROTEASE FAMILY S10 SERINE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05388">
        <property type="entry name" value="Carbpep_Y_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00450">
        <property type="entry name" value="Peptidase_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00724">
        <property type="entry name" value="CRBOXYPTASEC"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00131">
        <property type="entry name" value="CARBOXYPEPT_SER_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13 16" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017740946" description="Carboxypeptidase" evidence="14">
        <location>
            <begin position="16"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="Propeptide carboxypeptidase Y" evidence="15">
        <location>
            <begin position="15"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00052076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF05388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDW59986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="539" mass="59977" checksum="53FFED37C3C36664" modified="2019-01-16" version="1">MKLLTSTALIGAASAASMQQVLQNTFEAAKPASESWAKPLHALSDAMKDMTAEAKNVWDEVAMLFPEAMDKATFFSAPKPNTRKPDSTWDYVVKGADVQSVWIENSNGEKEREIDGKLDTYNLRAKKVDPSKLGVDTVKQYSGYLDDEDNDKHLFYWFFESRNDPENDPVVLWLNGGPGCSSLTGLFLELGPASIDKSGKLHSNPYSWNANASVIFLDQPVNVGYSYSGGSVSNTVAAGKDVYALLTLFFKQFPEYAKQDFHIAGESYAGHYIPVFTSEILSHKKRNINLKSVLIGNGLTDPLTQYEHYRPMACGDGGWPAVLDAGECQAMDNALPRCQSLIQNCYDSESVWSCVPAAIYCNNAMLGPYQKTGQNVYDVRGKCEDTSNLCYSALGYISDFLNKKDVMASLGAEVSSYDSCNFDINRNFLFQGDWMQPFHRLVPSIIEKIPVLIYAGDADFICNWLGNQAWTESLEWPGQKDFNKAEIKDLSLGGDKYGKIKTSGNFTFMQVFAAGHMVPMDQPENSLDFFNRWLGGEWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QDT5</accession>
    <name>A0A3D8QDT5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_11585</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW59979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QDT5"/>
    <dbReference type="OrthoDB" id="3552456at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="404"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="671"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="466"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="507"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="527"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="567"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW59979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="693" mass="78781" checksum="074A3871BEF72256" modified="2019-01-16" version="1">MSSFEDMTKWGRPNPAPPLLQAHPWSYQHLPGLDQLLGYQNNDNYVRLDQSSTIDDFLVHLCPVMLGLVCNDQFIEQDLHKARCRRCQIQHGPYSTFYQGIFDETAGLEENPENDGEILARFCYDRQSIDSYLLWKYPKEEDADEDTEEDTEEDSEDGFSDRPGSTTPTSPTSQERRLWMNDARFWNGFGHDESEDDSEDESTEESAEQIVGIWKFGEGDSEQDSEEDSEKFHQSAASYYSEYGFTAGEEAKYARNRPFRPTSPQSLRHIPAPTTGKRRRAPYEESDTDNDPPPKRSRRVPIESIMSGVQSIERGVQRSVRDKTSTLSQQPSKNCIDHTNKPVIMFQDTEIIDYVYYDGAWRSMGKLDLTLQMWSDMTKGDKDTAILFENHTELLQPKPRIKALSLHTPSGGRRRLRGRTGSTRGAATFKDPIGNSQFNFHKDEGKQRGEDEQEDEENGALNRASGTKDVRRSRVHFHSRDKSEASLKFAPYSSSSISLARASTSANLSSPSRSVTWTGDDDDDGEREGKGCDRGGTRIQKDDESDKDFVPSKIRAATGGGRRRNTSSEQAALPQSSTTVSNASMVQASTGTRRRPRRPAWSEDETNILIQEYQYHLQEERNRGVGEHQKLRDMRLHQKLARQLETRGVRRTAGAIKNHWTRVCRQMSGLDERTARKDGQARAMVTSAQPRRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QEC5</accession>
    <name>A0A3D8QEC5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TIGR04076 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_11693</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QEC5"/>
    <dbReference type="OrthoDB" id="2838513at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023811">
        <property type="entry name" value="CHP04076"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR04076">
        <property type="entry name" value="TIGR04076 family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW60087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="117" mass="12696" checksum="D18778035439BE1F" modified="2019-01-16" version="1">MATESPSDAFELYDLRVEIVCPPGEKIICGAKAGDHFTLEGEMLHLPAGQGISIYSLSAVLPLLAAKQRMTHKNDWMSTDALVACPDPNCKSQLRIVRTGIRTFRHGETTVVGLDGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QES1</accession>
    <name>A0A3D8QES1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal peptidase complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_11833</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QES1"/>
    <dbReference type="OrthoDB" id="29558at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009582">
        <property type="entry name" value="Spc2/SPCS2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 25 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13085:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06703">
        <property type="entry name" value="SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="71"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045608"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW60227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="231" mass="25703" checksum="8E836ABF814AF60E" modified="2019-01-16" version="1">MAAPEKISVYSLNDLKNTSDDAIPAYLNSLKFKQSHTLSDVRLALGYSAFLICAACFYWDYKFGFESTKIYTTIAVALYTIINSALTLWIWGVEKGIIYVGTTPNGEKIEITTSVKKHVPVYNIVVKTTSKSGKTKEIKFKREFRKWFDAKGNMVAQPFQQLWASNVECIGMVDQKNIVRTKEEGKKTIEVAGKDASMDEKWASLLAESQPGVTGVETESGTASKRGKGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QF08</accession>
    <name>A0A3D8QF08_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_11844</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QF08"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11062">
        <property type="entry name" value="CYP58-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050121">
        <property type="entry name" value="Cytochrome_P450_monoxygenase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305">
        <property type="entry name" value="CYTOCHROME P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24305:SF157">
        <property type="entry name" value="N-ACETYLTRYPTOPHAN 6-HYDROXYLASE IVOC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="7">
        <location>
            <position position="456"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW60238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="517" mass="58740" checksum="EFE340B0D02F1E05" modified="2019-01-16" version="1">MLSLHDFPPWLSLSLGAVFVYTIALAIYRHYFHPLARFPGPKLAAATYWYDSYQDCIAGPFPGQGAYHIEKLHEVYGPIVRVNPDEIAVKDPYWYDTLYNSGRRDKWLRNHKANGSPGSLAQTAGREAHRLRKAPLLPFFSKRAVTELEPVIKQKVSMMCDGIAGFLKRGEPLIAGRAFTALTLDVITDYCFNKSWECLQDPQFSPHWKATMCGLFEPVPFMKQFPIMAQMMNLLPRSLVKVLLPEMALFLGGRDAVHEQVERIVEERKTTGKEKSATGLEGPRTVFHALLDSTLPAQEKEVDRLTDEGFVMVVAGAETTSKILSTIFYHILANPSHLERLRSELDKVMPNPEDLTDWSILEKCKFLTACINEGMRISNAVTNRLQLMDPTETLKYKEWAIPPNTPISMSIPFILMDPTVFAEPKTFTPSRWIQNEEKKENLERFLIPFAKGSRGCLGQNLAMAELYLATAAVVRRFEFELYDTVRERDMESVRDCFVGLPMPGSKGLQVRVVKKRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QHT2</accession>
    <name>A0A3D8QHT2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Phosphogluconate dehydrogenase NAD-binding putative C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_11257</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QHT2"/>
    <dbReference type="OrthoDB" id="9988102at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015814">
        <property type="entry name" value="Pgluconate_DH_NAD-bd_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09130">
        <property type="entry name" value="DUF1932"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosphogluconate dehydrogenase NAD-binding putative C-terminal" evidence="1">
        <location>
            <begin position="241"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW61365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="341" mass="36801" checksum="F653C97534E8E930" modified="2019-01-16" version="1">MIPPKYPNRLAPQHADATFGSGVGTSLLPPVDKSLSSADKPIVAIFSFGEMGMGIAALLTKFLYRIVTNLDGRSAKTKARALAIGVEDLPLEKVLNEASIFISIVPPAEALPLAQKTAAAFQLLPCSEKQDLTYLDLNAISPGLARQVGQVIIGAGMTFVDGAIIGFPPKELEDKTWFRPAITTSGPQLDDQKSTFTTQLVSLLNVRHVGDEIGAGSGLKMCFGAIYKDQAAVATQAYTTAQSLGVLSALRSHLGKYFPTSTPIIESSLVGSQRKAYRWIKEMEEVEDTFAEGGWSRDLFRGVSNVFRVVAHKTNLEQQSKEDVEVITGEICLGLRRTKCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QHU2</accession>
    <name>A0A3D8QHU2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NCS1 nucleoside transporter family protein-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_11267</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QHU2"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.4160.10:FF:000001">
        <property type="entry name" value="Uracil permease, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012681">
        <property type="entry name" value="NCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00800">
        <property type="entry name" value="ncs1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="136"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="301"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="387"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW61375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="541" mass="60238" checksum="A1017308AF384CA5" modified="2019-01-16" version="1">MSKEHTTYESEPVGISTGYSHENNSLWTKFKGRATLQVNDSRMAPGSRFSNSDLDPVEPEFQTWRTYNFVMYWISDAFAVSNWRIGSSLIAIGLSWKLALVAVVIGNFMTALVVTYNGLIGARLHIPFTIQARSAFGFYFAYVMIILRIIISIFWYGIGTYTGAECIQSMIYAIWPQFRNIPNKLPESANITTGFMICYLIFWIVCLPFHYIPAHQVRWFFTFKGIVTPIAGFAIIGWIVRSTGGGNALFVQGNSVSGAKLGWSVMQGIYAMVGNFATLGVNMNDFARYSKKPNSPYVQLIVIPIVFVVMMLFGIIGANGSKILYGELLWDPLQIINNWTSKGGRAGAFFCASAFLIASIGVNISADSISVAIDLSALFPRYVNIRRGQYICAILGAWAMTPWNILVSADSLINFMDGYTIWLAPISGILIADYWIVHKQVVSVPEMYQPDGIYAYNRWGTNWRAAVSFFVGFAPLLPGFAQSVNSKLNVPEGAINFYALGYFYGFFVGGGLHVLLSKLFPPKETMLHKHGVGVHRDDYEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QIA4</accession>
    <name>A0A3D8QIA4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_11359</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QIA4"/>
    <dbReference type="OrthoDB" id="10256055at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW61467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="444" mass="50550" checksum="6B012127A0FC7C30" modified="2019-01-16" version="1">MPKERAAGRANVTIGRQGCDEALPFCERCVAYGLDCEGYGSKRVAFRNQTQANTLSSKAMVMRAKPRVAISLPSIALPAGQRSLLHDFINGFASSRALSPVQNFYKDDIAPLAMEHEHVRSAILALTAAYTNNHRGAETFKSYQDAVQLFRLSLKDTANRQADLACMFILTWFEILIFDPENWKTLLELDGGRDANDSNMDSVAVGACERLYGIVGATIYLNDEWMQSPMVDTEFQTRAFAIIQRLDKWYASLPKELHWSDDNNELSRRSHLQKMILLHYYSIKVHIFHMVDPLRLGLWNDSMVLARRCLLLIRAIGPPSKATQTDYKGDLGVPFAFAVVGVYFDDKEERQWINDYLFELGRDTVWCGYERAMCLRAWWQSSVSGKRLLMSRPKREDAPWDWKPEMGMNVGILYEDLKTGTLGRDSYFLNGSQKDLVLLPARQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLB2</accession>
    <name>A0A3D8QLB2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">CFEM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BP5796_10803</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
            <topology evidence="2">GPI-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RBT5 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLB2"/>
    <dbReference type="OrthoDB" id="2496787at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098552">
        <property type="term" value="C:side of membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008427">
        <property type="entry name" value="Extracellular_membr_CFEM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF160">
        <property type="entry name" value="SAT4 FAMILY MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05730">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00747">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52012">
        <property type="entry name" value="CFEM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 14" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0336">GPI-anchor</keyword>
    <keyword evidence="12" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="8 17" id="KW-0732">Signal</keyword>
    <keyword evidence="7 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="17">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017574125" description="CFEM domain-containing protein" evidence="17">
        <location>
            <begin position="21"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="133"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="215"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="CFEM" evidence="18">
        <location>
            <begin position="5"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="401"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="410"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="33"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="37"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="47"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="14">
        <location>
            <begin position="56"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022622"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS52012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RDW62501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="446" mass="48852" checksum="7613A22968217FBD" modified="2019-01-16" version="1">MRLISSVFLLGVAFIGFCQGASLAELASQLPACGLSCMETAISQSSCTLANTTCICTDTTLLASATACVATSCTVKEELKVVKIQQDGCGVPVESQQTKVKIVANLFCALAEICVILRIWTKLQLTDRLSPDDWMIVVSGILIIPYWYFGDALVGLGLGLNMYDANIDTLTKYFLYFWIDELLYLNLLAVTKVSLLFFLVKIFPSRTFRVTCWSVGALCVGIAISFSAATVFSCHPISHVWDEWQGSAVSGTCNNINLQTYIAGAINIVQDFTILLLPLPELYRLQVSMRKKVQLFFMFSVGLLYDIPPPLLHLDYVEVVIWSIIESTLGIVCACMPSLRQLLGQCGSGGLFGSTDKGLSTAGNSRIYQSRSYKIENKLRSQNDEFHELASITNGNSGNASSFHTIHKASSPSISESSQQQATLDGREDEQKGAAHVWVKHQSIHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLM0</accession>
    <name>A0A3D8QLM0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative potassium channel beta subunit protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_11025</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the shaker potassium channel beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLM0"/>
    <dbReference type="OrthoDB" id="1720422at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034220">
        <property type="term" value="P:monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005399">
        <property type="entry name" value="K_chnl_volt-dep_bsu_KCNAB-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150">
        <property type="entry name" value="HYPERKINETIC, ISOFORM M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43150:SF6">
        <property type="entry name" value="VIC POTASSIUM ION CHANNEL, BETA SUBUNIT (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01577">
        <property type="entry name" value="KCNABCHANNEL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0407">Ion channel</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="4">
        <location>
            <begin position="25"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW62723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="346" mass="38635" checksum="4CB977456FDBECF2" modified="2019-01-16" version="1">MAPPEGLPKMEYRFLGRSGLQVSAISLGGWLTYGGHVENENTFACMKAAYDVGVNFFDCAEGYSGGDSERIMGEAIRKFGWKRNDLVISTKINWGQAHGDNPVNNGGLSRKHIIEGVDGALERLGLNYVDLVYAHRPDRNTPIEETVRAFNYVINSGKAFYWGTSEWDADEIATAWRYAEKLNLIGPVMEQPQYNMLARNKVEKEFEHLYEETGLGLTIFSPLKIGILTGKYNEGIPEDSRLGSSTDVFVKRMNERFGDENWKKDIEIVKKLKPVADKLGMTQATLALAWVLKNKRVSSAITGASKVEQVYESVKALPAVEKLTPEVMAELDDILGNKPAAMVRRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQ33</accession>
    <name>A0A3D8QQ33_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">p-loop containing nucleoside triphosphate hydrolase-17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_10438</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW63936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQ33"/>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000008">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000034">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="167"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="20"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW63936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="390" mass="43583" checksum="ABD0098F3359812D" modified="2019-01-16" version="1">MADEERQHALASFKAKLLESREWEAKLKALRQDIKGLQKDFNQTEENIKALQSVGQIIGEVLKQLDDERFIVKASSGPRYVVGCRSKVDKIKLKQGTRVALDMTTLTIMRMLPREVDPLVYNMSLEDPGQVSFGGIGGLNDQIRELREVIELPLKNPELFLRVGIKPPKGVLLYGPPGTGKTLLARAVASSLETNFLKVVSSAIVDKYIGESARLIREMFGYAKEHEPCIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQLDGFDYLGKTKIIMATNRPDTLDPALLRAGRLDRKIEIPLPNEVGRLEIMKIHAAGVVIEGEVDFESVVKMSDGLNGADLRNVVTEAGLFAIKDYRDAVNQDDFNKAVRKVAESKKLEGKLEYQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQP2</accession>
    <name>A0A3D8QQP2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NAD(P)-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_10638</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQP2"/>
    <dbReference type="OrthoDB" id="1669814at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE (AFU_ORTHOLOGUE AFUA_6G11210)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43180:SF63">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE FAMILY PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW64136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="247" mass="26120" checksum="11DDDD72B5F78990" modified="2019-01-16" version="1">MGDTPNPATSPFNLNSKLIVLTGGASGIGLATAHLLASLGAQLSIGDLSASALESAAQSIKAQTGKDVMTMVIDVRKRDTIELWIRETLAWAGRERLDGAANLAGVIGKNHGKMSVGFAPFLFFVIGVPGDLRWFGFVFYSAVLCLGMLLCGWKWFLHCPSVIQNTEDDEWDFVMDVNLKGVMNCMRAELAVMAENGSIVNAASICGLQGLKNAGAYCASKHGVIGLSRAAAKETGEEGIRVNCVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QR80</accession>
    <name>A0A3D8QR80_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ chaperone (Caj1)-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_10680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QR80"/>
    <dbReference type="OrthoDB" id="442087at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000180">
        <property type="entry name" value="WGS project CABT00000000 data, contig 2.6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948:SF21">
        <property type="entry name" value="DNAJ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="8"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW64178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="233" mass="25072" checksum="27D4B7C2271B7967" modified="2019-01-16" version="1">MSRGLPSDYYAILGIASSATQQQIRDAYKKAALKTHPDRVPSDSPERPERTKKFQKINDAYYTLSDASRRRDYDAARQYHGFGSGASTASTAFDSDEEIPDPAAAGAGTGSSFPWSSFGFKAKNQEEEQKFENEQFGDVFEEMLKEEGMAENGGTPTGKFWSVVGGLSGGAMGFIVANFPGMLAGAVAGNRLGNIRDARGKSVYSVFQELPQGDKARLLSQLASKVFAHAVGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QRG0</accession>
    <name>A0A3D8QRG0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_10586</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QRG0"/>
    <dbReference type="OrthoDB" id="3553609at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38848">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38848:SF3">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTORS FAMILY 3 PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW64084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="361" mass="40729" checksum="A609F46C02953D11" modified="2019-01-16" version="1">MVLGYGTQANRPCKLARIICLVFYIGHKLPLYAFLVERTHAVRSVTRRRLQDWFYISGMISVTLGFISIVVSLCIWDGWFYEPASGQCQIGFRLPVILALLVFDVMVNLWLTWVFVHYLRPYLTKGVLNAFVPKGIGDLMISRVFKHATPNTDFDISFAIPQADLIRVIRNTLIGCIAMCAATVANCLVLIILHSHEEVWMLFTFCTLDVTWTVLIINWLTNISKDVLASPITEPDSEDPLVRNDRLARTANAREMAQYASVFSSPENIMEIFDVEHSTLNGLRSEPRRKLSRSRKSTGVTGAGDEISLMDAVLEDMFASSGRDRVVQRARATQQPQKSEFSGCGVHRPQIADAVWRLGDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QTX6</accession>
    <name>A0A3D8QTX6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_09985</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the THADA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="73997at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056843">
        <property type="entry name" value="THADA-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056842">
        <property type="entry name" value="THADA-like_TPR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019442">
        <property type="entry name" value="THADA/TRM732_DUF2428"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051954">
        <property type="entry name" value="tRNA_methyltransferase_THADA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387:SF0">
        <property type="entry name" value="DUF2428 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14387">
        <property type="entry name" value="THADA/DEATH RECEPTOR INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10350">
        <property type="entry name" value="DUF2428"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25150">
        <property type="entry name" value="TPR_Trm732"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25151">
        <property type="entry name" value="TPR_Trm732_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26523">
        <property type="entry name" value="Trm732_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like TPR repeats region" evidence="6">
        <location>
            <begin position="249"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="domain" description="DUF2428" evidence="5">
        <location>
            <begin position="765"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA (32-2'-O)-methyltransferase regulator THADA-like C-terminal TPR repeats region" evidence="7">
        <location>
            <begin position="1008"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="604"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="686"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="613"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW65293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1733" mass="193579" checksum="44819118D7566EC8" modified="2019-01-16" version="1">MTDLSPPACKEDGVSDGNCPQDDKLIVKWLENQPISQALLAREQLNGFLDRAAQPRHASGNACIKLCYFVEQCRASNSSHIREVAYSQRTCVDLFNFFIEWNEKNQNRSMRQILDLLASLLLKHPEQSTAQSIKTLFIQRLISIVSHQASQPLVKPAFKALECFLTKKTFSAEELFFVYQEERVRVGASNDEKPSVIDIQSWDDFVSEVFDWMALPDIAPAAGKFLVTLFRELRRDSTESSSYATGHAQLWQRWIRDGLSKDPDALENFKNYLFPPLFKLDRDGSLAFLEDLNKQKPMSELKSLDLTAHSFLQLAALEAGKKAGLVEEPGWYKILLLYTQLTDQATIQFHKAPKKSAKVIVLQEDAIGSVITHSSTSVRSLALSVLVSSSSTIRPFSPTALDILQRSLGILHADTDAKFRNEVLGNTKQFVERLRGSTAFLVREIESLSFVPKTEEDSQRLHSSPANSPIRTTVGQTEVKDPFLLEEAGKLLSRHEKFIEWYVEFLMGELAPTCSYQRHITSLRAIGLLLKSGILGQAGAIQAGKVTDDSTIWPYNIRFFTTVAMRLFLDLLMDPFEDVRSSATGILKFASRDCFTIQPLSRNTSQSSLSRRQSTDRGLEKQPRRRQSQAELLDAFTQESKEHWNSRPMGLLMDFIARAEGLSKRTGRADYADGVARAYELLYGLLDTEAARIDLVEDLIRQLERKISIAESDLARAVLVAPVHGQFAALNFVWEVIDHIRISKRTSVDLSIIQESCKAWDDLQWRILYACSRIWEAIKDVLCNDSPEGHLPQDLDDVDDIDTKDVLSYSFRATHESRQVKTCNLMRTMIGKIKSQWQDGSPILPAGLFADIGNLTFNQLASLRHRGAFSTVSLTFSRCCQLALHQSQEEKEALNLLEQWYQGALGCIYEQVSTTRRSAGIPALLTGILSANTSTPSFQDVMAELKDLAKQNVKLSETDETNLPQVHAMNCLKEIFKSSALGKRAESHIADCLHLAADSLSSEIWAIRNCGLILLRSLIDALFGTSESKLIAEAGWDGRSIRLSYDKYPALPELLLKLLDAKVDSVHTVFPSIGAVESVFPALDIIRRAGPPGTQRERIYSAVSTHLGNRVCHIRELAARTICNLMLHDDWLPAVSELIKSCDISANRTHGVLLAISFVLDRRLALKLDLNTGDLVQCLSLLTDSLHSSSTIGNCSELLAAYFEVLNAFQRIITRLERPTKNPTVLQSTFSCIIPSDVPQQLEKLTKTYSMSAKNPRSSALLRKAIARKAVYIASLTDNLEVLEMSLYVGFADVDTTLAMFECISVVFNEHKDVKSLQALVDLYVKALPSSRSSEVRARALFQLASILDRISLAGHKLSIGLLTQLPRIGALLQDGKASPQLSKAQLRLSGCLFLHEHSCNDTSEESTRDSCDKEQLEQRLEVWGQCLTAAGHANNDFDTRFAAVQGLSSFYSYIETSILNPAHLPSLFALYDTLNDDDDDVRDAGAACTSALLGRSLVPLAAAKDFLQWLWKSQGSSPSFAWNVVCRMTGNQDEALNVGQWHLRSAEAQLSEAMAEDESLFVEEEQNLFFDEIREAKVWSVLFEKELHSNWSNPVSVLATWVLEGLAVLNLLATKNDGPLGWTSKPAVFAQCMRIIISAKALLRYQASCTIAQFGDEKASKTRLKVPEDTTDKIREELDMLISLSSDKQLHESLIYEILGWPALVLTSSRGAKQAGRRRTLPRRQNSSYSNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUQ3</accession>
    <name>A0A3D8QUQ3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Nucleoporin Nup82</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_10197</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUQ3"/>
    <dbReference type="OrthoDB" id="341482at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037700">
        <property type="entry name" value="NUP88/NUP82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257:SF0">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP88"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13257">
        <property type="entry name" value="NUCLEOPORIN NUP84-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="79"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="731"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW65505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="868" mass="96942" checksum="DDAD3EF848368BC9" modified="2019-01-16" version="1">MPKVTGYTPAWLSKPEPGFDLFTASSEDEKHALSLNGKGTSKPGPRRTIAHRGTEVFIAVGKEIRWADLVYLKETWEDKQHAQKGQARGKERESSQTEPRDGNAQGYRTIKTPVADDIRQLVISPTGNYLAILTTHTVHIALLPESSHLTAPDTGPMRLKTYTLGPTTHVTSQSGIASALWHPLGVNGTCLVTVTEEAVVRIWELSTTDRWSFDRPTLTIDLKKLADGTSLDQDFGASISGINKAFSPDSFEMEVASACFAGKGSGGWSPMTLWIAMREGDVYALCPLLPEKWSPPPTLIPSLTVSIVAKNAAMEDDFDIPESHKLLAQQQLAWFSDLDNQDPVHIESSMGEPPGTVYTRPAKPGKVPRLQGPFELDLAPEESDDELNDLLTDIFVVGEKIDAEQLMYGEEEELEMDDAEQEGLSAGIICLLTSSGRLSICLDLEGVEAQWLPTSKSRYSRFVQDIEIPSLLTFQVMETSRSGEIWEGSWPVFSPDVESRYSFYITNTSSITFVSLVPWVFRLETEMNEGNEGTDFRIELIAKQSSIRERVFTQKMHDTSAPLTASNLISDPDLGYFLLSATSHGPLALSFESPEAEMGLVRRERSPTYDSEPDKPLILCEPRPVYQPPHALAMSSGLTKLREKLGHSKYKRLLNEEVRMSPATLTVFTDVHKLLSEETHRLGSAAAELFRRCQRLQVDLQTQIRRANEVASRVDAITGNDTDDGPAISANERLEERIQAAQDRQKQLAARIEKMRKQVTKGTNRELTDKEKVWVEEIHNLASKVLKEHEGDATEDDNVPWRRYEEVEHIKEELLDQVSTEAQMAPSPHIKVPSEVRRVKMAKIKDLLDRESALVEATKNRLERLSMS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYN5</accession>
    <name>A0A3D8QYN5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Dihydroxyacetone kinase-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BP5796_09529</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13941"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.28"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>dihydroxyacetone + ATP = dihydroxyacetone phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15773"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.29"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Polyol metabolism; glycerol fermentation; glycerone phosphate from glycerol (oxidative route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dihydroxyacetone kinase (DAK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYN5"/>
    <dbReference type="OrthoDB" id="1724672at2759"/>
    <dbReference type="UniPathway" id="UPA00617">
        <property type="reaction ID" value="UER00669"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004371">
        <property type="term" value="F:glycerone kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050354">
        <property type="term" value="F:triokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019588">
        <property type="term" value="P:anaerobic glycerol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1180.20:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10440:FF:000001">
        <property type="entry name" value="Dihydroxyacetone kinase, DhaK subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10440">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1180.20">
        <property type="entry name" value="Dihydroxyacetone kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012734">
        <property type="entry name" value="DhaK_ATP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004006">
        <property type="entry name" value="DhaK_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004007">
        <property type="entry name" value="DhaL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036117">
        <property type="entry name" value="DhaL_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050861">
        <property type="entry name" value="Dihydroxyacetone_Kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02361">
        <property type="entry name" value="dak_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629">
        <property type="entry name" value="TRIOKINASE/FMN CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28629:SF1">
        <property type="entry name" value="YALI0F01606P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02733">
        <property type="entry name" value="Dak1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02734">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01120">
        <property type="entry name" value="Dak2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82549">
        <property type="entry name" value="DAK1/DegV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101473">
        <property type="entry name" value="DhaL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51481">
        <property type="entry name" value="DHAK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51480">
        <property type="entry name" value="DHAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="6 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DhaK" evidence="15">
        <location>
            <begin position="11"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="domain" description="DhaL" evidence="14">
        <location>
            <begin position="390"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="528"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-hemiaminal-histidine intermediate" evidence="11">
        <location>
            <position position="223"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="56"/>
            <end position="59"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR612734-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDW66780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="595" mass="62464" checksum="4544447EBCB76E37" modified="2019-01-16" version="1">MSTKHYFPETAVNTLVPLALKALVTANPALSLIEDQRVVLNSNHNPAHVALISGGGSGHEPAWSGYVGDGLLSAVACGDIFASPSMKQVLTAVASVPSDKGTILLITNYTGDKLHFGLAAERALAGGFSKKCAVLPATDDVSIGRSKSTKVGRRGLAGNVITMKILGGAAAKEYSFEKCVEIGKAVNEQLVSIGSALDHCHVPGRQNHDTIDDDVCVVGAGIHNEPGAQRISPFPSVEDLISQLLKLICDPNDPERGYVKFSTSDEVVLLINNYGGISPLELGALTQETLNQLDTTWKILPTKIYSGAFETSLNGPGFSITLCNISAAASNSQTSPAELLTLLGAHTTAPCWPNVLSNSSTKEPRKAVPDVDVEQKASVDSSQDLKIEAGLLEKSIRTACEKAIASEPDLTRWDMVMGDGDCGEAVKGVSEATLQLLDSGIARSGSIYEVLYAIIDAVDAMGGTLGAIFGILLAAFASSLQSQSQTHSSNTPLIDILAPALTSAVTSLKQHTGARVGDRTVMDVLLPFAESLDRERNLEKAVKEAERAAEGTKGMKPGFGRASYVSVEKGEGDGIPDPGAWALYELCKGLLEGSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYT6</accession>
    <name>A0A3D8QYT6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Acyltransferase 3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_09698</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYT6"/>
    <dbReference type="OrthoDB" id="5819582at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050879">
        <property type="entry name" value="Acyltransferase_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23028:SF134">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G08520)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="442"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="2">
        <location>
            <begin position="67"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW66949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="494" mass="55664" checksum="BA250FDB21918790" modified="2019-01-16" version="1">MAIADQNMDSNCKPRVLADGPVEERTRARANVLGNKLFSLSRNILPSFVSSIGSPTRSPPPLHATSYLDGLRGIACVILIFFHFFAHGYARVNHGYKTGKPADETFFQLPVLRLLISGPAALRVYFVVSGFAISYQPIQRMRAGDTIRLCDSLGSSALRRGVRLFIPLLVQTILAEWFAYNGLVGMSFPPQPKNPSAMAFIKHWWVSISTLFVRTGADSTKGIGYSLQIWTIPIEFRNSIAVYLAILAFAKTRECYRVPLKALLVIWLLYRSNPFLSLFQGGSLLAELHHMRGERREYLTYLESTTTPAGDFMKAFAQVVRRLPPWLPTAAWTWFALFCAFALSRPCNPEETPGYQWLATKFAYAVLNEELAYLIAALGLVFCIDNCEDLQAPFNSAPAQYLGKICYSLFLLHWLLIQTVFHPFERRLMKARPDISRGMHHVFGGILLVPLLIWAADLFWRLVDRRAVAFSKWLITATQESPEPSARVGSEKFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QZ32</accession>
    <name>A0A3D8QZ32_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetyl-CoA synthetase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_09670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QZ32"/>
    <dbReference type="OrthoDB" id="10253115at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF30">
        <property type="entry name" value="AMP-DEPENDENT SYNTHETASE_LIGASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="1">
        <location>
            <begin position="43"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="2">
        <location>
            <begin position="429"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW66921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="545" mass="59275" checksum="11561E85D85B6E6F" modified="2019-01-16" version="1">MVSKTTYALFKLGAVLFYTNRFAQITLPCFVVKQNGVDWRKQVPLNPAFNSKQVIAALVHLSASHLIIGAETSLPYKAPRENVTLLSQIVPNLAGSKCESPAVPSLCNVILVDNSSSRVDVRSLSATTPFADLLSSSRGGQSVVPDSILNPDDIVNIQFTSGTTSMPKAASLTHRSILNNGFFIGERMGLTPSDVVCCPPPLFHCFGCILGYMATATHGTAILFPSEAFNPEATLLSIQEEEATALYGVATMFVAELELLQNGTISNTGFDKLRTGIAAGSSVPSRLMEKLHNTLNLTGLTICYGMTETSPVSFMTTPDDPIQKRLDTVGRLLPHVEAKVIDVSDHTRILPIGEKGELMVSGYLVMKGYWGDEAKTQEVRKIEKGADGTEKIWMHTGDEACMDEDGYVKITGRIKDLIIRGGENIHPLEVENILFAHEHIAEASVVGLPDEKYGECVAAFIVVHKGVLVGKDDAGNGLPDETITSSGSRNLTAKEAKEWVRNRLSSHLVPKYVFWVEEYPKTASGKIQKFKLKEEGLRLLGLVQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R2P9</accession>
    <name>A0A3D8R2P9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08848</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R2P9"/>
    <dbReference type="OrthoDB" id="3543169at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015969">
        <property type="term" value="P:guanosine tetraphosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05399">
        <property type="entry name" value="NT_Rel-Spo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055496">
        <property type="entry name" value="DUF7068"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007685">
        <property type="entry name" value="RelA_SpoT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46844">
        <property type="entry name" value="SLR5058 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46844:SF1">
        <property type="entry name" value="SLR5058 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23238">
        <property type="entry name" value="DUF7068"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05729">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04607">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00954">
        <property type="entry name" value="RelA_SpoT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NACHT" evidence="1">
        <location>
            <begin position="360"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW68191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="807" mass="93164" checksum="2F507C1697218814" modified="2019-01-16" version="1">MADVQISQSLKVFDDQSTFYNNLKDKVDKFSEKLKDKGIRHFWQSRVKTAQSLKGKLQKRKEKGQSVNLAEIFDLVGGRIILVKSGDLKVVEEILRREFYFREKIHHPTPEEHNISSGQSAPRFRIYDASHFRLSLNEGNEGAMNTVFEIQVMDIIMWTFYDIEHDIVYKGNKPISKELRQALEILQGSSNMLAAVRQQFEAVLEDRHQDVTSRLEASNGLSQKFRQDIQSLEGALVTNQVVVDPETHRVLERVLQGILGALAEKRYKPSDVVEALFEHYSALDRLKIERISGDPLPMDQCYLNLAIIERSKEKATYEQKSPFALFARLKVHEVDTNAQVTLRSLFNRRKLPTGETITPKRILIQGDAGIGKTTLCKKIVYDYIHNDMWRQSFDYLLWVPLRQLKGKVEPTYNSQTLCHQTFFSTNLYGDVLARTLAEFIDSPNSTAENPRVLFLLDGLDEVSDEIDSGKNNTCIGSFIRNLLLKPNVIMTSRPDRFNRAYLGSLDLELETIGFNQDQVAKYIDNRRIVKELETAEQIKAFLAKNPLMQGLVRIPIQLDALCYTWNRELFLKDMPKTMTTIYHAIVNKLWQKDILLLEKKDQGQLLNANAIKDLTTQSQIETIAQPENDLLQGFAFIGLYNNVIEFNAMHRRQIHGYLQKQNRSLPVFHSSIFKSLSFLRTSDNSLPDSEQNYHFLHLTFQEFFAAQYFVKQWTKKGKLSCLTLVKSEPETIDPESFLRRYKYNSRYNIFWRFVAGLTQSTEDKAVLEFLQLLEAEPRDLLGPTHQPSETILKTSYFAGYYSNAASR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R2S5</accession>
    <name>A0A3D8R2S5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ankyrin repeat-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_08996</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R2S5"/>
    <dbReference type="OrthoDB" id="426293at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051020">
        <property type="term" value="F:GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15473">
        <property type="entry name" value="Myo5p-like_CBD_DIL_ANK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002710">
        <property type="entry name" value="Dilute_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037986">
        <property type="entry name" value="Myo5p-like_CBD_DIL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052072">
        <property type="entry name" value="Vascular_dev_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027:SF6">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16027">
        <property type="entry name" value="DILUTE DOMAIN-CONTAINING PROTEIN YPR089W"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01843">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01132">
        <property type="entry name" value="DIL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51126">
        <property type="entry name" value="DILUTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="169"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Dilute" evidence="3">
        <location>
            <begin position="392"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="501"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="692"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="739"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW68339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="821" mass="92156" checksum="4ED1E4A9BE90075D" modified="2019-01-16" version="1">MDIGDNGGDIGFQNEGEIKRPRALPDDLPKSLDDRKSVPTHFTTETEMYDAWQGQSQFLTTPVLAKPLQFNSLSLDDNGYDDDLTSQKVGDSDSRLMEMLAAQAAHRDGSASEDENAVVSNDKLSEDEKKDILQKALNMAASNGDVERIQRLLSGDAKSYVDVNAPDEEGTAPLIYASCFGHDAVVDALLDAGADVDKQDRNQWSALMWAMTNRHKGIAKSLLDHGASPEVKSSSGRTAFDFVAPDSEISGYLHDSGYHIGSVGVTDDFYNPGFSQDRFEEEMAENELRRRMMMESARDLEVDLGNVGIDDQPESPEELEEEGQEFDWSRCLHDQMFVFQESELFQILDIIITKMTPQRSPSQKPVPANMIFLSARYAHYHANQELLAKLLISAMDKINDVVEKNQWDMTILAFWISNATLLLHYLKKDAGLAQSTTEFQQQLSELINEIFILIIRDAERRIDKVLDSAILDHETIPGFEDITFQNEWKIFKRKNQVREAPLEKRFRPPSPKQRAKPSPRNVTSLLSSTLFVLDLYDIHSVITAQILAQLLYWLGAELFNRVMSNRKYLARTKAMQIRMNISSLEEWARSNNRQPEHYENGSMTSTGETTVDAARRHLAPMIQLLQWTQCFSSLAMDDLEGLVGTLQQLTRLTPQQLIHAVKHYRPEVGEKGLPKSAMKYLINLQKEAQLRKERSKNIAASPNSTPKKGAAANGDGSEAPGLDKKPVVPNTINPPPLEEPLDDGDDAPENLLLDPAFMLPFSLPTSTDMLVSYGAGFGGLNRERERKYIPTVPPEFLAKLDLSGGRAQSTYGERDWENEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R3E0</accession>
    <name>A0A3D8R3E0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CWH43-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_09127</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R3E0"/>
    <dbReference type="OrthoDB" id="10032492at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019402">
        <property type="entry name" value="CWH43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050911">
        <property type="entry name" value="DRAM/TMEM150_Autophagy_Mod"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324:SF2">
        <property type="entry name" value="EG:22E5.9 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21324">
        <property type="entry name" value="FASTING-INDUCIBLE INTEGRAL MEMBRANE PROTEIN TM6P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10277">
        <property type="entry name" value="Frag1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="7"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="CWH43-like N-terminal" evidence="6">
        <location>
            <begin position="6"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW68470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="280" mass="31662" checksum="9DC8A4E3F2D0E668" modified="2019-01-16" version="1">MWGVSYWVFPIISALCWLGMLLGLLISWNVDGRPHLASMDATQHIAYISDVGAGHLKPLFIAGSCVTTVFLDLSFLSERLLRHNGRLARNTTMIEKVLSGLSMVFALIGTAGLILLSIFDTLRHHMLHDIFLLLFIVGYVVSAIFICWEYQRLGIHFREHAVLRNSFWIKLVFILIEVVLAIAFATCNFKSLFNAAAVLEWAIAFIFTFYVLSFFVDLIPAVHTKGHRFSNETEMQYEANDHTSAVRQYPAGRNTVDSQRTLTNTEVMVERPKPAMGSNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R848</accession>
    <name>A0A3D8R848_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08629</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R848"/>
    <dbReference type="OrthoDB" id="3437826at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW70232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="133" mass="14604" checksum="CC759884E1EE1C45" modified="2019-01-16" version="1">MSSALGYSQPKSRSRTSSPHPNLATARRPKLVRASATAPSVAISNASRKDLSNHQSARAAAILSRVASYSSQQTSPGGTCMTPGQRSLSMERRKEPFVMASSQSGSYFSFPSFEDFQDYQDDLRRSEHRNEKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R850</accession>
    <name>A0A3D8R850_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carboxylesterase type B domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08517</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R850"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carboxylesterase type B" evidence="1">
        <location>
            <begin position="3"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW70120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="300" mass="33011" checksum="A3CBADFA55BBEBCC" modified="2019-01-16" version="1">MDSGTLYPTDDITSPQAQDLYDQVVLEAGCDSSSNTLDCLRNTSYAELSTIIQNMPNCLDYTGIALPFPPRQDPNDSFYSFSVEVALRAGNYTRVPIITGDQQDEGTIFTTAMTNITTPSLLADYLQVLWPNSSQSIRQGLVDGYSTDPADGAPFGTGSLNQLYLQYMMNAALIGDAAFTLQRRNYLLMVSTTVSSWSYLDSHRYGDNPSGTYHSSHTEEIFNTAQIEVNTAARGITADTFRSYYVSFTHYLDPNAINAHLAPHLLASLHHLGSSIAESPCRWQHSDSGRPPCGKRRVSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8Z1</accession>
    <name>A0A3D8R8Z1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ASX DEUBAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_08827</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8Z1"/>
    <dbReference type="OrthoDB" id="3533911at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028020">
        <property type="entry name" value="ASX_DEUBAD_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13919">
        <property type="entry name" value="ASXH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ASX DEUBAD" evidence="2">
        <location>
            <begin position="80"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW70430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="171" mass="19191" checksum="C9B4DB6D793661ED" modified="2019-01-16" version="1">MVGRRKKLTGVKRVTTRPTSRAPKRTKLAKILDDPQAALENEDSPIFKDEVNLKAVLSHPKAQEVLRAAGLDCDIYKLPDFATAAARFKEDGSSGRHDPEWQRQALEASERRAAGEFDAYHKERFEQEWLGLDDSEDKLSSVTTKAHDMSNGEARQDVKTSEEQDSSIHEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RC64</accession>
    <name>A0A3D8RC64_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_07681</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RC64"/>
    <dbReference type="OrthoDB" id="10471925at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW71647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="422" mass="45455" checksum="1928AA84B2359109" modified="2019-01-16" version="1">MGRLLPKEQLHIFQNHPFGLGHKQEGKDKGENRACAEEEEHAALNPRHHIRQGIHDDKLGEPLHAPRAHHAEAAHVGGKNLGAEDPRDAGPRKGVADSVEIEGGDGGIGAPNAPNQEWDATAEAVDDENHEDESDDKLDDAIEARGEELEGIYAREVLEHHQRHADEDSTPDAAVFEMRQAMKDGLLAAGHFGFVGDLALDLIDLLLHPGMIRRKIAHPGQVFERSLVPALRDQPTGRLDDERHGEDEEAGGNELDRHRNVPLSVGGVRNAEFHPVVDPEAAERRTGQHDLEDADQATADRRGRAFRDINGNDHGGGAHTEPGDEAPNVEDLDVGEEVQHHAHDKEDAASGHRPFPPVSLRQEGADDDAEERAALEDTHDVGGLGSRHGAREPERSLKGGQGDGPADEGGAIAIHGTGLASG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCU0</accession>
    <name>A0A3D8RCU0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NDT80 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_07907</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RCU0"/>
    <dbReference type="OrthoDB" id="4117572at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.1390:FF:000007">
        <property type="entry name" value="p53-like transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1390">
        <property type="entry name" value="NDT80 DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052605">
        <property type="entry name" value="Fungal_trans_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024061">
        <property type="entry name" value="NDT80_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037141">
        <property type="entry name" value="NDT80_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008967">
        <property type="entry name" value="p53-like_TF_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144">
        <property type="entry name" value="MEIOSIS-SPECIFIC TRANSCRIPTION FACTOR NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35144:SF1">
        <property type="entry name" value="PROTEIN PACG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05224">
        <property type="entry name" value="NDT80_PhoG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49417">
        <property type="entry name" value="p53-like transcription factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51517">
        <property type="entry name" value="NDT80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NDT80" evidence="4">
        <location>
            <begin position="81"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="NDT80" evidence="2">
        <location>
            <begin position="81"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="300"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="425"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="305"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW71873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="508" mass="55896" checksum="EBEEAE6ED64C3B24" modified="2019-01-16" version="1">MAAPNDVLRLSASEPSSHTIMSIGMDAFDHDLSFDGDSLLDDVQNHGLPSLPFTPSYELSDAFSTTFEDPFSYQSAPFETLVDDQSNADNGDTNQNDPDNKMLGFGAPIMKAPVLDETGQTWPSMSAELYGMFFVAEDVFGGENAGRPMELTCYRRNLFQISGTVTLSRTISHMLNEQGQQVPLYDLQATISALESIEGKATEIISVPWKTSAIASSEDKAGAAPPKWPLDLSMSPELDPSCVSIPIAWKRLQFKHATANNGRRKGLQQHYVIQINLMATSAAGESVKLAEIQSGPIIVRGRSPRNFDSRKDVPLNERKIESKSRTTSDTSSTPAKVDPHQAYRYYAQNGLNNPGIQQMPLELPDWTSSTSVAADTARPTKKHVISSYTTPRPPVPKTKWKNEPIDMKAVRTTAPIDLSLADEDSSRAKAGSIRHGPPASPQLSRKIVSSPVESADLLYEYFPMSLDDWMPPVDAIYRPHVVHHTIMPPDLKAAQVKNKTKRYFSADD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCW4</accession>
    <name>A0A3D8RCW4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2og-Fe oxygenase family protein-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_07923</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the iron/ascorbate-dependent oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RCW4"/>
    <dbReference type="OrthoDB" id="288590at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044283">
        <property type="term" value="P:small molecule biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.330">
        <property type="entry name" value="B-lactam Antibiotic, Isopenicillin N Synthase, Chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026992">
        <property type="entry name" value="DIOX_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044861">
        <property type="entry name" value="IPNS-like_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027443">
        <property type="entry name" value="IPNS-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050231">
        <property type="entry name" value="Iron_ascorbate_oxido_reductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47990">
        <property type="entry name" value="2-OXOGLUTARATE (2OG) AND FE(II)-DEPENDENT OXYGENASE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03171">
        <property type="entry name" value="2OG-FeII_Oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14226">
        <property type="entry name" value="DIOX_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00682">
        <property type="entry name" value="IPNSYNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="3">
        <location>
            <begin position="196"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW71889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="339" mass="37513" checksum="893D147CE9CDCDE9" modified="2019-01-16" version="1">MPSAINSAGDGAARKAFHIPTVDISPYLVDPSSAASQALIQQVAEACITTGFFQLVGHGIPRQLQQAVFEGSAAFFRLPFEEKKKLDKSHSVGSSNRGYEILGNQALQEGTLPDLKEGFYVGQEIPLDDPRVQAHAFLMGPNLWPPSSMVPEDVFKKPMQEYWQLMFSLSLKVMDVLAAGLPYGPHVFDEFVSNDAVASIRLLHYPPQKASSELQLGAGAHTDFGAITLLLQDHNRGLQVWNAEDETWVDVEPNPDAYVVNIGDMLSRWTSGKYKSNLHRVINQSTKDRYSVPFFFDGNIACELWPLDGSKIEGPVLTVEGHMKERFTTTYGRAKTTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RD02</accession>
    <name>A0A3D8RD02_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome P450</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_07884</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RD02"/>
    <dbReference type="OrthoDB" id="1103324at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11065">
        <property type="entry name" value="CYP64-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002401">
        <property type="entry name" value="Cyt_P450_E_grp-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050364">
        <property type="entry name" value="Cytochrome_P450_fung"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300:SF8">
        <property type="entry name" value="CYTOCHROME P450 2E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46300">
        <property type="entry name" value="P450, PUTATIVE (EUROFUNG)-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00463">
        <property type="entry name" value="EP450I"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00385">
        <property type="entry name" value="P450"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0349">Heme</keyword>
    <keyword evidence="4 5 6" id="KW-0408">Iron</keyword>
    <keyword evidence="2 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="3 6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" description="axial binding residue" evidence="5">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR602401-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW71850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="388" mass="44214" checksum="B8C8E6B83B1217B9" modified="2019-01-16" version="1">MPAMANSYQPAQSHESKRMLHDLIMDPSQYEFWLERYAGGLIFRIGYGMVIKTGKESYVRRALEVVHTVERVASPGSYVVDTIPALRFLPEFMAPFKKEGRLLHASELDLFRSLLGEVQERMAKGTCPSCFMKTFLEDQESFQLSDDEGAYVIGSLFEAGSGTTASAMMSYILAMTIHSEWQEIMVEELDSVVGDRMPEFDDIPQLPTIRAVIKEVLRWRPVTAGGVPHQLIKDDIYEGYFFPAGVNVHANQWAIHREQELYPDPETFNPHRWLKPEFPTFKEPLTKFPSLQNYSAFGFGRRICPGMNIAERSLYILTARLAWACKISKKKDAQGNEIPVPLYNYTEGFNVQPKPFDFSLVARSEKRARAVSEAWESAEKEDLLSLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="8" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RD57</accession>
    <name>A0A3D8RD57_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_07934</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RD57"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW71900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="67" mass="6890" checksum="4B8CD8CB416F2DD9" modified="2019-01-16" version="1">MRFVNCTIRPKLRQVPRTHVNSHGAGLHTVPAKGGRGNGCAPMLTAQGHANGAASGHRTAGRALPVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDF0</accession>
    <name>A0A3D8RDF0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_08111</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDF0"/>
    <dbReference type="OrthoDB" id="5367487at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47431">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="56"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="18"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW72077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="621" mass="69363" checksum="DE66AB6171BA013E" modified="2019-01-16" version="1">MDAFSTYSSQNPLPLAMGDSSPSQGASDSSNPASRGTSISIPGPTLDTNRVTVPSACVACRSKHLKCDGLSPCSRCSSNSFECVYVKSRRGFKGPRKKDKENVSPSTDSCDLLRRPGQAASVNGSTFSNGLATPPDHRRLSHPHVTGDGSFSLHGQDLGALGAIQFNPDFPPSDLPERCFEAYYYYFYPSHPFLLPKSHFLKLRQQKSMHHIDAAIRFVGSLYVPQAPTELYAQEAERAIYQIGAARDAFRVQAMLITAIGLDGNLEREKALQILTEAENLAMELGMHTRDFSLMNGAEQKVLEESWRRTWWELFIIDGMIAAVHQQSSFRLSEVVSDVPLPCEENEYASGHIPASHSLQELDDDCFTADDFTFSSFAYRITAMRNTGRVMKLGDLRFVDEATVDRADAYLVNWKMHLPATKKTFITNDRKVDEMLFQAHMIVEATTILLHRDHSQLDFSPAKDITSCAPYHASSPGEQYNTHAAKMIQSAQNVSRLISLPTEITKHSMFFTCVITLASIVHLSVWSVMMPLIQDTDIKEQLKLNIGAMKDLWRVWPSAGKAFGEVKGVAQDIYTAKKQAAQVGMWDHFTPDEIIRNMIEDDRIMEEFQEPQSDTQLALRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIH7</accession>
    <name>A0A3D8RIH7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin-conjugating enzyme E2-16 kDa</fullName>
            <ecNumber evidence="1">2.3.2.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">E2 ubiquitin-conjugating enzyme 1</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Ubiquitin carrier protein</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Ubiquitin-protein ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_07136</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="11">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.23" evidence="1"/>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIH7"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061631">
        <property type="term" value="F:ubiquitin conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd23792">
        <property type="entry name" value="UBCc_UBE2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000010">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2-16 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="12">
        <location>
            <begin position="1"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00074661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00077197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW73694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="147" mass="16526" checksum="5042378D5B679C48" modified="2019-01-16" version="1">MALKRINKELTDLGRDPPSSCSAGPIGDDLFHWQATIMGPSDSPYSGGVFFLAIHFPTDYPFKPPKVNFTTRIYHPNINSNGSICLDILRDQWSPALTISKVLLSICSMLTDPNPDDPLVPEIAHVYKTDRSRYEATAREWTRKYAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIJ2</accession>
    <name>A0A3D8RIJ2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative LRO1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_07190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIJ2"/>
    <dbReference type="OrthoDB" id="190846at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003386">
        <property type="entry name" value="LACT/PDAT_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11440">
        <property type="entry name" value="LECITHIN-CHOLESTEROL ACYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02450">
        <property type="entry name" value="LCAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW73748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="668" mass="74418" checksum="C13F34E23718B1EF" modified="2019-01-16" version="1">MSSLRRRLGDKTPSSTPSAPSQEDPSSPQAEDVRLAPVSKIGTDTVTKSKHRKRRNGFIFFLGGLFGIVVAGFFANRNDLIEIPELADLSITNFMDALPAGMVKDARDLAIGEREATNYDSFSVGLRLVAQGMHAEHPVVMIPGVISTGLESWGTSNKSRPYFRKRLWGSWSMMRALVSDKEAWKRHIMLDKYTGLDPPGGIKLRAAQGFDAADFFITGYWIWNKILENLATIGYDPSNSFTAAYDWRLSYANLEVRDQYFTRLKSYIEMAYKVTGKKAVLVSHSMGSQVLFYFFHWVASPNGGDGGDSWVDDYVDTWINVSGCMLGALKGVPAVLSGEMKDTAQLNAFAVYGLEKFLSREERAELFRAMPGISSMLPMGGNAVWGNGSWAPDDPPNTNATFGSFINFKTYNGTSYKNMTVEESLEYLKNTTEDWYVKQLEGSYSQGVAHTTKEVNENEKDPRKWINPLETRLPLAPNLKIFCFYGFGKPAERSYFYRNEPSPLTSLNVTIDTSFSQGPTVNPPSDGGAVVDHGVILGEGDGTVNLLSLGYMCNKGWNMHRYNPAGVKITVREMPHEPDRFSPRGGPNTGDHVDILGRQSLNDLILRIAAGHGDEIAENVTSRIREYSDKVKIWEEDAYISKEKEEDTSSSEDQNGLFEKIVDKLEHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIP0</accession>
    <name>A0A3D8RIP0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Programmed cell death protein 2 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_07282</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIP0"/>
    <dbReference type="OrthoDB" id="443682at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007320">
        <property type="entry name" value="PDCD2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47524">
        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47524:SF1">
        <property type="entry name" value="20S RRNA ACCUMULATION PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04194">
        <property type="entry name" value="PDCD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Programmed cell death protein 2 C-terminal" evidence="2">
        <location>
            <begin position="221"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW73840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="354" mass="38496" checksum="B0C9BDEA3E621169" modified="2019-01-16" version="1">MVLLLQLNGDLPEIFPGHERRLYVFSCRRKSCRRIDGSVRALRGIRTAEVIPSVQKSDTISKAPVSEATKPSINIGQTLFGGSSSIGASSSNPFSTTPNSGLKNPFSSPGSSISLKPAPPPAAAKPADVEPPSTSTTVDLPQSFASALSLNMPKLGPPPPPEPWPQALPPAYPLYYLADADYEILDKIGDLPVPGQTMQIDEDIGSSSQKEDKVVYESTIDKTFQKFADRLAQNPEQVIRYEFKGQPLLYSKHDIVGKLFTGEKGHEKVQTSSGSGNKLPRCGNCGTSRVFEVQLTPHAIMELESEEMSIDGMEWGTIIVGVCEKDCQQQHLNGDVGYVEEFAGVQWEEMKSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIV8</accession>
    <name>A0A3D8RIV8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_07425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIV8"/>
    <dbReference type="OrthoDB" id="2285229at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057912">
        <property type="entry name" value="OB_CYT4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056625">
        <property type="entry name" value="SH3_CYT4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056624">
        <property type="entry name" value="WH_CYT4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF65">
        <property type="entry name" value="EXORIBONUCLEASE CYT-4, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G01550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25522">
        <property type="entry name" value="OB_cyt-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23214">
        <property type="entry name" value="SH3_CYT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23216">
        <property type="entry name" value="WHD_CYT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="2">
        <location>
            <begin position="518"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="647"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW73983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1016" mass="114111" checksum="7452E04F81E3CACE" modified="2019-01-16" version="1">MLRIPRLKPVESFVSRSCLARLPSGVPTAPNFRHTRSLNAAANEPQISQITAFGNVTAAKPKKRNTIREQLSFWESENAQTSEPALDPANLASPGSIRNNLTRLTDGIETVIADQQWDTSITESHGGQEDRLNVGDRRSFLLAGDLVDLGGRGSQQSELAIFIQEYENQAQYYTMSGRWMHKFSKDVGFFVPGFASKAEVDELRPYLPQTEVSAEMQDKLHAFDRSVPRTVGGGLVQNMVKFMADADTIYQTAAFKLDTAHRHMAFERIYRYVTLEDIADALLQGTVKKSKNGRYSQPALYAVHRAIVSNEIGFQFQMRGDHKKGGRYEVAPLREVSNVYAVAEDVRLFVQGKISKEKVAAKGKHLNFLKFVNKAQKMIDRSRASRSLTPYGMVGPFSKNSEDSEQSVALDTEEDFDESDGQYIMFLESWAALRSFSLTSAFNGTGSNILRALDRYNDQMNLNQTTAWVCLQEIGVIPPWEDPAAYLLRLPKTGRRLRTAREGQGQHVWREDTLKNLRESFDAPVYCIDNVNAHEIDDGVSIESTEIADQYWVHIHAADPSCRIDPDSAIARSAKSFAQSIYLPETVTPMIETAYMRANLSLRRGARCLTFSAKMDKDGNILETKIMPRKLKRVMFFTPKVLDEVIQGPSSPQAKNTIRVGPDLPLPPPSRKMLSVEELSEKDQSDLRVLHEIGQAHAAKRASRGGLSTKMSNSMTSVSIDQSLLPSHSGYSSVYAGEPTIDFAADYHDPSSDHTQVETVQNLMLLGGEIAARWCRDRAIPIPYRVTAYNPDLEDPRTYFKNTVLPSLDSHGNVPDDIAMKYFQLCGKVLISSEPGPHMTAGLELYTKCTSPLRRYGDLLVHWQVEAAMLEEARIGESLIGSSREDYLPFKKADLDAMLPDVAIQERLSRIGMRYAQRAWFCQLLVRAWHFKETPLPKTFEFVVRYKTPQGEAGGILPFFLQNCVCRTVEKDIGEEVSIGDRLEVELKHVDVYEGHVDVRALRWLAPDEKVSTERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIX9</accession>
    <name>A0A3D8RIX9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nucleolar protein 9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5 6">Pumilio domain-containing protein NOP9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_07358</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIX9"/>
    <dbReference type="OrthoDB" id="392571at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040000">
        <property type="entry name" value="NOP9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00024893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW73916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="726" mass="80295" checksum="13CA37C25479401E" modified="2019-01-16" version="1">MPKENKHSRGRRDEKKRKRDGGDAEEAQSTKRQRSQEPAVEEHIPVAGTDNVVAAEDGVESSERPFYGLLEDEEQEYFRRADELLELNDFPSSEERSMFLANVYREAEGKELKIACSQSCSRLMERLILLSSPEQKKKLFERFSGNFAHLIQHRFASHCCETLFIQSAPMVTQELTGDVEVPMETKDDEVFVSMENLFLYTLNELEGQMTFLLTDRFASHTLRVLLVILSGRPLEQSSTRTLLQSKKKEKIGVNGLDTALTPLTLNKRAVPESFQFAVEKIISDTVATMDTSFIRVLATHPTGNPTLQVLLELELTNPNSKKGANSSQKTIISALLPDDITKPESESATFINGLIYEAIGSRLLETVMTFAPGKLFKQIYRSVFKERIAALARNEIASYVMIRVLTRLSKEDLEEAITSILPQIEGLVSRNRTTVIKTLLERCEARGADSEELTKSISAAYGDEPSTLVFKMADVDLDTLTKATAVPTEQTETKAMPPPRTTPQQLHGSLLAQAMLKIPGPPCTLLQNALLTLPTSTLLTLGLYTTTSHIIQAALEPTPTNTTFRRKLVNNLLATSIEDTVLRLATTSTGSHTLDALFQGTAGLQSLKEKIAFQLLAHEAELRDSFSGRIVWRNWMMDLFKRKRGEWVSKVKNGEGGSSASAGFISKAAATHEETAALKEKDSKGGKAAAGGKKKTAIELAREKFAKTKLKKQAVKEGKATGANAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIZ3</accession>
    <name>A0A3D8RIZ3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">2-keto-4-pentenoate hydratase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_07454</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIZ3"/>
    <dbReference type="OrthoDB" id="74910at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018773">
        <property type="term" value="F:acetylpyruvate hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019752">
        <property type="term" value="P:carboxylic acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.850.10:FF:000003">
        <property type="entry name" value="Fumarylacetoacetate hydrolase domain-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.850.10">
        <property type="entry name" value="Fumarylacetoacetase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011234">
        <property type="entry name" value="Fumarylacetoacetase-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036663">
        <property type="entry name" value="Fumarylacetoacetase_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820">
        <property type="entry name" value="ACYLPYRUVASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11820:SF7">
        <property type="entry name" value="ACYLPYRUVASE FAHD1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01557">
        <property type="entry name" value="FAA_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56529">
        <property type="entry name" value="FAH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fumarylacetoacetase-like C-terminal" evidence="3">
        <location>
            <begin position="20"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW74012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="231" mass="25064" checksum="0323847C21A89ED9" modified="2019-01-16" version="1">MPAKLYALGAIMPKLTLSSDHITELNSAKPKQPFFFIKPPSSILTPGAGPVIRPRGVDLHYEVELALIIGKQVKDLEPSDEKGAMDAIESYAMSIDMTARNVQNEAKKKGLPWSIAKGFDTFLPVSNVIPKSAIPDPHNAEVYLTVNGKSKQLDSTELMLFRIPRILSDISKVMTLEKGDIVLTGTPKGVGSVVPGDVMKAGIKVAGKEIEEGTIEVEVQESTSTYQFKET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIZ7</accession>
    <name>A0A3D8RIZ7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative metal homeostasis protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_07263</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIZ7"/>
    <dbReference type="OrthoDB" id="10003116at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048471">
        <property type="term" value="C:perinuclear region of cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030001">
        <property type="term" value="P:metal ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031398">
        <property type="term" value="P:positive regulation of protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22212">
        <property type="entry name" value="NDFIP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019325">
        <property type="entry name" value="NEDD4/Bsd2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13396:SF5">
        <property type="entry name" value="NEDD4 FAMILY INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13396">
        <property type="entry name" value="NEDD4 FAMILY INTERACTING PROTEIN 1/2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10176">
        <property type="entry name" value="NEDD4_Bsd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="240"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="240"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="271"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW73821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="345" mass="37165" checksum="410695F1F75E42F0" modified="2019-01-16" version="1">MSSTRYERVAAHDDDTPTTPRSPPPSFRSRASSPNSRHESQTTVNQTLADTFDADGSDSEEENDGDDRQRLMRGTPVEVSSEEVTMETSANGERPARVQRRVTHLPAFYPPVSTPTGRVYGGGSGSDGVFANLSAKPETGEKTEEHPPTYEQAAADAAPPYWETTILAPGLGGPDEVYVDGLPVGSVFSFIWNGMISMSFQLVGFLLTYLLHTTHAAKNGSRAGLGITLVQYGFYMKGSSTSTPSNGQDPQYTQPPDPNSHDFDPSQVDQAAAASMDSSSSGGIGDIASSEWLAYILMIVGWFILIRAVSDFLKARRHEQLVLQSPERGLSVPVIASDEEAETVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RK59</accession>
    <name>A0A3D8RK59_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_07663</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RK59"/>
    <dbReference type="OrthoDB" id="10443315at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="711"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="19"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="722"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="812"/>
            <end position="822"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW74221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="922" mass="95191" checksum="0FB805C5697EB114" modified="2019-01-16" version="1">MLTPQMFTPQVELPQVDLPSSPSSTSPGDSEPSKPPTSSPGDSEPSKPPTAPLSLRDRLNARVPLSTSRSDAPTLGSGVSVARRFNASEASGSGGPESWRARLKDRVPIKVPPIETSGEEAKSTASTSLKERLNSRGSISSSQGESPVESKSTSTVTTPLKGRLTSRTPLSTASSRTFALSESATSAPAPSSWRDRLQSRVPVTESPKPVVPGSESTSQDNDVSTISTTEVEPPSESKTNTESPMKVSTPSTPDSTPVPTSTISNGSPPRSSPAMTLRERLALRTQISANQATAVNVETPPVSAADGLSQAAIPTSSPVDKIPTTATSASISAIVASPLPTTANLPSDGLGYTPNGVVTESQSLAPEAMEAPPMVEEASPMIEGLQAVDVASIDDDSSRSSVSEISSMTDASSFTDASSIARSSLTPDISPGDASPEMKPSSAEDVLVAEVSIVETAPSIDSPPVTEARTTPILPISNNLVAAEPLSVAKTETSPVIESSSAVETPPAIDSLPTIEVPTVESLPGTKPSALADTFSIVETAPVIEPPRPMESSPVIKIVPGVPVSTTPHLATEVPLTVATVSPVQVLPTDNSVARGESPLIVESLLPTEASSTTDSSLDADAFLIKDVTPRISIPQFSNIAPASGAAPTNASSPAVANKPMMSFLKVPTSLGPPESGLFSGFFKSKPAKAETPVNFGTETLEQVAIPVDSSTVPKPLLGRSPTVSIPTSQEVRSSRPVVQSSTPNTAEPSNRVSTISNTSDMSDTSASKPNESPISGTVGTTIFSRFWGQPKPKLPSTETGSTKPPIVNTTPEPPPAALPAAPPATAIESSGILGGVASRFLLSRLTAQSTPPPPTEDIEDIKAREEIAKLNMEMMAAQNAAAKVNPLKGFGVKKITEDPEDIKAREEIARLTAEMLAAEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RP29</accession>
    <name>A0A3D8RP29_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Bacteriorhodopsin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_06529</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal/bacterial/fungal opsin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RP29"/>
    <dbReference type="OrthoDB" id="536545at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005216">
        <property type="term" value="F:monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007602">
        <property type="term" value="P:phototransduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15239">
        <property type="entry name" value="7tm_YRO2_fungal-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1070.10:FF:000160">
        <property type="entry name" value="Related to Opsin-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1070.10">
        <property type="entry name" value="Rhodopsin 7-helix transmembrane proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001425">
        <property type="entry name" value="Arc/bac/fun_rhodopsins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018229">
        <property type="entry name" value="Rhodopsin_retinal_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043476">
        <property type="entry name" value="Yro2-like_7TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28286:SF1">
        <property type="entry name" value="30 KDA HEAT SHOCK PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01036">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00251">
        <property type="entry name" value="BACTRLOPSIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01021">
        <property type="entry name" value="Bac_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81321">
        <property type="entry name" value="Family A G protein-coupled receptor-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00950">
        <property type="entry name" value="BACTERIAL_OPSIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0157">Chromophore</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0681">Retinal protein</keyword>
    <keyword evidence="4" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="5 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="29"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="57"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="229"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW75708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="301" mass="33299" checksum="674DDF06C2832FE8" modified="2019-01-16" version="1">MTNNALNVNHDVSNGKSSDINITTHGSDVYWAVCALMTFTTLGIVGSMFKKPRTDRIFHYITASITLVASVAYFSMGSNLGWTPIDVEFVRSNPVVAGINREIFYVRYIDWFITTPLLITDLLLTAGLPWPTILWTILLDWVMIVTGLVGALVRTRYKWGFFTFGCVAMFAVFWNIAWVGRKHARALGGDVYKVYMTCGVITLTIWMLYPIAWGVCEGGNLISPDSEAVFYGILDAIAKPVFGVALIAGHWNIAPARLGLHLRDYDEPISSSRHIDEKKEHLHGHAHGATAGATQTTNPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RQ34</accession>
    <name>A0A3D8RQ34_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15 20">Inosine-5'-monophosphate dehydrogenase</fullName>
            <shortName evidence="15">IMP dehydrogenase</shortName>
            <shortName evidence="15">IMPD</shortName>
            <shortName evidence="15">IMPDH</shortName>
            <ecNumber evidence="15 20">1.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">BP5796_06901</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22 23">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Part of the gene cluster that mediates the biosynthesis of mycophenolic acid (MPA), the first isolated antibiotic natural product in the world. Does not play a role in the biosynthesis of MPA, but is involved in self resistance to MPA, since MPA acts as an inhibitor of IMP dehydrogenases.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 15 20">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 15">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="15">Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.</text>
    </comment>
    <comment type="pathway">
        <text evidence="15 20">Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="14">Homotetramer. Seems to be able to form heterotetramers composed from more than 1 of the 3 IMPDH gene products (IMD2-4).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 15">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15 19">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="15 20"/>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RQ34"/>
    <dbReference type="OrthoDB" id="416622at2759"/>
    <dbReference type="UniPathway" id="UPA00601">
        <property type="reaction ID" value="UER00295"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04601">
        <property type="entry name" value="CBS_pair_IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000007">
        <property type="entry name" value="Chromosome 19 SCAF14664, whole genome shotgun sequence"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01964">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01302">
        <property type="entry name" value="IMP_dehydrog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF111">
        <property type="entry name" value="INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00571">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00116">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 18" id="KW-0129">CBS domain</keyword>
    <keyword evidence="4 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 15 20" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="5 15 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 15 16" id="KW-0520">NAD</keyword>
    <keyword evidence="9 15 19" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8 15 17" id="KW-0630">Potassium</keyword>
    <keyword evidence="7 15 20" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBS" evidence="21">
        <location>
            <begin position="138"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="21">
        <location>
            <begin position="201"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="15">
        <location>
            <position position="352"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="15">
        <location>
            <position position="465"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15 16">
        <location>
            <begin position="295"/>
            <end position="297"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 16">
        <location>
            <begin position="345"/>
            <end position="347"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15 17">
        <location>
            <position position="347"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15 17">
        <location>
            <position position="349"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="350"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="15 17">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="385"/>
            <end position="387"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="408"/>
            <end position="409"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="433"/>
            <end position="437"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="532"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00062187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="RuleBase" id="RU003927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU003928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="RDW76080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="550" mass="58503" checksum="9314DF3CC3A481C9" modified="2019-01-16" version="1">MPHTNGASTGTSAFFGASKDILDHTKALETLKQYEDHDGLSVEDLLDSKKHGGLTYNDFLVLPGYIGFPASDVDLESPVTKRIALKTPFVSSPMDTVTEHEMAIQMALQGGLGVIHHNCSADEQAEMVQKVKRFENGFILDPVVLERNTTVGEVKALKEKWGFGGFPVTENGKLGSKLIGIVTNRDIQFEYDDESPVSSVMVTDLVTAPHGVDLKEANDILAKSKKGKLPIVDKSGNLVSMISRSDLIKHQHFPLASKLPDSKQLICAAAIGTRPEDKTRLQKLVDAGLDIVILDSSQGNSMYQIEMIKYIKEKYPGLDVIGGNVVTREQAASLIAAGVDGLRIGMGSGSACITQEVMAVGRPQAAAVYNVSSFAAKFGVPCMADGGIQNVGHIVKGLALGATTIMMGGLLAGTTESPGTSFVNREGKLVKAYRGMGSIDAMQDKKAGAGGSKKDSQKSNAGTARYFSEGDSVLVAQGVAGAVAHRGSVTKFVPYLAAGLQHSLQDCGRKSLHELHQSVANGTTRFELRTASAQLEGGVNMESYEKKLYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RQK3</accession>
    <name>A0A3D8RQK3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Alpha/beta hydrolase fold-3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_06912</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RQK3"/>
    <dbReference type="OrthoDB" id="433474at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF33">
        <property type="entry name" value="KYNURENINE FORMAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="74"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW76091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="300" mass="33063" checksum="CBF08CEF70951437" modified="2019-01-16" version="1">MDEVEACIAKHGNVWSLATNNDMERLFEPLHEARASSYKTKVKVGKRFKYGSSDRHRIDLYTPITTPDAKLPVVIFFHGGGFVAGDNDITPSMHGHIGNYFASNNTICALVTYRVIPEAVYPSGAQDVTAALAWLRDNISQHGGDPSHLTAIGQSAGAAHLAAAIFSSRLSDAGITLHGAILLSAPLWYDLRQERRRKNMFAYHEASTNEEVLSKTGVAQFIDSNASDLPHTNILLVLGEFDPNEIVDGNLMFVDAYRKRFSRLPILEVLKGQNHISYFLGLGLDGDRLGKRILEFVALQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RV06</accession>
    <name>A0A3D8RV06_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNase H type-1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_05749</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW77897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RV06"/>
    <dbReference type="OrthoDB" id="3548481at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW77897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="29988" checksum="95DD659299E259A1" modified="2019-01-16" version="1">MGANSSVPEVKSTPSIDSHSHDSALLTDRQKRRRSEKAFVERGFEGNITINPNPCEATRHAHLEHLNPSHWGDKKSRIVFWAKGCCSGVGIVSQSSPYPEQWVWRAYRVMDEVDIQMAEILAVAMALKIAKDECDKLTLAGTERPSKVVVYSSSIDALLRIRESNFPNLSGVRMAKAGIRVIKANLVAAYFVRTLGIEVELRWIPDGCEIDRALESNRAASEGAKYKPPPTGPDAFIKDIQAVYERKEKANLWKKKAKQRKQSIRTTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RV55</accession>
    <name>A0A3D8RV55_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_05799</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW77947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RV55"/>
    <dbReference type="OrthoDB" id="431202at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022127">
        <property type="entry name" value="STIMATE/YPL162C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31735:SF1">
        <property type="entry name" value="VACUOLAR MEMBRANE PROTEIN YPL162C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12400">
        <property type="entry name" value="STIMATE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="74"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="210"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="282"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="282"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="351"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW77947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="400" mass="44000" checksum="48440B2BA5331DFE" modified="2019-01-16" version="1">MLPPPGLAPSSVENALPTILSTISSAVATASLDMPSATQTFAVIAATATALTDLHNTGHHDQPGPPPQEGECKLLGPFAILVQGALGSCALLALVYKRWRERPQRPLKIWTFDVSKQVVGSILVHMANLLMSMMSSGQFDLKGEYSPNPCSFYLLNLAIDTTIGIPILIVLLRIFTGLFSMTSFGEPRESIESGHYGTPPRVWWWFKQCIIYFLGLMGMKLCVLIIFLVLPWISRVGDWALGWTEGNEVLQVLFVMLVFPVIMNATQYYIIDSFIKNQSPNEHEILPHGDGEDHDSFNDTHHPYEDPRSGSSEEINSGDEDESASLSEDKTQPQDAPKKRTKRPFSSGSGRAKELRTGSRDYDPIYDGESSPTVVGSASSPRKLVSTDDSEDEQDVVAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RV96</accession>
    <name>A0A3D8RV96_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S8/S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_05851</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW77999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RV96"/>
    <dbReference type="OrthoDB" id="5386278at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07491">
        <property type="entry name" value="Peptidases_S8_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050131">
        <property type="entry name" value="Peptidase_S8_subtilisin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806:SF11">
        <property type="entry name" value="CEREVISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43806">
        <property type="entry name" value="PEPTIDASE S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0720">Serine protease</keyword>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="183"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="564"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="240"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="259"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="309"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="319"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="570"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="610"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW77999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="871" mass="97947" checksum="BF67032F8C59FDD4" modified="2019-01-16" version="1">MSDSHSRIHRESEDEDEFEASGEEEVLVKKAFDEILDKVKCDELQWDQRTDDLDQFEGKYRTFLNEKGDRNRTLLHELAYRAKKPNNSLKWLVQYLIIKYPLLMLSEDADEKIPLYVAICERKSTLVRSMIDKYPDLSSVFERECNRSDYCLHAAIRNGLPSKTTIELIKKATEKSLIAEDVKGFTPLHLAVDYERCTSSQYDIVKALIEQGDSALDRVTKAPDCYSPYRWHIYTREKAERHQTNARKVNVRATAETKAIGEPELKELNPAKESRSNEDRRIRGGNNSNILSPQVSNATTRDSLMPRSAPSSRNLSRARQNEDPKDKEASAEKIKQEMKVHYLRTRGTKGALDGLYGTNKDDIQICFDYFGGPSEVDPHKFSLSFEHIRLDETLAYVAFPQVKWLRDKGVRRILKVVIDDMQEPAHSDEAIEEALKGFGVEILDWQKPDICPETICKDLETSHRLDHNVEQFRDRLRASLPTDLPNANPRDISLSVVEEGGGERLLTGNAAAPTLTGKQDQGISPHRWLDCMDKFADTIQNVWTSVSKSESVREGLPNLLQEPVEIALIDDGVDNSHPTLLGKISGGKSHDFSYEKDGMIKPYWVSAGGHGTVMARMISRVCPIASLYVIRVETHNSKDSKQHINGPSAVLAIETAVERKVQLICMSWTIKQPEDPAEKRRFDNAMEKAFSQNILIFCAAGDVGAHEDSDYPAAYNPNKVFRIGAAQADGNAWSWAGHLNSLDFIIPGHEVIERESRDIMLQNFKPHTGSSVANALGTGLAALIISCVKLGAIHTHLKGASATSVGINHLGSLQKHAKMKAAFKNIGTSEESLGKFIEVWRRFDQTETNLKGRDKDRQLDSIAKLARDLCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVA7</accession>
    <name>A0A3D8RVA7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nephrocystin 3-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_05849</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW77997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02249">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="8">
        <location>
            <begin position="303"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="899"/>
            <end position="931"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="1097"/>
            <end position="1129"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="1198"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="1299"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="1336"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="6">
        <location>
            <begin position="1472"/>
            <end position="1494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1657"/>
            <end position="1679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW77997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1679" mass="188264" checksum="BCADAB78BF927757" modified="2019-01-16" version="1">MESFTTGLIVDADESEDSPVYDIVIVHGIGDDPKEVWLDSTGPGNWLRGKMFALRCVRIMRYGDDTRGSMAGINTLEDIKEVASRLLESLLKLRMEEIQGNERPLIFVTHDIGGIIVKQALVLAGLNYARFGSISLSTVALIFFGCPHRSINNQDMEDNIARLLLVSGCVQRHGFVSVVKRLAQSIIDINNDFLDTKMLIRPCIFNIFSTVQDPHHFVFDESTATMCIPFENRLRSGRRHMSLVNDPESDIYIKSVLQVLENSSYPLNLNIDILTILPILLSQSSPVFPLKSRTYPASGSDYINQNENFRKWMIGTDWGILHAHGTSGVSQASDLIYQQLEASRDTKDGKFSNRAVLFFKFNRHDTRFNTLQAMLSTFLAQIVTHFREVGPEFILDFQRLSLCHAWSSKDLYSVFENMCLRMENTSLICMISCLDECLEASDWLLEQLKYVFRSSECHYKVIITSTNSVEIKHSLSDFPAFDIVGYVASNGNNAPTDTPSIIELELRYLLQEKPIFYELSTRIKDLLIECDSDSQLRCLIVNWLVQSKDLTPKMLNDRYLEEMSPATPQNVLKAFLNSTSLDKRLQLRNAISWVLYAFRPLTCSELQVALAPTAHHEVSEATSQRFMADFREQFGSMLVVEHNEIYFGHPFAREFFTTTESPENQAWYNLSNEEIAHGNMARSCLLYLSSPNVQSKIESFCEMNSISRQSPIFCSRSNLLSYATQYWSSHYRKAKLTDTAQPFQHTKALRNWAQAYHCMSNPVTRSTTSPRPPLSIYSSLGLKTLVASDISTQSETVFFKKNCSSALIESARNGHIETTRLLLETLKPNAATLRDAVTASAACGEELSLLEIIKHICFSTEKFKWPQDILHRAAWLGLEKVTTRLVAVGLDVNSVSQIDGMSPLHLAVRNKHIQIVCILLEGGAKLQPGDKNMPGVLHTACLYGYPDIEKLLSHANADLENGCVTKWTPLEVASYYGQCKALEAILSTPASSRFQEKVLEALALAASRGHVHVSSMLLQERMVLKSTYQAWSKILQSGVTTGNVQLVELLLGHEDSQSEDTRLKSKNFALSLATELGFKDIVARLLDQGANPNESTLKPSPLYLAADNNYLDVVELLLAKGADVHFSTPYGWRPLHAAHNSPEIARALLNSGADVNCISNSGTILYLAARYNHPGVVKICLQYNPNLEVEFVEEGHFDGMTALTVAADCGNTEIMRLLLDAGANINHMTRRNNFPLQFFLIRNVPTEEGLRTLLEYNPNLELQDDDHDVALNCLTPTTPVSLVKLLVHAGAKLEIANHLGYTPLCTAIVQGNNEVVKFLLSKKAEVNNIRGYRGGPLHLACRNGSLELVKLLLDHGADINLADEGLTGTPLQSACLVMFQKQSAANIEVINYLVERPDININLYAGTLGYAISVACFDCSTDTVKHLISKGAITDVKDNLGRRPLHFASMRTLDHIKLLNPSVEDFAATDITGRTPLHYAAVSGQVDLVKYILDTSNCNVDERDFDQWTPLLWAARKSKEPGWTEAGQAEVINLLLSRGADLWARGNGIHGHWSPLKIARYHAVQDTVLGFLKPTEEQRLNHKGEPWDERFHLSEKREPVLRLCDFCLLKMWGTYYRCFTCLNFDLCFKCYGWKNTLHYGHDFEELEAEAATNPYTSIAPRGHRSKSLQDDITDSEDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RW18</accession>
    <name>A0A3D8RW18_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 6">DNA replication complex GINS protein SLD5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_05853</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">The GINS complex plays an essential role in the initiation of DNA replication.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GINS4/SLD5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RW18"/>
    <dbReference type="OrthoDB" id="338231at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11711">
        <property type="entry name" value="GINS_A_Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008591">
        <property type="entry name" value="GINS_Sld5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031633">
        <property type="entry name" value="SLD5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038749">
        <property type="entry name" value="Sld5_GINS_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206">
        <property type="entry name" value="SLD5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16922">
        <property type="entry name" value="SLD5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007764">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="7">
        <location>
            <begin position="80"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="DNA replication complex GINS protein SLD5 C-terminal" evidence="8">
        <location>
            <begin position="178"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR007764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW78001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="233" mass="25660" checksum="4E0E3F1D481EAD79" modified="2019-01-16" version="1">MDISDILDSVTSTSNRADPFSSSPTSTPSGQALLQSLTRAYINERSSPSLLPWPANNLIPHISALIKSQIDAVELLTGDMDPRSNFALIIIQTELERWKFLLRGLLRARLSKIDRFAAFYLSEAESEEGRMSEDERAYALRHQALLKAHYDASFLGAFPANLRGLSDTAGGISMIEGPDAEKGVFARAIQDEVMFEAMGRESDGLVEMKRGEVVVARWKDVEEGVGNGELELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RW83</accession>
    <name>A0A3D8RW83_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_06194</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RW83"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF170">
        <property type="entry name" value="AMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="1">
        <location>
            <begin position="86"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW78342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="560" mass="60718" checksum="66A127767C8B1F0A" modified="2019-01-16" version="1">MSASITTEDVHKQASKMGVTMKPAEVEDYQKLLSEANTVFERLMSMPDYHLPVDTERFPRQNVKQPTADENKLGVAWAHTFSVGGAEKNPSGLLAGKTFCLKDNICVAGVPQVNGSDMIEPWIPKADATVVTRILEAGGEIIGTATCENMSYSLMSHTSSTGIIHNPYREGYSAGGSSSGVGALVGSPENYVDMGVGADQGGSIRIPSAMSGCVGLKATHGLIPYTGVVTSEAIMDHVGPICKNVMDVAVLLEVLAGRDGVDDRGVGAQRHGEIPYSSNLQTWFDNSLQPTAGLNKVLSGMKIALIKESYETPLMFPSMREKFLSSAYRLRELGAEVTEISMPAHDTARDVWMGIRRLGGSLSLTGKASGRRQYCLTPFLERMLPMTQEKWEKTHANLKSTIINGSFALEKYPTLYAKCLNMQIQLSREYESLLSQYTLLLTPSLCRTAPKLLPRSLPVYEKAQSEGGISINTSQFDLTGHPALTLPIGLMPDMGGDDETVKLPVGMQLIGPLHGEEKILKVAYAYEKNWDWKSEVGQLANAEQKEIPPGVQDPMTTAGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RW85</accession>
    <name>A0A3D8RW85_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_06191</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RW85"/>
    <dbReference type="OrthoDB" id="5207413at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW78339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="275" mass="30861" checksum="F9A9E69A4F3EFBCE" modified="2019-01-16" version="1">MANWPAQSQYPPRTSSRRVSPPGVYVNVEFGIAFSQHDRVHTTSMKYASKNMEHRFREQQARAAVPDMLRSGYPLSAREARAQPQLPQHPQSSRAPRLVIRRRDQERGTSAPPSLQERHVDNSTNSIDGTRVSSSQDRRDQPLPPLPSEFRLGEPDMPWSAPQFLPVATYEDPTTLDMDFQSESTRGEDPQRVRDLGQLQQAMMTVDSLEENELDALTSEGIGGLPRGPRSLGWAISTNDAPETPKSPAPPPYVVSQWEERYGGYFRPGRPRSSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWV1</accession>
    <name>A0A3D8RWV1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MARVEL domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_06166</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWV1"/>
    <dbReference type="OrthoDB" id="3930290at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW78314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="182" mass="20599" checksum="6C3F1127B7066F35" modified="2019-01-16" version="1">MASTESTMTEIVVQRVRTKYHWPAIQLNFWILIMLVASATILGIFASFISVQTQLQLGIPWYFPYWVTVGSIGIVFVLIMLYLIAQRQLLPGIVILGSFILFVLFLVGLIVTSIELWGPVGNVDSNCNLLQSSTGPNEATLAWLEQHSICQSWQAAWAFQLVGTIFLFWMMVMAYQVYRQDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2W6</accession>
    <name>A0A3D8S2W6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-glucose 6-dehydrogenase</fullName>
            <ecNumber evidence="3">1.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_05139</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>UDP-alpha-D-glucose + 2 NAD(+) + H2O = UDP-alpha-D-glucuronate + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2W6"/>
    <dbReference type="OrthoDB" id="5059218at2759"/>
    <dbReference type="UniPathway" id="UPA00038">
        <property type="reaction ID" value="UER00491"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003979">
        <property type="term" value="F:UDP-glucose 6-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006024">
        <property type="term" value="P:glycosaminoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000271">
        <property type="term" value="P:polysaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006065">
        <property type="term" value="P:UDP-glucuronate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.100:FF:000001">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000193">
        <property type="entry name" value="UDP-glucose 6-dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.100">
        <property type="entry name" value="Cytochrome c1, transmembrane anchor, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017476">
        <property type="entry name" value="UDP-Glc/GDP-Man"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014027">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036220">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014026">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001732">
        <property type="entry name" value="UDP-Glc/GDP-Man_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028357">
        <property type="entry name" value="UDPglc_DH_bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028356">
        <property type="entry name" value="UDPglc_DH_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03026">
        <property type="entry name" value="NDP-sugDHase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374:SF3">
        <property type="entry name" value="UDP-GLUCOSE 6-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374">
        <property type="entry name" value="UDP-GLUCOSE DEHYDROGENASE/UDP-MANNAC DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03720">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500134">
        <property type="entry name" value="UDPglc_DH_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000124">
        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="UDP-glucose/GDP-mannose dehydrogenase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="477"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="421"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="365"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="410"/>
            <end position="414"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="418"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="424"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="484"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="491"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW80441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="706" mass="76718" checksum="0058A11CCE95A86F" modified="2019-01-16" version="1">MDKRLMKVRQPILLKPFTAGKRVLTTFAAMFGIPRQQPSTVVSDDVMDNSTAPTTPEGSLTFSPVLQALKLQDALEDAVSQKDDLRAGSMSLNATLYTASPQVKKICCVGAGYVGGPTAAVMAFSNPSIQVTVVDRDPNRIQQWKTKHLPIYEPGLTEVVRIARDGTRACAFRNESSKAELDNMSSTTSASSECNSQCGEHLAEELFIGARPPNLFFSTEVSKTISEADIILIAVNTPTKSRGIGAGRATDVGALEAVTREVAIHAKRGAIVVEKSTVPCRTAELIQDTLNVNRPGLHFEVLSNPEFLAAGTAVNDLLNPDRVLIGSSRTPSGRQAAELLASVYAAWVPRSRIITTNVWSSELSKLVANSMLAQRVSSINSISAICEKTGADINEVAYSIGLDPRIGSQFLKAGLGFGGSCFKKDVLSLVYLAESLGLEEVAEYWQQVLKINDFQRTRFVRRVVKCLNGTLVGKKLAVLGYAFKKNTDDTRESPALEMIKALLEDGPAEIAVFDPCCEPAVIKAEIKRLIDRDEPVLKEDGGPVEVYAEPYAACADTHAILIATECDEFRNNTPLKTSGNSALRPMLADPRPFPMLEPPEASLLALHKYLVSSGPTISRDPLQRYQAQPECEVCCAQCASEEIKRDVRKGGKGNGVRGEQLDWQRICYGMRKPKWIFDGRNVVDADAMKELGVRVESIGRVGWAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3J1</accession>
    <name>A0A3D8S3J1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">26S proteasome regulatory subunit RPN1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_05359</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the proteasome subunit S2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3J1"/>
    <dbReference type="OrthoDB" id="10252509at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000026">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016643">
        <property type="entry name" value="26S_Psome_Rpn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041433">
        <property type="entry name" value="RPN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040892">
        <property type="entry name" value="RPN1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18051">
        <property type="entry name" value="RPN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17781">
        <property type="entry name" value="RPN1_RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015965">
        <property type="entry name" value="26S_Psome_Rpn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RPN1 N-terminal" evidence="8">
        <location>
            <begin position="65"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit RPN1 C-terminal" evidence="9">
        <location>
            <begin position="850"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00057191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR015965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW80661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="908" mass="100627" checksum="F349A66152CA6A7F" modified="2019-01-16" version="1">MAQDGEVPKSVDKGKGKAVDAESSKTGDVQKDKDGKPVVNGKGKEEPVLGVEELSEEDQQLKSELEMLVERLTELDTKLYKSALEAIKDSIKTSTSSMTAVPKPLKFLRPHYEPMIKLYEEWPAGEDKTSLADVLSVIGMTFSDEERQDTLKYRLLAPTSDIGSWGHEYTRHLALELGEVYTKRLTAEEPYQDLIDLALVLVPLFLKSNAEADAVDLMSELEIIEDIPKFLDKDTFPRVCLYMVSMVNLLTYPEDQQFLRTAHDIYKKYDQLTQAIVLAIRLNDVDLIKSDFESTKDVALKKQMAFLIARQQIVLDLPTESDEDQEIAECLNNTKLPEHFKALAKELNILDPKTTEDIYKSHLESNRVAGLTNLDSARHNLAAGFVNAFVNAGFGSDKMMMVEEEKSSWVWKTKDEGMMSTTASLGTLMLWDVENGLDKIDKYTYAPEDQIQAGALLAIGIMNSGVRIDSDPALALLGDTDKLLHKNPLVRVAAIMGLGLSYAGSNRTEVLDILLPLVGDTSLDMQISAMAALSLGMVFVGSSNSDISEAIVQTFLDDDRKSQLKDKWTRFMALGLGLLFFGRQEEVDVILETLKAIDHPMSKPTSVLAEICAWAGTGTVLKLQELLHICNDHIEETDDKKGDELLQAYAVIGLGLVAMGEEVGQEMVLRQFAHLMHYGEANIRKAVPLAMGLLSPSNPQMKVYDTLSRYSHDNDNDVAINAIFAMGLLGAGTNNARLAQLLRQLASYYHRDQDSLFMVRIAQGLLHMGKGTLSINPFHTDRQVLSRVSAAGLLSVLVAMIDAKQFVTSNSHYLLYYLVTAMHPRFLVTLDEDLNPLTVNVRVGQAVDVVGQAGRPKTITGWQTQSTPVLLAYGERAELEDEQYISLSSNLEGLVILRKNPDWDGGKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3P1</accession>
    <name>A0A3D8S3P1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_05574</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="10333807at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="185"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="422"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="625"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="791"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="833"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1250"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="759"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1253"/>
            <end position="1263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW80876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1310" mass="143837" checksum="F14A27F8931B4BEC" modified="2019-01-16" version="1">MDGDEPLDNSDLNAFFNDNDMDPDSLEGGFGEVPTDQDLDFWFPIATQEQGPEVENHPAGDNSLYQYGAPSEEQNTFGPFGAQYATAPVPAGSMPNQPPTPAAGPEIATLGDFSAPNANDPPIITPGIFTASQTCVACANSNYPCSISITGVPCFWCRSYGVFCDVTQLLNGQLQLGVGMYEQQVGGTGQDQSAPAGTPSVPAGAPSVPAGDPAEETATAGLDEKPSQWSDSQYRPKGFGPFVRRRNPAQQAAQKLAISADTVVGALGNVIQTRAPTNAELAYPEPGVFHAGLGGYVDDGPRRPQESSRSSKLRRQMAIENMGIRAHPNLEEMWQVRRDQEAGNRDPNLTYVAWNQNILKRYREIQDRALLLVKKLNPRHSGYDPAFARDWNASEQARRMENGYRRTAALIYTREFLANARRGTNIPDPEPYESDDELNQTGIWTKKSDRRSRTESGDDGKGGDDADDNPAALLPGEVPPNTPFLRQRCRPCFGSSKGCDVGVIGRPCARCKNKPLSCVLADPIRPRRNPLPNSTIRRIIKVPTFSQQPDAVDRIRAVGGTGVNPDTYLRIDAPQNSRAMVPMPARSFQYNHQIDIDDDDDFPMGDDSGQVGMHLPPSATNRNPYIASPSSPQPAITRRVSRSATTKAPVRPVQDYDGRPAQMGESAAGSSRGVTTRTQAILESNRPARYGPAQTFVATAPAPNTSSSVTRSGTSRDEAPSLLASGSGRGNRTRPGRRRSSRAGSAIPSTGAAAGSRQTPTTVAAAWPAPGSGPVTRSRLFSQRIRTMAADVNLDDESSSSSSEEGQDAAPIRVSKRPMPSWVKSRNAINARRAREAREGMPQVDKSTLHRDWKPSQQGDRCWTCWRKQRQCTGPREESNDLWPVCEECFDEDEAENCMWGDPNSYNDYVANVDDENPTRAPEYAYRRRYLARQRFVDQTLAGVQTARTSQSWYVGAGAFYTNPGHIAQRDADAITQAINAGGIYNPYNHDNPNINQPTPAGGPLPGIPTALDLQQDIVEWLRRKDPRIRPFRAEDQDQICRERRRLVPNLGWETVMTEAHWNRVVFGMEHRYWSEHHVGNSCRCDVVPHNRGRRNFASCGHCRDRQVTFHNQKQSVLLVDIKQWFCEQCAQDAKREYISNHVHFKVDNCTCTGQMTVPWLCNLDRDAAMTEVSKRARLMNRYFVLQLQNRAACGHSRAPINTTPSECRSGQDGASTSGVWACKSCRDIVIKSTANYASDDVLRAAQDQLQAGGSGDGDGAGGLARPAYDPKDHIPAGMEGADEVLMTRLAAQVFLIDSARFVSWRGNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3Y4</accession>
    <name>A0A3D8S3Y4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">alpha-amylase</fullName>
            <ecNumber evidence="4">3.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BP5796_05673</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endohydrolysis of (1-&gt;4)-alpha-D-glucosidic linkages in polysaccharides containing three or more (1-&gt;4)-alpha-linked D-glucose units.</text>
            <dbReference type="EC" id="3.2.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.1" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3Y4"/>
    <dbReference type="OrthoDB" id="204980at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004556">
        <property type="term" value="F:alpha-amylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11319">
        <property type="entry name" value="AmyAc_euk_AmyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.80:FF:000120">
        <property type="entry name" value="Alpha-amylase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013777">
        <property type="entry name" value="A-amylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015340">
        <property type="entry name" value="A_amylase_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF215">
        <property type="entry name" value="ALPHA-AMYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09260">
        <property type="entry name" value="A_amylase_dom_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001024">
        <property type="entry name" value="Alph-amyl_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0106">Calcium</keyword>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="9 15" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="18">
        <location>
            <begin position="16"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="13">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="13">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="128"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="248"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="311"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="14">
        <location>
            <position position="311"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="254"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="15">
        <location>
            <begin position="454"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR001024-5"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RDW80975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="521" mass="57131" checksum="F5AA2D6130679A5A" modified="2019-01-16" version="1">MRSTLSLPSSSGVSGAAMPRRRRTGAAGPSIKSSPIASPGRMARQRPRALRATRGSAVARGRDMGFTAIWISPVVQQVSDQTRAYTGYAATNIYALNSNFGTASDLTDLATALHDRGMYLMVDVVANHMGYDGTAETVDYSNLNPFNNQDHFHNLCWIDNYNNQTNLEDACLYPPSRCWLGSDHYPLPDLDTTSTTVRDLFSNWVTELVSNYSVDGLRVDTVKNVEREFWSIFNTASGIYNLGEVSNGNVDYFCPYQDHLDGLIDYPTFYQATQFFANTSATSTNFVNEVQALVGTCNDTTLLGTFSENHDQPRFASYTSDMTLAKNIITYTMLADGIPIIYQGQEQHFSGGTDPYNREALWLSKYPTHSELYQTIKNLNLIRAVATNQSSTFLTSTTTTVYSNDNTIVFGKGESDHMVLTVVSNLGRHAKEATITVPAAGLPKNIQMTDVVNCHSVDVDDNGGLEIKIKQGQPMVFYPRSLMESTDLCKGKKSAATPTYGPSAVSLGLAFIVSLLLVGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SA37</accession>
    <name>A0A3D8SA37_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Leucine rich repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_04723</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SA37"/>
    <dbReference type="OrthoDB" id="676979at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.10.10:FF:000273">
        <property type="entry name" value="Leucine Rich Repeat domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454">
        <property type="entry name" value="NISCHARIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15454:SF69">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 11-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13516">
        <property type="entry name" value="LRR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="32"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="290"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="632"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="754"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="803"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="35"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="337"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="368"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="385"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="396"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="662"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="822"/>
            <end position="841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW83232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="856" mass="93235" checksum="C23567F879187A88" modified="2019-01-16" version="1">MDTEDGQFFIKNLAHFVRTHEKALANALQLRRQKNPNNGSQNSGTVGATAVPTSPTITNTPSSASSATTSSTLAAALSLPYLSFASHNLKPAKLALTPHHLFYLLSRFEDLSIPVGPMNVRIENLHETSATNYVSFLSQSQRPKGRGSDHGSIHSVSSVRSVMSGMSSLWANFGLGGGSSAAKTEKQKAAIEADLKYLYSAFTKIPCLRLAPDRRARLIEGYEEFPFDTAVPLIAFKNLSALEISDIDIRQFFGWDRLAEQLRSLTVKRAGVDDPADLLIHIVLDDMDKRRRRSSKAQMSPTTTWVASSSPRRSPTLPHAELVKASSDPGSPGSPEPRTHSDDDESRRSSLARSGSDGAKSPSKGRPRSNSPVRPPSSRTGSSHGHFRGSYKVKRSGSGSSQSSLSDGWNNGRGSSSNLLSMGILPSSKWRFLKHLSLADNGLTSVSATSLAPLANTLHSLDLSSNLFVQIPDSLASLTALRALNLSNCMIDSLHSLTKNPLPAITALNLRSNRLISIAGIERLYPLERLDLRDNRITDPTEFARLTGLPDIREIWVTGNPFTKTHSNYRVTIFNLFRKTPGYTEDIIVDTYGPGYSERRNLVDRAAERPNVPVVKPPPPDYGLPAVDVNKPIIEQAPRDPNLLRKERPVPMAATSEIHRSSSGRRRRTPKRRIVDLSSTDTSPNKPKPGVRFSTEESAVAVAAAAASDSGYGVSPDPSPRTVPLYVHSERQTQSTPDFPRIDTSVVPRLKPIETVSAYDPPSSKPLTKDPQDWNISGEIYRKKIEALRSEVGNGWLSVLSEENWDPQKTGNGQGYPTPDFSPASTARPSPSTPRATSQQTIHSGRTLGGQISAHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SA76</accession>
    <name>A0A3D8SA76_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative nitrogen metabolic regulation protein nmr</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_04505</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SA76"/>
    <dbReference type="OrthoDB" id="5356836at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF5">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="63"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="403"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="403"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="439"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW83014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="448" mass="49302" checksum="9E304B5683DCA88D" modified="2019-01-16" version="1">MPSATPRSIAIRPREEQTSRKLKHAPSTSYPTESYLNAAVQFPIITTHHAPDRPTKRPMPTPNKTIAVVNSSGRQAASFIRVASAVGFKVRAQLRNLDGIVATEISELPNVQVIVGDLYTRGDSSNPPSPGNDKNSGVNHALIKRLFDGAQLAFINTTFYGDEVAIGKALADAAKEVGIEHYIYSSMPDHSTWNPAWPSLPLWSSKYAVEKYIRSIGLPSTFLYTGIYNNNFTSLPYPLFCMELQSDGSFLWTAPFHPDIKLPWLDAEHDVGAAVLQLIKDGISQWGSQRIALAYEMLTPREVCRAFARGIGRPVRYCHSPVIEVKVKIPAGYRDQLTALEQLYAIDKGDGSKQPPYFGHAKFEATCPEEALALWEGNRGMEEYAREVFPLEEAANGLTWMNEDDEPAQEEEQDTDGEGDSDDEGLTMGGGIGSGDATPARKEEGWLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAR6</accession>
    <name>A0A3D8SAR6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_04851</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LIMR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAR6"/>
    <dbReference type="OrthoDB" id="203099at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051584">
        <property type="entry name" value="GPCR-associated_LMBR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006876">
        <property type="entry name" value="LMBR1-like_membr_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21355">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR-ASSOCIATED PROTEIN LMBRD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21355:SF0">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR-ASSOCIATED PROTEIN LMBRD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04791">
        <property type="entry name" value="LMBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="361"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="452"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="503"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="564"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="648"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="202"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="571"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW83360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="692" mass="77637" checksum="1A35221327E85CA6" modified="2019-01-16" version="1">MIEIASTSSPVGSVVFACIAVFVLSIAVLLILRHYLPLRTTPAFLLVPIFFALWLPASIVLLVPIDLASSDSDHDVGNRGIWLPQRAILVSWRITYWLTFALTWFILPILSEYADAGYRDPKGRLMFSLRANAQYQALLFGSAFVGGIYIFITSGVSFESLKGTVMAMAYCWGLILAIYLMGHGLVAIPRSLFRNASVSGRLRRFQQKAAKVHEKMEEAITNMEDLEAQVTELSKRKTGSARLFEEWIEELVEESHLPESRPRTLARRMSVPNVTTPSVITERYMADLSRQLNRAQHSRARYVDEWDRLLYEAVATQAILDSAASKRIDIGQSSPHAGFWDQITIHTPYTRYLYHYYFMPYFRISSGAFLALASICIVWSEVIKTVNPFISVISLTVVHHPNSDRGQVGFAGQVIASLWILYMFAAALTSLSEIKVWRGRALVRRNTHGESAGWYAMQVAKLSVPLSFNFLTFLAPDVYMDTVFYKFLGKLINLTPLGSWFDWLFPMFILFPVCATLFNLYGKTKRLIGMDGVIDDDEDENQSGYGTGSWREGRDLIERELHGHSSLPRLSNGNGAASRSATGTSAPSSRLAPTLSVPPAERRQAATSSPRPSLDRQQRQAVAPEEENFLEAFGHRVKNTLDTVQTPRWLQNMGEGITRPKWMGGDGEGEPSRSDSSFTRLFGGRQDGRVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SB29</accession>
    <name>A0A3D8SB29_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_04805</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SB29"/>
    <dbReference type="OrthoDB" id="28755at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37490:SF1">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 2-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="116"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="224"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="247"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="330"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="402"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW83314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="762" mass="83976" checksum="FE05854C367BD2C9" modified="2019-01-16" version="1">MQEALNEEEGRRCLLLDQPRPEPVAQLPPKPSPSADLAHPQAEYDDNYDLEDLYDAEKDASKGPQESAREDWRRILFWIVTSVTAVLSSKLLMVNYDYHYRALALHYWNVHPTDFCLALTIALRSFVVLGLAYVLALYTADEPKAEENILWNYLQGSRRGTPWPVATWLAMFPAALMAAVSLPMFMMGVLHMPSLPVLVMLFPLAHATEALLSFITCSVIGARFWLPMSALAIIAALAVVLRDEYRLLVQGLIWGPVSIISMGLSRGFFRIASECIGLQWNTATRRGAFHGFAIMTIIFGTFSSGIMAYFYEPGPDPTVEHQALSASTLILMIINTAAVVCTAFTGTFLLAYSPLFYDSATVGFSSVPLPVSEFLASTFASQISYIIAIFAAPTVLVSWVQVAAYSVAIMCLGGPSSLYKSFGSFNSPQRRDISNPGSGYTKLREASRPRKVIMLAPLFLMISFWTYLLTSIAEAPIAMLANQAAPSLDLAYQPKTRIEIVLSMYDESPESVASLIRDIKSTTYISSFPKQEVKTTVYTKHPTDDLEMLKSLTKAGSVIRLANLGREGGTYLRHIVHNWDELAEQTLFIQAGPHNKREILPRIESYLGANTGMLSLGEAGAVCDCLTCSDRWGWSDSFHVIPGLYSRVHPGNELCTPETQITISLKGQFIASGRRIRGISKDIYREMLEAIESEVGWSHDPQIVGSKGDTADNPIFGFTVERLWGLLLQCADPQIGAKCPSLLSGTLGFRRGGGIEDCACLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SB79</accession>
    <name>A0A3D8SB79_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_04519</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SB79"/>
    <dbReference type="OrthoDB" id="10458910at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW83028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="130" mass="13985" checksum="BB68CE6332923CEA" modified="2019-01-16" version="1">MANQPEKRTHTLIQSPLTAFLSPPEEHYLLLERQAPDQIGTRTIGSPNTPSRPQPSPSSYIPMSSATFTSPPTKSPELTQINTSQKTGQASKTVVVGSVVSAAVGIVVLAGVGYGAWRWRRRVVDDEEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SBW2</accession>
    <name>A0A3D8SBW2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF3074 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_04739</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SBW2"/>
    <dbReference type="OrthoDB" id="5403181at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024500">
        <property type="entry name" value="DUF3074"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF14">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11274">
        <property type="entry name" value="DUF3074"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF3074" evidence="2">
        <location>
            <begin position="122"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="509"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="618"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="696"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="319"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="398"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="553"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW83248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="741" mass="80726" checksum="243090A146D2DB23" modified="2019-01-16" version="1">MAALHNALKSLGPTEYSDVPISSPEALTPYLSDAFSAGQLIVDSVPNAAPSGNSVTSEQRERASSTASNALEMEISDARSSPPPADVEALQKEWKPVKLNPRDNPLGISVYKLGGKDGKGAWFARKSVHEGLGFTKWKKSLEREFPETLKVQGAPGEGNIRGIGGERRVEYKSVEGVGNVEVYHLSAQFPGPTAPRDFVTLLITSDQALKPHSESEEGIPRHYMVISKPCLHPDALPRDGFIRGQYESVEFIREIPRAPPRKSMSASNLLQKHEDLGKEAILRNASKQHPEFSSQDDSGLSRSDSGRARGKTISFAESRGADAKGEDMDKRREADDENELNPIEWIMITRSDPGGSVPRFLIERGTPGGIVADASKFLNWACAIDLKDLESGGDTENALDKEPSILTKEEPQDFNANGHLAGLERSDERPSEPPSVANEAEPATTKDGGIYGMVAGAAGMAGEFIASNMTAKYLPGQFPDSSTTLNDGSASPLRRDSISTVASTSSIGSFTSALSHGPVSGNGVIDDTTSDKTATSDKTETDSVTRSRASSQQDKELQKLEDRKRKLDEKLSKARENELKKKSEDTQKEADAIKKAEERHERELAKLEIKKEREIAKLEAKRRKDEQKAEEKKRKALEKDEKTRLARELEEIRAEVLVLRKEKDLMRDQIGDLQAENTVLAAKLGRLGPQGEEVLKEARQDAGKGGRKRGASLRGLKRNGSTMSVSLGSLSSGEKEKQEAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SGW9</accession>
    <name>A0A3D8SGW9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_03922</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SGW9"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019819">
        <property type="entry name" value="Carboxylesterase_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00941">
        <property type="entry name" value="CARBOXYLESTERASE_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017495501" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="24"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="116"/>
            <end position="585"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW85597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="590" mass="63517" checksum="AB3E0DF5A6192A45" modified="2019-01-16" version="1">MTPTFVSVRSALTLVSIFGLTSASLLSELLDDLTGKRGVAAAVAASSSIGACASATPVTVTVTERVVVTSVSSSASSTTALATSTSVSASSTLATASATSGTVVLPYATYAAELNETYSFYKYSNIRFADPPTGNLRFKNPTAVSTVNTTIQDGSYGQTCYQLEQGSNSGAANQGEDCLFLDVVVPENIPAGTTLPVLFYIYGGGWHTGQKEIYDGSDLVVTSNNSVIYVIPNYRLGSFGFLGQFGDTNPGTMDQLFAMNWVQDYIHLFGGDPNRVTVAGHSAGAGCLVTHLVSNGGEGSVPFQQAVVMSPAVTQTFPEVIAARNLAMLEYFGYENYTQAEILALDAQAINDMTGHIGSSGWGPIIDGDYYREMPGLAFANGRYHSNLSLITGQLADEAHDFIPTISPYIIDSSSDIRNMTYDTEAQMETFFTEIGFTLNTSQIDEAWSLYPTINNTDLYYTMFGKYDKLASELMFDCYSYYMSNAYYVVYGWYFDVPPSYHAQENPYLFAGGTGTGGSSSYAINATLSTYMKTYLVSFTMGDINADSSIPTWEPYSIAQQNIELGDSNVGMIADPSNNDRCVFWETNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SH76</accession>
    <name>A0A3D8SH76_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DUF455-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_04030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SH76"/>
    <dbReference type="OrthoDB" id="360327at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF2">
        <property type="entry name" value="SPLICING FACTOR YJU2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="251"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="306"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW85705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="342" mass="38281" checksum="DD4352D08299CCD2" modified="2019-01-16" version="1">MGKYVPPDQEGVISGNKLAGKHALGSRAKKISQGILTVRFEMPYPIWCTSCPKPTIIGQGVRFNAEKKKIGNYYSTPIYSFRMKHVACGNWIEIQTDPKNTAYVVVEGARKRDLGEDKVNEGDVKILTTEEREALRNNAFATLEVKAEDKKRLEHSKLRLEELQDLSEQWEDPYERNKRLRRTFREGRKQREKEAGVTAALQDKMSLGLDILPENEDDVRRAGFIQFGDIDGEKAMVKAVSKPLFALMDKTPESTKSKSQPKSKKLTAEEAARKKTADAVAEIRGNTRAAMDPFLIGTKSITKPLLAGVKRKRNTTESTTLSKTEESAPASSEVGLVDYESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SH86</accession>
    <name>A0A3D8SH86_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03839</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SH86"/>
    <dbReference type="OrthoDB" id="2342176at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36182:SF1">
        <property type="entry name" value="PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G10930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017560061" evidence="1">
        <location>
            <begin position="19"/>
            <end position="411"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW85514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="411" mass="40653" checksum="4E967FB419A93B79" modified="2019-01-16" version="1">MFPTELLLTAILFGSTATAHIAPIWPYPFRASYNPNSVSAKIDYSITSPLSGASQFPCKGYQVDMGTTGGESVVSWAQGGAYNFTTGSGALHGGGSCQIALSYDKGVTFNVIHSYIGSCPISADESFDFTMPSDAPTGAAMFAWTWYNMIGNREIYMDCASVTITAASSKTRSASSVAFSDRPTLWVGNLDNGCTTIESTEVVFPNPGPDVTNKLTTSGTSISGTCAAVSGIGGPAAAGSGSSSSATASSGSGSVSASSAGAVAASSSSSTASTLTSVYTVPSVTATPATGATSTASPAQGGIFVTSGAAAASGAAATSSAHVVGTGVASSAAAASTGSSSGTGTAITAGTACTTEGMWNCVGGSSFQQCASGTWSVVQSLAAGTSCTGTEASTLDIVRRGPRPRPVRKQW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHS6</accession>
    <name>A0A3D8SHS6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_04222</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3 4">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHS6"/>
    <dbReference type="OrthoDB" id="10250441at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd23165">
        <property type="entry name" value="Prefoldin_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.370:FF:000005">
        <property type="entry name" value="Prefoldin subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016661">
        <property type="entry name" value="PFDN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100:SF9">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016477">
        <property type="entry name" value="Prefoldin_subunit_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="39"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024667"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR016477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW85897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="136" mass="15789" checksum="30F09B7AD1FB536C" modified="2019-01-16" version="1">MERRMLSKEDEAATGSDEVEVRREDQDKINKFSRLHQRELALEEELKTKHKEKEDLEDISNELELADEDDMVPYKIGDSFISLPLPEVQEMLSSSTEKIEETVGELEGKLGTIREEMTQLKVELYARFGRSINLET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SI41</accession>
    <name>A0A3D8SI41_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Beta-lactamase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_04301</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-A beta-lactamase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SI41"/>
    <dbReference type="OrthoDB" id="428260at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050789">
        <property type="entry name" value="Diverse_Enzym_Activities"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283:SF17">
        <property type="entry name" value="(LOVD), PUTATIVE (AFU_ORTHOLOGUE AFUA_5G00920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43283">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="56"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW85976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="410" mass="45646" checksum="6D0D6BF65CAF7683" modified="2019-01-16" version="1">MADTFDGTMAEDVLVHSSAVVDSLEKMLPGAVCWAVDSSGASVLPPDILGHRSVLTDAEPMSKDTVFFLASTTKLVTAVAAMQCVERGLIGLDEPVSKHLHELEHPSIIEGWRQGDDGKEEPVLRSAETPVTLRQLLTHTSGISASIFDPAYRKYNDWKGWPQRNPTSPELMTHPLRFEPGRKWIYGFGIDWAGILVGRLNNCILGDYFQKNIFAPLRMTSTTFRPTRNSEIRDRLASVTLKSKEGTLKPEPFNVWLKDSEEVEMESGGYGLFSTAEDYIRFLHTFISDHSPLLKKESIDEMFKPQLPSSQWLSENAVDPKGIVISGNIMFPDSPVSHGLGFVLAEEDLSTGCKNGAAQGGGLTNTFWWIDRKVGVTGVVFLNMLPYMDTDAVQLWVEFQTRVYNKLCKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SIC1</accession>
    <name>A0A3D8SIC1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">6-phosphogluconate dehydrogenase NADP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_03843</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HIBADH-related family. NP60 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SIC1"/>
    <dbReference type="OrthoDB" id="435038at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006115">
        <property type="entry name" value="6PGDH_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029154">
        <property type="entry name" value="HIBADH-like_NADP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015815">
        <property type="entry name" value="HIBADH-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051265">
        <property type="entry name" value="HIBADH-related_NP60_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580:SF8">
        <property type="entry name" value="6-PHOSPHOGLUCONATE DEHYDROGENASE NADP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43580">
        <property type="entry name" value="OXIDOREDUCTASE GLYR1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14833">
        <property type="entry name" value="NAD_binding_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03446">
        <property type="entry name" value="NAD_binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000103">
        <property type="entry name" value="HIBADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0520">NAD</keyword>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="6-phosphogluconate dehydrogenase NADP-binding" evidence="5">
        <location>
            <begin position="9"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="3-hydroxyisobutyrate dehydrogenase-like NAD-binding" evidence="6">
        <location>
            <begin position="176"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR000103-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW85518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="33211" checksum="592088DF5BD00B6B" modified="2019-01-16" version="1">MADTRTPRFGWIGLGNMGLAMSKNLQKHLSQKGAHALCYTNRTISRGEPLEALGGTPLTSVAEVVKVSDVVFISISADSVLEGIITEILESGSITGKIIVDTSTVHPDTSNGASTKIVQAGGSFVAAPVFGATPVAEQGKLLFALGGPSAAIDVITPYIDGVLARAVIRTGEEAASAATLKTLGNFLTAGMHLIISSAYTVTEKSGMDASVLSSLITENYGPYAASISDRLTSGAYLPPRGAKPVSDLELALKDVGHGITCAKDVGVKLDVAELVMELLGEAQSFGIAEQRSLDSTSVYGALRQRAGLEFESDVVKKRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SLP2</accession>
    <name>A0A3D8SLP2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_02931</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SLP2"/>
    <dbReference type="OrthoDB" id="288726at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="273"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="18"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="273"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW87237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="476" mass="53075" checksum="ED2C5D0DB6EC3BEB" modified="2019-01-16" version="1">MLVPEYGEDDNGQSMVPSTAITTASTTRTSAKRPLPPKDFVFVSLTPNVKSLDADYYSPDRSDDKRTMLRYYTQVLADILTTTETNNSFLSVFLPMAMDSLSLQKALMAWSSAHISSYLKSYMVRALEHRSQALQSSAGALARCSHSSSQADIEVMLATGLVLCAMDIVLGDTESWFQHLVGARDIILFACTFNSNGVVLRGPQCFRGSDSQWLLRNFAYHDIIGSLTTLEPPLIQGSYWSSGDGSIVDSYWGIGTEVLVMLSEVCALNPSEVTEEDEHEDEAEELSQQQQEREQLAHDAPLPSISASSFWKDSVRLEAKLQRWQCTNFSNLSLVKLVQAQRSTALIVLHRKQRIYCYNNPAQARRLPVITAKVAAAVQSSVYHIRRLNLDSRAAGGLLCPLFIAGGDAMESADFEFLRGSLQKMFDRRGFGNIARAIDVLDELWRLRLNGFHGPAGRPVDWIDVLERRGWRLMLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMH8</accession>
    <name>A0A3D8SMH8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_03204</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SMH8"/>
    <dbReference type="OrthoDB" id="5215911at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17323">
        <property type="entry name" value="MFS_Tpo1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000224">
        <property type="entry name" value="MFS transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF34">
        <property type="entry name" value="PROTEIN HOL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="210"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="369"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="411"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="440"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="475"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="506"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="54"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="263"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW87510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="548" mass="60927" checksum="4BE29E3F28B98DC5" modified="2019-01-16" version="1">MTSEQVDYLPGTSRLVESYDEAAISHLKKHGDIVLSPQPTNSVNDPLNWSVPRKYWNVALLCFITALTAATSNDAGSAQTGMNDEYGISYSAMNTGAGVLFVGIGYCTLLISPAAWLYGRKITYIVCLTLGVIGAIWMANVHTTMDSIWNQLFVGASEACAEANVQLSLSDMFFQHQRGTVIGVYVLSTSIGTYLGPLIGGYIADSNMGWRWVGWWSVIISCVTILVCLFTLEETSFHRDGYGINIVQGMNETVMTEEGYKNDKLDDGQAATKDISPRDSLPSPEIASENKPSYWRRMRLITPAPNLIGTGFKQYMRRLFHTLRIFGFPAVIYSGIQWGAQDAWLTFYLTLEEDNWTSAPYNYSDVGSGIMNVPCLIGAVIGCFWGGYLSDQFVIWMAKRNGGIREAEHRLWMMYPCAIFSPLGMLLFGIGTAYEWSWPVPYVALGFIGFGWGCAGDLSMAYLMDAYPEMVLEGMVGVAVVNNTIGCIFTFTASPWLSTSGTRDCFIAIGVLDFFFVMLTVPMMIWGKACRSWTKNRYLDFIRIRDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMI0</accession>
    <name>A0A3D8SMI0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Transcription elongation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BP5796_03227</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the TFS-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SMI0"/>
    <dbReference type="OrthoDB" id="44867at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001139">
        <property type="term" value="F:RNA polymerase II complex recruiting activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031440">
        <property type="term" value="P:regulation of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031564">
        <property type="term" value="P:transcription antitermination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13749">
        <property type="entry name" value="Zn-ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.10:FF:000001">
        <property type="entry name" value="Probable Transcription elongation factor S-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.30:FF:000003">
        <property type="entry name" value="Transcription elongation factor S-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.930.10:FF:000007">
        <property type="entry name" value="Transcription elongation factor S-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035100">
        <property type="entry name" value="TF_IIS-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003617">
        <property type="entry name" value="TFIIS/CRSP70_N_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006289">
        <property type="entry name" value="TFSII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01385">
        <property type="entry name" value="TFSII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF0">
        <property type="entry name" value="IP08861P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006704">
        <property type="entry name" value="TF_IIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00509">
        <property type="entry name" value="TFS2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 13" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="16">
        <location>
            <begin position="4"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS central" evidence="17">
        <location>
            <begin position="132"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS-type" evidence="15">
        <location>
            <begin position="249"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="80"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00025408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU368078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDW87533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="291" mass="32678" checksum="AFC2625B7650494A" modified="2019-01-16" version="1">MDQKELESYIKQLQKAVQEKTPEVLTIMEKLKSDVVATEELLRSTRAGLVIAKQRANPNKDVARLASEIVQKWKKTVEAEKQKRSKMASTSASPPKVDKPSPAEPEKGFVGDSSKRKWETDKVNVKRTGVPTRDNCIGLMYNGLAFKSEEPSTTIIIKAIEVEQAAFDVYKGESAEYRSKLRSLFQNLKNVQNRELGPKVMSGEITPSKFVVMSHDELKSAQQKKQDEKLMSENMKNAQVPMAERSISDALKCGKCGQKKVSYSQAQTRSADEPMTTFCECTVCGNRWKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SNT6</accession>
    <name>A0A3D8SNT6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03152</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SNT6"/>
    <dbReference type="OrthoDB" id="3600083at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="412"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="423"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="448"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="496"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="565"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="600"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW87458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="779" mass="82554" checksum="6414C85223FB3FEA" modified="2019-01-16" version="1">MSGKPTSASGGVRNLRAMFETKDEATSPPDRGRSPGTSIGGSSAGTSPRPLSKVRTSFVTVENKGGQWGLRRDTSGEPNLTKRRKSFSIDEEDHPKTTALRKESIATEMEARKNSAVVEETIPECAIETPSMDVDKQLGTVPAKEEPLAKTVAKGNVNKTEAPETKKPTSPAPAKANGALQTKPKTPVTKSEEKPASGKTTAAKAPVSKSATPSKVSPKAAKTGAVAKSPKTPTPASPTTGPSDPNISIDPEKPSSPEKSTEARRSPPAKLRIQPSPPKTGFVKPKPRSPTRPVKLPPSLTAHTASSGSKTAGTTTSPPTRQSLSRASGNVQPTSTQAGVSKSPSRAAGAKGLTRNSSTLKNASTRPSLGPPPSNLKKQPSKQNLPQKDTPPADDSFLARMMRPTASSASKTAEKGSEKASDTLPTRSQSVKRSVAKETAPATKEASKPVSKTPKSSTPVKSAVKETAKKVLPSRSKEPSAPAKPTGARPATSNVKKAEPSKPTDNKAKELKKSKTEATKPKEAKIEKPSAVEEIKKEAPIEGQDVLQEAKAEESKIEVPVTEDTTAKEPKKEGVQDPFVEDPKTEAVEEQPKIETPVLEDSKPVEAKAEEPAVEKKKEEPGPVEAKTEEPEIQEKKEEPKLEIVEAPEVKEGLKVEESKSPEEPDISEEALPAKDNIPVIEVPASIEPETAQETAPEPPVVESETAETANEPEVKEVQAPEETSSQEISIEKTDIVPTSPKEMSEDPEDVKAREEIARLNAELMGTSPASEVVRTESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SX93</accession>
    <name>A0A3D8SX93_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_02100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW90935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SX93"/>
    <dbReference type="OrthoDB" id="39175at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF25">
        <property type="entry name" value="ABC-TRANSPORTER-REGULATING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="569"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="5">
        <location>
            <begin position="17"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="66"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="642"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="706"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="642"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW90935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="725" mass="81268" checksum="3BD4B5AF334FAC9A" modified="2019-01-16" version="1">MSTGSPELLARPRLQTACTQCRTRKVRCEGSQPCANCVDRREHCEYAPVRPRRRHREPSEYINRKAEAAASSTAQPKPRISQVQAFDTPPSLPSRSSDVPGISPNHQGKYPAESEILIVPDRAAVIRLQNEGQTGKPSSSKSISTGHADVNMATHFENGQTQHSPNWQYHGPPSLLSICSFPGIDWVSSVTMLPGFFKTARGLSMMLNHRPASCPRISQDFIAEPDQETAWIFCRAYFQHSFEARLGLVFRPAFETRLRLHFMPSGDHFEDPAWFALRNTVYASGCRIHMFQSNSSFLDAQACAWKYFEKALSVHSELLFSATGLTAVEALAAMSYFVEGITAPGIEYMLCSSALRLAQSKGLHRQPATVWSLPAEEIQRRNWLFWAIYIYEKHIASRSGRPSAIDDHDISCAMPTSSPDATEVSLEFFNSVVQHARLSSLIVRHLATADAFQKPVEDLMSSTQELHEKLQSWRHSLPSELEPTAAFIPHKLPAGLNQDCFLYLRYAYAGSIIAIHSIFTMPWNKPVFDHLQSPEICNQVALSTARVVESTRSIILTTNYIELSAFTPVWLAVYYPLLGMINLFTYVLRHPLKEGIRADVALLDIAAGYFSRLEFPAPQMSTPFTKDIARLARQVIDRRAEEAASARSEKQNRDINNPAPATATAGLHHLIQAPDRHRPPQVYNQDLVDLYSENWSVLLPSFRAPASGELRNTDEPEAGMFWSES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXI8</accession>
    <name>A0A3D8SXI8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_02159</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW90994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SXI8"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903475">
        <property type="term" value="P:mitotic actomyosin contractile ring assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000003">
        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="89"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW90994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="176" mass="19551" checksum="A6F984A071D53ACF" modified="2019-01-16" version="1">MTTTMAPSNANQPPYDSQASTNYKEAFALFDKRGTQRVATDSLGDLLRACGQNPTIAEIHDLEKGLGAEFDFETFSKILNRPGGFRDPGEPEEYCRGFQVFDKDMTGFIGVGQLRYILTNLGEKMSDDEVDELLKAVDTSSGEINYTGMFAFVPWHRDEEEDADGTTDLVRTILAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXU7</accession>
    <name>A0A3D8SXU7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase epsilon subunit B</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">DNA polymerase II subunit 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_02317</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase epsilon subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SXU7"/>
    <dbReference type="OrthoDB" id="10254730at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016266">
        <property type="entry name" value="POLE2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="9">
        <location>
            <begin position="468"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="162"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="645"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="22"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="162"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW91152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="791" mass="85419" checksum="5662B8DAE1313BD8" modified="2019-01-16" version="1">MSKSNPTDKPRAAPMFKAPRTPAQTNPIPSSSPAFGTPAHPIRPFNAVPATAKQSVLPILLPPATLRPVAFRTFTKKHSLTLTSSALQVLATFIGRHCGTGWREEGLAERVLEEVAKSWKNYSKGVIVEGDSSELKDILKNLEGSMIGGRIVASRELSRQNSLNLGPSQYGDDSTTRLGLRPGSLGREDSQSSLGMSMLEMDEHDEDALKDPRKWLKVIDAFEQPRLVYNVAKKHFDRDSSKPSLLPQASHKTQVFRNRYNLIHQRILRNESFQTSAVEASKTPSLKRTSSALATAQQSYKLTPIANLLGRNGSNHMILGLLTISPTGTLAINDLTGSIALDLSHAKPVPEDGAWFAPGMIVLVDGVYEEDDNHGGTLGGSGGVGGTIGGKFIGFFIGGPPCERRSVTLGLTGTNGEGDTTAGGGFGWVDFLGVGSERAVGSKMRKLEQRLLGKRLEEGDGVGRGRMILVGEINLDQPRTLQALKKLLGIYAAEPEEDTPMTFVLMGNFVQHAVMARGGSGGSIEYKEYFDALASTLSEYPTLLQAATFIFVPGDNDGWASSFSAGAATRLPRKGIPEMFTSRIKRAFATANAEAEKEGGKRADGEAIWTSNPSRLTVFGPMHEILILRDNMSGRLRRTAVQFTSAKPSDGDGDVEMATTPALPPSATEIDEDVRDAESHEPEAISEEDKLTHDTHIARKLVKTVLDQGYLSPFGLAIRPVLWDYASALQVYPLPTAMILADTEAPAFCVTYEGCHVMNPGGIVAPGRRGVARWVEYDLLSKAGKVREALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXY7</accession>
    <name>A0A3D8SXY7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_02340</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SXY7"/>
    <dbReference type="OrthoDB" id="3529975at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="143"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW91175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="180" mass="19961" checksum="5CAACF9C73B2600E" modified="2019-01-16" version="1">MATDIMVLTLPMPMVWKLHAPRSDKMVLTAIFAFGFFMLRIKAVFGVSLTDITYSIVDSMIWSILEPGFGIVLACLPVIRPLFMQLLSKIPRKNKSNSGSSGSDNTGLSVGSGPPNKHFQLIEEHDYPLGALRPDQVKTAQRVYSTLQRDESASQTSERSPMATHGIKVDLDWEISHEVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SY90</accession>
    <name>A0A3D8SY90_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Btz domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BP5796_02431</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CASC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SY90"/>
    <dbReference type="OrthoDB" id="5413466at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035145">
        <property type="term" value="C:exon-exon junction complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018545">
        <property type="entry name" value="Btz_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044796">
        <property type="entry name" value="MLN51_plant"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46837">
        <property type="entry name" value="PROTEIN MLN51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46837:SF5">
        <property type="entry name" value="PROTEIN MLN51 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09405">
        <property type="entry name" value="Btz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01044">
        <property type="entry name" value="Btz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="10" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Btz" evidence="14">
        <location>
            <begin position="129"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="618"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="18"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="132"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="620"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="636"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDW91266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="729" mass="80243" checksum="575380FF3A56906C" modified="2019-01-16" version="1">MPYRHRRDLAASRRRVEDEGDEEGGPDHGELDDDSLTEGSIMSEDEGSETSNPDAVSPESPGHAKVNGNGILDVENGKAKSSNRRQHPTKGTSDMDMMLNGLKLSDQQGKAEEVRFEDLQEENEVPTPSPAVVSSTAQMDQPQEQPHDRRRREHEEYKRKRDADPAFVPNRGAFFMHDHRHAGPAANGFRPFGRGRGRGRGIGGPFAPVKYDAVGTHAENMMLTKSSQIPHSYEPTDAPWAHDMHEVISEPQPRHMQNPTYGNGISHAPARAPANAPETGKINRALSTTKHVGNVQIRLFFSTMEKPISFPGIPWKQYTRLPDHRPPLRRDKPVRISLPDNPPRYIYPAIERSFIFIPRAMRPNQQGFGGRGRGRSVFGSIGGYSRRTSVFGGSVYGSQYAPSVAMSRRSSLAREVGRDDIVSPSGSAMSRPQITMDPSRPVVKLPPASQPVPTQYNPAVAQDPQNGSQVAHATENHSLGPAAYPHPQIPSFPAKATPNIVSNSTPTHIHQPRPQKTVSVADIESPATLNFNPPQQLQQPFHQQVPLQVNANGFQDTMLHTRNASYPSQASTGTPLSQIPERAIHAQPFQPNPYQQQGYYPQQPYQVMPPQPGYYYPQQSFNSPMGPTAGNTPFMPAQQQQQPQYSQPQPDAATAQAPQNLVAQEVNGMVYYYDAAQIPAVNTFPTYPAATTYPMQQVGGVVGMGGMMTPSPDGFYYPQAAQGVVYYSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYP4</accession>
    <name>A0A3D8SYP4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Methionine aminopeptidase 2</fullName>
            <shortName evidence="9">MAP 2</shortName>
            <shortName evidence="9">MetAP 2</shortName>
            <ecNumber evidence="9">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_02579</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 10">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9 10">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="9"/>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYP4"/>
    <dbReference type="OrthoDB" id="7848262at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF2">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 9 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="12">
        <location>
            <begin position="132"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="334"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="429"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW91414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="448" mass="49307" checksum="A5DE702863A50F68" modified="2019-01-16" version="1">MAAQATDALANLKVKDPEAVKASAEAAIENGKNAQAEGDDSDDDEEGDKVAGEGEANGATKAKKKRKRKPKKKGGAAATKQSNPPRVLLSNLFPSGEYPVGQEVEYRDENLYRTTNEEKRHLDRMNNDFLQEYRQGAEIHRQVRQWAQQNIKPGQSLTEIAEGIEDGVRALTGHQGLEEGDNIKGGVAFPTGVNLDHIAAHYSPNAGNKTILSQDNVMKVDFGVHINGRIVDSAFTLAFDPMYDNLLEAVREATNTGIKEAGIDVRLGDIGGAIQETMESYEVEIKGQTYPVKCIRNLNGHDIQQWKIHGGKSVPIVKSNDQTKMEEGEAFAIETFGSTGNGYVHDDLECSHYARRVDAPKVALRVDSAKRLLNVINKNFGTLPFCRRYLDRLGQDKYLLGLNNLVSSGIVEAYPPLVDKKGSYTAQFEHTILLRPTVKEVISRGDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYU6</accession>
    <name>A0A3D8SYU6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">GET1</name>
        <name evidence="13" type="ORF">BP5796_02631</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the WRB/GET1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYU6"/>
    <dbReference type="OrthoDB" id="69461at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.660:FF:000006">
        <property type="entry name" value="Protein GET1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03113">
        <property type="entry name" value="Get1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028945">
        <property type="entry name" value="Get1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027538">
        <property type="entry name" value="Get1_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650:SF1">
        <property type="entry name" value="GUIDED ENTRY OF TAIL-ANCHORED PROTEINS FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42650">
        <property type="entry name" value="TAIL-ANCHORED PROTEIN INSERTION RECEPTOR WRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04420">
        <property type="entry name" value="CHD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017779541" evidence="12">
        <location>
            <begin position="21"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="topological domain" description="Lumenal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="4"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="topological domain" description="Cytoplasmic" evidence="9">
        <location>
            <begin position="171"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="188"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="205"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW91466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="216" mass="24027" checksum="749292031C7A9B2A" modified="2019-01-16" version="1">MPSVLLITFIVQLLIHLVNTVGASTVNAVLWTIFTRLTNSKAAVEQRALKTKFLQLKKELNATSSQDEFAKWAKLRRQHDKVLEEYETSKKGQDSTKATFDKVVSALRWLGTNGLRTILQFWYSKQAMFWIPQGWVPYYAEWLLSFPRAPLGSVSIQAWVLACGAVILLFNDAIIAVCALVMEAASSKKVQPGKGAPMKVPAGKAGDEKSAEKKEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYY5</accession>
    <name>A0A3D8SYY5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">U-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_02687</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYY5"/>
    <dbReference type="OrthoDB" id="20295at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000055">
        <property type="entry name" value="Ubiquitin conjugation factor e4 a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0697">Rotamase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="13">
        <location>
            <begin position="1007"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1078"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="543"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW91522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1105" mass="125472" checksum="232061E057EE891D" modified="2019-01-16" version="1">MENDQQPPQPPPASTPDAPDKEKMDQIRRRRMEKLSGPPVQRSEVYADASTEAPSSAKPTPVSTPPPGAVSTKPKINVRPAQPTAENPFTKLGAQQSNENSPVSNVSKASMPKRSRAESGEQTPKPVKKVVKEAVEETIEDYEHRILSNIFRITLDPNQKADSSNHRLTYLPNLRQELEDSSDPLKFSVVNLDSAVLEACSTVPHNKPILDYLLPCWKRCIKALKGLKGYASAKDAILKEARRLCMSNCIFAVTVPELFSREPNPATDSLTPYLLLEPEDDRGICLDFLTEAVSRFEEDDSVKSMLVQAVTGLSLQLSNITMNDNYKPYVNALKRISHFAPAVTAISESPLFVMAQSAPGIEKHTLLGPFFRISPLQMEVTQTYFAGPKTMDKRHIASAQDALRLTLQNHQQDLLDIINFFVRASPTSKNKTLDWFAWIVNANHKRRALQLDPRAVSTDGFMMNVTVVLDGLCEPFMDTTFSKISKIDVEYLRREPRVEIKDETKLNADQNASDEYYSVKAPGVSNFISEVFFLTLAAHHYGSEATNTNLKNLEKDIKHLQKQMVLMEAERQKLQTRPRELAALDAQLKRYVDALDRAISLQYAIQGVLFDKKMQQRSLTFMRYVTVWLLRVASGTDYTPDRALKLPLSEEQPRAFTVLPEYVLEDIVGNFNFIFRYVPDVMISAVGDEIMTLCITFLTNSKYIKNPYLKAKLVSLLFHGTWPVYHRTKGVLGDTLTGSKFANEYLLHALMKFYIECEQTGAHTQFYDKFNIRYEIFQVIKCIWTNDVYRQKLKQESRTDIDFFVQFVNLLLNDATYVLDESLTKFPKIHDLEIELRQPQSALTPEERTAKEEELQTAEGQAQSYMQLANETMSMMKLFTGALGETFTMKEIVGRLASMLDYNLDSLTGPKSSNLKVGDPGKYGFHPKTLLSDFVEIYLNLGMFEPFVEAVSKDGRSYKPANFDSASRIMIRHGLKSPEDMEKWEKLKERFKLAKEIAETEEDDLGEIPEEFKDPLMDEIMTDPVILPMSKATLDRDTIRQHLLSDPTDPYNRQPMKIEDVIPNVELKAQIDAFREKRKREKQERVNALKAEQAATTGDPMDTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYY6</accession>
    <name>A0A3D8SYY6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Asl1-like glycosyl hydrolase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_02702</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYY6"/>
    <dbReference type="OrthoDB" id="43654at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009277">
        <property type="term" value="C:fungal-type cell wall"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071966">
        <property type="term" value="P:fungal-type cell wall polysaccharide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053183">
        <property type="entry name" value="ASL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024655">
        <property type="entry name" value="Asl1_glyco_hydro_catalytic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34154:SF3">
        <property type="entry name" value="ALKALI-SENSITIVE LINKAGE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11790">
        <property type="entry name" value="Glyco_hydro_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Asl1-like glycosyl hydrolase catalytic" evidence="2">
        <location>
            <begin position="62"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW91537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="278" mass="31594" checksum="5B92A3832E7D8B53" modified="2019-01-16" version="1">MAAPSLPPRANKPPPPPVPRSTKPNLPKRFPAIKKKRCLLWDWTCTDEKNGVPWAMDKIDFQYVSSVCNWNAWTPPELKDRVPFRPMVRTEGQLEGWEWTAISETKEPIIHFFNEPERIPIAAEKAADIWMERMVPLQTKGKKVSSPGCASDPGGEAWLDKFMSLTSSHPPDFLNLHYYGPDGNGAIAYLEKLHSKYPGLPVIVSEIACISRDIGQVHAFTKRLVNWMDETDWIFEYAFFGCMPKPADEFVSPQAQLMNEDGSFTALMKKLMIEQPMT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZ63</accession>
    <name>A0A3D8SZ63_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_02767</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZ63"/>
    <dbReference type="OrthoDB" id="1939598at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14705">
        <property type="entry name" value="bZIP_Zip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.5.170:FF:000075">
        <property type="entry name" value="BZIP transcription factor (MetR)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004827">
        <property type="entry name" value="bZIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044">
        <property type="entry name" value="ACTIVATING TRANSCRIPTION FACTOR ATF 4/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13044:SF14">
        <property type="entry name" value="CRYPTOCEPHAL, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07716">
        <property type="entry name" value="bZIP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50217">
        <property type="entry name" value="BZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00036">
        <property type="entry name" value="BZIP_BASIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="BZIP" evidence="7">
        <location>
            <begin position="158"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="120"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="122"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="182"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW91602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="256" mass="28332" checksum="C970F534AC64BC39" modified="2019-01-16" version="1">MSAYNGRRGPNVSEYIANLNAIPSAQDLANQQEYANLDEDLAMFTNTQFFDFDLGQDTDFSADFNATQREEGAPAEELEGDVKPLDFIQGDFSFTDFNAFAQPPSFDLDGMPQLPTMEPVVAASSASSSSPAASEEQTPAPANELKRKASTIEESSRAAAEEDKRRRNTAASARFRVKKKQREAALERSAKEMSDKVAALEGRINLLETENKWLKNLIVEKNENKDDIAALWLKYTQDQELERSSSERKDGVGTSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZT7</accession>
    <name>A0A3D8SZT7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Acetamidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_01231</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZT7"/>
    <dbReference type="OrthoDB" id="3335528at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016811">
        <property type="term" value="F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.580">
        <property type="entry name" value="Acetamidase/Formamidase-like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.28.20">
        <property type="entry name" value="Acetamidase/Formamidase-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004304">
        <property type="entry name" value="FmdA_AmdA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891">
        <property type="entry name" value="FORMAMIDASE C869.04-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31891:SF1">
        <property type="entry name" value="FORMAMIDASE C869.04-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03069">
        <property type="entry name" value="FmdA_AmdA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141130">
        <property type="entry name" value="Acetamidase/Formamidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW91837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="323" mass="34379" checksum="1157273AB094853B" modified="2019-01-16" version="1">MPSSFHVHDHNVHLKWDNAIPPVLTVDSGSEVSFDLLDGGHNQFTPASTSADVPNFNLALGDPAMGPVYINGAEAGDVLKVEFLALQTAAYGWTAILPGSFGFGILADEFPEPALKIWDLESHAAEGYAVFKEGIHIPLRPFLGVVGLAHEAAGQFSTIPPYETGGNIDCKHITVGSTLYLPVKVKGALFSCGDGHAAQGDGEVCGTAIETPMKATVRLSVEKGKPWVKSPHYVTDPVHSQTVGGQRGEYAALGIDADMREATRKAVRGLVEWLVGEKGLTRDEAYMLASVAGDLKLAEVVDMPHYAVACSLPLSVFVGEKYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZU5</accession>
    <name>A0A3D8SZU5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase-18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_01163</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZU5"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF31">
        <property type="entry name" value="LAEA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="339" mass="38254" checksum="EEF190D2DDBD4964" modified="2019-01-16" version="1">MTTEQQVAISPPGPASPGPIEAEVDNWDDDSAVGGVSLASSKTSITSSILRYREENGRTYHGFKDGQYAFPNDEPENDRLDLQHHVFMLTLGGKLFSAPIPKEQTLHRVLDVGTGTGIWAVDFADENPESEVVGVDLSPIEPRFVPPNLIFEIDDLEEPWTFSKPFDFIMARLTVQFFSDPARYMQQAFGSLSSGGWIECIDIVNPSKSDDHPNFQETQLWKWGHYRAEAAVKLRGSVSAAKRYKEQMEAAGFVNVKEIIYKWPTNRWPKDKKLKELGMWVNEDIQPSLEGLSYAAFTRGLGWSKEEIEVFLTGVRRDMNDTKIHAYWEIYAVSGQKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T019</accession>
    <name>A0A3D8T019_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_01307</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T019"/>
    <dbReference type="OrthoDB" id="5279415at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="405"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="452" mass="51801" checksum="AFD35D052323C28A" modified="2019-01-16" version="1">MSHHHGTECTCMLDGPDYPEPSAAEVRFDMLLTENKRILDENQKLRDLLDEHGINYRANIAAKRRRTSTRLNRDLPLLPKELQLKILNHALTCQFPIIDPFYKPRLENLTVEEKRSRRKIPIHWLAVCKDFHAEGVPMFVTTNKFIFTQVAALQQFANIPREVRSTIDFVTLRIVGRYYDNEARKQNLFGNQYHPGLRDYRLPILARPPGAEMDKGIHAYCYHQFGDFLRALQVSKEVPGFSRSIQKLFPGLKSMRIDLVNFTEYLWYPGRDFSSIIRWQTGPLVEELIITGVPEDDPEEGVETLIDRMVQNEGVFASGPPIFYSMTKNLRSLNPLGLAVRVVRAEKDVSKIDFKKAAAAHPTGGKPPPSFHRPGRTIWKYTQDSLSKPEKKWIEFDRKSGYPAEDVDDLMTDFDDEDDFFDSELGLDDDESGDADSDDSSTGFADMPDLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0K4</accession>
    <name>A0A3D8T0K4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_02703</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0K4"/>
    <dbReference type="OrthoDB" id="2162761at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051615">
        <property type="entry name" value="Transcr_Regulatory_Elem"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313:SF4">
        <property type="entry name" value="CONIDIAL DEVELOPMENT PROTEIN FLUFFY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31313">
        <property type="entry name" value="TY1 ENHANCER ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="9">
        <location>
            <begin position="171"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="583"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="584"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW91538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="717" mass="80010" checksum="AFCD4CFCB0594668" modified="2019-01-16" version="1">MDLTDRKQCDGTRPTCSACVTVYNTECFYDIDSDRRRKGALKRDIKHLIEDNERREFILDALRNAADADLDDVVQIIRSDRTYEAIAEALENLNLNLTTRNHSERPTLEGELADFVGKPCTDKDGQTRLYGHTSNLAILGNDEAVHSKAIIEAVTWTKVTSDVEFIKHLFNLYFAWSHPFYVLFPQETFFKAMRDRNTKYCSPLLVNAVLAVGCHFSDRPEARADPKDPSTVGEHFFAEARRILCDEVQSDAAYTMLTTVQALGVMSLKSAMTGADSPGWKFSSSMMAMSIELGLQTSLNTLSNSKISAIEDEARRVTFWGCYVLHTAWAICIGRISLMPQAAITVDKVPLKDSLEIKPWTPFGCPQREKLVQAGYTYTVLGQTAMLTEIVNEAVHMFYAPQGRTTSRKVLDLHFQMQRWYAQLPEALAVQPEGHPTTAQVFALHIYYHNCVLHLFRPFLRVTFVQAAKPPHLVCMESARAITQLVALYKHYYGLRRVPLIVTHCTMTAAIQHLVNLSSAKHDVATQAAADLGETISAISNMAQRAPMSKRFFAILMGLIRRWAVKVPENVQNAMAEAEVEFASTESSSSVNMSPPLILSSSTNSEETLRRNDPGPEPMPRPGLMNDHSSRPVPTSQPLQLGPNPFWTPFPGAFDGLPVAHPVPEAFLPQQHMDISCMLDSGVDGDWAQLNRDGFTMANAGVGLDPNLWKWNGNLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0U9</accession>
    <name>A0A3D8T0U9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF300-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_01558</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0U9"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="252"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="360"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="466"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="374"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="502"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW92164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="551" mass="61776" checksum="211993C1B174F882" modified="2019-01-16" version="1">MHGREPVNHLWPLNRCLPKVDISDPHTFLAIKRGILQYAWLKPILGLASIIMKSTGTYQEGYIGLTSGYLWSGILYNISVTLSLYSLGMFWVCMSKDLQPFRPVPKFLCIKLIIFASYWQGFFLSILVWLGAIPDDVQGYTPDNLAAAIQDALICCEMPLFAIGHWYAFSWHDYADDTISSARLPVKYAVRDAFGIRDLIEDSKETFSGNKYEYRLFDSGDNVLAHEGSSSRVARLMEGMRYERGGKGKYWIPKPGEATSKTPLLGHDGGPSRPRSTSPIQHDDGMLGSGKGTLEAHGLDLEEEDLYSRAKALEFGDWNYPVITAHVPSRERWLRAQPELLTTSANRNLLQPTQDNEIHRASNIRETVDEVTSHRTKSKRKSSSKGKAKAVGEGEEGRAPMLKGTLRHHSSGSSSVKSDRSQLVDLVVEDTTAEATERVRARKEGSAGWNETEPKRYVRTYGTEAGEDIREGFEPTDDVAVVDPKEEDEPDRFAVGGDEDDRDHSPADSEESKQWQEEREAEVKLKPKYGFEGEALENVWGEPSEVARENP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T181</accession>
    <name>A0A3D8T181_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GmrSD restriction endonucleases N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_01717</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T181"/>
    <dbReference type="OrthoDB" id="5419821at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004919">
        <property type="entry name" value="GmrSD_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39639">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39639:SF1">
        <property type="entry name" value="DUF262 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03235">
        <property type="entry name" value="GmrSD_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GmrSD restriction endonucleases N-terminal" evidence="2">
        <location>
            <begin position="138"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="503"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW92323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="563" mass="64458" checksum="BDA0398256F4A6CD" modified="2019-01-16" version="1">MMMSVANPVMYCGPEARIMVKPDPDMIMGPSRPVRRSTSRKKDSTIPRTEPAKAIVTSKGSTPSNTFVEMPKLEVKSETQDDQSGIRSEDDDPFDDFEYVDDNYEGVAEDEEGTEYFVCKEMKIPQVPKAEIFMRRLGDLYKLSKTKYMDLEPEYQREVVWDEHRASELIKSIFIGYFIPPLIFNLISKTEKDGCGKKVEKYYRVCVDGKQRMTSVVKFMDGLIGFYDSSHPPKKWFYSHPIINGVEKITNHNIMPEVMKKRFRESQFCCYEYDNLNLTTEETMFQLVQRGIALTPAERMKAMSTEWAQFTKRYEEDYCLVVNLSKQNRASGFRVVLTIFTMIQEVGAHAENTDSKKGMPTLQSSPQALSKVLDDKKPISEALKSEFKDVFDKFEALVKQCSTKLPSGAWKINRDSPFDPAPDFLREDAVNHVKTYSPLELLATGILIAKYMGERSDELLLGDIQEMRHFLREKHKDLRVNAQCWISTWDFLDHELLLRRGGPGGTPLPDLQRHTSKTPSTPRTDSENEGSVEGSSKRVRQDGAADGETNADLIPSRPKRSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1A6</accession>
    <name>A0A3D8T1A6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acetyltransferase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_01708</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1A6"/>
    <dbReference type="OrthoDB" id="9975416at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050832">
        <property type="entry name" value="Bact_Acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43877:SF2">
        <property type="entry name" value="AMINOALKYLPHOSPHONATE N-ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43877">
        <property type="entry name" value="AMINOALKYLPHOSPHONATE N-ACETYLTRANSFERASE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="17"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW92314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="187" mass="20581" checksum="885F701E58983D5A" modified="2019-01-16" version="1">MGENTADLVTPVPKAQVLLRPAAEKDVQAISTLGAYVFSSTFGYSMPASDLAAYLEDAYSLASIARDLANPLADIIVAVDPQDTVMGFVQLTQGTTEPCLEGVESPIELQRLYVGQDFHGSGVGRKLYETVEGMARQRGFKTLWLGVWEENFTAQKVYERFGFSKIGMHDFVMGECVQTDWILSKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1B7</accession>
    <name>A0A3D8T1B7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FMN-binding split barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_01718</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1B7"/>
    <dbReference type="OrthoDB" id="2138282at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.110.10">
        <property type="entry name" value="Electron Transport, Fmn-binding Protein, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055343">
        <property type="entry name" value="CREG_beta-barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012349">
        <property type="entry name" value="Split_barrel_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37273:SF1">
        <property type="entry name" value="ADL397C-AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37273">
        <property type="entry name" value="CHROMOSOME 8, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13883">
        <property type="entry name" value="CREG_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50475">
        <property type="entry name" value="FMN-binding split barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017628789" evidence="1">
        <location>
            <begin position="17"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="CREG-like beta-barrel" evidence="2">
        <location>
            <begin position="40"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW92324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="262" mass="29032" checksum="37C140543C24B77A" modified="2019-01-16" version="1">MHFTTLLPLLPLLVRSSSVPSSPRSLFANPSDDQNALRIPTSYESAVMARRILHLTPLGTLSTVFPSPSHLQDGESSSTLEQRPAGLSGVPIGLMDYIADCETGGDPTILAINIATSFKNAAAGSNISLSLQWTPPHPPSSRIKSWFSSPGDAVPYSAANLPRFSLLGYLEKMEDTADLRQCFVDVHPDAKYWLPGNKIHSAEWVRLVVQDIYWVGGFGDRAYIGWIPVEEWRNVTKSEWEEIRLPGEKKGWKEWSVSGWEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T231</accession>
    <name>A0A3D8T231_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pseudouridine-5'-phosphate glycosidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_02031</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T231"/>
    <dbReference type="OrthoDB" id="198885at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004730">
        <property type="term" value="F:pseudouridylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1790.10">
        <property type="entry name" value="Indigoidine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022830">
        <property type="entry name" value="Indigdn_synthA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007342">
        <property type="entry name" value="PsuG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909:SF1">
        <property type="entry name" value="CARBOHYDRATE KINASE PFKB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42909">
        <property type="entry name" value="ZGC:136858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04227">
        <property type="entry name" value="Indigoidine_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110581">
        <property type="entry name" value="Indigoidine synthase A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW92637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="39193" checksum="0E9EF1FA2677A5A9" modified="2019-01-16" version="1">MYLFRTGVESITGRRTVRSTVGHISISPARYRFYSTQKPRQKFDSKVFRVSEEVEDAVRTGKPVVALESTIYTHGYPPEQNGDLAVLLEDVLRENGVVPATIAVVDGAARVGLSTEELRRLASVAGKPEAMKVSRRDLPYIIGLGLAGRPFQGGTTISGSMVLAQMAGIEILGTGGLGGVHRGGQDTMDISADLTELGRTNITVISSGCKSFLDLSRTLEYLETQGVCVSTFADGRAENDIDIPSFYCRNSGIRSPTIVQDETEAAAIIYAQRQLGLSSGIFFANPIPASHSIPQSELEDVIDTAVQEAIEQGYHGASNTPFILAKIKERTGKVILANKAMMERNVTRAAKVSVELSRIAVKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7J5</accession>
    <name>A0A3D8T7J5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Probable acetate kinase</fullName>
            <ecNumber evidence="5">2.7.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Acetokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_00289</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP = acetyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:11352"/>
            <dbReference type="ChEBI" id="CHEBI:22191"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5">Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the acetokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.1" evidence="5"/>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7J5"/>
    <dbReference type="OrthoDB" id="67445at2759"/>
    <dbReference type="UniPathway" id="UPA00340">
        <property type="reaction ID" value="UER00458"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008776">
        <property type="term" value="F:acetate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006083">
        <property type="term" value="P:acetate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006085">
        <property type="term" value="P:acetyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00020">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004372">
        <property type="entry name" value="Ac/propionate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000890">
        <property type="entry name" value="Aliphatic_acid_kin_short-chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023865">
        <property type="entry name" value="Aliphatic_acid_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00016">
        <property type="entry name" value="ackA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060">
        <property type="entry name" value="ACETATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21060:SF15">
        <property type="entry name" value="ACETATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00871">
        <property type="entry name" value="Acetate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000722">
        <property type="entry name" value="Acetate_prop_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00471">
        <property type="entry name" value="ACETATEKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01075">
        <property type="entry name" value="ACETATE_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01076">
        <property type="entry name" value="ACETATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 5 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="9"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="16"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="101"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="217"/>
            <end position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="5">
        <location>
            <position position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW94526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="419" mass="45798" checksum="ADCCF180CD8A8C41" modified="2019-01-16" version="1">MAKVVLSINAGSSSVKISVYSAEQGQAPTQLAEIQVSGLTSPPAQLEYVRGDNTVSKDEKVKGKEIKTQNDAFKFMLEHLAGDKELDAIKKKEDIAITCHRVVHGGNYTEPQIITKDTYHHLEALTDLAPLHNASALEIIKSCIAEVPHARNIAVFDSQFHQTLPKHIYTYPIDLEIAKKNRLRKYGFHGISYSFITREVAQFLGKAESETSLIILHLGSGASACAVQNGKSIDTSMGLTPLAGLPGATRSGSLDPSLVFHYATNVGKLSPSSTKELHISRAEEILNKESGWKSLTGTTNFGEITKTASSNPTNKLAFDIFVDRICNYIGSYYVSLHGQVDALVFAGGIGEKSEQLREKVMSEVGCLGFEADETLNGKKIEDVVQEVGKKDAKHKTLVCQTNEQFEMARYCAMDEKLFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7M6</accession>
    <name>A0A3D8T7M6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_00320</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the engrailed homeobox family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7M6"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050720">
        <property type="entry name" value="Engrailed_Homeobox_TFs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017970">
        <property type="entry name" value="Homeobox_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24341">
        <property type="entry name" value="HOMEOBOX PROTEIN ENGRAILED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24341:SF6">
        <property type="entry name" value="HOMEOBOX PROTEIN INVECTED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00027">
        <property type="entry name" value="HOMEOBOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 6 7" id="KW-0371">Homeobox</keyword>
    <keyword evidence="5 6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="9">
        <location>
            <begin position="47"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="6">
        <location>
            <begin position="49"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="297"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="590"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="297"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="318"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="600"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW94557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="622" mass="68693" checksum="DF800A2B0115B515" modified="2019-01-16" version="1">MDHHFHQIPQYEQHYSHHQALQHLPSHQLAFDRHYDNHSPMIAMPVQQKTETKPRLGKDEVELLEREFQKNPKPTTNTKKQFAEQMSVDLSRINNWFQNRRAKRKQEKKQEAYEAGQREALGYTDDDSSDFFNPCAVYDEGSVASVPQQSYSLISGPPPATAPYNPRYSDPTEASLESLQRTMAAAQAISQQEFHEGFIRPNDNLPHFGGPLVIHSGPSVDRARFPAANSVPRFENTLYSDTPSLLPYEAPHSVDGFSPSPVMNDTPTMFTGFPMASEPATMSPQMMTAFPSQLLSLASSQTPEDSSGSTLADDAHSTENSLSPPASGSFRSPPPPMDIAARRKKVQHRPAALGMDTIRSRPQLGPRTVSQAESFRRPLASPSSSPMRRIASAGGNNAVMSGRIYKAGIRSAQRSPIDAKFLTDVMERNYHTTPQVLSLTAGSSLNSSLAPPTPMSPLEMTVRSSTNGSSSSPESHMNYMFNGSGHDLLQSDGDVNLTSPPDTPAPNMWFMSSNEWKYNMNDEPLFTPAHDEFPTQFHMDMQTPAYLSASQPVTPAFGEFNQNLMFPNDSPQYTLGSSANAEYTFPDSLQQCGPGFVPGSSPSQKQKTFQFSNSTPADFTEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8Y1</accession>
    <name>A0A3D8T8Y1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_00759</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056693">
        <property type="entry name" value="DUF7791"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25053">
        <property type="entry name" value="DUF7791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="291"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7791" evidence="4">
        <location>
            <begin position="567"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1096"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1160"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1318"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1106"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1171"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1217"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1273"/>
            <end position="1284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1335"/>
            <end position="1350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW94996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1376" mass="156196" checksum="C22446475A314795" modified="2019-01-16" version="1">MMDPMTAFGLAANVCQFVDFTIQVVSKGNKLRKSAEGLLVEHADLYATSLKIIHLNNRLVESANASANASANASANASANAHSQYAGLLGTDREIQQTCNAMTQVASDLLKVLDKLRMPNQKGRWRSMRQAVKAMIGKNAVDKMRNDLLVHRQRLDTALLSAIWTKMDIFLSAKGYKEGDNSLASDTKMRRKAVNFLFASTQERPPLWQTRLVHQVLENDWKTHQKANTESFSGEISRNAARSTREQLQLQLIHELRFPDLSDREYRVTAAHENTFHWIFEGPNHQHIRKWRLFASWLQGSEKVYWITGKPGSGKSTLMKFLSVDPRTKINLSVWTAGLSLVTAHFYFWNSGSHVQMSRHGFYRTVVHAILSKMPHLVPTALPDRWSNSKLFGEDLHDWTDQELHQAFEKLIAKSGHSYRLCLFIDGLDEYEGDHDAFVQELSSLAAVHDVKMCIASRPWPVFENAFSTGAHLTLQDLTFPDIVRFAWSKLHGHTAFQNLLALEADYAGNLILEIANKSTGVFLWVDLVTKSLLQGLTNADGVQDLQRRLEEMASDLEKLYLKMFESIEPFYKEHASRYFQIAMAATGQLSALTFFFADDEDPSIALKTKLGPLTNEDRQLRYQIIKTRLNGRCKGFLEIPNPASVQASSISSENTLVAGSTTHDEENIDHEDEDESSTVIRRAFNTEDGSWYYKAERGTAAEEEEEEDLSTSGENIEFPASILEPDRKVTYLHRTAKDFLETTEMRQKILETSPSGFDPHISLLSSRLLLIKTLPVNMVNRTILWHEIQAFLEFAAVAETAMGSPIINEYLDKLDKTASQMFSDFRLCGGGRHWTTTRWTSADSQREIGFLSLAAEYNLKQYIRSKLEFGIPIFESNEGRPILDYIIEDYRNYPSLCEPSASGEAIPSLRIIKILLDRGEDANSLFKNSTTWSRALDEASRIAFDTEIQGAQKQSYLTHWADIVETFIKYEADPLVNRNSPMASRVREIFGPFLPQRAKDLEKQLKMTKKRWTSIGKYITPRNWKLEKLGFETTPLPVLKRLETAVIAPLPWSEYIKPRPGSAPVLIDDVDEEHRREMGTLSEMAERHRVDPYGLSAPRLKGSSHLETTGLSTPGYRSTIEAREAQTRREARFLRPAFSRLPLTALAADSMVNSRISGDREINPRFSQNTHERVERRRAATEASYDRYHSQMVQSTPEMRESQARHRRIRPILESSRSDEIHRQPAEDSHDRTGRESPPSGAEYPRQEGSSALIHDPQDVWTGRAPVFNDPSVDRETNGDKTGQHQRRMVKSKEKVEPKVATLSGVPQALAPYFSEQNTELQDKDDIPSEEFMTPTTAYTNSTVDSSTRPPSPIDSRLASLTLSGNRKFGRHYRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9I7</accession>
    <name>A0A3D8T9I7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">5'-3' exoribonuclease 1</fullName>
            <ecNumber evidence="5">3.1.13.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_00986</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the 5'-3' exonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.-" evidence="5"/>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12390:FF:000002">
        <property type="entry name" value="5'-3' exoribonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.260.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016494">
        <property type="entry name" value="5_3_exoribonuclease_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041385">
        <property type="entry name" value="SH3_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040992">
        <property type="entry name" value="XRN1_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047007">
        <property type="entry name" value="XRN1_D1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041106">
        <property type="entry name" value="XRN1_D2_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047008">
        <property type="entry name" value="XRN1_SH3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF7">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18129">
        <property type="entry name" value="SH3_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18332">
        <property type="entry name" value="XRN1_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18334">
        <property type="entry name" value="XRN1_D2_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006743">
        <property type="entry name" value="Exonuclease_Xnr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0866">Nonsense-mediated mRNA decay</keyword>
    <keyword evidence="1 5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="7">
        <location>
            <begin position="1"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="8">
        <location>
            <begin position="275"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 D1" evidence="10">
        <location>
            <begin position="716"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease Xrn1 D2/D3" evidence="11">
        <location>
            <begin position="909"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 SH3-like" evidence="9">
        <location>
            <begin position="1152"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1231"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1330"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1254"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1295"/>
            <end position="1306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="1334"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1376"/>
            <end position="1394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR006743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF18332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF18334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW95223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1407" mass="159071" checksum="730A60E50B49A526" modified="2019-01-16" version="1">MGVPKFFRWLSERYPAISQLIAENRIPEFDCLYLDMNGIIHNCTHKDSDDATFRMTEEQMFISIFNYIEHLYGKIKPKQLFFMAIDGVAPRAKMNQQRARRFRTALDVEVARDKAIREGKEMPKEEAFDSNAITPGTAFMHKLTQQLKYFINKKVSEDVDWQGVEIVLSGHEVPGEGEHKIMEYIRQAKAQPNYDSNVRHCLYGLDADLIMLGLLSHDPHFCLLREEVTFGRQNKAKSKELEHQNFYLMHLCIVREYLELEFQELTEPGALTFPFDLERVIDDFILMTFFVGNDFLPNLPNLHINEGALALMFKLYKTVLPKQEGYINEGGVINMPRLAALLDELQHVEYRFFESESSDQKWFKGKQMAKEDVMVKGKAKGKVVMTTAQKEVWKQVKTYVSTRSLKPLDLSSKLPAADRKFVEELAESLHLQWKTVADDNGERHMQLSFPEKMELDDEDEEDEESQLAILRVVKQYDNAQVLDVTKEMAQAEMDRKYEEKFQEWKDKYYEGKFEWNRKNEAELTKLSENYVQGLQWVLYYYYRGIVSWPWYYAYHYSPMISDVVKGLNADLNFKLGQPFHPYEQLMGVLPDRSKQIVPTVYHDLMTDPKSPIIDFYPRDFELDMNGKKMEWEAVVKIPFIDQDRLLAAMAPRNELLSPDEKMRNEFGVPLKFTFDPDVDYQYPTSLVGVFPDIPHCRCIENIFDMPTIEGLDFHTGLMEGAKLREAALAGFPSLATLPYNATLGFHGVNVFQQDSRNESMVVTIEDTESRTKIQRAIDRLGARVHVGYPFLTEAKIVRVSDELFDYTLPEDGSAHPVQQHHGPREIDMWKKKAERIESVYSKRLGIIIGPVESIVHVEMLKGLKKTDDGATIKEYAVQHGTETDYATQVIVDEVISEDQRFLEKAAVSIEEEFPLGSRAFFLGEFNYGRPLQVQGHHDNKAEIWLSTMKGKEPDFGLEIVRKAQSENSYIPSYTVAKMLQLHPLVLSKITSSFSVSAIGQMRLNLGLNLKFESKKLKVLGYSRRSDNGWEFSPKAIELLSQYMTKFPEFIAGIQRKPQGNEYDETDFYPKEIAATKIKEIVAWLKTIESKHFEKVPLDAAQLDSDVVMAIEHAADQILAKTGPDAVGFKKLKGVPRNALMKPSDAEHRLGHQHFRLGDRVVYVQDSGRVPIATRGTVVGISRTPRTILLDVVFDLTFMSGTSLGDRCSPFRGSTVPITSVLNLSNKQVEASSKAAVEKRPASTSTPLTLNGHKGQNGYGPPGGPGGKGQFREAGAPPALRGSFRGAVTGQQNGFRGNGTRGRGRGGITADINAQPAVHSSMALRDPAIIQQGIPNGGVNGTRGRGGFRGRGNGTPPVPQNYNAMPPPASLDNQRGARGRGGFRGRGRGGPHRGRGGATTQPIPPPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q4Q8</accession>
    <name>A0A3D8Q4Q8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_13216</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000028">
        <property type="protein sequence ID" value="RDW56394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q4Q8"/>
    <dbReference type="OrthoDB" id="3515070at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054293">
        <property type="entry name" value="DUF7029"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055647">
        <property type="entry name" value="DUF7223"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22974">
        <property type="entry name" value="DUF7029"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23865">
        <property type="entry name" value="DUF7223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017798389" evidence="1">
        <location>
            <begin position="23"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7029" evidence="2">
        <location>
            <begin position="178"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7223" evidence="3">
        <location>
            <begin position="492"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW56394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="919" mass="96992" checksum="7584F4EE4C97E2E9" modified="2019-01-16" version="1">MPKLPGFSALCVAAVHFLVVNAFVARENEARYDIDIEIETVYSTTEVVTRTAYVEDCPSDLPTDLVTLTQVAYVVPTGLPVEYDHTVTETETFMLAEDIMTHMPPATTAVVEFISSQAEPTQTFAAPEATLQPAVLFNIDLKNLTNLIPCDNHDLYYTADGVADPSTDHGYALLNANYSAVAVVLEHSAFVASVTCQSTALNVTFTTEEAFQVVQQSWSEPETFILVTHTFGCSEVPANDTTSRTFFKIFGVAFSGLSAIVTALEVPFEEAINEVEMSWGTYNPNPDNALPTLTDSFGQPLATPLATALASPVPSLVPACGAPPAPTISGFPAAACGDDFDYTLDSLLGFVSFGDSTFSATLQSVAPGLDDYQLKDYQNTSLAIRGPVIEKRFFGFFKFLKKIAKAAVNLVKSIPAVIKTVVKTAVAVVKVGIAIVTAVATGVVNPSVDETFNINLGPKNLVKSPFGDAYQLFQKTGTSKGGAATGSVAGYCVGCGVTGMARVQGKMSFSILQAKLTEGSVGINGNIKAGLGFGIHAEATYSDTFTREIISIPIGGFSIPKIVTIGPVIALDVDLNVDVKAVGDLLITAEASLPNFAAKLDLVDSKKSSQTGFEPKITTKFSVTGEIVASANLGVPLTVGVGITIPIISEGPSGRKLIAVKSRPGIKATAQYSIANKVINQKPCNNGVALNVTVTEDTTLDFFGLAKVNLYNYESPPLISTCLSLSKAKATPKPRLLHRRQAGNNAGSSTIVPTATTLSAVIDNSPTDAAFKSLESLAVSNNAALASGTNNANGLNYTTATDSTGKYLLAAGDNGNFYVETKSVGRVDGATIFALSDNIIVTDESDRFIFYYPDTMAKFGVSRVRLGNDTTFPKTADIVSLVPLDFDDSAVTPGVYVAVGTTQGTNAAKTYFYPVICNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q584</accession>
    <name>A0A3D8Q584_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12914</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000024">
        <property type="protein sequence ID" value="RDW56847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q584"/>
    <dbReference type="OrthoDB" id="4191831at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW56847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="51772" checksum="6B1502CA508A1FC3" modified="2019-01-16" version="1">MVTLLDLSPELVHRIVLSLARSDPHPKFHNDTELSRLAATCQTLHQITEPLLYSKFRQRLDLHHSQTQLFLRTILKNPALAAQVKYLALSQTDFIYDREYWDEDKDEDGDESKQGSDKGESSVYSNEKRNREGPYANAVIAAFENLHIASESRETWVAAIRKRNQDALTAILLLSHPNVEELSISLTEQDEDGGYLQSALKNAIHMKPEPASGPFLKALRHVKCDHRCYDGSFGIEEVEYFFYIPSLRTLSFSSLSVYNLSWHPAPTSSNIEVLDLTSCGVDSAAWASLLTPLKFLKKLIYSPGNPKFVEFADTAPSAIGASLTVVKNTLESLSLTKFYFRGANDRDFLGSLKFFPRLKEVDVHLAMLIGTKDLRRSEMLWELLPSSLEELVVMNARSGYGHEQDREDSIDQLLECIARKATEFPRLKKLTVPHTFGSVKVLSVVCEANGVLLMRRLVP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q617</accession>
    <name>A0A3D8Q617_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_12712</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q617"/>
    <dbReference type="OrthoDB" id="194139at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507:SF1">
        <property type="entry name" value="FI18259P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23507">
        <property type="entry name" value="ZGC:174356"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="126"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="283"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="332"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="371"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="396"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="462"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="36"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW57262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="504" mass="54477" checksum="808AFF307A6EC5E8" modified="2019-01-16" version="1">MPNSTSDREATVDITEATPLLDNNTGPSDVYSREGLFVIFVCLSLVVCLDIGAGLQVAPSNKILENIICKNYFPDFADIDDQRCKNNDVQGTLAVLRGWQFVTQIIPGLLTTLIYGFLADKYGRRIILFISLVGIILNFAAFAVICWFADIFSVWLTLATPLVMMMGGGSVVATSLVFTIVADVAPESQRATTLFILGAGSLVGDLVAAPMSSILMERNVWIPIILGILIMIIGSLGIFLLPETLNFKTLGKIPDDLETTQSATRDDSESTLLSRIKTTGSQFATAVISYIWGDANVALLMLTLLFTSLGNYARELLLQYSTKKFHWTWAQAGYLLSLRAICSLVLLSVIVPVAGQILISKYSLTAKAKDFWIARTSILMGAFGAFIIAFSASSPFMVLGIIVFSAGGVYNLATHSLMASMVEPHHIGILFNCSALLQTLGSILAGPLLASSFKLGLRMGGIWTSLPFLIAGCLFSCGAMIVWSIDIAVKKEEMREEDPLASSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q652</accession>
    <name>A0A3D8Q652_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">S-adenosyl-L-methionine-dependent methyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_12753</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q652"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF102">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW57303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="41174" checksum="2FCED370FB28BF82" modified="2019-01-16" version="1">MTAPIQGNQLEATPYDSDNDSAFFSSADDGLSLSTSLKSSILDYRMENGRTYHRYKDGQYAYPNDELEKDRLDLQHHIYKLMLDGRLYLSPVDKNLQNALDIGTGTGIWAIEFAEDHPSAVVVGTDLSPIQPTFVPPNLSFLIDDASEPWVFKQKFDFIHTRQLHCVVEEKRLMQQALDNLIPGGWFEMQELALPYGNDDNTNDPNSPASQWCQYMLEASRLIGKPLDNPPNYAKWMTETGFVNVQSVLYKWPTNPWPKGKNEKVLGLWNMVNTLDGLDGFTMAMFTRILKWKPEEVTALLAGVRADTKNHAIHNYCPVYVPLCSLLLLQQSSYKTKTLTLLATSHMGKSRNKPNNAMLLVKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q994</accession>
    <name>A0A3D8Q994_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Nuclease PA3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_12326</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclease type I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q994"/>
    <dbReference type="OrthoDB" id="441446at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11010">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="entry name" value="P1 Nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003154">
        <property type="entry name" value="S1/P1nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146:SF26">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02265">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="Phospholipase C/P1 nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017614136" description="Nuclease PA3" evidence="8">
        <location>
            <begin position="19"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW58396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="331" mass="35495" checksum="2AC48A0005D165A5" modified="2019-01-16" version="1">MATKIFILSLATLPSAQAWGVLGHATVAYIAQNYVSDATATWAQGLLGDTSTSYLASVASWADTYRATTAGKFSAPFHFIDAEDNPPTSCNVDYARDCGSTGCSISAIANYTQRVGDGRLSAANTAEALKFLVHFLGDITQPLHDEAYEVGGNNIDVTFQGYTDNLHADWDTYMPEVKAGSTSLANAQTWANALIAEIDSGSYKSLAASWIAGDTVDDVVTTATKWASDANAYVCTVVMPAGVTALQTGDLYPTYYDSAIPTIEMQIAKGGYRLANWLDMIYTASVAKRSLPIRETLESRRDGYDFLPAPRPMSPAKLAREAAGYDCGHKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q9Z2</accession>
    <name>A0A3D8Q9Z2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_12204</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q9Z2"/>
    <dbReference type="OrthoDB" id="48317at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016651">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08249">
        <property type="entry name" value="enoyl_reductase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047122">
        <property type="entry name" value="Trans-enoyl_RdTase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348">
        <property type="entry name" value="HYPOTHETICAL OXIDOREDUCTASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45348:SF2">
        <property type="entry name" value="ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE PROTEIN C2E1P3.01"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="3">
        <location>
            <begin position="26"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW58274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="343" mass="36428" checksum="E5FDC7D31034385B" modified="2019-01-16" version="1">MAPTFPDGKAAWAVAEKQVPLEVGPGLSEYKPEANELVIKVHYAAVNPTDYIMQDNPYMKFEYPWIFGVDVAGEIFQLGSAVTRFKIGQRVIGHCDSILTNLITHAGFQSYTICREILVAEVPNELPLANAAVLPLSVSTAASALFIGQNLALPSLDPKPTGKTVVIWGGSSSCGSSAIQMAVAAGYKVVSTASSSNAEYVKSLGATFVFDHKDPNVVSDILKLFETETIGGIVDCVALDTTQRACAEILSKLGGGKLSQLGWPIEGAPENVTIEGVNGLDPGLVRLDIGDAIWRKFLPHALAAGKFQAKPDPFVLEGLENVQTGIDLVRKGVSAKKIVIHVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QB53</accession>
    <name>A0A3D8QB53_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_11999</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QB53"/>
    <dbReference type="OrthoDB" id="3344043at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW59075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="377" mass="42209" checksum="7F787A5D7D0502CA" modified="2019-01-16" version="1">MAQYKRRNLSEAQKKEPNEATEDILFTALAVTLPVLTLAAILIWIVFRYQINQDVKASKYGFPSVDNGISGNAYYVDFNTTSFTTVASWASSVATLLPGFIMTLYSYKVAEQVKRDTDLQNNGRLPTPYQFHLWLQMSSGGVWAAWKGIRYAMSMPRERLVRVVTSVLVVSLLIGYSIWVTDTWLHVATTTVAFNQASDIQQSARNYGRMLPARCLTEEVSRNCTIDYVLSRGDYLNEPVEMYYTLGNLSTTNRVLATEVDGNRFSYLAPATLDPSIDYQAASLAVQSSCSLITTLCYKNIATESQQFNCSPGFYNGTSGLYTNDQGQNRTSGFAVGWFQDPQWTKTMDFSATSNPFYTLFRISVGQNPNDESAIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QB94</accession>
    <name>A0A3D8QB94_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Transcription factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_12036</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QB94"/>
    <dbReference type="OrthoDB" id="2593732at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF16">
        <property type="entry name" value="TRANSCRIPTION FACTOR DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW59112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="459" mass="52647" checksum="79A8D4C0C2302599" modified="2019-01-16" version="1">MLKITPEEQRYFEWFHHCSMTKLPGVFDSRFWSTLVLQASSKEPAVLHAVLALGAVHRREVLDVERPRGRRDVFDKQEQFMLRQYSKAISGLQPHFVAQNKESWRVTLIACLIFVFFEYLRGHYQAGGIHLQNGLRLADHCKSILKLSDDPIDKSIMEAFVRLQLQVQMFGQITEHIHSVSQGSHLYCPTIKFCTLSEARQQLDCLLQRSIDLTHLYHQTAVYSGDSPSPELLKAQSQIRVQLGDWFQTLKASEMDLDVHTDARAHFPYRFLSLYHTMAHIMVETCLDTARESIYDNFTTNFVSIITQAVDIYKILISTPADLFPSHSTADIGWIPPLYYTALKCRVHRIRVHAVKILSSSSHKEGIWDSKLAESVVREAIEIEEGEFYQDCRIDDDFPISEVPEAHDLTLPVLPDCYRTSDVTVVLPNNPSEKVELVCRRQGGDGNWESISRRLDASL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QBA4</accession>
    <name>A0A3D8QBA4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidase A1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_12047</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QBA4"/>
    <dbReference type="OrthoDB" id="4074350at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="446"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="3">
        <location>
            <begin position="58"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW59123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="566" mass="61626" checksum="A9DE200F3223BE34" modified="2019-01-16" version="1">MRNFHCVGWGILITASCCDMKVIEPLSSQKGIEKKDVVPEPIVVPPSQYFEGIDGSWSTFIVRIGSPAQSAKVLASTNSPDTLVVRPEGCLEGAIPEGVPSNCASARGGTFNSSLSTSWSAQGWYGLNGIQYGFEANLGYQFNLDYGVDRLGLGFEDGDAPVLENQTIAGGLFGLGTQPVIYSTFGNFSAPSYFVTLRNQSLIPSLSWSYTAGASYRCNAGQFAQLIFGGYDTSRYQPNDVSFQLSADVSRDIVVAIQSISYSGENVLDLLPTPIYAFIESTDPNIWLPLSACLLFEQAFGLQYDNITEKYLMNNTQFTTLWATNPSVSFRLASSTTGGSTTDITLPFYAFGLKAAYPFVPNATYYFPLKRAENTTQYTLGRAFLQEAYLTVDYDRGNFSVSQCTWVDGAKSAVNSILSPLYSTNSTNGTLTTSPKATNEIAIGPIIGGVLGGIVVLMGICAALFWYCWRKQARETKSPQGDSTPHVTLEELKHSDADKIFCTDTESVAGSRNRRAPPSMDTLHSRYEADGLQIYQLSAERSTSELGDTDSYIRYELESTSPVIII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QBE8</accession>
    <name>A0A3D8QBE8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_12096</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QBE8"/>
    <dbReference type="OrthoDB" id="5429740at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF155">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="24"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW59172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="201" mass="22455" checksum="00BEE084B86CA31E" modified="2019-01-16" version="1">MAFLQRLLNHGRMTTILFWGLALSSQACVLATSLWWFVHSFLDIFFALYPIPLVLRLNMPLRSRIAVSISLSLSSLACIVSVYKLVIFEEIFNVLAEDPTYPVPYFNIFGIAEGCILIICGSLPSLGPLFRRARGRLTSRDWSKSGDWGRSTPFQAGEKIDDNLGRTGDSAWVIKLEDPERGSTGVRSPVDESPITPNFKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QBI9</accession>
    <name>A0A3D8QBI9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SnoaL-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_12137</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QBI9"/>
    <dbReference type="OrthoDB" id="3758478at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW59213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="158" mass="17876" checksum="1F4837ACEA73AAC3" modified="2019-01-16" version="1">MSNLAQAIQKTTEAFLKGYVDAAQAKNPGILSAQATDDCVRYIGPPCFLRSVGAPADLFMTNAQYEADFNKMEFYTFDTHEFYDLTIDAPNRKAAVRSELTGKFIDGKELLRTFVWFLEFTEDGSKIVKIYQHNDSEEGRNFRLTVSAYQEAKDRSGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QE40</accession>
    <name>A0A3D8QE40_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Sugar phosphate phosphatase</fullName>
            <ecNumber evidence="7">3.1.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_11719</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate</text>
            <dbReference type="Rhea" id="RHEA:35603"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:138881"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>beta-D-fructose 6-phosphate = dihydroxyacetone + D-glyceraldehyde 3-phosphate</text>
            <dbReference type="Rhea" id="RHEA:28002"/>
            <dbReference type="ChEBI" id="CHEBI:16016"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Ni(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:49786"/>
        </cofactor>
    </comment>
    <comment type="domain">
        <text evidence="7">Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.-" evidence="7"/>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QE40"/>
    <dbReference type="OrthoDB" id="541375at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097023">
        <property type="term" value="F:fructose 6-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0103026">
        <property type="term" value="F:fructose-1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10880">
        <property type="entry name" value="Uncharacterised protein PF01937, DUF89, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036075">
        <property type="entry name" value="ARMT-1-like_metal-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039763">
        <property type="entry name" value="ARMT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002791">
        <property type="entry name" value="ARMT1-like_metal-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12260:SF6">
        <property type="entry name" value="DAMAGE-CONTROL PHOSPHATASE ARMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01937">
        <property type="entry name" value="ARMT1-like_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111321">
        <property type="entry name" value="AF1104-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0464">Manganese</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Damage-control phosphatase ARMT1-like metal-binding" evidence="8">
        <location>
            <begin position="23"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048809"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW60113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="461" mass="51790" checksum="746EA2B99247207D" modified="2019-01-16" version="1">MEFDTKTRPSYTSDKTSFAYISARDRWPVILTGAIDDVHRAVSESTDEEKRTEGKRIVEDLAKLNPLPDDGKPDIASYNKELEQLGSPSWFNIPWLYAECYLYRRIATAFALSSHWKQYDIFARQKMSTFRSSRPAVLELAGRYHELIKQMENKGNKSQEELDAAEKILFMEMCEICLWGNATDLSLLTSLTYEDIQKLQGSEARKASEKNIIANDLEAAYSTLKKAKSEGKKYRQVDIVLDNAGFELYVDLILAGFLLSSGLATNIILHPKAIPWFVSDVVPRDFADLLNALANPQPFYSTPSEDEVAAGKTPTPLSQQEMDELAFLFKTWSEFHSEGQLMLRTSTFWTEGGSYWRLPSSAPKLYEDLKESEIVIFKGDLNYRKLTGDGTWDPTTPFTTAIGPLGPGSGVNVLALRTCKADVVVGLKPGLDEELKGEDKSGKREWAWSGKWAVCSFSDGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QE50</accession>
    <name>A0A3D8QE50_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_11705</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QE50"/>
    <dbReference type="OrthoDB" id="5280838at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38119:SF1">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38119">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="439"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="536"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="555"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW60099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1012" mass="112134" checksum="B4F1E71920A6B259" modified="2019-01-16" version="1">MLSAMKDGASSPRSVEVLPLNDEQESPSKEVETTSNALKIDCTSKYTLPPYAPGDGLVKDSHDALASTTTTICGTESPERERANQSRIESQLIKLHSPSHEVTRDTELPGCMSPHDRKESNIFHHVSKNGNASDSKTPDEDPDTSSLSDAPYDIDIASVDLLQSSGSDPLVFSAAKIPSAEELLNPRDTEILEPQSQTSPTCFESMPTQKEQLKGAETSEDSQSQQHGGAATSVSIPVDISNGGDVVITDPTTDGSAPGYNSSIIKGPLSEEVAVAAADDNRLASIEEAPAPVLAIESPRTVDFSKEDEEMNDASIEEVHTSYMTMTTPTQREIKFSNSEDDVDCGPNILASEIDHGNMFSLVSTADTRDMLNSEIEGSIFLRTPKEPKEVYIHTGQLTQQERTYKQKEPSSFLRSIRTTSILKELANTDGEQNLHLENLASIDDEPGRLPAKKTAGTLGEPPANSDKKRARIAEPPGPSKRQKTREQTVISISDDNSNLSSLEDLDHVSEISTINVDKSKGTAADAYSYTLKLQSKNAPREVRDVKQQEKSRGGSRSLSAVKQNTPLSRNIRNSPVKNGAATSSGAFKQKFHDDATYKIMKKNTGDFPRYAKGENGDVYIEIAYKDLKYSYSIDRAVLEKSSAWFNETINDQIEEYDEELAKEIVASTGKIARYELKWFPEVETWELRRTSFTTPRVNTPTVPVYPPDTVPHCSGVPLILCRAFDNFFRIVCELPPKVDTSNLDGALEELETLSRVASKYGHIQQINVGFLPILKPLGQPLFEAVLRNPVGWLTLSLTLRIKILFVEAIIHVVGLWPHWPSQTMPFNKLPRSVRDLIISKSEKLRLLKAGVDEQLFMASFRFEGSVHDLCLDPEDKDGFDAWFVVQLWRDWLARSLKTYYQESGKYHGIGSIYRQIRRGGDSYLSLSSVLSILDAYRGPDFAEWDPKIVENALNDMKRDAQKFVRKLVVNNCYLNPEHHNISHLTCTTVSDAELPWTIRPPALVSGPTAEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QEP4</accession>
    <name>A0A3D8QEP4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_11928</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QEP4"/>
    <dbReference type="OrthoDB" id="3469466at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="101"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW60322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="124" mass="13997" checksum="3D76D9727CCE8DC1" modified="2019-01-16" version="1">MLTARKRNGSKTNREVIISSHPVRVMALAATSMLNKFVQGYARREYRRSERKKQAQEYTETRRRCKDIYKSPSSATRPLSQDGPGIAGIDLLQRKCSWNRAASQWPEKDPGVSSAKQQVTAGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QES8</accession>
    <name>A0A3D8QES8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_11919</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QES8"/>
    <dbReference type="OrthoDB" id="268400at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF139">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="66"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="136"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="225"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="368"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="474"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="505"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW60313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="550" mass="59971" checksum="37D959F1108D7939" modified="2019-01-16" version="1">MATNDISQKEIIAHYEATSLKDMAGASHRLAGDALLVTVQGEICRLPVPSNDPNDPLNFTRWEKAAIIVACCWFSIMSLALSGGLGAILSTFFQIYLPQGHSTEEIVRLLTFPALFIGVGNYIILPMSLAFGRRPVFILSVVILLAATIGSAVQNSYEAHLATRIIQGLATGATESLLPLMLTDITFLHERSKIFGFYWATQNIFSSGLNIASSYETSINWRLYYWVYVAAIGLGLLLVIFGAFETRFARPLSSLSGQVVYTDNYGVTRILSDEEAQAHLPTSPAITTYSSAPPKKTYSQMLRPWSGSAPRPARLIIMSWIHMAESFTSPGILYAVLLSSITLGCTIGISLTYNTVLENNYGWPAENVGLINIGGIIGGIVGMLYGGWPADRLVIYLAKRNHGIHKPEHRLIMLILPGFLGVGSLLLYGFTASGGSTWWGPYIGWTLFQVVFVTVLIVSTTFAAEAWPKNPGPAIVVVVGSKNLISFGASYGITPMVTEHGYPWALGVLAAIFGAIFLLGVPVYFWNPKWRAYVARKEEEHRELGVGTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QHZ0</accession>
    <name>A0A3D8QHZ0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">diacylglycerol cholinephosphotransferase</fullName>
            <ecNumber evidence="9">2.7.8.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_11223</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>CDP-N,N-dimethylethanolamine + a 1,2-diacyl-sn-glycerol = a 1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33775"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:64572"/>
            <dbReference type="ChEBI" id="CHEBI:65117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:33776"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="8">Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 2/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.2" evidence="9"/>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QHZ0"/>
    <dbReference type="OrthoDB" id="196717at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004142">
        <property type="term" value="F:diacylglycerol cholinephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1760:FF:000012">
        <property type="entry name" value="sn-1,2-diacylglycerol cholinephosphotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF37">
        <property type="entry name" value="BB IN A BOXCAR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015665">
        <property type="entry name" value="CHOPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="50"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="293"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="323"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="356"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00051857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW61331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="409" mass="46027" checksum="2BBC2A3F17AE468D" modified="2019-01-16" version="1">MVYVRQEKLPNLKQYKYSGVDHSLVSRYILKPFYTNFVIKCFPMSMAPNLITLTGFSFVVVNLLTLLWYNPSLDQDCPPWVYISWAVGLFLYQTFDAVDGSQARRTHQSGPLGELFDHGVDAVNTSLECLIFAASQNLGMGWKTVMTLFGSLLTFYVQTWDEYHTKTLTLGVVSGPVEGILILVAVYAFTGIKGGASFWQQSMFRTVGIPHLAIIPDILYEMPFNEWYMVQGGFVLVLNTIQSCQNVIKARRARGDKSRGALLGLIPFFVTWTLIPAYLYLQPNILHNHLVPFVFYAGLVNAYSVGQIITAHLVLLDFPYYNVLVLPLAYAVFDSLGPFLQAHIGVGWPSALGDDIYQVAYMFCMLGMAIGVYGSFVIDVIVTICDHLDIWCLTIKHPWNEEEEAKKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QI55</accession>
    <name>A0A3D8QI55_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Jacalin-type lectin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_11351</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QI55"/>
    <dbReference type="OrthoDB" id="74460at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053002">
        <property type="entry name" value="Metalloproteinase_M10B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021917">
        <property type="entry name" value="Unchr_Zn-peptidase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054:SF2">
        <property type="entry name" value="MIP04191P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21054">
        <property type="entry name" value="ZINC METALLOPROTEINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12044">
        <property type="entry name" value="Metallopep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="731"/>
            <end position="745"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW61459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="745" mass="82293" checksum="E3AFF695AA678C10" modified="2019-01-16" version="1">MVAVQVPKTSSRHLVLSNISEGETVYQRCLLIAGNCPSKSDEDFVAVATPDFPEQLWPISGGRFKCLVILSPGTNKITFESHQNGKTVDNWTLTITYIPLLQTPPLHLAIMIAKDSPLLIDCPPHKRGAISSTHSDLNAAINKFRMTAYMWQALTAEDLRAKGLERRSFRLDEEWTTETLSRDFIQKSLESSGDHMRSTAKIHLIRTEKTLAELRDAQVAQQNPHASHGDGLHKYFSEALKAHGGVFTSAAHPVVAGLILDSTYSAEQNLILGHAALGASNRQGLSLGMFGSHLTYSWPRFMEEVTSCLLDTAMPGDTVGNDNGECGTMWETCSIGQGAFLHEVGHAFGAPHTTGIMDRGYAQDWPKNFLTKTAYCSHTQMAGDYVMDGETKNDASWDLSDALSFRTYPHFKLPSDAFLSKEVSQALPSVQVVYDDDEVEFLRLVIESPAQIVRIKFDNVAEAEPTIGKPATKIQFTRNELEARFDSSKPLALEVLGWNGKSRVFNDIWKLFSKLSVIPVPGTSIVLHKRSIMSESLEAADETTFEENSWNWVVLLNKLGDGGSLIPAVKIDSRVGCVLDGAVVYYKDAHTNPCGPRWDRDGYDHNFGGHASEMIDIPEGTEVVKVEVSSDNHDLNGLRFTLSDGTAGGYIPDEHTSSALEASPDERIVGFFGRSDWGAHFDGIQEFGILTAPRDVEIPLSVYSMPELQNKDGGNGQRGHLKRKRSRIDNGDDSQDDEEVEEMRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QIL8</accession>
    <name>A0A3D8QIL8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative alpha-ketoglutarate-dependent sulfonate dioxygenase-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_11568</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TfdA dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QIL8"/>
    <dbReference type="OrthoDB" id="10257314at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016706">
        <property type="term" value="F:2-oxoglutarate-dependent dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.130.10">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051323">
        <property type="entry name" value="AtsK-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042098">
        <property type="entry name" value="TauD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003819">
        <property type="entry name" value="TauD/TfdA-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT SULFONATE DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30468:SF10">
        <property type="entry name" value="TAUD_TFDA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02668">
        <property type="entry name" value="TauD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TauD/TfdA-like" evidence="8">
        <location>
            <begin position="31"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="334"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005896"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW61676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="358" mass="40159" checksum="C37AC4686CDF023C" modified="2019-01-16" version="1">MAPSATDTETPMATKTSKFLKSTGSLDGFKYDDLTPVIGTEFPELNIVDDLLNSPDADRLIRDLAIKISERGVVFFRAQDNLTNELQKRLIQRLGQLTTRPETHGLHIHPVLNDSREFGGADAEVSAISSAQRSTLYKGTAYDQSAAVWHSDISFEVAPADYSSLRLTQLPKTGGDTLWASGCEMFDRISKPYQKFLESLYATHAGVSFHAMAASKKFEFYTKERGSPLNFGTTLSATHPVIRTNPVTGWKSVFLLGTFPADIHGLTRNESEKLFNWFHELLTYGHDLQCRFHWKNPNDLAIWDNRSNFHTATNDYQGLGDRYGNRVVGVGEKPFFDPESKSRREDLGTMDLMSPAHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QIS3</accession>
    <name>A0A3D8QIS3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_11226</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DIF1/spd1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QIS3"/>
    <dbReference type="OrthoDB" id="4072855at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990846">
        <property type="term" value="F:ribonucleoside-diphosphate reductase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008104">
        <property type="term" value="P:intracellular protein localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013900">
        <property type="entry name" value="RNR_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28081:SF1">
        <property type="entry name" value="DAMAGE-REGULATED IMPORT FACILITATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28081">
        <property type="entry name" value="DAMAGE-REGULATED IMPORT FACILITATOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08591">
        <property type="entry name" value="RNR_inhib"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="83"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW61334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="230" mass="25232" checksum="09CAFB4EC47A29AF" modified="2019-01-16" version="1">MSYHTAKKAYAGTGSQQASITSYFSPSIAGSSPAKAKDTNSISSQELPAHIQSNLISVGMRIRKSVPEGYKTGSDYSAFTLFSDPAAPQTRPGLESRSVSTPSMGRARARELTPWCGILKVGGMAQQMMDEDEDEVPFFSSQESTASNASVVSREGMGSKRRFFEEEEEEEDAEEMQVVMGQRVMAHPRRRKMHSAFKSSALGQENESMDFGEADFLDYSVMEEVDMADS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLX0</accession>
    <name>A0A3D8QLX0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GCS light chain</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Gamma-ECS regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Gamma-glutamylcysteine synthetase regulatory subunit</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">Glutamate--cysteine ligase modifier subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_11125</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterodimer of a catalytic heavy chain and a regulatory light chain.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLX0"/>
    <dbReference type="OrthoDB" id="5596051at2759"/>
    <dbReference type="UniPathway" id="UPA00142">
        <property type="reaction ID" value="UER00209"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017109">
        <property type="term" value="C:glutamate-cysteine ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035226">
        <property type="term" value="F:glutamate-cysteine ligase catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006750">
        <property type="term" value="P:glutathione biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.100:FF:000026">
        <property type="entry name" value="Gamma-cysteine synthetase regulatory subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.100">
        <property type="entry name" value="NADP-dependent oxidoreductase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032963">
        <property type="entry name" value="Gclm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036812">
        <property type="entry name" value="NAD(P)_OxRdtase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023210">
        <property type="entry name" value="NADP_OxRdtase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295">
        <property type="entry name" value="GLUTAMATE CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13295:SF4">
        <property type="entry name" value="GLUTAMATE--CYSTEINE LIGASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00248">
        <property type="entry name" value="Aldo_ket_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51430">
        <property type="entry name" value="NAD(P)-linked oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0317">Glutathione biosynthesis</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NADP-dependent oxidoreductase" evidence="11">
        <location>
            <begin position="91"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="31"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="31"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW62823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="308" mass="34001" checksum="A53F1C7D44599719" modified="2019-01-16" version="1">MTGGPSIIRKPGADRSNLELTNSLRSNFLAAQQDYSPPQATTPKSMTNGDFKETSGEDQLSSRPQVSIWTTRDGSDYYIPTIDWSLSGLAEEPSQYEITVKLFYLPGTAVNDRAQYTKDAVELVLKELGVSSIDLLIVSFPGMSFEGDCEWEADKKNSEQGNDKEEVATWPALEELYKQGIVKKLGLAEFGSEKLNRFLTKVQVRPQVDQINVKDCCNVPPPLVQLAKKENIELLTHNDCTDILPSGTLRELLGQGVRGAGVLSESKRGLHGMKGDIKPNWVAKYTAVVKDRGVVENKGYFAVAELKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQA8</accession>
    <name>A0A3D8QQA8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_10505</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQA8"/>
    <dbReference type="OrthoDB" id="3936451at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF96">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="83"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="8">
        <location>
            <begin position="26"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="312"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="356"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="402"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW64003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="456" mass="49624" checksum="A0DD3EAE432ECD12" modified="2019-01-16" version="1">MGVDRGPELVAVLGVFLGLAWLVVCLRIYVKLFLTKHWGGDDCVLLMSLAFFTAYASCSLSGIEYGTGRHVDDIPPQDAPKALYYWFLCELFYTISTVLVRLSVAIFLLKICISPAHRFIIYGTMTSIILFSIAFFFLILFQCHPVSFFWNQSSGMHGSCINERIVPHASIAHSAISATCDWILGLLPVNLVLHLQINKRTKGSLSIVLALGILAGVAALIRIPYIRVLSISDDFLFKTLDVAIWSTIEAGLGIIAFAATALRPLFRTFYALPHQTHSHENISPFSCSNRSDQTSRLQSYVTEHFRKDSSATATSTIHYGSPQSPSQPFTGAQRQNSIQLRSDISAPQGEVTITSAGTARHGHHIPFSSSKHQRGFTGLGDLDTEWSADDGIQVERTVEVRAGSMSAGGNAGGNAGDREPESFSSLFSSTWTQRGVLGSVSERGRGSLEAARGGSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQE2</accession>
    <name>A0A3D8QQE2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">COP9 signalosome complex subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_10517</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Component of the COP9 signalosome (CSN) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M67A family. CSN6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQE2"/>
    <dbReference type="OrthoDB" id="1378at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008180">
        <property type="term" value="C:COP9 signalosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000338">
        <property type="term" value="P:protein deneddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08063">
        <property type="entry name" value="MPN_CSN6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000055">
        <property type="entry name" value="COP9 signalosome complex subunit 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033859">
        <property type="entry name" value="MPN_CSN6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF8">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0736">Signalosome</keyword>
    <feature type="domain" description="MPN" evidence="9">
        <location>
            <begin position="22"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="218"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="235"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW64015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="406" mass="44144" checksum="488A448CD39AD09D" modified="2019-01-16" version="1">MAAEERNPLLSVQKSSDSGLQVALHPLVLLTISDYITRHTLRQQKGPIVGALLGAQKGREITIEHAFECLLVEIEGEIVLSQAWFEDRLQQMKDVHKVPALDLVGWYTTMPTSGPQAVHVPIHRQILHTYNESAILLGFHPTAVLEGSVGGKLPLTIYESNYETDDSTADSGEDKEMKDGETQLVLRFKELPYSVETGEAEMIGVDFVARGGGNATAIDSSASILPEGSGKGKKKTTEKEETDKAGDRSYLSREDEELIASLTAKANAIKMLHARINLIAVYLQNLPSSFIDHSSAEGTEDDSKKNTPVNFSILRSIQALLSRLTLLIPADAAAFEHELMSEHNDVNLVSLLSSITESVKAVREAGRKFAVVENARSTKHGKSDGRLNWNDGSGSSVMGVGDLMSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQM8</accession>
    <name>A0A3D8QQM8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">mannan endo-1,6-alpha-mannosidase</fullName>
            <ecNumber evidence="4">3.2.1.101</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_10513</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Random hydrolysis of (1-&gt;6)-alpha-D-mannosidic linkages in unbranched (1-&gt;6)-mannans.</text>
            <dbReference type="EC" id="3.2.1.101"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.101" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQM8"/>
    <dbReference type="OrthoDB" id="4187847at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008496">
        <property type="term" value="F:mannan endo-1,6-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009272">
        <property type="term" value="P:fungal-type cell wall biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.20:FF:000006">
        <property type="entry name" value="Mannan endo-1,6-alpha-mannosidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005198">
        <property type="entry name" value="Glyco_hydro_76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014480">
        <property type="entry name" value="Mannan-1_6-alpha_mannosidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12145:SF36">
        <property type="entry name" value="MANNAN ENDO-1,6-ALPHA-MANNOSIDASE DCW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03663">
        <property type="entry name" value="Glyco_hydro_76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 12" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017828143" description="mannan endo-1,6-alpha-mannosidase" evidence="12">
        <location>
            <begin position="22"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="434"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="544"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="573"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="593"/>
            <end position="622"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW64011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="640" mass="70117" checksum="FE6B3809B8F949CA" modified="2019-01-16" version="1">MASRLLSCAWIWLLLVRLTVGIQLDLGSTDSIKKAASDVAWGLVSYYKGNESGQIPGLLPGPYYWWEAGAMMGSMVDYWHYTGDATYNSLVSQALQFQVGADSDYMPANESASLGNDDQAFWGMAAMSAAETNFPNPPAGHPSWLALAQAVFNEQSGRWDTSTCGGGIRWQIYMITGYNLKNTIANGCLFNIASRLARYTGDDKYAQWAVKLWDWLEAVHLIDNAYNVYDNAEASNLNCTEVDHHQWSYNTGTLLLGAATMYNYTNGSEVWYNRTLGLLTRTAEVFLPDGVMQELCEESNGCNVDQHSFKAYLSRWMAATTQMAPFTYNTIVGLLRSSAVAAAAQCTGTVPGISVPAGQVCGLKWYLNGTWDGSNGVGQQMAAMEVILGTLINQVAAPLTNSTGGTSIGNPTAGRNTTATPDILNFASSRSSKIGGWFLTAFILISTVWTIWFMATTSWEHEGINGPTVNGMYKRERRNRPISALEKGKGRESFIPKRDSALVVLPGIDEEKPVALESIHEMSRTTSNRLQAISFIDDDLIQQGSPREIGESGPYASIPHDDDFVDDGTQDEAAVREDFPHEDTPRPASIDGNRSHNEVEGDKLLQEDSQDKVDDVPYHDIPLEEAPLKSTVAKDLSDET</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQP1</accession>
    <name>A0A3D8QQP1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_10635</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQP1"/>
    <dbReference type="OrthoDB" id="4151048at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052783">
        <property type="entry name" value="Metabolic/Drug-Res_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655">
        <property type="entry name" value="QUINIC ACID UTILIZATION ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47655:SF3">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="53"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="206"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW64133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="398" mass="43636" checksum="B69CC82C84EEA7BA" modified="2019-01-16" version="1">MSGLPTPPMEDHPTRRTKVSSSKSAHRSSKRASTTHDHGAVIIDGRHKRVWKACERCRMKKTKCDGESPCKRCKDDGLVCTAGSRKKTEFKQLPRGYAEVLENTQYALIATVQKLYTMIRNGESWELGEPEMNERGQPVIHDIASKLGCIRPSPDLPCAFPEGAEDFAELQAQLQAARAEMSAHDIGGSNGSRKGSDSAVSSPPLDRTDRASSSESDHSNISKDYNQLLWQQQQQAAAAKNNVSPLNPMVLKSEPNAGVRQSFDEESVYQSRASFETSQSMPSPVFTEFRSSSPMFRNASPFSPWSGGDEFLGQAHALDLTAHYMRQQQYGAAPRSAPMAGSFTGAMDSDMLKSMQINDGMFADGTIRPGMLDCSTGPSLDQLDNMMFGTDYDNGMLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQV0</accession>
    <name>A0A3D8QQV0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_10695</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQV0"/>
    <dbReference type="OrthoDB" id="3641074at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017634462" evidence="2">
        <location>
            <begin position="19"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW64193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="137" mass="14744" checksum="4A69DDD078390984" modified="2019-01-16" version="1">MKVTQVFSVLLVAATVSAVAIPAPEAHCGRLGQPCKREAVAEVTADEIVKREPGPIPEPEPRCGRMGQPCKREAAPEPVPEPEPRCGRMGQPCKREPGPIPEPEPRCGRMGQPCKREAAPEPVPEPEPRCGRMGQPC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QRC1</accession>
    <name>A0A3D8QRC1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glycosyl transferase family 25 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_10546</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycosyltransferase 25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QRC1"/>
    <dbReference type="OrthoDB" id="47375at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06532">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050757">
        <property type="entry name" value="Collagen_mod_GT25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002654">
        <property type="entry name" value="Glyco_trans_25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730:SF53">
        <property type="entry name" value="GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10730">
        <property type="entry name" value="PROCOLLAGEN-LYSINE,2-OXOGLUTARATE 5-DIOXYGENASE/GLYCOSYLTRANSFERASE 25 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01755">
        <property type="entry name" value="Glyco_transf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 25" evidence="5">
        <location>
            <begin position="73"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW64044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="399" mass="44336" checksum="47D3641C2C1B1B74" modified="2019-01-16" version="1">MAILSVTVNPTRKIMKPSKPHFIGAVAAALLFIVLVFSHGSLPGGRFEGYRGTTEGVANNTLMHVMNETLGFQQIFVMALPERSDRRDAMSLQASFTGIKFKWIQGVKGETVPEKAVPPAWPIAADKKGVLGSWRGHMNIIQKVAKDNIQSALIMEDDADWDVMLKSQLLEFARGTRYLQHAQQDSVSPYGDDWDILWLGICKSKNDDGKDQQYYIINKDPTVVPAELRTATGRLPSLPPQVLTDKYTRVIYEPYGGGCTYGYAVSLRGARALLYSQGLTTEGTTMDKALKRLCKKSTFNTRCFAPYPALIGTHKPAGDSSRDSDREESAGAIREKAVTQNIVYSTRLNLENMVRQKAIESQYPEDTLFPSYNDSIEIPQGYGTMVSKEQFAMQDKLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QTQ5</accession>
    <name>A0A3D8QTQ5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09857</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QTQ5"/>
    <dbReference type="OrthoDB" id="3564743at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW65165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="628" mass="68673" checksum="4CB554A7849E7AD2" modified="2019-01-16" version="1">MTDPSVVRGDSSDDEEAEIGSRSSTSSSFGPETYDHVAGGPFLAPSLSPWSTALSTSTGWLSLSTRSEIWVSSTEPSTAASRHLGSLPNSPSPTTPNRPHLDQSTSSLRDDHRHHPYSQWRTPSRSTSDSSSSSDVDEAWGRSVGSQVFVSRGIQPLDTPDTSEADSEEADPHVDEENIGGEVVGQPQPVELTGLEFPGHLRSLDFAAAAHIDIDIDVHQDQHGIALERHAQPWTPWRGSSMPNSNASASAPAPGYVYNTIYSSLSSGVSQLSRRLTQTPEPRRRAISSFHPGFLVAHLQQHRTASFASQIHAPEDIFYNTEYQVSFNLGLGPPVPIKVSPFIPRNQTDLRSFQKQVGKEELDVQDSLPISLHFFAVHSMAEKLNVWLDAMISSASDLSAYVKLVMDSQEVGAGAKALYSIVSWFTECKSQLSEKEQDTIRNAFKILITTTLLSLIPRLTNIPSPLQEHLSQTMPGCNTSISKLSPDAPKLLTRQIKSGFYHLQMQLLDPLFSQLERESDLVPDVRLATTILIAIALDMVRDAGRVFAKYASKINPEVVVTERHVGDYEEAVQISVLPQLQASVLYYGADGRKGTLGEILRNLETATIGTTKTKRSVQCVLELLDAGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QU10</accession>
    <name>A0A3D8QU10_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_09944</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QU10"/>
    <dbReference type="OrthoDB" id="508119at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000026">
        <property type="entry name" value="MFS quinate transporter QutD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF23">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="117"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="189"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="341"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="445"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="14"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="505"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW65252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="524" mass="57341" checksum="C23D50F5C7644026" modified="2019-01-16" version="1">MANGFFKNRRVYLLTSVAYMGSLLFGFDTGVMGSVLALTSFKKDFGLPTDKSGFSNSRNAQVSSNVVSLLTAGCFFGAIAAAFLNERYGRRFSLMGFALIFLVGAAIQTSATHAIGQIYAGRVIAGLGIGGMSSITPVFVAENCPPAVRGRITGLFQEFLVIGSTFAYWLDYGVALHIAPSTKQWRVPVAIQLIPGGFLFIGLFFLKESPRWLMKQGRYEEATESLAFTRCEAIDHPEVVREIAEIRAAIEEELSATEGVRWKECLTPGNRYRFITAFILMLCQQFSGTNSIGYYAPQIFQTIGISKTNSSLFATGIYGTVKVVATGIFLLIGIDKLGRRWSLVLGAAWMMSMMFILGAVLHTHPPTNVNTVSPASIGMVVMIYLYVIGYSASWGPIPWVYLSEIFPTRLRSYGVGLGAATQWLFNFCITEITPNAINAIGWRTFLMFGIFCAANGTFVFFFIKETKGRSLEDMDILFGTVNAEQRAADIENVLHAKEEFTHEEDAGAVAPTNEKTATTTTAVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QU13</accession>
    <name>A0A3D8QU13_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidoligase enzyme-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09957</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QU13"/>
    <dbReference type="OrthoDB" id="412402at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022025">
        <property type="entry name" value="Amidoligase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847:SF1">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12224">
        <property type="entry name" value="Amidoligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="26"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW65265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="373" mass="42281" checksum="AF440240771FF699" modified="2019-01-16" version="1">MAPNSSPLRRRLTFGIELEFALATVPIGKPDPHPEDPRQVYFHDPSNPANPPSTTSTFIYTILTHVAQTLTQHHVPAIPILKRSQTTTFSRNWLVKTDASIQPPNPTSALYPHAYRWYAVEVVSPAYYHSPSTTDACRKVIRILREQYRMVVNESCGLHVHVGNGLDGLDGKWLRNLMGVLWTFEAQLESLFPAHRKPRPGQGAEFNFALSCASVLARQAEDQTVGEGSSLAWMITQQKREWGLEQILARRDVAELCGIMASQYGPAIKCLPYHIQGLNPRDTSAGVEGSKKTIEFRQHQGTMDEEAVVMWVETVVLIVEFARDVEEERLMEWLREYIKLDERQFGVVRFLLAIGASLQARYYGREIGVRREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QXU9</accession>
    <name>A0A3D8QXU9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Xylanolytic transcriptional activator regulatory domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_09371</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QXU9"/>
    <dbReference type="OrthoDB" id="2283488at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000435">
        <property type="term" value="P:positive regulation of transcription from RNA polymerase II promoter by galactose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051127">
        <property type="entry name" value="Fungal_SecMet_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424">
        <property type="entry name" value="REGULATORY PROTEIN GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47424:SF12">
        <property type="entry name" value="TRANSCRIPTION FACTOR ASQA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="4">
        <location>
            <begin position="251"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW66622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="575" mass="65022" checksum="726642F2D862E07A" modified="2019-01-16" version="1">MFATLLEYYTNCIDESSASFACRSDDTPPSESLASTQSILFGSISTEPTEVHTEVHETRWKGFTIIDPLTNSTIHYGPSSILTFVERIVACLHSEGHKHISASSINPKPESATSVLSSGNIPKFSGFPRRQEELFIQLFWQTYHGIVPAICEKDFREHFDSLWLGSTSKVERDSSPLVDIVLAICIKYGRSFTQAPCLHYDVSDTIFASVAYFRRCQIALMDQWESPTLMTVQCYAFVVFYLHEAAWTNMAYAALGTAVGLAKTIGLHLEPPNHLSRQERELRKRIWWLLYIMDTRISIELSRPWAISEIYISLPAQDQELSQLEFPELSASSEHITCLDSHVQEIRLFQATRIVYTSFYSGINDTFPSDNKNIYEGMAHLELFAGRLAKCMEPLHNWVRDLPEGLKNKRANGGRPLSADRTLVIKDVTAPQWLERQRVTLELLYHNTVIAFHRQFISFSPPSSITPLANMHALAALNHSITVTYLVQAIQVDFNIFSTLFEACKVLWQASLTMLAYTLPYPLSPETKATHAAIACAVLVFDVWSSHCPAAVRCAAVLRDLEPIFKWRLRNVLAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QY28</accession>
    <name>A0A3D8QY28_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Superoxide dismutase [Cu-Zn]</fullName>
            <ecNumber evidence="3 10">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_09472</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="10">Binds 1 copper ion per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="10">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the Cu-Zn superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="3 10"/>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QY28"/>
    <dbReference type="OrthoDB" id="2015551at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00305">
        <property type="entry name" value="Cu-Zn_Superoxide_Dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.200:FF:000001">
        <property type="entry name" value="Superoxide dismutase [Cu-Zn]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.200">
        <property type="entry name" value="Superoxide dismutase, copper/zinc binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036423">
        <property type="entry name" value="SOD-like_Cu/Zn_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024134">
        <property type="entry name" value="SOD_Cu/Zn_/chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018152">
        <property type="entry name" value="SOD_Cu/Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001424">
        <property type="entry name" value="SOD_Cu_Zn_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10003">
        <property type="entry name" value="SUPEROXIDE DISMUTASE CU-ZN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00080">
        <property type="entry name" value="Sod_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00068">
        <property type="entry name" value="CUZNDISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49329">
        <property type="entry name" value="Cu,Zn superoxide dismutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00087">
        <property type="entry name" value="SOD_CU_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00332">
        <property type="entry name" value="SOD_CU_ZN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="9 10" id="KW-0186">Copper</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Superoxide dismutase copper/zinc binding" evidence="11">
        <location>
            <begin position="14"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00020928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW66723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="154" mass="15808" checksum="D3B8BF47A5E68AE6" modified="2019-01-16" version="1">MVKAVATIRGDSKITGTVTFEQASESSPTTISWNLTGHDANAERGMHIHQFGDNTNGCTSAGPHFNPHGKTHGAPEDEVRHVGDLGNIKTDGQGNGVGSTTDKLIKLIGPESVIGRTVVVHSGTDDLGKGANEESKKTGNAGTRPACGVIGIAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QY83</accession>
    <name>A0A3D8QY83_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Glycosyltransferase family 2 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_09505</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QY83"/>
    <dbReference type="OrthoDB" id="2849215at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052427">
        <property type="entry name" value="Glycosyltrans_GT2/GT47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844:SF1">
        <property type="entry name" value="EXOSTOSIN-LIKE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47844">
        <property type="entry name" value="SYNTHASE CPS1, PUTATIVE (AFU_ORTHOLOGUE AFUA_7G02500)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13641">
        <property type="entry name" value="Glyco_tranf_2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="45"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="83"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="506"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW66756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="555" mass="63092" checksum="A668D9BE83D15E2B" modified="2019-01-16" version="1">MSNHFSTSQLTDTQAGSSIEEVRPNEYTIRAPFNLFLNTQTVNRLLRTYLLVAITYTAIAYFRQAIAGALNIISRTSAKTANVVTLTVFTVLTWQPTIILAAFFLAFVPVVNEFFQHTLPDFFWAQPWVFVFWVLIIFKFSKVVIHLISYITYRPVPLPAHPTLSGSDVSVIIPTVGDVSETQFHHEFEECLKTILLNRPLEIIISTVGDQKRQQLVAFCHEALQRFRAEPDFADVNTTIRVISIDIPDKRQQLLAGVQLVGTRITAYADDHVYWPRTFLEHTLAAFEDDLVGLVGTVKRVRRERGNTLLDSLMNYLALMYLERHNYECTATNNIDGGVFVISGRTAMTRTRIIQSAAFRNGFTSETWLGAGPMKVDDDNFITRFMVNHGYKTVFQNCSEARMETVLGVSGPRKLQGQMIRWARTTVRSNAVSLLIDRTCWRAHPWTTWGMFITSYLNNALIYDSLLFYTFKKSDVSISLLYLVAAVYGSKLIKPFGHLCREPRDVFFILFNVFVFSYLHSLLKIWAFLTPRDIRWTGRKGIDAAGSAAPPAVNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYE6</accession>
    <name>A0A3D8QYE6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Metallo-dependent phosphatase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_09558</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYE6"/>
    <dbReference type="OrthoDB" id="7722975at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07407">
        <property type="entry name" value="MPP_YHR202W_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000043">
        <property type="entry name" value="Ser/Thr protein phosphatase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.780.10:FF:000008">
        <property type="entry name" value="Ser/Thr protein phosphatase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.780.10:FF:000009">
        <property type="entry name" value="Ser/Thr protein phosphatase family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053828">
        <property type="entry name" value="Nucleosidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014485">
        <property type="entry name" value="Pesterase_C1039"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041823">
        <property type="entry name" value="YHR202W_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF43">
        <property type="entry name" value="SER_THR PROTEIN PHOSPHATASE FAMILY (AFU_ORTHOLOGUE AFUA_3G04160)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21953">
        <property type="entry name" value="NadN_nucleosid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017316">
        <property type="entry name" value="Pesterase_C1039"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017748250" evidence="1">
        <location>
            <begin position="24"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="domain" description="Putative 5'-nucleotidase C-terminal" evidence="2">
        <location>
            <begin position="371"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW66809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="608" mass="68436" checksum="A9FFAC4A621E63C5" modified="2019-01-16" version="1">MAGYSRRSLLWLLSSLLPSLTAGAQPSAPSPVAAPMRPLTWGQLNFLQTTDTHGWHAGHLQEPQYSADWGDYISFANRMREKADKEGRDLLLIDTGDRIEGNGLYDASNPKGQYTYDIFGQQDIDIICTGNHELYQADAAAREYTNTVPNFPGKYIASNLDYINPKTGEQIPMAQRYRKFTTKNQGIRVVAFGFLFDFSGNANNTVVQPVEKTIQEQWFQDAIREDTDMFIVIGHVTLHGPEYKALYKAIRGQNWDTPIQFFGGHSHIRDVAKYDANSYGLQAGRYMETIGWASLDGIRIKGKQEFEKISESAGLSFTRRYIDNNLLGYYYHTGLDESSFPTEHGTNVSASIRDARKTLELDHNYGCAPKDFWLNRAPFPSNDSLFTWLQDSVLPELVHLPERKGVPRIALTNTGAMRFDIFKGAFTRDTTYIVSPFISKFVYIKDVPYVSASQLLRLINNGGPVFEAAGLQKSQLTSPEHISIKSDIIPEPEVYNPGPQSPLGDLSTPDLVPGYTTKDELGDDGDDTVHSPLTFYRVPNCIESRIEFPEKTPEKVDLVFIDFITPWVLAALTFTGEKYTKGDVLPYLKDGFTELLAEWIKQNWGQDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYI1</accession>
    <name>A0A3D8QYI1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cytochrome c oxidase assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_09487</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PET191 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYI1"/>
    <dbReference type="OrthoDB" id="282149at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033617">
        <property type="term" value="P:mitochondrial respiratory chain complex IV assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018793">
        <property type="entry name" value="Cyt_c_oxidase_assmbl_Pet191"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28627:SF1">
        <property type="entry name" value="CYTOCHROME C OXIDASE ASSEMBLY FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10203">
        <property type="entry name" value="Pet191_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="74"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW66738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="125" mass="13922" checksum="E78FC42E9672E850" modified="2019-01-16" version="1">MPSSCKDIRAALADCLQNSDCIMVQRNTPADCLRSPLLETMPTKCQQLKKGYGECKRGMVDMRKRFRGNQPIAMSKELEGGSSKSGGQLYAGKPAFESTVKATSGNEPEEPDWREVENEKYRKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QZ27</accession>
    <name>A0A3D8QZ27_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Allantoin permease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_09811</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW67062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QZ27"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF0">
        <property type="entry name" value="PURINE-URACIL PERMEASE NCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="356"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="466"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW67062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="579" mass="63718" checksum="576BF7D29BB1BA92" modified="2019-01-16" version="1">MSEISFSATAAGEVKVPDANLRATSDSDVQGASSEPLDHSRWGWFKASTDAIALPSAASPLINEELLPSPEERWTWSTWDYFAYWWSESWSVSSWSTGSAMVSVGASFRDAILINMTANVLSSVVIILNGRAASKYHVGYPILTRYTFGIYGQYIIVCLRLVLSIIWVHWRSTLLHWTNDFDMSPLHLSQDQHVTTGLMVAFLLAFIAAIPLAMLHTTKIRWVFTVKAVIVPAAAIGLVIWAVTTNHGISADKLIDPSLRTSGPAYTWTAFGHFNSVMGANCALLVTVPDLARYAKTPRSQVFGQALGLPLTATISTALGIICTSAIKNMYGEAYWTLYPLFNAILDHDYSSKARAGVFFCAAAWAFAAIGTCVAANVIPFSADVTNLAPRYINIVRGQFICLFIAWGIVPWQIVNNAAGFLNFLSGYSIFMGPIVGIMIIDYFVIRKGNLEIKDLYTYSPSGRYFYYKGFNLRAFFAFVVGFLLPLPGFGASFGYSISPTATRMYDLGWMISFVVGCLSYWVVSLVWKSAGDDAQLPRESKVQEALHAVIEGIHLDLSVADRTRETQGMPPAKPMELV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R3J8</accession>
    <name>A0A3D8R3J8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Vacuolar import and degradation protein 21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BP5796_09148</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the EAF1 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INSIG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="5364245at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025929">
        <property type="entry name" value="INSIG_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459:SF1">
        <property type="entry name" value="E1A-BINDING PROTEIN P400"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46459">
        <property type="entry name" value="E1A-BINDING PROTEIN P400-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07281">
        <property type="entry name" value="INSIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00573">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="240"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="268"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="HSA" evidence="18">
        <location>
            <begin position="1187"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="17">
        <location>
            <begin position="1454"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="417"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="552"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="658"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="743"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="862"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1591"/>
            <end position="1630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1648"/>
            <end position="1705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1772"/>
            <end position="1856"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1906"/>
            <end position="2001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="552"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="573"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="590"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="664"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="773"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="805"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="823"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="862"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="946"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="993"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1059"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1077"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1614"/>
            <end position="1627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1665"/>
            <end position="1683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="1686"/>
            <end position="1699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1773"/>
            <end position="1809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="15">
        <location>
            <begin position="1815"/>
            <end position="1827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1834"/>
            <end position="1856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1938"/>
            <end position="1983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RDW68491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="2001" mass="220149" checksum="8937E4F7219C08A4" modified="2019-01-16" version="1">MAATSPTIIRPIPRRPFEQNDRPSMPPSPLLSATSIDDLDRPSTSVSRTHSILNLTSSTLLGIYSPTYNTDRDESLTPWGTGAETPISSRPTLYRPPSAARIPALSSPTVVFALASRTVLLFCMGIVYGLLVRHLHDDRQLAPFQVEGILKPSYDRKYLVFWGVAGVALGSLLPWVDARWAEALEESHTPELSWDRRAPSAIENDAESSSGIFGGADWTPVVRSFGAFIGIAFAIRKLPWASTLQASLTLAMVNPVLWYLIDRSTAGLLLSISVGATGTAVVLLAKPDMMPSPASGSRNMMNGTQLFNDLVMGGQEAGFTQERRTGRGQEKLQHLRKATVVLIRRHGVSCNGPALTWDSDPSQAQARFTSGVAPSSQNSLAALPCVTFSKETDWLAPKVKCPGKVALVHSNDQRTCYGRESQQPHGIRKSINTHPNHEFSSTKPIRIISYCSINPTSASVFSKNGCRDRLIMSEVVAADRSRLLRSKRAESSGIVTSRKRKLRELYAVCDNEGPLPTIDLSDPDASPINDNEKQFLDVCDILQDRLFDEARLPPRRQLRSDTLKQQPSSPESKFADSPRKKSQRKDVSKSSKPTSPVTTNNQPLTTEAQDAKAVEGISYDGNAVQRPSSKGLQVTLPAESAAVLNEIVEESFNNVDQQQPLQKISDKTEGALERDRITTSVESRPGSPGVDPRKAVPISAEDAAQLSESLIEGQANHDEHHKAATVHLPSREIQEQRLRDIKAHKASPAQENGRLSICPPSRDIGRTAEPLSSPGSTAHSATTPALHEASTDTSPDNESSRYDVDQVEDGEDEAPETPPELRPTPEEVAQKAEHERIQKAQLEISRAEILRSSPAAIDAQIRQEEQAAAEAAGADEDVRMEDAEDGTLKSDSLTTEAGEVVQDIVKDVKELATAPNSELQPETDPTKQPEVADSEGESPPVDAMEVDNRTVKDSFESHPTPETPAGTEAANEVTESPAHSTKESKEASPLTPAASTPRRTPSVAPPSSSERMTTRVASGAIRHKSVSEILGEIPHPNTGSTSEHSPLIKGNDSESMANSHSLSRSTTPQSSSSRVRSLVDRAKDKERSKLSTVVFAKQPLKRNADTHALVANGRRIPQKEAEDYFLPMWRAKPDSKVVQSVEALLTTSHKTITTSNAYIPIVENQATRVLHRIKYLQEIDKWSLRQPQRSLEPNRPKTHWDVVIQEAKWMRTDFREERKWKMAVSRNLASACAEWIGATEEDRKLLQVKAKLPPRPSDVVNKDIDMTDIASSQAHPTPDLIASIDTDSPMDELDEEPRFSLQDTVAPAAIFGLQDDDVIFGLRRTAGTDKLLEELPLYGAPLEISQIAVPNFEFDPDAAWKRPALSLSKYVEGNMQLKTEGPPRKRSRYDYEDEDDDEDEVVFGELNTTQPHLAPESTEVALFNPENKHIRDRIHAGHQFRPPSEFMMPLQSFFESRTASQWTWQEDDDLKKHVRDYSYNWSLISSMLTSKSMFASGAERRTPWECFERWIHLEGLPADMQKTHYFRAYNTRLEMAQRTLADQAANAPPAQPNAAGQIAPVRRRYTTSIRVERRRNQKHLTLVDAMRKLAKKRETTAQKQQHAAGLAAMRKANEQPQPRAQLHTPQDFSRLKHERELQVQERLARFAAQQEHQRRAQLAAASGARSGQNPQGNQQPALPQQMSRGPMPPNNPNAQPIPNPNQLAVPGQNRARTAMAPNPMAQQVPMQNGLQVPQMHMNSVPQAQMQGMPGRLPNPNPALDINLVTQSARIAEQQRQAVRMQQQGQQQQHPGQQSQPHNSPPNMRSVPNGVNGGPPYIPNPNMMPPFNPNTNGMSTPPANGLNVSTPGSAGSPRVAQTGNQQPIKALEQQIRQKFPNATNEQVQAMIRDHLTRSVAQAQMTQSAMNAAAGGNMNGNGGQPRVPSGVENSPQLYAQMLRAQQAAQQASAAASHANHPQQQQQQQQQQQQPQQQQQSNLQPPQGSQTPGLQPPRAGSASSGVGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7J4</accession>
    <name>A0A3D8R7J4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">gamma-glutamylcyclotransferase</fullName>
            <ecNumber evidence="1">4.3.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_08419</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.3.2.9" evidence="1"/>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7J4"/>
    <dbReference type="OrthoDB" id="2924818at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003839">
        <property type="term" value="F:gamma-glutamylcyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06661">
        <property type="entry name" value="GGCT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017939">
        <property type="entry name" value="G-Glutamylcylcotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013024">
        <property type="entry name" value="GGCT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036568">
        <property type="entry name" value="GGCT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12935:SF0">
        <property type="entry name" value="GAMMA-GLUTAMYLCYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110857">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="37"/>
            <end position="42"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR617939-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW70022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="320" mass="35966" checksum="04EAE29B16A26FB0" modified="2019-01-16" version="1">MPITAPALTQPSPPSAPRISSPAQAAQPEPETEPVLYFAYGSNLAPSYMKTRCPNSAFHSLGYLPDYRWIIREGGFATIFPVETKQKPEVEFKGKGGCLLSHPLDELFPEDEEEVEGEEEIRDVRDAGGIEIGGEEEEEGGEEREGVWGIIYKITPDELFDLDASEDVPRSYAKTAVTVTSFPANPMLSLISNSWHPRAQTSTQVQAYTYTHPIASPSSEREEEEEEEERRVPEGLILHRYIARLNTGIVEAAAYGLPNAYVENVLRRFCPEVVKEEDENVRWVRQGYWKRERYGEEVEFKELRALLKDLGVGEGIGGSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8G3</accession>
    <name>A0A3D8R8G3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Bicarbonate transporter-like transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_08595</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8G3"/>
    <dbReference type="OrthoDB" id="1735926at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080139">
        <property type="term" value="F:borate efflux transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005452">
        <property type="term" value="F:solute:inorganic anion antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050801">
        <property type="term" value="P:monoatomic ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011531">
        <property type="entry name" value="HCO3_transpt-like_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003020">
        <property type="entry name" value="HCO3_transpt_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453">
        <property type="entry name" value="ANION EXCHANGE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11453:SF82">
        <property type="entry name" value="BORON TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00955">
        <property type="entry name" value="HCO3_cotransp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="203"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="242"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="341"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="7">
        <location>
            <begin position="3"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Bicarbonate transporter-like transmembrane" evidence="7">
        <location>
            <begin position="115"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="458"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="475"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="536"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW70198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="547" mass="59930" checksum="C6D8C25FDBD54A52" modified="2019-01-16" version="1">MSYGVNEVLLASVLGSVVFAVFAAQPLVIVGVTGPITVFNYTVYDIMAPSGTNYFAFMCWIGLWSLVMHWILAITNACNALRYVTRFSCDIFGFYVAFIYLQKGIQVLTRQGSGDAFYLSITVSLLVLVVGYLCGVIGGSNLFQHYVRVFVKDYGTPLTVVFFTGFVHIGKMRDVSLNVLPTTDSFFPTTDRGWFIHFWDIRVSEIFIAIPFAILLTILFYFDHNVSSLIAQGTEFPLRKPAGFHWDIFLLGLTTGVAGLLGIPFPNGLIPQAPFHTDALCVTKVVTDPNEEGESKGHVVTKVDHVVEQRVSNLAQGILTLGTMSGPLLVVLHLIPQGVLAGLFFVMGVQALEGNGITLKILFLCKDKKLTSSSDPMRRIQRREAIWIFIAIQLFGFGATFAITQTIAAVGFPIIILLLIPFRTFVLPTWFTQEELSLLDAPTASPFTMISVGGNHGEKIEDDLGSKDQNGFGSGTTTEGPSTSTSQALLGGGEDTIEGLAERGEGPGARMKRRESWRSDGRSGNIVESIEMQKPGMRRRSMSRQSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCP2</accession>
    <name>A0A3D8RCP2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_07722</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RCP2"/>
    <dbReference type="OrthoDB" id="5417844at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF47">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="201"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="29"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW71688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="322" mass="35420" checksum="E32C2B6D6B442CA1" modified="2019-01-16" version="1">MAIVLNHRQIVVIVTSAVLAPLAITAVTLRLIARFRVTRAGSVDDCILFVGLLSVLTCIASVCSQVLFGLGQHLETISPEDLERFFISFWISIISYAISVAATKTSIIFQYFRFLTKPGPRIACWVILFVVNTYGLFAVFATIFMCNPVQGFWRPAIAKSCLTKDAVWITNSSVSIATDLVILCIPVSTIFGLNIPLCRKIPIFCMFGVGIVACMITILRMSSLLMVARDHDITYINAITATWSIAEITAAIICASVPGIKPIFQRRPRQSSASYIRTTQGSTELSAVEHKGHCSRIRQLPEAMPRPLEEVPLGNCIARPHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDV5</accession>
    <name>A0A3D8RDV5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_08194</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDV5"/>
    <dbReference type="OrthoDB" id="10398962at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="145"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW72160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="250" mass="28605" checksum="9D8837A8B40AB7C4" modified="2019-01-16" version="1">MNYYQHAPRPAAEPNATLAQENQRLRKERDQARKLLVAQKERDLAQLRGSLNPPARQQRAATAQRTRQPAAVQHNNKHAADADADLLRENQRLRHERNQARKQLVAQKEKELAQLKGSLDPPARQKVAATAQRTRAPTAVHRPVHKAVETDAATIARENQRLRKERDQARKLLAAQMDENAKVKRPVNPPARQKVTAANQGRVPVHTISHPHVRRDPRDAEIRRLKKERDQTKIKLQIARTEKELAQLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDZ6</accession>
    <name>A0A3D8RDZ6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF7908 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_08145</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="3559145at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057230">
        <property type="entry name" value="DUF7908"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25485">
        <property type="entry name" value="DUF7908"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017735406" description="DUF7908 domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="1822"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7908" evidence="3">
        <location>
            <begin position="108"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW72111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1822" mass="178857" checksum="F3784078178F2EBF" modified="2019-01-16" version="1">MLYESLFTILGVVIGSANSAVLPDELACVNGSLEHIQPFFIEYPVYINTYIAANTIININGGLTININNAPTHLITTLNATSTVNVTSTITSTVTTTATATNTPIPTSQTVIFSFIPGYATGRKRQEYSANYVGAGGNTVDLCSDATVFTIANSHLFDGYQEVSTNPGVARAPFQSSSTIGSISTVFSLIGGRLAWTNGEFTGGAAQFCWLNSSVQIIFNGIIPDGCIIGSLEAITAGSCPGLSTSTTTGKSASTNASSTITSRGTSSLSTSSVVTNITSISQTSATTGSISTTSGGTSTPISSQSTSSSSTTESSSTSPSGTSTPSFTRTFPLSNSTTTSSDTSTSGTVPTSVTSSTSDTTSDTSSTSGTSSTSDTSTSTTLTTTSSDTSTSSISTTSPTTSPTPPACDNTSAVIDPAGSNTCVCTTAGDLPNANGVSCSAPLACDGTTAVLDPAGTNTCVCTNPTVDTINSNGISCSPPCDGTTAVIDTTGSACVCTTPGDSLNANGISCSTPPACDGTTAVIDPAGSNTCVCTNPTIDTINSNGISCSPPCDTTTAVIDPAGSNTCVCTTLGDAPNANGISCSPPPACDGTTATLDTASNACVCNTAGQTLDASGLSCSGTPACDGSSAILDPNGSNTCVCTDPSTSVDSNGISCSAPPACDGSTATLDATNNVCVCNTAGDTLDASGLSCSATPPACDGSTATLDTTNNVCVCNTVGQTLDASGLSCSGTPACDGSTATLDTANNVCVCNTPGDTLNANGISCSTPPACDGSTATLDATNNVCVCNTAGDTLDASGLSCSTPPACDGSTATLETTNNVCVCNTVGQTLDASGLSCSGTPACDGSTATLDTTNNICVCTDPSTSLDSNGISCSAPPACDGSTAILDPNGSNTCVCTDPSTSIDSSGLSCSTPPACDGSTATLDTTNNVCACNTAGDTLNANAISCSPPCDNVSAILDPNGDRISCSAPPACDGSTATLDTTNNVCVCNTAGDTLNTGGLSCSPPCDGSTATLDTTNNACVCVDPNTSINSDRVSCSAPPACDGSTATLDTTNNVCVCNTAGDTLNTGGISCSPPCDGSTATLDTTSNACVCVDPNTSINSDRVSCSAPPACDGSTATLDTTNNVCVCNTAGDTLNTGGLSCSPPCDGSTATLDTTSNTCVCTDPTTTIDSSGTSCSAPPPACDGSTATLDTTNNVCVCNNAGNTLNTGGLSCSPPCDGSTATLDTTSNTCVCVDPNTKINNDGVSCSAPPACDGTSAIPDPNGSNTCVCTNPNTNINSDLVSCSPVCDPSTATLDTTNNVCTCKTPGDTLNSNSVSCSTPLACDGTTATLDTTSNTCVCNTASDTPNAGGLSCSPPCDGTTATLDTANNVCACNNPSIDTLNPGGISCSPPCDGSTATLDTTSNACVCTNSVNTVNADGITCSPACDGTTATLDTANNVCTCNNPNDALNGDAISCSPPPACDGSTATLDTTSNTCVCTNSVNTINAGGTTCSPACDGTTATLDTANNVCACNNPNDALNGDAISCSPPPACDGTTATLDTTSNTCVCSNPAVNTINSNGISCSPPCDGTTSTLDTTNNVCVCNTAGDELNSNAISCSPPCDTTTAVIDPAGSNTCVCTDPNNSINAGGTTCSPACDGTTATLDTANNVCTCNNPNDALNGDAISCSPPPACDGSTATLDTSTNACVCNNPSVDTLNTDGLSCSPPCDGSTATLDTTSNTCVCTAPNSGISSNSISCSPTCDISTAILDSNSNTCVCTDPNNSVNSNGISCSPVCDGTTATLNTNSNACVCKTPGQLVKPDGRSCAPRCAALSFLPNDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RE11</accession>
    <name>A0A3D8RE11_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_08254</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RE11"/>
    <dbReference type="OrthoDB" id="3172332at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF4">
        <property type="entry name" value="HYPOTHETICAL CONSERVED PROTEIN (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW72220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="422" mass="47813" checksum="DE8D9ACF824D7D82" modified="2019-01-16" version="1">MAIGALGKQMKAQHQRSSGGLSSSTKHYQSALEQYHKSLRGMRKAIASGQQDLRKALLASLLIFCFESMLGNQVTAALHAARGLTLLHPWKAGNRLHKRARATENTWEARILERELLETFHALDLQVLLFIDNRNNEAHRYTMARLNLMIKAIPQQVQNLEQAKRFWQLIFSRNCHFNQCMQLVGLEVVQEERSDTPWEGSAKFPKGVLLLSDAVEGRGLLNEEQLRYQDDIARWTSASTPLFIEIAAGTNEREKVCAAILQVQAIVSRIMLAGSFITSEMAYDVYLPEFTTITTLCDSVFLYLGSDDHEFASRFHFDIGIVAALFLVGSRCRFDIVRRKALDILFSANIREGMWDSLVVGHITHWLRSIELEHVKEGEMIPVENRAILNAMNVDLFGRRALLMASQGPKDCSLERTALITW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RE70</accession>
    <name>A0A3D8RE70_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Short-chain dehydrogenase TIC 32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_08270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RE70"/>
    <dbReference type="OrthoDB" id="191139at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320">
        <property type="entry name" value="RETINOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24320:SF283">
        <property type="entry name" value="RETINOL DEHYDROGENASE 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW72236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="338" mass="36866" checksum="971CDC0049A71C13" modified="2019-01-16" version="1">MAVSSQPQIQFVERNPPRNSASSLVRNRADQIKGKVILTTGISPGGLGAFFLQAVIKAQPRILILAGRSTSKSEEAARLLMAESSAVEIRILELDLSSLAAVRTAAATVNGWHDIPNIDILVNNAGVMAVDYSITADGYESHFAANHLGHFLLTNLIMDKILASKAPRIVAVSSDGHRLSPIRFEDYNFHNGDVYNRWKAYGQSKTANMLMALSLATKLGAKRNLLAFSLNPGIVMTNLGSHLNLGIDFDSCLEVDRECGYSCGWKTTFEYFTPDEGVATHIYAAFDQDIAAHNGSYLTDCQIGDPFTGAVHAWATSPVEAERLWKLSEKLVGQEFTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJ02</accession>
    <name>A0A3D8RJ02_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HCP-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_07471</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJ02"/>
    <dbReference type="OrthoDB" id="2384430at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032153">
        <property type="term" value="C:cell division site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010972">
        <property type="term" value="P:negative regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000455">
        <property type="entry name" value="Cell cycle inhibitor Nif1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052945">
        <property type="entry name" value="Mitotic_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628">
        <property type="entry name" value="ACTIVATOR OF C KINASE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43628:SF11">
        <property type="entry name" value="PROTEIN DSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="434"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="455"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="494"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW74029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="739" mass="80492" checksum="199671CD25B064E6" modified="2019-01-16" version="1">MAKRPTYIDLRSQSHGTFSSGLASPRGLPSPRLHVAGEIPPDLSPLDAFAAQSRLLAKQLEEESYIEGKRISRLPALGLSSTMGERPGITRSVSTSASLSKDEAVSPISGEDSGMMTEVEHPEFRPVSVHPRMSGVPNFDTPEPSPAPSPRTSIQDDDRFRGRMPSVVADGPGIFGARREQSPGVMQMSPRRANSPSQLRHKPSTESMRRRQQSRRAPDGSLAAGDYDSRALAPPRSPMLAQRQRSPSSLSTASECEGGTTQINTTGFPRPRRRSSGSGFSVSPISPVMYHEGRSPSISSEISVGGTKLPRPAFNFSRPLSRASLPPVEVPSRQASEDSQPSFILVDDTAHTPVSMHSDGFPDVLQGSPAAPTYVYSKFSLPRGKMMQRNSLIFQEGLPQAHFQWEQPVPFSNVQSYDGSSVQAPPSPPSRPSTASIVTSSHNIASAPSQSRPSLDPDRPSFDSRIPSYERGRSVDSRAPLHSEVPGVSRNLESSASSTSPSINSESTIRARRSMHSLAPSAEGSAEEHVTKAIELHENGALKESTYHLRLAARQNHPTGMLLYALACRHGWGMRPNQREGVHWLRKAADFASLEVADDEETAKDGRPVDLLERKTRKAQFALSIYELGVSHMNGWGIEQDKVLALRCFEIAGSWGDADALAEAGFCYAQGVGCKKDLKKSAKFYREAEAKGISMIGNSWIYKPKYQEDDDSKSNGSPGKRSRNKSRTRTMFGRIKPTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJ70</accession>
    <name>A0A3D8RJ70_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_07462</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJ70"/>
    <dbReference type="OrthoDB" id="206213at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010945">
        <property type="term" value="F:coenzyme A diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015938">
        <property type="term" value="P:coenzyme A catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03426">
        <property type="entry name" value="NUDIX_CoAse_Nudt7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000053">
        <property type="entry name" value="Coenzyme A diphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045121">
        <property type="entry name" value="CoAse"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992">
        <property type="entry name" value="NUDIX HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12992:SF24">
        <property type="entry name" value="PEROXISOMAL COENZYME A DIPHOSPHATASE NUDT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="8">
        <location>
            <begin position="76"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="334"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW74020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="367" mass="41379" checksum="8AE22B9796DAA008" modified="2019-01-16" version="1">MSTEDEPLDPRDLLDTQTETHLDENAVAELIESIKEAQYFDPTSMAPLTSASLAAIARLRAYQPPPFATWNRLPLSRRAAVLILLFADRRGDLRVVITMRAMSLRNFSGNGTGHAAFPGGKADTLEETPFEIARREAFEEIGLPQDDKKLPPPFRVEHLCELPYNLARTALAVRPCVAFLHSDDTSGMKSASVEESMIPRLDAKEVAAVFSAPFHNFLRAEDEVRDNETVPGKRSDWYSGSWSDWNKTRWRMHDFQVPIVNQMVSKPKSRDGGQAAISEELDHEELTRYRVWGMTARILVDAARIAYGEDPEFEFNTHLGDERMIENLEKMGQMKEKKLGGPDLSRTDLEEASKKTAAELRKSDAKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RNQ3</accession>
    <name>A0A3D8RNQ3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Alpha-aminoadipate reductase</fullName>
            <ecNumber evidence="6">1.2.1.31</ecNumber>
            <ecNumber evidence="5">1.2.1.95</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">L-aminoadipate-semialdehyde dehydrogenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BP5796_06456</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>(S)-2-amino-6-oxohexanoate + AMP + diphosphate + NADP(+) = L-2-aminoadipate + ATP + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46936"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="1.2.1.95"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(S)-2-amino-6-oxohexanoate + NAD(+) + H2O = L-2-aminoadipate + NADH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12308"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>(S)-2-amino-6-oxohexanoate + NADP(+) + H2O = L-2-aminoadipate + NADPH + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:12304"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58321"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:58672"/>
            <dbReference type="EC" id="1.2.1.31"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pantetheine 4'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:47942"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.31" evidence="6"/>
    <dbReference type="EC" id="1.2.1.95" evidence="5"/>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RNQ3"/>
    <dbReference type="OrthoDB" id="329835at2759"/>
    <dbReference type="UniPathway" id="UPA00033">
        <property type="reaction ID" value="UER00032"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004043">
        <property type="term" value="F:L-aminoadipate-semialdehyde dehydrogenase [NAD(P)+] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000787">
        <property type="entry name" value="L-2-aminoadipate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010071">
        <property type="entry name" value="AA_adenyl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014397">
        <property type="entry name" value="Lys2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01733">
        <property type="entry name" value="AA-adenyl-dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03443">
        <property type="entry name" value="alpha_am_amid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845">
        <property type="entry name" value="CARRIER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44845:SF1">
        <property type="entry name" value="L-2-AMINOADIPATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001617">
        <property type="entry name" value="Alpha-AR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="12" id="KW-0457">Lysine biosynthesis</keyword>
    <keyword evidence="10" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="8" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="18">
        <location>
            <begin position="628"/>
            <end position="707"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RDW75635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1167" mass="128319" checksum="BA8ED6082D1903E6" modified="2019-01-16" version="1">MATRPELPNPNDDLHWSAFRGAIQDIFAANAEAHPDRLCVVETASGSSPRREFTYRQINEASNILAHHLVQSGIQRGEVVMSYSYRGVDLVVTVMGILKAGATFSVIDPSYPPDRQNIYLDVARPRALVVIDKATREAGELTDKVRNFIAENLQLRTEVPGLELKDDGSLVGGLVNGKDVLLEQVSLKSKSPGVVVGPDSCPTLSFTSGSEGRPKGVLGRHYSLAYYFDWMAERFNLTKEDKFTMLSGIAHDPIQRDIFTPLFLGAQLLVPSKDDIQHERLAEWMRDYGATVTHLTPAMGQILVGGASAEFPALHHSFFVGDILIKRDCKALQKLAPNVFIVNMYGTTETQRAVSYFEVPSRASQPDYLESMGNIIPAGQGMKDVQLLIVDRENRDRICDIGEIGEIYVRAAGLAEGYLGNDDLNKTKFVDSWFVDHSRWAEEDKRMAKPLSEEPWREFYKGPRDRMYRSGDLGRYMPTGDVECVGRADDQVKIRGFRIELGEIDKYLSDHPMVLDNVTLVRRNKDEEQTLVSYIVPDMQKWSQWLEQKKLQDDTSGEGIQGRLRRFWPLGDDIKQYLKTKLPTYAIPEVIIPLEKFPVNPNGKKDKPALPFPDAAQLAAARPIGKLENLTKTERDVAGIWGSLIANIDERTISPNDSFFDIGGHSILAQQMLFKANRQWEGANINMSVIFRNPTLKAFSAEIDRRTSAVNGDSQAEDEAEDYAADARSLAKSLPEKFPSAVEKITASTPLTVFLTGATGFLGAYLLRDLLSRSSPSIRVIAHVRALDSNAGLKRVIQTCQAYGVWDPSWSSRITCLTGNLGDARLGLSETAWNQLAQEANVIIHNGALVHWVYPYSNLRPANVQGTLDILALCATGIPKLLSFVSSTSVLDTPYFVKLSAESAANGDRGVSEDDDLSGSSTGLGTGYGQSKWVSEYLVREAGSRGLRGTIVRPGYITGDKTTGVTNTDDFLIRMAKGCVQLGCRPRISNTVNQVPVNHVARVVVAAALHPPKTPLGVAQVTSRPRVTFSQYLAPLQTYGYDVPEVEYPIWSKKLQEYAATENKEQHALMPLYHFATTDLPGDTIAPEMDDVNTAASLQADAEFTGEDLSAGAGVSEEIMGRYLAYLTGIGFLAAPPSGKGAPLPKLTISDEQKAALLRVGGRGALV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RP27</accession>
    <name>A0A3D8RP27_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_06624</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RP27"/>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056693">
        <property type="entry name" value="DUF7791"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF5">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25053">
        <property type="entry name" value="DUF7791"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Nephrocystin 3-like N-terminal" evidence="3">
        <location>
            <begin position="115"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7791" evidence="4">
        <location>
            <begin position="402"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW75803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="815" mass="93077" checksum="8C6F63C258E4A18D" modified="2019-01-16" version="1">MDGNTFDPPPVPAEQPEEQAAVRTPKRLQNMFSSATVNSDNGDDGRDMVKPPRPVQPVNPGILEDWILEALAFSSMTERQDEVAEAHQKTFEWIFDGTTDIIADTPTTPGQDLLPWLRDTNDMGGIYWINGKPGSGKSTLLRFLYDHKRMREELRNWSGTKGLTVAGFFFWTSGSLEQRSQAGLFRSLLHQLLEQHRPLIPKAFPQIWQRYLNMSTKNRINCPIIWSFEELMEGLKLTLQGAKDDTKICLFIDGVDEFDGDHGSIIKLFQSLVTENEHVKICLSSRPWPIFERALQSVPNLKLQDLTLGDRQQYVFDKFEKNVQMRQILHDEPQHSARLMSELVDRAEGVFLWVVLVVRSLLKGLEAGDRVQDILDRLQKLPSDLDAFFQHSLFDYQESTAKKTASQILQLIRAREIVSEFTGDYSSSSLTLWDLALAHMAPEESAQVMASAVVQCQKSKISALCGEMKTRIDSDCAGLLAIHVKSAKHARMPTRFINERGQSPVELAHSKVTYLHRTIRDWLVYCPSVWTKVASITAQMDYEPHSNLLASQVLQLKLPFDEPEKHRRLDEWWSGIVLAMTHARYVHTTDETLHKRSLYLVDEFEKTLTWYWLPKISQLDDHWARATFGSYEARNNKIISHPFLALGTKFGLRDYVMCKVIAARGQRDQLGYRGGRPLLSYSTDFLISRRQSVYPLSDPEFVQELLHTNQDPNLVYIDSGKKEETPWLSCIKLVREALRRKWITAASGDVERWTKILRLYVEAGADVDAVILADAWDPEVTVLGVVESVLDAFDFQGLKAVKDLMLLKSVKPRPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RP85</accession>
    <name>A0A3D8RP85_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DUF6546 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_06442</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RP85"/>
    <dbReference type="OrthoDB" id="4802432at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046676">
        <property type="entry name" value="DUF6546"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20183">
        <property type="entry name" value="DUF6546"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF6546" evidence="1">
        <location>
            <begin position="172"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="DUF6546" evidence="1">
        <location>
            <begin position="241"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW75621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="312" mass="35360" checksum="A5AFDAABA610BC0C" modified="2019-01-16" version="1">MAETLQGTTSSRPVLKVLSLSSSLITGHSIIASTILKLFSILSTWQPTGCLILELSAYSPSDSEHWFKNYHSGLEHEDVGDLIQQQEATTRWHDPKHGWVNGQQVEAPRAPAILRLFSPICLSLPKNLPEVHAVTGFMIRRQLRLYEPWRVWRRSWKILCDKELASVIQDALPSHVRTVSISEEFNDQLALILRRDTPYLRIIDTNPSAGLLTLVRAFASKSRNFERLSISYMIDAQQFSILTQTAPQKEISALLYDASLAALNMPQLESMVFWNSKHGEACAVIYQRNKASRNATLTWRGTWDLELGYDVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPB4</accession>
    <name>A0A3D8RPB4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_06555</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPB4"/>
    <dbReference type="OrthoDB" id="10343106at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW75734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="510" mass="56677" checksum="122F29D880CD1D52" modified="2019-01-16" version="1">MKRARKEPPEALSHVPSPVIYTFDGLVKDYQEHLAHSACVMPAPRSLRSQYGVVYGNANSIWMQNSMDFYLDQMVDWNTQEFWEIGGITKAIEKDDRTRGAVGVEDEITQRRLFTSTLYLEDVLLTISADDCSGSEAKPHLRTARTLEVEESSAIRPVAYDDQTATTVTMNSPQARAAPHARTASFNAVSGRVKAPRRSARTKRTNEPFTVNDKDARKARTTSNGTQLTVSDAPKRPTFDSKLQDAEPLGSLEDSGDDERLNSGAILLRGKVSHKFSKAIIGVTVQDLKDAAMNSAAYWREEITRLTESLRLEAQEAIRRTPPTTQTTPTNPRSVGSAPSSSRSSTPRSATDPRIDESQVSLGRRRDRAVPVFEDPPSPPPSPSPLASYSRPVQQRDEINAHRYGPYVRPEVLERINGGASALPMTGGLPAPDTFVQVGFSSLQERRRFWEQFEGWDSEPEVSVREPLGEISVVSDMNVDIMDAEADSESEDEREYFVVEEPEEDGDLFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RQ35</accession>
    <name>A0A3D8RQ35_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="7">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_06815</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="7"/>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RQ35"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044322">
        <property type="term" value="C:endoplasmic reticulum quality control compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904380">
        <property type="term" value="P:endoplasmic reticulum mannose trimming"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044674">
        <property type="entry name" value="EDEM1/2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679:SF5">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45679">
        <property type="entry name" value="ER DEGRADATION-ENHANCING ALPHA-MANNOSIDASE-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="131"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="316"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="446"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="467"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="553"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW75994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1049" mass="115848" checksum="33EF0C767633B9DE" modified="2019-01-16" version="1">MTPARIAELRQETVDMFYHGFDNYMNIAFPEDELRPITCVPLTRDQHDPRHVELNDVLGNYSLTLIDSLSTLAILASAPPDQLATGAKALRDFQDGVQALVQQYGDGTKGTSGRGLRARGFDVDSKVQVFETVIRGVGGLVSAHLFASGELPITGYEPRPARHTAKTSPQEYKHAPILWPNGLSYNGQLLRLALDLAERLLPAFYTATGMPYPRVNLRHGIPFYVNSPLHEGSPAQDPITGAPEITETCSAGAGSLVLEFTTLSRLSGDQRFEQLAKRAFWAVWNRRSAIGLIGAGVDAENGQWIGPYAGIGAGADSFFEYALKTSILLSGHNTPNVSVPLEPPSESYLDPNTIYNPLSDEENSAEAFLNAWHEAHAAIKRHLYSGTHHPHYVNAHLSTGSPQAYWIDSLGAYYPGLLALAGEVEEAIETNLLYAALWTRYSALPERWSVRDGGIEGGLGWWPGRPEFIESTYHLYRATRDPWYLHVGEMVLEDIKRRCWTECGWSGLQDVRTGEKSDRMESFFLGETAKYLYLLFDPEHPLNSLDAAYVFTTEGHPLLLPRDSSSTKIKNPATTHRAIDYYPELKLTDTCPVAPAAIPFTVSAVVARKDFFHAASLIGLHAIPNMHDPVVSATIETLEDDEFEAFQVPEFPNYTYYPWTLPQNFMPTNGTCDRLPVKTTFTIEFPNSATVSGGGSNAFNLILGPQSLVRLNEGLLIKSISGLKMGMVHESPSPFQGWFDFPVNASWRVWNLANMPLGRDEKVFIPRDIIGDMTDPAFTRVRNSVMLDLVIQLENSAESNNTYEADEGRYESEREDQSHTLNLEGSLSHSAGLAAEYKTMLSSLLHHVTSALRDPATTLLPQPQAPRTYQLASLPAIVPTGKGAAPVIDAPEAIDPNSEPSTEFLSWRSIYFAGYACDERLPEMAAKNHQVIVMRRGGCTFSEKLENIPSFTPSARGLKLVVMVSDPEEDDIDENGNMLWSTSGRLIRPLLDKAQVTPSGLLRHHQISMVMIGGGDEAMALLKDARSLGIRRRYHIESQGLVVGNIIVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RQ43</accession>
    <name>A0A3D8RQ43_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Aminotransferase class I/classII large domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_07023</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RQ43"/>
    <dbReference type="OrthoDB" id="2382073at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004839">
        <property type="entry name" value="Aminotransferase_I/II_large"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052178">
        <property type="entry name" value="Sec_Metab_Biosynth_SDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618">
        <property type="entry name" value="7-ALPHA-HYDROXYSTEROID DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43618:SF18">
        <property type="entry name" value="SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY (AFU_ORTHOLOGUE AFUA_5G12480)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00155">
        <property type="entry name" value="Aminotran_1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminotransferase class I/classII large" evidence="4">
        <location>
            <begin position="60"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW76202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="795" mass="87389" checksum="E12C4BD76D31BCE5" modified="2019-01-16" version="1">MSTPTTTYAERMLKNWLKEHELQSPLVKNESAFNRNLERDLDRARVDFGLMTVKPRWDTSVIDFTTSDFLSLSRSGKIREATKAELERQGDYLLSASGSRPQFGNYDYILEVEKEIAKFHNADTAWIAHSGLLAVVGIIEAATLPGDAIVFDEMMHASTHVGMRVSKAEHRNSFRHNDPESLREVLTGLKDKYSTYRDGSQSILVIVESIYSMDGDICPLKECVDVVQELFPLGNAQLMIDEAHSNGVLGPRGAGLVQMLGLEKEIAIRVHMCSKALGSTGGVILCNKTIRHAIVHSSRCLTYSGAPSMLMVASIRCGYALLASGETREAQERIQTMVKYFFKKLTSESVWEDAVDTGLLRSPLLEDWEQREVHSHIVPIFTRPRHEQYLFFHMSLAGMNAYNISYPVVPKRSSLVRMIFHAHNTEEEIDKAVAAICSWATEMLEIEESGSIGTLPKAAARVYAMQAALAGTAIALYQNIMNLKRKSQPAEDQEPRASKKIQCMLPDSSQDLFRVDGLVALITGGGTGIGLMMAKALALNGASKVYISGRRKDVLEEAAKQSPFGNIIPMVADVSSKEQLEALAESIRSDTGYLNLLVANAGTWGPGPDQRWGASVREFQAEAMKIPMDEWDQCFRVNVSACYYSTVAVLDLLDKGNAQKNYCDGEVRSQVIMTGSVGGFSRILGGRYAYRASKSAVTHLAKCFSTGFQEFGIRVNTLAPGLFPSEMTGPLMKKYGDTAGGDGKMDPKKLPEQRAGLEEEMVGTMLYLASRAGAYNNGSVCVVDGGLTSVMPSTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVU2</accession>
    <name>A0A3D8RVU2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Homeobox domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_06025</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 2 3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVU2"/>
    <dbReference type="OrthoDB" id="6159439at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00086">
        <property type="entry name" value="homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001356">
        <property type="entry name" value="HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051775">
        <property type="entry name" value="Homeobox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24323">
        <property type="entry name" value="CEH-10 HOMEODOMAIN-CONTAINING HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24323:SF7">
        <property type="entry name" value="HOMEOBOX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00046">
        <property type="entry name" value="Homeodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00389">
        <property type="entry name" value="HOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50071">
        <property type="entry name" value="HOMEOBOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 3" id="KW-0371">Homeobox</keyword>
    <keyword evidence="2 3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homeobox" evidence="5">
        <location>
            <begin position="50"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="Homeobox" evidence="2">
        <location>
            <begin position="52"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="123"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="308"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="408"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="449"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="22"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="312"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="453"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="534"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW78173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="585" mass="62951" checksum="A853FF77667441BE" modified="2019-01-16" version="1">MSNASSPPALPAATGDVPPVSSPSGGETDNSQGLSTAPDATTSSGGERKTDNKQKRKRTSPEDQLVLEGFYKQNPKPNKAARAEILKDVKGMNEKEIQIWFQNRRQIHRRKQQPLLPHELAAFGLGNVPPMSSDPITGLGSSQGTEPRSTSPPRDRSSSQGSCVSIDEIRIPQSQDGASPAIGGTGLRPVPMKPESDKQSQLPQAAESKDQSPSDHDTITTAQSVTQSFTSTPGYLANRWNAVNNAFSTPTSSAFLPFATPSVSFPGQPLSCPERIGSLSFSTPPSSQTPPSQIRLSMSLDGKAEIVPLDASPPRTHTPRPSSSGSLMLRRRSGLRRSYSALPFGSLPPKSSPSTFSTPRLPTGRSRDTRTWEFCCDGDARDELTTQAVNESSGSAVAAISLLRSTSSSALKNNSNKRNTPTSKPASNAQGKKPKLGRAMSSLARLQSTTIEPHAKGKGKDGNLVHSPGDSDKENWSPTEFGEAPHPRRRRPLPSGRQKQGYAKRTLGDNHNIPSQAIKFGVPLNKNKRRKSAHKDSEIFEDQENRSQEVGEEVQKFMSGEISPSKKGDLDCVQGLLSLSQGNWR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVV4</accession>
    <name>A0A3D8RVV4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Mannitol dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_06051</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVV4"/>
    <dbReference type="OrthoDB" id="1888931at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050085">
        <property type="term" value="F:mannitol 2-dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050664">
        <property type="term" value="F:oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019594">
        <property type="term" value="P:mannitol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05352">
        <property type="entry name" value="MDH-like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000090">
        <property type="entry name" value="NADP-dependent mannitol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008">
        <property type="entry name" value="BENZIL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43008:SF3">
        <property type="entry name" value="MANNITOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13561">
        <property type="entry name" value="adh_short_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW78199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="265" mass="28341" checksum="3EE87AD3DEF6CF79" modified="2019-01-16" version="1">MQPIPQADSLMGMFSLKGKVVVVTGASGAKGMGIEAARGCAEMGANLAITYSSRPEGGEKNAKELAEKYGVKVKAYKCDVGNWDSVKGFVDEVIKEFGQIDAFVANAGRTADSGILDGTVEAWNEVIQTDLNGTFHCAKAVGEHFKARGRGSFVITASMSGHIANFPQEQTSYNVAKAGCIHMARSLANEWRDFARVNSISPGYIDTGLSDFVDQDTQKLWKSMIPMGRDGEAKELKGAYVYLCSDASSYTTGADIIIDGGYCAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RW72</accession>
    <name>A0A3D8RW72_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N-acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_06171</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RW72"/>
    <dbReference type="OrthoDB" id="2832510at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052523">
        <property type="entry name" value="Trichothecene_AcTrans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791">
        <property type="entry name" value="GNAT FAMILY ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42791:SF16">
        <property type="entry name" value="N-ACETYLTRANSFERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="1">
        <location>
            <begin position="86"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW78319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="227" mass="25825" checksum="0BF1E5698BFC97A3" modified="2019-01-16" version="1">MIREATHEDLRSMAEVLAAAFHHEELFGHLLHPYRDEYPDDYLRYFEYMMWKHLLDPSRRVLVALDQAGAKIVGVGSWERQGSTASRASTAGEMGWLAPQKLYQTLASKWTDAQFKMWPNKAADPTKANVFEESFAFYKHHWAGSRENTWYLAFLGVHPDYQRKHHGKELVEWGIEQATKDGVCASVISSYGSEGFYGRFGFVEVGRSNVGPLAELKGGAIMFTEVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RW80</accession>
    <name>A0A3D8RW80_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GH16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_06181</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RW80"/>
    <dbReference type="OrthoDB" id="192832at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26113">
        <property type="entry name" value="GH16_XgeA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017670085" description="GH16 domain-containing protein" evidence="2">
        <location>
            <begin position="28"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="805"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1020"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="460"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="529"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="565"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1020"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1035"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1064"/>
            <end position="1078"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW78329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1101" mass="112220" checksum="8A5205F39A42777B" modified="2019-01-16" version="1">MLASLLFLRSGAASLVVLSLFLARSHALSPYTQKFAYSGTDFFNEFDFIIGPDPDKGYANYVSNVTGLQRHYVLPAADQQSYNQFSFDRSASTSSTVGRDSIRIQSKQSFTHGLLIADIITMPYGCGTWPKYGTMGSTSNDGAINIIQGINSQTNNIYSVETKGSCSVNPTSSDESGQLLNSACDVTGGCTIQDAYDTSYGAGLSNSPPGSSGGPGGYYATEWTKDKVQMWFFPHDGSLGPPPSDIDMDSPDPTSWGMPHAIFQPSSCTLDDELKNHKIVFDTSFCGVNGAAGVDDNTWKADSTCSTQANTCQDYVMNVGTAYKKLSWQVASLKLFQVPVASPSSSVAITSSTTAAAANSTAQSSAAQISAPFSNVSATASDPSFISQPTATQSSTIISNFSTSLSSMVQSTAIRFSTTQTAQVASNSTMLSSPSVQSSASVTSVSVNSSGVQPSPAAQSTDSVSRSSGLSSSTIASQSVNAAQSSSSLSNSSSQSTTMPPGFQSSGTAQSSGIISASAAISSLRASSNVSPSNTTNLSSVTSGASTQLPEAQSSASLPRETGLSSYSSTSQSSNTVPTPAPSDTGAGGSAISSQPPSETLITSASAPASGVLVAPSTLPSDFATSAGVYREIGCYADPHSNGGPLFSPSEITFTRNSTAATSVHACLSACGTENYLYAGYELGFCFCSNEINSAPQVPCGIGFSRKRQNIQTVVVYALVVPASSSTTSETASAPAPTSSADLSGSLTHSSVISMSSLGSILGSSSTFGTPLIPGQSTNINSNLDLSTLASSTVSAFNTLIFSSVGSGSKSSTSSSPVESGLSSSVPMTTSTVYAVTEYTITSCAATVTDCPARMGQVTTETIALYTTVCPVAEATPTPPPANMISTIYTTKIYTITSCAPSVTNCPARIGLTTTEIIPISTITYPIKPAYTTVIYATYIDVCPTGLTTVTTTTTLTLPSTPAHPVTIPMVTTEKVATFGDQSVTVTCTVPAPDSSEQAGLPVPNATKIVSVLPGSLPAGGSGSSGASGMGSGSILGSSPGSDSSPSNDQSTSGDLTRLPAIQPTTTEPTTPMYTGGTSPSKGMNLVMIGALTLAGVLIAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RW96</accession>
    <name>A0A3D8RW96_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">O-methyltransferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_06108</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RW96"/>
    <dbReference type="OrthoDB" id="1535081at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008171">
        <property type="term" value="F:O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016461">
        <property type="entry name" value="COMT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001077">
        <property type="entry name" value="COMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712:SF17">
        <property type="entry name" value="O-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43712">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_4G14580)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00891">
        <property type="entry name" value="Methyltransf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51683">
        <property type="entry name" value="SAM_OMT_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="O-methyltransferase C-terminal" evidence="4">
        <location>
            <begin position="229"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW78256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="392" mass="43753" checksum="8B56E5DD56B1DA33" modified="2019-01-16" version="1">MRSADQLITDLGEISGSSFANESERVRTRDALFEALRRVQSPWDIVWDQNWVNGATNASVKTLIDAGVFKKWVESGGLPKTCSELAELTGADELLLKRLMRQISGQHLVIETAEDTYAPTPWATALVADPALSAVYGEFYGQLNNPMFRSLPYFLKERGFKNPTDVNDCNWQFWKGTSNNLFQDLAINPAMANDFHAAMQCHSRYNLTPWPDVYPTDTVVSAAKPDRALVVDIGGSKGHDLEKFRLCHPDIPDGSLILQDLPEVVQDVQLDRAISAQGYDFFAPQPVKGARIYFMHNVLHDWPDDSAVKILGNVADAMEKGYSKLLIHESLISSTKPLARVTTSDLTMMACLAAKERTESEWNQVIQNSGLRIVKIWRPPQSVESVIEVELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S230</accession>
    <name>A0A3D8S230_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tripeptidyl-peptidase II</fullName>
            <ecNumber evidence="4">3.4.14.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BP5796_05026</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Secreted tripeptidyl-peptidase which degrades proteins at acidic pHs and is involved in virulence.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal tripeptide from a polypeptide.</text>
            <dbReference type="EC" id="3.4.14.10"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
        <text evidence="15">Binds 1 Ca(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Secreted</location>
            <location evidence="3">Extracellular space</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.14.10" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S230"/>
    <dbReference type="OrthoDB" id="409122at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008240">
        <property type="term" value="F:tripeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04056">
        <property type="entry name" value="Peptidases_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11377">
        <property type="entry name" value="Pro-peptidase_S53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.200:FF:000015">
        <property type="entry name" value="Tripeptidyl peptidase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015366">
        <property type="entry name" value="S53_propep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030400">
        <property type="entry name" value="Sedolisin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050819">
        <property type="entry name" value="Tripeptidyl-peptidase_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218:SF10">
        <property type="entry name" value="PEPTIDASE S53 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14218">
        <property type="entry name" value="PROTEASE S8 TRIPEPTIDYL PEPTIDASE I CLN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09286">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00944">
        <property type="entry name" value="Pro-kuma_activ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54897">
        <property type="entry name" value="Protease propeptides/inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51695">
        <property type="entry name" value="SEDOLISIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11 15" id="KW-0106">Calcium</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9 15" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 15" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="10 15" id="KW-0720">Serine protease</keyword>
    <keyword evidence="8 16" id="KW-0732">Signal</keyword>
    <keyword evidence="12" id="KW-0843">Virulence</keyword>
    <keyword evidence="13" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017763602" description="tripeptidyl-peptidase II" evidence="16">
        <location>
            <begin position="23"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S53" evidence="17">
        <location>
            <begin position="225"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="15">
        <location>
            <position position="513"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="555"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="556"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="585"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="587"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDW80328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="604" mass="66253" checksum="ADEE5BFEE3498E91" modified="2019-01-16" version="1">MFFSQKAFAALMALAYIGCVLCHPAVASYQVFESVKAVPSGWRVQSNLDVNRTSPMQIRMHLKQQNVAEFEQSVYDMSTPGHSTYGAHMTQNAINDFLQPAEETVKLVMTWLAAAGLQSNSWLEQDWMHINATVSDVESLLDARYYYFQNAEINTTVLRTLKYGLPISLHEHIDMVHPTSYFPGRTLIKPVISDHKESLEASRRRHLQYARRFPGGLDVASCNITVTPDCVKALYGFKDFHPSPTNGNKFAVAGYLQEYVQDNDLEAFLNIYDVEANTTGYEFISVNGGLNTQYWGKDTVESAIDLQYGISLNYPTPVSYYQTAGSPPINYDVDTTTDNSEPYLEWLTYMLALNDSMLPQVVSTSYADDEQTVPEAYARTVCNLFAQLAARGVSALFATGDAGPGGACISNDGTNTTRFIPTFPASCPFVTAVGATQHVEPEIGVSFSGGGFSNYFSRPAYQEAAVSSYLRKHGDTWAPYFNSSGRAYPDVSAQGTNVSIIYWGGHRYEAGTSCSTPIFASVISLLNSERLSKGKRPLGFLNPWLYSEAAGGLQDIISGRSEGCSGWTTTPGAVIDGAGWDAVVGWDPATGLGTPKFKELLDYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2L4</accession>
    <name>A0A3D8S2L4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SEC7 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_05098</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle</location>
            <location evidence="5">COPI-coated vesicle membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="18431at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030663">
        <property type="term" value="C:COPI-coated vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1000.11:FF:000003">
        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.20:FF:000002">
        <property type="entry name" value="Brefeldin A-inhibited guanine nucleotide-exchange protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032629">
        <property type="entry name" value="DCB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015403">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046455">
        <property type="entry name" value="Sec7/BIG1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF375">
        <property type="entry name" value="LD29171P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20252">
        <property type="entry name" value="BIG2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16213">
        <property type="entry name" value="DCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09324">
        <property type="entry name" value="Sec7-like_HDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017649771" description="SEC7 domain-containing protein" evidence="7">
        <location>
            <begin position="17"/>
            <end position="1825"/>
        </location>
    </feature>
    <feature type="domain" description="SEC7" evidence="8">
        <location>
            <begin position="624"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="505"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="593"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1031"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1542"/>
            <end position="1579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1794"/>
            <end position="1825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="240"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="511"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="533"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="595"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1031"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1544"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1795"/>
            <end position="1811"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00060451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW80400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1825" mass="204821" checksum="962AD608779CB11F" modified="2019-01-16" version="1">MSSLVFVVSALEAIAASKEASKQKQLGDAVQKALKLIKENDGQLPDPEIIFEPLQIATRSGSIPLTTTSLDCIGKLISYSYFSVPSSPNADSEADRAPLIERAIDTICDCFQGETTPGEVQLQIVKSLLAAVLNDKIVVHGAGLLKAVRQVYNVFLLSKSSANQQVAQGTLTQMVGTVFERVKTRIHMKEARLNLSRLGKTAGNSSYTVDATESILEVPGAHEETIEADGGSISAPSEAHSNEEGPKLTLKDLEHRKSFDDSQMGEGPTMVTQLKPSVASPRSVSEQTQAESADDTLDSDDTEDEVHIRDAYLVFRSFCNLSTKVLPADQLYDLRGQAMRSKLISLHLIHTLLNNNMLVFTSPLCTITNSKSNEPTGFLQAIKFYLCLSITRNGASSVDRVFEVCCEIFWLMLKFMRAPFKKEIEVFFNEIYLALLERRNAPVAQKFYFMNILQRFCADPRALVETYLNYDCDRSLNNMFQNLIDDLSKASSAPVMVSPLHQQQYEERNSKNSAAEWQSRGTLPPPLSAAHMIDPHPNPDGEIPKEYVVKRQALDCLVETLRSLVNWSQQGIADVTGGMETDIRASEDIRASIDPSMNDSSSRIINGDTPMPPSTPILEDDPEHLEKEKQRKTALSNAVKQFNFKPKRGIKLLVSEKFIPSDSPEDIAHFLLSESKLDKAQIGEFLGEGDERNIAIMHAFVDSMDFTKRRFVDALRQFLQSFRLPGEAQKIDRFMLKFANRYVTGNPNAFANADTAYVLSYSVIMLNTDLHSSKVLKPMTREEFIKNNRGINDNANLPDEYLIGIYEEILNDEIVLKSEREAAAAMGALPSQSGGIASGLGQALATVGRDLQREAYLQQSEEISHRSEQLFKNLFRNQKKNAAKSGTIKFIPATSFKHVGPMFDVTWMSIFSGLSGQMQNAHNIEIIKLCMEGMKLAVRIACLFDLETPLEAFVSALKNYTNLNNPTEMQAKNVEALKVILEIAQTEGNLLNGSWRDILLCISQLDRLQLISDGVDEGAIPDVSKARIVTAQRQDSTASRKSTQSVRTRPRQRSATTSTGFSIEIGNESRSDEVIKGVDRIFTNTANLSGDAIVHFVRALCEVSWDEIRISGSNESPRTYSLQKLVEISYYNMTRVRFEWTNIWVVLGEHFNRVGCHNNTAVVFFALDSLRQLSMRFMEIEELPGFKFQKDFLKPFEHVMSNSSVVAVKDMALRCLIQMIQARGENIRSGWRTMFGVFTVAAREPYESIVNLAFENVNQVYKTRFGVVISQGAFADLIVCLTEFSKNMKFQKKGLQAMETLKSIIPRMLKTPECPLSNKTVVNSDGSPKTGEMIANQPSRTSQEEAFWFPVLFAFHDVLMTGEDLEVRSNALNYLFESLVRYGGDFPPDFWDILWRQLLYPIFMVLKSKSEMSNSLNHEELSVWLSTTMIQALRNMITLFTHYFESLEYMLDRFLDLLTLCICQENDTIARIGSNCLQQLILQNVNKFKPEHWTKIVGAFVDLFEKTTAYQLFSAATSATQSNGLENGVSPIDESTADEKSLKINGSNGAANSDTESVVDDEARTPTAASSELEDYKPQPGLQQQPVVVTAARRRFFNKIITKCVLQLLMIETVNELFSNDAVYARIPSPELLRVMGLLKKSFLFAKKFNENKELRMRLWREGFMKQPPNLLKQESGSAATYVSILLRMYHDEGEERKSNRADIESALVPLCADIIRGFVQLEEESQQRNIMAWRPVVVDVIEGYTNFPAEGFEKHIDVFYSLAVELLSRDMSVEIRLVLQGLLRRVGEVKLGLPPQRRPSTPSSPTSTQSFYPGMGSRRSSRRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2L7</accession>
    <name>A0A3D8S2L7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Carbohydrate-binding module family 50 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_05206</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2L7"/>
    <dbReference type="OrthoDB" id="5985073at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.350.10">
        <property type="entry name" value="LysM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018392">
        <property type="entry name" value="LysM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036779">
        <property type="entry name" value="LysM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006583">
        <property type="entry name" value="PAN-3_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08277">
        <property type="entry name" value="PAN_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51782">
        <property type="entry name" value="LYSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017829084" description="Carbohydrate-binding module family 50 protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="572"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="domain" description="LysM" evidence="4">
        <location>
            <begin position="701"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="445"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="445"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="480"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW80508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1095" mass="114838" checksum="7F4680FA11353912" modified="2019-01-16" version="1">MSLFVFVSVLLSSIHGFPPAYATEFDVEACRVITVVESYSLINGYFPANTTIPVDSTSTVTITNAPTSLSTTVTILSTVSSSTTDSEPIKPGLFLPDVFQLKPKPPPLQQHWTTSTVYKTNVLTLTDCGIAECITSTITETIVDYTTVCPTKAGSHSASTLESPVTTTIPQQLYVSATPTSVLYPENTVTSIESTILYPTNIATPASLVSSIGSTIAPRGLSSAVTPGNSSAFNCYKYNGLIIIYHTARPNDIVLSFNIPTPNQKRDSQYLSSAGLPVSDCNTAVKISLQDGQLADISSGTPAYYYVFPNVQHSVFAPVPPGAQVPPGSSNIFFSINDANELVWNPYGNSTLDVMFELDSKSRVQAVSDGYLQPGSKRIYLQVLRVSADGSCQALPSSSLVANTTVPLTSADYGSSLEPPTTTPPSSINLGAGVTSVSSISASTSSSSASTSLPTSRNVLTSSFTSRGRRTSSNPHAPISSSHTKLPSISSSSSSSLISGASASNTATSTTRDLSSVISPTVAVLIPSTISIATTTQPTELNSLTSSTSFPAMTTNSTITSATSAPAASLVCGQVGHPTGKVLQYELQSPVALATCFSYCASDSRCLSFYYGHSNCYLFNVSVANTGFHADVSSNYVAYDKNCLSPSNFSTLNLSPTSQPAASSSIATSTSASSALPSSAACVPIPSPTYAPASTTSDCCEWYIINSTDNCATVEDMFNVTDAYFRLLNPSIDTNCYNLLGGIAYCVSGLPQPVSINTASAGYDPTSTAACTPTTTTPQICGATGFPGDSVVQLDSSYESSASACAEFCKSYGGCLSIYFYHDTPDQIGCYLMGNAVAKTSYHNTTSMGSGYTVYDIDCFYPDSSSTACAVGASSTYQPSTVATSTSLPSMITSSAALCTATAAIVNGGFESSPVSIEPWMLSSPGNDYTYPFITSGEAYTHSGDYSLLVYKDAPQNNISWVLNQTVSICPSTAYTFTFWGRSNGERNPTHCPIEVCFGDMCNEVADVIDLDFTWMQFQSQYPGGAAATLAVSIATASCGQFILLDEVSFDIASSAPLPAVTASTVDCSGGFNSTVCEGIQGCYWSDYYAHCFPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S319</accession>
    <name>A0A3D8S319_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_05390</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S319"/>
    <dbReference type="OrthoDB" id="10249309at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1070:FF:000002">
        <property type="entry name" value="Translation initiation factor eIF-2B subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1070">
        <property type="entry name" value="Translation initiation factor eIF-2B, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051501">
        <property type="entry name" value="eIF2B_alpha/beta/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042528">
        <property type="entry name" value="elF-2B_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="10"/>
            <end position="19"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW80692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="388" mass="41686" checksum="39185F517C41EC83" modified="2019-01-16" version="1">MGKKADASRPLTPGEEGSTTPPPLAGHPPALHRMATVGNAPTMTSTGGAFDIVETYHRLLAEDPDLTMPVAAIEALIEMLMHSQAVTVMETLDLVKAQSDYLKSRIPNSISLSAGTDLFQRYMISSLKPSSTGNFETVRQHLLTNGRLFVTRAKDARQRIAAYGKHFIRDGSVVMTQGGSRVVGNLLSKAADAGASGGNVRFKVIYVMNEGRNAECKAIVSLLRAKGVPVATISEGAVGYSMGKVDLIIVGAEGVVENGGIISRMGTYQIAQLAKAAGKPFYVTAESHKFVRLYPLGQYDLGIEQKVIDFHTEDDDILSVEEKKFADRTPTKDERMDYFENTQIAKTQTSSAAGAVDFTPPALISALITESGVLTPSAVSEELISVWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S383</accession>
    <name>A0A3D8S383_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Elongator complex protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_05450</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ELP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S383"/>
    <dbReference type="OrthoDB" id="289162at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19494">
        <property type="entry name" value="Elp4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008728">
        <property type="entry name" value="Elongator_complex_protein_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896:SF1">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12896">
        <property type="entry name" value="PAX6 NEIGHBOR PROTEIN PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05625">
        <property type="entry name" value="PAXNEB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="368"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="40"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="382"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00020265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW80752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="395" mass="42567" checksum="C018668B7AC9D368" modified="2019-01-16" version="1">MAFRKRNVGIAQPGSSPSSIEITEKKSIPGVRPSPLDGRPTTSTGTHSLDNLLAGHAGLVLGTSLLIEESGTTDFGGALLRYYAAEGILQGHQIHVFGMNEAWGRELPGLGSAESSRSAKKETAADDKMKIAWRYERLGEFGVGARDRTVAPPSATSSGSAGTFCHDFDLSKRLTLPSTTQMQFVPIITRPNLEFATLDSNKSPFNTFINHIANYLSNSSSNTIHRVIIPTILSPALYPPHASRPEIVLQFFHALRGLLRKYPTQLTVITTLPLTLYPRSSGLTRWMELLSDGVLELSPFPSTSVATKSAPGVTTVQEEPPQGMLNVHRLPIFHERGGGGGEASGFGNDLAFTLSRRKGLVIRPFSLPPVEGDSEAQQGGLESDHGKATKVDIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3D1</accession>
    <name>A0A3D8S3D1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acyl-CoA dehydrogenase/oxidase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_05464</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the acyl-CoA dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3D1"/>
    <dbReference type="OrthoDB" id="10254877at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003995">
        <property type="term" value="F:acyl-CoA dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033539">
        <property type="term" value="P:fatty acid beta-oxidation using acyl-CoA dehydrogenase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.110.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.10">
        <property type="entry name" value="Butyryl-CoA Dehydrogenase, subunit A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050741">
        <property type="entry name" value="Acyl-CoA_dehydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046373">
        <property type="entry name" value="Acyl-CoA_Oxase/DH_mid-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036250">
        <property type="entry name" value="AcylCo_DH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009075">
        <property type="entry name" value="AcylCo_DH/oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009100">
        <property type="entry name" value="AcylCoA_DH/oxidase_NM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083:SF28">
        <property type="entry name" value="ACYL-COA DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_6G10880)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48083">
        <property type="entry name" value="MEDIUM-CHAIN SPECIFIC ACYL-COA DEHYDROGENASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00441">
        <property type="entry name" value="Acyl-CoA_dh_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47203">
        <property type="entry name" value="Acyl-CoA dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56645">
        <property type="entry name" value="Acyl-CoA dehydrogenase NM domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acyl-CoA dehydrogenase/oxidase C-terminal" evidence="5">
        <location>
            <begin position="61"/>
            <end position="215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW80766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="228" mass="24845" checksum="E4FEF9BCDEA7A885" modified="2019-01-16" version="1">MTLVRTGGEGASGLSMILIPRLPGISTRKIEIGAGGLSATTYITFEDVKVPAEYLIGEESQGFRYTMSNFNHERLWIAFQAIRGARICLEDAMIWCQKREAFDKKLIDMPVVRHKFGHMARQIESLQAWTEQIVFELDNLSHARGSKLLGGVTALLKVQAGIVSKYIADESVKLMGGLGLTKTGQGARIEAFSRGVITLIVPGGSEDVLLDLGVREAVKLGNKAKANL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3J3</accession>
    <name>A0A3D8S3J3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_05543</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3J3"/>
    <dbReference type="OrthoDB" id="2504266at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046784">
        <property type="entry name" value="Eap1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20566">
        <property type="entry name" value="Eap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="628"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="119"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="448"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="467"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="517"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="562"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="631"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="683"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="712"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW80845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="781" mass="88000" checksum="48E7CF5FA73E06F6" modified="2019-01-16" version="1">MAMRYTPEELKHLRQSPLVAKPTGLPPAEQWMGLPTDNARTQSNRQSGDRSKNHNAPNLPAQENRRPAHVSRNSTSNISQITCVSNVLTCADPEDIVLGPPKTSFMSATSIRNAGKPFDSPDRPGLRTIDSRDRYSFRDKVGDSDHERSRDARPNSLRPKRTDGESDGEGWSTVKPRKSFGTEGAERFNGRMGVTGHRDDKKEDRKFKDREDRDVKERHSRGFENFTRDKERERDHDHPDGEGRRNGNGRGRNEPSWFKEDAPSTPRDRNSNGDRFTDRNRGWREKDDRAPDRGDRTDRRWDRDQRQERDPEWMDELANEKNQAHTQEDFQKWKEQMAGKDGAKVQPTEETRQIPDAFAPGSFFGVEKAKVETPLPIDTGPDKFFGMWATSKDSPENEAVVESKKEGLVKSKTSGKASRFASLFTPQEEPQRRATEPTPPMPAAPQNALESLLTSNTQTTSEKEAFQQLLQKLQRQTLAASGSTPPINPAQQPKPPPQESKPQSAPMPVPEPFQQYRPERQDEGRQRDRNSQQALLTDLLSQRQMTGSQPSAVRPEQMLSELVSQRQTTLSQSSVRPDHPQSRNSNTEFLMGLMQSAKAAPQPQRTEELMLRMPPQKQQIDRQIQHQLMMEQREQEIQRERNAAQRQNQGRPGPQFFDERGGPPMQILQRPPPPGLEQMPPSWAQQPNQLSASQQRHVAPPPGLAGPGRGGMPMPQQMFPPGLPMGSFPPDVPNMRAPPGYYGPPPPGFPPQMSGFPGPDMAFGAGNFDGRGGPPPGFRRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S989</accession>
    <name>A0A3D8S989_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glycoside hydrolase family 71 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW82909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S989"/>
    <dbReference type="OrthoDB" id="1046782at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051118">
        <property type="term" value="F:glucan endo-1,3-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11577">
        <property type="entry name" value="GH71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005197">
        <property type="entry name" value="Glyco_hydro_71"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03659">
        <property type="entry name" value="Glyco_hydro_71"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017763305" description="Glycoside hydrolase family 71 protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW82909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="436" mass="47174" checksum="A3B5797CDBCA2399" modified="2019-01-16" version="1">MVLLKSLLVLASACLPVVSSKYVFAHVVVGNTAAHTVDTWKTDISLAAAAGIDAFALNIAYPDTNIPTQVANAFTAAEAMFTNGTDFQLFFSFDYLGGGQPWAATGTQSVASYLTKYKTSSAYFLYNGLPFVSTFEGTGNIQDWAQGGTIRSTVGDVYFVPDWTSLGTSGISAALPDIEGFFSWDMWPNGAADMSNTTDLAWKDAVSPKTYMMGVSPWFFHSTVGGQDWVWRGDDLWADRWEQVMEVKPDFVEIVTWNDFGEAHYIGPIHSEDEIAAGAADFVNGMPHDSFRDLLPYYISQYKGTNYTITEDLMQYWYRTAPTTGGSAGTVTGNIASQGQEVVSPDAVMQDKVFFSALLKDSATVQVQIGTNAAVSYRGTKGVNHWSQPFNGQTGNVTFSVVRKGAVVKQGKGAKITATTQLASGLTNFNTWVGGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S9N6</accession>
    <name>A0A3D8S9N6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NTF2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04557</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S9N6"/>
    <dbReference type="OrthoDB" id="1162399at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="155"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="477"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="578"/>
            <end position="587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW83066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="587" mass="63839" checksum="9824416394D67C91" modified="2019-01-16" version="1">MALQGAYKQFLAAPSSALLAEDASLNYITTLVTLSGSAQIVKHLGAQHNQLKKTEEIFLNVVEGPNSIAAEVHTTIEFLTSGSSYLPGLDDNFLADRIVTFPIIHIVQFDAAGKIQQIRQSWDQGSLLKLIDVIGKSGRNWPIRDGKDQIKLISSTVASGGKPVDGAGKEERPVNSRENSKNITRDPHASLSLFAPREDHENPSLPAVVAPRASVKPTQRDLSDLLGSHEGDIPAPQAYNRARATSSNTSKSPDKPEHMQNYLPSRLFDNDENSAMPSPAAKSNERFYRPNPTKFQHFDFGEGEDVPESKPATKSTKDKHSSQWDFEDFNTPAKAVPTRALNNRPGEVRNWGNSDDEVVDSPVKVKKANKPRKDAQTHFDFQDEVVPDEPRLIGRPRGAGQNTGLGLYQNNLYGDEESAEAPAPASNKTTGLANVKDRRKDFDAHFTMTDDAPADVPKAAPLGQDRAKAVKMMDSNWASYDESPNQKENFSESTNTSRPTTANAKGPLSEVTQGINIAGDGMGSRKGAAAIASPKQKGINIGGDGMGGRKGTGRSWGFGDESEGEEQPAYRTGKAQHKQPTNDFWDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SA84</accession>
    <name>A0A3D8SA84_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04773</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SA84"/>
    <dbReference type="OrthoDB" id="5427526at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW83282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="383" mass="41474" checksum="5F48D83E7B1E7CDC" modified="2019-01-16" version="1">MPSSPRTPHARHSRDLSMNTDFSFASPLNYTSSSRRDSKASQNTPSTPNRNSLVRSDSNFGIDVYGAGGAAPSNGLGNLADELADAWSDGEEEDEEPDLNFHQESVEVVRDSGVDIPFSPSQPPLKSAGLVPPTPMQKGHRRAASDYDGSDYGGDSDLESPGVPPSLAARIDAVEGLVRRGTENNGTDRDGVVLRVIESLKDLGAQGGVEGNATRLITAHTALSTHLIHQTRLLQNLAYPLFSPLSTPPDSETIDELLPLLLTMTESIPRPTTAAFTSLTALHTLTADLVQTLNYLSDTLHMSRQTTTTAARRLKSAMELVKEIRKEEEEREEGELWLQKGDWGRRLESRECAGVCGDVVGGFEEVCNGWRERLLNQAEGVGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAE1</accession>
    <name>A0A3D8SAE1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_04575</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAE1"/>
    <dbReference type="OrthoDB" id="47007at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009688">
        <property type="term" value="P:abscisic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000084">
        <property type="entry name" value="Short-chain dehydrogenase reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760:SF121">
        <property type="entry name" value="3-OXOACYL-(ACYL-CARRIER-PROTEIN) REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42760">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASES/REDUCTASES FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW83084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="274" mass="28703" checksum="183BA45EB3EC81BC" modified="2019-01-16" version="1">MASKSTAVTRDYGKRTAIVTGSARGIGKSIALRLAEDGFDVCINDIAANQSGIDETVAEIQALGRQSLGHVADVSQLSQVEGLIAATVEKLGKLDVMIANAGIAQVKKPLDLTEDDVRKMFDVNVFGVFNCYTAAAKQMIKQGGGGKIIGAARQGSLIVAFKPFAMLAHYSASKFAVRGFTQAFAMDLAKHKITVNGYAPGIVGTAMWDLIDEGIGSSTGAAKGETIKQYSQTIALGRTSVPEDVAKCVSFLSSPDSDYITGQTIVVDGGIVFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAR1</accession>
    <name>A0A3D8SAR1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NCS1 nucleoside transporter family protein-2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_04369</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the purine-cytosine permease (2.A.39) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW82878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAR1"/>
    <dbReference type="OrthoDB" id="2018619at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015205">
        <property type="term" value="F:nucleobase transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11482">
        <property type="entry name" value="SLC-NCS1sbd_NRT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.4160.10">
        <property type="entry name" value="Hydantoin permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001248">
        <property type="entry name" value="Pur-cyt_permease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045225">
        <property type="entry name" value="Uracil/uridine/allantoin_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618:SF4">
        <property type="entry name" value="ALLANTOIN PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30618">
        <property type="entry name" value="NCS1 FAMILY PURINE/PYRIMIDINE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02133">
        <property type="entry name" value="Transp_cyt_pur"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="403"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW82878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="565" mass="62928" checksum="CF7CD26576F09872" modified="2019-01-16" version="1">MTLKEWLKAAEVKSEVETTRWINDDIKPIEYSRRTWGPWTFHNYWILINANISTYLTGSALIPLGLNWWQAVICIILGNLIATLYIVVNSIPGAYYHIGFPVANRYVWGMYGSQFVIWNRILLSLVWFVLLWKPCSIMYGFQAWMGGECFYIIMMSLDPLLEKHVPNTMAANTGVTTAQFLAYIMFSLISLPFIWIRPHKLEKFMMASGIIVVVFMTVLLIWALATMGPLGFGSTITDTNVLQGESSTVGWLMIYGIISTIGSIAAGILNQNDMARFSRKPRDAITGQVISFPFYGSISAIIGILVTAATQQRFGSALWNLPDIFTTLIERGGSRERAAGFFAGLALVVSQIGVNVPGNALAGGCDLSATFPRYINIRRGAYLTALFSIAVNPWKLVSTSTTFLSVLSSYSVFLGPTVGMMISSYFVVNRCKINVDDLFLGNSQSTYWFTYGVDWRAIIAWIFGVFPSFPGFLASVSPGIRVTVGWTHLYDLCFISGSCIAAFVYILLHYIFPAPKLQAFLKNSASPKELMVKYQDSWDSHLSSTVVGGETEEDKVSHATEIKKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SH49</accession>
    <name>A0A3D8SH49_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_03826</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SH49"/>
    <dbReference type="OrthoDB" id="40134at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000039">
        <property type="entry name" value="Neutral amino acid transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF697">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="351"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="424"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="47"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW85501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="467" mass="49882" checksum="2A416E5E94666AC0" modified="2019-01-16" version="1">MSDIKNAGSDEEHAHPTYEKGVVEDVLDPLEENEVFKKTHDGVDFRTVNWPRASVIFLKVIFATGVLSIPSAMYSLGAVGGALSVIGWGALNTYTAVIQGNFRNSHAGCHSIADMAGVLAGKVGRELCGGLFLIAYVLCAGSGIIGVSTGLNALSTHATCTVWWSFIATIVIAGLASFRKFQQIGWLTWAGFVSIFVAVFIVVIAVTTRDRPAAAPQTGPYDLGYHAIAYPTFQAGIVASATIFVSSAGTSAFLPVISEMRKPKDYKKALYVCMALVNAAYLSFSLVVYKWCGSWVASPSLGSAGPTIKKVSYGVGLIGLIVSAVLYLHVAAKYLFVRILRNTRHLQHNTMVHWVTWLSCTFGLCSLSFILAEAIPIFNYLIALTGSVCFAPLAIALPGALWLYDHSHYRSGTVGQKAIYWAHWFLPVLGAFLCIGGTYGVVQEIIDAYAAGTIGGAFSCADNSGST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SI05</accession>
    <name>A0A3D8SI05_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SI05"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF31">
        <property type="entry name" value="LAEA-LIKE, PUTATIVE (AFU_ORTHOLOGUE AFUA_8G01930)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW85985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="332" mass="37271" checksum="7C0F390D1BF9C0BA" modified="2019-01-16" version="1">MADHPPPDVTAAPLVPEDNWADDDSAYDAGSIATSTTSLNTSVLKYRQENGRSYHSYKDGKYLVPNDEGENDRLDLQHHAFYLTFSNKLFLCPIGPETPLRRVLDVGTGTGIWAIDFADEHPESEVLGVDLSPIQPSFIPPNLVFQIDDVEEPWTFSSKFDFIYCRAMTGSIADWPKLFKQSFDNLADGGYFEVTDIAFPIMTDDNSFPPDSALKKWSDLVVEGFATIGRDLASATNNKALVKDAGFSNVTEFRYKWPLNRWPKDPAAKELGMWAHENLSGGIEGISLAIFTRVLGWSREAMEVFLVDVRKELKDRNIHSYMQVIVVYGQKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMU3</accession>
    <name>A0A3D8SMU3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_03296</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SMU3"/>
    <dbReference type="OrthoDB" id="7344096at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044159">
        <property type="entry name" value="IQM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31250">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN IQM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31250:SF27">
        <property type="entry name" value="IQ DOMAIN-CONTAINING PROTEIN IQM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="169"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="218"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="366"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="628"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="40"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="169"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="222"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="642"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW87602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="676" mass="75563" checksum="DE9C314045659DE8" modified="2019-01-16" version="1">MTPGFANCEHSNTAISSPPPLALPYAQQGIKNLPQRHRSSSTSHSQPSPSGSQISNQDELDARLRHDSVISSVKHSQRSHQEYLDSLILPSKEGMDRISTVQEAKEEEVMQKRLETNVEDLNEVERTRAAGLIQRNYRGHRARRELAGMGLDPSTRWVEAVKEARYRKMTEPRPRASGEVRRPSVESEGTLVSSGMPISAVQSFARQNWKKVGLITRRAGGDEESDSGESEEEDTEIPEEERLARKKRKAEEKAVRQKAAKIMDLQYFLEMVDLKHRYGSNLRTYHEEWKQSDTHENFFYWLDHGEGRYIDCQGCPRERLDREQVRYLSKEERLNYLVKIDKEGRLCWAKNGARIDTTEKWKDSIKGIVPDTDETPPFAPVREEAAGRTSSISSVSSTSSQGEPGHKHQNAEAESSSVAARADKYATPGLDNARGVKKVKHVSAATIFNKLLRGSVKKNTWIFVADTSFRLYVGIKQSGAFQHSSFLHGSRISAAGSIKIKDGRLSKLSPLSGHYRPPVANFRAFVHSLKDNGVDMSHVSISRSYAVLVGLEAYVKTRKKGKKVVKNMVHAKEKILSPAEVAKQEEEQRDKSESAALERRFLEVKQKADAGDDAQKNIGLFKSMSLGSWRRSAKSAASVHGRGAESSKKERATGIEAPGPGPENAIAPEGHRNLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SN62</accession>
    <name>A0A3D8SN62_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_03420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SN62"/>
    <dbReference type="OrthoDB" id="21204at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16473">
        <property type="entry name" value="RING-H2_RNF103"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45676">
        <property type="entry name" value="RING-H2 FINGER PROTEIN ATL51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="221"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="352"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="293"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="425"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW87726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="549" mass="61499" checksum="D26649E354F0A53B" modified="2019-01-16" version="1">MYLCSLLFPNIEWPASDTDKDLDRVVARLRPNMSYSESIDGSEFTILSTHNIPADGKMRGFLYVPDLLESDPCVNISKPYVPSNVTRQANLPPTDFTLIAIAPWINENCTKSYLAAAKLDPMRALIFYKPDNSTNPPPPISDPQWNLHDGGRWKSSNQYPVFAVSGAMGARMIYESSLYSGNLTNVPHGHEISEIPNIDVRDYVRIFTKIRVPGSSKTPGAWAYIFVIIALLATLLALTSASMHLLLHQRRKALQNRVERGEVNLETLGIKRLTVPATMLSKMPLFVYGHEGEKRRPVSDHPEKSVAALGQQEIPASPPGYESSQIEVAIAESQIGTSTASDIHTSYSQPSCSICLEEFQANITTVQQIPCGHIFHPECIETYLSNHSSLCPLCKRSVLPLGYCGTKITNNMVRRERNMRDLRSRVTVHDSTSESEQGTERSFLPGPIRVMTTFSSSRSRRNRRIPNPISLQPHEPLEESNSPIDPRESLLGTQMPQPLTPGLSRREIAQRRVLELARRSPLLEDIDSLHRRRIPAWRKTLVKAFPGFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SNM8</accession>
    <name>A0A3D8SNM8_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative sulfide:quinone oxidoreductase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_03604</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SNM8"/>
    <dbReference type="OrthoDB" id="5376590at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070224">
        <property type="term" value="F:sulfide:quinone oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070221">
        <property type="term" value="P:sulfide oxidation, using sulfide:quinone oxidoreductase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000203">
        <property type="entry name" value="Related to sulfide:quinone oxidoreductase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015904">
        <property type="entry name" value="Sulphide_quinone_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10632:SF2">
        <property type="entry name" value="SULFIDE:QUINONE OXIDOREDUCTASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW87910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="453" mass="49556" checksum="6C7125CC485B3846" modified="2019-01-16" version="1">MFGRRLTLAARPTGRTAIPVHNARPIRHLATAAPVSSVDRNHKVVVIGGGAAGLAISHQLLRKGQFVADDIAIVDPATWNHYQPGWTLVGGGLMTKESLRRPLDSLIDPKLKFYNTGVHGFSPEDNLVTLENGDKINYEQLVVVPGITADFGTVKGLSEAVAKPDSLVSSVYDYNVVDKVFGTVKKLQKGVAIFTQPAGVIKCAGAPQKVMWLALDHWKRAGLYDSSNPSASPIQISFATGLPTMFGVPKYAAKLEELRVERGVEGLFEHDLVAVDGNTATFARPGGKEQVTKHFDLLHVVPKNRPHAVIKDSALANEAGYVAVHDGTTRHTKYQNVWSAGDASSLPTSKTMAAITAQAPVLVQNLLLSMDGKEPELEYDGYTSCPLLTEYGKVLLAEFKYGGVPKETFNQWFGIDQIEPRRAFYHLKKDFFPWVYHNYMVKGNWGGPKGWIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXC1</accession>
    <name>A0A3D8SXC1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Maltose/galactoside acetyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_02142</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW90977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SXC1"/>
    <dbReference type="OrthoDB" id="25818at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03357">
        <property type="entry name" value="LbH_MAT_GAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.160.10.10:FF:000025">
        <property type="entry name" value="Hexapeptide-repeat containing-acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001451">
        <property type="entry name" value="Hexapep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018357">
        <property type="entry name" value="Hexapep_transf_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051159">
        <property type="entry name" value="Hexapeptide_acetyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024688">
        <property type="entry name" value="Mac_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416:SF23">
        <property type="entry name" value="ACETYLTRANSFERASE C18B11.09C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23416">
        <property type="entry name" value="SIALIC ACID SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00132">
        <property type="entry name" value="Hexapep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12464">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01266">
        <property type="entry name" value="Mac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00101">
        <property type="entry name" value="HEXAPEP_TRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Maltose/galactoside acetyltransferase" evidence="4">
        <location>
            <begin position="26"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW90977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="220" mass="23598" checksum="D8B0DAF17783B2E8" modified="2019-01-16" version="1">MASTEKNANAIAYAKTLSNTPWCDDYEKMVSGMVYDSFVPELMAGRLRARKLVKKYNDYLPDDATVESLAEDRNVMLKELLGHVGKGVDIDPPFRVDYGCNISIGDGFYGNFNMVILDCAIVTIGDRTKFGPGVSIFAATHPTAVQSRRDGVDYSKEVTIGNDCWIGGNTVILPGVTIGNGVTVGASSVVTKSIPSFSIAVGSPARVIKKVEPVPDVPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXL5</accession>
    <name>A0A3D8SXL5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 11">Mitochondrial import inner membrane translocase subunit Tim21</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_02189</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Mitochondrion inner membrane</location>
            <topology evidence="1 11">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TIM21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SXL5"/>
    <dbReference type="OrthoDB" id="436405at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.320:FF:000002">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.320">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit Tim21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013261">
        <property type="entry name" value="Tim21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038552">
        <property type="entry name" value="Tim21_IMS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13032:SF6">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08294">
        <property type="entry name" value="TIM21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="11" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010867"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW91024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="236" mass="26326" checksum="2CAD20E4F7B123CD" modified="2019-01-16" version="1">MSAQLFAMQPMKALPLLSLPAAIRPMIAARMYATQTGLGTSNASPQPRRRTVTPFNDDGRVAWGDLSGKEKVARTTQQSFNFGMIILGTVLTGGVAYLMYTEVFSLDSKTAHFNRAADRVKADDRCVALLGDSRQIRAYGEPTRSKWARAGPIASTTRKDSRGVEHLVMHFNVEGPLNQGVVNLHMTKRPSESEFVYKYLYLDVKGNQRIYLENADTSPDGSRRSKTKFFGIEWTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXQ7</accession>
    <name>A0A3D8SXQ7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">lytic cellulose monooxygenase (C4-dehydrogenating)</fullName>
            <ecNumber evidence="15">1.14.99.56</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BP5796_02116</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>[(1-&gt;4)-beta-D-glucosyl]n+m + reduced acceptor + O2 = 4-dehydro-beta-D-glucosyl-[(1-&gt;4)-beta-D-glucosyl]n-1 + [(1-&gt;4)-beta-D-glucosyl]m + acceptor + H2O.</text>
            <dbReference type="EC" id="1.14.99.56"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Cu(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29036"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the polysaccharide monooxygenase AA9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.56" evidence="15"/>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW90951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SXQ7"/>
    <dbReference type="OrthoDB" id="4849160at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004497">
        <property type="term" value="F:monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030245">
        <property type="term" value="P:cellulose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd21175">
        <property type="entry name" value="LPMO_AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.50.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049892">
        <property type="entry name" value="AA9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005103">
        <property type="entry name" value="AA9_LPMO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353:SF6">
        <property type="entry name" value="ENDOGLUCANASE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33353">
        <property type="entry name" value="PUTATIVE (AFU_ORTHOLOGUE AFUA_1G12560)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03443">
        <property type="entry name" value="AA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0136">Cellulose degradation</keyword>
    <keyword evidence="7" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017798397" description="lytic cellulose monooxygenase (C4-dehydrogenating)" evidence="16">
        <location>
            <begin position="19"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Auxiliary Activity family 9 catalytic" evidence="17">
        <location>
            <begin position="19"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF03443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDW90951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="250" mass="26271" checksum="F9F913DABB0E9D1E" modified="2019-01-16" version="1">MFIQLLSTITALAATVSAHGYIDNATIAGTYYDGYQPYTDPYTSPLPDRIFRPVQGNGPITDITLIDLQCGGYTAGGISGSQPANLTGGPVAAGAAVTLSWTLWPESHVGPVITYMAACPSTGCKGYLPGTDAVWFKIAEAGREGTSDVWGDTPLMYAGNTTSYTIPSCLISGEYIVRQEIIALHAAYSYPGAQFYPSCHQISVTGSGTSTGPTTKVAIPGVYNETDPGVVYDAYQAQTYTIPGPTVYTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SY64</accession>
    <name>A0A3D8SY64_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ZZ-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_02432</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SY64"/>
    <dbReference type="OrthoDB" id="661148at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14947">
        <property type="entry name" value="NBR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02249">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02340">
        <property type="entry name" value="ZZ_NBR1_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032350">
        <property type="entry name" value="Nbr1_FW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930">
        <property type="entry name" value="OVARIAN CARCINOMA ANTIGEN CA125-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20930:SF0">
        <property type="entry name" value="PROTEIN ILRUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16158">
        <property type="entry name" value="N_BRCA1_IG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00569">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="6">
        <location>
            <begin position="562"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="181"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="631"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="854"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="190"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="225"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="650"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="855"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="877"/>
            <end position="902"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW91267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="921" mass="99986" checksum="6197D69A57BADEA3" modified="2019-01-16" version="1">MSIGPGGHQGVGSNRRRVTAAQPSPSPEPAPEPIAPVASFPHLLRPDLSCGQTLRGPGSLTPTPESSLAGLCKLTLSLCLTTTIMASTSANGDTLVTLKINVEGSNRRFKLPLRDLTPAVLPDKLRFLLAIPSTSEAVFERYSDSAAAFVVLDPANTSVYKQLFRAAKAKLKLRLRVTVQDNEEENTSAVKEESESERIMPKPATVEDEEPTPASPVEQTSYCTPAPASPAAPAAPIEPEQTTVPPSVAEIQRGFEELLINHPRFSYASARSTSSSGCPYKPSYPKSCEDSSSEVPAYRDAAARDAWVAEFANVCHDRQEALRHNTGAPSPTTGIFSVYCNNCNAAIPDEHYHCSTCDDGDFDLCQSCVSNGVVCNGESHWMIKRFVKNGKVINSTTETIAPKPKAPLTFSESKVTLVAQPDEFAAARTCNSCIQELPEENFVTCTTCDDYDLCISCHVGMQHGHNPKHAFVPAVEDANLDLLAKTLLAPGRNMSHNAICDGCDQYVYGVRHKCLDCPDWDYCSACIVNSSFIHPGHRFVPIYEPLYDIAAVNRAYTNKVRHHGICCDGPLCNANNGVQSYIKGDRYKCAVCHDTDFCANCEASPSNQHNPTHPLIKFKTPVRLASITTMGEHGDGSAMPLMGDRRGRTTSKATETTAPASANAATQVQTVADLKPSEAKTEKVEEKAVEKAVEAPAPAPVKADLVAHFVRDTVADGSVLPAKTVFEQTWYLRNGGKASWPAGCSVKFVGGDNMCAVDPEHPTSVHELVSAAESTTCYNEVAPDQEAAFTVLMRTPSKAGNFISYWRLTGPDGNKFGHRLWCDINVEAPKEVKEEPEEEVKEEVTAEGSQMIFPKLEKESPTTSIHEEAPVSKAQPEVDDFEDFVEESLDEESDDGFLTDSDDYEILEADEYLLEAEKAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZ06</accession>
    <name>A0A3D8SZ06_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Aquaporin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_02654</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>H2O(in) = H2O(out)</text>
            <dbReference type="Rhea" id="RHEA:29667"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MIP/aquaporin (TC 1.A.8) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZ06"/>
    <dbReference type="OrthoDB" id="3222at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015250">
        <property type="term" value="F:water channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00333">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1080.10:FF:000024">
        <property type="entry name" value="MIP aquaporin (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1080.10">
        <property type="entry name" value="Glycerol uptake facilitator protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023271">
        <property type="entry name" value="Aquaporin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034294">
        <property type="entry name" value="Aquaporin_transptr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000425">
        <property type="entry name" value="MIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139:SF283">
        <property type="entry name" value="AQUAPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19139">
        <property type="entry name" value="AQUAPORIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00230">
        <property type="entry name" value="MIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00783">
        <property type="entry name" value="MINTRINSICP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81338">
        <property type="entry name" value="Aquaporin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="303"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="365"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="390"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="436"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="486"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="25"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="97"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="135"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="493"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW91489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="505" mass="56877" checksum="E73910C13B014FA4" modified="2019-01-16" version="1">MSGDGAELPIYYGSKTSDGELVKRPTNSPEALVLSSPSRAYTQGGRGYSPERTPVDATYTEATGPPGLRRRPSTQPSRRLSMGDYEDNRKASMTSNRPRDDAFYRDDDRDYRSRRDEFERHPDTYERSRPPRTYRNANYDQPRSSSQKPYYDETLVDRQTSRESSQPAWIGGDKRRAADEESIDGYNYDQHKKKIDIHNLTPEERKEVLRLPWIQWMNSDLKNHFVATIGEFVGTTMFLFFAFSGTQVANIGSTASNDNSSTSNTTTGGSTGFNIAVYLYISVIFGFSLMVNVWVFFRISGGLFNPAVTLGMVLVGAIPPVRAIFLLFAQVAGGIAASGMVLGLFPTQFNVRTTLSAETSLVQGVFIEAILTAELVFTIFMLAKEKHKATFIAPVGIGLALFIAEMCAVFYTGGSLNPARSFGPCVVTWTWDHEHWIYWVGPIIGSLIAVFFYKFIKMLEYEMANPGQDGDDVNNPMKNEQKRREIEEEARQQRIRRIHTHHNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZG0</accession>
    <name>A0A3D8SZG0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">homogentisate 1,2-dioxygenase</fullName>
            <ecNumber evidence="4">1.13.11.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BP5796_02851</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the homogentisate dioxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.13.11.5" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZG0"/>
    <dbReference type="OrthoDB" id="1689029at2759"/>
    <dbReference type="UniPathway" id="UPA00139">
        <property type="reaction ID" value="UER00339"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004411">
        <property type="term" value="F:homogentisate 1,2-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006559">
        <property type="term" value="P:L-phenylalanine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006572">
        <property type="term" value="P:L-tyrosine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07000">
        <property type="entry name" value="cupin_HGO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000034">
        <property type="entry name" value="Homogentisate 1,2-dioxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046451">
        <property type="entry name" value="HgmA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046452">
        <property type="entry name" value="HgmA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005708">
        <property type="entry name" value="Homogentis_dOase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11056:SF0">
        <property type="entry name" value="HOMOGENTISATE 1,2-DIOXYGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04209">
        <property type="entry name" value="HgmA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20510">
        <property type="entry name" value="HgmA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="9 11" id="KW-0408">Iron</keyword>
    <keyword evidence="5 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-0585">Phenylalanine catabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0828">Tyrosine catabolism</keyword>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase N-terminal" evidence="14">
        <location>
            <begin position="65"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="Homogentisate 1,2-dioxygenase C-terminal" evidence="13">
        <location>
            <begin position="342"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="396"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="402"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="411"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>homogentisate</name>
            <dbReference type="ChEBI" id="CHEBI:16169"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR605708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF20510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDW91686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="521" mass="57135" checksum="693F3F14D4BB3083" modified="2019-01-16" version="1">MTINSAETVSVEAPLTKNPPSPAPTLEKSSIATSSVPSTAGISTFGASAIGSFHTSPRPDDPYCYQTGFGNKFSSESIPGALPPGGQNVPQRCPFDLFSEQLNGTSFISSRQTLQNVWMYRIRPSVAHYPLTPMSLNEDIEACFSTENTNVQYTPLSYCWGPLPLPSNSEKLNFIDGIKTIGGHGDPTNKEGLAVHMYAANESMEQIAFVNNDGDFLIVPQTGRLDIQTELGRMVVRVGEVCVIQAGIRFRVSLPDGPVRGYIHEIFGTHFELPELGPMGSNGMAHPRDFEIPAASFDIDSSDWQIISKLAGNLYSYQQTHTPFDVVAWHGNYAPYKYDLSKFVSVACGLKEQLDPTVYTVLTARSKIPGVSLTEFAVFTPKWLNTQNTFRPPYYHRNMATEIGGLIYGKYRGSVKDMSPGGLSCDNSYMPHGESYEVFKKATTATLEPELAGEGALGFMLHLSSHFSITKFATERHPDIKPQKPHFWENVRGQFLNHIAHVNEILVAAGRPKLGDGAPAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZS4</accession>
    <name>A0A3D8SZS4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_01174</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZS4"/>
    <dbReference type="OrthoDB" id="2102561at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW91780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="118" mass="13317" checksum="24AFFA3D92784810" modified="2019-01-16" version="1">MTTEEACHKVSKPDGSEFANAYIYPESVFAPMQEEFLAHLHRTPNAITPDQYATGVVREILKRSPAVWFWFGASSGTIRMIDALLPRSCWDWLFGRYFNLNKLTESPAQVGSSDSSIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0E9</accession>
    <name>A0A3D8T0E9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Mediator of RNA polymerase II transcription subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 8">Mediator complex subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="primary">MED4</name>
        <name evidence="10" type="ORF">BP5796_01295</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the Mediator complex subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0E9"/>
    <dbReference type="OrthoDB" id="1929813at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019258">
        <property type="entry name" value="Mediator_Med4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13208:SF2">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10018">
        <property type="entry name" value="Med4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0010">Activator</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="139"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="253"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="253"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00031257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW91901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="316" mass="34676" checksum="DAB67FA90490B50B" modified="2019-01-16" version="1">MDKIIDNRFERVEKALATLINSISTYNPSPALANDLVTADVELSKGLQQLSEHQSNHAKILSLRATSTALDAQIRDTLTLLTTTRAELLATPATTFQSATNPVSYSDLLSYARRISKFTLPASFREAEVAAAPAVIPETTDTSVGGNSTPKDAQTNGSLSNMSTTNGAGESQSANTAMEIDGETGASQAQISSQDTTLPIEWQQYLDTNTGVQFAPWPSEETIRRGALASIQILTDQGIDLESFDPAKSAELEAERQRIEEENERAREEEKARLEEERRKEMERRMSISGAGSAPRMEEQKPKVFQLEDFEDDDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0J0</accession>
    <name>A0A3D8T0J0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Glutathione S-transferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_01413</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GST superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0J0"/>
    <dbReference type="OrthoDB" id="422574at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03048">
        <property type="entry name" value="GST_N_Ure2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040079">
        <property type="entry name" value="Glutathione_S-Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44051:SF3">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR URE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13417">
        <property type="entry name" value="GST_N_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00019">
        <property type="entry name" value="Glutathione_Transferase_(cytos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01151">
        <property type="entry name" value="Main.2:_Nu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00358">
        <property type="entry name" value="Main_(cytGST)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GST N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="3">
        <location>
            <begin position="90"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW92019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="25413" checksum="AB13E5FCCF18EFF8" modified="2019-01-16" version="1">MTQPIVLHGHTSGPNPWKVAIILEELKIPYELKIVDFADIKKEPYTNINVNGRVPAIEDPNTGITLWESGAIIEYLVETYDKENTLTYTTSPEKYLVKQWLHFQMSGQGPYFGQAAWFTKFHHERLESPTKRYQDEIVRVVSVLDKALTGKKYLVGNKCTYADLAFVTWDSMLPFIFGDKFATLNFEKNYPAYFAWNKNLTERPAVQKITKDKQAAMAKGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0T4</accession>
    <name>A0A3D8T0T4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidase signature (AS) enzyme-3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_01425</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0T4"/>
    <dbReference type="OrthoDB" id="6428749at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF151">
        <property type="entry name" value="GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidase" evidence="2">
        <location>
            <begin position="28"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW92031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="449" mass="48119" checksum="2B94946FB84485CA" modified="2019-01-16" version="1">MAEPYRLTASQALGLMKKGDLTVEDYAKSLLARIKARDEEVKAWVYLDPDFVLEQARKLDAIPADQRGPLHGIAVGVKDVILTKDMPTRHNSGIYADTPAPLVDAAPIITLRAAGALIFGKTTTTEFASTSDGGPSCNPHDKNRTPGGSSSGSGAAVGDYQVPIGLGTQTGGSTIRPGSFNGIYAFKPTWGAISREGLAQYSVTCDTLGLYARSAEDLELLSSVFQLADDEPVPAEPFSIKGSKIAFCKSPVWAKAGPGTQKAWETAKALLTQQGATVEEIELPEDFAKIKQWHSQVLAGEGRTSFLGSVLIPRVDYLLGKDKMHKMLHGHVENSSKLSRKAQLESYDGCARLRPVWDDIASKYDAVFTPSVTGEAPLGIGNTGDASFCSMWTILQVPCLNIPGFAGENGMPIGLTLVGPRYHDLHVLHAGKAIGDVFEKEGGWEMKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T128</accession>
    <name>A0A3D8T128_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C2h2 finger-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_01525</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T128"/>
    <dbReference type="OrthoDB" id="427030at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051059">
        <property type="entry name" value="VerF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626">
        <property type="entry name" value="MIP31509P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40626:SF11">
        <property type="entry name" value="ZINC FINGER PROTEIN YPR022C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Xylanolytic transcriptional activator regulatory" evidence="8">
        <location>
            <begin position="497"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="13"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="621"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="34"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="65"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="134"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="147"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="178"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="630"/>
            <end position="644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW92131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1032" mass="115577" checksum="C77B1E443EC5CA82" modified="2019-01-16" version="1">MTSVLAAHTVPFPKPSIIGQMDSGSMAQIQDSTIQRRREVKMERQEVKMDDKSRGRQWSRPKEESVDEGAEASAEEAHEGHSSGPESGPTRKRRRSRKGLDKKFECPTEGCGKSYSRAEHLHKERHFAKGSQLSRKDSQLRRDSEANENGSTLEYTSSSPEIMRPNIASSKPHPGKAQYQSPREINTSPFSPSAISSAGNYTSMNASTKMETSGQAGTFRRSHSDSIPRNNDSQQYTHGDRQQRHASFGVSDAKTADFSKPALQAAMDTYGLPSAANAHSYSDSHPSPQQVFVSQQNFTPFSLPPSGFTTAPTNAIPTRDVEPSYPTSMSLDYPNQQSGPDMMLLDQMNAPNTMPVFGGDSYNRSPFGVSEDFIAYLFNNPQVDIGMGHLSQQGFPNYTDTNSQILAYYANDANLGGLFSPGQMQQPHPMALTSLLDTSLPETVISEEKSQAIVDFIKERFNETGHSPVARQKEALLEGDRSEGNHMLSRKMMQTYIGSYWYKFSEQIPILHKPTFSPDRTPNLLLIAMMAIGASCLDKMHGHEVTQAGAELSNFLAWHLRWEIFSDYHFRPPAKLWVFQALLLLELYEKMYSTRTLHERSNIHHATTIALMRRGSSLIGRSALDSPPSVRDDKQGANESRHSSESGANTPDEWWNHWITNEATRRAAFAAFVIDSTHATMFGHSTSMVAHEMRLPLPCDESLWSATNSAEVARIEAGLHANGVKPVSFIEGLKRTLNGQEVRTNSFGRTILMAGLLSVSWHMHQRDVQVSTLGVSQALGGRDRWRGTLTKAFDLWKQDFDRSLARTSDIHGPYAYSRDKDENVVFESRTVLHHLAHMAMHVDIINCQIFARATRVLGRTIGSQDLSTAQRHMKDVWAPTAKARDATYYALQFLRITLLPEGTEPQKARQYDHIDPPFEYSAREDVLLNRPWVMYFAALIVWSYAFALEGPTTAPTPGPYDFDAQVRDMRHYLRNMANVHSPEDLKHMHGFNGCTGLLMVLRSVFEKTRWELLHEAALLLTNCIQLIGSPAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1J8</accession>
    <name>A0A3D8T1J8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_01837</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1J8"/>
    <dbReference type="OrthoDB" id="2260257at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018466">
        <property type="entry name" value="Kre9/Knh1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10342">
        <property type="entry name" value="Kre9_KNH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017545196" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="3">
        <location>
            <begin position="38"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="3">
        <location>
            <begin position="170"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Yeast cell wall synthesis Kre9/Knh1-like N-terminal" evidence="3">
        <location>
            <begin position="254"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF10342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW92443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="579" mass="60926" checksum="F9FAA684C4685B81" modified="2019-01-16" version="1">MSWSRWNILLAFLAALNSTLGQTVDTLTTSVNPPPVGGEPFTITWTTSTQWPEITIALNYYFSLTTTQNIIEYSTFIATNITNTGSFIWNVPLDLAKGRYSFSLRVGIASVLTTSTSGIFTYAPPADYTPTPTLSIAQTIACITPNSTAAAPTGTNAFFNPANGGYARFRAGYTGIFEWVPTTSGTVTLLCTSEQENQNDPPPVTTTIASKISNSGTYAWTPDASLASSSCAFKSYYIAMYFLIQPGNPPPVLGQSFDVTWSPNDATAVSLIIFGGSAPGLTVNVSIADHVANTGSFTWDVPANQYPLQAGYWTLGIFNDDTGNRDATRDFVIDAETAQTCSGYGSMVQYSPTTTNGLRTASTSSRIHTPNTAFAAGVYAQDLEITSCTTSVEPRYTSIEVSQAVISFAVVGCGSSTSSATASTLQIGTCKSDFQLFSLSGQITSVCCPSYWSTSALVASSIYCFTTTTTPSTVTLHAKRSLVRKTNSANPTVVLQNIVFAQAGIMTASNSGTSSALQTSSQTASGSIAASASATKKSAAANGVPKLEMVSLLTLTALTPLFLITGHATSLLEPQGYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T1R9</accession>
    <name>A0A3D8T1R9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Amidoligase enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_01755</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T1R9"/>
    <dbReference type="OrthoDB" id="412402at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022025">
        <property type="entry name" value="Amidoligase_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36847:SF1">
        <property type="entry name" value="AMIDOLIGASE ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12224">
        <property type="entry name" value="Amidoligase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW92361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="421" mass="47693" checksum="561AA67640D9FA02" modified="2019-01-16" version="1">MADYNPGITTIRVLGTKNTWTVKMATALSYGVELEMLIALNQDPFKRKEEQGNRTQYIQPREGMQTGELLRRHIINTLETGGIACYPFGIDGGFNKWSIVSDSSVTAMKHEHNFIWNSIEVISPAYYIFDDTLNDIRKTCRLLAENYMIHINETAGMHVHVGLGHQRFQLGHLRRLLAFFWGFEEQLNTLHPEHRSAENCGWARSLREQSIYANRSTTAVQKAVLPGIEEGIRYFLGQRFGSTRDIAKEAGGFDGNGKTMAYNFSSIALEEPLKHTIEFRQAAGTIDEDEIVTWIRTCVGIVDFCRCVDGSEAFDRVISLAREKDSPDKVNVIQLLRRMGLGDQADFYKERGLYFNLQKQSLPSFDDDGFVHLNDDREPSPAEGDFQLPPNAFNLSSLTSKVSSSHTERTPTSEEFEEISL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T2G3</accession>
    <name>A0A3D8T2G3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Argininosuccinate synthase</fullName>
            <ecNumber evidence="3">6.3.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Citrulline--aspartate ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_02015</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the argininosuccinate synthase family. Type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.5" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T2G3"/>
    <dbReference type="OrthoDB" id="1688907at2759"/>
    <dbReference type="UniPathway" id="UPA00068">
        <property type="reaction ID" value="UER00113"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004055">
        <property type="term" value="F:argininosuccinate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000053">
        <property type="term" value="P:argininosuccinate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006526">
        <property type="term" value="P:L-arginine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000050">
        <property type="term" value="P:urea cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01999">
        <property type="entry name" value="ASS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000019">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1260.10:FF:000003">
        <property type="entry name" value="Argininosuccinate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1260.10">
        <property type="entry name" value="Argininosuccinate synthetase, chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00005">
        <property type="entry name" value="Arg_succ_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048268">
        <property type="entry name" value="Arginosuc_syn_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048267">
        <property type="entry name" value="Arginosuc_syn_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001518">
        <property type="entry name" value="Arginosuc_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018223">
        <property type="entry name" value="Arginosuc_synth_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023434">
        <property type="entry name" value="Arginosuc_synth_type_1_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024074">
        <property type="entry name" value="AS_cat/multimer_dom_body"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00032">
        <property type="entry name" value="argG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001770">
        <property type="entry name" value="PRK00509.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11587:SF2">
        <property type="entry name" value="ARGININOSUCCINATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20979">
        <property type="entry name" value="Arginosuc_syn_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00764">
        <property type="entry name" value="Arginosuc_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69864">
        <property type="entry name" value="Argininosuccinate synthetase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00564">
        <property type="entry name" value="ARGININOSUCCIN_SYN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00565">
        <property type="entry name" value="ARGININOSUCCIN_SYN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0055">Arginine biosynthesis</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginosuccinate synthase-like N-terminal" evidence="12">
        <location>
            <begin position="5"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="domain" description="Arginosuccinate synthase C-terminal" evidence="13">
        <location>
            <begin position="178"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00060987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF20979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW92621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="412" mass="45743" checksum="C666E048B48D6467" modified="2019-01-16" version="1">MAKDKVCLAYSGGLDTSCILKWLLEQGYDVVCFMADVGQEEDFAAAKEKALKIGASACYIEDCRKEFIDELCFPAIQCNAIYENTYLLGTSLARPVIARAQIAVAQKEGCFAVSHGCTGKGNDQVRFELAFYALQPSIKVIAPWRMPVFYNRFVGRNDLLDYAAQVGIPVSSTKSKPWSMDENAAHCSYEAGILENPDTTPPQDMWKLTVDPMEAPDTPEDFTLVFEKGLPKKLISKGKTITDSVELFLEANAIARRNGVGRIDIVENRFIGVKSRGCYETPGLTCLRAAHIDLEGLVLDREVRALRDQFVTFNYAKILYNGLYFSPEREFLEESIIASQKNVNGTVRCRVYKGSFSVLGRSSDTEKLYDESESSMDEIGDFDPAATSGFITVQAIRLKKYGAAKEAKGERL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T6U2</accession>
    <name>A0A3D8T6U2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative monooxygenase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_00028</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAD-binding monooxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T6U2"/>
    <dbReference type="OrthoDB" id="74360at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004499">
        <property type="term" value="F:N,N-dimethylaniline monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051209">
        <property type="entry name" value="FAD-bind_Monooxygenase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020946">
        <property type="entry name" value="Flavin_mOase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877:SF7">
        <property type="entry name" value="FLAVIN-BINDING MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42877">
        <property type="entry name" value="L-ORNITHINE N(5)-MONOOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00743">
        <property type="entry name" value="FMO-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW94265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="583" mass="65362" checksum="8040D9B8B1591D59" modified="2019-01-16" version="1">MGSIQDNPTPFPFQHRSVDSPRKLRIAIIGAGVSGIGLYIRLRQYVPSAELQIFEKNSDVGGTWFENQYPGVACDIPSHVYQYTFEPNTQWSKFFSGGPEILDYVRGVATKYGVQKNVSFNTRVFGATWNEAQGNWTVKIGDAVQTGRTESQTFDVVISAVGNLNKWKYPEIEGLHDFEGKLLHSATWDPTWSVSKHSGTASGSYRVRDYTNKNVALIGAGSSAIQILPHLQKKCTEVFHYTRGKTWVSEPFGGEATQATIAGNKDSGNYSYTSEELRKFREDPEYYWNYRKNIERFINLDHPCLFAHEEASIASKQRIIENMKTKLAKKPEIYAALEPEFTPGCRRLTPGPGFLEALVEDNVHFTNSKIVRVTKDSIITADGTIQKVDAIVCATGFDTSFLPRFPIKGSNGILLANQWSSHASAYLSTAIPNFPNLFLLGGPNSATGGGSLLIIFESIIGYVVKCVQKISREHIKYMAVKPSALRSWERYMDAYFPGTVHVENCTSWYKAGQKDYKVVGLWPGSSLHARRTLEFPRWEDYEYVYPEAQDSLGWLGDGWTVADREKGDTASYLDEVDYPPVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T766</accession>
    <name>A0A3D8T766_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nuclear localization protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_00117</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T766"/>
    <dbReference type="OrthoDB" id="5598844at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016586">
        <property type="term" value="C:RSC-type complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013933">
        <property type="entry name" value="CRC_Rsc7/Swp82"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597:SF3">
        <property type="entry name" value="CHROMATIN STRUCTURE-REMODELING COMPLEX SUBUNIT RSC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22597">
        <property type="entry name" value="POLYCOMB GROUP PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08624">
        <property type="entry name" value="CRC_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="66"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="111"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW94354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="512" mass="57176" checksum="17043AB996381148" modified="2019-01-16" version="1">MGRRPGRAAAKNAAAALKNTPQTYDEDLEDEEMQEAPTSDVGTPQDPEEEDGGDDDGTPAQESEPPSGPSTPVPEPVKRRRLGRPPKNKPPGWDDADANDRVASETGTPRGRGRGRGFGRGGRWKNRGGPSHVTQQPIDKEGNMMDIIDDEVDLPEDPVGETKVDKFGHLQGDREYRCRTFTVQGRGQRLYMLSTEPARCVGFRDSYLFFAKHKRLYKIIIDDDEKRDMIERELIPHSYKGRAIGIVTARSVFREFGAQIIVGGKRVIDDYEVAKAKAEGVIEGELADPNDAFKQGEAYNKNQYVAWHGASSVYHSGAPTVPQPIGKAADSKKRRVMINDVNWQYEHAREASRFNANLGAIRRQNLSGIYDPHTNVMHYPKIMQPTHARWEQIDDHAVQSSHDPDTKMHGHKDTIFTAVPSIYSRNYMIVDTVYESSPSTNFGLPGLGTASTDLGFNGLSSVPDDIRAELPPECLKAFEEALAKERRWKSKWTSEEKDTNRRAPKIDKGLLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7A1</accession>
    <name>A0A3D8T7A1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Signal recognition particle protein Sec65</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_00235</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7A1"/>
    <dbReference type="OrthoDB" id="2190947at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006617">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.56.30:FF:000003">
        <property type="entry name" value="Signal recognition particle SEC65 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.30">
        <property type="entry name" value="Signal recognition particle, SRP19-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002778">
        <property type="entry name" value="Signal_recog_particle_SRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036521">
        <property type="entry name" value="SRP19-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01922">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69695">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0733">Signal recognition particle</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="261"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="266"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW94472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="291" mass="31653" checksum="59BF9A64C6DB29AB" modified="2019-01-16" version="1">MSHARIEEVEDSDLDASDPSEGDISDVNSDFDERDILKARAAPSRTTNDAHAAKSALISPENIPSAQRPGQPNINNIAAGTPFQATEDESKYKDFQCLYPVYFDKNRTRAEGRRVGKELAVENPVAREIANACARLGLESCFEMMKTHPKDWGNPGRVKVKLKGGRNSMVKNKHHLYILVAQHLQANPTTIGHSTQIRMPGLPVPDPKKPFPHPAVPKGWKLNSIVPYYSAAMSGGGVSDNMFRDMMQEMQGAGMGGLPGMGGMPGMMEGAAGASGQVEKKEKKDKKKKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7B6</accession>
    <name>A0A3D8T7B6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Histone acetyltransferase</fullName>
            <ecNumber evidence="3 14">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BP5796_00192</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z. Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac. The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination. Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins. In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 14"/>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7B6"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990467">
        <property type="term" value="C:NuA3a histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16866">
        <property type="entry name" value="PHD_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="16">
        <location>
            <begin position="182"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="MYST-type HAT" evidence="17">
        <location>
            <begin position="523"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="246"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="368"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="850"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="914"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="17"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="65"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="141"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="866"/>
            <end position="889"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="918"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="941"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1019"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="1056"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="12">
        <location>
            <position position="699"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDW94429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1095" mass="121210" checksum="A21C848384F7DF78" modified="2019-01-16" version="1">MAAEVLMQEELHRSMETSEEDAEFEEDDELGTPMMEDNEAEYAANAQLHNGLVEHSREDEATGNAEDEEDAEEGEEGLEDDEDDALTDEDAEGEEDEDAVMERQGDEEEDEDEDPETAGAVKIIPGQMADDDEDAMSRSSEEEEEDFAASGGEDEDKDSTDAEAELDWEANAADEEEELTNPNRCIFCYQDEENDPSEEFEMYLTCDVCADNSHRQCARDAGALEAGDEAETWRCPNCVRNQLEPAHETEDAATTEGTFDSTTRRVSSNRIAGDLLPSQRGSIKPDSHSVFNTLIAPDDPLDGSRFLRRRKSSAADVDADEATILRRRTRDKEVISNIHVTDSHIVHEDAAATLDAAAAILTNGIKKDESISPRTSRSLRPKPSQPPASLLEKTATSIRVVIRLDPVELRHIQSVPPKPKKKKASRSNAAHNIVVPSVHVHHSYTQPFYALHDKEIDEFKSKPYGGILADTEAETTNTLPKPENRKYFDEARQKSEAEWQANVTAAAATAVAVGMKRARKVSGPASQIEYIEFGANQIDIWYAAPYPEEYSRNKALFICEFCLKYMESPMVAWRHKTKCPWKQPPGDEIYREGKISMFEVDGRKNPLYCQNLCLLAKLFLGSKTLYYDVEPFLFYVMTEYDDHGYHFVGYFSKEKRASSLNNVSCILVLPIHQRKGYGHLLIDFSYLLTRHERKTGSPEKPLSDMGLVSYRNYWRLIMSYYLGRLNPGDSVPSIQKMADETGMTPDDIVSALEALGAVIRDPLTGTYAIKLKSERYDQVVRQHEAKARHYAKLNPRSLTWTPFIMGRGNASYFELAPPLNTVAPREDEEDLAVKDPLSTSKKRDFAELNGASDEVDPIANPLGMLPTTSTDYVKSEGSTRSGSTLNGSTKKTDYYEVASNIPATRFEVFPSVPGARKSTVNRNSVSRARSGLAAATPTPNRNSGGSSSRRASSDRPSSRRKSTGRGPGRWPKGSKKSDFGLNNNSGPGLAPRSNKRSRLGQEVVLGEGEDHEHAIDDGNASEEDEDAILYETPDTRKRNSRSTGRGLGKPPLGKPSGKGKGKPGSGGKSLLLDPDGDAEMGEFVVGDLDAEGEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7T9</accession>
    <name>A0A3D8T7T9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphatidic acid phosphatase type 2/haloperoxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_00347</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PA-phosphatase related phosphoesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7T9"/>
    <dbReference type="OrthoDB" id="8907274at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046839">
        <property type="term" value="P:phospholipid dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006644">
        <property type="term" value="P:phospholipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03390">
        <property type="entry name" value="PAP2_containing_1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.144.10:FF:000042">
        <property type="entry name" value="PAP2 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043216">
        <property type="entry name" value="PAP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165">
        <property type="entry name" value="LIPID PHOSPHATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10165:SF154">
        <property type="entry name" value="PAP2 DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G09730)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00014">
        <property type="entry name" value="acidPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="467"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="8">
        <location>
            <begin position="269"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="536"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="543"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW94584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="557" mass="59995" checksum="EFF8CD61D56DBB90" modified="2019-01-16" version="1">MGDGRWLETCVRVREVRCQAEAEEADGESEKAWPCACVVVIGDAARSRLQPKLPGGMSLATLHGRAPCGCASKRRRRRSQKLRERTPARTGPGNCSYLCCPSLGAIHGLVEGHRCSTNGPWLFIPPPEGYPYKDLRPTSLAAASPTLHPNNVNMLSTLTSRGGGRISAALVLSYVFDWIWIIIAAAIGGVFSGRSPNKHPFSVVDLSISYPFLKNTVSTTTLFLVSLVAPAIIVVIVALCLVPGPTVPKSTPKGLIWRRKLWEWHTGWLGLALSLATTFVITNGMKNLFGKPRPDLLARCNPDVANVAKYAVGGYDNVTGGVLLVSHAICQSTDTSVIDEGFRSFPSGHSSFSAAGLVYLSLFLASKLAITIPFLAPVAYNAARYAAFPSRVRRPETQHRTEVSADKTSSAGLETYPSGHNDAIIAARNQAAAPPLYLLVLVLIPFFTSIYISATRWSDFKHQGFDILFGYFIGTVTSIFAFRFYHLPMSQGAGWSWGPRSRDRSFWAGVGVGNYAGGREPSSVIKQDQDVELGATEHAGAASNGQANTIQSPTAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7Y9</accession>
    <name>A0A3D8T7Y9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Class II aldolase/adducin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_00397</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7Y9"/>
    <dbReference type="OrthoDB" id="2932980at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016832">
        <property type="term" value="F:aldehyde-lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019323">
        <property type="term" value="P:pentose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.225.10">
        <property type="entry name" value="Class II aldolase/adducin N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050197">
        <property type="entry name" value="Aldolase_class_II_sugar_metab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001303">
        <property type="entry name" value="Aldolase_II/adducin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036409">
        <property type="entry name" value="Aldolase_II/adducin_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22789:SF0">
        <property type="entry name" value="3-OXO-TETRONATE 4-PHOSPHATE DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22789">
        <property type="entry name" value="FUCULOSE PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00596">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01007">
        <property type="entry name" value="Aldolase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53639">
        <property type="entry name" value="AraD/HMP-PK domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0456">Lyase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Class II aldolase/adducin N-terminal" evidence="3">
        <location>
            <begin position="13"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW94634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="290" mass="32291" checksum="73985D137661828F" modified="2019-01-16" version="1">MAVGLLTHPQVRSMLITANHILHYNKVLDAYGHISVRHPYNPNVFIMSASVAPALVSCFENLIEYHVADASPVEPDVRKGFQERFIHSEVYKRYPEINSVVHSHAEAVLPYTMNGVPMQPAFHVAGFLGTHTPVWDISALYHPDDQMDMLVNSIAFGSSLAAAFSTDEVQAHKHDHNVVLMANHGFSTVGRDIQQAVYRAIYTTVNASVLSNAIQLRNAFTASEQPTAELRCLTSEQTIGAMKFNDNSQSRPWELWVREVEACPLYVHQESQAWGEEAASKHRSGAQKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7Z6</accession>
    <name>A0A3D8T7Z6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_00450</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. DCP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7Z6"/>
    <dbReference type="OrthoDB" id="18996at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140933">
        <property type="term" value="F:5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03672">
        <property type="entry name" value="NUDIX_Dcp2p_Nudt20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1050:FF:000003">
        <property type="entry name" value="Decapping enzyme Dcp2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000003">
        <property type="entry name" value="M7GpppN-mRNA hydrolase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1050">
        <property type="entry name" value="Dcp2, box A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007722">
        <property type="entry name" value="DCP2_BoxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036189">
        <property type="entry name" value="DCP2_BoxA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044099">
        <property type="entry name" value="Dcp2_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114:SF17">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05026">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01125">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140586">
        <property type="entry name" value="Dcp2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="94"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="308"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="415"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="654"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="733"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="849"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="892"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="654"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="735"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="746"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="896"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="912"/>
            <end position="931"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW94687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="956" mass="104397" checksum="389941008710C904" modified="2019-01-16" version="1">MTDIRTLEDWLDDLCARFIINLPETDLSSVQRICFHVEEAQWFYEDFIRPLDPTLPSMTLRTFCMKIFAHCPLLSVFSHENRITAFEEFMKYKSRIPVRGAILLNAAMDSVILVKGWKKGAGWSFPRGKINHEEDDLVCAIREVYEETGYHIQEASVDRQNDQIQKNLKEQHVMFFLIRGVPMDTHFETQTRQEIGKIQWWPLHKLPGWRGSPQHHNQADVAVNANKFYMVAPFLRPLREWIKRQRQKDAKQSTDHYMSNGPAVEDLLTEDDQVTDTNASGPAYGQVPKTTTTFEGTNAALTRLVKSQAPTQGLQAEGMKATQASDSKPNPQDLLALLRGNNSAPVNAPPHTPLDHVFTNAPVPQTPHHQQPRPQHFSSMPPPPNFPFYPTMHASVPFQGQVPQNFQQGFLGHQQMHHPGAIPQPVSHPLPRQQVQRPQKAHSYQPQLVHPQPLPPNVQKAVFSGLVHTPSLPQSSQPQASSYQSNPNSNFAAQNPQFPGLHAPMVPPMVKQSSKLTSHSLALLNAFKRQDSAASNTSNLASRSSTQIGTHAIDIQPQELYGETASLPQATVSQTIKSGTTIANPAANTTPVPNLLDMFKDPGSAVSDSGAGATQKSALLSLFKSPATQPAVTSSVPAAHESHRSALLGLLNNSNPTVHQSQTLNRPLPTSSSARPPHMAPSAVELSAVEPLAKASTHSVGSDKAALHNELPAVVPEMNPETNLPFRATAILARPSQSQNSPNVNRAEREPTTPRASERVRPGKQPIGVHGSNKKTNASKKPRPQKSPERPFQPQILKRPQPEATAVSETSISPAPVLATVPVSPPVMSQGSDHKQALLSMFGQSAMTSPPLNSASIPYRPSSNQNSVPGEQSQKLLSLFAKQPAATNPLLKAQGNEETTSTHSVDTAFDPASRSRVGSLASGAASSRRGSQTPISPADKGFLLNYLDNVAKGSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T845</accession>
    <name>A0A3D8T845_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidyl-prolyl cis-trans isomerase-like 2</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Cyclophilin-60</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="15">Cyclophilin-like protein Cyp-60</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">RING-type E3 ubiquitin transferase isomerase-like 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BP5796_00490</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2 22">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T845"/>
    <dbReference type="OrthoDB" id="407558at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01923">
        <property type="entry name" value="cyclophilin_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16663">
        <property type="entry name" value="RING-Ubox_PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000079">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000014">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase cyp65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026951">
        <property type="entry name" value="PPIL2_U-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF1">
        <property type="entry name" value="RING-TYPE E3 UBIQUITIN-PROTEIN LIGASE PPIL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0697">Rotamase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="19">
        <location>
            <begin position="40"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="18">
        <location>
            <begin position="327"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="235"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="484"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="235"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="251"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="484"/>
            <end position="510"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00003697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00020592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00030661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00030942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RDW94727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="575" mass="63309" checksum="515812B280E5591E" modified="2019-01-16" version="1">MGKGTDKLYITHSEWSSSDAYSASAGSNVSQKAPNGANFKRLPFNFCAASLQPFKNPVCTLEGTIFDVEVISQWLAKHGTNPVTGLPLKDKDLIKLNFARNGDTDAHDGGGGDGDGKGEMVDPVTFKVFTDNTHIVAIRHGSEANVFAWETVERLNIKAKMWLDLVDDREFGRSDIITLQDPQNIESRDLSKFKFIKEGETVLTKEQIEDRQKGSVNIDALGRVGEKVLRAKEAVEKARRERENGGDVNRSKTLAKSGTANSVARPSMIQDKKVAYNAAQYTTGKAAASFTSTGLTPETSGERALLTDEEYMLRPKRVKIKGYARIETNFGSLNIELQTETAPRAVWNFVQLSKKGYYNGVTFHRNIRNFMLQGGDPTGTGKGGTSIWGKNFQDEFDGPLTHDSRGVVSMANKGKNTNSSQFFITYREAKHLDRKHTIFGRVVGGLDVLSKLENVPVGASDRPETPIVMESVVVFVDPFEEFQKQKREKDEAEKEKAEIKRQGGTEDDKTTWTGKRIRGDGTVMQTESSGGVGKYLKSAAAPSNGGGKTVENDEMDDMPVKKKVKSAGFGNFDSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8Q0</accession>
    <name>A0A3D8T8Q0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Chromosome condensation protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_00668</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>fluoride(in) = fluoride(out)</text>
            <dbReference type="Rhea" id="RHEA:76159"/>
            <dbReference type="ChEBI" id="CHEBI:17051"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:76160"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8Q0"/>
    <dbReference type="OrthoDB" id="409792at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903425">
        <property type="term" value="F:fluoride transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003691">
        <property type="entry name" value="FluC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259">
        <property type="entry name" value="FLUORIDE EXPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28259:SF1">
        <property type="entry name" value="FLUORIDE EXPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02537">
        <property type="entry name" value="CRCB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="96"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="261"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="308"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="338"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="437"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="49"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="49"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW94905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="464" mass="50330" checksum="677E00E9175DC543" modified="2019-01-16" version="1">MDNRQSSLPRPGRLRRSSNSYNALSDYHNLDELAVPAPVLDPDEERLRTVGSLEDRNDVNKEGNGGLDAQRTPTAQGASAEGTGSDYEVSGAATQLYTISYLIFFSLLGTLARLGLQTITFYPGAPIVFSEVWANFGGCLIFGFLSEDRMLFKYEWGRATYDQAIARAKARQHDEENGASFEKPDGMIAAKRAHAATKKTIPLFVGLATGFCGSFTSFSSFIRDAFFALSNHLPTPLDHPADYTISSTTSSTVSRNGGYSFMALLAVLIITVALCMAALQFGAHLAILSEPYTPSLPFLPARKVLDPVFVFLAWGSWLGAILLAIFPPDAVTWRGRAVFALVFAPVGCLSRFYISLFLNRRIASFPLGTFVVNIVGTMILGLSYDLQHVPLGGVIGCQVLQGIEDGFCGCLTTVSTWIGELDGLRRSHAYRYGTASVILALSTLIVIMGSMQWTVGFSALVCKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8S1</accession>
    <name>A0A3D8T8S1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vacuolar membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_00688</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8S1"/>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025016">
        <property type="entry name" value="DUF3955"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000620">
        <property type="entry name" value="EamA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051:SF0">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23051">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35, MEMBER F5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13127">
        <property type="entry name" value="DUF3955"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00892">
        <property type="entry name" value="EamA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="94"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="240"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="404"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3955" evidence="8">
        <location>
            <begin position="57"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="EamA" evidence="7">
        <location>
            <begin position="191"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW94925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="442" mass="48223" checksum="980C60AA64B5A8E7" modified="2019-01-16" version="1">MSAHEPVVPVTMGADFTLLDGPTPGQDEESSASPVRSSKSPSGFRAGVGLENVARRTLGIILLLVTVFLWTASNFLASYIFADNTFSKPYFVTYINTSFFAISLIPILFRIAHAHGFSNVRSSAVDYWQGQVDKYKRLSKGLGDDAISASAARLLGDDEAAEQLPVSGLLREPESMLSVRETSWLSLEFCLLWFIANYLVAACLEYTSVGSSTILTSTSSIWTLIFGSMVHVESFSVRKLIGVLASFIGIILISSVDLSGKDNDSNRGNFPHKSQAEIAVGDAMALGSALMYGLYTVVMKKRIGNEDRVNMPLFFGLVGLFNVLFLWPGFLVLHYTGIESFQLPPTGKIWTIVLVNSVSSFVSDYCWAYAMLLTTPLVVTVGLSLTIPLSLVGQMVLSRQYSSALYWVGACVVVCSFIFINHESTEEPEQSGNTLQQVPLEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T993</accession>
    <name>A0A3D8T993_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trafficking protein particle complex II-specific subunit 65 IgD3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_00341</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T993"/>
    <dbReference type="OrthoDB" id="5345392at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055420">
        <property type="entry name" value="IgD3_Trs65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024662">
        <property type="entry name" value="Trs65"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28159:SF1">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX II-SPECIFIC SUBUNIT 65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12735">
        <property type="entry name" value="IgD3_Trs65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trafficking protein particle complex II-specific subunit 65 IgD3" evidence="1">
        <location>
            <begin position="416"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12735"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW94578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="596" mass="65618" checksum="070DAFCFF207AF36" modified="2019-01-16" version="1">MMELAEIESTPRGSLEFVESSILDTLIPLSTSLDIEDALKGSVERLDEGHDSPLAAIPRRQALFFDETVNVYVILQTPYFDERTLRSYLGRLIITLEAQVVNTVAENYEGAPPSETVYTGSVQDTEDPIIVVQGPNEAGSEGHILVVWKMSAFLGRPRLRLQNPSIVFAASASLKPAEQLEADALKEEYLPSQMPSGLNLLEAFSNELVLGSVKPHLSALRVSRVAPLTQAAKDLRRPLKNMSRRTFRVYPAINARVRYSRPSTTPKTPCVITSLDVDITPYANCTITLTEVNVTMSGGFVEDLNHVQGLSLPIDCRPQDDVTFLYRVEPDGMDLTNRSQLRTLEISVLAVVDLVEGVCQPIISMKWTTSLDFTPPVNPGYGPPTQPIVRQHRPSQLSLGSSFDNIPTVSSFAAGRPDSLLSMEFTTRQERTSSIPDFGVTMTFTGPSAENTIYPGKRFNWSVFVVNRSDRSRKLAIAAIPRRKRMETRVTRPLSTGYGSSQKDVKVADAVLDENIVYAMQRNSILDSAEVVCLSTDIRVGPLAPSACHTVELTFIALKEGIVSFDAVRVVDLGTQEHVDIKDLPNIIVSKDPKAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9B7</accession>
    <name>A0A3D8T9B7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Ribokinase</fullName>
            <shortName evidence="12">RK</shortName>
            <ecNumber evidence="2 12">2.7.1.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BP5796_00888</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-ribose + ATP = D-ribose 5-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13697"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:47013"/>
            <dbReference type="ChEBI" id="CHEBI:78346"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.15"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate.</text>
    </comment>
    <comment type="activity regulation">
        <text evidence="12">Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Carbohydrate metabolism; D-ribose degradation; D-ribose 5-phosphate from beta-D-ribopyranose: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="12">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the carbohydrate kinase pfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.15" evidence="2 12"/>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9B7"/>
    <dbReference type="OrthoDB" id="415590at2759"/>
    <dbReference type="UniPathway" id="UPA00916">
        <property type="reaction ID" value="UER00889"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004747">
        <property type="term" value="F:ribokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019303">
        <property type="term" value="P:D-ribose catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01174">
        <property type="entry name" value="ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01987">
        <property type="entry name" value="Ribokinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002173">
        <property type="entry name" value="Carboh/pur_kinase_PfkB_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002139">
        <property type="entry name" value="Ribo/fructo_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011877">
        <property type="entry name" value="Ribokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584:SF166">
        <property type="entry name" value="RIBOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10584">
        <property type="entry name" value="SUGAR KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00990">
        <property type="entry name" value="RIBOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00584">
        <property type="entry name" value="PFKB_KINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 12" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 12 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="14">
        <location>
            <begin position="7"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="14"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="42"/>
            <end position="46"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="248"/>
            <end position="253"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="281"/>
            <end position="282"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="282"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="326"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="328"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDW95125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="339" mass="35504" checksum="04A8BBAB9CBF34E0" modified="2019-01-16" version="1">MGSQKIISVIGSLNTDLVTLTPYVPSGGETMTATSFSTGPGGKGANQAVATARLSQTNPHVSSDSEKSKQAPSDILVKMVGAVGADEFGPTLISSMKHDGIDINSVKVVEGTTTGVAVILVEEKTGENRILLNPGANHSLRPEDFEDISSFGTPAPDLIILQLEIPLDTVLQILNTAKRAGIEVLLNPAPAVPLPDEIYTAITHLIVNETEAALLSETTVEEVEQTGADWGRVAQKFIKKGVKNVVVTLGAKGAIFADVTNTSGQLQSGEKVKVVDTTAAGDTFVGAYALEVVRRQGNKGTPEQSFEIMSKAVQRACKAAGKTCEKKGAQSAIPWADEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9C3</accession>
    <name>A0A3D8T9C3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Mitochondrial import inner membrane translocase subunit TIM22</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_00923</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the TIM22 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Mitochondrion inner membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9C3"/>
    <dbReference type="OrthoDB" id="75343at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042721">
        <property type="term" value="C:TIM22 mitochondrial import inner membrane insertion complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030943">
        <property type="term" value="F:mitochondrion targeting sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045039">
        <property type="term" value="P:protein insertion into mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039175">
        <property type="entry name" value="TIM22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14110:SF0">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW95160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="173" mass="17638" checksum="9ADD97258CD11496" modified="2019-01-16" version="1">MNNPAFNTSGGGEMSAQDAQTQAAVKSMQTLMESCPGKTVVSGVMGFALGGAFGLFMASMQYDTPLSTNPTAANITSLPLREQLRQGFKDMGARSFSSAKNFGKVGAIFAGTECCVEGFRAKNDLKNGVIAGCITGGVLAAPAGPQAAAVGCAGFAAFSLAIDAYMRRPADSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q7E0</accession>
    <name>A0A3D8Q7E0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Prion-inhibition and propagation HeLo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_12534</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q7E0"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1020">
        <property type="entry name" value="Prion-inhibition and propagation, HeLo domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029498">
        <property type="entry name" value="HeLo_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038305">
        <property type="entry name" value="HeLo_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021084">
        <property type="entry name" value="Het-s_prion_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542">
        <property type="entry name" value="HELO DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37542:SF3">
        <property type="entry name" value="PRION-INHIBITION AND PROPAGATION HELO DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14479">
        <property type="entry name" value="HeLo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11558">
        <property type="entry name" value="HET-s_218-289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prion-inhibition and propagation HeLo" evidence="2">
        <location>
            <begin position="6"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Het-s prion-forming" evidence="1">
        <location>
            <begin position="218"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF11558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW57733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="290" mass="32460" checksum="BAC5DA25E5B8C059" modified="2019-01-16" version="1">MAEIFGTVASALSIAALFNNCVDCFEYIQLGRHFGRDYERCQLKLDTAKIRMSRWGQAVGINEDPRFTIDTPADKESQHIRAILEEIDQLYRTVQKSSARYEIDATQKDLMHFEAKELQPVARRLHSRLGVIATRRQKQTSLLKKATWALYDGKNLDKLVEQIGGFVDDLEKLLPVEDTRRRLVEMEIEEVDDEQSLTALQTAAASTDQLLSEAVTKKLEGIAGTNYAKDIRGEENAQVRVGNEWSEIASTRGVNIADQTSNRADFIAAKGTSAVQIGNSFGGRSVFDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q930</accession>
    <name>A0A3D8Q930_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Amino acid transporter-6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_12251</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q930"/>
    <dbReference type="OrthoDB" id="10062876at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1740.10:FF:000042">
        <property type="entry name" value="Similar to amino acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050598">
        <property type="entry name" value="AminoAcid_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11785:SF402">
        <property type="entry name" value="AMINO ACID TRANSPORTER (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="45"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="78"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="122"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="296"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="411"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="471"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="493"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW58321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="523" mass="55663" checksum="3247CCC3E0E8595D" modified="2019-01-16" version="1">MPQSDQSDDGAQRPLLADATQPEYGATAETAAPATSQPGTFTRNLGTIEAFGIVISIVIGSGIFTSPGSIDANVPSPGVALVIWLVGGILAWTGATTLAELGTAIPGEGGVQPYLKHIYGDVFGFLAAWTWIVAVMPATLAILSIVFIESIFSALGVTDQAGRIEHKLLSVLVLTVVSAANSISTKASTRLNNFFVVTKFVSIFGVVLAGIVVMILGASNPDRVIGGRDWLTKPWFGFRDSVNPDGSTTHWAALSQWEILGHYSTALYGALWAYSGWDKAVYITAELSAPARQLPLAINTAIPTIILCFITANTAYYILLPWDVISTTDSVAVTAITRLLGSGFGIVAAALVCLVVAGSLLGNSFIAGRMTVAAANHNWFPRFFALVGQVGANSDQNTDSPRPPKSSRSDAPLNALLLSTTLSALYILFGNFRALLTFNGLGEYSFFFLTVLGVIVLRIREPGLSRPYKPIVLIPAIFALVSGFVVVRGAVFAPFQAGIMIIVWIVGIVFYRARRTWTREVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QA19</accession>
    <name>A0A3D8QA19_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_12234</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QA19"/>
    <dbReference type="OrthoDB" id="2157530at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd05233">
        <property type="entry name" value="SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020904">
        <property type="entry name" value="Sc_DH/Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975:SF2">
        <property type="entry name" value="EG:BACR7A4.14 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43975">
        <property type="entry name" value="ZGC:101858"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00061">
        <property type="entry name" value="ADH_SHORT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="3">
        <location>
            <begin position="130"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW58304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="709" mass="79686" checksum="9105B9615CE7BDBF" modified="2019-01-16" version="1">MERPNPFDPLARGKARVVVYRSAQEQNAEKDQTGSILSPRDDPKDIRDTDTHDYLDTVPFPASRDRHSESHPRHDLSLPDDLFNLENPSTTVWPMRLLHAKTMTAYTRMTEDGSACYRSPEGITVVEPSYNILSYTWGRFELRGDSSASSLQVRGIKWRVPSIDANKAFSVDEFRDLLQQIAGEDGFVWVDVACIDQRNDSEEKKVEIGRQVGIFYRAQSAYIWLHQLSKEDLQKGIDAISYAKEARNATANDTRCIETMCQDPWFSSLWTLQEAYLRKSAILLSKTGGPVFTSPGTYATLQWVLEACGHPWAHATGYIKNVVHTAGLDRISARNPVVLLAAARYRQTSRPLDRVQGIMQVFGLNIGSDIPEPRLSQLEVELSKEINKKSPALAQAFINVDPVAADQAWRLQVGAITPAKRNHRDTFQRPGLDFTQIVPADFFHALEMTTYHKRAKITFTGDIPTFQGFSFPLESLLAMWEMELPDDQENPQLDNWMPYMNHLTHSIYMDNVNGITDTNKLRLVPFEEAFLKHNRPLILAQDLATHFPDQIRRLDPAAAQAVAETFGRLDVLINNAGFMTNALPIVDSVESEYWRTFEVNLRGVYLVTKAYLPLLLGGLKTVLNVNSVAAHNLRPEASAYGTSKLAVLILTEFLMVEGAPKGLLAYSVHPGAIMTKLAEAMPQSTFANLTHKPEMVADTIVSLTQKKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QC60</accession>
    <name>A0A3D8QC60_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Glutamyl-tRNA(Gln) amidotransferase subunit A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_12112</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the amidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QC60"/>
    <dbReference type="OrthoDB" id="421993at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1300.10">
        <property type="entry name" value="Amidase signature (AS) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000120">
        <property type="entry name" value="Amidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020556">
        <property type="entry name" value="Amidase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023631">
        <property type="entry name" value="Amidase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036928">
        <property type="entry name" value="AS_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895:SF67">
        <property type="entry name" value="AMIDASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11895">
        <property type="entry name" value="TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01425">
        <property type="entry name" value="Amidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75304">
        <property type="entry name" value="Amidase signature (AS) enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00571">
        <property type="entry name" value="AMIDASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Amidase" evidence="3">
        <location>
            <begin position="161"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="80"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW59188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="614" mass="66677" checksum="4082BEF320AE2B20" modified="2019-01-16" version="1">MIASLGDDGRFLNYPEPVEGPDVPLKRDTKSNPALTGIHLLIAVWLLEHFGWLRRLIWRNTGFNKLRLLQEYIENVEPRHNPNVVPISPKRKSEQPEPANAESAPESFRPKYYSSADYHQMYLTGELTPTAVAKALLPLIRRDISPAGPFSIGWHDSKVDMVMAAAEASTLRYKKKCPIGPLDGVPTGVKDDYDLEGYRTNLGSANEYTAKPVGGGCITSWCVKKLEESGALILGKLTMPEFGMDTCGNNPVYGTPPNPHNPQYYTGASSSGSAYAVSVGLIPFALGGDGGGSVRIPASFCSVYGLKTTHGRISQAPSANHANTCAVNGPLASDIRSLAAVYHVMATPHPTSDFPPTSPISLSVSSPSSPQRILGVPDEWISGATPRTQYLCRSMLEKLSTAYNYKLVSIKIPFLVEGQLAHAMTMLADAATLLPSTHNITAPNKVLVALGSVTPATDYLLAQKLRHLLMQHLAHLWKQYPGMIIVTPTTSCEGWPFRHPKSEFKYGLSDGDTTLKTMEYVWMANFCGMPSLALPVGFAKAEGTGEENVPVGMMGMAEWGGEDELLQWGLDAEALSEDVTRRPPIWVDVVEKAKLEMTENTNGLVSGQEALVDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QEK9</accession>
    <name>A0A3D8QEK9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mid2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_11865</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QEK9"/>
    <dbReference type="OrthoDB" id="4497263at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="236"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW60259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="33703" checksum="EAAD34696A075307" modified="2019-01-16" version="1">MTTTHPPETNSGVVTSWLPVTTAWPSVSQCSSEIYSQIPFGTNGGALAIAFDPYYAQSIDSRITCLPPAATLWWDQTQQIPAQTVTSLGPFVCPGLYTTASTSNVNGLSTFIACCPSSYTFQSVLSSGLGQCNSELSASQLFTYASFDLSATEWTIATTTISSQASVFAVHVNGYAFAASTVSSTSSTSGSQTTAAYSQATLSSTIASTSSPSSTFDTSDHTSVQASGALSTGAKAGIGIGISLVIIGLSCVVAAFLFKRRRQRKLNNSVRLDIGYIPPYPSSLSSSAATSWQEPPIMPKVWGDRVVSVHELSSTPRAGSFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QEQ2</accession>
    <name>A0A3D8QEQ2_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_11911</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QEQ2"/>
    <dbReference type="OrthoDB" id="10330520at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW60305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="304" mass="34379" checksum="56822B4FE83C190A" modified="2019-01-16" version="1">MPLSAITKYSIFSNIISRYLEIILVHWASHRYAFTMNQLIDAVDECPEESDIPSLCNSSTTLVPTPRVQSWLQQLPDEWEAADLFKFDTTRNNYNSSHTPKYVPYRLRKIGRGRTTQRRPQQSQEAISSFIHRTQYTTQHRAFKILPSNSTPPGRKRHIFGDLQNKPSENDPPTPQRESPLKHKQSFDAIGNLRNISKGHGYGMEVVSELNLEVDAESIPRSNGSTPLKTTLFYQHPPPLSNPSATLVLPSRSSSSNRSDGLHAGRWSSETPRSENPIKMSGFQMPNLPILLKESTLSDFPPPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QKZ7</accession>
    <name>A0A3D8QKZ7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">rhamnogalacturonan endolyase</fullName>
            <ecNumber evidence="4">4.2.2.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_10787</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endotype eliminative cleavage of L-alpha-rhamnopyranosyl-(1-&gt;4)-alpha-D-galactopyranosyluronic acid bonds of rhamnogalacturonan I domains in ramified hairy regions of pectin leaving L-rhamnopyranose at the reducing end and 4-deoxy-4,5-unsaturated D-galactopyranosyluronic acid at the non-reducing end.</text>
            <dbReference type="EC" id="4.2.2.23"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the polysaccharide lyase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.2.23" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QKZ7"/>
    <dbReference type="OrthoDB" id="2130367at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102210">
        <property type="term" value="F:rhamnogalacturonan endolyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10316">
        <property type="entry name" value="RGL4_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10320">
        <property type="entry name" value="RGL4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1120">
        <property type="entry name" value="Carboxypeptidase-like, regulatory domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051850">
        <property type="entry name" value="Polysacch_Lyase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029413">
        <property type="entry name" value="RG-lyase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029411">
        <property type="entry name" value="RG-lyase_III"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32018:SF9">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32018">
        <property type="entry name" value="RHAMNOGALACTURONATE LYASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14683">
        <property type="entry name" value="CBM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14686">
        <property type="entry name" value="fn3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 13" id="KW-0456">Lyase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0964">Secreted</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017536065" description="rhamnogalacturonan endolyase" evidence="10">
        <location>
            <begin position="26"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="12">
        <location>
            <begin position="375"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Rhamnogalacturonan lyase" evidence="11">
        <location>
            <begin position="465"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF14683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF14686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW62485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="683" mass="76941" checksum="9B3A4FF7F60CC4E8" modified="2019-01-16" version="1">MASYMSVRHTTIGIAFFYLLKPALSFLNVTETNQTLTLINDRLSAAVNKSTGAIYALSLDGQDLLGDLNYVTPTPGGATGSGNSGIGPYLDCYCIPSGSYTPGSIDPKYQLIKDVDSTGTPYGGIVMSEKYPPTGQLFEQYWFLREGETGLHTFSRLAYHNTTTPFLRNLQEFRTLFRPNTILWTNLTTNANQFAPLPSQNATAVEITVQDATWYLGNSTNDPYVIQESDYFTKYMFQDTWRDHDAHGLYSDGTTSQDGSTFGAWLVQNTKDTYFGGPLHSDLVVDGIVYNYIVSNHHGDGTPNITDGFDRTFGPQYYYFNKGTRTASMEELREDALQFYSPTWNLEFYDSIAQYVPNYVPSSNRTTWNGHIDLPDGATKPLAVLAQNNVDFQDNVFDTTAYQYWADIDPKTGDVSISMVKAGTYRLTVYAEGIFGQYIKDDVEVIAGEVHTTHARWREEAAGTELWRIGTPDKSSGEYRHGYAPDESHPLHPAQYRQYWPVWDFPTDFPNGVVYTVGKSNEAVDMNYVHWSVFGGYANFLRPIPYYENVNNWTIYFDMEEKQFHQKRLATFTVQLAGAKTAAGNTDVYNASEPFANLPYTVVINGHELEPWMIPYYQSSSCAVRSAVICYNIAHKFTFDPTLFITGKNEIILSLPANATDYESAVLPQTIYVQYDALRLEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLA5</accession>
    <name>A0A3D8QLA5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">non-reducing end alpha-L-arabinofuranosidase</fullName>
            <ecNumber evidence="4">3.2.1.55</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_10829</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal non-reducing alpha-L-arabinofuranoside residues in alpha-L-arabinosides.</text>
            <dbReference type="EC" id="3.2.1.55"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; L-arabinan degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 51 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.55" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLA5"/>
    <dbReference type="OrthoDB" id="406864at2759"/>
    <dbReference type="UniPathway" id="UPA00667"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046556">
        <property type="term" value="F:alpha-L-arabinofuranosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031222">
        <property type="term" value="P:arabinan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046373">
        <property type="term" value="P:L-arabinose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010720">
        <property type="entry name" value="Alpha-L-AF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055235">
        <property type="entry name" value="ASD1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051563">
        <property type="entry name" value="Glycosyl_Hydrolase_51"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31776">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31776:SF0">
        <property type="entry name" value="ALPHA-L-ARABINOFURANOSIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06964">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22848">
        <property type="entry name" value="ASD1_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00813">
        <property type="entry name" value="Alpha-L-AF_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017653300" description="non-reducing end alpha-L-arabinofuranosidase" evidence="8">
        <location>
            <begin position="21"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-L-arabinofuranosidase C-terminal" evidence="9">
        <location>
            <begin position="456"/>
            <end position="642"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW62527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="652" mass="71122" checksum="2CB7E745123094F0" modified="2019-01-16" version="1">MWSTCFVGVFLISLINWTNAISLSVSPTGGNASSPYQYGIMFEDINHSGDGGVYAELIQNRAFQGSTLIPSTLSPWVGIGNASLTLQNTSIPLSSSLPTSVNVAAGNGVLGIRNPGFWGIDVKVQKYQGSFWVMGSYHGTITASLESASTGEVLASTTIQTSSKTGTWSEYHFSLTPAKAATDSNNTFSLAVNGKGIGNAGLNFNLISLFPPTYKNRPNGMRPDLMEVLKGLNPSFLRMPGGNNLEGRYPPYHWYWNETIGPLKDRRGRPGPWGYANTDGLGLIEYLQVFAIHAHNCFTFLNSKKWCDDLEMEPILAVFDGLYLNRTVIPEADLAPYVQDTMNELEFIMGSTDTVYGALRASIGYPKPWNLQYVEIGNEDNLENGLSSYNKYRFAMYYNAIIAKYPNMNIISSTDVLSTPLGNITEDYHIYTNPPALVEEFNYFDQRTSAHKTLVGEYAITTAANSTARLKYPTWIGAVAEAVFLIGIERNSEHMFGASYAPLLENLNSVQWSPDMISFVADPAKTVLSTSYHLTQLFSKTRFTTVLPVNSTAGFGPCYWVAGLNSDSRQYILKAANYASNSSVPFTVNFGAGSDSTATLTLLTATGINAQNVLGGTNQVITNVTTLVKKSGSFSFDMPSYSALVLTSKIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QPY6</accession>
    <name>A0A3D8QPY6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Plasma membrane stress response protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_10388</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW63886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QPY6"/>
    <dbReference type="OrthoDB" id="296386at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032541">
        <property type="term" value="C:cortical endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005254">
        <property type="term" value="F:chloride channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007632">
        <property type="entry name" value="Anoctamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049456">
        <property type="entry name" value="Anoctamin_N_fung"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049452">
        <property type="entry name" value="Anoctamin_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12308:SF73">
        <property type="entry name" value="ANOCTAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04547">
        <property type="entry name" value="Anoctamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20877">
        <property type="entry name" value="Anoctamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="222"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="297"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="581"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin alpha-beta plait" evidence="8">
        <location>
            <begin position="24"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Anoctamin transmembrane" evidence="7">
        <location>
            <begin position="182"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="707"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF20877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW63886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="758" mass="85378" checksum="B14DB94B65276172" modified="2019-01-16" version="1">MASVRSLYEPDEKVAGNALHTNFDVDYVIDYRFATTGKEQAEAQFTKLIEALNNVGLVTEVRAGDNIGLLIFVKIGSDRHLKGEVYRSRVQDWLYGVRTNAPEKDMQQALGSEPVTEAERLRLIYLLITKPTNEGGAGITPRTGEWKGVQSIFALHDHKFNKAWIKHLSTRYLLDAKDLSEIKDRFGEKIGFYFTFLQSYFMFLVFPAAFGFSSWVLLGQYSPIYAIVNCLWCVVFIEYWKKQQTDLSVEWGVRGVSKITQKRPNFKHETIIKDPITGEDIRVYSPMKRLSRQLLQIPFALAASLVLGSLIATCFAIEIFISEVYDGPFKSYLVFLPTVILTTVMPTLSAVLTGFATRLTDLENYETNDAYEAAMVLKIFVLNFITSYIPLFLTAFVYVPFAQIIVPHLDILQLTVKPFAENEKQMTSPKSGFQINPDRLKKQVIYFTVTAQIVGFALEVIMPYMKRKVFRKVKEVQADRAAKNGGGPAPAAVDDHPEEAAFLVRVRNEAELDIYDVTTDFREMVVQFGYLSLFSIVWPLTGLSFLINNWIELRGDALKIALETQRPVPWRADSIGPWVDALGFLAWLGSLTSAALVFLFSGDGLGPDGTPSDIKAWGLLLTMFFSEHIYLAVQLAVRKALSQLDSPGLQKERAERFAVRRFINPCDITPQYNADETRQFLQESMGEEAAEKAVKGGIQAGEKISRSTLEEEARNSTLRGHGTPEERFWNRQQGQAESIAVGLKMIAKAAPTETKKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQ74</accession>
    <name>A0A3D8QQ74_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">p-loop containing nucleoside triphosphate hydrolase-4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_10461</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW63959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQ74"/>
    <dbReference type="OrthoDB" id="265044at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00876">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001856">
        <property type="entry name" value="RAS small monomeric GTPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020849">
        <property type="entry name" value="Small_GTPase_Ras-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24070">
        <property type="entry name" value="RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW63959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="244" mass="27714" checksum="4005F7150AA2FE14" modified="2019-01-16" version="1">MTITICGDGGCGKSSITLRLVRSQWTHEYDPTIEDSYTLSRQIDGQTYHLSLTDTAGQEEYRGMWAASNLRSDAFLLVYDITSSSSLQELEYFNNLIDMEAETREEAWRSDPANRGRGFVKPIKIVAGNKCDLQESRQVSARTGLEWARKRQCGFMETSARNVVNIEETFALIVRRVAEARRVAEMGERGRDRLTIISESHGTRRAPTAPLSPLPVLREKDEAPIKKNGALYRTFRKLSCLRCW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQL5</accession>
    <name>A0A3D8QQL5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_10601</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQL5"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF28">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00217">
        <property type="entry name" value="SUGAR_TRANSPORT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="49"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="1"/>
            <end position="400"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW64099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="400" mass="44030" checksum="5A6913E9FB2A1482" modified="2019-01-16" version="1">MIIGTILLGSSTTLAQLLVGRIVTGVGNGFNSSTIPMYQSELCRPGNRGILLSMQGTITIVGPCIAYWLDFGLSFVAGPVQWRLPISFQAFFATCLVLQMLSLPETPRYLIEKGRNTEAAEILARLIGDATIDSEEVVFQRRQIETSLELEGAGGPFRYSELLRGGKIGNFRRVCLCCAVNLMQQFTGSNMINYYAPTVYANAMGLSRIVSLILGGCTSLTYLVASFIPLWTVERFGRRNLLMFSAAGLCLCFSMAAILLSIGSRPTAYAATAFVFLFQIFLGIGWLPIPWFFPSEMCVFTVVQITPIAIDSIGWRTFIIFAVFCALWCPIVYVSFSETSQLDLEDVDHLFDAGGWNGGVFGAKGGRTVVAGYHRRHPNSEGMEKEVDFEGEHVQVEERV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQN6</accession>
    <name>A0A3D8QQN6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_10607</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQN6"/>
    <dbReference type="OrthoDB" id="8117402at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:001485">
        <property type="entry name" value="Krueppel-related zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000446">
        <property type="entry name" value="Zinc finger protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050527">
        <property type="entry name" value="Snail/Krueppel_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388:SF54">
        <property type="entry name" value="PROTEIN ESCARGOT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24388">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="275"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="13">
        <location>
            <begin position="303"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="44"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="347"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="652"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="424"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="439"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="462"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="527"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="583"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="596"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="612"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="630"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW64105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="704" mass="74795" checksum="6C36977820BC624F" modified="2019-01-16" version="1">MASEQGTVSNSTPLFNATLSDPAAANAIAINQLESDAARLKSLKRGRSELSQTPSNLSSIASAGLGASPPAKSPRVGGKLSPAFSAAPLTGAAAIEDERRKREEARQNEGRAMSENPGHTALASLMAGGGATMSKPQDAPVATTTMSAGMSTAANAITIPSPIPLEEKAERSPASVTSLASLGSTAQTATASSTVVASPVPMAGIVDEPRELRAAPQHQQLQAADDIQSSNRALTYPGNVMGQLNPPRAPPRGASLPMAGQNQQLVPRSPSQKKHKCPYCDTEFTRHHNLKSHLLTHSQEKPYVCQTCAMRFRRLHDLKRHMKLHTGERPHICPKCDRKFARGDALARHSKGNGGCAGRRASMGSFGGDDDFDESNTGEGDERQMEGVMYTNGTPQRNETEMTEEDRRRFSLPSIKAQHVASAHASQDNYPSHMRTPSTYPPAGPRQAPPQGGLYPPGIDHGTSSSSGSASLQSSIGGQAPTANMSSVPLNPGSGSMYAQGGMTESPKPLSPAGMHSHQLGHESINRQRSPSLTTQFQHQHFGRRQSDRPSPPGMSLPSPHGTSHSSKLPPLPGLAPPDNRYTLPSQIPGQQHPANGPSGQQSQQIQIPQNSMHPSQQSPVSGRAPHHQGSGSADSSNNLFAAGERGVWAYVQTLEDRVKHLSDKVAAMEDKEKSQEDMIRRLQEDVMALRNQSQNNVAASGHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQV1</accession>
    <name>A0A3D8QQV1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_10698</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQV1"/>
    <dbReference type="OrthoDB" id="5357075at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW64196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="288" mass="32511" checksum="3AC66AA276C44761" modified="2019-01-16" version="1">MATQDDLAALFYRNLSLHHDPYVPPPQEVVEDVKEPSPEPEPAYVYSITQHYHHSNHLVSQQQPSRPASEPPQTDQLTTEIILSRHGVDASTLIPAQLDLFKSADATQQMRLVELWRICPFPSYTGLKQDTGSWTTTLEQEEAMAKLRYEQQMLEERLSRVQDRTMDTEDTMSDDSTAPLTPIQGGDGRWMSSHHSAEPYMSSGYEMMAAREYEQSARPKDVYSHFGTAVGGSQYNHATDPVYKSGGDWHVQQQQEAMENQYGAYAQNLHTGWAGVAVGHHGEDEEML</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQX5</accession>
    <name>A0A3D8QQX5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hcy-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_10679</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQX5"/>
    <dbReference type="OrthoDB" id="261426at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.330">
        <property type="entry name" value="Homocysteine-binding-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003726">
        <property type="entry name" value="HCY_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036589">
        <property type="entry name" value="HCY_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11103:SF10">
        <property type="entry name" value="HOMOCYSTEINE S-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11103">
        <property type="entry name" value="SLR1189 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02574">
        <property type="entry name" value="S-methyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82282">
        <property type="entry name" value="Homocysteine S-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50970">
        <property type="entry name" value="HCY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Hcy-binding" evidence="4">
        <location>
            <begin position="1"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="231"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00333"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW64177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="339" mass="36960" checksum="54AC54BE433F8005" modified="2019-01-16" version="1">MASRKTPILLLDGGLGTTLADQHGCVFDASTPLWSSSLLLKSPETLLECQSDFAAAGADIILTDTYQASFKGFASEGSTSLEQSKEYMRSAVQIAGQAFEKAGKGNGKVALSLGAYGATMIPGQEYSGKYDEERLSAEGLRKWHQERIQVFSQDANCWDQIHIVAFETLPMLPEVVAVREVMEGVGKPFWIACVFPGEGTELPDSSAIKDIVKAMLGGPGSNRPIGIGMNCTKIGKLDALISEFEIAIKEMVTAGEVTEWPALVLYPDGTNGEVYNTTTQEWEVKDPNGRSDAPWDERIFDIVSKVEQRDLWSSIVVGGCCKTTPNDIGKLRKRIDQHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QR00</accession>
    <name>A0A3D8QR00_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA helicase</fullName>
            <ecNumber evidence="3">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BP5796_10600</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5' splice site duplex to permit an effective competition for the 5' splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5' splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the U5 snRNP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QR00"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17945">
        <property type="entry name" value="DEADc_DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000322">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057479">
        <property type="entry name" value="PRP28/DDX23-like_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25430">
        <property type="entry name" value="DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 21" id="KW-0347">Helicase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="376"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="407"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="621"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="119"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="774"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="16">
        <location>
            <begin position="376"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="27"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="89"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="119"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="17">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="17">
        <location>
            <begin position="776"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="805"/>
            <end position="818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00038719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00058749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RDW64098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="818" mass="89117" checksum="6774AFECABF47BC7" modified="2019-01-16" version="1">MASFTNGHTNGNDIPSAPVDTNEQTSLPPPPPPPDSHAPPPPPDSEAPPPPPDAFAPPPPSDLPPPPPSKFAPRSTPQSNGRGPLSIEEILKKKKEADDAKAKPKFLSKAAREKLALEKRAKEVEEQKRKLESERSEILGDLGYSAPQNSRGQQPLPQQNGRGSSSSVPTGPRSMRNGDVSSGPVAGRNGQKSRGGEAATAKQPTPSGKGFLAGEKRPTNGDDTESALIRTRYMGSETNQSTFSANKKRRRTAEKKFNFDWNAEEDTSPDYNPLYTARAELNFYGRGRLGGFAEDEAGTLKYAKALEARDSEAGGARAREMLEMERRRREDAGGRNSLDKHWSEKKLEHMRERDWRIFKEDFNISTKGGGIPNPMRNWQESGLPKRLLDVVAQVGYDEPSAVQRAAIPIALQARDLIGVAVTGSGKTAAFLLPLLVYISELPPLNEYTKNDGPYAIILAPTRELAQQIEVEAKKFATPLNFTCVSIVGGHSLEEQAYNLRNGAEIVIATPGRLVDCIERRVLVLGQCCYIIMDEADRMIDLGFEESVNKILDALPVGNEKPDDETAEDAQAMSRHLGGKDRYRQTMMYTATMPPAVEKIAKKYLRRPAIVTIGNIGEAVETVEQRVEFVSGEDKRKKRLNEILASGQFQPPIIVFVNIKRNCDAVARDIKHMGFSSVTLHGSKTQEQREAALASVRSGATNVLVATDLAGRGIDVPDVSLVVNFNMATSIESYTHRIGRTGRAGKSGVAITFLGNEDSDTMYDLKTMLSKSSISKVPEELRRHEAAQQKSVRGGGGQKKIEESSGFGGKGGGGWHSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QRF5</accession>
    <name>A0A3D8QRF5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">GTP-binding protein SAS1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_10722</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Protein transport. Probably involved in vesicular traffic.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QRF5"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01867">
        <property type="entry name" value="Rab8_Rab10_Rab13_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000363">
        <property type="entry name" value="Secretion related GTPase srgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050305">
        <property type="entry name" value="Small_GTPase_Rab"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47980">
        <property type="entry name" value="LD44762P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0636">Prenylation</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW64220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="203" mass="22531" checksum="1860D839EC3D7D0B" modified="2019-01-16" version="1">MAGTRNYDFLIKLLLIGDSGVGKSCCLLRFSEDSFTPSFITTIGIDFKIRTIELDGKRVKLQIWDTAGQERFRTITTAYYRGAMGILLVYDVTDERSFNNIRTWFSNVEQHATEGVNKILIGNKCDWEDKRVVSTERGQQLADELGIPFMEVSAKSNINVEKAFYSLAADIKKRIIDTAKIDHSAPTGVDVGGQGNAGGSKCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QTQ1</accession>
    <name>A0A3D8QTQ1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_09861</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QTQ1"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.450.10">
        <property type="entry name" value="Glucose Oxidase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027424">
        <property type="entry name" value="Glucose_Oxidase_domain_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF201">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE OXIDOREDUCTASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00623">
        <property type="entry name" value="GMC_OXRED_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 8" id="KW-0274">FAD</keyword>
    <keyword evidence="3 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017816805" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="9">
        <location>
            <begin position="19"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="10">
        <location>
            <begin position="118"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="11">
        <location>
            <begin position="318"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="551"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="594"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="550"/>
            <end position="551"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS00623"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW65169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="614" mass="65805" checksum="BBB566467EB53E99" modified="2019-01-16" version="1">MLPSFTIAAVALPAIVFAFPTANIARRSATNDATLVADQTFDYVIAGGGLSGLTVASRLSEDPNIKVLVIEGGQNDSENPMVYDVRNYGQAIGTALDYNLTTSPISWRNNDSLAMVAARTLGGSTSINGATWTKGEKGQYDLLSYLTGDATWGWDSLSQEMLLAEHFNPPLDNLTDSGAQYIASAHGFNGSVQVAFPNGMYENFGPLTLNSSLQVWSGLDINADVSSGHVNGATTVPFALQPDVSQNRSSSYTAWIRGEPETRSNLVILLGHRVVKINWATSNPISGNLVASGVQFQASRDAPVMTVKASREVLLAAGSLQSPQLLELSGVGKADVLAAAGIPLVKSASSVGQNLQEQTKTQFYFTPKSLNFGGTGPSGTIAYPNVWQVLGENASAIYEETIAGLPAYAAELEKAGYIVNATAAAEIMTQQVNGLWNSSQAATEIHFSVSIADKNVGGQIWDLIVLSRGSVHVQTNNSWDQPSIKPNYFAHPLDKKLQVMTTRQVREVYNTEPLASFITAETTPGFSVVPKNATYQEWEKWVEDNFTSVWHNIATLSCMKEELGGAVDNRLKVYGIDNVRAIDASVLPVQLSAHLSSSLYGIALKAANMIKQDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QU39</accession>
    <name>A0A3D8QU39_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_10001</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QU39"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843">
        <property type="entry name" value="BTB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47843:SF5">
        <property type="entry name" value="BTB_POZ DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="2">
        <location>
            <begin position="107"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="28"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW65309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="321" mass="35463" checksum="FE0E0429FD63612E" modified="2019-01-16" version="1">MDEASWQLLHEYRHAMASHMIDMASEVSSSTTKPASSSSTPPPSAAEDSAPRKAVPPQVDVHTQAKTFMQAQARDHNQSSMGHVSRLFPPMTPTQALQQSLAMGRFSDLTIVHGETVWTAHKVIVCSQSPVLEARTKDLQGDSRLDLTEYDSFLVTHVLQYLYTGSYTFPLAPPDFSLPLHISIFTISISLQIPGLESLSAKNFRDCLSNHVSDLDTYFNAIASVYERTTRHHPGLRNAVIEAAVCELRKILGEGAVKDRFLEVLSKQGEFLGDLLRAMISAREVETEVQIVCDDCGPSEEVYQRVVVCKGCGALKLLEFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QU43</accession>
    <name>A0A3D8QU43_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NCT transcriptional regulatory complex subunit A</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Negative cofactor 2 AB</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_10058</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">Forms the NCT transcriptional regulatory complex with nctB and mot1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NC2 alpha/DRAP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QU43"/>
    <dbReference type="OrthoDB" id="653904at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017054">
        <property type="term" value="C:negative cofactor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22906">
        <property type="entry name" value="HFD_DRAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000036">
        <property type="entry name" value="CBF/NF-Y family transcription factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF5">
        <property type="entry name" value="DR1-ASSOCIATED COREPRESSOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="8">
        <location>
            <begin position="197"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="150"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="277"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="29"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="61"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="182"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="303"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00061393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00065307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00072430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00075891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW65366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="316" mass="34733" checksum="50EC46A7E47F3659" modified="2019-01-16" version="1">MESNWRPQSPDLSGFLPSPTKNSHSHLHYQSLPPQQSQSPSQYQPQPQVAPSSSYAPRSPVLTSFNNAPDQYQPSSSFTNHKTYENQNTSAGQDLGDFGDRGYMPPIPALPPIHSFGAQQNEAPYYPEQAFVKTEGNNQYQVDAQQYISSPTMASKTARGRPPKTMAAQPSMLGDPSFQPAPDRKNPNPENIEIKTKFPVARIKRIMQADEEVGKVAQVTPVAVNKALELFMIQLVTGAAAIAREKGGKRVTAQHLKQVVESDQQFDFLQEIVGKVGEGQEGAGGETKKRKGDSDSEEEVKPKKGRGRKKKSSDDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QU86</accession>
    <name>A0A3D8QU86_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Large ribosomal subunit protein mL46</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_09940</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrion-specific ribosomal protein mL46 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QU86"/>
    <dbReference type="OrthoDB" id="414075at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04661">
        <property type="entry name" value="NUDIX_MRP_L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000018">
        <property type="entry name" value="39S ribosomal protein L46, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040008">
        <property type="entry name" value="Ribosomal_mL46"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021757">
        <property type="entry name" value="Ribosomal_mL46_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033650">
        <property type="entry name" value="Ribosomal_mL46_NUDIX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124">
        <property type="entry name" value="39S RIBOSOMAL PROTEIN L46, MITOCHONDRIAL PRECURSOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13124:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN ML46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11788">
        <property type="entry name" value="MRP-L46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Large ribosomal subunit protein mL46 N-terminal" evidence="8">
        <location>
            <begin position="78"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF11788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW65248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="352" mass="39388" checksum="06760D48C0273663" modified="2019-01-16" version="1">MTASSRGSKAAASLIRSSRHPRVCSDCIKSISQTASLARSRPYSAAAAALKTDTQTITQPEIKQAPPVSSTSSEYITQAGIILSRPPILTRPQTAFEKAFFFYQKRLNERLALPFTRYFYFKKDTPADIDWKLKAKDRGGVAAKEIGDYQAYGAESWNDELLVGDEKSDPRSIREALLKDSEMRTIEGQKASEVVEGIKVEKPLSRVTEADRARDVKRLDRALDRTLYLAVKREDGKWGFPASSLIGRENLHQAAERVLVQTAGMNMNTWIVGHAPISHFIAHPWFDKDDSSKVKAPGQKTFFMKGRIMAGQADLKGNALGVKDFRWLTKQELAKVFHSNYYAQVKNALQDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUA0</accession>
    <name>A0A3D8QUA0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Pyruvate dehydrogenase E1 component subunit alpha</fullName>
            <ecNumber evidence="5">1.2.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_10115</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>N(6)-[(R)-lipoyl]-L-lysyl-[protein] + pyruvate + H(+) = N(6)-[(R)-S(8)-acetyldihydrolipoyl]-L-lysyl-[protein] + CO2</text>
            <dbReference type="Rhea" id="RHEA:19189"/>
            <dbReference type="Rhea" id="RHEA-COMP:10474"/>
            <dbReference type="Rhea" id="RHEA-COMP:10478"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:83099"/>
            <dbReference type="ChEBI" id="CHEBI:83111"/>
            <dbReference type="EC" id="1.2.4.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.4.1" evidence="5"/>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUA0"/>
    <dbReference type="OrthoDB" id="10256198at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004739">
        <property type="term" value="F:pyruvate dehydrogenase (acetyl-transferring) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006086">
        <property type="term" value="P:pyruvate decarboxylation to acetyl-CoA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02000">
        <property type="entry name" value="TPP_E1_PDC_ADC_BCADC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000013">
        <property type="entry name" value="Pyruvate dehydrogenase E1 component subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001017">
        <property type="entry name" value="DH_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050642">
        <property type="entry name" value="PDH_E1_Alpha_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017597">
        <property type="entry name" value="Pyrv_DH_E1_asu_subgrp-y"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03182">
        <property type="entry name" value="PDH_E1_alph_y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516:SF60">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11516">
        <property type="entry name" value="PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT BACTERIAL AND ORGANELLAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00676">
        <property type="entry name" value="E1_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4 5 7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Dehydrogenase E1 component" evidence="6">
        <location>
            <begin position="84"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW65423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="409" mass="45365" checksum="B4B69989510B1CC5" modified="2019-01-16" version="1">MFSRALRTNRAAPLRSNAFSKAALVKRTVTTDAASAHADKDSVPEDDVKPFQVHLSDESFETYELDPPSYTLDTTKKELKQMYYDMVATRRMEMAADRLYKEKKIRGFCHLSTGQEAVATGIEHALTKEDDVITAYRCHGYALMRGATVKSIIGELLGRREGIAYGKGGSMHMFAKGFYGGNGIVGAQVPVGAGLAFAHKYRGNKNVSVALYGDGASNQGQVFEAFNMAKLWNLPVLFGCENNKYGMGTAANRSSALTDYYKRGQYIPGLKVNGMDVLAVKAAVKHAKDYATAGNGPLVLEYVTYRYGGHSMSDPGTTYRTREEIQRMRSTQDPIAGLKQKLIEWNVVSEEEIKNIDKEARADVDKEVAEAEAMAVPDSTPQILYEDIYVRGSEPQFMRGRTTDENYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QY35</accession>
    <name>A0A3D8QY35_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Heme haloperoxidase family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_09340</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>heme b</name>
            <dbReference type="ChEBI" id="CHEBI:60344"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the chloroperoxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QY35"/>
    <dbReference type="OrthoDB" id="407298at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.489.10">
        <property type="entry name" value="Chloroperoxidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000028">
        <property type="entry name" value="Chloroperoxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036851">
        <property type="entry name" value="Chloroperoxidase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577:SF19">
        <property type="entry name" value="HEME HALOPEROXIDASE FAMILY PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33577">
        <property type="entry name" value="STERIGMATOCYSTIN BIOSYNTHESIS PEROXIDASE STCC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01328">
        <property type="entry name" value="Peroxidase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47571">
        <property type="entry name" value="Cloroperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51405">
        <property type="entry name" value="HEME_HALOPEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0349">Heme</keyword>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017722612" description="Heme haloperoxidase family profile domain-containing protein" evidence="8">
        <location>
            <begin position="23"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="Heme haloperoxidase family profile" evidence="9">
        <location>
            <begin position="27"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW66591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="257" mass="28147" checksum="B77E35C3FDF1D030" modified="2019-01-16" version="1">MRVHTLLSIGFAIPSLALPSLAFSEPKGHEFRAAGPFDSRSPCPGLNALANHGYIHRDGKNLNYEDINQAAQVAYSYEPGFYKSAVAMVFDFNISTTARPRETFNLLDLARHDTIEADGSLTRNDIYFGDDVHFDATVFAPLANDLGLNYYSPANGFITLDTAATATANRLALAKSVNPAFNASNHQHQTEYGTTALYLLTVWDAEKNAAPKPWVKALLAEDRIAYKEGYTKGKSIKTNTQLGNMTQAIRALAGWKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QY62</accession>
    <name>A0A3D8QY62_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integral membrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09367</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QY62"/>
    <dbReference type="OrthoDB" id="5324692at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="117"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW66618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="867" mass="96495" checksum="0BBC1A8DF9C7D97B" modified="2019-01-16" version="1">MDLLKNARNKVQSTVNDVNTAADPTQYPNAANQSHPQVQYGSPAMKQYGCPRVPYGSQLPQQQDGNHHRPVQLHGSPPQSHYRYASAPQVNYGQCQQPPQQYLYQPRQSVFPSGVSIYHQTPLHGSSQQTQSPSREVPQPGKNYQPAPRVHPMHAEYTHKQLPTPVLDTHERFQHLSPPPPLTSRRPYAQQFPQYQQQAYQSPSVTLPDLASLSLSSKCIGKEPRLIDYVQFYVLKPEVLRGSYVKPLDDDEVTLCESCFLSKIAPNPGIASSFRALEKKPTDPSDSGPEISYDQLVCTFRLPSILSLFNKQCIPRNTITPIVEYLLSPDWSPCTGSEWVESTGQTYYSAKGQGIDNFGCCETCFKLYLRFTSFEGYFNPMSDPPNPNALWGCSFGVHPYTEQVVRTELLKRSPDFRYLVSEIRERIEIPPCPGEGNAIAPGGAEDTYFYEAEPGKSGIFCRECYFDCIRGTVFKHTLGNYVQMTHEQKGTVACDLSSSFSKIAMEVAARANDDEIWRSVMSTRTKVPRCVGISGLDEADFENQEQEHGSLDDWYCFKDFANVEICPNCYWTTINLVGAKHLFTPITRPLRPGVIRMCFLTAAADPSADVGDPNNFENTLAWRGQMLRATLNYGYNAGENFTPTLAAASKISKLPPPCGSIFRNFKEPNGRKWLGRVPAISHEDPNDCQVFLCEECHQNIVQGSLLEPELSRDLTAATHHITDGVGCMAASKRAKNELRDACQKGDLAAFAHYRAKRLEVFKRKMSLNAEMNRHANMQRKGMAVLDMENAQMGTQILMNNNAAMNTTITGIGGSVAQASSNNLYQVGYTSGSIGVSGIMGTMTSMQSRALALLEQGKVLQAEWAAIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYJ1</accession>
    <name>A0A3D8QYJ1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Cytochrome P450-16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_09489</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the cytochrome P450 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYJ1"/>
    <dbReference type="OrthoDB" id="3366823at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016705">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008395">
        <property type="term" value="F:steroid hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11040">
        <property type="entry name" value="CYP7_CYP8-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.630.10">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050529">
        <property type="entry name" value="CYP450_sterol_14alpha_dmase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001128">
        <property type="entry name" value="Cyt_P450"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017972">
        <property type="entry name" value="Cyt_P450_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002403">
        <property type="entry name" value="Cyt_P450_E_grp-IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036396">
        <property type="entry name" value="Cyt_P450_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304:SF2">
        <property type="entry name" value="24-HYDROXYCHOLESTEROL 7-ALPHA-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24304">
        <property type="entry name" value="CYTOCHROME P450 FAMILY 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00067">
        <property type="entry name" value="p450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00465">
        <property type="entry name" value="EP450IV"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48264">
        <property type="entry name" value="Cytochrome P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00086">
        <property type="entry name" value="CYTOCHROME_P450"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6 7" id="KW-0349">Heme</keyword>
    <keyword evidence="5 6 7" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="binding site" description="axial binding residue" evidence="6">
        <location>
            <position position="526"/>
        </location>
        <ligand>
            <name>heme</name>
            <dbReference type="ChEBI" id="CHEBI:30413"/>
        </ligand>
        <ligandPart>
            <name>Fe</name>
            <dbReference type="ChEBI" id="CHEBI:18248"/>
        </ligandPart>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR602403-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW66740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="587" mass="66334" checksum="9E7655F8D4B23947" modified="2019-01-16" version="1">MNSTVGQHVSPLSLPLAQHTVIFWILSVTLPLVVISYWSGYRRIAAGEPPLVPYLLPWLGHGMAFMNDINGFTEWVRSQHPDSPAATVQVAGQHLYLVFDTKLASQIYRRSKNFIFDPFNLMTWGIIGANRSDLEILEMGAQVEKRTPGFQDDGRRVLYDLHRMSGPALTGESLNRLTSLFIDTICKEIDTTFPENDDASYEWVRMDLGEFVKKTWTRASIVALFGSHIFTIWPRIEDWLWEFDEHFQSLLTKMPRFMLPKAWALRDEAWEFLEKWEDEALAAEKRGEIKETDDWDPYWGLQWVAVRAKYLIKQGISAKARAGNESVFLWGLNANTIPIAMQVMNQAVLSPTLLSTLQAEISSAQTGPNTFNMAAVTTAPKLKSVLLESLRWATASPSPRVVREDCQLGEYKLLKGSMVIVHSRTLQMDARTWAIDGVPGSAPEEFWAERFLDGDEREEENRIEENREAETEYAAETFAQTQAQAQARSETAKPHKIVEPISGPKSKEMQQRMLSMRPFGGGTTLCPGRHFATNEILGGLAALLLRLDVKIDEEALEKNGAPVPNLGKQGGLFPDRGLGVWIRRRRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYZ9</accession>
    <name>A0A3D8QYZ9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S8/S53 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_09781</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW67032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYZ9"/>
    <dbReference type="OrthoDB" id="5386278at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07491">
        <property type="entry name" value="Peptidases_S8_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051048">
        <property type="entry name" value="Peptidase_S8/S53_subtilisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43399:SF4">
        <property type="entry name" value="CELL WALL-ASSOCIATED PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43399">
        <property type="entry name" value="SUBTILISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0720">Serine protease</keyword>
    <feature type="repeat" description="ANK" evidence="5">
        <location>
            <begin position="225"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S8/S53" evidence="8">
        <location>
            <begin position="704"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="282"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="60"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="362"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="710"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="750"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="6">
        <location>
            <position position="912"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW67032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1016" mass="113443" checksum="7C68431C786BC04F" modified="2019-01-16" version="1">MAPQPPSMADLMPHMIGPQRSSEANRHLLRRPTGDKDRNPESEDEDEEVEDDDDDDDENGQSSPEDPTKSAFSQILARVKAKELKLGKSDDRKAFFSDYGSYLEGHIDDNKNLLHVLAYEASFNSSVKSLIGRLAKRSPSIFPVLVGALDDNDRTPLYVAITKKNIKLVSCLCENLPSIDDVLRKECDRSETCLHAAIRLKLPAEIIISLVSKASENTLCKKDSKGRTPLHLAVEYEKCSSSQLGVVQALIKQGDSALDEETNGPDYFSVFRYHEYTRDKFLKQKDRKAPSRPNEMSNLRPATGAADQKREAQPESKKPKEENKTKDGPVDKNQPVANSKEPRLQMTPGLSLRNDTVLGAIDPERRGDTDARKNQTEELVTKESADLIRDEIKLHYLRTRRPEIATTRLYGKNLEDTTICFEYAGAPTKVDSDDFKESFRNVKFDTILQYVAFPNVEVHPKPALSKSGGDAIEVSGRGRTDMIFFFEWLRNEKGVKRILKVIVDDIQDPAHSDEAIETALEGFDVEVLEWRKVDLCPETICNSSDKLREVYLSWSGNNAMLRAWSEPDGLKKLENLTKVHLHVKQDLETSIRTTRNINNFCERLRTPVPIEYCGTSTVAPSVASEVSEATARKIEVSRIERGRTEQLVAGNPASLPEKPELTLSPHRWLDCMDGFADAIQNIWRAAVKGKTSQSGDINELHRPVEVALIDDGVDVYHEPLRGKISSGKSFDYGDRGENRMRPYWVSERGHGTVMANMICRVCPMVNVYAIRLETQYDGKDPKPRIVARSAAEAIDAAVDRQVQIISMSWTIKQPEKQRDKEKFDAAMRRAVAAGILIFCSAGDAGAHQDSDYPASCSPNKVIRIGAAKANGNAWEWVGSLNNLDFITPGHEVVQRKSEDVLMQHFQPQTGSSVATALAVGLAALIISCVKLGALHTQSVGVSPTAVTMKDLVEVRQHKNMKAAFDAVGTSRESNNKFIEVWRLFEKAAKDIQPPLEKEKRLGIVADLARNFVRTSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QZ18</accession>
    <name>A0A3D8QZ18_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rieske domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_09766</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW67017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QZ18"/>
    <dbReference type="OrthoDB" id="426882at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03469">
        <property type="entry name" value="Rieske_RO_Alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.380.10">
        <property type="entry name" value="Naphthalene 1,2-dioxygenase Alpha Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.102.10.10">
        <property type="entry name" value="Rieske [2Fe-2S] iron-sulphur domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017941">
        <property type="entry name" value="Rieske_2Fe-2S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036922">
        <property type="entry name" value="Rieske_2Fe-2S_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001663">
        <property type="entry name" value="Rng_hydr_dOase-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756">
        <property type="entry name" value="CHOLINE MONOOXYGENASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43756:SF6">
        <property type="entry name" value="CLUSTER-BINDING PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G03920)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00355">
        <property type="entry name" value="Rieske"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00090">
        <property type="entry name" value="RNGDIOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50022">
        <property type="entry name" value="ISP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51296">
        <property type="entry name" value="RIESKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Rieske" evidence="7">
        <location>
            <begin position="88"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW67017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="408" mass="46595" checksum="C2DEF106D2B5A369" modified="2019-01-16" version="1">MDTMNLSAPVIAIAVVLISAYIYPALVHYNVYHRITTWYAKRNEQFYVREFAESDESILKKVTQFSLKWWTENDIFQLERRAIFSKTWHFVAHASRFRKPGDYRTYEIAGFSFILILGKDQKVRAFHNICRHRAYTITKKESGSSTVLGCRYHGWSYNTKGELVKAPEFDKVEGFQKEMNSLWEIRSVVKESMVFVNLDAGPEVSDLELAAQLKARNTAGVGWISSWKFDAVLNWKLAAGEFSLGRLQNSQNNWQWMLGGSAKTKEMKLSYSASIWTPHGLLLTVRLLPQSPSATTIECDLHAKITHSAKFSSLQKQLKEEIQSEIGRLEIKQRDLSRGHDDFAVAPQEQISRLLRAHLESERQVGHEIEPAARKQGFSVEGKADDDLCAELESNLGCKANKNGLLDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QZ21</accession>
    <name>A0A3D8QZ21_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09822</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW67073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QZ21"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd03443">
        <property type="entry name" value="PaaI_thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF6">
        <property type="entry name" value="THIOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="1">
        <location>
            <begin position="90"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW67073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="190" mass="21255" checksum="5385E09EEF84BE25" modified="2019-01-16" version="1">MADPEEAHFNSIPWCSKLVNDSNFIITGTRSRQPKSGTEDILIFKTLNSNETIKSFLSLYKRPPPGEFWIEEVRVLVTLGTEMNGGPYMLHGGIAATLMDEVLSVLMTINNETHHAEEHPSSTSAVTARLDVRYLRPVSTPGTYLVVARCRERVGKKFILEVEIRDGDGAVLVKADSVWIRVPRIYGNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R2K0</accession>
    <name>A0A3D8R2K0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_08914</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R2K0"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058525">
        <property type="entry name" value="DUF8212"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010730">
        <property type="entry name" value="HET"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10622:SF10">
        <property type="entry name" value="HET DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26640">
        <property type="entry name" value="DUF8212"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06985">
        <property type="entry name" value="HET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Heterokaryon incompatibility" evidence="1">
        <location>
            <begin position="20"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="DUF8212" evidence="2">
        <location>
            <begin position="226"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW68257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="586" mass="66186" checksum="6A3D114B65BA8072" modified="2019-01-16" version="1">MRILDTETLHVRYKQAGERYAILSHVWGEEEVTFQDIQNLDNAQRMAGFPKLAGAASLAKSHGYDCIWIDTCCIDKTSSAELSEAINSMYEWYKKTDVCYAYLEDLNVGHSVQGSVMSVNIETSLRLSRWFRRGWTLQELIAPPNVEFYAKDWTYIGTRDALKGLISTITGIDIYMLEQGDPHKVSIARRMAWASGRQTTRKEDAAYCLMGLFGVNMPLLYGEGDKAFLRLQEEIMKVSGDQSLFVWSRSTQKAGYLYNRYNSFLAMSPDEFRFTGKSVPLLSDQSLGPTASIMTNRGIQIKLAVVPVTARKWGTLPDEPTHLGILAPPYGPSPGTFAAVRLLQLGDSSTFRRVGRDIDTVRTLCPPTPYIPENEIQKSFTISWLYNPQRDIIDSQTLPFGAKADWVKAENLREVTIVSNDHTDIQQMPPISVILGDEFEVLSAWPVGSWDPGTSTMFWPSHSSWDLWRSFECAFLIQCGSRNNSQHKSIGLCLELGRSVECMPPSGEIECISMKYFMVKETYNHENYIQEDNPKETERLLGLLRALENDTTIGYTIEHFLHSPPFELSLHGFGVPGQVRLILNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R2Q0</accession>
    <name>A0A3D8R2Q0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative malate l-lactate protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_08954</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LDH2/MDH2 oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R2Q0"/>
    <dbReference type="OrthoDB" id="7881616at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1530.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.60">
        <property type="entry name" value="Hypothetical oxidoreductase yiak, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043144">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_ah"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043143">
        <property type="entry name" value="Mal/L-sulf/L-lact_DH-like_NADP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036111">
        <property type="entry name" value="Mal/L-sulfo/L-lacto_DH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003767">
        <property type="entry name" value="Malate/L-lactate_DH-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091:SF0">
        <property type="entry name" value="MALATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11091">
        <property type="entry name" value="OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02615">
        <property type="entry name" value="Ldh_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89733">
        <property type="entry name" value="L-sulfolactate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW68297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="362" mass="38807" checksum="375CA40585D8F67B" modified="2019-01-16" version="1">MAETTSDAPKQHVPSHAAQAFVQDLLAHHGVKPENATIIAKCLVSADLRGVDTHGINRLPSYLARVRAGVLDAQAEPTLKQLTPVVAQVDGHNGFGFLAAHMGMSCAVAMAREFGIGMVSVKHSNHFGMSAWVVQQALDEGGMMSLVFTNSSPALPVWGGKEKLMGVSPIACGAPGGDGQMPFILDMAPSVAARGKIYKALRRGEKIPVDWALDQNGNRTEDPEQALRGVMLPMGGPKGSALSIMMDVFSGVLSGSEFAGGVTNPYDPSKPADVGHFLIAIKPDLFMDLKEFKNRMQYLHDKVVGCERMAGVDRIYFPGELEQLCQVEREKTGIPYVEAEIQALNKEADLVGSQQIQTVSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R321</accession>
    <name>A0A3D8R321_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">6-hydroxy-D-nicotine oxidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_09102</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the oxygen-dependent FAD-linked oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R321"/>
    <dbReference type="OrthoDB" id="415825at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.465.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.462.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012951">
        <property type="entry name" value="BBE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016166">
        <property type="entry name" value="FAD-bd_PCMH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036318">
        <property type="entry name" value="FAD-bd_PCMH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016169">
        <property type="entry name" value="FAD-bd_PCMH_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050416">
        <property type="entry name" value="FAD-linked_Oxidoreductase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006094">
        <property type="entry name" value="Oxid_FAD_bind_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973">
        <property type="entry name" value="BINDING OXIDOREDUCTASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G17690)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42973:SF54">
        <property type="entry name" value="FAD-BINDING PCMH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08031">
        <property type="entry name" value="BBE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01565">
        <property type="entry name" value="FAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56176">
        <property type="entry name" value="FAD-binding/transporter-associated domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51387">
        <property type="entry name" value="FAD_PCMH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017730241" evidence="5">
        <location>
            <begin position="20"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding PCMH-type" evidence="6">
        <location>
            <begin position="81"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW68445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="546" mass="60046" checksum="C9359D903F0A168C" modified="2019-01-16" version="1">MRFIVPLAFWAATVSATAGFEGRRYDFAVPNTPVTTFNDNFTSTTEAIASLKAALSANASIAAPLSLQYGSTIARVWPKQLETWPEAIVYPSTPEDVSIIMQFYSKYHGLWEEAFAIMCGGHFSSGGAQTKSLIIDLQFLNAVTLNDPVDASERAIVKIGGGTKSGHVYDELDGTGWAFLGARSTTIGTGGFTLGGGIAYQTGRYGIGADNLVGVEMVLLNGTIIYANPYNNYSDIFWACTGGGWAATIGVVTNFYSQAYSDPGEVQVGAFVYSESKKDSVFPLVNNFFENNTDINAFPAFVYYFKDPDYPSAVAPITEREFVLQFNAMYFGSIEGFNTSYAAFYENANSVSVTSYSLKNLKEFLSSNYPYGQSTIFRGKSHTNVSNDLWENTLSIYKETIQGLLARGEDPANSLWVSEYMYPNWNGAGASNDSATAWPHSTSAHITLSSIMWSNQSNADYVDERDEVMMDYLREYQAGLDSPPIYDYPNYLAPYSKPSEVWGTDNFNRLVEIKEKYDPECLISRGVVIPTTACQSKGLVNYSLDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R357</accession>
    <name>A0A3D8R357_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Inosine-uridine preferring nucleoside hydrolase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_09139</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IUNH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R357"/>
    <dbReference type="OrthoDB" id="432381at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008477">
        <property type="term" value="F:purine nucleosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006152">
        <property type="term" value="P:purine nucleoside catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.245.10">
        <property type="entry name" value="Ribonucleoside hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001910">
        <property type="entry name" value="Inosine/uridine_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023186">
        <property type="entry name" value="IUNH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036452">
        <property type="entry name" value="Ribo_hydro-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304">
        <property type="entry name" value="INOSINE-URIDINE PREFERRING NUCLEOSIDE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12304:SF25">
        <property type="entry name" value="INOSINE_URIDINE-PREFERRING NUCLEOSIDE HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01156">
        <property type="entry name" value="IU_nuc_hydro"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53590">
        <property type="entry name" value="Nucleoside hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inosine/uridine-preferring nucleoside hydrolase" evidence="4">
        <location>
            <begin position="2"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW68482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="347" mass="38123" checksum="67E893F904BD4323" modified="2019-01-16" version="1">MVIMDNDWGSITFIPFLLALKADWKVLGLTSCTCNSWEHQQSLHALATLALGNLTSCVPIIQGATFPLLNTYQRFQAWEMVHGALPYEGVFRPYNATREALGSDPTAGDDPWRIIPEAFIEGFPSAALINALHSNPANAASFMVEQVRKYPGQVSIYVAGAMTNVALAVRMDPQFASLAKELVIMGGYLDINLFQVRGSLQQADDNSDINLMIDPEAAKITLTAAWPSIKIAGNVANQVINSQAFVDEVYQVKNPYSTVFYNNYGTYFPFWDETAAALMVDPSIILNSTTLYVDVDTSYGSPSYGNLHAYQKALMPTGVRNVTYIHQIDGERLHGMIKAAVQYPASC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R399</accession>
    <name>A0A3D8R399_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Dienelactone hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09182</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R399"/>
    <dbReference type="OrthoDB" id="17560at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002925">
        <property type="entry name" value="Dienelactn_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630">
        <property type="entry name" value="DIENELACTONE HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17630:SF105">
        <property type="entry name" value="DIENELACTONE HYDROLASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_4G08790)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01738">
        <property type="entry name" value="DLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dienelactone hydrolase" evidence="1">
        <location>
            <begin position="31"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW68525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="270" mass="29242" checksum="371C01EE67019DBC" modified="2019-01-16" version="1">MSTGVGMSLCCLSGAIHEGTPVGKVEKCGGLDTYISAPADGSKAKTVIFLVDIFGWEFKNTRLLADNYAKAGFYVYVPDVLQGDSLPIEFLQSIEPPLKEQATLSMVDKAKNTAVVGTTLPPWLLRHREATAKPLIDDFIAAVRAIPGTGKIGTIGFCWGGRYSILCAHGKVDAAYACHPSLVAVPADFEGVSKPLSLAMGDKDSLLDQKTVGQIQDAMAQKTEVPHELRIYEDQVHGFALRGDWSSEKDKKAMDEAESQGVEWFQKYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R3C7</accession>
    <name>A0A3D8R3C7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HRQ family protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09209</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R3C7"/>
    <dbReference type="OrthoDB" id="5043642at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021848">
        <property type="entry name" value="HODM_asu-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11927">
        <property type="entry name" value="HODM_asu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW68552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="363" mass="42071" checksum="CE15D540E1BC5BBD" modified="2019-01-16" version="1">MEGKTELAAWAFLILMGLWRLWNWGIEWRKRNPKPVIQEQEEKKTDLETPEIEPLSTFNWRNTEPEKLRPFRPKYHLTMALQNSDPSDLVAMDNTYLQRLETRKEAMSQHPDIVLQATPRSIPAINELYTYLVGTYLPTRYPTMFSLAPTHLENLVTSTRIPLHPSSDPLETLRTLGENIDEDFIWLQPSEDGDGYLFTGYIVCFPAGFNTKDKLGLKLREIHTPVPGYAEKLEKSMDRFFERLEVGKMVRRSNWSITTHDKLYAASAGNHLYAGEEVEAEEIDLANTYLRCERQYLHRQPETKALCFSFKTYLYPISQIKAEGLGEDLARAIDGLKEGSVPEMHFYKKGVVWGETVKEYLRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7D3</accession>
    <name>A0A3D8R7D3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">S-adenosyl-L-methionine-dependent methyltransferase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08362</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW69965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7D3"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF14">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="373"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="390"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW69965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="435" mass="49079" checksum="FCEA330FAC2BCA53" modified="2019-01-16" version="1">MVGFSKTTPILEEQVEGLATQASQREHTPPRSSRQSLQSISTALTSKESYIDADSTSATDDDAFYSDRGTTTSVTSNVWKFDKENGRTYHGYRSGVYYYPNDPKESERLDFQYNVIQEALSNKLHFAPINNPRTVLDIGTGTGIWAIEMGDAYPDALIEATDLSPIQPEVVPDNVQFIIDDASEEDWAVPENHYDFIHTRIMMGSFEDFGQIIRRGFKYTKPGGWMESQDVMHPPFCDDGTMPADWPFRQWSKDIEDAARDAGRPLRTADKLKKWFIEAGFVDVHERAVKLPINTWPRDKSVKILGHWWAENLLSGLQGFSLALLSRVYNWSKDEIEVYLVNVRKAIVDRKVHAYHKFYTVWGRKPLPHEVVTPKAGAPGALATTSSGKEPPRPVPDPDFKCAEPFVPDPQLSDAPTDLPPLPPPSTAEEEFVRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7F8</accession>
    <name>A0A3D8R7F8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GrpB family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_08354</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW69957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7F8"/>
    <dbReference type="OrthoDB" id="630895at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007344">
        <property type="entry name" value="GrpB/CoaE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34822">
        <property type="entry name" value="GRPB DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G01530)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34822:SF1">
        <property type="entry name" value="GRPB FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04229">
        <property type="entry name" value="GrpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW69957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="19953" checksum="FA8E8780284996D2" modified="2019-01-16" version="1">MGVHIEPHNPDWFIEVARVKAHLQAILRDAPFMSIEHVGSTAIPGLVAKPVLDIGIVGRPEDLPALRKAMVEGGYTDQGDCGIPSRIAFQPPPVPGLTMQRNTYVVADGCLSLRNHLDVRRVLLMDQSLRDEYAQVKKALVTSGVADVDEYCRGKTEILLKILRQAGWTQDDLEQVHKANA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R816</accession>
    <name>A0A3D8R816_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_08582</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SCC4/mau-2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R816"/>
    <dbReference type="OrthoDB" id="5565328at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007064">
        <property type="term" value="P:mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019440">
        <property type="entry name" value="MAU2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21394">
        <property type="entry name" value="MAU2 CHROMATID COHESION FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10345">
        <property type="entry name" value="Cohesin_load"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="139"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="45"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="90"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="141"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="169"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="220"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="297"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW70185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="929" mass="103096" checksum="65B71814AE888229" modified="2019-01-16" version="1">MSYQGGNHGYWPGPGQSVPYNSQNPHPQALPHGVPAGAYYPTGQAPMNQPQVAQQWSQNTQHYHQPYGQPNGYAVNQSYSPMSLQRHPQTHPQSQPQYTSPQPALQQIYPQQHTMPHINTPIPHSYTQAQSNYGSHAMYQGQRQPSAGIQRPASSSPSNNISQLPPQPAVKQKAPKPAQARQNTKPPTNSTNPPTNNTSRAPQPTIIRHSELMSPPQAPERTTISPSDLSRPPQTITSINPAELLSNSPGTENTINPAGLLSRTPDRTTTISPANLMSVPTERTISPSNMLRPPSTTPAHRSPSQGDPSMLILSLAEEYFDAAHAMATSVALLADEKSFEQYHKLIATGLGCLETAMKRLKLSPRDEANVILRFAGILYQEDTDNFMDAELALTKGIAISERNHYFDLKYAMQFLLAQFMFKKSPKAAMKALDGNIADAQTYRHYSWVYAFRFLRASRAMELGNLADSQSGLQNLRAISSVSSEQGDRAIFLMSSLMEAMAYLHSANSDAIEQVQRAIAAAWTYQLDEDNQIPQLTGLTHILDVACSLRHGNVKQMLVKLKAMQVMMDEAKKNTTWSYTSDVLAIPISRKQTDSHVVSKDTRAVLGIGKDGRDNLMVTFLNMRDAQFIRQHPADRHGLNVLTETLKSLSVATYQPGKGGNLPDLLHKARWRTELLCYFHIYTAFCDASVTDWRSVKKCIDDLKATISTIEAHSDDPLAYFAKYIEGVFHQGSGHLEEALTIFQSPMFDLSRPPKAHPSTSDQTKRDVSILAALNSVWIQQGPGRQDRRRNTDLLERLGPLCQKHRNRDIRTAYNLLVVTVETEPPQTLIRTKEFLQQALGGAKSTGNELLLCITLNLTCYRFFNNVVGDQAIKSALVAENMADKSGNVLWMSVANGMLAQKYSLQGKHAEAQVKMEEAMRMNQAAFPEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8F5</accession>
    <name>A0A3D8R8F5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8F5"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW70333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="95" mass="9621" checksum="19FEAE44010A7B3F" modified="2019-01-16" version="1">MQVEHVRISAAIAIAIAAAVAVVVTVVVTVAAAIEASSAMAVSAAAGRRVSSSAEATRSSLPAQSHLLAPVRQVLFSSQDPEPNLEGDVSWSKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R946</accession>
    <name>A0A3D8R946_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ankyrin repeat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_08781</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="539213at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051165">
        <property type="entry name" value="Multifunctional_ANK_Repeat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24123:SF33">
        <property type="entry name" value="PROTEIN HOS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="542"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="575"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="678"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="1447"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="603"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="610"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="622"/>
            <end position="631"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW70384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1736" mass="194833" checksum="AB281CA2A804B817" modified="2019-01-16" version="1">MSSVTSKMELPKLPSPSGSVKDFIPFLSGQRDTPIAQIIEPYKAFESELRKIYAQQPDNEAVKDGHINMVPIFGGQEELKIRARSLDTETEAEKSRYIMELKDKDRKPNGSPAVVSSIKDFQKNFNLFSESSLADLDWSNIVAAGSSVTTALLPVPEKWAGNKRSLREYYHEHLAPASDVDLFIYGLDEHQALEKIKLIERNIKDSILHETTTIRTKHAITIASQHPTRHVQVVLRLYDSISQIITGFDVDCACVAYDGKQVFAAPRAIAAFVTQCNTIDLTRRSPSYENRLSKYSHRGFEVHWPLLDRSRVDPTIFERSFGRTQGLARLLILEKLPKAADRDAYMFQRRAERGRPALHRNCRNQYKVGGNIKDQEEDDVAEWVNEAEVASYHTMTIPYGPKYHAARINRLLYAKDLLLNAQWNQPDDREVYLHRHPCFFGTAEEVLQDCCGFCPQPVTDQEIEIAEEESKTMISGELKFLVDDPGRQEIGSFNPITDDEWTTMAYVGDTARLCQAIVDCDLEHVEDWCSQAGVDVNQRDYTGRTPLHLATMASSIEIVACLINHGARLIARLVDGRTALHIAAARGNISMVRLLMLKSNANEAEEEERAADRRDARAESMSEASEISLGSDTEDDSVTMGSFIKVDKNAQESTDDGILEDSSNDPDIYDIDVTAWDYGLSPLHLAILNGHENIIKELVSEYGADVLLPVKLFTPGTRNARGAILSILLALFLPVEKSKRVLKLLLELGATSTQADTNLITGLHYLVSKNRTDLLDVLLTHDRPAALSVVNNVSMVSGWGNSTTTPLVTAIERGDEGMAQKLLEIGAQPTISFDDWIKSYASKHERMKRQTVENNLNEYHNSVTQPILVAAYKDMGNMIEKLMVHGADPATLGKGSHSLIQQHRQHLKYYNHQSGESLLDIVQTKLKLLREYREPQNIPRIGVIYERTSYTDDFIEGSYSHWSATADFHQAKQNIDNQWAEHLKAEQAKTEYGVAEKQQAISDKILELEHAEKSLVEAGARTFADMYPDVPKSERNKLQHWAPAEPTPYETKFTFQIPNLNKIVKDGYLRLFEAVWDDDFETIKKLTLAPWASAGQLSEASLNPPLQIAVKDGNGFSPFSLAVLRGHFDLARKVIEICMAQYHKDDGKTNRQRWNVRTADSDDEISNSDDEDDLPISSELVNNEFTVDSLGQISNIVKSDVLPLTMIEWSCRSLRFDSLSHSQNNLYTLLEHAVMVDDLKLLRFLIEIGTEQQRLAAGENDDLKCYTINKNVFSSAIRLGRTAMLSEMIRATGVGIPLNALSEKSGVEIKSIPKYYEGLSVAGKKRADWAQAPGSNARVVEERITPLLQAAHVGSLDSVEFFMSATPARKYQEFAQENKHDKRIKALEQSGTGFEKTLKTWLSEKSELVLHCAILHNPDKESTPSYLELIKHLVSSVPEYLEKKSSEGWTPLHVAVLQQRHDVASYLISCGADQRSRDRMNRNLIHHSVCPRRGRYQIQSETDKLESMIEILDAENVKEMMLERCAHTPGALTPLAYWMAKRYDAHYTKSNIIAVLCKHSDLQELEMINGAGDLPLHVAIKEGLSTITSFFLSLKPTLLYRENATGRTPLEMSHEIYIASCVENPLAMPARANYYPGSSNQSLIVSKPAEAFVRTGEVQSPEESKKRTWKICEGIDEQVRGGEGSKRRLVSLFEANEIAKRVAGRNNNGGRGSHIIVNGGIVDGDVKMDVVSEWMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R960</accession>
    <name>A0A3D8R960_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Carrier domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08835</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R960"/>
    <dbReference type="OrthoDB" id="10253869at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031957">
        <property type="term" value="F:very long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001031">
        <property type="entry name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24096:SF267">
        <property type="entry name" value="MALONATE--COA LIGASE ACSF3, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00975">
        <property type="entry name" value="Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Carrier" evidence="1">
        <location>
            <begin position="661"/>
            <end position="738"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW70438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1048" mass="116084" checksum="08E80A2B63F7126F" modified="2019-01-16" version="1">MPPQNLFQLLQQAIADGPDCGLTVYGAIREAQPTIKLTYKQLLDAAEKRAQCLVRKSHTKSGSVILLHLDNHLDNIIWFWTIVVAGCIPCVSTPFPKDAEHRHKHIYHLQRLLRNPLIVTSANLMPEFSGTHNTDVFIIENAFDAVPSMASGPSNLSHAMAAVHLSQGHDSAARVLGDEFVTNYSLDGSAHSNGVSNAARHIARNVGSTSSTNYDPESTGTHSPVYTGFDSALLDTETPSSPRTACEKSPDDLAVLMLTSGSTGDAKAVTLQHGQLLKALASKSAYLETNSSDVFLNWVGLDHVANLTEIHLHSMSLAAEQIHLPKDVVGQPLAFLDAIEKHKVSYTFAPNYFLAAIVRALIEGYPSIHNANQATGDARDLSSLKTLISGGESNVIETCITLTNLLHKYGAPNSFIRPGFGMTETCGGCIYSKDCPRYDLQGNMEFASIGSCIPGISARVFRENETFASVNEIGTLRVQGQFVFQGYYNDEKATHELFTLDAWFNTGDLARRDDAGMLHIVGRKKETLVINGVNYHPEIVEAAIEGAEINGAAPSYTVVFSHRPKGSPTELPCIIYLPTYDTDDNKTRVNTSLELRKVCIACCGVQPYVTLPLEPSLLIKSSLSKLSRNKIRKAFESGLYQKHKEKDEIVLRAYRAAVYEAPSSQTELAIVAILHDLFECGTTDIGVNSNLFDFGVSSVFILTVRQKLKSRLHVDVPIAKFFNHPVVRDLAQAIDKIAKTINDYDPVVTLQTQGTKTPIFFVHPGLGEVLLFVNLARYITDRPVYALRARGFDGEPYFDKIEEMIKTYMKAIKRVQPQGPYSVCGHSFGSILTFEIAKRLEAAGDDVKFVGVFDQPPNFKKLEHECNWCDVAYTLAFFLGLTETWYYYEFMDDVSEDSSQEDVSGGVRNEGNSQKDVLSVVRDEATEREDVLETIFGVAPAERLNELGLNKERFRVWVDLAYNLAIIGREYDPKGMVSNMDVFYADPSAIAQVKDLDEWFNGYISQWKNFAKSIVFHKVEGGHHNLISPPHISSFQKLFKDALRKRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCV3</accession>
    <name>A0A3D8RCV3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein HRI1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_07755</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the HRI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RCV3"/>
    <dbReference type="OrthoDB" id="4045395at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd11693">
        <property type="entry name" value="HRI1_C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11692">
        <property type="entry name" value="HRI1_N_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.320">
        <property type="entry name" value="Protein HRI1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031818">
        <property type="entry name" value="Hri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038744">
        <property type="entry name" value="Hri1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043047">
        <property type="entry name" value="Hri1_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16815">
        <property type="entry name" value="HRI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW71721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="233" mass="26968" checksum="163A055F38AB7174" modified="2019-01-16" version="1">MQTFTRPTFYTRLDRPSDEANVYSTLVLTSAGKHYVDVRVFLTTSPHESQKLEWGFAGTSQSAPPQFDKDNKLVKPGHSKWNHWVDNKTVEEVQDEGYMYPIEGSNEVRETGSMAHPETGKTTPYEEIWIDLEVVKVGEKGKYASWVMKHEDSSSHTRGMLCRIGEWVQGVLRIGDEISVVRYKWDTEHSQWQLKLSMGRFDMPRDVVLETDRELSVGEEFGDWIVVESLYWL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDS9</accession>
    <name>A0A3D8RDS9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MFS general substrate transporter-28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_08233</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDS9"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06179">
        <property type="entry name" value="MFS_TRI12_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010573">
        <property type="entry name" value="MFS_Str1/Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053791">
        <property type="entry name" value="MFS_Tri12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF109">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06609">
        <property type="entry name" value="TRI12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="145"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="284"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="360"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="539"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="56"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW72199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="595" mass="63284" checksum="52B0F50197CF3452" modified="2019-01-16" version="1">MDDHAKDITATEVEHAPSTSPVSAKSIEENDALHGFQAEESSLPKGYYRSSFFIGTMFATGLGLAAGVGGFALAAPNLGVINADIGPDANLAWVALVYTLTLAVGLLLVGRLSDLFGRRWFFICGSILALIGNIVAATAQSIPALIGATTLIGLAASTQLSFSFVSNELVPMKYRFLTNAWLYLWTVPISGLGPAISKAFILRTSSGWRWCYYLMIILNALSGLLYFCFYHPPTFNMKFKNRSKLQQFKDFDFVGCLLFTGGLLLFVMGLSWGGGLYPWKSGHVIGTVVSGALGIVAFFLWEIYVPLKEPVVPMHLFKNIEWVASCLLLSLGASVYYAMATIWPSMVAVLYTDDGGASMYAGWLNCISGTMIVAGQICAGCFAVAIGKTKFQCITVLIIGGALLGAMASCTPDSKDRAIVLMTVGCFAIGWNESVCLANAGIEIEDQQEIGTAVGMAGSIRSAISTVCSSIYTAVLINRLGQTIPAEVPPAIVAAGLPASSVPAFLGALTTGNFSGVQGLTTDITLVGVKAYKQANAHAYSTVFLTSLAFSGLAIVISFWSPNVDERMTGEVATTLHQRDKTLVGDNKLYTESKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RI99</accession>
    <name>A0A3D8RI99_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CUE-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_07217</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RI99"/>
    <dbReference type="OrthoDB" id="5577209at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14364">
        <property type="entry name" value="CUE_ASCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052586">
        <property type="entry name" value="ASCC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041800">
        <property type="entry name" value="ASCC2_CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003892">
        <property type="entry name" value="CUE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21494:SF0">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21494">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 2 ASC-1 COMPLEX SUBUNIT P100"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02845">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00546">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51140">
        <property type="entry name" value="CUE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CUE" evidence="2">
        <location>
            <begin position="468"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="514"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="604"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="716"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="514"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="604"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="740"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="768"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW73775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="798" mass="87694" checksum="8753F66B0DC6558B" modified="2019-01-16" version="1">MKVIVEKFLMAMQKTKREFRRIPLCGSVVGELLAPARTQPDEVTPNDKAAASSARHRILDWTAIHRQGRPKSSPTSALNIWRCANSDNWATIRKSKVVLNPAVGGPTLAQGHHQAPIDNYAFSLQQNQKTSLKMASKLLPPMAPFPEAAWRNHMVPEEWEACLDAWIMLAEAHLSLSDPDFLKISAQDDSLGQFLISYTAESAQPAGYSDSGPKAKELRRESFLLVYRLLGAGPAPEALMSWEFLSDSSKIYSRKHAQKLLESAWKRNAAGLEVSLGHLKTSLIKLLDAGLKGNVQKVEANLKRLNHLLHASPDAAAFFLAGSDFLDGLISCYKVMNPPLRKVIISTTYLCLVGLTEGEKPNFSSLVDQLYSLKSAAEAHKAGPTNVNDSLVAELITVTPILKQVQQRIESSGSGSSRVKSVLAELEGFKKAGAARPPRLIKRMINKGKGIANDEEDGLEMHGQVHIHRMSLITQIQDLFPELGSGFVVRLLDEYNDDVEQVISHLLEESLPEHLQNSDRSEAFQPAQHRDPAPDLAPHPTPPQLPVRHNVYDDDEFDNLAISTSKLHFGRRNPDQTADDVLQDRSTAPNKAAILSALAAFDSDDDERDDTYDVEDVGGTVDSTNPEETVTTASTSSAHDEVLFRTWKATPAAFERDANTRRSKARSTLREATGMTDEALEGWAVMLSRDARRQRRLEAQFESFAGAQRDLKATAWRADQAGSGAEESDADARGTGQPRGRGRGRGRGGRGRGNVAGPTGDKETEVARHRKEANKGSRANHNRRDQRAKKMARGGFPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIZ9</accession>
    <name>A0A3D8RIZ9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative clathrin heavy chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_07378</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <location evidence="2">Coated pit</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the clathrin heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="2113814at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030479">
        <property type="term" value="C:actin cortical patch"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071439">
        <property type="term" value="C:clathrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000001">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000002">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000007">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000009">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.730:FF:000003">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.110:FF:000003">
        <property type="entry name" value="Clathrin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.110">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055358">
        <property type="entry name" value="CHCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016025">
        <property type="entry name" value="Clathrin_H-chain_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022365">
        <property type="entry name" value="Clathrin_H-chain_propeller_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016341">
        <property type="entry name" value="Clathrin_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292:SF1">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00637">
        <property type="entry name" value="Clathrin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13838">
        <property type="entry name" value="Clathrin_H_link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01394">
        <property type="entry name" value="Clathrin_propel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002290">
        <property type="entry name" value="Clathrin_H_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50989">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0168">Coated pit</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="CHCR" evidence="9">
        <location>
            <begin position="541"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="9">
        <location>
            <begin position="693"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="11">
        <location>
            <begin position="1220"/>
            <end position="1249"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="9">
        <location>
            <begin position="1390"/>
            <end position="1535"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="9">
        <location>
            <begin position="1539"/>
            <end position="1680"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="9">
        <location>
            <begin position="1685"/>
            <end position="1831"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="9">
        <location>
            <begin position="1834"/>
            <end position="1977"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="1250"/>
            <end position="1277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW73936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="2085" mass="234891" checksum="B1655B33EC94FCE6" modified="2019-01-16" version="1">MAPLPIKFTELLQLPNVGVEAASIGFNSCTLESDSFICIRETKPGATSPEVVIIDLKNNNNVIRRPIKADSAIMHWTKQVIALKAQSRTLQIFDLGQKAKLKSATMNEDVVFWKWFSETSLGLVTETTVYHWDVFDPSQAAPVEVFKRNPNLQGCQIINYRVSDDGKWMVVVGISQQQGRVVGAMQLYSRDRGISQAIEGHAAAFGTLRLEGAPADTKVFTFAVRTATGAKLHIVEVDHQASNPAFAKKAVDVYFPQEAVNDFPVAMQVSQKYSVIYLVTKYGFIHLYDLESGTCIFMNRISSETIFITAQDSESAGLVGVNRKGQVLSVAVDETTIIPYLLQNPANSGLAVKLASRAGLPGADNLYANQFEQLLSAGNYAEAAKIAANSPRGFLRTPQTIERFKAVPAQPGQLSVILQYFGMLLDKGTLNKHETLELVRPVLAQNRKHLLEKWMKENKLDCSEELGDIVRPHDINLALSIYLRANVPQKVVAAFAETGQFEKILPYATQVGYQPDYVQLLQHIVRINPDKGAEFATQLANTEGGSLVDIERVIDVFQSQGMVQAATAFLLDALKDNKPEQGHLQTRLLEMNLMNAPQVADAILGNDMFSYYDKARIAQLCEQAGLAQRALELYEDPEAIKRVIVNIVATPTFSPDWLTNFFGRLSLEQSLDCLDAMLKVNIRQNLAAVVQIATKYSDLLGPTRLIDLFEKYKTAEGLFHYLGSIVNLSEDPDVNFKYIEAATRMGQFSEVERICRDSNHYNAEKVKNFLKEAKLTEQLPLIIVCDRFNFIHDLVLYLYQNQQFKSIEVYVQRVNPARTPAVVGGLLDVDCDESIIKGLLQTVNPASVPIDELVAEVESRNRLKLLLPFLEATLAAGNQQQAVYNALAKIYIDSNNDPAKFLKENEFYDTALIGAYCASRDPSLAQLKAWFCVTTVPIHSIDSQPKMAADASDILEYMVFLVWNLLSLTPASLKNPVYKVIIDTEVVLESLMTDCGLEFAPGLLDAVQAATPPTVEFFKTLPTVGNNKLWAVYLLVLEKPGCRPKTYIGSGTHGTRGVAGRHKEYDRKINLPRWVVRALNDGFQIVHKGLLCWAPIPTTGKKILFRGMFLAIEATLSIVLWVMVSRTKDYGMPHFCPWPISDLEYDGCCNHTALLEHLHDEAEFLTLEQLAAKEIEMEERRTASILACYQRLVQFKREKFSKWQALLRERREKRKASGRFACDICDRKFDGPSALSDHITSKRHISKATFTTEEIEAQKLETERKQKEQKAAKVLAAYHDFKRLDFDKWKAKQAEKAAKLTLAKRREYQSTTRANIKASGKFACKPCAFIAYSKGQNDLELVNITNENAMFKAQARYLLERADKELWMFVLSANNVHRRSVVDQVISTAVPESTDPDKVSIAVAAFLESDMPVELIELLEKIVLEPSPFSDNQNLQNLLIFTATKADKGRVMDYIHKLDGYNAPDVAQICIDVGLFEEAFEIYKKIDDHASATNVLVEHVVSIDRAQEYAERVELPQVWSRVAKAQLDGLRVSDGIASYIRAEDPSNYSEVIEIATHAGKDDDLIKFLRMARKTLREPAIDTALAFAFARTDQLGELEDFLRGTNVADIEESGDKAYAEGFHQAAKIFYTSISNWAKLATTLVHLEDYQAAVECARKANNIKVWKQVNAACVEKKEFRLAQICGLNLIVDAEELQGLVKQYERNGYFDELIALLEQGLGLERAHMGMFTELGIALSKYHPDRVMEHLKLFWSRINIPKMIRATEEANLWPELVFLYCHYDEWDNAALAMMERAADAWEHHSFKDIVVKVANLEIYYRALNFYLQEQPSLLTDLLQALTPRIDVNRVVRMFEKSDNIPLIKPFLLNVQSQNKKIVNNAINDLLIEEEDYKTLRDSVENYDNYDPVDLAQRLERHDLVFFRQIAANIYRKNKRWEKSIALSKQDKLFKDAIETAAMSGKPDVVEELLRYFVDIGSRECYVGMLYACYDLVPLHVVMEISWRHGLTDFTMPFMINYLAQQSSTIEMLKKDNEERKLREKSQQKEENDTPILGGGRLMITAGPMAGSQAPASFGQTNGFAPQPTGYGGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJ46</accession>
    <name>A0A3D8RJ46_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RNA-3'-phosphate cyclase family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_07507</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJ46"/>
    <dbReference type="OrthoDB" id="1911237at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00875">
        <property type="entry name" value="RNA_Cyclase_Class_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.20:FF:000004">
        <property type="entry name" value="18S rRNA biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016443">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03400">
        <property type="entry name" value="18S_RNA_Rcl1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF1">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="5">
        <location>
            <begin position="12"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase insert" evidence="6">
        <location>
            <begin position="208"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW74065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="406" mass="42635" checksum="C0FB9670725E5E88" modified="2019-01-16" version="1">MSAPAPEFLHFTTHKSLTQRLVLSTLTGRPIHISQIRSSSPTNPGLAPHEVSFLRLLESVTNGSSLQISYTGTKLTYMPGLITGSAAGLGTSGDVIKHNLPATCTRSVSYFLIPLCMLAPFSKAPLNVRFEGEGVITSATQSGDISVDAVRTAILPLYEHFGILSAKLELRVLQRSCVGAGGKGGGGVVELRFGSQVRLPKTLHLNRSPGRVRRIRGVAYCTGVSASNNARMIHTARGVLNPLVSDIHVAAQYDQAPLVSSHDKSDPKARKRTGIGFGLCLIAETASAGVIYSADVAAPPEGGVTPEDLGLQCAYQLLEVISQGGCVTRVGASTVLTLMAMGSEDVGRVRLGRDIVGSEDLVVLGRDLKKFGASSWGLRDVDEDDSGDIIVAVKGSGVGNVGRKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJT7</accession>
    <name>A0A3D8RJT7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_07606</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJT7"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF10">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW74164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="345" mass="38694" checksum="CE87873DDDCB16B5" modified="2019-01-16" version="1">MDRTAQQEHAENAQSVAHQAAHTIEVGEDVDPSDDGYATDDASRASTSVSSSVRDYSFENGRRYHAFREGTYLFPNDESEQEREDMKHAMVVNLCGGALHYAPLENPQKVIDIGTGTGICAVDMGDEYPEATVLGIDLSPIQPSWVPPNVKFMVDDAESRWLHPENHFDFVHVRNLASSIKDFPKLISAAYAHLKPRGWIELQDLYFKVECDDGSMPEDYVLAKWLDNMEHGLKNFGVDLLGPRKHPAYVEEAGFVNVQQKILKVPIGIWPKNKTLKTVGLYNRTMIIDGLQGNSMKVFTKGLGWSVQEVEIFNMEVRKAVMDSSIHSHLTFNVLYGQKPPENTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJT8</accession>
    <name>A0A3D8RJT8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">EGF domain-specific O-linked N-acetylglucosamine transferase</fullName>
            <ecNumber evidence="1">2.4.1.255</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Extracellular O-linked N-acetylglucosamine transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_07553</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-seryl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48904"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:12251"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:90838"/>
            <dbReference type="EC" id="2.4.1.255"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = 3-O-(N-acetyl-beta-D-glucosaminyl)-L-threonyl-[protein] + UDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48908"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:12252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:90840"/>
            <dbReference type="EC" id="2.4.1.255"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.255" evidence="1"/>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJT8"/>
    <dbReference type="OrthoDB" id="529273at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049625">
        <property type="entry name" value="Glyco_transf_61_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007657">
        <property type="entry name" value="Glycosyltransferase_61"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961:SF148">
        <property type="entry name" value="EGF DOMAIN-SPECIFIC O-LINKED N-ACETYLGLUCOSAMINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20961">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04577">
        <property type="entry name" value="Glyco_transf_61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 61 catalytic" evidence="11">
        <location>
            <begin position="326"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00042574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW74111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="521" mass="58951" checksum="10D217592C70FD7E" modified="2019-01-16" version="1">MIAPTRRRWIALCMALGISYWTVNLTKIFKHLDIKIDVKIGSSSILPHTSSDFYPFSNPLSRTTSRYPSYPLEYTPSSLDSAECQASFSPKYLEHTASHHVPYCERQSRSSMECFRTHNDGHFCLATGVLLAPKHTGADQTAAMHCRLRNFTRERLESPRKEVELRNVVDVNSMRSGFFETGVMEQLKHWNISAGEENMMVSREQRSCDFRSSDKKWTLLVKREGRRNLWHMLLEIWQATITLDVLQMAINPNTGRPYLTPNDIANMQVIFAPGDPGIHSAVDELWTMVTGHRPILQEDIDTTCLGNVILPLEGSTSPLWNSVWEPQDCHDRFLINAFLRRIHRHFGIKATQGSLQSPENPVVTVIERKRKRKIRNLEYLVSRAKARWPEATFQLIDLATLSLKEQITLMLSTSVLIGMHGAGLTNLLFLPAGASIAEIQPPNRRMPESPPFAGFRNLAVMKGLQYFTAHPESRLADDGAGHWQDGEWVDVQEGVFLALVDAAVNSQLNRGVGIGEVLPRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RNE4</accession>
    <name>A0A3D8RNE4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Thioredoxin peroxidase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Thioredoxin-dependent peroxiredoxin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_06443</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the peroxiredoxin family. Prx5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RNE4"/>
    <dbReference type="OrthoDB" id="195498at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03013">
        <property type="entry name" value="PRX5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000020">
        <property type="entry name" value="Peroxiredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037944">
        <property type="entry name" value="PRX5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013740">
        <property type="entry name" value="Redoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430">
        <property type="entry name" value="PEROXIREDOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10430:SF16">
        <property type="entry name" value="PEROXIREDOXIN-5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08534">
        <property type="entry name" value="Redoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="4"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate" evidence="8">
        <location>
            <position position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00079296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR637944-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW75622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="166" mass="17705" checksum="16871532D8007996" modified="2019-01-16" version="1">MVELKVGDSFPEGVTFTYVPYTEDKGDITACGIPINYDASKEFAGKKVVLFSVPGAFTPGCSAKHLPGYIENLGQLKGKGVDIVACIAFNDAWVMSAWGKANGIKGDDILFLSDGGAEFSKKLGWTSGERTARYALVIDNGKIVYAEKEPGREVSVSSAESVLARL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RNI9</accession>
    <name>A0A3D8RNI9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mob1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_06440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RNI9"/>
    <dbReference type="OrthoDB" id="8170117at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="53"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="137"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR605301-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW75619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="269" mass="30783" checksum="98C2A3DDB668A33B" modified="2019-01-16" version="1">MASLFQFLSPRPPKVLSPVCTLSQIATPEACSESIGGDDFVQTPEATYISPYSQQGCHSNQRTRNQFRPRNATKGTTSYQLRQYAEATLGGGSLRKIVKLPEGEDENEWLAVNMVDFYNHINLLYGSITEFCSPQSCPEMKATDEFEYLWQDSENYKRPTKMPAPTYIEHLMGWVQSNIDNETVFPSRIGVPFPKSFPSMIRQVFKRMYRVYAHIYCHHYPVVRELGLEAHLNTSFKHYVLFIDEHSLASGKDFWGPLGDLVDSMLRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RNV5</accession>
    <name>A0A3D8RNV5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">SART-1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_06459</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNU66/SART1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RNV5"/>
    <dbReference type="OrthoDB" id="5583at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000481">
        <property type="term" value="P:maturation of 5S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045347">
        <property type="entry name" value="HIND"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005011">
        <property type="entry name" value="SNU66/SART1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152">
        <property type="entry name" value="SQUAMOUS CELL CARCINOMA ANTIGEN RECOGNISED BY CYTOTOXIC T LYMPHOCYTES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152:SF5">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19252">
        <property type="entry name" value="HIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03343">
        <property type="entry name" value="SART-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="18"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="303"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="533"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="620"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="111"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="456"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="533"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="629"/>
            <end position="648"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW75638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="677" mass="76397" checksum="D1335C5604265E5B" modified="2019-01-16" version="1">MADAISIEETNRLRVSLGMKPLPVPGASGPVFKEATSGPPEEVASTLESRQAEGYENYRKLQEAEEAKKRREAKAEAIKKARDAAKKFSKLEGKGLGDDDEDDLDAKSWLIKQKKRQKEIEKARKREQELAEAEAAAEAEYTAKDLAGVKVGHEFDTFADGEEQVLTLKDTTIDENEADGDELENLDLREREKLTEKLELKKKKPVYNPNDAEEGGSILAHYDEDIDGKKRSRFTLDGQGSTTEASLVAEGIVKKPKTTAISLDILSMDGDLCHANLLLTLSPDEVPKSDYYDISEIKIKKPKKKKAKSTRQKTVDEDDLLPLSEPSGPVETTDSMELDQVVEPTKKRTFQDMSFVDDDELQASLAAQRRNALKKRQKLKPEELVQRMREEASATPAAENEIEEDNIGLIIDETSEFVSNLQKPVAPERKPKAVVHPSSAVTAMGAESDEEGDVDMDRSYANIEDEEELRERLKRQESADAEMTNNGLEEEATLDKGLGSTLKLLKERGILKTEDSGDLNAIFINKQKFLAEKQRREADAEKKARMQRERDRTSGRLERMSAREKEEYARQQNNYRDQQESRQLAEHFNKEYKPNVELKYIDDHGRSMNQKEAFKHLSHQFHGKGSGKQKTEKMLKKIEDEKRRESRSALDGSQMGGMSGVTTQQLKKRREAGVRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RNV9</accession>
    <name>A0A3D8RNV9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydrophobin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_06603</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RNV9"/>
    <dbReference type="OrthoDB" id="10340991at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017612521" description="Hydrophobin" evidence="1">
        <location>
            <begin position="19"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW75782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="65" mass="6648" checksum="BD07FF73610F3CBE" modified="2019-01-16" version="1">MQFSIPTIFLALAALALALPVTPSTARDLVAIDPTITTGSVDPTVNVGDLCAGISVCDPITVNHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RQ52</accession>
    <name>A0A3D8RQ52_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_07014</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RQ52"/>
    <dbReference type="OrthoDB" id="10021397at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000484">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF187">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="136"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="195"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="225"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="423"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="465"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="540"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="9">
        <location>
            <begin position="72"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW76193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="587" mass="62909" checksum="81709DB0894C6B09" modified="2019-01-16" version="1">MAGQVDSTPDIPFHGGDGQHPAIESQATSAANNHDTSSETAMTNAPGASMDMSDPIIAAAPPMQRGVKFWAIMAALCITSLLSALDAAVLSTALPTIVKDLNSSDVYVWTINAYFLTMTCFQPLYGQTANIFGRRWLMIGSVVLFGVGSAVCGSAKTTTALIVGRAVQGVGGGGINVMVDIIVSDIIPLRERPKYMAVIFVVFALGTSLGPFIGGALTQHASWSWIFYINLPIVGLSLILLVLFLHVDYKPDKFSAQLKRVDFLGNAILILSVLAILLALTWGGTTHPWSSWRTVVPLVLGFLGLIAFFLYEASPFVQEATMPLHLFSNRTSASVYAITFIHSIIMYWVVYYLPVYFQAVLEASPTASGVDLLPTAVTSIPFAIVSGIAISSLNRYRPSQFASMILVSIGLGLFTLLDERTSTGYWVGTQILCSAGLGILVTASLPAIQAPLEEKDVATSTATWAFLRSFGSIWGAAIPTAIFNTRINALLPKIPSVSVRNALKNGGAYALASKEFMQSLNATPDIKEGVVKTYVTALKLVWQVSIAFGLLGLLLAFIVKEVKMREALDTEYGITEKAKVETNGDKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RQQ7</accession>
    <name>A0A3D8RQQ7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycosyltransferase family 8 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_06962</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RQQ7"/>
    <dbReference type="OrthoDB" id="2014201at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050587">
        <property type="entry name" value="GNT1/Glycosyltrans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11183">
        <property type="entry name" value="GLYCOGENIN SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW76141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="338" mass="38594" checksum="6755CEEFB9682734" modified="2019-01-16" version="1">MASFRAMAASIWQMFRTAAAVATLLLLVCSLRGLKPPSSRLVSFATRLPLPIHKYAYCVFLAPGDQTNGNTIETEDHYFIGTRMLIHSLLHDATTKTTTNIPFIVLVTPDISQETRRRLTKDGAHVVEVSPLKFDWIKPGNKRWEHVMDKLHVFKLTQYEKVLLLDSDHVVVKPLDGIFQDPATDDMPNLGKSENIHDDEGDQPATYIMAGNSGPREAPHPYPSERGRRLNAGFVVLKPSIKMYKHYITVSSIEGRFPGSSPEQDLWNYVHSDKGNMPWKQINPDWTVNTPCYNDYEHGIASFHEKYWKCGRDLPLRDVLLRSRYKMEAFFQAYDQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RV46</accession>
    <name>A0A3D8RV46_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_05698</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW77846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RV46"/>
    <dbReference type="OrthoDB" id="4360026at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW77846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="361" mass="42195" checksum="99E23286BBE4E7FA" modified="2019-01-16" version="1">MSKNIPDMKKEEEIPYCIWHPHTADEPTYRALAKKYPQMRYHVGRPCAVAGYTNLFHELDLLSDISIAEEARDNNKLVIFDSIMSSPFKYAVMNDYTRSINTDNPRVGNLNADTAVRSTLEIKQKYRSTPEPDDPSRPWPDHQWQYYFFKYGYHFNITEDWCVDENETDLCKELPGDAQLLPLLYSPLPLDLPNIDKDLLVLTAAYYGDIDRYARLRRPHIKEPELSCIVRGIYHNTMFAKWWSNQPEAQPEAHEWKHAIRCAITARFIMNNDLSRVTEETPERDLPYLIYYPSLAQPSTYEELVRRKPSMAPQVARASIIMDHQWLYDKLPVKPDQGLMREAKQALIHITLLISKEELTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVE0</accession>
    <name>A0A3D8RVE0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">alpha-1,2-Mannosidase</fullName>
            <ecNumber evidence="9">3.2.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_05817</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 7">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the glycosyl hydrolase 47 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.-" evidence="9"/>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW77965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVE0"/>
    <dbReference type="OrthoDB" id="8118055at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004571">
        <property type="term" value="F:mannosyl-oligosaccharide 1,2-alpha-mannosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001382">
        <property type="entry name" value="Glyco_hydro_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050749">
        <property type="entry name" value="Glycosyl_Hydrolase_47"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036026">
        <property type="entry name" value="Seven-hairpin_glycosidases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742:SF103">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MANNOSIDASE MNL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11742">
        <property type="entry name" value="MANNOSYL-OLIGOSACCHARIDE ALPHA-1,2-MANNOSIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01532">
        <property type="entry name" value="Glyco_hydro_47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00747">
        <property type="entry name" value="GLYHDRLASE47"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48225">
        <property type="entry name" value="Seven-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="315"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="6">
        <location>
            <position position="418"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="460"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="546"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="8">
        <location>
            <begin position="375"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR601382-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW77965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="560" mass="63687" checksum="6690966A5F731BA1" modified="2019-01-16" version="1">MAAYQPLFSSEKDSDDVLQYPSTVDQLKRPFAPWRPRSLKFPSFWTRQFRFLVCTLALFLLWIFILPLDFATRSHGIQHIFGPESATARAVRIDRQRQVRDAFVHSWNGYKKHAWLHDEVMPLTGGSRDPFVGWAATLVDGLDALYILGLEEEFNSSLKALELIDFETPKSDRVPVFETTIRYLGGLLGAYDISNGTHPVLLQKATQLGDFLFRAFDTPTGIPVPYYAWNNTEANRWDGENGVLIAQIGSLSLEFTRLSQLTGNRKYYDGISKVMGYLERAQNSTRIPGLWPAQVSTTDPPNFDGTAFTLGAWADSLYEYLPKYLRMYQYALSSAKRYHFFRPNIPHNPDILFAGSLSGVGDVPRLKSEVQHLGCFVGGMVALGSRINNSPSELKMAGKLTESCVWAYKNTPTGIMPEIFYVNPCPEKGPCVWREEPLKTPWGPNGMTKVFDATYSLRPEAIESVFIMYRLTGDKLWQEKGWEMFQAVMKYTTTEIANAKLLNVMDPKSKTVDSMESFWLAETLKYFYLLFSEPDLVSLDEFVLNTEAHPFRQRSGLFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVX0</accession>
    <name>A0A3D8RVX0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial</fullName>
            <ecNumber evidence="11">1.14.15.45</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">2-methoxy-6-polyprenolphenol 4-hydroxylase</fullName>
            <ecNumber evidence="11">1.14.15.46</ecNumber>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="primary">COQ6</name>
        <name evidence="13" type="ORF">BP5796_05942</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">FAD-dependent monooxygenase required for two non-consecutive steps during ubiquinone biosynthesis. Required for the C5-ring hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 4-hydroxy-3-(all-trans-polyprenyl)benzoic acid to 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoic acid. Also acts downstream of coq4, for the C1-hydroxylation during ubiquinone biosynthesis by catalyzing the hydroxylation of 2-methoxy-6-(all-trans-polyprenyl)phenol to 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol. The electrons required for the hydroxylation reaction are funneled indirectly to coq6 from NADPH via a ferredoxin/ferredoxin reductase system.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 2-methoxy-6-(all-trans-polyprenyl)phenol + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 2-methoxy-6-(all-trans-polyprenyl)benzene-1,4-diol + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81183"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10858"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84166"/>
            <dbReference type="EC" id="1.14.15.46"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + 2 reduced [2Fe-2S]-[ferredoxin] + O2 + 2 H(+) = a 3,4-dihydroxy-5-(all-trans-polyprenyl)benzoate + 2 oxidized [2Fe-2S]-[ferredoxin] + H2O</text>
            <dbReference type="Rhea" id="RHEA:81195"/>
            <dbReference type="Rhea" id="RHEA-COMP:9514"/>
            <dbReference type="Rhea" id="RHEA-COMP:10000"/>
            <dbReference type="Rhea" id="RHEA-COMP:10001"/>
            <dbReference type="Rhea" id="RHEA-COMP:10930"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:33737"/>
            <dbReference type="ChEBI" id="CHEBI:33738"/>
            <dbReference type="ChEBI" id="CHEBI:64694"/>
            <dbReference type="ChEBI" id="CHEBI:78396"/>
            <dbReference type="EC" id="1.14.15.45"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="11">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="11">Mitochondrion inner membrane</location>
            <topology evidence="11">Peripheral membrane protein</topology>
            <orientation evidence="11">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the UbiH/COQ6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.15.45" evidence="11"/>
    <dbReference type="EC" id="1.14.15.46" evidence="11"/>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVX0"/>
    <dbReference type="OrthoDB" id="683240at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120538">
        <property type="term" value="F:2-methoxy-6-polyprenolphenol 4-hydroxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106364">
        <property type="term" value="F:4-hydroxy-3-all-trans-polyprenylbenzoate oxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016712">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000021">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000245">
        <property type="entry name" value="Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03193">
        <property type="entry name" value="COQ6_monooxygenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018168">
        <property type="entry name" value="Ubi_Hdrlase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010971">
        <property type="entry name" value="UbiH/COQ6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051205">
        <property type="entry name" value="UbiH/COQ6_monooxygenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000689">
        <property type="entry name" value="UbQ_mOase_COQ6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01988">
        <property type="entry name" value="Ubi-OHases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43876:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS MONOOXYGENASE COQ6, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01304">
        <property type="entry name" value="UBIH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0274">FAD</keyword>
    <keyword evidence="3 11" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9 11" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="8 11 13" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="7 11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0830">Ubiquinone</keyword>
    <keyword evidence="4 11" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <feature type="domain" description="FAD-binding" evidence="12">
        <location>
            <begin position="48"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW78090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="495" mass="54172" checksum="E7FDC86F9FA23D7B" modified="2019-01-16" version="1">MNPAPSISRALRARQLNNYICNSCTQQIRRQRRSYVSTSSTLKSPEIYDVVCVGGGPAGLSLLAALRSSAATSGLKVALIESQDLSRTRTWDLPEGQFSNRCSSLTPASVKFLEGIGAWQKLRKERVQEYEEMQVWDGVTGARIGFEWMEPSNGTGEGKGRTIAYMNENANLTRGLLERIDELGGVDIYDGQKVEGIELGEESEDLDLRSWPVVELADGRRMAARLLVGADGQNSPVRTFAGIDSRGWDYNRHGVVATLLLDGQANRKTAYQRFLPTGPVAMLPMPGAFATLVWSTTPALAAKLKSLSPIDFMALVNAAFRLSTTDLAYMHTLEAGQVDELIWREKHTPFDVQHVPARVIGVQEGSVASFPLKFRHADTYIGERVALVGDAAHTIHPLAGQGLNQGQGDVESLVRNIVYSVTHGMDIGAQMSLETYVADRYTKNHILLGVCDKFHKLYSVESGPVVGLRSLGLRAVDAMTPVKQFFMRQAAGQGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVX9</accession>
    <name>A0A3D8RVX9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_06074</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVX9"/>
    <dbReference type="OrthoDB" id="3515484at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW78222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="143" mass="14628" checksum="8D3F153017388639" modified="2019-01-16" version="1">MLATASILSLVSGSALPIESELVARKALGGPAIANIAVYPSYKCTGPSTAPPYDATIKSISVTEEICQVLSVPLGSAVSANLTQTPKTGVAGCYINFYKTGSCAVSFDNYYVGYAFQGTTVGSKLPCVNPMGGAKGAIEITCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RW32</accession>
    <name>A0A3D8RW32_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GTP-binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_06131</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the GSE complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RW32"/>
    <dbReference type="OrthoDB" id="10020193at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11384">
        <property type="entry name" value="RagA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.190:FF:000003">
        <property type="entry name" value="Small monomeric GTPase (Gtr1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000488">
        <property type="entry name" value="Small monomeric GTPase (Gtr1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039397">
        <property type="entry name" value="RagA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF1">
        <property type="entry name" value="RAS-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="40"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="66"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW78279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="405" mass="45113" checksum="D0128DA8F507FC79" modified="2019-01-16" version="1">MGQEVSEEQGPSARADTSTAGGSKLTSLIAQARASANAIPRYDPAYHSSSSASDSDDSSDLDRTMDNLNLQDENSASSPAAEPRKQKKKKVLLMGKSGSGKSSMRSIIFSNYVARDTRRLGATIDVDLSHVKFLGNLTLNLWDCGGQDAFMENYLSQQRQHVFSNVGVLIYVFDIESRDFDRDLLTYRSIITALSQFSPTSSIYILVHKMDLIVPQQREELYTNHVQLIRSKSESFDPVAFATSIWDQSLYKAWAEIIHDLVPNLAEIEQHLSSLGILLQAEEVLLFERSSFLVVSSWASEVGAMNPTTDRFERLSNIIKNFKQSTSRFTGTPKSAEQFSLFELKMVVFSVFIVKFTTNTYLLVVLPPGEERFNCALENARLAVKEFESLDSPARRGVERGAGEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWC6</accession>
    <name>A0A3D8RWC6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_06199</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWC6"/>
    <dbReference type="OrthoDB" id="10298620at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017813752" evidence="2">
        <location>
            <begin position="29"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW78347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="173" mass="18934" checksum="2C80185BAE4025EB" modified="2019-01-16" version="1">MRATTSKSSLQSLLIFAISLSTLPIISAAPAISLDSLPAGTVVRLIHLGGAKSSERLNTSAYTDITAPYAESEEHTGTIGETKKVEDSSSEPKHSLPPLDTEVESHKYVALMKEIQNRQMVMSRMGHMNEIQPRDIVSPGWRAKVPLKGQGEGFVQIDMEDASYYQTLQDAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWZ2</accession>
    <name>A0A3D8RWZ2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">beta-glucosidase</fullName>
            <ecNumber evidence="4">3.2.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_06358</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 14">
            <text>Hydrolysis of terminal, non-reducing beta-D-glucosyl residues with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.21"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; cellulose degradation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.21" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWZ2"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008422">
        <property type="term" value="F:beta-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009251">
        <property type="term" value="P:glucan catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1700">
        <property type="entry name" value="Glycoside hydrolase family 3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.300">
        <property type="entry name" value="Glycoside hydrolase, family 3, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050288">
        <property type="entry name" value="Cellulose_deg_GH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026891">
        <property type="entry name" value="Fn3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002772">
        <property type="entry name" value="Glyco_hydro_3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036881">
        <property type="entry name" value="Glyco_hydro_3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001764">
        <property type="entry name" value="Glyco_hydro_3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036962">
        <property type="entry name" value="Glyco_hydro_3_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42715:SF10">
        <property type="entry name" value="BETA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14310">
        <property type="entry name" value="Fn3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00933">
        <property type="entry name" value="Glyco_hydro_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01915">
        <property type="entry name" value="Glyco_hydro_3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00133">
        <property type="entry name" value="GLHYDRLASE3"/>
    </dbReference>
    <dbReference type="SMART" id="SM01217">
        <property type="entry name" value="Fn3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56988">
        <property type="entry name" value="Anthrax protective antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52279">
        <property type="entry name" value="Beta-D-glucan exohydrolase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017713520" description="beta-glucosidase" evidence="10">
        <location>
            <begin position="20"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="11">
        <location>
            <begin position="451"/>
            <end position="594"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012744"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW78506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="870" mass="93861" checksum="59441C85D2CF9D02" modified="2019-01-16" version="1">MVQLKDIGLVAALTACVGASTTNATNRPWLDQSRTTEDRLKLFMQQLNETQKYAMVQGDTVLEDNGTGVSACIGHISGNSTLGVPAICMGDGPAGVGNSLDNVVVAASWNTSLQYFYGQALAQEHKSKARNVVLAPTINILRTPLWARAAETLSEDPFLTARMAVASTLGIQSQDMLACPKHFAAYNQDTDRFGLDPVWTAWDSIVSKRVLHELYLPAFKASVQEGKAASIMCSYNRLNGHYACENDWLLNTVLKGDWGFEGYVVADWYFSVRSTVAAVNGGLDISMPGGSLEDSYGFPAYYGELLVDAVNNGSVNASRIDDIVARLWRPMFEFGVVDAEVTGSSVAYARTQAHLDLAQAMVEDGSVLLKNEEAVLPLSPDKYTSIAIFGVDATNSSQVSENHGGFVIDSTMVVQSPLDSITARAAQDNITVSYSEGYPGTGQFPTIPSHMFGDGLNVTYWTTTDFSGPVNQTLIMPNITAALFPTDLWVAYPQVFSSRYEGFFTPNTSGLYHFSLTGQGDATLWIDGVEVGSMVKANFGNTVQATANLTANVTVPIRMDYSMGYSLSTGAYGITLGVDVGDTSRYPEAIALAAKSDISIVFVSDRWSEGNDNNLGLKLPGDQDALISAVAGASRRTIVVAQTNSAILMPWINDVDAIMEAWYGGQQIGLGLARLLFGDINPSGKLPFTMPKALNETPVASPERYPGVNLEAHYDEGLYVGYKWYDEFNVEPLFPFGHGLSYSNFSLSALNVRFGNDSSTNSSQILSTVQLSNNGGLAGKEVVQLYVSYPEAADEPPKLLRGFSKVFLEAGESREVTISVGMSDLMIWPEAIEDWTLVSGTYTFLVGFSATDIILSQDIYIGASGNYTSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S470</accession>
    <name>A0A3D8S470_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="7">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_05589</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="7"/>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S470"/>
    <dbReference type="OrthoDB" id="5958943at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09616">
        <property type="entry name" value="Peptidase_C12_UCH_L1_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.532.10:FF:000008">
        <property type="entry name" value="Ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.30">
        <property type="entry name" value="TolB, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011042">
        <property type="entry name" value="6-blade_b-propeller_TolB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000033">
        <property type="entry name" value="LDLR_classB_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF41">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00135">
        <property type="entry name" value="LY"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63829">
        <property type="entry name" value="Calcium-dependent phosphotriesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="8">
        <location>
            <begin position="358"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW80891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="598" mass="64625" checksum="C04084DEDF5BA38A" modified="2019-01-16" version="1">MGSITQGRLYFLDVNLSAFPNQNGRILSCNPDGSDLTELVTGMKYMPDGIAADAENGHLYWTNMGASMSNPDDGSIQRCDIATGQNITTIVPTGILHTPKQLTLARPDNGPPSLYWCDREGMRVMRCGLDGSNVEVLVQTGAGAKDRADKRNWCVGIAVDTQAGLVYWSQKGPSKGNQGRILRAPTCLPKGQKPDSRTNIEVLLDGLPEPIDLHLDAAGKNLYWTDRGDPPRGNTVNTLALDHGTANAKASSKERILTRKLHEGIGLAIDEANEMMYFTDLAGGVYSARLDGTGKKTLHEDVGDCTGIAFVPARRQRTPLLLAGFVGMSALFIGLKWQAVLQRSEAAKKAGTKDINYSVAPNRSENNPQALNQLSHELGLPTNLSFHDVYSLTEPSLLSLIPRPVHALCVIIPLTPAWHASRVEEDTPLDTYQGKGEQEPVLWFKQTIGHACGSIAMIHCCLNGAVRSQLTPGSELERIATVAEPLKMKDRAHVLWSSTALEEAHRAAAALGDTVAPDNQSADKLGQHFVAFVKGKDGHLWELEGSRKGPIDRGLLADDEDLLSPNALKLGLGRVIEMESRDGGDLRFSCTALAPSLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S4A9</accession>
    <name>A0A3D8S4A9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peroxisome assembly protein 12</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Peroxin-12</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">BP5796_05639</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18 19">BP5796</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="15">Component of the PEX2-PEX10-PEX12 retrotranslocation channel, composed of PEX2, PEX10 and PEX12.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pex2/pex10/pex12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S4A9"/>
    <dbReference type="OrthoDB" id="107372at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990429">
        <property type="term" value="C:peroxisomal importomer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005778">
        <property type="term" value="C:peroxisomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016562">
        <property type="term" value="P:protein import into peroxisome matrix, receptor recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017375">
        <property type="entry name" value="PEX12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006845">
        <property type="entry name" value="Pex_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888:SF0">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12888">
        <property type="entry name" value="PEROXISOME ASSEMBLY PROTEIN 12 PEROXIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04757">
        <property type="entry name" value="Pex2_Pex12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038074">
        <property type="entry name" value="Peroxisome_assembly_p12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pex N-terminal" evidence="17">
        <location>
            <begin position="25"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="308"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00029692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00034505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="RDW80941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="434" mass="49001" checksum="772FC5E30F951E3E" modified="2019-01-16" version="1">MDFLPTLQQAIDEQKPSLFELLSSTQLSSLIPPSLRYLLAVATHRHPRYLLRILNSFDELYALLMLLVERYYLSTYGGGFTENFYGLKREKCLRVGEISRASVAAPAVVRETLELRKGDIWKNLAIMVGIPYLKRKLDESYDINAPRALLGANYTRLPPNPTLKQRFLHYYRWFLRNIYPSINAAYYFATLAFNIAYLFDGSKYHDPFLWLVGTRMRRMGQADYQAIATAMEAAAAKSEGGSGLGTTSILHPRVLGPRLLGSLRLLLPTSIFALKFLEWWHASDFARQLSRKAAEGIELPPPVISGLSLLNTNSTPSTKSTDQVSTEKTDEVEPQRPLLSSVTLLPIYTVPVPEDKSLCPICEQDITTPTACQTGYVYCYTCIHRWIEGNHEKQEYFLDRASGRQGKWESGKGRCAVSGRRVLGGTEGLRRIMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SA38</accession>
    <name>A0A3D8SA38_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04634</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SA38"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW83143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="435" mass="49223" checksum="B77CC0236BEAB129" modified="2019-01-16" version="1">MCDWCRVETEGQGEDQIVEKGLDYVSNFDGGLSRSRKNKLAEEIDSLSDKPKNASRVLVKSPGGLKDYMRHEKRAEIRSNKLARNLPAQAQDSLEHLSLVQNASGSSVQEDGSNDNWRMSSADEAAGSGVESVKQQTYISIFDPIREPSFRPSNTKPLPKWMSLLPTNVHRCHGKRTKHAPIQRRTHRHGQYPPDEQDCVHRNPAAAVTEAGSLHQTHLTQVPQSAERQHDSSCSENCSSQERINRAKTTRNGRQELKPARRSQTSRSSYQTAFEHPVPLFISDQPAEVHRELHKKPSSCFFAPNHHDGVSCQGACYGLELQPSKPKPESVESSRIELSLQSSFRPSGPVVANSSEYVDRYQPKTQDPNYRSYVAKDVEPIMDRIRKQRTRKLDDGSEESKNKKTAIMKLIEDEFRTDPKRGDLNRELKNLFSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAC6</accession>
    <name>A0A3D8SAC6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_04766</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAC6"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791:SF65">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43791">
        <property type="entry name" value="PERMEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW83275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="225" mass="25051" checksum="F0044C604E5ABA39" modified="2019-01-16" version="1">MSTMLAKSVSLNGRSERQDLSSGSTHDSSDDLKGPTIMIKPEEGVVLPLGIPSTQGRFWFQRGKAIDSNAIATQPSIMGLLTLAVGLASFVLMPPSPTQTASTLRGNKGWFTAREETIIINRVIHEDQTKSGMHNRQSNTPKLLWQSLCDYDLWPLYLLRLTFQTPITTVNQYLTLNLKRFGFGTFQTNLLVIPWTVIHMFTMLGLAYLAEVWGELTFTAMVGQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAG3</accession>
    <name>A0A3D8SAG3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_04806</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAG3"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW83315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="172" mass="19237" checksum="4665FF54AF5C7918" modified="2019-01-16" version="1">MVRYSIASEGTADAEFSDGEGRKEGRKGHESLAWLLWAESAKWHGMLVKRNYPADHWNTQRWPSWYGPRADGVLAISAGDGQDLAMEKDERQDAKACTAVPPPNTVSEWQLREAQLLPIMGTTTGIGYEWPHTKRMRGFSFSIDIPMQVYVRIPLPPSLRSLAWLIAGALGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SH33</accession>
    <name>A0A3D8SH33_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cupin 2 conserved barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_03941</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SH33"/>
    <dbReference type="OrthoDB" id="5840532at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02231">
        <property type="entry name" value="cupin_BLL6423-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047142">
        <property type="entry name" value="OryJ/VirC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156:SF3">
        <property type="entry name" value="CUPIN 2 CONSERVED BARREL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36156">
        <property type="entry name" value="SLR2101 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW85616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="184" mass="20308" checksum="ACF0C8D4698A8A8A" modified="2019-01-16" version="1">MSATAPQPLLENGLPNVSRYITTHDTNGKAIIAKDVPAESVWQKIGSVAKFFLGYTTRTFPVAMSEQKDVGSYQKDLTSPPGLTVSTGTVLRYVDMAPNTISPMHKTISVDYGVVLEGPVELVLDSGETKLMHRGDVCVQRATNHAWRNPNDFWVRMMYVLISAEKEEGMQEDLGDMEDVKASE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHR6</accession>
    <name>A0A3D8SHR6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7888 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_04212</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHR6"/>
    <dbReference type="OrthoDB" id="3685327at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057210">
        <property type="entry name" value="DUF7888"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25411">
        <property type="entry name" value="DUF7888"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017669446" description="DUF7888 domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="DUF7888" evidence="2">
        <location>
            <begin position="66"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW85887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="185" mass="19217" checksum="06996990793EDA64" modified="2019-01-16" version="1">MQYKNVLLASVLAFSSLASALPSILSPRAGFPLQKRAVTVFTDGASASINPAISTTVFNPNDVGGKADAASAVADVLNKVVALVQGLIDGDTVRRQRFTQETVAAVKSQFPGKAVVMCNVGYTTTGTIDVVQKTSYKAKVGANVSFDVLVFGKGVTFTRSGDGGFQNWAYNLITGCTANGANLVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SI21</accession>
    <name>A0A3D8SI21_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">BZIP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_04146</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SI21"/>
    <dbReference type="OrthoDB" id="2245989at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021833">
        <property type="entry name" value="DUF3425"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116:SF9">
        <property type="entry name" value="BZIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38116">
        <property type="entry name" value="CHROMOSOME 7, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11905">
        <property type="entry name" value="DUF3425"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="38"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="202"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW85821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="375" mass="42381" checksum="7069C0585B255A0E" modified="2019-01-16" version="1">MTALTTITRHQRHYSHESTMNDQNDKEERKREYNRLAQREFRRRRKEHMKNLELAQKEQNTEQSEEIERLRYQNEELRRENEALRTQLYGTPSHNLSVPINIPVSSDGRQYSLSPSISGTSLSGHGSPPTSLGADMMPISALSLTSSMITPPMQAYTEPTNLSLSQPYSMVHPSGIRHNSQSSPESSGFKSPRRTSMGPPFQSLNSMTSVEQPRRASGPLLVAVPCDRNKARVEMQQKFRALLSDPATRANPSKHLSVLQSMSSTLPSSLQPSKAQLDTPHYYGIDMLASPSLRERLLNVTPDIAQSFISEAGSLIGESEDVGQVIVWGDDPLNEVSWEFSQTILERWGWLLGKEWVVRANFWRRQRGAAPLPDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SLQ9</accession>
    <name>A0A3D8SLQ9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative amino acid protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_02934</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SLQ9"/>
    <dbReference type="OrthoDB" id="3900342at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015171">
        <property type="term" value="F:amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004841">
        <property type="entry name" value="AA-permease/SLC12A_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004840">
        <property type="entry name" value="Amino_acid_permease_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050524">
        <property type="entry name" value="APC_YAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341">
        <property type="entry name" value="AMINO ACID PERMEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43341:SF1">
        <property type="entry name" value="GENERAL AMINO-ACID PERMEASE GAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00324">
        <property type="entry name" value="AA_permease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006060">
        <property type="entry name" value="AA_transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00218">
        <property type="entry name" value="AMINO_ACID_PERMEASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="238"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="293"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="358"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="402"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="435"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid permease/ SLC12A" evidence="8">
        <location>
            <begin position="1"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW87240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="505" mass="55491" checksum="3C21FB5D2F4FDA9B" modified="2019-01-16" version="1">MMISFGAGIGTGLWVGTGSALAKAGPAGIAVTYTIMAGMVYLMFVSVGEMVRRMPFLPFALALLGEISLIAASRQSMEYTDPAMGFANGINYWFSWVMIIPAEITACVSVLEFWPQTSVVPLAGWISIILVLIIIPNLFHVKIYGHVEFYMSLVKCVTILGMIMFMFIMASGGIAATGGPLVFHYWKIPGGFHNGLKGICASFIQAAFSFGGGDYIAIIAPEVKEPRETVRATIGPLFWRMASFFVLNIWLVGMVVPYDDVDLINKSGTLASPFVIAIKRAGIMPLAHVLNALIFLTVLSCGITSIYIASRCLSGLSELKLIHPLFDKKDKAGRPYLALIVSTTLGGGLCYLNCNNTAAVVGIAGFIQYALVYNNLIRFRMGLKAQGIDYKKLSFYSRCAPYLQYIGLVFIFLILAAEFYLSVFPFGAKPSASNFFASYLAAPLFVFDYFAYKWWFKTKIVKPIDMDFSAAAYFDYEEQCKAEEKMANPPPKLSLWKRVLAKVVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SLZ9</accession>
    <name>A0A3D8SLZ9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_03037</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SLZ9"/>
    <dbReference type="OrthoDB" id="446890at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140824">
        <property type="term" value="F:thioredoxin-dependent peroxiredoxin activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000010">
        <property type="entry name" value="Glutathione peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029760">
        <property type="entry name" value="GPX_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF78">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000303">
        <property type="entry name" value="Glutathion_perox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00763">
        <property type="entry name" value="GLUTATHIONE_PEROXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 8 9" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="5" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="7">
        <location>
            <position position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000303-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW87343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="171" mass="19100" checksum="6CC3BA15F4C714FB" modified="2019-01-16" version="1">MSSATSFYDFKPLDKKGNAVPLEDYKGKVVLIVNTASKCGFTPQYEGLEALYKKISAEHPDFVILGFPCNQFGGQEPGSDEEIQSFCQINYGVSFPIMGKTDVNGDKASPLFEWLKSEQPGLLGMKRVKWNFEKWLVGRDGKVKGRWASTTKPESLEKPILEALKEPKSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SM04</accession>
    <name>A0A3D8SM04_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Integrase zinc-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SM04"/>
    <dbReference type="OrthoDB" id="2499658at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="247"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="411"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="427"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW87306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="485" mass="53878" checksum="F38A3BA2F2AF2009" modified="2019-01-16" version="1">MSAPQQDNLNTVNTEKKELKSTNYQFDNREAAKIVFRCPQPFNPQFPSVNAYRQLLVDWYLQFGKRQWLHIKNQELHDTVITELSNPGSTIPWQYGNDDHKAQWKNYVKTAYRWEMTCQNVLGLVTTAESARAKELGRLPRPLMALESTYLGLCTYHTNGQGHHLGRDATLKALDNAPGEDWAIKKSLVAAFIRECPQCSGRLRKRATNDDKTAENSTTPGASEPKTNKRRAPSSEAGPAPKRARTQMASVTPSTNNGSAFGQGRPLATNANNDFANNLHAPPQSMQQLEMPVANTGINHGINYMPFEQPAAVDNYWNPVPRQQAGPYQAGAYQAPYLQQHAAPAASPDYYAAASQGAAIIPFYAAPPQVAYPIANAGAQLVEEYPTPPISRHGGSGPSRRSFTQLLGDMEEVEGEEEQEEEEEREEGEKGEEGRSGEGEREDQAREEEDGIEASLETYLDMFLGEEKAKEEDGMDLIDWSKTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SM35</accession>
    <name>A0A3D8SM35_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">NACHT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_03079</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SM35"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001638">
        <property type="entry name" value="NACHT and WD40 domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007111">
        <property type="entry name" value="NACHT_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056884">
        <property type="entry name" value="NPHP3-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039">
        <property type="entry name" value="AMELOGENIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10039:SF14">
        <property type="entry name" value="NACHT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24883">
        <property type="entry name" value="NPHP3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50837">
        <property type="entry name" value="NACHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="NACHT" evidence="3">
        <location>
            <begin position="416"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW87385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="877" mass="100316" checksum="2248CCF0F95EE0F0" modified="2019-01-16" version="1">MPKRRRNKSQKNTASKRQRRSRESEDKTASLNNGSLLKNDKALGDLLELAFNFVIETLADLDVFQDSSTSIFLVYAHENEKLPQLEAKAKQVQMIIKWLLQLRSKTISDRSPLFRDSISVRDTGKSGAHNILENQYCLLPRSSTSIKANEVSSIDKVILCSSEVLQLYYEDTEMQKYITDMKAFYGGQKPSRTNTFLNREELETGLHEIVKKYMKSTSFHHVITEIALLKIRQEEDSCKSIVPLILNGDHPSWLPVDEVDIWLGLSDISEDWVIHETQILHKMFFKLLRRIFEDLDGCICLFEDCYDKYVTRLSPKCNSSLPSEQGFRNEVKTGMSNVLTRLIDGNLAICRQTRKTSDRSNHEDKEYMKALFVTDPRGDKIRIQETKGGLLEDSYRWILENAEFKQWRENDDDENRLLWIRGDPGKGKTMLLSGIIDELDKSADTSFLSYFFCQAGDSRINNATAVLRGLIWLLMIQQPSLISHIQGEYDFAGKTLFEGPNAWVALSKIFTNILQDPSLKNSVKSTYLVIDALDECVTDLPELLSLIIEKSSETSIKWIVSSRNWLSIENQLEVLGQKVTVRLELNSQSISTAVQKYIKYKVRQLAQSMKYNSETKSAVQDYLSLNADDTFLWVALVCQNLKTIPRWDIGEKLKTVPSGLDSLYERMLQQIFDSGGRYIRILAFVAITRRPITLKELSSLDETLEEFSDDVESLTGIIGCCGSFLTLRESTIYLVHQSAKDFLLRNEKASNIVFPSGIANVNYRIFSRSLEIMTKTLRRRDIYGLHDPGFPIGKIEQPDPDPLAKTRYSCVYWVDHLDNCDRTRNATNDLQDGGSIDMFLRKSYLYWLEALSLLGSISEGVSSITTLEEILQVSYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMB0</accession>
    <name>A0A3D8SMB0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_03015</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SMB0"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF177">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="48"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW87321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="130" mass="14047" checksum="A154E1459B58D6D8" modified="2019-01-16" version="1">MTTLDASTSIFQSVVWPPLPSCLPSRPLKAVKLADATLKEKLLQMGPLGTVLIMGALAALLLALQYGGIAHAWDSSVVIGLLVGFVVIVLSLMIIEIRQGGSGTSKRLYVRVLSLRKGHLNRIVPEYQKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMB8</accession>
    <name>A0A3D8SMB8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">2-(3-amino-3-carboxypropyl)histidine synthase subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_03159</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 7">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the DPH1/DPH2 family. DPH2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SMB8"/>
    <dbReference type="OrthoDB" id="449241at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11860:FF:000001">
        <property type="entry name" value="2-(3-amino-3-carboxypropyl)histidine synthase subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010014">
        <property type="entry name" value="DHP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00272">
        <property type="entry name" value="DPH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01121">
        <property type="entry name" value="Diphthamide_biosynthesis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00408">
        <property type="entry name" value="Diphthamide_biosynthesis_famil"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7" id="KW-0408">Iron</keyword>
    <keyword evidence="6 7" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="4 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="410"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="529"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="423"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="438"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="469"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW87465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="551" mass="60828" checksum="F11C24B966965E43" modified="2019-01-16" version="1">MTQQISAAPVLSTPETHIFEDPTPIVTPANTVPLSDDELFEIYEVERTAREVREGGWSRIALQFPDAMLKDGPRVSQALEKELSRLPRPDLSASTGKNATVEELETDISKLSTNGKAERERLFILADTSYGACCVDEIAAEHVDADVVVHYGRSCLSPTARLPVIYVFTTRPLPLSPLVSVFENTYPSKELPVILMADITYNSHVPEIAEMLRAAGYTELLVPEIVHDPGSIIPNRSVDAELDIKDYSLFHISDPPPSLLLTLSSRVKDMHIYPTDTQAEPTSALEAQTSRTLRRRYGILTSLSTCPVFGILINTLSVKNYLPVIETLRSQITTAGKKSYTFVVGKVNVAKLANFSEIGGWVVVGCWESALIESSDFYRPIITPFELGLALMGDEERVWSGEWRSDFSDVLKNPPPEPAAQKETTELSSEKKENEHIEIEEDSEEESAPPEFDLRTGRYISHSRPMRMKTVTSESSKSEPTSASDVLTRRAKGDLATVNGIVSPGAEYLRTQRTWTGLGSDFADVEASDSIEEGRSGVARGYTVGEDGERR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SMF7</accession>
    <name>A0A3D8SMF7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">RTA1-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_03065</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SMF7"/>
    <dbReference type="OrthoDB" id="5384040at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF15">
        <property type="entry name" value="LIPID TRANSPORTER ATNI-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017558149" description="RTA1-domain-containing protein" evidence="6">
        <location>
            <begin position="19"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="107"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="250"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="295"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="332"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW87371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="397" mass="43842" checksum="5E61BC73CCBE6DA8" modified="2019-01-16" version="1">MLSKYMLLASTAIVMANALTTLAPTSTLNRVATQIVREAATITPSASTSQAVYFVSTKHITIPGVTNDHVTIAGKTIDIAIPTCTQTITPDANGYLPPGTCNALWDYYPSFSAAVVFAILFGILTLVHIYQAIVTRKRFCWVIIMACVWETCAFTFRAISTRFQQSAGVYLVFQIFVLLAPLWVNAFDYMALGRMIYFFAPARSLHSMPASTIAAAFVSLDFISFIIQLVGGSMAGPTSSAKDQLKAIHIYMFGIGLQEFFILVFVGVALNFQWQMSRLVNYEKDDGGRKGWRRLLYTLYFSLGMITVRILFRLVEFSRGSDVSNPLLTSEAYFYALEAVPMFLAILSLNITHPGTILVGVESEMPGFVATLRAMYPKKSFIKVGSGNDGEELLQRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SN79</accession>
    <name>A0A3D8SN79_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_03454</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SN79"/>
    <dbReference type="OrthoDB" id="4179406at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="164"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="452"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW87760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="532" mass="59197" checksum="35CDBADA6E1F8FD8" modified="2019-01-16" version="1">MPRGRHRAQLGDSWVVEGSEDEVNYEPGEEDLPTRTTRRHTRASNRSPEPEFVMPPLDPDTLEASWADNSSRSTRFRKRVNGDGIKVRRGPRQDRTPEKSPRLEAATPRSSVSSAGHTSSSPNATSDTNTSQDFFDAAIRHTGVMLSYALEVLGGALRILKTPVSILLAVYLLLGAGTLLQTLVTKSLYASLSPICRLPGTALLSLPFCPPPGTNAGENRPGSAEFDQLMTVQAKFDEVLEKSADGVSLPMDMKRGEASIRDLRQLVRYSQLQAKNELVLEFDGFIETARIASYDLQKFNSHVGRSVDSVIATTKWTTRVLDHIQLQDSGRGAISAFVNDKLLAPFQPTKFTERTVLDQYIKHTQIIEEEINTLIGEAQALLHVLNNLENRLEVIQGITTRDNVDVSAKREEVLAQLWTMVGGNRGKLSKMDRQIGLLHQVNVYQKQAFAHVAATLTRLQKMGADLENLRERVGAPELLQDRNIPLSVHIHQIELCVERLEQGRRNARKLEDAHIKENLERGKVDDSNLIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SNB8</accession>
    <name>A0A3D8SNB8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF7918 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_03476</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SNB8"/>
    <dbReference type="OrthoDB" id="3364132at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057678">
        <property type="entry name" value="DUF7918"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223">
        <property type="entry name" value="BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36223:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR EAF N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25534">
        <property type="entry name" value="DUF7918"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF7918" evidence="2">
        <location>
            <begin position="83"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="331"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW87782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="396" mass="43105" checksum="E0906E00652BC65A" modified="2019-01-16" version="1">MAILDICPGITVEILSNGNPLNEYADTDHYRTKLPAGIVSEAEKYQHSRMVSTYVCIPSSALPSASSAPSSGPGTAAQKLAPKFAIRMTVSPPYRMDTAKLRFDLAVDGIPVWTSHCARPDYNKLARTKTPWVEDVEGVKEGKGRGCTMRAFRFGKLDTTSEVDSSVMIKRQRMRMSKVGTITIHVHRVNYGKRGGGTIGNARHFLRGDEAIAEKALKGESKSHGTVLGKAQKATRGPVWTTDYKDGKERPLIIFSFLYRSEEALKHLLIIPRTPSPLPVPPATSDMSDAESGSMLVSGEENLDLNPSDLTPAQQRELAVLVAKMKRGNKSVGGNVKTERIGKRGKRTKAMKVKSESSGRDDRLSGRGRSVNVPAGEKIEIDLTGVADGDEDEDND</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SNI1</accession>
    <name>A0A3D8SNI1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bacteriophage T5 Orf172 DNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_03554</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SNI1"/>
    <dbReference type="OrthoDB" id="3549465at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053006">
        <property type="entry name" value="Meiosis_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018306">
        <property type="entry name" value="Phage_T5_Orf172_DNA-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 113 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28094:SF1">
        <property type="entry name" value="MEIOTICALLY UP-REGULATED GENE 113 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10544">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00974">
        <property type="entry name" value="T5orf172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacteriophage T5 Orf172 DNA-binding" evidence="2">
        <location>
            <begin position="320"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW87860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="539" mass="61373" checksum="A80D44358CF43160" modified="2019-01-16" version="1">MTTSPQGWSAPRLADILNQDHLKTWRCAGYNKTQSSSILQRCSNSIGAVDKGQIKVLLVDLKGNKNVLQSQYDLDQLLELSGLLLCKAVHRKSTAQARNIYDTWVQDIQKKPLQRNNEQLQNNTETLLSTKSLAQSSSSSSTITTVQKKLEIEDDATFRCRGLTSKRQRCKLSNRGTEEKIEGILKSIASETWSLTPRMRELLEELARLTLCERYHQDQAPLMVESWLQVIPRDIKQEKGLDPVPIPGIAPSLFPNRLTTRRQTRSMTTAASALEQPSEPIFEPFWPRSGCLSYRKFKEKALSPLSKTESRPGWIYAYTRPNCKHLKIGLSTNVSQRMNEWKKQCKYEPVLRFKVFTRNASRVEKLVHHFFLFERLRERLVNGGCNGGTGCTAKHEEWFDVPLEHAKRCVEVLKQWMKLEPYDQTGALKYTWAAAIKRFSLEASCNSIIELRLQILGDAMTEIKEEEDVKIKVESHYTLASSRPINISVRFPSIPRSGYPHTSLKTEGVSALTDSSLARRSSPRVLPHTPMPSLRAVYA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SPI5</accession>
    <name>A0A3D8SPI5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">P-type Cu(+) transporter</fullName>
            <ecNumber evidence="3">7.2.2.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">Cu(2+)-ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BP5796_03402</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="17">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 17">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.8" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SPI5"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140581">
        <property type="term" value="F:P-type monovalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd02094">
        <property type="entry name" value="P-type_ATPase_Cu-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000001">
        <property type="entry name" value="ATPase copper transporting beta"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006122">
        <property type="entry name" value="HMA_Cu_ion-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00003">
        <property type="entry name" value="copper ion binding protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00942">
        <property type="entry name" value="CUATPASEI"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01229">
        <property type="entry name" value="COF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 17" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0186">Copper</keyword>
    <keyword evidence="9" id="KW-0187">Copper transport</keyword>
    <keyword evidence="14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 17" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="12" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="395"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="422"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="471"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="500"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="684"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="726"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1075"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1103"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="19">
        <location>
            <begin position="27"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="19">
        <location>
            <begin position="128"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="19">
        <location>
            <begin position="221"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="19">
        <location>
            <begin position="303"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00080126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RDW87708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1186" mass="125990" checksum="42286E3659F58D47" modified="2019-01-16" version="1">MAPTYLKVAPRESTSRPLSSATTAHMATTTVTVGGMTCGACTSAVEAGFKDVDGVGNVSVSLVMERAVIMHDPAKISAEQIQEIIEDRGFEAEVIATDLPSPAFNRGGDFDDEAISDEELETPSATTTTTTVAIEGMTCGACTSAVEGGFKDLAGLKSFSISLLAERAIVEHDSSVLSAEKIAEIIEDRGFGAEIVESQETAPVKSKKTRRGSFTKEEKVLTTTVAIEGMTCGACTSAVEGGFEDIDGILQFNISLLAERAIIVHDPSKITSEKIVEIIEDRGFGAQIVSTQSTTGGKANESTTSQFKVFGVEDAAHATMLEERLQSMPGVTSAKISLATNRLTISHLPTIAGLRALVELIETQGYNALVAENDDNNAQLESLAKTREITEWRRAFKTSFAFAIPVFLISMVIPMLLPDLDFGSLVVLFPGLYLGDIICLILTIPVQFGIGKRFYVSAYKSMKHGSPTMDVLVVLGTSAAFFFSCAAMIVSILLPPHTRPSTIFDTSSMLITFITLGRYLENNAKGQTSKALSRLMSLAPSMATIYADPIAAEKAAEGWDFAIASGKEPKTPTQQGNAAEEKVIPTELIQVGDIVILRPGDKIPADGTVTRGETHVDESMVTGEAMPVQKRKGNLLIGGTVNGTGRVDFRVTRAGRDTQLSQIVKLVQDAQTTRAPIQRLADTIAGYFVPFILALGLLTFATWMVLSHVLKNPPQIFVDEASGGKFMVCVKLCISVIVFACPCALGLATPTAVMVGTGVGAENGILVKGGAALETATKISQVVLDKTGTLTHGKMSVAKCDLVPVWGNSEWRKKMWWSIVGLAEMGSEHPIGKAILASAKEQLQLGPEDTIEGSIGDFKAAVGKGINALVEPATNAERTRYRVLIGNVKFLRDNNVDVPTAAVTSSEEANVNASNSAKAASAGTTNIFIAVDGLYSGHLCLSDVVKDSARSAIAALHHMGIKTAIVTGDQRSTALAIARLVGIIPEDVYAGVTPDQKQSIIRKFQAQGECVAMVGDGINDSPALATADVGIAMSSGTDVAMEAADIVLMKSDKLMDIPASIELARSIFRRIKLNLTWACLYNIIGLPFAMGVFLPFGMHLHPMAAGAAMALSSVSVVASSLMLKLWSRPQWMEDALMEETGQLRKKGRGWGLGGMVGRAQDMMDSIAGKKGKEEGGYVPLRPMEQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYG4</accession>
    <name>A0A3D8SYG4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">R3H-containing protein-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_02489</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYG4"/>
    <dbReference type="OrthoDB" id="278430at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02642">
        <property type="entry name" value="R3H_encore_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.50">
        <property type="entry name" value="R3H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001374">
        <property type="entry name" value="R3H_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036867">
        <property type="entry name" value="R3H_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051937">
        <property type="entry name" value="R3H_domain_containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024771">
        <property type="entry name" value="SUZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672">
        <property type="entry name" value="CAMP-REGULATED PHOSPHOPROTEIN 21 RELATED R3H DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15672:SF8">
        <property type="entry name" value="PROTEIN ENCORE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01424">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12752">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82708">
        <property type="entry name" value="R3H domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51061">
        <property type="entry name" value="R3H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51673">
        <property type="entry name" value="SUZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="R3H" evidence="3">
        <location>
            <begin position="273"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="SUZ" evidence="4">
        <location>
            <begin position="337"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="100"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="214"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="341"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="418"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="583"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="748"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="108"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="214"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="343"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="375"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="449"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="583"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="629"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="651"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="748"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW91324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="784" mass="84625" checksum="E1DC3C8CB28F0721" modified="2019-01-16" version="1">MATAPMSTDTARMSFAKVAASGGKDNVALNSFTKVATSSKDLKKSATDENINPHIQLPASNDHEQRTAVTDSHESSINEKILVDAVKALKVHDQMPSLVVNGSGHPAASNNKSEVTESFSEDLFQRTDSGSELGTKPPSLDGKSITSGTTFALDEKDSLRPDDSASVKAAEDDDTFSGRGSIVAGSRIGSEAAARAYRSQLHDGADRKNMISLQEPQSQGGNTPPSGSSGQLPIDEAKGKPLTTAGTPDAFNLFYRQTPDEKLLEALESPKDRIFLLRLEQQVIEFVKDSKEPYMDLPPCNSFCRLLTHKLADYYHMTHQVDPATGTLRIYRTPFCRLPPSLTSISNPPTTGNTPPPNIPAMKIMRRGGDGDTGASASRANSENGSDGKNKGLSAKEKLSREEREAVYIKARERIFGKEDKTGEATPETEDGNEMSRSSSVSTKEKSGQTKRGKQGKHRRDDSDSFDVRSQYAPFFPQAQQQQPAWAPIHQYAPMGGQPFVPTVQNNFMNTMPAQYGPPQQFTPALANGGNIQPYNNMGQFPPANQRFQPQGAPNPVFGSPTQPVQTIPQQWAQSQGIYSSPYQQRSTMAGPQSSIPYAFGQLPTTANPADPKSQHPIPGSFNRHAFNPKTQSFVPGNSGVPVQQPMSHHGSPRHGSSHHGSPHLPYNNYAAPQPQFGNPPQFGNGMGYNMARQGSNNSLPSYHASPHMAHRPMMHQGMGQGMQSMSHGMPQNMPQGMPQAIPHVIPQGLPQGIQGLQPNGQVGSHLPNFGNSSTLPPKPPPAV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYJ1</accession>
    <name>A0A3D8SYJ1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cytochrome b-c1 complex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_02562</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the UQCRB/QCR7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYJ1"/>
    <dbReference type="OrthoDB" id="425749at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045275">
        <property type="term" value="C:respiratory chain complex III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006122">
        <property type="term" value="P:mitochondrial electron transport, ubiquinol to cytochrome c"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1090.10:FF:000001">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1090.10">
        <property type="entry name" value="Cytochrome b-c1 complex subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003197">
        <property type="entry name" value="QCR7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036544">
        <property type="entry name" value="QCR7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022:SF0">
        <property type="entry name" value="CYTOCHROME B-C1 COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12022">
        <property type="entry name" value="UBIQUINOL-CYTOCHROME C REDUCTASE COMPLEX 14 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02271">
        <property type="entry name" value="UCR_14kD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000022">
        <property type="entry name" value="Bc1_14K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81524">
        <property type="entry name" value="14 kDa protein of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5 9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW91397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="124" mass="14327" checksum="F8253144979AEDE6" modified="2019-01-16" version="1">MSAPSIANQITKRPWLKKMMMPLANWYANAAGYRKLGLRADDLIPEESETVLLALKRLPQKEAYDRVFRLRRAFQCSLSHQLLPKEQQTKPEEDTPYLSPIIAEIEAEAKERVDLEAMTISKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZ30</accession>
    <name>A0A3D8SZ30_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Fungal N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZ30"/>
    <dbReference type="OrthoDB" id="5431013at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="249"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="358" mass="40182" checksum="8F9801FD106BDD2F" modified="2019-01-16" version="1">MIDPISALGAASSVVGIASFGIQLSQALYQYISDARDYKLELNAIVNGVRSATDALEMIRDLLETEHQHICQHGQPILFTEKALMFVQEQGDQSLLLFWRIENEITKRHGSEALEVHLARRLDEYHNPKARNLGRTLQLDPDMTLSTKGQITWPLVLPKLKDYRMQLEQHQINLSLMLQVIQFASLQKTMKKRQEKSRQRENREKLIVQIQETAGKVHLPILDTIVDSTSASKAPESKKMHALHRRAKSSQDKDHLKSGETLNATPSPSTARENLHHPSSGVSTMAFATLIPDNNLEVFGEKSMLNNGTKSRVVNTPVERDETPIMTTTKSQLSSDDSSTESEASFIQSMSAFISFNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZ35</accession>
    <name>A0A3D8SZ35_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_02752</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZ35"/>
    <dbReference type="OrthoDB" id="3509362at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF7">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW91587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="513" mass="57059" checksum="D5BACCACD6AE07FF" modified="2019-01-16" version="1">MAAAAMNSPATQFSDTTIAVESDSKPKAKTQTKKRTGTTRLRTGCLTCRKRRKKCDEVYPICGHCTRLNLVCGREEPRALSPDPFIQGNNGGDVNAQVEKAVLQRRRFSILIPNPSPATILPPAHERSQRYLLKYYAQVLSMLCSTSVESNSFINVFMPMAMDSQPVLNSLLAWTAGHIKFFDESYSPVASEYRSAALVSLASALPSNANPDTTLAACLVLCAAASPTNHWYDHLQGAKSIIESASTTSPTGNLLTGTECFMQTPDGQWLLRHFAYHDVLGAVAMGTKPLIAGPYWLPRGGFILDAYVGVASEILAMISEICCLTYENTASQVALEWDSQDWMPEPSLEGFQSWYPLLDLESRITHWECPTTSQEYLVELAESYRLAALICLYRKARDFFPTDTPHINLRISQHVAELVRILESIPYQSMAEGGLLFPLFIAGGETMDDVSISIIRTRLQGLLAHRGFAHTGLSTEILEELWRLKKRDVKSPEGRNVDWLDILKRRGIKLMLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZ60</accession>
    <name>A0A3D8SZ60_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Disease resistance R13L4/SHOC-2-like LRR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_02616</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZ60"/>
    <dbReference type="OrthoDB" id="1394818at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050216">
        <property type="entry name" value="LRR_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055414">
        <property type="entry name" value="LRR_R13L4/SHOC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019487">
        <property type="entry name" value="RAM_signalling_pathway_SOG2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48051:SF1">
        <property type="entry name" value="RAS SUPPRESSOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23598">
        <property type="entry name" value="LRR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10428">
        <property type="entry name" value="SOG2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52075">
        <property type="entry name" value="Outer arm dynein light chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Disease resistance R13L4/SHOC-2-like LRR" evidence="4">
        <location>
            <begin position="142"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="227"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="264"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="341"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="404"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="594"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="649"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="894"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="43"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="418"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="606"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="662"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="894"/>
            <end position="908"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF23598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW91451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="937" mass="102148" checksum="93CD48B7FF1FF79C" modified="2019-01-16" version="1">MDAPSGPTGPLGAATQSSGRPMVANGLPARPGPRDSARRGPNSIRPAASNSSLSSQPSISAEKVVSLARDAMKVALDENQNKAAETSGVSNELKPGVTIDLSHKNIHKFPEEVVDIIKNELERLALSHNLISTFPLRFSECSSLRYLNVRNNVIREFPQPICELTSLEILDLGRNKLRILPPEIVKLTSLKVLSVQKNRIEDLPLCLADMTSLQVLKLDGNPIRFPPKEVLQPQATTPPNGPYQESEVDDVTITAQIKRFLKQKAITDRSETESGGEESSEGGAETPRPKRVVSGRFPIKVNGTDVPDLRSPALPRPPPPIPSRSHFRGLSQQNAALRNPGVMPLTIGSTNERVRSNSESLLAASRERQERAADRRRMGIVSRKASELGTVEESRSNRYSHYRGLSHGSAMQGPGAISSSRSPVSPADSVAQRATYVRRLSSLPERKRESNSPDPIIEGAKGILFALFQVHPLIQSLLGLARDSPNKRSSLERVFYNASTHVEELDRDIQNYDTYSEEDEEVPRSNENVHRACLTCVSAYIHVCSLLSRNVETLLNNGDPRYIRTLLLLVFGSLAEVRNAGASLYPQGQRQLMRSQPMEGETMRFQPRDKSVTPTRERPGVVPRLRSATVVQHSSSNLRVATDALPPPFLRSATMTSATPRSGESFGSSSTSGGRGGDFTEEDRLFERIFLRLQQSSEMAIRTLPSVTSHFVTAMKISSQQSNADQTRPPFWQILIQRCSIALQNAEALKARLSLIKLKEPGIRTQSAFWELCNAFINAYTDLVIKVKEAKNVTNLLPTDVIVLLRPLQKAVKETGQLIQASPWSFLASAGPANGMGTSPASQVPLPVTPQSAALGPAVQATVPSTPQSASFNAMFSGGVFERADTLLSINSSSLSSRTGTMSSSLGSHDGSMTPASMLSPMHSMNSRYNMGGKVMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZJ9</accession>
    <name>A0A3D8SZJ9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_01147</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZJ9"/>
    <dbReference type="OrthoDB" id="10623914at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017657654" evidence="2">
        <location>
            <begin position="19"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW91753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="165" mass="15696" checksum="DAD421B0E082A0D6" modified="2019-01-16" version="1">MKINSLTVLSFAAMGVHAMPVPLPGLVELPHIVSKVTTAGGPALAGCAKGSILIAGVCYKISVANSPTPPSKSPATSPSSKPAPVVGSSPQPATAPTSSSPYGSCGSSSSAACAGGSSSAKQPATSPQPPTSPQPATSPAPSSPYGSCGSASSTNCATGSSSSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0B0</accession>
    <name>A0A3D8T0B0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl CoA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_01380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ACBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW91986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0B0"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310:SF62">
        <property type="entry name" value="ACYL-COA BINDING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23310">
        <property type="entry name" value="ACYL-COA-BINDING PROTEIN, ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ACB" evidence="3">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW91986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="100" mass="10834" checksum="C4E332AC177E3943" modified="2019-01-16" version="1">MSDFETAVIDSKKLTSKPGNDDLLELYGLYKVATGEDITTSEQPGTFDLKGKAKKRSWQKIVDEGITSDEAKTRYVAKIAALKESCGYDADKAPEAVGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0E3</accession>
    <name>A0A3D8T0E3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_01441</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0E3"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW92047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="69" mass="7374" checksum="D64831DA24F3F030" modified="2019-01-16" version="1">MPSILRSSGASPKSSTRIRRCSSTAAVSLAAKPRRTGPMTIVLRVSLMNAPKLYGWLRRRKGGLPHAGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T0H3</accession>
    <name>A0A3D8T0H3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable cytosolic iron-sulfur protein assembly protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="primary">CIA1</name>
        <name evidence="6" type="ORF">BP5796_02673</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat CIA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T0H3"/>
    <dbReference type="OrthoDB" id="284782at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03037">
        <property type="entry name" value="ciao1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028608">
        <property type="entry name" value="CIAO1/Cia1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920">
        <property type="entry name" value="WD40 PROTEIN CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="141"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="189"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="271"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="355"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="355"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW91508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="441" mass="48318" checksum="78779541CFB9D4F1" modified="2019-01-16" version="1">MDKPGPQLVHLADFKPPSAARAWVSIPNPNGLPLIATATSEKTVRVYSLSNFTLHSTLEGGHSRSIRSVAWKPSTQDNGELCIATGSFDSTMGLWRRKEEGGALRAGGSGEPLELEVTRNGIKHDEEGSDDGEDWEFAIVLEGHDSEVKHVAYSPSGQWLASCSRDKSIWIWEEIGEEGDDEFETVAVLQEHTADVKCVSWRAASSYKDEGEVLASASYDDTIRLWREEEEGEWGCFAVMEGHDGTVWSLEWEPLVSVKRFDLEDGRPPRLLSSSADGTIRLWSLAPAAPSPNKPSYFNSGIPSTMRPAPAAEKWICTAVLPKVHDLPVYSISWSARTGQVVSTGGDGRVAIYEERKREPAETEAEPKPEETAESAKPSATTEWVVVTILDGAHGPYEVNHVTWCPRYDAGKKSADEELIITTGDDGLVKAWTVEGNPIES</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T152</accession>
    <name>A0A3D8T152_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_01623</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T152"/>
    <dbReference type="OrthoDB" id="10333325at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="300"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="412"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="629"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="630"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="665"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="703"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="730"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="841"/>
            <end position="853"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW92229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1199" mass="130753" checksum="54DDE93E208D95B1" modified="2019-01-16" version="1">MNPHRPNPLNSSWNTSEEDDNVSPLTSPVQIIASAVVSPLSPEVRTPQGPAIWIDPPQSSPANNTVPGRPDSGVDADENHLHEGLADEIIWRRQLGVETEMAEESAKGFDIPEPESLNESQPFEDLTPTQKKQNLLSAIQLTPRAQSSKDKQKELPENAVRELGATPDGITYDGVDFYQDGHVIRMTDIPQGAPLLSALTLAMQYGQYDKLVADYFALTGKTPFEFPAAGAKTTAPVDEPPQSASSVKTEDAEKVLPGVAATYNTLNDLKKAHLAGDGDWTEEQENLINDISTQMEALAAKKKKHQLEQSKNTYADSPTTPKGSAPTNKKLESAERDYVGLVLAKYKKPKSWDEDKEEKLNSAARKFERLNALRKERNATQTSLEPQPPGGHAEAARDGSLFSLGISYRKTAAPVSDSPKPSILQTIGIPSASGTSSKPDELSALQVNELNGIQEELSNLVYMYTNLEVQMKAACEGRQPSKTFIDKNENAREALRARRDELANRSNVILNSVSVKARFEWKNKKWQQMIDELYVKHDRLEDIKNQAARHDSKIAFTPELQEALDAVARGLDAAGEHQPTMEKEASPETCSQLPFVPTFDPIRSTAAALVSDPSSTKEDLKQQPLNILNKSEDTEAPDNHNRTTNVSGSTGGNNQNKGKGKDVGNRGNNQSSQGASGSNPQSNKGRGSDSPGSGDHKDKDGSQKSNQANPQSLFAPPPRRPSSKITRTVDPAHDVRSYRPDPPIEGYKDEDSDPKLIQASSQSLFAPQPKRPSADITATVDPAHFVRDNEPDPPSGGHGGNNGEADAQFLFAPLPRRPSSDITTTVDLALDVRDGQPAPPREGHKETSPKEFGPESSTEPGPKQPSPKPEVPKPSSSKKHDGVVPSDPDDGHHFVPTPKTLSADLSNNVPASDYLIPGQNPPQLEVSSRRRVKDIYSLRKQQLEAASQGEPDNLALQRELISPLSVLDVKPLSKAAKRLSKLFNDNIKGGNDKYLAPQKDWADLLNTLKKDQAASALAKGKYFDAEDRLAADASNEKLKEEVCAATEEKKAAISSLGKTEEKVECRADAARLRPEIIDTVFNSLVSSLGRLMNNSRWAEAWRIIQRMKQKAELEDDENRYSLMQGRISFWSGVTRWNCSTTSNNTLPAALEDFERAEACGIINDGSEEGKYLNTYTELCIAGTGPAEDKDVPVGPGTIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T183</accession>
    <name>A0A3D8T183_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Fungal lipase-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_01688</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T183"/>
    <dbReference type="OrthoDB" id="426718at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00519">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051299">
        <property type="entry name" value="AB_hydrolase_lip/est"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002921">
        <property type="entry name" value="Fungal_lipase-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640:SF1">
        <property type="entry name" value="FUNGAL LIPASE-LIKE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46640">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G06510)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01764">
        <property type="entry name" value="Lipase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Fungal lipase-type" evidence="3">
        <location>
            <begin position="151"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01764"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW92294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="340" mass="38439" checksum="4B4464C851E6EB18" modified="2019-01-16" version="1">MGNAHRQVPTPNLRNLKLTSDCSVPTTLTQEELNSMRLFAHYSGAAYCDSIYLDAEDFNIDCGREEGKCPLEHDPEPEVVDIMYHAGPDAGTGYIARDVPNKMIIVAFQGTADGITSKMRDRADDGLIANQFEADLKIIRRISPNTCLPQYMPVTKNGCEVHSGFWNSWTQMESFVEQALIQLRTEHADYKYVFTGHSLGGAIAALGATHFRNLGWVIDLYTYGQPRLGSSDISMYITGQAPLRGKNYRVTNWDDVIPQLPTYKWIRKTHWTHFAPEYWINSDTVDDYNITLGDITVVPDFLYSEKGNSQFNVLESIQHKNGKKHGHYFGDIAGCDRERK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T193</accession>
    <name>A0A3D8T193_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_01741</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T193"/>
    <dbReference type="OrthoDB" id="1001765at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd00657">
        <property type="entry name" value="Ferritin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012347">
        <property type="entry name" value="Ferritin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052965">
        <property type="entry name" value="Pigment-catalase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31694">
        <property type="entry name" value="DESICCATION-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31694:SF26">
        <property type="entry name" value="OS05G0151100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13668">
        <property type="entry name" value="Ferritin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017768446" evidence="1">
        <location>
            <begin position="20"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW92347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="329" mass="34940" checksum="5A7601A5D4375E68" modified="2019-01-16" version="1">MRSSFIIATFATAANLVSALPTVVEKRADFAAPPNGDIDILNYALTLEYLERKFYGDGLAKFGSSDFVAAGFPAPFYDNLKEVYFDEQTHVSFLAGALKDAGVKEATYSFPYTDAKSFVALASVLEGVGVSAYLGAAAAILNKQYLTIAGSILTVESRHSSYIRAALGESPFPKPFDTPLDFMQVYSLAAQFITGFPNSGGKSGLPFTAFPALALEASQYPYTAGSSPVTFKHAFNNAKALGVTADTPVYAVFFSGLDTYYVKTYITRGDSGDYKIKSIPGADFASAGQLPPTGQVYVVLSTADGVNTFVNDANTLSGVGVLEVLPPRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T226</accession>
    <name>A0A3D8T226_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nascent polypeptide-associated complex subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Alpha-NAC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_01875</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the NAC-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T226"/>
    <dbReference type="OrthoDB" id="3169036at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005854">
        <property type="term" value="C:nascent polypeptide-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22054">
        <property type="entry name" value="NAC_NACA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14358">
        <property type="entry name" value="UBA_NAC_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000002">
        <property type="entry name" value="Nascent polypeptide-associated complex (NAC), alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000006">
        <property type="entry name" value="Putative nascent polypeptide-associated complex subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016641">
        <property type="entry name" value="EGD2/NACA0like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21713">
        <property type="entry name" value="NASCENT POLYPEPTIDE ASSOCIATED COMPLEX ALPHA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015901">
        <property type="entry name" value="NAC_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NAC-A/B" evidence="8">
        <location>
            <begin position="45"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="108"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="108"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="122"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW92481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="207" mass="22385" checksum="19A8A9950B0BA7CB" modified="2019-01-16" version="1">MANPRIEEVEDDVPAQNVTADDDDSSDSEIETGEGIPAGGAIVHSRNEKKARKSIAKLGLTKIPGITRVTLRRPKNILFVINSPEVYKSPNSNTYIVFGEAKIEDLNSQAQSQAAQQLAAAESHDHAGHDHSGHDHSHDHGKGKAVDTSDDKKDEDEDDGEEVDATGLEDKDIELVMTQASVSRNKAIKALKENDNDIVNSIMALSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T2V3</accession>
    <name>A0A3D8T2V3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_01722</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000002">
        <property type="protein sequence ID" value="RDW92328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T2V3"/>
    <dbReference type="OrthoDB" id="5420387at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42345:SF2">
        <property type="entry name" value="HELICASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42345">
        <property type="entry name" value="TPR_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW92328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="954" mass="106184" checksum="A23F368102152E49" modified="2019-01-16" version="1">MPSFSFLKHPRSDSRQEVHDDGDANLSSRGDEKVQRRMSKRDFFRNLLKKPSVHVKGRDSRRQSVQVKTPDFQSPSTESAVTPASPMSDPNKPLPPTPPDAEIEEAHVLKRPLKLDRIIAPVTSLEVHKLFSGAPQFFDRSEGHHTGAPRPMVAYPWDEEVAVRDLCDHLQIQDAAWSSVTAARHITQDRSNNPAVMEAHQKKKQAHYHPRCRERPLMLSMQGIERGTMGFVAALEMGVADAQNEEEDFQDEKERSLIQRRRDFIYSKDGLRPFSESTLVDHLSRVTTNYREDPFNTRRTAVEMYTELFTQLLYPPSRVTDSDDPYSLQVQIEALLDVLGAPGIWIDFSIVEWRIRLGQILWGPQNSSYGADDVSINSEESLEPGAEKFWLLLQILLACELSIRLDAECQNIDLGKDSVRAASIQRFDKQATESVKWSMILARQWLEDIQIESVRPRSSAEQKVSSGWLATLKGATFHHIAHGHTDSIDNIQIRGRYQQRQLSGLLHFARKLQWPNVEHLAGKVASNGISMSESIQNTPAGGTPMSSTTQRSSSYFTARRPTIRRGISRPQKISSIMNPTGWLSNSYLSGLVLPGEGMSHFLISTLLENDDIAVARLGEEANLYGGFIFLDKSFWSMACIVGRVLAAGKGARECMGWVSSDVTPRGCGEGWVNIDIEAELPPNLYSDQGKPRIWEKTAVERDGNVIGDSDFSSVLPGDFVIPSDKPAKLPLITLESLDFFAATDSGLNTPTHEHTPYMEMSEASQIKTYSAMVRFSVDFGEEVKELHFALTHNIQFVTAHPCVPSNHTETLHSISSPTSPIFDSGTTGTLSGHPLHKFFSYTQVSLSTILSSPSKSYSTLVTPDDSLASELTVDDRPSKVLIIDCTSESEQISTTLPTNHKHHFGNDMEILVRALCAEKGWNALISRRGRGCIACAVREAGALGWGSGGVIVRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T6S9</accession>
    <name>A0A3D8T6S9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ClpP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_00055</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid beta-oxidation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Peroxisome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enoyl-CoA hydratase/isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T6S9"/>
    <dbReference type="OrthoDB" id="448450at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005782">
        <property type="term" value="C:peroxisomal matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004165">
        <property type="term" value="F:delta(3)-delta(2)-enoyl-CoA isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006635">
        <property type="term" value="P:fatty acid beta-oxidation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06558">
        <property type="entry name" value="crotonase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.226.10:FF:000048">
        <property type="entry name" value="3,2-trans-enoyl-CoA isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051053">
        <property type="entry name" value="ECH/Chromodomain_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001753">
        <property type="entry name" value="Enoyl-CoA_hydra/iso"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43684:SF1">
        <property type="entry name" value="ENOYL-COA DELTA ISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00378">
        <property type="entry name" value="ECH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0576">Peroxisome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW94292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="269" mass="29426" checksum="241CC173FF737FFF" modified="2019-01-16" version="1">MSSPVTVDYRGKIAVITINNPSKLNALDQDGYYALATHMRDIATHDEVFVTVLTGTGRYFSAGADVGISRALPDGTDLARHWLRNFVANNLNITHAFYTHPKILVTALNGPAIGLSAALIAFSDFIYATPHTFLLTPFSSLGLVAEGGASRAFVQRLGISKANEALIMSKRIPAEELLQVGFVNKIFDVEKGEDEKFRTLVFEEIENRLGSHLIGDSLTKIKALIRKPDRDVLDAQGVAEVFGGLERFSAGIPQEEFKKIASGEKRHKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T7T1</accession>
    <name>A0A3D8T7T1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Ribonuclease T2-like</fullName>
            <ecNumber evidence="4">4.6.1.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">BP5796_00396</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20 21">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Rnase which modulates cell survival under stress conditions. Released from the vacuole to the cytoplasm during stress to promote tRNA and rRNA cleavage and to activate separately a downstream pathway that promotes cell death. Involved in cell size, vacuolar morphology and growth at high temperatures and high salt concentration.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Vacuole lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 17">Belongs to the RNase T2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.19" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T7T1"/>
    <dbReference type="OrthoDB" id="435754at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005775">
        <property type="term" value="C:vacuolar lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033897">
        <property type="term" value="F:ribonuclease T2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01061">
        <property type="entry name" value="RNase_T2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.730.10:FF:000004">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.730.10">
        <property type="entry name" value="Ribonuclease T2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033697">
        <property type="entry name" value="Ribonuclease_T2_eukaryotic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001568">
        <property type="entry name" value="RNase_T2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036430">
        <property type="entry name" value="RNase_T2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018188">
        <property type="entry name" value="RNase_T2_His_AS_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033130">
        <property type="entry name" value="RNase_T2_His_AS_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057328">
        <property type="entry name" value="RNaseT2L_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11240:SF22">
        <property type="entry name" value="RIBONUCLEASE T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00445">
        <property type="entry name" value="Ribonuclease_T2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25488">
        <property type="entry name" value="RNaseT2L_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55895">
        <property type="entry name" value="Ribonuclease Rh-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00530">
        <property type="entry name" value="RNASE_T2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00531">
        <property type="entry name" value="RNASE_T2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 18" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0926">Vacuole</keyword>
    <feature type="signal peptide" evidence="18">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017674217" description="Ribonuclease T2-like" evidence="18">
        <location>
            <begin position="22"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="domain" description="RNase T2-like C-terminal" evidence="19">
        <location>
            <begin position="286"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="75"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00071169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR633697-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU004328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF25488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="RDW94633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="394" mass="41464" checksum="D641217C8021B90E" modified="2019-01-16" version="1">MSSFLAQAFVSALVLSPITQALGVAKTCSNPQLSCQNTTVVSDLCCFNAPGGQLLQTQFWDTNPVTGPSDSWTIHGLWPDHCDGTYDSNCDSARAYTNITSILESFGKIDLLSYMNTYWKDYQGNDESFWEHEWAKHGTCISTFDTNCYTGYTPTQEIPDFFQKTVDLFKTLPSYTWLSDAGIVPSSTATYTSAAILAALKAGFGYDVIISCSSSALDEIWYSYNVKGSIQTGTFVPTNPDGSKSSCPSTGIKYLPKTGATATATATSTGTATKTTTTATSTSTGSFSGKGYLNAVTSGSTTGCLISAGTWYTSGTCATYTATTSGNKGNCGISGSSFTCAFGVTATVFTASGGYLAYDGSTTFYAPAVPSGSTQEQVSTSSGSVEVQFAWQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T887</accession>
    <name>A0A3D8T887_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_00523</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T887"/>
    <dbReference type="OrthoDB" id="10267139at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043743">
        <property type="term" value="F:LPPG:FO 2-phospho-L-lactate transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10680">
        <property type="entry name" value="CofD-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002882">
        <property type="entry name" value="CofD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038136">
        <property type="entry name" value="CofD-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31240:SF0">
        <property type="entry name" value="MATERNAL EFFECT EMBRYO ARREST 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01933">
        <property type="entry name" value="CofD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF142338">
        <property type="entry name" value="CofD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW94760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="464" mass="50539" checksum="48E26AFD3404C1D6" modified="2019-01-16" version="1">MDSLPRLNFGATRSRIVVFSGGSAANNLVDIFGQVADDRGCSLSYDNGGSSSELIRVFGGPGIGDVRSRLVRLIPEDPRGSDTEKAAIKTFFNHRLSSSPSEARIEWLDIVESRHPLWAHIESSKRELIRPFLNTINLEIVKRARPSSVFNFQSASVGNLFLTGARLFTGSFESAIYLLGAITGVPGNVEVIPAINSNFSHHISAGLQDGSVITGQNAISHPSVPSAVPESPITTTRRLSKELSDHDRVEDANLPGSLPSLRKQNIEFHKEVTEDLPSRIERIWYINPYGQEIRPTPNSKVLEAIRQASCVIYSIGSLYTSIIPCLILRDVGDAIAAANVRFKILILNGSIDRETGPAHAPYGAKDFIAAVAGACWSSRGLKGVPSAERYKEFVTHVVHLQGEGTPRVEKDELTELGIETVRLYGRRGGGGMVYDGAALAQALAAIVGRRDPRMDRSRRNTLEH</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8A0</accession>
    <name>A0A3D8T8A0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vacuolar protein-like protein sorting vps16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_00507</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8A0"/>
    <dbReference type="OrthoDB" id="1792at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.780">
        <property type="entry name" value="Vps16, C-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016534">
        <property type="entry name" value="VPS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006925">
        <property type="entry name" value="Vps16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038132">
        <property type="entry name" value="Vps16_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006926">
        <property type="entry name" value="Vps16_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04840">
        <property type="entry name" value="Vps16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04841">
        <property type="entry name" value="Vps16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007949">
        <property type="entry name" value="VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101898">
        <property type="entry name" value="NHL repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps16 N-terminal" evidence="3">
        <location>
            <begin position="10"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 C-terminal" evidence="2">
        <location>
            <begin position="374"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW94744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="697" mass="78299" checksum="018D6AE2145DFD75" modified="2019-01-16" version="1">MPVSSFPGRFYGTGFVALLSNNHLIAVTRYGEPRPKLLAIPPDGEVHSWTIIPPAYTLSRSVEVLLSIGETIHVVDAQESEDRFLDIGPFTHISVSPNGRFVAIYTGTGKAYVITSDFQNRLSEHSSRSQITPKDLQWCGNDAVVIAWEDEVHIIGPSNAAARYFYDGRVHLIADHDGVRLITNNVCDFLQKVPEVTDEVFRFGTESPASILLDAVEQLEIQSPKADDNIQLIRPNLVEAVDTCVKAAGHEFSIHWQKQLLKAASFGKSVLDIYNSDDFVDMCETLRVLNAVRFYEIGLPISYDQYLRLTPEKLVRRLINRQEYLLAIRISTYLRLPTDRIYVHWASQKVRVGTEDEDTICRLIVDKLAGKRGISFEEIARAAYDEGRGRLATELLNHEPRAGKQVPLLLSMEEDEIALDKAIESGDSDLTLFVLLHLKKKLPLASFFRVINTRLVATALIESSAQADDAELLKDLYYQDDRRVDGANVFVREALKQPDSRTAMDKLALAAKLLSDSKDHALEVQVLKEATALLRMQEAFDRDLTESFTGLSVNDTMYKLIKLGYASRAKKIQSEFKVPEKTAWWIRLRALVSKRDWNELEEWSKTRRSPIGWEPFFTLILSAGNPKLASTFIPKAASTLATGMSIEMYEKCGMRVKAAEEAVKIKDVEALERLRSAAGVGSVEAREIQRIASAIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8F9</accession>
    <name>A0A3D8T8F9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Alcohol oxidase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_00603</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8F9"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF152">
        <property type="entry name" value="OXIDASE (CODA), PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04090)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="14"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase C-terminal" evidence="4">
        <location>
            <begin position="394"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="93"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW94840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="552" mass="60736" checksum="4E8F36D0E02D422E" modified="2019-01-16" version="1">MTTPVLSSSQVNDFDYVIVGGGTAGCVIASRLSEYLPDKKILMIEAGPSDFNDDRVLKLKEWLSLLGGDLDYDYGTTEQPNGNSHIRHSRARVLGGCSSHNTLISFRPFEYDMQIWESLGCRGWNFKTMMRLIDNLRNTVQPVHARHRNKLCKDWVQSCSTALDIPIIPDFNKEIKETGSLQQGVGFFSISYNPDDGRRSSASVAYIHPILRGEQKAPNLTILTHAWVSKLNLVSKTVKSVDITLKSGAKLTITPKTETILCAGAVDTCRLMLLSGIGPKQQLSDLSIPVVHDLPGVGENLVDHPESIIMWELNAPVPTETTMDSDAGIFLRREIKNAATSHSDPALNPKRIPDGTVADIMMHCYQIPFCLNTVRLGYEAPLNAFCMTPNIPRPRSRGRIYLTSSDPSVKPALDFRYFTDPEGYDAATIVAGLKAAREVAKQAPFRDWIKKEVAPGPKVQTDEELSEYGRRVAHTVYHPAGTTKMGAANDAMAVVDPELRVRGLKGIRIADAGVFPTMTSINPMLTVLAIGERAAEIIAAEAGWRGQIQPRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T8R8</accession>
    <name>A0A3D8T8R8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">LD-carboxypeptidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_00161</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase S66 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW94398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T8R8"/>
    <dbReference type="OrthoDB" id="5186469at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07062">
        <property type="entry name" value="Peptidase_S66_mccF_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10740">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.30.60">
        <property type="entry name" value="LD-carboxypeptidase A C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027461">
        <property type="entry name" value="Carboxypeptidase_A_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027478">
        <property type="entry name" value="LdcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040449">
        <property type="entry name" value="Peptidase_S66_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040921">
        <property type="entry name" value="Peptidase_S66C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003507">
        <property type="entry name" value="S66_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30237:SF4">
        <property type="entry name" value="LD-CARBOXYPEPTIDASE C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30237">
        <property type="entry name" value="MURAMOYLTETRAPEPTIDE CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02016">
        <property type="entry name" value="Peptidase_S66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17676">
        <property type="entry name" value="Peptidase_S66C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028757">
        <property type="entry name" value="LD-carboxypeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141986">
        <property type="entry name" value="LD-carboxypeptidase A C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LD-carboxypeptidase N-terminal" evidence="3">
        <location>
            <begin position="16"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="domain" description="LD-carboxypeptidase C-terminal" evidence="4">
        <location>
            <begin position="211"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF17676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW94398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="349" mass="38645" checksum="DE8DD261AEA454DC" modified="2019-01-16" version="1">MPDTIVPAALRKGDSIAFVSPSKRLNTSHPAALKRAKDFFEARGYKVKVIFDETKTEGLRATTLKRCEELHSAFRDPEVKAVLCTSGGHGADELLRHLDYELIRANPKIFAGYSDITQLIYAIFPNTGLRGFYAPAAITEFADLPAPPSFTVDHFFHVLANPTNEAVGPIPQSKEWFPDLAKFLVEDPSSEEPRVSRPNPGWKWLRPGKTTGRLHGGSFGVLYQFKGTKFCPSSHRGKTLMIETSMGASLREPLSFAQLRLQLSQLVNTGLFDEIAGLLVGRWYGYNDDERLEAEMLLLEFLEGTGFLILSNVDFGHTDPPLTIPFDALASLDSEKNEFVVLEAGVKGD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9D9</accession>
    <name>A0A3D8T9D9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_00897</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9D9"/>
    <dbReference type="OrthoDB" id="2559326at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031833">
        <property type="entry name" value="DUF4748"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41800">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41800:SF1">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15932">
        <property type="entry name" value="DUF4748"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW95134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="120" mass="13450" checksum="70017042F7D0502A" modified="2019-01-16" version="1">MNTVKSFWVGWASLCIAGGSSYYFAKKSINEDRKNRFEAARQRKQMQESLEYSNVHADTTAKESSEKNGGPLHAQLSPSQEVIDPAPTRHAPNTEGQRVAEKSKYEASEPYRAKKGDRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8T9Z5</accession>
    <name>A0A3D8T9Z5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Splicing factor 3b</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_01136</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000001">
        <property type="protein sequence ID" value="RDW95373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8T9Z5"/>
    <dbReference type="OrthoDB" id="10260794at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007180">
        <property type="entry name" value="DUF382"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006568">
        <property type="entry name" value="PSP_pro-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052584">
        <property type="entry name" value="U2_snRNP_Complex_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785">
        <property type="entry name" value="SPLICING FACTOR 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785:SF6">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04037">
        <property type="entry name" value="DUF382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04046">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00581">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP proline-rich" evidence="2">
        <location>
            <begin position="267"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="473"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="549"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW95373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="571" mass="64936" checksum="F4D139AECB621750" modified="2019-01-16" version="1">MAPKMTKNQMRRAKKKEQKKIQVDPTPEPEVEATPVTEPEPTKADEHAIEESPLEISEDDPNYAMYKEIMDRFGATTEEDEAAKDADAGDKGQVFYDDDDEIPDEDEEADKEPKLSKKKRKKRDQLSVAELKALVKKPETVDWTDTSASDPRLLVHIKSYRNVVPVPNHWSLKREYLSSKRGVEKAPFSLPKFIQETGIAEMRDAVLEKQDQASLKQKQRERVQPKMGKLDIDYQKLYEAFFRFQTKPELTRYGEVYYEGKEYETNLRHLRPGELSDELKEALNIPPGAPPPWLINQQRFGPPPSYPSLKIPGLNAPPPPGGAWGFHPGGYGKPPVDEFNRPLYGGDIFGVLQPQVNNQAGEPIERTLWGELQAPEEESEEEESDEEEEEGDEEDIGAGLETPSGMETPGGLASTAPSEYPGDATVGGDFDLRKTRRGTETEESTHPRSAYQVIPERQIRAEGFFGGERAYDVRSAQNANLPVLGQDEESRKRKKPGDVDVALDPDSLLNEDGISKDEVRRRFEQQKKEEQSAKGWQYDEDLSDMIAQESRKKQKRDEERRGEKRERSYRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q3I5</accession>
    <name>A0A3D8Q3I5_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_13200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000027">
        <property type="protein sequence ID" value="RDW56451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q3I5"/>
    <dbReference type="OrthoDB" id="10482334at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="85"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW56451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="158" mass="15816" checksum="21A6B99F57B09535" modified="2019-01-16" version="1">MAYQAIPAVTFTQPYSAAVTSPRLFIQHRQDSASDTSTSQPGPASTVTSRSGGGGGGILTRSGILTGSVLCGPDGQVCTINETATSQTGTSTTTGTASRATTSSRTSIGSRTTTGSATRTTTSGPATVTGNVGRREAGKGWKSLVLFAGLAVLVLDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q3X7</accession>
    <name>A0A3D8Q3X7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Metallo-beta-lactamase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_13166</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000027">
        <property type="protein sequence ID" value="RDW56417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q3X7"/>
    <dbReference type="OrthoDB" id="10250730at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07730">
        <property type="entry name" value="metallo-hydrolase-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051013">
        <property type="entry name" value="MBL_superfamily_lactonases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978:SF5">
        <property type="entry name" value="METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42978">
        <property type="entry name" value="QUORUM-QUENCHING LACTONASE YTNP-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="5">
        <location>
            <begin position="48"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW56417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="357" mass="39924" checksum="8AF96B39696E5F85" modified="2019-01-16" version="1">MASKPTFSVPSGETAQVSIIETGMRMDDITFSFLLAPPVDGFETISIPGWSFLIQSSKGQKVLFDLCFTPDKEIYPPGTWDFINAAGSVVHGNKHVTDILKNNNLDPAEINSVILSHHHWDHIGDVTTFPKTTEVVVGPGFKEHFLPGYPTDPSSYIEERHFEGRILREVEFSTSSLKIGKFRALDFFGDGSFYLLDAPGHDWGHLNGLVRTTSNPDTFIFLGGDVVHHGGELRPTKYLPIPDEVQFPLPDRVRARGVSTCPKGSQFRELNIKRGRKPDEPFFDPVLVVDMTDAVESIDKAQEADAQSNIFFLFAHDASIQGVVEFFPQSANAWKEKSWKEKHMWRFLGDITLATTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q543</accession>
    <name>A0A3D8Q543_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_12874</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000024">
        <property type="protein sequence ID" value="RDW56807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q543"/>
    <dbReference type="OrthoDB" id="5425374at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.10.10">
        <property type="entry name" value="HIV Type 1 Reverse Transcriptase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW56807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="267" mass="30903" checksum="AE3FA5A9658A0199" modified="2019-01-16" version="1">MQGPRAPGILPSHVTHWQDEQRLRQHFQDQLKYAIPGNAMNVIEILRSFVPDKSGSIFELTEQDEPDPKELLWIEKRYRKPENVEAHVRTLYKRRDKKVKPVDYSISDGTKPGGTRYWMDKVMKTEKQTETGPYDHWITPKFSGIARGSRLTPERIENLIIGTSITLQEREVLMELLYAREACIAFNFEEMGLLRPEVAPPQEIRTIPHVAWQTPGHPIPKALKSDAIAMIRERYKKGTIEPAYGPYRNPWFLVAKNKGGYRLINDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q6F5</accession>
    <name>A0A3D8Q6F5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ribonuclease H</fullName>
            <ecNumber evidence="3">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_12851</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000023">
        <property type="protein sequence ID" value="RDW57401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q6F5"/>
    <dbReference type="OrthoDB" id="5952526at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13934">
        <property type="entry name" value="RNase_H_Dikarya_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050092">
        <property type="entry name" value="RNase_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002156">
        <property type="entry name" value="RNaseH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10642:SF26">
        <property type="entry name" value="RIBONUCLEASE H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00075">
        <property type="entry name" value="RNase_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50879">
        <property type="entry name" value="RNASE_H_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="11">
        <location>
            <begin position="16"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="RNase H type-1" evidence="12">
        <location>
            <begin position="406"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW57401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="793" mass="88185" checksum="17FF391E30B99786" modified="2019-01-16" version="1">MSLNDAVPYDLAPQRCAVCADPVRLLHCSSCKVVSYCGTEHQSANRSKHKSACIAIRKSREVLEQEETALRADPGDGLIMPVDVFNTAVGHFWGILGTRDYMRARFAAVTALLRVHTVRAVEKALGHLTDMLRLCRSDNLGVRDIIPYLLLRLGREQECYDFLKWWAVVERDSYYDWGDTTLPYLDIRGADAFEPIDMFSSNRPRLPYIVALTLLKLRLYLDLTQFEDLEFGFGFNNSWAEPDQPVGMLVREKIQSLDLSDVSTVVEALRSQYQRLCQVVNDANPHFWEALVDEGDETPSPPPHYSPGSIEEANLALHICKRAWQETEDAILMVHSDTWRFTRVYEGNGIRNDPAETAEAMEIRRGTGHIIPSKFEPPSPTSYPSELFHSTSAGHNQMIRFVCCSNPKKVLVYVDGACADNGQPEARAGWAVVCGPPNSHEESSSWVACGRLEIKGPFGDVSAVTSNRAELRAVIAALRLCDWLEEGFDSIVIAIDSSYVVDGATGWVRGWVRNGWKTRTGDPVKNQDLWECLLGEVERWKACGLRVELWKIPRELNDDADTAAKRVIHEAADEAEFRDIVTRPLQTTTARTEVADCRVLALCLEEDSLVNAVHGNLISLIASKATMERATTQRATLSMLHQQPPPSIILILDGALTRQRRVWEHVIDHLRHGATVVLAGCFSSLVSPGQLNGFFAKLGLPWEMASYNRTKVNLRSNAVGGHLTNRLPPTYSPKAVFVKNVERSAAWYTSSDNSSETAAAFTKVGNGKLGYIGDVNGEQSSEVVVLAMCGLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q760</accession>
    <name>A0A3D8Q760_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12454</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q760"/>
    <dbReference type="OrthoDB" id="10443874at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="29"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW57653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="209" mass="22963" checksum="5E193C8C80AF2287" modified="2019-01-16" version="1">MLKRKRADSGLLSAAGRSQEVDASQEASEEPRASPPRRDISVRLASHRREDIPEYVVNNPVEFGRSTCWRCASEYKTFPDLKCWIHESSVKCGDCFKKGKSSAHGVVANESPANVATLAAAQKAFASRSSVVRKELADKSKALKENPWPTVLEALDKLGERIVNELQANNQQLTRCLQTSTEQIIAAINQAKEDGKQPKGKNSRDNASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8Q7V4</accession>
    <name>A0A3D8Q7V4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NmrA-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_12509</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000022">
        <property type="protein sequence ID" value="RDW57708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8Q7V4"/>
    <dbReference type="OrthoDB" id="3358371at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF26">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="3">
        <location>
            <begin position="1"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW57708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="343" mass="38421" checksum="6A8DECEF8409B1F1" modified="2019-01-16" version="1">MSKLLVVIGITGTQGGSVADAFLAAQNWRVRGVTRDPSKPAAREWASRGVEIVSADMDDVESLVNAFANAQAIFAMTDYWYPIRDPAVRAKATERGISADQLCAELETQRGKNMALAAASPAVQRTLERYVWSSLGDVSWLSGGKFTHVWHFDSKAAVEQYIREDPEIGKAGLTAKASFIHVGLYTDNWRRSGAEIQKDPVTGGYWHVTFDDGRTTLPFVWARRDTGPLVQKLVEDVEPGTRLLAVSQFAHYREFMAVWAKTLGQKLAGEDGIKRISEQEYRNMLPPIEDIRDHLMSTWLFFVNFGYDGGDPKIIYPKDIGAEHLMTSLEEYIKQEDWSSLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QAI2</accession>
    <name>A0A3D8QAI2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Heterokaryon incompatibility domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_12404</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000021">
        <property type="protein sequence ID" value="RDW58474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QAI2"/>
    <dbReference type="OrthoDB" id="5398779at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR39596:SF2">
        <property type="entry name" value="HET DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_1G17550)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="784"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="820"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="886"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="915"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW58474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="981" mass="111441" checksum="8DB6435727B9490A" modified="2019-01-16" version="1">MDHLSYPKKSHLPELYIPYLDPGEDAYDYGGFRTFPCRRGWEGEADCRESWVDAATDVVATRAQQWLYFGLLYEVFPPGATAMRSQDVFIEEYRDGEQDKRRLNSWSLPEKLECLQTANSELEAHISKELLPSLIFTRHQVKLLHDLNMPGESSLSLVILSITLLLEFIEHSGAVQYHYQQYATALRLPQPTCLIERFLQSGRCPSLALTMSARCTTSAFYFISSIEHMSSTENMPSISHGRCNESECVANTVDGSKVVHAERCDGKCKRIGPDLDQLSSILKKGSTPVLYFDHNANQHPGSRPILLGSAEADMDYVCLSHIWSQGLGSIDNKLPHCQVERVFKAVSKIPVTSSSTLSPNNSKVKQTQQDLLTSRTSATISPRLTHAYIVQGFGLIRYAFRRIPRRDRDMYKVYTLILTSEWSTRCWTLQEAALARKLYFLFADEIFNAFEPYFSHQVSRHTHPAHYLAPNPIRDSIYEWWGSLPSIMKADDGYRFAASPEQNFVSTWTGIGERHTSKPEDVHIILSIMTDMNVGEITPLNSDDRLKATLRAQRYLPLEMLAYQVSRKNGAFKRMHEGGSSEEDALVDKESCLKEWQPPFPSGCNIQDSQFFARLHGGILQYDVGSIRCNIGNSKFSHLLILTFNQEFPWSEKLPIFIKPNTCWLITQDLPDGVPMTSNACLVIFRGAWSSIQSGRGFRCVMVKETSRRVKLRYVCPIIYSTAHKVNRSANTTQPLVATTHPRHTNIELDCGMHDWPLSTQRRTRQIGIKLIELLYGRSSVSHICMMFCFMVGPAVIWTAFLWIGSNRWGQMPPGVNYVVVYYFLIGVVGRGLGFFMFESLLFISPRCARDKYMALVQSFKANETRPTRFSRLGAHVSTFINLCTLWGRLTTSIVLGTALVFLLLGTIMKFDKTGLLVSIGAAIFIEYGARLAFVCCFHFLLLMRDGYLENWTRERRTGIGTIDERKGGYESNEPMPRILI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QCD3</accession>
    <name>A0A3D8QCD3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DUF1772-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_12038</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the anthrone oxygenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000020">
        <property type="protein sequence ID" value="RDW59114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QCD3"/>
    <dbReference type="OrthoDB" id="5954308at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013901">
        <property type="entry name" value="Anthrone_oxy"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042">
        <property type="entry name" value="ANTHRONE OXYGENASE ENCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35042:SF1">
        <property type="entry name" value="DUF1772-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08592">
        <property type="entry name" value="Anthrone_oxy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="95"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW59114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="18503" checksum="6C1C0F22409CB00B" modified="2019-01-16" version="1">MATSQITLQIARAVGIAGAAWLSGNIAALSLISVPALNTSHAQDSVSLSTITHAWKHTYAKGKSQNPPVAAVVATSFAYLAWASHRLRAGRSMQLYSIAALLTIGIVPYTILTMSSTNNKLLAKSKKASSDAEITRAVSPAEDKETSDLLKKWTFLNGIRSTMPLLGAAAAALAALA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QE85</accession>
    <name>A0A3D8QE85_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nitrogen regulatory protein areA GATA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_11741</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QE85"/>
    <dbReference type="OrthoDB" id="5563539at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042149">
        <property type="term" value="P:cellular response to glucose starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007039">
        <property type="term" value="P:protein catabolic process in the vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013860">
        <property type="entry name" value="AreA_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052292">
        <property type="entry name" value="Glucose_repression_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28051:SF1">
        <property type="entry name" value="PROTEIN MTL1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08550">
        <property type="entry name" value="GATA_AreA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nitrogen regulatory protein areA GATA-like" evidence="2">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="30"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="517"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW60135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="583" mass="64251" checksum="30D8DA6AB066EA97" modified="2019-01-16" version="1">MAVVLSAEENSYFSSSSLRRSHSQPKFGTPHSAYSSPLSKSKSSHSFNTIISPPTSANSSAPSSPRTLHADSAAQSYASTPASSLSLDAHCEDVEDEDQIVFPSYDDVGYYGQVEELESPASPRTGDSYTVSPTSNSTSTNVSRPGSPDLAEHAEDDTAIRTQPSRHVDYLSHNWKEEDIWSSWKHIVSKRKAYNNSARLENASWRTWIKSKYKLKTVSPETLNWLKDCDVTWLYGPLQTGTDRTLHIPSTSPASSSRISKSNSFLNKKPILKKRSMSEIMLQRSLSASSLLKQAAAAVQAQQDAGEGDFGRPGIIRATSDYVAFPFSTRRVSRENTSVLSSITSSGLATPGTGERKHIHFNEQVEQCIALEMKGDDDEQDSYAVQDFDSDSDDGGIMMKRSNSHRKIPPIASKKSTPRASFCAESKTIAMLPSTTLKYREDTPEPQETAMKHSNGYWNGTKLSPSPSQETLRPSKPSSRMLLGDDDEDDDADMDWQPPSAFANRKDSMAVTQERFQSLQSQGSSSSLTGEPSGMRRTPSGMFMPYEEDEDDVVSEGLFGKVVDTVNTAKDIAHVIWNVGWRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QEF1</accession>
    <name>A0A3D8QEF1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_11687</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000019">
        <property type="protein sequence ID" value="RDW60081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QEF1"/>
    <dbReference type="OrthoDB" id="10474822at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW60081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="106" mass="11884" checksum="1E5D7916DA07E9DC" modified="2019-01-16" version="1">MATIRLARNSMSPKPKSRGSRRSTMSTTSQQSSPPEPSFHIHRKSTASTSSSKSSTSTRRREKREPGGAHGESAADKVERCLWYARNLAIVYGHGFRHGFMLKRHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QIM0</accession>
    <name>A0A3D8QIM0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_11453</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QIM0"/>
    <dbReference type="OrthoDB" id="4815532at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017748544" description="Secreted protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW61561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="140" mass="14880" checksum="01B087B9E3E37533" modified="2019-01-16" version="1">MLFNNLAGSALAICALLVPSVLGQDNLEPRTLDMEVRWFPTTNCHSGGGPPRGYSRNVCIPISTTSHGIKILESLGSCRSKNSLIVSLVMLVGLSLKTPADKIRVLVLAYDSGTCTGKAKIFDTAGCNSLAKKWSVKVVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QIN7</accession>
    <name>A0A3D8QIN7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Enoyl reductase (ER) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_11574</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QIN7"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42940:SF7">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE-LIKE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="11"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW61682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="334" mass="36234" checksum="3EC5F04EAD2050C9" modified="2019-01-16" version="1">MTDFIQTTYRGVEGSPKSAQSKVPELGPLDVLVKITHSSLCGTDLAYIPYGIALGHEGIGVIEKVGSAVTRLNIGDRVGGGYHRGSCGYCRYCLSGQDIWCYERVIFGEGDYDNGTFSEFYIGRETYVHKIPDEIPSEFAAPLQCAGATVYGAMIGVVKPSHKVGILGIGGLGHLAIQFASKLGASVVAFSHGTSKEAEARSFGAEEFYSFDDIAKMSVPVDVLVLTGNKYPDWSRFLVKTVLARTGTVIPLSEPSGAMNLPASKMFFEGYNIHSNLVASRGVHDDMLKFAAHHKIRPVIEKFRLSEDGLDKAVEKLKAGSVRYRAVLVREENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QIW2</accession>
    <name>A0A3D8QIW2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">adenine deaminase</fullName>
            <ecNumber evidence="2">3.5.4.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_11266</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>adenine + H2O + H(+) = hypoxanthine + NH4(+)</text>
            <dbReference type="Rhea" id="RHEA:23688"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
            <dbReference type="ChEBI" id="CHEBI:17368"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="EC" id="3.5.4.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.2" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000018">
        <property type="protein sequence ID" value="RDW61374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QIW2"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000034">
        <property type="term" value="F:adenine deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006146">
        <property type="term" value="P:adenine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.40.10">
        <property type="entry name" value="Urease, subunit C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01518">
        <property type="entry name" value="Adenine_deamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006679">
        <property type="entry name" value="Adenine_deam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026912">
        <property type="entry name" value="Adenine_deam_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011059">
        <property type="entry name" value="Metal-dep_hydrolase_composite"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113:SF2">
        <property type="entry name" value="ADENINE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11113">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-6-PHOSPHATE DEACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13382">
        <property type="entry name" value="Adenine_deam_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01979">
        <property type="entry name" value="Amidohydro_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51338">
        <property type="entry name" value="Composite domain of metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="6">
        <location>
            <begin position="90"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="domain" description="Adenine deaminase C-terminal" evidence="7">
        <location>
            <begin position="442"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW61374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="645" mass="69217" checksum="50546BD67A887B41" modified="2019-01-16" version="1">MAGTTPPIHPSNSTGAHLTITVDELMNLRLVALGTRSPSLIIRGGHILALHTGEILPRDVVVAGRHIAAITPWNHFPTDAVLEVDARGKFISPGFIDAHIHIEYTKLVPGELARLSVPRGTTTVLADANCIANVFGGKGMDFMGETSTPLRIFRQVSHKIPGNPPELELGGVTMTAAELCERVSRSEAATLGESNPFSLDLASAQKQAAALHAGKRITGHTALLENEPLWAYAAGGIGDDHNAHQPEDVIERLRLGMMLTVMSGSMNSNIASVFSDIPALKDGLGHISFCADDKLAEDLDGEGHIDYHVRQAIKLGVDTVKAYRMATLNPATYYRLDHLIGSVTPAKLADLLILDSLEDVRPTAVVMNGKLVAKDGKALFENTDEVPEFTLNSIHIDPSFLEPSTYHVFPGEGRTEAWVQAMEMYDGYFKRAFHTKLFSSSENAPLQCDLKRDVLKVVVIDRHHATKNLGIGFVRGFGLRRGAIACTTNCENQNLVVIGTSDEEIAHAVQSIMKVGGGFVAVLEGDTIGSVKLDVAGCMSSDPWEKVRDESLALDAAVKGLLGCTTKAPFMIASFVGLVGVPDLGLTEKGLIDCKTQSLMNVVLSEDQGLIESVSVGGAVKICCRCPSHAHDVHRMMDSNTAVII</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLF1</accession>
    <name>A0A3D8QLF1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_10840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLF1"/>
    <dbReference type="OrthoDB" id="2441642at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23502:SF51">
        <property type="entry name" value="QUINIDINE RESISTANCE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="134"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="46"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW62538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="277" mass="29787" checksum="D12266D6F5A28BF2" modified="2019-01-16" version="1">MPDSYTEKITPRGPGQEAFTSSTYANTHAKTEQNNDAALAITQGTNTQNLLVDEQQNGENAGNIKPEHKIDDKPYSVFTHNEKKIIVLCAGLSQFFSPISGQIYFPSLDAISDLFGIAPAFVGGFSVDSGRRPTYLICFVIYVAANIGLALQNNYAALMVLRCLQSAGGSGTVALASAVVSDIVTSQERGVYVSYMSVVPQAGPSLGPIIGGLLGQYLGWHSVFWFLLICTGVVAIPVALFFPETCRKVVDDGSVPPPRWSRSYLNTNVEKRLIAEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLN7</accession>
    <name>A0A3D8QLN7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Amidohydrolase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_11038</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLN7"/>
    <dbReference type="OrthoDB" id="2135488at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006680">
        <property type="entry name" value="Amidohydro-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052350">
        <property type="entry name" value="Metallo-dep_Lactonases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43569">
        <property type="entry name" value="AMIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43569:SF2">
        <property type="entry name" value="AMIDOHYDROLASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04909">
        <property type="entry name" value="Amidohydro_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amidohydrolase-related" evidence="2">
        <location>
            <begin position="122"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW62736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="345" mass="38206" checksum="D1113F4872B50F2C" modified="2019-01-16" version="1">MAAEYPIVDSHIHLYPAGELETLAWVTPDNPLNKQHSLEEYTAATGAPSALEGFIFLETDRKSTVEPGDDGKGWAMPLMEVDWLRRIATGQPKEGEGHTAADSKLCLAIIPWAPVPGGAAAMEQYVGGVKKHAGESFGKIKGFRYLVQDKPKGVMLQDGFIDGLKWLGRHGYVFDLGVDQHSGGKWQLEEAVEMISRAHEGVPEEEKVAFIINHLCKPDLSIYNPTDPSFVAWRTAMYTLSSCSKTYMKLSGCFEEMPAGLKSAPVPEIFEGMQNHLAIILAAFGAFRIMYGSNWPVCTVGVEDSWTKWREVVQRFCYLGGLTPEEQIMIWSGTAIKAYNIKELM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QLY8</accession>
    <name>A0A3D8QLY8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal protein L22e</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_11145</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QLY8"/>
    <dbReference type="OrthoDB" id="10259820at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.210:FF:000001">
        <property type="entry name" value="60S ribosomal protein L22 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002671">
        <property type="entry name" value="Ribosomal_eL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038526">
        <property type="entry name" value="Ribosomal_eL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064:SF31">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL22A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01776">
        <property type="entry name" value="Ribosomal_L22e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW62843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="126" mass="14232" checksum="C62A37C60E08AF48" modified="2019-01-16" version="1">MAPATKTSAKGKQAKVTKKFIINASQPASDKIFDVSAFEKFLQDKIKVDGRVGNLGETVQISQQGDGKIEVVAHTQFSGRYLKYLTKKFLKKQQLRDWLRVVSTSKGVYELRFFNVVNDEAEDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QMB9</accession>
    <name>A0A3D8QMB9_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_11092</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000017">
        <property type="protein sequence ID" value="RDW62790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QMB9"/>
    <dbReference type="OrthoDB" id="3248909at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021840">
        <property type="entry name" value="DUF3433"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544:SF3">
        <property type="entry name" value="SPRAY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37544">
        <property type="entry name" value="SPRAY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11915">
        <property type="entry name" value="DUF3433"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="357"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="398"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="516"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="624"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="660"/>
            <end position="678"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="723"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="782"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="13"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="606"/>
            <end position="616"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW62790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="902" mass="99551" checksum="4CA76985831C9B46" modified="2019-01-16" version="1">MAGDGARDGYPWMSSQRGIESPSANRYSTVSALSSPGTPDMGFTSHRSSTVSLPTPEERPQEVVDVSHVRLPSEGGSGVTSPSYDSSTQTRISLPESLRAGTPASPTSRTFNPFARIANTAYEPISAARRPSLSKPGARRFSTKKKVGIITDSSIPEEEIDMGLLQYAAPFSSRGTAYKPLGGTEDDDFHVTSPVAAGFDISSFAGPLTPHSEAQLQELHLQEAQGILTGGLGAGFKPGATLKSAELFATADPAAAGTVSRTLSRRISQRVSSHSARLQRTATIRDLGQNEANKRGEIIEVIMEDAPVDLSTYEGGNASTTDFEMLDDASKRKSTMRSRNVEVFYPQANWRPFSMRWPYLAALIMLSVVLASAQEYVYQKSMIKPLYEFNRPSDLKTWDYFCFKYLPTLIAVAFGVLWQITDFEVKRLEAYYQLSKSGGALAAESINVDYITFFDFLRPIRALRCKHHAVVVSSCATLLAVSLVPTLQSSSVVLSPNRLAREADPDGLKNIRMSGVFSRLLSVVLLLVALLGCVLLWQLQRRRSGLVADVKGIAGIAAMANRSHILMDFKDMDTATPEMIYHKLKDHRYTLQNSSLAPDDQVPLTRQEKDRYDQQQRKTNPHPFMLRLPVGIMVILGMLLFMGLIPVVLFTNANIITDKAPWFVTGLAVCIKLAWGSIETDVRMMEPFYLLSKRHAAPKVLTLDYSSMPFAWMPLCAFLNGHLLMGLVGLGSVLAEVLTVCAISFSGVAGRDFTSSPGPHVNYTKANSDLAHNASEETLLSFWLSFGLAYFILAFLSLVAIFVYARRRHTFLPRQPNTIASILAYIHQSKMLYDFVGTEKMNNDEMVTHLEQIGKKYGVGWFTGRDGEVHCGVDEEELVSGYKHGDDARKASMPWSTDWEHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="23" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQ79</accession>
    <name>A0A3D8QQ79_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">White collar 1 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BP5796_10457</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW63955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQ79"/>
    <dbReference type="OrthoDB" id="447251at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009881">
        <property type="term" value="F:photoreceptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00130">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00202">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000064">
        <property type="entry name" value="Vivid PAS protein VVD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.20:FF:000063">
        <property type="entry name" value="White collar 1 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.20">
        <property type="entry name" value="PAS domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001610">
        <property type="entry name" value="PAC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000014">
        <property type="entry name" value="PAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035965">
        <property type="entry name" value="PAS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013655">
        <property type="entry name" value="PAS_fold_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00229">
        <property type="entry name" value="sensory_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429:SF7">
        <property type="entry name" value="GATA-FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47429">
        <property type="entry name" value="PROTEIN TWIN LOV 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00320">
        <property type="entry name" value="GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08447">
        <property type="entry name" value="PAS_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13426">
        <property type="entry name" value="PAS_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00086">
        <property type="entry name" value="PAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00091">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55785">
        <property type="entry name" value="PYP-like sensor domain (PAS domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00344">
        <property type="entry name" value="GATA_ZN_FINGER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50114">
        <property type="entry name" value="GATA_ZN_FINGER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50112">
        <property type="entry name" value="PAS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0010">Activator</keyword>
    <keyword evidence="9" id="KW-0157">Chromophore</keyword>
    <keyword evidence="11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0600">Photoreceptor protein</keyword>
    <keyword evidence="14" id="KW-0675">Receptor</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0716">Sensory transduction</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PAS" evidence="17">
        <location>
            <begin position="377"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="17">
        <location>
            <begin position="552"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="domain" description="PAS" evidence="17">
        <location>
            <begin position="682"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="domain" description="GATA-type" evidence="18">
        <location>
            <begin position="892"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="18"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="72"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="275"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="926"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="275"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="928"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="958"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="968"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="998"/>
            <end position="1014"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RDW63955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="21">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1014" mass="110782" checksum="218E63203E10F695" modified="2019-01-16" version="1">MNQFFGTQYSQEDLQQRLAQRRSRNGTARAMSLAMGSSGPPGPQRNDDTMDMNRMVGGDSLDDIIMQNNTELQRRQSYPRPYGDEMSTDDARNSSMMEFGSSSNNGLGGFQFGTPAAAAGDVSLRRPSVGEMDMSGNYTMMHSEINMPGQMGYTTSIQPQEPLAIDTSSFSNMSPEMISNMMNYVPMGMDAAMSDGEPTPIRTIFSGNNFSPFGDSGVDVMQNNFMMSQDGLSNDQNTYSEDPDNDNEVLPTASNLNITDGHLVSSPINTSMNQSVSYPSPVQGSLTATSFPHQESYNMPVSTGPSTSTPDVISKTKGLNRHESSSNFQNVYSSSGFDMLKALMRVASRKDPEINIGAVDMSCAFVVCDLKQNDCPIVYVSDIFERLTGYNKHEVLGRNCRFLQSPHGKVQAGVKRTYVDDDSVYYLKDKISRKAEAQRSLINYRKGGQPFMNLLTMIPIPWDTDEIHYYVGFQVDLVEQPGSVAGKSAGGSYTVNYSQGRLPRYVWQPPEGARPQADAGQTISRDDVSAVLSSFNNSGESELTKRMWDKVLLENTDDVVHVLSLKGLFLYLSPSSRKILEYDSSELVGTALSSICHPSDIVPVTRELKDSSTGAAVSVVFRIRRKNSGYTWFESHGALCVEQGKGRKCIILVGRERPVYTLSRLDIEAVGGIGENELWTKLSTSGMFLFVSANVRTLIDRQSDELVGTSIQAIMRPESKLEFGRSLEKARTGKRVIFKHEVLNKRGLVLQAQTVLYPGDATEGSKPTFLVAQTRFLKSASRSAPSNLIQYSSASSTTSLLQRDFGEMPSPRSSVGIVTEAGGGGLPIGTQDLALASDDNIFDELKTTRCTSWQFELRQMEKSNRLLAEELAGLISNKKKRKRRKGAGHLQRDCANCHTRTTPEWRRGPSGQRDLCNSCGLRYAKQTGRVSPRSSTRGGDAASKKSGSPPHKSPLRNKVSQSTTPSTSNVNPASSSEGSSGNTGLTSTSVIPGILSKPSLTDSQLTASTGDNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQN1</accession>
    <name>A0A3D8QQN1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="6">F1F0 ATP synthase assembly protein-like protein Atp11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_10625</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQN1"/>
    <dbReference type="OrthoDB" id="16535at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033615">
        <property type="term" value="P:mitochondrial proton-transporting ATP synthase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010591">
        <property type="entry name" value="ATP11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126:SF0">
        <property type="entry name" value="ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13126">
        <property type="entry name" value="CHAPERONE ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06644">
        <property type="entry name" value="ATP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0809">Transit peptide</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="82"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="93"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW64123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="308" mass="34997" checksum="F88DE56C349A35A5" modified="2019-01-16" version="1">MASFRSPAIRNLISGAAPYLRASQRRWAQVHDVRFLATQQPDRILERYKEKLARKAKEEGLRDVNELKEVYKEKIESLKKKATVEIPTADTLPTPPPSPQNASPFPPPPPPPTIPSEKPAGTPGMKTLSSYLDLEKVRELPPKEIEGLWRLRHVKSAQSLCASIPLPVYRTIESTAKKFPQFILPLPRENKPTEIHFLQWTFPAPDTVVVLFTHLAEYKVRGEYAEPHTTVTHHLELANEKELVLMKGDVMEGKGVSVTEAQWLILCLQRFYGEQGQEAARRNLLEGFKKGDERFNVEELVQEAEKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QQW7</accession>
    <name>A0A3D8QQW7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_10718</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000016">
        <property type="protein sequence ID" value="RDW64216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QQW7"/>
    <dbReference type="OrthoDB" id="20105at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019240">
        <property type="entry name" value="DUF2196"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03833">
        <property type="entry name" value="YwbE family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40069">
        <property type="entry name" value="YWBE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40069:SF1">
        <property type="entry name" value="YWBE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09962">
        <property type="entry name" value="DUF2196"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW64216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="186" mass="19817" checksum="F6112A8F0737333E" modified="2019-01-16" version="1">MGVPKMSQLRSGISVNIVLKADQPTGKLTSGCIADILTRSDHPRGIKVRLQDGKIGRVQSLSSSTAVLGGSSSSNPTSPDSSRASLPGRQVGGSMRSGSGHFKMQDDYRNDPVPSESLSLEDYIKPAKQKRKRKNNAATAEPPESQEQNQALLESEFPNIDSALVAAMLLEYPTLAEARGVLQALS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QU50</accession>
    <name>A0A3D8QU50_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Fe2OG dioxygenase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_09997</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QU50"/>
    <dbReference type="OrthoDB" id="420380at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.620:FF:000027">
        <property type="entry name" value="Oxidoreductase, 2OG-Fe(II) oxygenase family family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF246">
        <property type="entry name" value="TRANSMEMBRANE PROLYL 4-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="6">
        <location>
            <begin position="144"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW65305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="285" mass="32315" checksum="B6EFBFFC16D714B7" modified="2019-01-16" version="1">MIGYFLALIPLYIVLYQPITNLIYGTPALQIQINPEIFLNTSFIAVEDATSRALDCPAHTYQTHILKLEPLIIYIEDFLTVSEQEHLIKISADKFEPSTVTTGQETSVNEEIRRSEVAFLDRDNVVRCIENRARAFQGWRENLHIERLRTQRYGPGGHYAHHYDWSGGSRAQDRVSTFMVYVDVSEDIQGGGTEFPHLRMKIGKESGMKRWCEFLDCEKMTEGSGTGEGEGGGLVFRPVKRNAVFWVNTQPDGRGYEETWHAGLPVEKGEKVGLNIWSWGSARGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QUJ4</accession>
    <name>A0A3D8QUJ4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alkaline phosphatase-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_10050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000015">
        <property type="protein sequence ID" value="RDW65358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QUJ4"/>
    <dbReference type="OrthoDB" id="2118639at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002591">
        <property type="entry name" value="Phosphodiest/P_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01663">
        <property type="entry name" value="Phosphodiest"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW65358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="394" mass="42899" checksum="57C26C3FBE34C48C" modified="2019-01-16" version="1">MTSDSQKLYKYVATFSVDGLHSSDIGKYTAQRPNSAIAQLLETGHQYTDAYTSGPSDSFPGTMNLYTGGSPRTTGIWYDDTYDRTYYLPYSTTGTSCSGPSGAEVAYDESKDYNSTELFSGGLDPQNLPQTIINGKCVNVYPHQRLRVNTVFEVVHAAGLQTAYTDKHPSYDVVRGPSGRGLSVGYFPEIAAIPVTVNDTIAYDELHVKAFLEWINDKTPAHSEIQDGLKVTPSVFGGNFQAVSVAQKTKGYVPGSLDFTPDLLQALDFVDASFANPEIIAPAAGVNLSFVTTDDIALIFLENHADVNTAVDNLNGKRDELHIQDIISHERLTYLGYGDPLRDPAVPDIIIRPELGVIYTGSTAKIAEHGGLSDDDRKIACFINNPGQEDYLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QYE3</accession>
    <name>A0A3D8QYE3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Glycosyltransferase family 32 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_09565</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Endomembrane system</location>
            <topology evidence="10">Single-pass type II membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW66816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QYE3"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000136">
        <property type="term" value="C:mannan polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.20:FF:000002">
        <property type="entry name" value="Initiation-specific alpha-1,6-mannosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007577">
        <property type="entry name" value="GlycoTrfase_DXD_sugar-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039367">
        <property type="entry name" value="Och1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31834:SF1">
        <property type="entry name" value="INITIATION-SPECIFIC ALPHA-1,6-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04488">
        <property type="entry name" value="Gly_transf_sug"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017763601" evidence="12">
        <location>
            <begin position="28"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="42"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00060399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW66816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="371" mass="41612" checksum="F76A85BD51426532" modified="2019-01-16" version="1">MLTFRRAIIAAAFFLTTIFLLSRSHSAAPVRVTADDLAKDVHASSGSSEGVTKSPSNVIPPANSGKKPATQQPLQDMSKAPLREKLAYQFPYDVETKFPAYIWQTWKYTPSSGEFGEKFRPAEASWSEKHPGFVHEVITDQVAVHLLRHLYASVPEVLEAYTALPVPVLKADFFRYLILLARGGIYSDIDTHALKSAAEWIPDKVPRSSIGLVVGIEADPDRPDWAEWYSRRIQFCQWTIQSKAGHPVLRDIVARITEETLSRKKNGTLKAKDKSIVEFTGPAIWTDTIFSFFNDERYFDMTTSKGNITWRDFTAIKTAKKVGDVVVLPITSFSPGVQQMGAGDYDDPMAFVKHEFEGTWKPEKERHVGGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8QZ62</accession>
    <name>A0A3D8QZ62_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">D-malate dehydrogenase (decarboxylating)</fullName>
            <ecNumber evidence="4">1.1.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">BP5796_09818</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12 13">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>(R)-malate + NAD(+) = pyruvate + CO2 + NADH</text>
            <dbReference type="Rhea" id="RHEA:18365"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15588"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.83"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the isocitrate and isopropylmalate dehydrogenases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.83" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000014">
        <property type="protein sequence ID" value="RDW67069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8QZ62"/>
    <dbReference type="OrthoDB" id="10261637at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046553">
        <property type="term" value="F:D-malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.718.10">
        <property type="entry name" value="Isopropylmalate Dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050501">
        <property type="entry name" value="ICDH/IPMDH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019818">
        <property type="entry name" value="IsoCit/isopropylmalate_DH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024084">
        <property type="entry name" value="IsoPropMal-DH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011829">
        <property type="entry name" value="TTC_DH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02089">
        <property type="entry name" value="TTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43275">
        <property type="entry name" value="D-MALATE DEHYDROGENASE [DECARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43275:SF1">
        <property type="entry name" value="D-MALATE DEHYDROGENASE [DECARBOXYLATING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00180">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01329">
        <property type="entry name" value="Iso_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53659">
        <property type="entry name" value="Isocitrate/Isopropylmalate dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00470">
        <property type="entry name" value="IDH_IMDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Isopropylmalate dehydrogenase-like" evidence="11">
        <location>
            <begin position="13"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="RDW67069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="366" mass="39775" checksum="32C6C0CE9EACD6F1" modified="2019-01-16" version="1">MSPSIVNAHPTYKIASIPADGIGPEVIDAGVAVLKKLASTLRTFDLEFENFDWSSDRYKQTGKYLPDDALATLKKFDAILFGAVGAPNVPDHISLWGLRLAICQPLQQYANVRPTKVFRGTKSPLANCKQGDLDWVIIRENSEGEYAGHGGRSHQGKPWETATEVSIFTKHGVERIMRFAFETAAKRPRKQITVVTKSNAQRNGMVLWDEVAAAVAKDFPEVTCDKMLVDAMTTRMVLKPESLDTIVATNLHADILSDLAAALAGSIGIAPTSNLDPTRENPSMFEPIHGSAFDITGMGIANPIATFWTAVEMLKWLGEDKAGDLLLDIVETVCEKGIMTKDLGGTSTTAQVTDAVCAEIERRSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R2R3</accession>
    <name>A0A3D8R2R3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">HMA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_08897</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R2R3"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000002">
        <property type="entry name" value="Copper-transporting ATPase 1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056236">
        <property type="entry name" value="HMA_PCA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027256">
        <property type="entry name" value="P-typ_ATPase_IB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01511">
        <property type="entry name" value="ATPase-IB1_Cu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01525">
        <property type="entry name" value="ATPase-IB_hvy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46594">
        <property type="entry name" value="P-TYPE CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46594:SF4">
        <property type="entry name" value="P-TYPE CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24534">
        <property type="entry name" value="HMA_PCA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00702">
        <property type="entry name" value="Hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="464"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="496"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="681"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="719"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1025"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1054"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="9">
        <location>
            <begin position="282"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW68240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1082" mass="114494" checksum="6AF821FB3173F86D" modified="2019-01-16" version="1">MSPSCCKGKQVHPTKTGVAAGLEPGAEYPVESPVSKPGDKDACCDGDNVEPVAQTGSQKLVKLEKMANSCTECIDAPKPEQPCCDESCMVRIAVRECEDSCGSDKTCATASSGCKDLESKDDCCTKAPEAARIKKTPCQSHMQSVKSRFQPTLEGLGCICRALLALNLESCCVTGQNAQRKSRQPGARTYDPCSSSSTSLKSAKDDGCCSMAPPGSCKKPAEPRLSITSCAKICCSEKSKPPAIGTPDDCCSGGSCSKEKANLGATASEIGSDLEQGAINAEHVVLSIQGMTCTGCETKLERSLANIRGVSKIKTSLILSRAEFDVNIAHISVDGAVTRLQKATGFECQRLSTDGHELEVLLPDALETVLQHLPSGVLSIDPTTYATLKITYDPQLIGARDIVESAFDQQLELAPYRPDPSISAGNKHVWQMGLAALISACLTVPVLVLAWAPLPKREITNGSISLALATVVQIFIAGPFYPAALKSLIFARVIEMDLLIVLSTSAAYIFSIVAFAMLVARKPLSTGEFFETSTLLVTLIMLGRFITALARQKAIESISIRSLQQSTTMLVESDGTSTRDIDVRLLQYGDTFRVMPEAKVVTDGTVISGTSEINESMITGESNPVVKSKGSPVVAGSINGPGTLDIRLTRLCGDNTISTIANMVDEAKLSKPKTQELADRVAGYFVPVIVAITIVTFVIWVAVGITIQQRSSSDATVQAVTYAIAVLIISCPCAIGLAVPMVIVIAGGVAAEKGVIFKTADTIEAARNVTHVVFDKTGTLTIGRLNVKESYHVNGLATDVRPILLGLVSGIKHPVSQAITEHLQSLGVSPATVLNVKSLPGKGVLGNWNGSEIRAGNALWTQATPISKVQQFLTTDSTVLCFTINNTLQAIYALQDTLRPEAAHVVSTLQAKGISVSIVSGDETGAVQKTAERLGIPSSNALSRCSPTDKHTYIQMLKTSSTGSTILFLGDGTNDAIALASADIGIHMSEGTDVARSAADVVLTRANLRGVLVLMELSDKALRRIMFNFAWSFVYNLFAILLAAGAFVKFRVPPAFAGVGEIVSVLPVIIIAVGLRWARFSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R3G3</accession>
    <name>A0A3D8R3G3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_09108</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R3G3"/>
    <dbReference type="OrthoDB" id="3560327at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="448"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="671"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="847"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="302"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="679"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="713"/>
            <end position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW68451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="883" mass="96076" checksum="E8D9E143FB391FD4" modified="2019-01-16" version="1">MKVSKALQGAINEWRNGAAVLQVDGEDLPESDITETNNQIVANVQVSPGDIVSVAFYIQSGAVDIADLLVDGILRNSKINTRASKAFSDVFDRACYNPRKPERLARVGMKFCEMRVVNWSGNTGALATKSSESSPIGTVEIRFYRIDKQSSAAGPSNQDTEKQASTLSRGPNFVNYATWSELEGSIINNGSTPPFEIDFCNPSPGDTGLGPKKRVVTEYPATYKLWCSFVFRLRPKSGDSSATTLLSQHNPETKVVHEAWHDALAPPGSASTMSTSPVSSGAQTSLSTPVISEERYQDNPEKSGTMSRITNSSDASRNTVPAVSSSEKAQTQEVRIAASTAENIKDTARNIETTSPDTSVPLELSTPKKLPVAEEVVSSMINGHQNANDTISTTCSDAEVHNPTPGRIARELHEGLRISVENVLQGNATNDGLETDPHNIEQKLVRGTEVDDSSNVEDCSANKRPSQCPTGEAEVGRLKADSIESSDLQPTQREIAESVAGSSFEEPTFKRSSPPLKLAGIPGAPAFHAWQDRGSTREPSTPLATREPSVSSILRDREPTQEIGLSPMLGGILHFDRQQQLPTSRAFSTSLPTTPKPPLSREYHILENKTNASQNSLASTSGSKTPMVNSSLILGNSPPITYNQQSITPFYNPRPCSVPLNTGISSVVPISGGKDLDNEQQTSSTTSHKVIVDSQATTASYSSNEPAVEKRSSAQTYNGSTLSKGNGAAKRKVDEISTSEPLTVKEAFQLKREFSNTILEDTKRRKGKEKTQEHYGQYLPSLATTAVVKSPSDHEHESDEHYSFVKVAESATVITWEAEERKASNRYSIAIQSRNIAREQYENALLENKARVQIHELLRKAAELENETAELRNKTRALREEFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R3Y4</accession>
    <name>A0A3D8R3Y4_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_09325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000013">
        <property type="protein sequence ID" value="RDW68668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R3Y4"/>
    <dbReference type="OrthoDB" id="3431997at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW68668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="291" mass="33455" checksum="46F9780989C1AA92" modified="2019-01-16" version="1">MVELRDRIAAIQAALAEEQDVKFADPLARHSLDHRFDHTAPEVDAAPAPTPAGERTNPFESIQIPAPNADSKPQFYDSIAQKFGLGILDEDEFTEYVVYDASLTNLRVCPLDMADHGHYYYVDYRFSLPHVPGVVLREGSERTGKSLGAAHIPIQGENRLGVGDYDRTPHEMVWEKMGNTGFWTHMRYEFEHETADGKRRVFHWIRTRNNIMDDQGDLVLVEQGKEQLVLCEYLGKGLLKWKKRGRLRLRTMEGFGQSWEIIVLLSWASVVEMSRRRARYRRYSPTHLIGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7H9</accession>
    <name>A0A3D8R7H9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="6">PPIase</shortName>
            <ecNumber evidence="6">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_08396</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="6"/>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW69999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7H9"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000003">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD repeat-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0697">Rotamase</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="8">
        <location>
            <begin position="38"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="9"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW69999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="187" mass="20190" checksum="5EF47996BEBA9DB3" modified="2019-01-16" version="1">MGLFSKIFKSGDKESESSSAADPNIEEGPPATGVLMTTSLGDITIALYPDKAPKACKNFATLCDTHKFDNCPFHRIIPGFMIQGGDFTRQDGTGGKSIWGKKFEDEFDASLHHDRKGVLSMANSGPKTNGSQFFITLDACGHLDGKHTIFGQVVDGMDIVDKLGSVKTGELDRPVKEVMIVKAQSFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R7N0</accession>
    <name>A0A3D8R7N0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Purine nucleoside permease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08325</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW69928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R7N0"/>
    <dbReference type="OrthoDB" id="2331083at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009486">
        <property type="entry name" value="Pur_nuclsid_perm"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38643">
        <property type="entry name" value="PURINE NUCLEOSIDE PERMEASE C285.05-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38643:SF1">
        <property type="entry name" value="PURINE NUCLEOSIDE PERMEASE C285.05-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06516">
        <property type="entry name" value="NUP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017729312" evidence="1">
        <location>
            <begin position="19"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW69928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="418" mass="44916" checksum="8F080EE0ECA0E53E" modified="2019-01-16" version="1">MRFSTVFSALASAALVTASPVSDLVKKHEEHGPPTGHHQEYASKIAPKVFIISMFSYEANIWYENAETEGSIGNLLEKNITVPGFSMLFPDAHCLADGSVCQLTTGESEINAASTISALMYSPYFDLTKTYFMIAGIAGINPKYGTLADVALSKYAVQVALQYEFDAREMPENWTTGYFPQGSYAPDEYPSSLYGTEVFELNEALRDIAVGFASTATLNDSATAIKYRANYNSSALYAAATQKPSVITCDVATSDVYFSGALLGEAFENFTTLVTNGSATYCMTAQEDNASLEAMLRAAITGLVDFSRIILMRTASDFDRPYLGDSVANNLLYNDVGGSTPAFENIYLAGTPIVKGILDGWNSTFAAGINATNYIGDVFGTLGGEPDFGPGSSYGGKGVVLSQVGLSRRDTYKKVMRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R824</accession>
    <name>A0A3D8R824_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Putative DNA repair and recombination protein RAD26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">BP5796_08478</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15 16">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R824"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22254">
        <property type="entry name" value="CSB_WHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18000">
        <property type="entry name" value="DEXHc_ERCC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000039">
        <property type="entry name" value="DNA repair protein Rhp26/Rad26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058951">
        <property type="entry name" value="WHD_Rad26_CSB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25875">
        <property type="entry name" value="WHD_Rad26_CSB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="439"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="768"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="168"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="234"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1134"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="99"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="211"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="236"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="259"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="333"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="1140"/>
            <end position="1155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="RDW70081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1229" mass="137547" checksum="A1EE8446A322FEC7" modified="2019-01-16" version="1">MSSSSATSVAIKSEALEASPDPALGTVKLHDEETNTIAEAAAVVADKALDSGNEVVQVSVLANDEASALKGLTADVRDQDDLERDITHQANLVMIEQEDDRDRKRIEKVDANIEKLQNQKRLQERRMNTLANNPLMRRRVTVEIERIEAEILGLHKDKTDIQGRIDERHQLNEVDSGDQADDTTNGNKRLPNESQREFLIRTGKITPFSKVPDRGPDGLRGDLSEVLMDAEDEANHDELRTEEAEPRSHQNLRLPGFASESNSSSSMTTPESEFSLRPRKKRKIERATSARATHNAEGDSADVFSPDPSEVDGAGFIEEEEDEEDDLMTSRTSTKRPAKKGKSKADEKVDLTGIDDGNEQMYQSRLRDWVEKRSSARCRKQDQEAPEGGEELALEQEEKEWFMPCPDAPDHHFENDIKLPGDIYPALFDYQKTGVQWLGELYNQQVGGIVGDEMGLGKTIQIISFLAGLHYSKKLTKPIIVVAPATVLRQWVNEFHRWWPPLRVSILHSSGSGMLNVRNEDDLSEEEMYSRKDKSQTKSSKAAKKIVDRVVKHGHVLVTTYAGLQTYNDVLIPVDWGYAVLDEGHKIRNPNTAITIYCKELRTSNRIILSGTPMQNNLIELWSLFDFVFPMRLGTLVNFRQSFEVPIKLGGYANATNLQVMTATKCAETLKAAISPYLLQRLKVDVASDLPKKSEQVLFCKLTKPQREAYELFLASDDMTSILNRTRQSLYGIDILRKICNHPDLLDPHLKGKPGYKWGNPNKSGKMQVVKALLEMWKNMGHKTLLFSQGVQMLNIIEEFVKGLDGFNYLRMDGSTNIKDRQSLVDRFNKEPDLHVFLLTTKVGGLGVNLTGANRVIIFDPDWNPSTDVQARERAWRLGQKKEVTIYRLMTAGTIEEKIYHRQIFKQFLTNKILKDPKQRQTFQMKDLYDLFTLGGADDDTTETGEMFKGTEVQFGNEPRPAPDKEVKRPVLMNPNSMHVPTLTADGTGISRLPLAQAPVAEEEPDTDVRNLTGVASLETFRGNEDEERPTTDEARLMEGIFARSGVHSALEHDHIINGKKVIAADRGMLEREAKRVAAEAAAELRKAGVAARSIEAGTVTWTGEFGSAGRPANIRRGVGGPSSAGILAGLADRQGLPVPSSSSSSRSGTPSTSERPPRGKDFMKLIREFIKRHGGSVPSQALVTHFDRMCRTAQQTAEFKHMLGEIAKLEKGPNSRMRGRWVLKDEFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="11" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8R8K4</accession>
    <name>A0A3D8R8K4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF1857-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_08776</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000012">
        <property type="protein sequence ID" value="RDW70379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8R8K4"/>
    <dbReference type="OrthoDB" id="2320332at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd08863">
        <property type="entry name" value="SRPBCC_DUF1857"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015075">
        <property type="entry name" value="AtaL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08982">
        <property type="entry name" value="AtaL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW70379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="160" mass="17953" checksum="D1ECDDDB88B04498" modified="2019-01-16" version="1">MVIINVAYTTAINPPSASPHLNPKQIWAGLQHKVRHAEEFVKPIESCQVLKEEGNTVTRQVKFAPGYSNTGKQLATEVCTEYEGVKVNFLQEDGSMIQNIVSEGENGEMFLTYVFEWFRDDVKAGSEEEQKMKTQYAPMARTAVHGTLDTVRKMAQDGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="19" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCT8</accession>
    <name>A0A3D8RCT8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phospho-2-dehydro-3-deoxyheptonate aldolase</fullName>
            <ecNumber evidence="8">2.5.1.54</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_07772</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>D-erythrose 4-phosphate + phosphoenolpyruvate + H2O = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:14717"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16897"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58394"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="EC" id="2.5.1.54"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 1/7.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class-I DAHP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.54" evidence="8"/>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RCT8"/>
    <dbReference type="OrthoDB" id="4699125at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003849">
        <property type="term" value="F:3-deoxy-7-phosphoheptulonate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009073">
        <property type="term" value="P:aromatic amino acid family biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000005">
        <property type="entry name" value="Phospho-2-dehydro-3-deoxyheptonate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006218">
        <property type="entry name" value="DAHP1/KDSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006219">
        <property type="entry name" value="DAHP_synth_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00034">
        <property type="entry name" value="aroFGH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009395">
        <property type="entry name" value="PRK12755.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE DAHP SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21225:SF12">
        <property type="entry name" value="PHOSPHO-2-DEHYDRO-3-DEOXYHEPTONATE ALDOLASE, TYROSINE-INHIBITED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00793">
        <property type="entry name" value="DAHP_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001361">
        <property type="entry name" value="DAHP_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6 8" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAHP synthetase I/KDSA" evidence="9">
        <location>
            <begin position="48"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR001361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW71738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="363" mass="39129" checksum="3C21AF34D6301F3E" modified="2019-01-16" version="1">MPALEIQPDVTDDTRILGQDPLIPPQLLVSETPATANAIRTVVQGRREAVEIIMGQSDRLLVVCGPCSLHDPATALEYAARLRKLADKLSGDLCIIMRAYLEKPRTTVGWKGLINDPDIDESFKINKGLRISRQLFCDLTNIGMPIATEMLDTISPQFLADLISLGAIGARTTESQLHRELASGLSFPVGFKNGTDGSLAVAIDAIGAAAAKHHFMGVTKQGLAAITRTNGNEHGFVILRGGTKGTNYDAESIKQTKEVLTKKNEKQAIMIDCSHGNSNKDHRNQPKVAKVIGEQLRAGEKSIIGVMIESNINEGNQKVPAEGPAGLKKGVSITDACINWESTVEVLEGLAEAVRERRQVNAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RCX0</accession>
    <name>A0A3D8RCX0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">ABC transporter domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_07916</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="245989at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03233">
        <property type="entry name" value="ABCG_PDR_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03232">
        <property type="entry name" value="ABCG_PDR_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001010">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000054">
        <property type="entry name" value="ABC multidrug transporter atrF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029481">
        <property type="entry name" value="ABC_trans_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034001">
        <property type="entry name" value="ABCG_PDR_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034003">
        <property type="entry name" value="ABCG_PDR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010929">
        <property type="entry name" value="PDR_CDR_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19241">
        <property type="entry name" value="ATP-BINDING CASSETTE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14510">
        <property type="entry name" value="ABC_trans_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06422">
        <property type="entry name" value="PDR_CDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="525"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="602"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="634"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="667"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="694"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="777"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1193"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1222"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1261"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1300"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1328"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1453"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="166"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="852"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="817"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="94"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW71882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1479" mass="163754" checksum="F1B7896A2EAFA144" modified="2019-01-16" version="1">MDEKHIYEPTPGAVDGAPRPSTSTDADAEIERENVRHANPNGFSNPKGGVNVSDAEAEFAQLQRELSGISQRSKQLARSKSNQSTKQKDVEKIATSASSSETESQFDLEQTLRGNQAAEIESGIRPKHIGVVWEGLTVRGTGGVSNFVKTFPDAFVSFFNVFETALNIFGVGKKGMEVDILKDFRGLTKAGEMVLVLGRPGSGCTTFLKVIANQRFGYTGVEGDVLYGPFDSKTFSNLYRGEAVYNSEDDVHHPTLTVAQTLGFALDTKTPGKRPLGMSKSDFKDRVITTLLRMFNIEHTRNTIVGNQFVRGVSGGERKRVSIAEMMVTNATVCSWDNSTRGLDASTALDYAKSLRIMTNIYKTTTFVSLYQASENIYKQFDKVLVIDSGKQVYFGPANEARAYFEGLGFKEKPRQTTPDFLTGCTDEFEREYADGRSAADSPHDADSLANAFLASKHSQNLSDEMQSYRKTVAEDKQKYDDFQIAVQESKQKGASKKSVYSVPYYLQIWALMQRQFLIKWQDKFSLVVAWITSVVIAIVLGTVWLNLPKTSAGAFTRGGLLFISLLFNAFQAFSELASTMLGRPIVNKHKSYTFHRPSALWIAQILVDVAFSATQILLFSIIVYFMCGLVRDAGAFFTFYIVIVAGYLAMTLFFRTVGCLCPDFDYAIKFAATIITFLVVTSGYLIQYQSEKVWLRWIYWINPLGLGFSALMENEFGRLTLTCEGTSLVPSGVGYNSIQNQVCTLAGSVTGTDQVSGSAYITQGFSYLPSQLWRNFGIIIALIVGFLISNATLGEWIVYGAGGNSAKVFQKPNKERDELNAALRAKRDARREKKQEESEGSELSINSKAILTWEGLNYDVPTPAGELRLLNNIYGYVRPGELTALMGASGAGKTTLLDVLASRKNIGVISGDILVDGIKPGNSFQRGTSYAEQLDVHEPSATVREALRFSADLRQPFHVPQAEKYAYVEEILSLLEMEDMADAIIGDPESGLAVEQRKRVTIGVELAAKPELLLFLDEPTSGLDSQSAFNIVRFLRKLAAAGQAILCTIHQPNAALFENFDRLLLLQRGGRCVYFGDIGKDAVTLRGYLSRHGADCPPDANVAEYMLDAIGAGQAARVGDRDWAEIFADSPELANIKDRISQMKTERLADVGSNPKSDEREFATPLMHQLRVVQKRTNLAFWRSPNYGFTRLFNHVIIALITGLTYLNLDQSAESLQYRVFVIFQVTVLPALILAQVEPKYAISRMIYYREASSKMYSQFAFASSLVVAEMPYSILCAVGFFLPIYYMPNFSKVSSRAGYQFFMVLITELFSVTLGQAVAALTPSPFISALLNPFIIITFALFCGVTIPKPQIPKFWRAWLYQLDPFTRLIGGMVVTELHDLPVVCKTSELSHFSAPSGQTCGEYMSNFFAAGGAGYLTSNSTSDCSYCAYSVGDQFYTPLGFSFNNRWRDLGILIAFIGSNLIILLLASRYLNFNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RDC4</accession>
    <name>A0A3D8RDC4_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphotransferase</fullName>
            <ecNumber evidence="6">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">BP5796_07908</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9 10">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="6"/>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW71874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RDC4"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019158">
        <property type="term" value="F:mannokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF24">
        <property type="entry name" value="PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="7">
        <location>
            <begin position="86"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="8">
        <location>
            <begin position="282"/>
            <end position="526"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="RDW71874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="536" mass="58258" checksum="9B58159448961D4F" modified="2019-01-16" version="1">MQPFKAAMLSVREAFYAAFLRSLLRTKSLLQTILNIWIGPRKLAKEPDAQSEGSSPQDGVVVLSQTKRREVADFVEEVARLFRDPTSRQNLVALSDGLKTQFEESLVDNAQCMLPSYQHQLPTGEECGTYLALDVGGSTFRVALIELAGRGSESKVVRRSTTKIDATIKNLQGVAFFDWMAERIEETLSGQSEGHELNSAPLPMGLAWSFPIEQTSLRSGLLLGMGKNFMAAHGIIGQDLGDLIQNACSRKNLNVSLQAIVNDSSACLLASAFTSHTPPTRLSLILGTGCNAAVHLPVSSFSPQKFGIRPSSWHSAATHVIVNTELSMFGGRVLPFTRWDRQLLVKHPRPDFQPLEYFVGGGYLGEIVRLVLVEAIETTGIFGGIVPAGLEEPYSLDTETVSRIEADTTAHLAPSLTLFTNLYPTSYAYTHSDLSTLRHLASHIIHRATAVIATGLYTLYLLRSSTSSSISAKMQIAYNGSVMEQYPGFKELAQHHLELLVGSKGVLTLVPADDSSLLGAAVAVACLDPDEVIKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RE10</accession>
    <name>A0A3D8RE10_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_08210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000011">
        <property type="protein sequence ID" value="RDW72176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RE10"/>
    <dbReference type="OrthoDB" id="2399539at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="13"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW72176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="276" mass="30470" checksum="4C59E3C552234E08" modified="2019-01-16" version="1">MAKVIGITAPTASQSRQGSFSGSGLETEASKRRTKKSRASVACSSCHAKKQRCGSESGPSKHYIQALEKRLLETESVLFTTISILTHNQPFLPLFQHTENYANCFSNSAIDQFYQFHRGNKFGIEYWTEFGLESEAKIARWFQDHGGVLQQPVSNNHQRSQNTTLGRDCGGDYVSNSIEHDAVESNQMIDIVGITPVRVACSRSQSPETALDANSRDFSYNRNPQVEKATGRSSLYAVVDPGLQDHPAALDVGTSSISMVAPESQNARLTDEEFLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RHV5</accession>
    <name>A0A3D8RHV5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">alpha-galactosidase</fullName>
            <ecNumber evidence="2">3.2.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_07065</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.</text>
            <dbReference type="EC" id="3.2.1.22"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.22" evidence="2"/>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RHV5"/>
    <dbReference type="OrthoDB" id="2108802at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004557">
        <property type="term" value="F:alpha-galactosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004352">
        <property type="entry name" value="GH114_TIM-barrel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35273">
        <property type="entry name" value="ALPHA-1,4 POLYGALACTOSAMINIDASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G07890)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35273:SF2">
        <property type="entry name" value="ALPHA-GALACTOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03537">
        <property type="entry name" value="Glyco_hydro_114"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside-hydrolase family GH114 TIM-barrel" evidence="4">
        <location>
            <begin position="86"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW73623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="317" mass="34362" checksum="B416817C0745A693" modified="2019-01-16" version="1">MRLTSGYKFAGPESPGGLLGLWNAHKKVFLICGSIIAVLVIALAVALGVGLHSSSHDNSGGVTPNLNYSVANATQFSGWNPEAGVTWQIVLQSALNDTSADVDVYDIDLFTNSASTISTLQRLGRKVICYFSAGSYEDFRPDSSDFQKTDYGKGLDGWQGEWWLNTNSSNVRAIMIKRLDLAVQKGCDGVDPDNIDGYDNDTGLDLTEDTAIEYLTFLASEAHSRNLAIGLKNGGNIVNQTLAMMQWQVNEQCEQFSECGLYTPFITANKPVFHIEYPSSAPAVSADTKSTICDNPAIAGFSTVIKKMILDAWIETC</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RII9</accession>
    <name>A0A3D8RII9_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">VanZ-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_07232</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RII9"/>
    <dbReference type="OrthoDB" id="63581at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006976">
        <property type="entry name" value="VanZ-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF037970">
        <property type="entry name" value="vanZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28008">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28008:SF1">
        <property type="entry name" value="DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G10980)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04892">
        <property type="entry name" value="VanZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="37"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="60"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="VanZ-like" evidence="3">
        <location>
            <begin position="34"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW73790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="208" mass="23203" checksum="FCDAD2DF272DCCE1" modified="2019-01-16" version="1">MRIRLPFAGAFVFLIFLSAYAGLTSLQLDGLINDKVLHFVTFFILTTCFYWILDTTRRRNLNLTLLICTGFLGVGSEILQGVLPNDRVFDVYDIVANVVGSLSSVALSSWYHLRMLERKRLAKTYQVVPDEEQDLELGEGVGAQESGIARVEPRAETLDEEVDNWDENAEDGWEEEDHGLESNDGEGLKTPSASSAGEIEPDAKKRSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIS7</accession>
    <name>A0A3D8RIS7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Condensin complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_07193</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the CND1 (condensin subunit 1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIS7"/>
    <dbReference type="OrthoDB" id="436262at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000272">
        <property type="entry name" value="Condensin complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000920">
        <property type="entry name" value="Condensin complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032682">
        <property type="entry name" value="Cnd1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007673">
        <property type="entry name" value="Condensin_cplx_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024324">
        <property type="entry name" value="Condensin_cplx_su1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF2">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12717">
        <property type="entry name" value="Cnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12922">
        <property type="entry name" value="Cnd1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20168">
        <property type="entry name" value="PDS5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017127">
        <property type="entry name" value="Condensin_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="6 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensin complex subunit 1 N-terminal" evidence="13">
        <location>
            <begin position="111"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Condensin complex subunit 1 C-terminal" evidence="12">
        <location>
            <begin position="1037"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="843"/>
            <end position="886"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="921"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="850"/>
            <end position="860"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR017127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF12717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW73751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1220" mass="136015" checksum="9846246F8AEE6043" modified="2019-01-16" version="1">MDNIEFDINDALKHYMSDPATISTPEADSNLVDCENDPESLTNSLINTVLNPIVDSVAENPDAITRSSSFDSLQFLLKCVPTSFISHQKPLSQPVAELFKLSRNTAVLPTHALSKVFDLIISGLATEADIIHNDLESDEQELIAHHKQLLEVYGFLLQWTIAAVETKAAEKPTTVPTARGRGKAAKSKASAKDGAWDSTAQLQTALDVMCKVLKLKLSKIFLTTSERDTFIGLLTRPVYMVLESEQRVKNTAIRMHGFKVLCIAVKHHGHGYAAQISIVQNLTYFEHLAEPMAEFLHILSEQYDYPQLADEVLRELSNKEFNSNDTRGPKSVSAFIVKISELAPRLVMKQMTLLAKQLDSESYALRCALIEVCGNLVADLSKQEERGDNHKSQLNAFFDVLEERFLDINPYCRCRTIQVYVKICDLDQKFPKRRQKVAELAARSLEDKSSNVRRNAIKLLGALIKTHPFGMMHGSQLNYKEWNARLDAVDAELNALKPPAGTPGLVEGPKVDAALLDDATVLESESPEKPLTDEQKIAIIKKAQEDAATSEAISKLSLTRRYYVEALKFIEVLHGATTTICQLLGSKNKSEVIEAMEYFEIGDAYNIEQNKLGIRRMLRLIWTKGNSDEGKGVQTHLIECYKRLFFEAPDSYSGNDAANYIARNMISLTFGATPAELTSLEQLLSTMMNAGHVSDLVVTKLWQVYGVQKREISKTQRRGSIIVLGMLATAKPEIVVGEMETMLRIGLGSLGRSDLALAKYTCIALRRINPTGRQAKDTATSKLPNDHAVLGKLAAMIEIESDSKEWYGVAEQAISAIYTLSKHPDTLCSEVLRRKTKYVFSQRTAKVEEEPQVDMMDVDEPEHPEGDEGAPPTPPPETVAEPESKQKGSVALSQLLFIVGHVAIKQIVHLELCELDFKRRKTDSEKNKPAAEKPEDKAAKEAADDLDMIGGTTEDDFTEAMNHIRERELLYGEHSLLANFGPLVSEICSNNTTYRDRNLQAAATLCLAKLMCVSSEYCEANLPLLITILERSKDPITRSNVVIALGDMAVCFNHLIDENTDFLYRRLNDKDASVKRTCLMTLTFLILAGQVKVKGQLGEMAKCLEDDDKKIADLSRMFFTELSTKDNAVYNHFVDMFSLLSAEKDLEEDSLKRIIKFLAGFIEKDKHAKQLADKLAARLARCESERQWNDVAYALSLLQHKNEEITKLVSGGFRVVQASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIW2</accession>
    <name>A0A3D8RIW2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Chromatin modification-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BP5796_07431</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Component of an histone acetyltransferase complex.</text>
    </comment>
    <comment type="function">
        <text evidence="12">Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in cell cycle progression and meiosis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="16">Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 16">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="16">The PHD-type zinc finger mediates the binding to H3K4me3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the ING family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIW2"/>
    <dbReference type="OrthoDB" id="2505961at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16858">
        <property type="entry name" value="ING_ING3_Yng2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15505">
        <property type="entry name" value="PHD_ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333:SF100">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN YNG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7 16" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3 14 16" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 16" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 15 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="18">
        <location>
            <begin position="367"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="186"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="241"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="17">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="17">
        <location>
            <begin position="299"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="328"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="17">
        <location>
            <begin position="351"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="372"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="383"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="388"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="394"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="397"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="413"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="13">
        <location>
            <position position="369"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="13">
        <location>
            <position position="380"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="13">
        <location>
            <position position="384"/>
        </location>
    </feature>
    <feature type="site" description="Histone H3K4me3 binding" evidence="13">
        <location>
            <position position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00037044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU361213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RDW73989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="421" mass="45776" checksum="11A7C9B278DCCB10" modified="2019-01-16" version="1">MPRDDLSIDFVPNRRIMVITDHQDCGSVLEEFTNRVANLPAEIAFMQDEITEKDRMVEKLRSTASRADLQIQQWIRENGSHTPNPKEEKLKKVFDENMSKALQLQAEKLALCDKMEHVYHRHLLQLDKEIKKLQDRGEFPKEDVPSVFDDNGPAPINRVRVPGAVPAPLGPIANNATPVVHTRHPNQHPMRAPTVQSQSPQVPGASVSVPTTPAAAHLMSQRAREMSLGAVANKRQRLIGGLGALPSNSSGLARPPVGPGTPKPGTPSSSRAGSIGPRASQKSGATTKKVAPHRQGVAARKKIIKSNLGRIKHRSGNKNSPSSANDSELSDPESGSGEDDDEAMSPTRGEGDDELGDLEDDEGADDKKYCTCQSVSYGDMVACDNESCPFEWFHWSCVGLTKEPTGTWICPVCTKNGVKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RIZ0</accession>
    <name>A0A3D8RIZ0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative calmodulin-dependent protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_07340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW73898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RIZ0"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000257">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000153">
        <property type="entry name" value="Calcium/calmodulin-dependent protein kinase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="338"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="384"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW73898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="431" mass="47239" checksum="BCB6DEF9A5D68B93" modified="2019-01-16" version="1">MSYQNSQDGQQAKAAVQACRYKTGKTLGAGSYSVVKECVHIDTGRYYAAKVINKRLMAGREHMVRNEIAVLKRVSMGHQNILTLVDYFETLNNLYLVTDLALGGELFDRICRKGSYYESDAADLIRATLSAVAYLHDHGIVHRDLKPENLLFRTPEDNADLLIADFGLSRIMDEEQFHVLTTTCGTPGYMAPEIFKKTGHGKPVDIWAIGVITYFLLCGYTPFDRDSNLEEMQAILVADYSFTPIEYWRGVSLSAREFIKRCLTIDPTQRLTAHEALSHPFVSGIETTAKGTKGSDLLPVVKKNFNARRTLHAAIDTVRAINKLREGQSGMMDGIVSNAPDQGAPPLPKARNKDSGVGGVGGDPNAMDHDSGTGSGDNGLFGHGDTDVHMRGVERNTGQGQTEAQIEAQKRRIAETTKGLWSSGAAKITGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJJ7</accession>
    <name>A0A3D8RJJ7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_07463</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJJ7"/>
    <dbReference type="OrthoDB" id="5342924at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="194"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW74021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="737" mass="81418" checksum="F0820D6167C3A769" modified="2019-01-16" version="1">MANTVSVPLSSNETSSVEASIHVPLLDFAQSLSFSSSITRQPPSIGNSIGASDGSVPENGSDKTSANQEPRKVALEKNRGPGLWRYLIHLFPLLMTAGILSLSFGNIYWTDIGGKSQNSILNLLQFVAKLHEVLINASLSSIVLHRIRQGMISSTGIPLGFATSGYQVSSVDYITSKQFWGALLGDHWRLARNLIPTGLLILIAFMLTTVVGPASAIAMIPKLDWWPTDMPVRVFTNTTFDAMWPQYLSGARLDGTNCYNDTEFDKIDTSCPGYGFTYINAYARSYRRFGNLPNITTAMEGNVIRYISSTSPSILNKSVTSSVAVQQSRVLGFLWEHALAKKLSIANASRPSIDMSLGERSIKKPVVQVQCSAYYHPNTAIDMNFPHDQLTTSPLDKESDTTWPIPGDLQFPTLAQTSEASGHGWNAFRWVNLSSYRNGPSLAGVFTLTTEDSPYEAVVFPCTVDARWAPVDMWLDPWVDLFIRQNTSDPNSTVPHLTAQDQIFMDDGWALALSNDTINNKSENGRPGRQSIPRLVADLGKEISNNHWVLSAGPPEYYPWTLSVILGMYVTDAIARASPNVTTFVYQANSSGEETVSLLRSTNIPFKHPKTSEQAAKNPRLTEYTLKANRYGYGWSMKSLTIRFAAAALLSHAVMAMVHIFFSLHDQWICTAWETMGALLVLAINSPSSDKLLGTSVRVGKMRTWKELVRAREGRDGHLQLSLVEEGNRILPEKKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RJS8</accession>
    <name>A0A3D8RJS8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent RNA helicase DED1</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">ATP-dependent RNA helicase ded1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">BP5796_07596</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21 22">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="PDLN01000010">
        <property type="protein sequence ID" value="RDW74154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RJS8"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17967">
        <property type="entry name" value="DEADc_DDX3_DDX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000160">
        <property type="entry name" value="ATP-dependent RNA helicase DDX3X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044763">
        <property type="entry name" value="Ded1/Dbp1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 16" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="20">
        <location>
            <begin position="178"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="18">
        <location>
            <begin position="209"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="19">
        <location>
            <begin position="410"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="577"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="649"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="15">
        <location>
            <begin position="178"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="17">
        <location>
            <begin position="577"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="RDW74154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="673" mass="71015" checksum="A045A3E65C2F1A64" modified="2019-01-16" version="1">MADQIAQGMGNMKLNGQPEGRSYIPPHMRGQPGGPGPMAGAPPMNGGGLNGSAWAAPQAANGYGGGPKPGDWANTPEFTPRGGNGPSRGGWDSRGSDGPKFNPNSYGGASAGGNQARGGGDGQWRDGKHIAGPANPRVERELFGVADDPTKQQTGINFEKYDDIPVEASGTDVPEPVLRFTNPPLDDHLIRNIELAHYKVPTPVQKYSIPIVMGGRDLMACAQTGSGKTGGFLFPILSQAFIHGPSATPGTGGNFGRQRKAYPTSLILAPTRELVSQIFEESRKFAYRSWVRPCVVYGGADIGSQLRQIERGCDLLVATPGRLVDLIERGRISLQNIKYLVLDEADRMLDMGFEPQIRRIVEGEDMPNVQNRQTLMFSATFPRDIQMLARDFLKDYVFLSVGRVGSTSENITQKVEYVEDMDKRSVLLDILHTHGAGLTLIFVETKRMADSLSDFLINQNFPATSIHGDRTQRERERALEMFRNGRCPILVATAVAARGLDIPNVTHVVNYDLPTDIDDYVHRIGRTGRAGNTGISTAFFNRGNRGVVRDLIELLKEANQEVPAFLENIAREGAGFGGGRGGGRSGGRGRGGAANRDFRKFGGGGGAAPGYGGGFGGPPAGNGYGGAAGGFGGAPAPAYGGSGGFSSGGGGGYSGGGGGSYGNPSGGGGQSWW</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="15" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RNR6</accession>
    <name>A0A3D8RNR6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ASST-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_06421</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RNR6"/>
    <dbReference type="OrthoDB" id="5427350at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053143">
        <property type="entry name" value="Arylsulfate_ST"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039535">
        <property type="entry name" value="ASST-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340:SF5">
        <property type="entry name" value="ASST-DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35340">
        <property type="entry name" value="PQQ ENZYME REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14269">
        <property type="entry name" value="Arylsulfotran_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017581201" description="ASST-domain-containing protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="508"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW75600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="566" mass="63328" checksum="05C612EE038E44F3" modified="2019-01-16" version="1">MRTSMAGLLLLWPLAAHALSWSAYDLGLYGISPTQHYVSTAFTSPQMNILQWDARCERDGAYVLISPRGYQVENPGPIMLDNRGNLVWTETRFGQVTNLQVQQYRGESYLTFWAGASYGPHSNGSYYMLDSAYEIAKKVDAVGPDVAGDLHEFKITDNNTALMTIYQDHEVACSRLGIDSSSSCWINDGLFQEVDIETGDLIFQWRASDHVKISDSYKGRGSEGTSKENSYDYFHINSVHKDPLGNYYISSRYMFTVYCISPAGDILWYLGGKNNNFTDLSGGYATNFAYQHHANWHENNTFTIFDNNGNNVFHNPSEFSRGMTISLDLTAMTATLLRTYVHPDRILAISQGSTQQLPDSGNVFVGWGNSPAYTEFTGEGEVLCNVHYGAGLFFELIDLGWVKSYRSFKGQWIGKPKTRPDIKVVGGQVYVSWNGATELAGWRLQSAASADATDEDFEDVDELPRETFETAFVLGDVEGAFFRAAALDKSGAVLGYTNVTQSTPEPTVTPFLSIIFLALFLLGFFLVVRRYRSTISRQLWKISSSRKISPQQYELLNSDEEPNIRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RNV1</accession>
    <name>A0A3D8RNV1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cupin type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_06395</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RNV1"/>
    <dbReference type="OrthoDB" id="1161823at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd02223">
        <property type="entry name" value="cupin_Bh2720-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013096">
        <property type="entry name" value="Cupin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052538">
        <property type="entry name" value="Flavonoid_dioxygenase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43346">
        <property type="entry name" value="LIGAND BINDING DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_6G14370)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43346:SF1">
        <property type="entry name" value="QUERCETIN 2,3-DIOXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07883">
        <property type="entry name" value="Cupin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cupin type-2" evidence="2">
        <location>
            <begin position="43"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW75574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="162" mass="17476" checksum="13B5381C0F28268A" modified="2019-01-16" version="1">MASKSGPPAHEMAYFPNICGALSESSAEFRKVLWTGLYSQVVLMTIPVGGDIGDEVHTVDQALTFTSGIGKATINGKDQDVKAGDLMVVPAGTQHQFINTGPTPLILYTIYSPAEHAPHTVHHDKKQADEEEEAGIDEAPEWSQRSKKENEALGLVNISGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RP43</accession>
    <name>A0A3D8RP43_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptide hydrolase</fullName>
            <ecNumber evidence="3">3.4.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_06683</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase M28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.-.-" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RP43"/>
    <dbReference type="OrthoDB" id="3907302at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016603">
        <property type="term" value="F:glutaminyl-peptide cyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03880">
        <property type="entry name" value="M28_QC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.10:FF:000074">
        <property type="entry name" value="Peptide hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037457">
        <property type="entry name" value="M28_QC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007484">
        <property type="entry name" value="Peptidase_M28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040234">
        <property type="entry name" value="QC/QCL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12283:SF6">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04389">
        <property type="entry name" value="Peptidase_M28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017498052" description="Peptide hydrolase" evidence="3">
        <location>
            <begin position="22"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M28" evidence="4">
        <location>
            <begin position="119"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW75862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="380" mass="41953" checksum="DA1524C6301297EC" modified="2019-01-16" version="1">MVSVQSILFLACTLFLLHARGYTTLSDETLRSIPAAGADFDIKTGALLAPILIPRVPGTPGSTKVLQHFVDFFTTQLPKWRIEYQNSTSKTPATGDKDIPFANLIITRDPPWTEPGNVGRLALVAHYDSKLSPAGFIGATDSAAPCAMILHAARSVDEALTKKWEAMEAAGLGDRELEEEVGVQIILLDGEEAFISWTNEDSLYGARSLAETWEGTPNPALSNYRSALSSITLFFLLDLLGASKPRIPSYFKTTHWAYQHLASIEARFRSLSLLESTVDQPFLPESAKHADQFNAAWMVQDDHIPFMARGVEVLHIIPTPFPRVWHQITDDGEHLDMPTTQDWAKIVTAFVAEWMDLEGHFPPASPIAQAKRAVTSKTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="9" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPW0</accession>
    <name>A0A3D8RPW0_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_06809</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW75988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPW0"/>
    <dbReference type="OrthoDB" id="3512661at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW75988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="284" mass="32803" checksum="33FF37F0442CC9E6" modified="2019-01-16" version="1">MEAVSTFGEGTKSMEGNYIEYAQDYGYYWFGPLPENLEITRGIHYRFLLKLASFMLCRSPQVVPNRTFIRNSSSAKDFGNTRFSKGNIFRYDDRIDAAQNYDLIRCMAHEIMAHLLAPKVHGPDQIEEWLYEGIANAFSICLPFRPPIQFRDGKYHQATLNMLCQKYYTSPMLHAGFEELQAQATNNEYAREQLSARAWAFVVCTDFRARDLVGGKVGGVQQRPVEDLAVKVMIKSRHEGKPYGLQQWFERLEPLMGDESKALFTKMDKGEVFVFRSKHWCQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RPZ3</accession>
    <name>A0A3D8RPZ3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_06968</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RPZ3"/>
    <dbReference type="OrthoDB" id="3172332at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052360">
        <property type="entry name" value="Transcr_Regulatory_Proteins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206">
        <property type="entry name" value="ASPERCRYPTIN BIOSYNTHESIS CLUSTER-SPECIFIC TRANSCRIPTION REGULATOR ATNN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36206:SF4">
        <property type="entry name" value="HYPOTHETICAL CONSERVED PROTEIN (EUROFUNG)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="7">
        <location>
            <begin position="40"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW76147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="532" mass="60550" checksum="F24404D8DDDEA489" modified="2019-01-16" version="1">MALSAKAANAVPSSLVLHFKAPAAAAAKELRTSRGRSRRGCKTCRLRRVKCDESRPVCQNCVKAQRVCDYHAIRRFVAVDFQEPQLPSAQMALCISPGTSQERRAFDLFQNSTSIELSGLFAPDFWQQSVLQLGQGSKCLRHAIVAISSIHERFAQGTDMSCQIIRVAKDPQYMFAVKQYNAAIRELYTALANNDCAPEVMLSCCMLFICFESFRGSPSTAMMHLQSGLQAIQAWKKGDLSTRMKLTDPTTRQILGLAARLGPQLTNIDMLDIEDFGATEVDIIQQSGDIFEGLANLSIYDPGDRFNSFEEARDEFNHIVNMELCYFYQINPLYTPTTHDPNKLPNLLKETLFRFNNWASAFEELCADQSRRMTSEDIATRLFLQVQYKFTIILINCIFMPNTEGFSSEEIDAYFLAWTPQFRECLELIEELISLSQQSMKKNSTRRNSTFHPEVGIIAPLFLLGLGARDPYVRRRTMELLKSEKRREGTWDSETCWKVLDFIVTNEKPIVLGYLNKRYKLYEHFVFVGEGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RQ01</accession>
    <name>A0A3D8RQ01_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Parasitic phase-specific protein PSP-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_06978</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000009">
        <property type="protein sequence ID" value="RDW76157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RQ01"/>
    <dbReference type="OrthoDB" id="4521223at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007568">
        <property type="entry name" value="RTA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465">
        <property type="entry name" value="PROTEIN RTA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31465:SF7">
        <property type="entry name" value="SPHINGOID LONG-CHAIN BASE TRANSPORTER RSB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04479">
        <property type="entry name" value="RTA1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="25"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="113"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="153"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW76157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="322" mass="35433" checksum="09ABA7F05980F46B" modified="2019-01-16" version="1">MPGFGNCTLDTCNVQASIFQYRPSLGANAAFIALFGIAFVFHLLQGLRWRTWTFMGLVLCGCASEMIGYGGRIMMSGNPWNFTGFMLQIGAKFLSWVQYLSRNSKRQYHGGANIPYTVCVAFAPVYFTAAIYITLYRTILYLSPASSRFAPKIYYIVFIPCDIISLVLQAIGGAKSTQTSGSSQSAIDIALAGLAFQVGTLCIFIALSLDFALRYRRDLQTGAVRTRNIPARFKIFVGFLTLSILCILVRCVYRIDELSNGYEGPLIHDQGLFIGLEGVMVIAAVFALNVGHPGQIFTEADVAPQSEDDIPSESMRIKHRDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RVS1</accession>
    <name>A0A3D8RVS1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Splicing factor U2AF subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">U2 snRNP auxiliary factor large subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_06005</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Necessary for the splicing of pre-mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the splicing factor SR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RVS1"/>
    <dbReference type="OrthoDB" id="10266058at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12231">
        <property type="entry name" value="RRM2_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000097">
        <property type="entry name" value="U2 snRNP auxiliary factor large subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006529">
        <property type="entry name" value="U2AF_lg"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01642">
        <property type="entry name" value="U2AF_lg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 7 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="261"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="382"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="490"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="33"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="59"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="85"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW78153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="585" mass="64042" checksum="3AF90A4CFD2098C0" modified="2019-01-16" version="1">MNGDSYSSRGMAPSTKVKQEDRAATNNTGSTDGGRHGSSRDYPSRDDRRGDRDRGSDRRRSRSPGHRGSRPSRRDGEVDSYSTSRDYREREREDRYSGRDRRGGGEREWDRDRGSARRDARRDDDDRPPRRDRDLFDDRRGGGGRRGDRGDRDGGFGGAGGGGRDRKKSASPPPKKKEPTPDLTDVVSVLERKRRLTQWDIKPPGYENVTAEQAKLSGMFPLPGAPRQQPMDPSKLQAFMAQPSGSVTNAALKPSNSRQAKRLLVHNLPPTVTEEAIVSFFNLQLNGLNVIEGSDPCISAQISKDRSFALLEFKNPSDATVVLAMDGITMEEHHAAAKNGASNGSATGLSIRRPKDYIVPAVTDETPYEPGTVSSVVVDTQNKISVSNVPLYLTDEQVTELLVSFGELKAFVLVKDNGTDESRGIAFCEYVDPAATDIAVEGLNGMELGDKHLKVQRASIGNTQASGLEMSVNAMSMLAGTTTQGLEDGRVLQLLNMVTAEELIDNDDYEEICEDVKEECEKYGKVLDMKVPRPSGGSRQSNGVGKIFVKFDTPESAGKALRTLAGRKFADRTVVVTYFSEASSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RW00</accession>
    <name>A0A3D8RW00_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Tho complex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_05833</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW77981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RW00"/>
    <dbReference type="OrthoDB" id="205166at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008501">
        <property type="entry name" value="THOC7/Mft1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05615">
        <property type="entry name" value="THOC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="210"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="90"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="228"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW77981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="340" mass="38756" checksum="A8B4C7A9A320D1BB" modified="2019-01-16" version="1">MSFQLLDTREEDELHKARLLNVEEKPFKRITKRLLTPGSLVSTPSKLPTPPPDSNDDAEVLHNDHQKTISQYREDVILDFAAFDSSIARIQFLRNSNERERERYKADKQRILETAQDVRDNTAQLRIQLQTAKNTLEQRKKFDELTEKITNNKLLRPRQDQEINLRKLEEECKDLERESMTYSETWKERREQFGRIVEEGMQLRRLIRDEKEEVERREGMNEDDGEDNASQGGQTPKHSSQSGNATPRPDPAHNSPDTGLKPRPLPAGSLSGNGSRSNSRAPSPAGSERRRTGPEEGEDVMMTDQTPAEGHTPRVTVDESSNTGTPAAEQGEIEDKMDTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RW97</accession>
    <name>A0A3D8RW97_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Restriction of telomere capping protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_05933</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May be involved in a process influencing telomere capping.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RTC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RW97"/>
    <dbReference type="OrthoDB" id="128308at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039024">
        <property type="entry name" value="RTC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028094">
        <property type="entry name" value="RTC4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR41391:SF1">
        <property type="entry name" value="RESTRICTION OF TELOMERE CAPPING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14474">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01312">
        <property type="entry name" value="RTC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Restriction of telomere capping protein 4 C-terminal" evidence="9">
        <location>
            <begin position="475"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="284"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="8"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="91"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009461"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW78081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="608" mass="67403" checksum="9F83E171FDC733C9" modified="2019-01-16" version="1">MATRERQNVYQGLNLTGRSNFNAPFKPPRPAMPQSRNASNSSLVETEPGLINPIEDIHAPPISSSDEDDCSANIKHTHFGSRAKSREETASSKPTSRSTTTAMTKKRNAGSIAKPPRPGRAQESRTPLGWTPGARHLKNKIPTYGKSKKLKAGQSFLTSRKPLQGNGSDGEDSVELESPRPAKLPVIAKNKTSRKRSISSSPRKELIDFSDIDDTPEKTKYGTPEAGLGWVDPAGICDSISPEPNRRLKDIASPLSNSTFIRPDSLSDDSSDLDRILSPADVDVKSTPLRRKSSVKSGFGEKIQRHSTKKRRKETREEDSEDEVQPAFVVPEGSDIAETSFDFKPIDFGEDDSLLNHVPDIAKAMAQEDGYGELLKGLDGAARRSSFLAERDANCTTISGIVCPVCNEPVDEDDLKAWIEKTGKKNLDFTQQTKFCRSHQKKSAKTKWQSKGYPEINWDELDSRVSKQHTLIKVLIRGGPCYYRTALDRAVKSGKHRTLKEMSSGLVPGYYGSRGLRVMQENIMKNFSALLKERAMKDRLISARGVPSFVQAVLVLEVACVLIMEDMKIEEEEARTVLKDSIRLGELVNDEAKEFVRKRASTDDELSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="10" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWK1</accession>
    <name>A0A3D8RWK1_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_06043</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWK1"/>
    <dbReference type="OrthoDB" id="3551079at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5017784036" evidence="1">
        <location>
            <begin position="19"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW78191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="92" mass="8658" checksum="ED5E691F59AD3692" modified="2019-01-16" version="1">MQFNVAAVFAAFAAVAAAQTVTVTVTECAASTSLASSAAASTVAASTYSVASTGVVTAPTATGSPITYAGAASMNGVSAFGMIVAGGVALFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWL3</accession>
    <name>A0A3D8RWL3_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NmrA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_06172</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NmrA-type oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8RWL3"/>
    <dbReference type="OrthoDB" id="3358371at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05251">
        <property type="entry name" value="NmrA_like_SDR_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008030">
        <property type="entry name" value="NmrA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051164">
        <property type="entry name" value="NmrA-like_oxidored"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748">
        <property type="entry name" value="NITROGEN METABOLITE REPRESSION PROTEIN NMRA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42748:SF30">
        <property type="entry name" value="NMRA-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05368">
        <property type="entry name" value="NmrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NmrA-like" evidence="4">
        <location>
            <begin position="2"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="RDW78320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="306" mass="34157" checksum="632AD53C7963B297" modified="2019-01-16" version="1">MAKLFTVFGATGQQGGALIKYLLAHPQFSTEYTIRGITRDAQKPAAIALKEQGVEIVEADLDEPSSLRGALAGSYAVFAVTNYWEKASASFEIAQGKAIADAAVSAAASLLIWSSLPRTGVEHFDSKAIVEDHIRTLPIKSFYFMPGWFMQNFLVIMKPRRKNEEGPFIMSKPWPNATANSLVPLVDIEDTGKYLEPFLLDPGRYNQATFMASTAFYTPTEICQTWSRVTGKKVEFDETADWVSTDYMSPEQKQKLTDSNVSRGSSYYGRKGKEGLEWTVAQIGKELTTWDSFVERNEPWFPEALI</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8RWP6</accession>
    <name>A0A3D8RWP6_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative multidrug resistance protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">BP5796_06325</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14 15">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000008">
        <property type="protein sequence ID" value="RDW78473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18595">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18603">
        <property type="entry name" value="ABC_6TM_MRP1_2_3_6_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000565">
        <property type="entry name" value="ABC bile acid transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000020">
        <property type="entry name" value="ABC metal ion transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000001">
        <property type="entry name" value="ATP-binding cassette subfamily C member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:004222">
        <property type="entry name" value="Os02g0288700 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056227">
        <property type="entry name" value="TMD0_ABC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24357">
        <property type="entry name" value="TMD0_ABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="103"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="133"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="164"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="535"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="568"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1016"/>
            <end position="1043"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1115"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1206"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="311"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="631"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="980"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1297"/>
            <end position="1532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="857"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="863"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="916"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="935"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="RDW78473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="1540" mass="171663" checksum="F8C1A87B7E308ACD" modified="2019-01-16" version="1">MPSQSQSILSTGSFSGFHSLAGLTSSGYLTAETTRHQPLCGNKEGWGPLSPTRYDFTPCFMDVWISTVALFGIVFGAGAIWWLVKRRTKSEVAKDWHFWTKQILIVAIAASVLVQLFFQIINYPDVWAGDFRFWTSFLTIISLGVIFSIQWLEHSRLRNPNGVVLFYWLFILIAFSVKLRSLISQQIYENHLPYFVAYCVGFGLSLIEFGLEWLVPKQKSAYEAIGDEDECPIEYATVFSILTFSWMTPMMKYGYKEYLTEDDLWNLAKRDTTQATGAVFQDAWQYELNNRKHPSLWVAIFRGFSGPYIRGTLFKTVQDTLAFIQPQLLRLLIRFVKSYETENPEPVIRGAAIALAMFAVSVGQTMALHQYFQRAFETGMRIKTALTAAIYSKSLRLSNEGRASKTTGDIVNYMAVDTQRLQDLAQFGQQLWSAPYQIVLCMVSLYQLVGYSMFAGVGAMILMIPINGLIARLMKKLQKEQMKNKDSRTRLIAEIINNMKSIKLYAWGSAFMQKLNFVRNDQELKTLRKIGAAQAVANFTWSTTPFLVSCSTFAVFVLTTDRPLTTDIVFPALTLFNLLTFPLAILPMVITSIIEASVAVGRLTSFFLAEELQEDAVIRMDPVEEIGEESITVRDGTFSWDRNEPRNALEDINFSASKGELTCIVGRVGDGKSSFLQAILGDLWKVKGQVVLHGSTAYVAQQAWVMNASVKENILFGHRYDPLFYEKTVKACALTEDFAQLPDGDETEVGERGISLSGGQKARLTLARAVYARADVYLLDDCLSAVDQHVGRHLIENVFGPNGLLSGKTRVLATNSIPVLMEADFIVLLRGGKILEKGTYNQLMAMKGEVMNLIKTASNQDQSTDSESSVTTSSASSTILGLPTDQEKEEMEEAQEGLTQLQPIRAGASRIKKRQNSGATLRRASTASFKGPRGKLRDEEEPNIKSKQGKEHSEQGKVKWDVYAEYAKTSNLLAVMIYGLMLIGGQTLQIAGSFWLKNWAEANGASGKNPRVGKYIGIYFAFGIGSSALVVIQTLILWIFCSIEASRKLHERMAFAIFRSPMSFFETTPAGRILNRFSSDIYRVDEVLARTFNMLFVNTARAGFTLVVISASTPAFVSLIIPLAALYLWIQRYYLRTSRELKRLDSVSRSPIYAHFQESLGGITTIRAYRQTARFAMENEWRVDANLRAYFPSINANRWLAVRLEFIGSIIILAAASFSIISVAGGSDLSAGFVGLSMSYALQITQSLNWIVRQTVEVETNIVSVERVLEYARLPAEAPEVIHRNRPPISWPASGAVHFNNYSTRYRPGLGLVLKGINLDIKPHEKIGVVGRTGAGKSSLTLSLFRIIEPSDGNISIDALNTSTIGLLDLRRRLAIIPQDAALFEGTIRDNLDPGHVHDDTELWSVLEHARLKEHVTTMTGGLEAKINEGGSNLSQGQRQLVSLARALLTPSNILVLDEATAAVDVETDALLQTTLRSPLFSKRTIITIAHRINTILDSDRIVVLEQGEVKEFDTPQALIEQRGLFYKLVKEAGLEGSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S2T7</accession>
    <name>A0A3D8S2T7_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase</fullName>
            <ecNumber evidence="4">4.1.3.44</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">tRNA wybutosine-synthesizing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">BP5796_05310</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19 20">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(1)-methylguanosine(37) in tRNA(Phe) + pyruvate + S-adenosyl-L-methionine = 4-demethylwyosine(37) in tRNA(Phe) + 5'-deoxyadenosine + L-methionine + CO2 + H2O</text>
            <dbReference type="Rhea" id="RHEA:36347"/>
            <dbReference type="Rhea" id="RHEA-COMP:10164"/>
            <dbReference type="Rhea" id="RHEA-COMP:10165"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64315"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="EC" id="4.1.3.44"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification; wybutosine-tRNA(Phe) biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TYW1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.3.44" evidence="4"/>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S2T7"/>
    <dbReference type="OrthoDB" id="271553at2759"/>
    <dbReference type="UniPathway" id="UPA00375"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102521">
        <property type="term" value="F:tRNA-4-demethylwyosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031591">
        <property type="term" value="P:wybutosine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000196">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001226">
        <property type="entry name" value="Flavodoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013917">
        <property type="entry name" value="tRNA_wybutosine-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034556">
        <property type="entry name" value="tRNA_wybutosine-synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13930:SF0">
        <property type="entry name" value="S-ADENOSYL-L-METHIONINE-DEPENDENT TRNA 4-DEMETHYLWYOSINE SYNTHASE TYW1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08608">
        <property type="entry name" value="Wyosine_form"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00284">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01071">
        <property type="entry name" value="tRNA_wybutosine-synthesizing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00201">
        <property type="entry name" value="FLAVODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0408">Iron</keyword>
    <keyword evidence="11" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="17">
        <location>
            <begin position="120"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="18">
        <location>
            <begin position="434"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="296"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="331"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="740"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="305"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="334"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="765"/>
            <end position="775"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00071388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00077859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="RDW80612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="775" mass="87051" checksum="32D203309B6A29A5" modified="2019-01-16" version="1">MPQNTWVQELLWPIDRTDLVAVWHTYRIPIILSTFTILCIFRAYLHLSVPRNKVSFTPPPSSPSLSSTKSTAPVKDVVEVRTVAEKSNAVQKAPRRIVGGLKKRKSSEEQLTTNDHQIQVLIFFSTLTGTTERAAKTLGQELRNRTGRFLEPQVVDLAEVDYDDYFISPPKSETDVQYFYLLMLPTFDIDTILDTFLEQLQETHNDFRIDTAPLSGLLGFSVFGFGDRDGWPTEETGFCSQAKDVDRWMAKLTGRKRAYPLGMGDIKKDAAGRLSDWKQGVEDVLDLIAETGGLGEGVVGSGDAVESDVEDEEEDDGEVVFDDENVALPKSKAKKDSVNDVEDLGKGLRTDASPSEAAEPSDTFEVDFTTYSKKSKPPPAPPVIKEMVPKSSPTYTALTKQGYTVVGSHSGVKICRWTKSALRGRGSCYKYSFYGIASHQCMETTPSLSCSNKCVFCWRHGTNPVGTTWRWVVDAPDMIFNGVKAGHYQKIKMMRGVPGVRAERFEEAMRIRHCALSLVGEPISYPYINEFTSMLHAEHISSFLVCNAQHPDQLATLKPVTQLYVSIDASNKESLRKIDRPLHRDFWERFQRCLEILRERRFEQRTVFRLTLVKGFNIEDEAEGYADLVEKGLPCFVEIKGVTYCGTSSSAGAGLTMQNVPFYEEVCAFVEALNAALARRGLGYGIAAEHAHSCCILIASDRFRVNGKWHTRIDYEAFFRCLESGKPFTPEDYMGPETPEWATWGKGGFDPRDERVHRKGKNKKPLPESKVEELF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="24" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S386</accession>
    <name>A0A3D8S386_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sensitive to high expression protein 9, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_05433</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for the maintenance of the structure of the mitochondrial inner membrane. Involved in mitochondrial morphology. Causes growth arrest when highly overexpressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Homooligomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion inner membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the SHE9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S386"/>
    <dbReference type="OrthoDB" id="5595506at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007007">
        <property type="term" value="P:inner mitochondrial membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008839">
        <property type="entry name" value="MDM33_fungi"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31961:SF3">
        <property type="entry name" value="SENSITIVE TO HIGH EXPRESSION PROTEIN 9, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05546">
        <property type="entry name" value="She9_MDM33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 10" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="421"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="72"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="153"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="94"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW80735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="447" mass="49520" checksum="52994FD4F030AE56" modified="2019-01-16" version="1">MQPLVRLVPRLAIDSISITTASRPLRQLRPSIKASICFQCRSQLQRRHFADGPNKRPESQGLPPLDEILAQRKAQPEPAKPPPPSPSPSPSPAPTQSTSQQAPQDEQEEELPSSEESRRLALTKRFSAIMDSVQGNIFVASQRLNDLTGYSGIEALKIRITKLEQRVQDAQEAVRTARQTYKTTVAERASTQREVTTLLARKDSWTPTDLERFTSLYRSDHSNEQAVQESATRLADAEREAEHAATTLSSSILARYHEEQIWSDKIRRMSTWGTWGLMGVNVLLFLVFQLGFEPWRRQRLVHGFEEKVLEALELERAKQASPKDKDDKVDIALDSVVATGAEELQNEVAAGNKGAEPAVDAIVACIEGDTSEAEKLAEPVKESGTTDVPTLLMKLRKPETWKTAVEDLFSERIVSMRKQDVTVVALEGAAAGAMLAGIIATTLLRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="25" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S388</accession>
    <name>A0A3D8S388_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glucan 1,4-alpha-glucosidase</fullName>
            <ecNumber evidence="3">3.2.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">1,4-alpha-D-glucan glucohydrolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Glucan 1,4-alpha-glucosidase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">BP5796_05259</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16 17">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of terminal (1-&gt;4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose.</text>
            <dbReference type="EC" id="3.2.1.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.3" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S388"/>
    <dbReference type="OrthoDB" id="6123450at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000324">
        <property type="term" value="C:fungal-type vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004339">
        <property type="term" value="F:glucan 1,4-alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000272">
        <property type="term" value="P:polysaccharide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.10.10:FF:000018">
        <property type="entry name" value="Glucoamylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012341">
        <property type="entry name" value="6hp_glycosidase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011613">
        <property type="entry name" value="GH15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000165">
        <property type="entry name" value="Glucoamylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046966">
        <property type="entry name" value="Glucoamylase_active_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008291">
        <property type="entry name" value="Glucoamylase_SBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616:SF12">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31616">
        <property type="entry name" value="TREHALASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00723">
        <property type="entry name" value="Glyco_hydro_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001031">
        <property type="entry name" value="Glu-a-glcsd_SBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00736">
        <property type="entry name" value="GLHYDRLASE15"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00820">
        <property type="entry name" value="GLUCOAMYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0624">Polysaccharide degradation</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="GH15-like" evidence="15">
        <location>
            <begin position="43"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="502"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="510"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="206"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001863"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00033442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR001031-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR001031-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="RDW80561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="549" mass="58033" checksum="7B2D57375DD35F63" modified="2019-01-16" version="1">MLWERVASTAAGVLSAARNLGHPVISARATGTLDSYLSTESPIALQGVLNNIGPNGIKAPGADAGVVVASPSTVNPNYFYTWTRDSALTFKYLIDTGNSSLQTLIEDYVIAQAKLQTVDNPSGNLASGAGLAEPKYYTNETAFLGEWGRPQRDGPALRATALMAFANDRLALGQNSTVKDIIWPIVKNDLTYVAQYWNLSGYDLWEEVNGSSYFTSAVQHRALVEGASFATSIGETCTECESEAPNLLCFMQDYWNGSAIISNIDVQQSNFNRGGLDCASILASIHTFDPDSAIGCDSATFQPCSERALSNHKVVVDSFRSIYTVNANATTGKAAAIGRYEEDVYQGGNPWYICTYSAAEQLYDALHTFNAVGSITVSDISKGFFTDLVPGIATGTYSSSSAEYSSISTAMKTYADEFVAIAQQYTPSDGGLAEQFSRENGTALSAVDLTWSYASFLTMQRAREGNVGSSWGAANAKTVPSTCSKGSGVVGTYATPTATVFPQSEEGTFGSNSSTNGSSATGTGTATGSAASATKSKSAGNRLSPFPWM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="6" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S3X7</accession>
    <name>A0A3D8S3X7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_05499</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S3X7"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW80801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="147" mass="16465" checksum="BBC8C930DBB1121A" modified="2019-01-16" version="1">MWELCAGPVGTSVRASALRVPRRAPRLVQLSQHRIAPPVVVGPCDRTLDLSTARNRCCEEIHAIDPWLSTANFACDVDAARAFLKAKEAAMVERRKSQDSGERHRTVAVGMGTWRLRSARSRRQPSTEQDNHWVFTSLNDTLMATQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8S480</accession>
    <name>A0A3D8S480_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_05599</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000007">
        <property type="protein sequence ID" value="RDW80901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8S480"/>
    <dbReference type="OrthoDB" id="103819at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050987">
        <property type="entry name" value="AtrR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910">
        <property type="entry name" value="TRANSCRIPTION FACTOR PDR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46910:SF5">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="21"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW80901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="713" mass="78482" checksum="4D68A772BC63BC73" modified="2019-01-16" version="1">MEAAKNNESGGDGPASLMKNACDACRARKVRCDRANPCSNCVAIKGACRFSPKHNDNRQRILISSRYENKVESIDERLAGIEKSLQTLILNMKTTPAQSAAVDGPTPLIKPALNSSTLSRTPKDRLDVTETFEGGTSLKAHSLHAKGLFETLSSSTSAKRSALLRDALTSLQNTLKAESDPAMFYDLRFTSEREMKFTSISDLEMPPMQDVLEVLRAANEKLPHMFLEAPVFEVTQFSEMCKNLYFCTTDYSPALFAIVNAGLAHLFAQGAFEKEGSTATEWQRYAYICGLNFELTMENLTIFLAPSLESCQALICGAYYACEIAKASLCQRLTTIAAQMCQALGYHRLPATKVETKELRAKKTAFWGVYALDKALSLRLGCTSVLQDDDISTTVPSYPEDPTLHSWHTMFIAWINFARFQGQAYSLLYTAKALNAPLSEKLSRIKRLAAEIQDWREGVTEMKEGNTLYPEIFEMNRESMDVVAWGVLSIIYRAVPPSVSDISSNFNTECISAARKALDLHRAAASRFHDNNAIWQGYVNWTLLFSPFAPFMIVFCEAVTTLNLVDLSCLAEFVSSIAPNEETINKGARRLFHLCSAFYQVAKIYIEESLDSASKVPIDSTNAVSVAVSDQNTSFLAPQPQRGYAGYDTAGSSWQQGLSGMDGLGDSTANGPDGFLGVSGVDNYMGWSTEDWSMPDMYMMGIIDGSIRGGPSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SA08</accession>
    <name>A0A3D8SA08_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">AMP-dependent synthetase/ligase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_04677</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SA08"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="66"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW83186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="709" mass="77380" checksum="231F9FC9B6C7D2A0" modified="2019-01-16" version="1">MAPVIQDPQAYVQSLRVPPPPGAPHSVALPGSEREGRSAVYRHWRFADGPLLQTVDPAVLTAHDMFESSAKNRPNARCLGNRPWDPVTKTFGKYEWMTYKETADRRRNFGIGVVELHKKAGVTGSKYGVGLWCQNRPEWQITDLGCMSQSLFTVSIYDTLGPETTEYIINHATLACVVTSLLHVPTLLKLAAASRLPTLKLIICLDALEAGEVPGNSKKDILNTLAADAGISIYGIGEVEAIGAAAPSISMNPPSPEDIITINYTSGTTGNPKGVILTHANAVAAASTARVTSDTTPNDVLCSYLPLAHIYQRVAEHGSLFVGSAIGYFHGDILGLVDDLKLLRPTGFNSVPRLYNRFGSVLKAATVDAPGLKGAIGRHVINGKLAAMKLPPGQASNKHAIYDRIYTPKITSAFGLQRARGMVTGSAPIDPSLHQFLRAAFGNDFIQGYGLTETYAVSLAQFRNDYSSGNCGGLAVTMEACLQSVPSMEYNVTDSPNPRGELLLRGNTRFREYFRNPEETSKAIDQDGWFRTGDIAEVDSLGRFKIIDRVKNVLKLAQGEYVSPERIENVYLANCNLLATAYVHGDSTQAFLVAVFGVDPVNFAPFASNILKKKIEPADIEAIKAAGKDDRVRKAVIKELDKIGKKSKFNGWERVRACHLEVEPFSIANELLTPTLKLKRPQTAKKFRDHLDRMYEESLAEEKAVKAKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SAU5</accession>
    <name>A0A3D8SAU5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_04389</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion inner membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the complex I NDUFB7 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW82898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SAU5"/>
    <dbReference type="OrthoDB" id="268414at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008698">
        <property type="entry name" value="NDUB7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900:SF0">
        <property type="entry name" value="NADH DEHYDROGENASE [UBIQUINONE] 1 BETA SUBCOMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20900">
        <property type="entry name" value="NADH:UBIQUINONE OXIDOREDUCTASE B18-LIKE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05676">
        <property type="entry name" value="NDUF_B7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51808">
        <property type="entry name" value="CHCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="9" id="KW-0249">Electron transport</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW82898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="94" mass="10587" checksum="97329AFCC86AB777" modified="2019-01-16" version="1">MTVVETVKAAVGLGDSPAPASRAAMSEASLPLAYRDSCANLLIPLNKCRKEEYYLPWKCETERHSYEKCQYEEFKKRVAKMDELRAAKDGARSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="12" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SBJ5</accession>
    <name>A0A3D8SBJ5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF952 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">BP5796_04619</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1 2">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000006">
        <property type="protein sequence ID" value="RDW83128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SBJ5"/>
    <dbReference type="OrthoDB" id="3335358at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.20">
        <property type="entry name" value="Protein of unknown function DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009297">
        <property type="entry name" value="DUF952"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34129">
        <property type="entry name" value="BLR1139 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34129:SF1">
        <property type="entry name" value="DUF952 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06108">
        <property type="entry name" value="DUF952"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="RDW83128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="14526" checksum="31369B756923A5C2" modified="2019-01-16" version="1">MTSSDPPMPPHIYKILPSAPGSPIPAALAASDLDRTDGFIHTSTAAVVPTTSRLFFHAAPELWILKLSTAQLARDGARCLWEGPQGCVHVYAADAGLVSLGAANVLDVMRFVRRGEEAWDEVFGREDARAWLVDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SGI5</accession>
    <name>A0A3D8SGI5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Rhodopsin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_03780</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the SAT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SGI5"/>
    <dbReference type="OrthoDB" id="5417887at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049326">
        <property type="entry name" value="Rhodopsin_dom_fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052337">
        <property type="entry name" value="SAT4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048:SF42">
        <property type="entry name" value="INTEGRAL MEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33048">
        <property type="entry name" value="PTH11-LIKE INTEGRAL MEMBRANE PROTEIN (AFU_ORTHOLOGUE AFUA_5G11245)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20684">
        <property type="entry name" value="Fung_rhodopsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="202"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodopsin" evidence="7">
        <location>
            <begin position="36"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF20684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW85455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="367" mass="40202" checksum="33F9BE3E200DB7FC" modified="2019-01-16" version="1">MAEFMGPVPTGDWGVATTVIASIWAMLIVTTMFLVLRLYCRAIRTRTLWWDDYLLIASWVSLLASTSLLTRVFHLGYTTTTFGSNTISPMNFAADDMHKLALGLSKTSFALTLLRFTSGWSKHLIIVLTVVMNVVFLAHCVLVWRASCGGESSFNFTPCWPASSGAYMNMIGSAFSAASDFILALLPIKVIMGLQMARNEKIGVVIATSIGVLAGAVAVVKSIKSLTISNIFDPQFGHNLAVLSIWIEAEPNATIIAASIPILRILFRDFQRYVTNSPSAGSYLKSNQRSGFHTHVSARDDTKVDATVIVQDNESETGILSNKNRFNDGIRTTREVMIGYDAGDDHQVGGHQGIELQARIPVFRLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHD1</accession>
    <name>A0A3D8SHD1_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Elongin-C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">BP5796_04055</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7 8">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Controls sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SKP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHD1"/>
    <dbReference type="OrthoDB" id="249087at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18321">
        <property type="entry name" value="BTB_POZ_EloC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000035">
        <property type="entry name" value="Elongin C transcription elongation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039948">
        <property type="entry name" value="ELC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20648">
        <property type="entry name" value="ELONGIN-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="6">
        <location>
            <begin position="9"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="RDW85730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="102" mass="11346" checksum="C3072B40EE08A5A4" modified="2019-01-16" version="1">MATPSQSKYVTLVSNDGFEFVVLREAACVSGVIKRSLDPKSGFAESAAGRVTFDEINGIVLEKVAEYFNYNHKNRNREDVPDMEIPPELCLELLMAADFLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHG3</accession>
    <name>A0A3D8SHG3_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase component-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_04114</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>(R)-lipoate</name>
            <dbReference type="ChEBI" id="CHEBI:83088"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 2-oxoacid dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHG3"/>
    <dbReference type="OrthoDB" id="15567at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016407">
        <property type="term" value="F:acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031405">
        <property type="term" value="F:lipoic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.559.10:FF:000007">
        <property type="entry name" value="Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.320.10">
        <property type="entry name" value="E3-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001078">
        <property type="entry name" value="2-oxoacid_DH_actylTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050743">
        <property type="entry name" value="2-oxoacid_DH_E2_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036625">
        <property type="entry name" value="E3-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004167">
        <property type="entry name" value="PSBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178">
        <property type="entry name" value="DIHYDROLIPOAMIDE ACETYLTRANSFERASE COMPONENT OF PYRUVATE DEHYDROGENASE COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43178:SF5">
        <property type="entry name" value="LIPOAMIDE ACYLTRANSFERASE COMPONENT OF BRANCHED-CHAIN ALPHA-KETO ACID DEHYDROGENASE COMPLEX, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00198">
        <property type="entry name" value="2-oxoacid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02817">
        <property type="entry name" value="E3_binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47005">
        <property type="entry name" value="Peripheral subunit-binding domain of 2-oxo acid dehydrogenase complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51826">
        <property type="entry name" value="PSBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0450">Lipoyl</keyword>
    <keyword evidence="8" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Peripheral subunit-binding (PSBD)" evidence="7">
        <location>
            <begin position="41"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="88"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW85789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="346" mass="37162" checksum="AB887BF88098E97E" modified="2019-01-16" version="1">MPDEGEQSESQSSFDPSPTHARDNSSMPTESASPKSKHASLATPAVRHLSKELKVDITEIDGTGKDGRVSKDDVYRFARQRDSIPDVSSPAPAYSTPSTSSGAQQESITQLTTTQAQMFKTMTRSLAIPHFLYADEVDFSGLSDVRRRLNLGLTKSPANEVTKLSYLPFVIKAVSMALQEYPTLNARVDVEPSCSSKPVLVMRSQHNIGVAMDTPSGLLVPVIKSVASRNILSIAAELSRLQVLASSGKLTTQDLSGGTITVSNIGSIGGTYVSPVIVDKEVAILGIGRIRKIPAFGEDGQLVEKQVCNFSWSADHRVIDGATMARAAEVVRGFVENPDSMVLRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="16" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHG5</accession>
    <name>A0A3D8SHG5_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein Zds1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_04068</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHG5"/>
    <dbReference type="OrthoDB" id="5589766at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030010">
        <property type="term" value="P:establishment of cell polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010971">
        <property type="term" value="P:positive regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040206">
        <property type="entry name" value="Zds1/2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013941">
        <property type="entry name" value="ZDS1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28089:SF1">
        <property type="entry name" value="PROTEIN ZDS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08632">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01327">
        <property type="entry name" value="Zds_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein Zds1 C-terminal" evidence="2">
        <location>
            <begin position="754"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="256"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="342"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="812"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="864"/>
            <end position="942"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="94"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="372"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="407"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="508"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="539"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="563"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="636"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="822"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="882"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="899"/>
            <end position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW85743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="942" mass="105180" checksum="771A94776B5D35D9" modified="2019-01-16" version="1">MLRRVLNLDPSRPFTDTTFLLQTSSRPREVGGSFASRRGHANQLSISDTNHHVTEAIGDMYGDDDFDSKRDSRPLSFIASPLQETHHGMTDEGSSYFESSRSNRSRPPLSPNSANGMKAKSSPALMSNQRSGSFEGSNGPLSPTLSLRERASSDTANQQFPLNDIDYESDPTAIAQELNNLQALRRMSMDVGNTSDPDLPSFQGVSLMPSVAPPTGAEDEDDPSRLFWVPAKVHPELAPMEFKKFLENRVQSIKRRSGEQATLSPDGLDRSGSSGGLRRKKSMLSRQIDNSGGRGAVGYKDGAEQLERKKSLSHNVKPELKISDLQELDALVKDPTRAMQKLKLDTGRESPEMDMGEDMPILPAAPGIGLRRSTRTTYRKGSLRKGERVPFSKRAGSIRAEAEAEDSPSSSPVDSRSSSERPAIGYPLTKVQSEPTTTENFSRPNRGARRGQNLQEISPITYSDDSMLDDVLAKSTEELVARAAREAPDRPIQAGPPPRSNTFPRNNTPVPQIIETPPTEEVPEVKPAPQFPERSSSQIPPPQANAPPIEPPARSSKRPNLDRQASSNAQSIPKASNPSQTLNEMAQQPSPLMGNNGRTDSLTFVPFEEKKPEKKLKKEKDEEGGSRKPSWGWFKGSEEKEKKNKKKDEEPKGKKGVVEKAHDATRLDVIQSSIETGISRGRESLLLDRESIDNKLQDERKKESSRKSTDGKKEKDGLFSSFFGGGKKKAERDSGGKKGGSLRTLSPEPPPRQLKPDIDYNWTRFSILEERAIYRMAHIKLANPRRALYSQVLLSNFMYSYLAKVQQMHPHMQVPQSAQQKKAAEAERKAKEEQQRREQEQQQQQHNGEEQYRYDYHQGITQYAEPSSHKSEGVDYVDDSQIYDHDHQEEDYSHGQGSGRPQSRASHNTENGYGDQNQHYRSQQNDYYSYGGQHDDDDDDDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SHM8</accession>
    <name>A0A3D8SHM8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Glutamine amidotransferase type-2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">BP5796_04128</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6 7">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SHM8"/>
    <dbReference type="OrthoDB" id="10252281at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03766">
        <property type="entry name" value="Gn_AT_II_novel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051857">
        <property type="entry name" value="Asn_synthetase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937:SF1">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00733">
        <property type="entry name" value="Asn_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13537">
        <property type="entry name" value="GATase_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="5">
        <location>
            <begin position="2"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="RDW85803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="587" mass="65265" checksum="78ED6E7254FA27B8" modified="2019-01-16" version="1">MCGIHLSISTTGTQPPSHRLRELLCKRGPDHLGDVGAEVHIPYVAPLFLHFTSTVLALRGTPGEQRHGHDSITRQPFHDTGSGSILCWNGEAWRINQRPLVGDNDGQIIFTMLLKASTSSLSDYESKRAVLQVLKDISGPFAFVYFDKAHNVLYFGRDRLGRRSLLYNTDSSSQALELASIADPSRGLWKEVDADAIHMTSFAANQSQEGIASNIDCTTPQFTCPIGRELWDQAPGLGSFNRNITSGIQPLQLQSSSVAILRQHLVDSLRLRTLNVLVPPSLCMASRVRIAVLFSGGLDCTVLARLTHELLPLDQEIDLLNVAFENPRVVQAAKNARKPGQPQANTLDPFESCPDRQTGRRSFQELQDVCPTRFWRFVAVNVPFEELKLHKPEVIDLIRPHNTEMDLSIAYALYFAARGKGVSYVGPSHYESETYTTSARVLLSGLGADELFGGYTRHATAFERRGYSGLLDELELDINRLGKRNLGRDDRVISHWGREARFPFLDENLVKWAIEAPIWEKCGFMPGLKDVVDGTDFALDPSKKVLRLLAFKLGLDSVSKEKKRAIQFGARTAKMETGRTKGTSLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SIM2</accession>
    <name>A0A3D8SIM2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Rad4-domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_03963</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000005">
        <property type="protein sequence ID" value="RDW85638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SIM2"/>
    <dbReference type="OrthoDB" id="300780at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.2460:FF:000001">
        <property type="entry name" value="DNA repair protein Rad4 family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.110">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.290">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018327">
        <property type="entry name" value="BHD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10404">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01031">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="7">
        <location>
            <begin position="564"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="8">
        <location>
            <begin position="629"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="9">
        <location>
            <begin position="693"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="85"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="365"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="808"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="827"/>
            <end position="836"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW85638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="852" mass="95998" checksum="F9F565F9BD91B611" modified="2019-01-16" version="1">MPPKSRDRRKGQNGPDISTEEIIGSIGFVDLEDTSDSPAGRMRTRRRASARQPTTRRAPIPDVYQDMLAEVLPAQSDVFERLLKRRKTGKGKEVTSSPAHSTENGDEEVDAEDEDVQFEDVLDIPEIKASRNASGSDDDEPEAKQQQTAYRDSEGDDDSAEEGFDWDALQSRSRFQDGPKDLELTLIKKTLPDQKTLPSRRKVTTQAEKNLRLEIHRMHLLCLLAHVNIRNSWCNDAEVHAALKPMISKKALAYLRPKSDLSQFGRIESLKRGLEQVGNMWKIQYKITKRGLRRSLWAEDEEHIQNYELPADAEPATERSDFRTAAKTLNGSRDLGIQLFCALLRSAGVETRLTCSLQPLTFAGSGPSMPRSAPRVTKVPSPESSNEEDAIDLHGSSSPFRSNGGQGPAVPIPARRRLGHPHAAAYHLPDMAAPPRAPPKPKTKPIYESPYPVYWVEVLDEAHQKWFPVDPLVTDTMSKPRAFEPPAADRENNMSYVVAFEEDGCARDVTRRYAKTYNAKTRKNRVESIKGGEKWWRRTMRAYSRGWQSDLDQIEDTELSQAEAREPMPKNVADFKDHPYYALERHLKRNEILTSTREVGKVAAGKDTSGPPGRKKLESIYRRRDVKIAKSADAWYRLGREVKIGEQPVKVVPARRTNDEDIGDDAEEGAGTNLYTEDQTALYESPPIVNGRVPKNSFGNLDIYVPSMVPKGGVHIHYPEASRAARLLGIDYADALTGFEFRGRHGTAILKGIVVATEYYEGIEAVIQGFRDEEARAQEEMRTITVLKFWKRFLVSLRIKERIDTYDIEGEDPPVGDLPSQPHKDIPDEEDEVIQSDDSRYEDDYGGGFIPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SLY2</accession>
    <name>A0A3D8SLY2_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">BP5796_03021</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4 5">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SLY2"/>
    <dbReference type="OrthoDB" id="3251668at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021858">
        <property type="entry name" value="Fun_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR PROTEIN UGA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37534:SF46">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11951">
        <property type="entry name" value="Fungal_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="3">
        <location>
            <begin position="10"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="RDW87327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="446" mass="49880" checksum="0DEE4093179B1B21" modified="2019-01-16" version="1">MPRVRTIEGSCWACKERRVICDLTHPTCNKCASSGRSCDYGRVRLKWTDCIASRGRLAGQKIPLDRPLMVRRNSDHHLMYFENELLPRFNLSNTIPRFSLASLAGDPLVLQSVIAIGAAHSSYRSASSDPATSLTKSQDRSSAIRIFRENLSGKQSEEVHNSLFMANVLLCMLDGIIDQQSTQDAATHHHILGGKAILNQWGGAPGILQTKKDLPVLMFSIFATMDLTHALLMGGQPFVESTSWVDFADAEPWWGNVKADNEFLAMMAILSQLATLGHSVHNLHEVVPIGTLLSIQKSLEHHATRQSHQEQDPSGLSWASFCTVYRCTAYVYLYRALSGLDIDHPLVQQAVTTAMEIVAGTLLTENLHHCLLFPLLTIGSHCMSEKQRQEIRRRLATSAQFLSFGSLRNLDDFLQRTWARIDRDPNYLAVSWWSLFDEIASATCLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="20" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SM26</accession>
    <name>A0A3D8SM26_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">BP5796_03016</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8 9">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SM26"/>
    <dbReference type="OrthoDB" id="4139357at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17502">
        <property type="entry name" value="MFS_Azr1_MDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000196">
        <property type="entry name" value="MFS toxin efflux pump (AflT)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1720.10">
        <property type="entry name" value="Multidrug resistance protein D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23501:SF158">
        <property type="entry name" value="TRANSPORTER, PUTATIVE (AFU_ORTHOLOGUE AFUA_5G14490)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01036">
        <property type="entry name" value="TCRTETB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="327"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="454"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="535"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="67"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="564"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="564"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="RDW87322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="583" mass="62156" checksum="6DE4099EE91B6957" modified="2019-01-16" version="1">MSSSNPTSDCHVVVDGDAISLIILPSAVHPGPQEELTIHSSLEARDHGVENAAGSSSVRSRIQLTATLLALFLSLFLAALDFTIATTATPTIINELHSATAYTWIGSAYLLASAASTPVLAKFSDIFGRKNILLVAVAIFFAGSAICASSNTTTSFIAGRSVQGSGAGGMIILTNICISDLFSMRDRGLFLGLTGVVWSLASGVGPLLGGALTEYVSWRWNWWINLPISGFAFGVLYFSLHVHNPRTSFLKGAKAIDWLGTVLILGLTLMILLGLSLGGIISPWGSPKVICLIVFGLVIVFVFGIHETRFATNPLMPMRIVQRRSNVASLLVCFMHGFVNMSSWYFLPLYFQAVKEASPLRSGLLILPITLVQAVVSVAAGCFIRYTGRYLELIWIGMAGTCLGFGLFIKLGVNSSLVEIVLFQIVAGVGVGLVFQPPLIALQSLVAQEDVAAATALFGFSRSFSTAVSAVIGGVIFQNQMQAHYNELQFILPGDVARNFSGHAAAANVKLIATLTVAEKIAVQKSYAESLSTMWILYSSIAGLGLLLSVFITKQNLTTEHVETRTGIEKDEQGKAPEAVVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="18" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SM63</accession>
    <name>A0A3D8SM63_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Low temperature requirement a protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_03060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SM63"/>
    <dbReference type="OrthoDB" id="191995at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010640">
        <property type="entry name" value="Low_temperature_requirement_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840">
        <property type="entry name" value="BLL5714 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36840:SF1">
        <property type="entry name" value="BLL5714 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06772">
        <property type="entry name" value="LtrA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="267"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="349"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="470"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="521"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="561"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="583"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW87366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="658" mass="73775" checksum="B3669EC3CF5B6530" modified="2019-01-16" version="1">MSPILVSAGGTTSPHTRGSHHGGCRLRHFVLPDGKNVHIALSPEEADSLRERLKVVSDDEPFDLVINGSPEHLDALRIAHDHHEKKCDTLKQTHGPTYDEIENTRSQKDAFAQELHTLAHQAVSLDANFSKYGYSAELRTFDDASALASSRSSIGGFHDDNHEKKDWAAERRNGRVMKLYKKPVVRQYFHRGLLWRGSGIVEVASFELFIDLLYVGILAINGDHVAEDTTGYELLRFSITFIMSWTIWNDLVVIVSCFETDDVLQRVSVLFVMACLLGLTTNMLDALGETYFQLVTFYLAARLFLGVYYLVFAISVPIVRGVMMFQSFVTVLPSVLWIASIHVELPHRLALIWIALFLDICAPWTIFIVIPGARSVSKRFEDWVKRAFEFYPTINIEHKVERTNAFVTLVFGYAVVSIIYQSSARFGVNAFYGKAVLGLIQSFCMNWIYFELDGTDLFAHAIRRSVVRAWIWNLAHLPFIMSFALGAAALSKLVVATDCPNATLDSLTAVYVEKSEHEIPIGLRWFYCAGLGIALLFMGIISISHIHKEIGGSRLLKRHRLANRFTICVILVCLPLAHGLNSLQLISTVTGLVVWVLFFDLWGASSPKESFFGEKSSCSYTAHCKVPRKDLESAVKGGQTINIKSVSNQGEKATYEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="21" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SN98</accession>
    <name>A0A3D8SN98_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GPI-anchored wall transfer protein</fullName>
            <ecNumber evidence="9">2.3.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">BP5796_03503</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10 11">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">A acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 9">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Endoplasmic reticulum membrane</location>
            <topology evidence="2 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 9">Belongs to the PIGW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.-.-" evidence="9"/>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SN98"/>
    <dbReference type="OrthoDB" id="15270at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032216">
        <property type="term" value="F:glucosaminyl-phosphatidylinositol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072659">
        <property type="term" value="P:protein localization to plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009447">
        <property type="entry name" value="PIGW/GWT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20661:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS W PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06423">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017321">
        <property type="entry name" value="GWT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 9" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="32"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="87"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="211"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="312"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="353"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="389"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="444"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU280819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="RDW87809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="498" mass="54706" checksum="0A846B27D756BB6B" modified="2019-01-16" version="1">MSRSLEESMAASYKSLKEDFVSNLAGGEIGEINYVTAVAPVAVILWSVLQTRQSLFTVYTPIAFLVDFFLNVGAILLATTLYADSPLLLNLLLIAPAVLVYALPSNNPHKKKAKPPGLAPTKGASSLSPLPKKPFLTTYRGCMMAITCLAILAVDFRIFPRRFAKVETWGTSLMDVGVGSFVFSAGVVAARPILKEQLANKTSRLSTRLYASVRHSLPLIVLGLIRLYSVKGLDYAEHVTEYGVHWNFFFTLGFLPPFVAIFQSAFQLLPSYEGLAVLLGIAYQIALEFTNLKAFILTAPRTDLLSQNREGIFSFFGYLAIFLAGQGTGMYIIPREMTKTIRTGPEHRQRLLITLAAWSLCWIVLFCLVTNYSYGFGLSVSRRLANLPYFLWISAFNCTQILAFCVVETVFFPAAHRSIDTKAEHDAYQSSTSKVLEAFNRNGLAVFLVANLLTGLVNLTVPTLHVNNIQAMGLLMAYAITLTGLAVGLDGYGISIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="17" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SNG8</accession>
    <name>A0A3D8SNG8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Major facilitator superfamily (MFS) profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">BP5796_03541</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11 12">BP5796</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SNG8"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000023">
        <property type="term" value="P:maltose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1250.20:FF:000078">
        <property type="entry name" value="MFS maltose transporter, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005829">
        <property type="entry name" value="Sugar_transporter_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00879">
        <property type="entry name" value="SP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF5">
        <property type="entry name" value="ALPHA-GLUCOSIDES PERMEASE MPH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00216">
        <property type="entry name" value="SUGAR_TRANSPORT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0462">Maltose metabolism</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="105"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="226"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="312"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="405"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="439"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="473"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="10">
        <location>
            <begin position="56"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003346"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="RDW87847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="539" mass="58761" checksum="EE831386B0949D21" modified="2019-01-16" version="1">MMSNTVILSEKIEDDYMVEAVEDGFFNQKGPTVEPSSGNTNATLKDIWTHRRVLLWCILVYLLPINFGYEGGMVGNLLAVDSFLERFGHALPSGQLEIAASSQQILNAGTTIGIFCSAFGTGFLSDIFGRRIVVLAACIICLAGTLVQYYSTTIIMLFGGKLIVTFGFGLGHSLGPVFVAELAPTVLRGTCLSLVNTMIVIGHWTSSLCVYGSSNLSGDASWRVPVITQVIPPCLLLLLGAPLLPESPCWLLMKGKREQAIKSFKPFNGQDFDAERAVQTLEYTLETEKAMAAEGSSYLECFKGTSLRRTTIICMVYIAQQFIGVNFIAGYLPYYFTLAGVQNALAIAQVAYAIQLFGNLCSWSLIDRYGRRTLVVYGTIVMTASLLIIGGISTINSSNSLKATVALMCIWGFIYQATLGPAAYAVGGETSTPRLRQKTYAINIMSATAVSCMGLQVTPFLINPGNANLGGKITLVFFFPPSVLVCIYLYFCFPEMKDRTYLELEEMFQARVPSRKFKSYVCQSTTMATDEPSAGDEKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="13" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SNU7</accession>
    <name>A0A3D8SNU7_9HELO</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_03162</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000004">
        <property type="protein sequence ID" value="RDW87468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SNU7"/>
    <dbReference type="OrthoDB" id="10039566at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000329">
        <property type="term" value="C:fungal-type vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022185">
        <property type="entry name" value="DUF3712"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046368">
        <property type="entry name" value="Tag1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895">
        <property type="entry name" value="CHROMOSOME 16, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35895:SF1">
        <property type="entry name" value="LIPID-BINDING SERUM GLYCOPROTEIN C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12505">
        <property type="entry name" value="DUF3712"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW87468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="335" mass="36064" checksum="5443AF4DE5E7D01F" modified="2019-01-16" version="1">MSEKVDTTYLENRYNEPAPRPGVGQKAKRHCARWWWLHLIIFCVVFLIIALCLVYAAMPHIAQHDVNKSTLTFTELDFLEPTADSVTITQKGILHSYSMYTPTLDPFTASSWLVTNGTFGANPILTVEMPKIHAMHGDNNVSVSSQVASVVDTNQLNAFTIAALNQEYITTALTGKTKLHEGALPVTTVSYNKSTTYKGLNRLAGFNVTSPKINLTATTGTPNFIGFAFIPNPSIMTFAMGNVTLSLATAQAGVLGNATVENMTLVPGNNSLPMTAIIDQLAVLGSMDKSGNVLLQITGTSAVYNGVHLTYYEAALKSNVLSLEMNIAAILTGSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SXJ6</accession>
    <name>A0A3D8SXJ6_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tafazzin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">BP5796_02200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2 3">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SXJ6"/>
    <dbReference type="OrthoDB" id="5278911at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="RDW91035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="484" mass="54288" checksum="FB5F0E78C713969D" modified="2019-01-16" version="1">MPKKRFTSQYSKPQSTVHPSLGSGFAVPASSSHATPSVNELISSLRKTQISTSEDQTRFSATVVTPTLPPSIRTLLAIPDTPPPRLRDRNRRRYDENGRRIPAGPAPPRSWLETSQHAPVAVRKVEYGRLYPHNVEHLPGVVAPVVGSLQDHCLKSMARNWLFIREYETYNLSDLPTRIRVLLLSYIAVYGSDQGIGYTGLKSILTPPPLDEDEEEELETDTAGSERNENLQRLDLSGSVGRSVSLKQLSELLIRRSAAIENESWEESIPTPMGPVLPHLTHLSLAYPPGNISWPKLLSFAQHVPTLTHLSLAHWPVPNLTPNSRTTVMSSPHLRDVQYGGTNYYSHTLDGDFAEASVILKRLANFLYSLKWLDVTGCSTWLKAMQYGSVEESHLEWSTQWLSLDVLIANTGYELEDGCQNSDIEAFRTAWQETMDLKSHILTTRKKAGRKSWIDVQAEKDSHKWCHLWTGPSEHQCHAQGHSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="22" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SY80</accession>
    <name>A0A3D8SY80_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_02438</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="5"/>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SY80"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000029">
        <property type="entry name" value="peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000009">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0697">Rotamase</keyword>
    <keyword evidence="8" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="12">
        <location>
            <begin position="12"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="181"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW91273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="371" mass="40150" checksum="3E995277FE2A4483" modified="2019-01-16" version="1">MAESKAQRSRVYFDISIGSKPAGRITFELYDDIVPKTALNFKCLCTGEKGVGKAGKPLCYKGSIFHRVIKQFMCQGGDFTAGNGTGGESIYGEKFADENFEIKHEKPFLLSMANAGPGTNGSQFFITTVPTPHLDGKHVVFGEVLSGKSLVRKIENLPTQAGDKPIKDVEITDCGELTGAEAEAATQKAPDSTGDPYEDFPEDNNNPEPSAKEIIKIAADLKGFGNTAFKAGNLELGLEKYQKGIRYLNEDPELKNEPASTKTELDTLRFTLNSNSALLANKLQNYDEALKYASAALDVASIGDADKAKALYRRAIASIGLRDEESALKDLEQANKLVPGDAAITKELNTVKKVAADRAKKEKAAYSKFFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="26" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYE0</accession>
    <name>A0A3D8SYE0_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Asparaginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">BP5796_02445</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13 14">BP5796</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Asn) + L-asparagine + ATP = L-asparaginyl-tRNA(Asn) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11180"/>
            <dbReference type="Rhea" id="RHEA-COMP:9659"/>
            <dbReference type="Rhea" id="RHEA-COMP:9674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58048"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78515"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.22"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="3"/>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYE0"/>
    <dbReference type="OrthoDB" id="1931232at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF16">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="1"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="RDW91280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="304" mass="34718" checksum="415E82B37721EF7B" modified="2019-01-16" version="1">MKARAAALTAFRQYYKDNDMRESTAPTFVQTQAEGGGSLFSLPYYGERAYLTQTSQLYLETQLPVLGDCYTIQSSYRAENFHTRRHLSEYTHIEGEIDFIVFEDLLQHIEDVLCGVIDILLADEESAACIRTLNPDFKAPTRPFRRMRYSEAIGWLNEHNITTDEGEPHTSGMDIAEAAERAMTDQIGVPIMLTHFPVPIKPFYMKRDESDPRVTESVDCLIPGVGEVVGSGMRMEYYDDLLTVMKENKMDLASYAFYLDQRKYGTSSHGGYGMGLERILAWILRRHTVRECVPFPRYPGRCTP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2025-10-08" version="14" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SYU8</accession>
    <name>A0A3D8SYU8_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RGS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">BP5796_02650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3 4">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SYU8"/>
    <dbReference type="OrthoDB" id="10266999at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="CDD" id="cd07440">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.167.10">
        <property type="entry name" value="Regulator of G-protein Signalling 4, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016137">
        <property type="entry name" value="RGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036305">
        <property type="entry name" value="RGS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044926">
        <property type="entry name" value="RGS_subdomain_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10845:SF267">
        <property type="entry name" value="REGULATOR OF G PROTEIN SIGNALING DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_6G06860)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00615">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00315">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48097">
        <property type="entry name" value="Regulator of G-protein signaling, RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50132">
        <property type="entry name" value="RGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RGS" evidence="2">
        <location>
            <begin position="45"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="168"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="233"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="328"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="RDW91485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000256328"/>
        </source>
    </evidence>
    <sequence length="351" mass="37951" checksum="6183F94E60D55052" modified="2019-01-16" version="1">MSSGEFLPSRPLSLAIPAGPYCPRRPTLEEVLSNNAPPPWTLSAFMAYLSQNHCLETLEFTMDASRYTKHYHSMVDSDPHMPLSPKTQGCEYVRMLWQKLLDAYIAPNGPREVNLPSDVRDRLMALPCTYTPPHPSALDRAVKIIYELMDESVLVPFLNSVVSARGPDTYTTPWNSDENMVDTKMTGSLDERSLSPARSRNKKDKSPRIGFADEPMSQSFTGPSPRFSHHSHLSAALSRGSSRLSTHLTGSSAASAEATDSLTDDSTDSAVSPSGSALEPMTPPTTPPTSDTGFSNMSPSTSPKTARGEGSGWKKMGAKLGWKKSRSAHSSTSSTSGARPPVMSEGTEVAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2019-01-16" modified="2026-01-28" version="28" xmlns="https://uniprot.org/uniprot">
    <accession>A0A3D8SZ91</accession>
    <name>A0A3D8SZ91_9HELO</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Zn(2)-C6 fungal-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">BP5796_02781</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Coleophoma crateriformis</name>
        <dbReference type="NCBI Taxonomy" id="565419"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Fungi</taxon>
            <taxon>Dikarya</taxon>
            <taxon>Ascomycota</taxon>
            <taxon>Pezizomycotina</taxon>
            <taxon>Leotiomycetes</taxon>
            <taxon>Helotiales</taxon>
            <taxon>Dermateaceae</taxon>
            <taxon>Coleophoma</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2018" name="IMA Fungus" volume="9" first="199" last="223">
            <title>IMA Genome-F 9: Draft genome sequence of Annulohypoxylon stygium, Aspergillus mulundensis, Berkeleyomyces basicola (syn. Thielaviopsis basicola), Ceratocystis smalleyi, two Cercospora beticola strains, Coleophoma cylindrospora, Fusarium fracticaudum, Phialophora cf. hyalina, and Morchella septimelata.</title>
            <authorList>
                <person name="Wingfield B.D."/>
                <person name="Bills G.F."/>
                <person name="Dong Y."/>
                <person name="Huang W."/>
                <person name="Nel W.J."/>
                <person name="Swalarsk-Parry B.S."/>
                <person name="Vaghefi N."/>
                <person name="Wilken P.M."/>
                <person name="An Z."/>
                <person name="de Beer Z.W."/>
                <person name="De Vos L."/>
                <person name="Chen L."/>
                <person name="Duong T.A."/>
                <person name="Gao Y."/>
                <person name="Hammerbacher A."/>
                <person name="Kikkert J.R."/>
                <person name="Li Y."/>
                <person name="Li H."/>
                <person name="Li K."/>
                <person name="Li Q."/>
                <person name="Liu X."/>
                <person name="Ma X."/>
                <person name="Naidoo K."/>
                <person name="Pethybridge S.J."/>
                <person name="Sun J."/>
                <person name="Steenkamp E.T."/>
                <person name="van der Nest M.A."/>
                <person name="van Wyk S."/>
                <person name="Wingfield M.J."/>
                <person name="Xiong C."/>
                <person name="Yue Q."/>
                <person name="Zhang X."/>
            </authorList>
            <dbReference type="PubMed" id="30018880"/>
            <dbReference type="DOI" id="10.5598/imafungus.2018.09.01.13"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5 6">BP5796</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="PDLN01000003">
        <property type="protein sequence ID" value="RDW91616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A0A3D8SZ91"/>
    <dbReference type="OrthoDB" id="5818554at2759"/>
    <dbReference type="Proteomes" id="UP000256328">
        <property type="component" value="Unassembled WGS sequence"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12148">
        <property type="entry name" value="fungal_TF_MHR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00067">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.240.10">
        <property type="entry name" value="Zn(2)-C6 fungal-type DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052780">
        <property type="entry name" value="AAA_Catabolism_Regulators"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007219">
        <property type="entry name" value="XnlR_reg_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036864">
        <property type="entry name" value="Zn2-C6_fun-type_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001138">
        <property type="entry name" value="Zn2Cys6_DnaBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644">
        <property type="entry name" value="TRANSCRIPTIONAL ACTIVATOR ARO80-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31644:SF1">
        <property type="entry name" value="ZN(II)2CYS6 TRANSCRIPTION FACTOR (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04082">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00172">
        <property type="entry name" value="Zn_clus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00906">
        <property type="entry name" value="Fungal_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00066">
        <property type="entry name" value="GAL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57701">
        <property type="entry name" value="Zn2/Cys6 DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00463">
        <property type="entry name" value="ZN2_CY6_FUNGAL_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50048">
        <property type="entry name" value="ZN2_CY6_FUNGAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Zn(2)-C6 fungal-type" evidence="4">
        <location>
            <begin position="102"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="138"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="295"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="52"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="188"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="241"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="295"/>
            <end position="304"/>
    
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